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[{"$nulls":3},"Anti-cancer Compound Library (Verified by Broad Institute) (96-well)-L7100"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 897 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L7100-01~11;    In 2 mM DMSO : Plate layout L7100-13"]
[{"$nulls":3},"In 10 mM Water: Plate layout L7100-12;      In 2 mM Water  : Plate layout L7100-14"]
[]
[]
[null,"Plate layout: L7100-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1002","S1020","S1048","S1065","S1085","S1100","S1115","S1133","S1157","S1172","Empty"]
[{"$nulls":3},"ABT-737","PD184352 (CI-1040)","Tozasertib","Pictilisib (GDC-0941)","Belinostat (PXD101)","MLN8054","Odanacatib (MK-0822)","Alisertib (MLN8237)","Delanzomib (CEP-18770)","Serdemetan (JNJ-26854165)"]
[null,"b","Empty","S1003","S1022","S1049","S1067","S1089","S1101","S1120","S1134","S1158","S1173","Empty"]
[{"$nulls":3},"Linifanib (ABT-869)","Ridaforolimus (Deforolimus, MK-8669)","Y-27632 2HCl","SB431542","Refametinib (RDEA119)","Vatalanib (PTK787) 2HCl","Everolimus (RAD001)","AT9283","MK-8245","WZ4002"]
[null,"c","Empty","S1005","S1029","S1052","S1069","S1090","S1103","S1121","S1141","S1159","S1175","Empty"]
[{"$nulls":3},"Axitinib (AG 013736)","Lenalidomide (CC-5013)","Elesclomol (STA-4783)","Luminespib (NVP-AUY922)","Abexinostat (PCI-24781)","ZM 447439","TW-37","Tanespimycin (17-AAG)","Ganetespib (STA-9090)","BIIB021"]
[null,"d","Empty","S1006","S1030","S1053","S1070","S1091","S1104","S1122","S1142","S1163","S1176","Empty"]
[{"$nulls":3},"Saracatinib (AZD0530)","Panobinostat (LBH589)","Entinostat (MS-275)","PHA-665752","Linsitinib (OSI-906)","GDC-0879","Mocetinostat (MGCD0103)","Alvespimycin (17-DMAG) HCl","Onalespib (AT13387)","Plinabulin (NPI-2358)"]
[null,"e","Empty","S1007","S1036","S1056","S1071","S1093","S1106","S1124","S1145","S1165","S1177","Empty"]
[{"$nulls":3},"Roxadustat (FG-4592)","Mirdametinib (PD0325901)","AC480 (BMS-599626)","HA14-1","GSK1904529A","OSU-03012 (AR-12)","BMS-754807","SNS-032 (BMS-387032)","ABT-751 (E7010)","PD98059"]
[null,"f","Empty","S1008","S1038","S1057","S1072","S1094","S1107","S1129","S1147","S1167","S1179","Empty"]
[{"$nulls":3},"Selumetinib (AZD6244)","PI-103","Obatoclax Mesylate (GX15-070)","ZSTK474","PF-04217903","Danusertib (PHA-739358)","SRT1720 HCl","Barasertib (AZD1152-HQPA)","CP-724714","WZ8040"]
[null,"g","Empty","S1013","S1044","S1060","S1078","S1095","S1109","S1130","S1152","S1170","S1186","Empty"]
[{"$nulls":3},"Bortezomib (PS-341)","Temsirolimus (CCI-779)","Olaparib (AZD2281)","MK-2206 2HCl","Dacinostat (LAQ824)","BI 2536","Sepantronium Bromide","PLX-4720","WZ3146","BIBR 1532"]
[null,"h","Empty","S1014","S1047","S1064","S1082","S1096","S1111","S1132","S1156","S1171","S1188","Empty"]
[{"$nulls":3},"Bosutinib (SKI-606)","Vorinostat (SAHA)","Masitinib (AB1010)","Vismodegib (GDC-0449)","Quisinostat (JNJ-26481585) 2HCl","Foretinib (GSK1363089)","3-Aminobenzamide","Capecitabine (RO 09-1978)","CYC116","Anastrozole (ZD-1033)"]
[]
[]
[]
[null,"Plate layout: L7100-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1191","S1216","S1229","S1251","S1278","S1330","S1369","S1454","S1485","S1515","Empty"]
[{"$nulls":3},"Fulvestrant (ICI-182780)","PFI-1 (PF-6405761)","Fludarabine Phosphate","Dienogest","Altretamine","Felbamate","Bafetinib (INNO-406)","PHA-680632","HMN-214","Pracinostat (SB939)"]
[null,"b","Empty","S1192","S1218","S1230","S1257","S1280","S1351","S1377","S1462","S1486","S1524","Empty"]
[{"$nulls":3},"Raltitrexed","Clofarabine","Flavopiridol (L86-8275)","Posaconazole (SCH 56592)","Amisulpride","Ivermectin (MK-933)","Drospirenone","AZD6482","AEE788 (NVP-AEE788)","AT7519"]
[null,"c","Empty","S1194","S1219","S1233","S1260","S1287","S1352","S1391","S1467","S1487","S1525","Empty"]
[{"$nulls":3},"CUDC-101","YM201636","2-Methoxyestradiol (2-MeOE2)","Cinacalcet (AMG-073) HCl","Bumetanide","TG100-115","Oxcarbazepine","Doxercalciferol","PHA-793887","Adavosertib (MK-1775)"]
[null,"d","Empty","S1196","S1220","S1235","S1264","S1289","S1362","S1392","S1468","S1490","S1526","Empty"]
[{"$nulls":3},"Exemestane (FCE 24304)","OSI-930","Letrozole (CGS 20267)","PD173074","Carmofur","Rigosertib (ON-01910)","Pelitinib (EKB-569)","Alfacalcidol","Ponatinib (AP24534)","Quizartinib (AC220)"]
[null,"e","Empty","S1199","S1221","S1237","S1266","S1297","S1363","S1426","S1470","S1491","S1529","Empty"]
[{"$nulls":3},"Cladribine (RWJ 26251)","Dacarbazine (NSC-45388)","Temozolomide (CCRG 81045)","WYE-354","Epothilone A","Ki8751","Repaglinide","Orantinib (SU6668)","Fludarabine (NSC 118218)","Hesperadin"]
[null,"f","Empty","S1207","S1223","S1245","S1267","S1299","S1364","S1444","S1474","S1497","S1530","Empty"]
[{"$nulls":3},"Tivozanib (AV-951)","Epirubicin (IMI 28) HCl","Latrepirdine 2HCl","Vemurafenib (PLX4032)","Floxuridine (NSC 27640)","Patupilone (Epothilone B)","Ziprasidone HCl","GSK429286A","Pralatrexate (NSC 754230)","BIX 02188"]
[null,"g","Empty","S1208","S1225","S1249","S1275","S1315","S1366","S1452","S1475","S1501","S1532","Empty"]
[{"$nulls":3},"Doxorubicin (Adriamycin) HCl","Etoposide (VP-16)","JNJ-7706621","BX-912","Ki16425","BMS-707035","Ispinesib (SB-715992)","Pimasertib (AS-703026)","Mycophenolate mofetil (RS-61443)","AZD7762"]
[null,"h","Empty","S1213","S1226","S1250","S1276","S1319","S1367","S1453","S1476","S1505","S1536","Empty"]
[{"$nulls":3},"Nelarabine","KU-0063794","Enzalutamide (MDV3100)","Adapalene","Costunolide","Amonafide","Tipifarnib (R115777)","SB525334","Aztreonam","CP-673451"]
[]
[]
[]
[null,"Plate layout: L7100-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1555","S1606","S1654","S1714","S1764","S1806","S1890","S1978","S2037","S2098","Empty"]
[{"$nulls":3},"AZD8055","Clotrimazole","Phenylbutazone","Gemcitabine (LY-188011)","Rifampin (NSC-113926)","Acipimox","Nizatidine","Methscopolamine","Candesartan Cilexetil","Bexarotene (LGD1069)"]
[null,"b","Empty","S1558","S1614","S1658","S1718","S1768","S1820","S1896","S1992","S2042","S2103","Empty"]
[{"$nulls":3},"AT7867","Riluzole (PK 26124)","Dofetilide","Adefovir Dipivoxil (GS 0840)","Cefditoren Pivoxil","Clofibrate","Hydroxyurea (NSC-32065)","Fluticasone propionate","Cyproterone Acetate","Naltrexone HCl"]
[null,"c","Empty","S1567","S1625","S1680","S1721","S1774","S1828","S1909","S2006","S2045","S2109","Empty"]
[{"$nulls":3},"Pomalidomide (CC-4047)","Ethinyl Estradiol","Disulfiram (NSC 190940)","Azathioprine","Thioguanine (NSC 752)","Proparacaine HCl","Fluvastatin (XU-62-320) Sodium","Pyrimethamine","Doxifluridine","Imidapril HCl"]
[null,"d","Empty","S1568","S1628","S1688","S1727","S1776","S1839","S1917","S2013","S2055","S2118","Empty"]
[{"$nulls":3},"PD318088","Triamcinolone Acetonide","Betamethasone Dipropionate","Levonorgestrel","Toremifene Citrate (NK 622)","Chloroxine","Crystal Violet","PF-573228","Gimeracil","Ibutilide Fumarate"]
[null,"e","Empty","S1576","S1645","S1690","S1734","S1778","S1845","S1933","S2014","S2057","S2134","Empty"]
[{"$nulls":3},"Sulfasalazine (NSC 667219)","Ketoprofen","Betamethasone Valerate","Meloxicam","Trifluridine (NSC 75520)","Cimetidine","Triamcinolone","BMS-265246","Cyclophosphamide (NSC-26271) Monohydrate","AZD8330"]
[null,"f","Empty","S1590","S1649","S1692","S1735","S1782","S1883","S1969","S2018","S2061","S2149","Empty"]
[{"$nulls":3},"TWS119","Zolmitriptan","Busulfan (NSC-750)","Mesna","Azacitidine (5-Azacytidine)","Idoxuridine","Nefiracetam","ENMD-2076 L-(+)-Tartaric acid","Lovastatin (MK-803)","GSK1292263"]
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[{"$nulls":3},"Bestatin (NK421)","Monobenzone","Desonide","Methocarbamol","Teniposide","Sparfloxacin","Nicorandil","Ginkgolide A","Lafutidine","Sonidegib (NVP-LDE225)"]
[null,"h","Empty","S1605","S1653","S1712","S1759","S1792","S1888","S1973","S2028","S2078","S2155","Empty"]
[{"$nulls":3},"Cefdinir","Tretinoin (NSC 122758)","Deferasirox (ICL-670)","Pitavastatin (NK-104) calcium","Simvastatin (MK 733)","Deflazacort","Cyclocytidine HCl","Diclazuril","Famotidine","LY2608204"]
[]
[]
[]
[null,"Plate layout: L7100-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2158","S2185","S2205","S2226","S2247","S2296","S2378","S2399","S2468","S2533","Empty"]
[{"$nulls":3},"KW-2449","Allitinib tosylate","OSI-420","Idelalisib","Buparlisib (BKM120)","Enoxolone","Butylscopolamine Bromide","Dihydromyricetin","Fenbendazole","Ritodrine HCl"]
[null,"b","Empty","S2160","S2186","S2214","S2228","S2248","S2311","S2383","S2408","S2470","S2537","Empty"]
[{"$nulls":3},"Almorexant HCl","SB505124","AZ 960","Belnacasan (VX-765)","Silmitasertib (CX-4945)","Hyodeoxycholic acid (HDCA)","Gastrodin","Cephalomannine","Fluocinolone Acetonide","Secnidazole"]
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[{"$nulls":3},"AZD1480","Sapitinib (AZD8931)","Mubritinib (TAK 165)","Telatinib","(+)-Usniacin","Oleanolic Acid","Indirubin (NSC 105327)","10-Deacetylbaccatin-III","Imatinib (STI571)","Azelastine HCl"]
[null,"d","Empty","S2170","S2193","S2217","S2235","S2265","S2335","S2387","S2412","S2487","S2561","Empty"]
[{"$nulls":3},"Givinostat (ITF2357)","GSK461364","Irinotecan (CPT-11) HCl Trihydrate","Volasertib (BI 6727)","Artesunate (WR-256283)","Oridonin (NSC-250682)","Lappaconite HBr","Genipin","Mycophenolic acid","Clomifene citrate"]
[null,"e","Empty","S2178","S2194","S2218","S2238","S2269","S2338","S2388","S2448","S2492","S2570","Empty"]
[{"$nulls":3},"AG-14361","R406","Torkinib (PP242)","Palomid 529 (P529)","Baicalin (NSC-661431)","Oxymatrine","L-carnitine","Gambogic Acid","Novobiocin Sodium (NSC 2382)","Prednisolone Acetate"]
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[{"$nulls":3},"Gandotinib (LY2784544)","Lexibulin (CYT997)","Momelotinib (CYT387)","Degrasyn (WP1130)","Chlorogenic Acid","(-)-Parthenolide","Polydatin","Colforsin","Racecadotril","Clobetasol propionate"]
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[{"$nulls":3},"Ixazomib Citrate (MLN9708) Analogue","SGI-1776 free base","SB590885","AR-42","Cyclosporin A (NSC 290193)","Tanshinone I","Salidroside","Domperidone","Ribavirin (ICN-1229)","Tioxolone"]
[null,"h","Empty","S2182","S2202","S2224","S2246","S2290","S2377","S2397","S2467","S2517","S2606","Empty"]
[{"$nulls":3},"SB743921 HCl","NVP-BHG712","UK 383367","Abiraterone Acetate (CB7630)","Dihydroartemisinin (DHA)","Biochanin A","Palmatine chloride","Famciclovir","Maprotiline HCl","Mifepristone (RU486)"]
[]
[]
[]
[null,"Plate layout: L7100-05"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2617","S2656","S2680","S2699","S2728","S2746","S2761","S2780","S2799","S2818","Empty"]
[{"$nulls":3},"TAK-733","PF-04929113 (SNX-5422)","Ibrutinib (PCI-32765)","CH5132799","AG-1478 (Tyrphostin AG-1478)","AZ 628","NVP-BVU972","I-BET151 (GSK1210151A)","Daporinad","Tacedinaline (CI994)"]
[null,"b","Empty","S2621","S2658","S2683","S2700","S2730","S2747","S2768","S2783","S2801","S2819","Empty"]
[{"$nulls":3},"AZD5438","Omipalisib (GSK2126458)","CHIR-124","Tirbanibulin","Crenolanib (CP-868596)","AMG-458","Dinaciclib (SCH727965)","Vistusertib (AZD2014)","AZD4547","AM251"]
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[{"$nulls":3},"PP121","WYE-125132 (WYE-132)","KW-2478","GSK1838705A","AZ 3146","BGT226 (NVP-BGT226) maleate","MK-5108 (VX-689)","TAK-285","Galeterone","TAE226 (NVP-TAE226)"]
[null,"d","Empty","S2624","S2662","S2688","S2711","S2736","S2750","S2772","S2785","S2806","S2821","Empty"]
[{"$nulls":3},"OSI-027","Foscenvivint (ICG-001)","R547","Dibenzazepine (YO-01027)","Fedratinib (TG101348)","GW788388","Dalcetrapib (JTT-705)","A-803467","CEP-33779","RG108"]
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[{"$nulls":3},"Rabusertib (LY2603618)","Ciprofibrate","WAY-600","TAK-901","GSK1070916","Milciclib (PHA-848125)","MK-2461","Istradefylline","Ipatasertib (GDC-0068)","Tideglusib (NP031112)"]
[null,"f","Empty","S2630","S2666","S2692","S2719","S2742","S2753","S2775","S2792","S2811","S2824","Empty"]
[{"$nulls":3},"GW3965 HCl","PF-3845","TG101209","AMG-900","PHA-767491 HCl","Tivantinib (ARQ 197)","Nocodazole (R17934)","Torcetrapib","Sapanisertib (MLN0128)","TPCA-1"]
[null,"g","Empty","S2635","S2670","S2693","S2722","S2743","S2757","S2778","S2796","S2814","S2825","Empty"]
[{"$nulls":3},"CCT128930","A-674563","Resminostat","JTC-801","PF-04691502","Evofosfamide (TH-302)","GW842166X","WP1066","Alpelisib (BYL719)","ML133 HCl"]
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[{"$nulls":3},"SNX-2112 (PF-04928473)","Trametinib (GSK1120212)","Apitolisib (GDC-0980)","Dacomitinib (PF-00299804)","CHIR-98014","Fimepinostat (CUDC-907)","M344","Lonafarnib (SCH66336)","Torin 2","SAR131675"]
[]
[]
[]
[null,"Plate layout: L7100-06"]
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[{"$nulls":3},"BI-D1870","IKK-16 (IKK Inhibitor VII)","PF-477736","Pazopanib","Azilsartan Medoxomil","Spermidine trihydrochloride","Nordihydroguaiaretic acid (NDGA)","Nafcillin Sodium","Halobetasol Propionate","Azithromycin Dihydrate"]
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[{"$nulls":3},"Semaxanib (SU5416)","Acesulfame Potassium","BAY 11-7082","Aspirin (NSC 27223)","Beclomethasone dipropionate","Fludrocortisone acetate","Theophylline-7-acetic acid","Pheniramine Maleate","Difluprednate","Amfenac Sodium Monohydrate"]
[null,"c","Empty","S2853","S2891","S2914","S3019","S3081","S3665","S4001","S4046","S4098","S4151","Empty"]
[{"$nulls":3},"Carfilzomib (PR-171)","GW441756","Dapivirine (TMC120)","Ciclopirox ethanolamine","Ulipristal Acetate (CDB 2914)","Trolox","Cabozantinib malate","Estradiol Cypionate","Halcinonide","Penfluridol"]
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[{"$nulls":3},"StemRegenin 1 (SR1)","VU 0361737","PF-4981517","Cabazitaxel (XRP6258)","Nadifloxacin","Carmustine","Pentamidine isethionate","Bisacodyl","Eprosartan Mesylate","Benzethonium Chloride"]
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[{"$nulls":3},"Golvatinib (E7050)","Tyrphostin 9","Icotinib (BPI-2009H)","Fenoprofen calcium hydrate","Dexamethasone Acetate","Tipiracil hydrochloride","Ampiroxicam","Zinc Pyrithione","Clofazimine","Benzydamine HCl"]
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[{"$nulls":3},"IEM 1754 2HBr","ZM 306416","Laduviglusib (CHIR-99021) HCl","Niclosamide (BAY2353)","Darifenacin HBr","Quinidine hemisulfate hydrate","Avanafil","Mefenamic Acid","Estradiol Benzoate","Chlorpropamide"]
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[{"$nulls":3},"VU 0364770","Cobicistat (GS-9350)","Evacetrapib (LY2484595)","Bindarit (AF 2838)","Anagrelide HCl","(-)-Arctigenin","Diphemanil Methylsulfate","Triamterene","Triclabendazole","Cyromazine"]
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[{"$nulls":3},"WHI-P154","CCG 50014","TAK-715","Daunorubicin (RP 13057) HCl","Triptolide (PG490)","Hydroxy Camptothecine","Norethindrone","Flumethasone","Sulconazole Nitrate","Teriflunomide"]
[]
[]
[]
[null,"Plate layout: L7100-07"]
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[{"$nulls":3},"Cetylpyridinium Chloride","Valnemulin HCl","Epinastine HCl","Isoetharine Mesylate","Bendroflumethiazide","Hexylresorcinol","Atipamezole","Trapidil","SN-38","Mephenesin"]
[null,"b","Empty","S4186","S4223","S4260","S4334","S4394","S4576","S4667","S4817","S4921","S5033","Empty"]
[{"$nulls":3},"Domiphen Bromide","Mevastatin","Tamibarotene","Mesoridazine Besylate","Clofoctol","Sulfabenzamide","Lidocaine hydrochloride","Atenolol","MNS (3,4-Methylenedioxy-β-nitrostyrene)","Terconazole"]
[null,"c","Empty","S4192","S4224","S4268","S4336","S4396","S4578","S4669","S4836","S4957","S5049","Empty"]
[{"$nulls":3},"Chlorquinaldol","Erythritol","Flufenamic acid","Metaraminol Bitartrate","Digoxigenin","Tyloxapol","Benzocaine hydrochloride","Nilutamide","Linalool","Thiocolchicoside"]
[null,"d","Empty","S4195","S4225","S4269","S4344","S4406","S4583","S4697","S4849","S4977","S5062","Empty"]
[{"$nulls":3},"Broxyquinoline","Mexiletine HCl","Vinorelbine ditartrate (KW-2307)","Oxprenolol HCl","Pindolol","Butamben","Saxagliptin hydrate","Levocetirizine Dihydrochloride","Efonidipine","Daclatasvir Dihydrochloride"]
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[{"$nulls":3},"Ethacridine lactate monohydrate","Pilocarpine HCl","Oxiracetam","Terfenadine","Eltrombopag","Mebendazole","Palmitoylethanolamide","Iproniazid","4-Butylresorcinol","Dabrafenib Mesylate"]
[null,"f","Empty","S4201","S4232","S4288","S4354","S4505","S4635","S4709","S4900","S5006","S5077","Empty"]
[{"$nulls":3},"Florfenicol","Nithiamide","Chloroambucil","Thiostrepton","Vinblastine (NSC-49842) sulfate","Cyproheptadine hydrochloride sesquihydrate","Latanoprost","Tenovin-6","Teprenone","Regorafenib (BAY-734506) Monohydrate"]
[null,"g","Empty","S4208","S4237","S4303","S4367","S4506","S4641","S4727","S4902","S5012","S5078","Empty"]
[{"$nulls":3},"Chromocarb","Primaquine Diphosphate","9-Aminoacridine","Suxibuzone","Acetazolamide","Tedizolid Phosphate","Cinnarizine","QNZ (EVP4593)","Octenidine Dihydrochloride","Osimertinib mesylate"]
[null,"h","Empty","S4213","S4243","S4316","S4373","S4546","S4646","S4735","S4904","S5029","S5141","Empty"]
[{"$nulls":3},"Dirithromycin","Deoxycorticosterone acetate","Clopamide","Dicyclomine HCl","Xylitol","Ciclesonide","Salvianolic acid B","JZL184","Etofylline","Pyrithioxin"]
[]
[]
[]
[null,"Plate layout: L7100-08"]
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[{"$nulls":3},"Naproxen","Cediranib Maleate","Ramatroban","D-Tagatose","7-Nitroindazole","Amsacrine hydrochloride","Atorvastatin","Vanoxerine dihydrochloride","K 858","Apilimod (STA-5326)"]
[null,"b","Empty","S5200","S5243","S5297","S5392","S5554","S5651","S5716","S5806","S5939","S6438","Empty"]
[{"$nulls":3},"Diaveridine","Ruxolitinib Phosphate","Vidarabine monohydrate","Mepivacaine","Lanatoside C","Dexrazoxane","Abemaciclib (LY2835219)","Cilostamide","Bendamustine (SDX105)","Ufiprazole"]
[null,"c","Empty","S5205","S5247","S5298","S5416","S5564","S5662","S5735","S5812","S6005","S6441","Empty"]
[{"$nulls":3},"Nilotinib hydrochloride","Selamectin","Amoxicillin trihydrate","Metyrapone","Xylazine","Ranitidine","Midodrine","Choline Fenofibrate","VX-702","Riboflavin Tetrabutyrate"]
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[{"$nulls":3},"Sulfamethazine Sodium Salt","Dasatinib hydrochloride","Nitisinone","Hyperoside","Tilmicosin phosphate","Isoxsuprine hydrochloride","Baricitinib phosphate","cariporide","Doxycycline monohydrate","Clebopride malate"]
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[{"$nulls":3},"Fenretinide (NSC 374551)","Canrenone","Metroprolol succinate","Fluorometholone","Cytarabine hydrochloride","Chloropyramine hydrochloride","Prazosin","Palifosfamide","Picolinic acid (PCL 016)","uridine triacetate"]
[null,"f","Empty","S5234","S5278","S5353","S5491","S5606","S5686","S5781","S5863","S6288","S6509","Empty"]
[{"$nulls":3},"Nintedanib Ethanesulfonate Salt","Tedizolid (TR-700)","Cefpiramide sodium","Lomefloxacin","Sulfamide","Tryptanthrin","Raloxifene","Metronidazole Benzoate","Chlorhexidine diacetate","AG 494"]
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[{"$nulls":3},"Lenvatinib (E7080) Mesylate","Fendiline hydrochloride","Alogliptin","Trimebutine maleate","Chicago Sky Blue 6B","Norgestrel","Dronedarone","Estradiol dipropionate","Zucapsaicin","JK184"]
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[{"$nulls":3},"Lapatinib ditosylate monohydrate","RU58841","Ajmaline","Tropisetron","Ammonium lactate","lurasidone","Motesanib (AMG-706)","Rabeprazole Related Compound E","Nimorazole","Hydrocortisone butyrate"]
[]
[]
[]
[null,"Plate layout: L7100-09"]
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[{"$nulls":3},"(±)-Equol","Embelin","Tezacaftor (VX-661)","Berzosertib (VE-822)","PR-619","Batimastat (BB-94)","RKI-1447","RGFP966","SGI-1027","PJ34 HCl"]
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[{"$nulls":3},"Binimetinib (MEK162)","AZD2461","LY2090314","Taselisib (GDC 0032)","P5091 (P005091)","Marimastat (BB-2516)","Idasanutlin (RG-7388)","Bromosporine","JIB-04","BAY 87-2243"]
[null,"c","Empty","S7009","S7033","S7065","S7106","S7133","S7157","S7206","S7251","S7282","S7316","Empty"]
[{"$nulls":3},"LCL161","GSK2656157","MK-8745","AZD3463","P22077","Ilomastat","CNX-2006","KPT-276","NMS-E973","STF-118804"]
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[{"$nulls":3},"GDC-0152","PD168393","GSK J4 HCl (GSKJ4 HCl)","(+)-JQ1","LDN-57444","Spebrutinib (CC-292)","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","Selinexor (KPT-330)","Rociletinib (CO-1686)","Tasisulam"]
[null,"e","Empty","S7014","S7046","S7090","S7114","S7142","S7176","S7209","S7253","S7285","S7329","Empty"]
[{"$nulls":3},"Merestinib (LY2801653)","Brefeldin A","GSK923295","NU6027","NSC697923","SKI II","GSK650394","AZD2858","NMS-873","IOWH032"]
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[{"$nulls":3},"Birinapant (TL32711)","Oprozomib (ONX 0912)","PF-3758309","XL888","DMH1","Molibresib (I-BET-762)","Skepinone-L","CNX-774","PFK15","K-Ras(G12C) inhibitor 6"]
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[{"$nulls":3},"VS-5584 (SB2343)","AZ20","KY02111","SC144","LDN-212854","1-Azakenpaullone","Alvelestat (AZD9668)","Beta-Lapachone","TAK-632","Bay 11-7085"]
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[{"$nulls":3},"Stattic","LY2874455","(-)-Blebbistatin","KPT-185","NSC 319726","Olverembatinib dimesylate (HQP1351)","RepSox (E-616452)","Golgicide A","RG2833 (RGFP109)","PF-562271 HCl"]
[]
[]
[]
[null,"Plate layout: L7100-10"]
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[{"$nulls":3},"Poziotinib (HM781-36B)","Caffeic Acid Phenethyl Ester","LB42708","Afuresertib (GSK2110183)","Cerdulatinib (PRT062070) hydrochloride","Dovitinib (TKI258) Lactate monohydrate","Ulixertinib (BVD-523)","TIC10 (ONC201)","VE-821","Cobimetinib (GDC-0973)"]
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[{"$nulls":3},"Birabresib (OTX015)","Puromycin (CL13900) 2HCl","Triapine","Entospletinib (GS-9973)","D 4476","Elacridar (GF120918)","Dibutyryl-cAMP (Bucladesine)","Favipiravir (T-705)","Agerafenib (RXDX-105)","Scriptaid"]
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[{"$nulls":3},"4E1RCat","NH125","Nexturastat A","Lorlatinib (PF-6463922)","Pilaralisib (XL147)","Sunitinib (SU11248)","Oltipraz","Napabucasin (BBI608)","Capivasertib (AZD5363)","BMS-345541"]
[null,"d","Empty","S7381","S7440","S7488","S7539","S7646","S7783","S7875","S7999","S8024","S8048","Empty"]
[{"$nulls":3},"Pepstatin A","Ribociclib (LEE011)","MPI-0479605","PTC-209 HBr","Voxtalisib (XL765)","Combretastatin A4","NVP-CGM097","SKF96365","Tyrphostin AG 1296","Venetoclax (ABT-199)"]
[null,"e","Empty","S7392","S7447","S7492","S7573","S7651","S7786","S7917","S8001","S8031","S8050","Empty"]
[{"$nulls":3},"Loxistatin Acid (E-64C)","ZLN005","Uprosertib (GSK2141795)","GSK2830371","SB225002","Erlotinib (OSI-774)","Kenpaullone","Ricolinostat (ACY-1215)","NSC 23766","ETP-46464"]
[null,"f","Empty","S7397","S7451","S7505","S7605","S7653","S7787","S7924","S8003","S8032","S8057","Empty"]
[{"$nulls":3},"Sorafenib (BAY 43-9006)","FPH1 (BRD-6125)","(S)-crizotinib","Filgotinib (GLPG0634)","PND-1186 (VS-4718)","Docetaxel Trihydrate","Bay K 8644","PQ 401","PRT062607 (P505-15) HCl","Pacritinib (SB1518)"]
[null,"g","Empty","S7399","S7458","S7516","S7625","S7741","S7810","S7935","S8005","S8039","S8058","Empty"]
[{"$nulls":3},"FLI-06","VER-49009","Y-320","Niraparib (MK-4827) tosylate","SB239063","Afatinib (BIBW2992) Dimaleate","Y-39983 HCl","SMI-4a","Zelavespib (PU-H71)","Riviciclib hydrochloride (P276-00)"]
[null,"h","Empty","S7409","S7466","S7520","S7633","S7754","S7828","S7936","S8006","S8040","S8065","Empty"]
[{"$nulls":3},"Anisomycin","GGTI 298 TFA salt","Darapladib (SB-480848)","Lomitapide Mesylate","Gilteritinib (ASP2215)","Licochalcone A","Belumosudil (KD025)","BIX 01294","GDC-0349","Nutlin-3b"]
[]
[]
[]
[null,"Plate layout: L7100-11"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S8077","S8238","S8639","S9463","S6626","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"RI-1","SB366791","Diphenyleneiodonium chloride (DPI)","Demecarium Bromide","Brequinar (DUP785)"]
[null,"b","Empty","S8078","S8244","S8699","S9507","S9015","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Bardoxolone Methyl","Etomoxir sodium salt","SNS-314 Mesylate","(−)-Norepinephrine","Homoharringtonine (CGX-635)"]
[null,"c","Empty","S8104","S8322","S8736","S4421","S9110","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"SCH58261","Samotolisib (LY3023414)","Verinurad (RDEA3170)","Josamycin","Morin"]
[null,"d","Empty","S8133","S8401","S9063","S6546","S7654","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Resiquimod (R-848)","Erdafitinib (JNJ-42756493)","Harringtonine","PD153035","Defactinib (VS-6063)"]
[null,"e","Empty","S8135","S8419","S9132","S6589","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Riociguat (BAY 63-2521)","Stenoparib (E7449)","Harpagide","Norethisterone Enanthate"]
[null,"f","Empty","S8144","S8558","S9249","S6593","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Halofuginone","Tofogliflozin(CSG 452)","Securinine","Methylprednisolone sodium succinate"]
[null,"g","Empty","S8201","S8567","S9265","S6619","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"BI-78D3","Tucidinostat (Chidamide)","7-Epitaxol","ABT 702 dihydrochloride"]
[null,"h","Empty","S8219","S8615","S9321","S6625","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Bitopertin","Sodium dichloroacetate (DCA)","Topotecan","Temsavir (BMS-626529)"]
[]
[]
[]
[null,"Plate layout: L7100-12"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1375","S4144","S8501","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Dorzolamide HCl","Amprolium HCl","Adaptavir (DAPTA)"]
[null,"b","Empty","S1516","S4236","P1011","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Cidofovir","Proflavine Hemisulfate","Eptifibatide Acetate"]
[null,"c","Empty","S1579","S5097","S3076","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Palbociclib (PD0332991) Isethionate","Methotrexate disodium","Foscarnet Sodium"]
[null,"d","Empty","S1853","S5136","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Penicillamine","Calcium folinate"]
[null,"e","Empty","S2048","S5267","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Clindamycin Phosphate","Nylidrin Hydrochloride"]
[null,"f","Empty","S2129","S5524","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Fudosteine","Spermine Tetrahydrochloride"]
[null,"g","Empty","S2527","S6023","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Methacycline HCl","Creatine monohydrate"]
[null,"h","Empty","S4127","S7204","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Terbutaline Sulfate","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium"]
[]
[]
[]
[null,"Plate layout: L7100-13"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1019","S1519","S2150","S2735","S4642","S5098","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Canertinib (CI-1033)","CCT129202","Neratinib (HKI-272)","MK-8776 (SCH 900776)","Dolutegravir Sodium","Gefitinib hydrochloride"]
[null,"b","Empty","S1043","S1642","S2395","S2744","S5232","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Tandutinib (MLN518)","Methyldopa","Rheochrysidin","CCT137690","Alectinib (CH5424802) hydrochloride"]
[null,"c","Empty","S1046","S1698","S2476","S2805","S7035","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)","Torsemide","Itraconazole (R 51211)","LY364947","XL388"]
[null,"d","Empty","S1108","S1707","S2530","S2827","S7105","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"TAE684 (NVP-TAE684)","Eplerenone (CGP 30083)","7-Aminocephalosporanic acid","Torin 1","BAM7"]
[null,"e","Empty","S1205","S1837","S2597","S2870","S7128","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"PIK-75 HCl","Flubendazole","Oseltamivir Phosphate","TG100713","Tazemetostat (EPZ-6438)"]
[null,"f","Empty","S1211","S1851","S2628","S2920","S7342","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Imiquimod (R-837)","Oxibendazole","Gedatolisib (PKI-587)","Mozavaptan","UNC2250"]
[null,"g","Empty","S1353","S1977","S2684","S3891","S7518","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ketoconazole (R 41400)","Sarafloxacin HCl","Pidnarulex (CX-5461)","Vincamine","Voreloxin (SNS-595) hydrochloride"]
[null,"h","Empty","S1509","S1986","S2704","S4262","S8229","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Norfloxacin","Meclizine 2HCl","LY2109761","Ebastine","Brigatinib (AP26113)"]
[]
[]
[]
[null,"Plate layout: L7100-14"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4226","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Minocycline (CL 59806) HCl"]
[null,"b","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L7100-Broad Institute-897 cpds","index":1,"n_rows":898,"n_cols":23,"rows_kept":898}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1002","ABT-737","a2","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Mitophagy","Apoptosis","ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.",813.43,"852808-04-9",{"v":100,"d":"100.00"},122.94,"<1","N/A","http://selleckchem.com/products/ABT-737.html","C42H45ClN6O5S2","free base","N/A","CN(C)CCC(CSC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[S](=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=C(C=CC=C5)C6=CC=C(Cl)C=C6",8.198,3,2,16]
["S1003","Linifanib (ABT-869)","b2","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,CSF-1R,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.",375.41,"796967-16-3",{"v":75,"d":"75.00"},199.78,"<1","N/A","http://selleckchem.com/products/ABT-869.html","C21H18FN5O","free base","AL39324,RG3635","CC1=CC(=C(F)C=C1)NC(=O)NC2=CC=C(C=C2)C3=C4C(=N[NH]C4=CC=C3)N",4.169,2,4,3]
["S1005","Axitinib (AG 013736)","c2","L7100-01","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.",386.47,"319460-85-0",{"v":35,"d":"35.00"},90.56,"<1","N/A","http://selleckchem.com/products/Axitinib.html","C22H18N4OS","free base","AG 013736","CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=N[NH]3)\\C=C\\C4=CC=CC=N4",4.492,3,2,5]
["S1006","Saracatinib (AZD0530)","d2","L7100-01","in 10mM DMSO","Autophagy,EGFR,Src","Angiogenesis","Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.",542.03,"379231-04-6",{"v":35,"d":"35.00"},64.57,"<1","N/A","http://selleckchem.com/products/AZD0530.html","C27H32ClN5O5","free base","N/A","CN1CCN(CCOC2=CC(=C3C(=NC=NC3=C2)NC4=C(Cl)C=CC5=C4OCO5)OC6CCOCC6)CC1",3.814,7,1,8]
["S1007","Roxadustat (FG-4592)","e2","L7100-01","in 10mM DMSO","Ferroptosis,HIF","Angiogenesis","Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.",352.34,"808118-40-3",{"v":70,"d":"70.00"},198.67,"<1","N/A","http://selleckchem.com/products/fg-4592.html","C19H16N2O5","free base","ASP1517","CC1=NC(=C(O)C2=C1C=C(OC3=CC=CC=C3)C=C2)C(=O)NCC(O)=O",2.306,4,2,5]
["S1008","Selumetinib (AZD6244)","f2","L7100-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It  also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.",457.68,"606143-52-6",{"v":91,"d":"91.00"},198.83,"<1","N/A","http://selleckchem.com/products/AZD6244.html","C17H15BrClFN4O3","free base","ARRY-142886","C[N]1C=NC2=C(F)C(=C(C=C12)C(=O)NOCCO)NC3=CC=C(Br)C=C3Cl",3.234,3,3,6]
["S1013","Bortezomib (PS-341)","g2","L7100-01","in 10mM DMSO","Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome","Proteases","Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.",384.24,"179324-69-7",{"v":76,"d":"76.00"},197.79,"<1","N/A","http://selleckchem.com/products/Bortezomib.html","C19H25BN4O4","Free Base","Velcade, LDP-341, MLM341, NSC 681239,PS-341","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O",2.183,4,2,9]
["S1014","Bosutinib (SKI-606)","h2","L7100-01","in 10mM DMSO","Autophagy,Bcr-Abl,ERK,S6 Kinase,Src,STAT","Angiogenesis","Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.",530.45,"380843-75-4",{"v":100,"d":"100.00"},188.52,"<1","N/A","http://selleckchem.com/products/Bosutinib.html","C26H29Cl2N5O3","free base","SKI-606","COC1=C(Cl)C=C(Cl)C(=C1)NC2=C(C=NC3=CC(=C(OC)C=C23)OCCCN4CCN(C)CC4)C#N",4.883,4,1,9]
["S1020","PD184352 (CI-1040)","a3","L7100-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis.",478.67,"212631-79-3",{"v":96,"d":"96.00"},200.56,"<1","N/A","http://selleckchem.com/products/CI-1040-(PD184352).html","C17H14ClF2IN2O2","free base","N/A","FC1=CC=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl",4.907,2,2,6]
["S1022","Ridaforolimus (Deforolimus, MK-8669)","b3","L7100-01","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.",990.21,"572924-54-0",{"v":198,"d":"198.00"},199.96,"<1","N/A","http://selleckchem.com/products/Deforolimus.html","C53H84NO14P","free base","AP23573","COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.303,12,1,8]
["S1029","Lenalidomide (CC-5013)","c3","L7100-01","in 10mM DMSO","Apoptosis related,Caspase,E3 Ligase ,E3 ligase Ligand,TNF-alpha,VEGFR","Ubiquitin","Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.",259.26,"191732-72-6",{"v":52,"d":"52.00"},200.57,"<1","N/A","https://www.selleckchem.com/products/lenalidomide-s1029.html","C13H13N3O3","free base","CC-5013","NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",-0.515,3,2,1]
["S1030","Panobinostat (LBH589)","d3","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC,HIV Protease","Epigenetics","Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.",349.43,"404950-80-7",{"v":69,"d":"69.00"},197.46,"<1","N/A","http://selleckchem.com/products/LBH-589.html","C21H23N3O2","Free Base","NVP-LBH589","CC1=C(CCNCC2=CC=C(\\C=C\\C(=O)NO)C=C2)C3=C([NH]1)C=CC=C3",3.194,1,3,7]
["S1036","Mirdametinib (PD0325901)","e3","L7100-01","in 10mM DMSO","MEK","MAPK","Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.",482.19,"391210-10-9",{"v":96,"d":"96.00"},199.09,"<1","N/A","http://selleckchem.com/products/PD-0325901.html","C16H14F3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C=C1)F",2.578,2,4,7]
["S1038","PI-103","f3","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.",348.36,"371935-74-9",{"v":24,"d":"24.00"},68.89,"<1","N/A","http://selleckchem.com/products/PI-103.html","C19H16N4O3","free base","N/A","OC1=CC(=CC=C1)C2=NC3=C(OC4=C3C=CC=N4)C(=N2)N5CCOCC5",2.798,5,1,2]
["S1044","Temsirolimus (CCI-779)","g3","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis.",1030.29,"162635-04-3",{"v":67,"d":"67.00"},65.03,"<1","N/A","http://selleckchem.com/products/Temsirolimus.html","C56H87NO16","free base","NSC 683864,CCI-779","COC1CC(CCC1OC(=O)C(C)(CO)CO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.039,12,3,11]
["S1047","Vorinostat (SAHA)","h3","L7100-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1","N/A","http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1048","Tozasertib","a4","L7100-01","in 10mM DMSO","Aurora Kinase,Autophagy,Bcr-Abl,FLT3","Cell Cycle","Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.",464.59,"639089-54-6",{"v":93,"d":"93.00"},200.18,"<1","N/A","http://selleckchem.com/products/VX-680(MK-0457).html","C23H28N8OS","free base","VX-680, MK-0457","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)SC4=CC=C(NC(=O)C5CC5)C=C4",4.445,4,3,7]
["S1049","Y-27632 2HCl","b4","L7100-01","in 10mM DMSO","Autophagy,ROCK","Cell Cycle","Y-27632 2HCl is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",320.26,"129830-38-2",{"v":64,"d":"64.00"},199.84,{"v":14,"d":"14.00"},43.71,"http://selleckchem.com/products/Y-27632.html","C14H21N3O.2HCl","Dihydrochloride","N/A","Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.871,2,2,3]
["S1052","Elesclomol (STA-4783)","c4","L7100-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.",{"v":400.5,"d":"400.50"},"488832-69-5",{"v":80,"d":"80.00"},199.75,"<1","N/A","http://selleckchem.com/products/Elesclomol.html","C19H20N4O2S2","free base","N/A","CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2",2.885,2,2,8]
["S1053","Entinostat (MS-275)","d4","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.",376.41,"209783-80-2",{"v":75,"d":"75.00"},199.25,"<1","N/A","http://selleckchem.com/products/MS-275.html","C21H20N4O3","free base","SNDX-275","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC(=O)OCC3=CN=CC=C3)C=C2",2.071,4,3,7]
["S1056","AC480 (BMS-599626)","e4","L7100-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.",530.55,"714971-09-2",{"v":113,"d":"113.00"},212.99,"<1","N/A","http://selleckchem.com/products/BMS-599626.html","C27H27FN8O3","free base","N/A","CC1=C2[N](C=C1NC(=O)OCC3COCCN3)N=CN=C2NC4=CC5=C(C=C4)[N](CC6=CC=CC(=C6)F)N=C5",3.726,6,3,8]
["S1057","Obatoclax Mesylate (GX15-070)","f4","L7100-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1","N/A","http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","g4","L7100-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,"N/A","N/A","http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1064","Masitinib (AB1010)","h4","L7100-01","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","Masitinib is a novel inhibitor for Kit (c-Kit) and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3.",498.64,"790299-79-5",{"v":100,"d":"100.00"},200.55,"<1","N/A","http://selleckchem.com/products/Masitinib-(AB1010).html","C28H30N6OS","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC(=C(C)C=C3)NC4=NC(=CS4)C5=CC=CN=C5",4.475,3,2,7]
["S1065","Pictilisib (GDC-0941)","a5","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,PI3K","PI3K/Akt/mTOR","Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.",513.64,"957054-30-7",{"v":44,"d":"44.00"},85.66,"<1","N/A","http://selleckchem.com/products/GDC-0941.html","C23H27N7O3S2","free base","RG7321","C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6",2.153,6,1,5]
["S1067","SB431542","b5","L7100-01","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.",384.39,"301836-41-9",{"v":76,"d":"76.00"},197.72,"<1","N/A","http://selleckchem.com/products/SB-431542.html","C22H16N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=NC=CC=C3)C4=CC5=C(OCO5)C=C4",3.447,5,2,4]
["S1069","Luminespib (NVP-AUY922)","c5","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),IGF-1R","Cytoskeletal Signaling","Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.",465.54,"747412-49-3",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/NVP-AUY922.html","C26H31N3O5","free base","AUY-922, VER-52296","CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C",4.069,4,3,7]
["S1070","PHA-665752","d5","L7100-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays,  >50-fold selectivity for c-Met than RTKs or STKs.",641.61,"477575-56-7",{"v":128,"d":"128.00"},{"v":199.5,"d":"199.50"},"<1","N/A","http://selleckchem.com/products/PHA-665752.html","C32H34Cl2N4O4S","free base","N/A","CC1=C(C(=C([NH]1)/C=C/2C(=O)NC3=C2C=C(C=C3)[S](=O)(=O)CC4=C(Cl)C=CC=C4Cl)C)C(=O)N5CCCC5CN6CCCC6",5.689,4,2,7]
["S1071","HA14-1","e5","L7100-01","in 10mM DMSO","Bcl-2","Apoptosis","HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.",409.23,"65673-63-4",{"v":82,"d":"82.00"},200.38,"<1","N/A","http://selleckchem.com/products/HA14-1.html","C17H17BrN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Br",2.511,5,1,7]
["S1072","ZSTK474","f5","L7100-01","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2.",417.41,"475110-96-4",{"v":21,"d":"21.00"},50.31,"<1","N/A","http://selleckchem.com/products/ZSTK474.html","C19H21F2N7O2","free base","N/A","FC(F)C1=NC2=C(C=CC=C2)[N]1C3=NC(=NC(=N3)N4CCOCC4)N5CCOCC5",3.366,6,0,4]
["S1078","MK-2206 2HCl","g5","L7100-01","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.",480.39,"1032350-13-2",{"v":14,"d":"14.00"},29.14,"<1","N/A","http://selleckchem.com/products/MK-2206.html","C25H21N5O.2HCl","Dihydrochloride","N/A","Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6",4.183,3,2,3]
["S1082","Vismodegib (GDC-0449)","h5","L7100-01","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.",{"v":421.3,"d":"421.30"},"879085-55-9",{"v":84,"d":"84.00"},199.38,"<1","N/A","http://selleckchem.com/products/GDC-0449.html","C19H14Cl2N2O3S","free base","GDC-0449","C[S](=O)(=O)C1=CC=C(C(=C1)Cl)C(=O)NC2=CC(=C(Cl)C=C2)C3=NC=CC=C3",4.265,4,1,4]
["S1085","Belinostat (PXD101)","a6","L7100-01","in 10mM DMSO","Autophagy,HDAC","Epigenetics","Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.",318.35,"866323-14-0",{"v":64,"d":"64.00"},201.04,"<1","N/A","http://selleckchem.com/products/Belinostat.html","C15H14N2O4S","free base","PXD101,NSC726630, PX-105684","ONC(=O)/C=C/C1=CC(=CC=C1)[S](=O)(=O)NC2=CC=CC=C2",{"v":1.8,"d":"1.800"},3,2,5]
["S1089","Refametinib (RDEA119)","b6","L7100-01","in 10mM DMSO","MEK","MAPK","Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.",572.34,"923032-37-5",{"v":100,"d":"100.00"},174.72,"<1","N/A","http://selleckchem.com/products/refametinib-rdea119-bay86-9766.html","C19H20F3IN2O5S","free base","Bay 86-9766","COC1=C(N[S](=O)(=O)C2(CC2)CC(O)CO)C(=C(F)C(=C1)F)NC3=CC=C(I)C=C3F",2.827,3,4,9]
["S1090","Abexinostat (PCI-24781)","c6","L7100-01","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.",397.42,"783355-60-2",{"v":80,"d":"80.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/PCI-24781.html","C21H23N3O5","free base","CRA-024781","CN(C)CC1=C(OC2=CC=CC=C12)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO",2.353,4,2,8]
["S1091","Linsitinib (OSI-906)","d6","L7100-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.",421.49,"867160-71-2",{"v":84,"d":"84.00"},199.29,"<1","N/A","http://selleckchem.com/products/OSI-906.html","C26H23N5O","free base","N/A","CC1(O)CC(C1)C2=NC(=C3[N]2C=CN=C3N)C4=CC=C5C=CC(=NC5=C4)C6=CC=CC=C6",3.757,3,1,3]
["S1093","GSK1904529A","e6","L7100-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","GSK1904529A (GSK 4529) is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM in cell-free assays, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.",851.96,"1089283-49-7",{"v":124,"d":"124.00"},145.55,"<1","N/A","http://selleckchem.com/products/GSK1904529A.html","C44H47F2N9O5S","free base","GSK 4529","CCC1=CC(=C(OC)C=C1N2CCC(CC2)N3CCN(CC3)[S](C)(=O)=O)NC4=NC(=CC=N4)C5=C(N=C6C=CC=C[N]56)C7=CC(=C(OC)C=C7)C(=O)NC8=C(F)C=CC=C8F",6.571,8,2,12]
["S1094","PF-04217903","f6","L7100-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1.",372.38,"956905-27-4",{"v":5,"d":"5.00"},13.43,"<1","N/A","http://selleckchem.com/products/PF-04217903.html","C19H16N8O","free base","N/A","OCC[N]1C=C(C=N1)C2=NC3=C(N=C2)N=N[N]3CC4=CC5=CC=CN=C5C=C4",1.561,6,1,5]
["S1095","Dacinostat (LAQ824)","g6","L7100-01","in 10mM DMSO","HDAC,p21","Epigenetics","Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.",379.46,"404951-53-7",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/LAQ824(NVP-LAQ824).html","C22H25N3O3","free base","NVP-LAQ824","OCCN(CCC1=C[NH]C2=C1C=CC=C2)CC3=CC=C(\\C=C\\C(=O)NO)C=C3",3.045,1,3,9]
["S1096","Quisinostat (JNJ-26481585) 2HCl","h6","L7100-01","in 10mM DMSO","HDAC","Epigenetics","Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.",467.39,"875320-31-3",{"v":79,"d":"79.00"},169.02,"<1","N/A","http://selleckchem.com/products/JNJ-26481585.html","C21H28Cl2N6O2","Dihydrochloride","N/A","Cl.Cl.C[N]1C=C(CNCC2CCN(CC2)C3=NC=C(C=N3)C(=O)NO)C4=CC=CC=C14",2.749,3,2,6]
["S1100","MLN8054","a7","L7100-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.",476.86,"869363-13-3",{"v":95,"d":"95.00"},199.22,"<1","N/A","http://selleckchem.com/products/MLN8054.html","C25H15ClF2N4O2","free base","N/A","OC(=O)C1=CC=C(NC2=NC3=C(CN=C(C4=CC(=CC=C34)Cl)C5=C(F)C=CC=C5F)C=N2)C=C1",6.192,4,1,4]
["S1101","Vatalanib (PTK787) 2HCl","b7","L7100-01","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Vatalanib 2HCl (PTK787, ZK 222584, cpg-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM in a cell-free assay, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 3.",419.73,"212141-51-0",{"v":85,"d":"85.00"},202.51,{"v":10,"d":"10.00"},23.82,"http://selleckchem.com/products/Vatalanib,Dihydrochloride-Salt.html","C20H15ClN4.2HCl","Dihydrochloride","ZK 222584 (cpg-79787) 2HCl","Cl.Cl.ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C24)C=C1",5.469,3,1,4]
["S1103","ZM 447439","c7","L7100-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.",513.59,"331771-20-1",{"v":103,"d":"103.00"},200.55,"<1","N/A","http://selleckchem.com/products/ZM-447439.html","C29H31N5O4","free base","N/A","COC1=C(OCCCN2CCOCC2)C=C3N=CN=C(NC4=CC=C(NC(=O)C5=CC=CC=C5)C=C4)C3=C1",4.118,6,2,10]
["S1104","GDC-0879","d7","L7100-01","in 10mM DMSO","Raf","MAPK","GDC-0879 (AR-00341677) is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well; no inhibition known to other protein kinases.",334.37,"905281-76-7",{"v":66,"d":"66.00"},197.39,"<1","N/A","http://selleckchem.com/products/GDC-0879.html","C19H18N4O2","free base","AR-00341677","OCC[N]1C=C(C2=CC=C\\3C(=C2)CCC3=N\\O)C(=N1)C4=CC=NC=C4",2.387,3,1,4]
["S1106","OSU-03012 (AR-12)","e7","L7100-01","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.",460.45,"742112-33-0",{"v":11,"d":"11.00"},23.89,"<1","N/A","http://selleckchem.com/products/OSU-03012.html","C26H19F3N4O","free base","N/A","NCC(=O)NC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC4=C(C=C3)C5=C(C=CC=C5)C=C4)C(F)(F)F",5.212,2,2,5]
["S1107","Danusertib (PHA-739358)","f7","L7100-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,Bcr-Abl,c-RET,FGFR,Trk receptor","Cell Cycle","Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.",474.55,"827318-97-8",{"v":95,"d":"95.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHA-739358(Danusertib).html","C26H30N6O3","free base","N/A","COC(C(=O)N1CC2=C(C1)C(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CCN(C)CC4)C5=CC=CC=C5",2.337,4,2,6]
