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[{"$nulls":3},"Ferroptosis Compound Library  (96-well)-L6400"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 724 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L6400-01~09;    In 2 mM DMSO : Plate layout L6400-11"]
[{"$nulls":3},"In 10 mM Water: Plate layout L6400-10;      In 2 mM Water  : Plate layout L6400-12"]
[]
[]
[null,"Plate layout: L6400-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1007","S1102","S1247","S1398","S1568","S1748","S1848","S1994","S2077","S2269","Empty"]
[{"$nulls":3},"Roxadustat (FG-4592)","U0126-EtOH","Leflunomide (HWA486)","Stavudine (d4T)","PD318088","Nisoldipine","Curcumin","Lacidipine","Atorvastatin Calcium","Baicalin (NSC-661431)"]
[null,"b","Empty","S1028","S1104","S1282","S1431","S1576","S1759","S1849","S2011","S2111","S2270","Empty"]
[{"$nulls":3},"Lapatinib (GW-572016) Ditosylate","GDC-0879","Artemisinin","Sildenafil Citrate","Sulfasalazine (NSC 667219)","Pitavastatin (NK-104) calcium","Daidzein","Pramipexole 2HCl Monohydrate","Lapatinib (GW-572016)","Bergenin"]
[null,"c","Empty","S1036","S1137","S1290","S1443","S1630","S1773","S1897","S2046","S2131","S2271","Empty"]
[{"$nulls":3},"Mirdametinib (PD0325901)","Malotilate","Celastrol (NSC 70931)","Zileuton (A-64077)","Allopurinol","Oxytetracycline (Terramycin)","Potassium Iodide","Pioglitazone HCl","Roflumilast (B9302-107)","Berberine chloride (NSC 646666)"]
[null,"d","Empty","S1040","S1152","S1319","S1445","S1631","S1792","S1905","S2052","S2134","S2277","Empty"]
[{"$nulls":3},"Sorafenib (BAY 43-9006) tosylate","PLX-4720","Costunolide","Zonisamide","Allopurinol Sodium","Simvastatin (MK 733)","Amlodipine","Oxytetracycline Dihydrate","AZD8330","Caffeic Acid"]
[null,"e","Empty","S1052","S1172","S1344","S1460","S1655","S1813","S1907","S2060","S2250","S2280","Empty"]
[{"$nulls":3},"Elesclomol (STA-4783)","Serdemetan (JNJ-26854165)","Glimepiride","SP600125","Ezetimibe (SCH-58235)","Amlodipine Besylate","Metronidazole","Bromhexine HCl","(-)-Epigallocatechin Gallate","Chlorogenic Acid"]
[null,"f","Empty","S1061","S1177","S1354","S1467","S1677","S1825","S1909","S2061","S2265","S2281","Empty"]
[{"$nulls":3},"Nutlin-3","PD98059","Lansoprazole","Doxercalciferol","Chloramphenicol","Erdosteine","Fluvastatin (XU-62-320) Sodium","Lovastatin (MK-803)","Artesunate (WR-256283)","Chrysin"]
[null,"g","Empty","S1068","S1204","S1357","S1540","S1696","S1830","S1952","S2062","S2266","S2289","Empty"]
[{"$nulls":3},"Crizotinib (PF-02341066)","Melatonin (NSC 113928)","Lidocaine","Saxagliptin (BMS-477118)","Hydrocortisone (NSC 10483)","Oxfendazole","Methoxsalen","Tiopronin","Asiatic Acid","Daidzin"]
[null,"h","Empty","S1077","S1222","S1396","S1547","S1712","S1831","S1988","S2075","S2268","S2293","Empty"]
[{"$nulls":3},"SB202190 (FHPI)","Dexrazoxane HCl (ICRF-187)","Resveratrol (SRT501)","Febuxostat","Deferasirox (ICL-670)","Carvedilol","Propylthiouracil","Rosiglitazone (BRL-49653) HCl","Baicalein","DL-Carnitine HCl"]
[]
[]
[]
[null,"Plate layout: L6400-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2298","S2329","S2350","S2389","S2405","S2528","S2720","S2926","S3113","S3624","Empty"]
[{"$nulls":3},"Fisetin","Naringin","Rutin","Naringin Dihydrochalcone","Sophocarpine","Ciclopirox","ZM 336372","TDZD-8","Pyridoxine HCl","Quinolinic acid"]
[null,"b","Empty","S2302","S2331","S2354","S2391","S2411","S2532","S2721","S2929","S3114","S3626","Empty"]
[{"$nulls":3},"Glycyrrhizin (NSC 167409)","Neohesperidin Dihydrochalcone (Nhdc)","Sclareol","Quercetin (NSC 9221)","Geniposide","L-Ascorbyl 6-palmitate","Nilvadipine","Pifithrin-α (PFTα) HBr","Vitamin C","Sesamol"]
[null,"c","Empty","S2308","S2332","S2357","S2394","S2413","S2556","S2746","S2930","S3600","S3629","Empty"]
[{"$nulls":3},"Hesperetin","Neohesperidin","Silibinin (NSC 651520)","Naringenin","Geniposidic acid","Rosiglitazone (BRL 49653)","AZ 628","Pifithrin-μ","Schisandrin B (Sch B)","Syringic acid"]
[null,"d","Empty","S2309","S2333","S2358","S2396","S2415","S2586","S2747","S3019","S3609","S3630","Empty"]
[{"$nulls":3},"Hesperidin","Nobiletin (NSC 76751)","Silymarin","Salidroside","Astragaloside A","Dimethyl Fumarate","AMG-458","Ciclopirox ethanolamine","Berbamine dihydrochloride","Methyl Vanillate"]
[null,"e","Empty","S2310","S2341","S2363","S2397","S2450","S2590","S2781","S3031","S3612","S3639","Empty"]
[{"$nulls":3},"Honokiol (NSC 293100)","(-)-Parthenolide","Tangeretin","Palmatine chloride","Equol","Pioglitazone (AD-4833)","RITA (NSC 652287)","Linagliptin (BI-1356)","Rosmarinic acid","Tacrine hydrochloride hydrate"]
[null,"f","Empty","S2320","S2342","S2365","S2399","S2460","S2605","S2797","S3033","S3613","S3652","Empty"]
[{"$nulls":3},"Luteolin","Phloretin (RJC 02792)","Tanshinone IIA","Dihydromyricetin","Pramipexole","Idebenone","Lonafarnib (SCH66336)","Vildagliptin (LAF-237)","Scoparone","3-Nitropropionic acid"]
[null,"g","Empty","S2325","S2347","S2369","S2400","S2505","S2617","S2843","S3036","S3616","S3665","Empty"]
[{"$nulls":3},"Morin Hydrate","Quercetin Dihydrate","Troxerutin","Rheic Acid","Rosiglitazone (BRL-49653) maleate","TAK-733","BI-D1870","Pravastatin sodium","Asiaticoside","Trolox"]
[null,"h","Empty","S2326","S2348","S2375","S2401","S2526","S2664","S2910","S3077","S3617","S3671","Empty"]
[{"$nulls":3},"Myricetin","Rotenone (Barbasco)","Aloin","Sodium Danshensu","Alizarin","Clinofibrate","Tempol","Tazobactam","(20S)-Protopanaxatriol","Quinestrol"]
[]
[]
[]
[null,"Plate layout: L6400-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3675","S3773","S3788","S3813","S3828","S3840","S3857","S3884","S3924","S3952","Empty"]
[{"$nulls":3},"Umbelliferone","Tyrosol","Carvacrol","Bakuchiol","Orcinol glucoside","Baohuoside I","4-Hydroxybenzyl alcohol","Jatrorrhizine","Ginsenoside Rb1","3,4-Dihydroxybenzaldehyde"]
[null,"b","Empty","S3679","S3775","S3790","S3815","S3833","S3842","S3859","S3885","S3925","S3956","Empty"]
[{"$nulls":3},"Flavanone","Ligustrazine hydrochloride","Methyl gallate","Mogroside V","Amentoflavone","Isoquercitrin","Vanillyl Alcohol","Pyrogallol","(-)-Epicatechin gallate","Tetramethylpyrazine"]
[null,"c","Empty","S3681","S3777","S3799","S3816","S3834","S3843","S3860","S3888","S3926","S3957","Empty"]
[{"$nulls":3},"Vitamin E Acetate","Gentiopicroside","Gentisic acid","Dehydroevodiamine","Astaxanthin","Madecassoside","Allicin","3,4',5-Trimethoxy-trans-stilbene","Forsythin","Gamma-Oryzanol"]
[null,"d","Empty","S3694","S3780","S3802","S3818","S3835","S3846","S3862","S3899","S3930","S3967","Empty"]
[{"$nulls":3},"Glucosamine hydrochloride","Secoisolariciresinol diglucoside","Trigonelline Hydrochloride","Tectoridin","Loganin","Eupatilin","Gallic acid trimethyl ether","Hederagenin","Liquiritin","Flavone"]
[null,"e","Empty","S3764","S3783","S3804","S3820","S3836","S3848","S3869","S3905","S3932","S3968","Empty"]
[{"$nulls":3},"Isoferulic Acid","Echinacoside","Alpha-Mangostin","Dehydroevodiamine hydrochloride","6-Gingerol","Hydroxytyrosol Acetate","Methyl protocatechuate","Iso-Steviol","Astilbin","Histamine"]
[null,"f","Empty","S3765","S3784","S3808","S3822","S3837","S3849","S3870","S3906","S3934","S3969","Empty"]
[{"$nulls":3},"Picroside II","Obacunone (AI3-37934)","Mangiferin","Schisandrin A","Echinocystic acid","D-Galactose","D-Pinitol","Astragalus polyphenols","Acetyl Resveratrol","Veratric acid"]
[null,"g","Empty","S3769","S3785","S3810","S3824","S3838","S3850","S3881","S3909","S3937","S3974","Empty"]
[{"$nulls":3},"Palmatine","Notoginsenoside R1","Scutellarin","Quercitrin","Carnosic acid","Glucosamine sulfate","Scopoletin","Catalpol","Pterostilbene","(+)-Catechin hydrate"]
[null,"h","Empty","S3771","S3786","S3811","S3826","S3839","S3855","S3883","S3917","S3941","S3975","Empty"]
[{"$nulls":3},"Stachydrine","Glabridin","Ginsenoside Re","Hydroxytyrosol","1-Deoxynojirimycin","Ethyl ferulate","Protopine","Tetrahydrocurcumin","Pinocembrin","Protocatechuic acid"]
[]
[]
[]
[null,"Plate layout: L6400-04"]
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["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1007","Roxadustat (FG-4592)","a2","L6400-01","in 10mM DMSO","Ferroptosis,HIF","Angiogenesis","Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.",352.34,"808118-40-3",{"v":70,"d":"70.00"},198.67,"<1","N/A","http://selleckchem.com/products/fg-4592.html","C19H16N2O5","free base","ASP1517","CC1=NC(=C(O)C2=C1C=C(OC3=CC=CC=C3)C=C2)C(=O)NCC(O)=O",2.306,4,2,5]
["S1028","Lapatinib (GW-572016) Ditosylate","b2","L6400-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.",925.46,"388082-77-7",{"v":100,"d":"100.00"},108.05,"<1","N/A","http://selleckchem.com/products/Lapatinib-Ditosylate.html","C29H26ClFN4O4S.2C7H8O3S","Ditosylat","GW-572016","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(=C7)F)C(=C6)Cl)C5=C4",9.339,6,2,13]
["S1036","Mirdametinib (PD0325901)","c2","L6400-01","in 10mM DMSO","MEK","MAPK","Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.",482.19,"391210-10-9",{"v":96,"d":"96.00"},199.09,"<1","N/A","http://selleckchem.com/products/PD-0325901.html","C16H14F3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C=C1)F",2.578,2,4,7]
["S1040","Sorafenib (BAY 43-9006) tosylate","d2","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate)  is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",637.03,"475207-59-1",{"v":127,"d":"127.00"},199.36,0.01,0.02,"http://selleckchem.com/products/Sorafenib-Tosylate.html","C21H16ClF3N4O3.C7H8O3S","Tosylate","BAY 43-9006 tosylate,NSC-724772 tosylate","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O",5.824,4,3,7]
["S1052","Elesclomol (STA-4783)","e2","L6400-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.",{"v":400.5,"d":"400.50"},"488832-69-5",{"v":80,"d":"80.00"},199.75,"<1","N/A","http://selleckchem.com/products/Elesclomol.html","C19H20N4O2S2","free base","N/A","CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2",2.885,2,2,8]
["S1061","Nutlin-3","f2","L6400-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1068","Crizotinib (PF-02341066)","g2","L6400-01","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",450.34,"877399-52-5",{"v":9,"d":"9.00"},19.98,"<1","N/A","http://selleckchem.com/products/PF-2341066.html","C21H22Cl2FN5O","free base","PF-02341066","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S1077","SB202190 (FHPI)","h2","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,p38 MAPK","MAPK","SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.",331.34,"152121-30-7",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/SB-202190.html","C20H14N3OF","free base","N/A","OC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",4.211,2,2,3]
["S1102","U0126-EtOH","a3","L6400-01","in 10mM DMSO","Antiviral,Autophagy,MEK,Mitophagy","MAPK","U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.",426.56,"1173097-76-1",{"v":85,"d":"85.00"},199.27,"<1","N/A","http://selleckchem.com/products/U0126.html","C18H16N6S2.C2H6O","Ethanolate","N/A","CCO.N\\C(SC1=CC=CC=C1N)=C(C#N)\\C(C#N)=C(N)/SC2=CC=CC=C2N",2.169,0,5,5]
["S1104","GDC-0879","b3","L6400-01","in 10mM DMSO","Raf","MAPK","GDC-0879 (AR-00341677) is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well; no inhibition known to other protein kinases.",334.37,"905281-76-7",{"v":66,"d":"66.00"},197.39,"<1","N/A","http://selleckchem.com/products/GDC-0879.html","C19H18N4O2","free base","AR-00341677","OCC[N]1C=C(C2=CC=C\\3C(=C2)CCC3=N\\O)C(=N1)C4=CC=NC=C4",2.387,3,1,4]
["S1137","Malotilate","c3","L6400-01","in 10mM DMSO","Lipoxygenase","Metabolism","Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.",288.38,"59937-28-9",{"v":58,"d":"58.00"},201.12,"<1","N/A","http://selleckchem.com/products/Malotilate.html","C12H16O4S2","free base","NKK105","CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1",2.363,4,0,6]
["S1152","PLX-4720","d3","L6400-01","in 10mM DMSO","Raf","MAPK","PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.",413.83,"918505-84-7",{"v":83,"d":"83.00"},200.57,"<1","N/A","http://selleckchem.com/products/PLX-4720.html","C17H14ClF2N3O3S","free base","N/A","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(Cl)C=C23",3.435,4,2,6]
["S1172","Serdemetan (JNJ-26854165)","e3","L6400-01","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1177","PD98059","f3","L6400-01","in 10mM DMSO","AhR,MEK","MAPK","PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.",267.28,"167869-21-8",{"v":14,"d":"14.00"},52.38,"<1","N/A","http://selleckchem.com/products/PD-98059.html","C16H13NO3","free base","N/A","COC1=C(N)C(=CC=C1)C2=CC(=O)C3=CC=CC=C3O2",2.373,3,1,2]
["S1204","Melatonin (NSC 113928)","g3","L6400-01","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1","N/A","http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1222","Dexrazoxane HCl (ICRF-187)","h3","L6400-01","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Dexrazoxane HCl (ADR-529,Totect, ICRF-187, Zinecard, Cardioxane) is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent; also an inhibitor of topoisomerase II",304.73,"149003-01-0",{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},"http://selleckchem.com/products/Dexrazoxane-Hydrochloride.html","C11H16N4O4.HCl","Hydrochloride","ADR-529,Totect, ICRF-187, Zinecard, Cardioxane","Cl.CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-1.722,4,2,3]
["S1247","Leflunomide (HWA486)","a4","L6400-01","in 10mM DMSO","AhR,Dehydrogenase","Metabolism","Leflunomide (HWA486, RS-34821, SU101, Arava) is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of Leflunomide is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). Leflunomide is also an agonist of the AhR.",270.21,"75706-12-6",{"v":54,"d":"54.00"},199.84,"<1","N/A","http://selleckchem.com/products/Leflunomide.html","C12H9F3N2O2","free base","HWA486, RS-34821, SU101, Arava","CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F",2.156,3,1,3]
["S1282","Artemisinin","b4","L6400-01","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.",282.33,"63968-64-9",{"v":57,"d":"57.00"},201.89,"<1","N/A","http://selleckchem.com/products/Artemisinin.html","C15H22O5","free base","Qinghaosu,Artemisinine,Coartem,NSC 369397","CC1CCC2C(C)C(=O)OC3OC4(C)CCC1C23OO4",1.998,5,0,0]
["S1290","Celastrol (NSC 70931)","c4","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1319","Costunolide","d4","L6400-01","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.",232.32,"553-21-9",{"v":47,"d":"47.00"},202.31,"<1","N/A","http://selleckchem.com/products/Costunolide.html","C15H20O2","free base","NSC 106404","CC/1=C\\CC\\C(=C\\C2OC(=O)C(=C)C2CC1)C",4.022,2,0,0]
["S1344","Glimepiride","e4","L6400-01","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glimepiride(HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.",490.62,"93479-97-1",{"v":11,"d":"11.00"},22.42,"<1","N/A","http://selleckchem.com/products/Glimepiride.html","C24H34N4O5S","free base","HOE-490","CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCC(C)CC3)C1=O",3.781,5,3,7]
["S1354","Lansoprazole","f4","L6400-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.",369.36,"103577-45-3",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/Lansoprazole.html","C16H14F3N3O2S","free base","A-65006, AG-1749","CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2",3.442,4,1,6]
["S1357","Lidocaine","g4","L6400-01","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.",234.34,"137-58-6",{"v":47,"d":"47.00"},200.56,{"v":9,"d":"9.00"},38.41,"http://selleckchem.com/products/Lidocaine.html","C14H22N2O","Free Base","Alphacaine","CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",2.626,1,1,5]
["S1396","Resveratrol (SRT501)","h4","L6400-01","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1","N/A","http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1398","Stavudine (d4T)","a5","L6400-01","in 10mM DMSO","Reverse Transcriptase","Microbiology","Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.",224.21,"3056-17-5",{"v":45,"d":"45.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/Stavudine.html","C10H12N2O4","free base","BMY-27857, Sanilvudine, NSC 163661,d4T","CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O",-0.515,3,2,2]
["S1431","Sildenafil Citrate","b5","L6400-01","in 10mM DMSO","PDE","Metabolism","Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.",{"v":666.7,"d":"666.70"},"171599-83-0",{"v":20,"d":"20.00"},{"v":30,"d":"30.00"},"<1","N/A","http://selleckchem.com/products/Sildenafil-citrate.html","C22H30N6O4S.C6H8O7","Citrate","N/A","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.OC(=O)CC(O)(CC(O)=O)C(O)=O",-2.107,9,1,12]
["S1443","Zileuton (A-64077)","c5","L6400-01","in 10mM DMSO","Apoptosis related,Ferroptosis,Lipoxygenase","Metabolism","Zileuton (A-64077, Abbott 64077, ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. Zileuton induces apoptosis while inhibits ferroptosis.",236.29,"111406-87-2",{"v":47,"d":"47.00"},198.91,"<1","N/A","http://selleckchem.com/products/Zileuton.html","C11H12N2O2S","free base","A-64077, Abbott 64077, ZYFLO","CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1",2.184,1,1,2]
["S1445","Zonisamide","d5","L6400-01","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.",212.23,"68291-97-4",{"v":42,"d":"42.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/Zonisamide.html","C8H8N2O3S","free base","Zonegran,CI-912,AD 810","N[S](=O)(=O)CC1=NOC2=CC=CC=C12",0.411,4,1,2]
["S1460","SP600125","e5","L6400-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,FLT3,JNK,Serine/threonin kinase,Trk receptor","MAPK","SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.",220.23,"129-56-6",{"v":44,"d":"44.00"},199.79,"<1","N/A","http://selleckchem.com/products/SP600125.html","C14H8N2O","free base","Nsc75890","O=C1C2=C(C=CC=C2)C3=N[NH]C4=CC=CC1=C34",2.994,2,1,0]
["S1467","Doxercalciferol","f5","L6400-01","in 10mM DMSO","Vitamin","Metabolism","Doxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.",412.65,"54573-75-0",{"v":83,"d":"83.00"},201.14,"<1","N/A","http://selleckchem.com/products/Doxercalciferol(Hectorol).html","C28H44O2","free base","1α-hydroxyvitamin D2","CC(C)C(C)/C=C/C(C)C1CCC2C(/CCCC12C)=C/C=C/3CC(O)CC(O)C3=C",6.337,0,2,5]
["S1540","Saxagliptin (BMS-477118)","g5","L6400-01","in 10mM DMSO","DPP","Proteases","Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",315.41,"361442-04-8",{"v":63,"d":"63.00"},199.74,{"v":63,"d":"63.00"},199.74,"http://selleckchem.com/products/Saxagliptin(Onglyza).html","C18H25N3O2","Free Base","Onglyza,BMS-477118","NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.275,1,1,2]
["S1547","Febuxostat","h5","L6400-01","in 10mM DMSO","ROS","Immunology & Inflammation","Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.",316.37,"144060-53-7",{"v":63,"d":"63.00"},199.13,"<1","N/A","http://selleckchem.com/products/Febuxostat(Uloric).html","C16H16N2O3S","free base","TMX 67, TEI-6720","CC(C)COC1=C(C=C(C=C1)C2=NC(=C(S2)C(O)=O)C)C#N",3.468,3,0,5]
["S1568","PD318088","a6","L6400-01","in 10mM DMSO","MEK","MAPK","PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.",561.09,"391210-00-7",{"v":112,"d":"112.00"},199.61,"<1","N/A","http://selleckchem.com/products/PD318088.html","C16H13BrF3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C(=C1)Br)F",3.327,2,4,7]
["S1576","Sulfasalazine (NSC 667219)","b6","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1","N/A","http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1630","Allopurinol","c6","L6400-01","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.",136.11,"315-30-0",{"v":27,"d":"27.00"},198.37,{"v":4,"d":"4.00"},29.39,"http://selleckchem.com/products/Allopurinol(Zyloprim).html","C5H4N4O","Free Base","N/A","O=C1N=CN=C2NNC=C12",-2.125,3,2,0]
["S1631","Allopurinol Sodium","d6","L6400-01","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol Sodium  is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.",{"v":159.1,"d":"159.10"},"17795-21-0",{"v":32,"d":"32.00"},201.13,{"v":32,"d":"32.00"},201.13,"http://selleckchem.com/products/Allopurinol-Sodium(Aloprim).html","C5H4N4NaO","Sodium Salt","N/A","[Na+].O=C1NC=NC2=C1C=N[NH]2",-0.681,3,2,0]
["S1655","Ezetimibe (SCH-58235)","e6","L6400-01","in 10mM DMSO","LDL","Metabolism","Ezetimibe (SCH-58235) is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.",{"v":409.4,"d":"409.40"},"163222-33-1",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/Ezetimibe(Zetia).html","C24H21F2NO3","free base","SCH-58235","OC(CCC1C(N(C1=O)C2=CC=C(F)C=C2)C3=CC=C(O)C=C3)C4=CC=C(F)C=C4",4.633,1,2,6]
["S1677","Chloramphenicol","f6","L6400-01","in 10mM DMSO","Antibiotics for Plant Cell Culture,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.",323.13,"56-75-7",{"v":65,"d":"65.00"},201.16,"<1","N/A","http://selleckchem.com/products/Chloramphenicol(Chloromycetin).html","C11H12Cl2N2O5","free base","Chloromycetin","OCC(NC(=O)C(Cl)Cl)C(O)C1=CC=C(C=C1)[N+]([O-])=O",1.025,1,3,6]
["S1696","Hydrocortisone (NSC 10483)","g6","L6400-01","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.",362.46,"50-23-7",{"v":73,"d":"73.00"},{"v":201.4,"d":"201.40"},"<1","N/A","http://selleckchem.com/products/Hydrocortisone.html","C21H30O5","free base","Cortisol","CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)CO)C4(C)CC(O)C23",1.283,2,2,2]
["S1712","Deferasirox (ICL-670)","h6","L6400-01","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17)","Proteases","Deferasirox (ICL-670, CGP-72670) is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.",373.36,"201530-41-8",{"v":74,"d":"74.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Deferasirox(Exjade).html","C21H15N3O4","free base","CGP-72670, ICL-670","OC(=O)C1=CC=C(C=C1)[N]2N=C(N=C2C3=CC=CC=C3O)C4=CC=CC=C4O",4.063,3,2,4]
["S1748","Nisoldipine","a7","L6400-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.",388.41,"63675-72-9",{"v":77,"d":"77.00"},198.24,"<1","N/A","http://selleckchem.com/products/Nisoldipine(Sular).html","C20H24N2O6","free base","BAY K 5552","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC=C2[N+]([O-])=O)C(=O)OCC(C)C)C",2.958,4,1,8]
["S1759","Pitavastatin (NK-104) calcium","b7","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1773","Oxytetracycline (Terramycin)","c7","L6400-01","in 10mM DMSO","Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Others","Oxytetracycline(Terramycin) is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.",460.43,"79-57-2",{"v":92,"d":"92.00"},199.81,"<1","N/A","http://selleckchem.com/products/Oxytetracycline(Terramycin).html","C22H24N2O9","free base","Terramycin","CN(C)C1C2C(O)C3C(=C(O)C4=C(C=CC=C4O)C3(C)O)C(=O)C2(O)C(=O)C(=C1O)C(N)=O",-1.904,3,5,2]
["S1792","Simvastatin (MK 733)","d7","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1813","Amlodipine Besylate","e7","L6400-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",567.05,"111470-99-6",{"v":113,"d":"113.00"},199.28,"<1","N/A","http://selleckchem.com/products/Amlodipine-besylate(Norvasc).html","C20H25ClN2O5.C6H6O3S","Besylate","N/A","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C.O[S](=O)(=O)C3=CC=CC=C3",2.739,5,2,11]
["S1825","Erdosteine","f7","L6400-01","in 10mM DMSO","NF-κB","NF-κB","Erdosteine (KW-9144,RV 144) is a mucolytic which is used in treatment of excessive viscous mucus. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation.",249.31,"84611-23-4",{"v":50,"d":"50.00"},200.55,"<1","N/A","http://selleckchem.com/products/erdosteine.html","C8H11NO4S2","free base","KW-9144,RV 144","OC(=O)CSCC(=O)NC1CCSC1=O",-0.382,3,1,5]
["S1830","Oxfendazole","g7","L6400-01","in 10mM DMSO","Parasite","Microbiology","Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.",315.35,"53716-50-0",{"v":10,"d":"10.00"},31.71,"<1","N/A","http://selleckchem.com/products/oxfendazole.html","C15H13N3O3S","free base","RS-8858,Fenbendazole sulfoxide","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)[S](=O)C3=CC=CC=C3",2.657,4,2,4]
["S1831","Carvedilol","h7","L6400-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.",406.47,"72956-09-3",{"v":81,"d":"81.00"},199.28,"<1","N/A","http://selleckchem.com/products/carvedilol.html","C24H26N2O4","free base","BM-14190, SKF 105517","COC1=CC=CC=C1OCCNCC(O)COC2=C3C(=CC=C2)[NH]C4=C3C=CC=C4",4.014,3,3,10]
["S1848","Curcumin","a8","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S1849","Daidzein","b8","L6400-01","in 10mM DMSO","PPAR","Metabolism","Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.",254.24,"486-66-8",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Daidzein.html","C15H10O4","free base","N/A","OC1=CC=C(C=C1)C2=COC3=CC(=CC=C3C2=O)O",2.382,2,2,1]
["S1897","Potassium Iodide","c8","L6400-01","in 10mM DMSO","Others","Others","Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.",{"v":166,"d":"166.00"},"7681-11-0",{"v":33,"d":"33.00"},{"v":198.8,"d":"198.80"},{"v":33,"d":"33.00"},{"v":198.8,"d":"198.80"},"http://selleckchem.com/products/Potassium-iodide.html","K+I-","Inorganic salt","N/A","[K+].[I-]",-3.113,0,0,0]
["S1905","Amlodipine","d8","L6400-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",408.88,"88150-42-9",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Amlodipine(Norvasc).html","C20H25ClN2O5","free base","UK-48340","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C",1.576,5,2,10]
["S1907","Metronidazole","e8","L6400-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.",171.15,"443-48-1",{"v":34,"d":"34.00"},198.66,"<1","N/A","http://selleckchem.com/products/Metronidazole(Flagyl).html","C6H9N3O3","free base","N/A","CC1=NC=C([N]1CCO)[N+]([O-])=O",-0.337,1,1,3]
["S1909","Fluvastatin (XU-62-320) Sodium","f8","L6400-01","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Fluvastatin Sodium (Vastin,XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.",433.45,"93957-55-2",{"v":87,"d":"87.00"},200.72,{"v":1,"d":"1.00"},2.31,"http://selleckchem.com/products/Fluvastatin-Sodium(Lescol).html","C24H25FNNaO4","Sodium","Vastin,XU-62-320","[Na+].CC(C)[N]1C2=C(C=CC=C2)C(=C1\\C=C\\C(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3",{"v":2.77,"d":"2.770"},0,2,8]
["S1952","Methoxsalen","g8","L6400-01","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.",216.19,"298-81-7",{"v":43,"d":"43.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Methoxsalen(Oxsoralen).html","C12H8O4","free base","Xanthotoxin, NCI-C55903","COC1=C2OC=CC2=CC3=C1OC(=O)C=C3",2.187,4,0,1]
["S1988","Propylthiouracil","h8","L6400-01","in 10mM DMSO","Peroxidases","Metabolism","Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.",170.23,"51-52-5",{"v":34,"d":"34.00"},199.73,"<1","N/A","http://selleckchem.com/products/Propylthiouracil.html","C7H10N2OS","free base","NSC 6498, NSC 70461","CCCC1=CC(=O)NC(=S)N1",1.575,1,2,2]
["S1994","Lacidipine","a9","L6400-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.",455.54,"103890-78-4",{"v":91,"d":"91.00"},199.76,"<1","N/A","http://selleckchem.com/products/lacidipine-lacipil-motens.html","C26H33NO6","free base","GX-1048, GR-43659X, SN-305","CCOC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)\\C=C\\C(=O)OC(C)(C)C)C(=O)OCC)C",3.824,6,1,11]
["S2011","Pramipexole 2HCl Monohydrate","b9","L6400-01","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.",302.26,"191217-81-9",{"v":41,"d":"41.00"},135.64,{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/Pramipexole-dihydrochloride-monohydrate.html","C10H17N3S.2HCl.H2O","Dihydrochloride monohydrate","N/A","O.Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",{"v":1.94,"d":"1.940"},1,2,3]
["S2046","Pioglitazone HCl","c9","L6400-01","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17),PPAR","Metabolism","Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.",{"v":392.9,"d":"392.90"},"112529-15-4",{"v":79,"d":"79.00"},201.07,"<1","N/A","http://selleckchem.com/products/pioglitazone-hydrochloride-actos.html","C19H20N2O3S.HCl","Hydrochloride","AD-4833, U-72107E","Cl.CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",4.289,4,1,7]
["S2052","Oxytetracycline Dihydrate","d9","L6400-01","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.",496.46,"6153-64-6",{"v":5,"d":"5.00"},10.07,"<1","N/A","http://selleckchem.com/products/oxytetracycline-dihydrate.html","C22H24N2O9.2H2O","Dihydrate","N/A","O.O.CN(C)C1C2C(O)C3C(=C(O)C2(O)C(=O)C(=C1O)C(N)=O)C(=O)C4=C(O)C=CC=C4C3(C)O",-2.309,3,5,2]
["S2060","Bromhexine HCl","e9","L6400-01","in 10mM DMSO","Others","Others","Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.",412.59,"611-75-6",{"v":6,"d":"6.00"},14.54,"<1","N/A","http://selleckchem.com/products/bromhexine-hydrochloride.html","C14H20Br2N2.HCl","HCl","N/A","Cl.CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2",4.894,0,1,3]
["S2061","Lovastatin (MK-803)","f9","L6400-01","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Lovastatin (MK-803, Mevinolin,Mevacor) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.",404.54,"75330-75-5",{"v":8,"d":"8.00"},19.78,"<1","N/A","http://selleckchem.com/products/lovastatin-mevacor.html","C24H36O5","free base","Mevinolin,Mevacor","CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.218,4,1,7]
["S2062","Tiopronin","g9","L6400-01","in 10mM DMSO","ROS","Immunology & Inflammation","Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.",163.19,"1953-02-2",{"v":32,"d":"32.00"},196.09,{"v":32,"d":"32.00"},196.09,"http://selleckchem.com/products/tiopronin-thiola.html","C5H9NO3S","free base","N/A","CC(S)C(=O)NCC(O)=O",-0.362,2,1,3]
["S2075","Rosiglitazone (BRL-49653) HCl","h9","L6400-01","in 10mM DMSO","PPAR","Metabolism","Rosiglitazone HCl (BRL-49653) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.",393.89,"302543-62-0",{"v":79,"d":"79.00"},200.56,"<1","N/A","http://selleckchem.com/products/rosiglitazone-hydrochloride.html","C18H19N3O3S.HCl","HCl","BRL-49653 HCl","Cl.CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",{"v":3.65,"d":"3.650"},4,1,7]
["S2077","Atorvastatin Calcium","a10","L6400-01","in 10mM DMSO","Apoptosis related,Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.",1155.34,"134523-03-8",{"v":100,"d":"100.00"},86.55,"<1","N/A","http://selleckchem.com/products/atorvastatin-calcium-lipitor.html","2(C33H34FN2O5).Ca","Calcium","N/A","[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8",8.163,2,6,24]
["S2111","Lapatinib (GW-572016)","b10","L6400-01","in 10mM DMSO","Autophagy,EGFR,Ferroptosis,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.",581.06,"231277-92-2",{"v":100,"d":"100.00"},{"v":172.1,"d":"172.10"},"<1","N/A","http://selleckchem.com/products/lapatinib.html","C29H26ClFN4O4S","free base","GSK572016, GW2016","C[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(=C5)F)C(=C4)Cl)C3=C2",6.041,6,2,11]
["S2131","Roflumilast (B9302-107)","c10","L6400-01","in 10mM DMSO","PDE","Metabolism","Roflumilast (APTA 2217, B9302-107, BY 217, BYK 20869) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.",403.21,"162401-32-3",{"v":81,"d":"81.00"},200.89,"<1","N/A","http://selleckchem.com/products/Roflumilast(Daxas).html","C17H14Cl2F2N2O3","free base","APTA 2217, B9302-107, BY 217, BYK 20869","FC(F)OC1=CC=C(C=C1OCC2CC2)C(=O)NC3=C(Cl)C=NC=C3Cl",4.402,4,1,7]
["S2134","AZD8330","d10","L6400-01","in 10mM DMSO","MEK","MAPK","AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.",461.23,"869357-68-6",{"v":92,"d":"92.00"},199.47,"<1","N/A","http://selleckchem.com/products/AZD8330(ARRY-424704).html","C16H17FIN3O4","free base","ARRY704","CN1C(=O)C(=CC(=C1NC2=C(F)C=C(I)C=C2)C(=O)NOCCO)C",1.653,3,3,6]
["S2250","(-)-Epigallocatechin Gallate","e10","L6400-01","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2265","Artesunate (WR-256283)","f10","L6400-01","in 10mM DMSO","ADC Cytotoxin,STAT","JAK/STAT","Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.",384.42,"88495-63-0",{"v":77,"d":"77.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/Artesunate.html","C19H28O8","free base","WR-256283","CC1CCC2C(C)C(OC3OC4(C)CCC1C23OO4)OC(=O)CCC(O)=O",1.845,7,0,5]
["S2266","Asiatic Acid","g10","L6400-01","in 10mM DMSO","p38 MAPK","MAPK","Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.",{"v":488.7,"d":"488.70"},"464-92-6",{"v":97,"d":"97.00"},198.49,"<1","N/A","http://selleckchem.com/products/Asiatic-acid.html","C30H48O5","free base","Dammarolic acid, Asiantic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(O)=O",4.435,1,3,2]
["S2268","Baicalein","h10","L6400-01","in 10mM DMSO","P450 (e.g. CYP17),PREP","Metabolism","Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.",270.24,"491-67-8",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Baicalein.html","C15H10O5","free base","N/A","OC1=C(O)C(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)O",{"v":2.41,"d":"2.410"},2,3,1]
["S2269","Baicalin (NSC-661431)","a11","L6400-01","in 10mM DMSO","GABA Receptor,PREP","Neuronal Signaling","Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.",446.36,"21967-41-9",{"v":89,"d":"89.00"},199.39,"<1","N/A","http://selleckchem.com/products/Baicalin.html","C21H18O11","free base","N/A","OC1C(O)C(OC(C1O)C(O)=O)OC2=C(O)C(=C3C(=O)C=C(OC3=C2)C4=CC=CC=C4)O",0.608,5,5,4]
["S2270","Bergenin","b11","L6400-01","in 10mM DMSO","Others","Others","Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.",328.27,"477-90-7",{"v":66,"d":"66.00"},201.05,"<1","N/A","http://selleckchem.com/products/Bergenin-(Cuscutin).html","C14H16O9","free base","Cuscutin","COC1=C(O)C2=C(C=C1O)C(=O)OC3C(O)C(O)C(CO)OC23",-0.849,4,5,2]
["S2271","Berberine chloride (NSC 646666)","c11","L6400-01","in 10mM DMSO","Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase","Microbiology","Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.",371.81,"633-65-8",{"v":40,"d":"40.00"},107.58,"<1","N/A","http://selleckchem.com/products/Berberine-Hydrochloride.html","C20H18NO4.Cl","chloride","Natural Yellow 18 chloride","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4",1.289,4,0,2]
["S2277","Caffeic Acid","d11","L6400-01","in 10mM DMSO","Lipoxygenase,TRP Channel","Transmembrane Transporters","Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).",180.16,"331-39-5",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/Caffeic-acid.html","C9H8O4","free base","N/A","OC(=O)/C=C/C1=CC=C(O)C(=C1)O",1.443,1,2,2]
["S2280","Chlorogenic Acid","e11","L6400-01","in 10mM DMSO","Others","Others","Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.",354.31,"327-97-9",{"v":71,"d":"71.00"},200.39,{"v":18,"d":"18.00"},{"v":50.8,"d":"50.80"},"http://selleckchem.com/products/Chlorogenic-acid.html","C16H18O9","free base","NSC 407296, Heriguard","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S2281","Chrysin","f11","L6400-01","in 10mM DMSO","Others","Others","Chrysin (NSC 407436) is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).",254.24,"480-40-0",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Chrysin.html","C15H10O4","free base","NSC 407436","OC1=CC2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=CC=C3",2.652,2,2,1]
