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[{"$nulls":3},"Autophagy Compound Library  (96-well)-L2600"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 1018 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L2600-01~12;    In 2 mM DMSO : Plate layout L2600-14"]
[{"$nulls":3},"In 10 mM Water: Plate layout L2600-13;     In 2 mM Water  : Plate layout L2600-15"]
[]
[]
[null,"Plate layout: L2600-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1002","S1014","S1029","S1041","S1057","S1071","S1084","S1102","S1117","S1138","Empty"]
[{"$nulls":3},"ABT-737","Bosutinib (SKI-606)","Lenalidomide (CC-5013)","STF-62247","Obatoclax Mesylate (GX15-070)","HA14-1","Brivanib (BMS-540215)","U0126-EtOH","Triciribine (NSC 154020)","Brivanib Alaninate (BMS-582664)"]
[null,"b","Empty","S1003","S1017","S1030","S1042","S1060","S1072","S1085","S1103","S1120","S1141","Empty"]
[{"$nulls":3},"Linifanib (ABT-869)","Cediranib (AZD2171)","Panobinostat (LBH589)","Sunitinib (SU11248) malate","Olaparib (AZD2281)","ZSTK474","Belinostat (PXD101)","ZM 447439","Everolimus (RAD001)","Tanespimycin (17-AAG)"]
[null,"c","Empty","S1004","S1020","S1033","S1044","S1061","S1075","S1089","S1104","S1122","S1144","Empty"]
[{"$nulls":3},"Veliparib (ABT-888)","PD184352 (CI-1040)","Nilotinib (AMN-107)","Temsirolimus (CCI-779)","Nutlin-3","SB216763","Refametinib (RDEA119)","GDC-0879","Mocetinostat (MGCD0103)","Ivacaftor (VX-770)"]
[null,"d","Empty","S1006","S1021","S1035","S1047","S1065","S1076","S1090","S1105","S1124","S1147","Empty"]
[{"$nulls":3},"Saracatinib (AZD0530)","Dasatinib (BMS-354825)","Pazopanib HCl (GW786034 HCl)","Vorinostat (SAHA)","Pictilisib (GDC-0941)","Adezmapimod (SB203580)","Abexinostat (PCI-24781)","LY294002","BMS-754807","Barasertib (AZD1152-HQPA)"]
[null,"e","Empty","S1007","S1022","S1036","S1048","S1066","S1077","S1092","S1106","S1129","S1148","Empty"]
[{"$nulls":3},"Roxadustat (FG-4592)","Ridaforolimus (Deforolimus, MK-8669)","Mirdametinib (PD0325901)","Tozasertib","SL-327","SB202190 (FHPI)","KU-55933 (ATM Kinase Inhibitor)","OSU-03012 (AR-12)","SRT1720 HCl","Docetaxel (RP56976)"]
[null,"f","Empty","S1008","S1025","S1038","S1049","S1068","S1078","S1095","S1107","S1130","S1150","Empty"]
[{"$nulls":3},"Selumetinib (AZD6244)","Gefitinib (ZD1839)","PI-103","Y-27632 2HCl","Crizotinib (PF-02341066)","MK-2206 2HCl","Dacinostat (LAQ824)","Danusertib (PHA-739358)","Sepantronium Bromide","Paclitaxel (NSC 125973)"]
[null,"g","Empty","S1011","S1026","S1039","S1053","S1069","S1080","S1096","S1109","S1133","S1152","Empty"]
[{"$nulls":3},"Afatinib (BIBW2992)","Imatinib (STI571) Mesylate","Rapamycin (AY-22989)","Entinostat (MS-275)","Luminespib (NVP-AUY922)","SU11274","Quisinostat (JNJ-26481585) 2HCl","BI 2536","Alisertib (MLN8237)","PLX-4720"]
[null,"h","Empty","S1013","S1028","S1040","S1055","S1070","S1082","S1100","S1113","S1134","S1154","Empty"]
[{"$nulls":3},"Bortezomib (PS-341)","Lapatinib (GW-572016) Ditosylate","Sorafenib (BAY 43-9006) tosylate","Enzastaurin (LY317615)","PHA-665752","Vismodegib (GDC-0449)","MLN8054","GSK690693","AT9283","SNS-314"]
[]
[]
[]
[null,"Plate layout: L2600-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1157","S1178","S1216","S1233","S1250","S1282","S1324","S1389","S1451","S1490","Empty"]
[{"$nulls":3},"Delanzomib (CEP-18770)","Regorafenib (BAY 73-4506)","PFI-1 (PF-6405761)","2-Methoxyestradiol (2-MeOE2)","Enzalutamide (MDV3100)","Artemisinin","Doxazosin Mesylate","Omeprazole","Aurora A Inhibitor I (TC-S 7010)","Ponatinib (AP24534)"]
[null,"b","Empty","S1165","S1181","S1218","S1234","S1251","S1290","S1333","S1391","S1454","S1515","Empty"]
[{"$nulls":3},"ABT-751 (E7010)","ENMD-2076","Clofarabine","AG-1024","Dienogest","Celastrol (NSC 70931)","Fluoxetine (Lilly 110140) HCl","Oxcarbazepine","PHA-680632","Pracinostat (SB939)"]
[null,"c","Empty","S1168","S1190","S1219","S1235","S1263","S1292","S1351","S1396","S1458","S1523","Empty"]
[{"$nulls":3},"Valproic Acid (NSC 93819) sodium salt","Bicalutamide (ICI-176334)","YM201636","Letrozole (CGS 20267)","Laduviglusib (CHIR-99021)","Chelerythrine Chloride (NSC 646662)","Ivermectin (MK-933)","Resveratrol (SRT501)","Neflamapimod (VX-745)","Voxtalisib (XL765) Analogue"]
[null,"d","Empty","S1169","S1191","S1225","S1237","S1266","S1293","S1352","S1398","S1460","S1526","Empty"]
[{"$nulls":3},"TGX-221","Fulvestrant (ICI-182780)","Etoposide (VP-16)","Temozolomide (CCRG 81045)","WYE-354","Cilnidipine (FRC-8653)","TG100-115","Stavudine (d4T)","SP600125","Quizartinib (AC220)"]
[null,"e","Empty","S1171","S1193","S1226","S1238","S1267","S1294","S1368","S1403","S1462","S1529","Empty"]
[{"$nulls":3},"CYC116","Thalidomide (K17)","KU-0063794","Tamoxifen (ICI 46474)","Vemurafenib (PLX4032)","Cilostazol (OPC-13013)","Acitretin","Tigecycline (GAR-936)","AZD6482","Hesperadin"]
[null,"f","Empty","S1172","S1194","S1227","S1241","S1274","S1304","S1369","S1422","S1475","S1530","Empty"]
[{"$nulls":3},"Serdemetan (JNJ-26854165)","CUDC-101","Raloxifene HCl","Vincristine (NSC-67574) sulfate","BX-795","Megestrol Acetate","Bafetinib (INNO-406)","Droxinostat","Pimasertib (AS-703026)","BIX 02188"]
[null,"g","Empty","S1175","S1204","S1230","S1245","S1275","S1305","S1378","S1425","S1484","S1531","Empty"]
[{"$nulls":3},"BIIB021","Melatonin (NSC 113928)","Flavopiridol (L86-8275)","Latrepirdine 2HCl","BX-912","Mercaptopurine (6-MP)","Ruxolitinib (INCB018424)","Ranolazine 2HCl","MC1568","BIX 02189"]
[null,"h","Empty","S1177","S1208","S1231","S1249","S1276","S1322","S1386","S1431","S1489","S1537","Empty"]
[{"$nulls":3},"PD98059","Doxorubicin (Adriamycin) HCl","Topotecan (NSC609699) HCl","JNJ-7706621","Adapalene","Dexamethasone (MK-125)","Nafamostat mesilate (FUT-175)","Sildenafil Citrate","PIK-93","Vadimezan (ASA404)"]
[]
[]
[]
[null,"Plate layout: L2600-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1541","S1573","S1627","S1689","S1744","S1792","S1840","S1915","S1990","S2060","Empty"]
[{"$nulls":3},"Selisistat (EX 527)","Fasudil (HA-1077) HCl","Nitazoxanide (NSC 697855)","Meprednisone","Nicotinic Acid","Simvastatin (MK 733)","Lomustine","Sulfamethoxazole","Capsaicin(Vanilloid)","Bromhexine HCl"]
[null,"b","Empty","S1555","S1574","S1635","S1693","S1747","S1794","S1847","S1916","S1994","S2061","Empty"]
[{"$nulls":3},"AZD8055","Doramapimod (BIRB 796)","Erythromycin","Carbamazepine","Nimodipine","Fenofibrate (NSC-281319)","Clemastine (HS-592) fumarate","Sulfisoxazole","Lacidipine","Lovastatin (MK-803)"]
[null,"c","Empty","S1556","S1576","S1638","S1703","S1759","S1802","S1848","S1937","S2007","S2077","Empty"]
[{"$nulls":3},"PHT-427","Sulfasalazine (NSC 667219)","Ibuprofen (NSC 256857)","Divalproex Sodium","Pitavastatin (NK-104) calcium","AICAR (Acadesine)","Curcumin","Isoniazid","Sulindac","Atorvastatin Calcium"]
[null,"d","Empty","S1558","S1582","S1647","S1714","S1762","S1805","S1885","S1950","S2012","S2080","Empty"]
[{"$nulls":3},"AT7867","H 89 2HCl","Adenosine","Gemcitabine (LY-188011)","Pyrazinamide","Acetylcholine Chloride","Felodipine","Metformin HCl","PCI-34051","Clevidipine Butyrate"]
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[{"$nulls":3},"Lumacaftor (VX-809)","TWS119","Tretinoin (NSC 122758)","Indomethacin (NSC-77541)","Sulfadiazine","Nifedipine (BAY-a-1040)","Hydroxyurea (NSC-32065)","Sulfamethizole","ENMD-2076 L-(+)-Tartaric acid","Dexmedetomidine HCl"]
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[{"$nulls":3},"Pomalidomide (CC-4047)","Reserpine","Ezetimibe (SCH-58235)","Methylprednisolone (NSC-19987)","Thioguanine (NSC 752)","Pranlukast","Amlodipine","Tamoxifen (ICI 46474) Citrate","Flunarizine 2HCl","Bexarotene (LGD1069)"]
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[{"$nulls":3},"PD318088","Clotrimazole","Isradipine","Meloxicam","Azacitidine (5-Azacytidine)","Carvedilol","Fluvastatin (XU-62-320) Sodium","Cyclocytidine HCl","Memantine HCl","Gabexate Mesylate"]
[null,"h","Empty","S1569","S1626","S1685","S1738","S1786","S1835","S1914","S1979","S2055","S2102","Empty"]
[{"$nulls":3},"Tazarotene","Naproxen Sodium","Sulfanilamide","Telmisartan","Verteporfin (CL 318952)","Azithromycin (CP-62993)","Pregnenolone","Amiodarone (NSC 85442) HCl","Gimeracil","Rasagiline Mesylate"]
[]
[]
[]
[null,"Plate layout: L2600-04"]
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[null,"a","Empty","S2111","S2170","S2218","S2244","S2266","S2295","S2314","S2348","S2399","S2437","Empty"]
[{"$nulls":3},"Lapatinib (GW-572016)","Givinostat (ITF2357)","Torkinib (PP242)","AR-42","Asiatic Acid","Emodin","Kaempferol (NSC 407289)","Rotenone (Barbasco)","Dihydromyricetin","Rotundine"]
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[{"$nulls":3},"Cisatracurium Besylate","Gandotinib (LY2784544)","Momelotinib (CYT387)","Buparlisib (BKM120)","Baicalin (NSC-661431)","Genistin (Genistoside)","Magnolol","Rutin","Rheic Acid","Tolbutamide (HLS 831)"]
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[{"$nulls":3},"Dronedarone HCl","Ixazomib (MLN2238)","SB590885","Silmitasertib (CX-4945)","Bergenin","Gossypol Acetate","Methyl-Hesperidin","Silibinin (NSC 651520)","Sodium Danshensu","Levosimendan"]
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[{"$nulls":3},"Atropine sulfate monohydrate","Ixazomib Citrate (MLN9708) Analogue","TAME","(-)-Epigallocatechin Gallate","Berberine chloride (NSC 646666)","Hesperetin","Myricetin","Taxifolin (Dihydroquercetin)","Isoliquiritigenin","Gambogic Acid"]
[null,"e","Empty","S2134","S2198","S2226","S2252","S2276","S2309","S2333","S2370","S2405","S2449","Empty"]
[{"$nulls":3},"AZD8330","SGI-1776 free base","Idelalisib","(+)-Usniacin","Bilobalide","Hesperidin","Nobiletin (NSC 76751)","Ursolic Acid","Sophocarpine","Colforsin"]
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[{"$nulls":3},"KW-2449","Aliskiren Hemifumarate","PIK-294","Aloe-emodin","Colchicine (NSC 757)","Honokiol (NSC 293100)","Oleanolic Acid","Biochanin A","Chrysophanic Acid","Bupivacaine HCl"]
[null,"g","Empty","S2161","S2215","S2238","S2261","S2285","S2312","S2341","S2391","S2412","S2456","Empty"]
[{"$nulls":3},"RAF265 (CHIR-265)","DAPT (GSI-IX)","Palomid 529 (P529)","Andrographolide","Cryptotanshinone","Icariin","(-)-Parthenolide","Quercetin (NSC 9221)","Genipin","Chlorpromazine HCl"]
[null,"h","Empty","S2163","S2217","S2243","S2262","S2290","S2313","S2347","S2396","S2425","S2458","Empty"]
[{"$nulls":3},"PF-4708671","Irinotecan (CPT-11) HCl Trihydrate","Degrasyn (WP1130)","Apigenin (LY 080400)","Dihydroartemisinin (DHA)","Indole-3-carbinol","Quercetin Dihydrate","Salidroside","Apocynin (NSC 2146)","Clonidine HCl"]
[]
[]
[]
[null,"Plate layout: L2600-05"]
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[{"$nulls":3},"Imatinib (STI571)","Sulfadoxine","Tetracaine HCl","Rabusertib (LY2603618)","PF-3845","A-769662","Crenolanib (CP-868596)","Fimepinostat (CUDC-907)","Daporinad","Tacedinaline (CI994)"]
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[{"$nulls":3},"Loperamide HCl","Maprotiline HCl","Tolvaptan","Tubastatin A HCl","AS-252424","CH5132799","Fedratinib (TG101348)","MK-5108 (VX-689)","Sirtinol","BI-D1870"]
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[{"$nulls":3},"Manidipine","Ciclopirox","Mifepristone (RU486)","Rebastinib (DCC-2036)","Trametinib (GSK1120212)","Geldanamycin (NSC 122750)","PAC-1","Nocodazole (R17934)","Dabrafenib (GSK2118436)","Carfilzomib (PR-171)"]
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[{"$nulls":3},"Manidipine 2HCl","5-Aminolevulinic acid HCl","Noradrenaline bitartrate monohydrate","CCT128930","Flavopiridol (L86-8275) HCl","TAK-901","GSK1070916","M344","Ipatasertib (GDC-0068)","GW5074"]
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[{"$nulls":3},"Nitrendipine","Daphnetin","TAK-733","SNX-2112 (PF-04928473)","WAY-600","AMG-900","PF-04691502","RITA (NSC 652287)","Sapanisertib (MLN0128)","IKK-16 (IKK Inhibitor VII)"]
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[{"$nulls":3},"Olanzapine","Rosiglitazone (BRL 49653)","PP121","WYE-125132 (WYE-132)","Turofexorate Isopropyl (XL335)","Nilvadipine","BGT226 (NVP-BGT226) maleate","Vistusertib (AZD2014)","Alpelisib (BYL719)","WZ811"]
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[{"$nulls":3},"Rosiglitazone (BRL-49653) maleate","Isoprenaline (NCI-C55630) HCl","OSI-027","Clinofibrate","Apitolisib (GDC-0980)","PH-797804","Milciclib (PHA-848125)","Lonafarnib (SCH66336)","Torin 2","BAY 11-7082"]
[]
[]
[]
[null,"Plate layout: L2600-06"]
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[{"$nulls":3},"Dapivirine (TMC120)","Pifithrin-μ","Niclosamide (BAY2353)","Dexamethasone Acetate","Berbamine dihydrochloride","2,3-Butanedione-2-monoxime","Schizandrol A","Methyl protocatechuate","Acetyl Resveratrol","Sitagliptin phosphate monohydrate"]
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[{"$nulls":3},"IOX2","Paroxetine HCl","Linagliptin (BI-1356)","Sulfamerazine","Cordycepin","Lumefantrine","Quercitrin","Kaempferide","Pterostilbene","Lithocholic acid"]
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[{"$nulls":3},"Salubrinal","Pazopanib","Vildagliptin (LAF-237)","Sodium salicylate","(+)-Fangchinoline","Sinomenine hydrochloride","Isoalantolactone","Arteether","Bisdemethoxycurcumin (BDMC)","Probenecid"]
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[{"$nulls":3},"Laduviglusib (CHIR-99021) HCl","Aspirin (NSC 27223)","Daunorubicin (RP 13057) HCl","Trifluoperazine 2HCl","3-Nitropropionic acid","Guggulsterone E&Z","Loganin","(-)-Arctigenin","3'-Hydroxypterostilbene","Spironolactone"]
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[{"$nulls":3},"TDZD-8","Cabazitaxel (XRP6258)","Pravastatin sodium","Moclobemide (Ro 111163)","Spermidine trihydrochloride","Lycorine hydrochloride","1-Deoxynojirimycin","Tetrahydrocurcumin","Pinocembrin","Sodium Nitroprusside Dihydrate"]
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[{"$nulls":3},"Apoptosis Activator 2","Lamotrigine","Rupatadine Fumarate","Schisandrin B (Sch B)","Fludrocortisone acetate","Scutellarin","Baohuoside I","(-)-epigallocatechin","Valproic acid (VPA)","Erythromycin Ethylsuccinate"]
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[{"$nulls":3},"TAK-715","PMSF","Azelnidipine","Betulinic acid","Glucosamine hydrochloride","Bakuchiol","Eupatilin","Ginsenoside Rb1","Tannic acid","Levobupivacaine HCl"]
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[{"$nulls":3},"Pifithrin-α (PFTα) HBr","Piceatannol","Sulfathiazole","Fangchinoline","Nortriptyline hydrochloride","Schisandrin A","Harmine","(-)-Epicatechin gallate","Nordihydroguaiaretic acid (NDGA)","Guanidine HCl"]
[]
[]
[]
[null,"Plate layout: L2600-07"]
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[{"$nulls":3},"Propranolol HCl","Cysteamine HCl","Dicoumarol","Salicylic acid","Clioquinol","3,3'-Diindolylmethane","Nicotinamide N-oxide","Azathramycin","Sitagliptin","Adenosine 5'-monophosphate monohydrate"]
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[{"$nulls":3},"Sulfacetamide Sodium","Mevastatin","Bromocriptine Mesylate","Triclosan","TTNPB (Arotinoid Acid)","Oxyresveratrol","Tenovin-6","TBHQ","Neferine","Urolithin A"]
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[{"$nulls":3},"Esmolol HCl","Cepharanthine","Pentoxifylline","Trimetazidine dihydrochloride","Diazoxide","Wogonin","JNK-IN-8","2-Aminobenzenesulfonamide","Naproxen","SC66"]
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[{"$nulls":3},"Sodium Phenylbutyrate","Bergapten","Mefloquine HCl","Xylitol","Isosorbide Mononitrate","(20S)-Protopanaxadiol","SN-38","Avermectin B1","GSK4112","Meisoindigo"]
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[{"$nulls":3},"Carprofen","Quinacrine 2HCl","Vinblastine (NSC-49842) sulfate","Danthron","Dantrolene sodium hemiheptahydrate","Citalopram HBr","b-AP15","Tacrolimus (FK506)","Fenretinide (NSC 374551)","FAAH-IN-2"]
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[{"$nulls":3},"Penfluridol","Tamibarotene","Acetazolamide","Sulfabenzamide","Efavirenz","Sulfacetamide sodium salt hydrate","Usnic acid","Pramipexole dihydrochloride","Cediranib Maleate","Pseudolaric Acid B"]
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[{"$nulls":3},"Sulfaguanidine","Vinorelbine ditartrate (KW-2307)","Aceglutamide","Succinylsulfathiazole","Esculetin","Ganoderic acid A","Skatole","Dabrafenib Mesylate","Ruxolitinib Phosphate","Erucic acid"]
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[{"$nulls":3},"Nicardipine HCl","Procainamide HCl","Pantoprazole sodium","Nitroxoline","(+)-Catechin","Benzyl isothiocyanate","Sulfalene (SMPZ)","Regorafenib (BAY-734506) Monohydrate","Dasatinib hydrochloride","Tizoxanide"]
[]
[]
[]
[null,"Plate layout: L2600-08"]
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[{"$nulls":3},"Metyrapone","Lanatoside C","Deferoxamine mesylate (Ba 33112)","acalisib (GS-9820)","fexaramine","AR7","GSK2656157","MK-8745","Zebularine (NSC 309132)","CFTRinh-172"]
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[{"$nulls":3},"Sofalcone","Thioridazine hydrochloride","Aliskiren","Monomyristin","Bicyclol","JZL195","PD168393","Tepotinib (EMD 1214063)","Tovorafenib (MLN2480)","TCID"]
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[{"$nulls":3},"Ferulic acid methyl ester","Triflupromazine hydrochloride","Sulforaphane","Cabergoline","Lucanthone","Binimetinib (MEK162)","Brefeldin A","GSK2334470","PYR-41","AZD1080"]
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[{"$nulls":3},"Sanguinarine chloride","Cytarabine hydrochloride","Dronedarone","GSK 5959","LX2343","LCL161","Oprozomib (ONX 0912)","Zotarolimus (ABT-578)","PR-619","DMH1"]
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[{"$nulls":3},"Isobavachalcone","Amsacrine hydrochloride","Cyclic Pifithrin-α hydrobromide","CA-5f","KN-92 phosphate","VS-5584 (SB2343)","AZ20","Taselisib (GDC 0032)","P5091 (P005091)","NSC 319726"]
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[{"$nulls":3},"Saikosaponin A","Omeprazole Sodium","CID 2011756","BIA 10-2474","GNE-477","CZC24832","CGI1746","AZD1208","P22077","C646"]
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[{"$nulls":3},"Dantrolene sodium","Ambroxol","Motesanib (AMG-706)","VX-702","Briciclib","Duvelisib (IPI-145)","Tezacaftor (VX-661)","AZD3463","IU1","10058-F4"]
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[{"$nulls":3},"Galangin","Atorvastatin","Kevetrin hydrochloride","Glucosamine","MTX-211","RG-7112","LY2090314","(+)-JQ1","LDN-57444","Mdivi-1"]
[]
[]
[]
[null,"Plate layout: L2600-09"]
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[{"$nulls":3},"UNC1999","Skepinone-L","ZCL278","IOWH032","4E1RCat","KN-62","YH239-EE","G-749","BRD4770","Pilaralisib (XL147)"]
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[{"$nulls":3},"Avutometinib","Losmapimod (GW856553X)","MS436","ERK5-IN-1","PTC-209","KN-93 Phosphate","Uprosertib (GSK2141795)","Piperlongumine","RBC8","Voxtalisib (XL765)"]
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[{"$nulls":3},"PF-543 hydrochloride","AZD2858","GSK2606414","IPI-3063","E-64","SB-3CT","JNK Inhibitor IX","GDC-0623","BQU57","OTS964"]
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[{"$nulls":3},"CID755673","Beta-Lapachone","BAY 87-2243","URMC-099","Pepstatin A","AR-A014418","VGX-1027","AT13148","PX-478 2HCl","MI-773 (SAR405838)"]
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[{"$nulls":3},"BIO","NMS-873","SF1670","HS-173","Sorafenib (BAY 43-9006)","NH125","Afuresertib (GSK2110183)","IM-12","PI-3065","SB225002"]
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[{"$nulls":3},"DBeQ","PFK15","WZ4003","GNE-0877","Anisomycin","ZLN005","FR 180204","LMK-235","SU9516","OTS514 hydrochloride"]
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[{"$nulls":3},"Idasanutlin (RG-7388)","TAK-632","HTH-01-015","GNE-9605","Ascomycin (FK520)","EHT 1864 2HCl","XMD8-92","LRRK2-IN-1","DTP3","Telaglenastat (CB-839)"]
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[{"$nulls":3},"Thiamet G","RG2833 (RGFP109)","EHop-016","4EGI-1","CGP 57380","DMOG","GNE-7915","Reversine","D 4476","Obeticholic Acid"]
[]
[]
[]
[null,"Plate layout: L2600-10"]
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[{"$nulls":3},"GSK2578215A","SBE 13 HCl","Pluripotin (SC1)","AT7519 HCl","Dibutyryl-cAMP (Bucladesine)","Kenpaullone","PLX7904","Ricolinostat (ACY-1215)","Necrostatin-1","Nutlin-3b"]
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[{"$nulls":3},"PF-4989216","Bikinin","SU6656","Afatinib (BIBW2992) Dimaleate","NVP-CGM097","DEL-22379","PLX8394","GSK2636771","GDC-0349","UNC0638"]
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[{"$nulls":3},"SP2509","PRIMA-1","Akti-1/2","MHY1485","SBI-0206965","Tiplaxtinin (PAI-039)","AZD8835","SMI-4a","Cobimetinib (GDC-0973)","NSC 405020"]
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[{"$nulls":3},"PIK-III","Eprenetapopt (APR-246)","Sunitinib (SU11248)","AMG319","Onatasertib (CC 223)","STF-31","SBC-115076","BIX 01294","Scriptaid","Bardoxolone Methyl"]
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[{"$nulls":3},"Salirasib","SB239063","Erlotinib (OSI-774)","Licochalcone A","Spautin-1","Nemiralisib","VPS34-IN1","Agerafenib (RXDX-105)","Dynasore","GlyH-101"]
[null,"f","Empty","S7686","S7743","S7793","S7843","S7891","S7948","S7998","S8019","S8048","S8106","Empty"]
[{"$nulls":3},"ML141","CCT196969","Purvalanol A","BI-847325","CC-115","MRT67307 HCl","Entrectinib (RXDX-101)","Capivasertib (AZD5363)","Venetoclax (ABT-199)","NSC59984"]
[null,"g","Empty","S7694","S7747","S7798","S7854","S7898","S7949","S7999","S8031","S8049","S8124","Empty"]
[{"$nulls":3},"AZD8186","Ro-3306","GNE-317","Ulixertinib (BVD-523)","GSK621","MRT68921 HCl","SKF96365","NSC 23766","Tubastatin A","BMS-582949"]
[null,"h","Empty","S7709","S7751","S7799","S7857","S7906","S7953","S8000","S8036","S8050","S8125","Empty"]
[{"$nulls":3},"VX-11e","VER155008","Pexmetinib (ARRY-614)","8-Bromo-cAMP","PFI-4","ETC-1002","Tenovin-1","Butein","ETP-46464","Pamapimod"]
[]
[]
[]
[null,"Plate layout: L2600-11"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S8132","S8194","S8302","S8355","S8490","S8596","S8706","S8793","S9041","S9115","Empty"]
[{"$nulls":3},"Deguelin","umbralisib (TGR-1202)","SR-12813","APS-2-79 HCl","Tanzisertib(CC-930)","Autophinib","UM-164","ULK-101","Corosolic acid","Wogonoside"]
[null,"b","Empty","S8149","S8201","S8303","S8369","S8493","S8597","S8728","S8795","S9043","S9118","Empty"]
[{"$nulls":3},"NSC348884","BI-78D3","Kobe0065","Lys05","PD-166866 (PD166866)","LYN-1604","PK11000","FDL169","6-Shogaol","Beta-Asarone"]
[null,"c","Empty","S8157","S8202","S8304","S8403","S8534","S8640","S8738","S8801","S9047","S9120","Empty"]
[{"$nulls":3},"GDC-0326","PF-06447475","Azoramide","MX69","Temuterkib (LY3214996)","Reparixin (Repertaxin)","Bimiralisib (PQR309)","CC-90003","Leonurine Hydrochloride","Scutellarein"]
[null,"d","Empty","S8163","S8222","S8309","S8426","S8560","S8654","S8744","S8803","S9068","S9126","Empty"]
[{"$nulls":3},"Paxalisib (GDC-0084)","AS1842856","ATI-2341","10074-G5","Seletalisib (UCB-5857)","ex229 (compound 991)","PHY34","MK-3903","Trillin","Schizandrol B"]
[null,"e","Empty","S8165","S8240","S8317","S8432","S8576","S8672","S8745","S8807","S9076","S9141","Empty"]
[{"$nulls":3},"Cucurbitacin B","SMER28","3BDO","Troglitazone (CS-045)","EAD1","Tenalisib (RP6530)","Naporafenib (LXH254)","PFK158","Typhaneoside","Berbamine"]
[null,"f","Empty","S8174","S8275","S8322","S8456","S8580","S8690","S8752","S8808","S9080","S9148","Empty"]
[{"$nulls":3},"VO-Ohpic trihydrate","Tomivosertib (eFT-508)","Samotolisib (LY3023414)","VPS34 inhibitor 1 (Compound 19)","COTI-2","RAF709","leniolisib (CDZ 173)","DC661","Anhydroicaritin","Peiminine"]
[null,"g","Empty","S8177","S8298","S8330","S8464","S8581","S8698","S8755","S8813","S9084","S9150","Empty"]
[{"$nulls":3},"BH3I-1","CZ415","Eganelisib (IPI-549)","Citarinostat (ACY-241)","Serabelisib (TAK-117)","GLPG1837","AZ304","LIT-927","Rhoifolin","Daurisoline"]
[null,"h","Empty","S8181","S8299","S8335","S8483","S8589","S8699","S8764","S9031","S9114","S9160","Empty"]
[{"$nulls":3},"SBI-0640756","HA15","PF-06409577","CBL0137 HCl","SF2523","SNS-314 Mesylate","IITZ-01","Gambogenic acid","Polyphyllin I","Ziyu-glycoside I"]
[]
[]
[]
[null,"Plate layout: L2600-12"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S9172","S9280","S9413","S6534","S8506","S6680","S6804","S0709","S6851","E1220","Empty"]
[{"$nulls":3},"Phellodendrine","Demethoxycurcumin","Yangonin","CZC-54252","Navarixin (SCH-527123)","L-779450","CX546","Tubastatin A TFA","RA-190","CBR-470-1"]
[null,"b","Empty","S9190","S9293","S9424","S6599","S8839","S8500","S6807","S0819","S6889","E1339","Empty"]
[{"$nulls":3},"Oroxin B","Isoliquiritin","Liensinine diperchlorate","KM11060","Borussertib","BAY1125976","TA-02","BL-918","Monomethyl Fumarate","HPPE"]
[null,"c","Empty","S9204","S9309","S9428","S6617","S9086","S8909","S7862","S2176","S7321","E2988","Empty"]
[{"$nulls":3},"Oroxylin A","Micheliolide","Brazilin","MSX-122","Dihydrocapsaicin","UBCS039","Rottlerin","Tenovin-3","FIPI","Sulfosuccinimidyl oleate sodium"]
[null,"d","Empty","S9221","S9310","S9431","S6620","S9102","S9044","S8784","S3224","S8929","E1318","Empty"]
[{"$nulls":3},"Ferulaldehyde","Isorhychophylline","Dehydrocorydalin","Danirixin (GSK1325756)","Magnolin","Ginsenoside F2","PQR620","Cinobufagin","GCN2iB","Mavorixafor"]
[null,"e","Empty","S9234","S9314","S9503","S6645","S9111","S2427","S8943","S3241","S9611","E1537","Empty"]
[{"$nulls":3},"Schaftoside","Atractylenolide II","Fraxetin","AZD5069","Isorhamnetin","Triglycidyl Isocyanurate (Teroxirone)","VLX600","Loureirin A","ABTL-0812","MMRi62"]
[null,"f","Empty","S9240","S9384","S9507","S6716","S2002","S5183","S8947","S6760","S9694","S4684","Empty"]
[{"$nulls":3},"Isofraxidin","Sophocarpine Monohydrate","(−)-Norepinephrine","NSC 185058","CZC-25146","PD 169316","SX-682","LM22B-10","MLi-2","Sildenafil"]
[null,"g","Empty","S9243","S9408","S2931","S6744","S2421","S6787","S0407","S6811","E0441","Empty","Empty"]
[{"$nulls":3},"Protosappanin B","Beta-Elemonic acid","Aurora Kinase Inhibitor III","Inauhzin","PF-04457845","KN-93","XCT790","Miransertib (ARQ-092)","NK-252"]
[null,"h","Empty","S9277","S9411","S2933","S6751","S6650","S6797","S0707","S6847","E1141","Empty","Empty"]
[{"$nulls":3},"Alisol A","Liensinine","AM580","Brevianamide F","EN6","QX77","Silmitasertib (CX-4945) sodium salt","ML-9 HCl","KI696"]
[]
[]
[]
[null,"Plate layout: L2600-13"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1037","S2420","S4157","S8651","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Perifosine (KRX-0401)","Aloperine","Chloroquine diphosphate","bpV (HOpic)"]
[null,"b","Empty","S1135","S2507","S4236","S4519","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Pemetrexed (LY-231514) disodium","Salbutamol Sulfate","Proflavine Hemisulfate","Citric acid trilithium salt tetrahydrate"]
[null,"c","Empty","S1149","S2879","S4430","S9665","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Gemcitabine (LY-188011) HCl","AMD3465 hexahydrobromide","Hydroxychloroquine Sulfate (NSC 4375)","Motixafortide (BL-8040)"]
[null,"d","Empty","S1494","S3013","S4741","S2542","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ralimetinib (LY2228820) dimesylate","Plerixafor (AMD3100) 8HCl","Danshensu","Phenformin (NSC-756501) HCl"]
[null,"e","Empty","S1648","S3056","S7306","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Cytarabine (U-19920A)","Miltefosine","Dorsomorphin (Compound C) 2HCl"]
[null,"f","Empty","S1893","S3753","S7548","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"D-glutamine","L-Leucine","Rilmenidine Phosphate"]
[null,"g","Empty","S1999","S4028","S7785","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Sodium butyrate","Dexamethasone Sodium Phosphate","Pemetrexed Disodium Hydrate"]
[null,"h","Empty","S2008","S4029","S7873","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Taurine","Colistin Sulfate","Disodium (R)-2-Hydroxyglutarate"]
[]
[]
[]
[null,"Plate layout: L2600-14"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1023","S1837","S2893","S7756","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Erlotinib (OSI-774) HCl","Flubendazole","NU7026","Indoximod (NLG-8189）"]
[null,"b","Empty","S1046","S2232","S3042","S7840","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)","Ketanserin","Purmorphamine","Dorsomorphin (Compound C)"]
[null,"c","Empty","S1118","S2476","S3064","S7842","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"XL147 analogue","Itraconazole (R 51211)","Ambroxol HCl","LY3009120"]
[null,"d","Empty","S1205","S2628","S3770","S8527","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"PIK-75 HCl","Gedatolisib (PKI-587)","Sodium Aescinate","ROC-325"]
[null,"e","Empty","S1211","S2704","S7035","S8274","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Imiquimod (R-837)","LY2109761","XL388","STO-609"]
[null,"f","Empty","S1360","S2744","S7105","E1345","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"GSK1059615","CCT137690","BAM7","HS148"]
[null,"g","Empty","S1424","S2805","S7164","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Prazosin HCl","LY364947","GSK343"]
[null,"h","Empty","S1519","S2827","S7400","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"CCT129202","Torin 1","ISRIB (trans-isomer)"]
[]
[]
[]
[null,"Plate layout: L2600-15"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1346","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Heparin sodium"]
[null,"b","Empty","S8030","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Plerixafor (AMD3100)"]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L2600-Autophagy-1018cpds ","index":1,"n_rows":1019,"n_cols":23,"rows_kept":1019}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1002","ABT-737","a2","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Mitophagy","Apoptosis","ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.",813.43,"852808-04-9",{"v":100,"d":"100.00"},122.94,"<1","N/A","http://selleckchem.com/products/ABT-737.html","C42H45ClN6O5S2","free base","N/A","CN(C)CCC(CSC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[S](=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=C(C=CC=C5)C6=CC=C(Cl)C=C6",8.198,3,2,16]
["S1003","Linifanib (ABT-869)","b2","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,CSF-1R,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.",375.41,"796967-16-3",{"v":75,"d":"75.00"},199.78,"<1","N/A","http://selleckchem.com/products/ABT-869.html","C21H18FN5O","free base","AL39324,RG3635","CC1=CC(=C(F)C=C1)NC(=O)NC2=CC=C(C=C2)C3=C4C(=N[NH]C4=CC=C3)N",4.169,2,4,3]
["S1004","Veliparib (ABT-888)","c2","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,PARP","DNA Damage/DNA Repair","Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.",244.29,"912444-00-9",{"v":17,"d":"17.00"},69.59,"<1","N/A","http://selleckchem.com/products/ABT-888.html","C13H16N4O","free base","NSC 737664","CC1(CCCN1)C2=NC3=C(C=CC=C3[NH]2)C(N)=O",0.986,2,3,2]
["S1006","Saracatinib (AZD0530)","d2","L2600-01","in 10mM DMSO","Autophagy,EGFR,Src","Angiogenesis","Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.",542.03,"379231-04-6",{"v":35,"d":"35.00"},64.57,"<1","N/A","http://selleckchem.com/products/AZD0530.html","C27H32ClN5O5","free base","N/A","CN1CCN(CCOC2=CC(=C3C(=NC=NC3=C2)NC4=C(Cl)C=CC5=C4OCO5)OC6CCOCC6)CC1",3.814,7,1,8]
["S1007","Roxadustat (FG-4592)","e2","L2600-01","in 10mM DMSO","Ferroptosis,HIF","Angiogenesis","Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.",352.34,"808118-40-3",{"v":70,"d":"70.00"},198.67,"<1","N/A","http://selleckchem.com/products/fg-4592.html","C19H16N2O5","free base","ASP1517","CC1=NC(=C(O)C2=C1C=C(OC3=CC=CC=C3)C=C2)C(=O)NCC(O)=O",2.306,4,2,5]
["S1008","Selumetinib (AZD6244)","f2","L2600-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It  also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.",457.68,"606143-52-6",{"v":91,"d":"91.00"},198.83,"<1","N/A","http://selleckchem.com/products/AZD6244.html","C17H15BrClFN4O3","free base","ARRY-142886","C[N]1C=NC2=C(F)C(=C(C=C12)C(=O)NOCCO)NC3=CC=C(Br)C=C3Cl",3.234,3,3,6]
["S1011","Afatinib (BIBW2992)","g2","L2600-01","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.",485.94,"850140-72-6",{"v":97,"d":"97.00"},199.61,"<1","N/A","http://selleckchem.com/products/BIBW2992.html","C24H25ClFN5O3","Free Base","BIBW2992","CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC=C(F)C(=C3)Cl)N=CN=C2C=C1OC4CCOC4",3.917,5,2,8]
["S1013","Bortezomib (PS-341)","h2","L2600-01","in 10mM DMSO","Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome","Proteases","Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.",384.24,"179324-69-7",{"v":76,"d":"76.00"},197.79,"<1","N/A","http://selleckchem.com/products/Bortezomib.html","C19H25BN4O4","Free Base","Velcade, LDP-341, MLM341, NSC 681239,PS-341","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O",2.183,4,2,9]
["S1014","Bosutinib (SKI-606)","a3","L2600-01","in 10mM DMSO","Autophagy,Bcr-Abl,ERK,S6 Kinase,Src,STAT","Angiogenesis","Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.",530.45,"380843-75-4",{"v":100,"d":"100.00"},188.52,"<1","N/A","http://selleckchem.com/products/Bosutinib.html","C26H29Cl2N5O3","free base","SKI-606","COC1=C(Cl)C=C(Cl)C(=C1)NC2=C(C=NC3=CC(=C(OC)C=C23)OCCCN4CCN(C)CC4)C#N",4.883,4,1,9]
["S1017","Cediranib (AZD2171)","b3","L2600-01","in 10mM DMSO","Autophagy,c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.",450.51,"288383-20-0",{"v":90,"d":"90.00"},199.77,"<1","N/A","http://selleckchem.com/products/Cediranib.html","C25H27FN4O3","free base","NSC-732208","COC1=C(OCCCN2CCCC2)C=C3N=CN=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.761,5,1,8]
["S1020","PD184352 (CI-1040)","c3","L2600-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis.",478.67,"212631-79-3",{"v":96,"d":"96.00"},200.56,"<1","N/A","http://selleckchem.com/products/CI-1040-(PD184352).html","C17H14ClF2IN2O2","free base","N/A","FC1=CC=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl",4.907,2,2,6]
["S1021","Dasatinib (BMS-354825)","d3","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.",488.01,"302962-49-8",{"v":98,"d":"98.00"},200.82,"<1","N/A","http://selleckchem.com/products/Dasatinib.html","C22H26ClN7O2S","free base","BMS-354825","CC1=NC(=CC(=N1)N2CCN(CCO)CC2)NC3=NC=C(S3)C(=O)NC4=C(Cl)C=CC=C4C",3.439,4,3,7]
["S1022","Ridaforolimus (Deforolimus, MK-8669)","e3","L2600-01","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.",990.21,"572924-54-0",{"v":198,"d":"198.00"},199.96,"<1","N/A","http://selleckchem.com/products/Deforolimus.html","C53H84NO14P","free base","AP23573","COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.303,12,1,8]
["S1025","Gefitinib (ZD1839)","f3","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,EGFR","Protein Tyrosine Kinase","Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.",{"v":446.9,"d":"446.90"},"184475-35-2",{"v":89,"d":"89.00"},199.15,"<1","N/A","http://selleckchem.com/products/Gefitinib.html","C22H24ClFN4O3","free base","Iressa,ZD1839","COC1=C(OCCCN2CCOCC2)C=C3C(=NC=NC3=C1)NC4=CC=C(F)C(=C4)Cl",4.203,5,1,8]
["S1026","Imatinib (STI571) Mesylate","g3","L2600-01","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.",589.71,"220127-57-1",{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Imatinib-Mesylate.html","C29H31N7O.CH4SO3","Mesylate","Gleevec, Glivec, CGP-57148B,STI571","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5.C[S](O)(=O)=O",3.806,4,2,7]
["S1028","Lapatinib (GW-572016) Ditosylate","h3","L2600-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.",925.46,"388082-77-7",{"v":100,"d":"100.00"},108.05,"<1","N/A","http://selleckchem.com/products/Lapatinib-Ditosylate.html","C29H26ClFN4O4S.2C7H8O3S","Ditosylat","GW-572016","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(=C7)F)C(=C6)Cl)C5=C4",9.339,6,2,13]
["S1029","Lenalidomide (CC-5013)","a4","L2600-01","in 10mM DMSO","Apoptosis related,Caspase,E3 Ligase ,E3 ligase Ligand,TNF-alpha,VEGFR","Ubiquitin","Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.",259.26,"191732-72-6",{"v":52,"d":"52.00"},200.57,"<1","N/A","https://www.selleckchem.com/products/lenalidomide-s1029.html","C13H13N3O3","free base","CC-5013","NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",-0.515,3,2,1]
["S1030","Panobinostat (LBH589)","b4","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC,HIV Protease","Epigenetics","Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.",349.43,"404950-80-7",{"v":69,"d":"69.00"},197.46,"<1","N/A","http://selleckchem.com/products/LBH-589.html","C21H23N3O2","Free Base","NVP-LBH589","CC1=C(CCNCC2=CC=C(\\C=C\\C(=O)NO)C=C2)C3=C([NH]1)C=CC=C3",3.194,1,3,7]
["S1033","Nilotinib (AMN-107)","c4","L2600-01","in 10mM DMSO","AMPK,Autophagy,Bcr-Abl","Angiogenesis","Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.",529.52,"641571-10-0",{"v":27,"d":"27.00"},50.99,"<1","N/A","http://selleckchem.com/products/Nilotinib.html","C28H22F3N7O","free base","AMN-107","CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CC=C5",5.084,5,2,7]
["S1035","Pazopanib HCl (GW786034 HCl)","d4","L2600-01","in 10mM DMSO","Autophagy,c-Kit,CSF-1R,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.",473.98,"635702-64-6",{"v":17,"d":"17.00"},35.87,"<1","N/A","http://selleckchem.com/products/Pazopanib-Hydrochloride.html","C21H23N7O2S.HCl","Hydrochloride","GW786034 HCl","Cl.C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",4.123,5,2,5]
["S1036","Mirdametinib (PD0325901)","e4","L2600-01","in 10mM DMSO","MEK","MAPK","Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.",482.19,"391210-10-9",{"v":96,"d":"96.00"},199.09,"<1","N/A","http://selleckchem.com/products/PD-0325901.html","C16H14F3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C=C1)F",2.578,2,4,7]