["S1109","BI 2536","g7","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Myc,PLK","Cell Cycle","BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.",521.66,"755038-02-9",{"v":21,"d":"21.00"},40.26,"<1","N/A","http://selleckchem.com/products/BI-2536.html","C28H39N7O3","free base","N/A","CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5",3.548,5,2,7]
["S1111","Foretinib (GSK1363089)","h7","L7100-01","in 10mM DMSO","c-Kit,c-Met,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Foretinib (GSK1363089, EXEL-2880, XL-880, GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.",632.65,"849217-64-7",{"v":100,"d":"100.00"},158.07,"<1","N/A","http://selleckchem.com/products/XL880(GSK1363089,EXEL-2880).html","C34H34F2N4O6","free base","EXEL-2880, XL-880, GSK089","COC1=CC2=C(C=C1OCCCN3CCOCC3)N=CC=C2OC4=C(F)C=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4",4.437,7,2,12]
["S1115","Odanacatib (MK-0822)","a8","L7100-01","in 10mM DMSO","Cysteine Protease","Proteases","Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.",525.56,"603139-19-1",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/Odanacatib-(MK0822).html","C25H27F4N3O3S","free base","N/A","CC(C)(F)CC(NC(C1=CC=C(C=C1)C2=CC=C(C=C2)[S](C)(=O)=O)C(F)(F)F)C(=O)NC3(CC3)C#N",3.978,3,2,10]
["S1120","Everolimus (RAD001)","b8","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1","N/A","http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1121","TW-37","c8","L7100-01","in 10mM DMSO","Bcl-2","Apoptosis","TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.",{"v":573.7,"d":"573.70"},"877877-35-5",{"v":115,"d":"115.00"},200.45,"<1","N/A","http://selleckchem.com/products/TW-37.html","C33H35NO6S","free base","N/A","CC(C)C1=CC=CC=C1CC2=CC(=C(O)C(=C2O)O)C(=O)NC3=CC=C(C=C3)[S](=O)(=O)C4=C(C=CC=C4)C(C)(C)C",{"v":7.56,"d":"7.560"},3,4,8]
["S1122","Mocetinostat (MGCD0103)","d8","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.",396.44,"726169-73-9",{"v":13,"d":"13.00"},32.79,"<1","N/A","http://selleckchem.com/products/MGCD0103(Mocetinostat).html","C23H20N6O","free base","MG0103","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC3=NC=CC(=N3)C4=CC=CN=C4)C=C2",2.798,4,3,6]
["S1124","BMS-754807","e8","L7100-01","in 10mM DMSO","c-Met,IGF-1R,RON,Trk receptor","Protein Tyrosine Kinase","BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.",461.49,"1001350-96-4",{"v":92,"d":"92.00"},199.35,"<1","N/A","http://selleckchem.com/products/BMS-754807.html","C23H24FN9O","free base","N/A","CC1(CCCN1C2=N[N]3C=CC=C3C(=N2)NC4=N[NH]C(=C4)C5CC5)C(=O)NC6=CC=C(F)N=C6",4.069,5,3,6]
["S1129","SRT1720 HCl","f8","L7100-01","in 10mM DMSO","Autophagy,Sirtuin","Epigenetics","SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.",506.02,"1001645-58-4",{"v":38,"d":"38.00"},{"v":75.1,"d":"75.10"},"<1","N/A","http://selleckchem.com/products/SRT1720.html","C25H23N7OS.HCl","Hydrochloride","N/A","Cl.O=C(NC1=CC=CC=C1C2=C[N]3C(=CSC3=N2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5",3.018,4,2,5]
["S1130","Sepantronium Bromide","g8","L7100-01","in 10mM DMSO","Autophagy,IAP,Survivin","Apoptosis","Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.",443.29,"781661-94-7",{"v":55,"d":"55.00"},124.07,{"v":89,"d":"89.00"},200.77,"http://selleckchem.com/products/YM155.html","C20H19BrN4O3","Bromide","YM155","[Br-].COCC[N]1C(=[N+](CC2=CN=CC=N2)C3=C1C(=O)C4=C(C=CC=C4)C3=O)C",-0.733,5,0,5]
["S1132","3-Aminobenzamide","h8","L7100-01","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.",136.15,"3544-24-9",{"v":27,"d":"27.00"},198.31,"<1","N/A","https://www.selleckchem.com/products/3-aminobenzamide.html","C7H8N2O","free base","3-ABA , 3-amino Benzamide, 3-AB","NC(=O)C1=CC(=CC=C1)N",0.085,1,2,1]
["S1133","Alisertib (MLN8237)","a9","L7100-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy","Cell Cycle","Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.",518.92,"1028486-01-2",{"v":27,"d":"27.00"},52.03,"<1","N/A","http://selleckchem.com/products/MLN8237.html","C27H20ClFN4O4","free base","N/A","COC1=C(C(=CC=C1)F)C2=NCC3=C(N=C(NC4=CC(=C(C=C4)C(O)=O)OC)N=C3)C5=C2C=C(Cl)C=C5",5.954,6,1,6]
["S1134","AT9283","b9","L7100-01","in 10mM DMSO","Aurora Kinase,Bcr-Abl,JAK","JAK/STAT","AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I).",381.43,"896466-04-9",{"v":76,"d":"76.00"},199.25,"<1","N/A","http://selleckchem.com/products/AT9283.html","C19H23N7O2","free base","N/A","O=C(NC1CC1)NC2=C[NH]N=C2C3=NC4=CC(=CC=C4[NH]3)CN5CCOCC5",{"v":1.51,"d":"1.510"},4,4,5]
["S1141","Tanespimycin (17-AAG)","c9","L7100-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),Mitophagy","Cytoskeletal Signaling","Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.",585.69,"75747-14-7",{"v":100,"d":"100.00"},170.74,"<1","N/A","http://selleckchem.com/products/17-AAG(Geldanamycin).html","C31H43N3O8","free base","CP127374, NSC-330507, KOS 953","COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.524,7,4,7]
["S1142","Alvespimycin (17-DMAG) HCl","d9","L7100-01","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay.",653.21,"467214-21-7",{"v":131,"d":"131.00"},200.55,"<1","N/A","http://selleckchem.com/products/17-DMAG,Hydrochloride-Salt.html","C32H48N4O8.HCl","Hydrochloride","NSC 707545,BMS 826476 HCl,KOS 1022","Cl.COC1CC(C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.428,7,4,8]
["S1145","SNS-032 (BMS-387032)","e9","L7100-01","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.",380.53,"345627-80-7",{"v":76,"d":"76.00"},199.72,"<1","N/A","http://selleckchem.com/products/SNS-032.html","C17H24N4O2S2","free base","N/A","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1",{"v":2.07,"d":"2.070"},4,2,6]
["S1147","Barasertib (AZD1152-HQPA)","f9","L7100-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.",507.56,"722544-51-6",{"v":102,"d":"102.00"},200.96,"<1","N/A","http://selleckchem.com/products/AZD1152-HQPA.html","C26H30FN7O3","free base","AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib","CCN(CCO)CCCOC1=CC=C2C(=NC=NC2=C1)NC3=CC(=N[NH]3)CC(=O)NC4=CC=CC(=C4)F",3.493,5,4,13]
["S1152","PLX-4720","g9","L7100-01","in 10mM DMSO","Raf","MAPK","PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.",413.83,"918505-84-7",{"v":83,"d":"83.00"},200.57,"<1","N/A","http://selleckchem.com/products/PLX-4720.html","C17H14ClF2N3O3S","free base","N/A","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(Cl)C=C23",3.435,4,2,6]
["S1156","Capecitabine (RO 09-1978)","h9","L7100-01","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis","DNA Damage/DNA Repair","Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.",359.35,"154361-50-9",{"v":72,"d":"72.00"},200.36,{"v":6,"d":"6.00"},{"v":16.7,"d":"16.70"},"http://selleckchem.com/products/Capecitabine(Xeloda).html","C15H22FN3O6","free base","RO 09-1978","CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2OC(C)C(O)C2O",{"v":0.82,"d":"0.820"},5,3,7]
["S1157","Delanzomib (CEP-18770)","a10","L7100-01","in 10mM DMSO","Proteasome","Proteases","Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2.",413.28,"847499-27-8",{"v":83,"d":"83.00"},200.83,"<1","N/A","http://selleckchem.com/products/cep-18770.html","C21H28BN3O5","free base","N/A","CC(C)C(CNC(=O)C(NC(=O)C1=NC(=CC=C1)C2=CC=CC=C2)C(C)O)B(O)O",2.646,3,3,9]
["S1158","MK-8245","b10","L7100-01","in 10mM DMSO","SCD","Metabolism","MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.",467.25,"1030612-90-8",{"v":93,"d":"93.00"},199.04,"<1","N/A","http://selleckchem.com/products/mk-8245.html","C17H16BrFN6O4","free base","N/A","OC(=O)C[N]1N=NC(=N1)C2=CC(=NO2)N3CCC(CC3)OC4=CC(=CC=C4Br)F",2.991,7,0,6]
["S1159","Ganetespib (STA-9090)","c10","L7100-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.",{"v":364.4,"d":"364.40"},"888216-25-9",{"v":40,"d":"40.00"},109.77,"<1","N/A","http://selleckchem.com/products/ganetespib-sta-9090.html","C20H20N4O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)[N](C)C=C4",3.866,2,3,3]
["S1163","Onalespib (AT13387)","d10","L7100-01","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.",409.52,"912999-49-6",{"v":25,"d":"25.00"},61.05,"<1","N/A","http://selleckchem.com/products/at13387.html","C24H31N3O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C(=O)N2CC3=C(C2)C=C(CN4CCN(C)CC4)C=C3",3.322,1,2,4]
["S1165","ABT-751 (E7010)","e10","L7100-01","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.",371.41,"141430-65-1",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/ABT-751.html","C18H17N3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(NC3=CC=C(O)C=C3)N=CC=C2",2.997,4,3,6]
["S1167","CP-724714","f10","L7100-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.",469.53,"537705-08-1",{"v":94,"d":"94.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://selleckchem.com/products/CP-724714.html","C27H27N5O3","free base","N/A","COCC(=O)NC/C=C/C1=CC=C2N=CN=C(NC3=CC=C(OC4=CC=C(C)N=C4)C(=C3)C)C2=C1",3.987,6,2,9]
["S1170","WZ3146","g10","L7100-01","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).",464.95,"1214265-56-1",{"v":93,"d":"93.00"},200.02,"<1","N/A","http://selleckchem.com/products/WZ3146.html","C24H25ClN6O2","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(Cl)C(=N3)OC4=CC(=CC=C4)NC(=O)C=C)C=C2",4.823,4,2,7]
["S1171","CYC116","h10","L7100-01","in 10mM DMSO","Aurora Kinase,VEGFR","Cell Cycle","CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.",368.46,"693228-63-6",{"v":24,"d":"24.00"},65.14,"<1","N/A","http://selleckchem.com/products/CYC116.html","C18H20N6OS","free base","N/A","CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.743,4,2,4]
["S1172","Serdemetan (JNJ-26854165)","a11","L7100-01","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1173","WZ4002","b11","L7100-01","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM in BaF3 cell line; does not inhibit ERBB2 phosphorylation (T798I).",494.18,"1213269-23-8",{"v":13,"d":"13.00"},26.31,"<1","N/A","http://selleckchem.com/products/WZ4002.html","C25H27ClN6O3","free base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)OC3=CC(=CC=C3)NC(=O)C=C)C=CC(=C1)N4CCN(C)CC4",4.807,5,2,8]
["S1175","BIIB021","c11","L7100-01","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.",318.76,"848695-25-0",{"v":64,"d":"64.00"},200.78,"<1","N/A","http://selleckchem.com/products/BIIB021.html","C14H15ClN6O","free base","CNF2024","COC1=C(C)C=NC(=C1C)C[N]2C=NC3=C(Cl)N=C(N)N=C23",2.223,5,1,3]
["S1176","Plinabulin (NPI-2358)","d11","L7100-01","in 10mM DMSO","Microtubule Associated,VDA","Angiogenesis","Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.",336.39,"714272-27-2",{"v":54,"d":"54.00"},160.53,"<1","N/A","http://selleckchem.com/products/NPI-2358.html","C19H20N4O2","free base","N/A","CC(C)(C)C1=C(/C=C/2NC(=O)C(/NC2=O)=C/C3=CC=CC=C3)N=C[NH]1",1.921,3,3,3]
["S1177","PD98059","e11","L7100-01","in 10mM DMSO","AhR,MEK","MAPK","PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.",267.28,"167869-21-8",{"v":14,"d":"14.00"},52.38,"<1","N/A","http://selleckchem.com/products/PD-98059.html","C16H13NO3","free base","N/A","COC1=C(N)C(=CC=C1)C2=CC(=O)C3=CC=CC=C3O2",2.373,3,1,2]
["S1179","WZ8040","f11","L7100-01","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).",481.01,"1214265-57-2",{"v":96,"d":"96.00"},199.58,"<1","N/A","http://selleckchem.com/products/WZ8040.html","C24H25ClN6OS","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(Cl)C(=N3)SC4=CC(=CC=C4)NC(=O)C=C)C=C2",5.381,3,2,7]
["S1186","BIBR 1532","g11","L7100-01","in 10mM DMSO","Apoptosis related,Telomerase","DNA Damage/DNA Repair","BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.",331.36,"321674-73-1",{"v":66,"d":"66.00"},199.18,"<1","N/A","http://selleckchem.com/products/BIBR1532.html","C21H17NO3","free base","N/A","CC(=C\\C(=O)NC1=C(C=CC=C1)C(O)=O)/C2=CC3=CC=CC=C3C=C2",4.067,2,1,4]
["S1188","Anastrozole (ZD-1033)","h11","L7100-01","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Anastrozole (Arimidex,ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.",293.37,"120511-73-1",{"v":59,"d":"59.00"},201.11,"<1","N/A","http://selleckchem.com/products/Anastrozole.html","C17H19N5","free base","Arimidex,ZD-1033","CC(C)(C#N)C1=CC(=CC(=C1)C[N]2C=NC=N2)C(C)(C)C#N",2.965,2,0,4]
["S1191","Fulvestrant (ICI-182780)","a2","L7100-02","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor","Endocrinology & Hormones","Fulvestrant (ICI-182780, ZD 9238, ZM 182780) is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity.",606.77,"129453-61-8",{"v":100,"d":"100.00"},164.81,"<1","N/A","http://selleckchem.com/products/Fulvestrant.html","C32H47F5O3S","free base","ICI-182780, ZD 9238, ZM 182780","CC12CCC3C(C(CCCCCCCCC[S](=O)CCCC(F)(F)C(F)(F)F)CC4=C3C=CC(=C4)O)C1CCC2O",8.437,1,2,15]
["S1192","Raltitrexed","b2","L7100-02","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.",458.49,"112887-68-0",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/Raltitrexed.html","C21H22N4O6S","free base","ZD-1694, ICI-D1694, D1694","CN(CC1=CC2=C(C=C1)N=C(C)NC2=O)C3=CC=C(S3)C(=O)NC(CCC(O)=O)C(O)=O",1.528,5,2,9]
["S1194","CUDC-101","c2","L7100-02","in 10mM DMSO","EGFR,HDAC,HER2","Epigenetics","CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.",434.49,"1012054-59-9",{"v":20,"d":"20.00"},46.03,"<1","N/A","http://selleckchem.com/products/CUDC-101.html","C24H26N4O4","free base","N/A","COC1=CC2=C(C=C1OCCCCCCC(=O)NO)C(=NC=N2)NC3=CC(=CC=C3)C#C",5.376,5,2,11]
["S1196","Exemestane (FCE 24304)","d2","L7100-02","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Exemestane (Aromasin,FCE24304, PNU155971,EXE) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.",{"v":296.4,"d":"296.40"},"107868-30-4",{"v":54,"d":"54.00"},182.19,"<1","N/A","http://selleckchem.com/products/Exemestane.html","C20H24O2","free base","Aromasin,FCE24304, PNU155971,EXE","CC12CCC3C(CC(=C)C4=CC(=O)C=CC34C)C1CCC2=O",3.606,2,0,0]
["S1199","Cladribine (RWJ 26251)","e2","L7100-02","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.",285.69,"4291-63-8",{"v":57,"d":"57.00"},199.52,"<1","N/A","http://selleckchem.com/products/Cladribine.html","C10H12ClN5O3","free base","Leustatin,2-CdA,2-Chloro-2′-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251","NC1=NC(=NC2=C1N=C[N]2C3CC(O)C(CO)O3)Cl",-0.259,4,3,2]
["S1207","Tivozanib (AV-951)","f2","L7100-02","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Tivozanib (AV-951, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.",454.86,"475108-18-0",{"v":20,"d":"20.00"},43.97,"<1","N/A","http://selleckchem.com/products/AV-951.html","C22H19ClN4O5","free base","KRN-951","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)NC4=NOC(=C4)C)C(=C3)Cl",4.039,7,2,6]
["S1208","Doxorubicin (Adriamycin) HCl","g2","L7100-02","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1213","Nelarabine","h2","L7100-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.",297.27,"121032-29-9",{"v":60,"d":"60.00"},201.84,{"v":3,"d":"3.00"},10.09,"http://selleckchem.com/products/Arranon.html","C11H15N5O5","free base","506U78,Arranon","COC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)N",-1.376,5,4,3]
["S1216","PFI-1 (PF-6405761)","a3","L7100-02","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-1 (PF-6405761) is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.",347.39,"1403764-72-6",{"v":69,"d":"69.00"},198.62,"<1","N/A","http://selleckchem.com/products/pfl-1.html","C16H17N3O4S","free base","N/A","COC1=C(C=CC=C1)[S](=O)(=O)NC2=CC=C3NC(=O)N(C)CC3=C2",1.376,4,2,4]
["S1218","Clofarabine","b3","L7100-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.",303.68,"123318-82-1",{"v":60,"d":"60.00"},197.58,"<1","N/A","http://selleckchem.com/products/Clofarabine.html","C10H11ClFN5O3","free base","Clolar","NC1=C2N=C[N](C3OC(CO)C(O)C3F)C2=NC(=N1)Cl",-0.085,4,3,2]
["S1219","YM201636","c3","L7100-02","in 10mM DMSO","Autophagy,PI3K,PIKfyve","PI3K/Akt/mTOR","YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue). YM-201636 suppresses the growth of liver cancer via the induction of autophagy.",467.48,"371942-69-7",{"v":35,"d":"35.00"},74.87,"<1","N/A","http://selleckchem.com/products/ym201636.html","C25H21N7O3","free base","N/A","NC1=CC=C(C=N1)C(=O)NC2=CC=CC(=C2)C3=NC(=C4OC5=NC=CC=C5C4=N3)N6CCOCC6",2.467,7,2,4]
["S1220","OSI-930","d3","L7100-02","in 10mM DMSO","c-Kit,CSF-1R,VEGFR","Protein Tyrosine Kinase","OSI-930 is a potent inhibitor of Kit (c-Kit), KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. Phase 1.",443.44,"728033-96-3",{"v":89,"d":"89.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/OSI-930.html","C22H16F3N3O2S","free base","N/A","FC(F)(F)OC1=CC=C(NC(=O)C2=C(NCC3=CC=NC4=CC=CC=C34)C=CS2)C=C1",6.266,3,2,7]
["S1221","Dacarbazine (NSC-45388)","e3","L7100-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.",182.18,"4342-03-4",{"v":12,"d":"12.00"},65.87,{"v":2,"d":"2.00"},10.98,"http://selleckchem.com/products/Dacarbazine.html","C6H10N6O","free base","DTIC-Dome, Imidazole Carboxamide,NSC-45388","CN(C)N=NC1=C(N=C[NH]1)C(N)=O",-0.344,4,2,3]
["S1223","Epirubicin (IMI 28) HCl","f3","L7100-02","in 10mM DMSO","Apoptosis related,Topoisomerase","DNA Damage/DNA Repair","Epirubicin HCl (Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin induces apoptosis.",579.98,"56390-09-1",{"v":100,"d":"100.00"},172.42,{"v":100,"d":"100.00"},172.42,"http://selleckchem.com/products/Ellence.html","C27H29NO11.HCl","Hydrochloride","Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1225","Etoposide (VP-16)","g3","L7100-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II  inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.",588.56,"33419-42-0",{"v":100,"d":"100.00"},169.91,"<1","N/A","http://selleckchem.com/products/Etopophos.html","C29H32O13","free base","VP-16213,Vepesid,VP-16","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)C6=C2C=C7OCOC7=C6",0.935,10,3,5]
["S1226","KU-0063794","h3","L7100-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.",465.54,"938440-64-3",{"v":16,"d":"16.00"},34.37,"<1","N/A","http://selleckchem.com/products/KU-0063794.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=NC(=NC(=C3C=C2)N4CCOCC4)N5CC(C)OC(C)C5",3.274,6,1,5]
["S1229","Fludarabine Phosphate","a4","L7100-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.",365.21,"75607-67-9",{"v":73,"d":"73.00"},199.88,{"v":2,"d":"2.00"},5.48,"http://selleckchem.com/products/Fludara.html","C10H13FN5O7P","Phosphate","F-ara-A (NSC 312887) Phosphate","NC1=NC(=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O)F",-1.384,5,3,4]
["S1230","Flavopiridol (L86-8275)","b4","L7100-02","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.",401.84,"146426-40-6",{"v":15,"d":"15.00"},37.33,"<1","N/A","http://selleckchem.com/products/Flavopiridol.html","C21H20ClNO5","Free Base","NSC 649890 HCl, HMR-1275, Alvocidib","CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",3.108,2,3,2]
["S1233","2-Methoxyestradiol (2-MeOE2)","c4","L7100-02","in 10mM DMSO","Apoptosis related,Autophagy,HIF,Microtubule Associated","Angiogenesis","2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.",302.41,"362-07-2",{"v":60,"d":"60.00"},198.41,"<1","N/A","http://selleckchem.com/products/2-Methoxyestradiol(2ME2).html","C19H26O3","free base","NSC 659853, 2-ME2","COC1=C(O)C=C2CCC3C(CCC4(C)C(O)CCC34)C2=C1",3.821,1,2,1]
["S1235","Letrozole (CGS 20267)","d4","L7100-02","in 10mM DMSO","Aromatase,Autophagy","Endocrinology & Hormones","Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.",{"v":285.3,"d":"285.30"},"112809-51-5",{"v":57,"d":"57.00"},199.79,"<1","N/A","http://selleckchem.com/products/Letrozole.html","C17H11N5","free base","CGS 20267,Femara, Piroxicam","N#CC1=CC=C(C=C1)C([N]2C=NC=N2)C3=CC=C(C=C3)C#N",2.749,2,0,3]
["S1237","Temozolomide (CCRG 81045)","e4","L7100-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.",194.15,"85622-93-1",{"v":38,"d":"38.00"},195.72,"<1","N/A","http://selleckchem.com/products/Methazolastone.html","C6H6N6O2","free base","NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal","CN1N=NC2=C(N=C[N]2C1=O)C(N)=O",0.052,5,1,1]
["S1245","Latrepirdine 2HCl","f4","L7100-02","in 10mM DMSO","5-HT Receptor,GluR,Histamine Receptor","Neuronal Signaling","Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.",392.37,"97657-92-6",{"v":24,"d":"24.00"},61.17,"<1","N/A","http://selleckchem.com/products/Dimebon.html","C21H25N3.2HCl","Dihydrochloride","N/A","Cl.Cl.CN1CCC2=C(C1)C3=C(C=CC(=C3)C)[N]2CCC4=CC=C(C)N=C4",4.769,1,0,3]
["S1249","JNJ-7706621","g4","L7100-02","in 10mM DMSO","Aurora Kinase,CDK","Cell Cycle","JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.",394.36,"443797-96-4",{"v":79,"d":"79.00"},200.32,"<1","N/A","http://selleckchem.com/products/JNJ-7706621.html","C15H12F2N6O3S","free base","N/A","NC1=NC(=N[N]1C(=O)C2=C(F)C=CC=C2F)NC3=CC=C(C=C3)[S](N)(=O)=O",2.226,5,3,4]
["S1250","Enzalutamide (MDV3100)","h4","L7100-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. Enzalutamide is shown to increase autophagy.",464.44,"915087-33-1",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/MDV3100.html","C21H16F4N4O2S","free base","MDV3100","CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC=C(C#N)C(=C3)C(F)(F)F",4.954,2,1,4]
["S1251","Dienogest","a5","L7100-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.",311.42,"65928-58-7",{"v":62,"d":"62.00"},199.09,"<1","N/A","http://selleckchem.com/products/Dienogest.html","C20H25NO2","free base","STS 557","CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC#N",3.046,1,0,1]
["S1257","Posaconazole (SCH 56592)","b5","L7100-02","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Posaconazole (SCH 56592,POS,Noxafil) is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.",700.78,"171228-49-2",{"v":100,"d":"100.00"},{"v":142.7,"d":"142.70"},"<1","N/A","http://selleckchem.com/products/Posaconazole.html","C37H42F2N8O4","free base","SCH 56592,POS,Noxafil","CCC(C(C)O)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C5)(C[N]6C=NC=N6)C7=CC=C(F)C=C7F)C=C4",5.096,6,1,12]
["S1260","Cinacalcet (AMG-073) HCl","c5","L7100-02","in 10mM DMSO","CaSR","GPCR & G Protein","Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.",393.87,"364782-34-3",{"v":79,"d":"79.00"},200.57,"<1","N/A","http://selleckchem.com/products/Cinacalcet-hydrochloride.html","C22H22F3N.HCl","Hydrochloride","Mimpara, Sensipar,AMG-073","Cl.CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=C2C=CC=C3",6.338,0,1,7]
["S1264","PD173074","d5","L7100-02","in 10mM DMSO","Apoptosis related,FGFR,VEGFR","Angiogenesis","PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.",523.67,"219580-11-7",{"v":100,"d":"100.00"},190.96,"<1","N/A","http://selleckchem.com/products/PD-173074.html","C28H41N7O3","free base","N/A","CCN(CC)CCCCNC1=NC=C2C=C(C(=NC2=N1)NC(=O)NC(C)(C)C)C3=CC(=CC(=C3)OC)OC",4.313,6,3,13]
["S1266","WYE-354","e5","L7100-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",495.53,"1062169-56-5",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/WYE-354.html","C24H29N7O5","free base","N/A","COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5",1.886,8,1,6]
["S1267","Vemurafenib (PLX4032)","f5","L7100-02","in 10mM DMSO","Autophagy,Raf","MAPK","Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.",489.92,"918504-65-1",{"v":97,"d":"97.00"},197.99,"<1","N/A","http://selleckchem.com/products/PLX-4032.html","C23H18ClF2N3O3S","free base","RG7204, RO5185426,PLX4032","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CC=C(Cl)C=C4",4.953,4,2,7]
["S1275","BX-912","g5","L7100-02","in 10mM DMSO","PDK","PI3K/Akt/mTOR","BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.",471.35,"702674-56-4",{"v":94,"d":"94.00"},199.43,"<1","N/A","http://selleckchem.com/products/bx-912.html","C20H23BrN8O","free base","N/A","BrC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCC4=CN=C[NH]4",2.798,4,4,7]
["S1276","Adapalene","h5","L7100-02","in 10mM DMSO","Retinoid Receptor","Metabolism","Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.",412.52,"106685-40-9",{"v":8,"d":"8.00"},19.39,"<1","N/A","http://selleckchem.com/products/Adapalene.html","C28H28O3","free base","CD-271","COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(O)=O)[C]45CC6[CH2][CH](C[CH]([CH2]6)C4)C5",6.279,2,0,4]
["S1278","Altretamine","a6","L7100-02","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.",210.28,"645-05-6",{"v":15,"d":"15.00"},71.33,"<1","N/A","http://selleckchem.com/products/Altretamine.html","C9H18N6","free base","Hexamethylmelamine, NSC13875, ENT50852","CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C",1.995,3,0,3]
["S1280","Amisulpride","b6","L7100-02","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.",369.48,"71675-85-9",{"v":73,"d":"73.00"},197.57,"<1","N/A","http://selleckchem.com/products/Amisulpride.html","C17H27N3O4S","free base","DAN-2163","CCN1CCCC1CNC(=O)C2=CC(=C(N)C=C2OC)[S](=O)(=O)CC",1.127,4,2,7]
["S1287","Bumetanide","c6","L7100-02","in 10mM DMSO","NKCC","Transmembrane Transporters","Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.",364.42,"28395-03-1",{"v":73,"d":"73.00"},200.32,"<1","N/A","http://selleckchem.com/products/Bumetanide.html","C17H20N2O5S","free base","N/A","CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)[S](N)(=O)=O",2.862,4,2,8]
["S1289","Carmofur","d6","L7100-02","in 10mM DMSO","COVID-19,DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.",257.26,"61422-45-5",{"v":52,"d":"52.00"},202.13,"<1","N/A","http://selleckchem.com/products/Carmofur.html","C11H16FN3O3","free base","HCFU","CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O",1.125,3,2,5]
["S1297","Epothilone A","e6","L7100-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.",493.66,"152044-53-6",{"v":99,"d":"99.00"},200.54,"<1","N/A","http://selleckchem.com/products/Epothilone-A.html","C26H39NO6S","free base","N/A","CC1CCCC2OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.574,5,2,2]
["S1299","Floxuridine (NSC 27640)","f6","L7100-02","in 10mM DMSO","Apoptosis related,CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.",246.19,"50-91-9",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/Floxuridine.html","C9H11FN2O5","free base","Deoxyfluorouridine, FUDR,NSC 27640","OCC1OC(CC1O)N2C=C(F)C(=O)NC2=O",-1.775,3,3,2]
["S1315","Ki16425","g6","L7100-02","in 10mM DMSO","LPA Receptor","GPCR & G Protein","Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively, shows no activity at LPA4, LPA5, LPA6.",474.96,"355025-24-0",{"v":94,"d":"94.00"},197.91,"<1","N/A","http://selleckchem.com/products/Ki16425.html","C23H23ClN2O5S","free base","N/A","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(CSCCC(O)=O)C=C2)C3=C(Cl)C=CC=C3",5.043,5,1,10]
["S1319","Costunolide","h6","L7100-02","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.",232.32,"553-21-9",{"v":47,"d":"47.00"},202.31,"<1","N/A","http://selleckchem.com/products/Costunolide.html","C15H20O2","free base","NSC 106404","CC/1=C\\CC\\C(=C\\C2OC(=O)C(=C)C2CC1)C",4.022,2,0,0]
["S1330","Felbamate","a7","L7100-02","in 10mM DMSO","NMDAR","Neuronal Signaling","Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.",238.24,"25451-15-4",{"v":48,"d":"48.00"},201.48,"<1","N/A","http://selleckchem.com/products/Felbamate.html","C11H14N2O4","free base","Felbatol, ADD-03055,W-554","NC(=O)OCC(COC(N)=O)C1=CC=CC=C1",0.984,4,2,7]
["S1351","Ivermectin (MK-933)","b7","L7100-02","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1","N/A","http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1352","TG100-115","c7","L7100-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.",346.34,"677297-51-7",{"v":9,"d":"9.00"},25.99,"<1","N/A","http://selleckchem.com/products/TG100-115.html","C18H14N6O2","free base","N/A","NC1=NC2=NC(=C(N=C2C(=N1)N)C3=CC(=CC=C3)O)C4=CC=CC(=C4)O",2.687,4,4,2]
["S1362","Rigosertib (ON-01910)","d7","L7100-02","in 10mM DMSO","Akt,Apoptosis related,PI3K,PLK","Cell Cycle","Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.",473.47,"1225497-78-8",{"v":95,"d":"95.00"},200.65,{"v":95,"d":"95.00"},200.65,"http://selleckchem.com/products/ON-01910.html","C21H24NNaO8S","Sodium Salt","N/A","[Na+].COC1=CC(=C(\\C=C\\[S](=O)(=O)CC2=CC=C(OC)C(=C2)NCC([O-])=O)C(=C1)OC)OC",0.632,6,1,11]
["S1363","Ki8751","e7","L7100-02","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Ki8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR.",469.41,"228559-41-9",{"v":47,"d":"47.00"},100.13,"<1","N/A","http://selleckchem.com/products/Ki8751.html","C24H18F3N3O4","free base","N/A","COC1=CC2=NC=CC(=C2C=C1OC)OC3=CC=C(NC(=O)NC4=CC=C(F)C=C4F)C(=C3)F",4.853,5,2,6]
["S1364","Patupilone (Epothilone B)","f7","L7100-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.",507.68,"152044-54-7",{"v":102,"d":"102.00"},200.91,"<1","N/A","http://selleckchem.com/products/Epothilone-B.html","C27H41NO6S","free base","EPO906","CC1CCCC2(C)OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.779,5,2,2]
["S1366","BMS-707035","g7","L7100-02","in 10mM DMSO","Integrase","Microbiology","BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.",410.42,"729607-74-3",{"v":38,"d":"38.00"},92.59,"<1","N/A","http://selleckchem.com/products/BMS-707035.html","C17H19FN4O5S","free base","N/A","CN1C(=O)C(=C(N=C1N2CCCC[S]2(=O)=O)C(=O)NCC3=CC=C(F)C=C3)O",0.385,5,2,4]
["S1367","Amonafide","h7","L7100-02","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.",283.33,"69408-81-7",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://selleckchem.com/products/Amonafide.html","C16H17N3O2","free base","NSC308847,AS1413","CN(C)CCN1C(=O)C2=C3C(=CC=C2)C=C(N)C=C3C1=O",1.162,2,1,3]
["S1369","Bafetinib (INNO-406)","a8","L7100-02","in 10mM DMSO","Bcr-Abl","Angiogenesis","Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.",576.62,"859212-16-1",{"v":100,"d":"100.00"},173.42,"<1","N/A","http://selleckchem.com/products/Bafetinib.html","C30H31F3N8O","free base","NS-187","CN(C)C1CCN(C1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CN=C5",4.197,5,2,9]
["S1377","Drospirenone","b8","L7100-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.",366.49,"67392-87-4",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/Drospirenone.html","C24H30O3","free base","ZK 3059","CC12CCC(=O)C=C1C3CC3C4C2CCC5(C)C4C6CC6C57CCC(=O)O7",3.383,3,0,0]
["S1391","Oxcarbazepine","c8","L7100-02","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.",252.27,"28721-07-5",{"v":7,"d":"7.00"},27.75,"<1","N/A","http://selleckchem.com/products/Oxcarbazepine.html","C15H12N2O2","free base","GP47680","NC(=O)N1C2=C(CC(=O)C3=C1C=CC=C3)C=CC=C2",2.131,2,1,0]
["S1392","Pelitinib (EKB-569)","d8","L7100-02","in 10mM DMSO","EGFR,MEK,Src","Protein Tyrosine Kinase","Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Pelitinib (EKB-569) also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282 nM, 800 nM and 1255 nM, respectively. Phase2.",467.92,"257933-82-7",{"v":13,"d":"13.00"},27.78,"<1","N/A","http://selleckchem.com/products/Pelitinib.html","C24H23ClFN5O2","free base","N/A","CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(=C2NC3=CC(=C(F)C=C3)Cl)C#N",4.455,3,2,8]
["S1426","Repaglinide","e8","L7100-02","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Repaglinide (AG-EE 623 ZW) is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.",452.59,"135062-02-1",{"v":91,"d":"91.00"},201.06,"<1","N/A","http://selleckchem.com/products/Repaglinide.html","C27H36N2O4","free base","AG-EE 623 ZW","CCOC1=C(C=CC(=C1)CC(=O)NC(CC(C)C)C2=CC=CC=C2N3CCCCC3)C(O)=O",5.307,3,1,10]
["S1444","Ziprasidone HCl","f8","L7100-02","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.",{"v":449.4,"d":"449.40"},"122883-93-6",{"v":90,"d":"90.00"},200.27,"<1","N/A","http://selleckchem.com/products/Ziprasidone-hydrochloride.html","C21H21ClN4OS.HCl","Hydrochloride","CP-88059","Cl.ClC1=CC2=C(CC(=O)N2)C=C1CCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.641,2,1,4]
["S1452","Ispinesib (SB-715992)","g8","L7100-02","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death.",517.06,"336113-53-2",{"v":103,"d":"103.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Ispinesib-mesilate(SB-715992).html","C30H33ClN4O2","free base","CK0238273","CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4",5.259,3,1,9]
["S1453","Tipifarnib (R115777)","h8","L7100-02","in 10mM DMSO","FTase,Transferase","Metabolism","Tipifarnib (R115777, IND 58359) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.",{"v":489.4,"d":"489.40"},"192185-72-1",{"v":14,"d":"14.00"},28.61,"<1","N/A","http://selleckchem.com/products/Tipifarnib(R115777).html","C27H22Cl2N4O","free base","IND 58359","C[N]1C=NC=C1C(N)(C2=CC=C(Cl)C=C2)C3=CC4=C(C=C3)N(C)C(=O)C=C4C5=CC(=CC=C5)Cl",4.808,2,1,4]
["S1454","PHA-680632","a9","L7100-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","PHA-680632 is a potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.",501.62,"398493-79-3",{"v":100,"d":"100.00"},199.35,"<1","N/A","http://selleckchem.com/products/PHA-680632.html","C28H35N7O2","free base","N/A","CCC1=CC=CC(=C1NC(=O)N2CC3=C(C2)C(=N[NH]3)NC(=O)C4=CC=C(C=C4)N5CCN(C)CC5)CC",4.339,3,3,6]
["S1462","AZD6482","b9","L7100-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.",408.45,"1173900-33-8",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://selleckchem.com/products/azd6482.html","C22H24N4O4","free base","KIN-193","CC(NC1=CC=CC=C1C(O)=O)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.003,4,1,5]
["S1467","Doxercalciferol","c9","L7100-02","in 10mM DMSO","Vitamin","Metabolism","Doxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.",412.65,"54573-75-0",{"v":83,"d":"83.00"},201.14,"<1","N/A","http://selleckchem.com/products/Doxercalciferol(Hectorol).html","C28H44O2","free base","1α-hydroxyvitamin D2","CC(C)C(C)/C=C/C(C)C1CCC2C(/CCCC12C)=C/C=C/3CC(O)CC(O)C3=C",6.337,0,2,5]
["S1468","Alfacalcidol","d9","L7100-02","in 10mM DMSO","Vitamin","Metabolism","Alfacalcidol (1-hydroxycholecalciferol) is a non-selective VDR activator medication.",400.64,"41294-56-8",{"v":80,"d":"80.00"},199.68,"<1","N/A","http://selleckchem.com/products/Alfacalcidol.html","C27H44O2","free base","1-hydroxycholecalciferol","CC(C)CCCC(C)C1CCC2/C(CCCC12C)=C\\C=C3/CC(O)CC(O)C3=C",{"v":6.53,"d":"6.530"},0,2,6]
["S1470","Orantinib (SU6668)","e9","L7100-02","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.",310.35,"252916-29-3",{"v":62,"d":"62.00"},199.77,"<1","N/A","http://selleckchem.com/products/TSU-68(SU6668).html","C18H18N2O3","free base","TSU-68","CC1=C(CCC(O)=O)C(=C([NH]1)/C=C/2C(=O)NC3=CC=CC=C23)C",2.868,2,2,4]
["S1474","GSK429286A","f9","L7100-02","in 10mM DMSO","ROCK","Cell Cycle","GSK429286A (RHO-15) is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.",432.37,"864082-47-3",{"v":87,"d":"87.00"},201.22,"<1","N/A","http://selleckchem.com/products/GSK429286A.html","C21H16F4N4O2","free base","RHO-15","CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(F)C=C4[NH]N=CC4=C3",3.033,3,3,4]
["S1475","Pimasertib (AS-703026)","g9","L7100-02","in 10mM DMSO","MEK","MAPK","Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.",{"v":431.2,"d":"431.20"},"1236699-92-5",{"v":86,"d":"86.00"},199.44,"<1","N/A","http://selleckchem.com/products/AS703026.html","C15H15FIN3O3","free base","MSC1936369B, SAR 245509","OCC(O)CNC(=O)C1=CC=NC=C1NC2=C(F)C=C(I)C=C2",1.171,2,4,6]
["S1476","SB525334","h9","L7100-02","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.",343.42,"356559-20-1",{"v":68,"d":"68.00"},198.01,"<1","N/A","http://selleckchem.com/products/SB-525334.html","C21H21N5","free base","N/A","CC1=NC(=CC=C1)C2=C([NH]C(=N2)C(C)(C)C)C3=CC=C4N=CC=NC4=C3",4.305,4,1,3]
["S1485","HMN-214","a10","L7100-02","in 10mM DMSO","PLK","Cell Cycle","HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.",424.47,"173529-46-9",{"v":12,"d":"12.00"},28.27,"<1","N/A","http://selleckchem.com/products/HMN-214.html","C22H20N2O5S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)N(C(C)=O)C2=C(C=CC=C2)\\C=C\\C3=CC=[N+]([O-])C=C3",2.282,4,0,6]
["S1486","AEE788 (NVP-AEE788)","b10","L7100-02","in 10mM DMSO","EGFR,HER2,VEGFR","Protein Tyrosine Kinase","AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.",440.58,"497839-62-0",{"v":88,"d":"88.00"},199.74,"<1","N/A","http://selleckchem.com/products/AEE788.html","C27H32N6","free base","N/A","CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC(C)C5=CC=CC=C5)N=CN=C4[NH]3",5.042,2,2,7]
["S1487","PHA-793887","c10","L7100-02","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1.",361.48,"718630-59-2",{"v":72,"d":"72.00"},199.18,"<1","N/A","http://selleckchem.com/products/PHA-793887.html","C19H31N5O2","free base","N/A","CC(C)CC(=O)NC1=N[NH]C2=C1CN(C(=O)C3CCN(C)CC3)C2(C)C",1.895,3,2,4]
["S1490","Ponatinib (AP24534)","d10","L7100-02","in 10mM DMSO","Autophagy,Bcr-Abl,FGFR,PDGFR,Src,VEGFR","Angiogenesis","Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.",532.56,"943319-70-8",{"v":30,"d":"30.00"},56.33,"<1","N/A","http://selleckchem.com/products/AP24534.html","C29H27F3N6O","free base","AP24534","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F",4.884,3,1,7]
["S1491","Fludarabine (NSC 118218)","e10","L7100-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite,STAT","JAK/STAT","Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.",285.23,"21679-14-1",{"v":57,"d":"57.00"},199.84,"<1","N/A","http://selleckchem.com/products/Fludarabine(Fludara).html","C10H12FN5O4","Free Base","FaraA, Fludarabinum, NSC 118218","NC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)F",-1.312,4,4,2]
["S1497","Pralatrexate (NSC 754230)","f10","L7100-02","in 10mM DMSO","Apoptosis related,DHFR","Metabolism","Pralatrexate (NSC 754230) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.",477.47,"146464-95-1",{"v":28,"d":"28.00"},58.64,"<1","N/A","http://selleckchem.com/products/Pralatrexate(Folotyn).html","C23H23N7O5","free base","NSC 754230","NC1=NC(=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1)N",{"v":1.94,"d":"1.940"},7,3,10]
["S1501","Mycophenolate mofetil (RS-61443)","g10","L7100-02","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Mycophenolate Mofetil (RS 61443, Mycophenolic acid morpholinoethyl ester, CellCept, TM-MMF) is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.",433.49,"128794-94-5",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/Mycophenolate-mofetil-(CellCept).html","C23H31NO7","free base","Mycophenolic acid morpholinoethyl ester, CellCept, RS 61443, TM-MMF","COC1=C(C)C2=C(C(=O)OC2)C(=C1C\\C=C(C)\\CCC(=O)OCCN3CCOCC3)O",3.209,6,1,10]
["S1505","Aztreonam","h10","L7100-02","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.",435.43,"78110-38-0",{"v":87,"d":"87.00"},{"v":199.8,"d":"199.80"},{"v":11,"d":"11.00"},25.26,"http://selleckchem.com/products/Aztreonam(Azactam).html","C13H17N5O8S2","free base","SQ 26776","CC1C(NC(=O)\\C(=N/OC(C)(C)C(O)=O)C2=CSC(=N2)N)C(=O)N1[S](O)(=O)=O",-1.035,6,2,7]
["S1515","Pracinostat (SB939)","a11","L7100-02","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.",358.48,"929016-96-6",{"v":72,"d":"72.00"},200.85,"<1","N/A","http://selleckchem.com/products/SB939.html","C20H30N4O2","free base","N/A","CCCCC1=NC2=CC(=CC=C2[N]1CCN(CC)CC)\\C=C\\C(=O)NO",{"v":3.71,"d":"3.710"},2,1,10]
["S1524","AT7519","b11","L7100-02","in 10mM DMSO","Apoptosis related,CDK,GSK-3","Cell Cycle","AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also decrease GSK3β phosphorylation. AT7519 induces apoptosis. Phase 2.",382.24,"844442-38-2",{"v":10,"d":"10.00"},26.16,"<1","N/A","http://selleckchem.com/products/AT7519.html","C16H17Cl2N5O2","Free Base","N/A","ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",1.599,3,4,4]
["S1525","Adavosertib (MK-1775)","c11","L7100-02","in 10mM DMSO","Wee1","Cell Cycle","Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.",{"v":500.6,"d":"500.60"},"955365-80-7",{"v":80,"d":"80.00"},159.81,"N/A","N/A","http://selleckchem.com/products/MK-1775.html","C27H32N8O2","free base","AZD1775","CN1CCN(CC1)C2=CC=C(NC3=NC4=C(C=N3)C(=O)N(CC=C)N4C5=NC(=CC=C5)C(C)(C)O)C=C2",4.158,4,1,7]
["S1526","Quizartinib (AC220)","d11","L7100-02","in 10mM DMSO","Apoptosis related,FLT3,Target Protein Ligand","Angiogenesis","Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.",560.67,"950769-58-1",{"v":33,"d":"33.00"},58.86,"<1","N/A","http://selleckchem.com/products/AC-220.html","C29H32N6O4S","free base","N/A","CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=C[N]4C(=N3)SC5=CC(=CC=C45)OCCN6CCOCC6",5.064,6,2,8]
["S1529","Hesperadin","e11","L7100-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.",516.65,"422513-13-1",{"v":103,"d":"103.00"},199.36,"<1","N/A","http://selleckchem.com/products/Hesperadin.html","C29H32N4O3S","free base","N/A","CC[S](=O)(=O)NC1=CC=C2NC(=O)C(=C(NC3=CC=C(CN4CCCCC4)C=C3)/C5=CC=CC=C5)/C2=C1",4.071,3,3,8]
["S1530","BIX 02188","f11","L7100-02","in 10mM DMSO","MEK","MAPK","BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.",412.48,"1094614-84-2",{"v":43,"d":"43.00"},104.25,"<1","N/A","http://selleckchem.com/products/BIX-02188.html","C25H24N4O2","free base","N/A","CNC(=O)C1=CC=C\\2C(=C1)NC(=O)C2=C(\\NC3=CC(=CC=C3)CN(C)C)C4=CC=CC=C4",3.102,2,3,6]
["S1532","AZD7762","g11","L7100-02","in 10mM DMSO","Chk","Cell Cycle","AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.",362.42,"860352-01-8",{"v":50,"d":"50.00"},137.96,"<1","N/A","http://selleckchem.com/products/AZD7762.html","C17H19FN4O2S","free base","N/A","NC(=O)NC1=C(SC(=C1)C2=CC(=CC=C2)F)C(=O)NC3CCCNC3",2.009,2,4,4]
["S1536","CP-673451","h11","L7100-02","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.",{"v":417.5,"d":"417.50"},"343787-29-1",{"v":28,"d":"28.00"},67.07,"<1","N/A","http://selleckchem.com/products/CP-673451.html","C24H27N5O2","free base","N/A","COCCOC1=CC=C2[N](C=NC2=C1)C3=NC4=C(C=CC=C4C=C3)N5CCC(N)CC5",3.011,4,1,6]
["S1555","AZD8055","a2","L7100-03","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.",465.54,"1009298-09-2",{"v":50,"d":"50.00"},{"v":107.4,"d":"107.40"},"<1","N/A","http://selleckchem.com/products/AZD8055.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=C(C=C2)C(=NC(=N3)N4CCOCC4C)N5CCOCC5C",3.274,6,1,5]
["S1558","AT7867","b2","L7100-03","in 10mM DMSO","Akt,S6 Kinase","PI3K/Akt/mTOR","AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.",337.85,"857531-00-1",{"v":68,"d":"68.00"},201.27,"<1","N/A","http://selleckchem.com/products/AT7867.html","C20H20ClN3","free base","N/A","ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=C[NH]N=C4",{"v":3.85,"d":"3.850"},1,2,3]
["S1567","Pomalidomide (CC-4047)","c2","L7100-03","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.",273.24,"19171-19-8",{"v":54,"d":"54.00"},197.63,"<1","N/A","http://selleckchem.com/products/Pomalidomide(CC-4047).html","C13H11N3O4","free base","CC-4047","NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",{"v":-0.65,"d":"-0.650"},4,2,1]
["S1568","PD318088","d2","L7100-03","in 10mM DMSO","MEK","MAPK","PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.",561.09,"391210-00-7",{"v":112,"d":"112.00"},199.61,"<1","N/A","http://selleckchem.com/products/PD318088.html","C16H13BrF3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C(=C1)Br)F",3.327,2,4,7]
["S1576","Sulfasalazine (NSC 667219)","e2","L7100-03","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1","N/A","http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1590","TWS119","f2","L7100-03","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.",318.33,"601514-19-6",{"v":64,"d":"64.00"},201.05,"<1","N/A","http://selleckchem.com/products/TWS119.html","C18H14N4O2","free base","N/A","NC1=CC(=CC=C1)C2=CC3=C([NH]2)N=CN=C3OC4=CC=CC(=C4)O",3.464,3,3,3]
["S1591","Bestatin (NK421)","g2","L7100-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bestatin (Ubenimex,NK421) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.",308.37,"58970-76-6",{"v":4,"d":"4.00"},12.97,"<1","N/A","http://www.selleck.cn/products/Ubenimex(Bestatin).html","C16H24N2O4","Free Base","Ubenimex,NK421","CC(C)CC(NC(=O)C(O)C(N)CC1=CC=CC=C1)C(O)=O",{"v":-1.34,"d":"-1.340"},2,3,8]
["S1605","Cefdinir","h2","L7100-03","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.",395.41,"91832-40-5",{"v":79,"d":"79.00"},199.79,"<1","N/A","http://selleckchem.com/products/Cefdinir(Omnicef).html","C14H13N5O5S2","free base","FK 482, PD 134393, CI-983","NC1=NC(=CS1)C(=N/O)/C(=O)NC2C3SCC(=C(N3C2=O)C(O)=O)C=C",-0.172,5,2,5]
["S1606","Clotrimazole","a3","L7100-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Fungal","Microbiology","Clotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.",344.84,"23593-75-1",{"v":11,"d":"11.00"},{"v":31.9,"d":"31.90"},"<1","N/A","http://selleckchem.com/products/Clotrimazole(Canesten).html","C22H17ClN2","free base","BAY b 5097, FB 5097","ClC1=C(C=CC=C1)C([N]2C=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.222,1,0,4]
["S1614","Riluzole (PK 26124)","b3","L7100-03","in 10mM DMSO","GluR,Sodium Channel","Transmembrane Transporters","Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.",{"v":234.2,"d":"234.20"},"1744-22-5",{"v":46,"d":"46.00"},196.41,"<1","N/A","http://selleckchem.com/products/Riluzole(Rilutek).html","C8H5F3N2OS","free base","RP-54274, PK 26124","NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2",3.828,2,1,2]
["S1625","Ethinyl Estradiol","c3","L7100-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.",{"v":296.4,"d":"296.40"},"57-63-6",{"v":59,"d":"59.00"},199.06,"<1","N/A","http://selleckchem.com/products/Ethinyl-Estradiol.html","C20H24O2","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2(O)C#C",4.886,0,1,0]
["S1628","Triamcinolone Acetonide","d3","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Metabolism","Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.",{"v":434.5,"d":"434.50"},"76-25-5",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/Triamcinolone-Acetonide.html","C24H31FO6","free base","N/A","CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CO",1.157,4,2,2]