["S2289","Daidzin","g11","L6400-01","in 10mM DMSO","Dehydrogenase","Metabolism","Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside), a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).",416.38,"552-66-9",{"v":83,"d":"83.00"},199.34,"<1","N/A","http://selleckchem.com/products/Daidzin.html","C21H20O9","Free Base","Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside","OCC1OC(OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",0.452,4,5,4]
["S2293","DL-Carnitine HCl","h11","L6400-01","in 10mM DMSO","Others","Others","DL-Carnitine HCl is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.",197.66,"461-05-2",{"v":40,"d":"40.00"},202.37,{"v":40,"d":"40.00"},202.37,"http://selleckchem.com/products/DL-Carnitine-hydrochloride.html","C7H15NO3.HCl","Hydrochloride","N/A","[Cl-].C[N+](C)(C)CC(O)CC(O)=O",{"v":-4.49,"d":"-4.490"},1,1,4]
["S2298","Fisetin","a2","L6400-02","in 10mM DMSO","Sirtuin","Epigenetics","Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.",286.24,"528-48-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","http://selleckchem.com/products/Fisetin(Fustel).html","C15H10O6","free base","N/A","OC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC(=C(O)C=C3)O)O",1.872,2,4,1]
["S2302","Glycyrrhizin (NSC 167409)","b2","L6400-02","in 10mM DMSO","Dehydrogenase,High-mobility Group,MAO","Metabolism","Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).",822.93,"1405-86-3",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Glycyrrhizic-acid.html","C42H62O16","free base","N/A","CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",2.417,8,5,7]
["S2308","Hesperetin","c2","L6400-02","in 10mM DMSO","Histamine Receptor,TGF-beta/Smad","TGF-beta/Smad","Hesperetin is a bioflavonoid and, to be more specific, a flavanone.",302.27,"520-33-2",{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/Hesperetin.html","C16H14O6","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.357,3,3,2]
["S2309","Hesperidin","d2","L6400-02","in 10mM DMSO","Others","Others","Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits.",610.56,"520-26-3",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/Hesperidin.html","C28H34O15","free base","Cirantin","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",-0.431,7,8,7]
["S2310","Honokiol (NSC 293100)","e2","L6400-02","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2320","Luteolin","f2","L6400-02","in 10mM DMSO","ADC Cytotoxin,PDE","Metabolism","Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.",286.24,"491-70-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/luteolin.html","C15H10O6","free base","Luteoline, Luteolol, Digitoflavone","OC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=C(O)C(=C3)O)O",2.168,2,4,1]
["S2325","Morin Hydrate","g2","L6400-02","in 10mM DMSO","Others","Others","Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).",320.25,"6202-27-3",{"v":64,"d":"64.00"},199.84,"<1","N/A","https://www.selleckchem.com/products/Morin-hydrate.html","C15H10O7.H2O","Hydrate","Aurantica","O.OC1=CC=C(C(=C1)O)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.423,2,5,1]
["S2326","Myricetin","h2","L6400-02","in 10mM DMSO","MEK","MAPK","Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.",318.24,"529-44-2",{"v":63,"d":"63.00"},197.96,"<1","N/A","http://selleckchem.com/products/Myricetin(Cannabiscetin).html","C15H10O8","free base","Cannabiscetin","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O)O",1.388,2,6,1]
["S2329","Naringin","a3","L6400-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.",580.53,"10236-47-2",{"v":100,"d":"100.00"},172.26,"<1","N/A","http://selleckchem.com/products/Naringin(Naringoside).html","C27H32O14","free base","Naringoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C=C5)O)C(O)C(O)C1O",-0.415,6,8,6]
["S2331","Neohesperidin Dihydrochalcone (Nhdc)","b3","L6400-02","in 10mM DMSO","Others","Others","Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.",612.58,"20702-77-6",{"v":100,"d":"100.00"},163.24,"<1","N/A","http://selleckchem.com/products/Neohesperidin-dihydrochalcone(Nhdc).html","C28H36O15","free base","NCI-c60764","COC1=C(O)C=C(CCC(=O)C2=C(O)C=C(OC3OC(CO)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C=C2O)C=C1",-0.048,6,9,10]
["S2332","Neohesperidin","c3","L6400-02","in 10mM DMSO","ROS","Immunology & Inflammation","Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent., Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。",610.56,"13241-33-3",{"v":122,"d":"122.00"},199.82,"<1","N/A","http://selleckchem.com/products/Neohesperidin.html","C28H34O15","free base","NSC 31048","COC1=CC(=CC(=C1)C2CC(=O)C3=C(O)C=C(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)C=C3O2)O",-0.431,7,8,7]
["S2333","Nobiletin (NSC 76751)","d3","L6400-02","in 10mM DMSO","MMP","Proteases","Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.",402.39,"478-01-3",{"v":81,"d":"81.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/Nobiletin(Hexamethoxyflavone).html","C21H22O8","free base","Hexamethoxyflavone","COC1=C(OC)C=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.038,8,0,7]
["S2341","(-)-Parthenolide","e3","L6400-02","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2342","Phloretin (RJC 02792)","f3","L6400-02","in 10mM DMSO","SGLT","GPCR & G Protein","Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.",274.27,"60-82-2",{"v":54,"d":"54.00"},196.89,"<1","N/A","http://selleckchem.com/products/Phloretin(Dihydronaringenin).html","C15H14O5","free base","NSC 407292, Dihydronaringenin","OC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1",2.757,1,4,4]
["S2347","Quercetin Dihydrate","g3","L6400-02","in 10mM DMSO","PI3K,Sirtuin","PI3K/Akt/mTOR","Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.",338.27,"6151-25-3",{"v":67,"d":"67.00"},198.07,"<1","N/A","http://selleckchem.com/products/Quercetin-dihydrate(Sophoretin).html","C15H10O7.2H2O","Dihydrate","Sophoretin","O.O.OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",1.216,2,5,1]
["S2348","Rotenone (Barbasco)","h3","L6400-02","in 10mM DMSO","Apoptosis related,Mitochondrial Metabolism,Mitophagy,NADPH-oxidase,ROS","Immunology & Inflammation","Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.",394.42,"83-79-4",{"v":78,"d":"78.00"},197.76,"N/A","N/A","http://selleckchem.com/products/rotenone-barbasco.html","C23H22O6","free base","Barbasco, Dactinol, Paraderil, Rotenon, Rotocide","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C(C=CC5=C4CC(O5)C(C)=C)C3=O",{"v":3.93,"d":"3.930"},6,0,3]
["S2350","Rutin","a4","L6400-02","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1","N/A","http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2354","Sclareol","b4","L6400-02","in 10mM DMSO","Others","Others","Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.",{"v":308.5,"d":"308.50"},"515-03-7",{"v":61,"d":"61.00"},197.73,"<1","N/A","http://selleckchem.com/products/Sclareol.html","C20H36O2","free base","N/A","CC1(C)CCCC2(C)C1CCC(C)(O)C2CCC(C)(O)C=C",{"v":4.27,"d":"4.270"},0,0,4]
["S2357","Silibinin (NSC 651520)","c4","L6400-02","in 10mM DMSO","Others","Others","Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.",482.44,"22888-70-6",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silibinin(Silybin).html","C25H22O10","free base","Silybin, Silibinin A, Silymarin I, Flavobin","COC1=CC(=CC=C1O)C2OC3=CC(=CC=C3OC2CO)C4OC5=CC(=CC(=C5C(=O)C4O)O)O",2.592,5,5,4]
["S2358","Silymarin","d4","L6400-02","in 10mM DMSO","Antioxidant","Angiogenesis","Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.",482.44,"65666-07-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silymarin(Silybin-B).html","C25H22O10","free base","Silybin B","COC1=CC(=CC=C1O)C2OC3=CC=C(C=C3OC2CO)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S2363","Tangeretin","e4","L6400-02","in 10mM DMSO","Antioxidant","Apoptosis","Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.",372.37,"481-53-8",{"v":8,"d":"8.00"},21.48,"<1","N/A","http://selleckchem.com/products/Tangeretin(Tangeritin).html","C20H20O7","free base","Tangeritin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.054,7,0,6]
["S2365","Tanshinone IIA","f4","L6400-02","in 10mM DMSO","Lipase","Metabolism","Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.",294.34,"568-72-9",{"v":5,"d":"5.00"},16.99,"<1","N/A","http://selleckchem.com/products/Tanshinone-IIA(Tanshinone-B).html","C19H18O3","free base","Tanshinone B","CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C",{"v":4.66,"d":"4.660"},3,0,0]
["S2369","Troxerutin","g4","L6400-02","in 10mM DMSO","NLR,ROS","Immunology & Inflammation","Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.",742.68,"7085-55-4",{"v":100,"d":"100.00"},134.65,{"v":100,"d":"100.00"},134.65,"http://selleckchem.com/products/Troxerutin.html","C33H42O19","free base","N/A","CC1OC(OCC2OC(OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(OCCO)C=C5)OCCO)C(O)C(O)C2O)C(O)C(O)C1O",{"v":-2.1,"d":"-2.100"},9,10,15]
["S2375","Aloin","h4","L6400-02","in 10mM DMSO","Tyrosinase","Proteases","Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.",418.39,"1415-73-2",{"v":83,"d":"83.00"},198.38,{"v":83,"d":"83.00"},198.38,"http://selleckchem.com/products/Aloin(Barbaloin).html","C21H22O9","free base","Barbaloin, Barbalin","OCC1OC(C(O)C(O)C1O)C2C3=C(C(=CC=C3)O)C(=O)C4=C2C=C(CO)C=C4O",-0.404,2,7,3]
["S2389","Naringin Dihydrochalcone","a5","L6400-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.",582.55,"18916-17-1",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://selleckchem.com/products/Naringin-Dihydrochalcone(Naringin-DC).html","C27H34O14","free base","N/A","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C(C(=O)CCC4=CC=C(O)C=C4)C(=C3)O)O)C(O)C(O)C1O",-0.032,5,9,9]
["S2391","Quercetin (NSC 9221)","b5","L6400-02","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src","Epigenetics","Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.",302.24,"117-39-5",{"v":61,"d":"61.00"},201.83,"<1","N/A","http://selleckchem.com/products/Quercetin(Sophoretin).html","C15H10O7","Free Base","Sophoretin, C.I. 75720","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S2394","Naringenin","c5","L6400-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.",272.25,"480-41-1",{"v":54,"d":"54.00"},198.35,"<1","N/A","http://selleckchem.com/products/naringenin.html","C15H12O5","free base","NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["S2396","Salidroside","d5","L6400-02","in 10mM DMSO","Mitophagy,mTOR,PREP","PI3K/Akt/mTOR","Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.",{"v":300.3,"d":"300.30"},"10338-51-9",{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Salidroside-Rhodioloside.html","C14H20O7","free base","Rhodioloside","OCC1OC(OCCC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.443,2,5,5]
["S2397","Palmatine chloride","e5","L6400-02","in 10mM DMSO","Calcium Channel","Neuronal Signaling","Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.",387.86,"10605-02-4",{"v":77,"d":"77.00"},198.53,{"v":5,"d":"5.00"},12.89,"http://selleckchem.com/products/Palmatine-chloride.html","C21H22NO4.Cl","Chloride","N/A","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC",1.488,4,0,4]
["S2399","Dihydromyricetin","f5","L6400-02","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2400","Rheic Acid","g5","L6400-02","in 10mM DMSO","FTO,Immunology & Inflammation related","Immunology & Inflammation","Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.",284.22,"478-43-3",{"v":3,"d":"3.00"},10.56,"<1","N/A","http://www.selleck.cn/products/Rhein-Monorhein.html","C15H8O6","Free Base","Rhein, Monorhein, NSC 38629, Rheinic Acid","OC(=O)C1=CC(=C2C(=O)C3=C(C=CC=C3O)C(=O)C2=C1)O",1.954,3,2,1]
["S2401","Sodium Danshensu","h5","L6400-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.",220.15,"67920-52-9",{"v":7,"d":"7.00"},{"v":31.8,"d":"31.80"},{"v":2,"d":"2.00"},9.08,"http://selleckchem.com/products/Sodium-Danshensu.html","C9H9O5.Na","Sodium Salt","N/A","[Na+].OC(CC1=CC(=C(O)C=C1)O)C([O-])=O",-0.795,0,3,3]
["S2405","Sophocarpine","a6","L6400-02","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.",246.35,"6483-15-4",{"v":49,"d":"49.00"},{"v":198.9,"d":"198.90"},{"v":6,"d":"6.00"},24.36,"http://selleckchem.com/products/Sophocarpine.html","C15H22N2O","free base","N/A","O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.394,1,0,0]
["S2411","Geniposide","b6","L6400-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis.",388.37,"24512-63-8",{"v":78,"d":"78.00"},200.84,{"v":78,"d":"78.00"},200.84,"http://selleckchem.com/products/geniposide.html","C17H24O10","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C1CC=C3CO",-2.066,5,5,6]
["S2413","Geniposidic acid","c6","L6400-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.",374.34,"27741-01-1",{"v":16,"d":"16.00"},42.74,"<1","N/A","http://selleckchem.com/products/geniposidic-acid.html","C16H22O10","free base","N/A","OCC1OC(OC2OC=C(C3CC=C(CO)C23)C(O)=O)C(O)C(O)C1O",-2.291,4,5,5]
["S2415","Astragaloside A","d6","L6400-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.",784.97,"83207-58-3",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://selleckchem.com/products/astragaloside-a.html","C41H68O14","free base","N/A","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O",-0.348,5,8,7]
["S2450","Equol","e6","L6400-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.",242.27,"531-95-3",{"v":48,"d":"48.00"},198.13,"<1","N/A","http://selleckchem.com/products/equol.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=CC(=CC=C3C2)O",3.211,1,2,1]
["S2460","Pramipexole","f6","L6400-02","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.",211.33,"104632-26-0",{"v":42,"d":"42.00"},198.74,"<1","N/A","http://selleckchem.com/products/Pramipexole-Mirapex.html","C10H17N3S","Free Base","SND 919,Mirapexin,Sifrol,Mirapex","CCCNC1CCC2=C(C1)SC(=N2)N",1.383,1,2,3]
["S2505","Rosiglitazone (BRL-49653) maleate","g6","L6400-02","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",{"v":473.5,"d":"473.50"},"155141-29-0",{"v":94,"d":"94.00"},198.52,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-maleate.html","C18H19N3O3S.C4H4O4","Maleate","BRL-49653C","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=NC=CC=C3.OC(=O)\\C=C/C(O)=O",3.307,6,1,9]
["S2526","Alizarin","h6","L6400-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.",240.21,"72-48-0",{"v":48,"d":"48.00"},199.83,"<1","N/A","http://selleckchem.com/products/Alizarin.html","C14H8O4","free base","Anthraquinonic","OC1=C(O)C2=C(C=C1)C(=O)C3=CC=CC=C3C2=O",2.324,2,2,0]
["S2528","Ciclopirox","a7","L6400-02","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator.",207.27,"29342-05-0",{"v":42,"d":"42.00"},202.63,"<1","N/A","http://selleckchem.com/products/Ciclopirox-Penlac.html","C12H17NO2","Free Base","HOE 296b, Penlac","CC1=CC(=O)N(O)C(=C1)C2CCCCC2",2.489,1,0,1]
["S2532","L-Ascorbyl 6-palmitate","b7","L6400-02","in 10mM DMSO","N/A","Others","Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.",414.53,"137-66-6",{"v":83,"d":"83.00"},200.23,"<1","N/A","http://selleckchem.com/products/L-Ascorbyl-6-palmitate.html","C22H38O7","free base","N/A","CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(=C1O)O",5.268,4,3,18]
["S2556","Rosiglitazone (BRL 49653)","c7","L6400-02","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",357.43,"122320-73-4",{"v":71,"d":"71.00"},198.64,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-Avandia.html","C18H19N3O3S","Free Base","BRL 49653","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",3.268,4,1,7]
["S2586","Dimethyl Fumarate","d7","L6400-02","in 10mM DMSO","Nrf2","Immunology & Inflammation","Dimethyl fumarate (DMF,Tecfidera,BG-12) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.",144.13,"624-49-7",{"v":29,"d":"29.00"},201.21,"<1","N/A","http://selleckchem.com/products/dimethyl-Fumarate.html","C6H8O4","free base","DMF,Tecfidera,BG-12","COC(=O)\\C=C\\C(=O)OC",{"v":0.49,"d":"0.490"},4,0,4]
["S2590","Pioglitazone (AD-4833)","e7","L6400-02","in 10mM DMSO","PPAR","Metabolism","Pioglitazone (AD-4833, U 72107) is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ.",356.44,"111025-46-8",{"v":10,"d":"10.00"},28.06,"<1","N/A","https://www.selleckchem.com/products/pioglitazone.html","C19H20N2O3S","Free Base","U 72107","CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",3.907,4,1,7]
["S2605","Idebenone","f7","L6400-02","in 10mM DMSO","ROS","Immunology & Inflammation","Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.",338.44,"58186-27-9",{"v":68,"d":"68.00"},200.92,"<1","N/A","http://selleckchem.com/products/idebenone.html","C19H30O5","free base","CV-2619","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCCO",3.836,4,1,12]
["S2617","TAK-733","g7","L6400-02","in 10mM DMSO","MEK","MAPK","TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.",504.23,"1035555-63-5",{"v":101,"d":"101.00"},200.31,"<1","N/A","http://selleckchem.com/products/tak-733.html","C17H15F2IN4O4","free base","N/A","CN1C(=O)C(=C(NC2=CC=C(I)C=C2F)C3=C1N=CN(CC(O)CO)C3=O)F",0.383,3,3,5]
["S2664","Clinofibrate","h7","L6400-02","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.",468.58,"30299-08-2",{"v":94,"d":"94.00"},200.61,"<1","N/A","http://selleckchem.com/products/clinofibrate.html","C28H36O6","free base","N/A","CCC(C)(OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(OC(C)(CC)C(O)=O)C=C3)C(O)=O",6.829,4,0,10]
["S2720","ZM 336372","a8","L6400-02","in 10mM DMSO","Raf","MAPK","ZM 336372 (Zinc00581684) is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.",389.45,"208260-29-1",{"v":78,"d":"78.00"},200.28,"<1","N/A","http://selleckchem.com/products/zm-336372.html","C23H23N3O3","free base","Zinc00581684","CN(C)C1=CC=CC(=C1)C(=O)NC2=CC(=C(C)C=C2)NC(=O)C3=CC=C(O)C=C3",3.805,2,3,5]
["S2721","Nilvadipine","b8","L6400-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nilvadipine (ARC029, FR34235,FK235) is a potent calcium channel blocker with an IC50 of 0.03 nM.",385.37,"75530-68-6",{"v":77,"d":"77.00"},199.81,"<1","N/A","http://selleckchem.com/products/nilvadipine-arc029.html","C19H19N3O6","free base","ARC029, FR34235,FK235","COC(=O)C1=C(NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C)C#N",2.087,4,1,7]
["S2746","AZ 628","c8","L6400-02","in 10mM DMSO","Apoptosis related,Raf","MAPK","AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.",451.52,"878739-06-1",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://selleckchem.com/products/az628.html","C27H25N5O2","free base","N/A","CN1C=NC2=C(C=C(NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)C=C2)C1=O",{"v":4.57,"d":"4.570"},3,2,5]
["S2747","AMG-458","d8","L6400-02","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.",539.58,"913376-83-7",{"v":21,"d":"21.00"},38.92,"<1","N/A","http://selleckchem.com/products/amg458.html","C30H29N5O5","free base","N/A","COC1=CC2=NC=CC(=C2C=C1)OC3=CN=C(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)C5=CC=CC=C5)C=C3",3.125,6,1,8]
["S2781","RITA (NSC 652287)","e8","L6400-02","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2797","Lonafarnib (SCH66336)","f8","L6400-02","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2843","BI-D1870","g8","L6400-02","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2910","Tempol","h8","L6400-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.",172.24,"2226-96-2",{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},"http://selleckchem.com/products/tempol-4-hydroxy-tempo.html","C9H18NO2","free base","4-Hydroxy-TEMPO","CC1(C)CC(O)CC(C)(C)N1[O]",0.413,0,1,0]
["S2926","TDZD-8","a9","L6400-02","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.",222.26,"327036-89-5",{"v":44.5,"d":"44.50"},200.22,"<1","N/A","http://selleckchem.com/products/tdzd-8.html","C10H10N2O2S","free base","NP 01139","CN1SC(=O)N(CC2=CC=CC=C2)C1=O",2.145,2,0,2]
["S2929","Pifithrin-α (PFTα) HBr","b9","L6400-02","in 10mM DMSO","AhR,Autophagy,p53","Apoptosis","Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).",{"v":367.3,"d":"367.30"},"63208-82-2",{"v":67,"d":"67.00"},182.41,"<1","N/A","http://selleckchem.com/products/pifithrin-alpha.html","C16H18N2OS.HBr","HBr","Pifithrin-α hydrobromide","Br.CC1=CC=C(C=C1)C(=O)CN2C(=N)SC3=C2CCCC3",3.993,1,0,3]
["S2930","Pifithrin-μ","c9","L6400-02","in 10mM DMSO","Autophagy,HSP (HSP90),p53","Apoptosis","Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.",181.21,"64984-31-2",{"v":36,"d":"36.00"},198.66,"<1","N/A","http://selleckchem.com/products/pifithrin-u.html","C8H7NO2S","free base","NSC 303580, PFTμ, 2-Phenylethynesulfonamide","N[S](=O)(=O)C#CC1=CC=CC=C1",0.825,2,1,2]
["S3019","Ciclopirox ethanolamine","d9","L6400-02","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator.",268.35,"41621-49-2",{"v":6,"d":"6.00"},22.36,"<1","N/A","http://selleckchem.com/products/ciclopirox-ethanolamine.html","C12H17NO2.C2H7NO","Ethanolamine","Ciclopirox olamine, HOE 296,Ciclopiroxolamine","CC1=CC(=O)N(O)C(=C1)C2CCCCC2.NCCO",1.302,1,2,2]
["S3031","Linagliptin (BI-1356)","e9","L6400-02","in 10mM DMSO","Autophagy,Ferroptosis","Proteases","Linagliptin (BI-1356,GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.",472.54,"668270-12-0",{"v":17,"d":"17.00"},35.98,"<1","N/A","http://selleckchem.com/products/linagliptin-bi-1356.html","C25H28N8O2","free base","GSK2118436","CC#CC[N]1C(=NC2=C1C(=O)N(CC3=NC4=CC=CC=C4C(=N3)C)C(=O)N2C)N5CCCC(N)C5",2.718,5,1,5]
["S3033","Vildagliptin (LAF-237)","f9","L6400-02","in 10mM DMSO","DPP","Proteases","Vildagliptin (LAF-237,NVP-LAF 237) inhibits DPP−4 with IC50 of 2.3 nM.",{"v":303.4,"d":"303.40"},"274901-16-5",{"v":60,"d":"60.00"},197.76,{"v":60,"d":"60.00"},197.76,"http://selleckchem.com/products/vildagliptin-laf-237.html","C17H25N3O2","free base","NVP-LAF 237","O[C]12CC3[CH2]C(C1)C[C](C3)(C2)NCC(=O)N4CCCC4C#N",0.179,1,1,3]
["S3036","Pravastatin sodium","g9","L6400-02","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.",446.51,"81131-70-6",{"v":89,"d":"89.00"},199.32,{"v":89,"d":"89.00"},199.32,"http://selleckchem.com/products/pravastatin-pravachol.html","C23H35O7.Na","sodium","CS-514 Sodium","[Na+].CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC([O-])=O)C12",0.682,2,3,11]
["S3077","Tazobactam","h9","L6400-02","in 10mM DMSO","Selection Antibiotics for Transfected Cell,β-lactamase","Microbiology","Tazobactam (Tazobactam acid, Tazobactamum) is a β-lactamases Inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect.",300.29,"89786-04-9",{"v":60,"d":"60.00"},199.81,"<1","N/A","http://selleckchem.com/products/tazobactam.html","C10H12N4O5S","free base","Tazobactam acid, Tazobactamum","CC1(C[N]2C=CN=N2)C(N3C(CC3=O)[S]1(=O)=O)C(O)=O",-1.189,6,0,3]
["S3113","Pyridoxine HCl","a10","L6400-02","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine HCl (Vitamin B6,Pyridoxol hydrochloride) is a form of vitamin B6.",205.64,"58-56-0",{"v":41,"d":"41.00"},199.38,{"v":41,"d":"41.00"},199.38,"http://selleckchem.com/products/pyridoxine-hydrochloride.html","C8H11NO3.HCl","Hydrochloride","Vitamin B6,Pyridoxol hydrochloride","Cl.CC1=C(O)C(=C(CO)C=N1)CO",-0.108,1,3,2]
["S3114","Vitamin C","b10","L6400-02","in 10mM DMSO","Vitamin","Metabolism","Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.",176.12,"50-81-7",{"v":35,"d":"35.00"},198.73,{"v":35,"d":"35.00"},198.73,"http://selleckchem.com/products/vitamin-c-ascorbic-acid.html","C6H8O6","free base","L-Ascorbic acid","OCC(O)C1OC(=O)C(=C1O)O",-1.709,2,4,2]
["S3600","Schisandrin B (Sch B)","c10","L6400-02","in 10mM DMSO","ATM/ATR,P-gp","PI3K/Akt/mTOR","Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.",400.46,"61281-37-6",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://selleckchem.com/products/schisandrin-b.html","C23H28O6","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C4OCOC4=C3OC",5.067,6,0,4]
["S3609","Berbamine dihydrochloride","d10","L6400-02","in 10mM DMSO","Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",681.65,"6078-17-7",{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},"http://selleckchem.com/products/berbamine-dihydrochloride.html","C37H40N2O6.2HCl","dihydrochloride","BA, BBM","Cl.Cl.COC1=CC2=C3C=C1OC4=C(OC)C(=CC5=C4C(CC6=CC(=C(O)C=C6)OC7=CC=C(CC3N(C)CC2)C=C7)N(C)CC5)OC",7.756,5,1,3]
["S3612","Rosmarinic acid","e10","L6400-02","in 10mM DMSO","Complement System,IκB/IKK","NF-κB","Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.",360.31,"20283-92-5",{"v":72,"d":"72.00"},199.83,{"v":24,"d":"24.00"},66.61,"http://selleckchem.com/products/rosmarinic-acid.html","C18H16O8","free base","Rosemary acid","OC(=O)C(CC1=CC=C(O)C(=C1)O)OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O",2.706,3,4,7]
["S3613","Scoparone","f10","L6400-02","in 10mM DMSO","Others","Others","Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone) is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions.",206.19,"120-08-1",{"v":41,"d":"41.00"},198.85,"<1","N/A","http://selleckchem.com/products/scoparone.html","C11H10O4","free base","6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone","COC1=CC2=C(C=CC(=O)O2)C=C1OC",1.866,4,0,2]
["S3616","Asiaticoside","g10","L6400-02","in 10mM DMSO","ROS","Immunology & Inflammation","Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.",959.12,"16830-15-2",{"v":100,"d":"100.00"},104.26,"<1","N/A","http://selleckchem.com/products/asiaticoside.html","C48H78O19","free base","Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O",-0.101,7,12,10]
["S3617","(20S)-Protopanaxatriol","h10","L6400-02","in 10mM DMSO","Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).",476.73,"34080-08-5",{"v":95,"d":"95.00"},199.27,"<1","N/A","http://selleckchem.com/products/20s-protopanaxatriol.html","C30H52O4","free base","g-PPT, 20(S)-APPT","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(O)CC23C",{"v":4.62,"d":"4.620"},0,3,4]
["S3624","Quinolinic acid","a11","L6400-02","in 10mM DMSO","NMDAR","Neuronal Signaling","Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.",167.12,"89-00-9",{"v":25,"d":"25.00"},149.59,{"v":3,"d":"3.00"},17.95,"http://selleckchem.com/products/quinolinic-acid.html","C7H5NO4","free base","pyridine-2,3-dicarboxylic acid, QUIN","OC(=O)C1=CC=CN=C1C(O)=O",0.367,3,0,2]
["S3626","Sesamol","b11","L6400-02","in 10mM DMSO","Antioxidant","Apoptosis","Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.",138.12,"533-31-3",{"v":27,"d":"27.00"},195.48,{"v":27,"d":"27.00"},195.48,"http://selleckchem.com/products/sesamol.html","C7H6O3","free base","1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol","OC1=CC2=C(OCO2)C=C1",1.356,2,1,0]
["S3629","Syringic acid","c11","L6400-02","in 10mM DMSO","Antioxidant","Angiogenesis","Syringic acid (NSC 2129, SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.",198.17,"530-57-4",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},{"v":1,"d":"1.00"},5.05,"http://selleckchem.com/products/syringic-acid.html","C9H10O5","free base","3,5-dimethyl ether Gallic Acid, 3,5-dimethoxy-4-hydroxy Benzoic Acid, NSC 2129, SYRA","COC1=CC(=CC(=C1O)OC)C(O)=O",1.184,3,1,3]
["S3630","Methyl Vanillate","d11","L6400-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.",182.17,"3943-74-6",{"v":36,"d":"36.00"},197.62,{"v":12,"d":"12.00"},65.87,"http://selleckchem.com/products/methyl-vanillate.html","C9H10O4","free base","N/A","COC(=O)C1=CC(=C(O)C=C1)OC",1.426,3,1,3]
["S3639","Tacrine hydrochloride hydrate","e11","L6400-02","in 10mM DMSO","AChR,HNMT","Neuronal Signaling","Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.","198.26(free bases)","206658-92-6",{"v":50,"d":"50.00"},252.19,{"v":50,"d":"50.00"},252.19,"http://selleckchem.com/products/tacrine-hydrochloride-hydrate.html","C13H14N2.xHCl.xH2O","hydrochloride hydrate","Tacrine, Tetrahydroaminacrine, Tetrahydroaminoacridine","NC1=C2C=CC=CC2=NC3=C1CCCC3",4.258,1,1,0]
["S3652","3-Nitropropionic acid","f11","L6400-02","in 10mM DMSO","Dehydrogenase","Metabolism","3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.",119.08,"504-88-1",{"v":23,"d":"23.00"},193.15,{"v":23,"d":"23.00"},193.15,"http://selleckchem.com/products/3-nitropropionic-acid.html","C3H5NO4","free base","β-Nitropropionic Acid, 3-NP","OC(=O)CC[N+]([O-])=O",{"v":0.02,"d":"0.020"},1,0,3]
["S3665","Trolox","g11","L6400-02","in 10mM DMSO","Vitamin","Metabolism","Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.",250.29,"53188-07-1",{"v":50,"d":"50.00"},199.77,"<1","N/A","http://selleckchem.com/products/trolox.html","C14H18O4","free base","N/A","CC1=C(C)C2=C(CCC(C)(O2)C(O)=O)C(=C1O)C",3.489,2,1,1]
["S3671","Quinestrol","h11","L6400-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.",364.52,"152-43-2",{"v":72,"d":"72.00"},197.52,"<1","N/A","http://selleckchem.com/products/quinestrol.html","C25H32O2","free base","Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566","CC12CCC3C(CCC4=C3C=CC(=C4)OC5CCCC5)C1CCC2(O)C#C",6.514,1,0,2]
["S3675","Umbelliferone","a2","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.",162.14,"93-35-6",{"v":32,"d":"32.00"},197.36,"<1","N/A","http://selleckchem.com/products/umbelliferone.html","C9H6O3","free base","7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone","OC1=CC2=C(C=C1)C=CC(=O)O2",1.657,2,1,0]
["S3679","Flavanone","b2","L6400-03","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties.",224.25,"487-26-3",{"v":44,"d":"44.00"},196.21,"<1","N/A","http://selleckchem.com/products/flavanone.html","C15H12O2","free base","2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one","O=C1CC(OC2=C1C=CC=C2)C3=CC=CC=C3",3.099,2,0,1]
["S3681","Vitamin E Acetate","c2","L6400-03","in 10mM DMSO","Vitamin","Metabolism","Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant., Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. ,",472.74,"58-95-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e-acetate.html","C31H52O3","free base","Tocopherol acetate","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)OC(C)=O",{"v":10.45,"d":"10.450"},3,0,14]
["S3694","Glucosamine hydrochloride","d2","L6400-03","in 10mM DMSO","Others","Immunology & Inflammation","Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.",215.63,"66-84-2",{"v":4,"d":"4.00"},18.55,{"v":43,"d":"43.00"},199.42,"http://selleckchem.com/products/glucosamine-hydrochloride.html","C6H13NO5.HCl","hydrochloride","2-Amino-2-deoxy-glucose HCl, Chitosamine HCl","Cl.NC1C(O)OC(CO)C(O)C1O",-2.422,1,4,1]
["S3764","Isoferulic Acid","e2","L6400-03","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties.  Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.",194.18,"537-73-5",{"v":38,"d":"38.00"},195.69,"N/A","N/A","http://selleckchem.com/products/isoferulic-acid.html","C10H10O4","free base","Hesperetic acid, Hesperetate, Isoferulate","COC1=C(O)C=C(\\C=C\\C(O)=O)C=C1",1.669,2,1,3]
["S3765","Picroside II","f2","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.",512.46,"39012-20-9",{"v":100,"d":"100.00"},195.14,"N/A","N/A","http://selleckchem.com/products/picroside-ii.html","C23H28O13","free base","6-Vanilloylcatalpol, Vanilloyl catalpol","COC1=CC(=CC=C1O)C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C5(CO)OC25",-1.796,7,6,8]
["S3769","Palmatine","g2","L6400-03","in 10mM DMSO","AChR","Neuronal Signaling","Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.",{"v":352.4,"d":"352.40"},"3486-67-7",{"v":70,"d":"70.00"},198.64,"N/A","N/A","http://selleckchem.com/products/palmatine.html","C21H22NO4","free base","Berbericinine, Burasaine","COC1=CC2=C(C=C1OC)C3=CC4=C(C=[N+]3CC2)C(=C(OC)C=C4)OC",4.161,4,0,4]
["S3771","Stachydrine","h2","L6400-03","in 10mM DMSO","NF-κB","NF-κB","Stachydrine (Proline betaine, L-stachydrine, Methyl hygrate betaine) is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.",143.18,"471-87-4",{"v":28,"d":"28.00"},195.56,"N/A","N/A","http://selleckchem.com/products/stachydrine.html","C7H13NO2","inner salt","Proline betaine, L-stachydrine, Methyl hygrate betaine","C[N+]1(C)CCCC1C([O-])=O",-2.431,0,0,1]
["S3773","Tyrosol","a3","L6400-03","in 10mM DMSO","NF-κB","NF-κB","Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.  Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.",138.16,"501-94-0",{"v":27,"d":"27.00"},195.43,"N/A","N/A","http://selleckchem.com/products/tyrosol.html","C8H10O2","free base","4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol","OCCC1=CC=C(O)C=C1",1.304,0,2,2]
["S3775","Ligustrazine hydrochloride","b3","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.",172.66,"76494-51-4",{"v":34,"d":"34.00"},196.92,"N/A","N/A","http://selleckchem.com/products/ligustrazine-hydrochloride.html","C8H12N2.HCl","hydrochloride","Tetramethylpyrazine HCl, Tetrapyrazine HCl","Cl.CC1=NC(=C(C)N=C1C)C",1.041,2,0,0]
["S3777","Gentiopicroside","c3","L6400-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Gentiopicroside (GE, Gentiopicrin), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and  dose not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities.",356.32,"20831-76-9",{"v":71,"d":"71.00"},199.26,"N/A","N/A","http://selleckchem.com/products/gentiopicroside.html","C16H20O9","free base","Gentiopicrin","OCC1OC(OC2OC=C3C(=O)OCC=C3C2C=C)C(O)C(O)C1O",-1.523,5,4,4]
["S3780","Secoisolariciresinol diglucoside","d3","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.",{"v":686.7,"d":"686.70"},"148244-82-0",{"v":100,"d":"100.00"},145.62,{"v":100,"d":"100.00"},145.62,"http://selleckchem.com/products/secoisolariciresinol-diglucoside.html","C32H46O16","free base","N/A","COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC",-0.651,6,10,15]
["S3783","Echinacoside","e3","L6400-03","in 10mM DMSO","Tyrosinase","Protein Tyrosine Kinase","Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.",786.73,"82854-37-3",{"v":100,"d":"100.00"},127.11,"N/A","N/A","http://selleckchem.com/products/echinacoside.html","C35H46O20","free base","N/A","CC1OC(OC2C(O)C(OCCC3=CC(=C(O)C=C3)O)OC(COC4OC(CO)C(O)C(O)C4O)C2OC(=O)\\C=C\\C5=CC=C(O)C(=C5)O)C(O)C(O)C1O",-1.263,8,12,14]
["S3784","Obacunone (AI3-37934)","f3","L6400-03","in 10mM DMSO","Aromatase,Nrf2","Endocrinology & Hormones","Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.",454.51,"751-03-1",{"v":90,"d":"90.00"},198.02,"N/A","N/A","http://selleckchem.com/products/obacunone.html","C26H30O7","free base","CCRIS 8657","CC1(C)OC(=O)C=CC2(C)C3CCC4(C)C(OC(=O)C5OC45C3(C)C(=O)CC12)C6=COC=C6",2.715,7,0,1]
["S3785","Notoginsenoside R1","g3","L6400-03","in 10mM DMSO","Akt,ERK,PAI-1,PI3K","Metabolism","Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.",933.13,"80418-24-2",{"v":100,"d":"100.00"},107.17,"N/A","N/A","http://selleckchem.com/products/notoginsenoside-r1.html","C47H80O18","free base","Sanchinoside R1, NG-R1, NGR1","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(CO)C(O)C(O)C6OC7OCC(O)C(O)C7O",{"v":-0.11,"d":"-0.110"},6,12,12]
["S3786","Glabridin","h3","L6400-03","in 10mM DMSO","GABA Receptor,PPAR","Metabolism","Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.",324.37,"59870-68-7",{"v":64,"d":"64.00"},197.31,"N/A","N/A","http://selleckchem.com/products/glabridin.html","C20H20O4","free base","Q-100692, KB-289522, LS-176045","CC1(C)OC2=C(C=C1)C3=C(CC(CO3)C4=CC=C(O)C=C4O)C=C2",3.999,2,2,1]
["S3788","Carvacrol","a4","L6400-03","in 10mM DMSO","AChR","Neuronal Signaling","Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.",150.22,"499-75-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carvacrol.html","C10H14O","free base","cymophenol","CC(C)C1=CC=C(C)C(=C1)O",3.268,0,1,1]