["S1038","PI-103","f4","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.",348.36,"371935-74-9",{"v":24,"d":"24.00"},68.89,"<1","N/A","http://selleckchem.com/products/PI-103.html","C19H16N4O3","free base","N/A","OC1=CC(=CC=C1)C2=NC3=C(OC4=C3C=CC=N4)C(=N2)N5CCOCC5",2.798,5,1,2]
["S1039","Rapamycin (AY-22989)","g4","L2600-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1","N/A","http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1040","Sorafenib (BAY 43-9006) tosylate","h4","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate)  is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",637.03,"475207-59-1",{"v":127,"d":"127.00"},199.36,0.01,0.02,"http://selleckchem.com/products/Sorafenib-Tosylate.html","C21H16ClF3N4O3.C7H8O3S","Tosylate","BAY 43-9006 tosylate,NSC-724772 tosylate","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O",5.824,4,3,7]
["S1041","STF-62247","a5","L2600-01","in 10mM DMSO","Autophagy","Autophagy","STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).",267.35,"315702-99-9",{"v":53,"d":"53.00"},198.24,"<1","N/A","http://selleckchem.com/products/STF-62247.html","C15H13N3S","free base","N/A","CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3",3.659,2,1,3]
["S1042","Sunitinib (SU11248) malate","b5","L2600-01","in 10mM DMSO","Apoptosis related,c-Kit,IRE1,Mitophagy,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.",532.56,"341031-54-7",{"v":15,"d":"15.00"},28.17,"<1","N/A","http://selleckchem.com/products/Sunitinib-Malate-(Sutent).html","C22H27FN4O2.C4H6O5","Malate","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=CC=C(F)C=C23.OC(CC(O)=O)C(O)=O",-1.049,4,4,10]
["S1044","Temsirolimus (CCI-779)","c5","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis.",1030.29,"162635-04-3",{"v":67,"d":"67.00"},65.03,"<1","N/A","http://selleckchem.com/products/Temsirolimus.html","C56H87NO16","free base","NSC 683864,CCI-779","COC1CC(CCC1OC(=O)C(C)(CO)CO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.039,12,3,11]
["S1047","Vorinostat (SAHA)","d5","L2600-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1","N/A","http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1048","Tozasertib","e5","L2600-01","in 10mM DMSO","Aurora Kinase,Autophagy,Bcr-Abl,FLT3","Cell Cycle","Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.",464.59,"639089-54-6",{"v":93,"d":"93.00"},200.18,"<1","N/A","http://selleckchem.com/products/VX-680(MK-0457).html","C23H28N8OS","free base","VX-680, MK-0457","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)SC4=CC=C(NC(=O)C5CC5)C=C4",4.445,4,3,7]
["S1049","Y-27632 2HCl","f5","L2600-01","in 10mM DMSO","Autophagy,ROCK","Cell Cycle","Y-27632 2HCl is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",320.26,"129830-38-2",{"v":64,"d":"64.00"},199.84,{"v":14,"d":"14.00"},43.71,"http://selleckchem.com/products/Y-27632.html","C14H21N3O.2HCl","Dihydrochloride","N/A","Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.871,2,2,3]
["S1053","Entinostat (MS-275)","g5","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.",376.41,"209783-80-2",{"v":75,"d":"75.00"},199.25,"<1","N/A","http://selleckchem.com/products/MS-275.html","C21H20N4O3","free base","SNDX-275","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC(=O)OCC3=CN=CC=C3)C=C2",2.071,4,3,7]
["S1055","Enzastaurin (LY317615)","h5","L2600-01","in 10mM DMSO","PKC","TGF-beta/Smad","Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.",515.61,"170364-57-5",{"v":30,"d":"30.00"},58.18,"<1","N/A","http://selleckchem.com/products/Enzastaurin.html","C32H29N5O2","free base","N/A","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](C5CCN(CC5)CC6=NC=CC=C6)C7=CC=CC=C47",{"v":4.32,"d":"4.320"},3,1,5]
["S1057","Obatoclax Mesylate (GX15-070)","a6","L2600-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1","N/A","http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","b6","L2600-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,"N/A","N/A","http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1061","Nutlin-3","c6","L2600-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1065","Pictilisib (GDC-0941)","d6","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,PI3K","PI3K/Akt/mTOR","Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.",513.64,"957054-30-7",{"v":44,"d":"44.00"},85.66,"<1","N/A","http://selleckchem.com/products/GDC-0941.html","C23H27N7O3S2","free base","RG7321","C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6",2.153,6,1,5]
["S1066","SL-327","e6","L2600-01","in 10mM DMSO","MEK","MAPK","SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.",335.35,"305350-87-2",{"v":67,"d":"67.00"},199.79,"<1","N/A","http://selleckchem.com/products/SL327.html","C16H12F3N3S","free base","N/A","NC(\\SC1=CC=C(N)C=C1)=C(C#N)/C2=C(C=CC=C2)C(F)(F)F",3.705,0,2,4]
["S1068","Crizotinib (PF-02341066)","f6","L2600-01","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",450.34,"877399-52-5",{"v":9,"d":"9.00"},19.98,"<1","N/A","http://selleckchem.com/products/PF-2341066.html","C21H22Cl2FN5O","free base","PF-02341066","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S1069","Luminespib (NVP-AUY922)","g6","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),IGF-1R","Cytoskeletal Signaling","Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.",465.54,"747412-49-3",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/NVP-AUY922.html","C26H31N3O5","free base","AUY-922, VER-52296","CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C",4.069,4,3,7]
["S1070","PHA-665752","h6","L2600-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays,  >50-fold selectivity for c-Met than RTKs or STKs.",641.61,"477575-56-7",{"v":128,"d":"128.00"},{"v":199.5,"d":"199.50"},"<1","N/A","http://selleckchem.com/products/PHA-665752.html","C32H34Cl2N4O4S","free base","N/A","CC1=C(C(=C([NH]1)/C=C/2C(=O)NC3=C2C=C(C=C3)[S](=O)(=O)CC4=C(Cl)C=CC=C4Cl)C)C(=O)N5CCCC5CN6CCCC6",5.689,4,2,7]
["S1071","HA14-1","a7","L2600-01","in 10mM DMSO","Bcl-2","Apoptosis","HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.",409.23,"65673-63-4",{"v":82,"d":"82.00"},200.38,"<1","N/A","http://selleckchem.com/products/HA14-1.html","C17H17BrN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Br",2.511,5,1,7]
["S1072","ZSTK474","b7","L2600-01","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2.",417.41,"475110-96-4",{"v":21,"d":"21.00"},50.31,"<1","N/A","http://selleckchem.com/products/ZSTK474.html","C19H21F2N7O2","free base","N/A","FC(F)C1=NC2=C(C=CC=C2)[N]1C3=NC(=NC(=N3)N4CCOCC4)N5CCOCC5",3.366,6,0,4]
["S1075","SB216763","c7","L2600-01","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.",371.22,"280744-09-4",{"v":23,"d":"23.00"},61.96,"<1","N/A","http://selleckchem.com/products/SB-216763.html","C19H12N2O2Cl2","free base","N/A","C[N]1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CC=C(Cl)C=C4Cl",4.391,2,1,2]
["S1076","Adezmapimod (SB203580)","d7","L2600-01","in 10mM DMSO","Mitophagy,p38 MAPK","MAPK","Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.",377.43,"152121-47-6",{"v":43,"d":"43.00"},113.93,"<1","N/A","http://selleckchem.com/products/SB-203580.html","C21H16FN3OS","Free Base","RWJ 64809, PB 203580","C[S](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",3.883,3,1,4]
["S1077","SB202190 (FHPI)","e7","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,p38 MAPK","MAPK","SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.",331.34,"152121-30-7",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/SB-202190.html","C20H14N3OF","free base","N/A","OC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",4.211,2,2,3]
["S1078","MK-2206 2HCl","f7","L2600-01","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.",480.39,"1032350-13-2",{"v":14,"d":"14.00"},29.14,"<1","N/A","http://selleckchem.com/products/MK-2206.html","C25H21N5O.2HCl","Dihydrochloride","N/A","Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6",4.183,3,2,3]
["S1080","SU11274","g7","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Met","Protein Tyrosine Kinase","SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest.",568.09,"658084-23-2",{"v":92,"d":"92.00"},161.95,"<1","N/A","http://selleckchem.com/products/SU11274.html","C28H30CIN5O4S","free base","PKI-SU11274","CN1CCN(CC1)C(=O)C2=C(C)[NH]C(=C2C)/C=C/3C(=O)NC4=C3C=C(C=C4)[S](=O)(=O)N(C)C5=CC(=CC=C5)Cl",3.477,4,2,5]
["S1082","Vismodegib (GDC-0449)","h7","L2600-01","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.",{"v":421.3,"d":"421.30"},"879085-55-9",{"v":84,"d":"84.00"},199.38,"<1","N/A","http://selleckchem.com/products/GDC-0449.html","C19H14Cl2N2O3S","free base","GDC-0449","C[S](=O)(=O)C1=CC=C(C(=C1)Cl)C(=O)NC2=CC(=C(Cl)C=C2)C3=NC=CC=C3",4.265,4,1,4]
["S1084","Brivanib (BMS-540215)","a8","L2600-01","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.",370.38,"649735-46-6",{"v":74,"d":"74.00"},199.79,"<1","N/A","http://selleckchem.com/products/Brivanib.html","C19H19FN4O3","free base","N/A","CC(O)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.481,4,2,5]
["S1085","Belinostat (PXD101)","b8","L2600-01","in 10mM DMSO","Autophagy,HDAC","Epigenetics","Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.",318.35,"866323-14-0",{"v":64,"d":"64.00"},201.04,"<1","N/A","http://selleckchem.com/products/Belinostat.html","C15H14N2O4S","free base","PXD101,NSC726630, PX-105684","ONC(=O)/C=C/C1=CC(=CC=C1)[S](=O)(=O)NC2=CC=CC=C2",{"v":1.8,"d":"1.800"},3,2,5]
["S1089","Refametinib (RDEA119)","c8","L2600-01","in 10mM DMSO","MEK","MAPK","Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.",572.34,"923032-37-5",{"v":100,"d":"100.00"},174.72,"<1","N/A","http://selleckchem.com/products/refametinib-rdea119-bay86-9766.html","C19H20F3IN2O5S","free base","Bay 86-9766","COC1=C(N[S](=O)(=O)C2(CC2)CC(O)CO)C(=C(F)C(=C1)F)NC3=CC=C(I)C=C3F",2.827,3,4,9]
["S1090","Abexinostat (PCI-24781)","d8","L2600-01","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.",397.42,"783355-60-2",{"v":80,"d":"80.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/PCI-24781.html","C21H23N3O5","free base","CRA-024781","CN(C)CC1=C(OC2=CC=CC=C12)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO",2.353,4,2,8]
["S1092","KU-55933 (ATM Kinase Inhibitor)","e8","L2600-01","in 10mM DMSO","ATM/ATR,Autophagy,ULK","DNA Damage/DNA Repair","KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.",395.49,"587871-26-9",{"v":33,"d":"33.00"},83.44,"<1","N/A","http://selleckchem.com/products/KU-55933.html","C21H17NO3S2","free base","N/A","O=C1C=C(OC(=C1)C2=CC=CC3=C2SC4=CC=CC=C4S3)N5CCOCC5",4.393,3,0,2]
["S1095","Dacinostat (LAQ824)","f8","L2600-01","in 10mM DMSO","HDAC,p21","Epigenetics","Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.",379.46,"404951-53-7",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/LAQ824(NVP-LAQ824).html","C22H25N3O3","free base","NVP-LAQ824","OCCN(CCC1=C[NH]C2=C1C=CC=C2)CC3=CC=C(\\C=C\\C(=O)NO)C=C3",3.045,1,3,9]
["S1096","Quisinostat (JNJ-26481585) 2HCl","g8","L2600-01","in 10mM DMSO","HDAC","Epigenetics","Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.",467.39,"875320-31-3",{"v":79,"d":"79.00"},169.02,"<1","N/A","http://selleckchem.com/products/JNJ-26481585.html","C21H28Cl2N6O2","Dihydrochloride","N/A","Cl.Cl.C[N]1C=C(CNCC2CCN(CC2)C3=NC=C(C=N3)C(=O)NO)C4=CC=CC=C14",2.749,3,2,6]
["S1100","MLN8054","h8","L2600-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.",476.86,"869363-13-3",{"v":95,"d":"95.00"},199.22,"<1","N/A","http://selleckchem.com/products/MLN8054.html","C25H15ClF2N4O2","free base","N/A","OC(=O)C1=CC=C(NC2=NC3=C(CN=C(C4=CC(=CC=C34)Cl)C5=C(F)C=CC=C5F)C=N2)C=C1",6.192,4,1,4]
["S1102","U0126-EtOH","a9","L2600-01","in 10mM DMSO","Antiviral,Autophagy,MEK,Mitophagy","MAPK","U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.",426.56,"1173097-76-1",{"v":85,"d":"85.00"},199.27,"<1","N/A","http://selleckchem.com/products/U0126.html","C18H16N6S2.C2H6O","Ethanolate","N/A","CCO.N\\C(SC1=CC=CC=C1N)=C(C#N)\\C(C#N)=C(N)/SC2=CC=CC=C2N",2.169,0,5,5]
["S1103","ZM 447439","b9","L2600-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.",513.59,"331771-20-1",{"v":103,"d":"103.00"},200.55,"<1","N/A","http://selleckchem.com/products/ZM-447439.html","C29H31N5O4","free base","N/A","COC1=C(OCCCN2CCOCC2)C=C3N=CN=C(NC4=CC=C(NC(=O)C5=CC=CC=C5)C=C4)C3=C1",4.118,6,2,10]
["S1104","GDC-0879","c9","L2600-01","in 10mM DMSO","Raf","MAPK","GDC-0879 (AR-00341677) is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well; no inhibition known to other protein kinases.",334.37,"905281-76-7",{"v":66,"d":"66.00"},197.39,"<1","N/A","http://selleckchem.com/products/GDC-0879.html","C19H18N4O2","free base","AR-00341677","OCC[N]1C=C(C2=CC=C\\3C(=C2)CCC3=N\\O)C(=N1)C4=CC=NC=C4",2.387,3,1,4]
["S1105","LY294002","d9","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase,DNA-PK,PI3K","PI3K/Akt/mTOR","LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.",307.34,"154447-36-6",{"v":36,"d":"36.00"},117.13,"<1","N/A","http://selleckchem.com/products/LY294002.html","C19H17NO3","free base","SF 1101, NSC 697286","O=C1C=C(OC2=C(C=CC=C12)C3=CC=CC=C3)N4CCOCC4",3.342,3,0,2]
["S1106","OSU-03012 (AR-12)","e9","L2600-01","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.",460.45,"742112-33-0",{"v":11,"d":"11.00"},23.89,"<1","N/A","http://selleckchem.com/products/OSU-03012.html","C26H19F3N4O","free base","N/A","NCC(=O)NC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC4=C(C=C3)C5=C(C=CC=C5)C=C4)C(F)(F)F",5.212,2,2,5]
["S1107","Danusertib (PHA-739358)","f9","L2600-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,Bcr-Abl,c-RET,FGFR,Trk receptor","Cell Cycle","Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.",474.55,"827318-97-8",{"v":95,"d":"95.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHA-739358(Danusertib).html","C26H30N6O3","free base","N/A","COC(C(=O)N1CC2=C(C1)C(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CCN(C)CC4)C5=CC=CC=C5",2.337,4,2,6]
["S1109","BI 2536","g9","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Myc,PLK","Cell Cycle","BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.",521.66,"755038-02-9",{"v":21,"d":"21.00"},40.26,"<1","N/A","http://selleckchem.com/products/BI-2536.html","C28H39N7O3","free base","N/A","CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5",3.548,5,2,7]
["S1113","GSK690693","h9","L2600-01","in 10mM DMSO","Akt,AMPK,Autophagy,DAPK,PKA,PKC,STING,ULK","PI3K/Akt/mTOR","GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.",425.48,"937174-76-0",{"v":39,"d":"39.00"},91.66,"<1","N/A","http://selleckchem.com/products/GSK690693.html","C21H27N7O3","free base","N/A","CC[N]1C(=NC2=C1C(=CN=C2C#CC(C)(C)O)OCC3CCCNC3)C4=NON=C4N",1.839,6,2,7]
["S1117","Triciribine (NSC 154020)","a10","L2600-01","in 10mM DMSO","Akt,DNA/RNA Synthesis,HIV","PI3K/Akt/mTOR","Triciribine (NSC 154020, VD-0002, vqd-002, API-2, TCN) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.",{"v":320.3,"d":"320.30"},"35943-35-2",{"v":64,"d":"64.00"},199.81,"<1","N/A","http://selleckchem.com/products/Triciribine.html","C13H16N6O4","free base","VD-0002, vqd-002, API-2, TCN","CN1N=C(N)C2=C[N](C3OC(CO)C(O)C3O)C4=C2C1=NC=N4",-1.119,4,4,2]
["S1120","Everolimus (RAD001)","b10","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1","N/A","http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1122","Mocetinostat (MGCD0103)","c10","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.",396.44,"726169-73-9",{"v":13,"d":"13.00"},32.79,"<1","N/A","http://selleckchem.com/products/MGCD0103(Mocetinostat).html","C23H20N6O","free base","MG0103","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC3=NC=CC(=N3)C4=CC=CN=C4)C=C2",2.798,4,3,6]
["S1124","BMS-754807","d10","L2600-01","in 10mM DMSO","c-Met,IGF-1R,RON,Trk receptor","Protein Tyrosine Kinase","BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.",461.49,"1001350-96-4",{"v":92,"d":"92.00"},199.35,"<1","N/A","http://selleckchem.com/products/BMS-754807.html","C23H24FN9O","free base","N/A","CC1(CCCN1C2=N[N]3C=CC=C3C(=N2)NC4=N[NH]C(=C4)C5CC5)C(=O)NC6=CC=C(F)N=C6",4.069,5,3,6]
["S1129","SRT1720 HCl","e10","L2600-01","in 10mM DMSO","Autophagy,Sirtuin","Epigenetics","SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.",506.02,"1001645-58-4",{"v":38,"d":"38.00"},{"v":75.1,"d":"75.10"},"<1","N/A","http://selleckchem.com/products/SRT1720.html","C25H23N7OS.HCl","Hydrochloride","N/A","Cl.O=C(NC1=CC=CC=C1C2=C[N]3C(=CSC3=N2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5",3.018,4,2,5]
["S1130","Sepantronium Bromide","f10","L2600-01","in 10mM DMSO","Autophagy,IAP,Survivin","Apoptosis","Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.",443.29,"781661-94-7",{"v":55,"d":"55.00"},124.07,{"v":89,"d":"89.00"},200.77,"http://selleckchem.com/products/YM155.html","C20H19BrN4O3","Bromide","YM155","[Br-].COCC[N]1C(=[N+](CC2=CN=CC=N2)C3=C1C(=O)C4=C(C=CC=C4)C3=O)C",-0.733,5,0,5]
["S1133","Alisertib (MLN8237)","g10","L2600-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy","Cell Cycle","Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.",518.92,"1028486-01-2",{"v":27,"d":"27.00"},52.03,"<1","N/A","http://selleckchem.com/products/MLN8237.html","C27H20ClFN4O4","free base","N/A","COC1=C(C(=CC=C1)F)C2=NCC3=C(N=C(NC4=CC(=C(C=C4)C(O)=O)OC)N=C3)C5=C2C=C(Cl)C=C5",5.954,6,1,6]
["S1134","AT9283","h10","L2600-01","in 10mM DMSO","Aurora Kinase,Bcr-Abl,JAK","JAK/STAT","AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I).",381.43,"896466-04-9",{"v":76,"d":"76.00"},199.25,"<1","N/A","http://selleckchem.com/products/AT9283.html","C19H23N7O2","free base","N/A","O=C(NC1CC1)NC2=C[NH]N=C2C3=NC4=CC(=CC=C4[NH]3)CN5CCOCC5",{"v":1.51,"d":"1.510"},4,4,5]
["S1138","Brivanib Alaninate (BMS-582664)","a11","L2600-01","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.",441.46,"649735-63-7",{"v":88,"d":"88.00"},199.34,"<1","N/A","http://selleckchem.com/products/Brivanib-alaninate.html","C22H24FN5O4","Alaninate","N/A","CC(N)C(=O)OC(C)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.383,6,2,8]
["S1141","Tanespimycin (17-AAG)","b11","L2600-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),Mitophagy","Cytoskeletal Signaling","Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.",585.69,"75747-14-7",{"v":100,"d":"100.00"},170.74,"<1","N/A","http://selleckchem.com/products/17-AAG(Geldanamycin).html","C31H43N3O8","free base","CP127374, NSC-330507, KOS 953","COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.524,7,4,7]
["S1144","Ivacaftor (VX-770)","c11","L2600-01","in 10mM DMSO","CFTR","Transmembrane Transporters","Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.",392.49,"873054-44-5",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/VX-770.html","C24H28N2O3","free base","VX-770","CC(C)(C)C1=CC(=C(NC(=O)C2=CNC3=C(C=CC=C3)C2=O)C=C1O)C(C)(C)C",4.516,2,3,4]
["S1147","Barasertib (AZD1152-HQPA)","d11","L2600-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.",507.56,"722544-51-6",{"v":102,"d":"102.00"},200.96,"<1","N/A","http://selleckchem.com/products/AZD1152-HQPA.html","C26H30FN7O3","free base","AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib","CCN(CCO)CCCOC1=CC=C2C(=NC=NC2=C1)NC3=CC(=N[NH]3)CC(=O)NC4=CC=CC(=C4)F",3.493,5,4,13]
["S1148","Docetaxel (RP56976)","e11","L2600-01","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",807.88,"114977-28-5",{"v":100,"d":"100.00"},123.78,"<1","N/A","http://selleckchem.com/products/Docetaxel(Taxotere).html","C43H53NO14","Free Base","NSC 628503,RP56976","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",2.586,10,4,13]
["S1150","Paclitaxel (NSC 125973)","f11","L2600-01","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.",853.91,"33069-62-4",{"v":171,"d":"171.00"},200.26,"<1","N/A","http://selleckchem.com/products/Paclitaxel(Taxol).html","C47H51NO14","free base","PTX, Taxol, Onxal, Abraxane,NSC 125973","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S1152","PLX-4720","g11","L2600-01","in 10mM DMSO","Raf","MAPK","PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.",413.83,"918505-84-7",{"v":83,"d":"83.00"},200.57,"<1","N/A","http://selleckchem.com/products/PLX-4720.html","C17H14ClF2N3O3S","free base","N/A","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(Cl)C=C23",3.435,4,2,6]
["S1154","SNS-314","h11","L2600-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.",430.93,"1057249-41-8",{"v":105,"d":"105.00"},243.66,{"v":6,"d":"6.00"},13.92,"http://selleckchem.com/products/sns-314-mesylate.html","C18H15ClN6OS2","Mesylate","N/A","C[S](O)(=O)=O.ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.539,4,3,6]
["S1157","Delanzomib (CEP-18770)","a2","L2600-02","in 10mM DMSO","Proteasome","Proteases","Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2.",413.28,"847499-27-8",{"v":83,"d":"83.00"},200.83,"<1","N/A","http://selleckchem.com/products/cep-18770.html","C21H28BN3O5","free base","N/A","CC(C)C(CNC(=O)C(NC(=O)C1=NC(=CC=C1)C2=CC=CC=C2)C(C)O)B(O)O",2.646,3,3,9]
["S1165","ABT-751 (E7010)","b2","L2600-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.",371.41,"141430-65-1",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/ABT-751.html","C18H17N3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(NC3=CC=C(O)C=C3)N=CC=C2",2.997,4,3,6]
["S1168","Valproic Acid (NSC 93819) sodium salt","c2","L2600-02","in 10mM DMSO","Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1α","Neuronal Signaling","Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.",166.19,"1069-66-5",{"v":33,"d":"33.00"},198.57,{"v":33,"d":"33.00"},198.57,"http://selleckchem.com/products/Sodium-valproate.html","C8H15NaO2","Sodium salt","Sodium valproate,NSC 93819,2-Propylpentanoic Acid","CCCC(CCC)C(=O)O[Na]",1.275,0,0,5]
["S1169","TGX-221","d2","L2600-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, 1000-fold more selective for p110β than p110α.",364.44,"663619-89-4",{"v":12,"d":"12.00"},32.93,"<1","N/A","http://selleckchem.com/products/TGX-221.html","C21H24N4O2","free base","N/A","CC(NC1=CC=CC=C1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.373,3,1,4]
["S1171","CYC116","e2","L2600-02","in 10mM DMSO","Aurora Kinase,VEGFR","Cell Cycle","CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.",368.46,"693228-63-6",{"v":24,"d":"24.00"},65.14,"<1","N/A","http://selleckchem.com/products/CYC116.html","C18H20N6OS","free base","N/A","CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.743,4,2,4]
["S1172","Serdemetan (JNJ-26854165)","f2","L2600-02","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1175","BIIB021","g2","L2600-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.",318.76,"848695-25-0",{"v":64,"d":"64.00"},200.78,"<1","N/A","http://selleckchem.com/products/BIIB021.html","C14H15ClN6O","free base","CNF2024","COC1=C(C)C=NC(=C1C)C[N]2C=NC3=C(Cl)N=C(N)N=C23",2.223,5,1,3]
["S1177","PD98059","h2","L2600-02","in 10mM DMSO","AhR,MEK","MAPK","PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.",267.28,"167869-21-8",{"v":14,"d":"14.00"},52.38,"<1","N/A","http://selleckchem.com/products/PD-98059.html","C16H13NO3","free base","N/A","COC1=C(N)C(=CC=C1)C2=CC(=O)C3=CC=CC=C3O2",2.373,3,1,2]
["S1178","Regorafenib (BAY 73-4506)","a3","L2600-02","in 10mM DMSO","Autophagy,c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY 73-4506,Fluoro-Sorafenib, Resihance, Stivarga) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.",482.82,"755037-03-7",{"v":97,"d":"97.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://selleckchem.com/products/BAY-73-4506.html","C21H15ClF4N4O3","free base","Fluoro-Sorafenib, Resihance, Stivarga,BAY 73-4506","CNC(=O)C1=CC(=CC=N1)OC2=CC(=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)F",4.381,4,3,6]
["S1181","ENMD-2076","b3","L2600-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,CSF-1R,FGFR,FLT3,PDGFR,Src,VEGFR","Angiogenesis","ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.",375.47,"934353-76-1",{"v":105,"d":"105.00"},279.65,{"v":1,"d":"1.00"},2.66,"http://selleckchem.com/products/enmd-2076.html","C21H25N7","Tartaric Acid","N/A","CN1CCN(CC1)C2=CC(=NC(=N2)\\C=C\\C3=CC=CC=C3)NC4=N[NH]C(=C4)C",4.015,3,2,5]
["S1190","Bicalutamide (ICI-176334)","c3","L2600-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.",430.37,"90357-06-5",{"v":86,"d":"86.00"},199.83,"<1","N/A","http://selleckchem.com/products/Bicalutamide(Casodex).html","C18H14F4N2O4S","free base","ICI-176334","CC(O)(C[S](=O)(=O)C1=CC=C(F)C=C1)C(=O)NC2=CC=C(C#N)C(=C2)C(F)(F)F",2.926,3,1,6]
["S1191","Fulvestrant (ICI-182780)","d3","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor","Endocrinology & Hormones","Fulvestrant (ICI-182780, ZD 9238, ZM 182780) is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity.",606.77,"129453-61-8",{"v":100,"d":"100.00"},164.81,"<1","N/A","http://selleckchem.com/products/Fulvestrant.html","C32H47F5O3S","free base","ICI-182780, ZD 9238, ZM 182780","CC12CCC3C(C(CCCCCCCCC[S](=O)CCCC(F)(F)C(F)(F)F)CC4=C3C=CC(=C4)O)C1CCC2O",8.437,1,2,15]
["S1193","Thalidomide (K17)","e3","L2600-02","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.",258.23,"50-35-1",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Thalidomide.html","C13H10N2O4","free base","K17","O=C1CCC(N2C(=O)C3=C(C=CC=C3)C2=O)C(=O)N1",0.097,4,1,1]
["S1194","CUDC-101","f3","L2600-02","in 10mM DMSO","EGFR,HDAC,HER2","Epigenetics","CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.",434.49,"1012054-59-9",{"v":20,"d":"20.00"},46.03,"<1","N/A","http://selleckchem.com/products/CUDC-101.html","C24H26N4O4","free base","N/A","COC1=CC2=C(C=C1OCCCCCCC(=O)NO)C(=NC=N2)NC3=CC(=CC=C3)C#C",5.376,5,2,11]
["S1204","Melatonin (NSC 113928)","g3","L2600-02","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1","N/A","http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1208","Doxorubicin (Adriamycin) HCl","h3","L2600-02","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1216","PFI-1 (PF-6405761)","a4","L2600-02","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-1 (PF-6405761) is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.",347.39,"1403764-72-6",{"v":69,"d":"69.00"},198.62,"<1","N/A","http://selleckchem.com/products/pfl-1.html","C16H17N3O4S","free base","N/A","COC1=C(C=CC=C1)[S](=O)(=O)NC2=CC=C3NC(=O)N(C)CC3=C2",1.376,4,2,4]
["S1218","Clofarabine","b4","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.",303.68,"123318-82-1",{"v":60,"d":"60.00"},197.58,"<1","N/A","http://selleckchem.com/products/Clofarabine.html","C10H11ClFN5O3","free base","Clolar","NC1=C2N=C[N](C3OC(CO)C(O)C3F)C2=NC(=N1)Cl",-0.085,4,3,2]
["S1219","YM201636","c4","L2600-02","in 10mM DMSO","Autophagy,PI3K,PIKfyve","PI3K/Akt/mTOR","YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue). YM-201636 suppresses the growth of liver cancer via the induction of autophagy.",467.48,"371942-69-7",{"v":35,"d":"35.00"},74.87,"<1","N/A","http://selleckchem.com/products/ym201636.html","C25H21N7O3","free base","N/A","NC1=CC=C(C=N1)C(=O)NC2=CC=CC(=C2)C3=NC(=C4OC5=NC=CC=C5C4=N3)N6CCOCC6",2.467,7,2,4]
["S1225","Etoposide (VP-16)","d4","L2600-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II  inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.",588.56,"33419-42-0",{"v":100,"d":"100.00"},169.91,"<1","N/A","http://selleckchem.com/products/Etopophos.html","C29H32O13","free base","VP-16213,Vepesid,VP-16","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)C6=C2C=C7OCOC7=C6",0.935,10,3,5]
["S1226","KU-0063794","e4","L2600-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.",465.54,"938440-64-3",{"v":16,"d":"16.00"},34.37,"<1","N/A","http://selleckchem.com/products/KU-0063794.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=NC(=NC(=C3C=C2)N4CCOCC4)N5CC(C)OC(C)C5",3.274,6,1,5]
["S1227","Raloxifene HCl","f4","L2600-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (LY156758, Keoxifene) HCl is a selective and orally active estrogen receptor modulator (SERM), which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.",510.04,"82640-04-8",{"v":100,"d":"100.00"},196.06,"<1","N/A","http://selleckchem.com/products/Evista.html","C28H27NO4S.HCl","Hydrochloride","LY156758 (Keoxifene) HCl","Cl.OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.843,2,2,7]
["S1230","Flavopiridol (L86-8275)","g4","L2600-02","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.",401.84,"146426-40-6",{"v":15,"d":"15.00"},37.33,"<1","N/A","http://selleckchem.com/products/Flavopiridol.html","C21H20ClNO5","Free Base","NSC 649890 HCl, HMR-1275, Alvocidib","CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",3.108,2,3,2]
["S1231","Topotecan (NSC609699) HCl","h4","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,Topoisomerase","DNA Damage/DNA Repair","Topotecan HCl (Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.",457.91,"119413-54-6",{"v":91,"d":"91.00"},198.73,{"v":91,"d":"91.00"},198.73,"http://selleckchem.com/products/Topotecan-Hydrochloride.html","C23H23N3O5.HCl","Hydrochloride","Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.959,4,1,3]
["S1233","2-Methoxyestradiol (2-MeOE2)","a5","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,HIF,Microtubule Associated","Angiogenesis","2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.",302.41,"362-07-2",{"v":60,"d":"60.00"},198.41,"<1","N/A","http://selleckchem.com/products/2-Methoxyestradiol(2ME2).html","C19H26O3","free base","NSC 659853, 2-ME2","COC1=C(O)C=C2CCC3C(CCC4(C)C(O)CCC34)C2=C1",3.821,1,2,1]
["S1234","AG-1024","b5","L2600-02","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","AG-1024 (Tyrphostin, AGS 200) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).",305.17,"65678-07-1",{"v":61,"d":"61.00"},199.89,"<1","N/A","http://selleckchem.com/products/ag-1024-tyrphostin.html","C14H13BrN2O","free base","Tyrphostin, AGS 200","CC(C)(C)C1=C(O)C(=CC(=C1)C=C(C#N)C#N)Br",3.922,0,1,2]
["S1235","Letrozole (CGS 20267)","c5","L2600-02","in 10mM DMSO","Aromatase,Autophagy","Endocrinology & Hormones","Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.",{"v":285.3,"d":"285.30"},"112809-51-5",{"v":57,"d":"57.00"},199.79,"<1","N/A","http://selleckchem.com/products/Letrozole.html","C17H11N5","free base","CGS 20267,Femara, Piroxicam","N#CC1=CC=C(C=C1)C([N]2C=NC=N2)C3=CC=C(C=C3)C#N",2.749,2,0,3]
["S1237","Temozolomide (CCRG 81045)","d5","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.",194.15,"85622-93-1",{"v":38,"d":"38.00"},195.72,"<1","N/A","http://selleckchem.com/products/Methazolastone.html","C6H6N6O2","free base","NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal","CN1N=NC2=C(N=C[N]2C1=O)C(N)=O",0.052,5,1,1]
["S1238","Tamoxifen (ICI 46474)","e5","L2600-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,ATPase,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Angiogenesis","Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.",371.51,"10540-29-1",{"v":74,"d":"74.00"},199.19,"<1","N/A","http://selleckchem.com/products/Nolvadex.html","C26H29NO","Free Base","ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1241","Vincristine (NSC-67574) sulfate","f5","L2600-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.",923.04,"2068-78-2",{"v":100,"d":"100.00"},108.34,{"v":60,"d":"60.00"},{"v":65,"d":"65.00"},"http://selleckchem.com/products/Vincristine-Sulfate.html","C46H58N4O14S","free base","Leurocristine, Oncovin, NSC-67574, 22-Oxovincaleukoblastine","CCC1(O)CC2CN(CCC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=CC6=C(C=C5OC)N(C=O)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC67C89)C(=O)OC)C1.O[S](O)(=O)=O",3.365,8,1,10]
["S1245","Latrepirdine 2HCl","g5","L2600-02","in 10mM DMSO","5-HT Receptor,GluR,Histamine Receptor","Neuronal Signaling","Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.",392.37,"97657-92-6",{"v":24,"d":"24.00"},61.17,"<1","N/A","http://selleckchem.com/products/Dimebon.html","C21H25N3.2HCl","Dihydrochloride","N/A","Cl.Cl.CN1CCC2=C(C1)C3=C(C=CC(=C3)C)[N]2CCC4=CC=C(C)N=C4",4.769,1,0,3]
["S1249","JNJ-7706621","h5","L2600-02","in 10mM DMSO","Aurora Kinase,CDK","Cell Cycle","JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.",394.36,"443797-96-4",{"v":79,"d":"79.00"},200.32,"<1","N/A","http://selleckchem.com/products/JNJ-7706621.html","C15H12F2N6O3S","free base","N/A","NC1=NC(=N[N]1C(=O)C2=C(F)C=CC=C2F)NC3=CC=C(C=C3)[S](N)(=O)=O",2.226,5,3,4]
["S1250","Enzalutamide (MDV3100)","a6","L2600-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. Enzalutamide is shown to increase autophagy.",464.44,"915087-33-1",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/MDV3100.html","C21H16F4N4O2S","free base","MDV3100","CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC=C(C#N)C(=C3)C(F)(F)F",4.954,2,1,4]
["S1251","Dienogest","b6","L2600-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.",311.42,"65928-58-7",{"v":62,"d":"62.00"},199.09,"<1","N/A","http://selleckchem.com/products/Dienogest.html","C20H25NO2","free base","STS 557","CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC#N",3.046,1,0,1]
["S1263","Laduviglusib (CHIR-99021)","c6","L2600-02","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.",465.34,"252917-06-9",{"v":10,"d":"10.00"},21.49,"<1","N/A","http://selleckchem.com/products/CHIR-99021.html","C22H18Cl2N8","free base","CT99021","CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=CC=C(C=N3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.476,4,3,7]
["S1266","WYE-354","d6","L2600-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",495.53,"1062169-56-5",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/WYE-354.html","C24H29N7O5","free base","N/A","COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5",1.886,8,1,6]
["S1267","Vemurafenib (PLX4032)","e6","L2600-02","in 10mM DMSO","Autophagy,Raf","MAPK","Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.",489.92,"918504-65-1",{"v":97,"d":"97.00"},197.99,"<1","N/A","http://selleckchem.com/products/PLX-4032.html","C23H18ClF2N3O3S","free base","RG7204, RO5185426,PLX4032","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CC=C(Cl)C=C4",4.953,4,2,7]
["S1274","BX-795","f6","L2600-02","in 10mM DMSO","Autophagy,IκB/IKK,PDPK1,TBK1","PI3K/Akt/mTOR","BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.",591.47,"702675-74-9",{"v":100,"d":"100.00"},169.07,"<1","N/A","http://selleckchem.com/products/bx-795.html","C23H26IN7O2S","free base","N/A","IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4",3.704,4,4,9]
["S1275","BX-912","g6","L2600-02","in 10mM DMSO","PDK","PI3K/Akt/mTOR","BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.",471.35,"702674-56-4",{"v":94,"d":"94.00"},199.43,"<1","N/A","http://selleckchem.com/products/bx-912.html","C20H23BrN8O","free base","N/A","BrC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCC4=CN=C[NH]4",2.798,4,4,7]
["S1276","Adapalene","h6","L2600-02","in 10mM DMSO","Retinoid Receptor","Metabolism","Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.",412.52,"106685-40-9",{"v":8,"d":"8.00"},19.39,"<1","N/A","http://selleckchem.com/products/Adapalene.html","C28H28O3","free base","CD-271","COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(O)=O)[C]45CC6[CH2][CH](C[CH]([CH2]6)C4)C5",6.279,2,0,4]
["S1282","Artemisinin","a7","L2600-02","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.",282.33,"63968-64-9",{"v":57,"d":"57.00"},201.89,"<1","N/A","http://selleckchem.com/products/Artemisinin.html","C15H22O5","free base","Qinghaosu,Artemisinine,Coartem,NSC 369397","CC1CCC2C(C)C(=O)OC3OC4(C)CCC1C23OO4",1.998,5,0,0]
["S1290","Celastrol (NSC 70931)","b7","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1292","Chelerythrine Chloride (NSC 646662)","c7","L2600-02","in 10mM DMSO","PKC","TGF-beta/Smad","Chelerythrine Chloride (NSC 646662, Broussonpapyrine) is a potent, selective antagonist of PKC with IC50 of 0.66 μM.",384.83,"3895-92-9",{"v":4,"d":"4.00"},10.39,"<1","N/A","http://www.selleck.cn/products/Chelerythrine-chloride.html","C21H18NO4.HCl","Chloride","Broussonpapyrine chloride","Cl.COC1=CC=C2C(=C1OC)C=[N+](C)C3=C2C=CC4=C3C=C5OCOC5=C4",4.568,4,0,2]
["S1293","Cilnidipine (FRC-8653)","d7","L2600-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cilnidipine (FRC-8653) is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.",492.52,"132203-70-4",{"v":99,"d":"99.00"},201.01,"<1","N/A","http://selleckchem.com/products/Cilnidipine.html","C27H28N2O7","free base","FRC-8653","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC\\C=C\\C3=CC=CC=C3)C",3.686,5,1,12]
["S1294","Cilostazol (OPC-13013)","e7","L2600-02","in 10mM DMSO","PDE","Metabolism","Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.",369.46,"73963-72-1",{"v":74,"d":"74.00"},200.29,"<1","N/A","http://selleckchem.com/products/Cilostazol.html","C20H27N5O2","free base","Pletal,OPC-13013","O=C1CCC2=C(N1)C=CC(=C2)OCCCCC3=NN=N[N]3C4CCCCC4",{"v":3.23,"d":"3.230"},5,1,7]
["S1304","Megestrol Acetate","f7","L2600-02","in 10mM DMSO","Androgen Receptor,Estrogen/progestogen Receptor","Endocrinology & Hormones","Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.",384.51,"595-33-5",{"v":33,"d":"33.00"},85.82,"<1","N/A","http://selleckchem.com/products/Megestrol-Acetate.html","C24H32O4","free base","BDH1298, SC10363","CC(=O)OC1(CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C)C(C)=O",3.505,4,0,3]
["S1305","Mercaptopurine (6-MP)","g7","L2600-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",152.18,"50-44-2",{"v":30,"d":"30.00"},197.13,"<1","N/A","http://selleckchem.com/products/Mercaptopurine.html","C5H4N4S","free base","6-MP","S=C1N=CNC2=C1[NH]C=N2",0.367,2,2,0]