["S1645","Ketoprofen","e3","L7100-03","in 10mM DMSO","COX","Neuronal Signaling","Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.",254.28,"22071-15-4",{"v":51,"d":"51.00"},200.57,"<1","N/A","http://selleckchem.com/products/Ketoprofen(Actron).html","C16H14O3","free base","RP-19583","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S1649","Zolmitriptan","f3","L7100-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Zolmitriptan(BW-311C90) is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.",287.36,"139264-17-8",{"v":58,"d":"58.00"},201.84,"<1","N/A","http://selleckchem.com/products/Zolmitriptan(Zomig).html","C16H21N3O2","free base","BW-311C90","CN(C)CCC1=C[NH]C2=C1C=C(CC3COC(=O)N3)C=C2",2.457,2,2,5]
["S1652","Monobenzone","g3","L7100-03","in 10mM DMSO","Tyrosinase","Proteases","Monobenzone(Benoquin) is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.",200.23,"103-16-2",{"v":40,"d":"40.00"},199.77,"<1","N/A","http://selleckchem.com/products/Monobenzone(Benoquin).html","C13H12O2","free base","Benoquin","OC1=CC=C(OCC2=CC=CC=C2)C=C1",3.155,1,1,3]
["S1653","Tretinoin (NSC 122758)","h3","L7100-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.",{"v":300.4,"d":"300.40"},"302-79-4",{"v":60,"d":"60.00"},199.73,"<1","N/A","http://selleckchem.com/products/Tretinoin(Aberela).html","C20H28O2","free base","Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1654","Phenylbutazone","a4","L7100-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.",308.37,"50-33-9",{"v":62,"d":"62.00"},201.06,"<1","N/A","http://selleckchem.com/products/Phenylbutazone(Butazolidin).html","C19H20N2O2","free base","Butazolidine","CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3",3.954,2,0,5]
["S1658","Dofetilide","b4","L7100-03","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.",441.56,"115256-11-6",{"v":88,"d":"88.00"},199.29,"<1","N/A","http://selleckchem.com/products/Dofetilide(Tikosyn).html","C19H27N3O5S2","free base","UK-68798","CN(CCOC1=CC=C(N[S](C)(=O)=O)C=C1)CCC2=CC=C(N[S](C)(=O)=O)C=C2",1.679,5,2,11]
["S1680","Disulfiram (NSC 190940)","c4","L7100-03","in 10mM DMSO","Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis","Metabolism","Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).",296.54,"97-77-8",{"v":59,"d":"59.00"},198.96,"<1","N/A","http://selleckchem.com/products/Disulfiram(Antabuse).html","C10H20N2S4","free base","NSC 190940, Tetraethylthiuram disulfide, TETD","CCN(CC)C(=S)SSC(=S)N(CC)CC",{"v":5.6,"d":"5.600"},0,0,9]
["S1688","Betamethasone Dipropionate","d4","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.",504.59,"5593-20-4",{"v":100,"d":"100.00"},198.18,"<1","N/A","http://selleckchem.com/products/Betamethasone-Dipropionate(Diprolene).html","C28H37FO7","Free Base","SCH 11460","CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C",{"v":3.8,"d":"3.800"},6,1,8]
["S1690","Betamethasone Valerate","e4","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.",476.58,"2152-44-5",{"v":95,"d":"95.00"},199.34,"<1","N/A","http://selleckchem.com/products/Betamethasone-valerate(Betnovate).html","C27H37FO6","free base","N/A","CCCCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CO",3.666,4,2,7]
["S1692","Busulfan (NSC-750)","f4","L7100-03","in 10mM DMSO","Apoptosis related,DNA alkylator","DNA Damage/DNA Repair","Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.",{"v":246.3,"d":"246.30"},"55-98-1",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/Busulfan(Busulfex).html","C6H14O6S2","free base","NSC-750","C[S](=O)(=O)OCCCCO[S](C)(=O)=O",-0.289,2,0,7]
["S1701","Desonide","g4","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Desonide is a low potency topical corticosteroid.",416.51,"638-94-8",{"v":83,"d":"83.00"},199.27,"<1","N/A","http://selleckchem.com/products/Desonide.html","C24H32O6","free base","N/A","CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(O1)C(=O)CO",1.028,4,2,2]
["S1712","Deferasirox (ICL-670)","h4","L7100-03","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17)","Proteases","Deferasirox (ICL-670, CGP-72670) is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.",373.36,"201530-41-8",{"v":74,"d":"74.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Deferasirox(Exjade).html","C21H15N3O4","free base","CGP-72670, ICL-670","OC(=O)C1=CC=C(C=C1)[N]2N=C(N=C2C3=CC=CC=C3O)C4=CC=CC=C4O",4.063,3,2,4]
["S1714","Gemcitabine (LY-188011)","a5","L7100-03","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.",{"v":263.2,"d":"263.20"},"95058-81-4",{"v":52,"d":"52.00"},197.57,{"v":52,"d":"52.00"},197.57,"http://selleckchem.com/products/Gemcitabine(Gemzar).html","C9H11F2N3O4","Free Base","LY-188011, NSC 613327","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.394,3,3,2]
["S1718","Adefovir Dipivoxil (GS 0840)","b5","L7100-03","in 10mM DMSO","Reverse Transcriptase","Microbiology","Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).",501.47,"142340-99-6",{"v":100,"d":"100.00"},199.41,"<1","N/A","http://selleckchem.com/products/Adefovir-Dipivoxil(Preveon).html","C20H32N5O8P","free base","GS 0840","CC(C)(C)C(=O)OCO[P](=O)(COCC[N]1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C",1.666,10,1,15]
["S1721","Azathioprine","c5","L7100-03","in 10mM DMSO","Rho","Cell Cycle","Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.",277.26,"446-86-6",{"v":54,"d":"54.00"},194.76,"<1","N/A","http://selleckchem.com/products/Azathioprine(Azasan).html","C9H7N7O2S","free base","BW 57-322","C[N]1C=NC(=C1SC2=C3[NH]C=NC3=NC=N2)[N+]([O-])=O",1.071,4,1,3]
["S1727","Levonorgestrel","d5","L7100-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.",312.45,"797-63-7",{"v":45,"d":"45.00"},144.02,"<1","N/A","http://selleckchem.com/products/Levonorgestrel(Levonelle).html","C21H28O2","free base","D-Norgestrel","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S1734","Meloxicam","e5","L7100-03","in 10mM DMSO","COX","Neuronal Signaling","Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.",{"v":351.4,"d":"351.40"},"71125-38-7",{"v":30,"d":"30.00"},85.37,"<1","N/A","http://selleckchem.com/products/Meloxicam(Mobic).html","C14H13N3O4S2","free base","N/A","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=C(C)S3",0.255,4,2,2]
["S1735","Mesna","f5","L7100-03","in 10mM DMSO","Others","Others","Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.",164.18,"19767-45-4",{"v":33,"d":"33.00"},{"v":201,"d":"201.00"},{"v":7,"d":"7.00"},42.64,"http://selleckchem.com/products/Mesna(Uromitexan).html","C2H5NaO3S2","Sodium Salt","N/A","[Na+].[O-][S](=O)(=O)CCS",-2.227,0,0,2]
["S1736","Methocarbamol","g5","L7100-03","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.",241.24,"532-03-6",{"v":48,"d":"48.00"},198.97,{"v":2,"d":"2.00"},8.29,"http://selleckchem.com/products/Methocarbamol(Robaxin).html","C11H15NO5","free base","AHR 85","COC1=C(OCC(O)COC(N)=O)C=CC=C1",0.916,4,2,7]
["S1759","Pitavastatin (NK-104) calcium","h5","L7100-03","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1764","Rifampin (NSC-113926)","a6","L7100-03","in 10mM DMSO","Antibiotics for Plant Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Rifampin (NSC-113926, Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.",822.94,"13292-46-1",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Rifampin(Rifadin).html","C43H58N4O12","free base","Rimactane, Rifampicin,NSC-113926","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(C)CC5",3.262,8,6,5]
["S1768","Cefditoren Pivoxil","b6","L7100-03","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria.",620.72,"117467-28-4",{"v":100,"d":"100.00"},{"v":161.1,"d":"161.10"},"<1","N/A","http://selleckchem.com/products/Cefditoren-pivoxil.html","C25H28N6O7S3","free base","ME-1207","CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)\\C=C/C3=C(C)N=CS3)C4=CSC(=N4)N",1.926,10,2,12]
["S1774","Thioguanine (NSC 752)","c6","L7100-03","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1776","Toremifene Citrate (NK 622)","d6","L7100-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Toremifene Citrate (NK 622, NSC 613680) is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.",598.08,"89778-27-8",{"v":100,"d":"100.00"},{"v":167.2,"d":"167.20"},"<1","N/A","http://selleckchem.com/products/Toremifene-Citrate(Fareston).html","C32H36ClNO8","Citrate","NSC 613680,NK 622 Citrate","CN(C)CCOC1=CC=C(C=C1)\\C(=C(CCCl)/C2=CC=CC=C2)C3=CC=CC=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.945,4,0,14]
["S1778","Trifluridine (NSC 75520)","e6","L7100-03","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.",{"v":296.2,"d":"296.20"},"70-00-8",{"v":59,"d":"59.00"},199.19,{"v":59,"d":"59.00"},199.19,"http://selleckchem.com/products/Trifluridine(Viroptic).html","C10H11F3N2O5","free base","NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT","OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F",-0.782,3,3,3]
["S1782","Azacitidine (5-Azacytidine)","f6","L7100-03","in 10mM DMSO","Autophagy,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.",{"v":244.2,"d":"244.20"},"320-67-2",{"v":48,"d":"48.00"},196.56,"<1","N/A","http://selleckchem.com/products/Azacitidine(Vidaza).html","C8H12N4O5","free base","5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine","NC1=NC(=O)N(C=N1)C2OC(CO)C(O)C2O",-2.505,4,4,2]
["S1787","Teniposide","g6","L7100-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Teniposide (NSC 122819, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).",656.65,"29767-20-2",{"v":40,"d":"40.00"},60.92,"<1","N/A","http://selleckchem.com/products/Teniposide(Vumon).html","C32H32O13S","free base","NSC 122819, VM-26","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(OC5C(O)C4O)C6=CC=CS6)C7=CC8=C(OCO8)C=C27",2.516,10,3,6]
["S1792","Simvastatin (MK 733)","h6","L7100-03","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1806","Acipimox","a7","L7100-03","in 10mM DMSO","Others","Others","Acipimox (Olbemox,K-9321) is a niacin derivative used as a hypolipidemic agent.",154.12,"51037-30-0",{"v":31,"d":"31.00"},201.14,"<1","N/A","http://selleckchem.com/products/Acipimox.html","C6H6N2O3","free base","Olbemox,K-9321","CC1=CN=C(C=[N+]1[O-])C(O)=O",-0.975,2,0,1]
["S1820","Clofibrate","b7","L7100-03","in 10mM DMSO","Others","Others","Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.",{"v":242.7,"d":"242.70"},"637-07-0",{"v":7,"d":"7.00"},28.84,"<1","N/A","http://www.selleck.cn/products/Clofibrate(Atromid-S).html","C12H15ClO3","Free Base","N/A","CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1",3.329,3,0,5]
["S1828","Proparacaine HCl","c7","L7100-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.",330.85,"5875-06-9",{"v":12,"d":"12.00"},36.27,{"v":66,"d":"66.00"},199.49,"http://selleckchem.com/products/proparacaine-hcl.html","C16H26N2O3.HCl","Hydrochloride","Proxymetacaine Hydrochloride","Cl.CCCOC1=C(N)C=C(C=C1)C(=O)OCCN(CC)CC",3.013,3,1,10]
["S1839","Chloroxine","d7","L7100-03","in 10mM DMSO","Bacterial","Microbiology","Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.",214.05,"773-76-2",{"v":43,"d":"43.00"},200.89,"<1","N/A","http://selleckchem.com/products/Chloroxine.html","C9H5Cl2NO","free base","N/A","OC1=C(Cl)C=C(Cl)C2=C1N=CC=C2",3.103,1,1,0]
["S1845","Cimetidine","e7","L7100-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.",252.34,"51481-61-9",{"v":51,"d":"51.00"},202.11,"<1","N/A","http://selleckchem.com/products/Cimetidine(Tagamet).html","C10H16N6S","free base","SKF-92334","CNC(NCCSCC1=C(C)[NH]C=N1)=NC#N",0.007,2,3,7]
["S1883","Idoxuridine","f7","L7100-03","in 10mM DMSO","Antiviral","Microbiology","Idoxuridine (NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.",{"v":354.1,"d":"354.10"},"54-42-2",{"v":35,"d":"35.00"},98.84,"<1","N/A","http://selleckchem.com/products/idoxuridine.html","C9H11IN2O5","free base","NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd","OCC1OC(CC1O)N2C=C(I)C(=O)NC2=O",-1.402,3,3,2]
["S1884","Sparfloxacin","g7","L7100-03","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sparfloxacin (AT-4140, CI-978, PD 131501,Zagam) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.",{"v":392.4,"d":"392.40"},"110871-86-8",{"v":9,"d":"9.00"},22.94,"<1","N/A","http://selleckchem.com/products/sparfloxacin.html","C19H22F2N4O3","free base","AT-4140, CI-978, PD 131501,Zagam","CC1CN(CC(C)N1)C2=C(F)C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(O)=O",-1.056,2,2,3]
["S1888","Deflazacort","h7","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.",441.52,"14484-47-0",{"v":88,"d":"88.00"},199.31,"<1","N/A","http://selleckchem.com/products/Deflazacor.html","C25H31NO6","free base","MDL 458","CC(=O)OCC(=O)C12N=C(C)OC1CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC23C",{"v":1.67,"d":"1.670"},6,1,4]
["S1890","Nizatidine","a8","L7100-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.",331.46,"76963-41-2",{"v":66,"d":"66.00"},199.12,{"v":28,"d":"28.00"},84.47,"http://selleckchem.com/products/Nizatidine(Axid).html","C12H21N5O2S2","free base","N/A","CNC(/NCCSCC1=CSC(=N1)CN(C)C)=C/[N+]([O-])=O",0.643,1,2,10]
["S1896","Hydroxyurea (NSC-32065)","b8","L7100-03","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,HIV","DNA Damage/DNA Repair","Hydroxyurea (NSC-32065, NCI-C04831, Hydroxycarbamide) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.",76.05,"127-07-1",{"v":15,"d":"15.00"},197.24,{"v":15,"d":"15.00"},197.24,"http://selleckchem.com/products/Hydroxyurea(Cytodrox).html","CH4N2O2","free base","NCI-C04831, Hydroxycarbamide,NSC-32065","NC(=O)NO",{"v":-1.03,"d":"-1.030"},1,2,0]
["S1909","Fluvastatin (XU-62-320) Sodium","c8","L7100-03","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Fluvastatin Sodium (Vastin,XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.",433.45,"93957-55-2",{"v":87,"d":"87.00"},200.72,{"v":1,"d":"1.00"},2.31,"http://selleckchem.com/products/Fluvastatin-Sodium(Lescol).html","C24H25FNNaO4","Sodium","Vastin,XU-62-320","[Na+].CC(C)[N]1C2=C(C=CC=C2)C(=C1\\C=C\\C(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3",{"v":2.77,"d":"2.770"},0,2,8]
["S1917","Crystal Violet","d8","L7100-03","in 10mM DMSO","Dyes","Others","Crystal violet(Gentian Violet) is a triarylmethane dye.",407.98,"548-62-9",{"v":82,"d":"82.00"},200.99,{"v":14,"d":"14.00"},34.32,"http://selleckchem.com/products/Crystal-violet.html","C25H30ClN3","quaternary-N chloride salt","Gentian Violet","[Cl-].CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)N(C)C)=C3C=CC(C=C3)=[N+](C)C",{"v":2.25,"d":"2.250"},0,0,4]
["S1933","Triamcinolone","e8","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.",394.43,"124-94-7",{"v":78,"d":"78.00"},197.75,"<1","N/A","http://selleckchem.com/products/Triamcinolone(Aristocort).html","C21H27FO6","free base","N/A","CC12CC(O)C3(F)C(CCC4=CC(=O)C=CC34C)C1CC(O)C2(O)C(=O)CO",0.422,2,3,2]
["S1969","Nefiracetam","f8","L7100-03","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.",{"v":246.3,"d":"246.30"},"77191-36-7",{"v":49,"d":"49.00"},198.94,{"v":5,"d":"5.00"},{"v":20.3,"d":"20.30"},"http://selleckchem.com/products/Nefiracetam(Translon).html","C14H18N2O2","free base","DZL 221","CC1=CC=CC(=C1NC(=O)CN2CCCC2=O)C",1.443,2,1,3]
["S1971","Nicorandil","g8","L7100-03","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).",211.17,"65141-46-0",{"v":42,"d":"42.00"},198.89,{"v":17,"d":"17.00"},{"v":80.5,"d":"80.50"},"http://selleckchem.com/products/Nicorandil(Ikorel).html","C8H9N3O4","free base","SG-75","[O-][N+](=O)OCCNC(=O)C1=CC=CN=C1",1.758,3,1,5]
["S1973","Cyclocytidine HCl","h8","L7100-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.",261.66,"10212-25-6",{"v":10,"d":"10.00"},38.22,{"v":44,"d":"44.00"},168.16,"http://selleckchem.com/products/cyclocytidine-hcl.html","C9H12ClN3O4","Hydrochloride","NSC 145668 HCl","Cl.OCC1OC2C(OC3=NC(=N)C=CN23)C1O",-1.395,3,2,1]
["S1978","Methscopolamine","a9","L7100-03","in 10mM DMSO","AChR","Neuronal Signaling","Methscopolamine is a muscarinic acetylcholine receptor blocker.",398.29,"155-41-9",{"v":79,"d":"79.00"},198.35,{"v":67,"d":"67.00"},168.22,"http://selleckchem.com/products/Methscopolamine-bromide(Pamine).html","C18H24BrNO4","quaternary-N bromide salt","N/A","[Br-].C[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",-2.949,3,1,5]
["S1992","Fluticasone propionate","b9","L7100-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.",500.57,"80474-14-2",{"v":100,"d":"100.00"},199.77,"<1","N/A","http://selleckchem.com/products/fluticasone-propionate-Flonase-Veramyst.html","C25H31F3O5S","free base","CCI-187881","CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)SCF",4.086,4,1,6]
["S2006","Pyrimethamine","c9","L7100-03","in 10mM DMSO","DHFR","Metabolism","Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.",248.71,"58-14-0",{"v":10,"d":"10.00"},40.21,"<1","N/A","http://selleckchem.com/products/Pyrimethamine.html","C12H13ClN4","free base","RP 4753","CCC1=NC(=NC(=C1C2=CC=C(Cl)C=C2)N)N",{"v":2.75,"d":"2.750"},2,2,2]
["S2013","PF-573228","d9","L7100-03","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis.",491.49,"869288-64-2",{"v":26,"d":"26.00"},{"v":52.9,"d":"52.90"},"<1","N/A","http://selleckchem.com/products/pf-573228.html","C22H20F3N5O3S","free base","N/A","C[S](=O)(=O)C1=CC(=CC=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(NC(=O)CC4)C=C3",3.967,5,3,7]
["S2014","BMS-265246","e9","L7100-03","in 10mM DMSO","CDK","Cell Cycle","BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.",345.34,"582315-72-8",{"v":20,"d":"20.00"},57.91,"<1","N/A","http://selleckchem.com/products/bms-265246.html","C18H17F2N3O2","free base","N/A","CCCCOC1=C2C=N[NH]C2=NC=C1C(=O)C3=C(F)C=C(C)C=C3F",4.135,4,1,6]
["S2018","ENMD-2076 L-(+)-Tartaric acid","f9","L7100-03","in 10mM DMSO","Aurora Kinase,FLT3,VEGFR","Angiogenesis","ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.",525.56,"1291074-87-7",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/enmd-2076-l-tartaric-acid.html","C25H31N7O6","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)\\C=C\\C4=CC=CC=C4.OC(C(O)C(O)=O)C(O)=O",-0.683,5,4,8]
["S2026","Ginkgolide A","g9","L7100-03","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.",{"v":408.4,"d":"408.40"},"15291-75-5",{"v":81,"d":"81.00"},198.33,"<1","N/A","http://selleckchem.com/products/ginkgolide-a.html","C20H24O9","free base","BN52020","CC1C(=O)OC2CC34C5CC(C(C)(C)C)C36C(O)C(=O)OC6OC4(C(=O)O5)C12O",-0.022,7,1,1]
["S2028","Diclazuril","h9","L7100-03","in 10mM DMSO","Parasite","Microbiology","Diclazuril(R-64433) is an anti-coccidial drug.",407.64,"101831-37-2",{"v":16,"d":"16.00"},39.25,"<1","N/A","http://selleckchem.com/products/diclazuril.html","C17H9Cl3N4O2","free base","R-64433","ClC1=CC=C(C=C1)C(C#N)C2=C(Cl)C=C(C=C2Cl)N3N=CC(=O)NC3=O",4.191,3,1,3]
["S2037","Candesartan Cilexetil","a10","L7100-03","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.",610.66,"145040-37-5",{"v":122,"d":"122.00"},199.78,"<1","N/A","http://selleckchem.com/products/Candesartan-cilexetil-Atacand.html","C33H34N6O6","free base","TCV-116","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=N[NH]5)C(=CC=C2)C(=O)OC(C)OC(=O)OC6CCCCC6",6.913,10,1,13]
["S2042","Cyproterone Acetate","b10","L7100-03","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.",416.94,"427-51-0",{"v":83,"d":"83.00"},199.07,"<1","N/A","http://selleckchem.com/products/cyproterone-acetate.html","C24H29ClO4","free base","N/A","CC(=O)OC1(CCC2C3C=C(Cl)C4=CC(=O)C5CC5C4(C)C3CCC12C)C(C)=O",3.314,4,0,3]
["S2045","Doxifluridine","c10","L7100-03","in 10mM DMSO","Phosphorylase","Metabolism","Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).",246.19,"3094-09-5",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/doxifluridine.html","C9H11FN2O5","free base","5'-DFUR, AMC 0101","CC1OC(C(O)C1O)N2C=C(F)C(=O)NC2=O",-1.653,3,3,1]
["S2055","Gimeracil","d10","L7100-03","in 10mM DMSO","Dehydrogenase","Metabolism","Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.",145.54,"103766-25-2",{"v":29,"d":"29.00"},199.26,"<1","N/A","http://selleckchem.com/products/gimeracil.html","C5H4ClNO2","free base","N/A","OC1=CC(=O)NC=C1Cl",-0.493,1,2,0]
["S2057","Cyclophosphamide (NSC-26271) Monohydrate","e10","L7100-03","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.",{"v":279.1,"d":"279.10"},"6055-19-2",{"v":55,"d":"55.00"},197.06,{"v":7,"d":"7.00"},25.08,"http://selleckchem.com/products/cyclophosphamide-monohydrate.html","C7H15Cl2N2O2P.H2O","Monohydrate","Cytoxan Monohydrate","O.ClCCN(CCCl)[P]1(=O)NCCCO1",-0.063,2,1,5]
["S2061","Lovastatin (MK-803)","f10","L7100-03","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Lovastatin (MK-803, Mevinolin,Mevacor) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.",404.54,"75330-75-5",{"v":8,"d":"8.00"},19.78,"<1","N/A","http://selleckchem.com/products/lovastatin-mevacor.html","C24H36O5","free base","Mevinolin,Mevacor","CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.218,4,1,7]
["S2065","Lafutidine","g10","L7100-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lafutidine (FRG-8813), a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.",431.55,"118288-08-7",{"v":86,"d":"86.00"},199.28,"<1","N/A","http://selleckchem.com/products/lafutidine.html","C22H29N3O4S","free base","FRG-8813","O=C(C[S](=O)CC1=CC=CO1)NC\\C=C/COC2=CC(=CC=N2)CN3CCCCC3",1.987,5,1,11]
["S2078","Famotidine","h10","L7100-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.",337.45,"76824-35-6",{"v":67,"d":"67.00"},198.55,"<1","N/A","http://selleckchem.com/products/famotidine-pepcid.html","C8H15N7O2S3","free base","MK208","NC(=N)NC1=NC(=CS1)CSCCC(=N)N[S](N)(=O)=O",-1.328,3,4,9]
["S2098","Bexarotene (LGD1069)","a11","L7100-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.",{"v":348,"d":"348.00"},"153559-49-0",{"v":8,"d":"8.00"},22.99,"<1","N/A","http://selleckchem.com/products/bexarotene.html","C24H28O2","free base","Targretin","CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(O)=O)C(C)(C)CCC2(C)C",6.405,1,0,3]
["S2103","Naltrexone HCl","b11","L7100-03","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.",377.86,"16676-29-2",{"v":14,"d":"14.00"},37.05,{"v":14,"d":"14.00"},37.05,"http://selleckchem.com/products/naltrexone-hcl.html","C20H23NO4.HCl","Hydrochloride","PTI-901","Cl.OC1=CC=C2CC3N(CCC45C(OC1=C24)C(=O)CCC35O)CC6CC6",2.039,2,1,2]
["S2109","Imidapril HCl","c11","L7100-03","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.",441.91,"89396-94-1",{"v":88,"d":"88.00"},199.14,{"v":54,"d":"54.00"},{"v":122.2,"d":"122.20"},"http://selleckchem.com/products/imidapril-tanatril.html","C20H27N3O6.HCl","Hydrochloride","TA-6366","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C)C2=O)C(O)=O",-1.197,5,1,10]
["S2118","Ibutilide Fumarate","d11","L7100-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ibutilide Fumarate (U-70226E,Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.",885.23,"122647-32-9",{"v":89,"d":"89.00"},100.54,{"v":89,"d":"89.00"},100.54,"http://selleckchem.com/products/ibutilide-fumarate.html","(C20H36N2O3S)2.C4H4O4","Fumarate","U-70226E,Corvert Fumarate","CCCCCCCN(CC)CCCC(O)C1=CC=C(N[S](C)(=O)=O)C=C1.CCCCCCCN(CC)CCCC(O)C2=CC=C(N[S](C)(=O)=O)C=C2.OC(=O)\\C=C\\C(O)=O",1.954,6,4,30]
["S2134","AZD8330","e11","L7100-03","in 10mM DMSO","MEK","MAPK","AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.",461.23,"869357-68-6",{"v":92,"d":"92.00"},199.47,"<1","N/A","http://selleckchem.com/products/AZD8330(ARRY-424704).html","C16H17FIN3O4","free base","ARRY704","CN1C(=O)C(=CC(=C1NC2=C(F)C=C(I)C=C2)C(=O)NOCCO)C",1.653,3,3,6]
["S2149","GSK1292263","f11","L7100-03","in 10mM DMSO","GPR","Endocrinology & Hormones","GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. Phase 2.",456.56,"1032823-75-8",{"v":34,"d":"34.00"},74.47,"<1","N/A","http://selleckchem.com/products/GSK1292263.html","C23H28N4O4S","free base","N/A","CC(C)C1=NOC(=N1)N2CCC(CC2)COC3=CN=C(C=C3)C4=CC=C(C=C4)[S](C)(=O)=O",3.893,7,0,7]
["S2151","Sonidegib (NVP-LDE225)","g11","L7100-03","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.",{"v":485.5,"d":"485.50"},"956697-53-3",{"v":97,"d":"97.00"},199.79,"<1","N/A","http://selleckchem.com/products/LDE225(NVP-LDE225).html","C26H26F3N3O3","free base","Erismodegib","CC1CN(CC(C)O1)C2=CC=C(NC(=O)C3=C(C)C(=CC=C3)C4=CC=C(OC(F)(F)F)C=C4)C=N2",6.732,4,1,6]
["S2155","LY2608204","h11","L7100-03","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.",559.81,"1234703-40-2",{"v":112,"d":"112.00"},200.07,"<1","N/A","http://selleckchem.com/products/ly2608204.html","C28H37N3O3S3","free base","N/A","O=C(NC1=NC=C(SCCN2CCCC2)S1)C3(CC3C4CCCCC4)C5=CC=C(C=C5)[S](=O)(=O)C6CC6",5.393,4,1,10]
["S2158","KW-2449","a2","L7100-04","in 10mM DMSO","Aurora Kinase,Bcr-Abl,FLT3","Angiogenesis","KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.",{"v":332.4,"d":"332.40"},"1000669-72-6",{"v":67,"d":"67.00"},201.56,"<1","N/A","http://selleckchem.com/products/KW-2449.html","C20H20N4O","free base","N/A","O=C(N1CCNCC1)C2=CC=C(C=C2)/C=C/C3=N[NH]C4=C3C=CC=C4",2.723,2,2,3]
["S2160","Almorexant HCl","b2","L7100-04","in 10mM DMSO","OX Receptor","GPCR & G Protein","Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.",549.02,"913358-93-7",{"v":72,"d":"72.00"},131.14,"<1","N/A","http://selleckchem.com/products/almorexant-hcl.html","C29H32ClF3N2O3","Hydrochloride","ACT-078573 HCl","Cl.CNC(=O)C(N1CCC2=C(C=C(OC)C(=C2)OC)C1CCC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C4",6.438,3,1,9]
["S2162","AZD1480","c2","L7100-04","in 10mM DMSO","JAK","JAK/STAT","AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.",348.77,"935666-88-9",{"v":70,"d":"70.00"},200.71,"<1","N/A","http://www.selleck.cn/products/AZD1480.html","C14H14ClFN8","free base","N/A","CC(NC1=NC=C(Cl)C(=N1)NC2=N[NH]C(=C2)C)C3=NC=C(F)C=N3",2.645,5,3,5]
["S2170","Givinostat (ITF2357)","d2","L7100-04","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.",475.97,"732302-99-7",{"v":95,"d":"95.00"},199.59,"<1","N/A","http://selleckchem.com/products/ITF2357(Givinostat).html","C24H27N3O4.HCl.H2O","Chloride","N/A","O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC3=CC=C(C=C3)C(=O)NO)C=C2",4.046,3,2,9]
["S2178","AG-14361","e2","L7100-04","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.",320.39,"328543-09-5",{"v":12,"d":"12.00"},37.45,"<1","N/A","http://selleckchem.com/products/AG14361.html","C19H20N4O","free base","N/A","CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3[N]2CCNC4=O",2.576,2,1,3]
["S2179","Gandotinib (LY2784544)","f2","L7100-04","in 10mM DMSO","JAK","JAK/STAT","Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.",469.94,"1229236-86-5",{"v":94,"d":"94.00"},200.03,"<1","N/A","http://selleckchem.com/products/LY2784544.html","C23H25ClFN7O","free base","N/A","CC1=N[NH]C(=C1)NC2=N[N]3C(=C(C)N=C3C(=C2)CN4CCOCC4)CC5=CC=C(Cl)C=C5F",3.938,4,2,6]
["S2181","Ixazomib Citrate (MLN9708) Analogue","g2","L7100-04","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.",517.12,"1201902-80-8",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://selleckchem.com/products/MLN9708.html","C20H23BCl2N2O9","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)CC(CC(O)=O)(O2)C(O)=O",3.497,7,2,10]
["S2182","SB743921 HCl","h2","L7100-04","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.",553.52,"940929-33-9",{"v":111,"d":"111.00"},200.53,{"v":22,"d":"22.00"},39.75,"http://selleckchem.com/products/SB-743921.html","C31H33N2O3.HCl","Hydrochloride","N/A","Cl.CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=C(CC3=CC=CC=C3)C(=O)C4=C(O2)C=C(Cl)C=C4",6.536,3,1,9]
["S2185","Allitinib tosylate","a3","L7100-04","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Allitinib tosylate (AST-1306 TsOH, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.",621.08,"1050500-29-2",{"v":124,"d":"124.00"},199.65,"<1","N/A","https://www.selleckchem.com/products/allitinib-tosylate.html","C24H18ClFN4O2,C7H8O3S","Mesylate","AST-1306 TsOH, AST-6","CC1=CC=C(C=C1)[S](O)(=O)=O.FC2=CC(=CC=C2)COC3=CC=C(NC4=C5C=C(NC(=O)C=C)C=CC5=NC=N4)C=C3Cl",7.381,4,2,8]
["S2186","SB505124","b3","L7100-04","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.",{"v":335.4,"d":"335.40"},"694433-59-5",{"v":67,"d":"67.00"},199.76,"<1","N/A","http://selleckchem.com/products/sb-505124.html","C20H21N3O2","free base","N/A","CC1=CC=CC(=N1)C2=C(N=C([NH]2)C(C)(C)C)C3=CC4=C(OCO4)C=C3",4.609,4,1,3]
["S2192","Sapitinib (AZD8931)","c3","L7100-04","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.",473.93,"848942-61-0",{"v":40,"d":"40.00"},{"v":84.4,"d":"84.40"},"<1","N/A","http://selleckchem.com/products/AZD8931.html","C23H25ClFN5O3","free base","N/A","CNC(=O)CN1CCC(CC1)OC2=C(OC)C=C3N=CN=C(NC4=C(F)C(=CC=C4)Cl)C3=C2",3.485,5,2,7]
["S2193","GSK461364","d3","L7100-04","in 10mM DMSO","PLK","Cell Cycle","GSK461364 (GSK461364A) inhibits purified Plk1 with Ki of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3.",{"v":543.6,"d":"543.60"},"929095-18-1",{"v":10,"d":"10.00"},{"v":18.4,"d":"18.40"},"<1","N/A","http://selleckchem.com/products/GSK461364.html","C27H28F3N5O2S","free base","GSK461364A","CC(OC1=C(SC(=C1)[N]2C=NC3=C2C=C(CN4CCN(C)CC4)C=C3)C(N)=O)C5=CC=CC=C5C(F)(F)F",5.125,3,1,8]
["S2194","R406","e3","L7100-04","in 10mM DMSO","Apoptosis related,FLT3,Syk","Angiogenesis","R406 is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 induces apoptosis. Phase 1.",628.63,"841290-81-1",{"v":100,"d":"100.00"},159.08,"<1","N/A","http://selleckchem.com/products/R406.html","C22H23FN6O5.C6H6O3S","Besylate","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC(=C(F)C=N2)NC3=NC4=C(OC(C)(C)C(=O)N4)C=C3)OC.O[S](=O)(=O)C5=CC=CC=C5",5.044,8,3,8]
["S2195","Lexibulin (CYT997)","f3","L7100-04","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.",434.53,"917111-44-5",{"v":86,"d":"86.00"},197.91,"<1","N/A","http://selleckchem.com/products/CYT997.html","C24H30N6O2","free base","SRI-32007","CCCC(NC1=C(C)C=NC(=N1)C2=CC(=C(NC(=O)NCC)C=C2)OC)C3=CC=CN=C3",3.744,5,3,9]
["S2198","SGI-1776 free base","g3","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,FLT3,Haspin Kinase,Pim","JAK/STAT","SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.",405.42,"1025065-69-3",{"v":81,"d":"81.00"},199.79,"<1","N/A","http://selleckchem.com/products/SGI-1776.html","C20H22F3N5O","free base","N/A","CN1CCC(CC1)CNC2=N[N]3C(=NC=C3C4=CC=CC(=C4)OC(F)(F)F)C=C2",5.206,3,1,6]
["S2202","NVP-BHG712","h3","L7100-04","in 10mM DMSO","Bcr-Abl,Ephrin receptor,Raf,Src","Protein Tyrosine Kinase","NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.",503.48,"940310-85-0",{"v":101,"d":"101.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/NVP-BHG712.html","C26H20F3N7O","free base","N/A","C[N]1N=CC2=C1N=C(N=C2NC3=CC(=CC=C3C)C(=O)NC4=CC=CC(=C4)C(F)(F)F)C5=CC=CN=C5",4.871,5,2,6]
["S2205","OSI-420","a4","L7100-04","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","OSI-420 (DesMethyl Erlotinib, CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).",415.87,"183320-51-6",{"v":83,"d":"83.00"},199.58,"<1","N/A","http://selleckchem.com/products/OSI-420-Desmethyl-Erlotinib,CP-473420.html","C21H21N3O4.HCl","Hydrochloride","DesMethyl Erlotinib (CP-473420) HCl","Cl.COCCOC1=CC2=C(C=C1OCCO)C(=NC=N2)NC3=CC=CC(=C3)C#C",4.283,5,2,9]
["S2214","AZ 960","b4","L7100-04","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.",354.36,"905586-69-8",{"v":71,"d":"71.00"},200.36,"<1","N/A","http://selleckchem.com/products/AZ-960.html","C18H16F2N6","free base","N/A","CC(NC1=NC(=C(F)C=C1C#N)NC2=N[NH]C(=C2)C)C3=CC=C(F)C=C3",4.495,2,3,5]
["S2216","Mubritinib (TAK 165)","c4","L7100-04","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line.",468.47,"366017-09-6",{"v":13,"d":"13.00"},27.75,"<1","N/A","http://selleckchem.com/products/Mubritinib-TAK-165.html","C25H23F3N4O2","free base","N/A","FC(F)(F)C1=CC=C(\\C=C\\C2=NC(=CO2)COC3=CC=C(CCCC[N]4C=CN=N4)C=C3)C=C1",5.844,5,0,11]
["S2217","Irinotecan (CPT-11) HCl Trihydrate","d4","L7100-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.",677.18,"136572-09-3",{"v":100,"d":"100.00"},147.67,{"v":1,"d":"1.00"},1.48,"http://selleckchem.com/products/Irinotecan-Hcl-Trihydrate-Campto.html","C33H38N4O6.HCl.3H2O","HCl & trihydrat","CPT-11 HCl Trihydrate","O.O.O.Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=CC=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C15)C(O)(CC)C(=O)OC4",3.446,6,0,5]
["S2218","Torkinib (PP242)","e4","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,mTOR","PI3K/Akt/mTOR","Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242) induces mitophagy and apoptosis.",308.34,"1092351-67-1",{"v":61,"d":"61.00"},197.83,"<1","N/A","http://selleckchem.com/products/PP242.html","C16H16N6O","free base","N/A","CC(C)[N]1N=C(C2=CC3=C([NH]2)C=CC(=C3)O)C4=C(N)N=CN=C14",2.908,3,3,2]
["S2219","Momelotinib (CYT387)","f4","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,JAK","JAK/STAT","Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.",414.46,"1056634-68-4",{"v":74,"d":"74.00"},178.55,"<1","N/A","http://selleckchem.com/products/Cyt387.html","C23H22N6O2","free base","LM-1149 , CYT11387","O=C(NCC#N)C1=CC=C(C=C1)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.857,4,2,6]
["S2220","SB590885","g4","L7100-04","in 10mM DMSO","Raf","MAPK","SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.",453.54,"405554-55-4",{"v":5,"d":"5.00"},11.02,"<1","N/A","http://selleckchem.com/products/SB590885.html","C27H27N5O2","free base","N/A","CN(C)CCOC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=C\\4C(=C3)CCC4=N\\O)C5=CC=NC=C5",4.503,4,1,7]
["S2224","UK 383367","h4","L7100-04","in 10mM DMSO","Procollagen C Proteinase","Metabolism","UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.",324.38,"348622-88-8",{"v":65,"d":"65.00"},200.38,"<1","N/A","http://selleckchem.com/products/UK-383367.html","C15H24N4O4","free base","N/A","NC(=O)C1=NOC(=N1)C(CCCC2CCCCC2)CC(=O)NO",1.731,5,2,8]
["S2226","Idelalisib","a5","L7100-04","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.",415.42,"870281-82-6",{"v":83,"d":"83.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/CAL-101.html","C22H18FN7O","free base","CAL-101, GS-1101","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=NC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)F",3.624,5,2,5]
["S2228","Belnacasan (VX-765)","b5","L7100-04","in 10mM DMSO","Caspase","Apoptosis","Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.",{"v":509,"d":"509.00"},"273404-37-8",{"v":100,"d":"100.00"},196.46,"<1","N/A","http://selleckchem.com/products/VX-765.html","C24H33ClN4O6","free base","N/A","CCOC1OC(=O)CC1NC(=O)C2CCCN2C(=O)C(NC(=O)C3=CC(=C(N)C=C3)Cl)C(C)(C)C",1.698,6,3,8]
["S2231","Telatinib","c5","L7100-04","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. Phase 2.",409.83,"332012-40-5",{"v":82,"d":"82.00"},200.08,"<1","N/A","http://selleckchem.com/products/Telatinib-BAY-57-9352.html","C20H16ClN5O3","free base","BAY 57-9352","CNC(=O)C1=NC=CC(=C1)COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4",3.861,6,2,6]
["S2235","Volasertib (BI 6727)","d5","L7100-04","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.",618.81,"755038-65-4",{"v":20,"d":"20.00"},32.32,"<1","N/A","http://selleckchem.com/products/BI6727-Volasertib.html","C34H50N8O3","free base","N/A","CCC1N(C(C)C)C2=C(C=NC(=N2)NC3=CC=C(C=C3OC)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)N(C)C1=O",4.838,5,2,10]
["S2238","Palomid 529 (P529)","e5","L7100-04","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.",406.43,"914913-88-5",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/Palomid-529-P529.html","C24H22O6","free base","SG 00529","COC1=CC=C(COC2=C(OC)C=C3C(=C2)OC(=O)C4=C3C=CC(=C4)C(C)O)C=C1",4.257,5,1,6]
["S2243","Degrasyn (WP1130)","f5","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,DUB","Angiogenesis","Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.",384.27,"856243-80-6",{"v":77,"d":"77.00"},200.38,"<1","N/A","http://selleckchem.com/products/WP1130.html","C19H18BrN3O","free base","N/A","CCCC(NC(=O)/C(=C/C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",4.546,2,1,6]
["S2244","AR-42","g5","L7100-04","in 10mM DMSO","HDAC","Epigenetics","AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.",312.36,"935881-37-1",{"v":63,"d":"63.00"},201.69,"<1","N/A","http://selleckchem.com/products/AR-42-HDAC-42.html","C18H20N2O3","free base","HDAC-42","CC(C)C(C(=O)NC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",2.834,2,2,5]
["S2246","Abiraterone Acetate (CB7630)","h5","L7100-04","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Abiraterone Acetate (CB7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.",391.55,"154229-18-2",{"v":20,"d":"20.00"},51.08,"<1","N/A","http://www.selleck.cn/products/Abiraterone-Acetate-CB7630.html","C26H33NO2","Acetate","CB7630, CB-7630","CC(=O)OC1CCC2(C)C3CCC4(C)C(CC=C4C5=CC=CN=C5)C3CC=C2C1",4.602,3,0,3]
["S2247","Buparlisib (BKM120)","a6","L7100-04","in 10mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.",410.39,"944396-07-0",{"v":82,"d":"82.00"},199.81,"<1","N/A","http://selleckchem.com/products/BKM-120.html","C18H21F3N6O2","free base","NVP-BKM120","NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F",2.342,5,1,4]
["S2248","Silmitasertib (CX-4945)","b6","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase","Metabolism","Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.",349.77,"1009820-21-6",{"v":16,"d":"16.00"},45.74,"<1","N/A","http://selleckchem.com/products/cx-4945-silmitasertib.html","C19H12ClN3O2","free base","N/A","OC(=O)C1=CC2=C(C=C1)C3=CN=CC=C3C(=N2)NC4=CC(=CC=C4)Cl",4.157,3,1,3]
["S2252","(+)-Usniacin","c6","L7100-04","in 10mM DMSO","Others","Others","(+)-Usniacin (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.",344.32,"7562-61-0",{"v":4,"d":"4.00"},11.62,"<1","N/A","http://selleckchem.com/products/Usniacin-D-Usnic-acid.html","C18H16O7","free base","D-Usnic Acid","CC(=O)C1=C(O)C(=C(O)C2=C1OC3=CC(=O)C(=C(O)C23C)C(C)=O)C",1.087,4,3,2]
["S2265","Artesunate (WR-256283)","d6","L7100-04","in 10mM DMSO","ADC Cytotoxin,STAT","JAK/STAT","Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.",384.42,"88495-63-0",{"v":77,"d":"77.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/Artesunate.html","C19H28O8","free base","WR-256283","CC1CCC2C(C)C(OC3OC4(C)CCC1C23OO4)OC(=O)CCC(O)=O",1.845,7,0,5]
["S2269","Baicalin (NSC-661431)","e6","L7100-04","in 10mM DMSO","GABA Receptor,PREP","Neuronal Signaling","Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.",446.36,"21967-41-9",{"v":89,"d":"89.00"},199.39,"<1","N/A","http://selleckchem.com/products/Baicalin.html","C21H18O11","free base","N/A","OC1C(O)C(OC(C1O)C(O)=O)OC2=C(O)C(=C3C(=O)C=C(OC3=C2)C4=CC=CC=C4)O",0.608,5,5,4]
["S2280","Chlorogenic Acid","f6","L7100-04","in 10mM DMSO","Others","Others","Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.",354.31,"327-97-9",{"v":71,"d":"71.00"},200.39,{"v":18,"d":"18.00"},{"v":50.8,"d":"50.80"},"http://selleckchem.com/products/Chlorogenic-acid.html","C16H18O9","free base","NSC 407296, Heriguard","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S2286","Cyclosporin A (NSC 290193)","g6","L7100-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Complement System,Immunology & Inflammation related,phosphatase","Immunology & Inflammation","Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.",1202.61,"59865-13-3",{"v":100,"d":"100.00"},83.15,"<1","N/A","http://selleckchem.com/products/Cyclosporin-A(Cyclosporine-A).html","C62H111N11O12","free base","Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193","CCC1NC(=O)C(C(O)C(C)C\\C=C\\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C",4.333,11,5,15]
["S2290","Dihydroartemisinin (DHA)","h6","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,NF-κB","NF-κB","Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.",284.35,"71939-50-9",{"v":56,"d":"56.00"},196.94,"<1","N/A","http://selleckchem.com/products/Dihydroartemisinin(DHA).html","C15H24O5","free base","Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol","CC1CCC2C(C)C(O)OC3OC4(C)CCC1C23OO4",1.621,4,0,0]
["S2296","Enoxolone","a7","L7100-04","in 10mM DMSO","Dehydrogenase","Metabolism","Enoxolone (Glycyrrhetin) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.",470.68,"471-53-4",{"v":94,"d":"94.00"},199.71,"<1","N/A","http://selleckchem.com/products/Enoxolone(Glycyrrhetin).html","C30H46O4","free base","Glycyrrhetin","CC1(C)C(O)CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.656,2,1,1]
["S2311","Hyodeoxycholic acid (HDCA)","b7","L7100-04","in 10mM DMSO","GPCR19","GPCR & G Protein","Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.",392.57,"83-49-8",{"v":78,"d":"78.00"},198.69,"<1","N/A","http://selleckchem.com/products/Hyodeoxycholic-acid(HDCA).html","C24H40O4","free base","NSC 60672","CC(CCC(O)=O)C1CCC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C",4.014,1,2,4]
["S2334","Oleanolic Acid","c7","L7100-04","in 10mM DMSO","Antiviral","Microbiology","Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.",{"v":456.7,"d":"456.70"},"508-02-1",{"v":21,"d":"21.00"},45.98,"<1","N/A","http://selleckchem.com/products/Oleanolic-Acid(Caryophyllin).html","C30H48O3","free base","Caryophyllin","CC1(C)CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",6.282,1,1,1]
["S2335","Oridonin (NSC-250682)","d7","L7100-04","in 10mM DMSO","Akt,Bacterial","PI3K/Akt/mTOR","Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.",364.43,"28957-04-2",{"v":72,"d":"72.00"},197.57,"<1","N/A","http://selleckchem.com/products/Oridonin(Isodonol).html","C20H28O6","free base","Isodonol, Rubescenin","CC1(C)CCC(O)C23COC(O)(C(O)C12)C45C(O)C(CCC34)C(=C)C5=O",{"v":0.2,"d":"0.200"},2,3,0]
["S2338","Oxymatrine","e7","L7100-04","in 10mM DMSO","Immunology & Inflammation related","TGF-beta/Smad","Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.",264.36,"16837-52-8",{"v":53,"d":"53.00"},200.48,{"v":53,"d":"53.00"},200.48,"http://selleckchem.com/products/Oxymatrine(Matrine-N-oxide).html","C15H24N2O2","free base","Matrine N-oxide","[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23",{"v":0.61,"d":"0.610"},1,0,0]
["S2341","(-)-Parthenolide","f7","L7100-04","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2364","Tanshinone I","g7","L7100-04","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.",276.29,"568-73-0",{"v":23,"d":"23.00"},83.25,"<1","N/A","http://selleckchem.com/products/Tanshinone-I.html","C18H12O3","free base","N/A","CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C)C=CC=C34",4.084,3,0,0]
["S2377","Biochanin A","h7","L7100-04","in 10mM DMSO","FAAH","Metabolism","Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.",284.26,"491-80-5",{"v":57,"d":"57.00"},200.52,"<1","N/A","http://selleckchem.com/products/Biochanin-A(4-Methylgenistein).html","C16H12O5","free base","4-Methylgenistein","COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O",2.366,3,2,2]
["S2378","Butylscopolamine Bromide","a8","L7100-04","in 10mM DMSO","AChR","Neuronal Signaling","Butylscopolamine Bromide (Scopolamine Butylbromide,(-)-Scopolamine butylbromide, Hyoscine butylbromide), is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.",440.37,"149-64-4",{"v":88,"d":"88.00"},199.83,{"v":88,"d":"88.00"},199.83,"http://selleckchem.com/products/butylscopolamine-bromide.html","C21H30NO4.Br","Bromide","Scopolamine Butylbromide,(-)-Scopolamine butylbromide, Hyoscine butylbromide","[Br-].CCCC[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",{"v":-1.62,"d":"-1.620"},3,1,8]
["S2383","Gastrodin","b8","L7100-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.",286.28,"62499-27-8",{"v":50,"d":"50.00"},174.65,"<1","N/A","http://selleckchem.com/products/Gastrodin(Gastrodine).html","C13H18O7","free base","Gastrodine","OCC1OC(OC2=CC=C(CO)C=C2)C(O)C(O)C1O",-0.947,2,5,4]
["S2386","Indirubin (NSC 105327)","c8","L7100-04","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Indirubin (NSC 105327) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.",262.26,"479-41-4",{"v":53,"d":"53.00"},202.09,"<1","N/A","http://selleckchem.com/products/Indirubin.html","C16H10N2O2","free base","NSC 105327","O=C1NC2=CC=CC=C2\\C1=C3/NC4=C(C=CC=C4)C3=O",1.876,2,2,0]
["S2387","Lappaconite HBr","d8","L7100-04","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.",665.61,"97792-45-5",{"v":28,"d":"28.00"},42.07,"<1","N/A","http://selleckchem.com/products/Lappaconite-Hydrobromide.html","C32H44N2O8.HBr","Hydrobromide","N/A","Br.CCN1CC2(CCC(OC)C34C2CC(C13)C5(O)CC(OC)C6CC4C5(O)C6OC)OC(=O)C7=C(NC(C)=O)C=CC=C7",{"v":0.52,"d":"0.520"},6,1,8]
["S2388","L-carnitine","e8","L7100-04","in 10mM DMSO","Others","Others","L-carnitine (Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine) is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.",{"v":161.2,"d":"161.20"},"541-15-1",{"v":12,"d":"12.00"},74.44,{"v":32,"d":"32.00"},198.51,"http://selleckchem.com/products/L-carnitine(Levocarnitine).html","C7H15NO3","quaternary-N  salt","Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine","C[N+](C)(C)CC(O)CC([O-])=O",{"v":-3.29,"d":"-3.290"},0,1,4]
["S2390","Polydatin","f8","L7100-04","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.",390.38,"65914-17-2",{"v":78,"d":"78.00"},199.81,"<1","N/A","http://selleckchem.com/products/Polydatin(Piceid).html","C20H22O8","free base","Piceid","OCC1OC(OC2=CC(=CC(=C2)\\C=C\\C3=CC=C(O)C=C3)O)C(O)C(O)C1O",{"v":1.16,"d":"1.160"},2,6,5]
["S2396","Salidroside","g8","L7100-04","in 10mM DMSO","Mitophagy,mTOR,PREP","PI3K/Akt/mTOR","Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.",{"v":300.3,"d":"300.30"},"10338-51-9",{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Salidroside-Rhodioloside.html","C14H20O7","free base","Rhodioloside","OCC1OC(OCCC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.443,2,5,5]
["S2397","Palmatine chloride","h8","L7100-04","in 10mM DMSO","Calcium Channel","Neuronal Signaling","Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.",387.86,"10605-02-4",{"v":77,"d":"77.00"},198.53,{"v":5,"d":"5.00"},12.89,"http://selleckchem.com/products/Palmatine-chloride.html","C21H22NO4.Cl","Chloride","N/A","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC",1.488,4,0,4]