["S3790","Methyl gallate","b4","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.",184.15,"99-24-1",{"v":36,"d":"36.00"},359.57,"N/A","N/A","http://selleckchem.com/products/methyl-gallate.html","C8H8O5","free base","Methylgallate, Gallic acid methyl ester, Gallicin","COC(=O)C1=CC(=C(O)C(=C1)O)O",0.959,2,3,2]
["S3799","Gentisic acid","c4","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Gentisic acid (2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Hydroquinonecarboxylic acid, DHB), an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.",154.12,"490-79-9",{"v":30,"d":"30.00"},194.65,"N/A","N/A","http://selleckchem.com/products/gentisic-acid.html","C7H6O4","free base","DHB, 2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Gentianic acid, Carboxyhydroquinone, Hydroquinonecarboxylic acid","OC(=O)C1=C(O)C=CC(=C1)O",0.975,1,2,1]
["S3802","Trigonelline Hydrochloride","d4","L6400-03","in 10mM DMSO","Bacterial","Microbiology","Trigonelline (Nicotinic acid N-methylbetaine, Coffearine, Gynesine), a major alkaloid component of fenugreek, has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and also has been shown to reduce diabetic auditory neuropathy and platelet aggregation.",{"v":173.6,"d":"173.60"},"6138-41-6",{"v":18,"d":"18.00"},103.69,"N/A","N/A","http://selleckchem.com/products/trigonelline-hydrochloride.html","C7H8NO2.Cl","chloride","Nicotinic acid N-methylbetaine Hydrochloride, Coffearine Hydrochloride, Gynesine Hydrochloride","[Cl-].C[N+]1=CC(=CC=C1)C(O)=O",{"v":-1.61,"d":"-1.610"},1,0,1]
["S3804","Alpha-Mangostin","e4","L6400-03","in 10mM DMSO","Dehydrogenase,STING","Metabolism","Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities.    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.",410.46,"6147-11-1",{"v":82,"d":"82.00"},199.78,"N/A","N/A","http://selleckchem.com/products/alpha-mangostin.html","C24H26O6","free base","N/A","COC1=C(O)C=C2OC3=C(C(=C(CC=C(C)C)C(=C3)O)O)C(=O)C2=C1CC=C(C)C",5.935,3,3,5]
["S3808","Mangiferin","f4","L6400-03","in 10mM DMSO","NF-κB,Nrf2","Immunology & Inflammation","Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.",422.34,"4773-96-0",{"v":84,"d":"84.00"},198.89,"N/A","N/A","http://selleckchem.com/products/mangiferin.html","C19H18O11","free base","Alpizarin, Chinomin, Hedysarid","OCC1OC(C(O)C(O)C1O)C2=C(O)C=C3OC4=C(C=C(O)C(=C4)O)C(=O)C3=C2O",-0.396,3,8,2]
["S3810","Scutellarin","g4","L6400-03","in 10mM DMSO","Akt,NF-κB,STAT","JAK/STAT","Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.",462.36,"27740-01-8",{"v":50,"d":"50.00"},108.14,"N/A","N/A","http://selleckchem.com/products/scutellarin.html","C21H18O12","free base","Breviscapine, Breviscapin, Scutellarein-7-glucuronide","OC1C(O)C(OC(C1O)C(O)=O)OC2=CC3=C(C(=O)C=C(O3)C4=CC=C(O)C=C4)C(=C2O)O",0.366,5,6,4]
["S3811","Ginsenoside Re","h4","L6400-03","in 10mM DMSO","Beta Amyloid,JNK,NF-κB","Neuronal Signaling","Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.",947.15,"52286-59-6",{"v":100,"d":"100.00"},105.58,"N/A","N/A","http://selleckchem.com/products/ginsenoside-re.html","C48H82O18","free base","Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc","CC1OC(OC2C(O)C(O)C(CO)OC2OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C1O",0.267,6,12,12]
["S3813","Bakuchiol","a5","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.",256.38,"10309-37-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/bakuchiol.html","C18H24O","free base","(S)-(+)-Bakuchiol","CC(C)=CCCC(C)(C=C)\\C=C\\C1=CC=C(O)C=C1",5.348,0,1,6]
["S3815","Mogroside V","b5","L6400-03","in 10mM DMSO","Others","Others","Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).",1287.43,"88901-36-4",{"v":100,"d":"100.00"},77.67,"N/A","N/A","http://selleckchem.com/products/mogroside-v.html","C60H102O29","free base","N/A","CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1OC3OC(CO)C(O)C(O)C3O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C",{"v":-3.98,"d":"-3.980"},10,18,20]
["S3816","Dehydroevodiamine","c5","L6400-03","in 10mM DMSO","COX,NF-κB,PGES,ROS","Immunology & Inflammation","Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.",301.34,"67909-49-3",{"v":19,"d":"19.00"},63.05,"N/A","N/A","http://selleckchem.com/products/dehydroevodiamine.html","C19H15N3O","inner salt","DHED","C[N+]1=C2N(CCC3=C2[N-]C4=C3C=CC=C4)C(=O)C5=C1C=CC=C5",3.186,1,0,0]
["S3818","Tectoridin","d5","L6400-03","in 10mM DMSO","Others","Others","Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.",{"v":462.4,"d":"462.40"},"611-40-5",{"v":92,"d":"92.00"},198.96,"N/A","N/A","http://selleckchem.com/products/tectoridin.html","C22H22O11","free base","Shekanin","COC1=C(O)C2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1OC4OC(CO)C(O)C(O)C4O",0.194,5,6,5]
["S3820","Dehydroevodiamine hydrochloride","e5","L6400-03","in 10mM DMSO","AChR","Neuronal Signaling","Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.",{"v":337.8,"d":"337.80"},"111664-82-5",{"v":37,"d":"37.00"},109.53,"N/A","N/A","http://selleckchem.com/products/dehydroevodiamine-hydrochloride.html","C19H15N3O.HCl","hydrochloride","N/A","Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13",2.891,2,0,0]
["S3822","Schisandrin A","f5","L6400-03","in 10mM DMSO","AdipoR","Metabolism","Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.",416.51,"61281-38-7",{"v":83,"d":"83.00"},199.27,"N/A","N/A","http://selleckchem.com/products/schisandrin-a.html","C24H32O6","free base","Deoxyschizandrin, Wuweizisu A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C(OC)C(=C3OC)OC",5.266,6,0,6]
["S3824","Quercitrin","g5","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.",448.38,"522-12-3",{"v":89,"d":"89.00"},198.49,"N/A","N/A","http://selleckchem.com/products/quercitrin.html","C21H20O11","free base","3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine","CC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.589,4,7,3]
["S3826","Hydroxytyrosol","h5","L6400-03","in 10mM DMSO","Others","Others","Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities.",154.16,"10597-60-1",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol.html","C8H10O3","free base","3-Hydroxytyrosol; 3,4-dihydroxyphenylethanol; Dihydroxyphenylethanol; 2-(3,4-Di-hydroxyphenyl)-ethanol","OCCC1=CC=C(O)C(=C1)O",1.062,0,3,2]
["S3828","Orcinol glucoside","a6","L6400-03","in 10mM DMSO","Others","Others","Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects.",286.28,"21082-33-7",{"v":58,"d":"58.00"},{"v":202.6,"d":"202.60"},"N/A","N/A","http://selleckchem.com/products/orcinol-glucoside.html","C13H18O7","free base","Sakakin","CC1=CC(=CC(=C1)OC2OC(CO)C(O)C(O)C2O)O",-0.098,2,5,3]
["S3833","Amentoflavone","b6","L6400-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.",538.46,"1617-53-4",{"v":100,"d":"100.00"},185.71,"N/A","N/A","http://selleckchem.com/products/amentoflavone.html","C30H18O10","free base","Didemethyl Ginkgetin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(O)C=C3O)C4=CC(=CC=C4O)C5=CC(=O)C6=C(O5)C=C(O)C=C6O",4.509,4,6,3]
["S3834","Astaxanthin","c6","L6400-03","in 10mM DMSO","PPAR","Metabolism","Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.",596.84,"472-61-7",{"v":100,"d":"100.00"},167.55,"N/A","N/A","http://selleckchem.com/products/astaxanthin.html","C40H52O4","free base","β-Carotene-4,4'-dione, Trans-Astaxanthin","CC(=C\\C=C\\C=C(C)\\C=C\\C=C(C)\\C=C\\C1=C(C)C(=O)C(O)CC1(C)C)/C=C/C=C(C)/C=C/C2=C(C)C(=O)C(O)CC2(C)C",8.421,2,2,10]
["S3835","Loganin","d6","L6400-03","in 10mM DMSO","AChR,BACE,BChE","Neuronal Signaling","Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.",390.38,"18524-94-2",{"v":78,"d":"78.00"},199.81,"N/A","N/A","http://selleckchem.com/products/loganin.html","C17H26O10","free base","Loganoside","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)C(O)CC13",-1.895,5,5,5]
["S3836","6-Gingerol","e6","L6400-03","in 10mM DMSO","Apoptosis related","Apoptosis","6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.",294.39,"23513-14-6",{"v":58,"d":"58.00"},197.02,"N/A","N/A","http://selleckchem.com/products/6-gingerol.html","C17H26O4","free base","N/A","CCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",3.638,2,2,10]
["S3837","Echinocystic acid","f6","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.",{"v":472.7,"d":"472.70"},"510-30-5",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/echinocystic-acid.html","C30H48O4","free base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",5.345,1,2,1]
["S3838","Carnosic acid","g6","L6400-03","in 10mM DMSO","ROS","Immunology & Inflammation","Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.",332.43,"3650-09-7",{"v":66,"d":"66.00"},198.54,"N/A","N/A","http://selleckchem.com/products/carnosic-acid.html","C20H28O4","free base","Salvin","CC(C)C1=CC2=C(C(=C1O)O)C3(CCCC(C)(C)C3CC2)C(O)=O",4.905,1,2,2]
["S3839","1-Deoxynojirimycin","h6","L6400-03","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.",163.17,"19130-96-2",{"v":16,"d":"16.00"},98.06,"N/A","N/A","http://selleckchem.com/products/1-deoxynojirimycin.html","C6H13NO4","free base","duvoglustat, moranolin","OCC1NCC(O)C(O)C1O",{"v":-2.44,"d":"-2.440"},0,5,1]
["S3840","Baohuoside I","a7","L6400-03","in 10mM DMSO","ROS","Immunology & Inflammation","Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.",514.52,"113558-15-9",{"v":100,"d":"100.00"},194.36,"N/A","N/A","http://selleckchem.com/products/baohuoside-i.html","C27H30O10","Flavonoid glycoside","Icariside II","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O)C=C(O)C(=C4O2)CC=C(C)C",2.913,5,5,6]
["S3842","Isoquercitrin","b7","L6400-03","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.",464.38,"482-35-9",{"v":92,"d":"92.00"},198.11,"N/A","N/A","http://selleckchem.com/products/isoquercitrin.html","C21H20O12","free base","Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside","OCC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S3843","Madecassoside","c7","L6400-03","in 10mM DMSO","Others","Others","Madecassoside (Asiaticoside A) is the main active triterpene constituent of Centella asiatica herbs, a traditional Chinese medicine for wound healing and scar management.",975.12,"34540-22-2",{"v":100,"d":"100.00"},102.55,{"v":100,"d":"100.00"},102.55,"http://selleckchem.com/products/madecassoside.html","C48H78O20","free base","Asiaticoside A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O",{"v":-1.27,"d":"-1.270"},7,13,10]
["S3846","Eupatilin","d7","L6400-03","in 10mM DMSO","PPAR","Metabolism","Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.",344.32,"22368-21-4",{"v":68,"d":"68.00"},197.49,"N/A","N/A","http://selleckchem.com/products/eupatilin.html","C18H16O7","free base","NSC 122413","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)OC",2.603,5,2,4]
["S3848","Hydroxytyrosol Acetate","e7","L6400-03","in 10mM DMSO","Others","Others","Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.",{"v":196.2,"d":"196.20"},"69039-02-7",{"v":39,"d":"39.00"},198.78,"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol-acetate.html","C10H12O4","free base","HTy-Ac","CC(=O)OCCC1=CC(=C(O)C=C1)O",1.441,2,2,4]
["S3849","D-Galactose","f7","L6400-03","in 10mM DMSO","Others","Others","D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.",180.16,"59-23-4",{"v":36,"d":"36.00"},199.82,"N/A","N/A","http://selleckchem.com/products/d-galactose.html","C6H12O6","free base","D-Galactopyranose, D-(+)-Galactose","OCC1OC(O)C(O)C(O)C1O",-2.514,1,4,1]
["S3850","Glucosamine sulfate","g7","L6400-03","in 10mM DMSO","Others","Others","Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.",277.25,"29031-19-4",{"v":4,"d":"4.00"},14.43,{"v":55,"d":"55.00"},198.38,"http://selleckchem.com/products/glucosamine-sulfate.html","C6H13NO5.H2SO4","sulfate","D-Glucosaminesulfate, D-Glucosamine sulphate","NC(C=O)C(O)C(O)C(O)CO.O[S](O)(=O)=O",-3.688,1,5,5]
["S3855","Ethyl ferulate","h7","L6400-03","in 10mM DMSO","Others","Others","Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.",222.24,"4046-02-0",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/ethyl-ferulate.html","C12H14O4","free base","Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate","CCOC(=O)/C=C/C1=CC(=C(O)C=C1)OC",2.243,3,1,5]
["S3857","4-Hydroxybenzyl alcohol","a8","L6400-03","in 10mM DMSO","Apoptosis related","Apoptosis","4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.",124.14,"623-05-2",{"v":24,"d":"24.00"},193.33,"N/A","N/A","http://selleckchem.com/products/4-hydroxybenzyl-alcohol.html","C7H8O2","free base","P-Methylolphenol, 4-Methylolphenol","OCC1=CC=C(O)C=C1",0.983,0,2,1]
["S3859","Vanillyl Alcohol","b8","L6400-03","in 10mM DMSO","Others","Others","Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food.",154.16,"498-00-0",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/vanillyl-alcohol.html","C8H10O3","free base","4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol, 4-Hydroxy-3-methoxybenzenemethanol","COC1=CC(=CC=C1O)CO",0.967,1,2,2]
["S3860","Allicin","c8","L6400-03","in 10mM DMSO","Fungal","Metabolism","Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.",162.27,"539-86-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/allicin.html","C6H10OS2","free base","diallyl thiosulfinate","C=CCS[S](=O)CC=C",2.005,1,0,5]
["S3862","Gallic acid trimethyl ether","d8","L6400-03","in 10mM DMSO","Others","Others","Gallic acid trimethyl ether (Eudesmic acid, Tri-O-methylgallic acid, Benzoic acid, 3,4,5-Trimethoxybenzoic acid) is an O-methylated trihydroxybenzoic acid that is found in olive.",{"v":212.2,"d":"212.20"},"118-41-2",{"v":42,"d":"42.00"},197.93,"N/A","N/A","http://selleckchem.com/products/gallic-acid-trimethyl-ether.html","C10H12O5","free base","Eudesmic acid, Tri-O-methylgallic acid, Benzoic acid, 3,4,5-Trimethoxybenzoic acid","COC1=CC(=CC(=C1OC)OC)C(O)=O",{"v":1.41,"d":"1.410"},4,0,4]
["S3869","Methyl protocatechuate","e8","L6400-03","in 10mM DMSO","Others","Others","Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.",168.15,"2150-43-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/methyl-protocatechuate.html","C8H8O4","free base","Methyl 3,4-dihydroxybenzoate; 3,4-Dihydroxybenzoic acid methyl ester; Protocatechuic Acid Methyl Ester","COC(=O)C1=CC(=C(O)C=C1)O",1.201,2,2,2]
["S3870","D-Pinitol","f8","L6400-03","in 10mM DMSO","Influenza Virus","Microbiology","D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.",194.18,"10284-63-6",{"v":38,"d":"38.00"},195.69,"N/A","N/A","http://selleckchem.com/products/d-pinitol.html","C7H14O6","free base","Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol","COC1C(O)C(O)C(O)C(O)C1O",-2.656,1,5,1]
["S3881","Scopoletin","g8","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.",192.17,"92-61-5",{"v":38,"d":"38.00"},197.74,"N/A","N/A","http://selleckchem.com/products/scopoletin.html","C10H8O4","free base","Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid","COC1=CC2=C(OC(=O)C=C2)C=C1O",1.641,3,1,1]
["S3883","Protopine","h8","L6400-03","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.",353.37,"130-86-9",{"v":30,"d":"30.00"},{"v":84.9,"d":"84.90"},"N/A","N/A","http://selleckchem.com/products/protopine.html","C20H19NO5","free base","Corydinine, Fumarine, Biflorine, Macleyine","CN1CCC2=C(C=C3OCOC3=C2)C(=O)CC4=C(C1)C5=C(OCO5)C=C4",2.953,5,0,0]
["S3884","Jatrorrhizine","a9","L6400-03","in 10mM DMSO","AChR","Neuronal Signaling","Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.",338.38,"3621-38-3",{"v":67,"d":"67.00"},{"v":198,"d":"198.00"},"N/A","N/A","http://selleckchem.com/products/jatrorrhizine.html","C20H20NO4","free base","Neprotin, Yatrorizine","COC1=CC2=C(CC[N+]3=CC4=C(C=CC(=C4OC)OC)C=C23)C=C1O",3.936,3,1,3]
["S3885","Pyrogallol","b9","L6400-03","in 10mM DMSO","ROS","Immunology & Inflammation","Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.",126.11,"87-66-1",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/pyrogallol.html","C6H6O3","free base","1,2,3-trihydroxybenzene","OC1=C(O)C(=CC=C1)O",1.103,0,3,0]
["S3888","3,4',5-Trimethoxy-trans-stilbene","c9","L6400-03","in 10mM DMSO","p38 MAPK","Apoptosis","3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.",270.32,"22255-22-7",{"v":54,"d":"54.00"},199.76,"N/A","N/A","http://selleckchem.com/products/3-4-5-trimethoxy-trans-stilbene.html","C17H18O3","free base","MR-3","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC",3.766,3,0,5]
["S3899","Hederagenin","d9","L6400-03","in 10mM DMSO","COX,NF-κB,NOS","Immunology & Inflammation","Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB.",{"v":472.7,"d":"472.70"},"465-99-6",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hederagenin.html","C30H48O4","free base","Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1)C(O)=O",5.356,1,2,2]
["S3905","Iso-Steviol","e9","L6400-03","in 10mM DMSO","Others","Others","Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects.",318.45,"27975-19-5",{"v":63,"d":"63.00"},197.83,"N/A","N/A","http://selleckchem.com/products/iso-steviol.html","C20H30O3","free base","N/A","CC12CCC3C4(C)CCCC(C)(C4CCC3(CC1=O)C2)C(O)=O",3.924,2,0,1]
["S3906","Astragalus polyphenols","f9","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.",406.38,"82373-94-2",{"v":81,"d":"81.00"},199.32,"N/A","N/A","http://selleckchem.com/products/astragalus-polyphenols.html","C20H22O9","free base","N/A","OCC1OC(OC2=C(\\C=C\\C3=CC=C(O)C=C3)C=C(O)C=C2O)C(O)C(O)C1O",0.918,2,7,5]
["S3909","Catalpol","g9","L6400-03","in 10mM DMSO","Others","Others","Catalpol (Catalpinoside, Digitalis purpurea L), an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models.",362.33,"2415-24-9",{"v":72,"d":"72.00"},198.71,"N/A","N/A","http://selleckchem.com/products/catalpol.html","C15H22O10","free base","Catalpinoside, Digitalis purpurea L","OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O",-3.581,4,6,4]
["S3917","Tetrahydrocurcumin","h9","L6400-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties.  Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.",372.41,"36062-04-1",{"v":74,"d":"74.00"},{"v":198.7,"d":"198.70"},"<1","N/A","https://www.selleckchem.com/products/tetrahydrocurcumin.html","C21H24O6","free base","Tetrahydrodiferuloylmethane, Tetrahydro Curcumin","COC1=C(O)C=CC(=C1)CCC(=O)CC(=O)CCC2=CC=C(O)C(=C2)OC",-0.415,9,13,12]
["S3924","Ginsenoside Rb1","a10","L6400-03","in 10mM DMSO","ATPase,IFN,IRAK,NF-κB,NOS,TLR,TNF-alpha","Transmembrane Transporters","Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.",1109.29,"41753-43-9",{"v":100,"d":"100.00"},90.15,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rb1.html","C54H92O23","free base","Gypenoside Ⅲ","CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-1.198,8,15,16]
["S3925","(-)-Epicatechin gallate","b10","L6400-03","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,"N/A","N/A","http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3926","Forsythin","c10","L6400-03","in 10mM DMSO","PDE","GPCR & G Protein","Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties.",534.55,"487-41-2",{"v":100,"d":"100.00"},187.07,"N/A","N/A","http://selleckchem.com/products/forsythin.html","C27H34O11","free base","Phillyrin","COC1=CC=C(C=C1OC)C2OCC3C2COC3C4=CC(=C(OC5OC(CO)C(O)C(O)C5O)C=C4)OC",0.479,7,4,8]
["S3930","Liquiritin","d10","L6400-03","in 10mM DMSO","AKR1C","Immunology & Inflammation","Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.",418.39,"551-15-5",{"v":100,"d":"100.00"},239.01,"N/A","N/A","http://selleckchem.com/products/liquiritin.html","C21H22O9","free base","Liquiritoside, Liquiritigenin-4'-O-glucoside","OCC1OC(OC2=CC=C(C=C2)C3CC(=O)C4=C(O3)C=C(O)C=C4)C(O)C(O)C1O",0.686,4,5,4]
["S3932","Astilbin","e10","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.",450.39,"29838-67-3",{"v":100,"d":"100.00"},222.03,"N/A","N/A","http://selleckchem.com/products/astilbin.html","C21H22O11","free base","Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside","CC1OC(OC2C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.621,4,7,3]
["S3934","Acetyl Resveratrol","f10","L6400-03","in 10mM DMSO","Others","Others","Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.",354.35,"42206-94-0",{"v":70,"d":"70.00"},197.54,"<1","N/A","https://www.selleckchem.com/products/acetyl-resveratrol.html","C20H18O6","free base","N/A","CC(=O)OC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC(C)=O)OC(C)=O",3.119,6,0,8]
["S3937","Pterostilbene","g10","L6400-03","in 10mM DMSO","Others","Others","Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.",{"v":256.3,"d":"256.30"},"537-42-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/pterostilbene.html","C16H16O3","free base","N/A","COC1=CC(=CC(=C1)\\C=C\\C2=CC=C(O)C=C2)OC",3.541,2,1,4]
["S3941","Pinocembrin","h10","L6400-03","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.",256.25,"480-39-7",{"v":51,"d":"51.00"},199.02,"<1","N/A","http://selleckchem.com/products/pinocembrin.html","C15H12O4","free base","Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone","OC1=CC2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O",2.615,2,2,1]
["S3952","3,4-Dihydroxybenzaldehyde","a11","L6400-03","in 10mM DMSO","Others","Others","3,4-Dihydroxybenzaldehyde (Protocatechuic aldehyde) is a phenolic aldehyde, a precursor in vanillin synthesis via biotransformation by cell cultures of Capsicum frutescens, a type of chili pepper.",138.12,"139-85-5",{"v":27,"d":"27.00"},195.48,"N/A","N/A","http://selleckchem.com/products/3-4-dihydroxybenzaldehyde.html","C7H6O3","free base","protocatechuic aldehyde","OC1=CC=C(C=O)C=C1O",1.105,1,2,1]
["S3956","Tetramethylpyrazine","b11","L6400-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.",136.19,"1124-11-4",{"v":27,"d":"27.00"},198.25,"N/A","N/A","http://selleckchem.com/products/tetramethylpyrazine.html","C8H12N2","free base","ligustrazine","CC1=NC(=C(C)N=C1C)C",0.659,2,0,0]
["S3957","Gamma-Oryzanol","c11","L6400-03","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.  γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).",602.89,"11042-64-1",{"v":100,"d":"100.00"},165.87,"N/A","N/A","http://selleckchem.com/products/gamma-oryzanol.html","C40H58O4","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2CCC34CC35CCC6(C)C(CCC6(C)C5CCC4C2(C)C)C(C)CCC=C(C)C",9.806,3,1,9]
["S3967","Flavone","d11","L6400-03","in 10mM DMSO","Apoptosis related","Apoptosis","Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.",222.24,"525-82-6",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/flavone.html","C15H10O2","free base","2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron","O=C1C=C(OC2=C1C=CC=C2)C3=CC=CC=C3",3.136,2,0,1]
["S3968","Histamine","e11","L6400-03","in 10mM DMSO","Histamine Receptor","Immunology & Inflammation","Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist.",111.15,"51-45-6",{"v":22,"d":"22.00"},197.93,"N/A","N/A","http://selleckchem.com/products/histamine.html","C5H9N3","free base","N/A","NCCC1=C[NH]C=N1",-0.714,1,2,2]
["S3969","Veratric acid","f11","L6400-03","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,PGES","Immunology & Inflammation","Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.",182.17,"93-07-2",{"v":36,"d":"36.00"},197.62,"N/A","N/A","http://selleckchem.com/products/veratric-acid.html","C9H10O4","free base","3,4-Dimethoxybenzoic acid","COC1=C(OC)C=C(C=C1)C(O)=O",1.426,3,0,3]
["S3974","(+)-Catechin hydrate","g11","L6400-03","in 10mM DMSO","COX","Immunology & Inflammation","(+)-Catechin hydrate is a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.  (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.",290.27,"225937-10-0",{"v":58,"d":"58.00"},199.81,"N/A","N/A","http://selleckchem.com/products/catechin-hydrate.html","C15H14O6.xH2O","hydrate","N/A","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S3975","Protocatechuic acid","h11","L6400-03","in 10mM DMSO","Apoptosis related","Apoptosis","Protocatechuic acid (PCA, 3,4-Dihydroxybenzoic acid, Protocatechuate), a dihydroxybenzoic acid, is a type of widely distributed naturally occurring phenolic acid.",154.12,"99-50-3",{"v":30,"d":"30.00"},194.65,"N/A","N/A","http://selleckchem.com/products/protocatechuic-acid.html","C7H6O4","free base","3,4-Dihydroxybenzoic acid, Protocatechuate","OC(=O)C1=CC(=C(O)C=C1)O",0.975,1,2,1]
["S3980","Pyridoxine","a2","L6400-04","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.",169.18,"65-23-6",{"v":33,"d":"33.00"},195.06,"N/A","N/A","http://selleckchem.com/products/pyridoxine.html","C8H11NO3","free base","Pyridoxol, Vitamin B6, Gravidox","CC1=NC=C(CO)C(=C1O)CO",{"v":-0.49,"d":"-0.490"},1,3,2]
["S3981","Sinapinic Acid","b2","L6400-04","in 10mM DMSO","ACE,HDAC","DNA Damage/DNA Repair","Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.",224.21,"530-59-6",{"v":44,"d":"44.00"},196.24,"<1","N/A","http://selleckchem.com/products/sinapinic-acid.html","C11H12O5","free base","Sinapic acid","COC1=C(O)C(=CC(=C1)\\C=C\\C(O)=O)OC",1.652,3,1,4]
["S3984","Nordihydroguaiaretic acid (NDGA)","c2","L6400-04","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase","Metabolism","Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.",302.36,"500-38-9",{"v":60,"d":"60.00"},198.44,"<1","N/A","http://selleckchem.com/products/nordihydroguaiaretic-acid.html","C18H22O4","free base","N/A","CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O",4.708,0,4,5]
["S3993","Ethyl Vanillate","d2","L6400-04","in 10mM DMSO","Dehydrogenase","Metabolism","Ethyl vanillin (Bourbonal, Ethylprotal), a vanillin analog, is a flavouring agent and a fungicidal agent that exhibits strong antioxidant activity. Ethyl Vanillate inhibits 17β-HSD2 with an IC50 1.3 µM.",{"v":196.2,"d":"196.20"},"617-05-0",{"v":39,"d":"39.00"},198.78,"N/A","N/A","http://selleckchem.com/products/ethylvanillate.html","C10H12O4","free base","Bourbonal, Ethylprotal","CCOC(=O)C1=CC(=C(O)C=C1)OC",1.775,3,1,4]
["S3996","Thioctic acid","e2","L6400-04","in 10mM DMSO","Others","Others","Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form., Thioctic acid (DL-α-Lipoic acid)是环状二硫抗氧化剂，可与其还原性二硫酚形式相互转换。",206.33,"1077-28-7",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/thioctic-acid.html","C8H14O2S2","free base","DL-α-Lipoic Acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S3998","(+)-α-Lipoic acid","f2","L6400-04","in 10mM DMSO","LTR,NF-κB","NF-κB","(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.",206.33,"1200-22-2",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/alpha-lipoic-acid.html","C8H14O2S2","free base","(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S4002","Sitagliptin phosphate monohydrate","g2","L6400-04","in 10mM DMSO","DPP","Metabolism","Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.",523.32,"654671-77-9",{"v":100,"d":"100.00"},191.09,{"v":41,"d":"41.00"},78.35,"https://www.selleckchem.com/products/sitagliptin-phosphate-monohydrate.html","C16H15F6N5O.H3PO4.H2O","phosphate &monohydrate","MK-0431","O.NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F.O[P](O)(O)=O",1.254,3,1,5]
["S4017","Allylthiourea","h2","L6400-04","in 10mM DMSO","ROS","Immunology & Inflammation","Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.",116.18,"109-57-9",{"v":23,"d":"23.00"},197.97,"<1","N/A","http://selleckchem.com/products/allylthiourea.html","C4H8N2S","free base","N/A","NC(=S)NCC=C",0.842,0,2,3]
["S4073","Sodium 4-Aminosalicylate","a3","L6400-04","in 10mM DMSO","NF-κB","NF-κB","Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.",211.15,"6018-19-5",{"v":42,"d":"42.00"},198.91,{"v":42,"d":"42.00"},198.91,"http://selleckchem.com/products/aminosalicylate-sodium.html","C7H7NO3.2H2O.Na","Sodium Salt","N/A","[Na+].NC1=CC(=C(C=C1)C([O-])=O)O",-1.003,0,2,1]
["S4084","Lomerizine 2HCl","b3","L6400-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.",541.46,"101477-54-7",{"v":100,"d":"100.00"},184.69,"<1","N/A","http://selleckchem.com/products/lomerizine-hcl.html","C27H30F2N2O3.2HCl","Dihydrochloride","KB-2796","Cl.Cl.COC1=C(OC)C(=C(CN2CCN(CC2)C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C=C1)OC",6.182,3,0,8]
["S4101","Voglibose","c3","L6400-04","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.",267.28,"83480-29-9",{"v":74,"d":"74.00"},276.86,{"v":74,"d":"74.00"},276.86,"http://selleckchem.com/products/voglibose.html","C10H21NO7","free base","AO 128","OCC(CO)NC1CC(O)(CO)C(O)C(O)C1O",-4.083,0,7,5]
["S4118","Histamine 2HCl","d3","L6400-04","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Histamine(Ceplene) is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.",184.07,"56-92-8",{"v":3,"d":"3.00"},{"v":16.3,"d":"16.30"},{"v":37,"d":"37.00"},201.01,"http://selleckchem.com/products/histamine-2hcl.html","C5H9N3.2HCl","Dihydrochloride","Ceplene","Cl.Cl.NCCC1=C[NH]C=N1",{"v":0.05,"d":"0.050"},1,2,2]
["S4128","Troxipide","e3","L6400-04","in 10mM DMSO","Others","Others","Troxipide(KU 54) is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum.",294.35,"30751-05-4",{"v":18,"d":"18.00"},61.15,"<1","N/A","http://selleckchem.com/products/troxipide.html","C15H22N2O4","free base","KU 54","COC1=C(OC)C(=CC(=C1)C(=O)NC2CCCNC2)OC",1.081,4,2,5]
["S4132","Deoxyarbutin","f3","L6400-04","in 10mM DMSO","Tyrosinase","Proteases","DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.",194.23,"53936-56-4",{"v":39,"d":"39.00"},200.79,"<1","N/A","http://selleckchem.com/products/deoxyarbutin.html","C11H14O3","free base","D-arbutin,D-Arb","OC1=CC=C(OC2CCCCO2)C=C1",2.298,2,1,2]
["S4188","Sasapyrine","g3","L6400-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.",258.23,"552-94-3",{"v":52,"d":"52.00"},201.37,"<1","N/A","http://selleckchem.com/products/sasapyrine.html","C14H10O5","free base","NSC-49171,Salsalate","OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O",2.649,3,1,4]
["S4198","Aminothiazole","h3","L6400-04","in 10mM DMSO","Bacterial","Microbiology","Aminothiazole(2-Aminothiazole,2-Thiazolylamine) can be used as a thyroid inhibitor and it has antibacterial activity.",100.14,"96-50-4",{"v":20,"d":"20.00"},199.72,{"v":20,"d":"20.00"},199.72,"http://selleckchem.com/products/aminothiazole.html","C3H4N2S","free base","2-Aminothiazole,2-Thiazolylamine","NC1=NC=CS1",{"v":0.08,"d":"0.080"},1,1,0]
["S4206","Cysteamine HCl","a4","L6400-04","in 10mM DMSO","Antioxidant","Metabolism","Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.",113.61,"156-57-0",{"v":23,"d":"23.00"},202.45,{"v":23,"d":"23.00"},202.45,"http://selleckchem.com/products/cysteamine-hcl.html","C2H7NS.HCl","Hydrochloride","Mercaptamine","Cl.NCCS",0.166,0,1,1]
["S4223","Mevastatin","b4","L6400-04","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.",390.51,"73573-88-3",{"v":78,"d":"78.00"},199.74,"<1","N/A","http://selleckchem.com/products/mevastatin.html","C23H34O5","free base","ML-236B,Compactin","CCC(C)C(=O)OC1CCC=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",3.966,4,1,7]
["S4238","Cepharanthine","c4","L6400-04","in 10mM DMSO","TNF-alpha","Apoptosis","Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.",606.71,"481-49-2",{"v":100,"d":"100.00"},164.82,"<1","N/A","http://selleckchem.com/products/cepharanthine.html","C37H38N2O6","free base","NSC-623442","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C(=C6OCOC6=C5)OC7=C(OC)C=C8CCN(C)C(CC(=C2)C=C1)C8=C7)C=C3",7.019,6,0,2]
["S4261","EUK 134","d4","L6400-04","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.",416.74,"81065-76-1",{"v":83,"d":"83.00"},199.16,{"v":13,"d":"13.00"},31.19,"http://selleckchem.com/products/euk-134.html","C18H18ClMnN2O4","Complex","N/A","COC1=C2O[Mn]|3|4(Cl)OC5=C(OC)C=CC=C5C=N|3CCN|4=CC2=CC=C1",3.526,4,0,2]
["S4263","Efaproxiral Sodium","e4","L6400-04","in 10mM DMSO","ROS","Immunology & Inflammation","Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. Efaproxiral Sodium is used for brain metastases originating from breast cancer.",363.38,"170787-99-2",{"v":73,"d":"73.00"},200.89,{"v":73,"d":"73.00"},200.89,"http://selleckchem.com/products/efaproxiral-sodium.html","C20H23NO4.Na","Sodium salt","RSR13 Sodium","[Na+].CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(OC(C)(C)C([O-])=O)C=C2)C",2.408,2,1,6]
["S4265","Nicaraven","f4","L6400-04","in 10mM DMSO","Others","Others","Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.",284.31,"79455-30-4",{"v":57,"d":"57.00"},200.49,{"v":57,"d":"57.00"},200.49,"http://selleckchem.com/products/nicaraven.html","C15H16N4O2","free base","N/A","CC(CNC(=O)C1=CN=CC=C1)NC(=O)C2=CN=CC=C2",-0.029,4,2,5]
["S4357","Tacrine HCl","g4","L6400-04","in 10mM DMSO","AChR","Neuronal Signaling","Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.",234.72,"1684-40-8",{"v":46,"d":"46.00"},195.98,{"v":46,"d":"46.00"},195.98,"http://www.selleckchem.com/products/tacrine-hcl.html","C13H14N2.HCl","hydrochlorid","N/A","Cl.NC1=C2C=CC=CC2=NC3=C1CCCC3",3.172,1,1,0]
["S4511","6-Benzylaminopurine","h4","L6400-04","in 10mM DMSO","ROS","Immunology & Inflammation","6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.",225.25,"1214-39-7",{"v":45,"d":"45.00"},199.78,"<1","N/A","http://selleckchem.com/products/6-benzylaminopurine.html","C12H11N5","free base","N/A","C(NC1=NC=NC2=C1[NH]C=N2)C3=CC=CC=C3",1.693,3,2,3]
["S4539","Salicylic acid","a5","L6400-04","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1","N/A","http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4561","Danthron","b5","L6400-04","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.",240.21,"117-10-2",{"v":4,"d":"4.00"},16.65,"<1","N/A","http://selleckchem.com/products/danthron.html","C14H8O4","free base","chrysazin, Antrapurol","OC1=CC=CC2=C1C(=O)C3=C(O)C=CC=C3C2=O",2.324,2,2,0]
["S4603","Gallic acid","c5","L6400-04","in 10mM DMSO","ROS","Immunology & Inflammation","Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.",170.12,"149-91-7",{"v":34,"d":"34.00"},199.86,{"v":7,"d":"7.00"},41.15,"http://selleckchem.com/products/gallic-acid.html","C7H6O5","free base","3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid","OC(=O)C1=CC(=C(O)C(=C1)O)O",0.733,1,3,1]
["S4612","Dapson","d5","L6400-04","in 10mM DMSO","Antibiotics","Microbiology","Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.",{"v":248.3,"d":"248.30"},"80-08-0",{"v":49,"d":"49.00"},197.34,"<1","N/A","http://selleckchem.com/products/dapson.html","C12H12N2O2S","free base","Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS","NC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(N)C=C2",1.439,2,2,2]
["S4636","Teneligliptin hydrobromide","e5","L6400-04","in 10mM DMSO","DPP","Proteases","Teneligliptin (Teneligliptin hydrobromide anhydrous) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.",628.86,"906093-29-6",{"v":100,"d":"100.00"},159.02,{"v":100,"d":"100.00"},159.02,"http://selleckchem.com/products/teneligliptin-hydrobromide.html","C22H30N6OS.5/2HBr","hydrobromide","Teneligliptin hydrobromide anhydrous","CC1=N[N](C2=CC=CC=C2)C(=C1)N3CCN(CC3)C4CNC(C4)C(=O)N5CCSC5",2.645,2,1,4]