["S1322","Dexamethasone (MK-125)","h7","L2600-02","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1324","Doxazosin Mesylate","a8","L2600-02","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.",547.58,"77883-43-3",{"v":15,"d":"15.00"},27.39,"<1","N/A","http://selleckchem.com/products/Doxazosin-mesylate.html","C23H25N5O5.CH4O3S","Mesylate","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCN(CC3)C(=O)C4COC5=C(O4)C=CC=C5)N.C[S](O)(=O)=O",2.071,7,1,4]
["S1333","Fluoxetine (Lilly 110140) HCl","b8","L2600-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.",345.79,"56296-78-7",{"v":69,"d":"69.00"},199.54,{"v":4,"d":"4.00"},11.57,"http://selleckchem.com/products/Fluoxetine-hydrochloride.html","C17H18F3NO.HCl","Hydrochloride","Prozac, Sarafem,LY-110140","Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2",4.415,1,1,7]
["S1351","Ivermectin (MK-933)","c8","L2600-02","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1","N/A","http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1352","TG100-115","d8","L2600-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.",346.34,"677297-51-7",{"v":9,"d":"9.00"},25.99,"<1","N/A","http://selleckchem.com/products/TG100-115.html","C18H14N6O2","free base","N/A","NC1=NC2=NC(=C(N=C2C(=N1)N)C3=CC(=CC=C3)O)C4=CC=CC(=C4)O",2.687,4,4,2]
["S1368","Acitretin","e8","L2600-02","in 10mM DMSO","Retinoid Receptor","Metabolism","Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.",326.43,"55079-83-9",{"v":20,"d":"20.00"},61.27,"<1","N/A","http://selleckchem.com/products/Acitretin.html","C21H26O3","free base","Etretin, RO 10-1670","COC1=CC(=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(=C1C)C)C",5.665,2,0,6]
["S1369","Bafetinib (INNO-406)","f8","L2600-02","in 10mM DMSO","Bcr-Abl","Angiogenesis","Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.",576.62,"859212-16-1",{"v":100,"d":"100.00"},173.42,"<1","N/A","http://selleckchem.com/products/Bafetinib.html","C30H31F3N8O","free base","NS-187","CN(C)C1CCN(C1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CN=C5",4.197,5,2,9]
["S1378","Ruxolitinib (INCB018424)","g8","L2600-02","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",306.37,"941678-49-5",{"v":61,"d":"61.00"},199.11,"<1","N/A","http://selleckchem.com/products/INCB18424.html","C17H18N6","free base","INCB018424","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S1386","Nafamostat mesilate (FUT-175)","h8","L2600-02","in 10mM DMSO","Apoptosis related,COVID-19,SARS-CoV,Serine Protease","Proteases","Nafamostat mesilate (Futhan, FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.",539.58,"82956-11-4",{"v":20,"d":"20.00"},37.07,{"v":53,"d":"53.00"},98.22,"http://selleckchem.com/products/Nafamostat-mesylate.html","C19H17N5O2.2CH4O3S","Dimesylate","Futhan, FUT-175","C[S](O)(=O)=O.C[S](O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(N)=N",1.364,2,3,6]
["S1389","Omeprazole","a9","L2600-02","in 10mM DMSO","ATPase,Autophagy,Proton Pump","Transmembrane Transporters","Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.",345.42,"73590-58-6",{"v":69,"d":"69.00"},199.76,"<1","N/A","http://selleckchem.com/products/Omeprazole.html","C17H19N3O3S","free base","N/A","COC1=CC=C2[NH]C(=NC2=C1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.904,5,1,5]
["S1391","Oxcarbazepine","b9","L2600-02","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.",252.27,"28721-07-5",{"v":7,"d":"7.00"},27.75,"<1","N/A","http://selleckchem.com/products/Oxcarbazepine.html","C15H12N2O2","free base","GP47680","NC(=O)N1C2=C(CC(=O)C3=C1C=CC=C3)C=CC=C2",2.131,2,1,0]
["S1396","Resveratrol (SRT501)","c9","L2600-02","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1","N/A","http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1398","Stavudine (d4T)","d9","L2600-02","in 10mM DMSO","Reverse Transcriptase","Microbiology","Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.",224.21,"3056-17-5",{"v":45,"d":"45.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/Stavudine.html","C10H12N2O4","free base","BMY-27857, Sanilvudine, NSC 163661,d4T","CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O",-0.515,3,2,2]
["S1403","Tigecycline (GAR-936)","e9","L2600-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Bacterial","Microbiology","Tigecycline (Tygacil, GAR-936, WAY-GAR-936, TBG-MINO) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline induces autophagy by downregulating the PI3K-AKT-mTOR pathway.",585.65,"220620-09-7",{"v":100,"d":"100.00"},170.75,{"v":100,"d":"100.00"},170.75,"http://selleckchem.com/products/Tigecycline.html","C29H39N5O8","free base","Tygacil, GAR-936, WAY-GAR-936, TBG-MINO","CN(C)C1C2CC3CC4=C(C(=C(NC(=O)CNC(C)(C)C)C=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",-0.381,4,6,7]
["S1422","Droxinostat","f9","L2600-02","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.",243.69,"99873-43-5",{"v":49,"d":"49.00"},201.08,"<1","N/A","http://selleckchem.com/products/Droxinostat.html","C11H14ClNO3","free base","NS 41080","CC1=CC(=CC=C1OCCCC(=O)NO)Cl",{"v":2.4,"d":"2.400"},2,1,5]
["S1425","Ranolazine 2HCl","g9","L2600-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine 2HCl (RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.",500.46,"95635-56-6",{"v":100,"d":"100.00"},199.82,{"v":100,"d":"100.00"},199.82,"http://selleckchem.com/products/Ranolazine-dihydrochloride.html","C24H33N3O4.2HCl","Dihydrochloride","RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride","Cl.Cl.COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",3.755,3,2,9]
["S1431","Sildenafil Citrate","h9","L2600-02","in 10mM DMSO","PDE","Metabolism","Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.",{"v":666.7,"d":"666.70"},"171599-83-0",{"v":20,"d":"20.00"},{"v":30,"d":"30.00"},"<1","N/A","http://selleckchem.com/products/Sildenafil-citrate.html","C22H30N6O4S.C6H8O7","Citrate","N/A","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.OC(=O)CC(O)(CC(O)=O)C(O)=O",-2.107,9,1,12]
["S1451","Aurora A Inhibitor I (TC-S 7010)","a10","L2600-02","in 10mM DMSO","Apoptosis related,Aurora Kinase","Cell Cycle","Aurora A Inhibitor I (TC-S 7010) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.",588.07,"1158838-45-9",{"v":118,"d":"118.00"},200.66,"<1","N/A","http://selleckchem.com/products/Aurora-A-Inhibitor-I.html","C31H31ClFN7O2","free base","N/A","CCN1CCN(CC1)C(=O)CC2=CC=C(NC3=NC(=C(F)C=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)C=C2",5.621,4,3,9]
["S1454","PHA-680632","b10","L2600-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","PHA-680632 is a potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.",501.62,"398493-79-3",{"v":100,"d":"100.00"},199.35,"<1","N/A","http://selleckchem.com/products/PHA-680632.html","C28H35N7O2","free base","N/A","CCC1=CC=CC(=C1NC(=O)N2CC3=C(C2)C(=N[NH]3)NC(=O)C4=CC=C(C=C4)N5CCN(C)CC5)CC",4.339,3,3,6]
["S1458","Neflamapimod (VX-745)","c10","L2600-02","in 10mM DMSO","p38 MAPK","MAPK","Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.",436.26,"209410-46-8",{"v":15,"d":"15.00"},34.38,"<1","N/A","http://selleckchem.com/products/VX-745.html","C19H9Cl2F2N3OS","free base","N/A","FC1=CC(=C(SC2=NN3C=NC(=O)C(=C3C=C2)C4=C(Cl)C=CC=C4Cl)C=C1)F",5.342,3,0,3]
["S1460","SP600125","d10","L2600-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,FLT3,JNK,Serine/threonin kinase,Trk receptor","MAPK","SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.",220.23,"129-56-6",{"v":44,"d":"44.00"},199.79,"<1","N/A","http://selleckchem.com/products/SP600125.html","C14H8N2O","free base","Nsc75890","O=C1C2=C(C=CC=C2)C3=N[NH]C4=CC=CC1=C34",2.994,2,1,0]
["S1462","AZD6482","e10","L2600-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.",408.45,"1173900-33-8",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://selleckchem.com/products/azd6482.html","C22H24N4O4","free base","KIN-193","CC(NC1=CC=CC=C1C(O)=O)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.003,4,1,5]
["S1475","Pimasertib (AS-703026)","f10","L2600-02","in 10mM DMSO","MEK","MAPK","Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.",{"v":431.2,"d":"431.20"},"1236699-92-5",{"v":86,"d":"86.00"},199.44,"<1","N/A","http://selleckchem.com/products/AS703026.html","C15H15FIN3O3","free base","MSC1936369B, SAR 245509","OCC(O)CNC(=O)C1=CC=NC=C1NC2=C(F)C=C(I)C=C2",1.171,2,4,6]
["S1484","MC1568","g10","L2600-02","in 10mM DMSO","HDAC","Cytoskeletal Signaling","MC1568 is a selective HDAC inhibitor for maize HD1-A with IC50 of 100 nM in a cell-free assay. It is 34-fold more selective for HD1-A than HD1-B.",314.31,"852475-26-4",{"v":13,"d":"13.00"},41.36,"<1","N/A","http://selleckchem.com/products/MC1568.html","C17H15FN2O3","free base","N/A","C[N]1C=C(/C=C/C(=O)C2=CC=CC(=C2)F)C=C1\\C=C\\C(=O)NO",2.981,2,1,5]
["S1489","PIK-93","h10","L2600-02","in 10mM DMSO","PI4K","PI3K/Akt/mTOR","PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.",389.88,"593960-11-3",{"v":78,"d":"78.00"},200.06,"<1","N/A","http://selleckchem.com/products/PIK-93.html","C14H16ClN3O4S2","free base","N/A","CC(=O)NC1=NC(=C(S1)C2=CC(=C(Cl)C=C2)[S](=O)(=O)NCCO)C",1.076,4,3,6]
["S1490","Ponatinib (AP24534)","a11","L2600-02","in 10mM DMSO","Autophagy,Bcr-Abl,FGFR,PDGFR,Src,VEGFR","Angiogenesis","Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.",532.56,"943319-70-8",{"v":30,"d":"30.00"},56.33,"<1","N/A","http://selleckchem.com/products/AP24534.html","C29H27F3N6O","free base","AP24534","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F",4.884,3,1,7]
["S1515","Pracinostat (SB939)","b11","L2600-02","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.",358.48,"929016-96-6",{"v":72,"d":"72.00"},200.85,"<1","N/A","http://selleckchem.com/products/SB939.html","C20H30N4O2","free base","N/A","CCCCC1=NC2=CC(=CC=C2[N]1CCN(CC)CC)\\C=C\\C(=O)NO",{"v":3.71,"d":"3.710"},2,1,10]
["S1523","Voxtalisib (XL765) Analogue","c11","L2600-02","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",599.66,"1349796-36-6",{"v":12,"d":"12.00"},20.01,"<1","N/A","http://selleckchem.com/products/XL765(SAR245409).html","C31H29N5O6S","free base","SAR245409","COC1=CC(=CC(=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=C(NC(=O)C5=CC=C(C)C(=C5)OC)C=C4)OC",5.631,8,3,10]
["S1526","Quizartinib (AC220)","d11","L2600-02","in 10mM DMSO","Apoptosis related,FLT3,Target Protein Ligand","Angiogenesis","Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.",560.67,"950769-58-1",{"v":33,"d":"33.00"},58.86,"<1","N/A","http://selleckchem.com/products/AC-220.html","C29H32N6O4S","free base","N/A","CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=C[N]4C(=N3)SC5=CC(=CC=C45)OCCN6CCOCC6",5.064,6,2,8]
["S1529","Hesperadin","e11","L2600-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.",516.65,"422513-13-1",{"v":103,"d":"103.00"},199.36,"<1","N/A","http://selleckchem.com/products/Hesperadin.html","C29H32N4O3S","free base","N/A","CC[S](=O)(=O)NC1=CC=C2NC(=O)C(=C(NC3=CC=C(CN4CCCCC4)C=C3)/C5=CC=CC=C5)/C2=C1",4.071,3,3,8]
["S1530","BIX 02188","f11","L2600-02","in 10mM DMSO","MEK","MAPK","BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.",412.48,"1094614-84-2",{"v":43,"d":"43.00"},104.25,"<1","N/A","http://selleckchem.com/products/BIX-02188.html","C25H24N4O2","free base","N/A","CNC(=O)C1=CC=C\\2C(=C1)NC(=O)C2=C(\\NC3=CC(=CC=C3)CN(C)C)C4=CC=CC=C4",3.102,2,3,6]
["S1531","BIX 02189","g11","L2600-02","in 10mM DMSO","ERK,MEK","MAPK","BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.",440.54,"1094614-85-3",{"v":60,"d":"60.00"},{"v":136.2,"d":"136.20"},"<1","N/A","http://selleckchem.com/products/BIX-02189.html","C27H28N4O2","free base","N/A","CN(C)CC1=CC=CC(=C1)N/C(C2=CC=CC=C2)=C/3C(=O)NC4=CC(=CC=C34)C(=O)N(C)C",3.308,2,2,6]
["S1537","Vadimezan (ASA404)","h11","L2600-02","in 10mM DMSO","Antiviral,IFN,STING,TNF-alpha,VDA","Angiogenesis","Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.",282.29,"117570-53-3",{"v":7,"d":"7.00"},{"v":24.8,"d":"24.80"},"<1","N/A","http://selleckchem.com/products/DMXAA(ASA404).html","C17H14O4","free base","NSC 640488, DMXAA","CC1=C(C)C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(O)=O",3.601,3,0,2]
["S1541","Selisistat (EX 527)","a2","L2600-03","in 10mM DMSO","Sirtuin","Epigenetics","Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.",248.71,"49843-98-3",{"v":49,"d":"49.00"},197.02,"<1","N/A","http://selleckchem.com/products/EX-527.html","C13H13ClN2O","free base","SEN0014196","NC(=O)C1CCCC2=C1[NH]C3=C2C=C(Cl)C=C3",3.149,1,2,1]
["S1555","AZD8055","b2","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.",465.54,"1009298-09-2",{"v":50,"d":"50.00"},{"v":107.4,"d":"107.40"},"<1","N/A","http://selleckchem.com/products/AZD8055.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=C(C=C2)C(=NC(=N3)N4CCOCC4C)N5CCOCC5C",3.274,6,1,5]
["S1556","PHT-427","c2","L2600-03","in 10mM DMSO","Akt,PDPK1","PI3K/Akt/mTOR","PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.",409.61,"1191951-57-1",{"v":82,"d":"82.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHT-427.html","C20H31N3O2S2","free base","CS-0223","CCCCCCCCCCCCC1=CC=C(C=C1)[S](=O)(=O)NC2=NN=CS2",6.296,4,1,14]
["S1558","AT7867","d2","L2600-03","in 10mM DMSO","Akt,S6 Kinase","PI3K/Akt/mTOR","AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.",337.85,"857531-00-1",{"v":68,"d":"68.00"},201.27,"<1","N/A","http://selleckchem.com/products/AT7867.html","C20H20ClN3","free base","N/A","ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=C[NH]N=C4",{"v":3.85,"d":"3.850"},1,2,3]
["S1565","Lumacaftor (VX-809)","e2","L2600-03","in 10mM DMSO","CFTR","Transmembrane Transporters","Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.",452.41,"936727-05-8",{"v":90,"d":"90.00"},198.93,"<1","N/A","http://selleckchem.com/products/VX-809.html","C24H18F2N2O5","free base","VRT 826809","CC1=C(N=C(NC(=O)C2(CC2)C3=CC4=C(OC(F)(F)O4)C=C3)C=C1)C5=CC=CC(=C5)C(O)=O",6.411,5,1,5]
["S1567","Pomalidomide (CC-4047)","f2","L2600-03","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.",273.24,"19171-19-8",{"v":54,"d":"54.00"},197.63,"<1","N/A","http://selleckchem.com/products/Pomalidomide(CC-4047).html","C13H11N3O4","free base","CC-4047","NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",{"v":-0.65,"d":"-0.650"},4,2,1]
["S1568","PD318088","g2","L2600-03","in 10mM DMSO","MEK","MAPK","PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.",561.09,"391210-00-7",{"v":112,"d":"112.00"},199.61,"<1","N/A","http://selleckchem.com/products/PD318088.html","C16H13BrF3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C(=C1)Br)F",3.327,2,4,7]
["S1569","Tazarotene","h2","L2600-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.",351.46,"118292-40-3",{"v":10,"d":"10.00"},28.45,"<1","N/A","http://selleckchem.com/products/Tazarotene(Avage).html","C21H21NO2S","free base","AGN190168","CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(SCCC3(C)C)C=C2",4.951,3,0,5]
["S1573","Fasudil (HA-1077) HCl","a3","L2600-03","in 10mM DMSO","Autophagy,Calcium Channel,MLCK,PKA,PKC,PKG,Rho,ROCK","Cell Cycle","Fasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.",327.83,"105628-07-7",{"v":5,"d":"5.00"},15.25,{"v":65,"d":"65.00"},198.27,"http://selleckchem.com/products/Fasudil-HCl(HA-1077).html","C14H17N3O2S.HCl","Hydrochloride","AT-877,HA-1077 HCl","Cl.O=[S](=O)(N1CCCNCC1)C2=C3C=CN=CC3=CC=C2",{"v":0.57,"d":"0.570"},3,1,2]
["S1574","Doramapimod (BIRB 796)","b3","L2600-03","in 10mM DMSO","JNK,p38 MAPK,Raf,Src","MAPK","Doramapimod (BIRB 796) is a  pan-p38 MAPK inhibitor with IC50 of  38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2.",527.66,"285983-48-4",{"v":100,"d":"100.00"},189.52,"<1","N/A","http://selleckchem.com/products/BIRB-796-(Doramapimod).html","C31H37N5O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5)C(C)(C)C",5.907,4,2,8]
["S1576","Sulfasalazine (NSC 667219)","c3","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1","N/A","http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1582","H 89 2HCl","d3","L2600-03","in 10mM DMSO","Autophagy,PKA,PKG,S6 Kinase","PI3K/Akt/mTOR","H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM in a cell-free assay, 10-fold selective for PKA than PKG,500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. H 89 2HCl induces autophagy.",519.28,"130964-39-5",{"v":104,"d":"104.00"},200.28,{"v":6,"d":"6.00"},11.55,"http://selleckchem.com/products/H-89-dihydrochloride.html","C20H20BrN3O2S.2HCl","Dihydrochloride","N/A","Cl.Cl.BrC1=CC=C(/C=C/CNCCN[S](=O)(=O)C2=CC=CC3=C2C=CN=C3)C=C1",3.665,3,2,8]
["S1590","TWS119","e3","L2600-03","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.",318.33,"601514-19-6",{"v":64,"d":"64.00"},201.05,"<1","N/A","http://selleckchem.com/products/TWS119.html","C18H14N4O2","free base","N/A","NC1=CC(=CC=C1)C2=CC3=C([NH]2)N=CN=C3OC4=CC=CC(=C4)O",3.464,3,3,3]
["S1601","Reserpine","f3","L2600-03","in 10mM DMSO","VMAT","Transmembrane Transporters","Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).",608.68,"50-55-5",{"v":13,"d":"13.00"},21.36,"<1","N/A","http://selleckchem.com/products/Reserpine.html","C33H40N2O9","free base","N/A","COC1C(CC2CN3CCC4=C([NH]C5=C4C=CC(=C5)OC)C3CC2C1C(=O)OC)OC(=O)C6=CC(=C(OC)C(=C6)OC)OC",4.242,9,1,10]
["S1606","Clotrimazole","g3","L2600-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Fungal","Microbiology","Clotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.",344.84,"23593-75-1",{"v":11,"d":"11.00"},{"v":31.9,"d":"31.90"},"<1","N/A","http://selleckchem.com/products/Clotrimazole(Canesten).html","C22H17ClN2","free base","BAY b 5097, FB 5097","ClC1=C(C=CC=C1)C([N]2C=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.222,1,0,4]
["S1626","Naproxen Sodium","h3","L2600-03","in 10mM DMSO","COX","Neuronal Signaling","Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.",252.24,"26159-34-2",{"v":3,"d":"3.00"},11.89,{"v":50,"d":"50.00"},198.22,"http://selleckchem.com/products/Naproxen-Sodium(Aleve).html","C14H13NaO3","Sodium Salt","RS-3650","[Na+].COC1=CC=C2C=C(C=CC2=C1)C(C)C([O-])=O",1.375,1,0,3]
["S1627","Nitazoxanide (NSC 697855)","a4","L2600-03","in 10mM DMSO","Autophagy,Influenza Virus,mTOR,Serotonin Transporter","Microbiology","Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.",307.28,"55981-09-4",{"v":62,"d":"62.00"},201.77,"<1","N/A","http://selleckchem.com/products/Nitazoxanide(Alinia).html","C12H9N3O5S","free base","NTZ, NSC 697855","CC(=O)OC1=C(C=CC=C1)C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.398,4,1,5]
["S1635","Erythromycin","b4","L2600-03","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture","Microbiology","Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).",733.93,"114-07-8",{"v":147,"d":"147.00"},200.29,{"v":3,"d":"3.00"},4.09,"http://selleckchem.com/products/Erythromycin(E-Mycin).html","C37H67NO13","Free Base","E-Mycin","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O",1.792,8,3,7]
["S1638","Ibuprofen (NSC 256857)","c4","L2600-03","in 10mM DMSO","COX","Neuronal Signaling","Ibuprofen (NSC 256857, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.",206.28,"15687-27-1",{"v":41,"d":"41.00"},198.76,"<1","N/A","http://selleckchem.com/products/Ibuprofen(Advil).html","C13H18O2","free base","Dolgesic,NSC 256857","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S1647","Adenosine","d4","L2600-03","in 10mM DMSO","Adenosine Receptor,Nucleoside Analog/Antimetabolite","GPCR & G Protein","Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.",267.24,"58-61-7",{"v":12,"d":"12.00"},{"v":44.9,"d":"44.90"},"<1","N/A","http://selleckchem.com/products/Adenosine(Adenocard).html","C10H13N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-1.881,4,4,2]
["S1653","Tretinoin (NSC 122758)","e4","L2600-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.",{"v":300.4,"d":"300.40"},"302-79-4",{"v":60,"d":"60.00"},199.73,"<1","N/A","http://selleckchem.com/products/Tretinoin(Aberela).html","C20H28O2","free base","Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1655","Ezetimibe (SCH-58235)","f4","L2600-03","in 10mM DMSO","LDL","Metabolism","Ezetimibe (SCH-58235) is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.",{"v":409.4,"d":"409.40"},"163222-33-1",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/Ezetimibe(Zetia).html","C24H21F2NO3","free base","SCH-58235","OC(CCC1C(N(C1=O)C2=CC=C(F)C=C2)C3=CC=C(O)C=C3)C4=CC=C(F)C=C4",4.633,1,2,6]
["S1662","Isradipine","g4","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Isradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.",371.39,"75695-93-1",{"v":74,"d":"74.00"},199.25,"<1","N/A","http://selleckchem.com/products/Isradipine(Dynacirc).html","C19H21N3O5","free base","PN 200-110","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC3=NON=C23)C(=O)OC(C)C)C",2.168,7,1,6]
["S1685","Sulfanilamide","h4","L2600-03","in 10mM DMSO","Bacterial","Microbiology","Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.",{"v":172.2,"d":"172.20"},"63-74-1",{"v":34,"d":"34.00"},197.44,"<1","N/A","http://selleckchem.com/products/Sulfanilamide.html","C6H8N2O2S","free base","N/A","NC1=CC=C(C=C1)[S](N)(=O)=O",-0.212,2,2,1]
["S1689","Meprednisone","a5","L2600-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.",372.46,"1247-42-3",{"v":75,"d":"75.00"},201.37,"<1","N/A","http://selleckchem.com/products/Betapar(Meprednisone).html","C22H28O5","free base","NSC 527579, SCH 4358","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC2(C)C1(O)C(=O)CO",1.536,3,1,2]
["S1693","Carbamazepine","b5","L2600-03","in 10mM DMSO","Autophagy,Sodium Channel","Transmembrane Transporters","Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.",236.27,"298-46-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/Carbamazepine(Carbatrol).html","C15H12N2O","free base","NSC 169864","NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",2.679,1,1,0]
["S1703","Divalproex Sodium","c5","L2600-03","in 10mM DMSO","HDAC","Epigenetics","Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.",310.41,"76584-70-8",{"v":62,"d":"62.00"},199.74,{"v":62,"d":"62.00"},199.74,"http://selleckchem.com/products/Divalproex-sodium.html","C8H16O2.C8H15O2.Na","Sodium Salt","N/A","[Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O",4.025,1,0,10]
["S1714","Gemcitabine (LY-188011)","d5","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.",{"v":263.2,"d":"263.20"},"95058-81-4",{"v":52,"d":"52.00"},197.57,{"v":52,"d":"52.00"},197.57,"http://selleckchem.com/products/Gemcitabine(Gemzar).html","C9H11F2N3O4","Free Base","LY-188011, NSC 613327","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.394,3,3,2]
["S1723","Indomethacin (NSC-77541)","e5","L2600-03","in 10mM DMSO","COX","Neuronal Signaling","Indomethacin (NSC-77541, Indometacin) is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.",357.79,"53-86-1",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/Indomethacin(Indocid).html","C19H16ClNO4","free base","Indometacin,NSC-77541","COC1=CC=C2[N](C(=C(CC(O)=O)C2=C1)C)C(=O)C3=CC=C(Cl)C=C3",4.235,3,0,4]
["S1733","Methylprednisolone (NSC-19987)","f5","L2600-03","in 10mM DMSO","ACE,Apoptosis related,Autophagy,Glucocorticoid Receptor,Immunology & Inflammation related,Interleukins","Endocrinology & Hormones","Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.",374.47,"83-43-2",{"v":75,"d":"75.00"},200.28,"<1","N/A","http://selleckchem.com/products/Methylprednisolone.html","C22H30O5","free base","NSC-19987,U 7532","CC1CC2C3CCC(O)(C(=O)CO)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",1.512,2,2,2]
["S1734","Meloxicam","g5","L2600-03","in 10mM DMSO","COX","Neuronal Signaling","Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.",{"v":351.4,"d":"351.40"},"71125-38-7",{"v":30,"d":"30.00"},85.37,"<1","N/A","http://selleckchem.com/products/Meloxicam(Mobic).html","C14H13N3O4S2","free base","N/A","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=C(C)S3",0.255,4,2,2]
["S1738","Telmisartan","h5","L2600-03","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.",514.62,"144701-48-4",{"v":13,"d":"13.00"},25.26,"<1","N/A","http://selleckchem.com/products/Telmisartan(Micardis).html","C33H30N4O2","free base","BIBR 277","CCCC1=NC2=C(C=C(C=C2C)C3=NC4=C(C=CC=C4)[N]3C)[N]1CC5=CC=C(C=C5)C6=CC=CC=C6C(O)=O",7.799,3,0,7]
["S1744","Nicotinic Acid","a6","L2600-03","in 10mM DMSO","Vitamin","Metabolism","Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family.",123.11,"59-67-6",{"v":25,"d":"25.00"},203.07,{"v":2,"d":"2.00"},16.25,"http://selleckchem.com/products/Niacin(Nicotinic-acid).html","C6H5NO2","free base","N/A","OC(=O)C1=CC=CN=C1",0.309,2,0,1]
["S1747","Nimodipine","b6","L2600-03","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.",418.44,"66085-59-4",{"v":84,"d":"84.00"},200.75,"<1","N/A","http://selleckchem.com/products/Nimodipine(Nimotop).html","C21H26N2O7","free base","BAY E 9736","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C",2.361,5,1,10]
["S1759","Pitavastatin (NK-104) calcium","c6","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1762","Pyrazinamide","d6","L2600-03","in 10mM DMSO","Bacterial","Microbiology","Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.",123.11,"98-96-4",{"v":25,"d":"25.00"},203.07,{"v":12,"d":"12.00"},97.47,"http://selleckchem.com/products/Pyrazinamide(Pyrazinoic-acid-amide).html","C5H5N3O","free base","Pyrazinoic Acid Amide","NC(=O)C1=NC=CN=C1",-1.041,3,1,1]
["S1770","Sulfadiazine","e6","L2600-03","in 10mM DMSO","Antibiotics","Microbiology","Sulfadiazine is a sulfonamide antibiotic.",250.28,"68-35-9",{"v":50,"d":"50.00"},199.78,"<1","N/A","http://selleckchem.com/products/Sulfadiazine.html","C10H10N4O2S","free base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CC=N2",0.313,4,2,3]
["S1774","Thioguanine (NSC 752)","f6","L2600-03","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1782","Azacitidine (5-Azacytidine)","g6","L2600-03","in 10mM DMSO","Autophagy,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.",{"v":244.2,"d":"244.20"},"320-67-2",{"v":48,"d":"48.00"},196.56,"<1","N/A","http://selleckchem.com/products/Azacitidine(Vidaza).html","C8H12N4O5","free base","5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine","NC1=NC(=O)N(C=N1)C2OC(CO)C(O)C2O",-2.505,4,4,2]
["S1786","Verteporfin (CL 318952)","h6","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,TEAD,VDA,YAP","Angiogenesis","Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.  It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.",718.79,"129497-78-5",{"v":100,"d":"100.00"},139.12,"<1","N/A","http://selleckchem.com/products/Verteporfin(Visudyne).html","C41H42N4O8","free base","CL 318952, Visudyne","COC(=O)CCC1=C(C)C2=CC3=NC(=CC4=C(C)C(=C([NH]4)C=C5N=C(C=C1[NH]2)C(=C5C)CCC(O)=O)C=C)C6=CC=C(C(C(=O)OC)C36C)C(=O)OC",7.789,9,2,12]
["S1792","Simvastatin (MK 733)","a7","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1794","Fenofibrate (NSC-281319)","b7","L2600-03","in 10mM DMSO","Autophagy,P450 (e.g. CYP17),PPAR","Metabolism","Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.",360.83,"49562-28-9",{"v":72,"d":"72.00"},199.54,"<1","N/A","http://selleckchem.com/products/Fenofibrate(Tricor).html","C20H21ClO4","free base","NSC-281319","CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2",5.111,4,0,7]
["S1802","AICAR (Acadesine)","c7","L2600-03","in 10mM DMSO","AMPK,Mitophagy","PI3K/Akt/mTOR","AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.",258.23,"2627-69-2",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Acadesine.html","C9H14N4O5","free base","NSC105823, AICA Riboside","NC(=O)C1=C(N)[N](C=N1)C2OC(CO)C(O)C2O",-2.913,3,5,3]
["S1805","Acetylcholine Chloride","d7","L2600-03","in 10mM DMSO","AChR","Neuronal Signaling","The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.",181.66,"60-31-1",{"v":36,"d":"36.00"},198.17,{"v":36,"d":"36.00"},198.17,"http://www.selleck.cn/products/Acetylcholine-chloride.html","C7H16NO2.Cl","Chloride","ACh chloride","[Cl-].CC(=O)OCC[N+](C)(C)C",-3.869,2,0,4]
["S1808","Nifedipine (BAY-a-1040)","e7","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.",346.33,"21829-25-4",{"v":69,"d":"69.00"},199.23,"<1","N/A","http://selleckchem.com/products/Nifedipine(Adalat).html","C17H18N2O6","free base","BAY-a-1040","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC)C",1.766,4,1,6]
["S1829","Pranlukast","f7","L2600-03","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.",{"v":481.5,"d":"481.50"},"103177-37-3",{"v":11,"d":"11.00"},22.85,"<1","N/A","http://selleckchem.com/products/pranlukast.html","C27H23N5O4","free base","ONO-1078,ono-rs-411","O=C(NC1=CC2=C(C=C1)C(=O)C=C(O2)C3=NN=N[NH]3)C4=CC=C(OCCCCC5=CC=CC=C5)C=C4",4.232,7,2,9]
["S1831","Carvedilol","g7","L2600-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.",406.47,"72956-09-3",{"v":81,"d":"81.00"},199.28,"<1","N/A","http://selleckchem.com/products/carvedilol.html","C24H26N2O4","free base","BM-14190, SKF 105517","COC1=CC=CC=C1OCCNCC(O)COC2=C3C(=CC=C2)[NH]C4=C3C=CC=C4",4.014,3,3,10]
["S1835","Azithromycin (CP-62993)","h7","L2600-03","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Autophagy,Bacterial,COVID-19","Autophagy","Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.",748.98,"83905-01-5",{"v":100,"d":"100.00"},133.51,"<1","N/A","http://selleckchem.com/products/azithromycin-zithromax.html","C38H72N2O12","Free Base","XZ-450,CP-62993","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",2.078,7,3,7]
["S1840","Lomustine","a8","L2600-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.",{"v":233.7,"d":"233.70"},"13010-47-4",{"v":46,"d":"46.00"},196.83,"<1","N/A","http://selleckchem.com/products/Lomustine(CeeNU).html","C9H16ClN3O2","free base","NSC79037, Gleostine, CeeNU, CCNU","ClCCN(N=O)C(=O)NC1CCCCC1",2.394,2,1,4]
["S1847","Clemastine (HS-592) fumarate","b8","L2600-03","in 10mM DMSO","Autophagy,Histamine Receptor,mTOR","Neuronal Signaling","Clemastine Fumarate (HS-592, Meclastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Clemastine stimulates autophagy via mTOR pathway.",459.96,"14976-57-9",{"v":35,"d":"35.00"},76.09,"<1","N/A","http://selleckchem.com/products/Clemastine-Fumarate.html","C21H26ClNO.C4H4O4","Fumarate","HS-592 fumarate, Meclastine fumarate","CN1CCCC1CCOC(C)(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.OC(=O)\\C=C\\C(O)=O",{"v":1.81,"d":"1.810"},3,0,8]
["S1848","Curcumin","c8","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S1885","Felodipine","d8","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Felodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.",384.25,"72509-76-3",{"v":77,"d":"77.00"},200.39,"<1","N/A","http://selleckchem.com/products/Felodipine(Plendil).html","C18H19Cl2NO4","free base","CGH-869","CCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",3.549,4,1,6]
["S1896","Hydroxyurea (NSC-32065)","e8","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,HIV","DNA Damage/DNA Repair","Hydroxyurea (NSC-32065, NCI-C04831, Hydroxycarbamide) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.",76.05,"127-07-1",{"v":15,"d":"15.00"},197.24,{"v":15,"d":"15.00"},197.24,"http://selleckchem.com/products/Hydroxyurea(Cytodrox).html","CH4N2O2","free base","NCI-C04831, Hydroxycarbamide,NSC-32065","NC(=O)NO",{"v":-1.03,"d":"-1.030"},1,2,0]
["S1905","Amlodipine","f8","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",408.88,"88150-42-9",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Amlodipine(Norvasc).html","C20H25ClN2O5","free base","UK-48340","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C",1.576,5,2,10]
["S1909","Fluvastatin (XU-62-320) Sodium","g8","L2600-03","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Fluvastatin Sodium (Vastin,XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.",433.45,"93957-55-2",{"v":87,"d":"87.00"},200.72,{"v":1,"d":"1.00"},2.31,"http://selleckchem.com/products/Fluvastatin-Sodium(Lescol).html","C24H25FNNaO4","Sodium","Vastin,XU-62-320","[Na+].CC(C)[N]1C2=C(C=CC=C2)C(=C1\\C=C\\C(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3",{"v":2.77,"d":"2.770"},0,2,8]
["S1914","Pregnenolone","h8","L2600-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.",316.48,"145-13-1",{"v":22,"d":"22.00"},69.51,"<1","N/A","http://selleckchem.com/products/pregnenolone.html","C21H32O2","free base","3β-Hydroxy-5-pregnen-20-one","CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C",3.624,1,1,1]
["S1915","Sulfamethoxazole","a9","L2600-03","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sulfamethoxazole(Ro 4-2130) is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.",253.28,"723-46-6",{"v":51,"d":"51.00"},201.36,"<1","N/A","http://selleckchem.com/products/Sulfamethoxazole.html","C10H11N3O3S","free base","Ro 4-2130","CC1=CC(=NO1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.709,4,2,3]
["S1916","Sulfisoxazole","b9","L2600-03","in 10mM DMSO","Bacterial","Microbiology","Sulfisoxazole (NU-445) is a sulfonamide antibacterial with an oxazole substituent.",{"v":267.3,"d":"267.30"},"127-69-5",{"v":53,"d":"53.00"},198.28,"<1","N/A","http://selleckchem.com/products/Sulfisoxazole.html","C11H13N3O3S","free base","NU-445","CC1=NOC(=C1C)N[S](=O)(=O)C2=CC=C(N)C=C2",0.918,4,2,3]
["S1937","Isoniazid","c9","L2600-03","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.",137.14,"54-85-3",{"v":27,"d":"27.00"},196.88,{"v":27,"d":"27.00"},196.88,"http://selleckchem.com/products/Isoniazid(Tubizid).html","C6H7N3O","free base","N/A","NNC(=O)C1=CC=NC=C1",-0.811,2,2,1]
["S1950","Metformin HCl","d9","L2600-03","in 10mM DMSO","Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK","Metabolism","Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",165.62,"1115-70-4",{"v":33,"d":"33.00"},199.25,{"v":33,"d":"33.00"},199.25,"http://selleckchem.com/products/Metformin-hydrochloride(Glucophage).html","C4H11N5.HCl","Hydrochloride","1,1-Dimethylbiguanide HCl","Cl.CN(C)C(=N)NC(N)=N",{"v":-0.36,"d":"-0.360"},0,2,3]
["S1957","Sulfamethizole","e9","L2600-03","in 10mM DMSO","Bacterial","Microbiology","Sulfamethizole is a sulfathiazole antibacterial agent.",270.33,"144-82-1",{"v":54,"d":"54.00"},199.76,"<1","N/A","http://selleckchem.com/products/Sulfamethizole(Proklar).html","C9H10N4O2S2","free base","N/A","CC1=NN=C(N[S](=O)(=O)C2=CC=C(N)C=C2)S1",0.305,4,2,3]
["S1972","Tamoxifen (ICI 46474) Citrate","f9","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Endocrinology & Hormones","Tamoxifen Citrate (Istubal,ICI 46474 Citrate) is a selective estrogen receptor modulator (SERM). Tamoxifen Citrate is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis and autophagy.",563.64,"54965-24-1",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://selleckchem.com/products/Tamoxifen-Citrate(Nolvadex).html","C26H29NO.C6H8O7","Citrate","Istubal,ICI 46474 Citrate","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1973","Cyclocytidine HCl","g9","L2600-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.",261.66,"10212-25-6",{"v":10,"d":"10.00"},38.22,{"v":44,"d":"44.00"},168.16,"http://selleckchem.com/products/cyclocytidine-hcl.html","C9H12ClN3O4","Hydrochloride","NSC 145668 HCl","Cl.OCC1OC2C(OC3=NC(=N)C=CN23)C1O",-1.395,3,2,1]
["S1979","Amiodarone (NSC 85442) HCl","h9","L2600-03","in 10mM DMSO","Autophagy,Potassium Channel","Transmembrane Transporters","Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.",681.77,"19774-82-4",{"v":23,"d":"23.00"},33.74,"<1","N/A","http://selleckchem.com/products/amiodarone-hcl.html","C25H29I2NO3.HCl","Hydrochloride","Amiodar,Amiodarone hydrochloride,Nexterone","Cl.CCCCC1=C(C(=O)C2=CC(=C(OCCN(CC)CC)C(=C2)I)I)C3=C(O1)C=CC=C3",{"v":7.62,"d":"7.620"},3,0,11]
["S1990","Capsaicin(Vanilloid)","a10","L2600-03","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Capsaicin (Qutenza, Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.",305.41,"404-86-4",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://selleckchem.com/products/capsaicin.html","C18H27NO3","free base","Qutenza, Vanilloid","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C\\C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S1994","Lacidipine","b10","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.",455.54,"103890-78-4",{"v":91,"d":"91.00"},199.76,"<1","N/A","http://selleckchem.com/products/lacidipine-lacipil-motens.html","C26H33NO6","free base","GX-1048, GR-43659X, SN-305","CCOC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)\\C=C\\C(=O)OC(C)(C)C)C(=O)OCC)C",3.824,6,1,11]
["S2007","Sulindac","c10","L2600-03","in 10mM DMSO","COX","Neuronal Signaling","Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.",356.41,"38194-50-2",{"v":71,"d":"71.00"},199.21,"<1","N/A","http://selleckchem.com/products/Sulindac(Clinoril).html","C20H17FO3S","free base","MK-231","CC1=C(CC(O)=O)C2=C(C=CC(=C2)F)\\C1=C/C3=CC=C(C=C3)[S](C)=O",3.639,2,0,4]
["S2012","PCI-34051","d10","L2600-03","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.",296.32,"950762-95-5",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/pci-34051.html","C17H16N2O3","free base","N/A","COC1=CC=C(C[N]2C=CC3=C2C=C(C=C3)C(=O)NO)C=C1",2.911,2,1,4]
["S2018","ENMD-2076 L-(+)-Tartaric acid","e10","L2600-03","in 10mM DMSO","Aurora Kinase,FLT3,VEGFR","Angiogenesis","ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.",525.56,"1291074-87-7",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/enmd-2076-l-tartaric-acid.html","C25H31N7O6","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)\\C=C\\C4=CC=CC=C4.OC(C(O)C(O)=O)C(O)=O",-0.683,5,4,8]
["S2030","Flunarizine 2HCl","f10","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Flunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.",477.42,"30484-77-6",{"v":5,"d":"5.00"},10.47,"<1","N/A","http://selleckchem.com/products/flunarizine-dihydrochloride.html","C26H26F2N2.2HCl","2HCl","KW-3149, R14950","Cl.Cl.FC1=CC=C(C=C1)C(N2CCN(CC2)C\\C=C\\C3=CC=CC=C3)C4=CC=C(F)C=C4",6.699,0,0,6]
["S2043","Memantine HCl","g10","L2600-03","in 10mM DMSO","NMDAR","Neuronal Signaling","Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.",215.76,"41100-52-1",{"v":43,"d":"43.00"},{"v":199.3,"d":"199.30"},{"v":30,"d":"30.00"},139.04,"http://selleckchem.com/products/memantine-hydrochloride-namenda.html","C12H21N.HCl","Hydrochloride","N/A","Cl.CC12C[CH]3CC(C)([CH2]1)C[C](N)(C3)C2",2.289,0,1,0]