["S2399","Dihydromyricetin","a9","L7100-04","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2408","Cephalomannine","b9","L7100-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","Cephalomannine (Baccatin III) is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice.",{"v":831.9,"d":"831.90"},"71610-00-9",{"v":100,"d":"100.00"},120.21,"<1","N/A","http://selleckchem.com/products/cephalomannine.html","C45H53NO14","free base","Baccatin III","C/C=C(C)/C(=O)NC(C(O)C(=O)OC1CC2(O)C(OC(=O)C3=CC=CC=C3)C4C(C)(C(O)CC5OCC45OC(C)=O)C(=O)C(OC(C)=O)C(=C1C)C2(C)C)C6=CC=CC=C6",2.937,11,3,14]
["S2409","10-Deacetylbaccatin-III","c9","L7100-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","10-Deacetylbaccatin-III(10-DB III) is an antineoplastic agent and an anti-cancer intermediate.",544.59,"32981-86-5",{"v":109,"d":"109.00"},200.15,"<1","N/A","http://selleckchem.com/products/10-dab-10-deacetylbaccatin.html","C29H36O10","free base","10-DB III","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(O)C(=C(C(O)C3=O)C5(C)C)C",0.364,6,3,5]
["S2412","Genipin","d9","L7100-04","in 10mM DMSO","Apoptosis related","Apoptosis","Genipin((+)-Genipin) is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.",226.23,"6902-77-8",{"v":45,"d":"45.00"},198.91,"<1","N/A","http://selleckchem.com/products/genipin.html","C11H14O5","free base","(+)-Genipin","COC(=O)C1=COC(O)C2C1CC=C2CO",-0.319,3,1,3]
["S2448","Gambogic Acid","e9","L7100-04","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.",628.75,"2752-65-0",{"v":100,"d":"100.00"},159.05,"<1","N/A","http://selleckchem.com/products/gambogic-acid.html","C38H44O8","free base","Guttatic Acid, Guttic Acid, Beta-Guttiferrin","CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(=C2C=C1)O)C(=O)C4=CC5CC6C(C)(C)OC(C\\C=C(C)/C(O)=O)(C5=O)C46O3",6.957,6,1,8]
["S2449","Colforsin","f9","L7100-04","in 10mM DMSO","Autophagy,cAMP,FXR","GPCR & G Protein","Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.",{"v":410.5,"d":"410.50"},"66575-29-9",{"v":82,"d":"82.00"},199.76,"<1","N/A","http://selleckchem.com/products/forskolin.html","C22H34O7","free base","Forskolin, HL 362, Coleonol","CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C3(O)C(=O)CC(C)(OC13C)C=C",0.837,4,2,3]
["S2461","Domperidone","g9","L7100-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.",425.91,"57808-66-9",{"v":48,"d":"48.00"},{"v":112.7,"d":"112.70"},"<1","N/A","http://selleckchem.com/products/Domperidone(Motilium).html","C22H24ClN5O2","free base","N/A","ClC1=CC2=C(C=C1)N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)N2",2.453,2,2,5]
["S2467","Famciclovir","h9","L7100-04","in 10mM DMSO","Antiviral","Microbiology","Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.",321.34,"104227-87-4",{"v":64,"d":"64.00"},199.17,{"v":64,"d":"64.00"},199.17,"http://selleckchem.com/products/Famciclovir(Famvir).html","C14H19N5O4","free base","BRL-42810","CC(=O)OCC(CC[N]1C=NC2=CN=C(N)N=C12)COC(C)=O",-0.294,7,1,9]
["S2468","Fenbendazole","a10","L7100-04","in 10mM DMSO","Parasite","Microbiology","Fenbendazole(Fenbendazol,Phenbendasol) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/mL.",299.35,"43210-67-9",{"v":4,"d":"4.00"},13.36,"<1","N/A","http://selleckchem.com/products/Fenbendazole(Panacur).html","C15H13N3O2S","free base","Fenbendazol,Phenbendasol","COC(=O)NC1=NC2=C([NH]1)C=C(SC3=CC=CC=C3)C=C2",3.769,3,2,4]
["S2470","Fluocinolone Acetonide","b10","L7100-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.",{"v":452.5,"d":"452.50"},"67-73-2",{"v":90,"d":"90.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Fluocinolone-acetonide(Flucort-N).html","C24H30F2O6","free base","Flucort-N","CC1(C)OC2CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CO",0.995,4,2,2]
["S2475","Imatinib (STI571)","c10","L7100-04","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571,Gleevec, Glivec, CGP057148B) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.",{"v":493.6,"d":"493.60"},"152459-95-5",{"v":33,"d":"33.00"},66.86,"<1","N/A","http://selleckchem.com/products/Imatinib(STI571).html","C29H31N7O","free base","STI571,Gleevec, Glivec, CGP057148B","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",{"v":4.22,"d":"4.220"},4,2,7]
["S2487","Mycophenolic acid","d10","L7100-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dehydrogenase,Selection Antibiotics for Transfected Cell","Metabolism","Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.",320.34,"24280-93-1",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/Mycophenolic-acid(Mycophenolate).html","C17H20O6","free base","Mycophenolate, RS-61443","COC1=C(C)C2=C(C(=C1C\\C=C(/C)CCC(O)=O)O)C(=O)OC2",3.157,4,1,6]
["S2492","Novobiocin Sodium (NSC 2382)","e10","L7100-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.",634.61,"1476-53-5",{"v":100,"d":"100.00"},157.58,{"v":100,"d":"100.00"},157.58,"http://selleckchem.com/products/Novobiocin-sodium(Albamycin).html","C31H35N2O11.Na","Sodium Salt","Albamycin,Cathomycin,NSC 2382","[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=C(NC(=O)C4=CC=C([O-])C(=C4)CC=C(C)C)C(=O)OC3=C2C)O)OC1(C)C",2.747,8,4,9]
["S2503","Racecadotril","f10","L7100-04","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Racecadotril (Acetorphan) is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM.",385.48,"81110-73-8",{"v":22,"d":"22.00"},57.07,"<1","N/A","http://selleckchem.com/products/Racecadotril(Acetorphan).html","C21H23NO4S","free base","Acetorphan","CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2",3.128,4,1,11]
["S2504","Ribavirin (ICN-1229)","g10","L7100-04","in 10mM DMSO","Antiviral","Microbiology","Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.",244.21,"36791-04-5",{"v":49,"d":"49.00"},200.65,{"v":49,"d":"49.00"},200.65,"http://selleckchem.com/products/Ribavirin(Copegus).html","C8H12N4O5","free base","NSC-163039, RTCA, Tribavirin","NC(=O)C1=N[N](C=N1)C2OC(CO)C(O)C2O",-2.745,4,4,3]
["S2517","Maprotiline HCl","h10","L7100-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.",313.86,"10347-81-6",{"v":63,"d":"63.00"},200.73,"<1","N/A","http://selleckchem.com/products/Maprotiline-hydrochloride.html","C20H23N.HCl","Hydrochloride","N/A","Cl.CNCCCC12CCC(C3=CC=CC=C13)C4=C2C=CC=C4",4.498,0,1,4]
["S2533","Ritodrine HCl","a11","L7100-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.",323.81,"23239-51-2",{"v":65,"d":"65.00"},200.73,{"v":65,"d":"65.00"},200.73,"http://selleckchem.com/products/Ritodrine-hydrochloride-Yutopar.html","C17H21NO3.HCl","Hydrochloride","NSC 291565,DU 21220, Ritodrine","Cl.CC(NCCC1=CC=C(O)C=C1)C(O)C2=CC=C(O)C=C2",3.037,0,4,6]
["S2537","Secnidazole","b11","L7100-04","in 10mM DMSO","Anti-infection","Microbiology","Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.",185.18,"3366-95-8",{"v":37,"d":"37.00"},199.81,{"v":37,"d":"37.00"},199.81,"http://selleckchem.com/products/Secnidazole-Flagentyl.html","C7H11N3O3","free base","PM 185184, RP 14539","CC(O)C[N]1C(=NC=C1[N+]([O-])=O)C",{"v":0.04,"d":"0.040"},1,1,3]
["S2552","Azelastine HCl","c11","L7100-04","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.",418.36,"79307-93-0",{"v":28,"d":"28.00"},66.93,{"v":35,"d":"35.00"},83.66,"http://selleckchem.com/products/azelastine.html","C22H24ClN3O.HCl","Hydrochloride","N/A","Cl.CN1CCCC(CC1)N2N=C(CC3=CC=C(Cl)C=C3)C4=CC=CC=C4C2=O",4.476,2,0,3]
["S2561","Clomifene citrate","d11","L7100-04","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Clomifene citrate (NSC 35770, Clomiphene citrate) is a selective estrogen receptor modulator, used in the treatment of ovulation induction.",598.08,"50-41-9",{"v":120,"d":"120.00"},200.64,"<1","N/A","http://selleckchem.com/products/Clomifene-citrate-Serophene.html","C26H28ClNO.C6H8O7","Citrate","NSC 35770, Clomiphene citrate","CCN(CC)CCOC1=CC=C(C=C1)C(=C(Cl)/C2=CC=CC=C2)/C3=CC=CC=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",2.129,4,0,14]
["S2570","Prednisolone Acetate","e11","L7100-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.",402.48,"52-21-1",{"v":81,"d":"81.00"},201.25,"<1","N/A","http://selleckchem.com/products/Prednisolone-acetate-Omnipred.html","C23H30O6","free base","Omnipred,Prednisolone-21-acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C",1.639,4,1,4]
["S2584","Clobetasol propionate","f11","L7100-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.",466.97,"25122-46-7",{"v":93,"d":"93.00"},199.16,"<1","N/A","http://selleckchem.com/products/clobetasol-propionate.html","C25H32ClFO5","free base","CGP9555, CCl 4725","CCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.958,4,1,5]
["S2603","Tioxolone","g11","L7100-04","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.",168.17,"4991-65-5",{"v":34,"d":"34.00"},202.18,"<1","N/A","http://selleckchem.com/products/tioxolone.html","C7H4O3S","free base","Thioxolone","OC1=CC=C2SC(=O)OC2=C1",2.303,2,1,0]
["S2606","Mifepristone (RU486)","h11","L7100-04","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.",429.59,"84371-65-3",{"v":85,"d":"85.00"},197.86,"<1","N/A","http://selleckchem.com/products/Mifepristone(Mifeprex).html","C29H35NO2","free base","RU486, C-1073, RU 38486, RU-486, Mifegyne","CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)C5=CC=C(C=C5)N(C)C",5.655,1,0,3]
["S2617","TAK-733","a2","L7100-05","in 10mM DMSO","MEK","MAPK","TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.",504.23,"1035555-63-5",{"v":101,"d":"101.00"},200.31,"<1","N/A","http://selleckchem.com/products/tak-733.html","C17H15F2IN4O4","free base","N/A","CN1C(=O)C(=C(NC2=CC=C(I)C=C2F)C3=C1N=CN(CC(O)CO)C3=O)F",0.383,3,3,5]
["S2621","AZD5438","b2","L7100-05","in 10mM DMSO","CDK","Cell Cycle","AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β.",371.46,"602306-29-6",{"v":74,"d":"74.00"},199.21,"<1","N/A","http://selleckchem.com/products/AZD5438.html","C18H21N5O2S","free base","N/A","CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)[S](C)(=O)=O)C",2.966,5,1,5]
["S2622","PP121","c2","L7100-05","in 10mM DMSO","Bcr-Abl,DNA-PK,mTOR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.",319.36,"1092788-83-4",{"v":64,"d":"64.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/PP121.html","C17H17N7","free base","N/A","NC1=NC=NC2=C1C(=N[N]2C3CCCC3)C4=CN=C5[NH]C=CC5=C4",2.583,4,2,2]
["S2624","OSI-027","d2","L7100-05","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1","N/A","http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2626","Rabusertib (LY2603618)","e2","L7100-05","in 10mM DMSO","Apoptosis related,Autophagy,Chk","Cell Cycle","Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.",{"v":436.3,"d":"436.30"},"911222-45-2",{"v":13,"d":"13.00"},{"v":29.8,"d":"29.80"},"<1","N/A","http://selleckchem.com/products/LY2603618-IC-83.html","C18H22BrN5O3","free base","IC-83","CC1=NC=C(NC(=O)NC2=C(OCC3CNCCO3)C=C(C)C(=C2)Br)N=C1",{"v":1.58,"d":"1.580"},5,3,5]
["S2630","GW3965 HCl","f2","L7100-05","in 10mM DMSO","Liver X Receptor","Metabolism","GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.",618.51,"405911-17-3",{"v":16,"d":"16.00"},25.87,"<1","N/A","http://selleckchem.com/products/gw3965.html","C33H31ClF3NO3.HCl","hydrochloride","N/A","Cl.OC(=O)CC1=CC=CC(=C1)OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F",5.473,2,0,14]
["S2635","CCT128930","g2","L7100-05","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.",341.84,"885499-61-6",{"v":68,"d":"68.00"},198.92,"<1","N/A","http://selleckchem.com/products/cct128930.html","C18H20ClN5","free base","N/A","NC1(CCN(CC1)C2=C3C=C[NH]C3=NC=N2)CC4=CC=C(Cl)C=C4",2.813,2,2,3]
["S2639","SNX-2112 (PF-04928473)","h2","L7100-05","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.",464.48,"908112-43-6",{"v":93,"d":"93.00"},200.22,"<1","N/A","http://selleckchem.com/products/snx-2112.html","C23H27F3N4O3","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC(=C(C=C3)C(N)=O)NC4CCC(O)CC4",3.709,3,3,5]
["S2656","PF-04929113 (SNX-5422)","a3","L7100-05","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.",521.53,"908115-27-5",{"v":104,"d":"104.00"},199.41,"<1","N/A","http://selleckchem.com/products/pf-04929113.html","C25H30F3N5O4","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC=C(C(N)=O)C(=C3)NC4CCC(CC4)OC(=O)CN",3.126,5,3,8]
["S2658","Omipalisib (GSK2126458)","b3","L7100-05","in 10mM DMSO","Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.",{"v":505.5,"d":"505.50"},"1086062-66-9",{"v":100,"d":"100.00"},197.82,"<1","N/A","http://selleckchem.com/products/gsk2126458.html","C25H17F2N5O3S","free base","GSK458","COC1=NC=C(C=C1N[S](=O)(=O)C2=CC=C(F)C=C2F)C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3",3.705,7,1,6]
["S2661","WYE-125132 (WYE-132)","c3","L7100-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.",{"v":519.6,"d":"519.60"},"1144068-46-1",{"v":104,"d":"104.00"},200.15,"<1","N/A","http://selleckchem.com/products/wye-125132.html","C27H33N7O4","free base","N/A","CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7",2.093,7,2,4]
["S2662","Foscenvivint (ICG-001)","d3","L7100-05","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Wnt/beta-catenin","Stem Cells & Wnt","Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.",548.63,"780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry)",{"v":100,"d":"100.00"},182.27,"<1","N/A","http://selleckchem.com/products/icg-001.html","C33H32N4O4","free base","N/A","OC1=CC=C(CC2N3C(CN(CC4=CC=CC5=C4C=CC=C5)C2=O)N(CCC3=O)C(=O)NCC6=CC=CC=C6)C=C1",4.065,3,2,6]
["S2665","Ciprofibrate","e3","L7100-05","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","Ciprofibrate (Win-35833) is a peroxisome proliferator-activated receptor agonist.",289.15,"52214-84-3",{"v":58,"d":"58.00"},200.59,"<1","N/A","http://selleckchem.com/products/ciprofibrate.html","C13H14Cl2O3","free base","Win-35833","CC(C)(OC1=CC=C(C=C1)C2CC2(Cl)Cl)C(O)=O",2.954,2,0,4]
["S2666","PF-3845","f3","L7100-05","in 10mM DMSO","FAAH","Metabolism","PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.",456.46,"1196109-52-0",{"v":91,"d":"91.00"},199.36,"<1","N/A","http://selleckchem.com/products/pf-3845.html","C24H23F3N4O2","free base","N/A","FC(F)(F)C1=CN=C(OC2=CC(=CC=C2)CC3CCN(CC3)C(=O)NC4=CN=CC=C4)C=C1",{"v":4.55,"d":"4.550"},4,1,6]
["S2670","A-674563","g3","L7100-05","in 10mM DMSO","Akt,CDK,PKA","PI3K/Akt/mTOR","A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.",358.44,"552325-73-2",{"v":72,"d":"72.00"},200.87,{"v":72,"d":"72.00"},200.87,"http://selleckchem.com/products/a-674563.html","C22H22N4O","free base","N/A","CC1=N[NH]C2=C1C=C(C=C2)C3=CN=CC(=C3)OCC(N)CC4=CC=CC=C4",3.212,3,2,6]
["S2673","Trametinib (GSK1120212)","h3","L7100-05","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.",615.39,"871700-17-3",{"v":22,"d":"22.00"},35.75,"<1","N/A","http://selleckchem.com/products/gsk1120212-jtp-74057.html","C26H23FIN5O4","free base","JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(=CC=C5)NC(C)=O)C",3.176,4,2,5]
["S2680","Ibrutinib (PCI-32765)","a4","L7100-05","in 10mM DMSO","BTK,Target Protein Ligand","Angiogenesis","Ibrutinib (PCI-32765,Imbruvica) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.",{"v":440.5,"d":"440.50"},"936563-96-1",{"v":88,"d":"88.00"},199.77,"<1","N/A","http://selleckchem.com/products/pci-32765.html","C25H24N6O2","free base","PCI-32765,Imbruvica","NC1=C2C(=NC=N1)[N](N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)C5CCCN(C5)C(=O)C=C",3.985,5,1,5]
["S2683","CHIR-124","b4","L7100-05","in 10mM DMSO","Chk","Cell Cycle","CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.",419.91,"405168-58-3",{"v":7,"d":"7.00"},16.67,"<1","N/A","http://selleckchem.com/products/chir-124.html","C23H22ClN5O","free base","N/A","ClC1=CC2=C(NC(=O)C(=C2NC3CN4CCC3CC4)C5=NC6=C([NH]5)C=CC=C6)C=C1",3.089,2,3,3]
["S2685","KW-2478","c4","L7100-05","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.",574.66,"819812-04-9",{"v":115,"d":"115.00"},200.12,"<1","N/A","http://selleckchem.com/products/kw-2478.html","C30H42N2O9","free base","N/A","CCC1=C(CC(=O)N(CCOC)CCOC)C(=C(O)C=C1O)C(=O)C2=CC=C(OCCN3CCOCC3)C(=C2)OC",2.673,7,2,16]
["S2688","R547","d4","L7100-05","in 10mM DMSO","CDK","Cell Cycle","R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.",441.45,"741713-40-6",{"v":60,"d":"60.00"},135.92,"<1","N/A","http://selleckchem.com/products/r547.html","C18H21F2N5O4S","free base","Ro 4584820","COC1=CC=C(F)C(=C1C(=O)C2=C(N)N=C(NC3CCN(CC3)[S](C)(=O)=O)N=C2)F",1.133,6,2,6]
["S2689","WAY-600","e4","L7100-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",494.59,"1062159-35-6",{"v":22,"d":"22.00"},44.48,"<1","N/A","http://selleckchem.com/products/way-600.html","C28H30N8O","free base","N/A","C1CN(CCO1)C2=NC(=NC3=C2C=N[N]3C4CCN(CC4)CC5=CC=CN=C5)C6=CC7=C([NH]C=C7)C=C6",2.946,5,1,5]
["S2692","TG101209","f4","L7100-05","in 10mM DMSO","c-RET,FLT3,JAK","JAK/STAT","TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.",509.67,"936091-14-4",{"v":102,"d":"102.00"},200.13,"<1","N/A","http://selleckchem.com/products/tg101209.html","C26H35N7O2S","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(C)C(=N3)NC4=CC(=CC=C4)[S](=O)(=O)NC(C)(C)C)C=C2",4.659,4,3,8]
["S2693","Resminostat","g4","L7100-05","in 10mM DMSO","HDAC","Epigenetics","Resminostat (RAS2410) dose-dependently and selectively inhibits HDAC1/3/6 with IC50 of 42.5 nM/50.1 nM/71.8 nM, less potent to HDAC8 with IC50 of 877 nM.",{"v":349.4,"d":"349.40"},"864814-88-0",{"v":70,"d":"70.00"},200.34,"<1","N/A","http://selleckchem.com/products/resminostat-ras2410.html","C16H19N3O4S","free base","RAS2410","CN(C)CC1=CC=C(C=C1)[S](=O)(=O)[N]2C=CC(=C2)\\C=C\\C(=O)NO",1.837,3,1,6]
["S2696","Apitolisib (GDC-0980)","h4","L7100-05","in 10mM DMSO","Apoptosis related,Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.",{"v":498.6,"d":"498.60"},"1032754-93-0",{"v":20,"d":"20.00"},40.11,"<1","N/A","http://selleckchem.com/products/GDC-0980-RG7422.html","C23H30N8O3S","free base","RG7422, GNE 390","CC(O)C(=O)N1CCN(CC1)CC2=C(C)C3=NC(=NC(=C3S2)N4CCOCC4)C5=CN=C(N)N=C5",1.013,6,2,5]
["S2699","CH5132799","a5","L7100-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CH5132799 (MEN1611, PA799) inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.",377.42,"1007207-67-1",{"v":12,"d":"12.00"},31.79,"<1","N/A","http://selleckchem.com/products/ch5132799.html","C15H19N7O3S","free base","MEN1611, PA799","C[S](=O)(=O)N1CCC2=C(N=C(N=C12)N3CCOCC3)C4=CN=C(N)N=C4",0.095,7,1,3]
["S2700","Tirbanibulin","b5","L7100-05","in 10mM DMSO","Src","Angiogenesis","Tirbanibulin(KX2-391,KX 01), the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Phase 2.",431.53,"897016-82-9",{"v":86,"d":"86.00"},199.29,"<1","N/A","http://selleckchem.com/products/kx2-391.html","C26H29N3O3","free base","KX2-391,KX 01","O=C(CC1=CC=C(C=N1)C2=CC=C(OCCN3CCOCC3)C=C2)NCC4=CC=CC=C4",3.262,4,1,9]
["S2703","GSK1838705A","c5","L7100-05","in 10mM DMSO","ALK,IGF-1R","Protein Tyrosine Kinase","GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.",532.57,"1116235-97-2",{"v":107,"d":"107.00"},200.91,"<1","N/A","http://selleckchem.com/products/gsk1838705a.html","C27H29FN8O3","free base","N/A","CNC(=O)C1=C(F)C=CC=C1NC2=C3C=C[NH]C3=NC(=N2)NC4=C(OC)C=C5CCN(C(=O)CN(C)C)C5=C4",3.508,5,4,8]
["S2711","Dibenzazepine (YO-01027)","d5","L7100-05","in 10mM DMSO","Notch,Secretase","Proteases","Dibenzazepine (YO-01027, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM  in cell-free assays for APPL and Notch cleavage, respectively.",463.48,"209984-56-5",{"v":92,"d":"92.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/yo-01027.html","C26H23F2N3O3","free base","DBZ","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC2C(=O)N(C)C3=C(C=CC=C3)C4=C2C=CC=C4",3.277,3,2,5]
["S2718","TAK-901","e5","L7100-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.",504.64,"934541-31-8",{"v":101,"d":"101.00"},200.14,"<1","N/A","http://selleckchem.com/products/tak-901.html","C28H32N4O3S","free base","N/A","CC[S](=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C)C3=C2C4=C([NH]3)N=CC(=C4)C)C(=O)NC5CCN(C)CC5",4.056,4,2,5]
["S2719","AMG-900","f5","L7100-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.",503.58,"945595-80-2",{"v":100,"d":"100.00"},198.58,"<1","N/A","http://selleckchem.com/products/amg-900.html","C28H21N7OS","free base","N/A","CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=C(C=CC=N4)C5=NC(=NC=C5)N)C=C3)C6=C2C=CC=C6",6.487,6,2,6]
["S2722","JTC-801","g5","L7100-05","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.",447.96,"244218-51-7",{"v":90,"d":"90.00"},200.91,"<1","N/A","http://selleckchem.com/products/jtc-801.html","C26H25N3O2.HCl","Hydrochloride","N/A","Cl.CCC1=CC=C(OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C)C=C4N)C=C1",5.228,3,2,6]
["S2727","Dacomitinib (PF-00299804)","h5","L7100-05","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Dacomitinib (PF299804, PF299) is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.",469.94,"1110813-31-4",{"v":19,"d":"19.00"},40.43,"<1","N/A","http://selleckchem.com/products/pf299804.html","C24H25ClFN5O2","free base","PF299804,PF299","COC1=C(NC(=O)/C=C/CN2CCCCC2)C=C3C(=NC=NC3=C1)NC4=CC(=C(F)C=C4)Cl",5.055,4,2,7]
["S2728","AG-1478 (Tyrphostin AG-1478)","a6","L7100-05","in 10mM DMSO","EGFR,HCV,PI4K","Protein Tyrosine Kinase","AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).",315.75,"153436-53-4,175178-82-2",{"v":25,"d":"25.00"},79.18,"<1","N/A","http://selleckchem.com/products/ag-1478-tyrphostin-ag-1478.html","C16H14ClN3O2","free base","NSC 693255","COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)Cl",4.109,4,1,4]
["S2730","Crenolanib (CP-868596)","b6","L7100-05","in 10mM DMSO","FLT3,Mitophagy,PDGFR","Protein Tyrosine Kinase","Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.",443.54,"670220-88-9",{"v":88,"d":"88.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/crenolanib-cp-868596.html","C26H29N5O2","free base","ARO 002","CC1(COC1)COC2=CC3=C(C=C2)[N](C=N3)C4=NC5=C(C=CC=C5C=C4)N6CCC(N)CC6",3.192,4,1,5]
["S2731","AZ 3146","c6","L7100-05","in 10mM DMSO","MPS1","Cell Cycle","AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.",452.55,"1124329-14-1",{"v":28,"d":"28.00"},61.87,"<1","N/A","http://selleckchem.com/products/az-3146.html","C24H32N6O3","free base","N/A","COC1=C(NC2=NC3=C(C=N2)N(C)C(=O)N3C4CCCC4)C=CC(=C1)OC5CCN(C)CC5",3.416,5,1,6]
["S2736","Fedratinib (TG101348)","d6","L7100-05","in 10mM DMSO","Apoptosis related,c-RET,FLT3,JAK","JAK/STAT","Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.",524.68,"936091-26-8",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/Fedratinib-SAR302503-TG101348.html","C27H36N6O3S","free base","SAR302503","CC1=C(NC2=CC=CC(=C2)[S](=O)(=O)NC(C)(C)C)N=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=C1",5.123,5,3,11]
["S2740","GSK1070916","e6","L7100-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.",507.63,"942918-07-2",{"v":93,"d":"93.00"},{"v":183.2,"d":"183.20"},"<1","N/A","http://selleckchem.com/products/gsk1070916.html","C30H33N7O","free base","N/A","CC[N]1C=C(C2=C3C=C([NH]C3=NC=C2)C4=CC=CC(=C4)CN(C)C)C(=N1)C5=CC=C(NC(=O)N(C)C)C=C5",4.841,3,2,7]
["S2742","PHA-767491 HCl","f6","L7100-05","in 10mM DMSO","CDK","Cell Cycle","PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.",{"v":249.7,"d":"249.70"},"942425-68-5",{"v":24,"d":"24.00"},96.12,"<1","N/A","http://selleckchem.com/products/pha-767491.html","C12H11N3O.HCl","HCl","CAY10572, NMS 1116354","O=C1NCCC2=C1C=C([NH]2)C3=CC=NC=C3",1.252,2,2,1]
["S2743","PF-04691502","g6","L7100-05","in 10mM DMSO","Akt,Apoptosis related,mTOR,PI3K","PI3K/Akt/mTOR","PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.",425.48,"1013101-36-4",{"v":14,"d":"14.00"},{"v":32.9,"d":"32.90"},"<1","N/A","http://selleckchem.com/products/pf-04691502.html","C22H27N5O4","free base","PF4691502","COC1=CC=C(C=N1)C2=CC3=C(C)N=C(N)N=C3N(C4CCC(CC4)OCCO)C2=O",1.616,6,2,6]
["S2745","CHIR-98014","h6","L7100-05","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","CHIR-98014 (CT98014) is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.",486.31,"252935-94-7",{"v":8,"d":"8.00"},16.45,"<1","N/A","http://selleckchem.com/products/chir-98014.html","C20H17Cl2N9O2","free base","CT98014","NC1=NC(=CC=C1[N+]([O-])=O)NCCNC2=NC=C([N]3C=CN=C3)C(=N2)C4=CC=C(Cl)C=C4Cl",3.859,4,3,8]
["S2746","AZ 628","a7","L7100-05","in 10mM DMSO","Apoptosis related,Raf","MAPK","AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.",451.52,"878739-06-1",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://selleckchem.com/products/az628.html","C27H25N5O2","free base","N/A","CN1C=NC2=C(C=C(NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)C=C2)C1=O",{"v":4.57,"d":"4.570"},3,2,5]
["S2747","AMG-458","b7","L7100-05","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.",539.58,"913376-83-7",{"v":21,"d":"21.00"},38.92,"<1","N/A","http://selleckchem.com/products/amg458.html","C30H29N5O5","free base","N/A","COC1=CC2=NC=CC(=C2C=C1)OC3=CN=C(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)C5=CC=CC=C5)C=C3",3.125,6,1,8]
["S2749","BGT226 (NVP-BGT226) maleate","c7","L7100-05","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.",{"v":650.6,"d":"650.60"},"1245537-68-1",{"v":30,"d":"30.00"},46.11,"<1","N/A","http://selleckchem.com/products/nvp-bgt226.html","C28H25F3N6O2.C4H4O","maleate","N/A","COC1=NC=C(C=C1)C2=CC=C3N=CC4=C(N(C(=O)N4C)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F)C3=C2.OC(=O)\\C=C/C(O)=O",1.618,6,1,7]
["S2750","GW788388","d7","L7100-05","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.",425.48,"452342-67-5",{"v":15,"d":"15.00"},35.25,"<1","N/A","http://selleckchem.com/products/gw788388.html","C25H23N5O2","free base","N/A","O=C(NC1CCOCC1)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C[NH]N=C4C5=NC=CC=C5",2.862,5,2,5]
["S2751","Milciclib (PHA-848125)","e7","L7100-05","in 10mM DMSO","Autophagy,CDK","Cell Cycle","Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.",460.57,"802539-81-7",{"v":92,"d":"92.00"},199.75,"<1","N/A","http://selleckchem.com/products/pha-848125.html","C25H32N8O","free base","N/A","CNC(=O)C1=N[N](C)C2=C1C(C)(C)CC3=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N=C23",3.825,4,2,4]
["S2753","Tivantinib (ARQ 197)","f7","L7100-05","in 10mM DMSO","Apoptosis related,c-Met","Protein Tyrosine Kinase","Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.",369.42,"905854-02-6",{"v":73,"d":"73.00"},197.61,"<1","N/A","http://selleckchem.com/products/arq-197.html","C23H19N3O2","free base","N/A","O=C1NC(=O)C(C1C2=C[NH]C3=C2C=CC=C3)C4=C[N]5CCCC6=CC=CC4=C56",{"v":3.52,"d":"3.520"},2,2,2]
["S2757","Evofosfamide (TH-302)","g7","L7100-05","in 10mM DMSO","Others","Others","Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.",449.04,"918633-87-1",{"v":90,"d":"90.00"},200.43,{"v":10,"d":"10.00"},22.27,"http://selleckchem.com/products/th-302.html","C9H16Br2N5O4P","free base","Evofosfamide","C[N]1C(=CN=C1[N+]([O-])=O)CO[P](=O)(NCCBr)NCCBr",0.537,3,2,10]
["S2759","Fimepinostat (CUDC-907)","h7","L7100-05","in 10mM DMSO","Apoptosis related,HDAC,PI3K","Cytoskeletal Signaling","CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1.",508.55,"1339928-25-4",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/pi3k-hdac-inhibitor-i.html","C23H24N8O4S","free base","N/A","COC1=CC=C(C=N1)C2=NC3=C(SC(=C3)CN(C)C4=NC=C(C=N4)C(=O)NO)C(=N2)N5CCOCC5",2.303,8,1,7]
["S2761","NVP-BVU972","a8","L7100-05","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","NVP-BVU972 is a selective and potent Met (c-Met) inhibitor with IC50 of 14 nM.",340.38,"1185763-69-2",{"v":68,"d":"68.00"},199.78,"<1","N/A","http://selleckchem.com/products/nvp-bvu972.html","C20H16N6","free base","N/A","C[N]1C=C(C=N1)C2=N[N]3C(=CN=C3C=C2)CC4=CC=C5N=CC=CC5=C4",2.867,4,0,3]
["S2768","Dinaciclib (SCH727965)","b8","L7100-05","in 10mM DMSO","Caspase,CDK","Cell Cycle","Dinaciclib (SCH727965, PS-095760) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.",396.49,"779353-01-4",{"v":26,"d":"26.00"},65.58,"<1","N/A","http://selleckchem.com/products/dinaciclib-sch727965.html","C21H28N6O2","free base","PS-095760","CCC1=C2N=C(C=C(NCC3=CC=C[N+](=C3)[O-])[N]2N=C1)N4CCCCC4CCO",2.152,2,2,7]
["S2770","MK-5108 (VX-689)","c8","L7100-05","in 10mM DMSO","Aurora Kinase,Autophagy","Cell Cycle","MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.",461.94,"1010085-13-8",{"v":92,"d":"92.00"},199.16,"<1","N/A","http://selleckchem.com/products/mk-5108-vx-689.html","C22H21ClFN3O3S","free base","N/A","OC(=O)C1(CCC(CC1)OC2=C(F)C(=CC=C2)Cl)CC3=CC=CC(=N3)NC4=NC=CS4",5.574,4,1,7]
["S2772","Dalcetrapib (JTT-705)","d8","L7100-05","in 10mM DMSO","CETP","Metabolism","Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3.",389.59,"211513-37-0",{"v":78,"d":"78.00"},200.21,"<1","N/A","http://selleckchem.com/products/dalcetrapib-jtt-705.html","C23H35NO2S","free base","RO4607381","CCC(CC)CC1(CCCCC1)C(=O)NC2=C(SC(=O)C(C)C)C=CC=C2",7.025,2,1,9]
["S2774","MK-2461","e8","L7100-05","in 10mM DMSO","c-Met,FGFR,PDGFR,RON","Protein Tyrosine Kinase","MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.",495.55,"917879-39-1",{"v":99,"d":"99.00"},199.78,"<1","N/A","http://selleckchem.com/products/mk-2461.html","C24H25N5O5S","free base","N/A","CN(CC1COCCO1)[S](=O)(=O)NC2=CC3=C(C=C2)C=CC4=C(C=C(C=N4)C5=C[N](C)N=C5)C3=O",0.924,7,1,6]
["S2775","Nocodazole (R17934)","f8","L7100-05","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,CRISPR/Cas9,Microtubule Associated","Cytoskeletal Signaling","Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.",301.32,"31430-18-9",{"v":7,"d":"7.00"},23.23,"<1","N/A","http://selleckchem.com/products/nocodazole.html","C14H11N3O3S","free base","Oncodazole, NSC238159","COC(=O)NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CS3",3.008,4,2,4]
["S2778","GW842166X","g8","L7100-05","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.",449.25,"666260-75-9",{"v":20,"d":"20.00"},44.52,"<1","N/A","http://selleckchem.com/products/gw-842166x.html","C18H17Cl2F3N4O2","free base","N/A","FC(F)(F)C1=NC(=NC=C1C(=O)NCC2CCOCC2)NC3=CC=C(Cl)C=C3Cl",4.449,4,2,6]
["S2779","M344","h8","L7100-05","in 10mM DMSO","HDAC","Cytoskeletal Signaling","M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.",307.39,"251456-60-7",{"v":62,"d":"62.00"},{"v":201.7,"d":"201.70"},"<1","N/A","http://selleckchem.com/products/m344.html","C16H25N3O3","free base","N/A","CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO",2.004,2,2,9]
["S2780","I-BET151 (GSK1210151A)","a9","L7100-05","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","I-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM in cell-free assays, respectively.",415.44,"1300031-49-5",{"v":83,"d":"83.00"},199.79,"<1","N/A","http://www.selleck.cn/products/i-bet151-gsk1210151a.html","C23H21N5O3","Free Base","N/A","COC1=C(C=C2N=CC3=C(N(C(C)C4=CC=CC=N4)C(=O)N3)C2=C1)C5=C(C)ON=C5C",2.601,6,1,4]
["S2783","Vistusertib (AZD2014)","b9","L7100-05","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.",462.54,"1009298-59-2",{"v":38,"d":"38.00"},82.16,"<1","N/A","http://selleckchem.com/products/azd2014.html","C25H30N6O3","free base","N/A","CNC(=O)C1=CC=CC(=C1)C2=CC=C3C(=N2)N=C(N=C3N4CCOCC4C)N5CCOCC5C",3.103,6,1,4]
["S2784","TAK-285","c9","L7100-05","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.",547.96,"871026-44-7",{"v":110,"d":"110.00"},200.74,"<1","N/A","http://selleckchem.com/products/tak-285.html","C26H25ClF3N5O3","free base","N/A","CC(C)(O)CC(=O)NCC[N]1C=CC2=C1C(=NC=N2)NC3=CC=C(OC4=CC=CC(=C4)C(F)(F)F)C(=C3)Cl",5.586,4,2,10]
["S2785","A-803467","d9","L7100-05","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.",357.79,"944261-79-4",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/a-803467.html","C19H16ClNO4","free base","N/A","COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(Cl)C=C3)OC",4.451,4,1,5]
["S2790","Istradefylline","e9","L7100-05","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.",384.43,"155270-99-8",{"v":6,"d":"6.00"},15.61,"<1","N/A","http://selleckchem.com/products/istradefylline-kw-6002.html","C20H24N4O4","free base","KW-6002","CCN1C(=O)N(CC)C2=C([N](C)C(=N2)\\C=C\\C3=CC=C(OC)C(=C3)OC)C1=O",2.957,5,0,6]
["S2792","Torcetrapib","f9","L7100-05","in 10mM DMSO","CETP","Metabolism","Torcetrapib (CP-529414) is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3.",600.47,"262352-17-0",{"v":120,"d":"120.00"},199.84,"<1","N/A","http://selleckchem.com/products/torcetrapib-cp-529414.html","C26H25F9N2O4","free base","CP-529414","CCOC(=O)N1C(CC)CC(N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C(=O)OC)C3=C1C=CC(=C3)C(F)(F)F",7.345,4,0,10]
["S2796","WP1066","g9","L7100-05","in 10mM DMSO","Apoptosis related,JAK,STAT","JAK/STAT","WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.",356.22,"857064-38-1",{"v":71,"d":"71.00"},199.32,"<1","N/A","http://selleckchem.com/products/wp1066.html","C17H14BrN3O","free base","N/A","CC(NC(=O)\\C(=C\\C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",3.566,2,1,4]
["S2797","Lonafarnib (SCH66336)","h9","L7100-05","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2799","Daporinad","a10","L7100-05","in 10mM DMSO","Autophagy,NAMPT,Transferase","Metabolism","Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.",391.51,"658084-64-1",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://www.selleck.cn/products/apo866-fk866.html","C24H29N3O2","Free Base","FK866, APO866","O=C(NCCCCC1CCN(CC1)C(=O)C2=CC=CC=C2)/C=C/C3=CC=CN=C3",3.269,3,1,8]
["S2801","AZD4547","b10","L7100-05","in 10mM DMSO","FGFR","Angiogenesis","AZD4547 (ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.",463.57,"1035270-39-3",{"v":92,"d":"92.00"},198.46,"<1","N/A","http://selleckchem.com/products/azd4547.html","C26H33N5O3","free base","ABSK 091","COC1=CC(=CC(=C1)OC)CCC2=CC(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CC(C)NC(C)C4",4.204,4,3,8]
["S2803","Galeterone","c10","L7100-05","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Endocrinology & Hormones","Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.",388.55,"851983-85-2",{"v":24,"d":"24.00"},61.77,"<1","N/A","http://selleckchem.com/products/galeterone-tok-001.html","C26H32N2O","free base","TOK-001","CC12CCC(O)CC1=CCC3C2CCC4(C)C3CC=C4[N]5C=NC6=C5C=CC=C6",4.897,1,1,1]
["S2806","CEP-33779","d10","L7100-05","in 10mM DMSO","JAK","JAK/STAT","CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM, >40- and >800-fold versus JAK1 and TYK2.",462.57,"1257704-57-6",{"v":36,"d":"36.00"},77.83,"<1","N/A","http://selleckchem.com/products/cep33779.html","C24H26N6O2S","free base","N/A","CN1CCN(CC1)C2=CC=CC(=C2)NC3=N[N]4C=CC=C(C5=CC=C(C=C5)[S](C)(=O)=O)C4=N3",{"v":3.86,"d":"3.860"},4,1,5]
["S2808","Ipatasertib (GDC-0068)","e10","L7100-05","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Ipatasertib (GDC-0068, RG7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.",{"v":458,"d":"458.00"},"1001264-89-6",{"v":92,"d":"92.00"},200.87,"<1","N/A","http://selleckchem.com/products/gdc-0068.html","C24H32ClN5O2","free base","RG7440","CC(C)NCC(C(=O)N1CCN(CC1)C2=C3C(C)CC(O)C3=NC=N2)C4=CC=C(Cl)C=C4",3.102,3,2,6]
["S2811","Sapanisertib (MLN0128)","f10","L7100-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.",309.33,"1224844-38-5",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://selleckchem.com/products/ink128.html","C15H15N7O","free base","INK 128,TAK-228","CC(C)[N]1N=C(C2=CC3=C(OC(=N3)N)C=C2)C4=C(N)N=CN=C14",1.886,5,2,2]
["S2814","Alpelisib (BYL719)","g10","L7100-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.",441.47,"1217486-61-7",{"v":88,"d":"88.00"},199.33,"<1","N/A","http://selleckchem.com/products/byl719.html","C19H22F3N5O2S","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CC(=NC=C3)C(C)(C)C(F)(F)F",2.826,4,2,5]
["S2817","Torin 2","h10","L7100-05","in 10mM DMSO","Apoptosis related,ATM/ATR,Autophagy,DNA-PK,mTOR","PI3K/Akt/mTOR","Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.",{"v":432.4,"d":"432.40"},"1223001-51-1",{"v":20,"d":"20.00"},46.25,"<1","N/A","http://selleckchem.com/products/torin-2.html","C24H15F3N4O","free base","N/A","NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(=O)C=C4)C5=CC=CC(=C5)C(F)(F)F)C3=C2",4.323,3,1,3]
["S2818","Tacedinaline (CI994)","a11","L7100-05","in 10mM DMSO","HDAC","Epigenetics","Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.",{"v":269.3,"d":"269.30"},"112522-64-2",{"v":54,"d":"54.00"},200.52,"<1","N/A","http://selleckchem.com/products/ci994-tacedinaline.html","C15H15N3O2","free base","PD-123654, GOE-5549, Acetyldinaline","CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N)C=CC=C2",0.988,2,3,3]
["S2819","AM251","b11","L7100-05","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain.",555.24,"183232-66-8",{"v":40,"d":"40.00"},72.04,"<1","N/A","http://selleckchem.com/products/am251.html","C22H21Cl2IN4O","free base","N/A","CC1=C([N](N=C1C(=O)NN2CCCCC2)C3=CC=C(Cl)C=C3Cl)C4=CC=C(I)C=C4",6.527,2,1,4]
["S2820","TAE226 (NVP-TAE226)","c11","L7100-05","in 10mM DMSO","Apoptosis related,FAK,Pyk2","Angiogenesis","TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.",468.94,"761437-28-9",{"v":94,"d":"94.00"},200.45,"<1","N/A","http://selleckchem.com/products/nvp-tae226.html","C23H25ClN6O3","free base","N/A","CNC(=O)C1=C(NC2=C(Cl)C=NC(=N2)NC3=C(OC)C=C(C=C3)N4CCOCC4)C=CC=C1",3.917,5,3,7]
["S2821","RG108","d11","L7100-05","in 10mM DMSO","DNA Methyltransferase","Epigenetics","RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.",334.33,"48208-26-0",{"v":67,"d":"67.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/rg108.html","C19H14N2O4","free base","N-Phthalyl-L-tryptophan","OC(=O)C(CC1=C[NH]C2=C1C=CC=C2)N3C(=O)C4=CC=CC=C4C3=O",2.677,3,1,4]
["S2823","Tideglusib (NP031112)","e11","L7100-05","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.",334.39,"865854-05-3",{"v":8,"d":"8.00"},23.92,"<1","N/A","http://selleckchem.com/products/tideglusib.html","C19H14N2O2S","free base","NP-12","O=C1SN(C(=O)N1CC2=CC=CC=C2)C3=C4C=CC=CC4=CC=C3",{"v":4.63,"d":"4.630"},2,0,3]
["S2824","TPCA-1","f11","L7100-05","in 10mM DMSO","Apoptosis related,IκB/IKK,NF-κB,STAT","NF-κB","TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.",279.29,"507475-17-4",{"v":56,"d":"56.00"},200.51,"<1","N/A","http://selleckchem.com/products/tpca-1.html","C12H10FN3O2S","free base","GW683965","NC(=O)NC1=C(C=C(S1)C2=CC=C(F)C=C2)C(N)=O",1.544,2,3,3]
["S2825","ML133 HCl","g11","L7100-05","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.",313.82,"1222781-70-5",{"v":63,"d":"63.00"},200.75,"<1","N/A","http://selleckchem.com/products/Ml-133-hcl.html","C19H19NO.HCl","Hydrochloride","N/A","Cl.COC1=CC=C(CNCC2=CC=CC3=C2C=CC=C3)C=C1",4.225,1,1,5]
["S2842","SAR131675","h11","L7100-05","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.",358.39,"1433953-83-3",{"v":30,"d":"30.00"},83.71,"<1","N/A","http://selleckchem.com/products/sar131675.html","C18H22N4O4","free base","N/A","CCN1C(=C(C(=O)NC)C(=O)C2=CC=C(N=C12)C#CC(C)(O)COC)N",0.769,4,2,6]
["S2843","BI-D1870","a2","L7100-06","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2845","Semaxanib (SU5416)","b2","L7100-06","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.",238.28,"204005-46-9",{"v":22,"d":"22.00"},92.33,"<1","N/A","http://selleckchem.com/products/semaxanib-su5416.html","C15H14N2O","free base","semaxinib","CC1=CC(=C([NH]1)/C=C/2C(=O)NC3=CC=CC=C23)C",2.747,1,2,1]
["S2853","Carfilzomib (PR-171)","c2","L7100-06","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,Proteasome","Proteases","Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.",719.91,"868540-17-4",{"v":50,"d":"50.00"},69.45,"<1","N/A","http://selleckchem.com/products/carfilzomib-pr-171.html","C40H57N5O7","free base","N/A","CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)C4(C)CO4",3.799,7,4,20]
["S2858","StemRegenin 1 (SR1)","d2","L7100-06","in 10mM DMSO","AhR","Metabolism","StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.",429.54,"1227633-49-9",{"v":86,"d":"86.00"},200.21,"<1","N/A","http://selleckchem.com/products/stemRegenin-1.html","C24H23N5OS","free base","N/A","CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=CC=C(O)C=C3)C4=CSC5=CC=CC=C45",{"v":5.19,"d":"5.190"},3,2,6]
["S2859","Golvatinib (E7050)","e2","L7100-06","in 10mM DMSO","c-Met,VEGFR","Protein Tyrosine Kinase","Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2.",633.69,"928037-13-2",{"v":20,"d":"20.00"},31.56,"<1","N/A","http://selleckchem.com/products/golvatinib-e7050.html","C33H37F2N7O4","free base","N/A","CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4)F",3.173,5,3,8]
["S2860","IEM 1754 2HBr","f2","L7100-06","in 10mM DMSO","GluR","Neuronal Signaling","IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.",412.25,"162831-31-4",{"v":82,"d":"82.00"},198.91,{"v":82,"d":"82.00"},198.91,"http://selleckchem.com/products/iem-1754-dihydrobromide.html","C16H30N2.2HBr","DihydrobroMide","N/A","Br.Br.NCCCCCNC[C]12C[CH]3C[CH]([CH2]C([CH2]3)C1)C2",{"v":3.51,"d":"3.510"},0,2,7]
["S2862","VU 0364770","g2","L7100-06","in 10mM DMSO","GluR","Neuronal Signaling","VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.",232.67,"61350-00-3",{"v":47,"d":"47.00"},{"v":202,"d":"202.00"},"<1","N/A","http://selleckchem.com/products/vu-0364770.html","C12H9ClN2O","free base","N/A","ClC1=CC(=CC=C1)NC(=O)C2=NC=CC=C2",2.557,2,1,2]
["S2867","WHI-P154","h2","L7100-06","in 10mM DMSO","EGFR,JAK","JAK/STAT","WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.",{"v":376.2,"d":"376.20"},"211555-04-3",{"v":75,"d":"75.00"},199.36,"<1","N/A","http://selleckchem.com/products/whi-p154.html","C16H14BrN3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC=C(O)C(=C3)Br",{"v":3.95,"d":"3.950"},4,2,4]
["S2882","IKK-16 (IKK Inhibitor VII)","a3","L7100-06","in 10mM DMSO","IκB/IKK,LRRK2","NF-κB","IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.",483.63,"873225-46-8",{"v":97,"d":"97.00"},200.57,"<1","N/A","http://selleckchem.com/products/ikk-16.html","C28H29N5OS","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC=C(NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5)C=C3",5.208,3,1,5]
["S2884","Acesulfame Potassium","b3","L7100-06","in 10mM DMSO","Others","Others","Acesulfame potassium is a non-nutritive sweetener.",202.25,"55589-62-3",{"v":40,"d":"40.00"},197.78,{"v":40,"d":"40.00"},197.78,"http://selleckchem.com/products/acesulfame-potassium.html","C4H5NO4S.K","Potassium Salt","N/A","[KH].CC1=CC(=O)N[S](=O)(=O)O1",-0.858,2,1,0]
["S2891","GW441756","c3","L7100-06","in 10mM DMSO","Apoptosis related,Caspase,Trk receptor","Protein Tyrosine Kinase","GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.",{"v":275.3,"d":"275.30"},"504433-23-2",{"v":25,"d":"25.00"},90.81,"<1","N/A","http://selleckchem.com/products/gw-441756.html","C17H13N3O","free base","N/A","C[N]1C=C(C=C2C(=O)NC3=CC=CN=C23)C4=C1C=CC=C4",2.508,2,1,1]
["S2892","VU 0361737","d3","L7100-06","in 10mM DMSO","GluR","Neuronal Signaling","VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.",262.69,"1161205-04-4",{"v":53,"d":"53.00"},201.76,"<1","N/A","http://selleckchem.com/products/vu-0361737.html","C13H11ClN2O2","free base","N/A","COC1=CC(=CC=C1Cl)NC(=O)C2=NC=CC=C2",{"v":2.54,"d":"2.540"},3,1,3]
["S2895","Tyrphostin 9","e3","L7100-06","in 10mM DMSO","EGFR,PDGFR","Protein Tyrosine Kinase","Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.",282.38,"10537-47-0",{"v":56,"d":"56.00"},198.31,"<1","N/A","http://selleckchem.com/products/tyrphostin-9-sf-6847.html","C18H22N2O","free base","SF 6847, RG-50872","CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N",4.574,0,1,3]
["S2897","ZM 306416","f3","L7100-06","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","ZM 306416 (CB 676475) is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.",333.74,"690206-97-4",{"v":67,"d":"67.00"},200.76,"<1","N/A","http://selleckchem.com/products/zm-306416.html","C16H13ClFN3O2","free base","CB 676475","COC1=CC2=NC=NC(=C2C=C1OC)NC3=C(F)C=C(Cl)C=C3",4.314,4,1,4]
["S2900","Cobicistat (GS-9350)","g3","L7100-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.",776.02,"1004316-88-4",{"v":100,"d":"100.00"},128.86,"<1","N/A","http://selleckchem.com/products/cobicistat-gs-9350.html","C40H53N7O5S2","free base","N/A","CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5",4.765,7,3,20]
["S2901","CCG 50014","h3","L7100-06","in 10mM DMSO","RGS","GPCR & G Protein","CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.",316.35,"883050-24-6",{"v":63,"d":"63.00"},199.15,"<1","N/A","http://selleckchem.com/products/ccg-50014.html","C16H13FN2O2S","free base","N/A","CC1=CC=C(C=C1)N2SC(=O)N(CC3=CC=C(F)C=C3)C2=O",4.414,2,0,3]
["S2904","PF-477736","a4","L7100-06","in 10mM DMSO","Chk","Cell Cycle","PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.",419.48,"952021-60-2",{"v":6,"d":"6.00"},{"v":14.3,"d":"14.30"},"<1","N/A","http://selleckchem.com/products/pf-477736.html","C22H25N7O2","free base","PF-736, PF-00477736","C[N]1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(N)C5CCCCC5)[NH]2",2.089,4,4,4]
["S2913","BAY 11-7082","b4","L7100-06","in 10mM DMSO","Apoptosis related,DUB,IκB/IKK","NF-κB","BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.",207.25,"19542-67-7",{"v":41,"d":"41.00"},197.83,"<1","N/A","http://selleckchem.com/products/bay-11-7082-bay-11-7821.html","C10H9NO2S","free base","BAY 11-7821","CC1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",1.721,2,0,2]
["S2914","Dapivirine (TMC120)","c4","L7100-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.",{"v":329.4,"d":"329.40"},"244767-67-7",{"v":34,"d":"34.00"},103.22,"<1","N/A","http://selleckchem.com/products/dapivirine.html","C20H19N5","free base","N/A","CC1=CC(=C(NC2=CC=NC(=N2)NC3=CC=C(C=C3)C#N)C(=C1)C)C",5.549,2,2,4]