["S4648","Dantrolene sodium hemiheptahydrate","f5","L6400-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.",399.29,"24868-20-0",{"v":14,"d":"14.00"},35.06,"<1","N/A","https://www.selleckchem.com/products/dantrolene-sodium-s4648.html","C14H9N4O5.7/2H2O.Na","Sodium salt hemiheptahydrate","Dantrolene sodium salt, Dantrium, Sodium dantrolene","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4667","Lidocaine hydrochloride","g5","L6400-04","in 10mM DMSO","EGFR","Angiogenesis","Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.",{"v":270.8,"d":"270.80"},"73-78-9",{"v":54,"d":"54.00"},199.41,{"v":54,"d":"54.00"},199.41,"http://selleckchem.com/products/lidocaine-hydrochloride.html","C14H22N2O.HCl","hydrochloride","Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural","Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",3.008,1,1,5]
["S4676","Gluconolactone","h5","L6400-04","in 10mM DMSO","Others","Others","Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.",178.14,"90-80-2",{"v":35,"d":"35.00"},196.47,{"v":35,"d":"35.00"},196.47,"http://www.selleckchem.com/products/gluconolactone.html","C6H10O6","Free Base","N/A","OCC1OC(=O)C(O)C(O)C1O",-2.229,2,4,1]
["S4683","Sildenafil Mesylate","a6","L6400-04","in 10mM DMSO","PDE","Metabolism","Sildenafil Mesylate(UK-92480 Mesylate) is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.","474.58(free base)","1308285-21-3",{"v":100,"d":"100.00"},{"v":211,"d":"211.00"},{"v":100,"d":"100.00"},"N/A","http://selleckchem.com/products/sildenafil-mesylate.html","C22H30N6O4S.xCH4O3S","Mesylate","UK-92480 Mesylate","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.C[S](O)(=O)=O",1.833,6,1,7]
["S4686","Vitamin E","b6","L6400-04","in 10mM DMSO","COX,VEGFR","Neuronal Signaling","Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.",430.71,"59-02-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e.html","C29H50O2","free base","Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S4697","Saxagliptin hydrate","c6","L6400-04","in 10mM DMSO","DPP","Proteases","Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",333.43,"945667-22-1",{"v":66,"d":"66.00"},197.94,{"v":1,"d":"1.00"},{"v":3,"d":"3.00"},"http://selleckchem.com/products/saxagliptin-hydrate.html","C18H25N3O2.H2O","hydrate","BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate","O.NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.068,1,1,2]
["S4701","2-Deoxy-D-glucose (2-DG)","d6","L6400-04","in 10mM DMSO","Apoptosis related,Carbohydrate Metabolism,HSV","Metabolism","2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.",164.16,"154-17-6",{"v":32,"d":"32.00"},194.93,{"v":32,"d":"32.00"},194.93,"http://selleckchem.com/products/2-deoxy-d-glucose.html","C6H12O5","free base","2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose","OCC1OC(O)CC(O)C1O",-1.748,1,3,1]
["S4706","Eugenol","e6","L6400-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.",{"v":164.2,"d":"164.20"},"97-53-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/eugenol.html","C10H12O2","Free Base","4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol","COC1=C(O)C=CC(=C1)CC=C",2.579,1,1,3]
["S4712","Diethylmaleate","f6","L6400-04","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Diethylmaleate (Diethyl ester, Maleic acid diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.",172.18,"141-05-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/diethylmaleate.html","C8H12O4","Free Base","Diethyl ester, Maleic acid diethyl ester","CCOC(=O)\\C=C/C(=O)OCC",1.187,4,0,6]
["S4722","(+)-Catechin","g6","L6400-04","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,",290.27,"154-23-4",{"v":58,"d":"58.00"},199.81,{"v":58,"d":"58.00"},199.81,"http://selleckchem.com/products/catechin.html","C15H14O6","free base","Cianidanol, Catechinic acid, Catechuic acid, Catechin","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4723","(-)Epicatechin","h6","L6400-04","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(−)Epicatechin (L-Epicatechin, (-)-Epicatechol) is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.",290.27,"490-46-0",{"v":58,"d":"58.00"},199.81,"<1","N/A","http://selleckchem.com/products/-epicatechin.html","C15H14O6","free base","L-Epicatechin, (-)-Epicatechol","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4731","Perphenazine","a7","L6400-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.",403.97,"58-39-9",{"v":74,"d":"74.00"},183.18,"<1","N/A","http://selleckchem.com/products/perphenazine.html","C21H26ClN3OS","free base","Perphenazin, Trilafon, Etaperazine","OCCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4)CC1",4.157,0,1,6]
["S4732","MPTP hydrochloride","b7","L6400-04","in 10mM DMSO","Apoptosis related,Dopamine Receptor","Neuronal Signaling","MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.",209.72,"23007-85-4",{"v":20,"d":"20.00"},95.37,{"v":41,"d":"41.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/mptp-hydrochloride.html","C12H15N.HCl","hydrochloride","N/A","Cl.CN1CCC(=CC1)C2=CC=CC=C2",2.788,0,0,1]
["S4735","Salvianolic acid B","c7","L6400-04","in 10mM DMSO","Sirtuin","Epigenetics","Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.",718.61,"121521-90-2",{"v":100,"d":"100.00"},139.16,{"v":100,"d":"100.00"},139.16,"http://selleckchem.com/products/salvianolic-acid-b.html","C36H30O16","free base","Sal B, Lithospermate B, Lithospermic acid B","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=CC=C(O)C3=C2C(C(O3)C4=CC=C(O)C(=C4)O)C(=O)OC(CC5=CC=C(O)C(=C5)O)C(O)=O",4.718,7,7,14]
["S4739","Oxyresveratrol","d7","L6400-04","in 10mM DMSO","Tyrosinase","Proteases","Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.",244.24,"29700-22-9",{"v":48,"d":"48.00"},196.53,{"v":1,"d":"1.00"},4.09,"http://selleckchem.com/products/oxyresveratrol.html","C14H12O4","free base","Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene","OC1=CC=C(\\C=C\\C2=CC(=CC(=C2)O)O)C(=C1)O",2.848,0,4,2]
["S4746","(20S)-Protopanaxadiol","e7","L6400-04","in 10mM DMSO","P-gp","Transmembrane Transporters","20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.",460.73,"30636-90-9",{"v":92,"d":"92.00"},199.68,"<1","N/A","http://selleckchem.com/products/20s-protopanaxadiol.html","C30H52O3","free base","20-Epiprotopanaxadiol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4CCC23C",5.789,0,2,4]
["S4759","p-Coumaric Acid","f7","L6400-04","in 10mM DMSO","Anti-infection","Microbiology","p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.",164.16,"501-98-4",{"v":32,"d":"32.00"},194.93,"<1","N/A","http://selleckchem.com/products/p-coumaric-acid.html","C9H8O3","free base","4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid","OC(=O)\\C=C\\C1=CC=C(O)C=C1",1.685,1,1,2]
["S4761","Thymoquinone","g7","L6400-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects.",{"v":164.2,"d":"164.20"},"490-91-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/thymoquinone.html","C10H12O2","free base","N/A","CC(C)C1=CC(=O)C(=CC1=O)C",2.288,2,0,1]
["S4765","Syringaldehyde","h7","L6400-04","in 10mM DMSO","COX","Immunology & Inflammation","Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.  Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities.",182.17,"134-96-3",{"v":36,"d":"36.00"},197.62,"N/A","N/A","http://selleckchem.com/products/syringaldehyde.html","C9H10O4","free base","Syringic aldehyde","COC1=C(O)C(=CC(=C1)C=O)OC",1.314,3,1,3]
["S4766","Gibberellic acid","a8","L6400-04","in 10mM DMSO","Others","Others","Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.",346.37,"77-06-5",{"v":69,"d":"69.00"},199.21,"N/A","N/A","http://selleckchem.com/products/gibberellic-acid.html","C19H22O6","free base","Gibberellin, Gibberellin A3, GA3","CC12C(O)C=CC3(OC1=O)C4CCC5(O)CC4(CC5=C)C(C23)C(O)=O",0.442,3,1,1]
["S4771","β-thujaplicin","b8","L6400-04","in 10mM DMSO","DNA Methyltransferase","Epigenetics","β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods.  Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.",{"v":164.2,"d":"164.20"},"499-44-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/beta-thujaplicin.html","C10H12O2","free base","Hinokitiol, 4-Isopropyltropolone","CC(C)C1=CC=CC(=O)C(=C1)O",1.896,1,1,1]
["S4783","Benzyl isothiocyanate","c8","L6400-04","in 10mM DMSO","Antibiotics","Microbiology","Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.",149.21,"622-78-6",{"v":29,"d":"29.00"},194.36,"N/A","N/A","http://selleckchem.com/products/benzyl-isothiocyanate.html","C8H7NS","free base","Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester","S=C=NCC1=CC=CC=C1",{"v":0,"d":"0.000"},0,0,0]
["S4809","3-Indolepropionic acid","d8","L6400-04","in 10mM DMSO","Others","Others","3-Indolepropionic acid (IPA, indole-3-propionic acid), a gut microbial metabolite, is a potent neuroprotective antioxidant and plant auxin.",189.21,"830-96-6",{"v":37,"d":"37.00"},195.55,"N/A","N/A","http://selleckchem.com/products/3-indolepropionic-acid.html","C11H11NO2","free base","indole-3-propionic acid, Indolepropionic acid","OC(=O)CCC1=C[NH]C2=C1C=CC=C2",{"v":0,"d":"0.000"},0,0,0]
["S4815","L-Cysteine HCl","e8","L6400-04","in 10mM DMSO","Others","Others","L-cysteine Hydrochloride, also known as L-CYSTEINE or Cysteine HCL (anhydrous), is classified as a cysteine or a cysteine derivative that increases glutathione levels and is important for lung and brain function and liver detoxification.",157.62,"52-89-1",{"v":31,"d":"31.00"},196.68,"N/A","N/A","http://selleckchem.com/products/l-cysteine-hcl.html","C3H7NO2S.ClH","hydrochloride","N/A","Cl.NC(CS)C(O)=O",-2.696,1,1,2]
["S4832","Tolmetin","f8","L6400-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.",257.28,"26171-23-3",{"v":51,"d":"51.00"},198.23,"N/A","N/A","http://selleckchem.com/products/tolmetin.html","C15H15NO3","free base","Tolectin","C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(O)=O",3.267,2,0,4]
["S4849","Levocetirizine Dihydrochloride","g8","L6400-04","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.",461.81,"130018-87-0",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/levocetirizine-dihydrochloride.html","C21H25ClN2O3.2HCl","dihydrochloride","Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S4853","Ecabet sodium","h8","L6400-04","in 10mM DMSO","ROS","Apoptosis","Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8, Ecabet sodium can also reduce apoptosis.",402.48,"86408-72-2",{"v":80,"d":"80.00"},198.77,{"v":16,"d":"16.00"},39.75,"http://selleckchem.com/products/ecabet-sodium.html","C20H27O5S.Na","sodium salt","TA-2711, TA-2711E","[Na+].CC(C)C1=CC2=C(C=C1[S]([O-])(=O)=O)C3(C)CCCC(C)(C3CC2)C(O)=O",2.477,1,0,3]
["S4854","Bedaquiline fumarate","a9","L6400-04","in 10mM DMSO","Bacterial","Microbiology","Bedaquiline fumarate (TMC-207), an oral diarylquinoline,  is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.",671.58,"845533-86-0",{"v":100,"d":"100.00"},{"v":148.9,"d":"148.90"},"<1","N/A","http://selleckchem.com/products/bedaquiline-fumarate.html","C32H31BrN2O2.C4H4O4","fumarate","TMC-207","COC1=C(C=C2C=C(Br)C=CC2=N1)C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=C5C=CC=CC5=CC=C4.OC(=O)\\C=C\\C(O)=O",3.937,4,0,10]
["S4862","Squalene","b9","L6400-04","in 10mM DMSO","Fungal","Microbiology","Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.",410.72,"111-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/squalene.html","C30H50","free base","Spinacene, Supraene, trans-Squalene","CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(C)\\CC\\C=C(C)\\CCC=C(C)C",11.331,0,0,15]
["S4866","Nicarbazin","c9","L6400-04","in 10mM DMSO","Parasite","Microbiology","Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug.",426.38,"330-95-0",{"v":9,"d":"9.00"},21.11,"<1","N/A","http://selleckchem.com/products/nicarbazin.html","C13H10N4O5.C6H8N2O","salt","N/A","CC1=NC(=NC(=C1)C)O.[O-][N+](=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)[N+]([O-])=O)C=C2",3.207,3,3,4]
["S4900","Tenovin-6","d9","L6400-04","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.",454.63,"1011557-82-6",{"v":98,"d":"98.00"},215.56,{"v":98,"d":"98.00"},215.56,"http://selleckchem.com/products/tenovin-6.html","C25H34N4O2S","free base","N/A","Cl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",{"v":5.7,"d":"5.700"},2,3,11]
["S4940","Maltol","e9","L6400-04","in 10mM DMSO","Antioxidant","PI3K/Akt/mTOR","Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.",126.11,"118-71-8",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/maltol.html","C6H6O3","Pyrone","Larixinic acid, Palatone, Veltol","CC1=C(O)C(=O)C=CO1",-0.222,2,1,0]
["S4941","Farnesol","f9","L6400-04","in 10mM DMSO","Antibiotics","Microbiology","Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.",222.37,"4602-84-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/farnesol.html","C15H26O","free base","N/A","CC(C)=CCCC(/C)=C/CCC(/C)=C/CO",{"v":4.76,"d":"4.760"},0,1,7]
["S4957","Linalool","g9","L6400-04","in 10mM DMSO","NMDAR","Neuronal Signaling","Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.",154.25,"78-70-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/linalool.html","C10H18O","free base","Phantol","CC(C)=CCCC(C)(O)C=C",2.735,0,0,4]
["S4964","Lactobionic acid","h9","L6400-04","in 10mM DMSO","MMP","Proteases","Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. Lactobionic acid inhibits matrix-metalloproteinase (MMP) activity.",{"v":358.3,"d":"358.30"},"96-82-2",{"v":71,"d":"71.00"},198.16,"N/A","N/A","http://selleckchem.com/products/lactobionic-acid.html","C12H22O12","Disaccharides","Galactosylgluconic acid","OCC(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)C(O)C(O)=O",{"v":-4.56,"d":"-4.560"},3,8,8]
["S4966","4-Methylesculetin","a10","L6400-04","in 10mM DMSO","Immunology & Inflammation related,Interleukins,Peroxidases","Metabolism","4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.",192.17,"529-84-0",{"v":38,"d":"38.00"},197.74,"N/A","N/A","http://selleckchem.com/products/methylesculetin.html","C10H8O4","free base","N/A","CC1=CC(=O)OC2=C1C=C(O)C(=C2)O",1.862,2,2,0]
["S4970","Nerol","b10","L6400-04","in 10mM DMSO","Fungal,ROS","Apoptosis","Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis.",154.25,"106-25-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/nerol.html","C10H18O","free base","Cis-Geraniol, Neryl alcohol","CC(C)=CCC\\C(C)=C/CO",2.934,0,1,4]
["S4977","Efonidipine","c10","L6400-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.",631.66,"111011-63-3",{"v":100,"d":"100.00"},158.31,"N/A","N/A","http://selleckchem.com/products/efonidipine.html","C34H38N3O7P","free base","NZ-105","CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",4.956,4,1,11]
["S4981","Cyclogalegenol","d10","L6400-04","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.",490.71,"78574-94-4",{"v":98,"d":"98.00"},199.71,"<1","N/A","http://selleckchem.com/products/cyclogalegenol.html","C30H50O5","Cyclohexanol","Astramembrangenin, Cyclosieversigenin","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(O)CCC56CC46CCC23C",2.635,1,3,2]
["S4990","TBHQ","e10","L6400-04","in 10mM DMSO","Nrf2","Immunology & Inflammation","Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.",166.22,"1948-33-0",{"v":33,"d":"33.00"},198.53,"N/A","N/A","http://selleckchem.com/products/tbhq.html","C10H14O2","free base","Tert-butylhydroquinone","CC(C)(C)C1=C(O)C=CC(=C1)O",2.746,0,2,1]
["S5060","Metadoxine","f10","L6400-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.  Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.",298.29,"74536-44-0",{"v":59,"d":"59.00"},197.79,"N/A","N/A","http://selleckchem.com/products/metadoxine.html","C8H11NO3.C5H7NO3","salt","Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat","CC1=C(O)C(=C(CO)C=N1)CO.OC(=O)C2CCC(=O)N2",-1.243,3,4,3]
["S5063","Trelagliptin succinate","g10","L6400-04","in 10mM DMSO","DPP","Proteases","Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).",475.47,"1029877-94-8",{"v":95,"d":"95.00"},{"v":199.8,"d":"199.80"},{"v":95,"d":"95.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/trelagliptin-succinate.html","C18H20FN5O2.C4H6O4","succinate","SYR472","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC(=CC=C3C#N)F)C1=O.OC(=O)CCC(O)=O",-1.362,4,1,6]
["S5066","Pramipexole dihydrochloride","h10","L6400-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.",284.25,"104632-25-9",{"v":56,"d":"56.00"},197.01,"N/A","N/A","http://selleckchem.com/products/pramipexole-dihydrochloride.html","C10H17N3S.2HCl","dihydrochloride","SND919","Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",2.147,1,2,3]
["S5073","Donepezil","a11","L6400-04","in 10mM DMSO","AChR","Neuronal Signaling","Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.",379.49,"120014-06-4",{"v":75,"d":"75.00"},197.63,"N/A","N/A","http://selleckchem.com/products/donepezil.html","C24H29NO3","free base","Aricept, Donepezilo","COC1=CC2=C(C=C1OC)C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)C2",4.569,3,0,6]
["S5079","Sitagliptin","b11","L6400-04","in 10mM DMSO","DPP","Proteases","Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.",407.31,"486460-32-6",{"v":81,"d":"81.00"},198.87,"N/A","N/A","http://selleckchem.com/products/sitagliptin.html","C16H15F6N5O","free base","MK-0431","NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F",{"v":1.93,"d":"1.930"},3,1,5]
["S5104","Tea polyphenol","c11","L6400-04","in 10mM DMSO","Others","Others","Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.","N/A","84650-60-2",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},{"v":100,"d":"100.00"},"N/A","http://selleckchem.com/products/tea-polyphenol.html","N/A","N/A","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S5105","Proanthocyanidins","d11","L6400-04","in 10mM DMSO","Bacterial","Microbiology","Proanthocyanidins (PAs), also known as condensed tannins, are a class of polyphenols found in a variety of plants. They are very powerful antioxidants that remove harmful free oxygen radicals from cells.",594.52,"20347-71-1",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},"<1","N/A","http://selleckchem.com/products/proanthocyanidins.html","C30H26O13","free base","condensed tannins","OC1C(O)C(OC2CC3=C(OC2C4=CC=C(O)C(=C4)O)C=C(O)C=C3O)(OC5=C1C(=CC(=C5)O)O)C6=CC=C(O)C(=C6)O",{"v":0,"d":"0.000"},0,0,0]
["S5113","Propyl gallate","e11","L6400-04","in 10mM DMSO","PPAR","Metabolism","Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.",{"v":212.2,"d":"212.20"},"121-79-9",{"v":42,"d":"42.00"},197.93,"N/A","N/A","http://selleckchem.com/products/propyl-gallate.html","C10H12O5","free base","Gallic acid propyl esterZ, n-Propyl gallate","CCCOC(=O)C1=CC(=C(O)C(=C1)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5121","Phytol","f11","L6400-04","in 10mM DMSO","PPAR","Metabolism","Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.",296.53,"150-86-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/phytol.html","C20H40O","free base","Trans-Phytol","CC(C)CCCC(C)CCCC(C)CCC\\C(C)=C\\CO",{"v":0,"d":"0.000"},0,0,0]
["S5133","Sodium erythorbate","g11","L6400-04","in 10mM DMSO","Others","Others","Sodium erythorbate (NaE, D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium) is the sodium of erythorbic acid, a highly refined food-grade chemical closely related to vitamin C, synthesized from sugar, and used as a color fixative in preparing cured meats.",198.11,"6381-77-7",{"v":12,"d":"12.00"},60.57,"N/A","N/A","http://selleckchem.com/products/sodium-erythorbate.html","C6H7O6.Na","sodium salt","D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium, Sodium isoascorbate","OCC(O)C1OC(=O)C(=C1O[Na])O",{"v":0,"d":"0.000"},0,0,0]
["S5144","Neferine","h11","L6400-04","in 10mM DMSO","Akt,Apoptosis related,Autophagy,HIV,NF-κB,Nrf2","NF-κB","Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.",624.77,"2292-16-2",{"v":100,"d":"100.00"},160.06,"N/A","N/A","http://selleckchem.com/products/neferine.html","C38H44N2O6","free base","(R)-1,2-Dimethoxyaporphine","COC1=CC=C(CC2N(C)CCC3=C2C=C(OC4=CC(=CC=C4O)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C(=C3)OC)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5157","Thymol","a2","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.",150.22,"89-83-8",{"v":30,"d":"30.00"},199.71,"N/A","N/A","http://selleckchem.com/products/thymol.html","C10H14O","free base","2-isopropyl-5-methylphenol, IPMP","CC(C)C1=CC=C(C)C=C1O",{"v":0,"d":"0.000"},0,0,0]
["S5174","Kojic acid","b2","L6400-05","in 10mM DMSO","Fungal,Tyrosinase","Proteases","Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.",142.11,"501-30-4",{"v":28,"d":"28.00"},197.03,"N/A","N/A","http://selleckchem.com/products/kojic-acid.html","C6H6O4","free base","N/A","OCC1=CC(=O)C(=CO1)O",{"v":0,"d":"0.000"},0,0,0]
["S5221","Diludine","c2","L6400-05","in 10mM DMSO","Others","Others","Diludine (Ethidine, Diethone) is a synthetic antioxidant agent.",253.29,"1149-23-1",{"v":28,"d":"28.00"},110.54,{"v":-1,"d":"-1.00"},-3.95,"https://www.selleckchem.com/products/diludine.html","C13H19NO4","Esters","Ethidine, Diethone","CCOC(=O)C1=C(C)NC(=C(C1)C(=O)OCC)C",1.285,4,1,6]
["S5237","Dihydroartemisinic acid","d2","L6400-05","in 10mM DMSO","Others","Others","Dihydroartemisinic acid is a natural product from Artemisia annua and the main direct precursor of artemisinin, which is a medicinal herb that is widely used to treat Malaria.",236.35,"85031-59-0",{"v":47,"d":"47.00"},198.86,"<1","N/A","http://selleckchem.com/products/dihydroartemisinic-acid.html","C15H24O2","free base","N/A","CC1CCC(C(C)C(O)=O)C2C=C(C)CCC12",3.927,1,0,2]
["S5241","Lapatinib ditosylate monohydrate","e2","L6400-05","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate)is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.",943.48,"388082-78-8",{"v":100,"d":"100.00"},105.99,{"v":-1,"d":"-1.00"},-1.06,"https://www.selleckchem.com/products/lapatinib-ditosylate-monohydrate.html","C43H44ClFN4O11S3","ditosylate monohydrate","Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate","O.CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC5=C(C=C4)N=CN=C5NC6=CC(=C(OCC7=CC(=CC=C7)F)C=C6)Cl",9.132,6,2,13]
["S5304","2-Acetylphenothiazine (ML171)","f2","L6400-05","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.",241.31,"6631-94-3",{"v":48,"d":"48.00"},198.91,"N/A","N/A","http://selleckchem.com/products/2-acetylphenothiazine-ml171.html","C14H11NOS","free base","2-APT","CC(=O)C1=CC=C2SC3=C(NC2=C1)C=CC=C3",3.408,1,1,1]
["S5312","Urolithin A","g2","L6400-05","in 10mM DMSO","Mitophagy","Autophagy","Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.",{"v":228.2,"d":"228.20"},"1143-70-0",{"v":45,"d":"45.00"},{"v":197.2,"d":"197.20"},"<1","N/A","http://selleckchem.com/products/urolithin-a.html","C13H8O4","free base","3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin","OC1=CC=C2C(=C1)OC(=O)C3=CC(=CC=C23)O",2.466,2,2,0]
["S5314","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","h2","L6400-05","in 10mM DMSO","ROS","Immunology & Inflammation","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS), including peroxyl radicals, and scavenging them to form more stable free radicals.",236.35,"148081-72-5",{"v":47,"d":"47.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hthq-1-o-hexyl-2-3-5-trimethylhydroquinone.html","C15H24O2","Hydroquinones","N/A","CCCCCCOC1=CC(=C(O)C(=C1C)C)C",5.271,1,1,6]
["S5318","Acacetin","a3","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.",284.26,"480-44-4",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"N/A","N/A","http://selleckchem.com/products/acacetin.html","C16H12O5","free base","Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",2.636,3,2,2]
["S5325","Nitisinone","b3","L6400-05","in 10mM DMSO","Others","Metabolism","Nitisinone (NTBC, Nitisone, SC0735) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.",329.23,"104206-65-7",{"v":65,"d":"65.00"},197.43,"<1","N/A","http://selleckchem.com/products/nitisinone.html","C14H10F3NO5","free base","NTBC, Nitisone, SC0735","[O-][N+](=O)C1=CC(=CC=C1C(=O)C2C(=O)CCCC2=O)C(F)(F)F",{"v":2.53,"d":"2.530"},3,0,4]
["S5345","(+/-)-nerolidol","c3","L6400-05","in 10mM DMSO","Parasite","Microbiology","(+/-)-nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.",222.37,"7212-44-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/nerolidol.html","C15H26O","free base","Peruviol","CC(C)=CCC/C(C)=C/CCC(C)(O)C=C",4.561,0,0,7]
["S5369","Ethoxyquin","d3","L6400-05","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Ethoxyquin (Santoquin, Santoflex, Quinol) is an antioxidant used as a food preservative.  Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).",217.31,"91-53-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/ethoxyquin.html","C14H19NO","free base","Santoquin, Santoflex, Quinol","CCOC1=CC2=C(NC(C)(C)C=C2C)C=C1",3.221,1,1,2]
["S5373","Pseudolaric Acid B","e3","L6400-05","in 10mM DMSO","Fungal","Microbiology","Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.",432.46,"82508-31-4",{"v":86,"d":"86.00"},198.86,"<1","N/A","https://www.selleckchem.com/products/pseudolaric-acid-b.html","C23H28O8","Diterpenoids","N/A","COC(=O)C1=CCC23CCC(C(C)(OC2=O)\\C=C\\C=C(C)\\C(O)=O)C3(CC1)OC(C)=O",2.793,7,0,7]
["S5380","7-Hydroxyflavone","f3","L6400-05","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines.",238.24,"6665-86-7",{"v":47,"d":"47.00"},197.28,"N/A","N/A","http://selleckchem.com/products/7-hydroxyflavone.html","C15H10O3","free base","N/A","OC1=CC=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3",2.894,2,1,1]
["S5410","Chloramphenicol sodium succinate","g3","L6400-05","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity.",445.18,"982-57-0",{"v":89,"d":"89.00"},199.92,"N/A","N/A","http://selleckchem.com/products/chloramphenicol-sodium-succinate.html","C15H15Cl2N2O8.Na","sodium salt","N/A","[Na+].OC(C(COC(=O)CCC([O-])=O)NC(=O)C(Cl)Cl)C1=CC=C(C=C1)[N+]([O-])=O",-0.225,3,2,11]
["S5440","Berberine Sulfate","h3","L6400-05","in 10mM DMSO","Bacterial","Microbiology","Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.",433.43,"633-66-9",{"v":20,"d":"20.00"},46.14,"N/A","N/A","http://selleckchem.com/products/berberine-sulfate.html","C20H18NO4.HO4S","sulfate","Umbellatine Sulfate","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4.O[S]([O-])(=O)=O",1.111,4,0,2]
["S5451","Ferulic acid methyl ester","a4","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid,  which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.",208.21,"2309-07-1",{"v":41,"d":"41.00"},196.92,{"v":41,"d":"41.00"},196.92,"http://selleckchem.com/products/ferulic-acid-methylester.html","C11H12O4","free base","Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate","COC(=O)\\C=C\\C1=CC=C(O)C(=C1)OC",1.894,3,1,4]
["S5452","Sanguinarine chloride","b4","L6400-05","in 10mM DMSO","phosphatase,ROS","Immunology & Inflammation","Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.",367.78,"5578-73-4",{"v":5,"d":"5.00"},{"v":13.6,"d":"13.60"},"<1","N/A","http://selleckchem.com/products/sanguinarine-chloride.html","C20H14NO4.Cl","chloride","N/A","[Cl-].C[N+]1=CC2=C3OCOC3=CC=C2C4=CC=C5C=C6OCOC6=CC5=C14",1.313,4,0,0]
["S5453","Hyperoside","c4","L6400-05","in 10mM DMSO","NF-κB","NF-κB","Hyperoside (Hyperin, Quercetin 3-galactoside), a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.Hyperoside can inhibit activation of the NF-κB signaling pathway.",464.38,"482-36-0",{"v":92,"d":"92.00"},198.11,{"v":1,"d":"1.00"},2.15,"http://selleckchem.com/products/hyperoside.html","C21H20O12","free base","Hyperin, Quercetin 3-galactoside","OCC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S5456","Isobavachalcone","d4","L6400-05","in 10mM DMSO","Bacterial","Microbiology","Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.",324.37,"20784-50-3",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/isobavachalcone.html","C20H20O4","free base","Corylifolinin","CC(C)=CCC1=C(O)C(=CC=C1O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.832,1,3,5]
["S5457","Curculigoside","e4","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Curculigoside (Curculigoside A), a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.",466.44,"85643-19-2",{"v":93,"d":"93.00"},199.38,{"v":15,"d":"15.00"},32.16,"http://selleckchem.com/products/curculigoside.html","C22H26O11","free base","Curculigoside A","COC1=C(C(=O)OCC2=CC(=CC=C2OC3OC(CO)C(O)C(O)C3O)O)C(=CC=C1)OC",0.822,6,5,9]
["S5458","Verbascoside","f4","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.",624.59,"61276-17-3",{"v":100,"d":"100.00"},160.11,{"v":100,"d":"100.00"},160.11,"http://selleckchem.com/products/verbascoside.html","C29H36O15","free base","Acteoside, Kusaginin","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(CO)C2OC(=O)\\C=C\\C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",0.484,6,9,11]
["S5460","Vitexin-2-O-rhaMnoside","g4","L6400-05","in 10mM DMSO","Others","Others","Vitexin-2-O-rhamnoside (2''-O-Rhamnosylvitexin, Apigenin-8-C-glucoside) is one of the main components of flavonoid of the leaves of Crataegus pinnatifida Bge. var major N. E. Br. It has many biological and pharmacological activities, such as antioxidation and treating heart disease.",578.52,"64820-99-1",{"v":100,"d":"100.00"},172.85,{"v":100,"d":"100.00"},172.85,"http://selleckchem.com/products/vitexin-2-o-rhamnoside.html","C27H30O14","free base","2''-O-Rhamnosylvitexin, Apigenin-8-C-glucoside","CC1OC(OC2C(O)C(O)C(CO)OC2C3=C(O)C=C(O)C4=C3OC(=CC4=O)C5=CC=C(O)C=C5)C(O)C(O)C1O",{"v":-0.84,"d":"-0.840"},5,9,5]
["S5464","Psoralidin","h4","L6400-05","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.",336.34,"18642-23-4",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/psoralidin.html","C20H16O5","free base","N/A","CC(C)=CCC1=CC2=C(OC(=O)C3=C2OC4=C3C=CC(=C4)O)C=C1O",4.917,3,2,2]
["S5465","Morroniside","a5","L6400-05","in 10mM DMSO","MMP,Pyroptosis","Proteases","Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.",406.38,"25406-64-8",{"v":81,"d":"81.00"},199.32,{"v":81,"d":"81.00"},199.32,"http://selleckchem.com/products/morroniside.html","C17H26O11","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)OC(O)CC13",{"v":-2.28,"d":"-2.280"},6,4,5]
["S5478","Dantrolene sodium","b5","L6400-05","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.",336.23,"14663-23-1",{"v":67,"d":"67.00"},199.27,{"v":-1,"d":"-1.00"},-2.97,"https://www.selleckchem.com/products/s5478-dantrolene-sodium.html","C14H9N4NaO5","free base","F 440","[Na+].[O-]C1=NC(=O)CN1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+]([O-])=O",1.769,4,0,4]
["S5501","Hydrocortisone acetate","c5","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Hydrocortisone Acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.",{"v":404.5,"d":"404.50"},"50-03-3",{"v":80,"d":"80.00"},197.78,"N/A","N/A","https://www.selleckchem.com/products/hydrocortisone-acetate.html","C23H32O6","free base","Cortisol 21-acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C",1.662,4,1,4]
["S5520","Phenidone","d5","L6400-05","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.",162.19,"92-43-3",{"v":32,"d":"32.00"},{"v":197.3,"d":"197.30"},"N/A","N/A","http://selleckchem.com/products/phenidone.html","C9H10N2O","free base","1-phenyl-3-pyrazolidinone","O=C1CCN(N1)C2=CC=CC=C2",1.112,1,1,1]
["S5529","Galangin","e5","L6400-05","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.",270.24,"548-83-4",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/galangin.html","C15H10O5","free base","3,5,7-trihydroxyflavone; Norizalpinin","OC1=CC2=C(C(=C1)O)C(=O)C(=C(O2)C3=CC=CC=C3)O",2.114,2,3,1]
["S5550","Ethyl gallate","f5","L6400-05","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8, -9, and -3 and the Bcl-2 interacting domain (Bid).",198.17,"831-61-8",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},"N/A","N/A","https://www.selleckchem.com/products/ethyl-gallate.html","C9H10O5","Ester","Phyllemblin, gallic acid ethyl ester","CCOC(=O)C1=CC(=C(O)C(=C1)O)O",1.308,2,3,3]
["S5604","Diphenylamine Hydrochloride","g5","L6400-05","in 10mM DMSO","OXPHOS","Apoptosis","Diphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355), a derivative of aniline, is widely used as an industrial antioxidant, dye mordant and reagent and is also employed in agriculture as a fungicide and antihelmintic. Diphenylamine can inhibits oxidative phosphorylationsignificantly, although its inhibition potency was weaker than that of NSAIDs with a diphenylamine structure.",205.68,"537-67-7",{"v":41,"d":"41.00"},199.34,{"v":1,"d":"1.00"},4.86,"http://www.selleckchem.com/products/diphenylamine-hydrochloride.html","C12H12ClN","Hydrochloride","N-Phenylbenzenamine, Anilinobenzene, C.I. 10355","Cl.N(C1=CC=CC=C1)C2=CC=CC=C2",3.762,0,1,2]
["S5616","4-Methylcatechol","h5","L6400-05","in 10mM DMSO","Others","Others","4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.",124.14,"452-86-8",{"v":24,"d":"24.00"},193.33,{"v":-1,"d":"-1.00"},-8.06,"https://www.selleckchem.com/products/4-methylcatechol.html","C7H8O2","free base","P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol","CC1=CC(=C(O)C=C1)O",1.832,0,2,0]
["S5623","Bedaquiline","a6","L6400-05","in 10mM DMSO","ATPase","Transmembrane Transporters","Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).",{"v":555.5,"d":"555.50"},"843663-66-1",{"v":12,"d":"12.00"},{"v":21.6,"d":"21.60"},"<1","N/A","https://www.selleckchem.com/products/bedaquiline.html","C32H31BrN2O2","free base","TMC-207, R207910","COC1=NC2=CC=C(Br)C=C2C=C1C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=CC=CC5=CC=CC=C45",6.933,2,0,8]
["S5651","Dexrazoxane","b6","L6400-05","in 10mM DMSO","Others","Others","Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.",268.27,"24584-09-6",{"v":54,"d":"54.00"},201.29,"<1","N/A","http://selleckchem.com/products/dexrazoxane.html","C11H16N4O4","free base","ICRF-187","CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-2.104,4,2,3]
["S5686","Tryptanthrin","c6","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.",248.24,"13220-57-0",{"v":8,"d":"8.00"},32.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tryptanthrin.html","C15H8N2O2","Free Base","N/A","O=C1N2C3=C(C=CC=C3)C(=O)C2=NC4=CC=CC=C14",2.331,3,0,0]
["S5688","Tropolone (NSC 89303)","d6","L6400-05","in 10mM DMSO","Others","Metabolism","Tropolone (NSC 89303, 2-Hydroxytropone, Purpurocatechol), a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion. It is able to inhibit ferric iron reduction by catecholates, lowering the redox potential of the iron couple.",122.12,"533-75-5",{"v":24,"d":"24.00"},196.53,"N/A","N/A","https://www.selleckchem.com/products/tropolone.html","C7H6O2","free base","2-Hydroxytropone, Purpurocatechol","OC1=CC=CC=CC1=O",0.741,1,1,0]
["S5703","Carvedilol Phosphate","e6","L6400-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.",513.48,"610309-89-2",{"v":100,"d":"100.00"},198.23,{"v":-1,"d":"-1.00"},-1.98,"https://www.selleckchem.com/products/carvedilol-phosphate.html","C24H29N2O8P.1/2H2O","Phosphate","N/A","COC1=C(OCCNCC(O)COC2=CC=CC3=C2C4=C([NH]3)C=CC=C4)C=CC=C1.O[P](O)(O)=O",{"v":4.28,"d":"4.280"},3,3,10]