["S2055","Gimeracil","h10","L2600-03","in 10mM DMSO","Dehydrogenase","Metabolism","Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.",145.54,"103766-25-2",{"v":29,"d":"29.00"},199.26,"<1","N/A","http://selleckchem.com/products/gimeracil.html","C5H4ClNO2","free base","N/A","OC1=CC(=O)NC=C1Cl",-0.493,1,2,0]
["S2060","Bromhexine HCl","a11","L2600-03","in 10mM DMSO","Others","Others","Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.",412.59,"611-75-6",{"v":6,"d":"6.00"},14.54,"<1","N/A","http://selleckchem.com/products/bromhexine-hydrochloride.html","C14H20Br2N2.HCl","HCl","N/A","Cl.CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2",4.894,0,1,3]
["S2061","Lovastatin (MK-803)","b11","L2600-03","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Lovastatin (MK-803, Mevinolin,Mevacor) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.",404.54,"75330-75-5",{"v":8,"d":"8.00"},19.78,"<1","N/A","http://selleckchem.com/products/lovastatin-mevacor.html","C24H36O5","free base","Mevinolin,Mevacor","CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.218,4,1,7]
["S2077","Atorvastatin Calcium","c11","L2600-03","in 10mM DMSO","Apoptosis related,Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.",1155.34,"134523-03-8",{"v":100,"d":"100.00"},86.55,"<1","N/A","http://selleckchem.com/products/atorvastatin-calcium-lipitor.html","2(C33H34FN2O5).Ca","Calcium","N/A","[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8",8.163,2,6,24]
["S2080","Clevidipine Butyrate","d11","L2600-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Clevidipine Butyrate(Cleviprex) is a dihydropyridine calcium channel blocker,  uses as an agent for the reduction of blood pressure.",456.32,"167221-71-8",{"v":91,"d":"91.00"},199.42,"<1","N/A","http://selleckchem.com/products/cleviprex-clevidipine.html","C21H23Cl2NO6","free base","Cleviprex","CCCC(=O)OCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",4.145,6,1,10]
["S2090","Dexmedetomidine HCl","e11","L2600-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.",236.74,"145108-58-3",{"v":48,"d":"48.00"},202.75,"<1","N/A","http://selleckchem.com/products/dexmedetomidine-hcl-precedex.html","C13H16N2.HCl","HCl","(+)-Medetomidine Hydrochloride","Cl.CC(C1=CN=C[NH]1)C2=CC=CC(=C2C)C",3.378,1,1,2]
["S2098","Bexarotene (LGD1069)","f11","L2600-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.",{"v":348,"d":"348.00"},"153559-49-0",{"v":8,"d":"8.00"},22.99,"<1","N/A","http://selleckchem.com/products/bexarotene.html","C24H28O2","free base","Targretin","CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(O)=O)C(C)(C)CCC2(C)C",6.405,1,0,3]
["S2101","Gabexate Mesylate","g11","L2600-03","in 10mM DMSO","Serine Protease","Proteases","Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.",417.48,"56974-61-9",{"v":83,"d":"83.00"},198.81,{"v":12,"d":"12.00"},28.74,"http://selleckchem.com/products/gabexate-mesylate.html","C16H23N3O4.CH4O3S","Mesylate","FOY","CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1.C[S](O)(=O)=O",1.774,4,2,12]
["S2102","Rasagiline Mesylate","h11","L2600-03","in 10mM DMSO","MAO","Metabolism","Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.",267.34,"161735-79-1",{"v":53,"d":"53.00"},198.25,{"v":53,"d":"53.00"},198.25,"http://selleckchem.com/products/rasagiline-mesylate.html","C12H13N.CH4O3S","Mesylate","TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate","C[S](O)(=O)=O.C#CCNC1CCC2=CC=CC=C12",2.705,0,1,2]
["S2111","Lapatinib (GW-572016)","a2","L2600-04","in 10mM DMSO","Autophagy,EGFR,Ferroptosis,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.",581.06,"231277-92-2",{"v":100,"d":"100.00"},{"v":172.1,"d":"172.10"},"<1","N/A","http://selleckchem.com/products/lapatinib.html","C29H26ClFN4O4S","free base","GSK572016, GW2016","C[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(=C5)F)C(=C4)Cl)C3=C2",6.041,6,2,11]
["S2113","Cisatracurium Besylate","b2","L2600-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Cisatracurium Besylate(51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.",1243.48,"96946-42-8",{"v":249,"d":"249.00"},200.24,{"v":47,"d":"47.00"},{"v":37.8,"d":"37.80"},"http://selleckchem.com/products/cisatracurium-besylate-nimbex.html","C53H72N2O12.2C6H5O3S","Besylate","51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S2114","Dronedarone HCl","c2","L2600-04","in 10mM DMSO","Calcium Channel,Potassium Channel,Sodium Channel","Transmembrane Transporters","Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).",593.22,"141625-93-6",{"v":80,"d":"80.00"},134.86,"<1","N/A","http://selleckchem.com/products/dronedarone-hcl-multaq.html","C31H44N2O5S.HCl","HCl","SR33589","Cl.CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=CC=C(N[S](C)(=O)=O)C=C23",7.397,5,1,18]
["S2130","Atropine sulfate monohydrate","d2","L2600-04","in 10mM DMSO","AChR,ADC Cytotoxin","Neuronal Signaling","Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.",694.83,"5908-99-6",{"v":139,"d":"139.00"},200.05,{"v":139,"d":"139.00"},200.05,"http://selleckchem.com/products/Atropine-sulfate-monohydrate.html","2(C17H23NO3).H2O.H2SO4","Sulfate monohydrate","N/A","O.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.628,4,2,10]
["S2134","AZD8330","e2","L2600-04","in 10mM DMSO","MEK","MAPK","AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.",461.23,"869357-68-6",{"v":92,"d":"92.00"},199.47,"<1","N/A","http://selleckchem.com/products/AZD8330(ARRY-424704).html","C16H17FIN3O4","free base","ARRY704","CN1C(=O)C(=CC(=C1NC2=C(F)C=C(I)C=C2)C(=O)NOCCO)C",1.653,3,3,6]
["S2158","KW-2449","f2","L2600-04","in 10mM DMSO","Aurora Kinase,Bcr-Abl,FLT3","Angiogenesis","KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.",{"v":332.4,"d":"332.40"},"1000669-72-6",{"v":67,"d":"67.00"},201.56,"<1","N/A","http://selleckchem.com/products/KW-2449.html","C20H20N4O","free base","N/A","O=C(N1CCNCC1)C2=CC=C(C=C2)/C=C/C3=N[NH]C4=C3C=CC=C4",2.723,2,2,3]
["S2161","RAF265 (CHIR-265)","g2","L2600-04","in 10mM DMSO","Apoptosis related,Raf,VEGFR","MAPK","RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.",518.41,"927880-90-8",{"v":100,"d":"100.00"},{"v":192.9,"d":"192.90"},"<1","N/A","http://selleckchem.com/products/RAF265(CHIR-265).html","C24H16F6N6O","free base","N/A","C[N]1C(=NC2=C1C=CC(=C2)OC3=CC=NC(=C3)C4=NC=C([NH]4)C(F)(F)F)NC5=CC=C(C=C5)C(F)(F)F",6.469,4,2,7]
["S2163","PF-4708671","h2","L2600-04","in 10mM DMSO","Autophagy,S6 Kinase","PI3K/Akt/mTOR","PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.",390.41,"1255517-76-0",{"v":30,"d":"30.00"},76.84,"<1","N/A","http://selleckchem.com/products/pf-4708671.html","C19H21F3N6","free base","N/A","CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C([NH]3)C=CC(=C4)C(F)(F)F",3.886,3,1,5]
["S2170","Givinostat (ITF2357)","a3","L2600-04","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.",475.97,"732302-99-7",{"v":95,"d":"95.00"},199.59,"<1","N/A","http://selleckchem.com/products/ITF2357(Givinostat).html","C24H27N3O4.HCl.H2O","Chloride","N/A","O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC3=CC=C(C=C3)C(=O)NO)C=C2",4.046,3,2,9]
["S2179","Gandotinib (LY2784544)","b3","L2600-04","in 10mM DMSO","JAK","JAK/STAT","Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.",469.94,"1229236-86-5",{"v":94,"d":"94.00"},200.03,"<1","N/A","http://selleckchem.com/products/LY2784544.html","C23H25ClFN7O","free base","N/A","CC1=N[NH]C(=C1)NC2=N[N]3C(=C(C)N=C3C(=C2)CN4CCOCC4)CC5=CC=C(Cl)C=C5F",3.938,4,2,6]
["S2180","Ixazomib (MLN2238)","c3","L2600-04","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.",361.03,"1072833-77-2",{"v":72,"d":"72.00"},199.43,"<1","N/A","http://selleckchem.com/products/MLN-2238.html","C14H19BCl2N2O4","Free Base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B(O)O",3.344,2,2,7]
["S2181","Ixazomib Citrate (MLN9708) Analogue","d3","L2600-04","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.",517.12,"1201902-80-8",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://selleckchem.com/products/MLN9708.html","C20H23BCl2N2O9","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)CC(CC(O)=O)(O2)C(O)=O",3.497,7,2,10]
["S2198","SGI-1776 free base","e3","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,FLT3,Haspin Kinase,Pim","JAK/STAT","SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.",405.42,"1025065-69-3",{"v":81,"d":"81.00"},199.79,"<1","N/A","http://selleckchem.com/products/SGI-1776.html","C20H22F3N5O","free base","N/A","CN1CCC(CC1)CNC2=N[N]3C(=NC=C3C4=CC=CC(=C4)OC(F)(F)F)C=C2",5.206,3,1,6]
["S2199","Aliskiren Hemifumarate","f3","L2600-04","in 10mM DMSO","RAAS","Endocrinology & Hormones","Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.",609.83,"173334-58-2",{"v":100,"d":"100.00"},163.98,{"v":100,"d":"100.00"},163.98,"http://selleckchem.com/products/Aliskiren-hemifumarate.html","C30H53N3O6.1/2C4H4O4","fumarate salt","CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.COCCCOC2=C(OC)C=CC(=C2)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.OC(=O)\\C=C\\C(O)=O",1.735,12,8,40]
["S2215","DAPT (GSI-IX)","g3","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,Beta Amyloid,Secretase","Proteases","DAPT (GSI-IX, LY-374973) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.",432.46,"208255-80-5",{"v":86,"d":"86.00"},198.86,"<1","N/A","http://selleckchem.com/products/DAPT-GSI-IX.html","C23H26F2N2O4","free base","LY-374973","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC(C(=O)OC(C)(C)C)C2=CC=CC=C2",3.385,4,2,9]
["S2217","Irinotecan (CPT-11) HCl Trihydrate","h3","L2600-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.",677.18,"136572-09-3",{"v":100,"d":"100.00"},147.67,{"v":1,"d":"1.00"},1.48,"http://selleckchem.com/products/Irinotecan-Hcl-Trihydrate-Campto.html","C33H38N4O6.HCl.3H2O","HCl & trihydrat","CPT-11 HCl Trihydrate","O.O.O.Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=CC=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C15)C(O)(CC)C(=O)OC4",3.446,6,0,5]
["S2218","Torkinib (PP242)","a4","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,mTOR","PI3K/Akt/mTOR","Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242) induces mitophagy and apoptosis.",308.34,"1092351-67-1",{"v":61,"d":"61.00"},197.83,"<1","N/A","http://selleckchem.com/products/PP242.html","C16H16N6O","free base","N/A","CC(C)[N]1N=C(C2=CC3=C([NH]2)C=CC(=C3)O)C4=C(N)N=CN=C14",2.908,3,3,2]
["S2219","Momelotinib (CYT387)","b4","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,JAK","JAK/STAT","Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.",414.46,"1056634-68-4",{"v":74,"d":"74.00"},178.55,"<1","N/A","http://selleckchem.com/products/Cyt387.html","C23H22N6O2","free base","LM-1149 , CYT11387","O=C(NCC#N)C1=CC=C(C=C1)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.857,4,2,6]
["S2220","SB590885","c4","L2600-04","in 10mM DMSO","Raf","MAPK","SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.",453.54,"405554-55-4",{"v":5,"d":"5.00"},11.02,"<1","N/A","http://selleckchem.com/products/SB590885.html","C27H27N5O2","free base","N/A","CN(C)CCOC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=C\\4C(=C3)CCC4=N\\O)C5=CC=NC=C5",4.503,4,1,7]
["S2225","TAME","d4","L2600-04","in 10mM DMSO","APC,E3 Ligase","Cell Cycle","Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.",342.41,"901-47-3",{"v":69,"d":"69.00"},201.51,{"v":69,"d":"69.00"},201.51,"http://selleckchem.com/products/TAME.html","C14H22N4O4S","free base","N/A","COC(=O)C(CCCNC(N)=N)N[S](=O)(=O)C1=CC=C(C)C=C1",0.749,4,3,10]
["S2226","Idelalisib","e4","L2600-04","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.",415.42,"870281-82-6",{"v":83,"d":"83.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/CAL-101.html","C22H18FN7O","free base","CAL-101, GS-1101","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=NC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)F",3.624,5,2,5]
["S2227","PIK-294","f4","L2600-04","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.",489.53,"900185-02-6",{"v":98,"d":"98.00"},200.19,"<1","N/A","http://selleckchem.com/products/PIK-294.html","C28H23N7O2","free base","N/A","CC1=C(C=CC=C1)N2C(=O)C3=C(C=CC=C3C)N=C2C[N]4N=C(C5=CC(=CC=C5)O)C6=C(N)N=CN=C46",4.867,5,2,4]
["S2238","Palomid 529 (P529)","g4","L2600-04","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.",406.43,"914913-88-5",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/Palomid-529-P529.html","C24H22O6","free base","SG 00529","COC1=CC=C(COC2=C(OC)C=C3C(=C2)OC(=O)C4=C3C=CC(=C4)C(C)O)C=C1",4.257,5,1,6]
["S2243","Degrasyn (WP1130)","h4","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,DUB","Angiogenesis","Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.",384.27,"856243-80-6",{"v":77,"d":"77.00"},200.38,"<1","N/A","http://selleckchem.com/products/WP1130.html","C19H18BrN3O","free base","N/A","CCCC(NC(=O)/C(=C/C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",4.546,2,1,6]
["S2244","AR-42","a5","L2600-04","in 10mM DMSO","HDAC","Epigenetics","AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.",312.36,"935881-37-1",{"v":63,"d":"63.00"},201.69,"<1","N/A","http://selleckchem.com/products/AR-42-HDAC-42.html","C18H20N2O3","free base","HDAC-42","CC(C)C(C(=O)NC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",2.834,2,2,5]
["S2247","Buparlisib (BKM120)","b5","L2600-04","in 10mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.",410.39,"944396-07-0",{"v":82,"d":"82.00"},199.81,"<1","N/A","http://selleckchem.com/products/BKM-120.html","C18H21F3N6O2","free base","NVP-BKM120","NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F",2.342,5,1,4]
["S2248","Silmitasertib (CX-4945)","c5","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase","Metabolism","Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.",349.77,"1009820-21-6",{"v":16,"d":"16.00"},45.74,"<1","N/A","http://selleckchem.com/products/cx-4945-silmitasertib.html","C19H12ClN3O2","free base","N/A","OC(=O)C1=CC2=C(C=C1)C3=CN=CC=C3C(=N2)NC4=CC(=CC=C4)Cl",4.157,3,1,3]
["S2250","(-)-Epigallocatechin Gallate","d5","L2600-04","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2252","(+)-Usniacin","e5","L2600-04","in 10mM DMSO","Others","Others","(+)-Usniacin (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.",344.32,"7562-61-0",{"v":4,"d":"4.00"},11.62,"<1","N/A","http://selleckchem.com/products/Usniacin-D-Usnic-acid.html","C18H16O7","free base","D-Usnic Acid","CC(=O)C1=C(O)C(=C(O)C2=C1OC3=CC(=O)C(=C(O)C23C)C(C)=O)C",1.087,4,3,2]
["S2259","Aloe-emodin","f5","L2600-04","in 10mM DMSO","IFN","Immunology & Inflammation","Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.",270.24,"481-72-1",{"v":3,"d":"3.00"},{"v":11.1,"d":"11.10"},"<1","N/A","http://selleckchem.com/products/Aloe-emodin.html","C15H10O5","free base","NSC 38628, Rhabarberone","OCC1=CC2=C(C(=C1)O)C(=O)C3=C(C=CC=C3O)C2=O",1.719,2,3,1]
["S2261","Andrographolide","g5","L2600-04","in 10mM DMSO","NF-κB","NF-κB","Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.",350.45,"5508-58-7",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/Andrographolide.html","C20H30O5","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C\\3C(O)COC3=O)C(=C)CCC12",2.056,2,3,3]
["S2262","Apigenin (LY 080400)","h5","L2600-04","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Apigenin (NSC 83244, LY 080400) is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.",270.24,"520-36-5",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Apigenin.html","C15H10O5","free base","NSC 83244","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",{"v":2.41,"d":"2.410"},2,3,1]
["S2266","Asiatic Acid","a6","L2600-04","in 10mM DMSO","p38 MAPK","MAPK","Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.",{"v":488.7,"d":"488.70"},"464-92-6",{"v":97,"d":"97.00"},198.49,"<1","N/A","http://selleckchem.com/products/Asiatic-acid.html","C30H48O5","free base","Dammarolic acid, Asiantic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(O)=O",4.435,1,3,2]
["S2269","Baicalin (NSC-661431)","b6","L2600-04","in 10mM DMSO","GABA Receptor,PREP","Neuronal Signaling","Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.",446.36,"21967-41-9",{"v":89,"d":"89.00"},199.39,"<1","N/A","http://selleckchem.com/products/Baicalin.html","C21H18O11","free base","N/A","OC1C(O)C(OC(C1O)C(O)=O)OC2=C(O)C(=C3C(=O)C=C(OC3=C2)C4=CC=CC=C4)O",0.608,5,5,4]
["S2270","Bergenin","c6","L2600-04","in 10mM DMSO","Others","Others","Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.",328.27,"477-90-7",{"v":66,"d":"66.00"},201.05,"<1","N/A","http://selleckchem.com/products/Bergenin-(Cuscutin).html","C14H16O9","free base","Cuscutin","COC1=C(O)C2=C(C=C1O)C(=O)OC3C(O)C(O)C(CO)OC23",-0.849,4,5,2]
["S2271","Berberine chloride (NSC 646666)","d6","L2600-04","in 10mM DMSO","Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase","Microbiology","Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.",371.81,"633-65-8",{"v":40,"d":"40.00"},107.58,"<1","N/A","http://selleckchem.com/products/Berberine-Hydrochloride.html","C20H18NO4.Cl","chloride","Natural Yellow 18 chloride","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4",1.289,4,0,2]
["S2276","Bilobalide","e6","L2600-04","in 10mM DMSO","Others","Others","Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.",{"v":326.3,"d":"326.30"},"33570-04-6",{"v":65,"d":"65.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Bilobalide.html","C15H18O8","free base","N/A","CC(C)(C)C1(O)CC2OC(=O)CC23C(=O)OC4OC(=O)C(O)C134",-0.641,6,1,1]
["S2284","Colchicine (NSC 757)","f6","L2600-04","in 10mM DMSO","Microtubule Associated","Cell Cycle","Colchicine (NSC 757, Colchineos, Colchisol, Colcin) is a microtubule polymerization inhibitor with an IC50 of 3 nM.",399.44,"64-86-8",{"v":80,"d":"80.00"},200.28,{"v":80,"d":"80.00"},200.28,"http://selleckchem.com/products/colchicine.html","C22H25NO6","free base","Colchineos, Colchisol, Colcin,NSC 757","COC1=CC=C2C(=CC1=O)C(CCC3=C2C(=C(OC)C(=C3)OC)OC)NC(C)=O",2.044,6,1,5]
["S2285","Cryptotanshinone","g6","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,STAT","JAK/STAT","Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.",296.36,"35825-57-1",{"v":5,"d":"5.00"},16.87,"<1","N/A","http://selleckchem.com/products/Cryptotanshinone.html","C19H20O3","free base","Tanshinone C","CC1COC2=C1C(=O)C(=O)C3=C4CCCC(C)(C)C4=CC=C23",3.761,3,0,0]
["S2290","Dihydroartemisinin (DHA)","h6","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,NF-κB","NF-κB","Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.",284.35,"71939-50-9",{"v":56,"d":"56.00"},196.94,"<1","N/A","http://selleckchem.com/products/Dihydroartemisinin(DHA).html","C15H24O5","free base","Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol","CC1CCC2C(C)C(O)OC3OC4(C)CCC1C23OO4",1.621,4,0,0]
["S2295","Emodin","a7","L2600-04","in 10mM DMSO","Dehydrogenase","Metabolism","Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).",270.24,"518-82-1",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Emodin.html","C15H10O5","free base","N/A","CC1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(O)C=C3O)C2=O",2.568,2,3,0]
["S2301","Genistin (Genistoside)","b7","L2600-04","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Genistin (Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside) is an isoflavone found in a number of dietary plants like soy and kudzu. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of Estrogen Receptor α (ERα) signaling pathway.",432.37,"529-59-9",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Genistin(Genistoside).html","C21H20O10","free base","Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S2303","Gossypol Acetate","c7","L2600-04","in 10mM DMSO","Dehydrogenase","Metabolism","Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.",578.61,"12542-36-8",{"v":100,"d":"100.00"},172.83,"<1","N/A","https://www.selleckchem.com/products/gossypol-acetate.html","C32H34O10","Acetate","Gossypol Acetic acid, Pogosin, AT101","CC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(=C1O)O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C.CC(O)=O",6.388,3,6,5]
["S2308","Hesperetin","d7","L2600-04","in 10mM DMSO","Histamine Receptor,TGF-beta/Smad","TGF-beta/Smad","Hesperetin is a bioflavonoid and, to be more specific, a flavanone.",302.27,"520-33-2",{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/Hesperetin.html","C16H14O6","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.357,3,3,2]
["S2309","Hesperidin","e7","L2600-04","in 10mM DMSO","Others","Others","Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits.",610.56,"520-26-3",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/Hesperidin.html","C28H34O15","free base","Cirantin","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",-0.431,7,8,7]
["S2310","Honokiol (NSC 293100)","f7","L2600-04","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2312","Icariin","g7","L2600-04","in 10mM DMSO","PDE","Metabolism","Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.",676.66,"489-32-7",{"v":50,"d":"50.00"},73.89,"<1","N/A","http://selleckchem.com/products/Icariin.html","C33H40O15","free base","N/A","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O2)C(=C(OC5OC(CO)C(O)C(O)C5O)C=C4O)CC=C(C)C",0.983,7,8,9]
["S2313","Indole-3-carbinol","h7","L2600-04","in 10mM DMSO","NF-κB","NF-κB","Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.",147.18,"700-06-1",{"v":29,"d":"29.00"},197.04,{"v":7,"d":"7.00"},47.56,"http://selleckchem.com/products/Indole-3-carbinol.html","C9H9NO","free base","N/A","OCC1=C[NH]C2=C1C=CC=C2",1.518,0,2,1]
["S2314","Kaempferol (NSC 407289)","a8","L2600-04","in 10mM DMSO","Estrogen/progestogen Receptor,Fatty Acid Synthase","Endocrinology & Hormones","Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.",286.23,"520-18-3",{"v":57,"d":"57.00"},199.14,"<1","N/A","http://selleckchem.com/products/Kaempferol.html","C15H10O6","free base","Robigenin","OC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.872,2,4,1]
["S2321","Magnolol","b8","L2600-04","in 10mM DMSO","Fungal,NF-κB","NF-κB","Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.",266.33,"528-43-8",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Magnolol(2,2-Bichavicol).html","C18H18O2","free base","NSC 293099","OC1=C(C=C(CC=C)C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2323","Methyl-Hesperidin","c8","L2600-04","in 10mM DMSO","Akt,PKC","PI3K/Akt/mTOR","Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.",624.59,"11013-97-1",{"v":100,"d":"100.00"},155.62,{"v":100,"d":"100.00"},155.62,"http://selleckchem.com/products/Methyl-Hesperidin.html","C29H36O15","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(OC)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",{"v":-0.79,"d":"-0.790"},7,8,7]
["S2326","Myricetin","d8","L2600-04","in 10mM DMSO","MEK","MAPK","Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.",318.24,"529-44-2",{"v":63,"d":"63.00"},197.96,"<1","N/A","http://selleckchem.com/products/Myricetin(Cannabiscetin).html","C15H10O8","free base","Cannabiscetin","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O)O",1.388,2,6,1]
["S2333","Nobiletin (NSC 76751)","e8","L2600-04","in 10mM DMSO","MMP","Proteases","Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.",402.39,"478-01-3",{"v":81,"d":"81.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/Nobiletin(Hexamethoxyflavone).html","C21H22O8","free base","Hexamethoxyflavone","COC1=C(OC)C=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.038,8,0,7]
["S2334","Oleanolic Acid","f8","L2600-04","in 10mM DMSO","Antiviral","Microbiology","Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.",{"v":456.7,"d":"456.70"},"508-02-1",{"v":21,"d":"21.00"},45.98,"<1","N/A","http://selleckchem.com/products/Oleanolic-Acid(Caryophyllin).html","C30H48O3","free base","Caryophyllin","CC1(C)CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",6.282,1,1,1]
["S2341","(-)-Parthenolide","g8","L2600-04","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2347","Quercetin Dihydrate","h8","L2600-04","in 10mM DMSO","PI3K,Sirtuin","PI3K/Akt/mTOR","Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.",338.27,"6151-25-3",{"v":67,"d":"67.00"},198.07,"<1","N/A","http://selleckchem.com/products/Quercetin-dihydrate(Sophoretin).html","C15H10O7.2H2O","Dihydrate","Sophoretin","O.O.OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",1.216,2,5,1]
["S2348","Rotenone (Barbasco)","a9","L2600-04","in 10mM DMSO","Apoptosis related,Mitochondrial Metabolism,Mitophagy,NADPH-oxidase,ROS","Immunology & Inflammation","Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.",394.42,"83-79-4",{"v":78,"d":"78.00"},197.76,"N/A","N/A","http://selleckchem.com/products/rotenone-barbasco.html","C23H22O6","free base","Barbasco, Dactinol, Paraderil, Rotenon, Rotocide","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C(C=CC5=C4CC(O5)C(C)=C)C3=O",{"v":3.93,"d":"3.930"},6,0,3]
["S2350","Rutin","b9","L2600-04","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1","N/A","http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2357","Silibinin (NSC 651520)","c9","L2600-04","in 10mM DMSO","Others","Others","Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.",482.44,"22888-70-6",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silibinin(Silybin).html","C25H22O10","free base","Silybin, Silibinin A, Silymarin I, Flavobin","COC1=CC(=CC=C1O)C2OC3=CC(=CC=C3OC2CO)C4OC5=CC(=CC(=C5C(=O)C4O)O)O",2.592,5,5,4]
["S2366","Taxifolin (Dihydroquercetin)","d9","L2600-04","in 10mM DMSO","VEGFR","Angiogenesis","Taxifolin, type I inhibitor for VEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.",304.25,"480-18-2",{"v":60,"d":"60.00"},197.21,"<1","N/A","http://selleckchem.com/products/Taxifolin(Dihydroquercetin).html","C15H12O7","free base","N/A","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C=C3)O",1.479,2,5,1]
["S2370","Ursolic Acid","e9","L2600-04","in 10mM DMSO","Others","Others","Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.",{"v":456.7,"d":"456.70"},"77-52-1",{"v":91,"d":"91.00"},199.26,"<1","N/A","http://selleckchem.com/products/Ursolic-acid(Malol).html","C30H48O3","free base","NSC 167406, NSC-4060, Prunol, Urson, Malol","CC1CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",6.327,1,1,1]
["S2377","Biochanin A","f9","L2600-04","in 10mM DMSO","FAAH","Metabolism","Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.",284.26,"491-80-5",{"v":57,"d":"57.00"},200.52,"<1","N/A","http://selleckchem.com/products/Biochanin-A(4-Methylgenistein).html","C16H12O5","free base","4-Methylgenistein","COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O",2.366,3,2,2]
["S2391","Quercetin (NSC 9221)","g9","L2600-04","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src","Epigenetics","Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.",302.24,"117-39-5",{"v":61,"d":"61.00"},201.83,"<1","N/A","http://selleckchem.com/products/Quercetin(Sophoretin).html","C15H10O7","Free Base","Sophoretin, C.I. 75720","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S2396","Salidroside","h9","L2600-04","in 10mM DMSO","Mitophagy,mTOR,PREP","PI3K/Akt/mTOR","Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.",{"v":300.3,"d":"300.30"},"10338-51-9",{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Salidroside-Rhodioloside.html","C14H20O7","free base","Rhodioloside","OCC1OC(OCCC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.443,2,5,5]
["S2399","Dihydromyricetin","a10","L2600-04","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2400","Rheic Acid","b10","L2600-04","in 10mM DMSO","FTO,Immunology & Inflammation related","Immunology & Inflammation","Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.",284.22,"478-43-3",{"v":3,"d":"3.00"},10.56,"<1","N/A","http://www.selleck.cn/products/Rhein-Monorhein.html","C15H8O6","Free Base","Rhein, Monorhein, NSC 38629, Rheinic Acid","OC(=O)C1=CC(=C2C(=O)C3=C(C=CC=C3O)C(=O)C2=C1)O",1.954,3,2,1]
["S2401","Sodium Danshensu","c10","L2600-04","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.",220.15,"67920-52-9",{"v":7,"d":"7.00"},{"v":31.8,"d":"31.80"},{"v":2,"d":"2.00"},9.08,"http://selleckchem.com/products/Sodium-Danshensu.html","C9H9O5.Na","Sodium Salt","N/A","[Na+].OC(CC1=CC(=C(O)C=C1)O)C([O-])=O",-0.795,0,3,3]
["S2404","Isoliquiritigenin","d10","L2600-04","in 10mM DMSO","Aldose Reductase","Metabolism","Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.",256.25,"961-29-5",{"v":12,"d":"12.00"},46.83,"<1","N/A","http://selleckchem.com/products/Isoliquiritigenin.html","C15H12O4","free base","N/A","OC1=CC=C(C=C1)\\C=C\\C(=O)C2=C(O)C=C(O)C=C2",2.975,1,3,3]
["S2405","Sophocarpine","e10","L2600-04","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.",246.35,"6483-15-4",{"v":49,"d":"49.00"},{"v":198.9,"d":"198.90"},{"v":6,"d":"6.00"},24.36,"http://selleckchem.com/products/Sophocarpine.html","C15H22N2O","free base","N/A","O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.394,1,0,0]
["S2406","Chrysophanic Acid","f10","L2600-04","in 10mM DMSO","EGFR,mTOR","Protein Tyrosine Kinase","Chrysophanic Acid (Chrysophanol) a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.",254.24,"481-74-3",{"v":5,"d":"5.00"},19.67,"<1","N/A","http://selleckchem.com/products/Chrysophanic-acid-Chrysophanol.html","C15H10O4","free base","Chrysophanol","CC1=CC2=C(C(=C1)O)C(=O)C3=C(O)C=CC=C3C2=O",{"v":2.81,"d":"2.810"},2,2,0]
["S2412","Genipin","g10","L2600-04","in 10mM DMSO","Apoptosis related","Apoptosis","Genipin((+)-Genipin) is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.",226.23,"6902-77-8",{"v":45,"d":"45.00"},198.91,"<1","N/A","http://selleckchem.com/products/genipin.html","C11H14O5","free base","(+)-Genipin","COC(=O)C1=COC(O)C2C1CC=C2CO",-0.319,3,1,3]
["S2425","Apocynin (NSC 2146)","h10","L2600-04","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.",166.17,"498-02-2",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/apocynin-acetovanillone.html","C9H10O3","free base","Acetovanillone, NSC 209524","COC1=C(O)C=CC(=C1)C(C)=O",1.311,2,1,2]
["S2437","Rotundine","a11","L2600-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.",355.43,"483-14-7",{"v":8,"d":"8.00"},22.51,"<1","N/A","http://selleckchem.com/products/rotundine.html","C21H25NO4","free base","L-tetrahydropalmatine, L-THP","COC1=CC2=C(C=C1OC)C3CC4=CC=C(OC)C(=C4CN3CC2)OC",3.599,4,0,4]
["S2443","Tolbutamide (HLS 831)","b11","L2600-04","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.",270.35,"64-77-7",{"v":54,"d":"54.00"},199.74,"<1","N/A","http://selleckchem.com/products/tolbutamide.html","C12H18N2O3S","free base","HLS 831","CCCCNC(=O)N[S](=O)(=O)C1=CC=C(C)C=C1",2.336,3,2,5]
["S2446","Levosimendan","c11","L2600-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levosimendan(OR1259,OR1855,Simsndan) is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.",280.28,"141505-33-1",{"v":56,"d":"56.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/levosimendan.html","C14H12N6O","free base","OR1259,OR1855,Simsndan","CC1CC(=O)NN=C1C2=CC=C(NN=C(C#N)C#N)C=C2",1.486,3,2,3]
["S2448","Gambogic Acid","d11","L2600-04","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.",628.75,"2752-65-0",{"v":100,"d":"100.00"},159.05,"<1","N/A","http://selleckchem.com/products/gambogic-acid.html","C38H44O8","free base","Guttatic Acid, Guttic Acid, Beta-Guttiferrin","CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(=C2C=C1)O)C(=O)C4=CC5CC6C(C)(C)OC(C\\C=C(C)/C(O)=O)(C5=O)C46O3",6.957,6,1,8]
["S2449","Colforsin","e11","L2600-04","in 10mM DMSO","Autophagy,cAMP,FXR","GPCR & G Protein","Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.",{"v":410.5,"d":"410.50"},"66575-29-9",{"v":82,"d":"82.00"},199.76,"<1","N/A","http://selleckchem.com/products/forskolin.html","C22H34O7","free base","Forskolin, HL 362, Coleonol","CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C3(O)C(=O)CC(C)(OC13C)C=C",0.837,4,2,3]
["S2454","Bupivacaine HCl","f11","L2600-04","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.",324.89,"18010-40-7",{"v":65,"d":"65.00"},200.07,{"v":23,"d":"23.00"},70.79,"http://selleckchem.com/products/Bupivacaine-hydrochloride(Marcain).html","C18H28N2O.HCl","Hydrochloride","N/A","Cl.CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.692,1,1,5]
["S2456","Chlorpromazine HCl","g11","L2600-04","in 10mM DMSO","Dopamine Receptor,Potassium Channel","Neuronal Signaling","Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.",355.33,"69-09-0",{"v":71,"d":"71.00"},199.81,{"v":71,"d":"71.00"},199.81,"http://selleckchem.com/products/Chlorpromazine-hydrochloride(Sonazine).html","C17H19ClN2S.HCl","Hydrochloride","Sonazine","Cl.CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",5.121,0,0,4]
["S2458","Clonidine HCl","h11","L2600-04","in 10mM DMSO","Adrenergic Receptor,Autophagy","Neuronal Signaling","Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.",{"v":266.5,"d":"266.50"},"4205-91-8",{"v":53,"d":"53.00"},198.87,{"v":53,"d":"53.00"},198.87,"http://selleckchem.com/products/Clonidine-hydrochloride(Catapres).html","C9H9Cl2N3.HCl","Hydrochloride","Kapvay","Cl.ClC1=C(NC2=NCCN2)C(=CC=C1)Cl",2.736,1,2,2]
["S2475","Imatinib (STI571)","a2","L2600-05","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571,Gleevec, Glivec, CGP057148B) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.",{"v":493.6,"d":"493.60"},"152459-95-5",{"v":33,"d":"33.00"},66.86,"<1","N/A","http://selleckchem.com/products/Imatinib(STI571).html","C29H31N7O","free base","STI571,Gleevec, Glivec, CGP057148B","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",{"v":4.22,"d":"4.220"},4,2,7]
["S2480","Loperamide HCl","b2","L2600-05","in 10mM DMSO","Autophagy,Opioid Receptor","Neuronal Signaling","Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.",{"v":513.5,"d":"513.50"},"34552-83-5",{"v":22,"d":"22.00"},42.84,"<1","N/A","http://selleckchem.com/products/Loperamide-hydrochloride.html","C29H33ClN2O2.HCl","Hydrochloride","ADL 2-1294,R-18553 hydrochloride","Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.017,1,0,7]
["S2481","Manidipine","c2","L2600-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.",{"v":610.7,"d":"610.70"},"89226-50-6",{"v":122,"d":"122.00"},199.77,"<1","N/A","http://selleckchem.com/products/Manidipine(Manyper).html","C35H38N4O6","free base","CV-4093,(±)-Manidipine","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.058,4,1,12]
["S2482","Manidipine 2HCl","d2","L2600-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.",683.62,"89226-75-5",{"v":21,"d":"21.00"},30.72,"<1","N/A","http://selleckchem.com/products/Manidipine-dihydrochloride(CV-4093).html","C35H38N4O6.2HCl","Dihydrochloride","CV-4093","Cl.Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.822,4,1,12]
["S2491","Nitrendipine","e2","L2600-05","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.",360.37,"39562-70-4",{"v":72,"d":"72.00"},199.79,"<1","N/A","http://selleckchem.com/products/Nitrendipine.html","C18H20N2O6","free base","Bayotensin","CCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC)C",2.115,4,1,7]
["S2492","Novobiocin Sodium (NSC 2382)","f2","L2600-05","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.",634.61,"1476-53-5",{"v":100,"d":"100.00"},157.58,{"v":100,"d":"100.00"},157.58,"http://selleckchem.com/products/Novobiocin-sodium(Albamycin).html","C31H35N2O11.Na","Sodium Salt","Albamycin,Cathomycin,NSC 2382","[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=C(NC(=O)C4=CC=C([O-])C(=C4)CC=C(C)C)C(=O)OC3=C2C)O)OC1(C)C",2.747,8,4,9]
["S2493","Olanzapine","g2","L2600-05","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.",312.44,"132539-06-1",{"v":62,"d":"62.00"},198.44,"<1","N/A","http://selleckchem.com/products/Olanzapine(Zyprexa).html","C17H20N4S","free base","LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera","CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3",{"v":2.69,"d":"2.690"},1,1,1]
["S2505","Rosiglitazone (BRL-49653) maleate","h2","L2600-05","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",{"v":473.5,"d":"473.50"},"155141-29-0",{"v":94,"d":"94.00"},198.52,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-maleate.html","C18H19N3O3S.C4H4O4","Maleate","BRL-49653C","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=NC=CC=C3.OC(=O)\\C=C/C(O)=O",3.307,6,1,9]
["S2511","Sulfadoxine","a3","L2600-05","in 10mM DMSO","Anti-infection","Microbiology","Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.",310.33,"2447-57-6",{"v":62,"d":"62.00"},199.78,"<1","N/A","http://selleckchem.com/products/Sulfadoxine(Sulphadoxine).html","C12H14N4O4S","free base","Sulphadoxine","COC1=C(OC)C(=NC=N1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.837,6,2,5]
["S2517","Maprotiline HCl","b3","L2600-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.",313.86,"10347-81-6",{"v":63,"d":"63.00"},200.73,"<1","N/A","http://selleckchem.com/products/Maprotiline-hydrochloride.html","C20H23N.HCl","Hydrochloride","N/A","Cl.CNCCCC12CCC(C3=CC=CC=C13)C4=C2C=CC=C4",4.498,0,1,4]
["S2528","Ciclopirox","c3","L2600-05","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator.",207.27,"29342-05-0",{"v":42,"d":"42.00"},202.63,"<1","N/A","http://selleckchem.com/products/Ciclopirox-Penlac.html","C12H17NO2","Free Base","HOE 296b, Penlac","CC1=CC(=O)N(O)C(=C1)C2CCCCC2",2.489,1,0,1]
["S2553","5-Aminolevulinic acid HCl","d3","L2600-05","in 10mM DMSO","Others","Others","5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.",167.59,"5451-09-2",{"v":34,"d":"34.00"},202.88,{"v":34,"d":"34.00"},202.88,"http://selleckchem.com/products/5-Aminolevulinic-acid-hydrochloride.html","C5H9NO3.HCl","Hydrochloride","5-ALA hydrochloride","Cl.NCC(=O)CCC(O)=O",-3.318,2,1,4]