["S2921","PF-4981517","d4","L7100-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","PF-4981517 (CYP3cide, PF-04981517) is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7.",456.59,"1390637-82-7",{"v":91,"d":"91.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/pf-4981517.html","C26H32N8","free base","CYP3cide, PF-04981517","C[N]1N=CC(=C1C2=CC=C(C)C=C2)C3=N[N](C)C4=NC=NC(=C34)N5CCC(C5)N6CCCCC6",4.659,4,0,4]
["S2922","Icotinib (BPI-2009H)","e4","L7100-06","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Icotinib (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).",391.42,"610798-31-7",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/icotinib.html","C22H21N3O4","free base","BPI-2009H","C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C4OCCOCCOCCOC4=C3",4.128,6,1,2]
["S2924","Laduviglusib (CHIR-99021) HCl","f4","L7100-06","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.",{"v":501.8,"d":"501.80"},"1797989-42-4",{"v":93,"d":"93.00"},185.33,"<1","N/A","http://selleckchem.com/products/chir-99021-ct99021-hcl.html","C22H18Cl2N8.HCl","Hydrochloride","CT99021 HCl","Cl.CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=NC=C(C=C3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.858,4,3,7]
["S2925","Evacetrapib (LY2484595)","g4","L7100-06","in 10mM DMSO","CETP","Metabolism","Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.",638.65,"1186486-62-3",{"v":12.8,"d":"12.80"},20.04,"<1","N/A","http://selleckchem.com/products/evacetrapib-ly2484595.html","C31H36F6N6O2","free base","N/A","C[N]1N=NC(=N1)N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3CCCN(CC4CCC(CC4)C(O)=O)C5=C3C=C(C)C=C5C",8.617,4,0,9]
["S2928","TAK-715","h4","L7100-06","in 10mM DMSO","p38 MAPK","MAPK","TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.",399.51,"303162-79-0",{"v":80,"d":"80.00"},200.25,"<1","N/A","http://selleckchem.com/products/tak-715.html","C24H21N3OS","free base","N/A","CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C",5.629,3,1,5]
["S3012","Pazopanib","a5","L7100-06","in 10mM DMSO","Autophagy,Cathepsin B,c-Kit,CSF-1R,Cysteine Protease,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.",437.52,"444731-52-6",{"v":87,"d":"87.00"},198.85,"<1","N/A","http://selleckchem.com/products/pazopanib.html","C21H23N7O2S","Free Base","GW786034","C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",3.741,5,2,5]
["S3017","Aspirin (NSC 27223)","b5","L7100-06","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3019","Ciclopirox ethanolamine","c5","L7100-06","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator.",268.35,"41621-49-2",{"v":6,"d":"6.00"},22.36,"<1","N/A","http://selleckchem.com/products/ciclopirox-ethanolamine.html","C12H17NO2.C2H7NO","Ethanolamine","Ciclopirox olamine, HOE 296,Ciclopiroxolamine","CC1=CC(=O)N(O)C(=C1)C2CCCCC2.NCCO",1.302,1,2,2]
["S3022","Cabazitaxel (XRP6258)","d5","L7100-06","in 10mM DMSO","Autophagy,Microtubule Associated","Cytoskeletal Signaling","Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.",835.93,"183133-96-2",{"v":100,"d":"100.00"},119.63,"<1","N/A","http://selleckchem.com/products/cabazitaxel-jevtana.html","C45H57NO14","free base","RPR-116258A, TXD 258, Taxoid XRP6258","COC1CC2OCC2(OC(C)=O)C3C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(OC)C(=O)C13C)C5(C)C)C",3.403,12,2,15]
["S3027","Fenoprofen calcium hydrate","e5","L7100-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).",558.63,"71720-56-4, 53746-45-5",{"v":48,"d":"48.00"},85.92,"<1","N/A","http://selleckchem.com/products/fenoprofen-calcium-hydrate.html","C30H30CaO8","Calcium dihydrate salt","Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate","O.O.CC(C(=O)O[Ca]OC(=O)C(C)C1=CC=CC(=C1)OC2=CC=CC=C2)C3=CC=CC(=C3)OC4=CC=CC=C4",6.802,6,0,12]
["S3030","Niclosamide (BAY2353)","f5","L7100-06","in 10mM DMSO","Autophagy,STAT","JAK/STAT","Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).",327.12,"50-65-7",{"v":8,"d":"8.00"},24.46,"<1","N/A","http://www.selleck.cn/products/niclosamide-niclocide.html","C13H8Cl2N2O4","Free Base","Niclocide, NSC 178296","OC1=CC=C(Cl)C=C1C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.595,1,2,3]
["S3032","Bindarit (AF 2838)","g5","L7100-06","in 10mM DMSO","CCR,Immunology & Inflammation related","Immunology & Inflammation","Bindarit (AF 2838) exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.",324.37,"130641-38-2",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/bindarit.html","C19H20N2O3","free base","AF 2838","CC(C)(OCC1=N[N](CC2=CC=CC=C2)C3=C1C=CC=C3)C(O)=O",3.559,3,0,6]
["S3035","Daunorubicin (RP 13057) HCl","h5","L7100-06","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,COVID-19,DNA/RNA Synthesis,Topoisomerase","DNA Damage/DNA Repair","Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.",563.98,"23541-50-6",{"v":100,"d":"100.00"},177.31,{"v":100,"d":"100.00"},177.31,"http://selleckchem.com/products/daunorubicin-hcl-daunomycin-hcl.html","C27H29NO10.HCl","Hydrochloride","Daunomycin HCl, Rubidomycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(C)=O)O)C(=O)C2=CC=C1",{"v":1.01,"d":"1.010"},6,4,4]
["S3057","Azilsartan Medoxomil","a6","L7100-06","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.",568.53,"863031-21-4",{"v":114,"d":"114.00"},200.52,"<1","N/A","http://selleckchem.com/products/azilsartan-medoxomil-tak-491.html","C30H24N4O8","free base","TAK-491","CCOC1=NC2=CC=CC(=C2[N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)OCC6=C(C)OC(=O)O6",{"v":5.27,"d":"5.270"},10,1,10]
["S3078","Beclomethasone dipropionate","b6","L7100-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Beclomethasone dipropionate(Beclovent,Beconase,Vancenase)  is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.",521.04,"5534-09-8",{"v":104,"d":"104.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/beclomethasone-dipropionate.html","C28H37ClO7","free base","Beclometasone dipropionate,Beclovent,Beconase,Vancenase","CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC12C",4.064,6,1,8]
["S3081","Ulipristal Acetate (CDB 2914)","c6","L7100-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.",475.62,"126784-99-4",{"v":83,"d":"83.00"},191.43,"<1","N/A","http://selleckchem.com/products/ulipristal.html","C30H37NO4","free base","HRP 2000, RU 44675","CN(C)C1=CC=C(C=C1)C2CC3(C)C(CCC3(OC(C)=O)C(C)=O)C4CCC5=CC(=O)CCC5=C24",4.309,2,0,3]
["S3105","Nadifloxacin","d6","L7100-06","in 10mM DMSO","Antibiotics","Microbiology","Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.",360.38,"124858-35-1",{"v":20,"d":"20.00"},{"v":55.5,"d":"55.50"},"<1","N/A","http://selleckchem.com/products/nadifloxacin.html","C19H21FN2O4","free base","OPC-7251","CC1CCC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCC(O)CC4)F",1.865,2,1,2]
["S3124","Dexamethasone Acetate","e6","L7100-06","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3144","Darifenacin HBr","f6","L7100-06","in 10mM DMSO","AChR","Neuronal Signaling","Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.",507.46,"133099-07-7",{"v":100,"d":"100.00"},197.06,"<1","N/A","http://selleckchem.com/products/darifenacin-hydrobromide.html","C28H30N2O2.HBr","HBr","UK-88525","Br.NC(=O)C(C1CCN(CCC2=CC=C3OCCC3=C2)C1)(C4=CC=CC=C4)C5=CC=CC=C5",5.048,2,1,7]
["S3172","Anagrelide HCl","g6","L7100-06","in 10mM DMSO","PDE","Metabolism","Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.",292.55,"58579-51-4",{"v":14,"d":"14.00"},47.86,"<1","N/A","http://selleckchem.com/products/anagrelide-hydrochloride.html","C10H7Cl2N3O.HCl","Hydrochloride","BL-4162A,BMY 26538-01","Cl.ClC1=CC=C2NC3=NC(=O)CN3CC2=C1Cl",2.347,2,1,0]
["S3604","Triptolide (PG490)","h6","L7100-06","in 10mM DMSO","ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-κB","NF-κB","Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.",{"v":360.4,"d":"360.40"},"38748-32-2",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/triptolide.html","C20H24O6","free base","NSC 163062","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2O",0.872,5,1,1]
["S3653","Spermidine trihydrochloride","a7","L7100-06","in 10mM DMSO","Autophagy,NMDAR","Neuronal Signaling","Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).",254.63,"334-50-9",{"v":30,"d":"30.00"},117.82,{"v":50,"d":"50.00"},196.36,"http://selleckchem.com/products/spermidine-trihydrochloride.html","C7H19N3.3HCl","trihydrochloride","4-Azaoctamethylenediamine trihydrochloride","Cl.Cl.Cl.NCCCCNCCCN",-0.024,0,3,7]
["S3659","Fludrocortisone acetate","b7","L7100-06","in 10mM DMSO","Others","Others","Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.",422.49,"514-36-3",{"v":84,"d":"84.00"},198.82,"<1","N/A","http://selleckchem.com/products/fludrocortisone-acetate.html","C23H31FO6","free base","9α-fluorocortisol acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC12C",1.791,4,1,4]
["S3665","Trolox","c7","L7100-06","in 10mM DMSO","Vitamin","Metabolism","Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.",250.29,"53188-07-1",{"v":50,"d":"50.00"},199.77,"<1","N/A","http://selleckchem.com/products/trolox.html","C14H18O4","free base","N/A","CC1=C(C)C2=C(CCC(C)(O2)C(O)=O)C(=C1O)C",3.489,2,1,1]
["S3669","Carmustine","d7","L7100-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.",214.05,"154-93-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carmustine.html","C5H9Cl2N3O2","free base","bis-chloroethylnitrosourea, BCNU, BiCNU","ClCCNC(=O)N(CCCl)N=O",1.201,2,1,5]
["S3731","Tipiracil hydrochloride","e7","L7100-06","in 10mM DMSO","Phosphorylase,Thymidylate Synthase","Metabolism","Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.",279.12,"183204-72-0",{"v":8,"d":"8.00"},28.66,{"v":55,"d":"55.00"},197.05,"http://selleckchem.com/products/tipiracil-hydrochloride.html","C9H11ClN4O2.HCl","hydrochloride","MA-1 hydrochloride","Cl.ClC1=C(CN2CCCC2=N)NC(=O)NC1=O",-0.388,2,2,2]
["S3751","Quinidine hemisulfate hydrate","f7","L7100-06","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.",391.47,"6591-63-5",{"v":100,"d":"100.00"},154.12,{"v":9,"d":"9.00"},13.87,"http://selleckchem.com/products/quinidine-sulfate.html","C20H24N2O2.1/2H2SO4.H2O","hemisulfate hydrate","Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium","O.O.COC1=CC2=C(C=C1)N=CC=C2C(O)C3CC4CCN3CC4C=C.COC5=CC6=C(C=C5)N=CC=C6C(O)C7CC8CCN7CC8C=C.O[S](O)(=O)=O",4.446,4,2,8]
["S3897","(-)-Arctigenin","g7","L7100-06","in 10mM DMSO","Influenza Virus","Microbiology","(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.",372.41,"7770-78-7",{"v":74,"d":"74.00"},198.71,"N/A","N/A","http://selleckchem.com/products/neg-rotation-arctigenin.html","C21H24O6","free base","N/A","COC1=C(O)C=CC(=C1)CC2C(COC2=O)CC3=CC=C(OC)C(=C3)OC",3.743,5,1,7]
["S3898","Hydroxy Camptothecine","h7","L7100-06","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.",364.35,"64439-81-2",{"v":29,"d":"29.00"},79.59,"N/A","N/A","http://selleckchem.com/products/hydroxy-camptothecine.html","C20H16N2O5","free base","10-Hydroxycamptothecin, Hydroxycamptothecine","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=C(C=CC(=C5)O)N=C34)C2=O",1.504,4,1,1]
["S3984","Nordihydroguaiaretic acid (NDGA)","a8","L7100-06","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase","Metabolism","Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.",302.36,"500-38-9",{"v":60,"d":"60.00"},198.44,"<1","N/A","http://selleckchem.com/products/nordihydroguaiaretic-acid.html","C18H22O4","free base","N/A","CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O",4.708,0,4,5]
["S3988","Theophylline-7-acetic acid","b8","L7100-06","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Theophylline-7-acetic acid (Acefylline, acetyloxytheophylline, Carboxymethyltheophylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class.",{"v":238.2,"d":"238.20"},"652-37-9",{"v":47,"d":"47.00"},197.31,"N/A","N/A","http://selleckchem.com/products/theophylline-7-acetic.html","C9H10N4O4","free base","Acefylline, acetyloxytheophylline, Carboxymethyltheophylline","CN1C(=O)N(C)C2=C([N](CC(O)=O)C=N2)C1=O",-0.619,4,0,2]
["S4001","Cabozantinib malate","c8","L7100-06","in 10mM DMSO","Apoptosis related,Axl,c-Kit,c-Met,c-RET,FLT3,VEGFR","Protein Tyrosine Kinase","Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis.",635.59,"1140909-48-3",{"v":100,"d":"100.00"},157.33,"<1","N/A","http://selleckchem.com/products/cabozantinib-malate.html","C28H24FN3O5.C4H6O5","Malate","XL184","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3.OC(CC(O)=O)C(O)=O",3.331,8,3,11]
["S4007","Pentamidine isethionate","d8","L7100-06","in 10mM DMSO","phosphatase","Metabolism","Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.",592.68,"140-64-7",{"v":100,"d":"100.00"},168.73,{"v":100,"d":"100.00"},168.73,"http://selleckchem.com/products/pentamidine-isethionate.html","C19H24N4O2.2C2H6O4S","isethionate","N/A","NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1.OCC[S](O)(=O)=O.OCC[S](O)(=O)=O",0.751,2,4,14]
["S4011","Ampiroxicam","e8","L7100-06","in 10mM DMSO","COX","Neuronal Signaling","Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.",447.46,"99464-64-9",{"v":90,"d":"90.00"},201.14,"<1","N/A","http://selleckchem.com/products/ampiroxicam.html","C20H21N3O7S","free base","CP 65703","CCOC(=O)OC(C)OC1=C(N(C)[S](=O)(=O)C2=C1C=CC=C2)C(=O)NC3=NC=CC=C3",1.718,8,1,8]
["S4019","Avanafil","f8","L7100-06","in 10mM DMSO","PDE","Metabolism","Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.",483.95,"330784-47-9",{"v":97,"d":"97.00"},200.43,"<1","N/A","http://selleckchem.com/products/avanafil.html","C23H26ClN7O3","free base","N/A","COC1=C(Cl)C=C(CNC2=C(C=NC(=N2)N3CCCC3CO)C(=O)NCC4=NC=CC=N4)C=C1",2.165,6,3,9]
["S4034","Diphemanil Methylsulfate","g8","L7100-06","in 10mM DMSO","AChR","Neuronal Signaling","Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).",389.51,"62-97-5",{"v":25,"d":"25.00"},64.18,{"v":28,"d":"28.00"},71.89,"http://selleckchem.com/products/diphemanil-methylsulfate.html","C20H24N.CH3O4S","Methylsulfate","N/A","CO[S]([O-])(=O)=O.C[N+]1(C)CC[C](CC1)=[C](C2=CC=CC=C2)C3=CC=CC=C3",0.038,1,0,3]
["S4040","Norethindrone","h8","L7100-06","in 10mM DMSO","Others,0","Others","Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.",298.42,"68-22-4",{"v":60,"d":"60.00"},201.06,"<1","N/A","http://selleckchem.com/products/norethindrone-norethisterone.html","C20H26O2","free base","Norethisterone","CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.315,1,0,0]
["S4042","Nafcillin Sodium","a9","L7100-06","in 10mM DMSO","β-lactamase","Microbiology","Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.",454.47,"7177-50-6",{"v":91,"d":"91.00"},200.23,{"v":91,"d":"91.00"},200.23,"http://selleckchem.com/products/nafcillin-sodium.html","C21H21N2O5S.H2O.Na","sodium Salt","CL 8491","O.CCOC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C(=O)O[Na])C4=C(C=CC=C4)C=C1",2.213,5,1,6]
["S4045","Pheniramine Maleate","b9","L7100-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.",356.42,"132-20-7",{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},"http://selleckchem.com/products/pheniramine-maleate.html","C16H20N2.C4H4O4","Maleate","N/A","CN(C)CCC(C1=CC=CC=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",0.036,3,0,7]
["S4046","Estradiol Cypionate","c9","L7100-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.",396.56,"313-06-4",{"v":79,"d":"79.00"},199.21,"<1","N/A","http://selleckchem.com/products/estradiol-cypionate.html","C26H36O3","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2OC(=O)CCC5CCCC5",6.589,2,1,5]
["S4047","Bisacodyl","d9","L7100-06","in 10mM DMSO","Others","Others","Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.",361.39,"603-50-9",{"v":72,"d":"72.00"},199.23,"<1","N/A","http://selleckchem.com/products/bisacodyl.html","C22H19NO4","free base","N/A","CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(OC(C)=O)C=C2)C3=CC=CC=N3",3.691,5,0,7]
["S4075","Zinc Pyrithione","e9","L7100-06","in 10mM DMSO","Fungal,Proton Pump","Transmembrane Transporters","Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.",{"v":317.7,"d":"317.70"},"13463-41-7",{"v":30,"d":"30.00"},94.43,"<1","N/A","http://selleckchem.com/products/zinc-pyrithione.html","C10H8N2O2S2Zn","free base","OM-1563","O1N2C=CC=CC2=[SH][Zn]13ON4C=CC=CC4=[SH]3",0.874,2,0,0]
["S4078","Mefenamic Acid","f9","L7100-06","in 10mM DMSO","COX","Neuronal Signaling","Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.",241.29,"61-68-7",{"v":48,"d":"48.00"},198.93,"<1","N/A","http://selleckchem.com/products/mefenamic-acid.html","C15H15NO2","free base","CI 473, CN-35355","CC1=C(C)C(=CC=C1)NC2=CC=CC=C2C(O)=O",3.982,1,1,3]
["S4080","Triamterene","g9","L7100-06","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.",253.26,"396-01-0",{"v":20,"d":"20.00"},78.97,"<1","N/A","http://selleckchem.com/products/triamterene.html","C12H11N7","free base","SKF8542","NC1=NC2=C(N=C(C3=CC=CC=C3)C(=N2)N)C(=N1)N",1.017,4,3,1]
["S4088","Flumethasone","h9","L7100-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.",410.45,"2135-17-3",{"v":82,"d":"82.00"},199.78,"<1","N/A","http://selleckchem.com/products/flumethasone.html","C22H28F2O5","free base","RS-2177, NSC-54702,Flumetasone","CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.546,2,2,2]
["S4089","Halobetasol Propionate","a10","L7100-06","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.",484.96,"66852-54-8",{"v":97,"d":"97.00"},200.02,"<1","N/A","http://selleckchem.com/products/halobetasol-propionate.html","C25H31ClF2O5","free base","BMY-30056, CGP-14458,Ulobetasol propionate","CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.797,4,1,5]
["S4095","Difluprednate","b10","L7100-06","in 10mM DMSO","Others","Others","Difluprednate (difluoroprednisolone butyrate acetate, DFBA, CM 9155) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications.",508.55,"23674-86-4",{"v":100,"d":"100.00"},196.64,"<1","N/A","http://selleckchem.com/products/difluprednate.html","C27H34F2O7","free base","CM 9155","CCCC(=O)OC1(CCC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)COC(C)=O",3.108,6,1,8]
["S4098","Halcinonide","c10","L7100-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.",454.96,"3093-35-4",{"v":90,"d":"90.00"},197.82,"<1","N/A","http://selleckchem.com/products/halcinonide.html","C24H32ClFO5","free base","SQ-18566","CC1(C)OC2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CCl",2.384,4,1,2]
["S4102","Eprosartan Mesylate","d10","L7100-06","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Eprosartan(SKF-108566J) is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.",520.62,"144143-96-4",{"v":104,"d":"104.00"},199.76,"<1","N/A","http://selleckchem.com/products/eprosartan-mesylate.html","C23H24N2O4S.CH4O3S","Mesylate","SKF-108566J","CCCCC1=NC=C(\\C=C(CC2=CC=CS2)\\C(O)=O)[N]1CC3=CC=C(C=C3)C(O)=O.C[S](O)(=O)=O",4.418,3,0,10]
["S4107","Clofazimine","e10","L7100-06","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dyes,Phospholipase (e.g. PLA)","Metabolism","Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.",{"v":473.4,"d":"473.40"},"2030-63-9",{"v":5,"d":"5.00"},10.56,"<1","N/A","http://selleckchem.com/products/clofazimine.html","C27H22Cl2N4","free base","NSC-141046","CC(C)N=C1C=C2N(C3=CC=C(Cl)C=C3)C4=C(C=CC=C4)N=C2C=C1NC5=CC=C(Cl)C=C5",7.137,2,1,4]
["S4110","Estradiol Benzoate","f10","L7100-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol benzoate(β-Estradiol 3-benzoate) is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.",376.49,"50-50-0",{"v":75,"d":"75.00"},199.21,"<1","N/A","http://selleckchem.com/products/estradiol-benzoate.html","C25H28O3","free base","β-Estradiol 3-benzoate","CC12CCC3C(CCC4=CC(=CC=C34)OC(=O)C5=CC=CC=C5)C1CCC2O",5.512,2,1,3]
["S4114","Triclabendazole","g10","L7100-06","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.",359.66,"68786-66-3",{"v":72,"d":"72.00"},200.19,"<1","N/A","http://selleckchem.com/products/triclabendazole.html","C14H9Cl3N2OS","free base","CGA-89317,tcbz","CSC1=NC2=C([NH]1)C=C(Cl)C(=C2)OC3=C(Cl)C(=CC=C3)Cl",5.982,2,1,3]
["S4120","Sulconazole Nitrate","h10","L7100-06","in 10mM DMSO","Fungal","Microbiology","Sulconazole Nitrate(Exelderm,RS 44872) is an imidazole derivative with broad-spectrum antifungal activity.",460.76,"61318-91-0",{"v":92,"d":"92.00"},199.67,"<1","N/A","http://selleckchem.com/products/sulconazole-nitrate.html","C18H15Cl3N2S.HNO3","Nitrate","Exelderm,RS 44872","O[N+]([O-])=O.ClC1=CC=C(CSC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C=C1",4.467,1,0,6]
["S4147","Azithromycin Dihydrate","a11","L7100-06","in 10mM DMSO","Anti-infection","Microbiology","Azithromycin Dihydrate(CP-62993 dihydrate) is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.",785.02,"117772-70-0",{"v":100,"d":"100.00"},127.39,{"v":10,"d":"10.00"},12.74,"http://selleckchem.com/products/azithromycin-dihydrate.html","C38H72N2O12.2H2O","free base","CP-62993 dihydrate","O.O.CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",1.663,7,3,7]
["S4149","Amfenac Sodium Monohydrate","b11","L7100-06","in 10mM DMSO","COX","Neuronal Signaling","Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.",295.27,"61618-27-7",{"v":59,"d":"59.00"},199.82,{"v":59,"d":"59.00"},199.82,"http://selleckchem.com/products/amfenac-sodium-monohydrate.html","C15H12NO3.H2O.Na","free base","N/A","O.[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=CC=C2",{"v":0.47,"d":"0.470"},1,1,4]
["S4151","Penfluridol","c11","L7100-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.",523.97,"26864-56-2",{"v":100,"d":"100.00"},190.85,"<1","N/A","http://selleckchem.com/products/penfluridol.html","C28H27ClF5NO","free base","TLP-607,R-16341","OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(=C(Cl)C=C4)C(F)(F)F",7.311,0,0,8]
["S4162","Benzethonium Chloride","d11","L7100-06","in 10mM DMSO","AChR","Neuronal Signaling","Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.",448.08,"121-54-0",{"v":90,"d":"90.00"},200.86,{"v":90,"d":"90.00"},200.86,"http://selleckchem.com/products/benzethonium-chloride.html","C27H42NO2.Cl","Chloride","N/A","[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1",2.147,2,0,12]
["S4165","Benzydamine HCl","e11","L7100-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.",345.87,"132-69-4",{"v":69,"d":"69.00"},{"v":199.5,"d":"199.50"},{"v":69,"d":"69.00"},{"v":199.5,"d":"199.50"},"http://selleckchem.com/products/benzydamine-hcl.html","C19H23N3O.HCl","Hydrochloride","AF864","Cl.CN(C)CCCOC1=N[N](CC2=CC=CC=C2)C3=CC=CC=C13",4.368,2,0,7]
["S4166","Chlorpropamide","f11","L7100-06","in 10mM DMSO","ATPase","Transmembrane Transporters","Chlorpropamide inhibits Na(+),K(+)-ATPase and stimulates a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane. Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.",276.74,"94-20-2",{"v":55,"d":"55.00"},198.74,"<1","N/A","http://selleckchem.com/products/chlorpropamide.html","C10H13ClN2O3S","free base","N/A","CCCNC(=O)N[S](=O)(=O)C1=CC=C(Cl)C=C1",2.058,3,2,4]
["S4167","Cyromazine","g11","L7100-06","in 10mM DMSO","Parasite","Microbiology","Cyromazine(Cyromazin,CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide.",166.18,"66215-27-8",{"v":33,"d":"33.00"},198.58,{"v":1,"d":"1.00"},6.02,"http://selleckchem.com/products/cyromazine.html","C6H10N6","free base","Cyromazin,CGA-72662","NC1=NC(=NC(=N1)N)NC2CC2",0.313,3,3,2]
["S4169","Teriflunomide","h11","L7100-06","in 10mM DMSO","Dehydrogenase,Immunology & Inflammation related","Metabolism","Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.",270.21,"163451-81-8",{"v":32,"d":"32.00"},118.43,"<1","N/A","http://selleckchem.com/products/teriflunomide.html","C12H9F3N2O2","free base","A77 1726, HMR-1726","C/C(O)=C(C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F",2.091,1,2,3]
["S4172","Cetylpyridinium Chloride","a2","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","Cetylpyridinium chloride(CPC) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.",339.99,"123-03-5",{"v":68,"d":"68.00"},200.01,{"v":68,"d":"68.00"},200.01,"http://selleckchem.com/products/cetylpyridinium-chloride.html","C21H38N.Cl","Chloride","CPC","[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1",5.563,0,0,15]
["S4186","Domiphen Bromide","b2","L7100-07","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Domiphen bromide (NSC-39415) is a quaternary ammonium antiseptic with actions as a cationic surfactant.",414.46,"538-71-6",{"v":83,"d":"83.00"},200.26,{"v":83,"d":"83.00"},200.26,"http://selleckchem.com/products/domiphen-bromide.html","C22H40NO.Br","free base","NSC-39415","[Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1",3.157,1,0,15]
["S4192","Chlorquinaldol","c2","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","Chlorquinaldol(Chloquinan) is an antimicrobial agent used for local antisepsy.",228.07,"72-80-0",{"v":46,"d":"46.00"},201.69,"<1","N/A","http://selleckchem.com/products/chlorquinaldol.html","C10H7Cl2NO","free base","Chloquinan","CC1=CC=C2C(=CC(=C(O)C2=N1)Cl)Cl",3.385,1,1,0]
["S4195","Broxyquinoline","d2","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","Broxyquinoline(Dibromohydroxyquinoline) is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.",302.95,"521-74-4",{"v":17,"d":"17.00"},56.11,"<1","N/A","http://selleckchem.com/products/broxyquinoline.html","C9H5Br2NO","free base","Dibromohydroxyquinoline","OC1=C2N=CC=CC2=C(Br)C=C1Br",3.271,1,1,0]
["S4196","Ethacridine lactate monohydrate","e2","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","Ethacridine lactate monohydrate(Acrinol monohydrat) is an aromatic organic compound based on acridine used as an antiseptic agent.",361.39,"6402-23-9",{"v":72,"d":"72.00"},199.23,{"v":5,"d":"5.00"},13.84,"http://selleckchem.com/products/ethacridine-lactate-monohydrate.html","C15H15N3O.C3H6O3.H2O","Lactate","Acrinol monohydrat","O.CCOC1=CC2=C(N)C3=CC=C(N)C=C3N=C2C=C1.CC(O)C(O)=O",1.592,3,3,3]
["S4201","Florfenicol","f2","L7100-07","in 10mM DMSO","Bacterial","Microbiology","Florfenicol (SCH-25298,(-)-Florfenicol) is a fluorinated synthetic analog of thiamphenicol with broad-spectrum, primarily bacteriostatic activity.",358.21,"73231-34-2",{"v":72,"d":"72.00"},{"v":201,"d":"201.00"},"<1","N/A","http://selleckchem.com/products/florfenicol.html","C12H14Cl2FNO4S","free base","SCH-25298,(-)-Florfenicol","C[S](=O)(=O)C1=CC=C(C=C1)C(O)C(CF)NC(=O)C(Cl)Cl",1.597,3,2,6]
["S4208","Chromocarb","g2","L7100-07","in 10mM DMSO","Others","Others","Chromocarb(Atremon) is a vasoprotectant.",190.15,"4940-39-0",{"v":38,"d":"38.00"},199.84,"<1","N/A","http://selleckchem.com/products/chromocarb.html","C10H6O4","free base","Atremon","OC(=O)C1=CC(=O)C2=CC=CC=C2O1",1.247,3,0,1]
["S4213","Dirithromycin","h2","L7100-07","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Dirithromycin (LY-237216, ASE 136,Dynabac) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.",835.07,"62013-04-1",{"v":11,"d":"11.00"},13.17,"<1","N/A","http://selleckchem.com/products/dirithromycin.html","C42H78N2O14","free base","LY-237216, ASE 136,Dynabac","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C4NC(COCCOC)OC(C4C)C1(C)O",1.869,10,3,12]
["S4216","Valnemulin HCl","a3","L7100-07","in 10mM DMSO","Bacterial","Microbiology","Valnemulin HCl is a broad-spectrum bacteriostatic agent inhibiting protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.",601.28,"133868-46-9",{"v":100,"d":"100.00"},166.31,{"v":100,"d":"100.00"},166.31,"http://selleckchem.com/products/valnemulin-hcl.html","C31H52N2O5S.HCl","Hydrochloride","N/A","Cl.CC(C)C(N)C(=O)NCC(C)(C)SCC(=O)OC1CC(C)(C=C)C(O)C(C)C23CCC(C)C1(C)C2C(=O)CC3",4.048,4,3,10]
["S4223","Mevastatin","b3","L7100-07","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.",390.51,"73573-88-3",{"v":78,"d":"78.00"},199.74,"<1","N/A","http://selleckchem.com/products/mevastatin.html","C23H34O5","free base","ML-236B,Compactin","CCC(C)C(=O)OC1CCC=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",3.966,4,1,7]
["S4224","Erythritol","c3","L7100-07","in 10mM DMSO","Others","Others","Erythritol(meso-Erythritol) is a sugar alcohol used as low-calorie sweetener.",122.12,"149-32-6",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/erythritol.html","C4H10O4","free base","meso-Erythritol","OCC(O)C(O)CO",-1.919,0,4,3]
["S4225","Mexiletine HCl","d3","L7100-07","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Mexiletine HCl (KO1173,Mexitil) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.",215.72,"5370-01-4",{"v":43,"d":"43.00"},199.33,{"v":43,"d":"43.00"},199.33,"http://selleckchem.com/products/mexiletine-hcl.html","C11H17NO.HCl","Hydrochloride","KO1173,Mexitil","Cl.CC(N)COC1=C(C)C=CC=C1C",2.716,1,1,3]
["S4231","Pilocarpine HCl","e3","L7100-07","in 10mM DMSO","AChR","Neuronal Signaling","Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.",244.72,"54-71-7",{"v":48,"d":"48.00"},196.14,{"v":48,"d":"48.00"},196.14,"http://selleckchem.com/products/pilocarpine-hcl.html","C11H16N2O2.HCl","Hydrochloride","NSC 5746 HCl","Cl.CCC1C(COC1=O)CC2=CN=C[N]2C",1.347,3,0,3]
["S4232","Nithiamide","f3","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.",187.18,"140-40-9",{"v":37,"d":"37.00"},197.67,"<1","N/A","http://selleckchem.com/products/nithiamide.html","C5H5N3O3S","free base","CL 5279","CC(=O)NC1=NC=C(S1)[N+]([O-])=O",-0.034,2,1,2]
["S4237","Primaquine Diphosphate","g3","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.",455.34,"63-45-6",{"v":91,"d":"91.00"},199.85,{"v":91,"d":"91.00"},199.85,"http://selleckchem.com/products/primaquine-diphosphate.html","C15H21N3O.2H3O4P","Diphosphate","N/A","COC1=CC(=C2N=CC=CC2=C1)NC(C)CCCN.O[P](O)(O)=O.O[P](O)(O)=O",1.062,2,2,6]
["S4243","Deoxycorticosterone acetate","h3","L7100-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.",{"v":372.5,"d":"372.50"},"56-47-3",{"v":11,"d":"11.00"},29.53,"<1","N/A","http://selleckchem.com/products/deoxycorticosterone-acetate.html","C23H32O4","free base","11-Deoxycorticosterone acetate, DOC acetate, Cortexone acetate","CC(=O)OCC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",3.567,4,0,4]
["S4253","Epinastine HCl","a4","L7100-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Epinastine (WAL-801CL) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.",285.77,"108929-04-0",{"v":57,"d":"57.00"},199.46,{"v":57,"d":"57.00"},199.46,"http://selleckchem.com/products/epinastine-hcl.html","C16H15N3.HCl","Hydrochloride","WAL-801CL HCl","Cl.NC1=NCC2N1C3=CC=CC=C3CC4=CC=CC=C24",3.164,1,1,0]
["S4260","Tamibarotene","b4","L7100-07","in 10mM DMSO","Retinoid Receptor","Metabolism","Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.",351.44,"94497-51-5",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://selleckchem.com/products/tamibarotene.html","C22H25NO3","free base","Am 80","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S4268","Flufenamic acid","c4","L7100-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.",281.23,"530-78-9",{"v":56,"d":"56.00"},199.13,"<1","N/A","http://selleckchem.com/products/flufenamic-acid.html","C14H10F3NO2","free base","N/A","OC(=O)C1=CC=CC=C1NC2=CC=CC(=C2)C(F)(F)F",3.952,1,1,4]
["S4269","Vinorelbine ditartrate (KW-2307)","d4","L7100-07","in 10mM DMSO","Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.",1079.11,"125317-39-7",{"v":100,"d":"100.00"},92.67,{"v":100,"d":"100.00"},92.67,"http://selleckchem.com/products/vinorelbine-tartrate.html","C45H54N4O8.2C4H6O6","ditartrate","Nor-5'-anhydrovinblastine ditartrate,KW-2307","CCC1=CC2CN(C1)CC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC.OC(C(O)C(O)=O)C(O)=O.OC(C(O)C(O)=O)C(O)=O",{"v":-4,"d":"-4.000"},11,5,16]
["S4270","Oxiracetam","e4","L7100-07","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Oxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.",158.16,"62613-82-5",{"v":31,"d":"31.00"},{"v":196,"d":"196.00"},{"v":31,"d":"31.00"},{"v":196,"d":"196.00"},"http://selleckchem.com/products/oxiracetam.html","C6H10N2O3","free base","ISF 2522","NC(=O)CN1CC(O)CC1=O",-2.143,2,2,2]
["S4288","Chloroambucil","f4","L7100-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.",304.21,"305-03-3",{"v":60,"d":"60.00"},197.23,"<1","N/A","http://selleckchem.com/products/chloroambucil.html","C14H19Cl2NO2","free base","Chlorambucil,CB-1348,WR-139013","OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl",3.899,1,0,9]
["S4303","9-Aminoacridine","g4","L7100-07","in 10mM DMSO","Anti-infection","Microbiology","9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.",194.23,"90-45-9",{"v":38,"d":"38.00"},195.64,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/9-aminoacridine.html","C13H10N2","free base","Aminacrine","NC1=C2C=CC=CC2=NC3=CC=CC=C13",2.606,1,1,0]
["S4316","Clopamide","h4","L7100-07","in 10mM DMSO","Others","Others","Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.",345.84,"636-54-4",{"v":69,"d":"69.00"},199.51,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/clopamide.html","C14H20ClN3O3S","Free Base","N/A","CC1CCCC(C)N1NC(=O)C2=CC=C(Cl)C(=C2)[S](N)(=O)=O",1.793,3,2,3]
["S4330","Isoetharine Mesylate","a5","L7100-07","in 10mM DMSO","Others","Others","Isoetharine is a selective beta2-adrenergic receptor agonist, which gives quick relief for bronchospasm and asthma.",335.42,"7279-75-6",{"v":67,"d":"67.00"},199.75,{"v":67,"d":"67.00"},199.75,"http://www.selleckchem.com/products/isoetharine-mesylate.html","C14H25NO6S","mesylate","N/A","CCC(NC(C)C)C(O)C1=CC=C(O)C(=C1)O.C[S](O)(=O)=O",1.586,0,4,5]
["S4334","Mesoridazine Besylate","b5","L7100-07","in 10mM DMSO","Others","Others","N/A",544.75,"32672-69-8",{"v":100,"d":"100.00"},183.57,{"v":100,"d":"100.00"},183.57,"http://www.selleckchem.com/products/mesoridazine-besylate.html","C27H32N2O4S3","besylate","N/A","CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)[S](C)=O.O[S](=O)(=O)C5=CC=CC=C5",5.614,1,0,5]
["S4336","Metaraminol Bitartrate","c5","L7100-07","in 10mM DMSO","Others","Others","N/A",317.29,"33402-03-8",{"v":63,"d":"63.00"},198.56,{"v":63,"d":"63.00"},198.56,"http://www.selleckchem.com/products/metaraminol-bitartrate.html","C13H19NO8","bitartrate","Metaradrine Bitartrate","CC(N)C(O)C1=CC=CC(=C1)O.OC(C(O)C(O)=O)C(O)=O",-3.582,2,5,5]
["S4344","Oxprenolol HCl","d5","L7100-07","in 10mM DMSO","Adrenergic Receptor","Others","Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity.",301.81,"6452-73-9",{"v":60,"d":"60.00"},{"v":198.8,"d":"198.80"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/oxprenolol-hcl.html","C15H23NO3.HCl","hydrochloride","N/A","Cl.CC(C)NCC(O)COC1=CC=CC=C1OCC=C",2.614,2,2,9]
["S4353","Terfenadine","e5","L7100-07","in 10mM DMSO","Calcium Channel,Caspase,Histamine Receptor,NCX,Potassium Channel","Transmembrane Transporters","Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.  Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.",471.67,"50679-08-8",{"v":94,"d":"94.00"},199.29,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/terfenadine.html","C32H41NO2","Free Base","N/A","CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",6.498,0,1,9]
["S4354","Thiostrepton","f5","L7100-07","in 10mM DMSO","Others","Others","Thiostrepton (Alaninamide, Bryamycin, Thiactin) is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes.",1664.89,"1393-48-2",{"v":100,"d":"100.00"},60.06,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/thiostrepton.html","C72H85N19O18S5","Free Base","Alaninamide, Bryamycin, Thiactin","CCC(C)C1NC2C=CC3=C(C=C(N=C3C2O)C(=O)OC(C)C4NC(=O)C5=CSC(=N5)C(NC(=O)C6CSC(=N6)\\C(NC(=O)C(NC(=O)C7=CSC(=N7)C8(CCC(=NC8C9=CSC4=N9)C%10=NC(=CS%10)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)=C\\C)C(C)(O)C(C)O)C(C)O",-1.361,20,16,12]
["S4367","Suxibuzone","g5","L7100-07","in 10mM DMSO","Others","Others","Suxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone, and is commonly used in horses.",438.47,"27470-51-5",{"v":88,"d":"88.00"},{"v":200.7,"d":"200.70"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/suxibuzone.html","C24H26N2O6","Free Base","N/A","CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3",3.504,5,0,11]
["S4373","Dicyclomine HCl","h5","L7100-07","in 10mM DMSO","Others","Others","Dicyclomine is an anticholinergic drug, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle).",345.95,"67-92-5",{"v":22,"d":"22.00"},63.59,{"v":69,"d":"69.00"},199.45,"http://www.selleckchem.com/products/dicyclomine-hcl.html","C19H36ClNO2","Hydrochloride","Dicycloverine HCl","Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2",5.487,2,0,8]
["S4387","Bendroflumethiazide","a6","L7100-07","in 10mM DMSO","Others","Others","N/A",421.41,"73-48-3",{"v":85,"d":"85.00"},{"v":201.7,"d":"201.70"},"N/A","N/A","http://selleckchem.com/products/bendroflumethiazide.html","C15H14F3N3O4S2","sulfonamide","Bendrofluazide","N[S](=O)(=O)C1=CC2=C(NC(CC3=CC=CC=C3)N[S]2(=O)=O)C=C1C(F)(F)F","N/A","N/A","N/A","N/A"]
["S4394","Clofoctol","b6","L7100-07","in 10mM DMSO","Others","Others","N/A",365.34,"37693-01-9",{"v":73,"d":"73.00"},199.81,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/clofoctol.html","C21H26Cl2O","Free Base","N/A","CC(C)(C)CC(C)(C)C1=CC(=C(O)C=C1)CC2=CC=C(Cl)C=C2Cl",7.662,0,1,5]
["S4396","Digoxigenin","c6","L7100-07","in 10mM DMSO","Others","Others","N/A",390.51,"1672-46-4",{"v":78,"d":"78.00"},199.74,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/digoxigenin.html","C23H34O5","Free Base","Lanadigigenin","CC12CCC(O)CC1CCC3C2CC(O)C4(C)C(CCC34O)C5=CC(=O)OC5",2.276,2,2,1]
["S4406","Pindolol","d6","L7100-07","in 10mM DMSO","5-HT Receptor","Others","N/A",248.32,"13523-86-9",{"v":50,"d":"50.00"},201.35,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/pindolol.html","C14H20N2O2","Free Base","N/A","CC(C)NCC(O)COC1=C2C=C[NH]C2=CC=C1",1.925,1,3,6]
["S4502","Eltrombopag","e6","L7100-07","in 10mM DMSO","TpoR","Immunology & Inflammation","Eltrombopag (SB-497115), a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP).",442.47,"496775-61-2",{"v":26,"d":"26.00"},58.76,"<1","N/A","http://selleckchem.com/products/eltrombopag.html","C25H22N4O4","Free Base","SB-497115","CC1=CC=C(C=C1C)N2N=C(C)C(=N/NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(O)=O)/C2=O",4.702,4,2,5]
["S4505","Vinblastine (NSC-49842) sulfate","f6","L7100-07","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1","N/A","http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4506","Acetazolamide","g6","L7100-07","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).",222.25,"59-66-5",{"v":44,"d":"44.00"},197.98,"<1","N/A","http://selleckchem.com/products/acetazolamide.html","C4H6N4O3S2","free base","Diamox","CC(=O)NC1=NN=C(S1)[S](N)(=O)=O",-1.329,5,2,2]
["S4546","Xylitol","h6","L7100-07","in 10mM DMSO","Autophagy","Autophagy","Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.",152.15,"87-99-0",{"v":30,"d":"30.00"},197.17,{"v":30,"d":"30.00"},197.17,"http://selleckchem.com/products/xylitol.html","C5H12O5","free base","Adonitol, Ribitol, Xylite, D-Xylitol, Adonite","OCC(O)C(O)C(O)CO",{"v":-2.43,"d":"-2.430"},0,5,4]
["S4571","Hexylresorcinol","a7","L7100-07","in 10mM DMSO","Tyrosinase","Proteases","Hexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.",194.27,"136-77-6",{"v":38,"d":"38.00"},{"v":195.6,"d":"195.60"},"<1","N/A","http://selleckchem.com/products/hexylresorcinol.html","C12H18O2","free base","4-Hexylresorcinol","CCCCCCC1=C(O)C=C(O)C=C1",4.113,0,2,5]
["S4576","Sulfabenzamide","b7","L7100-07","in 10mM DMSO","Bacterial","Microbiology","Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.",276.31,"127-71-9",{"v":55,"d":"55.00"},199.05,"<1","N/A","http://selleckchem.com/products/sulfabenzamide.html","C13H12N2O3S","free base","Sultrin, N-Sulfanilylbenzamide","NC1=CC=C(C=C1)[S](=O)(=O)NC(=O)C2=CC=CC=C2",1.442,3,2,3]
["S4578","Tyloxapol","c7","L7100-07","in 10mM DMSO","Others","Others","Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.","N/A","25301-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/tyloxapol.html","(C14H22O.C2H4O.CH2O)x","free base","Triton WR1339","CC1=CC(=CC(=C1OCCO)CC2=C(OCCO)C(=CC(=C2)C(C)(C)CC(C)(C)C)CC3=C(OCCO)C=CC(=C3)C(C)(C)CC(C)(C)C)C(C)(C)CC(C)(C)C",{"v":16.58,"d":"16.580"},3,3,22]
["S4583","Butamben","d7","L7100-07","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.",193.24,"94-25-7",{"v":38,"d":"38.00"},196.65,{"v":38,"d":"38.00"},196.65,"http://selleckchem.com/products/butamben.html","C11H15NO2","free base","Butyl 4-aminobenzoate","CCCCOC(=O)C1=CC=C(N)C=C1",2.267,2,1,5]
["S4610","Mebendazole","e7","L7100-07","in 10mM DMSO","Parasite","Microbiology","Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.",295.29,"31431-39-7",{"v":6,"d":"6.00"},20.32,"<1","N/A","http://selleckchem.com/products/mebendazole.html","C16H13N3O3","free base","Vermox, Telmin, Pantelmin, Mebenvet","COC(=O)NC1=NC2=C([NH]1)C=CC(=C2)C(=O)C3=CC=CC=C3",3.055,4,2,4]
["S4635","Cyproheptadine hydrochloride sesquihydrate","f7","L7100-07","in 10mM DMSO","5-HT Receptor,SETD","Neuronal Signaling","Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.",350.88,"41354-29-4",{"v":70,"d":"70.00"},{"v":199.5,"d":"199.50"},"<1","N/A","https://www.selleckchem.com/products/cyproheptadine-hydrochloride-sesquihydrate.html","C21H21N.HCl.3/2H2O","hydrochloride sesquihydrate","Periactin hydrochloride, Peritol","O.O.O.Cl.Cl.CN1CCC(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C24.CN5CCC(CC5)=C6C7=CC=CC=C7C=CC8=CC=CC=C68",5.478,0,0,0]
["S4641","Tedizolid Phosphate","g7","L7100-07","in 10mM DMSO","Antibiotics","Microbiology","Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.",450.32,"856867-55-5",{"v":22,"d":"22.00"},48.85,"<1","N/A","http://selleckchem.com/products/tedizolid-phosphate.html","C17H16FN6O6P","free base","TR-701FA","C[N]1N=NC(=N1)C2=NC=C(C=C2)C3=CC=C(C=C3F)N4CC(CO[P](O)(O)=O)OC4=O",1.712,7,0,6]
["S4646","Ciclesonide","h7","L7100-07","in 10mM DMSO","COVID-19,Glucocorticoid Receptor","Endocrinology & Hormones","Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.",540.69,"126544-47-6",{"v":100,"d":"100.00"},184.95,"<1","N/A","http://selleckchem.com/products/ciclesonide.html","C32H44O7","free base","Alvesco, Omnaris, RPR251526, Zetonna","CC(C)C(=O)OCC(=O)C12OC(OC1CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC23C)C6CCCCC6",4.696,6,1,6]
["S4650","Atipamezole","a8","L7100-07","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.",212.29,"104054-27-5",{"v":42,"d":"42.00"},197.84,"<1","N/A","http://selleckchem.com/products/atipamezole.html","C14H16N2","Free Base","MPV-1248, MPV1248, MPV 1248, Antisedan","CCC1(CC2=C(C1)C=CC=C2)C3=CN=C[NH]3",3.012,1,1,2]
["S4667","Lidocaine hydrochloride","b8","L7100-07","in 10mM DMSO","EGFR","Angiogenesis","Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.",{"v":270.8,"d":"270.80"},"73-78-9",{"v":54,"d":"54.00"},199.41,{"v":54,"d":"54.00"},199.41,"http://selleckchem.com/products/lidocaine-hydrochloride.html","C14H22N2O.HCl","hydrochloride","Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural","Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",3.008,1,1,5]
["S4669","Benzocaine hydrochloride","c8","L7100-07","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.",201.65,"23239-88-5",{"v":40,"d":"40.00"},198.36,"<1","N/A","http://selleckchem.com/products/benzocaine-hydrochloride.html","C9H11NO2.HCl","hydrochloride","Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride","Cl.CCOC(=O)C1=CC=C(N)C=C1",1.669,2,1,3]
["S4697","Saxagliptin hydrate","d8","L7100-07","in 10mM DMSO","DPP","Proteases","Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",333.43,"945667-22-1",{"v":66,"d":"66.00"},197.94,{"v":1,"d":"1.00"},{"v":3,"d":"3.00"},"http://selleckchem.com/products/saxagliptin-hydrate.html","C18H25N3O2.H2O","hydrate","BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate","O.NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.068,1,1,2]
["S4708","Palmitoylethanolamide","e8","L7100-07","in 10mM DMSO","PPAR","Metabolism","Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.",299.49,"544-31-0",{"v":59,"d":"59.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/palmitoylethanolamide.html","C18H37NO2","free base","Palmidrol|N-palmitoylethanolamine","CCCCCCCCCCCCCCCC(=O)NCCO",5.431,1,2,16]
["S4709","Latanoprost","f8","L7100-07","in 10mM DMSO","GPR,Immunology & Inflammation related,RAR/RXR","Immunology & Inflammation","Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.",432.59,"130209-82-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/latanoprost.html","C26H40O5","Free Base","Xalatan, PhXA41, PHXA-41","CC(C)OC(=O)CCC\\C=C/CC1C(O)CC(O)C1CCC(O)CCC2=CC=CC=C2",4.365,2,3,14]
["S4727","Cinnarizine","g8","L7100-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.",368.51,"298-57-7",{"v":73,"d":"73.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/cinnarizine.html","C26H28N2","free base","Stugeron, Dimitronal, Stutgin, Cinarizine","C1CN(CCN1C\\C=C\\C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4",5.524,0,0,6]
["S4735","Salvianolic acid B","h8","L7100-07","in 10mM DMSO","Sirtuin","Epigenetics","Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.",718.61,"121521-90-2",{"v":100,"d":"100.00"},139.16,{"v":100,"d":"100.00"},139.16,"http://selleckchem.com/products/salvianolic-acid-b.html","C36H30O16","free base","Sal B, Lithospermate B, Lithospermic acid B","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=CC=C(O)C3=C2C(C(O3)C4=CC=C(O)C(=C4)O)C(=O)OC(CC5=CC=C(O)C(=C5)O)C(O)=O",4.718,7,7,14]
["S4736","Trapidil","a9","L7100-07","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Trapidil (Rocornal, Trapymin, Avantrin, Trapymine) is a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells.",205.26,"15421-84-8",{"v":41,"d":"41.00"},199.75,{"v":41,"d":"41.00"},199.75,"http://selleckchem.com/products/trapidil.html","C10H15N5","free base","Rocornal, Trapymin, Avantrin, Trapymine","CCN(CC)C1=CC(=NC2=NC=N[N]12)C",1.922,3,0,3]