["S5709","Norgestrel","f6","L6400-05","in 10mM DMSO","ROS","Immunology & Inflammation","Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.",312.45,"6533-00-2",{"v":62,"d":"62.00"},198.43,"<1","N/A","http://selleckchem.com/products/norgestrel.html","C21H28O2","free base","WY-3707, SH-70850, SH-850, FH 122-A","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S5713","Pravastatin","g6","L6400-05","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.",424.53,"81093-37-0",{"v":85,"d":"85.00"},200.22,{"v":85,"d":"85.00"},200.22,"http://www.selleckchem.com/products/pravastatin.html","C23H36O7","Free Base","CS-514","CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC(O)=O)C12",2.156,3,3,11]
["S5715","Atorvastatin","h6","L6400-05","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.",558.64,"134523-00-5",{"v":100,"d":"100.00"},179.01,"<1","N/A","http://www.selleckchem.com/products/atorvastatin.html","C33H35FN2O5","Free Base","N/A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC(O)=O)C3=CC=C(F)C=C3)C4=CC=CC=C4",5.555,2,3,12]
["S5742","Deferoxamine mesylate (Ba 33112)","a7","L6400-05","in 10mM DMSO","Autophagy,Beta Amyloid,Ferroptosis,HIF","Autophagy","Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.",656.79,"138-14-7",{"v":100,"d":"100.00"},152.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/deferoxamine-mesylate.html","C26H52N6O11S","mesylate","Desferrioxamine B, DFOM, NSC 644468","CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.C[S](O)(=O)=O",-1.304,5,3,23]
["S5759","Methyl linoleate","b7","L6400-05","in 10mM DMSO","Others","Others","Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes.",294.47,"112-63-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/methyl-linoleate.html","C19H34O2","Free Base","Linoleic acid methyl ester","CCCCC/C=C\\C\\C=C/CCCCCCCC(=O)OC",6.641,2,0,15]
["S5761","Citric acid","c7","L6400-05","in 10mM DMSO","Others","Others","Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle.",192.12,"77-92-9",{"v":38,"d":"38.00"},197.79,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/citric-acid.html","C6H8O7","Free Base","N/A","OC(=O)CC(O)(CC(O)=O)C(O)=O",-1.319,3,0,5]
["S5771","Sulforaphane","d7","L6400-05","in 10mM DMSO","HDAC,Heme Oxygenase,NF-κB,Nrf2,ROS","Immunology & Inflammation","Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,",177.29,"4478-93-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/sulforaphane.html","C6H11NOS2","Free Base","N/A","C[S](=O)CCCCN=C=S",1.157,2,0,5]
["S5791","Cyclic Pifithrin-α hydrobromide","e7","L6400-05","in 10mM DMSO","p53","Apoptosis","Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.",349.29,"511296-88-1",{"v":27,"d":"27.00"},{"v":77.3,"d":"77.30"},{"v":1,"d":"1.00"},2.86,"http://www.selleckchem.com/products/cyclic-pifithrin-hydrobromide.html","C16H17BrN2S","hydrobromide","N/A","Br.CC1=CC=C(C=C1)C2=C[N]3C(=N2)SC4=C3CCCC4",4.616,1,0,1]
["S5804","N-Acetylcysteine amide","f7","L6400-05","in 10mM DMSO","HIF,Immunology & Inflammation related,NF-κB,ROS","Immunology & Inflammation","N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.",162.21,"38520-57-9",{"v":32,"d":"32.00"},197.28,{"v":32,"d":"32.00"},197.28,"http://www.selleckchem.com/products/n-acetylcysteine-amide.html","C5H10N2O2S","Free Base","N/A","CC(=O)NC(CS)C(N)=O",-1.205,2,2,3]
["S5811","Kevetrin hydrochloride","g7","L6400-05","in 10mM DMSO","p53","Apoptosis","Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.",179.67,"66592-89-0",{"v":36,"d":"36.00"},200.37,{"v":36,"d":"36.00"},200.37,"http://www.selleckchem.com/products/kevetrin-hydrochloride.html","C5H10ClN3S","hydrochloride","Thioureidobutyronitrile HCl","Cl.NC(=N)SCCCC#N",1.105,0,1,4]
["S5834","p-Coumaric acid ethyl ester","h7","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties.",192.21,"7362-39-2",{"v":38,"d":"38.00"},{"v":197.7,"d":"197.70"},{"v":1,"d":"1.00"},{"v":5.2,"d":"5.20"},"http://www.selleckchem.com/products/p-coumaric-acid-ethyl-ester.html","C11H12O3","ethyl ester","N/A","CCOC(=O)\\C=C\\C1=CC=C(O)C=C1",{"v":2.26,"d":"2.260"},2,1,4]
["S5842","Cabergoline","a8","L6400-05","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.",{"v":451.6,"d":"451.60"},"81409-90-7",{"v":90,"d":"90.00"},199.29,{"v":1,"d":"1.00"},2.21,"http://www.selleckchem.com/products/cabergoline.html","C26H37N5O2","Free Base","FCE-21336","CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=C[NH]C4=C3C2=CC=C4)N(CC=C)C1",3.036,2,2,8]
["S5909","Anagliptin","b8","L6400-05","in 10mM DMSO","DPP","Proteases","Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.",383.45,"739366-20-2",{"v":77,"d":"77.00"},200.81,{"v":20,"d":"20.00"},52.16,"http://www.selleckchem.com/products/anagliptin.html","C19H25N7O2","Free Base","N/A","CC1=N[N]2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCCC3C#N",-0.629,4,2,6]
["S5928","Zerumbone","c8","L6400-05","in 10mM DMSO","Others","Others","Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities.",218.33,"471-05-6",{"v":44,"d":"44.00"},201.53,{"v":1,"d":"1.00"},4.58,"http://www.selleckchem.com/products/zerumbone.html","C15H22O","Free Base","N/A","CC\\1=C/CC(C)(C)\\C=C\\C(=O)\\C(=C\\CC1)C",4.455,1,0,0]
["S5929","4-Octyl Itaconate","d8","L6400-05","in 10mM DMSO","Nrf2","Immunology & Inflammation","4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.",242.31,"3133-16-2",{"v":48,"d":"48.00"},198.09,{"v":1,"d":"1.00"},4.13,"http://www.selleckchem.com/products/4-octyl-Itaconate.html","C13H22O4","Free Base","N/A","CCCCCCCCOC(=O)CC(=C)C(O)=O",3.497,3,0,11]
["S5943","Bromhexine","e8","L6400-05","in 10mM DMSO","Others","Others","Bromhexine is an expectorant/mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus",376.13,"3572-43-8",{"v":75,"d":"75.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://www.selleck.cn/products/bromhexine.html","C14H20Br2N2","Free Base","N/A","CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2",4.512,0,1,3]
["S6018","2,3,4-Trihydroxybenzoic acid","f8","L6400-05","in 10mM DMSO","Others","Others","2,3,4-Trihydroxybenzoic acid is a phenol constituent of Pachysandra terminalis with antioxidant activity.",170.12,"610-02-6",{"v":34,"d":"34.00"},199.86,"N/A","N/A","http://www.selleck.cn/products/2-3-4-trihydroxybenzoic-acid.html","C7H6O5","free base","N/A","OC(=O)C1=C(O)C(=C(O)C=C1)O",0.733,1,3,1]
["S6104","(±)-α-Tocopherol","g8","L6400-05","in 10mM DMSO","Vitamin","Metabolism","(±)-α-Tocopherol is a biologically active form of vitamin E, which is a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.",430.71,"10191-41-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/tocopherol.html","C29H50O2","free base","N/A","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S6125","Glycerol trilinoleate","h8","L6400-05","in 10mM DMSO","Others","Others","Glycerol trilinoleate (Trilinolein) is a triacylglycerol and has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. It is also an antioxidant.",879.38,"537-40-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/glycerol-trilinoleate.html","C57H98O6","free base","Trilinolein","CCCCC/C=C\\C\\C=C/CCCCCCCC(=O)OCC(COC(=O)CCCCCCC\\C=C/C/C=C\\CCCCC)OC(=O)CCCCCCC\\C=C/C/C=C\\CCCCC",19.591,6,0,50]
["S6163","Traumatic acid","a9","L6400-05","in 10mM DMSO","Others","Others","Traumatic acid (Trans-2-dodecenedioic acid) is a plant hormone that was first isolated from damaged green beans. It is a potent wound healing agent and an intermediate in prostaglandin synthesis.",228.28,"6402-36-4",45.66,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/traumatic-acid.html","C12H20O4","free base","Trans-2-dodecenedioic acid","OC(=O)CCCCCCCC\\C=C\\C(O)=O",3.267,2,0,10]
["S6182","L-Gulono-1,4-lactone","b9","L6400-05","in 10mM DMSO","Others","Others","L-Gulono-1,4-lactone (L-Gulonolactone, L-Gulono-gamma-lactone, reduced ascorbic acid) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals.",178.14,"1128-23-0",35.63,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/l-gulono-1-4-lactone.html","C6H10O6","free base","L-Gulonolactone, L-Gulono-gamma-lactone, reduced ascorbic acid","OCC(O)C1OC(=O)C(O)C1O",-2.229,2,4,2]
["S6202","Butylated hydroxytoluene","c9","L6400-05","in 10mM DMSO","Others","Others","Butylated hydroxytoluene (dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT) is a lipophilic organic compound that is useful for its antioxidant properties.",220.35,"128-37-0",44.07,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/butylated-hydroxytoluene.html","C15H24O","free base","dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT","CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C",4.875,0,1,2]
["S6228","Indole-2-carboxylic acid","d9","L6400-05","in 10mM DMSO","Lipoxygenase","Metabolism","Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation.",161.16,"1477-50-5",32.23,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/indole-2-carboxylic-acid.html","C9H7NO2","free base","N/A","OC(=O)C1=CC2=C([NH]1)C=CC=C2",2.044,1,1,1]
["S6229","Lauryl gallate","e9","L6400-05","in 10mM DMSO","Others","Others","Lauryl gallate (Dodecyl gallate) is the ester of dodecanol and gallic acid that exhibits both potent chain-breaking and preventive antioxidant activity.",338.44,"1166-52-5",67.69,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/lauryl-gallate.html","C19H30O5","free base","Dodecyl gallate","CCCCCCCCCCCCOC(=O)C1=CC(=C(O)C(=C1)O)O",5.937,2,3,13]
["S6254","Hydrocinnamic acid","f9","L6400-05","in 10mM DMSO","Fungal","Microbiology","Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite.",150.17,"501-52-0",30.03,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/hydrocinnamic-acid.html","C9H10O2","free base","3-phenylpropionic acid, Benzylacetic acid","OC(=O)CCC1=CC=CC=C1",{"v":1.95,"d":"1.950"},1,0,3]
["S6264","Rutin hydrate","g9","L6400-05","in 10mM DMSO","Others","Others","Rutin (Quercetin-3-O-rutinoside, Rutoside, Sophorin) is a glycoside found in a wide variety of plants including citrus fruit.",610.52,"207671-50-9",{"v":122.1,"d":"122.10"},{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/rutin-hydrate.html","C27H30O16.xH2O","free base","Quercetin-3-O-rutinoside, Rutoside, Sophorin","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-0.424,6,10,6]
["S6281","Sodium Thiocyanate","h9","L6400-05","in 10mM DMSO","Interleukins,ROS","Immunology & Inflammation","Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS.",81.07,"540-72-7",16.21,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/sodium-thiocyanate.html","CNNaS","free base","Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate","[Na]SC#N",0.625,0,0,0]
["S6338","3,4-Dihydroxyhydrocinnamic acid","a10","L6400-05","in 10mM DMSO","Others","Others","3,4-Dihydroxyhydrocinnamic acid (Dihydrocaffeic acid) is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties.",182.17,"1078-61-1",36.43,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/3-4-dihydroxyhydrocinnamic-acid.html","C9H10O4","free base","Dihydrocaffeic acid","OC(=O)CCC1=CC(=C(O)C=C1)O",1.466,1,2,3]
["S6348","(+)-Delta-Tocopherol","b10","L6400-05","in 10mM DMSO","Others","Others","(+)-Delta-Tocopherol (8-Methyltocol) is the orally bioavailable delta form of the naturally-occurring fat-soluble vitamin E, mostly found in soybean and corn oils, with potential antioxidant activity.",402.65,"119-13-1",80.53,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/delta-tocopherol.html","C27H46O2","free base","8-Methyltocol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(O1)C(=CC(=C2)O)C",9.468,1,1,12]
["S6400","Glucosamine","c10","L6400-05","in 10mM DMSO","HIF","Angiogenesis","Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.",179.17,"3416-24-8",{"v":23,"d":"23.00"},128.37,{"v":36,"d":"36.00"},200.93,"http://www.selleck.cn/products/glucosamine.html","C6H13NO5","Free Base","2-amino-2-deoxy-D-glucose","NC(C=O)C(O)C(O)C(O)CO",-3.081,1,5,5]
["S6402","2-Aminoethanethiol","d10","L6400-05","in 10mM DMSO","Others","Others","2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.",77.15,"60-23-1",{"v":15,"d":"15.00"},194.43,{"v":15,"d":"15.00"},194.43,"http://www.selleck.cn/products/2-aminoethanethiol.html","C2H7NS","Free Base","cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine","NCCS",-0.216,0,1,1]
["S6420","AGI 1067","e10","L6400-05","in 10mM DMSO","Others","Immunology & Inflammation","AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.",616.91,"216167-82-7",{"v":100,"d":"100.00"},{"v":162.1,"d":"162.10"},"<1","N/A","http://www.selleck.cn/products/agi-1067.html","C35H52O5S2","Free Base","N/A","CC(C)(C)C1=C(O)C(=CC(=C1)SC(C)(C)SC2=CC(=C(OC(=O)CCC(O)=O)C(=C2)C(C)(C)C)C(C)(C)C)C(C)(C)C",9.634,3,1,13]
["S6426","Hesperidin methylchalcone","f10","L6400-05","in 10mM DMSO","Others","Others","Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity.",624.59,"24292-52-2",{"v":100,"d":"100.00"},160.11,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/hesperidin-methylchalcone.html","C29H36O15","Free Base","N/A","COC1=C(O)C=C(/C=C/C(=O)C2=C(OC)C=C(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)C=C2O)C=C1",0.154,7,8,10]
["S6441","Riboflavin Tetrabutyrate","g10","L6400-05","in 10mM DMSO","Others","Others","Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.",656.72,"752-56-7",{"v":100,"d":"100.00"},152.27,"<1","N/A","http://www.selleck.cn/products/riboflavin-tetrabutyrate.html","C33H44N4O10","Tetrabutyrate","N/A","CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(CN1C2=C(C=C(C)C(=C2)C)N=C3C(=O)NC(=O)N=C13)OC(=O)CCC",5.754,12,1,21]
["S6472","Tinoridine hydrochloride","h10","L6400-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.",352.88,"25913-34-2",{"v":18,"d":"18.00"},51.01,"<1","N/A","http://www.selleck.cn/products/tinoridine-hydrochloride.html","C17H21ClN2O2S","hydrochloride","Y-3642 HCl","Cl.CCOC(=O)C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2",3.265,2,1,5]
["S6527","Kobe2602","a11","L6400-05","in 10mM DMSO","Ras","Cell Cycle","Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).",419.31,"454453-49-7",{"v":84,"d":"84.00"},200.33,"<1","N/A","http://www.selleck.cn/products/kobe2602.html","C14H9F4N5O4S","free base","N/A","[O-][N+](=O)C1=CC(=CC(=C1NNC(=S)NC2=CC=C(F)C=C2)[N+]([O-])=O)C(F)(F)F",4.976,0,3,8]
["S6538","B-Raf IN 1","b11","L6400-05","in 10mM DMSO","Raf","MAPK","B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively. It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα.",515.53,"950736-05-7",{"v":100,"d":"100.00"},193.98,"<1","N/A","http://www.selleck.cn/products/b-rafin-1.html","C29H24F3N5O","free base","N/A","CN(C)CC1=CC=C(C=C1)C2=C3N=CC=C([N]3N=C2)C4=CC(=CC=C4)NC(=O)C5=CC=CC(=C5)C(F)(F)F",5.368,3,1,7]
["S6557","ML355","c11","L6400-05","in 10mM DMSO","Lipoxygenase","Metabolism","ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.",441.52,"1532593-30-8",{"v":88,"d":"88.00"},199.31,"<1","N/A","http://www.selleck.cn/products/ml355.html","C21H19N3O4S2","free base","N/A","COC1=C(O)C(=CC=C1)CNC2=CC=C(C=C2)[S](=O)(=O)NC3=NC4=CC=CC=C4S3",4.077,4,3,7]
["S6601","(±)-Equol","d11","L6400-05","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.",242.27,"94105-90-5",{"v":48,"d":"48.00"},198.13,"<1","N/A","https://www.selleckchem.com/products/equol-1.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=C(C2)C=CC(=C3)O",3.211,1,2,1]
["S7030","RG-7112","e11","L6400-05","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7149","NSC 319726","f11","L6400-05","in 10mM DMSO","p53","Apoptosis","NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.",234.32,"71555-25-4",{"v":19,"d":"19.00"},81.09,"<1","N/A","http://selleckchem.com/products/nsc319726.html","C11H14N4S","free base","N/A","CC(=N\\NC(=S)N1CCC1)/C2=NC=CC=C2",1.906,2,1,4]
["S7171","Setanaxib (GKT137831)","g11","L6400-05","in 10mM DMSO","Ferroptosis,NADPH-oxidase,ROS","Immunology & Inflammation","Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.",394.85,"1218942-37-0",{"v":78,"d":"78.00"},197.54,"<1","N/A","http://selleckchem.com/products/gkt137831.html","C21H19ClN4O2","free base","GKT831","CN(C)C1=CC=CC(=C1)C2=C3C(=O)N(NC3=CC(=O)N2C)C4=CC=CC=C4Cl",2.366,2,1,3]
["S7205","Idasanutlin (RG-7388)","h11","L6400-05","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7224","Deltarasin","a2","L6400-06","in 10mM DMSO","PDE,Ras","Metabolism","Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.",603.75,"1440898-61-2",{"v":100,"d":"100.00"},165.63,"<1","N/A","http://selleckchem.com/products/deltarasin.html","C40H37N5O","free base","N/A","C1CC(CCN1)C(COC2=CC=C(C=C2)C3=NC4=C(C=CC=C4)[N]3CC5=CC=CC=C5)[N]6C7=CC=CC=C7N=C6C8=CC=CC=C8",{"v":8.52,"d":"8.520"},3,1,9]
["S7243","Ferrostatin-1 (Fer-1)","b2","L6400-06","in 10mM DMSO","Ferroptosis","Metabolism","Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.",262.35,"347174-05-4",{"v":52,"d":"52.00"},198.21,"<1","N/A","https://www.selleckchem.com/products/ferrostatin-1.html","C15H22N2O2","free base","N/A","CCOC(=O)C1=CC=C(NC2CCCCC2)C(=C1)N",2.954,2,2,5]
["S7262","Vidofludimus","c2","L6400-06","in 10mM DMSO","COVID-19,Dehydrogenase","Metabolism","Vidofludimus (SC12267, 4SC-101) is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.",355.36,"717824-30-1",{"v":100,"d":"100.00"},{"v":281.4,"d":"281.40"},"<1","N/A","http://selleckchem.com/products/vidofludimus.html","C20H18FNO4","free base","SC12267, 4SC-101","COC1=CC(=CC=C1)C2=CC(=C(NC(=O)C3=C(CCC3)C(O)=O)C=C2)F",3.878,3,1,5]
["S7291","TAK-632","d2","L6400-06","in 10mM DMSO","Raf","MAPK","TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.",554.52,"1228591-30-7",{"v":100,"d":"100.00"},180.34,"<1","N/A","http://selleckchem.com/products/tak-632.html","C27H18F4N4O3S","free base","N/A","FC1=C(NC(=O)CC2=CC=CC(=C2)C(F)(F)F)C=C(OC3=C(C#N)C4=C(C=C3)N=C(NC(=O)C5CC5)S4)C=C1",{"v":5.74,"d":"5.740"},4,2,8]
["S7293","ZCL278","e2","L6400-06","in 10mM DMSO","Rho","Cell Cycle","ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.",584.89,"587841-73-4",{"v":100,"d":"100.00"},170.97,"<1","N/A","http://selleckchem.com/products/zcl278.html","C21H19BrClN5O4S2","free base","N/A","CC1=CC(=NC(=N1)N[S](=O)(=O)C2=CC=C(NC(=S)NC(=O)COC3=C(Cl)C=C(Br)C=C3)C=C2)C",4.809,6,3,9]
["S7309","BAY 87-2243","f2","L6400-06","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7319","EHop-016","g2","L6400-06","in 10mM DMSO","Rho","Cell Cycle","EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.",430.55,"1380432-32-5",{"v":86,"d":"86.00"},199.74,"<1","N/A","http://selleckchem.com/products/ehop-016.html","C25H30N6O","free base","N/A","CC[N]1C2=C(C=CC=C2)C3=C1C=CC(=C3)NC4=NC(=NC=C4)NCCCN5CCOCC5",4.407,3,2,8]
["S7331","K-Ras(G12C) inhibitor 12","h2","L6400-06","in 10mM DMSO","Ras","Cell Cycle","K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).",449.67,"1469337-95-8",{"v":27,"d":"27.00"},60.04,"<1","N/A","http://selleckchem.com/products/k-ras-g12c-inhibitor-12.html","C15H17ClIN3O3","free base","N/A","OC1=CC(=C(I)C=C1NCC(=O)N2CCN(CC2)C(=O)C=C)Cl",1.819,2,2,4]
["S7351","JSH-23","a3","L6400-06","in 10mM DMSO","NF-κB","NF-κB","JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.",240.34,"749886-87-1",{"v":48,"d":"48.00"},199.72,"<1","N/A","http://selleckchem.com/products/jsh-23.html","C16H20N2","free base","N/A","CC1=CC=C(NCCCC2=CC=CC=C2)C(=C1)N",3.739,0,2,5]
["S7352","Bay 11-7085","b3","L6400-06","in 10mM DMSO","IκB/IKK","NF-κB","BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.",249.33,"196309-76-9",{"v":50,"d":"50.00"},200.54,"<1","N/A","http://selleckchem.com/products/bay-11-7085.html","C13H15NO2S","free base","Bay 11-7083","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",2.635,2,0,3]
["S7380","Leupeptin Hemisulfate","c3","L6400-06","in 10mM DMSO","Cathepsin B,Cysteine Protease,Serine Protease","Proteases","Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.",475.59,"103476-89-7",{"v":95,"d":"95.00"},199.75,{"v":95,"d":"95.00"},199.75,"http://selleckchem.com/products/leupeptin-hemisulfate.html","C20H38N6O4.1/2H2SO4","sulfate","N/A","CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O",0.977,4,5,15]
["S7397","Sorafenib (BAY 43-9006)","d3","L6400-06","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1","N/A","http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7414","Caffeic Acid Phenethyl Ester","e3","L6400-06","in 10mM DMSO","NF-κB","NF-κB","Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.",284.31,"104594-70-9",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/caffeic-acid-phenethyl-ester.html","C17H16O4","free base","CAPE, Phenylethyl Caffeate","OC1=CC=C(/C=C/C(=O)OCCC2=CC=CC=C2)C=C1O",3.573,2,2,6]
["S7445","APX-3330","f3","L6400-06","in 10mM DMSO","DNA/RNA Synthesis,NF-κB","DNA Damage/DNA Repair","APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.",378.46,"136164-66-4",{"v":75,"d":"75.00"},198.17,"<1","N/A","http://selleckchem.com/products/e3330.html","C21H30O6","free base","E3330","CCCCCCCCCC(=C/C1=C(C)C(=O)C(=C(OC)C1=O)OC)\\C(O)=O",4.663,5,0,12]
["S7448","CORM-3","g3","L6400-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.",294.61,"475473-26-8",{"v":38,"d":"38.00"},128.98,"<1","N/A","http://selleckchem.com/products/corm-3.html","C5H4ClNO5Ru","free base","N/A","Cl[Ru]1(NCC(=O)O1)(C=O)(C=O)C=O",-0.104,5,1,3]
["S7489","YH239-EE","h3","L6400-06","in 10mM DMSO","MDM2/MDMX","Apoptosis","YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.",504.41,"1364488-67-4",{"v":100,"d":"100.00"},198.25,"<1","N/A","http://selleckchem.com/products/yh239-ee.html","C25H27Cl2N3O4","free base","N/A","CCOC(=O)C1=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(=O)NC(C)(C)C)C3=C([NH]1)C=C(Cl)C=C3",4.912,4,2,9]
["S7501","HO-3867","a4","L6400-06","in 10mM DMSO","Apoptosis related,STAT","JAK/STAT","HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.",464.55,"1172133-28-6",{"v":13,"d":"13.00"},27.98,"<1","N/A","http://selleckchem.com/products/ho-3867.html","C28H30F2N2O2","free base","N/A","CC1(C)C=C(CN2C\\C(=C/C3=CC=C(F)C=C3)C(=O)C(/C2)=C/C4=CC=C(F)C=C4)C(C)(C)N1O",5.209,1,0,4]
["S7513","Trelagliptin","b4","L6400-06","in 10mM DMSO","DPP","Proteases","Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).",357.38,"865759-25-7",{"v":71,"d":"71.00"},198.67,"<1","N/A","http://selleckchem.com/products/trelagliptin.html","C18H20FN5O2","free base","SYR-472","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC(=CC=C3C#N)F)C1=O",1.476,2,1,3]
["S7534","BAPTA-AM","c4","L6400-06","in 10mM DMSO","Others","Others","BAPTA-AM is a selective, membrane-permeable calcium chelator.",764.68,"126150-97-8",{"v":20,"d":"20.00"},26.15,"<1","N/A","http://selleckchem.com/products/bapta-am.html","C34H40N2O18","free base","N/A","CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=C(OCCOC2=C(C=CC=C2)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C=CC=C1",1.886,18,0,31]
["S7551","Piperlongumine","d4","L6400-06","in 10mM DMSO","CRM1,ROS","Immunology & Inflammation","Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.",317.34,"20069-09-4",{"v":16,"d":"16.00"},50.42,"<1","N/A","http://selleckchem.com/products/piperlongumine.html","C17H19NO5","free base","PPLGM, Piplartine","COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O",2.135,5,0,5]
["S7553","GDC-0623","e4","L6400-06","in 10mM DMSO","MEK","MAPK","GDC-0623 (G-868) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.",456.21,"1168091-68-6",{"v":91,"d":"91.00"},199.47,"<1","N/A","http://selleckchem.com/products/gdc-0623.html","C16H14FIN4O3","free base","G-868","OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)[N]3C=NC=C3C=C1",2.284,3,3,6]
["S7606","RBC8","f4","L6400-06","in 10mM DMSO","Ras","GPCR & G Protein","RBC8 is a selective inhibitor of the GTPases RalA and RalB by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA.",424.45,"361185-42-4",{"v":84,"d":"84.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/rbc8.html","C25H20N4O3","free base","N/A","COC1=CC(=C(OC)C=C1)C2C(=C(N)OC3=C2C(=N[NH]3)C4=CC=C5C=CC=CC5=C4)C#N",4.253,4,2,4]
["S7607","BQU57","g4","L6400-06","in 10mM DMSO","Ras","Cell Cycle","BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.",{"v":334.1,"d":"334.10"},"1637739-82-2",{"v":66,"d":"66.00"},197.55,"<1","N/A","http://selleckchem.com/products/bqu57.html","C16H13F3N4O","free base","N/A","C[N]1N=C(C)C2=C1OC(=C(C#N)C2C3=CC=C(C=C3)C(F)(F)F)N",2.861,2,1,2]
["S7649","MI-773 (SAR405838)","h4","L6400-06","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7655","Telaglenastat (CB-839)","a5","L6400-06","in 10mM DMSO","Autophagy,Glutaminase","Proteases","Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.",571.57,"1439399-58-2",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/cb-839.html","C26H24F3N7O3S","free base","N/A","FC(F)(F)OC1=CC(=CC=C1)CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2",5.597,8,2,13]
["S7660","Obeticholic Acid","b5","L6400-06","in 10mM DMSO","Autophagy,FXR","Metabolism","Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.",420.63,"459789-99-2",{"v":84,"d":"84.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/obeticholic-acid.html","C26H44O4","free base","INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid","CCC1C(O)C2C3CCC(C(C)CCC(O)=O)C3(C)CCC2C4(C)CCC(O)CC14",{"v":4.79,"d":"4.790"},1,2,5]
["S7672","Omaveloxolone (RTA-408)","c5","L6400-06","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.",554.71,"1474034-05-3",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/omaveloxolone-rta-408.html","C33H44F2N2O3","free base","N/A","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C3(C)CCC5C(C)(C)C(=O)C(=CC45C)C#N)NC(=O)C(C)(F)F",5.339,3,1,2]
["S7684","Salirasib","d5","L6400-06","in 10mM DMSO","Autophagy,PPMTase,Ras","Cell Cycle","Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.",358.54,"162520-00-5","The physical form of the compound is fat, and can be dissolved in any proportion in DMSO","N/A","N/A","N/A","http://selleckchem.com/products/salirasib.html","C22H30O2S","free base","Farnesylthiosalicylic acid, FTS","CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC1=CC=CC=C1C(O)=O",{"v":7.12,"d":"7.120"},1,0,10]
["S7686","ML141","e5","L6400-06","in 10mM DMSO","Apoptosis related,p38 MAPK,Rho","Cell Cycle","ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.",407.49,"71203-35-5",{"v":81,"d":"81.00"},198.78,"<1","N/A","http://selleckchem.com/products/ml141.html","C22H21N3O3S","free base","CID-2950007","COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)[S](N)(=O)=O)C4=CC=CC=C4",{"v":3.87,"d":"3.870"},4,1,5]
["S7699","Liproxstatin-1","f5","L6400-06","in 10mM DMSO","Ferroptosis","Metabolism","Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.",340.85,"950455-15-9",{"v":68,"d":"68.00"},{"v":199.5,"d":"199.50"},"<1","N/A","http://selleckchem.com/products/liproxstatin-1.html","C19H21ClN4","free base","N/A","ClC1=CC(=CC=C1)CNC2=NC3=C(NC24CCNCC4)C=CC=C3",2.598,1,3,3]
["S7719","CCG-1423","g5","L6400-06","in 10mM DMSO","Rho","Cell Cycle","CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.",454.75,"285986-88-1",{"v":90,"d":"90.00"},197.91,"<1","N/A","http://selleckchem.com/products/ccg-1423.html","C18H13ClF6N2O3","free base","N/A","CC(ONC(=O)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C(=O)NC2=CC=C(Cl)C=C2",4.553,3,2,7]
["S7723","PRIMA-1","h5","L6400-06","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7724","Eprenetapopt (APR-246)","a6","L6400-06","in 10mM DMSO","Apoptosis related,Autophagy,p53","Apoptosis","Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.",199.25,"5291-32-7",{"v":40,"d":"40.00"},200.75,"N/A","N/A","http://selleckchem.com/products/apr-246-prima-1met.html","C10H17NO3","free base","PRIMA-1MET","COCC1(CO)N2CCC(CC2)C1=O",-0.364,2,1,3]
["S7743","CCT196969","b6","L6400-06","in 10mM DMSO","Raf,Src","MAPK","CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.",513.52,"1163719-56-9",{"v":100,"d":"100.00"},194.73,"<1","N/A","http://selleckchem.com/products/cct196969.html","C27H24FN7O3","free base","N/A","CC(C)(C)C1=N[N](C(=C1)NC(=O)NC2=CC=C(OC3=C4N=CC(=O)NC4=NC=C3)C=C2F)C5=CC=CC=C5",4.782,6,3,6]
["S7828","Licochalcone A","c6","L6400-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.",{"v":338.4,"d":"338.40"},"58749-22-7",{"v":67,"d":"67.00"},197.99,"<1","N/A","http://selleckchem.com/products/licochalcone-a.html","C21H22O4","free base","N/A","COC1=C(/C=C/C(=O)C2=CC=C(O)C=C2)C=C(C(=C1)O)C(C)(C)C=C",4.667,2,2,6]
["S7843","BI-847325","d6","L6400-06","in 10mM DMSO","Aurora Kinase,MEK","MAPK","BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.",464.56,"1207293-36-4",{"v":19,"d":"19.00"},{"v":40.9,"d":"40.90"},"<1","N/A","http://selleckchem.com/products/bi-847325.html","C29H28N4O2","free base","N/A","CCNC(=O)C#CC1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4",4.041,2,3,8]
["S7864","Oltipraz","e6","L6400-06","in 10mM DMSO","Nrf2","Immunology & Inflammation","Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.",226.34,"64224-21-1",{"v":39,"d":"39.00"},172.31,"<1","N/A","http://selleckchem.com/products/oltipraz.html","C8H6N2S3","free base","N/A","CC1=C(SSC1=S)C2=NC=CN=C2",2.225,2,0,1]
["S7867","Oleuropein","f6","L6400-06","in 10mM DMSO","Anti-infection,Apoptosis related,Aromatase,PPAR","Immunology & Inflammation","Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.",540.51,"32619-42-4",{"v":100,"d":"100.00"},185.01,{"v":100,"d":"100.00"},185.01,"http://selleckchem.com/products/oleuropein.html","C25H32O13","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C\\C)C1CC(=O)OCCC3=CC(=C(O)C=C3)O",0.166,7,6,11]
["S7875","NVP-CGM097","g6","L6400-06","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7909","Dp44mT","h6","L6400-06","in 10mM DMSO","Others","Others","Dp44mT is a potent iron chelator, which shows selective antitumor activity.",285.37,"152095-12-0",{"v":57,"d":"57.00"},199.74,"<1","N/A","http://selleckchem.com/products/dp44mt.html","C14H15N5S","free base","N/A","CN(C)C(=S)N\\N=C(/C1=NC=CC=C1)C2=CC=CC=N2",2.968,3,1,5]
["S7947","PX-12","a7","L6400-06","in 10mM DMSO","COVID-19,Thioredoxin","Metabolism","PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent thioredoxin-1 (Trx-1) inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.",188.31,"141400-58-0",{"v":38,"d":"38.00"},201.79,"<1","N/A","http://selleckchem.com/products/px-12.html","C7H12N2S2","free base","DB05448, 1-methyl propyl 2-imidazolyl disulfide","CCC(C)SSC1=NC=C[NH]1",2.641,1,1,4]
["S7964","PLX7904","b7","L6400-06","in 10mM DMSO","Raf","MAPK","PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.",512.53,"1393465-84-3",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/plx7904.html","C24H22F2N6O3S","free base","PB04","CCN(C)[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CN=C(N=C4)C5CC5",2.291,6,2,8]
["S7995","Ripasudil (K-115) hydrochloride dihydrate","c7","L6400-06","in 10mM DMSO","ROCK","Cell Cycle","Ripasudil (K-115) hydrochloride dihydrate is a potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.",395.88,"887375-67-9",{"v":26,"d":"26.00"},65.68,{"v":79,"d":"79.00"},199.56,"http://selleckchem.com/products/ripasudil-k-115.html","C15H18FN3O2S.ClH.2H2O","Hydrochloride dihydrate","N/A","O.O.Cl.CC1CNCCCN1[S](=O)(=O)C2=CC=CC3=CN=CC(=C23)F",0.739,3,1,2]
["S8000","Tenovin-1","d7","L6400-06","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).",369.48,"380315-80-0",{"v":74,"d":"74.00"},200.28,"<1","N/A","http://selleckchem.com/products/tenovin-1.html","C20H23N3O2S","free base","N/A","CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",4.287,2,3,6]
["S8036","Butein","e7","L6400-06","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.",272.25,"487-52-5",{"v":55,"d":"55.00"},202.02,"<1","N/A","http://selleckchem.com/products/butein.html","C15H12O5","free base","N/A","OC1=CC(=C(C=C1)C(=O)\\C=C\\C2=CC(=C(O)C=C2)O)O",2.734,1,4,3]
["S8037","Necrostatin-1","f7","L6400-06","in 10mM DMSO","Apoptosis related,Autophagy,IDO/TDO,RIP kinase,TNF-alpha","Apoptosis","Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.",259.33,"4311-88-0",{"v":51,"d":"51.00"},196.66,"<1","N/A","http://selleckchem.com/products/necrostatin-1.html","C13H13N3OS","free base","Nec-1","CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S",2.472,1,2,2]
["S8065","Nutlin-3b","g7","L6400-06","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8078","Bardoxolone Methyl","h7","L6400-06","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8106","NSC59984","a8","L6400-06","in 10mM DMSO","p53","Apoptosis","NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.",265.27,"803647-40-7",{"v":53,"d":"53.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/nsc59984.html","C12H15N3O4","free base","N/A","CN1CCN(CC1)C(=O)\\C=C\\C2=CC=C(O2)[N+]([O-])=O",1.083,2,0,3]
["S8149","NSC348884","b8","L6400-06","in 10mM DMSO","Apoptosis related,p53","Apoptosis","NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.",636.79,"81624-55-7",{"v":100,"d":"100.00"},157.04,"<1","N/A","http://selleckchem.com/products/nsc348884.html","C38H40N10","free base","N/A","CC1=CC2=C(C=C1)N=C(CN(CCN(CC3=NC4=C([NH]3)C=C(C)C=C4)CC5=NC6=C([NH]5)C=C(C)C=C6)CC7=NC8=C([NH]7)C=C(C)C=C8)[NH]2",7.572,4,4,11]
["S8155","RSL3","c8","L6400-06","in 10mM DMSO","Ferroptosis,Peroxidases","Metabolism","RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.",440.88,"1219810-16-8",{"v":88,"d":"88.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/rsl3.html","C23H21ClN2O5","free base","(1S,3R)-RSL3","COC(=O)C1CC2=C([NH]C3=C2C=CC=C3)C(N1C(=O)CCl)C4=CC=C(C=C4)C(=O)OC",3.558,5,1,6]
["S8173","Verubecestat (MK-8931) Trifluoroacetate","d8","L6400-06","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.",523.43,"2095432-65-6",{"v":81,"d":"81.00"},154.75,"<1","N/A","http://selleckchem.com/products/verubecestat-mk-8931.html","C19H18F5N5O5S","Trifluoroacetat","MK-8931","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3.OC(=O)C(F)(F)F",2.198,5,2,4]
["S8177","BH3I-1","e8","L6400-06","in 10mM DMSO","Bcl-2","Apoptosis","BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.",400.31,"300817-68-9",{"v":64,"d":"64.00"},159.88,"<1","N/A","http://selleckchem.com/products/bh3i-1.html","C15H14BrNO3S2","free base","N/A","CC(C)C(N1C(=S)S\\C(=C/C2=CC=C(Br)C=C2)C1=O)C(O)=O",4.604,2,0,4]
["S8178","Wnt agonist 1","f8","L6400-06","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.",386.83,"2095432-75-8",{"v":77,"d":"77.00"},199.05,"<1","N/A","http://selleckchem.com/products/wnt-agonist-1.html","C19H18N4O3.HCl","hydrochloride","BML-284 HCL, BML-284 hydrochloride, AMBMP hydrochloride, AMBMP HCL","Cl.COC1=CC(=CC=C1)C2=NC(=NC(=C2)NCC3=CC=C4OCOC4=C3)N",3.837,5,2,5]
["S8254","FIN56","g8","L6400-06","in 10mM DMSO","Ferroptosis","Metabolism","FIN56 is a specific inducer of ferroptosis .",517.66,"1083162-61-1",{"v":100,"d":"100.00"},193.18,"<1","N/A","http://selleckchem.com/products/fin56.html","C25H31N3O5S2","free base","N/A","ON=C1C2=C(C=CC(=C2)[S](=O)(=O)NC3CCCCC3)C4=C1C=C(C=C4)[S](=O)(=O)NC5CCCCC5",4.528,5,2,6]
["S8279","(±)-Shikonin","h8","L6400-06","in 10mM DMSO","Anti-infection,Chloride Channel,COVID-19,NF-κB,PKM,Proteasome,TNF-alpha","Metabolism","(±)-Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.",{"v":288.3,"d":"288.30"},"54952-43-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/shikonin.html","C16H16O5","free base","Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["S8288","VLX1570","a9","L6400-06","in 10mM DMSO","DUB","Ubiquitin","VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.",469.39,"1431280-51-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://selleckchem.com/products/vlx1570.html","C23H17F2N3O6","free base","N/A","[O-][N+](=O)C1=C(F)C=CC(=C1)\\C=C2/CCN(C\\C(=C/C3=CC=C(F)C(=C3)[N+]([O-])=O)C2=O)C(=O)C=C",4.385,2,0,5]