["S2554","Daphnetin","e3","L2600-05","in 10mM DMSO","EGFR,PKA,PKC","Angiogenesis","Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.",178.14,"486-35-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/Daphnetin.html","C9H6O4","free base","N/A","OC1=CC=C2C=CC(=O)OC2=C1O",1.415,2,2,0]
["S2555","Clarithromycin","f3","L2600-05","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.",747.95,"81103-11-9",{"v":25,"d":"25.00"},33.42,"<1","N/A","http://selleckchem.com/products/clarithromycin.html","C38H69NO13","free base","A-56268","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(CC(C)C(=O)C(C)C(O)C1(C)O)OC",{"v":2.2,"d":"2.200"},9,3,8]
["S2556","Rosiglitazone (BRL 49653)","g3","L2600-05","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",357.43,"122320-73-4",{"v":71,"d":"71.00"},198.64,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-Avandia.html","C18H19N3O3S","Free Base","BRL 49653","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",3.268,4,1,7]
["S2566","Isoprenaline (NCI-C55630) HCl","h3","L2600-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.",247.72,"51-30-9",{"v":50,"d":"50.00"},201.84,{"v":50,"d":"50.00"},201.84,"http://selleckchem.com/products/Isoprenaline-hydrochloride.html","C11H17NO3.HCl","Hydrochloride","NCI-c55630,Isoproterenol hydrochloride","Cl.CC(C)NCC(O)C1=CC=C(O)C(=C1)O",1.481,0,4,4]
["S2573","Tetracaine HCl","a4","L2600-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Tetracaine HCl (Amethocaine hydrochloride) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.",300.82,"136-47-0",{"v":60,"d":"60.00"},199.45,{"v":60,"d":"60.00"},199.45,"http://selleckchem.com/products/tetracaine-hydrochloride-pontocaine.html","C15H24N2O2.HCl","Hydrochloride","Amethocaine hydrochloride","Cl.CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C",3.343,2,1,9]
["S2593","Tolvaptan","b4","L2600-05","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Tolvaptan (OPC-41061) is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM, used to treat hyponatremia.",448.94,"150683-30-0",{"v":89,"d":"89.00"},198.24,"<1","N/A","http://selleckchem.com/products/tolvaptan-opc-41061.html","C26H25ClN2O3","free base","OPC-41061","CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(O)C4=C3C=CC(=C4)Cl)C",5.127,2,2,3]
["S2606","Mifepristone (RU486)","c4","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.",429.59,"84371-65-3",{"v":85,"d":"85.00"},197.86,"<1","N/A","http://selleckchem.com/products/Mifepristone(Mifeprex).html","C29H35NO2","free base","RU486, C-1073, RU 38486, RU-486, Mifegyne","CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)C5=CC=C(C=C5)N(C)C",5.655,1,0,3]
["S2615","Noradrenaline bitartrate monohydrate","d4","L2600-05","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.",337.28,"108341-18-0",{"v":64,"d":"64.00"},189.75,{"v":64,"d":"64.00"},189.75,"http://selleckchem.com/products/noradrenaline-bitartrate-monohydrate-levophed.html","C8H11NO3.C4H6O6.H2O","bitartrate monohydrate","Levophed","O.NCC(O)C1=CC(=C(O)C=C1)O.OC(C(O)C(O)=O)C(O)=O",-4.409,2,6,5]
["S2617","TAK-733","e4","L2600-05","in 10mM DMSO","MEK","MAPK","TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.",504.23,"1035555-63-5",{"v":101,"d":"101.00"},200.31,"<1","N/A","http://selleckchem.com/products/tak-733.html","C17H15F2IN4O4","free base","N/A","CN1C(=O)C(=C(NC2=CC=C(I)C=C2F)C3=C1N=CN(CC(O)CO)C3=O)F",0.383,3,3,5]
["S2619","MG132","f4","L2600-05","in 10mM DMSO","Proteasome","Proteases","MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor.  MG132 also inhibits calpain (IC50=1.2 μM).",475.62,"1211877-36-9",{"v":90,"d":"90.00"},189.23,"<1","N/A","http://selleckchem.com/products/MG132.html","C26H41N3O5","free base","(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al","CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",4.371,5,3,15]
["S2622","PP121","g4","L2600-05","in 10mM DMSO","Bcr-Abl,DNA-PK,mTOR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.",319.36,"1092788-83-4",{"v":64,"d":"64.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/PP121.html","C17H17N7","free base","N/A","NC1=NC=NC2=C1C(=N[N]2C3CCCC3)C4=CN=C5[NH]C=CC5=C4",2.583,4,2,2]
["S2624","OSI-027","h4","L2600-05","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1","N/A","http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2626","Rabusertib (LY2603618)","a5","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,Chk","Cell Cycle","Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.",{"v":436.3,"d":"436.30"},"911222-45-2",{"v":13,"d":"13.00"},{"v":29.8,"d":"29.80"},"<1","N/A","http://selleckchem.com/products/LY2603618-IC-83.html","C18H22BrN5O3","free base","IC-83","CC1=NC=C(NC(=O)NC2=C(OCC3CNCCO3)C=C(C)C(=C2)Br)N=C1",{"v":1.58,"d":"1.580"},5,3,5]
["S2627","Tubastatin A HCl","b5","L2600-05","in 10mM DMSO","HDAC","Epigenetics","Tubastatin A HCl (TSA) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).",371.86,"1310693-92-5",{"v":74,"d":"74.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/tubastatin-a-hcl.html","C20H21N3O2.HCl","Hydrochloride","TSA HCl","Cl.CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=C(C=C4)C(=O)NO",3.463,1,1,3]
["S2634","Rebastinib (DCC-2036)","c5","L2600-05","in 10mM DMSO","Bcr-Abl","Angiogenesis","Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.",553.59,"1020172-07-9",{"v":111,"d":"111.00"},200.51,"<1","N/A","http://selleckchem.com/products/dcc-2036.html","C30H28FN7O3","free base","N/A","CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(NC(=O)NC3=CC(=N[N]3C4=CC5=C(C=C4)N=CC=C5)C(C)(C)C)C=C2)F",{"v":5.14,"d":"5.140"},6,3,7]
["S2635","CCT128930","d5","L2600-05","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.",341.84,"885499-61-6",{"v":68,"d":"68.00"},198.92,"<1","N/A","http://selleckchem.com/products/cct128930.html","C18H20ClN5","free base","N/A","NC1(CCN(CC1)C2=C3C=C[NH]C3=NC=N2)CC4=CC=C(Cl)C=C4",2.813,2,2,3]
["S2639","SNX-2112 (PF-04928473)","e5","L2600-05","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.",464.48,"908112-43-6",{"v":93,"d":"93.00"},200.22,"<1","N/A","http://selleckchem.com/products/snx-2112.html","C23H27F3N4O3","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC(=C(C=C3)C(N)=O)NC4CCC(O)CC4",3.709,3,3,5]
["S2658","Omipalisib (GSK2126458)","f5","L2600-05","in 10mM DMSO","Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.",{"v":505.5,"d":"505.50"},"1086062-66-9",{"v":100,"d":"100.00"},197.82,"<1","N/A","http://selleckchem.com/products/gsk2126458.html","C25H17F2N5O3S","free base","GSK458","COC1=NC=C(C=C1N[S](=O)(=O)C2=CC=C(F)C=C2F)C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3",3.705,7,1,6]
["S2661","WYE-125132 (WYE-132)","g5","L2600-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.",{"v":519.6,"d":"519.60"},"1144068-46-1",{"v":104,"d":"104.00"},200.15,"<1","N/A","http://selleckchem.com/products/wye-125132.html","C27H33N7O4","free base","N/A","CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7",2.093,7,2,4]
["S2664","Clinofibrate","h5","L2600-05","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.",468.58,"30299-08-2",{"v":94,"d":"94.00"},200.61,"<1","N/A","http://selleckchem.com/products/clinofibrate.html","C28H36O6","free base","N/A","CCC(C)(OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(OC(C)(CC)C(O)=O)C=C3)C(O)=O",6.829,4,0,10]
["S2666","PF-3845","a6","L2600-05","in 10mM DMSO","FAAH","Metabolism","PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.",456.46,"1196109-52-0",{"v":91,"d":"91.00"},199.36,"<1","N/A","http://selleckchem.com/products/pf-3845.html","C24H23F3N4O2","free base","N/A","FC(F)(F)C1=CN=C(OC2=CC(=CC=C2)CC3CCN(CC3)C(=O)NC4=CN=CC=C4)C=C1",{"v":4.55,"d":"4.550"},4,1,6]
["S2671","AS-252424","b6","L2600-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AS-252424 is a novel, potent PI3Kγ inhibitor with IC50 of 30 nM in a cell-free assay with 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β.",305.28,"900515-16-4",{"v":61,"d":"61.00"},199.82,"<1","N/A","http://selleckchem.com/products/as-252424.html","C14H8FNO4S","free base","N/A","OC1=C(C=CC(=C1)F)C2=CC=C(O2)\\C=C3/SC(=O)NC3=O",{"v":3.11,"d":"3.110"},3,2,2]
["S2673","Trametinib (GSK1120212)","c6","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.",615.39,"871700-17-3",{"v":22,"d":"22.00"},35.75,"<1","N/A","http://selleckchem.com/products/gsk1120212-jtp-74057.html","C26H23FIN5O4","free base","JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(=CC=C5)NC(C)=O)C",3.176,4,2,5]
["S2679","Flavopiridol (L86-8275) HCl","d6","L2600-05","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.",{"v":438.3,"d":"438.30"},"131740-09-5",{"v":88,"d":"88.00"},200.78,"<1","N/A","http://selleckchem.com/products/flavopiridol-hydrochloride.html","C21H20ClNO5.HCl","Hydrochloride","NSC 649890, Alvocidib, HMR-1275, DSP-2033","Cl.CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,2]
["S2689","WAY-600","e6","L2600-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",494.59,"1062159-35-6",{"v":22,"d":"22.00"},44.48,"<1","N/A","http://selleckchem.com/products/way-600.html","C28H30N8O","free base","N/A","C1CN(CCO1)C2=NC(=NC3=C2C=N[N]3C4CCN(CC4)CC5=CC=CN=C5)C6=CC7=C([NH]C=C7)C=C6",2.946,5,1,5]
["S2692","TG101209","f6","L2600-05","in 10mM DMSO","c-RET,FLT3,JAK","JAK/STAT","TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.",509.67,"936091-14-4",{"v":102,"d":"102.00"},200.13,"<1","N/A","http://selleckchem.com/products/tg101209.html","C26H35N7O2S","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(C)C(=N3)NC4=CC(=CC=C4)[S](=O)(=O)NC(C)(C)C)C=C2",4.659,4,3,8]
["S2694","Turofexorate Isopropyl (XL335)","g6","L2600-05","in 10mM DMSO","FXR","Metabolism","Turofexorate Isopropyl (XL335, Fxr 450) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.",438.47,"629664-81-9",{"v":33,"d":"33.00"},75.26,"<1","N/A","http://selleckchem.com/products/way-362450.html","C25H24F2N2O3","free base","Fxr 450","CC(C)OC(=O)C1=CN(CC(C)(C)C2=C1[NH]C3=CC=CC=C23)C(=O)C4=CC=C(F)C(=C4)F",4.968,3,1,4]
["S2696","Apitolisib (GDC-0980)","h6","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.",{"v":498.6,"d":"498.60"},"1032754-93-0",{"v":20,"d":"20.00"},40.11,"<1","N/A","http://selleckchem.com/products/GDC-0980-RG7422.html","C23H30N8O3S","free base","RG7422, GNE 390","CC(O)C(=O)N1CCN(CC1)CC2=C(C)C3=NC(=NC(=C3S2)N4CCOCC4)C5=CN=C(N)N=C5",1.013,6,2,5]
["S2697","A-769662","a7","L2600-05","in 10mM DMSO","AMPK,Fatty Acid Synthase","PI3K/Akt/mTOR","A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.",360.39,"844499-71-4",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/a-769662.html","C20H12N2O3S","free base","N/A","OC1=CC=CC=C1C2=CC=C(C=C2)C3=CSC4=C3C(=C(C#N)C(=O)N4)O",3.135,1,3,2]
["S2699","CH5132799","b7","L2600-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CH5132799 (MEN1611, PA799) inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.",377.42,"1007207-67-1",{"v":12,"d":"12.00"},31.79,"<1","N/A","http://selleckchem.com/products/ch5132799.html","C15H19N7O3S","free base","MEN1611, PA799","C[S](=O)(=O)N1CCC2=C(N=C(N=C12)N3CCOCC3)C4=CN=C(N)N=C4",0.095,7,1,3]
["S2713","Geldanamycin (NSC 122750)","c7","L2600-05","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Antiviral,Autophagy,HSP (HSP90)","Cytoskeletal Signaling","Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.",560.64,"30562-34-6",{"v":36,"d":"36.00"},64.21,"<1","N/A","http://selleckchem.com/products/geldanamycin.html","C29H40N2O9","free base","NSC 122750","COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)\\C(=C\\C=C\\C(OC)C(OC(N)=O)\\C(=C\\C(C)C1O)C)C)C2=O",{"v":2.36,"d":"2.360"},8,3,5]
["S2718","TAK-901","d7","L2600-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.",504.64,"934541-31-8",{"v":101,"d":"101.00"},200.14,"<1","N/A","http://selleckchem.com/products/tak-901.html","C28H32N4O3S","free base","N/A","CC[S](=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C)C3=C2C4=C([NH]3)N=CC(=C4)C)C(=O)NC5CCN(C)CC5",4.056,4,2,5]
["S2719","AMG-900","e7","L2600-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.",503.58,"945595-80-2",{"v":100,"d":"100.00"},198.58,"<1","N/A","http://selleckchem.com/products/amg-900.html","C28H21N7OS","free base","N/A","CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=C(C=CC=N4)C5=NC(=NC=C5)N)C=C3)C6=C2C=CC=C6",6.487,6,2,6]
["S2720","ZM 336372","f7","L2600-05","in 10mM DMSO","Raf","MAPK","ZM 336372 (Zinc00581684) is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.",389.45,"208260-29-1",{"v":78,"d":"78.00"},200.28,"<1","N/A","http://selleckchem.com/products/zm-336372.html","C23H23N3O3","free base","Zinc00581684","CN(C)C1=CC=CC(=C1)C(=O)NC2=CC(=C(C)C=C2)NC(=O)C3=CC=C(O)C=C3",3.805,2,3,5]
["S2721","Nilvadipine","g7","L2600-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nilvadipine (ARC029, FR34235,FK235) is a potent calcium channel blocker with an IC50 of 0.03 nM.",385.37,"75530-68-6",{"v":77,"d":"77.00"},199.81,"<1","N/A","http://selleckchem.com/products/nilvadipine-arc029.html","C19H19N3O6","free base","ARC029, FR34235,FK235","COC(=O)C1=C(NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C)C#N",2.087,4,1,7]
["S2726","PH-797804","h7","L2600-05","in 10mM DMSO","p38 MAPK","MAPK","PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.",{"v":477.3,"d":"477.30"},"586379-66-0",{"v":96,"d":"96.00"},201.13,"<1","N/A","http://selleckchem.com/products/ph-797804.html","C22H19BrF2N2O3","free base","N/A","CNC(=O)C1=CC(=C(C)C=C1)N2C(=CC(=C(Br)C2=O)OCC3=CC=C(F)C=C3F)C",3.801,3,1,5]
["S2730","Crenolanib (CP-868596)","a8","L2600-05","in 10mM DMSO","FLT3,Mitophagy,PDGFR","Protein Tyrosine Kinase","Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.",443.54,"670220-88-9",{"v":88,"d":"88.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/crenolanib-cp-868596.html","C26H29N5O2","free base","ARO 002","CC1(COC1)COC2=CC3=C(C=C2)[N](C=N3)C4=NC5=C(C=CC=C5C=C4)N6CCC(N)CC6",3.192,4,1,5]
["S2736","Fedratinib (TG101348)","b8","L2600-05","in 10mM DMSO","Apoptosis related,c-RET,FLT3,JAK","JAK/STAT","Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.",524.68,"936091-26-8",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/Fedratinib-SAR302503-TG101348.html","C27H36N6O3S","free base","SAR302503","CC1=C(NC2=CC=CC(=C2)[S](=O)(=O)NC(C)(C)C)N=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=C1",5.123,5,3,11]
["S2738","PAC-1","c8","L2600-05","in 10mM DMSO","Caspase","Apoptosis","PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.",392.49,"315183-21-2",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/pac-1.html","C23H28N4O2","free base","N/A","OC1=C(CC=C)C=CC=C1/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3",3.331,2,2,8]
["S2740","GSK1070916","d8","L2600-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.",507.63,"942918-07-2",{"v":93,"d":"93.00"},{"v":183.2,"d":"183.20"},"<1","N/A","http://selleckchem.com/products/gsk1070916.html","C30H33N7O","free base","N/A","CC[N]1C=C(C2=C3C=C([NH]C3=NC=C2)C4=CC=CC(=C4)CN(C)C)C(=N1)C5=CC=C(NC(=O)N(C)C)C=C5",4.841,3,2,7]
["S2743","PF-04691502","e8","L2600-05","in 10mM DMSO","Akt,Apoptosis related,mTOR,PI3K","PI3K/Akt/mTOR","PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.",425.48,"1013101-36-4",{"v":14,"d":"14.00"},{"v":32.9,"d":"32.90"},"<1","N/A","http://selleckchem.com/products/pf-04691502.html","C22H27N5O4","free base","PF4691502","COC1=CC=C(C=N1)C2=CC3=C(C)N=C(N)N=C3N(C4CCC(CC4)OCCO)C2=O",1.616,6,2,6]
["S2746","AZ 628","f8","L2600-05","in 10mM DMSO","Apoptosis related,Raf","MAPK","AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.",451.52,"878739-06-1",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://selleckchem.com/products/az628.html","C27H25N5O2","free base","N/A","CN1C=NC2=C(C=C(NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)C=C2)C1=O",{"v":4.57,"d":"4.570"},3,2,5]
["S2749","BGT226 (NVP-BGT226) maleate","g8","L2600-05","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.",{"v":650.6,"d":"650.60"},"1245537-68-1",{"v":30,"d":"30.00"},46.11,"<1","N/A","http://selleckchem.com/products/nvp-bgt226.html","C28H25F3N6O2.C4H4O","maleate","N/A","COC1=NC=C(C=C1)C2=CC=C3N=CC4=C(N(C(=O)N4C)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F)C3=C2.OC(=O)\\C=C/C(O)=O",1.618,6,1,7]
["S2751","Milciclib (PHA-848125)","h8","L2600-05","in 10mM DMSO","Autophagy,CDK","Cell Cycle","Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.",460.57,"802539-81-7",{"v":92,"d":"92.00"},199.75,"<1","N/A","http://selleckchem.com/products/pha-848125.html","C25H32N8O","free base","N/A","CNC(=O)C1=N[N](C)C2=C1C(C)(C)CC3=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N=C23",3.825,4,2,4]
["S2759","Fimepinostat (CUDC-907)","a9","L2600-05","in 10mM DMSO","Apoptosis related,HDAC,PI3K","Cytoskeletal Signaling","CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1.",508.55,"1339928-25-4",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/pi3k-hdac-inhibitor-i.html","C23H24N8O4S","free base","N/A","COC1=CC=C(C=N1)C2=NC3=C(SC(=C3)CN(C)C4=NC=C(C=N4)C(=O)NO)C(=N2)N5CCOCC5",2.303,8,1,7]
["S2770","MK-5108 (VX-689)","b9","L2600-05","in 10mM DMSO","Aurora Kinase,Autophagy","Cell Cycle","MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.",461.94,"1010085-13-8",{"v":92,"d":"92.00"},199.16,"<1","N/A","http://selleckchem.com/products/mk-5108-vx-689.html","C22H21ClFN3O3S","free base","N/A","OC(=O)C1(CCC(CC1)OC2=C(F)C(=CC=C2)Cl)CC3=CC=CC(=N3)NC4=NC=CS4",5.574,4,1,7]
["S2775","Nocodazole (R17934)","c9","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,CRISPR/Cas9,Microtubule Associated","Cytoskeletal Signaling","Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.",301.32,"31430-18-9",{"v":7,"d":"7.00"},23.23,"<1","N/A","http://selleckchem.com/products/nocodazole.html","C14H11N3O3S","free base","Oncodazole, NSC238159","COC(=O)NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CS3",3.008,4,2,4]
["S2779","M344","d9","L2600-05","in 10mM DMSO","HDAC","Cytoskeletal Signaling","M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.",307.39,"251456-60-7",{"v":62,"d":"62.00"},{"v":201.7,"d":"201.70"},"<1","N/A","http://selleckchem.com/products/m344.html","C16H25N3O3","free base","N/A","CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO",2.004,2,2,9]
["S2781","RITA (NSC 652287)","e9","L2600-05","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2782","GW4064","f9","L2600-05","in 10mM DMSO","Autophagy,FXR","Metabolism","GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM. GW4064 stimulates autophagy in MCF-7 cells.",542.84,"278779-30-9",{"v":100,"d":"100.00"},184.22,"<1","N/A","http://selleckchem.com/products/gw-4064.html","C28H22Cl3NO4","free base","N/A","CC(C)C1=C(COC2=CC(=C(C=C2)/C=C/C3=CC=CC(=C3)C(O)=O)Cl)C(=NO1)C4=C(Cl)C=CC=C4Cl",8.682,4,0,8]
["S2783","Vistusertib (AZD2014)","g9","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.",462.54,"1009298-59-2",{"v":38,"d":"38.00"},82.16,"<1","N/A","http://selleckchem.com/products/azd2014.html","C25H30N6O3","free base","N/A","CNC(=O)C1=CC=CC(=C1)C2=CC=C3C(=N2)N=C(N=C3N4CCOCC4C)N5CCOCC5C",3.103,6,1,4]
["S2797","Lonafarnib (SCH66336)","h9","L2600-05","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2799","Daporinad","a10","L2600-05","in 10mM DMSO","Autophagy,NAMPT,Transferase","Metabolism","Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.",391.51,"658084-64-1",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://www.selleck.cn/products/apo866-fk866.html","C24H29N3O2","Free Base","FK866, APO866","O=C(NCCCCC1CCN(CC1)C(=O)C2=CC=CC=C2)/C=C/C3=CC=CN=C3",3.269,3,1,8]
["S2804","Sirtinol","b10","L2600-05","in 10mM DMSO","Sirtuin","Epigenetics","Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.",394.47,"410536-97-9",{"v":23,"d":"23.00"},58.31,"<1","N/A","http://selleckchem.com/products/sirtinol.html","C26H22N2O2","free base","N/A","CC(NC(=O)C1=CC=CC=C1N=CC2=C3C=CC=CC3=CC=C2O)C4=CC=CC=C4",5.262,2,2,5]
["S2807","Dabrafenib (GSK2118436)","c10","L2600-05","in 10mM DMSO","Raf","MAPK","Dabrafenib (GSK2118436, GSK2118436A) is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.",519.56,"1195765-45-7",{"v":30,"d":"30.00"},57.74,"<1","N/A","http://selleckchem.com/products/dabrafenib-gsk2118436.html","C23H20F3N5O2S2","free base","GSK2118436A","CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F",5.377,5,2,6]
["S2808","Ipatasertib (GDC-0068)","d10","L2600-05","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Ipatasertib (GDC-0068, RG7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.",{"v":458,"d":"458.00"},"1001264-89-6",{"v":92,"d":"92.00"},200.87,"<1","N/A","http://selleckchem.com/products/gdc-0068.html","C24H32ClN5O2","free base","RG7440","CC(C)NCC(C(=O)N1CCN(CC1)C2=C3C(C)CC(O)C3=NC=N2)C4=CC=C(Cl)C=C4",3.102,3,2,6]
["S2811","Sapanisertib (MLN0128)","e10","L2600-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.",309.33,"1224844-38-5",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://selleckchem.com/products/ink128.html","C15H15N7O","free base","INK 128,TAK-228","CC(C)[N]1N=C(C2=CC3=C(OC(=N3)N)C=C2)C4=C(N)N=CN=C14",1.886,5,2,2]
["S2812","(R)-(-)-Gossypol acetic acid","f10","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2","Apoptosis","(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.",578.61,"866541-93-7",{"v":116,"d":"116.00"},200.48,"<1","N/A","https://www.selleckchem.com/products/at101-acetic-acid.html","C30H30O8.C2H4O2","free base","AT-101 acetic acid, (-)-Gossypol acetic acid, (R)-Gossypol acetic acid","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(C)C=C4C(=C(O)C(=C(C=O)C4=C3O)O)C(C)C)O.CC(O)=O",6.388,3,6,5]
["S2814","Alpelisib (BYL719)","g10","L2600-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.",441.47,"1217486-61-7",{"v":88,"d":"88.00"},199.33,"<1","N/A","http://selleckchem.com/products/byl719.html","C19H22F3N5O2S","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CC(=NC=C3)C(C)(C)C(F)(F)F",2.826,4,2,5]
["S2817","Torin 2","h10","L2600-05","in 10mM DMSO","Apoptosis related,ATM/ATR,Autophagy,DNA-PK,mTOR","PI3K/Akt/mTOR","Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.",{"v":432.4,"d":"432.40"},"1223001-51-1",{"v":20,"d":"20.00"},46.25,"<1","N/A","http://selleckchem.com/products/torin-2.html","C24H15F3N4O","free base","N/A","NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(=O)C=C4)C5=CC=CC(=C5)C(F)(F)F)C3=C2",4.323,3,1,3]
["S2818","Tacedinaline (CI994)","a11","L2600-05","in 10mM DMSO","HDAC","Epigenetics","Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.",{"v":269.3,"d":"269.30"},"112522-64-2",{"v":54,"d":"54.00"},200.52,"<1","N/A","http://selleckchem.com/products/ci994-tacedinaline.html","C15H15N3O2","free base","PD-123654, GOE-5549, Acetyldinaline","CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N)C=CC=C2",0.988,2,3,3]
["S2843","BI-D1870","b11","L2600-05","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2853","Carfilzomib (PR-171)","c11","L2600-05","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,Proteasome","Proteases","Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.",719.91,"868540-17-4",{"v":50,"d":"50.00"},69.45,"<1","N/A","http://selleckchem.com/products/carfilzomib-pr-171.html","C40H57N5O7","free base","N/A","CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)C4(C)CO4",3.799,7,4,20]
["S2872","GW5074","d11","L2600-05","in 10mM DMSO","Apoptosis related,Raf","MAPK","GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted. GW5074 inhibits LK-induced apoptosis.",520.94,"220904-83-6",{"v":104,"d":"104.00"},199.64,"<1","N/A","http://selleckchem.com/products/gw5074.html","C15H8Br2INO2","free base","N/A","OC1=C(Br)C=C(C=C1Br)C=C2C(=O)NC3=CC=C(I)C=C23",4.564,1,2,1]
["S2882","IKK-16 (IKK Inhibitor VII)","e11","L2600-05","in 10mM DMSO","IκB/IKK,LRRK2","NF-κB","IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.",483.63,"873225-46-8",{"v":97,"d":"97.00"},200.57,"<1","N/A","http://selleckchem.com/products/ikk-16.html","C28H29N5OS","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC=C(NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5)C=C3",5.208,3,1,5]
["S2910","Tempol","f11","L2600-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.",172.24,"2226-96-2",{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},"http://selleckchem.com/products/tempol-4-hydroxy-tempo.html","C9H18NO2","free base","4-Hydroxy-TEMPO","CC1(C)CC(O)CC(C)(C)N1[O]",0.413,0,1,0]
["S2912","WZ811","g11","L2600-05","in 10mM DMSO","CXCR","GPCR & G Protein","WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.",290.36,"55778-02-4",{"v":30,"d":"30.00"},103.32,"<1","N/A","http://selleckchem.com/products/wz-811.html","C18H18N4","free base","N/A","C(NC1=NC=CC=C1)C2=CC=C(CNC3=NC=CC=C3)C=C2",3.391,2,2,6]
["S2913","BAY 11-7082","h11","L2600-05","in 10mM DMSO","Apoptosis related,DUB,IκB/IKK","NF-κB","BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.",207.25,"19542-67-7",{"v":41,"d":"41.00"},197.83,"<1","N/A","http://selleckchem.com/products/bay-11-7082-bay-11-7821.html","C10H9NO2S","free base","BAY 11-7821","CC1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",1.721,2,0,2]
["S2914","Dapivirine (TMC120)","a2","L2600-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.",{"v":329.4,"d":"329.40"},"244767-67-7",{"v":34,"d":"34.00"},103.22,"<1","N/A","http://selleckchem.com/products/dapivirine.html","C20H19N5","free base","N/A","CC1=CC(=C(NC2=CC=NC(=N2)NC3=CC=C(C=C3)C#N)C(=C1)C)C",5.549,2,2,4]
["S2919","IOX2","b2","L2600-06","in 10mM DMSO","HIF","Angiogenesis","IOX2 (JICL38) is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.",352.34,"931398-72-0",{"v":7,"d":"7.00"},19.87,"<1","N/A","http://selleckchem.com/products/iox2.html","C19H16N2O5","free base","JICL38","OC(=O)CNC(=O)C1=C(O)C2=C(C=CC=C2)N(CC3=CC=CC=C3)C1=O",1.153,3,2,5]
["S2923","Salubrinal","c2","L2600-06","in 10mM DMSO","eIF,PERK","Apoptosis","Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.",479.81,"405060-95-9",{"v":95,"d":"95.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/salubrinal.html","C21H17Cl3N4OS","free base","N/A","ClC(Cl)(Cl)C(NC(=O)\\C=C\\C1=CC=CC=C1)NC(=S)NC2=CC=CC3=C2N=CC=C3",{"v":5.82,"d":"5.820"},2,3,8]
["S2924","Laduviglusib (CHIR-99021) HCl","d2","L2600-06","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.",{"v":501.8,"d":"501.80"},"1797989-42-4",{"v":93,"d":"93.00"},185.33,"<1","N/A","http://selleckchem.com/products/chir-99021-ct99021-hcl.html","C22H18Cl2N8.HCl","Hydrochloride","CT99021 HCl","Cl.CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=NC=C(C=C3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.858,4,3,7]
["S2926","TDZD-8","e2","L2600-06","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.",222.26,"327036-89-5",{"v":44.5,"d":"44.50"},200.22,"<1","N/A","http://selleckchem.com/products/tdzd-8.html","C10H10N2O2S","free base","NP 01139","CN1SC(=O)N(CC2=CC=CC=C2)C1=O",2.145,2,0,2]
["S2927","Apoptosis Activator 2","f2","L2600-06","in 10mM DMSO","Caspase","Apoptosis","Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.",306.14,"79183-19-0",{"v":61,"d":"61.00"},199.26,"<1","N/A","http://selleckchem.com/products/apoptosis-activator-2.html","C15H9Cl2NO2","free base","N/A","ClC1=C(Cl)C=C(CN2C(=O)C(=O)C3=C2C=CC=C3)C=C1",3.788,2,0,2]
["S2928","TAK-715","g2","L2600-06","in 10mM DMSO","p38 MAPK","MAPK","TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.",399.51,"303162-79-0",{"v":80,"d":"80.00"},200.25,"<1","N/A","http://selleckchem.com/products/tak-715.html","C24H21N3OS","free base","N/A","CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C",5.629,3,1,5]
["S2929","Pifithrin-α (PFTα) HBr","h2","L2600-06","in 10mM DMSO","AhR,Autophagy,p53","Apoptosis","Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).",{"v":367.3,"d":"367.30"},"63208-82-2",{"v":67,"d":"67.00"},182.41,"<1","N/A","http://selleckchem.com/products/pifithrin-alpha.html","C16H18N2OS.HBr","HBr","Pifithrin-α hydrobromide","Br.CC1=CC=C(C=C1)C(=O)CN2C(=N)SC3=C2CCCC3",3.993,1,0,3]
["S2930","Pifithrin-μ","a3","L2600-06","in 10mM DMSO","Autophagy,HSP (HSP90),p53","Apoptosis","Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.",181.21,"64984-31-2",{"v":36,"d":"36.00"},198.66,"<1","N/A","http://selleckchem.com/products/pifithrin-u.html","C8H7NO2S","free base","NSC 303580, PFTμ, 2-Phenylethynesulfonamide","N[S](=O)(=O)C#CC1=CC=CC=C1",0.825,2,1,2]
["S3005","Paroxetine HCl","b3","L2600-06","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.",365.83,"78246-49-8",{"v":73,"d":"73.00"},199.55,{"v":1,"d":"1.00"},2.73,"http://selleckchem.com/products/paroxetine-hcl.html","C19H20FNO3.HCl","Hydrochloride","BRL-29060A, FG-7051","Cl.FC1=CC=C(C=C1)C2CCNCC2COC3=CC4=C(OCO4)C=C3",3.611,3,1,4]
["S3012","Pazopanib","c3","L2600-06","in 10mM DMSO","Autophagy,Cathepsin B,c-Kit,CSF-1R,Cysteine Protease,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.",437.52,"444731-52-6",{"v":87,"d":"87.00"},198.85,"<1","N/A","http://selleckchem.com/products/pazopanib.html","C21H23N7O2S","Free Base","GW786034","C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",3.741,5,2,5]
["S3017","Aspirin (NSC 27223)","d3","L2600-06","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3022","Cabazitaxel (XRP6258)","e3","L2600-06","in 10mM DMSO","Autophagy,Microtubule Associated","Cytoskeletal Signaling","Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.",835.93,"183133-96-2",{"v":100,"d":"100.00"},119.63,"<1","N/A","http://selleckchem.com/products/cabazitaxel-jevtana.html","C45H57NO14","free base","RPR-116258A, TXD 258, Taxoid XRP6258","COC1CC2OCC2(OC(C)=O)C3C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(OC)C(=O)C13C)C5(C)C)C",3.403,12,2,15]
["S3024","Lamotrigine","f3","L2600-06","in 10mM DMSO","5-HT Receptor,Sodium Channel","Transmembrane Transporters","Lamotrigine (BW-430C,LTG) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.",256.09,"84057-84-1",{"v":10,"d":"10.00"},39.05,"<1","N/A","http://selleckchem.com/products/lamotrigine.html","C9H7Cl2N5","free base","BW-430C,LTG","NC1=NC(=C(N=N1)C2=CC=CC(=C2Cl)Cl)N",2.426,3,2,1]
["S3025","PMSF","g3","L2600-06","in 10mM DMSO","Cysteine Protease,Serine Protease","Proteases","PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.",174.19,"329-98-6",{"v":35,"d":"35.00"},200.93,"<1","N/A","http://selleckchem.com/products/pmsf-phenylmethylsulfonyl-fluoride.html","C7H7FO2S","free base","Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride","F[S](=O)(=O)CC1=CC=CC=C1",1.459,2,0,2]
["S3026","Piceatannol","h3","L2600-06","in 10mM DMSO","Arginase,Syk","Angiogenesis","Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.",244.24,"10083-24-6",{"v":48,"d":"48.00"},196.53,"<1","N/A","http://selleckchem.com/products/piceatannol.html","C14H12O4","free base","N/A","OC1=CC(=CC(=C1)/C=C/C2=CC=C(O)C(=C2)O)O",2.848,0,4,2]
["S3030","Niclosamide (BAY2353)","a4","L2600-06","in 10mM DMSO","Autophagy,STAT","JAK/STAT","Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).",327.12,"50-65-7",{"v":8,"d":"8.00"},24.46,"<1","N/A","http://www.selleck.cn/products/niclosamide-niclocide.html","C13H8Cl2N2O4","Free Base","Niclocide, NSC 178296","OC1=CC=C(Cl)C=C1C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.595,1,2,3]
["S3031","Linagliptin (BI-1356)","b4","L2600-06","in 10mM DMSO","Autophagy,Ferroptosis","Proteases","Linagliptin (BI-1356,GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.",472.54,"668270-12-0",{"v":17,"d":"17.00"},35.98,"<1","N/A","http://selleckchem.com/products/linagliptin-bi-1356.html","C25H28N8O2","free base","GSK2118436","CC#CC[N]1C(=NC2=C1C(=O)N(CC3=NC4=CC=CC=C4C(=N3)C)C(=O)N2C)N5CCCC(N)C5",2.718,5,1,5]
["S3033","Vildagliptin (LAF-237)","c4","L2600-06","in 10mM DMSO","DPP","Proteases","Vildagliptin (LAF-237,NVP-LAF 237) inhibits DPP−4 with IC50 of 2.3 nM.",{"v":303.4,"d":"303.40"},"274901-16-5",{"v":60,"d":"60.00"},197.76,{"v":60,"d":"60.00"},197.76,"http://selleckchem.com/products/vildagliptin-laf-237.html","C17H25N3O2","free base","NVP-LAF 237","O[C]12CC3[CH2]C(C1)C[C](C3)(C2)NCC(=O)N4CCCC4C#N",0.179,1,1,3]
["S3035","Daunorubicin (RP 13057) HCl","d4","L2600-06","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,COVID-19,DNA/RNA Synthesis,Topoisomerase","DNA Damage/DNA Repair","Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.",563.98,"23541-50-6",{"v":100,"d":"100.00"},177.31,{"v":100,"d":"100.00"},177.31,"http://selleckchem.com/products/daunorubicin-hcl-daunomycin-hcl.html","C27H29NO10.HCl","Hydrochloride","Daunomycin HCl, Rubidomycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(C)=O)O)C(=O)C2=CC=C1",{"v":1.01,"d":"1.010"},6,4,4]
["S3036","Pravastatin sodium","e4","L2600-06","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.",446.51,"81131-70-6",{"v":89,"d":"89.00"},199.32,{"v":89,"d":"89.00"},199.32,"http://selleckchem.com/products/pravastatin-pravachol.html","C23H35O7.Na","sodium","CS-514 Sodium","[Na+].CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC([O-])=O)C12",0.682,2,3,11]
["S3052","Rupatadine Fumarate","f4","L2600-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively.",532.03,"182349-12-8",{"v":9,"d":"9.00"},16.92,"<1","N/A","http://selleckchem.com/products/rupatadine-fumarate.html","C26H26ClN3.C4H4O4","Fumarate","N/A","CC1=CN=CC(=C1)CN2CCC(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C35.OC(=O)\\C=C\\C(O)=O",2.672,4,0,4]
["S3053","Azelnidipine","g4","L2600-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.",582.65,"123524-52-7",{"v":117,"d":"117.00"},200.81,"<1","N/A","http://selleckchem.com/products/azelnidipine.html","C33H34N4O6","free base","UR-12592","CC(C)OC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC3CN(C3)C(C4=CC=CC=C4)C5=CC=CC=C5)N",4.941,4,2,11]
["S3116","Sulfathiazole","h4","L2600-06","in 10mM DMSO","Anti-infection","Microbiology","Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.",255.32,"72-14-0",{"v":51,"d":"51.00"},199.75,"<1","N/A","http://selleckchem.com/products/sulfathiazole.html","C9H9N3O2S2","free base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CS2",0.568,3,2,3]
["S3124","Dexamethasone Acetate","a5","L2600-06","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3132","Sulfamerazine","b5","L2600-06","in 10mM DMSO","Bacterial","Microbiology","Sulfamerazine (RP 2632,sulphamerazine) is a sulfonamide antibacterial.",{"v":264.3,"d":"264.30"},"127-79-7",{"v":53,"d":"53.00"},200.53,"<1","N/A","http://selleckchem.com/products/sulfamerazine.html","C11H12N4O2S","free base","RP 2632,sulphamerazine","CC1=NC(=NC=C1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.595,4,2,3]
["S3137","Sodium salicylate","c5","L2600-06","in 10mM DMSO","NF-κB","NF-κB","Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.",161.11,"54-21-7",{"v":32,"d":"32.00"},198.62,{"v":32,"d":"32.00"},198.62,"http://selleckchem.com/products/sodium-salicylate.html","C7H6O3.Na","sodium salt","2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt","[NaH].OC(=O)C1=CC=CC=C1O",1.217,1,1,1]
["S3201","Trifluoperazine 2HCl","d5","L2600-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).",480.42,"440-17-5",{"v":88,"d":"88.00"},183.17,{"v":96,"d":"96.00"},199.83,"http://selleckchem.com/products/trifluoperazine-dihydrochloride.html","C21H24F3N3S.2HCl","2HCl","SKF5019","Cl.Cl.CN1CCN(CCCN2C3=C(SC4=CC=C(C=C24)C(F)(F)F)C=CC=C3)CC1",5.739,0,0,5]
["S3212","Moclobemide (Ro 111163)","e5","L2600-06","in 10mM DMSO","MAO","Metabolism","Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.",268.74,"71320-77-9",{"v":53,"d":"53.00"},197.22,"<1","N/A","http://selleckchem.com/products/moclobemide.html","C13H17ClN2O2","free base","N/A","ClC1=CC=C(C=C1)C(=O)NCCN2CCOCC2",1.528,2,1,4]
["S3600","Schisandrin B (Sch B)","f5","L2600-06","in 10mM DMSO","ATM/ATR,P-gp","PI3K/Akt/mTOR","Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.",400.46,"61281-37-6",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://selleckchem.com/products/schisandrin-b.html","C23H28O6","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C4OCOC4=C3OC",5.067,6,0,4]
["S3603","Betulinic acid","g5","L2600-06","in 10mM DMSO","NF-κB,Topoisomerase","DNA Damage/DNA Repair","Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.",{"v":456.7,"d":"456.70"},"472-15-1",{"v":20,"d":"20.00"},43.79,"<1","N/A","http://selleckchem.com/products/betulinic-acid.html","C30H48O3","free base","ALS-357, Lupatic acid, Betulic acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C(O)=O",6.546,1,1,2]
["S3606","Fangchinoline","h5","L2600-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.",608.72,"33889-68-8",{"v":100,"d":"100.00"},164.28,"<1","N/A","http://selleckchem.com/products/r-s-fangchinoline.html","C37H40N2O6","free base","N/A","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C=C(OC6=C(O)C(=CC7=C6C(CC(=C2)C=C1)N(C)CC7)OC)C(=C5)OC)C=C3",6.992,5,1,3]
["S3609","Berbamine dihydrochloride","a6","L2600-06","in 10mM DMSO","Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",681.65,"6078-17-7",{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},"http://selleckchem.com/products/berbamine-dihydrochloride.html","C37H40N2O6.2HCl","dihydrochloride","BA, BBM","Cl.Cl.COC1=CC2=C3C=C1OC4=C(OC)C(=CC5=C4C(CC6=CC(=C(O)C=C6)OC7=CC=C(CC3N(C)CC2)C=C7)N(C)CC5)OC",7.756,5,1,3]
["S3610","Cordycepin","b6","L2600-06","in 10mM DMSO","MMP","Proteases","Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.",251.24,"73-03-0",{"v":50,"d":"50.00"},199.01,{"v":25,"d":"25.00"},99.51,"http://selleckchem.com/products/cordycepin.html","C10H13N5O3","free base","3'-Deoxyadenosine","NC1=NC=NC2=C1N=C[N]2C3OC(CO)CC3O",-1.308,4,3,2]
["S3611","(+)-Fangchinoline","c6","L2600-06","in 10mM DMSO","Others","Others","Fangchinoline ((+)-Limacine, Tetrandrine B, Hanfangichin B) is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity.",608.72,"436-77-1",{"v":40,"d":"40.00"},65.71,"<1","N/A","http://selleckchem.com/products/s-s-fangchinoline.html","C37H40N2O6","free base","(+)-Limacine, Tetrandrine B, Hanfangichin B","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C=C(OC6=C7C(CC(=C2)C=C1)N(C)CCC7=CC(=C6O)OC)C(=C5)OC)C=C3",6.992,5,1,3]