["S4817","Atenolol","b9","L7100-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.",266.34,"29122-68-7",{"v":53,"d":"53.00"},198.99,{"v":35,"d":"35.00"},131.41,"http://selleckchem.com/products/atenolol.html","C14H22N2O3","free base","Tenormin, Normiten, Blokium","CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1",0.669,2,3,8]
["S4836","Nilutamide","c9","L7100-07","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.",317.22,"63612-50-0",{"v":63,"d":"63.00"},{"v":198.6,"d":"198.60"},"<1","N/A","http://selleckchem.com/products/nilutamide.html","C12H10F3N3O4","Nonsteroidal antiandrogens","RU23908","CC1(C)NC(=O)N(C2=CC=C(C(=C2)C(F)(F)F)[N+]([O-])=O)C1=O",2.254,2,1,3]
["S4849","Levocetirizine Dihydrochloride","d9","L7100-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.",461.81,"130018-87-0",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/levocetirizine-dihydrochloride.html","C21H25ClN2O3.2HCl","dihydrochloride","Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S4856","Iproniazid","e9","L7100-07","in 10mM DMSO","MAO","Metabolism","Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.",179.22,"54-92-2",{"v":35,"d":"35.00"},195.29,{"v":35,"d":"35.00"},195.29,"http://selleckchem.com/products/Iproniazid.html","C9H13N3O","free base","Marsilid, Iprazid","CC(C)NNC(=O)C1=CC=NC=C1",0.121,2,2,3]
["S4900","Tenovin-6","f9","L7100-07","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.",454.63,"1011557-82-6",{"v":98,"d":"98.00"},215.56,{"v":98,"d":"98.00"},215.56,"http://selleckchem.com/products/tenovin-6.html","C25H34N4O2S","free base","N/A","Cl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",{"v":5.7,"d":"5.700"},2,3,11]
["S4902","QNZ (EVP4593)","g9","L7100-07","in 10mM DMSO","NF-κB,TNF-alpha","NF-κB","QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.",356.42,"545380-34-5",{"v":5,"d":"5.00"},14.03,"<1","N/A","http://selleckchem.com/products/qnz-evp4593.html","C22H20N4O","free base","N/A","NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1",4.454,3,2,6]
["S4904","JZL184","h9","L7100-07","in 10mM DMSO","Lipase","Metabolism","JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.",520.49,"1101854-58-3",{"v":100,"d":"100.00"},192.13,"<1","N/A","http://selleckchem.com/products/jzl184.html","C27H24N2O9","free base","N/A","OC(C1CCN(CC1)C(=O)OC2=CC=C(C=C2)[N+]([O-])=O)(C3=CC=C4OCOC4=C3)C5=CC=C6OCOC6=C5",4.292,6,0,6]
["S4908","SN-38","a10","L7100-07","in 10mM DMSO","ADC Cytotoxin,Autophagy,Topoisomerase","DNA Damage/DNA Repair","SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.",{"v":392.4,"d":"392.40"},"86639-52-3",{"v":21,"d":"21.00"},53.52,"<1","N/A","http://selleckchem.com/products/sn-38.html","C22H20N2O5","free base","NK012","CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=C1C=C(O)C=C5)C(O)(CC)C(=O)OC4",2.446,4,1,2]
["S4921","MNS (3,4-Methylenedioxy-β-nitrostyrene)","b10","L7100-07","in 10mM DMSO","p97,Src,Syk,Tyrosinase","Ubiquitin","MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.",193.16,"1485-00-3",{"v":39,"d":"39.00"},201.91,"<1","N/A","http://selleckchem.com/products/mdbn.html","C9H7NO4","free base","MDBN","[O-][N+](=O)/C=C/C1=CC2=C(OCO2)C=C1",1.578,2,0,2]
["S4957","Linalool","c10","L7100-07","in 10mM DMSO","NMDAR","Neuronal Signaling","Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.",154.25,"78-70-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/linalool.html","C10H18O","free base","Phantol","CC(C)=CCCC(C)(O)C=C",2.735,0,0,4]
["S4977","Efonidipine","d10","L7100-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.",631.66,"111011-63-3",{"v":100,"d":"100.00"},158.31,"N/A","N/A","http://selleckchem.com/products/efonidipine.html","C34H38N3O7P","free base","NZ-105","CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",4.956,4,1,11]
["S4997","4-Butylresorcinol","e10","L7100-07","in 10mM DMSO","Tyrosinase","Proteases","4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.",166.22,"18979-61-8",{"v":34,"d":"34.00"},204.55,{"v":-1,"d":"-1.00"},-6.02,"https://www.selleckchem.com/products/4-butylresorcinol.html","C10H14O2","Resorcinol","4-n-Butylresorcinol, Rucinol","CCCCC1=CC=C(O)C=C1O",{"v":3.2,"d":"3.200"},0,2,3]
["S5006","Teprenone","f10","L7100-07","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Teprenone, an acylic polyisoprenoid, that is known as tetraprenylacetone or geranylgeranylacetone, is an anti-ulcer drug, clinically used for gastritis.  Teprenone(Geranylgeranylacetone) is an inducer of heat shock proteins (HSPs) expression.",330.55,"6809-52-5",{"v":66,"d":"66.00"},199.67,"N/A","N/A","http://selleckchem.com/products/teprenone.html","C23H38O","Isoprenoids","Geranylgeranylacetone, Tetraprenylacetone","CC(C)=CCC/C(C)=C/CC\\C(C)=C\\CC\\C(C)=C\\CCC(C)=O",7.413,1,0,12]
["S5012","Octenidine Dihydrochloride","g10","L7100-07","in 10mM DMSO","Bacterial","Microbiology","Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.",623.83,"70775-75-6",{"v":60,"d":"60.00"},96.18,"N/A","N/A","http://selleckchem.com/products/octenidine-ihydrochloride.html","C36H62N4.2HCl","Dihydrochloride","N/A","Cl.Cl.CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1",{"v":10.56,"d":"10.560"},2,0,25]
["S5029","Etofylline","h10","L7100-07","in 10mM DMSO","Others","Others","Etofylline (Aethophyllinum, Cordalin, Oxyphylline) is a N-7 substituted theophylline derivative used as a bronchodilator.",224.22,"519-37-9",{"v":44,"d":"44.00"},196.24,{"v":44,"d":"44.00"},196.24,"http://selleckchem.com/products/etofylline.html","C9H12N4O3","Methylxanthines","Aethophyllinum, Cordalin, Oxyphylline","CN1C(=O)N(C)C2=C([N](CCO)C=N2)C1=O",{"v":-0.64,"d":"-0.640"},3,1,2]
["S5032","Mephenesin","a11","L7100-07","in 10mM DMSO","NMDAR","Neuronal Signaling","Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.",182.22,"59-47-2",{"v":36,"d":"36.00"},197.56,{"v":30,"d":"30.00"},164.64,"http://selleckchem.com/products/mephenesin.html","C10H14O3","free base","Decontractyl, Cresoxydiol, Memphenesin, Mephedan","CC1=C(OCC(O)CO)C=CC=C1",1.249,1,2,4]
["S5033","Terconazole","b11","L7100-07","in 10mM DMSO","Fungal","Microbiology","Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470) is a new, broad-spectrum, triazole antifungal agent which is primarily used to treat vaginal fungal infections.",532.46,"67915-31-5",{"v":49,"d":"49.00"},92.03,"<1","N/A","http://selleckchem.com/products/terconazole.html","C26H31Cl2N5O3","free base","Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470","CC(C)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=NC=N4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",4.949,5,0,8]
["S5049","Thiocolchicoside","c11","L7100-07","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.",563.62,"602-41-5",{"v":100,"d":"100.00"},177.42,{"v":100,"d":"100.00"},177.42,"http://selleckchem.com/products/thiocolchicoside.html","C27H33NO10S","Phenolic glycosides","Thiocolchicine 2-glucoside analog, Coltramyl","COC1=C(OC)C2=C(CCC(NC(C)=O)C3=CC(=O)C(=CC=C23)SC)C=C1OC4OC(CO)C(O)C(O)C4O",0.446,6,5,7]
["S5062","Daclatasvir Dihydrochloride","d11","L7100-07","in 10mM DMSO","HCV Protease","Microbiology","Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection.",{"v":811.8,"d":"811.80"},"1009119-65-6",{"v":100,"d":"100.00"},123.18,{"v":100,"d":"100.00"},123.18,"https://www.selleckchem.com/products/daclatasvir-dihydrochloride.html","C40H50N8O6.2HCl","dihydrochloride","N/A","Cl.Cl.COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C([NH]5)C6CCCN6C(=O)C(NC(=O)OC)C(C)C",5.812,8,4,13]
["S5069","Dabrafenib Mesylate","e11","L7100-07","in 10mM DMSO","Raf","MAPK","Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.8 nM, 3.2 nM and 5 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.",615.67,"1195768-06-9",{"v":100,"d":"100.00"},162.42,"<1","N/A","http://selleckchem.com/products/dabrafenib-mesylate.html","C23H20F3N5O2S2.CH4O3S","mesylate","GSK2118436 Mesylate","CC(C)(C)C1=NC(=C(S1)C2=CC=NC(=N2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F.C[S](O)(=O)=O",4.963,5,2,6]
["S5077","Regorafenib (BAY-734506) Monohydrate","f11","L7100-07","in 10mM DMSO","c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, Kit (c-Kit), RET (c-RET), RAF-1, B-RAF and B-RAF(V600E) respectively.",500.83,"1019206-88-2",{"v":100,"d":"100.00"},199.67,"N/A","N/A","http://selleckchem.com/products/regorafenib-monohydrate.html","C21H15ClF4N4O3.H2O","monohydrate","Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate","O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F",4.174,4,3,6]
["S5078","Osimertinib mesylate","g11","L7100-07","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.",595.71,"1421373-66-1",{"v":9,"d":"9.00"},15.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/osimertinib-mesylate.html","C29H37N7O5S","mesylate","AZD9291 mesylate","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C.C[S](O)(=O)=O",4.257,4,2,10]
["S5141","Pyrithioxin","h11","L7100-07","in 10mM DMSO","Others","Others","Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.",368.47,"1098-97-1",{"v":60,"d":"60.00"},162.84,"N/A","N/A","http://selleckchem.com/products/pyrithioxin.html","C16H20N2O4S2","free base","Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide","CC1=NC=C(CSSCC2=CN=C(C)C(=C2CO)O)C(=C1O)CO",{"v":0,"d":"0.000"},0,0,0]
["S5177","Naproxen","a2","L7100-08","in 10mM DMSO","COX","Immunology & Inflammation","Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.",230.26,"22204-53-1",{"v":46,"d":"46.00"},199.77,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/naproxen.html","C14H14O3","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(O)=O",2.849,2,0,3]
["S5200","Diaveridine","b2","L7100-08","in 10mM DMSO","DHFR","Metabolism","Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.",260.29,"5355-16-8",{"v":25,"d":"25.00"},96.05,"N/A","N/A","http://selleckchem.com/products/diaveridine.html","C13H16N4O2","free base","AI3-23935, CCRIS-3784","COC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1",1.559,4,2,4]
["S5205","Nilotinib hydrochloride","c2","L7100-08","in 10mM DMSO","Bcr-Abl","Angiogenesis","Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.",565.98,"923288-95-3",{"v":100,"d":"100.00"},176.69,{"v":-1,"d":"-1.00"},-1.77,"http://selleckchem.com/products/nilotinib-hydrochloride.html","C28H22F3N7O.HCl","hydrochloride","AMN-107 HCl","Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",5.466,5,2,7]
["S5210","Sulfamethazine Sodium Salt","d2","L7100-08","in 10mM DMSO","Anti-infection","Microbiology","Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.",300.31,"1981-58-4",{"v":60,"d":"60.00"},199.79,"N/A","N/A","http://selleckchem.com/products/sulfamethazine-sodium-salt.html","C12H13N4O2S.Na","sodium salt","Sulfadimethyldiazine Sodium Salt","CC1=CC(=NC(=N1)N([Na])[S](=O)(=O)C2=CC=C(N)C=C2)C",0.982,4,1,3]
["S5233","Fenretinide (NSC 374551)","e2","L7100-08","in 10mM DMSO","Retinoid Receptor","Metabolism","Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.",391.55,"65646-68-6",{"v":78,"d":"78.00"},199.21,"<1","N/A","http://selleckchem.com/products/fenretinide.html","C26H33NO2","free base","4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(=O)NC2=CC=C(O)C=C2)C(C)(C)CCC1",6.463,1,2,6]
["S5234","Nintedanib Ethanesulfonate Salt","f2","L7100-08","in 10mM DMSO","FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.",649.76,"656247-18-6",{"v":100,"d":"100.00"},{"v":153.9,"d":"153.90"},{"v":100,"d":"100.00"},{"v":153.9,"d":"153.90"},"http://selleckchem.com/products/nintedanib-ethanesulfonate-salt.html","C31H33N5O4.C2H6O3S","ethanesulfonate","Intedanib, BIBF 1120","CC[S](O)(=O)=O.COC(=O)C1=CC2=C(C=C1)C(/C(=O)N2)=C(NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(C)CC4)\\C5=CC=CC=C5",{"v":2.9,"d":"2.900"},4,2,9]
["S5240","Lenvatinib (E7080) Mesylate","g2","L7100-08","in 10mM DMSO","c-Kit,c-RET,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Lenvatinib Mesylate (E7080) is a synthetic, orally available tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet-derived growth factor receptor α (PDGFRα), stem cell factor receptor (Kit (c-Kit)), and rearranged during transfection (RET (c-RET)). Lenvatinib Mesylate has potential antineoplastic activity.",522.96,"857890-39-2",{"v":39,"d":"39.00"},74.58,{"v":-1,"d":"-1.00"},-1.91,"http://selleckchem.com/products/lenvatinib-mesylate.html","C21H19ClN4O4.CH4O3S","Mesylate","E7080 mesylate","COC1=C(C=C2C(=CC=NC2=C1)OC3=CC(=C(NC(=O)NC4CC4)C=C3)Cl)C(N)=O.C[S](O)(=O)=O",2.418,5,3,6]
["S5241","Lapatinib ditosylate monohydrate","h2","L7100-08","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate)is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.",943.48,"388082-78-8",{"v":100,"d":"100.00"},105.99,{"v":-1,"d":"-1.00"},-1.06,"https://www.selleckchem.com/products/lapatinib-ditosylate-monohydrate.html","C43H44ClFN4O11S3","ditosylate monohydrate","Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate","O.CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC5=C(C=C4)N=CN=C5NC6=CC(=C(OCC7=CC(=CC=C7)F)C=C6)Cl",9.132,6,2,13]
["S5242","Cediranib Maleate","a3","L7100-08","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Cediranib Maleate (AZD-2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.",566.58,"857036-77-2",{"v":100,"d":"100.00"},{"v":176.5,"d":"176.50"},"<1","N/A","http://selleckchem.com/products/cediranib-maleate.html","C25H27FN4O3.C4H4O4","maleate","AZD-2171 maleate","COC1=CC2=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)N=CN=C2C=C1OCCCN5CCCC5.OC(=O)\\C=C/C(O)=O",1.765,7,1,10]
["S5243","Ruxolitinib Phosphate","b3","L7100-08","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",404.36,"1092939-17-7",{"v":80,"d":"80.00"},197.84,{"v":29,"d":"29.00"},71.72,"http://selleckchem.com/products/ruxolitinib-phosphate.html","C17H18N6.H3O4P","phosphate","INCB018424, INC424","O[P](O)(O)=O.N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",2.412,3,1,4]
["S5247","Selamectin","c3","L7100-08","in 10mM DMSO","Parasite","Microbiology","Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a  wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.",769.96,"220119-17-5",{"v":100,"d":"100.00"},129.88,"N/A","N/A","https://www.selleckchem.com/products/selamectin.html","C43H63NO11","free base","UK-124114","COC1CC(OC(C)C1O)OC/2C(C)\\C=C\\C=C\\3COC4/C(=N/O)C(=CC(C(=O)OC5CC(C\\C=C2C)OC6(CCC(C)C(O6)C7CCCCC7)C5)C34O)C",5.315,9,1,4]
["S5254","Dasatinib hydrochloride","d3","L7100-08","in 10mM DMSO","Bcr-Abl,kit,Src","Angiogenesis","Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.",524.47,"854001-07-3",{"v":100,"d":"100.00"},190.67,{"v":11,"d":"11.00"},20.97,"https://www.selleckchem.com/products/dasatinib-hydrochloride.html","C22H27Cl2N7O2S","hydrochloride","BMS-354825 HCl","Cl.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.821,4,3,7]
["S5273","Canrenone","e3","L7100-08","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.",340.46,"976-71-6",{"v":68,"d":"68.00"},199.73,"N/A","N/A","http://selleckchem.com/products/canrenone.html","C22H28O3","free base","Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone","CC12CCC(=O)C=C1C=CC3C2CCC4(C)C3CCC45CCC(=O)O5",3.519,3,0,0]
["S5278","Tedizolid (TR-700)","f3","L7100-08","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Tedizolid(TR-700) is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.",370.34,"856866-72-3",{"v":10,"d":"10.00"},{"v":27,"d":"27.00"},{"v":-1,"d":"-1.00"},{"v":-2.7,"d":"-2.70"},"https://www.selleckchem.com/products/tedizolid.html","C17H15FN6O3","Oxazolidinone","N/A","C[N]1N=NC(=N1)C2=CC=C(C=N2)C3=C(F)C=C(C=C3)N4CC(CO)OC4=O",1.784,6,1,4]
["S5279","Fendiline hydrochloride","g3","L7100-08","in 10mM DMSO","Calcium Channel,Ras","Transmembrane Transporters","Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.",351.91,"13636-18-5",{"v":70,"d":"70.00"},198.91,"N/A","N/A","http://selleckchem.com/products/fendiline-hydrochloride.html","C23H25N.HCl","hydrochloride","N/A","Cl.CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3",5.772,0,1,7]
["S5285","RU58841","h3","L7100-08","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen.",369.34,"154992-24-2",{"v":73,"d":"73.00"},197.65,"<1","N/A","http://selleckchem.com/products/ru58841.html","C17H18F3N3O3","free base","PSK3841, HMR3841","CC1(C)N(CCCCO)C(=O)N(C1=O)C2=CC=C(C#N)C(=C2)C(F)(F)F",2.548,2,1,6]
["S5286","Ramatroban","a4","L7100-08","in 10mM DMSO","Prostaglandin Receptor","Metabolism","Ramatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells.",416.47,"116649-85-5",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/ramatroban.html","C21H21FN2O4S","free base","BAY u 3405","OC(=O)CC[N]1C2=C(CC(CC2)N[S](=O)(=O)C3=CC=C(F)C=C3)C4=CC=CC=C14",{"v":3.51,"d":"3.510"},3,1,6]
["S5297","Vidarabine monohydrate","b4","L7100-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.",285.26,"24356-66-9",{"v":57,"d":"57.00"},199.82,"N/A","N/A","http://selleckchem.com/products/vidarabine-monohydrate.html","C10H13N5O4.H2O","hydrate","Spongoadenosine monohydrate, Vira-A monohydrate","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-2.088,4,4,2]
["S5298","Amoxicillin trihydrate","c4","L7100-08","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.",419.45,"61336-70-7",{"v":30,"d":"30.00"},71.52,"N/A","N/A","http://selleckchem.com/products/amoxicillin-trihydrate.html","C16H19N3O5S.3H2O","trihydrate","Amoxil trihydrate, Amoxipen trihydrate, Moxaline trihydrate","O.O.O.CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O",-3.161,3,3,4]
["S5325","Nitisinone","d4","L7100-08","in 10mM DMSO","Others","Metabolism","Nitisinone (NTBC, Nitisone, SC0735) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.",329.23,"104206-65-7",{"v":65,"d":"65.00"},197.43,"<1","N/A","http://selleckchem.com/products/nitisinone.html","C14H10F3NO5","free base","NTBC, Nitisone, SC0735","[O-][N+](=O)C1=CC(=CC=C1C(=O)C2C(=O)CCCC2=O)C(F)(F)F",{"v":2.53,"d":"2.530"},3,0,4]
["S5341","Metroprolol succinate","e4","L7100-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.",652.82,"98418-47-4",{"v":100,"d":"100.00"},153.18,{"v":100,"d":"100.00"},153.18,"http://selleckchem.com/products/metroprolol-succinate.html","C34H56N2O10","succinate","Metoprolol succinate","COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC2=CC=C(OCC(O)CNC(C)C)C=C2.OC(=O)CCC(O)=O",-2.255,6,4,21]
["S5353","Cefpiramide sodium","f4","L7100-08","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefpiramide sodium (CPMS, SM-1652,wy-44635) is an anionic β-lactam antibiotic. It exhibits antibacterial activity against gram-positive and gram-negative bacteria, in particular, to Pseudomonas aeruginosa, which can result in achronic life-threatening infection in the lungs of cystic fibrosis patients.",634.62,"74849-93-7",{"v":100,"d":"100.00"},157.57,{"v":100,"d":"100.00"},157.57,"http://selleckchem.com/products/cefpiramide-sodium.html","C25H23N8NaO7S2","Cephalosporin","SM-1652, wy-44635","[Na+].C[N]1N=NN=C1SCC2=C(N3C(SC2)C(NC(=O)C(NC(=O)C4=C(O)C=C(C)N=C4)C5=CC=C(O)C=C5)C3=O)C([O-])=O",-1.425,7,4,9]
["S5365","Alogliptin","g4","L7100-08","in 10mM DMSO","DPP","Proteases","Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.",339.39,"850649-61-5",{"v":67,"d":"67.00"},197.41,{"v":18,"d":"18.00"},53.04,"http://selleckchem.com/products/alogliptin.html","C18H21N5O2","Dipeptidyl Peptidase-4","SYR 322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S5371","Ajmaline","h4","L7100-08","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.",326.43,"4360-12-7",{"v":65,"d":"65.00"},199.12,{"v":-1,"d":"-1.00"},-3.06,"https://www.selleckchem.com/products/ajmaline.html","C20H26N2O2","free base","Cardiorythmine, Tachmalin","CCC1C(O)N2C3CC1C4C(O)C5(CC24)C3N(C)C6=CC=CC=C56",1.932,0,2,1]
["S5387","D-Tagatose","a5","L7100-08","in 10mM DMSO","Others","Others","D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.",180.16,"87-81-0",{"v":36,"d":"36.00"},199.83,{"v":-1,"d":"-1.00"},-5.55,"https://www.selleckchem.com/products/d-tagatose.html","C6H12O6","free base","N/A","OCC(O)C(O)C(O)C(=O)CO",-2.874,1,5,5]
["S5392","Mepivacaine","b5","L7100-08","in 10mM DMSO","Others","Others","Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia.",246.35,"96-88-8",{"v":49,"d":"49.00"},198.91,{"v":-1,"d":"-1.00"},-4.06,"https://www.selleckchem.com/products/mepivacaine.html","C15H22N2O","free base","Carbocaine","CN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",2.981,1,1,2]
["S5416","Metyrapone","c5","L7100-08","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.",226.27,"54-36-4",{"v":46,"d":"46.00"},203.29,{"v":-1,"d":"-1.00"},-4.42,"https://www.selleckchem.com/products/metyrapone.html","C14H14N2O","free base","NSC-25265, SU-4885","CC(C)(C1=CC=CN=C1)C(=O)C2=CC=CN=C2",1.847,3,0,3]
["S5453","Hyperoside","d5","L7100-08","in 10mM DMSO","NF-κB","NF-κB","Hyperoside (Hyperin, Quercetin 3-galactoside), a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.Hyperoside can inhibit activation of the NF-κB signaling pathway.",464.38,"482-36-0",{"v":92,"d":"92.00"},198.11,{"v":1,"d":"1.00"},2.15,"http://selleckchem.com/products/hyperoside.html","C21H20O12","free base","Hyperin, Quercetin 3-galactoside","OCC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S5486","Fluorometholone","e5","L7100-08","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.",376.46,"426-13-1",{"v":75,"d":"75.00"},199.22,"<1","N/A","http://selleckchem.com/products/fluorometholone.html","C22H29FO4","free base","Oxylone","CC1CC2C3CCC(O)(C(C)=O)C3(C)CC(O)C2(F)C4(C)C=CC(=O)C=C14",2.312,2,1,1]
["S5491","Lomefloxacin","f5","L7100-08","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic used to treat bacterial infections.",351.35,"98079-51-7",{"v":7,"d":"7.00"},19.92,{"v":-1,"d":"-1.00"},-2.85,"https://www.selleckchem.com/products/lomefloxacin.html","C17H19F2N3O3","free base","SC47111A","CCN1C=C(C(O)=O)C(=O)C2=C1C(=C(N3CCNC(C)C3)C(=C2)F)F",-0.828,2,1,3]
["S5507","Trimebutine maleate","g5","L7100-08","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.",503.54,"34140-59-5",{"v":100,"d":"100.00"},198.59,{"v":-1,"d":"-1.00"},-1.99,"https://www.selleckchem.com/products/trimebutine-maleate.html","C26H33NO9","Maleate salt","3, 4, 5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester Maleate Salt;","CCC(COC(=O)C1=CC(=C(OC)C(=C1)OC)OC)(N(C)C)C2=CC=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":1.12,"d":"1.120"},7,0,12]
["S5538","Tropisetron","h5","L7100-08","in 10mM DMSO","5-HT Receptor,AChR","Neuronal Signaling","Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.",284.35,"89565-68-4",{"v":10,"d":"10.00"},35.17,{"v":56,"d":"56.00"},196.94,"http://selleckchem.com/products/tropisetron.html","C17H20N2O2","free base","ICS 205-930","CN1C2CCC1CC(C2)OC(=O)C3=C[NH]C4=C3C=CC=C4",2.608,2,1,3]
["S5542","7-Nitroindazole","a6","L7100-08","in 10mM DMSO","NOS","Immunology & Inflammation","7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.",163.13,"2942-42-9",{"v":32,"d":"32.00"},196.16,"N/A","N/A","https://www.selleckchem.com/products/7-nitroindazole.html","C7H5N3O2","free base","N/A","[O-][N+](=O)C1=CC=CC2=C1[NH]N=C2",1.368,1,1,1]
["S5554","Lanatoside C","b6","L7100-08","in 10mM DMSO","Akt,Antiviral,Apoptosis related,Autophagy,JAK,mTOR,PI3K,STAT,Wnt/beta-catenin","Immunology & Inflammation","Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.",985.12,"17575-22-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/lanatoside-c.html","C49H76O20","free base","N/A","CC1OC(CC(O)C1OC2CC(O)C(OC3CC(OC(C)=O)C(OC4OC(CO)C(O)C(O)C4O)C(C)O3)C(C)O2)OC5CCC6(C)C(CCC7C6CC(O)C8(C)C(CCC78O)C9=CC(=O)OC9)C5",0.631,12,7,12]
["S5564","Xylazine","c6","L7100-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.",220.33,"7361-61-7",{"v":44,"d":"44.00"},{"v":199.7,"d":"199.70"},{"v":-1,"d":"-1.00"},-4.54,"https://www.selleckchem.com/products/xylazine.html","C12H16N2S","free base","N/A","CC1=C(NC2=NCCCS2)C(=CC=C1)C",3.265,1,1,2]
["S5573","Tilmicosin phosphate","d6","L7100-08","in 10mM DMSO","Antibiotics","Microbiology","Tilmicosin phosphate is a macrolide antibiotic that is used to treat cattle for pathogens that cause Bovine Respiratory Disease.",967.13,"137330-13-3",{"v":100,"d":"100.00"},{"v":103.4,"d":"103.40"},"N/A","N/A","http://selleckchem.com/products/tilmicosin-phosphate.html","C46H80N2O13.H3O4P","phosphate","N/A","CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(O)C(C2O)N(C)C)C(CCN3CC(C)CC(C)C3)CC(C)C(=O)\\C=C\\C(=C\\C1COC4OC(C)C(O)C(OC)C4OC)C.O[P](O)(O)=O",3.392,9,4,12]
["S5582","Cytarabine hydrochloride","e6","L7100-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.",279.68,"69-74-9",{"v":55,"d":"55.00"},196.65,"N/A","N/A","http://selleckchem.com/products/cytarabine-hydrochloride.html","C9H13N3O5.HCl","hydrochloride","N/A","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.014,3,4,2]
["S5606","Sulfamide","f6","L7100-08","in 10mM DMSO","Others","Others","Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis.",96.11,"7803-58-9",{"v":100,"d":"100.00"},1040.49,{"v":-1,"d":"-1.00"},{"v":-10.4,"d":"-10.40"},"https://www.selleckchem.com/products/sulfamide.html","H4N2O2S","free base","Sulfuric diamide","N[S](N)(=O)=O",-1.863,2,2,0]
["S5609","Chicago Sky Blue 6B","g6","L7100-08","in 10mM DMSO","MIF","Immunology & Inflammation","Chicago Sky Blue 6B (Direct Blue 1, Pontamine sky blue) is a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. It is an inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 0.81 μM.",{"v":992.8,"d":"992.80"},"2610-05-1",{"v":20,"d":"20.00"},20.14,{"v":-1,"d":"-1.00"},-1.01,"https://www.selleckchem.com/products/chicago-sky-blue-6b.html","C34H24N6Na4O16S4","free base","Direct Blue 1, Pontamine sky blue","[Na+].[Na+].[Na+].[Na+].COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(O)C4=C(N)C(=CC(=C4C=C3)[S]([O-])(=O)=O)[S]([O-])(=O)=O)OC)N=NC5=C(O)C6=C(N)C(=CC(=C6C=C5)[S]([O-])(=O)=O)[S]([O-])(=O)=O",-3.754,6,4,11]
["S5625","Ammonium lactate","h6","L7100-08","in 10mM DMSO","Bacterial","Microbiology","Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties.",107.11,"515-98-0","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/ammonium-iactate.html","C3H9NO3","free base","Lac-hydrin","[NH4+].CC(O)C([O-])=O",-3.725,0,1,1]
["S5627","Amsacrine hydrochloride","a7","L7100-08","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.",429.92,"54301-15-4",{"v":85,"d":"85.00"},197.71,"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/amsacrine-hydrochloride.html","C21H20ClN3O3S","free base","m-AMSA, acridinyl anisidide","Cl.COC1=CC(=CC=C1NC2=C3C=CC=CC3=NC4=C2C=CC=C4)N[S](C)(=O)=O",{"v":4.18,"d":"4.180"},4,2,5]
["S5651","Dexrazoxane","b7","L7100-08","in 10mM DMSO","Others","Others","Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.",268.27,"24584-09-6",{"v":54,"d":"54.00"},201.29,"<1","N/A","http://selleckchem.com/products/dexrazoxane.html","C11H16N4O4","free base","ICRF-187","CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-2.104,4,2,3]
["S5662","Ranitidine","c7","L7100-08","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ranitidine(AH-19065) is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.",{"v":314.4,"d":"314.40"},"66357-35-5",{"v":63,"d":"63.00"},200.38,{"v":-1,"d":"-1.00"},-3.18,"https://www.selleckchem.com/products/ranitidine.html","C13H22N4O3S","free base","AH-19065","CNC(/NCCSCC1=CC=C(CN(C)C)O1)=C\\[N+]([O-])=O",1.039,1,2,10]
["S5669","Isoxsuprine hydrochloride","d7","L7100-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.",337.84,"579-56-6",{"v":68,"d":"68.00"},201.28,{"v":4,"d":"4.00"},11.84,"http://www.selleckchem.com/products/isoxsuprine-hydrochloride.html","C18H24ClNO3","hydrochloride","N/A","Cl.CC(COC1=CC=CC=C1)NC(C)C(O)C2=CC=C(O)C=C2",3.384,1,3,7]
["S5670","Chloropyramine hydrochloride","e7","L7100-08","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Chloropyramine hydrochloride (Halopyramine) is a histamine receptor H1 antagonist and has anti-cholinergic, antispasmodic, and antiallergic effects.",326.26,"6170-42-9",{"v":65,"d":"65.00"},199.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/chloropyramine-hydrochloride.html","C16H21Cl2N3","hydrochloride","Halopyramine hydrochloride","Cl.CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=CC=CC=N2",4.149,1,0,6]
["S5686","Tryptanthrin","f7","L7100-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.",248.24,"13220-57-0",{"v":8,"d":"8.00"},32.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tryptanthrin.html","C15H8N2O2","Free Base","N/A","O=C1N2C3=C(C=CC=C3)C(=O)C2=NC4=CC=CC=C14",2.331,3,0,0]
["S5709","Norgestrel","g7","L7100-08","in 10mM DMSO","ROS","Immunology & Inflammation","Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.",312.45,"6533-00-2",{"v":62,"d":"62.00"},198.43,"<1","N/A","http://selleckchem.com/products/norgestrel.html","C21H28O2","free base","WY-3707, SH-70850, SH-850, FH 122-A","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S5714","lurasidone","h7","L7100-08","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.",492.68,"367514-87-2",{"v":7,"d":"7.00"},14.21,"<1","N/A","http://selleckchem.com/products/lurasidone.html","C28H36N4O2S","free base","SM-13496","O=C1C2C3CCC(C3)C2C(=O)N1CC4CCCCC4CN5CCN(CC5)C6=NSC7=CC=CC=C67",4.896,3,0,5]
["S5715","Atorvastatin","a8","L7100-08","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.",558.64,"134523-00-5",{"v":100,"d":"100.00"},179.01,"<1","N/A","http://www.selleckchem.com/products/atorvastatin.html","C33H35FN2O5","Free Base","N/A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC(O)=O)C3=CC=C(F)C=C3)C4=CC=CC=C4",5.555,2,3,12]
["S5716","Abemaciclib (LY2835219)","b8","L7100-08","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.",506.59,"1231929-97-7",{"v":6,"d":"6.00"},11.84,"<1","N/A","http://selleckchem.com/products/abemaciclib.html","C27H32F2N8","free base","LY2835219","CCN1CCN(CC1)CC2=CN=C(NC3=NC=C(F)C(=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)C=C2",4.957,4,1,7]
["S5735","Midodrine","c8","L7100-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.",254.28,"42794-76-3",{"v":51,"d":"51.00"},200.57,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/midodrine.html","C12H18N2O4","Free Base","N/A","COC1=CC=C(OC)C(=C1)C(O)CNC(=O)CN",-0.548,3,3,6]
["S5754","Baricitinib phosphate","d8","L7100-08","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.",469.41,"1187595-84-1",{"v":94,"d":"94.00"},200.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/baricitinib-phosphate.html","C16H20N7O6PS","phosphate","INCB-028050 phosphate, LY-3009104 phosphate","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4.O[P](O)(O)=O",-0.108,5,1,5]
["S5780","Prazosin","e8","L7100-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.",{"v":383.4,"d":"383.40"},"19216-56-9",{"v":77,"d":"77.00"},200.83,{"v":1,"d":"1.00"},2.61,"http://www.selleckchem.com/products/prazosin.html","C19H21N5O4","Free Base","N/A","COC1=CC2=NC(=NC(=C2C=C1OC)N)N3CCN(CC3)C(=O)C4=CC=CO4",2.107,6,1,4]
["S5781","Raloxifene","f8","L7100-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.",473.58,"84449-90-1",{"v":95,"d":"95.00"},{"v":200.6,"d":"200.60"},{"v":1,"d":"1.00"},2.11,"http://www.selleckchem.com/products/raloxifene.html","C28H27NO4S","Free Base","Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129","OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.461,2,2,7]
["S5787","Dronedarone","g8","L7100-08","in 10mM DMSO","Adrenergic Receptor","Transmembrane Transporters","Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).",556.76,"141626-36-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/dronedarone.html","C31H44N2O5S","Free Base","SR33589","CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=C2C=C(N[S](C)(=O)=O)C=C3",7.015,5,1,18]
["S5793","Motesanib (AMG-706)","h8","L7100-08","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively.",373.45,"453562-69-1",{"v":75,"d":"75.00"},200.83,{"v":1,"d":"1.00"},2.68,"http://www.selleckchem.com/products/motesanib-amg-706.html","C22H23N5O","Free Base","N/A","CC1(C)CNC2=CC(=CC=C12)NC(=O)C3=C(NCC4=CC=NC=C4)N=CC=C3",2.721,3,3,5]
["S5796","Vanoxerine dihydrochloride","a9","L7100-08","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Vanoxerine (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex.",523.49,"67469-78-7",{"v":17,"d":"17.00"},32.47,{"v":5,"d":"5.00"},9.55,"http://www.selleck.cn/products/vanoxerine-dihydrochloride.html","C28H34Cl2F2N2O","dihydrochloride","GBR-12909","Cl.Cl.FC1=CC=C(C=C1)C(OCCN2CCN(CCCC3=CC=CC=C3)CC2)C4=CC=C(F)C=C4",6.878,1,0,10]
["S5806","Cilostamide","b9","L7100-08","in 10mM DMSO","PDE","Metabolism","Cilostamide (OPC 3689) is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively.",342.43,"68550-75-4",{"v":6,"d":"6.00"},17.52,"<1","N/A","http://www.selleckchem.com/products/cilostamide.html","C20H26N2O3","Free Base","OPC 3689","CN(C1CCCCC1)C(=O)CCCOC2=CC3=C(NC(=O)C=C3)C=C2",2.929,3,1,6]
["S5812","Choline Fenofibrate","c9","L7100-08","in 10mM DMSO","PPAR","Metabolism","Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.",421.91,"856676-23-8",{"v":5,"d":"5.00"},11.85,{"v":9,"d":"9.00"},21.33,"http://www.selleckchem.com/products/choline-fenofibrate.html","C22H28ClNO5","Free Base","ABT-335","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C([O-])=O.C[N+](C)(C)CCO",1.111,2,1,7]
["S5814","cariporide","d9","L7100-08","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.",283.35,"159138-80-4",{"v":87,"d":"87.00"},307.04,"<1","N/A","http://www.selleckchem.com/products/cariporide.html","C12H17N3O3S","Free Base","HOE-642","CC(C)C1=CC=C(C=C1[S](C)(=O)=O)C(=O)NC(N)=N",1.386,3,2,4]
["S5840","Palifosfamide","e9","L7100-08","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.",221.02,"31645-39-3",{"v":44,"d":"44.00"},199.08,{"v":13,"d":"13.00"},58.82,"http://www.selleckchem.com/products/palifosfamide.html","C4H11Cl2N2O2P","Free Base","ZIO-201, Isophosphamide mustard","O[P](=O)(NCCCl)NCCCl",0.018,1,2,6]
["S5863","Metronidazole Benzoate","f9","L7100-08","in 10mM DMSO","Bacterial","Microbiology","Metronidazole Benzoate (Benzoyl metronidazole) is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.",275.26,"13182-89-3",{"v":55,"d":"55.00"},199.81,{"v":1,"d":"1.00"},3.63,"http://www.selleckchem.com/products/metronidazole-benzoate.html","C13H13N3O4","Benzoate","Benzoyl metronidazole","CC1=NC=C([N]1CCOC(=O)C2=CC=CC=C2)[N+]([O-])=O",1.706,3,0,6]
["S5872","Estradiol dipropionate","g9","L7100-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a semisynthetic, steroidal estrogen which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders.",384.51,"113-38-2",{"v":21,"d":"21.00"},54.61,{"v":1,"d":"1.00"},{"v":2.6,"d":"2.60"},"https://www.selleckchem.com/products/estradiol-dipropionate.html","C24H32O4","Free Base","17-Beta-Estradiol-3,17-Dipropionate","CCC(=O)OC1CCC2C3CCC4=C(C=CC(=C4)OC(=O)CC)C3CCC12C",{"v":5.56,"d":"5.560"},4,0,6]
["S5885","Rabeprazole Related Compound E","h9","L7100-08","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of rabeprazole, which is a proton pump inhibitor.",343.44,"117977-21-6",{"v":69,"d":"69.00"},200.91,"<1","N/A","http://www.selleck.cn/products/rabeprazole-related-compound-e.html","C18H21N3O2S","Free Base","Rabeprazole thioether","COCCCOC1=C(C)C(=NC=C1)CSC2=NC3=C([NH]2)C=CC=C3",3.478,4,1,8]
["S5933","K 858","a10","L7100-08","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.",277.34,"72926-24-0",{"v":55,"d":"55.00"},198.31,{"v":1,"d":"1.00"},3.61,"http://www.selleckchem.com/products/k858.html","C13H15N3O2S","Free Base","N/A","CC(=O)NC1=NN(C(C)=O)C(C)(S1)C2=CC=CC=C2",1.535,3,1,2]
["S5939","Bendamustine (SDX105)","b10","L7100-08","in 10mM DMSO","Others","Others","Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.",358.26,"16506-27-7",{"v":72,"d":"72.00"},200.97,"<1","N/A","http://www.selleck.cn/products/bendamustine.html","C16H21Cl2N3O2","Free Base","SDX105","C[N]1C(=NC2=C1C=CC(=C2)N(CCCl)CCCl)CCCC(O)=O",3.606,2,0,9]
["S6005","VX-702","c10","L7100-08","in 10mM DMSO","p38 MAPK","MAPK","VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.",{"v":404.3,"d":"404.30"},"745833-23-2",{"v":81,"d":"81.00"},200.35,"<1","N/A","http://selleckchem.com/products/VX-702.html","C19H12F4N4O2","free base","N/A","NC(=O)N(C1=NC(=C(C=C1)C(N)=O)C2=C(F)C=C(F)C=C2)C3=C(F)C=CC=C3F",3.682,3,2,4]
["S6068","Doxycycline monohydrate","d10","L7100-08","in 10mM DMSO","Antibiotics","Microbiology","Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity.",462.45,"17086-28-1",{"v":47,"d":"47.00"},101.63,"N/A","N/A","http://www.selleck.cn/products/doxycycline-monohydrate.html","C22H26N2O9","monohydrate","N/A","O.CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",-0.959,3,5,2]
["S6249","Picolinic acid (PCL 016)","e10","L7100-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.",123.11,"98-98-6",24.62,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/picolinic-acid-pcl-016.html","C6H5NO2","free base","N/A","OC(=O)C1=NC=CC=C1",0.737,2,0,1]
["S6288","Chlorhexidine diacetate","f10","L7100-08","in 10mM DMSO","Anti-infection","Microbiology","Chlorhexidine diacetate (Hibitane diacetate) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.",625.55,"56-95-1",125.11,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/chlorhexidine-diacetate.html","C26H38Cl2N10O4","diacetate","Hibitane diacetate","CC(O)=O.CC(O)=O.ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1",3.964,2,6,17]
["S6409","Zucapsaicin","g10","L7100-08","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.",305.41,"25775-90-0",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://www.selleck.cn/products/zucapsaicin.html","C18H27NO3","Free Base","N/A","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C/C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S6411","Nimorazole","h10","L7100-08","in 10mM DMSO","Bacterial","Microbiology","Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity.",226.23,"6506-37-2",{"v":45,"d":"45.00"},198.91,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/nimorazole.html","C9H14N4O3","Free Base","N/A","[O-][N+](=O)C1=CN=C[N]1CCN2CCOCC2",-0.232,2,0,4]
["S6414","Apilimod (STA-5326)","a11","L7100-08","in 10mM DMSO","Interleukins,PIKfyve","PI3K/Akt/mTOR","Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.",418.49,"541550-19-0",{"v":84,"d":"84.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/apilimod.html","C23H26N6O2","Free Base","STA-5326","CC1=CC=CC(=C1)\\C=N\\NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4",4.485,6,1,8]
["S6438","Ufiprazole","b11","L7100-08","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.",329.42,"73590-85-9",{"v":66,"d":"66.00"},200.35,"<1","N/A","http://www.selleck.cn/products/ufiprazole.html","C17H19N3O2S","Free Base","Omeprazole sulfide","COC1=CC2=C([NH]C(=N2)SCC3=NC=C(C)C(=C3C)OC)C=C1",4.016,4,1,5]
["S6441","Riboflavin Tetrabutyrate","c11","L7100-08","in 10mM DMSO","Others","Others","Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.",656.72,"752-56-7",{"v":100,"d":"100.00"},152.27,"<1","N/A","http://www.selleck.cn/products/riboflavin-tetrabutyrate.html","C33H44N4O10","Tetrabutyrate","N/A","CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(CN1C2=C(C=C(C)C(=C2)C)N=C3C(=O)NC(=O)N=C13)OC(=O)CCC",5.754,12,1,21]
["S6455","Clebopride malate","d11","L7100-08","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting.",507.96,"57645-91-7",{"v":100,"d":"100.00"},196.87,{"v":33,"d":"33.00"},64.97,"http://www.selleck.cn/products/clebopride.html","C24H30ClN3O7","malate","N/A","COC1=C(C=C(Cl)C(=C1)N)C(=O)NC2CC[NH+](CC2)CC3=CC=CC=C3.OC(CC(O)=O)C([O-])=O",-1.413,3,3,8]
["S6484","uridine triacetate","e11","L7100-08","in 10mM DMSO","Others","Others","Uridine triacetate (Vistonuridine, PN401) is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity.",370.31,"4105-38-8",{"v":74,"d":"74.00"},199.83,{"v":7,"d":"7.00"},{"v":18.9,"d":"18.90"},"http://www.selleck.cn/products/uridine-triacetate.html","C15H18N2O9","triacetate","Vistonuridine, PN401","CC(=O)OCC1OC(C(OC(C)=O)C1OC(C)=O)N2C=CC(=O)NC2=O",-1.314,9,1,8]
["S6509","AG 494","f11","L7100-08","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).",280.28,"133550-35-3",{"v":56,"d":"56.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/ag-494.html","C16H12N2O3","free base","N/A","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NC2=CC=CC=C2",2.437,1,3,3]
["S6565","JK184","g11","L7100-08","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","JK184 inhibits Gli in the Hedgehog (Hh) pathway with IC50 of 30 nM in mammalian cells.",350.44,"315703-52-7",{"v":70,"d":"70.00"},199.75,"<1","N/A","http://www.selleck.cn/products/jk184.html","C19H18N4OS","free base","N/A","CCOC1=CC=C(NC2=NC(=CS2)C3=C(C)N=C4C=CC=C[N]34)C=C1",4.108,3,1,5]
["S6590","Hydrocortisone butyrate","h11","L7100-08","in 10mM DMSO","Others","Others","Hydrocortisone butyrate is a potent topical corticosteroid that can be used to treat a range of inflammatory skin conditions.",432.55,"13609-67-1",{"v":87,"d":"87.00"},201.13,"<1","N/A","http://www.selleck.cn/products/hydrocortisone-butyrate.html","C25H36O6","free base","N/A","CCCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C)C(=O)CO",2.785,4,2,6]
["S6601","(±)-Equol","a2","L7100-09","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.",242.27,"94105-90-5",{"v":48,"d":"48.00"},198.13,"<1","N/A","https://www.selleckchem.com/products/equol-1.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=C(C2)C=CC(=C3)O",3.211,1,2,1]
["S7007","Binimetinib (MEK162)","b2","L7100-09","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.",441.23,"606143-89-9",{"v":88,"d":"88.00"},199.44,"<1","N/A","http://selleckchem.com/products/mek162.html","C17H15BrF2N4O3","free base","ARRY-162,ARRY-438162","C[N]1C=NC2=C1C=C(C(=O)NOCCO)C(=C2F)NC3=C(F)C=C(Br)C=C3",2.775,3,3,6]
["S7009","LCL161","c2","L7100-09","in 10mM DMSO","IAP,Mitochondrial Metabolism","Apoptosis","LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).",500.63,"1005342-46-0",{"v":100,"d":"100.00"},199.75,"<1","N/A","http://selleckchem.com/products/lcl161.html","C26H33FN4O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(F)C=C4",3.785,4,2,8]
["S7010","GDC-0152","d2","L7100-09","in 10mM DMSO","IAP","Apoptosis","GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.",498.64,"873652-48-3",{"v":99,"d":"99.00"},198.54,{"v":3,"d":"3.00"},6.02,"http://selleckchem.com/products/gdc-0152.html","C25H34N6O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4",2.767,5,3,8]
["S7014","Merestinib (LY2801653)","e2","L7100-09","in 10mM DMSO","Axl,c-Met,DDR,FLT3,Mertk,ROS1","Protein Tyrosine Kinase","Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.",552.53,"1206799-15-6",{"v":100,"d":"100.00"},180.99,"<1","N/A","http://selleckchem.com/products/ly2801653-merestinib.html","C30H22F2N6O3","free base","N/A","C[N]1N=CC2=CC(=C(C=C12)C3=C[NH]N=C3)OC4=C(F)C=C(NC(=O)C5=CC=C(C)N(C5=O)C6=CC=C(F)C=C6)C=C4",{"v":4.5,"d":"4.500"},5,2,6]
["S7015","Birinapant (TL32711)","f2","L7100-09","in 10mM DMSO","Apoptosis related,HIV,IAP","Apoptosis","Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.",806.94,"1260251-31-7",{"v":100,"d":"100.00"},123.92,"<1","N/A","http://selleckchem.com/products/birinapant-tl32711.html","C42H56F2N8O6","free base","TL32711","CCC(NC(=O)C(C)NC)C(=O)N1CC(O)CC1CC2=C([NH]C3=C2C=CC(=C3)F)C4=C(CC5CC(O)CN5C(=O)C(CC)NC(=O)C(C)NC)C6=C([NH]4)C=C(F)C=C6",{"v":3.08,"d":"3.080"},4,8,15]
["S7016","VS-5584 (SB2343)","g2","L7100-09","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.",354.41,"1246560-33-7",{"v":71,"d":"71.00"},200.33,"<1","N/A","http://selleckchem.com/products/vs-5584-sb2343.html","C17H22N8O","free base","N/A","CC(C)[N]1C(=NC2=C1N=C(N=C2C3=CN=C(N)N=C3)N4CCOCC4)C",1.272,6,1,3]
["S7024","Stattic","h2","L7100-09","in 10mM DMSO","Apoptosis related,STAT","JAK/STAT","Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.",211.19,"19983-44-9",{"v":42,"d":"42.00"},198.87,"<1","N/A","http://selleckchem.com/products/stattic.html","C8H5NO4S","free base","N/A","[O-][N+](=O)C1=CC=C2C=C[S](=O)(=O)C2=C1",0.939,2,0,1]
["S7025","Embelin","a3","L7100-09","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,IAP","Apoptosis","Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.",294.39,"550-24-3",{"v":59,"d":"59.00"},200.41,"<1","N/A","http://selleckchem.com/products/embelin.html","C17H26O4","free base","Embelic Acid, NSC 91874","CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O",{"v":4.62,"d":"4.620"},2,2,10]
["S7029","AZD2461","b3","L7100-09","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.",395.43,"1174043-16-3",{"v":79,"d":"79.00"},199.78,"<1","N/A","http://selleckchem.com/products/azd2461.html","C22H22FN3O3","free base","N/A","COC1CCN(CC1)C(=O)C2=CC(=CC=C2F)CC3=NNC(=O)C4=CC=CC=C34",1.993,4,1,4]
["S7033","GSK2656157","c3","L7100-09","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.",416.45,"1337532-29-2",{"v":32,"d":"32.00"},76.84,"<1","N/A","http://selleckchem.com/products/gsk2656157.html","C23H21FN6O","free base","N/A","C[N]1C=C(C2=C(F)C3=C(C=C2)N(CC3)C(=O)CC4=CC=CC(=N4)C)C5=C(N)N=CN=C15",2.926,4,1,3]
["S7039","PD168393","d3","L7100-09","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.",369.22,"194423-15-9",{"v":73,"d":"73.00"},197.71,"<1","N/A","http://selleckchem.com/products/pd168393.html","C17H13BrN4O","free base","N/A","BrC1=CC(=CC=C1)NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23",4.043,3,2,4]
["S7046","Brefeldin A","e3","L7100-09","in 10mM DMSO","Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy","Transmembrane Transporters","Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.",280.36,"20350-15-6",{"v":4,"d":"4.00"},14.27,"<1","N/A","http://selleckchem.com/products/brefeldin-a.html","C16H24O4","free base","BFA, Cyanein, Decumbin","CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1",2.152,2,2,0]