["S8289","NQDI-1","b9","L6400-06","in 10mM DMSO","ASK","Apoptosis","NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.",319.31,"175026-96-7",{"v":21,"d":"21.00"},65.77,"<1","N/A","http://selleckchem.com/products/nqdi-1.html","C19H13NO4","free base","N/A","CCOC(=O)C1=C2C3=C(C=CC=C3)C(=O)C4=C2C(=CC=C4)NC1=O",2.469,4,1,3]
["S8291","Atractylenolide I","c9","L6400-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.",{"v":230.3,"d":"230.30"},"73069-13-3",{"v":46,"d":"46.00"},199.74,"<1","N/A","http://selleckchem.com/products/atractylenolide-i.html","C15H18O2","free base","N/A","CC1=C2CC3C(=C)CCCC3(C)C=C2OC1=O",3.323,2,0,0]
["S8302","SR-12813","d9","L6400-06","in 10mM DMSO","HMG-CoA Reductase","Metabolism","SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.",504.53,"126411-39-0",{"v":100,"d":"100.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/sr-12813.html","C24H42O7P2","free base","N/A","CCO[P](=O)(OCC)C(=CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)[P](=O)(OCC)OCC",4.891,4,1,13]
["S8303","Kobe0065","e9","L6400-06","in 10mM DMSO","Ras","Cell Cycle","Kobe0065 is an H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.",449.79,"436133-68-5",{"v":89,"d":"89.00"},197.87,"<1","N/A","http://selleckchem.com/products/kobe0065.html","C15H11ClF3N5O4S","free base","N/A","CC1=C(Cl)C=C(NC(=S)NNC2=C(C=C(C=C2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)C=C1",5.921,0,3,8]
["S8319","7,8-Dihydroxyflavone","f9","L6400-06","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","7,8-Dihydroxyflavone (7,8-DHF) acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).",254.24,"38183-03-8",{"v":50,"d":"50.00"},196.66,"<1","N/A","http://selleckchem.com/products/7-8-dihydroxyflavone.html","C15H10O4","free base","7,8-DHF","OC1=CC=C2C(=O)C=C(OC2=C1O)C3=CC=CC=C3",2.652,2,2,1]
["S8358","WNK463","g9","L6400-06","in 10mM DMSO","Serine/threonin kinase","Apoptosis","WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4) with IC50 of 5nM, 1nM, 6nM, and 9nM.",463.46,"2012607-27-9",{"v":92,"d":"92.00"},198.51,"<1","N/A","http://selleckchem.com/products/wnk463.html","C21H24F3N7O2","free base","N/A","CC(C)(C)NC(=O)C1=CN=C[N]1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F",2.173,6,1,6]
["S8370","BGP-15 2HCl","h9","L6400-06","in 10mM DMSO","PARP","DNA Damage/DNA Repair","BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.",351.27,"66611-37-8",{"v":70,"d":"70.00"},199.28,{"v":70,"d":"70.00"},199.28,"http://selleckchem.com/products/bgp-15.html","C14H22N4O2.2HCl","dihydrochloride","N/A","Cl.Cl.NC(=N\\OCC(O)CN1CCCCC1)/C2=CC=CN=C2",1.097,3,2,6]
["S8382","ML390","a10","L6400-06","in 10mM DMSO","Dehydrogenase","Metabolism","ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.",{"v":406.4,"d":"406.40"},"2029049-79-2",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/ml390.html","C21H21F3N2O3","free base","N/A","FC(F)(F)OC1=CC=C(C=C1)C(=O)NCCC(=O)NC2CCCC3=C2C=CC=C3",5.065,3,2,7]
["S8403","MX69","b10","L6400-06","in 10mM DMSO","MDM2/MDMX","Apoptosis","MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment.",474.57,"1005264-47-0",{"v":95,"d":"95.00"},200.18,"<1","N/A","http://selleckchem.com/products/mx69.html","C27H26N2O4S","free base","N/A","CC1=C(C)C=C(N[S](=O)(=O)C2=CC3=C(NC(C4CC=CC34)C5=CC=C(C=C5)C(O)=O)C=C2)C=C1",5.082,3,2,5]
["S8405","RRx-001","c10","L6400-06","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. RRx-001 triggers apoptosis and exhibits anticancer activity.",268.02,"925206-65-1",{"v":53,"d":"53.00"},197.75,"<1","N/A","http://selleckchem.com/products/rrx-001.html","C5H6BrN3O5","free base","N/A","[O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O",0.473,1,0,3]
["S8432","Troglitazone (CS-045)","d10","L6400-06","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,PPAR","Metabolism","Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced ferroptosis and lipid peroxidation in Pfa1 cells.",441.54,"97322-87-7",{"v":88,"d":"88.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/troglitazone-cs-045.html","C24H27NO5S","free base","Rezulin, Romglizone, Prelay, Romozin","CC1=C(O)C(=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C)C",5.682,4,2,5]
["S8447","8-OH-DPAT (8-Hydroxy-DPAT)","e10","L6400-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.",247.38,"78950-78-4",{"v":49,"d":"49.00"},198.08,"<1","N/A","http://selleckchem.com/products/8-oh-dpat-8-hydroxy-dpat.html","C16H25NO","free base","N/A","CCCN(CCC)C1CCC2=CC=CC(=C2C1)O",4.287,0,1,5]
["S8469","CCG-203971","f10","L6400-06","in 10mM DMSO","Rho","Cell Cycle","CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.",408.88,"1443437-74-8",{"v":81,"d":"81.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/ccg-203971.html","C23H21ClN2O3","free base","N/A","ClC1=CC=C(NC(=O)C2CCCN(C2)C(=O)C3=CC(=CC=C3)C4=CC=CO4)C=C1",4.213,3,1,4]
["S8483","CBL0137 HCl","g10","L6400-06","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8493","PD-166866 (PD166866)","h10","L6400-06","in 10mM DMSO","FGFR","Angiogenesis","PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.",396.44,"192705-79-6",{"v":14,"d":"14.00"},35.31,"<1","N/A","http://selleckchem.com/products/pd-166866.html","C20H24N6O3","free base","N/A","COC1=CC(=CC(=C1)C2=CC3=C(N=C(N)N=C3)N=C2NC(=O)NC(C)(C)C)OC",2.279,6,3,5]
["S8518","AD80","a11","L6400-06","in 10mM DMSO","c-RET,S6 Kinase,Src","Protein Tyrosine Kinase","AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.",473.43,"1384071-99-1",{"v":94,"d":"94.00"},198.55,"<1","N/A","http://selleckchem.com/products/ad80.html","C22H19F4N7O","free base","N/A","CC(C)[N]1N=C(C2=CC=C(NC(=O)NC3=CC(=CC=C3F)C(F)(F)F)C=C2)C4=C(N)N=CN=C14",4.406,4,3,5]
["S8558","Tofogliflozin(CSG 452)","b11","L6400-06","in 10mM DMSO","SGLT","GPCR & G Protein","Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.",404.45,"1201913-82-7",{"v":84,"d":"84.00"},207.69,{"v":4,"d":"4.00"},9.89,"http://selleckchem.com/products/tofogliflozin-csg-452.html","C22H26O6.H2O","hydrate","N/A","O.CCC1=CC=C(CC2=CC3=C(COC34OC(CO)C(O)C(O)C4O)C=C2)C=C1",{"v":1.92,"d":"1.920"},2,4,4]
["S8564","Verubecestat (MK-8931)","c11","L6400-06","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.",409.41,"1286770-55-5",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/verubecestat.html","C17H17F2N5O3S","free base","N/A","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3",1.314,4,2,3]
["S8580","COTI-2","d11","L6400-06","in 10mM DMSO","p53","Apoptosis","COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.",366.48,"1039455-84-9",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/coti-2.html","C19H22N6S","free base","N/A","S=C(N\\N=C/1CCCC2=C1N=CC=C2)N3CCN(CC3)C4=NC=CC=C4",3.825,3,1,4]
["S8615","Sodium dichloroacetate (DCA)","e11","L6400-06","in 10mM DMSO","Apoptosis related,Dehydrogenase,NKCC,ROS","Metabolism","Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.",150.92,"2156-56-1",{"v":30,"d":"30.00"},198.78,{"v":30,"d":"30.00"},198.78,"http://selleckchem.com/products/sodium-dichloroacetate-dca.html","C2HCl2O2.Na","sodium salt","Dichloroacetic acid, bichloroacetic acid, BCA","[Na]OC(=O)C(Cl)Cl",1.081,2,0,2]
["S8639","Diphenyleneiodonium chloride (DPI)","f11","L6400-06","in 10mM DMSO","NADPH-oxidase,NOS,ROS,TRP Channel","Immunology & Inflammation","Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).",314.55,"4673-26-1",{"v":13,"d":"13.00"},41.33,"<1","N/A","http://selleckchem.com/products/diphenyleneiodonium-chloride-dpi.html","C12H8I.Cl","chloride","N/A","[Cl-].[I+]1C2=CC=CC=C2C3=C1C=CC=C3",1.101,0,0,0]
["S8661","CA3 (CIL56)","g11","L6400-06","in 10mM DMSO","Ferroptosis,ROS,TEAD,YAP","Hippo","CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).",489.61,"300802-28-2",{"v":97,"d":"97.00"},198.12,"<1","N/A","http://selleckchem.com/products/ca3.html","C23H27N3O5S2","free base","N/A","O/N=C1/C2=CC(=CC=C2C3=C1C=C(C=C3)[S](=O)(=O)N4CCCCC4)[S](=O)(=O)N5CCCCC5",3.058,5,0,4]
["S8662","PTC-028","h11","L6400-06","in 10mM DMSO","BMI-1","Cell Cycle","PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification.",405.32,"1782970-28-8",{"v":81,"d":"81.00"},199.84,"<1","N/A","http://selleckchem.com/products/ptc-028.html","C19H12F5N5","free base","N/A","CC1=NC2=C(C=C(F)C(=C2)F)[N]1C3=CN=CC(=N3)NC4=CC=C(C=C4)C(F)(F)F",5.069,3,1,4]
["S8690","RAF709","a2","L6400-07","in 10mM DMSO","Raf","MAPK","RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.",542.55,"1628838-42-5",{"v":100,"d":"100.00"},184.31,"<1","N/A","http://selleckchem.com/products/raf709.html","C28H29F3N4O4","free base","N/A","CC1=NC=C(NC(=O)C2=CC=CC(=C2)C(F)(F)F)C=C1C3=CC(=C(OC4CCOCC4)N=C3)N5CCOCC5",{"v":3.27,"d":"3.270"},6,1,7]
["S8728","PK11000","b2","L6400-07","in 10mM DMSO","p53","Apoptosis","PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.",236.63,"38275-34-2",{"v":47,"d":"47.00"},198.62,{"v":47,"d":"47.00"},198.62,"https://www.selleckchem.com/products/pk11000.html","C6H5ClN2O4S","free base","N/A","C[S](=O)(=O)C1=NC=C(Cl)C(=N1)C(O)=O",{"v":0.82,"d":"0.820"},5,0,2]
["S8745","Naporafenib (LXH254)","c2","L6400-07","in 10mM DMSO","Raf","MAPK","Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.",502.49,"1800398-38-2",{"v":100,"d":"100.00"},199.01,"<1","N/A","http://www.selleckchem.com/products/lxh254.html","C25H25F3N4O4","Free Base","N/A","CC1=CC=C(NC(=O)C2=CC(=NC=C2)C(F)(F)F)C=C1C3=CC(=NC(=C3)OCCO)N4CCOCC4",4.061,5,2,8]
["S8749","MBQ-167","d2","L6400-07","in 10mM DMSO","Rho","Cell Cycle","MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.",338.41,"2097938-73-1",{"v":68,"d":"68.00"},200.94,"<1","N/A","http://www.selleckchem.com/products/mbq-167.html","C22H18N4","Free Base","N/A","CC[N]1C2=C(C=CC=C2)C3=CC(=CC=C13)[N]4N=NC=C4C5=CC=CC=C5",5.446,2,0,3]
["S8755","AZ304","e2","L6400-07","in 10mM DMSO","Raf","MAPK","AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies.",451.52,"942507-42-8",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://www.selleck.cn/products/az304.html","C27H25N5O2","free base","N/A","COC1=CC2=C(C=C1)C(=NC=N2)NC3=CC(=CC=C3C)NC(=O)C4=CC=CC(=C4)C(C)(C)C#N",5.524,4,2,6]
["S8790","ML385","f2","L6400-07","in 10mM DMSO","Ferroptosis,Nrf2","Immunology & Inflammation","ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.",511.59,"846557-71-9",{"v":74,"d":"74.00"},144.65,"<1","N/A","http://www.selleckchem.com/products/ml385.html","C29H25N3O4S","Free Base","N/A","CC1=C(N=C(NC(=O)CC2=CC3=C(OCO3)C=C2)S1)C4=CC=C5N(CCC5=C4)C(=O)C6=C(C)C=CC=C6",5.058,5,1,5]
["S8792","UAMC-3203","g2","L6400-07","in 10mM DMSO","Ferroptosis","Metabolism","UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 Neuroblastoma Cells.",471.66,"2271358-64-4",{"v":94,"d":"94.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://www.selleck.cn/products/uamc-3203.html","C25H37N5O2S","Free Base","N/A","O=[S](=O)(NCCN1CCNCC1)C2=CC=C(NC3CCCCC3)C(=C2)NCC4=CC=CC=C4",{"v":3.36,"d":"3.360"},2,4,10]
["S8818","V-9302","h2","L6400-07","in 10mM DMSO","Amino acid transporter","Transmembrane Transporters","V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.",538.68,"1855871-76-9",{"v":100,"d":"100.00"},185.64,{"v":100,"d":"100.00"},185.64,"http://www.selleck.cn/products/v-9302.html","C34H38N2O4","free base","N/A","CC1=CC(=CC=C1)COC2=C(CN(CCC(N)C(O)=O)CC3=CC=CC=C3OCC4=CC=CC(=C4)C)C=CC=C2",3.409,3,1,14]
["S8826","BAY-293","a3","L6400-07","in 10mM DMSO","Ras","Cell Cycle","BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM.",448.58,"2244904-70-7",{"v":90,"d":"90.00"},200.63,"<1","N/A","http://www.selleck.cn/products/bay-293.html","C25H28N4O2S","free base","N/A","CNCC1=C(C=CC=C1)C2=CSC(=C2)C(C)NC3=NC(=NC4=CC(=C(OC)C=C34)OC)C",4.522,4,2,8]
["S8864","ZT-12-037-01","b3","L6400-07","in 10mM DMSO","Serine/threonin kinase","Apoptosis","ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.",{"v":385.5,"d":"385.50"},"2328073-61-4",{"v":41,"d":"41.00"},106.36,"<1","N/A","http://www.selleck.cn/products/zt-12-037-01.html","C21H31N5O2","free base","N/A","COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)C(C)C)NC4CC4",3.359,4,2,7]
["S9021","(20R)Ginsenoside Rg3","c3","L6400-07","in 10mM DMSO","ROS","Immunology & Inflammation","(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.",785.01,"38243-03-7",{"v":10,"d":"10.00"},12.74,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rg3.html","C42H72O13","free base","OG15964","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["S9026","Hastatoside","d3","L6400-07","in 10mM DMSO","Others","Others","Hastatoside is a characteristic constituent of  V. officinalis and exhibit various biological activities including sleep-promoting, antioxidant and hepatoprotective activity.",404.37,"50816-24-5",{"v":10,"d":"10.00"},24.73,"N/A","N/A","https://www.selleckchem.com/products/hastatoside.html","C17H24O11","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)CC(=O)C13O",-2.441,6,4,5]
["S9032","Sanguinarine","e3","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.",332.33,"2447-54-3",{"v":44,"d":"44.00"},{"v":132.4,"d":"132.40"},"N/A","N/A","https://www.selleckchem.com/products/sanguinarine.html","C20H14NO4","free base","Pseudochelerythrine, Sanguinarin, Sanguinarium","C[N+]1=CC2=C3OCOC3=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4",3.987,4,0,0]
["S9034","Isochlorogenic acid C","f3","L6400-07","in 10mM DMSO","ROS","Immunology & Inflammation","Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.",516.45,"57378-72-0",{"v":10,"d":"10.00"},19.36,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-c.html","C25H24O12","free base","3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,5,9]
["S9036","(20R)Ginsenoside Rh2","g3","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","(20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.,",622.87,"112246-15-8",{"v":100,"d":"100.00"},160.55,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rh2.html","C36H62O8","free base","FG73845","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5O)C(C)(C)C4CCC23C",4.042,2,5,7]
["S9038","Calycosin","h3","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Calycosin (3'-Hydroxyformononetin), an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects.",284.26,"20575-57-9",{"v":57,"d":"57.00"},200.52,"N/A","N/A","https://www.selleckchem.com/products/calycosin.html","C16H12O5","free base","3'-Hydroxyformononetin","COC1=C(O)C=C(C=C1)C2=COC3=C(C=CC(=C3)O)C2=O",2.366,3,2,2]
["S9039","Albiflorin","a4","L6400-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.",480.46,"39011-90-0",{"v":10,"d":"10.00"},20.81,"N/A","N/A","https://www.selleckchem.com/products/albiflorin.html","C23H28O11","free base","OA10410","CC12CC(O)C3CC1(OC4OC(CO)C(O)C(O)C4O)C3(COC(=O)C5=CC=CC=C5)C(=O)O2",-1.333,6,5,7]
["S9040","Maslinic acid","b4","L6400-07","in 10mM DMSO","NF-κB","NF-κB","Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.",{"v":472.7,"d":"472.70"},"4373-41-5",{"v":10,"d":"10.00"},21.16,"N/A","N/A","https://www.selleckchem.com/products/maslinic-acid.html","C30H48O4","free base","Crategolic Acid, 2α-Hydroxyoleanoic Acid","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",{"v":5.48,"d":"5.480"},1,2,1]
["S9042","Wedelolactone","c4","L6400-07","in 10mM DMSO","Caspase,IκB/IKK","NF-κB","Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.",314.25,"524-12-9",{"v":63,"d":"63.00"},200.48,"N/A","N/A","https://www.selleckchem.com/products/wedelolactone.html","C16H10O7","free base","FW73945","COC1=CC2=C(C(=C1)O)C3=C(C(=O)O2)C4=C(O3)C=C(O)C(=C4)O",2.803,4,3,1]
["S9043","6-Shogaol","d4","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.,",276.37,"555-66-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/6-shogaol.html","C17H24O3","free base","FS42771","CCCCC/C=C/C(=O)CCC1=CC=C(O)C(=C1)OC",4.717,2,1,9]
["S9046","Berberine","e4","L6400-07","in 10mM DMSO","Bacterial","Microbiology","Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.",336.36,"2086-83-1",{"v":45,"d":"45.00"},133.78,"N/A","N/A","https://www.selleckchem.com/products/berberine.html","C20H18NO4","free base","Umbellatine","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4",3.962,4,0,2]
["S9047","Leonurine Hydrochloride","f4","L6400-07","in 10mM DMSO","Others","Others","Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.",347.79,"24735-18-0",{"v":70,"d":"70.00"},201.27,"N/A","N/A","https://www.selleckchem.com/products/leonurine-hydrochloride.html","C14H22ClN3O5","free base","SCM-198 HCl","Cl.COC1=C(O)C(=CC(=C1)C(=O)OCCCCNC(N)=N)OC",1.472,4,3,10]
["S9048","(+)-Gallocatechin","g4","L6400-07","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","(+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant.",306.27,"970-73-0",{"v":10,"d":"10.00"},32.65,"N/A","N/A","https://www.selleckchem.com/products/gallocatechin.html","C15H14O7","free base","(2S, 3R)-3, 4-Dihydro-2-(3, 4, 5-trihydroxyphenyl)-2H-1-benzopyran-3, 5, 7-triol; (2S-trans)-3, 4-Dihydro-2-(3, 4, 5-trihydroxyphenyl)-2H-1-benzopyran-3, 5, 7-triol; (-)-Gallocatechol; Gallocatechin","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S9055","Salvianolic acid A","h4","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.",494.45,"96574-01-5",{"v":10,"d":"10.00"},20.22,"N/A","N/A","https://www.selleckchem.com/products/salvianolic-acid-a.html","C26H22O10","free base","Dan Phenolic Acid A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)\\C=C\\C2=C(/C=C/C3=CC(=C(O)C=C3)O)C(=C(O)C=C2)O",4.209,3,6,9]
["S9057","Sinigrin","a5","L6400-07","in 10mM DMSO","Fungal,Immunology & Inflammation related","Microbiology","Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.",397.46,"3952-98-5",{"v":10,"d":"10.00"},25.16,"N/A","N/A","https://www.selleckchem.com/products/sinigrin.html","C10H16KNO9S2","free base","Allylglucosinolate, 2-Propenylglucosinolate","[K+].OCC1OC(S\\C(CC=C)=N\\O[S]([O-])(=O)=O)C(O)C(O)C1O",-3.447,3,4,7]
["S9061","Hydroxy safflor yellow A","b5","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.",612.53,"78281-02-4",{"v":10,"d":"10.00"},16.33,"N/A","N/A","https://www.selleckchem.com/products/hydroxy-safflor-yellow-a.html","C27H32O16","free base","2, 4-Di-b-D-glucopyranosyl-3, 4, 5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)-2, 5-cyclohexadien-1-one; Safflomin A","OCC1OC(C(O)C(O)C1O)C2=C(O)C(O)(C3OC(CO)C(O)C(O)C3O)C(=C(C(=O)\\C=C\\C4=CC=C(O)C=C4)C2=O)O",-4.096,4,11,7]
["S9069","Jatrorrhizine chloride","c5","L6400-07","in 10mM DMSO","AChR","Neuronal Signaling","Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.",373.83,"6681-15-8",{"v":10,"d":"10.00"},26.75,"N/A","N/A","https://www.selleckchem.com/products/jatrorrhizine-chloride.html","C20H20ClNO4","Chloride salt","Neprotine chloride, Yatrorhizine chloride","[Cl-].COC1=CC2=C(CC[N+]3=CC4=C(C=CC(=C4OC)OC)C=C23)C=C1O",1.262,3,1,3]
["S9070","Isoxanthohumol","d5","L6400-07","in 10mM DMSO","HSV","Microbiology","Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).",{"v":354.4,"d":"354.40"},"70872-29-6",{"v":10,"d":"10.00"},28.22,"N/A","N/A","https://www.selleckchem.com/products/isoxanthohumol.html","C21H22O5","free base","FI45719","COC1=CC(=C(CC=C(C)C)C2=C1C(=O)CC(O2)C3=CC=C(O)C=C3)O",4.456,3,2,4]
["S9071","Nootkatone","e5","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.",218.33,"4674-50-4","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/nootkatone.html","C15H22O","free base","N/A","CC1CC(=O)C=C2CCC(CC12C)C(C)=C",3.751,1,0,1]
["S9077","Plantamajoside","f5","L6400-07","in 10mM DMSO","Others","Others","Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential.",640.59,"104777-68-6",{"v":10,"d":"10.00"},15.61,"N/A","N/A","https://www.selleckchem.com/products/plantamajoside.html","C29H36O16","free base","Y0160, C10485","OCC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(CO)C2OC(=O)\\C=C\\C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",-0.404,6,10,12]
["S9084","Rhoifolin","g5","L6400-07","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.",578.52,"17306-46-6",{"v":10,"d":"10.00"},17.29,"N/A","N/A","https://www.selleckchem.com/products/rhoifolin.html","C27H30O14","free base","Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC4=C(C(=C3)O)C(=O)C=C(O4)C5=CC=C(O)C=C5)C(O)C(O)C1O",-0.378,6,8,6]
["S9085","Corynoline","h5","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.",{"v":367.4,"d":"367.40"},"18797-79-0",{"v":10,"d":"10.00"},27.22,"N/A","N/A","https://www.selleckchem.com/products/corynoline.html","C21H21NO5","free base","N/A","CN1CC2=C(C=CC3=C2OCO3)C4(C)C(O)CC5=C(C=C6OCOC6=C5)C14",2.732,4,1,0]
["S9088","Calycosin-7-O-beta-D-glucoside","a6","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.",{"v":446.4,"d":"446.40"},"20633-67-4",{"v":10,"d":"10.00"},{"v":22.4,"d":"22.40"},"N/A","N/A","https://www.selleckchem.com/products/calycosin-7-o-beta-d-glucoside.html","C22H22O10","free base","N/A","COC1=C(O)C=C(C=C1)C2=COC3=C(C=CC(=C3)OC4OC(CO)C(O)C(O)C4O)C2=O",0.436,5,5,5]
["S9089","Magnoflorine","b6","L6400-07","in 10mM DMSO","Tyrosinase","Proteases","Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.",342.41,"2141-09-5",{"v":10,"d":"10.00"},{"v":29.2,"d":"29.20"},"N/A","N/A","https://www.selleckchem.com/products/magnoflorine.html","C20H24NO4","free base","Escholin, Thalictrin","COC1=C(O)C2=C(CC3C4=C2C(=C(OC)C=C4CC[N+]3(C)C)O)C=C1",1.728,2,2,2]
["S9091","10-Gingerol","c6","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.",350.49,"23513-15-7",{"v":10,"d":"10.00"},28.53,"N/A","N/A","https://www.selleckchem.com/products/10-gingerol.html","C21H34O4","free base","N/A","CCCCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",5.463,2,2,14]
["S9094","Pogostone","d6","L6400-07","in 10mM DMSO","Anti-infection","Microbiology","Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.",224.25,"23800-56-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/pogostone.html","C12H16O4","free base","N/A","CC(C)CCC(=O)C1=C(O)C=C(C)OC1=O",1.821,3,1,4]
["S9095","Senegenin","e6","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.",537.13,"2469-34-3",{"v":10,"d":"10.00"},18.62,"N/A","N/A","https://www.selleckchem.com/products/senegenin.html","C30H45ClO6","free base","Tenuigenin","CC1(C)CCC2(CCC3=C(C(CCl)CC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O",{"v":4.91,"d":"4.910"},2,2,3]
["S9107","Glycitein","f6","L6400-07","in 10mM DMSO","ROS","Immunology & Inflammation","Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.",284.26,"40957-83-3",{"v":10,"d":"10.00"},35.18,"N/A","N/A","https://www.selleckchem.com/products/glycitein.html","C16H12O5","free base","N/A","COC1=CC2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O",2.366,3,2,2]
["S9112","Kaempferitrin","g6","L6400-07","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.",578.52,"482-38-2",{"v":100,"d":"100.00"},172.86,"N/A","N/A","https://www.selleckchem.com/products/kaempferitrin.html","C27H30O14","free base","Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside","CC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(O)C=C4)OC5OC(C)C(O)C(O)C5O)C(O)C(O)C1O",-0.211,6,8,5]
["S9120","Scutellarein","h6","L6400-07","in 10mM DMSO","Antiviral,Immunology & Inflammation related","Immunology & Inflammation","Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities",286.24,"529-53-3",{"v":57,"d":"57.00"},199.14,"N/A","N/A","https://www.selleckchem.com/products/scutellarein.html","C15H10O6","free base/salt","6-Hydroxyapigenin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)O",2.168,2,4,1]
["S9125","Apigetrin","a7","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.",432.38,"578-74-5",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/apigetrin.html","C21H20O10","free base","Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9127","Carnosol","b7","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.",330.42,"5957-80-2",{"v":66,"d":"66.00"},199.75,"N/A","N/A","https://www.selleckchem.com/products/carnosol.html","C20H26O4","free base","N/A","CC(C)C1=CC2=C(C(=C1O)O)C34CCCC(C)(C)C3CC2OC4=O",4.387,2,2,1]
["S9129","20(S)-Ginsenoside Rh1","c7","L6400-07","in 10mM DMSO","Immunology & Inflammation related,Interleukins,PPAR,TNF-alpha","Immunology & Inflammation","20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.",638.87,"63223-86-9",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/20-s-ginsenoside-rh1.html","C36H62O9","free base","Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(CC23C)OC5OC(CO)C(O)C(O)C5O",2.873,2,6,7]
["S9136","Neochlorogenic acid","d7","L6400-07","in 10mM DMSO","Antiviral,Bacterial,Immunology & Inflammation related","Immunology & Inflammation","Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.",354.31,"906-33-2",{"v":70,"d":"70.00"},197.57,"N/A","N/A","https://www.selleckchem.com/products/neochlorogenic-acid.html","C16H18O9","free base","Neochlorogenate, 5-O-Caffeoylquinic acid","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S9141","Berbamine","e7","L6400-07","in 10mM DMSO","Apoptosis related,Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",608.72,"478-61-5",{"v":100,"d":"100.00"},164.28,"N/A","N/A","https://www.selleckchem.com/products/berbamine.html","C37H40N2O6","free base","BA, BBM","COC1=C2OC3=C4C(CC5=CC=C(O)C(=C5)OC6=CC=C(CC7N(C)CCC(=C1)C7=C2)C=C6)N(C)CCC4=CC(=C3OC)OC",6.992,5,1,3]
["S9146","Anwuligan","f7","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.",{"v":328.4,"d":"328.40"},"107534-93-0",{"v":65,"d":"65.00"},197.93,"N/A","N/A","https://www.selleckchem.com/products/anwuligan.html","C20H24O4","free base","Macelignan","COC1=C(O)C=CC(=C1)CC(C)C(C)CC2=CC3=C(OCO3)C=C2",5.186,3,1,6]
["S9152","Epiberberine","g7","L6400-07","in 10mM DMSO","Others","Others","Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).",336.36,"6873-09-2",{"v":12,"d":"12.00"},35.68,"N/A","N/A","https://www.selleckchem.com/products/epiberberine.html","C20H18NO4","free base","N/A","COC1=C(OC)C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(OCO5)C4=C3",3.962,4,0,2]
["S9155","Aurantio-obtusin","h7","L6400-07","in 10mM DMSO","Others","Others","Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects.",330.29,"67979-25-3",{"v":66,"d":"66.00"},199.83,"N/A","N/A","https://www.selleckchem.com/products/aurantio-obtusin.html","C17H14O7","free base","N/A","COC1=C(O)C2=C(C=C1O)C(=O)C3=C(C2=O)C(=C(O)C(=C3)C)OC",2.535,4,3,2]
["S9163","Rhapontigenin","a8","L6400-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).",258.27,"500-65-2",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/rhapontigenin.html","C15H14O4","free base","Protigenin","COC1=CC=C(/C=C/C2=CC(=CC(=C2)O)O)C=C1O",3.073,1,3,3]
["S9174","Xanthotoxol","b8","L6400-07","in 10mM DMSO","5-HT Receptor,Immunology & Inflammation related","Neuronal Signaling","Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.",202.16,"2009-24-7",{"v":40,"d":"40.00"},197.86,"N/A","N/A","https://www.selleckchem.com/products/xanthotoxol.html","C11H6O4","free base","8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen","OC1=C2OC(=O)C=CC2=CC3=C1OC=C3",1.961,3,1,0]
["S9178","Sinapine thiocyanate","c8","L6400-07","in 10mM DMSO","Others","Immunology & Inflammation","Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.",368.45,"7431-77-8",{"v":73,"d":"73.00"},198.13,"N/A","N/A","https://www.selleckchem.com/products/sinapine-thiocyanate.html","C17H24N2O5S","free base","N/A","COC1=CC(=CC(=C1O)OC)/C=C/C(=O)OCC[N+](C)(C)C.[S-]C#N",1.287,4,1,8]
["S9184","Forsythoside B","d8","L6400-07","in 10mM DMSO","Immunology & Inflammation related,Interleukins,IκB/IKK,NF-κB,TNF-alpha","Immunology & Inflammation","Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.",{"v":756.7,"d":"756.70"},"81525-13-5",{"v":100,"d":"100.00"},132.15,"N/A","N/A","https://www.selleckchem.com/products/forsythoside-b.html","C34H44O19","free base","N/A","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(COC4OCC(O)(CO)C4O)C2OC(=O)/C=C/C5=CC(=C(O)C=C5)O)C(O)C(O)C1O",-0.925,8,10,14]
["S9186","Liensinine perchlorate","e8","L6400-07","in 10mM DMSO","Others","Others","Liensinine is the active constituent of plumula nelambinis with anti-hypertension.",{"v":711.2,"d":"711.20"},"2385-63-9",{"v":100,"d":"100.00"},140.61,"N/A","N/A","https://www.selleckchem.com/products/liensinine-perchlorate.html","C37H43ClN2O10","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2.O[Cl](=O)(=O)=O",7.345,4,2,9]
["S9188","Magnoflorine chloride","f8","L6400-07","in 10mM DMSO","Others","Others","Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities.",377.86,"6681-18-1",{"v":76,"d":"76.00"},201.13,"N/A","N/A","https://www.selleckchem.com/products/magnoflorinechloride.html","C20H24ClNO4","free base","Escholine chloride, Thalictrine chloride, Corytuberine methochloride","[Cl-].COC1=C(O)C2=C(CC3C4=C2C(=C(OC)C=C4CC[N+]3(C)C)O)C=C1",-0.946,2,2,2]
["S9189","Oroxin A","g8","L6400-07","in 10mM DMSO","PPAR","Metabolism","Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.",432.38,"57396-78-8",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-a.html","C21H20O10","free base","Baicalein 7-O-glucoside","OCC1OC(OC2=CC3=C(C(=O)C=C(O3)C4=CC=CC=C4)C(=C2O)O)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9190","Oroxin B","h8","L6400-07","in 10mM DMSO","Akt,Apoptosis related,COX,PI3K,PTEN","Apoptosis","Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.",594.52,"114482-86-9",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-b.html","C27H30O15","free base","Hypocretin-2","OCC1OC(OCC2OC(OC3=C(O)C(=C4C(=O)C=C(OC4=C3)C5=CC=CC=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.267,6,9,7]
["S9211","Eriocitrin","a9","L6400-07","in 10mM DMSO","Others","Others","Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.",596.53,"13463-28-0",{"v":100,"d":"100.00"},167.64,"N/A","N/A","https://www.selleckchem.com/products/eriocitrin.html","C27H32O15","free base","eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside","CC1OC(OCC2OC(OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C(=C5)O)O)C(O)C(O)C2O)C(O)C(O)C1O",-0.657,6,9,6]
["S9221","Ferulaldehyde","b9","L6400-07","in 10mM DMSO","Heme Oxygenase","Immunology & Inflammation","Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.",178.18,"458-36-6",{"v":35,"d":"35.00"},196.43,"N/A","N/A","https://www.selleckchem.com/products/ferulaldehyde.html","C10H10O3","free base","Coniferaldehyde, Ferulyl aldehyde","COC1=CC(=CC=C1O)\\C=C\\C=O",1.691,2,1,3]
["S9225","Santalol","c9","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.",220.35,"11031-45-1","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/santalol.html","C15H24O","free base","N/A","CC(\\CO)=C/CCC1(C)C2CCC(C2)C1=C",3.662,0,1,4]
["S9228","Schisandrin C","d9","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.",384.42,"61301-33-5",{"v":76.9,"d":"76.90"},200.04,"N/A","N/A","https://www.selleckchem.com/products/schisandrin-c.html","C22H24O6","free base","N/A","COC1=C2OCOC2=CC3=C1C4=C(CC(C)C(C)C3)C=C5OCOC5=C4OC",4.868,6,0,2]
["S9231","Schisanhenol","e9","L6400-07","in 10mM DMSO","Transferase","Metabolism","Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.",402.48,"69363-14-0",{"v":81,"d":"81.00"},201.25,"N/A","N/A","https://www.selleckchem.com/products/schisanhenol.html","C23H30O6","free base","Gomisin K3","COC1=C(OC)C(=C2C(=C1)CC(C)C(C)CC3=CC(=C(OC)C(=C23)OC)OC)O",5.041,5,1,5]
["S9234","Schaftoside","f9","L6400-07","in 10mM DMSO","Lipase,MyD88,TLR","Metabolism","Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.",564.49,"51938-32-0",{"v":100,"d":"100.00"},177.15,"N/A","N/A","https://www.selleckchem.com/products/schaftoside.html","C26H28O14","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC=C(O)C=C4)C(=C2O)C5OCC(O)C(O)C5O",-1.862,4,10,4]
["S9243","Protosappanin B","g9","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.",304.29,"102036-29-3",{"v":61,"d":"61.00"},200.46,"N/A","N/A","https://www.selleckchem.com/products/protosappanin-b.html","C16H16O6","free base","FT-0689654, Q-100961","OCC1(O)COC2=CC(=CC=C2C3=CC(=C(O)C=C3C1)O)O",1.486,1,4,1]
["S9250","Isosilybin","h9","L6400-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Isosilybin (Silymarin, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.",482.44,"72581-71-6",{"v":97,"d":"97.00"},201.06,"N/A","N/A","https://www.selleckchem.com/products/isosilybin.html","C25H22O10","free base","Silymarin, Isosilybinin, Q-100795","COC1=C(O)C=CC(=C1)C2OC3=C(OC2CO)C=C(C=C3)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S9259","Lithospermic acid","a10","L6400-07","in 10mM DMSO","Others","Others","Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects.",538.46,"28831-65-4",{"v":100,"d":"100.00"},185.72,"N/A","N/A","https://www.selleckchem.com/products/lithospermic-acid.html","C27H22O12","free base","N/A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=CC=C(O)C3=C2C(C(O3)C4=CC(=C(O)C=C4)O)C(O)=O",3.454,5,5,9]
["S9274","Isochlorogenic acid B","b10","L6400-07","in 10mM DMSO","Others","Others","Isochlorogenic acid B, naturally isolated from Laggera alata, has antioxidative and hepatoprotective properties.",516.45,"14534-61-3",{"v":100,"d":"100.00"},193.63,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-b.html","C25H24O12","free base","N/A","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,5,9]
["S9280","Demethoxycurcumin","c10","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.",338.35,"22608-11-3",{"v":68,"d":"68.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/demethoxycurcumin.html","C20H18O5","free base","N/A","COC1=CC(=CC=C1O)\\C=C\\C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",{"v":3.57,"d":"3.570"},3,2,7]
["S9282","Isochlorogenic acid A","d10","L6400-07","in 10mM DMSO","Others","Others","Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities.",516.45,"2450-53-5",{"v":100,"d":"100.00"},193.63,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-a.html","C25H24O12","free base","3,5-dicaffeoylquinic acid","OC1C(CC(O)(CC1OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C(O)=O)OC(=O)\\C=C\\C3=CC(=C(O)C=C3)O",1.687,5,5,9]
["S9293","Isoliquiritin","e10","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.",418.39,"5041-81-6",{"v":84,"d":"84.00"},200.77,"N/A","N/A","https://www.selleckchem.com/products/isoliquiritin.html","C21H22O9","free base","Neoisoliquritin","OCC1OC(OC2=CC=C(\\C=C\\C(=O)C3=C(O)C=C(O)C=C3)C=C2)C(O)C(O)C1O",1.046,3,6,6]
["S9298","Corylin","f10","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.",320.34,"53947-92-5",{"v":64,"d":"64.00"},199.79,"N/A","N/A","https://www.selleckchem.com/products/corylin.html","C20H16O4","free base","N/A","CC1(C)OC2=CC=C(C=C2C=C1)C3=COC4=CC(=CC=C4C3=O)O",3.412,3,1,1]
["S9299","Ginsenoside F1","g10","L6400-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Ginsenoside F1, a pharmaceutical component of ginseng, is known to have antiaging, antioxidant, anticancer, and keratinocyte protective effects. Ginsenoside F1 exhibits competitive inhibition of the activity of CYP3A4 with Ki values of 67.8 ± 16.2 μM. Ginsenoside F1 also exhibited a weaker inhibition of the activity of CYP2D6.",638.87,"53963-43-2",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/ginsenoside-f1.html","C36H62O9","free base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(O)CC34C",2.873,2,7,7]