["S3652","3-Nitropropionic acid","d6","L2600-06","in 10mM DMSO","Dehydrogenase","Metabolism","3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.",119.08,"504-88-1",{"v":23,"d":"23.00"},193.15,{"v":23,"d":"23.00"},193.15,"http://selleckchem.com/products/3-nitropropionic-acid.html","C3H5NO4","free base","β-Nitropropionic Acid, 3-NP","OC(=O)CC[N+]([O-])=O",{"v":0.02,"d":"0.020"},1,0,3]
["S3653","Spermidine trihydrochloride","e6","L2600-06","in 10mM DMSO","Autophagy,NMDAR","Neuronal Signaling","Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).",254.63,"334-50-9",{"v":30,"d":"30.00"},117.82,{"v":50,"d":"50.00"},196.36,"http://selleckchem.com/products/spermidine-trihydrochloride.html","C7H19N3.3HCl","trihydrochloride","4-Azaoctamethylenediamine trihydrochloride","Cl.Cl.Cl.NCCCCNCCCN",-0.024,0,3,7]
["S3659","Fludrocortisone acetate","f6","L2600-06","in 10mM DMSO","Others","Others","Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.",422.49,"514-36-3",{"v":84,"d":"84.00"},198.82,"<1","N/A","http://selleckchem.com/products/fludrocortisone-acetate.html","C23H31FO6","free base","9α-fluorocortisol acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC12C",1.791,4,1,4]
["S3694","Glucosamine hydrochloride","g6","L2600-06","in 10mM DMSO","Others","Immunology & Inflammation","Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.",215.63,"66-84-2",{"v":4,"d":"4.00"},18.55,{"v":43,"d":"43.00"},199.42,"http://selleckchem.com/products/glucosamine-hydrochloride.html","C6H13NO5.HCl","hydrochloride","2-Amino-2-deoxy-glucose HCl, Chitosamine HCl","Cl.NC1C(O)OC(CO)C(O)C1O",-2.422,1,4,1]
["S3698","Nortriptyline hydrochloride","h6","L2600-06","in 10mM DMSO","Autophagy","Autophagy","Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.",299.84,"894-71-3",{"v":59,"d":"59.00"},196.77,{"v":59,"d":"59.00"},196.77,"http://selleckchem.com/products/nortriptyline-hydrochloride.html","C19H21N.HCl","hydrochloride","Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride","Cl.CNCCC=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.618,0,1,3]
["S3699","2,3-Butanedione-2-monoxime","a7","L2600-06","in 10mM DMSO","MLCK","Cytoskeletal Signaling","2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.",{"v":101.1,"d":"101.10"},"57-71-6",{"v":20,"d":"20.00"},197.82,{"v":20,"d":"20.00"},197.82,"http://selleckchem.com/products/2-3-butanedione-2-monoxime.html","C4H7NO2","free base","Diacetyl monoxime, Diacetylmonoxime","CC(=O)\\C(C)=N\\O",-0.161,2,0,1]
["S3746","Lumefantrine","b7","L2600-06","in 10mM DMSO","Anti-infection","Microbiology","Lumefantrine (benflumetol) is an antimalarial agent used to treat acute uncomplicated malaria.",528.94,"82186-77-4",{"v":13,"d":"13.00"},24.58,"<1","N/A","http://selleckchem.com/products/lumefantrine.html","C30H32Cl3NO","free base","benflumetol","CCCCN(CCCC)CC(O)C1=CC(=CC\\2=C1C3=C(C=C(Cl)C=C3)C2=C/C4=CC=C(Cl)C=C4)Cl",9.196,0,1,10]
["S3758","Sinomenine hydrochloride","c7","L2600-06","in 10mM DMSO","Autophagy,Immunology & Inflammation related","Immunology & Inflammation","Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.",365.85,"6080-33-7",{"v":73,"d":"73.00"},199.54,"N/A","N/A","http://selleckchem.com/products/sinomenine-hydrochloride.html","C19H23NO4.HCl","hydrochloride","Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride","Cl.COC1=C(O)C2=C(CC3C4C=C(OC)C(=O)CC24CCN3C)C=C1",2.056,3,1,2]
["S3792","Guggulsterone E&Z","d7","L2600-06","in 10mM DMSO","FXR","Metabolism","Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.",312.45,"95975-55-6",{"v":62,"d":"62.00"},198.43,"N/A","N/A","http://selleckchem.com/products/guggulsterone.html","C21H28O2","free base","N/A","CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",4.031,2,0,0]
["S3800","Lycorine hydrochloride","e7","L2600-06","in 10mM DMSO","ADC Cytotoxin,HCV Protease","Proteases","Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.",323.77,"2188-68-3",{"v":64,"d":"64.00"},197.67,"N/A","N/A","http://selleckchem.com/products/lycorine-hydrochloride.html","C16H17NO4.HCl","hydrochloride","Galanthidine hydrochloride, Amarylline hydrochloride, Narcissine hydrochloride, Licorine hydrochloride","Cl.OC1C=C2CCN3CC4=C(C=C5OCOC5=C4)C(C1O)C23",1.095,2,2,0]
["S3810","Scutellarin","f7","L2600-06","in 10mM DMSO","Akt,NF-κB,STAT","JAK/STAT","Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.",462.36,"27740-01-8",{"v":50,"d":"50.00"},108.14,"N/A","N/A","http://selleckchem.com/products/scutellarin.html","C21H18O12","free base","Breviscapine, Breviscapin, Scutellarein-7-glucuronide","OC1C(O)C(OC(C1O)C(O)=O)OC2=CC3=C(C(=O)C=C(O3)C4=CC=C(O)C=C4)C(=C2O)O",0.366,5,6,4]
["S3813","Bakuchiol","g7","L2600-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.",256.38,"10309-37-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/bakuchiol.html","C18H24O","free base","(S)-(+)-Bakuchiol","CC(C)=CCCC(C)(C=C)\\C=C\\C1=CC=C(O)C=C1",5.348,0,1,6]
["S3822","Schisandrin A","h7","L2600-06","in 10mM DMSO","AdipoR","Metabolism","Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.",416.51,"61281-38-7",{"v":83,"d":"83.00"},199.27,"N/A","N/A","http://selleckchem.com/products/schisandrin-a.html","C24H32O6","free base","Deoxyschizandrin, Wuweizisu A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C(OC)C(=C3OC)OC",5.266,6,0,6]
["S3823","Schizandrol A","a8","L2600-06","in 10mM DMSO","Others","Neuronal Signaling","Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.",432.51,"7432-28-2",{"v":86,"d":"86.00"},198.84,"N/A","N/A","http://selleckchem.com/products/schizandrol-a.html","C24H32O7","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)(O)C(C)C2)C=C(OC)C(=C3OC)OC",{"v":4.05,"d":"4.050"},6,0,6]
["S3824","Quercitrin","b8","L2600-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.",448.38,"522-12-3",{"v":89,"d":"89.00"},198.49,"N/A","N/A","http://selleckchem.com/products/quercitrin.html","C21H20O11","free base","3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine","CC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.589,4,7,3]
["S3829","Isoalantolactone","c8","L2600-06","in 10mM DMSO","Apoptosis related,Fungal","Apoptosis","Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia.  Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.",232.32,"470-17-7",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"N/A","N/A","http://selleckchem.com/products/isoalantolactone.html","C15H20O2","Sesquiterpene lactone","N/A","CC12CCCC(=C)C1CC3C(C2)OC(=O)C3=C",3.365,2,0,0]
["S3835","Loganin","d8","L2600-06","in 10mM DMSO","AChR,BACE,BChE","Neuronal Signaling","Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.",390.38,"18524-94-2",{"v":78,"d":"78.00"},199.81,"N/A","N/A","http://selleckchem.com/products/loganin.html","C17H26O10","free base","Loganoside","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)C(O)CC13",-1.895,5,5,5]
["S3839","1-Deoxynojirimycin","e8","L2600-06","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.",163.17,"19130-96-2",{"v":16,"d":"16.00"},98.06,"N/A","N/A","http://selleckchem.com/products/1-deoxynojirimycin.html","C6H13NO4","free base","duvoglustat, moranolin","OCC1NCC(O)C(O)C1O",{"v":-2.44,"d":"-2.440"},0,5,1]
["S3840","Baohuoside I","f8","L2600-06","in 10mM DMSO","ROS","Immunology & Inflammation","Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.",514.52,"113558-15-9",{"v":100,"d":"100.00"},194.36,"N/A","N/A","http://selleckchem.com/products/baohuoside-i.html","C27H30O10","Flavonoid glycoside","Icariside II","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O)C=C(O)C(=C4O2)CC=C(C)C",2.913,5,5,6]
["S3846","Eupatilin","g8","L2600-06","in 10mM DMSO","PPAR","Metabolism","Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.",344.32,"22368-21-4",{"v":68,"d":"68.00"},197.49,"N/A","N/A","http://selleckchem.com/products/eupatilin.html","C18H16O7","free base","NSC 122413","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)OC",2.603,5,2,4]
["S3868","Harmine","h8","L2600-06","in 10mM DMSO","MAO,PPAR","Metabolism","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",212.25,"442-51-3",{"v":42,"d":"42.00"},197.88,"N/A","N/A","http://selleckchem.com/products/harmine.html","C13H12N2O","free base","Telepathine","COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",2.438,2,1,1]
["S3869","Methyl protocatechuate","a9","L2600-06","in 10mM DMSO","Others","Others","Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.",168.15,"2150-43-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/methyl-protocatechuate.html","C8H8O4","free base","Methyl 3,4-dihydroxybenzoate; 3,4-Dihydroxybenzoic acid methyl ester; Protocatechuic Acid Methyl Ester","COC(=O)C1=CC(=C(O)C=C1)O",1.201,2,2,2]
["S3879","Kaempferide","b9","L2600-06","in 10mM DMSO","EGFR","Apoptosis","Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether), a natural compound derived from the roots of kaempferia galanga, has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.",300.26,"491-54-3",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://selleckchem.com/products/kaempferide.html","C16H12O6","free base","4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",2.098,3,3,2]
["S3889","Arteether","c9","L2600-06","in 10mM DMSO","Parasite","Microbiology","Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.",{"v":312.4,"d":"312.40"},"75887-54-6",{"v":62,"d":"62.00"},198.46,"N/A","N/A","http://selleckchem.com/products/arteether.html","C17H28O5","free base","N/A","CCOC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3",2.378,5,0,2]
["S3897","(-)-Arctigenin","d9","L2600-06","in 10mM DMSO","Influenza Virus","Microbiology","(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.",372.41,"7770-78-7",{"v":74,"d":"74.00"},198.71,"N/A","N/A","http://selleckchem.com/products/neg-rotation-arctigenin.html","C21H24O6","free base","N/A","COC1=C(O)C=CC(=C1)CC2C(COC2=O)CC3=CC=C(OC)C(=C3)OC",3.743,5,1,7]
["S3917","Tetrahydrocurcumin","e9","L2600-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties.  Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.",372.41,"36062-04-1",{"v":74,"d":"74.00"},{"v":198.7,"d":"198.70"},"<1","N/A","https://www.selleckchem.com/products/tetrahydrocurcumin.html","C21H24O6","free base","Tetrahydrodiferuloylmethane, Tetrahydro Curcumin","COC1=C(O)C=CC(=C1)CCC(=O)CC(=O)CCC2=CC=C(O)C(=C2)OC",-0.415,9,13,12]
["S3922","(-)-epigallocatechin","f9","L2600-06","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.",306.27,"970-74-1",{"v":61,"d":"61.00"},199.17,"N/A","N/A","http://selleckchem.com/products/neg-rotation-epigallocatechin.html","C15H14O7","free base","N/A","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S3924","Ginsenoside Rb1","g9","L2600-06","in 10mM DMSO","ATPase,IFN,IRAK,NF-κB,NOS,TLR,TNF-alpha","Transmembrane Transporters","Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.",1109.29,"41753-43-9",{"v":100,"d":"100.00"},90.15,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rb1.html","C54H92O23","free base","Gypenoside Ⅲ","CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-1.198,8,15,16]
["S3925","(-)-Epicatechin gallate","h9","L2600-06","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,"N/A","N/A","http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3934","Acetyl Resveratrol","a10","L2600-06","in 10mM DMSO","Others","Others","Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.",354.35,"42206-94-0",{"v":70,"d":"70.00"},197.54,"<1","N/A","https://www.selleckchem.com/products/acetyl-resveratrol.html","C20H18O6","free base","N/A","CC(=O)OC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC(C)=O)OC(C)=O",3.119,6,0,8]
["S3937","Pterostilbene","b10","L2600-06","in 10mM DMSO","Others","Others","Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.",{"v":256.3,"d":"256.30"},"537-42-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/pterostilbene.html","C16H16O3","free base","N/A","COC1=CC(=CC(=C1)\\C=C\\C2=CC=C(O)C=C2)OC",3.541,2,1,4]
["S3938","Bisdemethoxycurcumin (BDMC)","c10","L2600-06","in 10mM DMSO","Apoptosis related","Apoptosis","Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.",308.33,"33171-05-0",{"v":62,"d":"62.00"},201.08,"<1","N/A","http://selleckchem.com/products/bisdemethoxycurcumin.html","C19H16O4","free base","N/A","OC1=CC=C(C=C1)/C=C/C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",3.587,2,2,6]
["S3940","3'-Hydroxypterostilbene","d10","L2600-06","in 10mM DMSO","ERK,JNK,p38 MAPK,S6 Kinase","MAPK","3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.",{"v":272.3,"d":"272.30"},"475231-21-1",{"v":54,"d":"54.00"},198.31,"<1","N/A","http://selleckchem.com/products/3-hydroxypterostilbene.html","C16H16O4","free base","3'-HPT","COC1=CC(=CC(=C1)/C=C/C2=CC(=C(O)C=C2)O)OC",3.299,2,2,4]
["S3941","Pinocembrin","e10","L2600-06","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.",256.25,"480-39-7",{"v":51,"d":"51.00"},199.02,"<1","N/A","http://selleckchem.com/products/pinocembrin.html","C15H12O4","free base","Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone","OC1=CC2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O",2.615,2,2,1]
["S3944","Valproic acid (VPA)","f10","L2600-06","in 10mM DMSO","Autophagy,HDAC,Mitophagy,Notch,PGC-1α","Epigenetics","Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.",144.21,"99-66-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/valproic-acid.html","C8H16O2","free base","2-Propylvaleric Acid, Valproate","CCCC(CCC)C(O)=O",2.749,1,0,5]
["S3951","Tannic acid","g10","L2600-06","in 10mM DMSO","CXCR","Immunology & Inflammation","Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.",{"v":1701.2,"d":"1701.20"},"1401-55-4",{"v":100,"d":"100.00"},58.78,"N/A","N/A","http://selleckchem.com/products/tannic-acid.html","C76H52O46","free base","Gallotannic acid","OC1=CC(=CC(=C1O)O)C(=O)OC2=C(O)C(=CC(=C2)C(=O)OCC3OC(OC(=O)C4=CC(=C(O)C(=C4)O)OC(=O)C5=CC(=C(O)C(=C5)O)O)C(OC(=O)C6=CC(=C(O)C(=C6)O)OC(=O)C7=CC(=C(O)C(=C7)O)O)C(OC(=O)C8=CC(=C(O)C(=C8)O)OC(=O)C9=CC(=C(O)C(=C9)O)O)C3OC(=O)C%10=CC(=C(O)C(=C%10)O)OC(=O)C%11=CC(=C(O)C(=C%11)O)O)O",8.813,21,25,31]
["S3984","Nordihydroguaiaretic acid (NDGA)","h10","L2600-06","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase","Metabolism","Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.",302.36,"500-38-9",{"v":60,"d":"60.00"},198.44,"<1","N/A","http://selleckchem.com/products/nordihydroguaiaretic-acid.html","C18H22O4","free base","N/A","CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O",4.708,0,4,5]
["S4002","Sitagliptin phosphate monohydrate","a11","L2600-06","in 10mM DMSO","DPP","Metabolism","Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.",523.32,"654671-77-9",{"v":100,"d":"100.00"},191.09,{"v":41,"d":"41.00"},78.35,"https://www.selleckchem.com/products/sitagliptin-phosphate-monohydrate.html","C16H15F6N5O.H3PO4.H2O","phosphate &monohydrate","MK-0431","O.NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F.O[P](O)(O)=O",1.254,3,1,5]
["S4003","Lithocholic acid","b11","L2600-06","in 10mM DMSO","FXR","Metabolism","Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.",376.57,"434-13-9",{"v":75,"d":"75.00"},199.17,"<1","N/A","http://selleckchem.com/products/lithocholic-acid.html","C24H40O3","free base","N/A","CC(CCC(O)=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C",5.184,1,1,4]
["S4022","Probenecid","c11","L2600-06","in 10mM DMSO","Taste Receptor,TRP Channel","Transmembrane Transporters","Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.",285.36,"57-66-9",{"v":57,"d":"57.00"},199.75,"<1","N/A","http://selleckchem.com/products/probenecid-benemid.html","C13H19NO4S","free base","Benemid","CCCN(CCC)[S](=O)(=O)C1=CC=C(C=C1)C(O)=O",2.321,3,0,7]
["S4054","Spironolactone","d11","L2600-06","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.",416.57,"52-01-7",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/spironolactone.html","C24H32O4S","free base","N/A","CC(=O)SC1CC2=CC(=O)CCC2(C)C3CCC4(C)C(CCC45CCC(=O)O5)C13",3.731,4,0,2]
["S4059","Sodium Nitroprusside Dihydrate","e11","L2600-06","in 10mM DMSO","Others","Others","Sodium Nitroprusside  Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.",297.95,"13755-38-9",{"v":60,"d":"60.00"},201.38,{"v":60,"d":"60.00"},201.38,"http://selleckchem.com/products/sodium-nitroprusside-dihydrate.html","C5H4FeN6Na2O3","Dihydrate","N/A","[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N",0.571,1,0,1]
["S4060","Erythromycin Ethylsuccinate","f11","L2600-06","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.",862.05,"1264-62-6",{"v":172,"d":"172.00"},199.52,"<1","N/A","http://selleckchem.com/products/erythromycin-ethylsuccinate.html","C43H75NO16","free base","N/A","CCOC(=O)CCC(=O)OC1C(CC(C)OC1OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)N(C)C",2.591,12,2,14]
["S4061","Levobupivacaine HCl","g11","L2600-06","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Levobupivacaine HCl ((S)-(-)-Bupivacaine), the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.",324.89,"27262-48-2",{"v":64,"d":"64.00"},196.99,{"v":64,"d":"64.00"},196.99,"http://selleckchem.com/products/lvobupivacaine-hcl.html","C18H28N2O.HCl","Hydrochloride","(S)-(-)-Bupivacaine HCl","Cl.CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.692,1,1,5]
["S4070","Guanidine HCl","h11","L2600-06","in 10mM DMSO","Others","Others","Guanidine HCl (Aminoformamidine), the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.",95.53,"50-01-1",{"v":19,"d":"19.00"},198.89,{"v":19,"d":"19.00"},198.89,"http://selleckchem.com/products/guanidine-aminoformamidine-hcl.html","CH5N3.HCl","Hydrochloride","Aminoformamidine HCl","Cl.NC(N)=N",-0.606,0,2,0]
["S4076","Propranolol HCl","a2","L2600-07","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.",{"v":295.8,"d":"295.80"},"318-98-9",{"v":59,"d":"59.00"},199.46,{"v":6,"d":"6.00"},20.28,"http://selleckchem.com/products/propranolol-hcl.html","C16H21NO2.HCl","Hydrochloride","AY-64043, ICI-45520, NCS-91523","Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12",2.922,1,2,6]
["S4081","Sulfacetamide Sodium","b2","L2600-07","in 10mM DMSO","Anti-infection,Autophagy","Immunology & Inflammation","Sulfacetamide Sodium is an anti-biotic.",236.22,"127-56-0",{"v":19,"d":"19.00"},80.43,{"v":51,"d":"51.00"},{"v":215.9,"d":"215.90"},"http://selleckchem.com/products/sulfacetamide-sodium.html","C8H10N2O3S.Na","Sodium Salt","N/A","[Na+].CC(=O)[N-][S](=O)(=O)C1=CC=C(N)C=C1",-0.118,3,1,2]
["S4100","Esmolol HCl","c2","L2600-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.",331.83,"81161-17-3",{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},"http://selleckchem.com/products/esmolol-hcl.html","C16H25NO4.HCl","Hydrochloride","ASL8052","Cl.COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1",{"v":2.36,"d":"2.360"},3,2,10]
["S4125","Sodium Phenylbutyrate","d2","L2600-07","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.",187.19,"1716-12-7",{"v":8,"d":"8.00"},42.97,{"v":30,"d":"30.00"},161.13,"http://selleckchem.com/products/sodium-phenylbutyrate.html","C10H11O2.Na","Sodium Salt","4-PBA, 4-Phenylbutyric acid, NaPB","[Na]OC(=O)CCCC1=CC=CC=C1",2.497,2,0,5]
["S4136","Carprofen","e2","L2600-07","in 10mM DMSO","COX","Neuronal Signaling","Carprofen inhibits canine COX2 with IC50 of 30 nM.",273.71,"53716-49-7",{"v":55,"d":"55.00"},200.94,"<1","N/A","http://selleckchem.com/products/carprofen.html","C15H12ClNO2","free base","N/A","CC(C(O)=O)C1=CC2=C(C=C1)C3=C([NH]2)C=CC(=C3)Cl",4.114,1,1,2]
["S4151","Penfluridol","f2","L2600-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.",523.97,"26864-56-2",{"v":100,"d":"100.00"},190.85,"<1","N/A","http://selleckchem.com/products/penfluridol.html","C28H27ClF5NO","free base","TLP-607,R-16341","OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(=C(Cl)C=C4)C(F)(F)F",7.311,0,0,8]
["S4175","Sulfaguanidine","g2","L2600-07","in 10mM DMSO","Anti-infection","Microbiology","Sulfaguanidine is a sulfonamide used as an anti-infective agent.",214.24,"57-67-0",{"v":43,"d":"43.00"},200.71,"<1","N/A","http://selleckchem.com/products/sulfaguanidine.html","C7H10N4O2S","free base","N/A","NC(=N)N[S](=O)(=O)C1=CC=C(N)C=C1",-0.377,2,3,3]
["S4181","Nicardipine HCl","h2","L2600-07","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.",515.99,"54527-84-3",{"v":100,"d":"100.00"},{"v":193.8,"d":"193.80"},"<1","N/A","http://selleckchem.com/products/nicardipine-hcl.html","C26H29N3O6.HCl","Hydrochloride","RS-69216,YC-93","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",{"v":3.87,"d":"3.870"},4,1,11]
["S4206","Cysteamine HCl","a3","L2600-07","in 10mM DMSO","Antioxidant","Metabolism","Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.",113.61,"156-57-0",{"v":23,"d":"23.00"},202.45,{"v":23,"d":"23.00"},202.45,"http://selleckchem.com/products/cysteamine-hcl.html","C2H7NS.HCl","Hydrochloride","Mercaptamine","Cl.NCCS",0.166,0,1,1]
["S4223","Mevastatin","b3","L2600-07","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.",390.51,"73573-88-3",{"v":78,"d":"78.00"},199.74,"<1","N/A","http://selleckchem.com/products/mevastatin.html","C23H34O5","free base","ML-236B,Compactin","CCC(C)C(=O)OC1CCC=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",3.966,4,1,7]
["S4238","Cepharanthine","c3","L2600-07","in 10mM DMSO","TNF-alpha","Apoptosis","Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.",606.71,"481-49-2",{"v":100,"d":"100.00"},164.82,"<1","N/A","http://selleckchem.com/products/cepharanthine.html","C37H38N2O6","free base","NSC-623442","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C(=C6OCOC6=C5)OC7=C(OC)C=C8CCN(C)C(CC(=C2)C=C1)C8=C7)C=C3",7.019,6,0,2]
["S4239","Bergapten","d3","L2600-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.",216.19,"484-20-8",{"v":5,"d":"5.00"},23.13,"<1","N/A","http://selleckchem.com/products/bergapten.html","C12H8O4","free base","N/A","COC1=C2C=COC2=CC3=C1C=CC(=O)O3",2.187,4,0,1]
["S4255","Quinacrine 2HCl","e3","L2600-07","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective  phospholipase A2 inhibitor.",472.88,"69-05-6",{"v":14,"d":"14.00"},29.61,{"v":53,"d":"53.00"},112.08,"http://selleckchem.com/products/quinacrine-2hcl.html","C23H30ClN3O.2HCl","Dihydrochloride","Quinacrine dihydrochloride","Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",{"v":6.43,"d":"6.430"},2,1,9]
["S4260","Tamibarotene","f3","L2600-07","in 10mM DMSO","Retinoid Receptor","Metabolism","Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.",351.44,"94497-51-5",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://selleckchem.com/products/tamibarotene.html","C22H25NO3","free base","Am 80","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S4269","Vinorelbine ditartrate (KW-2307)","g3","L2600-07","in 10mM DMSO","Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.",1079.11,"125317-39-7",{"v":100,"d":"100.00"},92.67,{"v":100,"d":"100.00"},92.67,"http://selleckchem.com/products/vinorelbine-tartrate.html","C45H54N4O8.2C4H6O6","ditartrate","Nor-5'-anhydrovinblastine ditartrate,KW-2307","CCC1=CC2CN(C1)CC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC.OC(C(O)C(O)=O)C(O)=O.OC(C(O)C(O)=O)C(O)=O",{"v":-4,"d":"-4.000"},11,5,16]
["S4294","Procainamide HCl","h3","L2600-07","in 10mM DMSO","DNA Methyltransferase,Sodium Channel","Transmembrane Transporters","Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.",271.79,"614-39-1",{"v":54,"d":"54.00"},198.68,{"v":54,"d":"54.00"},198.68,"http://selleckchem.com/products/procainamide-hcl.html","C13H22ClN3O","Hydrochloride","N/A","Cl.CCN(CC)CCNC(=O)C1=CC=C(N)C=C1",1.509,1,2,6]
["S4299","Dicoumarol","a4","L2600-07","in 10mM DMSO","PDHK","Metabolism","Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.",336.29,"66-76-2",{"v":67,"d":"67.00"},199.23,"<1","N/A","http://selleckchem.com/products/dicoumarol.html","C19H12O6","free base","Dicumarol","OC1=C(CC2=C(O)C3=C(OC2=O)C=CC=C3)C(=O)OC4=CC=CC=C14",2.789,4,2,2]
["S4309","Bromocriptine Mesylate","b4","L2600-07","in 10mM DMSO","Others","Others","Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.",{"v":750.7,"d":"750.70"},"22260-51-1",{"v":100,"d":"100.00"},133.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bromocriptine-mesylate.html","C32H40BrN5O5.CH4O3S","Mesylate","N/A","CC(C)CC1N2C(=O)C(NC(=O)C3CN(C)C4CC5=C(Br)[NH]C6=C5C(=CC=C6)C4=C3)(OC2(O)C7CCCN7C1=O)C(C)C.C[S](O)(=O)=O",3.949,4,2,5]
["S4345","Pentoxifylline","c4","L2600-07","in 10mM DMSO","PDE","Metabolism","Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.",278.31,"6493-05-6",{"v":55,"d":"55.00"},197.62,{"v":55,"d":"55.00"},197.62,"http://www.selleckchem.com/products/pentoxifylline.html","C13H18N4O3","Free Base","N/A","C[N]1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C",0.507,4,0,5]
["S4420","Mefloquine HCl","d4","L2600-07","in 10mM DMSO","Anti-infection","Microbiology","Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.",414.77,"51773-92-3",{"v":82,"d":"82.00"},{"v":197.7,"d":"197.70"},"<1","N/A","http://selleckchem.com/products/mefloquine-hcl.html","C17H17ClF6N2O","Hydrochloride","Mefloquin hydrochloride","Cl.OC(C1CCCCN1)C2=CC(=NC3=C(C=CC=C23)C(F)(F)F)C(F)(F)F",4.684,1,2,4]
["S4505","Vinblastine (NSC-49842) sulfate","e4","L2600-07","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1","N/A","http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4506","Acetazolamide","f4","L2600-07","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).",222.25,"59-66-5",{"v":44,"d":"44.00"},197.98,"<1","N/A","http://selleckchem.com/products/acetazolamide.html","C4H6N4O3S2","free base","Diamox","CC(=O)NC1=NN=C(S1)[S](N)(=O)=O",-1.329,5,2,2]
["S4512","Aceglutamide","g4","L2600-07","in 10mM DMSO","Others","Others","Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability.",188.18,"2490-97-3",{"v":37,"d":"37.00"},196.62,{"v":37,"d":"37.00"},196.62,"http://selleckchem.com/products/aceglutamide.html","C7H12N2O4","free base","α-N-Acetyl-L-glutamine, N2-Acetylglutamine","CC(=O)NC(CCC(N)=O)C(O)=O",-1.587,3,2,5]
["S4538","Pantoprazole sodium","h4","L2600-07","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",405.35,"138786-67-1",{"v":81,"d":"81.00"},199.83,{"v":81,"d":"81.00"},199.83,"http://selleckchem.com/products/pantoprazole-sodium.html","C16H14F2N3NaO4S","Free Base","SKF96022 sodium, BY-1023 sodium","[Na+].COC1=CC=NC(=C1OC)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F",2.883,6,0,7]
["S4539","Salicylic acid","a5","L2600-07","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1","N/A","http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4541","Triclosan","b5","L2600-07","in 10mM DMSO","Bacterial","Microbiology","Triclosan (Irgasan, Cloxifenolum) is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.",289.54,"3380-34-5",{"v":57,"d":"57.00"},196.86,"<1","N/A","http://selleckchem.com/products/triclosan.html","C12H7Cl3O2","free base","Irgasan, Cloxifenolum","OC1=CC(=CC=C1OC2=CC=C(Cl)C=C2Cl)Cl",5.141,1,1,2]
["S4543","Trimetazidine dihydrochloride","c5","L2600-07","in 10mM DMSO","FAO","Metabolism","Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.",339.26,"13171-25-0",{"v":67,"d":"67.00"},197.49,{"v":67,"d":"67.00"},197.49,"http://selleckchem.com/products/trimetazidine-dihydrochloride.html","C14H22N2O3.2HCl","Dihydrochloride","Yoshimilon, Kyurinett, Vastarel F","Cl.Cl.COC1=C(OC)C(=C(CN2CCNCC2)C=C1)OC",2.039,3,1,5]
["S4546","Xylitol","d5","L2600-07","in 10mM DMSO","Autophagy","Autophagy","Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.",152.15,"87-99-0",{"v":30,"d":"30.00"},197.17,{"v":30,"d":"30.00"},197.17,"http://selleckchem.com/products/xylitol.html","C5H12O5","free base","Adonitol, Ribitol, Xylite, D-Xylitol, Adonite","OCC(O)C(O)C(O)CO",{"v":-2.43,"d":"-2.430"},0,5,4]
["S4561","Danthron","e5","L2600-07","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.",240.21,"117-10-2",{"v":4,"d":"4.00"},16.65,"<1","N/A","http://selleckchem.com/products/danthron.html","C14H8O4","free base","chrysazin, Antrapurol","OC1=CC=CC2=C1C(=O)C3=C(O)C=CC=C3C2=O",2.324,2,2,0]
["S4576","Sulfabenzamide","f5","L2600-07","in 10mM DMSO","Bacterial","Microbiology","Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.",276.31,"127-71-9",{"v":55,"d":"55.00"},199.05,"<1","N/A","http://selleckchem.com/products/sulfabenzamide.html","C13H12N2O3S","free base","Sultrin, N-Sulfanilylbenzamide","NC1=CC=C(C=C1)[S](=O)(=O)NC(=O)C2=CC=CC=C2",1.442,3,2,3]
["S4585","Succinylsulfathiazole","g5","L2600-07","in 10mM DMSO","Antibiotics","Microbiology","Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.",355.39,"116-43-8",{"v":71,"d":"71.00"},199.78,"<1","N/A","http://selleckchem.com/products/succinylsulfathiazole.html","C13H13N3O5S2","free base","Succinylsulphathiazole","OC(=O)CCC(=O)NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CS2",{"v":0.28,"d":"0.280"},5,2,7]
["S4591","Nitroxoline","h5","L2600-07","in 10mM DMSO","Cathepsin B,Cysteine Protease","Proteases","Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.",190.16,"4008-48-4",{"v":38,"d":"38.00"},199.83,"<1","N/A","http://selleckchem.com/products/nitroxoline.html","C9H6N2O3","free base","8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline","OC1=CC=C(C2=CC=CN=C12)[N+]([O-])=O",1.668,1,1,1]
["S4601","Clioquinol","a6","L2600-07","in 10mM DMSO","Fungal","Microbiology","Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.",{"v":305.5,"d":"305.50"},"130-26-7",{"v":61,"d":"61.00"},199.67,"<1","N/A","http://selleckchem.com/products/5-chloro-8-hydroxy-7-iodoquinoline.html","C9H5ClINO","free base","Iodochlorhydroxyquin, Chinoform","OC1=C(I)C=C(Cl)C2=CC=CN=C12",3.016,1,1,0]
["S4627","TTNPB (Arotinoid Acid)","b6","L2600-07","in 10mM DMSO","Retinoid Receptor","Metabolism","TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.",348.48,"71441-28-6",{"v":15,"d":"15.00"},43.04,"<1","N/A","http://selleckchem.com/products/ttnpb-arotinoid-acid.html","C24H28O2","free base","Ro 13-7410, AGN-191183","CC(=C\\C1=CC=C(C=C1)C(O)=O)/C2=CC3=C(C=C2)C(C)(C)CCC3(C)C",6.321,1,0,3]
["S4630","Diazoxide","c6","L2600-07","in 10mM DMSO","ADC Cytotoxin,Potassium Channel","Transmembrane Transporters","Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.",230.67,"364-98-7",{"v":46,"d":"46.00"},199.42,"<1","N/A","http://selleckchem.com/products/diazoxide.html","C8H7ClN2O2S","free base","Sch-6783, SRG-95213, Proglycem","CC1=NC2=CC=C(Cl)C=C2[S](=O)(=O)N1",1.196,3,1,0]
["S4633","Isosorbide Mononitrate","d6","L2600-07","in 10mM DMSO","Others","Others","Isosorbide mononitrate (Elantan, Monoket, Mononit, Imdur, Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.",191.14,"16051-77-7",{"v":38,"d":"38.00"},198.81,{"v":38,"d":"38.00"},198.81,"http://selleckchem.com/products/isosorbide-mononitrate.html","C6H9NO6","Free Base","Isosorbide-5-mononitrate, Elantan, Monoket, Mononit, Imdur, Corangin","OC1COC2C(COC12)O[N+]([O-])=O",1.003,3,1,2]
["S4648","Dantrolene sodium hemiheptahydrate","e6","L2600-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.",399.29,"24868-20-0",{"v":14,"d":"14.00"},35.06,"<1","N/A","https://www.selleckchem.com/products/dantrolene-sodium-s4648.html","C14H9N4O5.7/2H2O.Na","Sodium salt hemiheptahydrate","Dantrolene sodium salt, Dantrium, Sodium dantrolene","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4685","Efavirenz","f6","L2600-07","in 10mM DMSO","Reverse Transcriptase","Microbiology","Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.",315.67,"154598-52-4",{"v":63,"d":"63.00"},199.58,"<1","N/A","http://selleckchem.com/products/efavirenz.html","C14H9ClF3NO2","free base","Sustiva, Stocrin, DMP-266, DMP 266","FC(F)(F)C1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC3CC3",4.381,2,1,3]
["S4711","Esculetin","g6","L2600-07","in 10mM DMSO","Lipoxygenase","Metabolism","Esculetin (Cichorigenin, Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).",178.14,"305-01-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/esculetin.html","C9H6O4","free base","Cichorigenin, Aesculetin","OC1=CC2=C(C=CC(=O)O2)C=C1O",1.415,2,2,0]
["S4722","(+)-Catechin","h6","L2600-07","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,",290.27,"154-23-4",{"v":58,"d":"58.00"},199.81,{"v":58,"d":"58.00"},199.81,"http://selleckchem.com/products/catechin.html","C15H14O6","free base","Cianidanol, Catechinic acid, Catechuic acid, Catechin","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4728","3,3'-Diindolylmethane","a7","L2600-07","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.",246.31,"1968-05-4",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/3-3-diindolylmethane.html","C17H14N2","free base","DIM","C(C1=C[NH]C2=C1C=CC=C2)C3=C[NH]C4=C3C=CC=C4",4.391,0,2,2]
["S4739","Oxyresveratrol","b7","L2600-07","in 10mM DMSO","Tyrosinase","Proteases","Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.",244.24,"29700-22-9",{"v":48,"d":"48.00"},196.53,{"v":1,"d":"1.00"},4.09,"http://selleckchem.com/products/oxyresveratrol.html","C14H12O4","free base","Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene","OC1=CC=C(\\C=C\\C2=CC(=CC(=C2)O)O)C(=C1)O",2.848,0,4,2]
["S4743","Wogonin","c7","L2600-07","in 10mM DMSO","CDK,Transferase","Cell Cycle","Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.",284.26,"632-85-9",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/wogonin.html","C16H12O5","free base","Vogonin","COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C3=CC=CC=C3",2.636,3,2,2]
["S4746","(20S)-Protopanaxadiol","d7","L2600-07","in 10mM DMSO","P-gp","Transmembrane Transporters","20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.",460.73,"30636-90-9",{"v":92,"d":"92.00"},199.68,"<1","N/A","http://selleckchem.com/products/20s-protopanaxadiol.html","C30H52O3","free base","20-Epiprotopanaxadiol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4CCC23C",5.789,0,2,4]
["S4749","Citalopram HBr","e7","L2600-07","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.",{"v":405.3,"d":"405.30"},"59729-32-7",{"v":81,"d":"81.00"},199.85,{"v":81,"d":"81.00"},199.85,"http://selleckchem.com/products/citalopram-hbr.html","C20H21FN2O.HBr","hydrobromide","Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr","Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C3=CC=C(F)C=C3",4.212,1,0,5]
["S4750","Sulfacetamide sodium salt hydrate","f7","L2600-07","in 10mM DMSO","Antibiotics,Autophagy,Bacterial","Autophagy","Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.",254.24,"6209-17-2",{"v":50,"d":"50.00"},196.66,{"v":50,"d":"50.00"},196.66,"http://selleckchem.com/products/sulfacetamide-sodium-salt-hydrate.html","C8H9N2O3S.H2O.Na","sodium salt hyd","N/A","O.CC(=O)N([Na])[S](=O)(=O)C1=CC=C(N)C=C1",-0.326,3,1,2]
["S4753","Ganoderic acid A","g7","L2600-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.",516.67,"81907-62-2",{"v":100,"d":"100.00"},193.55,"<1","N/A","http://selleckchem.com/products/ganoderic-acid-a.html","C30H44O7","free base","N/A","CC(CC(=O)CC(C)C(O)=O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C4(C)CCC(=O)C(C)(C)C4CC3O",2.775,4,2,6]
["S4783","Benzyl isothiocyanate","h7","L2600-07","in 10mM DMSO","Antibiotics","Microbiology","Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.",149.21,"622-78-6",{"v":29,"d":"29.00"},194.36,"N/A","N/A","http://selleckchem.com/products/benzyl-isothiocyanate.html","C8H7NS","free base","Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester","S=C=NCC1=CC=CC=C1",{"v":0,"d":"0.000"},0,0,0]
["S4785","Nicotinamide N-oxide","a8","L2600-07","in 10mM DMSO","CXCR","Immunology & Inflammation","Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the  CXCR2 receptor.",138.12,"1986-81-8",{"v":8,"d":"8.00"},57.92,"N/A","N/A","http://selleckchem.com/products/nicotinamide-n-oxide.html","C6H6N2O2","free base","Nicotinamide 1-oxide, 1-oxynicotinamide, 1-Oxy-nicotinamide","NC(=O)C1=CC=C[N+](=C1)[O-]",{"v":0,"d":"0.000"},0,0,0]
["S4900","Tenovin-6","b8","L2600-07","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.",454.63,"1011557-82-6",{"v":98,"d":"98.00"},215.56,{"v":98,"d":"98.00"},215.56,"http://selleckchem.com/products/tenovin-6.html","C25H34N4O2S","free base","N/A","Cl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",{"v":5.7,"d":"5.700"},2,3,11]
["S4901","JNK-IN-8","c8","L2600-07","in 10mM DMSO","JNK","MAPK","JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.",507.59,"1410880-22-6",{"v":100,"d":"100.00"},197.01,"<1","N/A","http://selleckchem.com/products/jnk-in-8.html","C29H29N7O2","free base","JNK Inhibitor XVI","CN(C)C/C=C/C(=O)NC1=CC(=CC=C1)C(=O)NC2=CC=C(NC3=NC=CC(=N3)C4=CC=CN=C4)C(=C2)C",3.997,5,3,9]
["S4908","SN-38","d8","L2600-07","in 10mM DMSO","ADC Cytotoxin,Autophagy,Topoisomerase","DNA Damage/DNA Repair","SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.",{"v":392.4,"d":"392.40"},"86639-52-3",{"v":21,"d":"21.00"},53.52,"<1","N/A","http://selleckchem.com/products/sn-38.html","C22H20N2O5","free base","NK012","CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=C1C=C(O)C=C5)C(O)(CC)C(=O)OC4",2.446,4,1,2]
["S4920","b-AP15","e8","L2600-07","in 10mM DMSO","DUB","Ubiquitin","b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.",419.39,"1009817-63-3",{"v":48,"d":"48.00"},114.45,"<1","N/A","http://selleckchem.com/products/b-ap15.html","C22H17N3O6","free base","NSC687852","[O-][N+](=O)C1=CC=C(C=C1)\\C=C2/CN(C\\C(=C/C3=CC=C(C=C3)[N+]([O-])=O)C2=O)C(=O)C=C",3.653,2,0,5]
["S4953","Usnic acid","f8","L2600-07","in 10mM DMSO","Akt,ERK","PI3K/Akt/mTOR","Usnic acid (Usniacin) is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. It exhibits antiviral, antiprotozoal, antiproliferative, anti-inflammatory and analgesic activity. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways.",344.32,"125-46-2",{"v":4,"d":"4.00"},11.62,"N/A","N/A","http://selleckchem.com/products/usnic-acid.html","C18H16O7","free base","Usniacin","CC(=O)C1C(=O)C=C2OC3=C(C(=C(C)C(=C3C(C)=O)O)O)C2(C)C1=O",1.084,5,2,2]