["S7049","Oprozomib (ONX 0912)","f3","L7100-09","in 10mM DMSO","Proteasome","Proteases","Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.",532.61,"935888-69-0",{"v":100,"d":"100.00"},187.75,"<1","N/A","http://selleckchem.com/products/oprozomib-onx-0912.html","C25H32N4O7S","free base","PR-047","COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3",-0.202,8,3,14]
["S7050","AZ20","g3","L7100-09","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM in a cell-free assay, 8-fold selectivity over mTOR.",412.51,"1233339-22-4",{"v":83,"d":"83.00"},201.21,"<1","N/A","http://selleckchem.com/products/az20.html","C21H24N4O3S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=O)=O)C4=CC=CC5=C4C=C[NH]5",3.038,5,1,4]
["S7057","LY2874455","h3","L7100-09","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.",444.31,"1254473-64-7",{"v":88,"d":"88.00"},198.06,"<1","N/A","http://selleckchem.com/products/ly2874455.html","C21H19Cl2N5O2","free base","N/A","CC(OC1=CC=C2[NH]N=C(\\C=C\\C3=C[N](CCO)N=C3)C2=C1)C4=C(Cl)C=NC=C4Cl",4.121,4,2,7]
["S7059","Tezacaftor (VX-661)","a4","L7100-09","in 10mM DMSO","CFTR","Transmembrane Transporters","Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.",{"v":520.5,"d":"520.50"},"1152311-62-0",{"v":100,"d":"100.00"},192.12,"<1","N/A","http://selleckchem.com/products/vx-661.html","C26H27F3N2O6","free base","N/A","CC(C)(CO)C1=CC2=CC(=C(F)C=C2[N]1CC(O)CO)NC(=O)C3(CC3)C4=CC=C5OC(F)(F)OC5=C4",5.215,3,4,8]
["S7063","LY2090314","b4","L7100-09","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.",512.53,"603288-22-8",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/ly2090314.html","C28H25FN6O3","free base","N/A","FC1=CC2=C3[N](CCN(C2)C(=O)N4CCCCC4)C=C(C3=C1)C5=C(C(=O)NC5=O)C6=CN=C7C=CC=C[N]67",2.707,4,1,2]
["S7065","MK-8745","c4","L7100-09","in 10mM DMSO","Aurora Kinase","Cell Cycle","MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.",431.91,"885325-71-3",{"v":86,"d":"86.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-8745.html","C20H19ClFN5OS","free base","N/A","FC1=C(C=CC=C1Cl)C(=O)N2CCN(CC2)CC3=CC=CC(=N3)NC4=NC=CS4",3.805,3,1,5]
["S7070","GSK J4 HCl (GSKJ4 HCl)","d4","L7100-09","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.",453.96,"1797983-09-5",{"v":90,"d":"90.00"},198.26,{"v":90,"d":"90.00"},198.26,"http://selleckchem.com/products/gsk-j4-hcl.html","C24H27N5O2.HCl","Hydrochloride","N/A","Cl.CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",4.663,5,1,8]
["S7090","GSK923295","e4","L7100-09","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.",592.13,"1088965-37-0",{"v":100,"d":"100.00"},168.88,"<1","N/A","http://selleckchem.com/products/gsk923295.html","C32H38ClN5O4","free base","N/A","CC(C)OC1=CC=C(C=C1Cl)C(=O)NC(CNC(=O)CN(C)C)CC2=CC=C(C=C2)C3=C[N]4C=CC=C(C(C)O)C4=N3",4.004,4,3,12]
["S7094","PF-3758309","f4","L7100-09","in 10mM DMSO","Apoptosis related,PAK","Cytoskeletal Signaling","PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4  with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.",490.62,"898044-15-0",{"v":98,"d":"98.00"},199.75,"<1","N/A","http://selleckchem.com/products/pf-3758309.html","C25H30N8OS","free base","PF-03758309","CN(C)CC(NC(=O)N1CC2=C([NH]N=C2NC3=NC(=NC4=C3SC=C4)C)C1(C)C)C5=CC=CC=C5",4.077,4,3,6]
["S7096","KY02111","g4","L7100-09","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.",376.86,"1118807-13-8",{"v":75,"d":"75.00"},199.01,"<1","N/A","http://selleckchem.com/products/ky02111.html","C18H17ClN2O3S","free base","N/A","COC1=CC=C(CCC(=O)NC2=NC3=CC=C(Cl)C=C3S2)C=C1OC",4.362,4,1,6]
["S7099","(-)-Blebbistatin","h4","L7100-09","in 10mM DMSO","ATPase","Transmembrane Transporters","(-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.",292.33,"856925-71-8",{"v":58,"d":"58.00"},198.41,"<1","N/A","http://selleckchem.com/products/blebbistatin.html","C18H16N2O2","free base","(S)-(-)-Blebbistatin","CC1=CC=C2N=C3N(CCC3(O)C(=O)C2=C1)C4=CC=CC=C4",2.426,2,0,1]
["S7102","Berzosertib (VE-822)","a5","L7100-09","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.",463.55,"1232416-25-9",{"v":36,"d":"36.00"},77.66,"<1","N/A","http://selleckchem.com/products/ve-822.html","C24H25N5O3S","free base","VX970, M6620","CNCC1=CC=C(C=C1)C2=NOC(=C2)C3=C(N)N=CC(=N3)C4=CC=C(C=C4)[S](=O)(=O)C(C)C",3.697,6,2,7]
["S7103","Taselisib (GDC 0032)","b5","L7100-09","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Taselisib (GDC 0032, RG7604) is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.",460.53,"1282512-48-4",{"v":70,"d":"70.00"},{"v":152,"d":"152.00"},"<1","N/A","http://selleckchem.com/products/gdc-0032.html","C24H28N8O2","free base","RG7604","CC(C)[N]1N=C(C)N=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)C5=C[N](N=C5)C(C)(C)C(N)=O",{"v":2.47,"d":"2.470"},6,1,5]
["S7106","AZD3463","c5","L7100-09","in 10mM DMSO","ALK,Apoptosis related,Autophagy,IGF-1R","Protein Tyrosine Kinase","AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy.",448.95,"1356962-20-3",{"v":24,"d":"24.00"},53.46,"<1","N/A","http://selleckchem.com/products/azd3463.html","C24H25ClN6O","free base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)C3=C[NH]C4=C3C=CC=C4)C=CC(=C1)N5CCC(N)CC5",4.316,3,3,5]
["S7110","(+)-JQ1","d5","L7100-09","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1","N/A","http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7114","NU6027","e5","L7100-09","in 10mM DMSO","CDK","Cell Cycle","NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.",251.28,"220036-08-8",{"v":50,"d":"50.00"},198.98,"<1","N/A","http://selleckchem.com/products/nu6027.html","C11H17N5O2","free base","N/A","NC1=NC(=C(N=O)C(=N1)OCC2CCCCC2)N",2.576,4,2,4]
["S7122","XL888","f5","L7100-09","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1.",503.64,"1149705-71-4",{"v":100,"d":"100.00"},198.55,"<1","N/A","http://selleckchem.com/products/xl888.html","C29H37N5O3","free base","N/A","CCC(C)NC1=C(C=C(C)C(=C1)C(=O)NC2CC3CCC(C2)N3C4=NC=C(C=C4)C(=O)C5CC5)C(N)=O",3.772,4,3,9]
["S7124","SC144","g5","L7100-09","in 10mM DMSO","P-gp","Transmembrane Transporters","SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.",{"v":322.3,"d":"322.30"},"895158-95-9",{"v":28,"d":"28.00"},86.88,"<1","N/A","http://selleckchem.com/products/sc144.html","C16H11FN6O","free base","N/A","FC1=CC2=C(C=C1)[N]3C=CC=C3C(=N2)NNC(=O)C4=CN=CC=N4",1.819,4,2,3]
["S7125","KPT-185","h5","L7100-09","in 10mM DMSO","CRM1","Transmembrane Transporters","KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.",355.31,"1333151-73-7",{"v":71,"d":"71.00"},199.83,"<1","N/A","http://selleckchem.com/products/kpt-185.html","C16H16F3N3O3","free base","N/A","COC1=CC(=CC(=C1)C(F)(F)F)C2=N[N](\\C=C/C(=O)OC(C)C)C=N2",2.923,5,0,7]
["S7130","PR-619","a6","L7100-09","in 10mM DMSO","Autophagy,DUB","Ubiquitin","PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.",223.28,"2645-32-1",{"v":45,"d":"45.00"},201.54,"<1","N/A","http://selleckchem.com/products/pr-619.html","C7H5N5S2","free base","N/A","NC1=C(SC#N)C=C(SC#N)C(=N1)N",1.212,1,2,2]
["S7132","P5091 (P005091)","b6","L7100-09","in 10mM DMSO","DUB","Ubiquitin","P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.",348.22,"882257-11-6",{"v":28,"d":"28.00"},80.41,"<1","N/A","http://selleckchem.com/products/p5091-p005091.html","C12H7Cl2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=CC(=C2Cl)Cl)[N+]([O-])=O",4.989,1,0,4]
["S7133","P22077","c6","L7100-09","in 10mM DMSO","DUB","Ubiquitin","P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.",315.32,"1247819-59-5",{"v":63,"d":"63.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/p22077.html","C12H7F2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=C(F)C=C2F)[N+]([O-])=O",4.071,1,0,4]
["S7135","LDN-57444","d6","L7100-09","in 10mM DMSO","DUB","Proteases","LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.",397.64,"668467-91-2",{"v":11,"d":"11.00"},27.66,"<1","N/A","http://selleckchem.com/products/ldn-57444.html","C17H11Cl3N2O3","free base","N/A","CC(=O)O\\N=C/1C(=O)N(CC2=CC(=CC=C2Cl)Cl)C3=CC=C(Cl)C=C13",4.343,4,0,4]
["S7142","NSC697923","e6","L7100-09","in 10mM DMSO","E2 conjugating","Ubiquitin","NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.",267.26,"343351-67-7",{"v":53,"d":"53.00"},198.31,"<1","N/A","http://selleckchem.com/products/nsc697923.html","C11H9NO5S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(O2)[N+]([O-])=O",2.665,3,0,3]
["S7146","DMH1","f6","L7100-09","in 10mM DMSO","Autophagy,TGF-beta/Smad","TGF-beta/Smad","DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy.",380.44,"1206711-16-1",{"v":22,"d":"22.00"},57.83,"<1","N/A","http://selleckchem.com/products/dmh1.html","C24H20N4O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CC=NC5=C4C=CC=C5",4.036,4,0,4]
["S7147","LDN-212854","g6","L7100-09","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LDN-212854 (BMP Inhibitor III) is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.",406.48,"1432597-26-6",{"v":81,"d":"81.00"},199.27,"<1","N/A","http://selleckchem.com/products/ldn-212854.html","C25H22N6","free base","BMP Inhibitor III","C1CN(CCN1)C2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=CC6=C5C=CC=N6",2.909,3,1,3]
["S7149","NSC 319726","h6","L7100-09","in 10mM DMSO","p53","Apoptosis","NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.",234.32,"71555-25-4",{"v":19,"d":"19.00"},81.09,"<1","N/A","http://selleckchem.com/products/nsc319726.html","C11H14N4S","free base","N/A","CC(=N\\NC(=S)N1CCC1)/C2=NC=CC=C2",1.906,2,1,4]
["S7155","Batimastat (BB-94)","a7","L7100-09","in 10mM DMSO","MMP","Proteases","Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.",477.64,"130370-60-4",{"v":96,"d":"96.00"},200.99,"<1","N/A","http://selleckchem.com/products/bb-94.html","C23H31N3O4S2","free base","N/A","CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)C(CSC2=CC=CS2)C(=O)NO",3.218,3,3,12]
["S7156","Marimastat (BB-2516)","b7","L7100-09","in 10mM DMSO","MMP","Proteases","Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.",331.41,"154039-60-8",{"v":54,"d":"54.00"},162.94,"<1","N/A","http://selleckchem.com/products/marimastat.html","C15H29N3O5","free base","TA2516","CNC(=O)C(NC(=O)C(CC(C)C)C(O)C(=O)NO)C(C)(C)C",0.239,3,4,8]
["S7157","Ilomastat","c7","L7100-09","in 10mM DMSO","MMP","Proteases","Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.",388.46,"142880-36-2",{"v":78,"d":"78.00"},200.79,"<1","N/A","http://selleckchem.com/products/gm6001.html","C20H28N4O4","free base","GM6001, Galardin","CNC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CC(C)C)CC(=O)NO",1.624,3,4,9]
["S7173","Spebrutinib (CC-292)","d7","L7100-09","in 10mM DMSO","BTK","Angiogenesis","Spebrutinib (CC-292, AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.",423.44,"1202757-89-8",{"v":85,"d":"85.00"},200.74,"<1","N/A","http://selleckchem.com/products/avl-292.html","C22H22FN5O3","free base","AVL-292","COCCOC1=CC=C(NC2=NC=C(F)C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)C=C1",4.087,5,3,10]
["S7176","SKI II","e7","L7100-09","in 10mM DMSO","SPHK","Immunology & Inflammation","SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.",302.78,"312636-16-1",{"v":61,"d":"61.00"},201.47,"<1","N/A","http://selleckchem.com/products/ski-ii.html","C15H11ClN2OS","free base","SphK-I2","OC1=CC=C(NC2=NC(=CS2)C3=CC=C(Cl)C=C3)C=C1",4.746,1,2,3]
["S7189","Molibresib (I-BET-762)","f7","L7100-09","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.",{"v":423.9,"d":"423.90"},"1260907-17-2",{"v":84,"d":"84.00"},198.16,"<1","N/A","http://selleckchem.com/products/i-bet-762.html","C22H22ClN5O2","free base","GSK525762, GSK525762A","CCNC(=O)CC1N=C(C2=CC=C(Cl)C=C2)C3=CC(=CC=C3[N]4C(=NN=C14)C)OC",3.288,5,1,5]
["S7193","1-Azakenpaullone","g7","L7100-09","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","1-Azakenpaullone (1-Akp) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.",328.16,"676596-65-9",{"v":66,"d":"66.00"},201.12,"<1","N/A","http://selleckchem.com/products/1-azakenpaullone.html","C15H10BrN3O","free base","1-Akp","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3N=CC=C4)C=C1",2.949,2,2,0]
["S7194","Olverembatinib dimesylate (HQP1351)","h7","L7100-09","in 10mM DMSO","Bcr-Abl","Angiogenesis","Olverembatinib dimesylate (HQP1351, GZD824) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.",724.77,"1421783-64-3",{"v":100,"d":"100.00"},137.97,{"v":100,"d":"100.00"},137.97,"http://selleckchem.com/products/gzd824.html","C29H27F3N6O.2CH4O3S","Mesylate","GZD824 Dimesylate","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CC5=C([NH]N=C5)N=C4)C=C2)C(F)(F)F.C[S](O)(=O)=O.C[S](O)(=O)=O",4.047,3,2,7]
["S7195","RKI-1447","a8","L7100-09","in 10mM DMSO","ROCK","Cell Cycle","RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.",326.37,"1342278-01-6",{"v":65,"d":"65.00"},199.16,"<1","N/A","http://selleckchem.com/products/rki-1447.html","C16H14N4O2S","free base","N/A","OC1=CC(=CC=C1)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3",2.081,3,3,4]
["S7205","Idasanutlin (RG-7388)","b8","L7100-09","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7206","CNX-2006","c8","L7100-09","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.",545.53,"1375465-09-0",{"v":100,"d":"100.00"},183.31,"<1","N/A","http://selleckchem.com/products/cnx-2006.html","C26H27F4N7O2","free base","N/A","COC1=C(NC2=NC=C(C(=N2)NC3=CC=CC(=C3)NC(=O)C=C)C(F)(F)F)C=CC(=C1)NC4CN(CCF)C4",{"v":5.15,"d":"5.150"},4,4,12]
["S7207","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","d8","L7100-09","in 10mM DMSO","PKC","TGF-beta/Smad","Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.",553.65,"138489-18-6",{"v":100,"d":"100.00"},180.62,"<1","N/A","http://selleckchem.com/products/ro-31-8220-mesylate.html","C25H23N5O2S.CH4O3S","Mesylate","Bisindolylmaleimide IX Mesylate","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](CCCSC(N)=N)C5=CC=CC=C45.C[S](O)(=O)=O",3.452,2,2,7]
["S7209","GSK650394","e8","L7100-09","in 10mM DMSO","SGK","Metabolism","GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.",382.45,"890842-28-1",{"v":76,"d":"76.00"},198.72,"<1","N/A","http://selleckchem.com/products/gsk650394.html","C25H22N2O2","free base","N/A","OC(=O)C1=C(C=C(C=C1)C2=C[NH]C3=NC=C(C=C23)C4=CC=CC=C4)C5CCCC5",5.573,2,1,4]
["S7214","Skepinone-L","f8","L7100-09","in 10mM DMSO","p38 MAPK","MAPK","Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.",425.42,"1221485-83-1",{"v":85,"d":"85.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/skepinone-l.html","C24H21F2NO4","free base","CBS3830","OCC(O)COC1=CC=C2CCC3=CC(=CC=C3C(=O)C2=C1)NC4=CC=C(F)C=C4F",4.729,2,3,6]
["S7218","Alvelestat (AZD9668)","g8","L7100-09","in 10mM DMSO","Serine Protease","Proteases","Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.\n\n Phase 2.",545.53,"848141-11-7",{"v":100,"d":"100.00"},183.31,"<1","N/A","http://selleckchem.com/products/avelestat-azd9668.html","C25H22F3N5O4S","free base","Avelestat","C[N]1N=CC=C1C2=CN(C(=O)C(=C2)C(=O)NCC3=NC=C(C=C3)[S](C)(=O)=O)C4=CC=CC(=C4)C(F)(F)F",2.163,6,1,7]
["S7223","RepSox (E-616452)","h8","L7100-09","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.",287.32,"446859-33-2",{"v":57,"d":"57.00"},198.39,"<1","N/A","http://selleckchem.com/products/repsox.html","C17H13N5","free base","SJN 2511,ALK5 Inhibitor II","CC1=CC=CC(=N1)C2=N[NH]C=C2C3=CC=C4N=CC=CC4=N3",3.192,4,1,2]
["S7229","RGFP966","a9","L7100-09","in 10mM DMSO","HDAC","Epigenetics","RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.",{"v":362.4,"d":"362.40"},"1396841-57-8",{"v":72,"d":"72.00"},198.68,"<1","N/A","http://selleckchem.com/products/rgfp966.html","C21H19FN4O","free base","N/A","NC1=CC(=CC=C1NC(=O)\\C=C\\C2=C[N](C\\C=C\\C3=CC=CC=C3)N=C2)F",3.242,2,2,6]
["S7233","Bromosporine","b9","L7100-09","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.",404.44,"1619994-69-2",{"v":81,"d":"81.00"},200.28,"<1","N/A","http://selleckchem.com/products/bromosporine.html","C17H20N6O4S","free base","N/A","CCOC(=O)NC1=CC(=N[N]2C(=NN=C12)C)C3=CC(=C(C)C=C3)N[S](C)(=O)=O",{"v":1.57,"d":"1.570"},7,2,6]
["S7251","KPT-276","c9","L7100-09","in 10mM DMSO","CRM1","Transmembrane Transporters","KPT-276 is an orally bioavailable selective CRM1 inhibitor.",426.26,"1421919-75-6",{"v":20,"d":"20.00"},46.92,"<1","N/A","http://selleckchem.com/products/kpt-276.html","C16H10F8N4O","free base","N/A","FC1(F)CN(C1)C(=O)\\C=C/[N]2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F",3.025,3,0,5]
["S7252","Selinexor (KPT-330)","d9","L7100-09","in 10mM DMSO","CRM1","Transmembrane Transporters","Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.",443.31,"1393477-72-9",{"v":88,"d":"88.00"},198.51,"<1","N/A","http://selleckchem.com/products/kpt-330.html","C17H11F6N7O","free base","ATG-010","FC(F)(F)C1=CC(=CC(=C1)C2=N[N](\\C=C/C(=O)NNC3=CN=CC=N3)C=N2)C(F)(F)F",2.345,5,2,7]
["S7253","AZD2858","e9","L7100-09","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.",453.52,"486424-20-8",{"v":7,"d":"7.00"},15.43,"<1","N/A","http://selleckchem.com/products/azd2858.html","C21H23N7O3S","free base","N/A","CN1CCN(CC1)[S](=O)(=O)C2=CC=C(C=C2)C3=CN=C(N)C(=N3)C(=O)NC4=CN=CC=C4",0.405,6,2,5]
["S7257","CNX-774","f9","L7100-09","in 10mM DMSO","BTK","Angiogenesis","CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.",{"v":499.5,"d":"499.50"},"1202759-32-7",{"v":100,"d":"100.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://selleckchem.com/products/cnx-774.html","C26H22FN7O3","free base","N/A","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC3=NC(=C(F)C=N3)NC4=CC=CC(=C4)NC(=O)C=C)C=C2",4.281,6,4,9]
["S7261","Beta-Lapachone","g9","L7100-09","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.",242.27,"4707-32-8",{"v":33,"d":"33.00"},136.21,"<1","N/A","http://selleckchem.com/products/beta-lapachone.html","C15H14O3","free base","β-Lapachone, ARQ-501","CC1(C)CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O",2.509,3,0,0]
["S7266","Golgicide A","h9","L7100-09","in 10mM DMSO","ATPase","Transmembrane Transporters","Golgicide A is a potent and rapidly reversible GBF1 inhibitor.",{"v":284.3,"d":"284.30"},"1139889-93-2",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/golgicide-a.html","C17H14F2N2","free base","N/A","FC1=CC2=C(NC(C3CC=CC23)C4=CN=CC=C4)C(=C1)F",3.253,1,1,1]
["S7276","SGI-1027","a10","L7100-09","in 10mM DMSO","Apoptosis related,DNA Methyltransferase","Epigenetics","SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.",461.52,"1020149-73-8",{"v":92,"d":"92.00"},199.34,"<1","N/A","http://selleckchem.com/products/sgi-1027.html","C27H23N7O","free base","DNA Methyltransferase Inhibitor II","CC1=CC(=NC(=N1)N)NC2=CC=C(NC(=O)C3=CC=C(NC4=CC=NC5=C4C=CC=C5)C=C3)C=C2",4.718,4,4,6]
["S7281","JIB-04","b10","L7100-09","in 10mM DMSO","Apoptosis related,Histone Demethylase,JMJD","Epigenetics","JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.",308.76,"199596-05-9",{"v":25,"d":"25.00"},80.97,"<1","N/A","http://selleckchem.com/products/jib-04.html","C17H13ClN4","free base","NSC 693627","ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1",4.424,3,1,4]
["S7282","NMS-E973","c10","L7100-09","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.",454.43,"1253584-84-7",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/nms-e973.html","C22H22N4O7","free base","N/A","CN1CCC(CC1)NC(=O)C2=NOC(=C2)C3=C(OC4=CC=C(C=C4)[N+]([O-])=O)C=C(O)C=C3O",2.811,4,3,6]
["S7284","Rociletinib (CO-1686)","d10","L7100-09","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.",555.55,"1374640-70-6",{"v":100,"d":"100.00"},{"v":180,"d":"180.00"},"<1","N/A","http://selleckchem.com/products/co-1686.html","C27H28F3N7O3","free base","AVL-301","COC1=C(NC2=NC=C(C(=N2)NC3=CC=CC(=C3)NC(=O)C=C)C(F)(F)F)C=CC(=C1)N4CCN(CC4)C(C)=O",4.334,5,3,9]
["S7285","NMS-873","e10","L7100-09","in 10mM DMSO","p97","Ubiquitin","NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).",520.67,"1418013-75-8",{"v":100,"d":"100.00"},192.06,"<1","N/A","http://selleckchem.com/products/nms-873.html","C27H28N4O3S2","free base","N/A","CC1=CC(=CC=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3=NN=C(SC4CCCC4)[N]3C5=CN=CC=C5",5.602,6,0,8]
["S7289","PFK15","f10","L7100-09","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.",260.29,"4382-63-2",{"v":19,"d":"19.00"},{"v":73,"d":"73.00"},"<1","N/A","http://selleckchem.com/products/pfk15.html","C17H12N2O","free base","PFK-015","O=C(\\C=C\\C1=CC=C2C=CC=CC2=N1)C3=CC=NC=C3",3.166,3,0,3]
["S7291","TAK-632","g10","L7100-09","in 10mM DMSO","Raf","MAPK","TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.",554.52,"1228591-30-7",{"v":100,"d":"100.00"},180.34,"<1","N/A","http://selleckchem.com/products/tak-632.html","C27H18F4N4O3S","free base","N/A","FC1=C(NC(=O)CC2=CC=CC(=C2)C(F)(F)F)C=C(OC3=C(C#N)C4=C(C=C3)N=C(NC(=O)C5CC5)S4)C=C1",{"v":5.74,"d":"5.740"},4,2,8]
["S7292","RG2833 (RGFP109)","h10","L7100-09","in 10mM DMSO","HDAC","Epigenetics","RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3 in cell-free assays, respectively.",339.43,"1215493-56-3",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://selleckchem.com/products/rg2833-rgfp109.html","C20H25N3O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N",2.895,2,3,8]
["S7300","PJ34 HCl","a11","L7100-09","in 10mM DMSO","PARP","DNA Damage/DNA Repair","PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.",{"v":331.8,"d":"331.80"},"344458-15-7",{"v":66,"d":"66.00"},198.92,{"v":66,"d":"66.00"},198.92,"http://selleckchem.com/products/pj34-hcl.html","C17H17N3O2.HCl","Hydrochloride","N/A","Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=C2C=CC=C3)C=C1",1.811,2,2,3]
["S7309","BAY 87-2243","b11","L7100-09","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7316","STF-118804","c11","L7100-09","in 10mM DMSO","NAMPT","Metabolism","STF-118804 is a highly specific NAMPT inhibitor.",461.53,"894187-61-2",{"v":61,"d":"61.00"},132.17,"<1","N/A","http://selleckchem.com/products/stf-118804.html","C25H23N3O4S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)CC2=C(C)OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4",3.249,6,1,7]
["S7326","Tasisulam","d11","L7100-09","in 10mM DMSO","Caspase","Apoptosis","Tasisulam (LY573636) is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.",415.11,"519055-62-0",{"v":83,"d":"83.00"},199.95,"<1","N/A","http://selleckchem.com/products/tasisulam.html","C11H6BrCl2NO3S2","free base","LY573636","ClC1=CC(=C(C=C1)C(=O)N[S](=O)(=O)C2=CC=C(Br)S2)Cl",3.872,3,1,3]
["S7329","IOWH032","e11","L7100-09","in 10mM DMSO","CFTR","Transmembrane Transporters","IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.",545.18,"1191252-49-9",{"v":100,"d":"100.00"},183.43,"<1","N/A","http://selleckchem.com/products/iowh032.html","C22H15Br2N3O4","free base","N/A","OC1=C(Br)C=C(C=C1Br)C2=NOC(=N2)C(=O)NCC3=CC=C(OC4=CC=CC=C4)C=C3",5.233,5,2,6]
["S7333","K-Ras(G12C) inhibitor 6","f11","L7100-09","in 10mM DMSO","Ras","Cell Cycle","K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).",405.34,"2060530-16-5",{"v":81,"d":"81.00"},199.83,"<1","N/A","http://selleckchem.com/products/k-ras-g12c-inhibitor-6.html","C17H22Cl2N2O3S","free base","N/A","SCCCC(=O)NC1CCN(CC1)C(=O)COC2=CC=C(Cl)C=C2Cl",2.441,3,1,7]
["S7352","Bay 11-7085","g11","L7100-09","in 10mM DMSO","IκB/IKK","NF-κB","BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.",249.33,"196309-76-9",{"v":50,"d":"50.00"},200.54,"<1","N/A","http://selleckchem.com/products/bay-11-7085.html","C13H15NO2S","free base","Bay 11-7083","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",2.635,2,0,3]
["S7357","PF-562271 HCl","h11","L7100-09","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.",543.95,"939791-41-0",{"v":100,"d":"100.00"},183.84,"<1","N/A","http://selleckchem.com/products/pf-562271-hcl.html","C21H21ClF3N7O3S","Hydrochloride","N/A","Cl.CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O",2.873,6,3,8]
["S7358","Poziotinib (HM781-36B)","a2","L7100-10","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.",491.34,"1092364-38-9",{"v":98,"d":"98.00"},199.45,"<1","N/A","http://selleckchem.com/products/poziotinib-hm781-36b.html","C23H21Cl2FN4O3","free base","NOV120101","COC1=CC2=C(C=C1OC3CCN(CC3)C(=O)C=C)C(=NC=N2)NC4=CC=C(Cl)C(=C4F)Cl",5.046,5,1,6]
["S7360","Birabresib (OTX015)","b2","L7100-10","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",491.99,"202590-98-5",{"v":98,"d":"98.00"},199.19,"<1","N/A","http://selleckchem.com/products/otx015.html","C25H22ClN5O2S","free base","MK 8628","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(O)C=C4)N=C2C5=CC=C(Cl)C=C5)C",4.709,4,2,4]
["S7370","4E1RCat","c2","L7100-10","in 10mM DMSO","eIF","Cell Cycle","4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.",478.45,"328998-25-0",{"v":96,"d":"96.00"},200.65,"<1","N/A","http://selleckchem.com/products/4e1rcat.html","C28H18N2O6","free base","N/A","OC(=O)C1=CC=C(C=C1)N2C(=O)\\C(=C\\C3=CC=C(O3)C4=CC=C(C=C4)[N+]([O-])=O)C=C2C5=CC=CC=C5",5.414,3,0,6]
["S7381","Pepstatin A","d2","L7100-10","in 10mM DMSO","Autophagy,Cysteine Protease,HIV Protease","Proteases","Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.",685.89,"26305-03-3",{"v":57,"d":"57.00"},{"v":83.1,"d":"83.10"},"<1","N/A","http://selleckchem.com/products/pepstatin-a.html","C34H63N5O9","free base","Pepstatin","CC(C)CC(NC(=O)C(C)NC(=O)CC(O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)C(O)CC(O)=O",2.301,6,7,22]
["S7392","Loxistatin Acid (E-64C)","e2","L7100-10","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Loxistatin Acid (E-64C, NSC 694279, EP 475), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry.",314.38,"76684-89-4",{"v":62,"d":"62.00"},197.21,{"v":2,"d":"2.00"},6.36,"http://selleckchem.com/products/loxistatin-acid-e-64c.html","C15H26N2O5","free base","NSC 694279, EP 475","CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(O)=O",1.037,4,2,9]
["S7397","Sorafenib (BAY 43-9006)","f2","L7100-10","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1","N/A","http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7399","FLI-06","g2","L7100-10","in 10mM DMSO","Notch","Stem Cells & Wnt","FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.",438.52,"313967-18-9",{"v":88,"d":"88.00"},200.67,"<1","N/A","http://selleckchem.com/products/fli-06.html","C25H30N2O5","free base","N/A","CC1=C(C(C2=CC=C(C=C2)[N+]([O-])=O)C3=C(CC(C)(C)CC3=O)N1)C(=O)OC4CCCCC4",{"v":4.32,"d":"4.320"},3,1,5]
["S7409","Anisomycin","h2","L7100-10","in 10mM DMSO","Apoptosis related,Autophagy,JNK","MAPK","Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.",{"v":265.3,"d":"265.30"},"22862-76-6",{"v":41,"d":"41.00"},154.54,"<1","N/A","http://selleckchem.com/products/anisomycin.html","C14H19NO4","free base","Flagecidin, Wuningmeisu C","COC1=CC=C(CC2NCC(O)C2OC(C)=O)C=C1",0.877,3,2,5]
["S7414","Caffeic Acid Phenethyl Ester","a3","L7100-10","in 10mM DMSO","NF-κB","NF-κB","Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.",284.31,"104594-70-9",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/caffeic-acid-phenethyl-ester.html","C17H16O4","free base","CAPE, Phenylethyl Caffeate","OC1=CC=C(/C=C/C(=O)OCCC2=CC=CC=C2)C=C1O",3.573,2,2,6]
["S7417","Puromycin (CL13900) 2HCl","b3","L7100-10","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Selection Antibiotics for Transfected Cell","Microbiology","Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.",544.43,"58-58-2",{"v":100,"d":"100.00"},183.68,{"v":100,"d":"100.00"},183.68,"http://selleckchem.com/products/Puromycin-2HCl.html","C22H29N7O5.2HCl","Dihydrochloride","N/A","Cl.Cl.COC1=CC=C(CC(N)C(=O)NC2C(O)C(OC2CO)[N]3C=NC4=C3N=CN=C4N(C)C)C=C1",0.586,6,4,8]
["S7436","NH125","c3","L7100-10","in 10mM DMSO","CaMK","Neuronal Signaling","NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.",524.56,"278603-08-0",{"v":100,"d":"100.00"},190.64,"<1","N/A","http://selleckchem.com/products/nh125.html","C27H45IN2","iodide","N/A","[I-].CCCCCCCCCCCCCCCC[N+]1=C(C)[N](CC2=CC=CC=C2)C=C1",6.032,0,0,17]
["S7440","Ribociclib (LEE011)","d3","L7100-10","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.",434.54,"1211441-98-3",{"v":7,"d":"7.00"},16.11,"<1","N/A","http://selleckchem.com/products/lee011.html","C23H30N8O","free base","N/A","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",{"v":2.9,"d":"2.900"},4,2,5]
["S7447","ZLN005","e3","L7100-10","in 10mM DMSO","PGC-1α","Metabolism","ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.",250.34,"49671-76-3",{"v":37,"d":"37.00"},{"v":147.8,"d":"147.80"},"<1","N/A","http://selleckchem.com/products/ZLN005.html","C17H18N2","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3[NH]2",{"v":4.67,"d":"4.670"},1,1,2]
["S7451","FPH1 (BRD-6125)","f3","L7100-10","in 10mM DMSO","Others","Others","FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.",388.82,"708219-39-0",{"v":78,"d":"78.00"},200.61,"<1","N/A","http://selleckchem.com/products/fph1-brd-6125.html","C16H15ClF2N2O3S","free base","N/A","CC1=CC=C(Cl)C=C1N(CC(=O)NC2=C(F)C=CC=C2F)[S](C)(=O)=O",3.145,3,1,5]
["S7458","VER-49009","g3","L7100-10","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-49009 (CCT0129397) is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.",387.82,"940289-57-6",{"v":77,"d":"77.00"},198.55,"<1","N/A","http://selleckchem.com/products/ver-49009.html","C19H18ClN3O4","free base","CCT0129397","CCNC(=O)C1=C(C2=CC=C(OC)C=C2)C(=N[NH]1)C3=CC(=C(O)C=C3O)Cl",3.751,3,4,5]
["S7466","GGTI 298 TFA salt","h3","L7100-10","in 10mM DMSO","Transferase","Metabolism","GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.",593.66,"1217457-86-7",{"v":100,"d":"100.00"},168.45,"<1","N/A","http://selleckchem.com/products/ggti-298.html","C27H33N3O3S.C2HF3O2","trifluoroacetat","N/A","COC(=O)C(CC(C)C)NC(=O)C1=CC=C(NCC(N)CS)C=C1C2=C3C=CC=CC3=CC=C2.OC(=O)C(F)(F)F",2.733,4,3,12]
["S7467","LB42708","a4","L7100-10","in 10mM DMSO","FTase,Transferase","Metabolism","LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.",555.46,"226929-39-1",{"v":100,"d":"100.00"},180.03,"<1","N/A","http://selleckchem.com/products/lb42708.html","C30H27BrN4O2","free base","N/A","BrC1=CC=C(C[N]2C=NC=C2C[N]3C=C(C(=O)N4CCOCC4)C(=C3)C5=C6C=CC=CC6=CC=C5)C=C1",4.744,3,0,6]
["S7470","Triapine","b4","L7100-10","in 10mM DMSO","DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.",195.24,"200933-27-3",{"v":20,"d":"20.00"},102.44,"<1","N/A","http://selleckchem.com/products/triapine.html","C7H9N5S","free base","3-AP","NC(=S)N/N=C/C1=NC=CC=C1N",0.331,2,3,3]
["S7473","Nexturastat A","c4","L7100-10","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.",{"v":341.4,"d":"341.40"},"1403783-31-2",{"v":68,"d":"68.00"},199.18,"<1","N/A","http://selleckchem.com/products/nexturastat-a.html","C19H23N3O3","free base","N/A","CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2",3.079,2,2,7]
["S7488","MPI-0479605","d4","L7100-10","in 10mM DMSO","MPS1","Cell Cycle","MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.",407.51,"1246529-32-7",{"v":62,"d":"62.00"},152.14,"<1","N/A","http://selleckchem.com/products/mpi-0479605.html","C22H29N7O","free base","N/A","CC1=CC(=CC=C1NC2=NC3=C(N=C[NH]3)C(=N2)NC4CCCCC4)N5CCOCC5",4.379,4,3,5]
["S7492","Uprosertib (GSK2141795)","e4","L7100-10","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Uprosertib (GSK2141795, GSK795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.",429.25,"1047634-65-0",{"v":85,"d":"85.00"},198.02,"<1","N/A","http://selleckchem.com/products/gsk2141795.html","C18H16Cl2F2N4O2","free base","GSK795","C[N]1N=CC(=C1C2=C(Cl)OC(=C2)C(=O)NC(CN)CC3=CC(=C(F)C=C3)F)Cl",3.531,3,2,6]
["S7505","(S)-crizotinib","f4","L7100-10","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.",450.34,"1374356-45-2",{"v":42,"d":"42.00"},93.26,"<1","N/A","http://selleckchem.com/products/s-crizotinib.html","C21H22Cl2FN5O","free base","N/A","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S7516","Y-320","g4","L7100-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.",505.01,"288250-47-5",{"v":11,"d":"11.00"},21.78,"<1","N/A","http://selleckchem.com/products/y-320.html","C27H29ClN6O2","free base","N/A","CC1=C(C=N[N]1C2=CC=C(Cl)C=C2)C(=O)NC3=CC=C(N4CCC(CC4)N5CCOCC5)C(=C3)C#N",{"v":3.49,"d":"3.490"},3,1,5]
["S7520","Darapladib (SB-480848)","h4","L7100-10","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.",666.77,"356057-34-6",{"v":100,"d":"100.00"},149.98,"<1","N/A","http://selleckchem.com/products/darapladib-sb-480848.html","C36H38F4N4O2S","free base","N/A","CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCC5=CC=C(F)C=C5",7.707,3,0,14]
["S7521","Afuresertib (GSK2110183)","a5","L7100-10","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.",427.32,"1047644-62-1",{"v":85,"d":"85.00"},198.91,"<1","N/A","http://selleckchem.com/products/afuresertib-gsk2110183.html","C18H17Cl2FN4OS","free base","N/A","C[N]1N=CC(=C1C2=C(Cl)SC(=C2)C(=O)NC(CN)CC3=CC=CC(=C3)F)Cl",3.884,2,2,6]
["S7523","Entospletinib (GS-9973)","b5","L7100-10","in 10mM DMSO","Syk","Angiogenesis","Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.",411.46,"1229208-44-9",{"v":26,"d":"26.00"},63.19,"<1","N/A","http://selleckchem.com/products/gs-9973.html","C23H21N7O","free base","N/A","C1CN(CCO1)C2=CC=C(NC3=NC(=C[N]4C=CN=C34)C5=CC=C6C=N[NH]C6=C5)C=C2",2.949,4,2,4]
["S7536","Lorlatinib (PF-6463922)","c5","L7100-10","in 10mM DMSO","ALK,Apoptosis related,ROS1","Protein Tyrosine Kinase","Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 induces apoptosis. Phase 1.",406.41,"1454846-35-5",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/pf-06463922.html","C21H19FN6O2","free base","N/A","CC1OC2=C(N)N=CC(=C2)C3=C(C#N)[N](C)N=C3CN(C)C(=O)C4=C1C=C(F)C=C4",2.343,4,1,0]
["S7539","PTC-209 HBr","d5","L7100-10","in 10mM DMSO","BMI-1","Cell Cycle","PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).",{"v":576.1,"d":"576.10"},"1217022-63-3",{"v":100,"d":"100.00"},173.58,"<1","N/A","http://selleckchem.com/products/ptc-209-hbr.html","C17H13Br2N5OS.HBr","free base","N/A","Br.COC1=CC(=C(NC2=NC(=CS2)C3=C(C)N=C4N=CC=C[N]34)C(=C1)Br)Br",5.362,4,1,4]
["S7573","GSK2830371","e5","L7100-10","in 10mM DMSO","phosphatase","Others","GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.",461.02,"1404456-53-6",{"v":92,"d":"92.00"},199.56,"<1","N/A","http://selleckchem.com/products/gsk2830371.html","C23H29ClN4O2S","free base","N/A","CC1=NC=C(Cl)C=C1NCC2=CC=C(S2)C(=O)NC(CC3CCCC3)C(=O)NC4CC4",4.064,3,3,9]
["S7605","Filgotinib (GLPG0634)","f5","L7100-10","in 10mM DMSO","JAK","JAK/STAT","Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.",{"v":425.5,"d":"425.50"},"1206161-97-8",{"v":85,"d":"85.00"},199.76,"<1","N/A","http://selleckchem.com/products/filgotinib.html","C21H23N5O3S","free base","N/A","O=C(NC1=N[N]2C(=N1)C=CC=C2C3=CC=C(CN4CC[S](=O)(=O)CC4)C=C3)C5CC5",2.461,5,1,5]
["S7625","Niraparib (MK-4827) tosylate","g5","L7100-10","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.",492.59,"1038915-73-9",{"v":98,"d":"98.00"},198.95,"<1","N/A","http://selleckchem.com/products/mk-4827-niraparib-tosylate.html","C19H20N4O.C7H8O3S","4-?methylbenzen","Niraparib tosylate, MK 4827 tosylate, ZEJULA","CC1=CC=C(C=C1)[S](O)(=O)=O.NC(=O)C2=CC=CC3=C[N](N=C23)C4=CC=C(C=C4)C5CCCNC5",4.267,2,2,4]
["S7633","Lomitapide Mesylate","h5","L7100-10","in 10mM DMSO","MTP","Transmembrane Transporters","Lomitapide Mesylate(AEGR-733 Mesylate,BMS-2138 Mesylate) is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.",789.83,"202914-84-9",{"v":100,"d":"100.00"},126.61,"<1","N/A","http://selleckchem.com/products/lomitapide-mesylate.html","C40H41F6N3O5S","Mesylate","AEGR-733 Mesylate,BMS-2138 Mesylate","C[S](O)(=O)=O.FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)C5=C(C=CC=C5)C6=C1C=CC=C6",7.377,2,2,12]
["S7634","Cerdulatinib (PRT062070) hydrochloride","a6","L7100-10","in 10mM DMSO","JAK,Syk","JAK/STAT","Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.",{"v":482,"d":"482.00"},"1369761-01-2",{"v":43,"d":"43.00"},89.21,"<1","N/A","http://selleckchem.com/products/cerdulatinib-prt062070-prt2070.html","C20H28ClN7O3S","hydrochloride","PRT2070 hydrochloride","Cl.CC[S](=O)(=O)N1CCN(CC1)C2=CC=C(NC3=NC(=C(C=N3)C(N)=O)NC4CC4)C=C2",1.862,5,3,8]
["S7642","D 4476","b6","L7100-10","in 10mM DMSO","Casein Kinase","Metabolism","D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.",398.41,"301836-43-1",{"v":79,"d":"79.00"},198.29,"<1","N/A","http://selleckchem.com/products/d-4476.html","C23H18N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=CC=N3)C4=CC5=C(OCCO5)C=C4",3.464,5,2,4]
["S7645","Pilaralisib (XL147)","c6","L7100-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.",541.02,"934526-89-3",{"v":100,"d":"100.00"},184.84,"<1","N/A","http://selleckchem.com/products/pilaralisib-xl147.html","C25H25ClN6O4S","free base","N/A","COC1=CC(=C(Cl)C=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=CC(=C4)NC(=O)C(C)(C)N",4.012,6,4,8]
["S7646","Voxtalisib (XL765)","d6","L7100-10","in 10mM DMSO","mTOR,PI3K","Angiogenesis","Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",270.29,"934493-76-2",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/voxtalisib-xl765-sar245409.html","C13H14N6O","free base","SAR245409","CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C3=CC=N[NH]3",0.838,4,2,2]
["S7651","SB225002","e6","L7100-10","in 10mM DMSO","CXCR","GPCR & G Protein","SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.",352.14,"182498-32-4",{"v":70,"d":"70.00"},198.78,"<1","N/A","http://selleckchem.com/products/sb225002.html","C13H10BrN3O4","free base","N/A","OC1=CC(=CC=C1NC(=O)NC2=C(Br)C=CC=C2)[N+]([O-])=O",2.923,1,3,3]
["S7653","PND-1186 (VS-4718)","f6","L7100-10","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","PND-1186 (VS-4718, SR-2156) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis. Phase 1.",{"v":501.5,"d":"501.50"},"1061353-68-1",{"v":24,"d":"24.00"},47.86,"<1","N/A","http://selleckchem.com/products/pnd-1186-vs-4718.html","C25H26F3N5O3","free base","SR-2156","CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3OC)N4CCOCC4",4.302,4,3,8]
["S7741","SB239063","g6","L7100-10","in 10mM DMSO","p38 MAPK","MAPK","SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.",{"v":368.4,"d":"368.40"},"193551-21-2",{"v":60,"d":"60.00"},162.87,"<1","N/A","http://selleckchem.com/products/sb239063.html","C20H21FN4O2","free base","N/A","COC1=NC=CC(=N1)C2=C(N=C[N]2C3CCC(O)CC3)C4=CC=C(F)C=C4",3.661,4,1,4]
["S7754","Gilteritinib (ASP2215)","h6","L7100-10","in 10mM DMSO","Axl,FLT3","Protein Tyrosine Kinase","Gilteritinib (ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).",552.71,"1254053-43-4",{"v":100,"d":"100.00"},180.93,"<1","N/A","http://selleckchem.com/products/gilteritinib-asp2215.html","C29H44N8O3","free base","N/A","CCC1=NC(=C(NC2=CC=C(N3CCC(CC3)N4CCN(C)CC4)C(=C2)OC)N=C1NC5CCOCC5)C(N)=O",2.401,5,3,9]
["S7765","Dovitinib (TKI258) Lactate monohydrate","a7","L7100-10","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib (TKI258) Lactate monohydrate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.",500.52,"915769-50-5 (monohydrate)",{"v":100,"d":"100.00"},207.25,{"v":66,"d":"66.00"},136.78,"http://selleckchem.com/products/dovitinib-tki258-lactate.html","C24H29FN6O5","Lactate monohydrate","CHIR258","O.CC(O)C(O)=O.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(F)C=CC=C5NC4=O",-1.646,3,4,3]
["S7772","Elacridar (GF120918)","b7","L7100-10","in 10mM DMSO","P-gp","Transmembrane Transporters","Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.",563.64,"143664-11-3",{"v":8,"d":"8.00"},14.19,"<1","N/A","http://selleckchem.com/products/elacridar-gf120918.html","C34H33N3O5","free base","GW120918, GG918, GW0918","COC1=C2NC3=C(C=CC=C3C(=O)NC4=CC=C(CCN5CCC6=C(C5)C=C(OC)C(=C6)OC)C=C4)C(=O)C2=CC=C1",5.742,5,2,8]
["S7781","Sunitinib (SU11248)","c7","L7100-10","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1","N/A","http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7783","Combretastatin A4","d7","L7100-10","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.",316.35,"117048-59-6",{"v":63,"d":"63.00"},199.15,"<1","N/A","http://selleckchem.com/products/combretastatin-a4.html","C18H20O5","free base","N/A","COC1=C(O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",3.508,4,1,6]
["S7786","Erlotinib (OSI-774)","e7","L7100-10","in 10mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.",393.44,"183321-74-6",{"v":78,"d":"78.00"},198.25,"<1","N/A","http://selleckchem.com/products/erlotinib.html","C22H23N3O4","free base","CP358774, NSC 718781, Tarceva","COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.309,6,1,10]
["S7787","Docetaxel Trihydrate","f7","L7100-10","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",861.93,"148408-66-6",{"v":100,"d":"100.00"},116.02,"<1","N/A","http://selleckchem.com/products/docetaxel-trihydrate.html","C43H53NO14.3H2O","Trihydrate","RP56976 (NSC 628503) Trihydrate","O.O.O.CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",1.964,10,4,13]
["S7810","Afatinib (BIBW2992) Dimaleate","g7","L7100-10","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.",717.18,"850140-73-7",{"v":100,"d":"100.00"},139.44,"<1","N/A","http://selleckchem.com/products/afatinib-bibw2992-dimaleate.html","C24H25ClFN5O3.2C4H4O4","Dimaleate","N/A","CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",{"v":0.96,"d":"0.960"},9,2,12]
["S7828","Licochalcone A","h7","L7100-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.",{"v":338.4,"d":"338.40"},"58749-22-7",{"v":67,"d":"67.00"},197.99,"<1","N/A","http://selleckchem.com/products/licochalcone-a.html","C21H22O4","free base","N/A","COC1=C(/C=C/C(=O)C2=CC=C(O)C=C2)C=C(C(=C1)O)C(C)(C)C=C",4.667,2,2,6]
["S7854","Ulixertinib (BVD-523)","a8","L7100-10","in 10mM DMSO","ERK","MAPK","Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.",433.33,"869886-67-9",{"v":86,"d":"86.00"},198.46,"<1","N/A","http://selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html","C21H22Cl2N4O2","free base","VRT752271","CC(C)NC1=NC=C(Cl)C(=C1)C2=C[NH]C(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl",4.266,2,4,7]
["S7858","Dibutyryl-cAMP (Bucladesine)","b8","L7100-10","in 10mM DMSO","PDE,PKA","GPCR & G Protein","Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.",491.37,"16980-89-5",{"v":98,"d":"98.00"},199.44,{"v":98,"d":"98.00"},199.44,"http://selleckchem.com/products/dibutyryl-camp-bucladesine.html","C18H23N5NaO8P","sodium salt","dbcAMP","CCCC(=O)NC1=NC=NC2=C1N=C[N]2C3OC4CO[P](=O)(O[Na])OC4C3OC(=O)CCC",1.028,10,1,9]
["S7864","Oltipraz","c8","L7100-10","in 10mM DMSO","Nrf2","Immunology & Inflammation","Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.",226.34,"64224-21-1",{"v":39,"d":"39.00"},172.31,"<1","N/A","http://selleckchem.com/products/oltipraz.html","C8H6N2S3","free base","N/A","CC1=C(SSC1=S)C2=NC=CN=C2",2.225,2,0,1]
["S7875","NVP-CGM097","d8","L7100-10","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7917","Kenpaullone","e8","L7100-10","in 10mM DMSO","CDK","Cell Cycle","Kenpaullone (9-Bromopaullone, NSC-664704) is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.",327.18,"142273-20-9",{"v":65,"d":"65.00"},198.67,"<1","N/A","http://selleckchem.com/products/kenpaullone.html","C16H11BrN2O","free base","9-Bromopaullone, NSC-664704","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3C=CC=C4)C=C1",3.671,1,2,0]
["S7924","Bay K 8644","f8","L7100-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.",{"v":356.3,"d":"356.30"},"71145-03-4",{"v":71,"d":"71.00"},199.27,"<1","N/A","http://selleckchem.com/products/bay-k-8644.html","C16H15F3N2O4","free base","N/A","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)C(F)(F)F)[N+]([O-])=O)C",2.673,2,1,5]
["S7935","Y-39983 HCl","g8","L7100-10","in 10mM DMSO","ROCK","Cell Cycle","Y-39983 HCl (Y-33075) is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.",353.25,"173897-44-4",{"v":63,"d":"63.00"},178.34,{"v":63,"d":"63.00"},178.34,"http://selleckchem.com/products/y-39983-hcl.html","C16H16N4O.2HCl","dihydrochloride","Y-33075 HCl","Cl.Cl.CC(N)C1=CC=C(C=C1)C(=O)NC2=C3C=C[NH]C3=NC=C2",2.204,2,3,3]
["S7936","Belumosudil (KD025)","h8","L7100-10","in 10mM DMSO","ROCK","Cell Cycle","Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.",452.51,"911417-87-3",{"v":90,"d":"90.00"},198.89,"<1","N/A","http://selleckchem.com/products/kd025-(slx-2119).html","C26H24N6O2","free base","SLx-2119","CC(C)NC(=O)COC1=CC(=CC=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C([NH]N=C5)C=C4",{"v":4.51,"d":"4.510"},5,3,7]
["S7963","TIC10 (ONC201)","a9","L7100-10","in 10mM DMSO","Akt,Apoptosis related,ERK,TNF-alpha","PI3K/Akt/mTOR","TIC10 (ONC201) inactivates Akt and ERK to induce TNF-related apoptosis-inducing ligand (TRAIL) through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"1616632-77-9",{"v":77,"d":"77.00"},199.23,"<1","N/A","http://selleckchem.com/products/tic-10.html","C24H26N4O","free base","ONC201","CC1=CC=CC=C1CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25",3.212,2,0,4]
["S7975","Favipiravir (T-705)","b9","L7100-10","in 10mM DMSO","COVID-19,DNA/RNA Synthesis,Influenza Virus","DNA Damage/DNA Repair","Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.",{"v":157.1,"d":"157.10"},"259793-96-9",{"v":31,"d":"31.00"},197.33,{"v":5,"d":"5.00"},31.83,"http://selleckchem.com/products/favipiravir-t-705.html","C5H4FN3O2","free base","N/A","NC(=O)C1=NC(=CN=C1O)F",-0.157,3,2,1]
["S7977","Napabucasin (BBI608)","c9","L7100-10","in 10mM DMSO","STAT","JAK/STAT","Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.",240.21,"83280-65-3",{"v":10,"d":"10.00"},41.63,"<1","N/A","http://selleckchem.com/products/napabucasin.html","C14H8O4","free base","BBI608","CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O",2.234,4,0,1]