["S9312","Cyanidin-3-O-glucoside chloride","h10","L6400-07","in 10mM DMSO","Others","Others","Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects.",484.84,"7084-24-4",{"v":97,"d":"97.00"},200.07,"N/A","N/A","https://www.selleckchem.com/products/cyanidin-3-o-glucoside-chloride.html","C21H21ClO11","free base","Kuromanin chloride, Chrysontemin chloride, Glucocyanidin chloride","[Cl-].OCC1OC(OC2=C([O+]=C3C=C(O)C=C(O)C3=C2)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",-1.566,2,8,4]
["S9318","(20R)-Ginsenoside Rh1","a11","L6400-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","(20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.",638.87,"80952-71-2",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rh1.html","C36H62O9","free base","N/A","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(CC23C)OC5OC(CO)C(O)C(O)C5O",2.873,2,6,7]
["S9319","Cryptochlorogenic acid","b11","L6400-07","in 10mM DMSO","Others","Others","Cryptochlorogenic acid (4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid), a phenolic acid found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, possesses antioxidant properties.",354.31,"905-99-7",{"v":71,"d":"71.00"},200.39,"N/A","N/A","https://www.selleckchem.com/products/cryptochlorogenic-acid.html","C16H18O9","free base","4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid","OC1CC(O)(CC(O)C1OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S9322","Neodiosmin","c11","L6400-07","in 10mM DMSO","Others","Others","Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.",608.54,"38665-01-9",{"v":100,"d":"100.00"},164.33,"N/A","N/A","https://www.selleckchem.com/products/neodiosmin.html","C28H32O15","free base","Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside","COC1=CC=C(C=C1O)C2=CC(=O)C3=C(O2)C=C(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)C=C3O",-0.395,7,8,7]
["S9329","Orcinol","d11","L6400-07","in 10mM DMSO","Others","Others","Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects.",124.14,"504-15-4",{"v":24,"d":"24.00"},193.33,"N/A","N/A","https://www.selleckchem.com/products/orcinol.html","C7H8O2","free base","5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene","CC1=CC(=CC(=C1)O)O",1.832,0,2,0]
["S9338","Octyl gallate","e11","L6400-07","in 10mM DMSO","Others","Microbiology","Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.",282.33,"1034-01-1",{"v":56,"d":"56.00"},198.35,"N/A","N/A","https://www.selleckchem.com/products/octyl-gallate.html","C15H22O5","free base","Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester","CCCCCCCCOC(=O)C1=CC(=C(O)C(=C1)O)O",4.112,2,3,9]
["S9341","3,4-Dimethoxycinnamic acid","f11","L6400-07","in 10mM DMSO","Anti-infection","Microbiology","3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.",208.21,"2316-26-9",{"v":42,"d":"42.00"},201.72,"N/A","N/A","https://www.selleckchem.com/products/3-4-dimethoxycinnamic-acid.html","C11H12O4","free base","Caffeic acid dimethyl ether","COC1=CC=C(/C=C/C(O)=O)C=C1OC",1.894,3,0,4]
["S9355","2,4'-Dihydroxybenzophenone","g11","L6400-07","in 10mM DMSO","Others","Others","2,4'-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents.",214.22,"606-12-2",{"v":43,"d":"43.00"},200.73,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/2-4-dihydroxybenzophenone.html","C13H10O3","Free Base","N/A","OC1=CC=C(C=C1)C(=O)C2=CC=CC=C2O",{"v":2.75,"d":"2.750"},1,2,2]
["S9378","4',5-Dihydroxyflavone","h11","L6400-07","in 10mM DMSO","Carbohydrate Metabolism,Lipoxygenase","Metabolism","4',5-Dihydroxyflavone inhibits soybean  LOX-1 and yeast α-glucosidase.",254.24,"6665-67-4",{"v":50,"d":"50.00"},196.67,"N/A","N/A","https://www.selleckchem.com/products/4-5-ihydroxyflavone.html","C15H10O4","free base","N/A","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC=C3O",2.652,2,2,1]
["S9384","Sophocarpine Monohydrate","a2","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.",264.36,"145572-44-7",{"v":52,"d":"52.00"},{"v":196.7,"d":"196.70"},"N/A","N/A","https://www.selleckchem.com/products/sophocarpine-monohydrate.html","C15H24N2O2","free base","N/A","O.O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.187,1,0,0]
["S9397","Alliin","b2","L6400-08","in 10mM DMSO","Others","Others","Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.",177.22,"556-27-4",{"v":3,"d":"3.00"},16.93,"N/A","N/A","https://www.selleckchem.com/products/alliin.html","C6H11NO3S","free base","S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine","NC(C[S](=O)CC=C)C(O)=O",-3.391,2,1,5]
["S9399","1,2,3,4,6-O-Pentagalloylglucose","c2","L6400-08","in 10mM DMSO","Others","Others","1,2,3,4,6-O-Pentagalloylglucose is the pentagallic acid ester of glucose. It could be used for precipitating proteins.",940.68,"14937-32-7",{"v":100,"d":"100.00"},106.31,"N/A","N/A","https://www.selleckchem.com/products/o-pentagalloylglucose.html","C41H32O26","free base","N/A","OC1=C(O)C(=CC(=C1)C(=O)OCC2OC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(OC(=O)C4=CC(=C(O)C(=C4)O)O)C(OC(=O)C5=CC(=C(O)C(=C5)O)O)C2OC(=O)C6=CC(=C(O)C(=C6)O)O)O",4.073,11,15,16]
["S9401","3,6'-Disinapoyl sucrose","d2","L6400-08","in 10mM DMSO","Others","Others","3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.",754.69,"139891-98-8",{"v":100,"d":"100.00"},132.51,"N/A","N/A","https://www.selleckchem.com/products/3-6-disinapoyl-sucrose.html","C34H42O19","free base","Disinapoyl sucrose","COC1=CC(=CC(=C1O)OC)\\C=C\\C(=O)OCC2OC(OC3(CO)OC(CO)C(O)C3OC(=O)/C=C/C4=CC(=C(O)C(=C4)OC)OC)C(O)C(O)C2O",0.162,11,8,17]
["S9403","Ecliptasaponin A","e2","L6400-08","in 10mM DMSO","Others","Others","Ecliptasaponin A, a natural triterpenoid glucoside, has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition.",634.84,"78285-90-2",{"v":100,"d":"100.00"},157.52,"N/A","N/A","https://www.selleckchem.com/products/ecliptasaponin-a.html","C36H58O9","free base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1)C(O)=O",3.598,3,5,4]
["S9407","Angoroside C","f2","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.",784.75,"115909-22-3",{"v":100,"d":"100.00"},127.43,"N/A","N/A","https://www.selleckchem.com/products/angoroside-c.html","C36H48O19","free base","N/A","COC1=CC=C(CCOC2OC(COC3OCC(O)C(O)C3O)C(OC(=O)/C=C/C4=CC=C(O)C(=C4)OC)C(OC5OC(C)C(O)C(O)C5O)C2O)C=C1O",-0.301,10,9,15]
["S9411","Liensinine","g2","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"2586-96-1",{"v":100,"d":"100.00"},163.74,"N/A","N/A","https://www.selleckchem.com/products/liensinine.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9417","Homoplantaginin","h2","L6400-08","in 10mM DMSO","Immunology & Inflammation related,Interleukins,IκB/IKK,NF-κB,TNF-alpha","Immunology & Inflammation","Homoplantaginin (Hispidulin-7-glucoside), a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin inhibits TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.",{"v":462.4,"d":"462.40"},"17680-84-1",{"v":92,"d":"92.00"},198.96,"N/A","N/A","https://www.selleckchem.com/products/homoplantaginin.html","C22H22O11","free base","Hispidulin-7-glucoside","COC1=C(OC2OC(CO)C(O)C(O)C2O)C=C3OC(=CC(=O)C3=C1O)C4=CC=C(O)C=C4",0.464,5,6,5]
["S9418","Parishin B","a3","L6400-08","in 10mM DMSO","Others","Others","Parishin B is a dominant active ingredient originating from Gastrodia elata Blume, and has good neuroprotective effects against brain disorders.",728.65,"174972-79-3",{"v":100,"d":"100.00"},137.24,"N/A","N/A","https://www.selleckchem.com/products/parishin-b.html","C32H40O19","free base","N/A","OCC1OC(OC2=CC=C(COC(=O)CC(O)(CC(O)=O)C(=O)OCC3=CC=C(OC4OC(CO)C(O)C(O)C4O)C=C3)C=C2)C(O)C(O)C1O",-2.045,9,8,17]
["S9423","Narcissoside","b3","L6400-08","in 10mM DMSO","Others","Others","Narcissoside has antioxidant and antiproliferative activity in cancer.",624.54,"604-80-8",{"v":100,"d":"100.00"},160.12,"N/A","N/A","https://www.selleckchem.com/products/narcissoside.html","C28H32O16","free base","N/A","COC1=C(O)C=CC(=C1)C2=C(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)C(=O)C5=C(O)C=C(O)C=C5O2",-0.933,7,9,7]
["S9424","Liensinine diperchlorate","c3","L6400-08","in 10mM DMSO","Autophagy,Mitophagy","Autophagy","Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.",811.66,"5088-90-4",{"v":50,"d":"50.00"},{"v":61.6,"d":"61.60"},"N/A","N/A","https://www.selleckchem.com/products/liensinine-diperchlorate.html","C37H44Cl2N2O14","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC(=C(O)C=C3)OC4=C(OC)C=C5CCN(C)C(CC6=CC=C(O)C=C6)C5=C4)N(C)CC2.O[Cl](=O)(=O)=O.O[Cl](=O)(=O)=O",7.669,4,2,9]
["S9428","Brazilin","d3","L6400-08","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.",286.28,"474-07-7",{"v":57,"d":"57.00"},199.11,"N/A","N/A","https://www.selleckchem.com/products/brazilin.html","C16H14O5","free base","Natural Red 24","OC1=CC2=C(C=C1)C3C4=CC(=C(O)C=C4CC3(O)CO2)O",1.933,1,3,0]
["S9434","8-Gingerol","e3","L6400-08","in 10mM DMSO","Others","Others","8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect.",322.44,"23513-08-8",{"v":64,"d":"64.00"},198.49,"N/A","N/A","https://www.selleckchem.com/products/8-gingerol.html","C19H30O4","free base","N/A","CCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",4.551,2,2,12]
["S9437","Echinatin","f3","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.",270.28,"34221-41-5",{"v":54,"d":"54.00"},199.79,"N/A","N/A","https://www.selleckchem.com/products/echinatin.html","C16H14O4","free base","N/A","COC1=CC(=CC=C1\\C=C\\C(=O)C2=CC=C(O)C=C2)O",3.201,2,2,4]
["S9440","Naringenin chalcone","g3","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.",272.25,"73692-50-9",{"v":54,"d":"54.00"},198.35,"N/A","N/A","https://www.selleckchem.com/products/naringenin-chalcone.html","C15H12O5","free base","Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone","OC1=CC=C(C=C1)/C=C/C(=O)C2=C(O)C=C(O)C=C2O",2.734,1,4,3]
["S9441","Sibiricose A5","h3","L6400-08","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity., Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity.",518.47,"107912-97-0",{"v":100,"d":"100.00"},192.88,"N/A","N/A","https://www.selleckchem.com/products/sibiricose-a5.html","C22H30O14","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2C(O)C(CO)OC2(CO)OC3OC(CO)C(O)C(O)C3O",-2.058,6,8,10]
["S9455","Isorhamnetin 3-O-neohesperoside","a4","L6400-08","in 10mM DMSO","Others","Metabolism","Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has signiﬁcant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.",624.54,"55033-90-4",{"v":100,"d":"100.00"},160.12,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/isorhamnetin-3-o-neohesperoside.html","C28H32O16","Free Base","N/A","COC1=CC(=CC=C1O)C2=C(OC3OC(CO)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C(=O)C5=C(O2)C=C(O)C=C5O",-0.933,7,9,7]
["S9473","Nuzhenide","b4","L6400-08","in 10mM DMSO","Others","Others","Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity.",686.66,"39011-92-2",{"v":100,"d":"100.00"},145.63,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/nuzhenide.html","C31H42O17","Free Base","Specnuezhenide","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C\\C)C1CC(=O)OCC3OC(OCCC4=CC=C(O)C=C4)C(O)C(O)C3O",-1.339,9,8,14]
["S9487","Praeruptorin C","c4","L6400-08","in 10mM DMSO","Others","Others","Praeruptorin C is a natural compound derived from the dried roots of Peucedanum praeruptorum and has beneficial effects in suppressing osteoclast formation and resorption function. It is frequently utilized in traditional Chinese medicine for treating upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent.",428.47,"72463-77-5",{"v":86,"d":"86.00"},200.71,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/praeruptorin-c.html","C24H28O7","Free Base","N/A","C\\C=C(C)/C(=O)OC1C(OC(=O)CC(C)C)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3",4.877,7,0,7]
["S9502","Madecassic acid","d4","L6400-08","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.",{"v":504.7,"d":"504.70"},"18449-41-7",{"v":100,"d":"100.00"},198.13,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/madecassic-acid.html","C30H48O6","Free Base","Brahmic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(O)=O",3.265,1,4,2]
["S9503","Fraxetin","e4","L6400-08","in 10mM DMSO","Heme Oxygenase","Apoptosis","Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.",208.17,"574-84-5",{"v":42,"d":"42.00"},201.76,"N/A","N/A","https://www.selleckchem.com/products/fraxetin.html","C10H8O5","free base","7,8-dihydroxy-6-methoxy coumarin","COC1=CC2=C(OC(=O)C=C2)C(=C1O)O","N/A","N/A","N/A","N/A"]
["S9552","Farrerol","f4","L6400-08","in 10mM DMSO","Others","Immunology & Inflammation","Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.",300.31,"24211-30-1",{"v":60,"d":"60.00"},199.79,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/farrerol.html","C17H16O5","Free Base","N/A","CC1=C(O)C2=C(OC(CC2=O)C3=CC=C(O)C=C3)C(=C1O)C",3.346,2,3,1]
["S6563","DMNQ","g4","L6400-08","in 10mM DMSO","Others","Others","DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.",218.21,"6956-96-3",{"v":44,"d":"44.00"},201.64,"<1","N/A","http://www.selleck.cn/products/dmnq.html","C12H10O4","Free Base","N/A","COC1=C(OC)C(=O)C2=C(C=CC=C2)C1=O",1.133,4,0,2]
["S6626","Brequinar (DUP785)","h4","L6400-08","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.",375.37,"96187-53-0",{"v":37,"d":"37.00"},98.57,"<1","N/A","http://www.selleck.cn/products/brequinar.html","C23H15F2NO2","Free Base","NSC 368390","CC1=C(N=C2C=CC(=CC2=C1C(O)=O)F)C3=CC=C(C=C3)C4=C(F)C=CC=C4",6.008,2,0,3]
["S6744","Inauhzin","a5","L6400-08","in 10mM DMSO","Sirtuin","Epigenetics","Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.",469.58,"309271-94-1",{"v":94,"d":"94.00"},200.18,"<1","N/A","http://www.selleck.cn/products/inauhzin.html","C25H19N5OS2","Free Base","N/A","CCC(SC1=NN=C2C(=N1)[NH]C3=C2C=CC=C3)C(=O)N4C5=C(SC6=CC=CC=C46)C=CC=C5",6.482,4,1,4]
["S6752","Y16","b5","L6400-08","in 10mM DMSO","Rho","Cell Cycle","Y16 is an inhibitor of G-protein-coupled Rho GEFs. It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM).",384.43,"429653-73-6",{"v":39,"d":"39.00"},101.45,"<1","N/A","http://www.selleck.cn/products/y16.html","C24H20N2O3","Free Base","N/A","CC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=C/3C(=O)NN(C3=O)C4=CC=CC=C4",4.305,3,1,5]
["S8877","Imidazole ketone erastin (PUN30119)","c5","L6400-08","in 10mM DMSO","Ferroptosis","Metabolism","Imidazole ketone erastin (PUN30119, IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis.",655.14,"1801530-11-9",{"v":100,"d":"100.00"},152.64,"<1","N/A","http://www.selleck.cn/products/imidazole-ketone-erastin.html","C35H35ClN6O5","Free Base","IKE","CC(C)OC1=CC=C(C=C1N2C(=NC3=CC=CC=C3C2=O)CN4CCN(CC4)C(=O)COC5=CC=C(Cl)C=C5)C(=O)C[N]6C=CN=C6",4.057,7,0,11]
["S9024","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)","d5","L6400-08","in 10mM DMSO","Lipoxygenase","Metabolism","3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.",512.72,"67416-61-9",{"v":100,"d":"100.00"},195.04,"N/A","N/A","https://www.selleckchem.com/products/akba.html","C32H48O5","Salt","FA42758","CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C",6.081,4,0,3]
["S9050","Boldine","e5","L6400-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.",327.37,"476-70-0",{"v":10,"d":"10.00"},30.55,"N/A","N/A","https://www.selleckchem.com/products/boldine.html","C19H21NO4","free base","1, 10-Dimethoxy-2, 9-dihydroxyaporphine; ex Peumus boldus","COC1=C(O)C=C2CC3N(C)CCC4=CC(=C(OC)C(=C34)C2=C1)O",3.083,2,2,2]
["S9102","Magnolin","f5","L6400-08","in 10mM DMSO","ERK","MAPK","Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).",416.46,"31008-18-1",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/magnolin.html","C23H28O7","free Base","N/A","COC1=C(OC)C=C(C=C1)C2OCC3C2COC3C4=CC(=C(OC)C(=C4)OC)OC",2.618,7,0,7]
["S9110","Morin","g5","L6400-08","in 10mM DMSO","Others","Others","Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.",302.24,"480-16-0",{"v":10,"d":"10.00"},33.09,"N/A","N/A","https://www.selleckchem.com/products/morin.html","C15H10O7","free base","Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum","OC1=CC(=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S9111","Isorhamnetin","h5","L6400-08","in 10mM DMSO","Tyrosinase","Proteases","Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.",316.26,"480-19-3",{"v":63,"d":"63.00"},{"v":199.2,"d":"199.20"},"N/A","N/A","https://www.selleckchem.com/products/isorhamnetin.html","C16H12O7","free base","3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol","COC1=C(O)C=CC(=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",1.856,3,4,2]
["S9123","Eriodictyol","a6","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.",288.25,"552-58-9",{"v":57,"d":"57.00"},197.74,"N/A","N/A","https://www.selleckchem.com/products/eriodictyol.html","C15H12O6","free base","N/A","OC1=CC2=C(C(=O)CC(O2)C3=CC(=C(O)C=C3)O)C(=C1)O",2.131,2,4,1]
["S9192","Vitexin","b6","L6400-08","in 10mM DMSO","Others","Others","Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.",432.38,"3681-93-4",{"v":47,"d":"47.00"},{"v":108.7,"d":"108.70"},"N/A","N/A","https://www.selleckchem.com/products/vitexin.html","C21H20O10","free base","Apigenin-8-C-glucoside","OCC1OC(C(O)C(O)C1O)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=CC=C(O)C=C4",0.018,3,7,3]
["S9248","Homoorientin","c6","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent.",448.38,"4261-42-1",{"v":90,"d":"90.00"},200.72,"N/A","N/A","https://www.selleckchem.com/products/homoorientin.html","C21H20O11","free Base","Isoorientin, Luteolin-6-C-glucoside","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC(=C(O)C=C4)O)C=C2O",-0.224,3,8,3]
["S9288","Casticin","d6","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.",374.34,"479-91-4",{"v":75,"d":"75.00"},200.35,"N/A","N/A","https://www.selleckchem.com/products/casticin.html","C19H18O8","free base","Vitexicarpin","COC1=C(O)C=C(C=C1)C2=C(OC)C(=O)C3=C(O2)C=C(OC)C(=C3O)OC",2.291,6,2,5]
["S2009","Indirubin-3'-monoxime","e6","L6400-08","in 10mM DMSO","CDK","Cell Cycle","Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.",277.28,"160807-49-8",{"v":55,"d":"55.00"},198.36,"<1","N/A","http://www.selleck.cn/products/indirubin-3-monoxime.html","C16H11N3O2","Free Base","Indirubin-3'-oxime","O/N=C1/C(NC2=C1C=CC=C2)=C3\\C(=O)NC4=C3C=CC=C4",1.943,2,2,0]
["S6647","Bardoxolone","f6","L6400-08","in 10mM DMSO","Nrf2","Immunology & Inflammation","Bardoxolone (CDDO, RTA 401), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2  that induce programmed cell death (apoptosis) in cancer cells.",491.66,"218600-44-3",{"v":6,"d":"6.00"},{"v":12.2,"d":"12.20"},"<1","N/A","http://www.selleck.cn/products/bardoxolone.html","C31H41NO4","Free Base","CDDO, RTA 401","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C5(C)C=C(C#N)C(=O)C(C)(C)C5CCC34C)C(O)=O",5.573,3,0,1]
["S6656","VAS2870","g6","L6400-08","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.",360.39,"722456-31-7",{"v":36,"d":"36.00"},99.89,"<1","N/A","http://www.selleck.cn/products/vas2870.html","C18H12N6OS","Free Base","N/A","C([N]1N=NC2=C1N=CN=C2SC3=NC4=C(O3)C=CC=C4)C5=CC=CC=C5",4.369,6,0,4]
["S6673","CCG-222740","h6","L6400-08","in 10mM DMSO","Actin,Rho","Cell Cycle","CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.",444.86,"1922098-69-8",{"v":89,"d":"89.00"},200.06,"<1","N/A","http://www.selleck.cn/products/ccg-222740.html","C23H19ClF2N2O3","Free Base","N/A","FC1(F)CC(CN(C1)C(=O)C2=CC(=CC=C2)C3=CC=CO3)C(=O)NC4=CC=C(Cl)C=C4",{"v":3.99,"d":"3.990"},3,1,4]
["S6680","L-779450","a7","L6400-08","in 10mM DMSO","Raf","MAPK","L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM.",{"v":347.8,"d":"347.80"},"303727-31-3",{"v":70,"d":"70.00"},201.27,"<1","N/A","http://www.selleck.cn/products/l-779450.html","C20H14ClN3O","Free Base","L-779,450","OC1=CC(=CC=C1Cl)C2=C(N=C([NH]2)C3=CC=CC=C3)C4=CC=NC=C4",{"v":4.67,"d":"4.670"},2,2,3]
["S9235","Didymin","b7","L6400-08","in 10mM DMSO","p53","Apoptosis","Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.",594.56,"14259-47-3",{"v":100,"d":"100.00"},168.19,{"v":100,"d":"100.00"},168.19,"http://www.selleck.cn/products/didymin.html","C28H34O14","Free Base","Neoponcirin, Isosakuranetin-7-O-rutinoside","COC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O",-0.189,7,7,7]
["S2121","Licofelone (ML3000)","c7","L6400-08","in 10mM DMSO","COX","Neuronal Signaling","Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.",379.88,"156897-06-2",{"v":19,"d":"19.00"},50.02,"<1","N/A","http://www.selleckchem.com/products/licofelone.html","C23H22ClNO2","Free Base","ML3000","CC1(C)C[N]2C(=C(C3=CC=C(Cl)C=C3)C(=C2C1)C4=CC=CC=C4)CC(O)=O",{"v":5.78,"d":"5.780"},1,0,4]
["S2427","Triglycidyl Isocyanurate (Teroxirone)","d7","L6400-08","in 10mM DMSO","DNA/RNA Synthesis,p53","Apoptosis","Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.",297.26,"2451-62-9",{"v":59,"d":"59.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/triglycidyl-isocyanurat.html","C12H15N3O6","Free Base","Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC","O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4",-0.894,6,0,6]
["S0023","K-Ras-IN-1","e7","L6400-08","in 10mM DMSO","Ras","Cell Cycle","K-Ras-IN-1 (MDK-3017) inhibits K-Ras by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.",207.29,"84783-01-7",{"v":41,"d":"41.00"},197.79,"<1","N/A","http://www.selleckchem.com/products/k-ras-in-1.html","C11H13NOS","free base","MDK-3017","OC1=CC=CC=C1C(=S)N2CCCC2",2.886,0,1,2]
["S0178","GLX351322","f7","L6400-08","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.",431.51,"835598-94-2",{"v":20,"d":"20.00"},46.35,"<1","N/A","http://www.selleckchem.com/products/glx351322.html","C21H25N3O5S","free base","N/A","CCOC(=O)C1=C(NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3)SC4=C1CCC4",{"v":2.15,"d":"2.150"},5,1,7]
["S0507","CBL0137","g7","L6400-08","in 10mM DMSO","NF-κB,p53","NF-κB","CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.",336.43,"1197996-80-7",{"v":15,"d":"15.00"},44.59,"<1","N/A","http://www.selleckchem.com/products/cbl-0137.html","C21H24N2O2","free base","Curaxin-137, CBL-C137, CBLC137","CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",3.338,2,1,6]
["S2176","Tenovin-3","h7","L6400-08","in 10mM DMSO","p53,Sirtuin","DNA Damage/DNA Repair","Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.",327.44,"1011301-27-1",{"v":65,"d":"65.00"},198.51,"<1","N/A","http://www.selleckchem.com/products/tenovin-3.html","C18H21N3OS","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(N)C=C2",{"v":4.42,"d":"4.420"},1,3,5]
["S3205","Perillaldehyde","a8","L6400-08","in 10mM DMSO","AhR,CCR,Nrf2,ROS","Metabolism","Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.",150.22,"18031-40-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/perillaldehyde.html","C10H14O","free base","Perilladehyde, Perillal, PAE, PA","CC(=C)C1CCC(=CC1)C=O",2.668,1,0,2]
["S3220","Trigonelline","b8","L6400-08","in 10mM DMSO","Akt,Anti-infection,Microtubule Associated,Phospholipase (e.g. PLA),PI3K","Metabolism","Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.",137.14,"535-83-1",{"v":50,"d":"50.00"},364.59,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/trigonelline.html","C7H7NO2","free base","Trigenolline","C[N+]1=CC(=CC=C1)C([O-])=O",{"v":-0.41,"d":"-0.410"},0,0,1]
["S3222","Raspberry ketone glucoside","c8","L6400-08","in 10mM DMSO","ROS","Immunology & Inflammation","Raspberry ketone glucoside (RKG), a natural product in raspberry fruit,  is an antioxidant that has the inhibitory effect on the melanin synthesis.",326.34,"38963-94-9",{"v":100,"d":"100.00"},306.43,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/raspberry-ketone-glucoside.html","C16H22O7","free base","RKG","CC(=O)CCC1=CC=C(OC2OC(CO)C(O)C(O)C2O)C=C1",-0.121,3,4,6]
["S3235","Sinapine","d8","L6400-08","in 10mM DMSO","P-gp","Transmembrane Transporters","Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.",310.36,"18696-26-9",{"v":100,"d":"100.00"},322.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/sinapine.html","C16H24NO5","free base","N/A","COC1=C(O)C(=CC(=C1)\\C=C\\C(=O)OCC[N+](C)(C)C)OC",0.662,4,1,8]
["S3238","Resibufogenin","e8","L6400-08","in 10mM DMSO","Akt,Apoptosis related,Bcl-2,Caspase,CDK,GSK-3,Mixed Lineage Kinase,PI3K,RIP kinase,ROS,Wnt/beta-catenin","Apoptosis","Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.",384.51,"465-39-4",{"v":100,"d":"100.00"},260.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/resibufogenin.html","C24H32O4","free base","Bufogenin, Recibufogenin","CC12CCC(O)CC1CCC3C2CCC4(C)C(CC5OC345)C6=COC(=O)C=C6",3.113,3,1,1]
["S3255","Pectolinarigenin","f8","L6400-08","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).",314.29,"520-12-7",{"v":100,"d":"100.00"},318.18,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/pectolinarigenin.html","C17H14O6","free base","N/A","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O)C(=C(O)C=C3O2)OC",2.619,4,2,3]
["S3275","Senkyunolide I","g8","L6400-08","in 10mM DMSO","Apoptosis related,Bcl-2,Caspase,ERK,Nrf2","MAPK","Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic,  anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.",224.25,"94596-28-8",{"v":100,"d":"100.00"},445.93,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/senkyunolide-i.html","C12H16O4","free base","SEI, SENI","CCC\\C=C1/OC(=O)C2=C1CCC(O)C2O",1.316,2,2,2]
["S3301","Cynarin","h8","L6400-08","in 10mM DMSO","CD markers,Glutathione,Nrf2,ROS","Immunology & Inflammation","Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.",516.45,"30964-13-7",{"v":100,"d":"100.00"},193.63,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cynarin.html","C25H24O12","free base","Cynarine","OC1CC(CC(OC(=O)/C=C/C2=CC=C(O)C(=C2)O)C1O)(OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,6,9]
["S6851","RA-190","a9","L6400-08","in 10mM DMSO","Autophagy,p53,Proteasome","Ubiquitin","RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.",596.76,"1617495-03-0",{"v":100,"d":"100.00"},167.57,"<1","N/A","http://www.selleckchem.com/products/ra-190.html","C28H23Cl5N2O2","free base","N/A","Cl.NC(CC1=CC=CC=C1)C(=O)N2CC(=C/C3=CC(=C(Cl)C=C3)Cl)/C(=O)C(/C2)=C\\C4=CC(=C(Cl)C=C4)Cl",7.285,2,1,5]
["S6882","HI-TOPK-032","b9","L6400-08","in 10mM DMSO","Apoptosis related,Caspase,ERK,p53,PARP,TOPK","MAPK","HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.",{"v":369.4,"d":"369.40"},"487020-03-1",{"v":4,"d":"4.00"},10.83,"<1","N/A","http://www.selleckchem.com/products/hi-topk-032.html","C20H11N5OS","free base","N/A","O=C(NC1=CC2=C(C#N)C3=C(N=C4C=CC=CC4=N3)[N]2C=C1)C5=CC=CS5",3.567,3,1,2]
["S6905","MCP110","c9","L6400-08","in 10mM DMSO","Raf,Ras","MAPK","MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.",508.65,"521310-51-0",{"v":100,"d":"100.00"},{"v":196.6,"d":"196.60"},"<1","N/A","http://www.selleckchem.com/products/mcp110.html","C33H36N2O3","free base","N/A","COC1=CC(=CC=C1OCC2=CC=CC=C2)CN(CCC3=NC=CC=C3)C(=O)CCCCC4=CC=CC=C4",6.677,4,0,14]
["S8916","BI-3406","d9","L6400-08","in 10mM DMSO","Ras","Cell Cycle","BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhibits anti-tumor activities.",462.46,"2230836-55-0",{"v":92,"d":"92.00"},198.94,"<1","N/A","http://www.selleckchem.com/products/bi-3406.html","C23H25F3N4O3","free base","N/A","COC1=C(OC2CCOC2)C=C3C(=NC(=NC3=C1)C)NC(C)C4=CC(=CC(=C4)N)C(F)(F)F",3.594,5,2,7]
["S8974","GSK2795039","e9","L6400-08","in 10mM DMSO","Apoptosis related,NADPH-oxidase,ROS","Immunology & Inflammation","GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.",450.56,"1415925-18-6",{"v":90,"d":"90.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/gsk2795039.html","C23H26N6O2S","free base","N/A","CC(C)[N]1C=C(C2=CC=C3CCN(C)C3=C2)C4=C1N=CC=C4N[S](=O)(=O)C5=N[N](C)C=C5",3.536,4,1,5]
["S8978","Mitoquinone (MitoQ10) mesylate","f9","L6400-08","in 10mM DMSO","ROS","Immunology & Inflammation","Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.",678.81,"845959-50-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/mitoquinone-mesylate.html","C38H47O7PS","mesylate","MitoQ, Mitoubiquinone","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.C[S]([O-])(=O)=O",6.675,4,0,16]
["S9611","ABTL-0812","g9","L6400-08","in 10mM DMSO","Akt,Autophagy,mTOR,ROS","PI3K/Akt/mTOR","ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.",296.44,"57818-44-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/abtl-0812.html","C18H32O3","free base","α-Hydroxylinoleic acid","CCCCC\\C=C/C\\C=C/CCCCCCC(O)C(O)=O",5.629,1,1,14]
["S9687","H2DCFDA","h9","L6400-08","in 10mM DMSO","ROS","Immunology & Inflammation","H2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production.",487.29,"4091-99-0",{"v":97,"d":"97.00"},199.06,{"v":97,"d":"97.00"},199.06,"http://www.selleckchem.com/products/h2dcfda.html","C24H16Cl2O7","free base","DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate","CC(=O)OC1=CC2=C(C=C1Cl)C(C3=C(O2)C=C(OC(C)=O)C(=C3)Cl)C4=C(C=CC=C4)C(O)=O",5.312,6,0,6]
["S0056","(E/Z)-BCI","a10","L6400-08","in 10mM DMSO","Apoptosis related,phosphatase,ROS","Metabolism","(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.",317.42,"15982-84-0",{"v":63,"d":"63.00"},198.48,"<1","N/A","https://www.selleckchem.com/products/dual-specificity-protein-phosphatase-1-6-Inhibitor-bcl.html","C22H23NO","Free Base","BCI, NSC 150117","O=C1\\C(=C/C2=CC=CC=C2)C(NC3CCCCC3)C4=CC=CC=C14",{"v":4.84,"d":"4.840"},1,1,3]
["S0323","Antineoplaston A10","b10","L6400-08","in 10mM DMSO","Ras","Apoptosis","Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.",246.26,"91531-30-5",{"v":49,"d":"49.00"},198.98,"<1","N/A","https://www.selleckchem.com/products/antineoplaston-a10.html","C13H14N2O3","Free Base","N/A","O=C1CCC(NC(=O)CC2=CC=CC=C2)C(=O)N1",0.307,3,2,3]
["S0759","FPL 62064","c10","L6400-08","in 10mM DMSO","COX,Lipoxygenase","Metabolism","FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.",265.31,"103141-09-9",{"v":53,"d":"53.00"},199.77,"<1","N/A","https://www.selleckchem.com/products/fpl-62064.html","C16H15N3O","Free Base","N/A","COC1=CC=C(NC2=N[N](C=C2)C3=CC=CC=C3)C=C1",4.129,2,1,4]
["S0780","Oncrasin-1","d10","L6400-08","in 10mM DMSO","DNA/RNA Synthesis,PKC","Cell Cycle","Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.",269.73,"75629-57-1",{"v":54,"d":"54.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/oncrasin-1.html","C16H12ClNO","Free Base","N/A","ClC1=CC=C(C[N]2C=C(C=O)C3=C2C=CC=C3)C=C1",4.336,1,0,3]
["S0890","MLS000532223","e10","L6400-08","in 10mM DMSO","Rho","Cell Cycle","MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM.",251.24,"16616-39-0",{"v":50,"d":"50.00"},199.01,"<1","N/A","https://www.selleckchem.com/products/mls000532223.html","C15H9NO3","Free Base","N/A","[O-][N+](=O)C1=CC=CC(=C1)C(=O)C#CC2=CC=CC=C2",3.719,1,0,4]
["S3357","Elaidic acid","f10","L6400-08","in 10mM DMSO","Apoptosis related,ROS","Apoptosis","Elaidic acid is a major trans fatty acid that inhibits cell viability, elevates cell apoptosis by enhancing oxidative stress. Elaidic acid can be used as a pharmaceutical solvent.",282.46,"112-79-8",{"v":56,"d":"56.00"},198.26,"<1","N/A","https://www.selleckchem.com/products/elaidic-acid.html","C18H34O2","Free Base","N/A","CCCCCCCC\\C=C\\CCCCCCCC(O)=O",{"v":6.86,"d":"6.860"},1,0,15]
["S5645","Hemin","g10","L6400-08","in 10mM DMSO","Heme Oxygenase","Apoptosis","Hemin (protohemin) is an iron-containing porphyrin used in the management of porphyria attacks, particularly in acute intermittent porphyria.Hemin is an Heme oxygenase (HO)-1 inducer.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!",651.94,"16009-13-5",{"v":20,"d":"20.00"},30.68,"<1","N/A","https://www.selleckchem.com/products/hemin.html","C34H32ClFeN4O4","Free Base","protohemin","CC1=C(CCC(O)=O)C\\2=N\\C1=C/C3=C(C=C)C(=C4\\C=C5/N=C(/C=C6\\N([Fe](Cl)[N]34)\\C(=C2)C(=C6C)CCC(O)=O)C(=C5C=C)C)C",6.404,4,0,8]
["S6920","SEA0400","h10","L6400-08","in 10mM DMSO","Calcium Channel,ERK,NCX,p38 MAPK,ROS,Sodium Channel","Transmembrane Transporters","SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.",371.38,"223104-29-8",{"v":74,"d":"74.00"},199.26,"<1","N/A","https://www.selleckchem.com/products/sea0400.html","C21H19F2NO3","Free Base","N/A","CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(=C3)F)C=C2)C(=C1)N",4.954,3,1,7]
["S6962","TPEN","a11","L6400-08","in 10mM DMSO","Apoptosis related,NOS","Apoptosis","TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling. TPEN (TPEDA) may be a potential therapeutic strategy for APL (acute promyelocytic leukemia).",424.54,"16858-02-9",{"v":85,"d":"85.00"},200.22,"<1","N/A","https://www.selleckchem.com/products/tpen.html","C26H28N6","Free Base","TPEDA","C(CN(CC1=NC=CC=C1)CC2=NC=CC=C2)N(CC3=NC=CC=C3)CC4=NC=CC=C4",{"v":3.05,"d":"3.050"},4,0,11]
["S9161","Ziyuglycoside II","b11","L6400-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.",604.81,"35286-59-0",{"v":100,"d":"100.00"},165.34,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/ziyuglycoside-ii.html","C35H56O8","Free Base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1(C)O)C(O)=O",4.107,3,3,3]
["S9187","Phillygenin","c11","L6400-08","in 10mM DMSO","LDL","Metabolism","Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.",372.41,"487-39-8",{"v":74,"d":"74.00"},198.71,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/phillygenin.html","C21H24O6","Free Base","Sylvatesmin","COC1=C(OC)C=C(C=C1)C2OCC3C2COC3C4=CC(=C(O)C=C4)OC",2.409,5,1,5]
["S3168","cis-Resveratrol","d11","L6400-08","in 10mM DMSO","Apoptosis related,COX,DNA/RNA Synthesis,IκB/IKK,Lipoxygenase,Nrf2,Sirtuin","Immunology & Inflammation","cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.",228.24,"61434-67-1",{"v":46,"d":"46.00"},201.54,"<1","N/A","http://www.selleckchem.com/products/cis-resveratrol.html","C14H12O3","Free Base","cis-RESV, cRes, (Z)-Resveratrol","OC1=CC=C(C=C1)\\C=C/C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S3387","ML351","e11","L6400-08","in 10mM DMSO","Lipoxygenase","Metabolism","ML351 is a selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) with IC50 of 200 nM.",249.27,"847163-28-4",{"v":50,"d":"50.00"},200.59,"<1","N/A","http://www.selleckchem.com/products/ml351.html","C15H11N3O","Free Base","N/A","CNC1=C(N=C(O1)C2=CC=CC3=CC=CC=C23)C#N",2.801,2,1,2]
["S3565","Brequinar Sodium","f11","L6400-08","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.",397.35,"96201-88-6",{"v":79,"d":"79.00"},198.82,{"v":26,"d":"26.00"},65.43,"http://www.selleckchem.com/products/bipenquinate.html","C23H14F2NNaO2","Sodium","Bipenquinate, BRQ, DUP-785, NSC 368390","CC1=C(C(=O)O[Na])C2=CC(=CC=C2N=C1C3=CC=C(C=C3)C4=C(F)C=CC=C4)F",6.099,3,0,4]
["S3590","Triolein","g11","L6400-08","in 10mM DMSO","Interleukins,MMP,ROS","Proteases","Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.",885.43,"122-32-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/triolein.html","C57H104O6","Free Base","N/A","CCCCCCCC\\C=C/CCCCCCCC(=O)OCC(COC(=O)CCCCCCC\\C=C/CCCCCCCC)OC(=O)CCCCCCC\\C=C/CCCCCCCC",20.925,6,0,53]