["S4959","Skatole","g8","L2600-07","in 10mM DMSO","Bacterial","Microbiology","Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.",131.17,"83-34-1",{"v":26,"d":"26.00"},198.22,"N/A","N/A","http://selleckchem.com/products/skatole.html","C9H9N","Indoles","3-methylindole, Scatole","CC1=C[NH]C2=C1C=CC=C2",2.609,0,1,0]
["S4976","Sulfalene (SMPZ)","h8","L2600-07","in 10mM DMSO","Others","Others","Sulfalene (SMPZ, Butadiene sulfone, 3-Sulfolene) is a cyclic organic chemical used as a versatile synthetic intermediate.",{"v":280.3,"d":"280.30"},"152-47-6",{"v":56,"d":"56.00"},199.79,"<1","N/A","http://selleckchem.com/products/sulfalene-smpz.html","C11H12N4O3S","free base","Butadiene sulfone, 3-Sulfolene","COC1=C(N[S](=O)(=O)C2=CC=C(N)C=C2)N=CC=N1",0.331,5,2,4]
["S4978","Azathramycin","a9","L2600-07","in 10mM DMSO","Antibiotics","Microbiology","Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.",734.96,"76801-85-9",{"v":50,"d":"50.00"},68.03,"<1","N/A","http://selleckchem.com/products/azathramycin.html","C37H70N2O12","Macrolide antibiotics","Azaerythromycin A, Azaerythromycin","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CNC(C)C(O)C1(C)O",1.542,7,4,7]
["S4990","TBHQ","b9","L2600-07","in 10mM DMSO","Nrf2","Immunology & Inflammation","Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.",166.22,"1948-33-0",{"v":33,"d":"33.00"},198.53,"N/A","N/A","http://selleckchem.com/products/tbhq.html","C10H14O2","free base","Tert-butylhydroquinone","CC(C)(C)C1=C(O)C=CC(=C1)O",2.746,0,2,1]
["S4998","2-Aminobenzenesulfonamide","c9","L2600-07","in 10mM DMSO","Carbonic Anhydrase","Metabolism","2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.",{"v":172.2,"d":"172.20"},"3306-62-5",{"v":34,"d":"34.00"},197.44,"N/A","N/A","https://www.selleckchem.com/products/2-aminobenzenesulfonamide.html","C6H8N2O2S","Sulfonamides","Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide","NC1=CC=CC=C1[S](N)(=O)=O",-0.212,2,2,1]
["S4999","Avermectin B1","d9","L2600-07","in 10mM DMSO","Parasite","Microbiology","Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.",873.08,"71751-41-2",{"v":100,"d":"100.00"},114.54,"N/A","N/A","http://selleckchem.com/products/avermectin.html","C48H72O14","Macrocyclic lactones","abamectin","CCC(C)C1OC2(CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2)C=CC1C",4.692,11,2,8]
["S5003","Tacrolimus (FK506)","e9","L2600-07","in 10mM DMSO","Autophagy,FKBP,phosphatase","PI3K/Akt/mTOR","Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.",804.02,"104987-11-3",{"v":94,"d":"94.00"},116.91,"<1","N/A","http://selleckchem.com/products/FK-506-(Tacrolimus).html","C44H69NO12","free base","FK506, FR900506, Fujimycin, Prograf","COC1CC(CCC1O)\\C=C(C)\\C2OC(=O)C3CCCCN3C(=O)C(=O)C4(O)OC(C(CC(C)C/C(=C/C(CC=C)C(=O)CC(O)C2C)C)OC)C(CC4C)OC",4.832,9,2,7]
["S5066","Pramipexole dihydrochloride","f9","L2600-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.",284.25,"104632-25-9",{"v":56,"d":"56.00"},197.01,"N/A","N/A","http://selleckchem.com/products/pramipexole-dihydrochloride.html","C10H17N3S.2HCl","dihydrochloride","SND919","Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",2.147,1,2,3]
["S5069","Dabrafenib Mesylate","g9","L2600-07","in 10mM DMSO","Raf","MAPK","Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.8 nM, 3.2 nM and 5 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.",615.67,"1195768-06-9",{"v":100,"d":"100.00"},162.42,"<1","N/A","http://selleckchem.com/products/dabrafenib-mesylate.html","C23H20F3N5O2S2.CH4O3S","mesylate","GSK2118436 Mesylate","CC(C)(C)C1=NC(=C(S1)C2=CC=NC(=N2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F.C[S](O)(=O)=O",4.963,5,2,6]
["S5077","Regorafenib (BAY-734506) Monohydrate","h9","L2600-07","in 10mM DMSO","c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, Kit (c-Kit), RET (c-RET), RAF-1, B-RAF and B-RAF(V600E) respectively.",500.83,"1019206-88-2",{"v":100,"d":"100.00"},199.67,"N/A","N/A","http://selleckchem.com/products/regorafenib-monohydrate.html","C21H15ClF4N4O3.H2O","monohydrate","Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate","O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F",4.174,4,3,6]
["S5079","Sitagliptin","a10","L2600-07","in 10mM DMSO","DPP","Proteases","Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.",407.31,"486460-32-6",{"v":81,"d":"81.00"},198.87,"N/A","N/A","http://selleckchem.com/products/sitagliptin.html","C16H15F6N5O","free base","MK-0431","NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F",{"v":1.93,"d":"1.930"},3,1,5]
["S5144","Neferine","b10","L2600-07","in 10mM DMSO","Akt,Apoptosis related,Autophagy,HIV,NF-κB,Nrf2","NF-κB","Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.",624.77,"2292-16-2",{"v":100,"d":"100.00"},160.06,"N/A","N/A","http://selleckchem.com/products/neferine.html","C38H44N2O6","free base","(R)-1,2-Dimethoxyaporphine","COC1=CC=C(CC2N(C)CCC3=C2C=C(OC4=CC(=CC=C4O)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C(=C3)OC)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5177","Naproxen","c10","L2600-07","in 10mM DMSO","COX","Immunology & Inflammation","Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.",230.26,"22204-53-1",{"v":46,"d":"46.00"},199.77,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/naproxen.html","C14H14O3","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(O)=O",2.849,2,0,3]
["S5182","GSK4112","d10","L2600-07","in 10mM DMSO","Others","Metabolism","GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes.",396.89,"1216744-19-2",{"v":68,"d":"68.00"},171.33,{"v":1,"d":"1.00"},2.52,"http://www.selleckchem.com/products/gsk4112.html","C18H21ClN2O4S","Free Base","N/A","CC(C)(C)OC(=O)CN(CC1=CC=C(S1)[N+]([O-])=O)CC2=CC=C(Cl)C=C2",4.548,2,0,9]
["S5233","Fenretinide (NSC 374551)","e10","L2600-07","in 10mM DMSO","Retinoid Receptor","Metabolism","Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.",391.55,"65646-68-6",{"v":78,"d":"78.00"},199.21,"<1","N/A","http://selleckchem.com/products/fenretinide.html","C26H33NO2","free base","4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(=O)NC2=CC=C(O)C=C2)C(C)(C)CCC1",6.463,1,2,6]
["S5242","Cediranib Maleate","f10","L2600-07","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Cediranib Maleate (AZD-2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.",566.58,"857036-77-2",{"v":100,"d":"100.00"},{"v":176.5,"d":"176.50"},"<1","N/A","http://selleckchem.com/products/cediranib-maleate.html","C25H27FN4O3.C4H4O4","maleate","AZD-2171 maleate","COC1=CC2=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)N=CN=C2C=C1OCCCN5CCCC5.OC(=O)\\C=C/C(O)=O",1.765,7,1,10]
["S5243","Ruxolitinib Phosphate","g10","L2600-07","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",404.36,"1092939-17-7",{"v":80,"d":"80.00"},197.84,{"v":29,"d":"29.00"},71.72,"http://selleckchem.com/products/ruxolitinib-phosphate.html","C17H18N6.H3O4P","phosphate","INCB018424, INC424","O[P](O)(O)=O.N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",2.412,3,1,4]
["S5254","Dasatinib hydrochloride","h10","L2600-07","in 10mM DMSO","Bcr-Abl,kit,Src","Angiogenesis","Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.",524.47,"854001-07-3",{"v":100,"d":"100.00"},190.67,{"v":11,"d":"11.00"},20.97,"https://www.selleckchem.com/products/dasatinib-hydrochloride.html","C22H27Cl2N7O2S","hydrochloride","BMS-354825 HCl","Cl.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.821,4,3,7]
["S5284","Adenosine 5'-monophosphate monohydrate","a11","L2600-07","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).",365.24,"18422-05-4",{"v":9,"d":"9.00"},24.64,"N/A","N/A","http://selleckchem.com/products/adenosine-5-monophosphate-monohydrate.html","C10H14N5O7P.H2O","hydrate","5'-Adenylic acid, 5'-AMP","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O",{"v":-2.16,"d":"-2.160"},5,3,4]
["S5312","Urolithin A","b11","L2600-07","in 10mM DMSO","Mitophagy","Autophagy","Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.",{"v":228.2,"d":"228.20"},"1143-70-0",{"v":45,"d":"45.00"},{"v":197.2,"d":"197.20"},"<1","N/A","http://selleckchem.com/products/urolithin-a.html","C13H8O4","free base","3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin","OC1=CC=C2C(=C1)OC(=O)C3=CC(=CC=C23)O",2.466,2,2,0]
["S5313","SC66","c11","L2600-07","in 10mM DMSO","Akt","PI3K/Akt/mTOR","SC66 is an allosteric inhibitor which displays a dual-inhibitory function toward AKT activity with IC50 values of 0.77, 2.85 and 0.47 μg/ml in HepG2, Huh7 and Hep3B cells after 72 h treatment, respectively.",276.33,"871361-88-5",{"v":55,"d":"55.00"},199.04,"N/A","N/A","http://selleckchem.com/products/sc66.html","C18H16N2O","free base","N/A","O=C1C(/CCC\\C1=C/C2=CC=NC=C2)=C/C3=CC=NC=C3",2.836,3,0,2]
["S5327","Meisoindigo","d11","L2600-07","in 10mM DMSO","Others","Apoptosis","Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).",276.29,"97207-47-1",{"v":55,"d":"55.00"},199.07,"<1","N/A","http://selleckchem.com/products/meisoindigo.html","C17H12N2O2","free base","N-Methylisoindigotin, Methylisoindigotin, Dian III","CN1C(=O)/C(C2=C1C=CC=C2)=C3/C(=O)NC4=CC=CC=C34",1.851,2,1,0]
["S5329","FAAH-IN-2","e11","L2600-07","in 10mM DMSO","FAAH","Metabolism","FAAH-IN-2 is an inhibitor of fatty acid amide hydrolase (FAAH).",319.72,"184475-71-6",{"v":40,"d":"40.00"},125.11,"<1","N/A","http://selleckchem.com/products/faah-in-2.html","C15H11ClFN3O2","free base","N/A","COC1=C(O)C=C2C(=NC=NC2=C1)NC3=CC=C(F)C(=C3)Cl",4.088,3,2,3]
["S5373","Pseudolaric Acid B","f11","L2600-07","in 10mM DMSO","Fungal","Microbiology","Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.",432.46,"82508-31-4",{"v":86,"d":"86.00"},198.86,"<1","N/A","https://www.selleckchem.com/products/pseudolaric-acid-b.html","C23H28O8","Diterpenoids","N/A","COC(=O)C1=CCC23CCC(C(C)(OC2=O)\\C=C\\C=C(C)\\C(O)=O)C3(CC1)OC(C)=O",2.793,7,0,7]
["S5383","Erucic acid","g11","L2600-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Erucic acid (cis-13-docosenoic acid) is a monounsaturated omega-9 fatty acid used as mineral oil and a precursor to biodiesel fuel.",338.57,"112-86-7",{"v":67,"d":"67.00"},197.89,"N/A","N/A","http://selleckchem.com/products/erucic-acid.html","C22H42O2","free base","cis-13-docosenoic acid","CCCCCCCC\\C=C/CCCCCCCCCCCC(O)=O",8.685,1,0,19]
["S5394","Tizoxanide","h11","L2600-07","in 10mM DMSO","HCV Protease","Microbiology","Tizoxanide (Desacetyl-nitazoxanide), a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C.",265.25,"173903-47-4",{"v":27,"d":"27.00"},101.79,"<1","N/A","http://selleckchem.com/products/tizoxanide.html","C10H7N3O4S","free base","Desacetyl-nitazoxanide","OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.388,2,2,3]
["S5416","Metyrapone","a2","L2600-08","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.",226.27,"54-36-4",{"v":46,"d":"46.00"},203.29,{"v":-1,"d":"-1.00"},-4.42,"https://www.selleckchem.com/products/metyrapone.html","C14H14N2O","free base","NSC-25265, SU-4885","CC(C)(C1=CC=CN=C1)C(=O)C2=CC=CN=C2",1.847,3,0,3]
["S5450","Sofalcone","b2","L2600-08","in 10mM DMSO","Others","Others","Sofalcone (SU-88) is an antiulcer drug and a mucosal protective agent, increasing vascular endothelual growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.",450.52,"64506-49-6",{"v":90,"d":"90.00"},199.77,{"v":-1,"d":"-1.00"},-2.22,"https://www.selleckchem.com/products/sofalcone.html","C27H30O6","free base","SU-88","CC(C)=CCOC1=CC=C(/C=C/C(=O)C2=C(OCC(O)=O)C=C(OCC=C(C)C)C=C2)C=C1",6.065,5,0,12]
["S5451","Ferulic acid methyl ester","c2","L2600-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid,  which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.",208.21,"2309-07-1",{"v":41,"d":"41.00"},196.92,{"v":41,"d":"41.00"},196.92,"http://selleckchem.com/products/ferulic-acid-methylester.html","C11H12O4","free base","Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate","COC(=O)\\C=C\\C1=CC=C(O)C(=C1)OC",1.894,3,1,4]
["S5452","Sanguinarine chloride","d2","L2600-08","in 10mM DMSO","phosphatase,ROS","Immunology & Inflammation","Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.",367.78,"5578-73-4",{"v":5,"d":"5.00"},{"v":13.6,"d":"13.60"},"<1","N/A","http://selleckchem.com/products/sanguinarine-chloride.html","C20H14NO4.Cl","chloride","N/A","[Cl-].C[N+]1=CC2=C3OCOC3=CC=C2C4=CC=C5C=C6OCOC6=CC5=C14",1.313,4,0,0]
["S5456","Isobavachalcone","e2","L2600-08","in 10mM DMSO","Bacterial","Microbiology","Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.",324.37,"20784-50-3",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/isobavachalcone.html","C20H20O4","free base","Corylifolinin","CC(C)=CCC1=C(O)C(=CC=C1O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.832,1,3,5]
["S5466","Saikosaponin A","f2","L2600-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.",780.98,"20736-09-8",{"v":100,"d":"100.00"},128.04,"<1","N/A","https://www.selleckchem.com/products/saikosaponin-a.html","C42H68O13","free base","N/A","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O",1.107,5,8,6]
["S5478","Dantrolene sodium","g2","L2600-08","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.",336.23,"14663-23-1",{"v":67,"d":"67.00"},199.27,{"v":-1,"d":"-1.00"},-2.97,"https://www.selleckchem.com/products/s5478-dantrolene-sodium.html","C14H9N4NaO5","free base","F 440","[Na+].[O-]C1=NC(=O)CN1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+]([O-])=O",1.769,4,0,4]
["S5529","Galangin","h2","L2600-08","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.",270.24,"548-83-4",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/galangin.html","C15H10O5","free base","3,5,7-trihydroxyflavone; Norizalpinin","OC1=CC2=C(C(=C1)O)C(=O)C(=C(O2)C3=CC=CC=C3)O",2.114,2,3,1]
["S5554","Lanatoside C","a3","L2600-08","in 10mM DMSO","Akt,Antiviral,Apoptosis related,Autophagy,JAK,mTOR,PI3K,STAT,Wnt/beta-catenin","Immunology & Inflammation","Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.",985.12,"17575-22-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/lanatoside-c.html","C49H76O20","free base","N/A","CC1OC(CC(O)C1OC2CC(O)C(OC3CC(OC(C)=O)C(OC4OC(CO)C(O)C(O)C4O)C(C)O3)C(C)O2)OC5CCC6(C)C(CCC7C6CC(O)C8(C)C(CCC78O)C9=CC(=O)OC9)C5",0.631,12,7,12]
["S5563","Thioridazine hydrochloride","b3","L2600-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Thioridazine (Aldazine, Mellaril) is a potent antianxiety and antipsychotic agent.",407.04,"130-61-0",{"v":81,"d":"81.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/thioridazine-hydrochloride.html","C21H26N2S2.HCl","hydrochloride","Aldazine, Mellaril","Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC4CCCCN4C)C=C1",5.945,0,0,4]
["S5565","Triflupromazine hydrochloride","c3","L2600-08","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class.",388.88,"1098-60-8",{"v":78,"d":"78.00"},200.58,"N/A","N/A","https://www.selleckchem.com/products/triflupromazine-hydrochloride.html","C18H20ClF3N2S","salt","Fluopromazine hydrochloride","Cl.CN(C)CCCN1C2=C(SC3=CC=C(C=C13)C(F)(F)F)C=CC=C2",5.399,0,0,5]
["S5582","Cytarabine hydrochloride","d3","L2600-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.",279.68,"69-74-9",{"v":55,"d":"55.00"},196.65,"N/A","N/A","http://selleckchem.com/products/cytarabine-hydrochloride.html","C9H13N3O5.HCl","hydrochloride","N/A","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.014,3,4,2]
["S5627","Amsacrine hydrochloride","e3","L2600-08","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.",429.92,"54301-15-4",{"v":85,"d":"85.00"},197.71,"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/amsacrine-hydrochloride.html","C21H20ClN3O3S","free base","m-AMSA, acridinyl anisidide","Cl.COC1=CC(=CC=C1NC2=C3C=CC=CC3=NC4=C2C=CC=C4)N[S](C)(=O)=O",{"v":4.18,"d":"4.180"},4,2,5]
["S5658","Omeprazole Sodium","f3","L2600-08","in 10mM DMSO","P450 (e.g. CYP17),Proton Pump","Transmembrane Transporters","Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.",{"v":367.4,"d":"367.40"},"95510-70-6",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://www.selleckchem.com/products/omeprazole-sodium.html","C17H18N3NaO3S","Sodium Salt","N/A","COC1=CC2=C(C=C1)[N]([Na])C(=N2)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S5710","Ambroxol","g3","L2600-08","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.",{"v":378.1,"d":"378.10"},"18683-91-5",{"v":76,"d":"76.00"},{"v":201,"d":"201.00"},{"v":-1,"d":"-1.00"},-2.64,"https://www.selleckchem.com/products/ambroxol.html","C13H18Br2N2O","Expectorant","N/A","NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",2.739,0,3,3]
["S5715","Atorvastatin","h3","L2600-08","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.",558.64,"134523-00-5",{"v":100,"d":"100.00"},179.01,"<1","N/A","http://www.selleckchem.com/products/atorvastatin.html","C33H35FN2O5","Free Base","N/A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC(O)=O)C3=CC=C(F)C=C3)C4=CC=CC=C4",5.555,2,3,12]
["S5742","Deferoxamine mesylate (Ba 33112)","a4","L2600-08","in 10mM DMSO","Autophagy,Beta Amyloid,Ferroptosis,HIF","Autophagy","Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.",656.79,"138-14-7",{"v":100,"d":"100.00"},152.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/deferoxamine-mesylate.html","C26H52N6O11S","mesylate","Desferrioxamine B, DFOM, NSC 644468","CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.C[S](O)(=O)=O",-1.304,5,3,23]
["S5767","Aliskiren","b4","L2600-08","in 10mM DMSO","RAAS","Metabolism","Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.",551.76,"173334-57-1",{"v":100,"d":"100.00"},181.24,{"v":6,"d":"6.00"},10.87,"http://www.selleckchem.com/products/aliskiren.html","C30H53N3O6","Free Base","CGP 60536","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C",3.327,5,4,19]
["S5771","Sulforaphane","c4","L2600-08","in 10mM DMSO","HDAC,Heme Oxygenase,NF-κB,Nrf2,ROS","Immunology & Inflammation","Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,",177.29,"4478-93-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/sulforaphane.html","C6H11NOS2","Free Base","N/A","C[S](=O)CCCCN=C=S",1.157,2,0,5]
["S5787","Dronedarone","d4","L2600-08","in 10mM DMSO","Adrenergic Receptor","Transmembrane Transporters","Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).",556.76,"141626-36-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/dronedarone.html","C31H44N2O5S","Free Base","SR33589","CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=C2C=C(N[S](C)(=O)=O)C=C3",7.015,5,1,18]
["S5791","Cyclic Pifithrin-α hydrobromide","e4","L2600-08","in 10mM DMSO","p53","Apoptosis","Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.",349.29,"511296-88-1",{"v":27,"d":"27.00"},{"v":77.3,"d":"77.30"},{"v":1,"d":"1.00"},2.86,"http://www.selleckchem.com/products/cyclic-pifithrin-hydrobromide.html","C16H17BrN2S","hydrobromide","N/A","Br.CC1=CC=C(C=C1)C2=C[N]3C(=N2)SC4=C3CCCC4",4.616,1,0,1]
["S5792","CID 2011756","f4","L2600-08","in 10mM DMSO","PKD","GPCR & G Protein","CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.",396.87,"638156-11-3",{"v":30,"d":"30.00"},75.59,{"v":1,"d":"1.00"},2.52,"http://www.selleckchem.com/products/cid-2011756.html","C22H21ClN2O3","Free Base","N/A","ClC1=CC(=CC=C1)C2=CC=C(O2)C(=O)NC3=CC=C(CN4CCOCC4)C=C3",4.245,3,1,5]
["S5793","Motesanib (AMG-706)","g4","L2600-08","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively.",373.45,"453562-69-1",{"v":75,"d":"75.00"},200.83,{"v":1,"d":"1.00"},2.68,"http://www.selleckchem.com/products/motesanib-amg-706.html","C22H23N5O","Free Base","N/A","CC1(C)CNC2=CC(=CC=C12)NC(=O)C3=C(NCC4=CC=NC=C4)N=CC=C3",2.721,3,3,5]
["S5811","Kevetrin hydrochloride","h4","L2600-08","in 10mM DMSO","p53","Apoptosis","Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.",179.67,"66592-89-0",{"v":36,"d":"36.00"},200.37,{"v":36,"d":"36.00"},200.37,"http://www.selleckchem.com/products/kevetrin-hydrochloride.html","C5H10ClN3S","hydrochloride","Thioureidobutyronitrile HCl","Cl.NC(=N)SCCCC#N",1.105,0,1,4]
["S5818","acalisib (GS-9820)","a5","L2600-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.",{"v":401.4,"d":"401.40"},"870281-34-8",{"v":80,"d":"80.00"},{"v":199.3,"d":"199.30"},{"v":1,"d":"1.00"},2.49,"http://www.selleckchem.com/products/acalisib-gs-9820.html","C21H16FN7O","Free Base","CAL-120","CC(NC1=NC=NC2=C1[NH]C=N2)C3=NC4=C(C=C(F)C=C4)C(=O)N3C5=CC=CC=C5",3.097,5,2,4]
["S5829","Monomyristin","b5","L2600-08","in 10mM DMSO","Fungal","Microbiology","Monomyristin (Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate), a monoacylglyceride, shows high antibacterial and antifungal activities.",302.45,"589-68-4",{"v":60,"d":"60.00"},198.38,{"v":1,"d":"1.00"},3.31,"http://www.selleckchem.com/products/monomyristin.html","C17H34O4","Free Base","Glyceryl myristate; 2,3-Dihydroxypropyl tetradecanoate","CCCCCCCCCCCCCC(=O)OCC(O)CO",4.656,2,2,16]
["S5842","Cabergoline","c5","L2600-08","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.",{"v":451.6,"d":"451.60"},"81409-90-7",{"v":90,"d":"90.00"},199.29,{"v":1,"d":"1.00"},2.21,"http://www.selleckchem.com/products/cabergoline.html","C26H37N5O2","Free Base","FCE-21336","CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=C[NH]C4=C3C2=CC=C4)N(CC=C)C1",3.036,2,2,8]
["S5916","GSK 5959","d5","L2600-08","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.",394.47,"901245-65-6",{"v":6,"d":"6.00"},15.21,"<1","N/A","http://www.selleckchem.com/products/gsk-5959.html","C22H26N4O3","Free Base","N/A","COC1=CC=CC=C1C(=O)NC2=C(C=C3N(C)C(=O)N(C)C3=C2)N4CCCCC4",2.952,3,1,4]
["S5920","CA-5f","e5","L2600-08","in 10mM DMSO","Autophagy","Autophagy","CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.",388.46,"1370032-19-1",{"v":78,"d":"78.00"},200.79,{"v":1,"d":"1.00"},2.57,"http://www.selleckchem.com/products/ca-5f.html","C24H24N2O3","Free Base","N/A","COC1=CC=C(\\C=C2/CN(C)C\\C(=C/C3=C[NH]C4=C3C=CC=C4)C2=O)C=C1OC",4.168,3,1,4]
["S5932","BIA 10-2474","f5","L2600-08","in 10mM DMSO","FAAH","Metabolism","BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.",300.36,"1233855-46-3",{"v":4,"d":"4.00"},13.32,"<1","N/A","http://www.selleck.cn/products/bia-10-2474.html","C16H20N4O2","Free Base","N/A","CN(C1CCCCC1)C(=O)[N]2C=NC(=C2)C3=CC=C[N+](=C3)[O-]",1.719,2,0,2]
["S6005","VX-702","g5","L2600-08","in 10mM DMSO","p38 MAPK","MAPK","VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.",{"v":404.3,"d":"404.30"},"745833-23-2",{"v":81,"d":"81.00"},200.35,"<1","N/A","http://selleckchem.com/products/VX-702.html","C19H12F4N4O2","free base","N/A","NC(=O)N(C1=NC(=C(C=C1)C(N)=O)C2=C(F)C=C(F)C=C2)C3=C(F)C=CC=C3F",3.682,3,2,4]
["S6400","Glucosamine","h5","L2600-08","in 10mM DMSO","HIF","Angiogenesis","Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.",179.17,"3416-24-8",{"v":23,"d":"23.00"},128.37,{"v":36,"d":"36.00"},200.93,"http://www.selleck.cn/products/glucosamine.html","C6H13NO5","Free Base","2-amino-2-deoxy-D-glucose","NC(C=O)C(O)C(O)C(O)CO",-3.081,1,5,5]
["S6413","fexaramine","a6","L2600-08","in 10mM DMSO","FXR","Metabolism","Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.",496.64,"574013-66-4",{"v":99,"d":"99.00"},199.34,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/fexaramine.html","C32H36N2O3","Free Base","N/A","COC(=O)/C=C/C1=CC=CC(=C1)N(CC2=CC=C(C=C2)C3=CC=C(C=C3)N(C)C)C(=O)C4CCCCC4",{"v":6.87,"d":"6.870"},3,0,9]
["S6453","Bicyclol","b6","L2600-08","in 10mM DMSO","HBV","Microbiology","Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.",390.34,"118159-48-1",{"v":78,"d":"78.00"},199.83,"<1","N/A","http://www.selleck.cn/products/bicyclol.html","C19H18O9","Free Base","SY-801","COC(=O)C1=CC(=C2OCOC2=C1C3=C4OCOC4=C(OC)C=C3CO)OC",2.102,8,1,6]
["S6471","Lucanthone","c6","L2600-08","in 10mM DMSO","Autophagy","Autophagy","Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.",340.48,"479-50-5",{"v":33,"d":"33.00"},96.92,"<1","N/A","http://www.selleck.cn/products/lucanthone.html","C20H24N2OS","Free Base","N/A","CCN(CC)CCNC1=CC=C(C)C2=C1C(=O)C3=C(S2)C=CC=C3",4.653,1,1,6]
["S6503","LX2343","d6","L2600-08","in 10mM DMSO","BACE","Neuronal Signaling","LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.",474.91,"333745-53-2",{"v":95,"d":"95.00"},200.04,"<1","N/A","http://www.selleck.cn/products/lx2343.html","C22H19ClN2O6S","free base","N/A","COC1=CC=C(Cl)C=C1N(CC(=O)NC2=CC=C3OCOC3=C2)[S](=O)(=O)C4=CC=CC=C4",3.576,6,1,7]
["S6507","KN-92 phosphate","e6","L2600-08","in 10mM DMSO","CaMK","Neuronal Signaling","KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII).",554.98,"1135280-28-2",{"v":100,"d":"100.00"},180.19,"<1","N/A","http://www.selleck.cn/products/kn-92-phosphate.html","C24H28ClN2O7PS","phosphate","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2CN(C)C\\C=C\\C3=CC=C(Cl)C=C3.O[P](O)(O)=O",4.622,3,1,9]
["S6516","GNE-477","f6","L2600-08","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR.",504.63,"1032754-81-6",{"v":25,"d":"25.00"},49.54,"<1","N/A","http://www.selleck.cn/products/gne-477.html","C21H28N8O3S2","free base","N/A","CC1=C(CN2CCN(CC2)[S](C)(=O)=O)SC3=C(N=C(N=C13)C4=CN=C(N)N=C4)N5CCOCC5",0.991,7,1,5]
["S6533","Briciclib","g6","L2600-08","in 10mM DMSO","eIF","ER stress & UPR","Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).",474.42,"865783-99-9",{"v":95,"d":"95.00"},200.24,"<1","N/A","http://www.selleck.cn/products/briciclib.html","C19H23O10PS","free base","ON-014185","COC1=CC(=C(/C=C/[S](=O)(=O)CC2=CC=C(OC)C(=C2)O[P](O)(O)=O)C(=C1)OC)OC",2.319,7,0,10]
["S6541","MTX-211","h6","L2600-08","in 10mM DMSO","EGFR,PI3K","Protein Tyrosine Kinase","MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase.",478.33,"1952236-05-3",{"v":24,"d":"24.00"},50.17,"<1","N/A","http://www.selleck.cn/products/mtx-211.html","C20H14Cl2FN5O2S","free base","N/A","C[S](=O)(=O)NC1=CC(=CN=C1Cl)C2=CC3=C(NC4=CC=C(F)C(=C4)Cl)N=CN=C3C=C2",4.499,5,2,5]
["S6605","AR7","a7","L2600-08","in 10mM DMSO","Retinoid Receptor","Metabolism","AR7 is a retinoic acid receptor α (RARα) antagonist.",257.71,"80306-38-3",{"v":4,"d":"4.00"},15.52,"<1","N/A","http://www.selleck.cn/products/ar7.html","C15H12ClNO","free base","N/A","CC1=CC=C(C=C1)C2=NC3=C(OC2)C=C(Cl)C=C3",4.227,2,0,1]
["S6609","JZL195","b7","L2600-08","in 10mM DMSO","FAAH,Lipase","Metabolism","JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.",433.46,"1210004-12-8",{"v":43,"d":"43.00"},{"v":99.2,"d":"99.20"},"<1","N/A","http://www.selleck.cn/products/jzl195.html","C24H23N3O5","free base","N/A","[O-][N+](=O)C1=CC=C(OC(=O)N2CCN(CC2)CC3=CC=CC(=C3)OC4=CC=CC=C4)C=C1",4.794,3,0,7]
["S7007","Binimetinib (MEK162)","c7","L2600-08","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.",441.23,"606143-89-9",{"v":88,"d":"88.00"},199.44,"<1","N/A","http://selleckchem.com/products/mek162.html","C17H15BrF2N4O3","free base","ARRY-162,ARRY-438162","C[N]1C=NC2=C1C=C(C(=O)NOCCO)C(=C2F)NC3=C(F)C=C(Br)C=C3",2.775,3,3,6]
["S7009","LCL161","d7","L2600-08","in 10mM DMSO","IAP,Mitochondrial Metabolism","Apoptosis","LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).",500.63,"1005342-46-0",{"v":100,"d":"100.00"},199.75,"<1","N/A","http://selleckchem.com/products/lcl161.html","C26H33FN4O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(F)C=C4",3.785,4,2,8]
["S7016","VS-5584 (SB2343)","e7","L2600-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.",354.41,"1246560-33-7",{"v":71,"d":"71.00"},200.33,"<1","N/A","http://selleckchem.com/products/vs-5584-sb2343.html","C17H22N8O","free base","N/A","CC(C)[N]1C(=NC2=C1N=C(N=C2C3=CN=C(N)N=C3)N4CCOCC4)C",1.272,6,1,3]
["S7018","CZC24832","f7","L2600-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.",{"v":364.4,"d":"364.40"},"1159824-67-5",{"v":5,"d":"5.00"},13.72,"<1","N/A","http://selleckchem.com/products/czc24832.html","C15H17FN6O2S","free base","N/A","CC(C)(C)N[S](=O)(=O)C1=CN=CC(=C1)C2=C[N]3N=C(N)N=C3C(=C2)F",0.815,5,2,4]
["S7028","Duvelisib (IPI-145)","g7","L2600-08","in 10mM DMSO","PI3K","Angiogenesis","Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.",416.86,"1201438-56-3",{"v":83,"d":"83.00"},199.11,"<1","N/A","http://selleckchem.com/products/ipi-145-ink1197.html","C22H17ClN6O","free base","INK1197","CC(NC1=NC=NC2=C1N=C[NH]2)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)Cl",3.648,4,2,4]
["S7030","RG-7112","h7","L2600-08","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7033","GSK2656157","a8","L2600-08","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.",416.45,"1337532-29-2",{"v":32,"d":"32.00"},76.84,"<1","N/A","http://selleckchem.com/products/gsk2656157.html","C23H21FN6O","free base","N/A","C[N]1C=C(C2=C(F)C3=C(C=C2)N(CC3)C(=O)CC4=CC=CC(=N4)C)C5=C(N)N=CN=C15",2.926,4,1,3]
["S7039","PD168393","b8","L2600-08","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.",369.22,"194423-15-9",{"v":73,"d":"73.00"},197.71,"<1","N/A","http://selleckchem.com/products/pd168393.html","C17H13BrN4O","free base","N/A","BrC1=CC(=CC=C1)NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23",4.043,3,2,4]
["S7046","Brefeldin A","c8","L2600-08","in 10mM DMSO","Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy","Transmembrane Transporters","Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.",280.36,"20350-15-6",{"v":4,"d":"4.00"},14.27,"<1","N/A","http://selleckchem.com/products/brefeldin-a.html","C16H24O4","free base","BFA, Cyanein, Decumbin","CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1",2.152,2,2,0]
["S7049","Oprozomib (ONX 0912)","d8","L2600-08","in 10mM DMSO","Proteasome","Proteases","Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.",532.61,"935888-69-0",{"v":100,"d":"100.00"},187.75,"<1","N/A","http://selleckchem.com/products/oprozomib-onx-0912.html","C25H32N4O7S","free base","PR-047","COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3",-0.202,8,3,14]
["S7050","AZ20","e8","L2600-08","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM in a cell-free assay, 8-fold selectivity over mTOR.",412.51,"1233339-22-4",{"v":83,"d":"83.00"},201.21,"<1","N/A","http://selleckchem.com/products/az20.html","C21H24N4O3S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=O)=O)C4=CC=CC5=C4C=C[NH]5",3.038,5,1,4]
["S7051","CGI1746","f8","L2600-08","in 10mM DMSO","BTK","Angiogenesis","CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM.",579.69,"910232-84-7",{"v":100,"d":"100.00"},172.51,"<1","N/A","http://selleckchem.com/products/cgi1746.html","C34H37N5O4","free base","N/A","CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N3CCOCC3)C1=O)C4=CC=CC(=C4C)NC(=O)C5=CC=C(C=C5)C(C)(C)C",3.513,5,2,7]
["S7059","Tezacaftor (VX-661)","g8","L2600-08","in 10mM DMSO","CFTR","Transmembrane Transporters","Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.",{"v":520.5,"d":"520.50"},"1152311-62-0",{"v":100,"d":"100.00"},192.12,"<1","N/A","http://selleckchem.com/products/vx-661.html","C26H27F3N2O6","free base","N/A","CC(C)(CO)C1=CC2=CC(=C(F)C=C2[N]1CC(O)CO)NC(=O)C3(CC3)C4=CC=C5OC(F)(F)OC5=C4",5.215,3,4,8]
["S7063","LY2090314","h8","L2600-08","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.",512.53,"603288-22-8",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/ly2090314.html","C28H25FN6O3","free base","N/A","FC1=CC2=C3[N](CCN(C2)C(=O)N4CCCCC4)C=C(C3=C1)C5=C(C(=O)NC5=O)C6=CN=C7C=CC=C[N]67",2.707,4,1,2]
["S7065","MK-8745","a9","L2600-08","in 10mM DMSO","Aurora Kinase","Cell Cycle","MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.",431.91,"885325-71-3",{"v":86,"d":"86.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-8745.html","C20H19ClFN5OS","free base","N/A","FC1=C(C=CC=C1Cl)C(=O)N2CCN(CC2)CC3=CC=CC(=N3)NC4=NC=CS4",3.805,3,1,5]
["S7067","Tepotinib (EMD 1214063)","b9","L2600-08","in 10mM DMSO","Autophagy,c-Met","Protein Tyrosine Kinase","Tepotinib (EMD 1214063, MSC2156119) is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib (EMD 1214063) induces autophagy. Phase 1.",492.57,"1100598-32-0",{"v":5,"d":"5.00"},10.15,"<1","N/A","http://selleckchem.com/products/emd-1214063.html","C29H28N6O2","free base","MSC2156119","CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4N=C(C=CC4=O)C5=CC(=CC=C5)C#N",3.629,5,0,7]
["S7087","GSK2334470","c9","L2600-08","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM in a cell-free assay, with no activity at other close related AGC-kinases.",462.59,"1227911-45-6",{"v":90,"d":"90.00"},194.56,"<1","N/A","http://selleckchem.com/products/gsk2334470.html","C25H34N8O","free base","N/A","CNC1=NC(=CC(=N1)N2CC(CCC2C)C(=O)NC3CCCCC3)C4=CC5=C(C=C4)C(=N[NH]5)N",4.516,4,4,5]
["S7091","Zotarolimus (ABT-578)","d9","L2600-08","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Zotarolimus (ABT-578,A 179578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.",966.21,"221877-54-9",{"v":100,"d":"100.00"},{"v":103.5,"d":"103.50"},"<1","N/A","http://selleckchem.com/products/zotarolimus-abt-578.html","C52H79N5O12","free base","A 179578","COC1CC(CCC1[N]2C=NN=N2)CC(C)C3CC(=O)C(C)/C=C(C)/C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC4CCC(C)C(O)(O4)C(=O)C(=O)N5CCCCC5C(=O)O3)OC",5.793,13,1,7]
["S7103","Taselisib (GDC 0032)","e9","L2600-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Taselisib (GDC 0032, RG7604) is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.",460.53,"1282512-48-4",{"v":70,"d":"70.00"},{"v":152,"d":"152.00"},"<1","N/A","http://selleckchem.com/products/gdc-0032.html","C24H28N8O2","free base","RG7604","CC(C)[N]1N=C(C)N=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)C5=C[N](N=C5)C(C)(C)C(N)=O",{"v":2.47,"d":"2.470"},6,1,5]
["S7104","AZD1208","f9","L2600-08","in 10mM DMSO","Apoptosis related,Autophagy,Pim","JAK/STAT","AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.",379.48,"1204144-28-4",{"v":75,"d":"75.00"},197.64,"<1","N/A","http://selleckchem.com/products/azd-1208.html","C21H21N3O2S","free base","N/A","NC1CCCN(C1)C2=C(C=CC=C2C3=CC=CC=C3)\\C=C\\4SC(=O)NC4=O",3.283,2,2,3]
["S7106","AZD3463","g9","L2600-08","in 10mM DMSO","ALK,Apoptosis related,Autophagy,IGF-1R","Protein Tyrosine Kinase","AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy.",448.95,"1356962-20-3",{"v":24,"d":"24.00"},53.46,"<1","N/A","http://selleckchem.com/products/azd3463.html","C24H25ClN6O","free base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)C3=C[NH]C4=C3C=CC=C4)C=CC(=C1)N5CCC(N)CC5",4.316,3,3,5]
["S7110","(+)-JQ1","h9","L2600-08","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1","N/A","http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7113","Zebularine (NSC 309132)","a10","L2600-08","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay.",{"v":228.2,"d":"228.20"},"3690-10-6",{"v":46,"d":"46.00"},201.58,{"v":46,"d":"46.00"},201.58,"http://selleckchem.com/products/zebularine.html","C9H12N2O5","free base","4-Deoxyuridine","OCC1OC(C(O)C1O)N2C=CC=NC2=O",-1.747,3,3,2]
["S7121","Tovorafenib (MLN2480)","b10","L2600-08","in 10mM DMSO","Raf","MAPK","Tovorafenib (MLN2480, BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101) is an oral, selective pan-Raf kinase inhibitor in chinical trials.",506.29,"1096708-71-2",{"v":100,"d":"100.00"},197.52,"<1","N/A","http://selleckchem.com/products/mln2480.html","C17H12Cl2F3N7O2S","free base","BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101","CC(NC(=O)C1=C(Cl)C(=NC=N1)N)C2=NC=C(S2)C(=O)NC3=NC=C(Cl)C(=C3)C(F)(F)F",2.932,6,3,6]
["S7129","PYR-41","c10","L2600-08","in 10mM DMSO","Apoptosis related,E1 Activating","Ubiquitin","PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. PYR-41 induce apoptosis.",{"v":371.3,"d":"371.30"},"418805-02-4",{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/pyr-41.html","C17H13N3O7","free base","N/A","CCOC(=O)C1=CC=C(C=C1)N2NC(=O)C(=C/C3=CC=C(O3)[N+]([O-])=O)/C2=O",{"v":1.87,"d":"1.870"},5,1,6]
["S7130","PR-619","d10","L2600-08","in 10mM DMSO","Autophagy,DUB","Ubiquitin","PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.",223.28,"2645-32-1",{"v":45,"d":"45.00"},201.54,"<1","N/A","http://selleckchem.com/products/pr-619.html","C7H5N5S2","free base","N/A","NC1=C(SC#N)C=C(SC#N)C(=N1)N",1.212,1,2,2]
["S7132","P5091 (P005091)","e10","L2600-08","in 10mM DMSO","DUB","Ubiquitin","P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.",348.22,"882257-11-6",{"v":28,"d":"28.00"},80.41,"<1","N/A","http://selleckchem.com/products/p5091-p005091.html","C12H7Cl2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=CC(=C2Cl)Cl)[N+]([O-])=O",4.989,1,0,4]
["S7133","P22077","f10","L2600-08","in 10mM DMSO","DUB","Ubiquitin","P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.",315.32,"1247819-59-5",{"v":63,"d":"63.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/p22077.html","C12H7F2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=C(F)C=C2F)[N+]([O-])=O",4.071,1,0,4]
["S7134","IU1","g10","L2600-08","in 10mM DMSO","Autophagy,DUB","Proteases","IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy.",300.37,"314245-33-5",{"v":60,"d":"60.00"},199.75,"<1","N/A","http://selleckchem.com/products/iu1.html","C18H21FN2O","free base","N/A","CC1=CC(=C(C)[N]1C2=CC=C(F)C=C2)C(=O)CN3CCCC3",3.409,1,0,4]
["S7135","LDN-57444","h10","L2600-08","in 10mM DMSO","DUB","Proteases","LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.",397.64,"668467-91-2",{"v":11,"d":"11.00"},27.66,"<1","N/A","http://selleckchem.com/products/ldn-57444.html","C17H11Cl3N2O3","free base","N/A","CC(=O)O\\N=C/1C(=O)N(CC2=CC(=CC=C2Cl)Cl)C3=CC=C(Cl)C=C13",4.343,4,0,4]
["S7139","CFTRinh-172","a11","L2600-08","in 10mM DMSO","CFTR","Transmembrane Transporters","CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.",{"v":409.4,"d":"409.40"},"307510-92-5",{"v":82,"d":"82.00"},200.29,"<1","N/A","http://selleckchem.com/products/cftrinh-172.html","C18H10F3NO3S2","free base","CFTR inhibitor 172","OC(=O)C1=CC=C(C=C1)\\C=C/2SC(=S)N(C2=O)C3=CC=CC(=C3)C(F)(F)F",5.195,2,0,4]