["S7999","SKF96365","d9","L7100-10","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8001","Ricolinostat (ACY-1215)","e9","L7100-10","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.",{"v":433.5,"d":"433.50"},"1316214-52-4",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/rocilinostat-acy-1215.html","C24H27N5O3","free base","Rocilinostat","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",3.917,4,2,11]
["S8003","PQ 401","f9","L7100-10","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.",341.79,"196868-63-0",{"v":32,"d":"32.00"},93.62,"<1","N/A","http://selleckchem.com/products/pq-401.html","C18H16ClN3O2","free base","N/A","COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(=C2)C)C=C(Cl)C=C1",3.639,3,2,3]
["S8005","SMI-4a","g9","L7100-10","in 10mM DMSO","Pim","JAK/STAT","SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.",273.23,"438190-29-5",{"v":55,"d":"55.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/smi-4a.html","C11H6F3NO2S","free base","TCS PIM-1 4a","FC(F)(F)C1=CC(=CC=C1)\\C=C2/SC(=O)NC2=O",2.884,2,1,2]
["S8006","BIX 01294","h9","L7100-10","in 10mM DMSO","Autophagy,G9a/GLP,Histone Methyltransferase,NSD","Epigenetics","BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.",600.02,"1392399-03-9",{"v":98,"d":"98.00"},163.33,{"v":98,"d":"98.00"},163.33,"http://selleckchem.com/products/bix-01294.html","C28H38N6O2.3HCl","trihydrochloride","N/A","Cl.Cl.Cl.COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)CC4=CC=CC=C4)N5CCCN(C)CC5",5.246,4,1,7]
["S8007","VE-821","a10","L7100-10","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.",368.41,"1232410-49-9",{"v":74,"d":"74.00"},200.86,"<1","N/A","http://selleckchem.com/products/ve-821.html","C18H16N4O3S","Free Base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)C2=CN=C(N)C(=N2)C(=O)NC3=CC=CC=C3",2.007,5,2,4]
["S8015","Agerafenib (RXDX-105)","b10","L7100-10","in 10mM DMSO","c-Kit,c-RET,CSF-1R,PDGFR,Raf","MAPK","Agerafenib (RXDX-105, CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.",517.46,"1188910-76-0",{"v":9,"d":"9.00"},17.39,"<1","N/A","http://selleckchem.com/products/cep-32496.html","C24H22F3N5O5","free base","CEP-32496","COC1=CC2=NC=NC(=C2C=C1OC)OC3=CC(=CC=C3)NC(=O)NC4=NOC(=C4)C(C)(C)C(F)(F)F",5.288,8,2,8]
["S8019","Capivasertib (AZD5363)","c10","L7100-10","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.",428.92,"1143532-39-1",{"v":86,"d":"86.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://selleckchem.com/products/azd5363.html","C21H25ClN6O2","free base","N/A","NC1(CCN(CC1)C2=NC=NC3=C2C=C[NH]3)C(=O)NC(CCO)C4=CC=C(Cl)C=C4",1.317,3,4,6]
["S8024","Tyrphostin AG 1296","d10","L7100-10","in 10mM DMSO","Apoptosis related,c-Kit,FGFR,PDGFR","Protein Tyrosine Kinase","Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.",266.29,"146535-11-7",{"v":6,"d":"6.00"},22.53,"<1","N/A","http://selleckchem.com/products/tyrphostin-ag-1296-ag-1296.html","C16H14N2O2","free base","AG 1296","COC1=CC2=NC=C(N=C2C=C1OC)C3=CC=CC=C3",3.208,4,0,3]
["S8031","NSC 23766","e10","L7100-10","in 10mM DMSO","Rho","Cell Cycle","NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related  targets, Cdc42 or RhoA.",530.96,"1177865-17-6",{"v":100,"d":"100.00"},188.34,{"v":100,"d":"100.00"},188.34,"http://selleckchem.com/products/nsc-23766.html","C24H35N7.3HCl","HCl","N/A","Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(N)C=C(C)N=C3C=C2)C",5.477,3,3,10]
["S8032","PRT062607 (P505-15) HCl","f10","L7100-10","in 10mM DMSO","FAK,FLT3,Mixed Lineage Kinase,PAK,Pyk2,Src,Syk","Angiogenesis","PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.",429.91,"1370261-97-4",{"v":86,"d":"86.00"},200.04,{"v":86,"d":"86.00"},200.04,"http://selleckchem.com/products/prt062607-p505-15-hcl.html","C19H23N9O.HCl","Hydrochloride","BIIB057, PRT-2607","Cl.NC1CCCCC1NC2=NC=C(C(N)=O)C(=N2)NC3=CC(=CC=C3)[N]4N=CC=N4",2.033,5,4,6]
["S8039","Zelavespib (PU-H71)","g10","L7100-10","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Zelavespib (PU-H71, NSC 750424) is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.",512.37,"873436-91-0",{"v":100,"d":"100.00"},195.17,{"v":34,"d":"34.00"},66.36,"http://selleckchem.com/products/pu-h71.html","C18H21IN6O2S","free base","NSC 750424","CC(C)NCCC[N]1C(=NC2=C(N)N=CN=C12)SC3=CC4=C(OCO4)C=C3I",3.162,5,2,7]
["S8040","GDC-0349","h10","L7100-10","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.",452.55,"1207360-89-1",{"v":91,"d":"91.00"},201.08,"<1","N/A","http://selleckchem.com/products/gdc-0349.html","C24H32N6O3","free base","RG-7603","CCNC(=O)NC1=CC=C(C=C1)C2=NC(=C3CCN(CC3=N2)C4COC4)N5CCOCC5C",1.982,5,2,5]
["S8041","Cobimetinib (GDC-0973)","a11","L7100-10","in 10mM DMSO","Apoptosis related,MEK","MAPK","Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.",531.31,"934660-93-2",{"v":100,"d":"100.00"},188.21,"<1","N/A","http://selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html","C21H21F3IN3O2","free base","RG7420,XL518","OC1(CN(C1)C(=O)C2=C(NC3=CC=C(I)C=C3F)C(=C(F)C=C2)F)C4CCCCN4",3.701,1,2,4]
["S8043","Scriptaid","b11","L7100-10","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Scriptaid (GCK 1026) is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.",326.35,"287383-59-9",{"v":65,"d":"65.00"},199.17,"<1","N/A","http://selleckchem.com/products/scriptaid.html","C18H18N2O4","free base","GCK 1026","ONC(=O)CCCCCN1C(=O)C2=C3C(=CC=C2)C=CC=C3C1=O",2.119,3,1,6]
["S8044","BMS-345541","c11","L7100-10","in 10mM DMSO","IκB/IKK","NF-κB","BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.",255.32,"445430-58-0",{"v":9,"d":"9.00"},35.25,"<1","N/A","http://selleckchem.com/products/bms-345541.html","C14H17N5","free base","N/A","CC1=CC=C2N=C(NCCN)C3=NC=C(C)[N]3C2=C1",1.472,2,2,3]
["S8048","Venetoclax (ABT-199)","d11","L7100-10","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.",868.44,"1257044-40-8",{"v":100,"d":"100.00"},115.15,"<1","N/A","http://selleckchem.com/products/abt-199.html","C45H50ClN7O7S","free base","GDC-0199","CC1(C)CCC(=C(C1)C2=CC=C(Cl)C=C2)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)N[S](=O)(=O)C5=CC=C(NCC6CCOCC6)C(=C5)[N+]([O-])=O)OC7=CN=C8[NH]C=CC8=C7",{"v":7.94,"d":"7.940"},6,3,13]
["S8050","ETP-46464","e11","L7100-10","in 10mM DMSO","ATM/ATR,mTOR","PI3K/Akt/mTOR","ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.",470.52,"1345675-02-6",{"v":6,"d":"6.00"},12.75,"<1","N/A","http://selleckchem.com/products/etp-46464.html","C30H22N4O2","free base","N/A","CC(C)(C#N)C1=CC=C(C=C1)N2C(=O)OCC3=C2C4=C(C=CC(=C4)C5=CN=C6C=CC=CC6=C5)N=C3",5.813,4,0,3]
["S8057","Pacritinib (SB1518)","f11","L7100-10","in 10mM DMSO","FLT3,JAK","JAK/STAT","Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.",472.58,"937272-79-2",{"v":11,"d":"11.00"},23.28,"<1","N/A","http://selleckchem.com/products/pacritinib-sb1518.html","C28H32N4O3","free base","N/A","C1CCN(C1)CCOC2=CC=C3NC4=NC=CC(=N4)C5=CC(=CC=C5)COC\\C=C\\COCC2=C3",4.547,5,1,4]
["S8058","Riviciclib hydrochloride (P276-00)","g11","L7100-10","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Riviciclib hydrochloride (P276-00) induces apoptosis. Phase 2/3.",{"v":438.3,"d":"438.30"},"920113-03-7",{"v":88,"d":"88.00"},200.78,{"v":88,"d":"88.00"},200.78,"http://selleckchem.com/products/p276-00.html","C21H20ClNO5.HCl","hydrochloride","N/A","Cl.CN1CCC(C1CO)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,3]
["S8065","Nutlin-3b","h11","L7100-10","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8077","RI-1","a2","L7100-11","in 10mM DMSO","RAD51","DNA Damage/DNA Repair","RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.",361.61,"415713-60-9",{"v":50,"d":"50.00"},138.27,"<1","N/A","http://selleckchem.com/products/ri-1.html","C14H11Cl3N2O3","free base","RAD51 inhibitor 1","ClC1=CC=C(C=C1Cl)N2C(=O)C(=C(N3CCOCC3)C2=O)Cl",2.544,3,0,2]
["S8078","Bardoxolone Methyl","b2","L7100-11","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8104","SCH58261","c2","L7100-11","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.",345.36,"160098-96-4",{"v":69,"d":"69.00"},199.79,"<1","N/A","http://selleckchem.com/products/sch58261.html","C18H15N7O","free base","N/A","NC1=NC2=C(C=N[N]2CCC3=CC=CC=C3)C4=NC(=N[N]14)C5=CC=CO5",{"v":2.74,"d":"2.740"},5,1,4]
["S8133","Resiquimod (R-848)","d2","L7100-11","in 10mM DMSO","HCV,IFN,Interleukins,TLR,TNF-alpha","Immunology & Inflammation","Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2.",314.38,"144875-48-9",{"v":63,"d":"63.00"},200.39,"<1","N/A","http://selleckchem.com/products/resiquimod.html","C17H22N4O2","free base","S28463","CCOCC1=NC2=C([N]1CC(C)(C)O)C3=C(C=CC=C3)N=C2N",1.919,3,1,5]
["S8135","Riociguat (BAY 63-2521)","e2","L7100-11","in 10mM DMSO","Guanylate Cyclase","GPCR & G Protein","Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.",422.42,"625115-55-1",{"v":84,"d":"84.00"},198.85,"<1","N/A","http://selleckchem.com/products/riociguat-bay-63-2521.html","C20H19FN8O2","free base","N/A","COC(=O)N(C)C1=C(N)N=C(N=C1N)C2=N[N](CC3=CC=CC=C3F)C4=NC=CC=C24",2.341,6,2,5]
["S8144","Halofuginone","f2","L7100-11","in 10mM DMSO","DNA/RNA Synthesis,TGF-beta/Smad","DNA Damage/DNA Repair","Halofuginone (RU-19110) is the competitively inhibitor of  prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.",414.68,"55837-20-2",{"v":20,"d":"20.00"},48.23,"<1","N/A","http://selleckchem.com/products/halofuginone.html","C16H17BrClN3O3","free base","RU-19110","OC1CCCNC1CC(=O)CN2C=NC3=CC(=C(Cl)C=C3C2=O)Br",1.648,3,2,4]
["S8201","BI-78D3","g2","L7100-11","in 10mM DMSO","JNK","MAPK","BI-78D3 is a competitive JNK inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.",379.37,"883065-90-5",{"v":100,"d":"100.00"},263.59,"<1","N/A","http://selleckchem.com/products/bi-78d3.html","C13H9N5O5S2","free base","N/A","OC1=NN=C(SC2=NC=C(S2)[N+]([O-])=O)[N]1C3=CC=C4OCCOC4=C3",2.738,5,1,4]
["S8219","Bitopertin","h2","L7100-11","in 10mM DMSO","Amino acid transporter,GlyT","Neuronal Signaling","Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.",543.46,"845614-11-1",{"v":100,"d":"100.00"},184.01,"<1","N/A","http://selleckchem.com/products/bitopertin-rg1678-ro-4917838.html","C21H20F7N3O4S","free base","RG1678, RO-4917838","CC(OC1=CC=C(C=C1C(=O)N2CCN(CC2)C3=NC=C(C=C3F)C(F)(F)F)[S](C)(=O)=O)C(F)(F)F",4.304,5,0,7]
["S8238","SB366791","a3","L7100-11","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.",287.74,"472981-92-3",{"v":57,"d":"57.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/sb366791.html","C16H14ClNO2","free base","N/A","COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(Cl)C=C2",{"v":3.73,"d":"3.730"},2,1,4]
["S8244","Etomoxir sodium salt","b3","L7100-11","in 10mM DMSO","Apoptosis related,CPT,Transferase","Metabolism","Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.",320.74,"828934-41-4",{"v":64,"d":"64.00"},199.54,{"v":64,"d":"64.00"},199.54,"http://selleckchem.com/products/etomoxir-na-salt.html","C15H18ClO4.Na","sodium salt","(R)-(+)-Etomoxir sodium salt","[Na]OC(=O)C1(CCCCCCOC2=CC=C(Cl)C=C2)CO1",3.847,4,0,10]
["S8322","Samotolisib (LY3023414)","c3","L7100-11","in 10mM DMSO","DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.",406.48,"1386874-06-1",{"v":47,"d":"47.00"},115.63,"<1","N/A","http://selleckchem.com/products/ly3023414.html","C23H26N4O3","free base","GTPL8918","COC(C)CN1C(=O)N(C)C2=C1C3=CC(=CC=C3N=C2)C4=CC(=CN=C4)C(C)(C)O",1.883,4,0,5]
["S8401","Erdafitinib (JNJ-42756493)","d3","L7100-11","in 10mM DMSO","Apoptosis related,c-Kit,c-RET,CSF-1R,FGFR,PDGFR,VEGFR","Angiogenesis","Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Erdafitinib also binds to RET (c-RET), CSF-1R, PDGFR-α/PDGFR-β, FLT4, Kit (c-Kit) and VEGFR-2 and induces cellular apoptosis.",446.54,"1346242-81-6",{"v":89,"d":"89.00"},199.31,"<1","N/A","http://selleckchem.com/products/jnj-42756493-erdafitinib.html","C25H30N6O2","free base","N/A","COC1=CC(=CC(=C1)N(CCNC(C)C)C2=CC3=NC(=CN=C3C=C2)C4=C[N](C)N=C4)OC",3.943,5,1,9]
["S8419","Stenoparib (E7449)","e3","L7100-11","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.",317.34,"1140964-99-3",{"v":4,"d":"4.00"},{"v":12.6,"d":"12.60"},"<1","N/A","http://selleckchem.com/products/e7449.html","C18H15N5O","free base","2X-121, MGI25036","O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5",1.436,3,2,2]
["S8558","Tofogliflozin(CSG 452)","f3","L7100-11","in 10mM DMSO","SGLT","GPCR & G Protein","Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.",404.45,"1201913-82-7",{"v":84,"d":"84.00"},207.69,{"v":4,"d":"4.00"},9.89,"http://selleckchem.com/products/tofogliflozin-csg-452.html","C22H26O6.H2O","hydrate","N/A","O.CCC1=CC=C(CC2=CC3=C(COC34OC(CO)C(O)C(O)C4O)C=C2)C=C1",{"v":1.92,"d":"1.920"},2,4,4]
["S8567","Tucidinostat (Chidamide)","g3","L7100-11","in 10mM DMSO","HDAC","Epigenetics","Tucidinostat (Chidamide, HBI-8000, CS-055) is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.",390.41,"1616493-44-7",{"v":78,"d":"78.00"},199.79,"<1","N/A","http://selleckchem.com/products/tucidinostat-chidamide.html","C22H19FN4O2","free base","HBI-8000, CS-055","NC1=C(NC(=O)C2=CC=C(CNC(=O)\\C=C\\C3=CC=CN=C3)C=C2)C=C(F)C=C1",2.182,3,3,6]
["S8615","Sodium dichloroacetate (DCA)","h3","L7100-11","in 10mM DMSO","Apoptosis related,Dehydrogenase,NKCC,ROS","Metabolism","Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.",150.92,"2156-56-1",{"v":30,"d":"30.00"},198.78,{"v":30,"d":"30.00"},198.78,"http://selleckchem.com/products/sodium-dichloroacetate-dca.html","C2HCl2O2.Na","sodium salt","Dichloroacetic acid, bichloroacetic acid, BCA","[Na]OC(=O)C(Cl)Cl",1.081,2,0,2]
["S8639","Diphenyleneiodonium chloride (DPI)","a4","L7100-11","in 10mM DMSO","NADPH-oxidase,NOS,ROS,TRP Channel","Immunology & Inflammation","Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).",314.55,"4673-26-1",{"v":13,"d":"13.00"},41.33,"<1","N/A","http://selleckchem.com/products/diphenyleneiodonium-chloride-dpi.html","C12H8I.Cl","chloride","N/A","[Cl-].[I+]1C2=CC=CC=C2C3=C1C=CC=C3",1.101,0,0,0]
["S8699","SNS-314 Mesylate","b4","L7100-11","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.",527.04,"1146618-41-8",{"v":100,"d":"100.00"},189.74,"<1","N/A","http://selleckchem.com/products/sns-314.html","C18H15ClN6OS2.CH4O3S","Mesylate","N/A","ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.953,4,3,6]
["S8736","Verinurad (RDEA3170)","c4","L7100-11","in 10mM DMSO","OAT","Transmembrane Transporters","Verinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter with an IC50 of 25 nM for inhibiting transport activity of human URAT1. It inhibits the related URAT1 homologs OAT4 and OAT1 with approximately 200-fold lower affinity compared to URAT1 with IC50 values of 5.9 µM and 4.6 µM, respectively.",348.42,"1352792-74-5",{"v":70,"d":"70.00"},200.91,"<1","N/A","http://selleckchem.com/products/verinurad-rdea3170.html","C20H16N2O2S","free base","N/A","CC(C)(SC1=C(C=NC=C1)C2=C3C=CC=CC3=C(C=C2)C#N)C(O)=O",3.804,2,0,4]
["S9063","Harringtonine","d4","L7100-11","in 10mM DMSO","Antiviral","Microbiology","Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.",531.59,"26833-85-2",{"v":10,"d":"10.00"},18.81,"N/A","N/A","https://www.selleckchem.com/products/harringtonine.html","C28H37NO9","free base","FH15975","COC(=O)CC(O)(CCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",1.961,7,0,10]
["S9132","Harpagide","e4","L7100-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.",364.35,"6926-08-5",{"v":72,"d":"72.00"},197.61,"N/A","N/A","https://www.selleckchem.com/products/harpagide.html","C15H24O10","free base","N/A","CC1(O)CC(O)C2(O)C=COC(OC3OC(CO)C(O)C(O)C3O)C12",-3.902,3,5,3]
["S9249","Securinine","f4","L7100-11","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.",217.26,"5610-40-2",{"v":44,"d":"44.00"},202.52,"N/A","N/A","https://www.selleckchem.com/products/securinine.html","C13H15NO2","free base","N/A","O=C1OC23CC(C=CC2=C1)N4CCCCC34",1.449,2,0,0]
["S9265","7-Epitaxol","g4","L7100-11","in 10mM DMSO","Others","Others","7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug.",853.91,"105454-04-4",{"v":100,"d":"100.00"},117.11,"N/A","N/A","https://www.selleckchem.com/products/7-epitaxol.html","C47H51NO14","free base/salt","7-Epipaclitaxel","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S9321","Topotecan","h4","L7100-11","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.",421.45,"123948-87-8",{"v":84,"d":"84.00"},199.31,"N/A","N/A","https://www.selleckchem.com/products/topotecan.html","C23H23N3O5","free base","NSC609699,Nogitecan,SKFS 104864A","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.577,4,1,3]
["S9463","Demecarium Bromide","a5","L7100-11","in 10mM DMSO","AChR","Neuronal Signaling","Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent.",716.59,"56-94-0",{"v":100,"d":"100.00"},139.55,{"v":-1,"d":"-1.00"},"N/A","N/A","C32H52Br2N4O4","Bromide","N/A","[Br-].[Br-].CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C",-0.615,4,0,17]
["S9507","(−)-Norepinephrine","b5","L7100-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.",169.18,"51-41-2",{"v":11,"d":"11.00"},65.02,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/norepinephrine.html","C8H11NO3","Free Base","Arterenol, Levarterenol, L-Noradrenaline","NCC(O)C1=CC(=C(O)C=C1)O",-0.059,0,4,2]
["S4421","Josamycin","c5","L7100-11","in 10mM DMSO","Antibiotics","Microbiology","Josamycin (EN-141, Kitasamycin A3, Leucomycin A3, Turimycin A5) is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.",827.99,"16846-24-5",{"v":100,"d":"100.00"},120.77,"<1","N/A","http://www.selleck.cn/products/josamycin.html","C42H69NO15","Free Base","EN-141, Kitasamycin A3, Leucomycin A3, Turimycin A5","COC1C(CC(=O)OC(C)C/C=C/C=C/C(O)C(C)CC(CC=O)C1OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(C2O)N(C)C)OC(C)=O",2.957,12,2,14]
["S6546","PD153035","d5","L7100-11","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM).",360.21,"153436-54-5",{"v":6,"d":"6.00"},16.66,"<1","N/A","http://www.selleck.cn/products/pd153035.html","C16H14BrN3O2","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=NC=N2)NC3=CC(=CC=C3)Br",4.193,4,1,4]
["S6589","Norethisterone Enanthate","e5","L7100-11","in 10mM DMSO","Others","Others","Norethisterone Enanthate (Norethindrone Enanthate) is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women.",410.59,"3836-23-5",{"v":82,"d":"82.00"},199.71,"<1","N/A","http://www.selleck.cn/products/norethisterone-enanthate.html","C27H38O3","Free Base","Norethindrone Enanthate","CCCCCCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4C3CCC12C)C#C",7.186,3,0,7]
["S6593","Methylprednisolone sodium succinate","f5","L7100-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methylprednisolone sodium succinate (U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium) is a corticosteroid medication that reduces inflammation.",496.53,"2375-03-3",{"v":99,"d":"99.00"},199.38,{"v":99,"d":"99.00"},199.38,"http://www.selleck.cn/products/methylprednisolone-sodium-succinate.html","C26H33NaO8","Sodium succinate","U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium","[Na+].CC1CC2C3CCC(O)(C(=O)COC(=O)CCC([O-])=O)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",0.262,4,1,7]
["S6619","ABT 702 dihydrochloride","g5","L7100-11","in 10mM DMSO","Adenosine Kinase","Neuronal Signaling","ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation.",536.25,"1188890-28-9",{"v":100,"d":"100.00"},186.48,"<1","N/A","http://www.selleck.cn/products/abt-702-dihydrochloride.html","C22H21BrCl2N6O","Dihydrochloride","N/A","Cl.Cl.NC1=C2C(=NC=N1)N=C(C=C2C3=CC(=CC=C3)Br)C4=CN=C(C=C4)N5CCOCC5",4.441,5,1,3]
["S6625","Temsavir (BMS-626529)","h5","L7100-11","in 10mM DMSO","HIV Protease","Microbiology","Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.",473.48,"701213-36-7",{"v":95,"d":"95.00"},200.64,"<1","N/A","http://www.selleck.cn/products/temsavir-bms-626529.html","C24H23N7O4","Free Base","N/A","COC1=CN=C([N]2C=NC(=N2)C)C3=C1C(=C[NH]3)C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5",1.174,7,1,5]
["S6626","Brequinar (DUP785)","a6","L7100-11","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.",375.37,"96187-53-0",{"v":37,"d":"37.00"},98.57,"<1","N/A","http://www.selleck.cn/products/brequinar.html","C23H15F2NO2","Free Base","NSC 368390","CC1=C(N=C2C=CC(=CC2=C1C(O)=O)F)C3=CC=C(C=C3)C4=C(F)C=CC=C4",6.008,2,0,3]
["S9015","Homoharringtonine (CGX-635)","b6","L7100-11","in 10mM DMSO","STAT","JAK/STAT","Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.",545.62,"26833-87-4",{"v":10,"d":"10.00"},18.33,"N/A","N/A","https://www.selleckchem.com/products/homoharringtonine.html","C29H39NO9","free Base","Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633","COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",2.418,7,0,11]
["S9110","Morin","c6","L7100-11","in 10mM DMSO","Others","Others","Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.",302.24,"480-16-0",{"v":10,"d":"10.00"},33.09,"N/A","N/A","https://www.selleckchem.com/products/morin.html","C15H10O7","free base","Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum","OC1=CC(=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S7654","Defactinib (VS-6063)","d6","L7100-11","in 10mM DMSO","FAK","Angiogenesis","Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.",510.49,"1073154-85-4",{"v":100,"d":"100.00"},{"v":195.8,"d":"195.80"},"<1","N/A","http://selleckchem.com/products/defactinib.html","C20H21F3N8O3S","free base","PF-04554878","CNC(=O)C1=CC=C(NC2=NC(=C(C=N2)C(F)(F)F)NCC3=C(N=CC=N3)N(C)[S](C)(=O)=O)C=C1",1.774,7,3,9]
["S1375","Dorzolamide HCl","a2","L7100-12","in 10mM Water","Carbonic Anhydrase","Metabolism","Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.",{"v":360.9,"d":"360.90"},"130693-82-2","<1","N/A",{"v":14,"d":"14.00"},38.79,"http://selleckchem.com/products/Dorzolamide-HCL.html","C10H16N2O4S3.HCl","Hydrochloride","MK-507 (L-671152) HCl","Cl.CCNC1CC(C)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",0.527,4,2,3]
["S1516","Cidofovir","b2","L7100-12","in 10mM Water","CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Cidofovir (HPMPC,Vistide,GS 0504) suppresses virus replication by selective inhibition of viral DNA synthesis.",279.19,"113852-37-2",{"v":2,"d":"2.00"},7.16,{"v":12,"d":"12.00"},42.98,"http://selleckchem.com/products/Cidofovir.html","C8H14N3O6P","Free Base","HPMPC,Vistide,GS 0504","NC1=NC(=O)N(CC(CO)OC[P](O)(O)=O)C=C1",-2.175,3,2,6]
["S1579","Palbociclib (PD0332991) Isethionate","c2","L7100-12","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",573.66,"827022-33-3","<1","N/A",{"v":10,"d":"10.00"},17.43,"http://selleckchem.com/products/pd-0332991-palbociclib-isethionate.html","C24H29N7O2.C2H6O4S","Isethionate","N/A","CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O.OCC[S](O)(=O)=O",1.847,5,3,7]
["S1853","Penicillamine","d2","L7100-12","in 10mM Water","Others","Others","Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease.",149.21,"52-67-5","<1","N/A",{"v":30,"d":"30.00"},201.06,"http://selleckchem.com/products/Penicillamine(Cuprimine).html","C5H11NO2S","free base","Dimethyl Cysteine","CC(C)(S)C(N)C(O)=O",-2.496,1,1,2]
["S2048","Clindamycin Phosphate","e2","L7100-12","in 10mM Water","Antibiotics","Microbiology","Clindamycin Phosphate (NSC 618653) is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM.",504.96,"24729-96-2","<1","N/A",{"v":101,"d":"101.00"},200.02,"http://selleckchem.com/products/clindamycin-phosphate.html","C18H34ClN2O8PS","free base","NSC 618653","CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O[P](O)(O)=O)C(O)C2O",1.205,3,3,9]
["S2129","Fudosteine","f2","L7100-12","in 10mM Water","Others","Metabolism","Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.",179.24,"13189-98-5","<1","N/A",{"v":36,"d":"36.00"},200.85,"http://selleckchem.com/products/Fudosteine.html","C6H13NO3S","free base","N/A","NC(CSCCCO)C(O)=O",-3.373,1,2,6]
["S2527","Methacycline HCl","g2","L7100-12","in 10mM Water","Antibiotics","Microbiology","Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.",478.88,"3963-95-9",{"v":3,"d":"3.00"},6.26,{"v":5,"d":"5.00"},10.44,"http://selleckchem.com/products/Methacycline-hydrochloride-Physiomycine.html","C22H22N2O8.HCl","Hydrochloride","Rondomycin","Cl.CN(C)C1C2C(O)C3C(=C)C4=CC=CC(=C4C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O)O",-0.565,3,5,2]
["S4127","Terbutaline Sulfate","h2","L7100-12","in 10mM Water","Adrenergic Receptor","GPCR & G Protein","Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.",548.65,"23031-32-5","<1","N/A",{"v":100,"d":"100.00"},182.27,"http://selleckchem.com/products/terbutaline-sulfate.html","C24H38N2O6.H2SO4","Sulfate","Terbutaline hemisulfate","CC(C)(C)NCC(O)C1=CC(=CC(=C1)O)O.CC(C)(C)NCC(O)C2=CC(=CC(=C2)O)O.O[S](O)(=O)=O",2.001,0,8,8]
["S4144","Amprolium HCl","a3","L7100-12","in 10mM Water","Vitamin","Metabolism","Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.",315.24,"137-88-2",{"v":2,"d":"2.00"},6.34,{"v":63,"d":"63.00"},199.85,"http://selleckchem.com/products/amprolium-hcl.html","C14H19N4.HCl.Cl","Hydrochloride","N/A","Cl.[Cl-].CCCC1=NC=C(C[N+]2=C(C)C=CC=C2)C(=N1)N",-0.036,2,1,4]
["S4236","Proflavine Hemisulfate","b3","L7100-12","in 10mM Water","Anti-infection,DNA/RNA Synthesis","Microbiology","Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.",258.25,"1811-28-5","<1","N/A",{"v":22,"d":"22.00"},85.19,"http://selleckchem.com/products/proflavine-hemisulfate.html","C13H11N3.1/2H2SO4","Sulfate","N/A","NC1=CC=C2C=C3C=CC(=CC3=NC2=C1)N.NC4=CC=C5C=C6C=CC(=CC6=NC5=C4)N.O[S](O)(=O)=O",3.113,2,4,0]
["S5097","Methotrexate disodium","c3","L7100-12","in 10mM Water","Dehydrogenase,DHFR","Metabolism","Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.",{"v":498.4,"d":"498.40"},"7413-34-5","<1","N/A",{"v":99,"d":"99.00"},198.64,"http://selleckchem.com/products/methotrexate-disodium.html","C20H20N8O5.2Na","disodium salt","N/A","[Na+].[Na+].CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O",-2.834,5,3,9]
["S5136","Calcium folinate","d3","L7100-12","in 10mM Water","DHFR","Metabolism","Calcium folinate (Leucovorin calcium, Folinic acid calcium salt, Wellcovorin) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.",{"v":511.5,"d":"511.50"},"1492-18-8","<1","N/A",{"v":100,"d":"100.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/calcium-folinate.html","C20H21N7O7.Ca","calcium salt","Leucovorin calcium, Folinic acid calcium salt, Wellcovorin","[Ca++].NC1=NC(=C2N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)CNC2=N1)O",{"v":0,"d":"0.000"},0,0,0]
["S5267","Nylidrin Hydrochloride","e3","L7100-12","in 10mM Water","Adrenergic Receptor","Neuronal Signaling","Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.",335.87,"849-55-8","N/A",{"v":0,"d":"0.00"},{"v":67,"d":"67.00"},199.48,"https://www.selleckchem.com/products/nylidrin-hydrochloride.html","C19H25NO2.HCl","hydrochloride","Buphenine HCl","Cl.CC(CCC1=CC=CC=C1)NC(C)C(O)C2=CC=C(O)C=C2",4.112,0,3,7]
["S5524","Spermine Tetrahydrochloride","f3","L7100-12","in 10mM Water","Others","Others","Spermine (Gerontine, Neuridine, Musculamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.",348.18,"306-67-2","<1","N/A",{"v":69,"d":"69.00"},198.17,"http://selleckchem.com/products/spermine-tetrahydrochloride.html","C10H26N4.4HCl","tetrahydrochloride","Gerontine tetrahydrochloride, Neuridine tetrahydrochloride, Musculamine tetrahydrochloride","Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN",0.024,0,4,11]
["S6023","Creatine monohydrate","g3","L7100-12","in 10mM Water","Others","Others","Creatine (Methylguanidoacetic acid) is a key player in the phosphagen energy system, the primary source of ATP during short-term, high intensity activities.",149.15,"6020-87-7","N/A","N/A",5.96,39.94,"http://www.selleck.cn/products/creatine-monohydrate.html","C4H11N3O3","monohydrate","Methylguanidoacetic acid monohydrate","O.CN(CC(O)=O)C(N)=N",-1.302,1,1,3]
["S7204","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","h3","L7100-12","in 10mM Water","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.",440.29,"168555-66-6","<1","N/A",{"v":28,"d":"28.00"},63.59,"http://selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html","C18H19O8P.2Na","Disodium salt","CA 4DP","[Na+].[Na+].COC1=C(O[P]([O-])([O-])=O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",1.077,5,0,8]
["S8501","Adaptavir (DAPTA)","a4","L7100-12","in 10mM Water","CCR","Immunology & Inflammation","Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.",856.88,"106362-34-9","N/A","N/A",{"v":100,"d":"100.00"},{"v":116.7,"d":"116.70"},"http://selleckchem.com/products/dapta.html","C35H56N10O15","free base","D-Ala-peptide T-amide, peptide T","CC(N)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(C(C)O)C(N)=O",-7.366,9,16,24]
["P1011","Eptifibatide Acetate","b4","L7100-12","in 10mM Water","5-alpha Reductase","Angiogenesis","Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.",{"v":832.4,"d":"832.40"},"148031-34-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/eptifibatide-acetate.html","C35H49N11O9S2","Acetate","Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2","NC(=N)NCCCCC1NC(=O)CCSSCC(NC(=O)C2CCCN2C(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC(=O)C(CC(O)=O)NC(=O)CNC1=O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["S3076","Foscarnet Sodium","c4","L7100-12","in 10mM Water","Reverse Transcriptase","Microbiology","Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.",191.95,"63585-09-1","N/A","N/A",{"v":3,"d":"3.00"},15.63,"http://selleckchem.com/products/foscarnet-sodium.html","CNa3O5P","Sodium","Phosphonoformate","[Na+].[Na+].[Na+].[O-]C(=O)[P]([O-])([O-])=O",-4.033,0,0,1]
["S1019","Canertinib (CI-1033)","a2","L7100-13","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Canertinib (CI-1033, PD183805) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.",485.94,"267243-28-7",{"v":2,"d":"2.00"},4.12,"<1","N/A","http://selleckchem.com/products/CI-1033(Canertinib).html","C24H25ClFN5O3","Free Base","PD183805","FC1=C(Cl)C=C(NC2=NC=NC3=CC(=C(NC(=O)C=C)C=C23)OCCCN4CCOCC4)C=C1",4.037,5,2,9]
["S1043","Tandutinib (MLN518)","b2","L7100-13","in 2mM DMSO","FLT3","Angiogenesis","Tandutinib (MLN518, CT53518, NSC726292) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.",{"v":562.7,"d":"562.70"},"387867-13-2",{"v":5,"d":"5.00"},8.89,"<1","N/A","http://selleckchem.com/products/Tandutinib-(MLN518).html","C31H42N6O4","Free Base","CT 53518, NSC726292, MLN518","COC1=CC2=C(C=C1OCCCN3CCCCC3)N=CN=C2N4CCN(CC4)C(=O)NC5=CC=C(OC(C)C)C=C5",4.674,6,1,10]
["S1046","Vandetanib (ZD6474)","c2","L7100-13","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1108","TAE684 (NVP-TAE684)","d2","L7100-13","in 2mM DMSO","ALK,Apoptosis related","Protein Tyrosine Kinase","TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.",{"v":614.2,"d":"614.20"},"761439-42-3",{"v":3,"d":"3.00"},4.88,"<1","N/A","http://selleckchem.com/products/NVP-TAE684.html","C30H40ClN7O3S","Free Base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.342,5,2,9]
["S1205","PIK-75 HCl","e2","L7100-13","in 2mM DMSO","DNA-PK,PI3K","PI3K/Akt/mTOR","PIK-75 HCl is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.",488.74,"372196-77-5",{"v":4,"d":"4.00"},8.18,"<1","N/A","http://selleckchem.com/products/PIK-75-Hydrochloride.html","C16H14BrN5O4S.HCl","Hydrochloride","N/A","Cl.CN(/N=C/C1=CN=C2C=CC(=C[N]12)Br)[S](=O)(=O)C3=C(C)C=CC(=C3)[N+]([O-])=O",3.272,4,0,5]
["S1211","Imiquimod (R-837)","f2","L7100-13","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Imiquimod (Aldara,R-837,S-26308) is a novel synthetic agent with immune response modifying activity.",{"v":240.3,"d":"240.30"},"99011-02-6",{"v":1,"d":"1.00"},4.16,"<1","N/A","http://selleckchem.com/products/Imiquimod.html","C14H16N4","free base","Aldara,R-837, S-26308","CC(C)C[N]1C=NC2=C(N)N=C3C=CC=CC3=C12",2.722,2,1,2]
["S1353","Ketoconazole (R 41400)","g2","L7100-13","in 2mM DMSO","Androgen Receptor,Fungal,P450 (e.g. CYP17)","Metabolism","Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.",531.43,"65277-42-1",{"v":5,"d":"5.00"},9.41,"<1","N/A","http://selleckchem.com/products/Ketoconazole.html","C26H28Cl2N4O4","free base","R 41400","CC(=O)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=CN=C4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",{"v":3.61,"d":"3.610"},5,0,7]
["S1509","Norfloxacin","h2","L7100-13","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Norfloxacin (MK-0366) is a broad-spectrum antibiotic. Norfloxacin (MK-0366) targets bacterial gyrase and topoisomerase IV enzymes.",319.33,"70458-96-7",{"v":3,"d":"3.00"},9.39,"<1","N/A","http://selleckchem.com/products/Norfloxacin(Norxacin).html","C16H18FN3O3","free base","MK-0366","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(C=C12)N3CCNCC3)F",{"v":0,"d":"0.000"},0,0,0]
["S1519","CCT129202","a3","L7100-13","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.",497.02,"942947-93-5",{"v":3,"d":"3.00"},6.04,"<1","N/A","http://selleckchem.com/products/CCT129202.html","C23H25ClN8OS","Free Base","N/A","CN(C)C1=CC=C(C=C1)C2=NC3=C(N4CCN(CC4)CC(=O)NC5=NC=CS5)C(=CN=C3[NH]2)Cl",2.898,4,2,6]
["S1642","Methyldopa","b3","L7100-13","in 2mM DMSO","5-HT Receptor,Adrenergic Receptor,Decarboxylase,Dopamine Receptor","Metabolism","Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.",211.21,"555-30-6",{"v":2,"d":"2.00"},9.47,"<1","N/A","http://selleckchem.com/products/Methyldopa(Aldomet).html","C10H13NO4","free base","N/A","CC(N)(CC1=CC(=C(O)C=C1)O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S1698","Torsemide","c3","L7100-13","in 2mM DMSO","Chloride Channel","Transmembrane Transporters","Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.",348.42,"56211-40-6",{"v":3,"d":"3.00"},8.61,"<1","N/A","http://selleckchem.com/products/Torsemide(Demadex).html","C16H20N4O3S","free base","AC-4464, JDL-464","CC(C)NC(=O)N[S](=O)(=O)C1=C(NC2=CC(=CC=C2)C)C=CN=C1",{"v":0,"d":"0.000"},0,0,0]
["S1707","Eplerenone (CGP 30083)","d3","L7100-13","in 2mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Eplerenone (CGP 30083, SC-66110) is a mineralocorticoid receptor antagonist, and blocks the action of aldosterone, used to control high blood pressure.",414.49,"107724-20-9",{"v":4,"d":"4.00"},9.65,"<1","N/A","http://selleckchem.com/products/Eplerenone(Inspra).html","C24H30O6","free base","CGP 30083, SC-66110","COC(=O)C1CC2=CC(=O)CCC2(C)C34OC3CC5(C)C(CCC56CCC(=O)O6)C14",{"v":0,"d":"0.000"},0,0,0]
["S1837","Flubendazole","e3","L7100-13","in 2mM DMSO","Autophagy,Parasite","Autophagy","Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.",313.28,"31430-15-6",{"v":3,"d":"3.00"},9.58,"<1","N/A","http://selleckchem.com/products/flubendazole-flutelmium.html","C16H12FN3O3","free base","Flumoxanal, NSC 313680","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)C(=O)C3=CC=C(F)C=C3",{"v":3.26,"d":"3.260"},4,2,4]
["S1851","Oxibendazole","f3","L7100-13","in 2mM DMSO","Parasite","Microbiology","Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.",249.27,"20559-55-1",{"v":1,"d":"1.00"},4.01,"<1","N/A","http://selleckchem.com/products/oxibendazole.html","C12H15N3O3","Free Base","N/A","CCCOC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",2.506,4,2,5]
["S1977","Sarafloxacin HCl","g3","L7100-13","in 2mM DMSO","Antibiotics","Microbiology","Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.",421.83,"91296-87-6",{"v":4,"d":"4.00"},9.48,"<1","N/A","http://selleckchem.com/products/sarafloxacin-hydrochloride.html","C20H17F2N3O3.HCl","Hydrochloride","A-56620 HCl","Cl.OC(=O)C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(=C3)N4CCNCC4)C1=O",{"v":0,"d":"0.000"},0,0,0]
["S1986","Meclizine 2HCl","h3","L7100-13","in 2mM DMSO","CAR,Histamine Receptor","Neuronal Signaling","Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.",463.87,"1104-22-9",{"v":4,"d":"4.00"},8.62,"<1","N/A","http://selleckchem.com/products/meclizine-dihydrochloride.html","C25H27Cl2N2.2HCl","Dihydrochloride","NSC 28728,Meclozine dihydrochloride","Cl.Cl.CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(Cl)C=C4",{"v":0,"d":"0.000"},0,0,0]
["S2150","Neratinib (HKI-272)","a4","L7100-13","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.",557.04,"698387-09-6",{"v":5,"d":"5.00"},8.98,"<1","N/A","http://selleckchem.com/products/Neratinib(HKI-272).html","C30H29ClN6O3","free base","N/A","CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(=C2NC3=CC=C(OCC4=NC=CC=C4)C(=C3)Cl)C#N",4.881,5,2,11]
["S2395","Rheochrysidin","b4","L7100-13","in 2mM DMSO","Anti-infection","Microbiology","Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.",284.26,"521-61-9",{"v":1,"d":"1.00"},3.52,"<1","N/A","http://selleckchem.com/products/Rheochrysidin-Physcione.html","C16H12O5","Free Base","Physcione","COC1=CC2=C(C(=C1)O)C(=O)C3=C(O)C=C(C)C=C3C2=O",2.794,3,2,1]
["S2476","Itraconazole (R 51211)","c4","L7100-13","in 2mM DMSO","Autophagy,Fungal,Hedgehog/Smoothened,P450 (e.g. CYP17)","Stem Cells & Wnt","Itraconazole (R 51211) is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.",705.65,"84625-61-6",{"v":7,"d":"7.00"},9.92,"<1","N/A","http://selleckchem.com/products/Itraconazole(Sporanox).html","C35H38Cl2N8O4","free base","R 51211","CCC(C)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C[N]6C=NC=N6)(O5)C7=CC=C(Cl)C=C7Cl)C=C4",6.434,7,0,11]
["S2530","7-Aminocephalosporanic acid","d4","L7100-13","in 2mM DMSO","Antibiotics","Microbiology","7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates.",272.28,"957-68-6",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/7-Aminocephalosporanic-acid.html","C10H12N2O5S","Free Base","N/A","CC(=O)OCC1=C(N2C(SC1)C(N)C2=O)C(O)=O",-3.745,4,1,4]
["S2597","Oseltamivir Phosphate","e4","L7100-13","in 2mM DMSO","Influenza Virus,Neuraminidase","Microbiology","Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.",{"v":410.4,"d":"410.40"},"204255-11-8",{"v":4,"d":"4.00"},9.75,"<1","N/A","http://selleckchem.com/products/oseltamivir-phosphate-Tamiflu.html","C16H28N2O4.H3PO4","Phosphate salt","Tamiflu","CCOC(=O)C1=CC(OC(CC)CC)C(NC(C)=O)C(N)C1.O[P](O)(O)=O",0.577,4,2,8]
["S2628","Gedatolisib (PKI-587)","f4","L7100-13","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.",615.73,"1197160-78-3",{"v":2,"d":"2.00"},3.25,"<1","N/A","http://selleckchem.com/products/pki587.html","C32H41N9O4","Free Base","PF-05212384","CN(C)C1CCN(CC1)C(=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C=C2",2.525,7,2,7]
["S2684","Pidnarulex (CX-5461)","g4","L7100-13","in 2mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.",513.61,"1138549-36-6",{"v":2,"d":"2.00"},3.89,"<1","N/A","http://www.selleck.cn/products/cx-5461.html","C27H27N7O2S","Free Base","N/A","CN1CCCN(CC1)C2=CC=C3C(=O)C(=C4SC5=C(C=CC=C5)N4C3=N2)C(=O)NCC6=CN=C(C)C=N6",3.188,5,1,4]
["S2704","LY2109761","h4","L7100-13","in 2mM DMSO","Apoptosis related,Autophagy,TGF-beta/Smad","TGF-beta/Smad","LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.",441.52,"700874-71-1",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/ly2109761.html","C26H27N5O2","Free Base","N/A","C1C[N]2N=C(C3=NC=CC=C3)C(=C2C1)C4=CC=NC5=C4C=CC(=C5)OCCN6CCOCC6",{"v":3.62,"d":"3.620"},5,0,6]
["S2735","MK-8776 (SCH 900776)","a5","L7100-13","in 2mM DMSO","CDK,Chk","Cell Cycle","MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.",376.25,"891494-63-6",{"v":3,"d":"3.00"},7.97,"<1","N/A","http://selleckchem.com/products/sch-900776.html","C15H18BrN7","Free Base","N/A","C[N]1C=C(C=N1)C2=C3N=C(C4CCCNC4)C(=C(N)[N]3N=C2)Br",{"v":1.32,"d":"1.320"},3,2,2]
["S2744","CCT137690","b5","L7100-13","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.",551.48,"1095382-05-0",{"v":4,"d":"4.00"},7.25,"<1","N/A","http://selleckchem.com/products/cct137690.html","C26H31BrN8O","Free Base","N/A","CN1CCN(CC1)C2=CC=C(C=C2)C3=NC4=C(N5CCN(CC5)CC6=NOC(=C6)C)C(=CN=C4[NH]3)Br",3.704,4,1,5]
["S2805","LY364947","c5","L7100-13","in 2mM DMSO","Casein Kinase,Mixed Lineage Kinase,RIP kinase,TGF-beta/Smad","TGF-beta/Smad","LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.",{"v":272.3,"d":"272.30"},"396129-53-6",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/ly364947.html","C17H12N4","Free Base","HTS 466284","[NH]1C=C(C2=C3C=CC=CC3=NC=C2)C(=N1)C4=NC=CC=C4",3.203,3,1,2]
["S2827","Torin 1","d5","L7100-13","in 2mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.",607.62,"1222998-36-8",{"v":2,"d":"2.00"},3.29,"<1","N/A","http://selleckchem.com/products/torin-1.html","C35H28F3N5O2","Free Base","N/A","CCC(=O)N1CCN(CC1)C2=CC=C(C=C2C(F)(F)F)N3C(=O)C=CC4=C3C5=CC(=CC=C5N=C4)C6=CC7=CC=CC=C7N=C6",5.914,4,0,5]
["S2870","TG100713","e5","L7100-13","in 2mM DMSO","PI3K","PI3K/Akt/mTOR","TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.",254.25,"925705-73-3",{"v":2,"d":"2.00"},7.87,"<1","N/A","http://selleckchem.com/products/tg-100713.html","C12H10N6","Free Base","N/A","NC1=NC(=C2N=C(C=NC2=N1)C3=CC(=CC=C3)O)N",0.982,4,3,1]
["S2920","Mozavaptan","f5","L7100-13","in 2mM DMSO","Vasopressin Receptor","GPCR & G Protein","Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.",427.54,"137975-06-5",{"v":1,"d":"1.00"},2.34,"<1","N/A","http://selleckchem.com/products/mozavaptan.html","C27H29N3O2","Free Base","OPC-31260","CN(C)C1CCCN(C(=O)C2=CC=C(NC(=O)C3=C(C)C=CC=C3)C=C2)C4=C1C=CC=C4",4.654,2,1,4]
["S3891","Vincamine","g5","L7100-13","in 2mM DMSO","Others","Others","Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.",354.44,"1617-90-9",{"v":3,"d":"3.00"},8.46,"N/A","N/A","http://selleckchem.com/products/vincamine.html","C21H26N2O3","free base","Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan","CCC12CCCN3CCC4=C(C13)[N](C5=CC=CC=C45)C(O)(C2)C(=O)OC",3.546,2,0,3]
["S4262","Ebastine","h5","L7100-13","in 2mM DMSO","Histamine Receptor","Neuronal Signaling","Ebastine(LAS-W 090,RP64305) is a potent H1-histamine receptor antagonist, used for allergic disorders.",469.66,"90729-43-4",{"v":4,"d":"4.00"},8.52,"<1","N/A","http://selleckchem.com/products/ebastine.html","C32H39NO2","free base","LAS-W 090,RP64305","CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4",6.582,2,0,10]
["S4642","Dolutegravir Sodium","a6","L7100-13","in 2mM DMSO","Integrase","Microbiology","Dolutegravir Sodium (GSK-1349572A) is a HIV integrase inhibitor with IC50 of 2.7 nM.",441.36,"1051375-19-9",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://www.selleck.cn/products/dolutegravir-sodium.html","C20H19F2N3O5.Na","Sodium","GSK-1349572A","CC1CCOC2CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(=C3C(=O)N12)O[Na]",0.391,5,1,4]
["S5232","Alectinib (CH5424802) hydrochloride","b6","L7100-13","in 2mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.",519.08,"1256589-74-8",{"v":2,"d":"2.00"},3.85,"<1","N/A","http://selleckchem.com/products/alectinib-hydrochloride.html","C30H34N4O2.HCl","hydrochloride","AF802, RO5424802, RG-7853","Cl.CCC1=C(C=C2C(=C1)C(=O)C3=C([NH]C4=C3C=CC(=C4)C#N)C2(C)C)N5CCC(CC5)N6CCOCC6",5.585,2,1,3]
["S7035","XL388","c6","L7100-13","in 2mM DMSO","mTOR","PI3K/Akt/mTOR","XL388 is a highly potent, selective, ATP-competitive inhibitor of  mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.",{"v":455.5,"d":"455.50"},"1251156-08-7",1.25,2.74,"<1","N/A","http://selleckchem.com/products/xl388.html","C23H22FN3O4S","free base","N/A","CC1=C(F)C(=CC=C1C(=O)N2CCOC3=CC=C(C=C3C2)C4=CN=C(N)C=C4)[S](C)(=O)=O",3.007,5,1,3]
["S7105","BAM7","d6","L7100-13","in 2mM DMSO","Bcl-2","Apoptosis","BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.",405.47,"331244-89-4",{"v":2,"d":"2.00"},4.93,"<1","N/A","http://selleckchem.com/products/bam7.html","C21H19N5O2S","Free Base","N/A","CCOC1=CC=CC=C1N\\N=C2/C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C",{"v":4.1,"d":"4.100"},5,1,6]
["S7128","Tazemetostat (EPZ-6438)","e6","L7100-13","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.",572.74,"1403254-99-8",{"v":5,"d":"5.00"},8.73,"<1","N/A","http://selleckchem.com/products/epz-6438.html","C34H44N4O4","free base","E7438","CCN(C1CCOCC1)C2=C(C)C(=CC(=C2)C3=CC=C(CN4CCOCC4)C=C3)C(=O)NCC5=C(C)C=C(C)NC5=O",3.506,4,2,9]
["S7342","UNC2250","f6","L7100-13","in 2mM DMSO","Mertk","Protein Tyrosine Kinase","UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.",440.58,"1493694-70-4",{"v":2,"d":"2.00"},4.54,"<1","N/A","http://selleckchem.com/products/unc2250.html","C24H36N6O2","Free Base","N/A","CCCCNC1=NC(=C(C=N1)C2=CC=C(CN3CCOCC3)C=N2)NC4CCC(O)CC4",3.236,4,3,9]
["S7518","Voreloxin (SNS-595) hydrochloride","g6","L7100-13","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.",{"v":437.9,"d":"437.90"},"175519-16-1",{"v":1,"d":"1.00"},2.28,{"v":1,"d":"1.00"},2.28,"http://selleckchem.com/products/voreloxin-sns-595.html","C18H20ClN5O4S","hydrochloride","Vosaroxin","Cl.CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(O)=O",-1.138,5,1,5]
["S8229","Brigatinib (AP26113)","h6","L7100-13","in 2mM DMSO","ALK,EGFR,FLT3,IGF-1R,ROS1","Angiogenesis","Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.",584.09,"1197953-54-0",{"v":3,"d":"3.00"},5.14,"<1","N/A","http://www.selleck.cn/products/brigatinib-ap26113.html","C29H39ClN7O2P","Free Base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)NC3=CC=CC=C3[P](C)(C)=O)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.084,6,2,8]
["S5098","Gefitinib hydrochloride","a7","L7100-13","in 2mM DMSO","EGFR","Protein Tyrosine Kinase","Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.",483.36,"184475-55-6","N/A",{"v":2,"d":"2.00"},{"v":1,"d":"1.00"},2.07,"http://selleckchem.com/products/gefitinib-hydrochloride.html","C22H24ClFN4O3.HCl","hydrochloride","ZD1839 hydrochloride","Cl.COC1=CC2=C(C=C1OCCCN3CCOCC3)C(=NC=N2)NC4=CC(=C(F)C=C4)Cl",4.585,5,1,8]
["S4226","Minocycline (CL 59806) HCl","a2","L7100-14","in 2mM Water","Antibiotics","Microbiology","Minocycline (CL 59806,Minocin) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.",493.94,"13614-98-7","<1","N/A",{"v":1,"d":"1.00"},2.02,"http://selleckchem.com/products/minocycline-hcl.html","C23H27N3O7.HCl","Hydrochloride","Minocin","Cl.CN(C)C1C2CC3CC4=C(C(=CC=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]