["S4419","Ensulizole","h11","L6400-08","in 10mM DMSO","ROS","Immunology & Inflammation","Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.",{"v":274.3,"d":"274.30"},"27503-81-7",{"v":5,"d":"5.00"},18.23,"<1","N/A","http://www.selleckchem.com/products/ensulizole.html","C13H10N2O3S","Free Base","PBSA","O[S](=O)(=O)C1=CC2=C(C=C1)N=C([NH]2)C3=CC=CC=C3",2.603,1,1,2]
["S4425","Rifamycin S","a2","L6400-09","in 10mM DMSO","Antibiotics,Bacterial,ROS","Immunology & Inflammation","Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.",695.75,"13553-79-2",{"v":100,"d":"100.00"},143.73,"<1","N/A","http://www.selleckchem.com/products/rifamycin-s.html","C37H45NO12","Free Base","N/A","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=O)C(=CC4=O)NC(=O)\\C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C",2.779,9,4,3]
["S4452","ML162","b2","L6400-09","in 10mM DMSO","Ferroptosis,Peroxidases","Apoptosis","ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.",{"v":477.4,"d":"477.40"},"1035072-16-2",{"v":95,"d":"95.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/ml162.html","C23H22Cl2N2O3S","Free Base","N/A","COC1=C(Cl)C=C(C=C1)N(C(C(=O)NCCC2=CC=CC=C2)C3=CC=CS3)C(=O)CCl",4.973,3,1,9]
["S5190","Crizotinib hydrochloride","c2","L6400-09","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",{"v":486.8,"d":"486.80"},"1415560-69-8",{"v":97,"d":"97.00"},199.26,{"v":97,"d":"97.00"},199.26,"http://www.selleckchem.com/products/crizotinib-hydrochloride.html","C21H23Cl3FN5O","Hydrochloride","Xalkori, PF-02341066 hydrochloride","Cl.CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",4.075,3,2,5]
["S5199","Oxytetracycline hydrochloride","d2","L6400-09","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.",496.89,"2058-46-0",{"v":99,"d":"99.00"},199.24,{"v":99,"d":"99.00"},199.24,"http://www.selleckchem.com/products/oxytetracycline-hydrochloride.html","C22H25ClN2O9","Hydrochloride","OTC, Oxycycin, Stevacin, Terramycin","Cl.CN(C)C1C2C(O)C3C(=C(O)C4=C(C=CC=C4O)C3(C)O)C(=O)C2(O)C(=C(C(N)=O)C1=O)O",-1.629,3,5,2]
["S5864","Levocetirizine","e2","L6400-09","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor.",388.89,"130018-77-8",{"v":78,"d":"78.00"},200.57,{"v":78,"d":"78.00"},200.57,"http://www.selleckchem.com/products/levocetirizine.html","C21H25ClN2O3","Free Base","LCZ, (R)-Cetirizine","OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",0.453,2,0,8]
["S5898","Efonidipine hydrochloride monoethanolate","f2","L6400-09","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) hydrochloride monoethanolate is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. Efonidipine hydrochloride monoethanolate also suppresses aldosterone secretion from the adrenal.",714.18,"111011-76-8",{"v":100,"d":"100.00"},140.02,"<1","N/A","http://www.selleckchem.com/products/efonidipine-hydrochloride-monoethanolate.html","C36H45ClN3O8P","Hydrochloride monoethanolate","NZ-105 hydrochloride monoethanolate","Cl.CCO.CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",5.329,4,2,11]
["S5937","DL-Carnitine","g2","L6400-09","in 10mM DMSO","Others","Others","DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias.",{"v":161.2,"d":"161.20"},"461-06-3, 406-76-8",{"v":32,"d":"32.00"},198.51,{"v":32,"d":"32.00"},198.51,"http://www.selleckchem.com/products/dl-carnitine.html","C7H15NO3","Free Base","(±)-Carnitin","C[N+](C)(C)CC(O)CC([O-])=O",{"v":-3.29,"d":"-3.290"},0,1,4]
["S5966","Amlodipine maleate","h2","L6400-09","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",524.95,"88150-47-4",{"v":100,"d":"100.00"},190.49,"<1","N/A","http://www.selleckchem.com/products/amlodipine-maleate.html","C24H29ClN2O9","Maleate","Amvaz, UK-48340 maleate","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C.OC(=O)\\C=C/C(O)=O",-0.864,7,2,12]
["S9721","Farudodstat","a3","L6400-09","in 10mM DMSO","AP-1,Apoptosis related,Dehydrogenase","Metabolism","Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.",356.32,"1035688-66-4",{"v":71,"d":"71.00"},199.26,"<1","N/A","http://www.selleckchem.com/products/aslan003.html","C19H14F2N2O3","Free Base","LAS 186323,ASLAN003","COC1=CC=CC(=C1)C2=CC(=C(NC3=NC=CC=C3C(O)=O)C(=C2)F)F",4.311,3,1,5]
["S9723","CDDO-Im","b3","L6400-09","in 10mM DMSO","Nrf2,PPAR","Immunology & Inflammation","CDDO-Im (CDDO-Imidazolide, RTA-403, TP-235) is an activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR). CDDO-Im binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. CDDO-Im inhibits inflammatory response and tumor growth in vivo.",541.72,"443104-02-7",{"v":56,"d":"56.00"},103.37,"<1","N/A","http://www.selleckchem.com/products/cddo-im.html","C34H43N3O3","Free Base","CDDO-Imidazolide, RTA-403, TP-235","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C5(C)C=C(C#N)C(=O)C(C)(C)C5CCC34C)C(=O)[N]6C=CN=C6",5.484,4,0,1]
["S6000","CID44216842","c3","L6400-09","in 10mM DMSO","Rho","Cell Cycle","CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.",486.38,"1222513-26-9",{"v":97,"d":"97.00"},199.43,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/cid44216842.html","C22H20BrN3O3S","Free Base","Cdc42-IN-1","COC1=CC(=CC=C1)C2=NN(C(C2)C3=CC=C(Br)C=C3)C4=CC=C(C=C4)[S](N)(=O)=O",4.618,4,1,5]
["S6875","CASIN","d3","L6400-09","in 10mM DMSO","Rho","Cell Cycle","CASIN (Pirl1-related Compound 2) directly inhibits activation of Cdc42/RhoGDI with IC50 of 2 μM.",{"v":306.4,"d":"306.40"},"425399-05-9",{"v":61,"d":"61.00"},199.09,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/casin.html","C20H22N2O","Free Base","Pirl1-related Compound 2","OCCNC1CCCC2=C1[NH]C3=C2C=C(C=C3)C4=CC=CC=C4",{"v":3.84,"d":"3.840"},0,3,4]
["S6909","Levomefolic acid","e3","L6400-09","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.",459.46,"31690-09-2",{"v":46,"d":"46.00"},100.12,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/levomefolic-acid.html","C20H25N7O6","Free Base","5-MTHF, LMSR, Metafolin, Nutrifolin","CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(O)=O)C(O)=O)CNC3=C1C(=O)N=C(N)N3",-0.794,5,5,9]
["S9733","Mito-TEMPO","f3","L6400-09","in 10mM DMSO","RIP kinase","Apoptosis","Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.",510.03,"1334850-99-5",{"v":100,"d":"100.00"},196.07,{"v":100,"d":"100.00"},196.07,"http://www.selleckchem.com/products/mito-tempo.html","C29H35N2O2P.Cl","Free Base","N/A","[Cl-].CC1(C)CC(CC(C)(C)N1[O])NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4",2.297,1,1,6]
["S9776","AG-636","g3","L6400-09","in 10mM DMSO","Dehydrogenase","Metabolism","AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.",343.38,"1623416-31-8",{"v":35,"d":"35.00"},101.93,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ag-636.html","C21H17N3O2","Free Base","N/A","C[N]1N=NC2=CC(=CC(=C12)C(O)=O)C3=CC=C(C=C3)C4=CC=CC=C4C",4.793,3,0,3]
["S9839","SRS11-92","h3","L6400-09","in 10mM DMSO","Ferroptosis","Apoptosis","SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.",352.47,"1467047-25-1",{"v":70,"d":"70.00"},{"v":198.6,"d":"198.60"},"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/srs11-92.html","C22H28N2O2","Free Base","AA9","CCOC(=O)C1=CC=C(NC2CCCCC2)C(=C1)NCC3=CC=CC=C3",5.093,2,2,8]
["S9840","SRS16-86","a4","L6400-09","in 10mM DMSO","Ferroptosis","Apoptosis","SRS16-86, a novel third-generation ferrostatin, is an inhibitor of ferroptosis.",432.56,"1793052-96-6",{"v":5,"d":"5.00"},11.56,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/srs16-86.html","C26H32N4O2","Free Base","N/A","CC(C)(C)OC(=O)C1=CC(=C(NC23CC4CC(CC(C4)C2)C3)C=C1)N=CC5=CN=CN=C5",4.386,5,1,7]
["E0035","CP-31398 Dihydrochloride","b4","L6400-09","in 10mM DMSO","p53","Apoptosis","CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.",435.39,"1217195-61-3",{"v":87,"d":"87.00"},199.82,{"v":87,"d":"87.00"},199.82,"http://www.selleckchem.com/products/cp-31398-dihydrochloride.html","C22H28Cl2N4O","Dihydrochloride","N/A","Cl.Cl.COC1=CC=C(C=C1)/C=C/C2=NC3=CC=CC=C3C(=N2)NCCCN(C)C",4.772,3,1,8]
["E0441","NK-252","c4","L6400-09","in 10mM DMSO","Nrf2","Immunology & Inflammation","NK-252 is an activator of Nrf2  and interacts with the Nrf2-binding site of Keap1.",285.26,"1414963-82-8",{"v":57,"d":"57.00"},199.82,"<1","N/A","https://www.selleckchem.com/products/nk-252.html","C13H11N5O3","free base","N/A","O=C(NCC1=NC=CC=C1)NC2=NN=C(O2)C3=CC=CO3",{"v":0.83,"d":"0.830"},6,2,4]
["E1141","KI696","d4","L6400-09","in 10mM DMSO","NRF2","Immunology & Inflammation","KI696 is a potent and selective inhibitor of KEAP1/NRF2 interaction. KI696 induces the expression of each of the Nqo1, Ho-1, Txnrd1, Srxn1, Gsta3, Gclc genes in a dose-dependent manner.",550.63,"1799974-70-1",{"v":100,"d":"100.00"},181.61,"<1","N/A","https://www.selleckchem.com/products/ki696.html","C28H30N4O6S","free base","N/A","COC1=C2[N](C)N=NC2=CC(=C1)C(CC(O)=O)C3=CC(=C(C)C=C3)CN4CC(C)OC5=CC=CC=C5[S]4(=O)=O",4.395,7,0,7]
["E1220","CBR-470-1","e4","L6400-09","in 10mM DMSO","phosphoglycerate kinase","Metabolism","CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.",{"v":365.9,"d":"365.90"},"2416095-06-0",{"v":73,"d":"73.00"},199.51,"<1","N/A","https://www.selleckchem.com/products/cbr-470-1.html","C14H20ClNO4S2","chlorosulfate","N/A","CC(C)CNC1C[S](=O)(=O)CC1[S](=O)(=O)C2=CC=C(Cl)C=C2",2.289,4,1,5]
["E1256","Ibotenic acid","f4","L6400-09","in 10mM DMSO","Others","Others","Ibotenic acid((RS)-Ibotenic acid; DL-Ibotenic acid) is a neuroexcitatory amino acid originally isolated from Amanita species. It exhibits agonist activity at both N-methyl-D-aspartate (NMDA) and trans-ACPD) or metabolotropic quisqualate (Qm) receptor sites.",158.11,"2552-55-8",{"v":32,"d":"32.00"},202.39,{"v":4,"d":"4.00"},{"v":25.3,"d":"25.30"},"https://www.selleckchem.com/products/ibotenicacid.html","C5H6N2O4","free base","(RS)-Ibotenic acid; DL-Ibotenic acid","NC(C(O)=O)C1=CC(=O)NO1",-4.472,3,2,2]
["E1375","JKE-1674","g4","L6400-09","in 10mM DMSO","Peroxidases","Metabolism","JKE-1674 is an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. It is an orally active inhibitor of glutathione peroxidase 4 (GPX4) and also is an active metabolite of GPX4 inhibitor ML-210. JKE-1674 can convert into a nitrile oxide JKE-1777.",{"v":451.3,"d":"451.30"},"2421119-60-8",{"v":90,"d":"90.00"},199.42,"<1","N/A","https://www.selleckchem.com/products/jke-1674.html","C20H20Cl2N4O4","free base","N/A","ON=C(C[N](=O)=O)C(=O)N1CCN(CC1)C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3",3.982,2,0,6]
["E2371","YLF-466D","h4","L6400-09","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","YLF-466D is an AMPK activator that inhibits platelet aggregation with IC50 of 84 μM.",465.93,"1273323-67-3",{"v":93,"d":"93.00"},{"v":199.6,"d":"199.60"},"<1","N/A","https://www.selleckchem.com/products/ylf-466d.html","C29H20CINO3","free base","N/A","OC(=O)C1=CC=CC(=C1)CN2C(=O)C(/C3=CC=CC=C23)=C(C4=CC=CC=C4)/C5=CC=C(Cl)C=C5",6.293,2,0,5]
["E2902","Sodium Pyruvate","a5","L6400-09","in 10mM DMSO","Others","Others","Sodium Pyruvate(Sodium 2-oxopropanoate) is a compound produced in the glycolytic pathway. Sodium Pyruvate is a free radical scavenger that can scavenge ROS.",111.05,"113-24-6",{"v":4,"d":"4.00"},36.02,{"v":22,"d":"22.00"},198.11,"https://www.selleckchem.com/products/sodium-pyruvate.html","C3H4O3.Na","sodium","Sodium 2-oxopropanoate","[Na;v0].CC(=O)C(O)=O",-0.329,2,0,1]
["E2943","Pifithrin-β","b5","L6400-09","in 10mM DMSO","p53","Apoptosis","Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.",268.38,"60477-34-1",{"v":27,"d":"27.00"},{"v":100.6,"d":"100.60"},"<1","N/A","https://www.selleckchem.com/products/pifithrin-beta.html","C16H16N2S","free base","PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide","CC1=CC=C(C=C1)C2=C[N]3C4=C(CCCC4)SC3=N2",4.125,1,0,1]
["E1574","FSEN1","c5","L6400-09","in 10mM DMSO","Ferroptosis","Apoptosis","FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. It triggers iron death in cancer cells by inhibiting FSP1 and can be used in research of cancer.",484.41,"862808-01-3",{"v":8,"d":"8.00"},16.51,"<1","N/A","https://www.selleckchem.com/products/fsen1.html","C22H22BrN5OS","free base","N/A","COC1=CC=C(C=C1)N2CCN(CC2)CC3=C[N]4C(=NN=C4C5=CC=C(Br)C=C5)S3",4.489,3,0,5]
["E1735","PK11007","d5","L6400-09","in 10mM DMSO","p53","Apoptosis","PK11007 is a thiol-reactive anticancer agent that stabilizes  p53  via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant  p53  cancer cell death by increasing reactive oxygen species (ROS) levels.",427.86,"874146-69-7",{"v":86,"d":"86.00"},{"v":201,"d":"201.00"},"<1","N/A","https://www.selleckchem.com/products/pk11007.html","C15H11ClFN5O3S2","free base","N/A","CC1=NN=C(NC(=O)C2=NC(=NC=C2Cl)[S](=O)(=O)CC3=CC=C(F)C=C3)S1",2.499,7,1,5]
["E1773","Fasoracetam (NS 105)","e5","L6400-09","in 10mM DMSO","GluR","Neuronal Signaling","Fasoracetam (NS 105) is a metabotropic glutamate receptor activator with a potential to treat vascular dementia.",196.25,"110958-19-5",{"v":39,"d":"39.00"},198.73,{"v":39,"d":"39.00"},198.73,"https://www.selleckchem.com/products/fasoracetam-ns-105.html","C10H16N2O2","free base","NS 105","O=C1CCC(N1)C(=O)N2CCCCC2",-0.053,2,1,1]
["E1812","N6F11","f5","L6400-09","in 10mM DMSO","Ferroptosis","Apoptosis","N6F11 is an inducer of ferroptosis. N6F11 is bound to the RING domain of the E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of glutathione peroxidase 4 (GPX4), resulting in proteasomal degradation.",311.19,"851398-76-0",{"v":20,"d":"20.00"},64.27,"<1","N/A","https://www.selleckchem.com/products/n6f11.html","C13H8Cl2N2OS","free base","N/A","ClCC1=NC(=O)C2=C(N1)C=C(S2)C3=CC=C(Cl)C=C3",3.789,2,1,2]
["E1203","Sirpiglenastat","g5","L6400-09","in 10mM DMSO","Glutaminase","Proteases","Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities.",441.48,"2079939-05-0",{"v":88,"d":"88.00"},199.33,"<1","N/A","https://www.selleckchem.com/products/sirpiglenastat.html","C22H27N5O5","free base","DRP-104","CC(C)OC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(C)=O",1.729,5,3,12]
["E1535","icFSP1","h5","L6400-09","in 10mM DMSO","Ferroptosis","Metabolism","icFSP1 is a potent, selective human ferroptosis suppressor protein-1 (hFSP1) inhibitor, promotes ferroptosis and indirectly inhibits FSP1 by inducing condensate formation.",459.49,"N/A",{"v":100,"d":"100.00"},217.63,"<1","N/A","https://www.selleckchem.com/products/icfsp1.html","N/A","free base","N/A","COC1=CC(=CC(=C1OC)OC)CC(=O)NC2=CC=C(C=C2)N3C(=NC4=C(C=CC=C4)C3=O)C",3.382,6,1,7]
["E1537","MMRi62","a6","L6400-09","in 10mM DMSO","MDM2/MDMX","Apoptosis","MMRi62 is a ferroptosis inducer, targeting MDM2-MDM4 with Kd value of 1.39 μM. It exhibits a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy.",396.27,"352693-80-2",{"v":79,"d":"79.00"},199.36,"<1","N/A","https://www.selleckchem.com/products/mmri62.html","C21H15Cl2N3O","free base","N/A","OC1=C(C=CC2=C1N=CC=C2)C(NC3=CC=CC=N3)C4=C(Cl)C(=CC=C4)Cl",5.496,2,2,4]
["S4684","Sildenafil","b6","L6400-09","in 10mM DMSO","PDE","Metabolism","Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.",474.58,"139755-83-2","N/A",">10","N/A","N/A","http://selleckchem.com/products/sildenafil.html","C22H30N6O4S","free base","Revatio, UK-92480, Viagra","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4",2.247,6,1,7]
["S1749","L-Glutamine","a2","L6400-10","in 10mM Water","Others","Others","L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.",146.14,"56-85-9","<1","N/A",{"v":29,"d":"29.00"},198.44,"http://selleckchem.com/products/Glutamine.html","C5H10N2O3","free base","N/A","NC(CCC(N)=O)C(O)=O",-4.087,2,2,4]
["S1893","D-glutamine","b2","L6400-10","in 10mM Water","GluR","Neuronal Signaling","D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.",146.14,"5959-95-5","<1","N/A",{"v":9,"d":"9.00"},61.58,"http://selleckchem.com/products/D-glutamine.html","C5H10N2O3","free base","N/A","NC(CCC(N)=O)C(O)=O",-4.087,2,2,4]
["S1985","ATP disodium","c2","L6400-10","in 10mM Water","Others","Others","ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.",551.14,"987-65-5","<1","N/A",{"v":100,"d":"100.00"},181.44,"http://selleckchem.com/products/atp-Adenosine-Triphosphate.html","C10H14N5O13P3.2Na","Disodium Salt","Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate","[Na+].[Na+].NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(=O)O[P]([O-])(=O)O[P](O)([O-])=O)C(O)C3O",-5.474,7,3,8]
["S1999","Sodium butyrate","d2","L6400-10","in 10mM Water","Apoptosis related,Autophagy,HDAC","Epigenetics","Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.",110.09,"156-54-7","<1","N/A",{"v":22,"d":"22.00"},199.84,"http://selleckchem.com/products/Sodium-butyrate.html","C4H7NaO2","Sodium Salt","NaB, Butanoic acid sodium salt","[Na+].CCCC([O-])=O",-0.556,0,0,2]
["S2129","Fudosteine","e2","L6400-10","in 10mM Water","Others","Metabolism","Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.",179.24,"13189-98-5","<1","N/A",{"v":36,"d":"36.00"},200.85,"http://selleckchem.com/products/Fudosteine.html","C6H13NO3S","free base","N/A","NC(CSCCCO)C(O)=O",-3.373,1,2,6]
["S2462","Donepezil HCl","f2","L6400-10","in 10mM Water","AChR","Neuronal Signaling","Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.",{"v":416,"d":"416.00"},"120011-70-3","<1","N/A",{"v":5,"d":"5.00"},12.02,"http://selleckchem.com/products/Donepezil-hydrochloride(Aricept).html","C24H29NO3.HCl","Hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)CC2=C1",4.951,3,0,6]
["S3631","(S)-Methylisothiourea sulfate","g2","L6400-10","in 10mM Water","ROS","Immunology & Inflammation","(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).",139.19,"867-44-7","<1","N/A",{"v":27,"d":"27.00"},193.98,"http://selleckchem.com/products/s-methylisothiourea-sulfate.html","C2H6N2S.1/2H2SO4","sulfate","N/A","CSC(N)=N",1.158,0,1,1]
["S3793","Phytic acid","h2","L6400-10","in 10mM Water","Xanthine Oxidase","Metabolism","Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.",660.04,"83-86-3","<1","N/A",{"v":100,"d":"100.00"},151.51,"http://selleckchem.com/products/phytic-acid.html","C6H18O24P6","free base","Inositol polyphosphate, Inositol hexakisphosphate","O[P](O)(=O)OC1C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C1O[P](O)(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3852","L-Theanine","a3","L6400-10","in 10mM Water","Others","Others","L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation.",{"v":174.2,"d":"174.20"},"3081-61-6","<1","N/A",{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-theanine.html","C7H14N2O3","free base","N/A","CCNC(=O)CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3963","DL-Glutamine","b3","L6400-10","in 10mM Water","Others","Others","DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.",146.14,"6899-04-3","<1","N/A",{"v":29,"d":"29.00"},198.44,"http://selleckchem.com/products/dl-glutamine.html","C5H10N2O3","free base","Glutamin, 2-amino-4-carbamoylbutanoic acid","NC(CCC(N)=O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3973","L-SelenoMethionine","c3","L6400-10","in 10mM Water","ROS","Immunology & Inflammation","L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.",196.11,"3211-76-5","<1","N/A",{"v":39,"d":"39.00"},198.87,"http://selleckchem.com/products/l-selenomethionine.html","C5H11NO2Se","free base","N/A","C[Se]CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4117","Histamine Phosphate","d3","L6400-10","in 10mM Water","Histamine Receptor","Neuronal Signaling","Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.",307.14,"51-74-1","<1","N/A",{"v":42,"d":"42.00"},136.75,"http://selleckchem.com/products/histamine-phosphate.html","C5H9N.2H3O4P","Phosphate","Histamine diphosphate","NCCC1=C[NH]C=N1.O[P](O)(O)=O.O[P](O)(O)=O",-1.651,1,2,2]
["S4245","Sodium ascorbate","e3","L6400-10","in 10mM Water","Vitamin","Metabolism","Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.",198.11,"134-03-2",{"v":2,"d":"2.00"},9.94,{"v":40,"d":"40.00"},198.88,"http://selleckchem.com/products/sodium-ascorbate.html","C6H7NaO6","Sodium Salt","Sodium Vitamin C","[NaH].OCC(O)C1OC(=O)C(O)C1O",-2.229,2,4,2]
["S4298","Amifostine trihydrate","f3","L6400-10","in 10mM Water","Others","Others","Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.",268.27,"112901-68-5","<1","N/A",{"v":42,"d":"42.00"},156.56,"http://selleckchem.com/products/amifostine.html","C5H15N2O3PS.3H2O","trihydrate","WR2721 trihydrate","O.O.O.NCCCNCCS[P](O)(O)=O",-1.471,0,2,7]
["S4360","Tolmetin Sodium","g3","L6400-10","in 10mM Water","COX","Immunology & Inflammation","Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.",{"v":315.3,"d":"315.30"},"64490-92-2","<1",{"v":0,"d":"0.00"},{"v":63,"d":"63.00"},199.81,"http://www.selleckchem.com/products/tolmetin-sodium.html","C15H14NO3.Na.2H2O","sodium","MCN2559","O.O.C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(=O)O[Na]",2.943,3,0,5]
["S4606","Glutathione","h3","L6400-10","in 10mM Water","Glutathione","Metabolism","Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.",307.32,"70-18-8","<1","N/A",{"v":61,"d":"61.00"},198.49,"http://selleckchem.com/products/glutathione.html","C10H17N3O6S","free base","Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine","NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O",-4.772,4,3,9]
["S4721","L-Glutamic acid monosodium salt","a4","L6400-10","in 10mM Water","GluR","Neuronal Signaling","L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods.   L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.",169.11,"142-47-2","<1","N/A",{"v":33,"d":"33.00"},195.14,"http://selleckchem.com/products/l-glutamic-acid-monosodium-salt.html","C5H8NO4.Na","sodium salt","Monosodium glutamate, MSG","NC(CCC(=O)O[Na])C(O)=O",-3.368,3,1,5]
["S4740","Sodium ferulate","b4","L6400-10","in 10mM Water","5-HT Receptor","Neuronal Signaling","Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.",216.17,"24276-84-4",{"v":2,"d":"2.00"},9.25,{"v":43,"d":"43.00"},198.92,"http://selleckchem.com/products/ferulic-acid-sodium.html","C10H9O4.Na","Sodium salt","Ferulic acid sodium salt","[Na+].COC1=CC(=CC=C1O)\\C=C\\C([O-])=O",0.195,1,1,3]
["S4741","Danshensu","c4","L6400-10","in 10mM Water","P450 (e.g. CYP17)","Metabolism","Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. Danshensu inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively.",198.17,"76822-21-4","<1","N/A",{"v":23,"d":"23.00"},116.06,"http://selleckchem.com/products/danshensu.html","C9H10O5","free base","Salvianic acid A","OC(CC1=CC=C(O)C(=C1)O)C(O)=O",0.679,1,3,3]
["S4786","S-Methyl-L-cysteine","d4","L6400-10","in 10mM Water","Others","Others","S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis.",135.18,"1187-84-4","<1","N/A",{"v":27,"d":"27.00"},199.73,"http://selleckchem.com/products/s-methyl-l-cysteine.html","C4H9NO2S","free base","S-Methylcysteine","CSCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4791","S-allyl-L-cysteine","e4","L6400-10","in 10mM Water","Others","Apoptosis","S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.",161.22,"21593-77-1","<1","N/A",{"v":32,"d":"32.00"},198.49,"http://selleckchem.com/products/s-allyl-l-cysteine.html","C6H11NO2S","free base","S-Allylcysteine","NC(CSCC=C)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4993","Timonacic","f4","L6400-10","in 10mM Water","Others","Others","Timonacic (Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid) is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities.",133.17,"444-27-9",{"v":1,"d":"1.00"},7.51,{"v":27,"d":"27.00"},202.75,"http://www.selleckchem.com/products/timonacic.html","C4H7NO2S","Free Base","Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid","OC(=O)C1CSCN1",-2.889,1,1,1]
["S5115","Sodium L-ascorbyl-2-phosphate","g4","L6400-10","in 10mM Water","c-Met","Protein Tyrosine Kinase","Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects.  Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective  antioxidant and a stimulator of hepatocyte growth factor (HGF) production.",322.05,"66170-10-3","<1","N/A",{"v":64,"d":"64.00"},198.73,"http://selleckchem.com/products/sodium-l-ascorbyl-2-phosphate.html","C6H6O9P.3Na","sodium salt","Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate","[Na+].[Na+].[Na+].OCC(O)C1OC(=O)C(=C1[O-])O[P]([O-])([O-])=O",{"v":-5.03,"d":"-5.030"},3,2,4]
["S5226","L-carnosine","h4","L6400-10","in 10mM Water","Others","Others","L-carnosine (Karnozin) is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress.",226.23,"305-84-0","<1","N/A",{"v":45,"d":"45.00"},198.91,"http://selleckchem.com/products/l-carnosine.html","C9H14N4O3","free base","Karnozin","NCCC(=O)NC(CC1=C[NH]C=N1)C(O)=O",-4.268,3,3,6]
["S5545","DL-Serine","a5","L6400-10","in 10mM Water","PKM","Metabolism","Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.",105.09,"302-84-1","<1","N/A",{"v":8,"d":"8.00"},76.13,"http://selleckchem.com/products/dl-serine.html","C3H7NO3","salt","N/A","NC(CO)C(O)=O",-4.049,1,2,2]
["S5584","Citronellol","b5","L6400-10","in 10mM Water","Apoptosis related,Caspase,RIP kinase,ROS,TNF-alpha","Apoptosis","Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.",156.27,"106-22-9","<1","N/A",{"v":31,"d":"31.00"},198.37,"http://selleckchem.com/products/citronellol.html","C10H20O","free base","Dihydrogeraniol, (±)-β-Citronellol","CC(CCO)CCC=C(C)C",3.049,0,1,5]
["S5635","L-cysteine","c5","L6400-10","in 10mM Water","Others","Others","Cysteine is a naturally occurring, sulfur-containing amino acid which is important for protein synthesis, detoxification, and also exerts diverse metabolic functions.",121.16,"52-90-4","<1","N/A",{"v":24,"d":"24.00"},198.09,"http://selleckchem.com/products/l-cysteine.html","C3H7NO2S","free base","N/A","NC(CS)C(O)=O",-3.078,1,1,2]
["S5706","Edetate Trisodium","d5","L6400-10","in 10mM Water","Others","Others","Edetate Trisodium (EDTA trisodium salt, ethylenediaminetetraacetic acid) is the organic sodium salt of ethylenediaminetetraacetic acid (EDTA). EDTA is a chelating agent capable of removing a heavy metal, such as lead or mercury, from the blood.",358.19,"150-38-9","<1","N/A",{"v":36,"d":"36.00"},100.51,"https://www.selleckchem.com/products/edetate-trisodium.html","C10H13N2Na3O8","free base","EDTA Trisodium, ethylenediaminetetraacetic acid Trisodium","[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O",-9.072,1,0,11]
["S5721","Edetate calcium disodium","e5","L6400-10","in 10mM Water","Others","Others","Edetate (EDTA) calcium disodium is a chelating agent that is primarily used for the management of severe lead poisoning.",374.27,"62-33-9","<1","N/A",{"v":75,"d":"75.00"},200.39,"http://www.selleckchem.com/products/edetate-calcium-disodium.html","C10H12CaN2Na2O8","disodium salt","EDTA calcium disodium","[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O",-7.512,0,0,11]
["S6266","(S)-Glutamic acid","f5","L6400-10","in 10mM Water","GluR","Neuronal Signaling","(S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist.",147.13,"56-86-0","N/A","N/A",{"v":4,"d":"4.00"},27.19,"http://www.selleck.cn/products/s-glutamic-acid.html","C5H9NO4","free base","L-Glutamic acid","NC(CCC(O)=O)C(O)=O",-3.459,2,1,4]
["S6445","Chlorophyllin (sodium copper salt)","g5","L6400-10","in 10mM Water","Others","Others","Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent.",724.15,"11006-34-1","<1","N/A",{"v":13,"d":"13.00"},17.95,"http://www.selleck.cn/products/chlorophyllin.html","C34H31CuN4Na3O6","sodium copper salt","N/A","[Na+].[Na+].[Na+].[Cu++]|1|2|3|[N-]4C5=C(C)C(=C4C=C6N|1=C(C=C7[N-]|2C(=C(CC([O-])=O)C8=N|3C(=C5)C(C)C8CCC([O-])=O)C(=C7C)C([O-])=O)C(=C6C)CC)C=C",-1.452,0,0,8]
["S7873","Disodium (R)-2-Hydroxyglutarate","h5","L6400-10","in 10mM Water","ROS","Immunology & Inflammation","Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.",192.08,"103404-90-6","<1","N/A",{"v":38,"d":"38.00"},197.83,"http://selleckchem.com/products/disodium-r-2-hydroxyglutarate.html","C5H6Na2O5","disodium salt","D-α-Hydroxyglutaric acid disodium","OC(CCC(=O)O[Na])C(=O)O[Na]",-0.509,4,1,6]
["S9344","DL-Methionine","a6","L6400-10","in 10mM Water","Antiviral","Microbiology","DL-Methionine is an amino acid that has a role in the defence of oxidative stress.",149.21,"59-51-8","N/A",{"v":0,"d":"0.00"},{"v":6,"d":"6.00"},40.21,"https://www.selleckchem.com/products/dl-methionine.html","C5H11NO2S","free base","N/A","CSCCC(N)C(O)=O",-2.834,1,1,4]
["S4519","Citric acid trilithium salt tetrahydrate","b6","L6400-10","in 10mM Water","Others","Others","Citric acid trilithium salt tetrahydrate (Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids.",281.98,"6080-58-6","N/A","N/A",{"v":56,"d":"56.00"},{"v":198.6,"d":"198.60"},"http://selleckchem.com/products/citric-acid-trilithium-salt-tetrahydrate.html","C6H5Li3O7&bull;4H2O","free base","Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate","O.O.O.O.[Li]OC(=O)CC(O)(CC(=O)O[Li])C(=O)O[Li]",-1.875,6,0,8]
["S6871","Sodium oxamate","c6","L6400-10","in 10mM Water","Apoptosis related,CDK,LDH,ROS","Metabolism","Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH‑A. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.",111.03,"565-73-1","<1","N/A",{"v":22,"d":"22.00"},198.14,"http://www.selleckchem.com/products/sodium-oxamate.html","C2H2NNaO3","Sodium","SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt","[Na+].NC(=O)C([O-])=O",-2.531,1,1,1]
["E1689","NADPH tetrasodium salt","d6","L6400-10","in 10mM Water","Others","Others","NADPH tetrasodium salt is a ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It plays a crucial role as a cofactor in the biosynthesis of nucleotides, proteins, and fatty acids. It is essential for neutralizing elevated levels of reactive oxygen species (ROS) generated by increased metabolic activity.",837.38,"2646-71-1","<1","N/A",{"v":100,"d":"100.00"},119.42,"https://www.selleckchem.com/products/nadph-tetrasodium-salt.html","C21H30N7O17P3.4Na","Tetrasodium","N/A","[NaH].NC(=O)C1=CN(C=CC1)C2OC(CO[P](O)(=O)O[P](O)(=O)OCC3OC(C(O[P](O)(O)=O)C3O)[N]4C=NC5=C(N)N=CN=C45)C(O)C2O",-4.131,10,5,13]
["S1046","Vandetanib (ZD6474)","a2","L6400-11","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1327","Ellagic acid","b2","L6400-11","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property.",302.19,"476-66-4",{"v":3,"d":"3.00"},9.93,"<1","N/A","http://selleckchem.com/products/Ellagic-acid.html","C14H6O8","free base","Elagostasine, Gallogen","OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S1353","Ketoconazole (R 41400)","c2","L6400-11","in 2mM DMSO","Androgen Receptor,Fungal,P450 (e.g. CYP17)","Metabolism","Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.",531.43,"65277-42-1",{"v":5,"d":"5.00"},9.41,"<1","N/A","http://selleckchem.com/products/Ketoconazole.html","C26H28Cl2N4O4","free base","R 41400","CC(=O)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=CN=C4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",{"v":3.61,"d":"3.610"},5,0,7]
["S1724","Paliperidone","d2","L6400-11","in 2mM DMSO","Dopamine Receptor","Neuronal Signaling","Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.",426.48,"144598-75-4",{"v":4,"d":"4.00"},9.38,"<1","N/A","http://selleckchem.com/products/Paliperidone(Invega).html","C23H27FN4O3","free base","N/A","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCC(O)C5=N1",{"v":0,"d":"0.000"},0,0,0]
["S2251","(-)-Huperzine A (HupA)","e2","L6400-11","in 2mM DMSO","AChR,GluR","Neuronal Signaling","(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.",242.32,"102518-79-6",0.66,2.72,"<1","N/A","http://selleckchem.com/products/(-)-Huperzine-A.html","C15H18N2O","Free Base","N/A","C\\C=C/1C2CC3=C(C=CC(=O)N3)C1(N)CC(=C2)C",1.056,1,2,0]
["S3614","Lupeol","f2","L6400-11","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.",426.72,"545-47-1",{"v":1,"d":"1.00"},2.34,"<1","N/A","http://selleckchem.com/products/lupeol.html","C30H50O","free base","(3β,13ξ)-Lup-20(29)-en-3-ol, Clerodol, Monogynol B, Fagarasterol, Farganasterol","CC(=C)C1CCC2(C)CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12",7.403,0,1,1]
["S3770","Sodium Aescinate","g2","L6400-11","in 2mM DMSO","NF-κB","NF-κB","Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.  Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.",1123.21,"20977-05-3",{"v":10,"d":"10.00"},{"v":8.9,"d":"8.90"},"N/A","N/A","http://selleckchem.com/products/sodium-aescinate.html","C54H83NaO23","sodium salt","Escin sodium salt","CC(OC(C)=O)C(C)C(=O)OCC12C(O)C3OC1CC4(C)C(=CCC5C6(C)CCC(OC7OC(C(OC8OC(CO)C(O)C(O)C8O)C(O)C7OC9OCC(O)C(O)C9O)C(=O)O[Na])C(C)(CO)C6CCC45C)C2CC3(C)C",-0.485,13,10,17]
["S3891","Vincamine","h2","L6400-11","in 2mM DMSO","Others","Others","Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.",354.44,"1617-90-9",{"v":3,"d":"3.00"},8.46,"N/A","N/A","http://selleckchem.com/products/vincamine.html","C21H26N2O3","free base","Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan","CCC12CCCN3CCC4=C(C13)[N](C5=CC=CC=C45)C(O)(C2)C(=O)OC",3.546,2,0,3]
["S5116","Bilibubin","a3","L6400-11","in 2mM DMSO","Others","Others","Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.",584.66,"635-65-4",{"v":3,"d":"3.00"},5.13,"N/A","N/A","http://selleckchem.com/products/bilibubin.html","C33H36N4O6","free base","Bilirubin","CC1=C(C=C)/C(NC1=O)=C/C2=C(C)C(=C(CC3=C(CCC(O)=O)C(=C([NH]3)\\C=C\\4NC(=O)C(=C4C)C=C)C)[NH]2)CCC(O)=O",5.055,4,4,12]
["S5516","Ellagic Acid hydrate","b3","L6400-11","in 2mM DMSO","Casein Kinase","Metabolism","Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.",320.21,"314041-08-2",{"v":2,"d":"2.00"},6.25,"N/A","N/A","http://selleckchem.com/products/ellagic-acid-hydrate.html","C14H6O8.H2O","monohydrate","N/A","O.OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",1.377,4,4,0]
["S5712","Zofenopril calcium","c3","L6400-11","in 2mM DMSO","RAAS","Endocrinology & Hormones","Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.",897.17,"81938-43-4","N/A",{"v":2,"d":"2.00"},"<1","N/A","http://selleckchem.com/products/zofenopril-calcium.html","C44H44CaN2O8S4","calcium salt","SQ-26991","CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)O[Ca]OC(=O)C3CC(CN3C(=O)C(C)CSC(=O)C4=CC=CC=C4)SC5=CC=CC=C5)SC6=CC=CC=C6",8.055,8,0,20]
["S7842","LY3009120","d3","L6400-11","in 2mM DMSO","Autophagy,Raf","MAPK","LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. LY03009120 induces autophagy. Phase 1.",424.51,"1454682-72-4",{"v":3,"d":"3.00"},7.07,"<1","N/A","http://selleckchem.com/products/ly3009120.html","C23H29FN6O","Free Base","DP-4978","CNC1=NC=C2C=C(C(=NC2=N1)C)C3=CC(=C(F)C=C3C)NC(=O)NCCC(C)(C)C",4.158,4,3,6]
["S9246","Tiliroside","e3","L6400-11","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.",594.52,"20316-62-5",{"v":3,"d":"3.00"},5.05,"N/A","N/A","https://www.selleckchem.com/products/tiliroside.html","C30H26O13","free base","N/A","OC1C(O)C(COC(=O)\\C=C\\C2=CC=C(O)C=C2)OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC=C(O)C=C5)C1O",2.212,6,7,8]
["S4067","Deferiprone","a2","L6400-12","in 2mM Water","Others","Others","Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.",139.15,"30652-11-0","<1","N/A",{"v":1,"d":"1.00"},7.19,"http://selleckchem.com/products/deferiprone.html","C7H9NO2","Free Base","CP20","CN1C=CC(=O)C(=C1C)O",-0.139,1,1,0]