["S7140","TCID","b11","L2600-08","in 10mM DMSO","DUB","Ubiquitin","TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.",283.92,"30675-13-9",{"v":23,"d":"23.00"},81.01,"<1","N/A","http://selleckchem.com/products/tcid.html","C9H2Cl4O2","free base","N/A","ClC1=C(Cl)C(=C2C(=O)CC(=O)C2=C1Cl)Cl",3.982,2,0,0]
["S7145","AZD1080","c11","L2600-08","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.",334.37,"612487-72-6",{"v":52,"d":"52.00"},155.52,"<1","N/A","http://selleckchem.com/products/azd1080.html","C19H18N4O2","free base","N/A","OC1=C(C2=CC=C(CN3CCOCC3)C=N2)C4=CC(=CC=C4[NH]1)C#N",2.442,2,2,3]
["S7146","DMH1","d11","L2600-08","in 10mM DMSO","Autophagy,TGF-beta/Smad","TGF-beta/Smad","DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy.",380.44,"1206711-16-1",{"v":22,"d":"22.00"},57.83,"<1","N/A","http://selleckchem.com/products/dmh1.html","C24H20N4O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CC=NC5=C4C=CC=C5",4.036,4,0,4]
["S7149","NSC 319726","e11","L2600-08","in 10mM DMSO","p53","Apoptosis","NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.",234.32,"71555-25-4",{"v":19,"d":"19.00"},81.09,"<1","N/A","http://selleckchem.com/products/nsc319726.html","C11H14N4S","free base","N/A","CC(=N\\NC(=S)N1CCC1)/C2=NC=CC=C2",1.906,2,1,4]
["S7152","C646","f11","L2600-08","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy.",445.42,"328968-36-1",{"v":13,"d":"13.00"},29.19,"<1","N/A","http://selleckchem.com/products/c646.html","C24H19N3O6","free base","N/A","CC1=C(C)C=C(C(=C1)C2=CC=C(O2)\\C=C/3C(=NN(C3=O)C4=CC=C(C=C4)C(O)=O)C)[N+]([O-])=O",4.736,4,0,5]
["S7153","10058-F4","g11","L2600-08","in 10mM DMSO","Apoptosis related,Autophagy,Myc","Cell Cycle","10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 promotes a caspase-3-dependent apoptosis and modulates autophagy.",249.35,"403811-55-2",{"v":49,"d":"49.00"},196.51,"<1","N/A","http://selleckchem.com/products/10058-f4.html","C12H11NOS2","free base","N/A","CCC1=CC=C(C=C1)\\C=C/2SC(=S)NC2=O",3.783,1,1,2]
["S7162","Mdivi-1","h11","L2600-08","in 10mM DMSO","Apoptosis related,Dynamin,Mitophagy","Cytoskeletal Signaling","Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.",353.22,"338967-87-6",{"v":70,"d":"70.00"},198.18,"<1","N/A","http://selleckchem.com/products/mdivi-1.html","C15H10Cl2N2O2S","free base","Mitochondrial division inhibitor 1","COC1=C(Cl)C=C(Cl)C(=C1)N2C(=NC3=C(C=CC=C3)C2=O)S",4.943,3,0,2]
["S7165","UNC1999","a2","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.",569.74,"1431612-23-5",{"v":50,"d":"50.00"},87.76,"<1","N/A","http://selleckchem.com/products/unc1999.html","C33H43N7O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(CC5)C(C)C)C(=O)NC(=C1)C",4.629,4,2,9]
["S7170","Avutometinib","b2","L2600-09","in 10mM DMSO","MEK,Raf","MAPK","Avutometinib(RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.",471.46,"946128-88-7",{"v":94,"d":"94.00"},199.38,"<1","N/A","http://selleckchem.com/products/ro5126766-ch5126766.html","C21H18FN5O5S","free base","RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304","CN[S](=O)(=O)NC1=NC=CC(=C1F)CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O",2.473,8,2,7]
["S7177","PF-543 hydrochloride","c2","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,SPHK","Immunology & Inflammation","PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.",502.07,"1706522-79-3",{"v":93,"d":"93.00"},185.23,"<1","N/A","http://selleckchem.com/products/pf-543.html","C27H32ClNO4S","hydrochloride","N/A","Cl.CC1=CC(=CC(=C1)C[S;v6](=O)(=O)C2=CC=CC=C2)OCC3=CC=C(CN4CCCC4CO)C=C3",5.016,3,1,9]
["S7188","CID755673","d2","L2600-09","in 10mM DMSO","CaMK,PKD","Apoptosis","CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.",217.22,"521937-07-5",{"v":43,"d":"43.00"},196.13,"<1","N/A","http://selleckchem.com/products/cid755673.html","C12H11NO3","free base","N/A","OC1=CC2=C(OC3=C2CCCNC3=O)C=C1",1.922,2,2,0]
["S7198","BIO","e2","L2600-09","in 10mM DMSO","Apoptosis related,CDK,GSK-3,JAK","PI3K/Akt/mTOR","BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.",356.17,"667463-62-9",{"v":71,"d":"71.00"},199.34,"<1","N/A","http://selleckchem.com/products/bio.html","C16H10BrN3O2","free base","GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052","O\\N=C/1\\C(NC2=CC=CC=C12)=C3\\C(=O)NC4=C3C=CC(=C4)Br",2.692,2,2,0]
["S7199","DBeQ","f2","L2600-09","in 10mM DMSO","p97","Ubiquitin","DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.",340.42,"177355-84-9",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://selleckchem.com/products/dbeq.html","C22H20N4","free base","JRF 12","C(NC1=NC2=CC=CC=C2C(=N1)NCC3=CC=CC=C3)C4=CC=CC=C4",5.232,2,2,6]
["S7205","Idasanutlin (RG-7388)","g2","L2600-09","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7213","Thiamet G","h2","L2600-09","in 10mM DMSO","OGA","Autophagy","Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.",{"v":248.3,"d":"248.30"},"1009816-48-1",{"v":50,"d":"50.00"},201.37,{"v":50,"d":"50.00"},201.37,"http://selleckchem.com/products/thiamet-g.html","C9H16N2O4S","free base","N/A","CCNC1=NC2C(O)C(O)C(CO)OC2S1",-0.613,2,4,3]
["S7214","Skepinone-L","a3","L2600-09","in 10mM DMSO","p38 MAPK","MAPK","Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.",425.42,"1221485-83-1",{"v":85,"d":"85.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/skepinone-l.html","C24H21F2NO4","free base","CBS3830","OCC(O)COC1=CC=C2CCC3=CC(=CC=C3C(=O)C2=C1)NC4=CC=C(F)C=C4F",4.729,2,3,6]
["S7215","Losmapimod (GW856553X)","b3","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,p38 MAPK","MAPK","Losmapimod (GW856553X, GW856553, GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. P38 MAPKs are involved in cell differentiation, apoptosis and autophagy. Phase 3.",383.46,"585543-15-3",{"v":76,"d":"76.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/losmapimod-gw856553x.html","C22H26FN3O2","free base","GW856553, GSK-AHAB","CC1=C(F)C=C(C=C1C2=CC=C(C=N2)C(=O)NCC(C)(C)C)C(=O)NC3CC3",3.689,3,2,6]
["S7253","AZD2858","c3","L2600-09","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.",453.52,"486424-20-8",{"v":7,"d":"7.00"},15.43,"<1","N/A","http://selleckchem.com/products/azd2858.html","C21H23N7O3S","free base","N/A","CN1CCN(CC1)[S](=O)(=O)C2=CC=C(C=C2)C3=CN=C(N)C(=N3)C(=O)NC4=CN=CC=C4",0.405,6,2,5]
["S7261","Beta-Lapachone","d3","L2600-09","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.",242.27,"4707-32-8",{"v":33,"d":"33.00"},136.21,"<1","N/A","http://selleckchem.com/products/beta-lapachone.html","C15H14O3","free base","β-Lapachone, ARQ-501","CC1(C)CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O",2.509,3,0,0]
["S7285","NMS-873","e3","L2600-09","in 10mM DMSO","p97","Ubiquitin","NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).",520.67,"1418013-75-8",{"v":100,"d":"100.00"},192.06,"<1","N/A","http://selleckchem.com/products/nms-873.html","C27H28N4O3S2","free base","N/A","CC1=CC(=CC=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3=NN=C(SC4CCCC4)[N]3C5=CN=CC=C5",5.602,6,0,8]
["S7289","PFK15","f3","L2600-09","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.",260.29,"4382-63-2",{"v":19,"d":"19.00"},{"v":73,"d":"73.00"},"<1","N/A","http://selleckchem.com/products/pfk15.html","C17H12N2O","free base","PFK-015","O=C(\\C=C\\C1=CC=C2C=CC=CC2=N1)C3=CC=NC=C3",3.166,3,0,3]
["S7291","TAK-632","g3","L2600-09","in 10mM DMSO","Raf","MAPK","TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.",554.52,"1228591-30-7",{"v":100,"d":"100.00"},180.34,"<1","N/A","http://selleckchem.com/products/tak-632.html","C27H18F4N4O3S","free base","N/A","FC1=C(NC(=O)CC2=CC=CC(=C2)C(F)(F)F)C=C(OC3=C(C#N)C4=C(C=C3)N=C(NC(=O)C5CC5)S4)C=C1",{"v":5.74,"d":"5.740"},4,2,8]
["S7292","RG2833 (RGFP109)","h3","L2600-09","in 10mM DMSO","HDAC","Epigenetics","RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3 in cell-free assays, respectively.",339.43,"1215493-56-3",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://selleckchem.com/products/rg2833-rgfp109.html","C20H25N3O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N",2.895,2,3,8]
["S7293","ZCL278","a4","L2600-09","in 10mM DMSO","Rho","Cell Cycle","ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.",584.89,"587841-73-4",{"v":100,"d":"100.00"},170.97,"<1","N/A","http://selleckchem.com/products/zcl278.html","C21H19BrClN5O4S2","free base","N/A","CC1=CC(=NC(=N1)N[S](=O)(=O)C2=CC=C(NC(=S)NC(=O)COC3=C(Cl)C=C(Br)C=C3)C=C2)C",4.809,6,3,9]
["S7305","MS436","b4","L2600-09","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","MS436 is a selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively.",383.42,"1395084-25-9",{"v":55,"d":"55.00"},143.45,"<1","N/A","http://selleckchem.com/products/ms436.html","C18H17N5O3S","free base","N/A","CC1=C(O)C=C(N)C(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.573,5,3,5]
["S7307","GSK2606414","c4","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.",451.44,"1337531-36-8",{"v":90,"d":"90.00"},199.36,"<1","N/A","http://selleckchem.com/products/gsk2606414.html","C24H20F3N5O","free base","N/A","C[N]1C=C(C2=CC=C3N(CCC3=C2)C(=O)CC4=CC=CC(=C4)C(F)(F)F)C5=C1N=CN=C5N",4.103,3,1,4]
["S7309","BAY 87-2243","d4","L2600-09","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7310","SF1670","e4","L2600-09","in 10mM DMSO","PTEN","PI3K/Akt/mTOR","SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.",307.34,"345630-40-2",{"v":29,"d":"29.00"},94.36,"<1","N/A","http://selleckchem.com/products/sf1670.html","C19H17NO3","free base","N/A","CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=C(C=CC=C3)C(=O)C2=O",3.475,3,1,2]
["S7317","WZ4003","f4","L2600-09","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.",496.99,"1214265-58-3",{"v":7,"d":"7.00"},14.08,"<1","N/A","http://selleckchem.com/products/wz4003.html","C25H29ClN6O3","free base","N/A","CCC(=O)NC1=CC=CC(=C1)OC2=NC(=NC=C2Cl)NC3=C(OC)C=C(C=C3)N4CCN(C)CC4",4.776,5,2,8]
["S7318","HTH-01-015","g4","L2600-09","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.",468.55,"1613724-42-7",{"v":58,"d":"58.00"},123.79,"<1","N/A","http://selleckchem.com/products/hth-01-015.html","C26H28N8O","free base","N/A","CN1C(=O)C2=C(C=C3C=CC=CC3=C2)N(C)C4=NC(=NC(=C14)C)NC5=C[N](N=C5)C6CCNCC6",2.993,4,2,3]
["S7319","EHop-016","h4","L2600-09","in 10mM DMSO","Rho","Cell Cycle","EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.",430.55,"1380432-32-5",{"v":86,"d":"86.00"},199.74,"<1","N/A","http://selleckchem.com/products/ehop-016.html","C25H30N6O","free base","N/A","CC[N]1C2=C(C=CC=C2)C3=C1C=CC(=C3)NC4=NC(=NC=C4)NCCCN5CCOCC5",4.407,3,2,8]
["S7329","IOWH032","a5","L2600-09","in 10mM DMSO","CFTR","Transmembrane Transporters","IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.",545.18,"1191252-49-9",{"v":100,"d":"100.00"},183.43,"<1","N/A","http://selleckchem.com/products/iowh032.html","C22H15Br2N3O4","free base","N/A","OC1=C(Br)C=C(C=C1Br)C2=NOC(=N2)C(=O)NCC3=CC=C(OC4=CC=CC=C4)C=C3",5.233,5,2,6]
["S7334","ERK5-IN-1","b5","L2600-09","in 10mM DMSO","ERK","MAPK","ERK5-IN-1 (XMD17-109) is a potent, and selective ERK5 inhibitor with IC50 of 162 nM.",638.81,"1435488-37-1",{"v":100,"d":"100.00"},156.54,"<1","N/A","http://selleckchem.com/products/erk5-in-1.html","C36H46N8O3","free base","XMD17-109","CCOC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C5CCCC5)C3=N2)C=CC(=C1)C(=O)N6CCC(CC6)N7CCN(C)CC7",4.794,5,1,7]
["S7335","IPI-3063","c5","L2600-09","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.",455.51,"1425043-73-7",{"v":91,"d":"91.00"},199.78,"<1","N/A","http://selleckchem.com/products/ipi-3063.html","C25H25N7O2","free base","N/A","CC(C)N1C(=O)C2=C(C=CC=C2C=C1C(C)NC3=C(C#N)C(=NC=N3)N)C4=CN(C)C(=O)C=C4",1.621,4,2,5]
["S7343","URMC-099","d5","L2600-09","in 10mM DMSO","Autophagy,Bcr-Abl,LRRK2,Mixed Lineage Kinase","MAPK","URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. URMC-099 also inhibits ABL1 with IC50 of 6.8 nM. URMC-099 induces autophagy.",421.54,"1229582-33-5",{"v":84,"d":"84.00"},199.27,"<1","N/A","http://selleckchem.com/products/urmc-099.html","C27H27N5","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C([NH]C=C4C5=CC=C6[NH]C=CC6=C5)N=C3",4.533,1,2,4]
["S7356","HS-173","e5","L2600-09","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM.",422.46,"1276110-06-5",{"v":84,"d":"84.00"},198.84,"<1","N/A","http://selleckchem.com/products/hs-173.html","C21H18N4O4S","free base","N/A","CCOC(=O)C1=CN=C2C=CC(=C[N]12)C3=CN=CC(=C3)N[S](=O)(=O)C4=CC=CC=C4",2.058,6,1,7]
["S7367","GNE-0877","f5","L2600-09","in 10mM DMSO","LRRK2","Autophagy","GNE-0877 (DNL201) is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM.",339.32,"1374828-69-9",{"v":67,"d":"67.00"},197.45,"<1","N/A","http://selleckchem.com/products/gne-0877.html","C14H16F3N7","free base","DNL201","CNC1=NC(=NC=C1C(F)(F)F)NC2=C[N](N=C2C)C(C)(C)C#N",2.871,3,2,5]
["S7368","GNE-9605","g5","L2600-09","in 10mM DMSO","LRRK2","Autophagy","GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.",449.83,"1536200-31-3",{"v":89,"d":"89.00"},197.85,"<1","N/A","http://selleckchem.com/products/gne-9605.html","C17H20ClF4N7O","free base","N/A","CNC1=NC(=NC=C1C(F)(F)F)NC2=C(Cl)[N](N=C2)C3CCN(CC3F)C4COC4",2.715,4,2,6]
["S7369","4EGI-1","h5","L2600-09","in 10mM DMSO","Apoptosis related,eIF,mTOR","Cell Cycle","4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.",451.28,"315706-13-9",{"v":90,"d":"90.00"},199.43,"<1","N/A","http://selleckchem.com/products/4egi-1.html","C18H12Cl2N4O4S","free base","N/A","OC(=O)C(/CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(=CS2)C3=CC=C(Cl)C(=C3)Cl",5.397,3,1,7]
["S7370","4E1RCat","a6","L2600-09","in 10mM DMSO","eIF","Cell Cycle","4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.",478.45,"328998-25-0",{"v":96,"d":"96.00"},200.65,"<1","N/A","http://selleckchem.com/products/4e1rcat.html","C28H18N2O6","free base","N/A","OC(=O)C1=CC=C(C=C1)N2C(=O)\\C(=C\\C3=CC=C(O3)C4=CC=C(C=C4)[N+]([O-])=O)C=C2C5=CC=CC=C5",5.414,3,0,6]
["S7372","PTC-209","b6","L2600-09","in 10mM DMSO","BMI-1","Cell Cycle","PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).",495.19,"315704-66-6",{"v":99,"d":"99.00"},199.92,"<1","N/A","http://selleckchem.com/products/ptc-209.html","C17H13Br2N5OS","Free Base","N/A","COC1=CC(=C(NC2=NC(=CS2)C3=C(C)N=C4N=CC=C[N]34)C(=C1)Br)Br",4.871,4,1,4]
["S7379","E-64","c6","L2600-09","in 10mM DMSO","Apoptosis related,Cathepsin B,Cysteine Protease,Parasite","Proteases","E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.",357.41,"66701-25-5",{"v":71,"d":"71.00"},198.65,{"v":11,"d":"11.00"},30.78,"http://selleckchem.com/products/e-64.html","C15H27N5O5","free base","N/A","CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCNC(N)=N",-0.864,4,4,12]
["S7381","Pepstatin A","d6","L2600-09","in 10mM DMSO","Autophagy,Cysteine Protease,HIV Protease","Proteases","Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.",685.89,"26305-03-3",{"v":57,"d":"57.00"},{"v":83.1,"d":"83.10"},"<1","N/A","http://selleckchem.com/products/pepstatin-a.html","C34H63N5O9","free base","Pepstatin","CC(C)CC(NC(=O)C(C)NC(=O)CC(O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)C(O)CC(O)=O",2.301,6,7,22]
["S7397","Sorafenib (BAY 43-9006)","e6","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1","N/A","http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7409","Anisomycin","f6","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,JNK","MAPK","Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.",{"v":265.3,"d":"265.30"},"22862-76-6",{"v":41,"d":"41.00"},154.54,"<1","N/A","http://selleckchem.com/products/anisomycin.html","C14H19NO4","free base","Flagecidin, Wuningmeisu C","COC1=CC=C(CC2NCC(O)C2OC(C)=O)C=C1",0.877,3,2,5]
["S7411","Ascomycin (FK520)","g6","L2600-09","in 10mM DMSO","Anti-infection","Microbiology","Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.",792.01,"104987-12-4",{"v":100,"d":"100.00"},126.26,"<1","N/A","http://selleckchem.com/products/ascomycin-fk520.html","C43H69NO12","free base","FR 900520, Immunomycin","CCC1/C=C(C)/CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)\\C(C)=C\\C4CCC(O)C(C4)OC",4.766,9,2,6]
["S7421","CGP 57380","h6","L2600-09","in 10mM DMSO","Apoptosis related,MNK,Wnt/beta-catenin","MAPK","CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.",244.23,"522629-08-9",{"v":48,"d":"48.00"},196.54,"<1","N/A","http://selleckchem.com/products/cgp57380.html","C11H9FN6","free base","N/A","NC1=C2C(=NC=N1)[NH]N=C2NC3=CC=C(F)C=C3",1.981,3,3,2]
["S7422","KN-62","a7","L2600-09","in 10mM DMSO","CaMK","Neuronal Signaling","KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.",721.84,"127191-97-3",{"v":100,"d":"100.00"},138.53,"<1","N/A","http://selleckchem.com/products/kn-62.html","C38H35N5O6S2","free base","N/A","CN(C(CC1=CC=C(O[S](=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1)C(=O)N4CCN(CC4)C5=CC=CC=C5)[S](=O)(=O)C6=CC=CC7=C6C=CN=C7",4.532,6,0,10]
["S7423","KN-93 Phosphate","b7","L2600-09","in 10mM DMSO","Autophagy,CaMK","Neuronal Signaling","KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 attenuates CaMKII-induced autophagy.",599.03,"1188890-41-6",{"v":100,"d":"100.00"},166.94,{"v":92,"d":"92.00"},153.58,"http://selleckchem.com/products/kn-93-phosphate.html","C26H29ClN2O4S.H3O4P","Phosphate","N/A","COC1=CC=C(C=C1)[S](=O)(=O)N(CCO)C2=CC=CC=C2CN(C)C\\C=C\\C3=CC=C(Cl)C=C3.O[P](O)(O)=O",4.288,3,1,11]
["S7430","SB-3CT","c7","L2600-09","in 10mM DMSO","MMP","Proteases","SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.",{"v":306.4,"d":"306.40"},"292605-14-2",{"v":61,"d":"61.00"},199.09,"<1","N/A","http://selleckchem.com/products/sb-3ct.html","C15H14O3S2","free base","N/A","O=[S](=O)(CC1CS1)C2=CC=C(OC3=CC=CC=C3)C=C2",3.377,3,0,5]
["S7435","AR-A014418","d7","L2600-09","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.",308.31,"487021-52-3",{"v":61,"d":"61.00"},197.85,"<1","N/A","http://selleckchem.com/products/A014418.html","C12H12N4O4S","free base","GSK-3β Inhibitor VIII","COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1",1.529,3,2,5]
["S7436","NH125","e7","L2600-09","in 10mM DMSO","CaMK","Neuronal Signaling","NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.",524.56,"278603-08-0",{"v":100,"d":"100.00"},190.64,"<1","N/A","http://selleckchem.com/products/nh125.html","C27H45IN2","iodide","N/A","[I-].CCCCCCCCCCCCCCCC[N+]1=C(C)[N](CC2=CC=CC=C2)C=C1",6.032,0,0,17]
["S7447","ZLN005","f7","L2600-09","in 10mM DMSO","PGC-1α","Metabolism","ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.",250.34,"49671-76-3",{"v":37,"d":"37.00"},{"v":147.8,"d":"147.80"},"<1","N/A","http://selleckchem.com/products/ZLN005.html","C17H18N2","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3[NH]2",{"v":4.67,"d":"4.670"},1,1,2]
["S7482","EHT 1864 2HCl","g7","L2600-09","in 10mM DMSO","Rho","Cell Cycle","EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.",581.47,"754240-09-0",{"v":100,"d":"100.00"},171.98,{"v":100,"d":"100.00"},171.98,"http://selleckchem.com/products/eht-1864.html","C25H29Cl2F3N2O4S","dihydrochloride","N/A","Cl.Cl.FC(F)(F)C1=CC2=C(C=C1)C(=CC=N2)SCCCCCOC3=COC(=CC3=O)CN4CCOCC4",4.663,5,0,11]
["S7483","DMOG","h7","L2600-09","in 10mM DMSO","Autophagy,HIF,Hydroxylase","Metabolism","DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.",175.14,"89464-63-1",{"v":35,"d":"35.00"},199.84,{"v":35,"d":"35.00"},199.84,"http://selleckchem.com/products/dmog.html","C6H9NO5","free base","Dimethyloxalylglycine","COC(=O)CNC(=O)C(=O)OC",-0.918,5,1,5]
["S7489","YH239-EE","a8","L2600-09","in 10mM DMSO","MDM2/MDMX","Apoptosis","YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.",504.41,"1364488-67-4",{"v":100,"d":"100.00"},198.25,"<1","N/A","http://selleckchem.com/products/yh239-ee.html","C25H27Cl2N3O4","free base","N/A","CCOC(=O)C1=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(=O)NC(C)(C)C)C3=C([NH]1)C=C(Cl)C=C3",4.912,4,2,9]
["S7492","Uprosertib (GSK2141795)","b8","L2600-09","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Uprosertib (GSK2141795, GSK795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.",429.25,"1047634-65-0",{"v":85,"d":"85.00"},198.02,"<1","N/A","http://selleckchem.com/products/gsk2141795.html","C18H16Cl2F2N4O2","free base","GSK795","C[N]1N=CC(=C1C2=C(Cl)OC(=C2)C(=O)NC(CN)CC3=CC(=C(F)C=C3)F)Cl",3.531,3,2,6]
["S7508","JNK Inhibitor IX","c8","L2600-09","in 10mM DMSO","JNK","MAPK","JNK inhibitor IX (TCS JNK 5a) is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.",332.42,"312917-14-9",{"v":20,"d":"20.00"},60.16,"<1","N/A","http://selleckchem.com/products/jnk-inhibitor-ix.html","C20H16N2OS","free base","TCS JNK 5a","O=C(NC1=C(C#N)C2=C(CCCC2)S1)C3=CC=CC4=C3C=CC=C4",4.571,1,1,2]
["S7515","VGX-1027","d8","L2600-09","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.",205.21,"6501-72-0",{"v":41,"d":"41.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/vgx-1027.html","C11H11NO3","free base","GIT 27","OC(=O)CC1CC(=NO1)C2=CC=CC=C2",1.368,3,0,3]
["S7521","Afuresertib (GSK2110183)","e8","L2600-09","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.",427.32,"1047644-62-1",{"v":85,"d":"85.00"},198.91,"<1","N/A","http://selleckchem.com/products/afuresertib-gsk2110183.html","C18H17Cl2FN4OS","free base","N/A","C[N]1N=CC(=C1C2=C(Cl)SC(=C2)C(=O)NC(CN)CC3=CC=CC(=C3)F)Cl",3.884,2,2,6]
["S7524","FR 180204","f8","L2600-09","in 10mM DMSO","ERK","MAPK","FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK1, MKK4, IKKα, PKCα, Src, Syc, and PDGFα) at less than 30 μM.",327.34,"865362-74-9",{"v":65,"d":"65.00"},198.57,"<1","N/A","http://selleckchem.com/products/fr180204.html","C18H13N7","free base","N/A","NC1=N[NH]C2=C1C=C(N=N2)C3=C4C=CC=C[N]4N=C3C5=CC=CC=C5",2.969,4,2,2]
["S7525","XMD8-92","g8","L2600-09","in 10mM DMSO","Epigenetic Reader Domain,ERK","MAPK","XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with Kd of 80 nM and 170 nM for ERK5 and BRD4(1), respectively.",474.55,"1234480-50-2",{"v":73,"d":"73.00"},153.83,"<1","N/A","http://selleckchem.com/products/xmd8-92.html","C26H30N6O3","free base","N/A","CCOC1=CC(=CC=C1NC2=NC3=C(C=N2)N(C)C(=O)C4=C(C=CC=C4)N3C)N5CCC(O)CC5",3.505,4,2,5]
["S7528","GNE-7915","h8","L2600-09","in 10mM DMSO","LRRK2","Autophagy","GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor,  with IC50 and Ki of 9 nM and 1 nM, respectively.",{"v":443.4,"d":"443.40"},"1351761-44-8",{"v":22,"d":"22.00"},49.62,"<1","N/A","http://selleckchem.com/products/gne-7915.html","C19H21F4N5O3","free base","N/A","CCNC1=NC(=NC=C1C(F)(F)F)NC2=CC(=C(C=C2OC)C(=O)N3CCOCC3)F",3.052,5,2,7]
["S7545","G-749","a9","L2600-09","in 10mM DMSO","FLT3","Angiogenesis","G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.",521.41,"1457983-28-6",{"v":24,"d":"24.00"},46.03,"<1","N/A","http://selleckchem.com/products/g-749.html","C25H25BrN6O2","free base","N/A","CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(OC5=CC=CC=C5)C=C4",3.919,4,3,6]
["S7551","Piperlongumine","b9","L2600-09","in 10mM DMSO","CRM1,ROS","Immunology & Inflammation","Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.",317.34,"20069-09-4",{"v":16,"d":"16.00"},50.42,"<1","N/A","http://selleckchem.com/products/piperlongumine.html","C17H19NO5","free base","PPLGM, Piplartine","COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O",2.135,5,0,5]
["S7553","GDC-0623","c9","L2600-09","in 10mM DMSO","MEK","MAPK","GDC-0623 (G-868) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.",456.21,"1168091-68-6",{"v":91,"d":"91.00"},199.47,"<1","N/A","http://selleckchem.com/products/gdc-0623.html","C16H14FIN4O3","free base","G-868","OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)[N]3C=NC=C3C=C1",2.284,3,3,6]
["S7563","AT13148","d9","L2600-09","in 10mM DMSO","Akt,PKA,ROCK,S6 Kinase","PI3K/Akt/mTOR","AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.",313.78,"1056901-62-2",{"v":62,"d":"62.00"},197.59,"<1","N/A","http://selleckchem.com/products/at13148.html","C17H16ClN3O","free base","N/A","NCC(O)(C1=CC=C(Cl)C=C1)C2=CC=C(C=C2)C3=C[NH]N=C3",2.491,1,2,4]
["S7566","IM-12","e9","L2600-09","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.",377.41,"1129669-05-1",{"v":75,"d":"75.00"},198.72,"<1","N/A","http://selleckchem.com/products/im-12.html","C22H20FN3O2","free base","N/A","CN1C(=O)C(=C(C1=O)C2=C(C)[NH]C3=C2C=CC=C3)NCCC4=CC=C(F)C=C4",3.074,2,2,5]
["S7569","LMK-235","f9","L2600-09","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.",294.35,"1418033-25-6",{"v":58,"d":"58.00"},197.04,"<1","N/A","http://selleckchem.com/products/lmk-235.html","C15H22N2O4","free base","N/A","CC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)C",2.204,3,2,8]
["S7584","LRRK2-IN-1","g9","L2600-09","in 10mM DMSO","LRRK2","Autophagy","LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.",570.69,"1234480-84-2",{"v":100,"d":"100.00"},175.23,"<1","N/A","http://selleckchem.com/products/lrrk2-in-1.html","C31H38N8O3","free base","N/A","COC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C)C3=N2)C=CC(=C1)C(=O)N5CCC(CC5)N6CCN(C)CC6",3.043,5,1,5]
["S7588","Reversine","h9","L2600-09","in 10mM DMSO","Adenosine Receptor,Aurora Kinase","GPCR & G Protein","Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation.",393.23,"656820-32-5",{"v":5,"d":"5.00"},12.72,"<1","N/A","http://selleckchem.com/products/reversine.html","C21H27N7O","free base","N/A","C1CCC(CC1)NC2=C3N=C[NH]C3=NC(=N2)NC4=CC=C(C=C4)N5CCOCC5",3.893,4,3,5]
["S7591","BRD4770","a10","L2600-09","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.",413.47,"1374601-40-7",{"v":27,"d":"27.00"},{"v":65.3,"d":"65.30"},"<1","N/A","http://selleckchem.com/products/brd4770.html","C25H23N3O3","free base","N/A","COC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4",5.094,4,1,8]
["S7606","RBC8","b10","L2600-09","in 10mM DMSO","Ras","GPCR & G Protein","RBC8 is a selective inhibitor of the GTPases RalA and RalB by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA.",424.45,"361185-42-4",{"v":84,"d":"84.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/rbc8.html","C25H20N4O3","free base","N/A","COC1=CC(=C(OC)C=C1)C2C(=C(N)OC3=C2C(=N[NH]3)C4=CC=C5C=CC=CC5=C4)C#N",4.253,4,2,4]
["S7607","BQU57","c10","L2600-09","in 10mM DMSO","Ras","Cell Cycle","BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.",{"v":334.1,"d":"334.10"},"1637739-82-2",{"v":66,"d":"66.00"},197.55,"<1","N/A","http://selleckchem.com/products/bqu57.html","C16H13F3N4O","free base","N/A","C[N]1N=C(C)C2=C1OC(=C(C#N)C2C3=CC=C(C=C3)C(F)(F)F)N",2.861,2,1,2]
["S7612","PX-478 2HCl","d10","L2600-09","in 10mM DMSO","Apoptosis related,HIF","Angiogenesis","PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.",394.12,"685898-44-6",{"v":78,"d":"78.00"},197.91,{"v":78,"d":"78.00"},197.91,"http://selleckchem.com/products/px-478-2hcl.html","C13H20Cl4N2O3","dihydrochloride","N/A","Cl.Cl.NC(CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O",-0.251,1,1,8]
["S7623","PI-3065","e10","L2600-09","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.",506.64,"955977-50-1",{"v":50,"d":"50.00"},98.69,"<1","N/A","http://selleckchem.com/products/pi-3065.html","C27H31FN6OS","free base","N/A","FC1=C(C2=NC3=C(SC(=C3)CN4CCN(CC4)CC5CC5)C(=N2)N6CCOCC6)C7=C([NH]C=C7)C=C1",4.778,3,1,6]
["S7636","SU9516","f10","L2600-09","in 10mM DMSO","CDK","Cell Cycle","SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.",241.25,"377090-84-1",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/su9516.html","C13H11N3O2","free base","N/A","COC1=CC=C2NC(=O)C(=C\\C3=CN=C[NH]3)/C2=C1",0.893,3,2,2]
["S7637","DTP3","g10","L2600-09","in 10mM DMSO","DNA/RNA Synthesis,JNK,NF-κB","MAPK","DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.",{"v":525.6,"d":"525.60"},"1809784-29-9",{"v":100,"d":"100.00"},190.26,{"v":100,"d":"100.00"},190.26,"http://selleckchem.com/products/dtp3.html","C26H35N7O5","free base","N/A","CC(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC2=CC=CC=C2)C(N)=O",{"v":0,"d":"0.000"},4,7,15]
["S7642","D 4476","h10","L2600-09","in 10mM DMSO","Casein Kinase","Metabolism","D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.",398.41,"301836-43-1",{"v":79,"d":"79.00"},198.29,"<1","N/A","http://selleckchem.com/products/d-4476.html","C23H18N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=CC=N3)C4=CC5=C(OCCO5)C=C4",3.464,5,2,4]
["S7645","Pilaralisib (XL147)","a11","L2600-09","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.",541.02,"934526-89-3",{"v":100,"d":"100.00"},184.84,"<1","N/A","http://selleckchem.com/products/pilaralisib-xl147.html","C25H25ClN6O4S","free base","N/A","COC1=CC(=C(Cl)C=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=CC(=C4)NC(=O)C(C)(C)N",4.012,6,4,8]
["S7646","Voxtalisib (XL765)","b11","L2600-09","in 10mM DMSO","mTOR,PI3K","Angiogenesis","Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",270.29,"934493-76-2",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/voxtalisib-xl765-sar245409.html","C13H14N6O","free base","SAR245409","CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C3=CC=N[NH]3",0.838,4,2,2]
["S7648","OTS964","c11","L2600-09","in 10mM DMSO","Apoptosis related,Autophagy,CDK,TOPK","MAPK","OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.",428.97,"1338545-07-5",{"v":85,"d":"85.00"},198.15,"<1","N/A","http://selleckchem.com/products/ots964.html","C23H24N2O2S.HCl","dihydrochloride","N/A","Cl.Cl.CC(CN(C)C)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",5.497,1,2,4]
["S7649","MI-773 (SAR405838)","d11","L2600-09","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7651","SB225002","e11","L2600-09","in 10mM DMSO","CXCR","GPCR & G Protein","SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.",352.14,"182498-32-4",{"v":70,"d":"70.00"},198.78,"<1","N/A","http://selleckchem.com/products/sb225002.html","C13H10BrN3O4","free base","N/A","OC1=CC(=CC=C1NC(=O)NC2=C(Br)C=CC=C2)[N+]([O-])=O",2.923,1,3,3]
["S7652","OTS514 hydrochloride","f11","L2600-09","in 10mM DMSO","Apoptosis related,TOPK","MAPK","OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.",400.92,"2319647-76-0",{"v":80,"d":"80.00"},199.54,{"v":80,"d":"80.00"},199.54,"http://selleckchem.com/products/ots514.html","C21H20N2O2S.HCl","hydrochloride","N/A","Cl.CC(CN)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",4.147,1,3,3]
["S7655","Telaglenastat (CB-839)","g11","L2600-09","in 10mM DMSO","Autophagy,Glutaminase","Proteases","Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.",571.57,"1439399-58-2",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/cb-839.html","C26H24F3N7O3S","free base","N/A","FC(F)(F)OC1=CC(=CC=C1)CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2",5.597,8,2,13]
["S7660","Obeticholic Acid","h11","L2600-09","in 10mM DMSO","Autophagy,FXR","Metabolism","Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.",420.63,"459789-99-2",{"v":84,"d":"84.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/obeticholic-acid.html","C26H44O4","free base","INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid","CCC1C(O)C2C3CCC(C(C)CCC(O)=O)C3(C)CCC2C4(C)CCC(O)CC14",{"v":4.79,"d":"4.790"},1,2,5]
["S7664","GSK2578215A","a2","L2600-10","in 10mM DMSO","LRRK2","Autophagy","GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.",399.42,"1285515-21-0",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/gsk2578215a.html","C24H18FN3O2","free base","N/A","FC1=NC=CC(=C1)C2=CC(=C(OCC3=CC=CC=C3)C=C2)C(=O)NC4=CC=CN=C4",3.985,4,1,6]
["S7675","PF-4989216","b2","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.",{"v":380.4,"d":"380.40"},"1276553-09-3",{"v":76,"d":"76.00"},199.79,"<1","N/A","http://selleckchem.com/products/pf-4989216.html","C18H13FN6OS","free base","N/A","FC1=C(C=CC(=C1)C#N)C2=C(SC(=C2C#N)N3CCOCC3)C4=NC=N[NH]4",2.924,3,1,3]
["S7680","SP2509","c2","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,Histone Demethylase,LSD1","Epigenetics","SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of  13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.",{"v":437.9,"d":"437.90"},"1423715-09-6",{"v":38,"d":"38.00"},86.78,"<1","N/A","http://selleckchem.com/products/sp2509.html","C19H20ClN3O5S","free base","HCI-2509","CC(=N\\NC(=O)C1=CC=CC(=C1)[S](=O)(=O)N2CCOCC2)/C3=CC(=CC=C3O)Cl",1.891,5,2,5]
["S7683","PIK-III","d2","L2600-10","in 10mM DMSO","Autophagy,LC3,PI3K","Autophagy","PIK-III (VPS34-IN2), which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.",319.36,"1383716-40-2",{"v":63,"d":"63.00"},197.27,"<1","N/A","http://selleckchem.com/products/pik-iii.html","C17H17N7","free base","VPS34-IN2","NC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",{"v":2.2,"d":"2.200"},5,2,5]
["S7684","Salirasib","e2","L2600-10","in 10mM DMSO","Autophagy,PPMTase,Ras","Cell Cycle","Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.",358.54,"162520-00-5","The physical form of the compound is fat, and can be dissolved in any proportion in DMSO","N/A","N/A","N/A","http://selleckchem.com/products/salirasib.html","C22H30O2S","free base","Farnesylthiosalicylic acid, FTS","CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC1=CC=CC=C1C(O)=O",{"v":7.12,"d":"7.120"},1,0,10]
["S7686","ML141","f2","L2600-10","in 10mM DMSO","Apoptosis related,p38 MAPK,Rho","Cell Cycle","ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.",407.49,"71203-35-5",{"v":81,"d":"81.00"},198.78,"<1","N/A","http://selleckchem.com/products/ml141.html","C22H21N3O3S","free base","CID-2950007","COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)[S](N)(=O)=O)C4=CC=CC=C4",{"v":3.87,"d":"3.870"},4,1,5]
["S7694","AZD8186","g2","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.",457.47,"1627494-13-6",{"v":91,"d":"91.00"},198.92,"<1","N/A","http://selleckchem.com/products/azd8186.html","C24H25F2N3O4","free base","N/A","CC(NC1=CC(=CC(=C1)F)F)C2=CC(=CC3=C2OC(=CC3=O)N4CCOCC4)C(=O)N(C)C",3.418,4,1,5]
["S7709","VX-11e","h2","L2600-10","in 10mM DMSO","ERK","MAPK","VX-11e (VTX-11e, Vertex-11e) is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.",500.35,"896720-20-0",{"v":100,"d":"100.00"},199.86,"<1","N/A","http://selleckchem.com/products/vx-11e.html","C24H20Cl2FN5O2","free base","VTX-11e, Vertex-11e","CC1=CN=C(NC2=C(Cl)C=C(F)C=C2)N=C1C3=C[NH]C(=C3)C(=O)NC(CO)C4=CC=CC(=C4)Cl",5.755,3,4,7]
["S7720","SBE 13 HCl","a3","L2600-10","in 10mM DMSO","PLK","Cell Cycle","SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.",{"v":479.4,"d":"479.40"},"1052532-15-6",{"v":95,"d":"95.00"},198.16,"<1","N/A","http://selleckchem.com/products/sbe-13-hcl.html","C24H28Cl2N2O4","hydrochloride","N/A","Cl.COC1=CC=C(CCNCC2=CC=C(OCC3=CN=C(Cl)C=C3)C(=C2)OC)C=C1OC",4.895,5,1,11]
["S7722","Bikinin","b3","L2600-10","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.",273.08,"188011-69-0",{"v":54,"d":"54.00"},197.74,"<1","N/A","http://selleckchem.com/products/bikinin.html","C9H9BrN2O3","free base","N/A","OC(=O)CCC(=O)NC1=NC=C(Br)C=C1",0.932,3,1,4]
["S7723","PRIMA-1","c3","L2600-10","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7724","Eprenetapopt (APR-246)","d3","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,p53","Apoptosis","Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.",199.25,"5291-32-7",{"v":40,"d":"40.00"},200.75,"N/A","N/A","http://selleckchem.com/products/apr-246-prima-1met.html","C10H17NO3","free base","PRIMA-1MET","COCC1(CO)N2CCC(CC2)C1=O",-0.364,2,1,3]
["S7741","SB239063","e3","L2600-10","in 10mM DMSO","p38 MAPK","MAPK","SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.",{"v":368.4,"d":"368.40"},"193551-21-2",{"v":60,"d":"60.00"},162.87,"<1","N/A","http://selleckchem.com/products/sb239063.html","C20H21FN4O2","free base","N/A","COC1=NC=CC(=N1)C2=C(N=C[N]2C3CCC(O)CC3)C4=CC=C(F)C=C4",3.661,4,1,4]
["S7743","CCT196969","f3","L2600-10","in 10mM DMSO","Raf,Src","MAPK","CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.",513.52,"1163719-56-9",{"v":100,"d":"100.00"},194.73,"<1","N/A","http://selleckchem.com/products/cct196969.html","C27H24FN7O3","free base","N/A","CC(C)(C)C1=N[N](C(=C1)NC(=O)NC2=CC=C(OC3=C4N=CC(=O)NC4=NC=C3)C=C2F)C5=CC=CC=C5",4.782,6,3,6]
["S7747","Ro-3306","g3","L2600-10","in 10mM DMSO","Apoptosis related,Bcl-2,CDK","Cell Cycle","RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.",351.45,"872573-93-8",{"v":13,"d":"13.00"},36.99,"<1","N/A","http://selleckchem.com/products/ro-3306.html","C18H13N3OS2","free base","N/A","O=C1N=C(NCC2=CC=CS2)S\\C1=C/C3=CC=C4N=CC=CC4=C3",3.712,3,1,4]
["S7751","VER155008","h3","L2600-10","in 10mM DMSO","Autophagy,HSP (HSP90)","Cytoskeletal Signaling","VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.",{"v":556.4,"d":"556.40"},"1134156-31-2",{"v":100,"d":"100.00"},179.73,"<1","N/A","http://selleckchem.com/products/ver155008.html","C25H23Cl2N7O4","free base","C07","NC1=C2N=C(NCC3=CC=C(Cl)C(=C3)Cl)[N](C4OC(COCC5=CC=C(C=C5)C#N)C(O)C4O)C2=NC=N1",3.253,5,4,8]
["S7752","Pluripotin (SC1)","a4","L2600-10","in 10mM DMSO","ERK,S6 Kinase","MAPK","Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Pluripotin also inhibits RSK1, RSK2, RSK3 and RSK4 with IC50 of 0.5 µM, 2.5 µM, 3.3 µM and 10.0 µM, respectively.",550.53,"839707-37-8",{"v":100,"d":"100.00"},181.64,"<1","N/A","http://selleckchem.com/products/pluripotin-sc1.html","C27H25F3N8O2","free base","N/A","C[N]1N=C(C)C=C1NC2=NC=C3CN(C(=O)N(C)C3=N2)C4=CC(=CC=C4C)NC(=O)C5=CC=CC(=C5)C(F)(F)F",4.789,5,2,6]
["S7774","SU6656","b4","L2600-10","in 10mM DMSO","Src","Angiogenesis","SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.",371.45,"330161-87-0",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://selleckchem.com/products/su6656.html","C19H21N3O3S","free base","N/A","CN(C)[S](=O)(=O)C1=CC=C2NC(=O)C(=C\\C3=CC4=C(CCCC4)[NH]3)/C2=C1",2.616,3,2,3]
["S7776","Akti-1/2","c4","L2600-10","in 10mM DMSO","Akt,Apoptosis related","PI3K/Akt/mTOR","Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.",551.64,"612847-09-3",{"v":22,"d":"22.00"},39.88,"<1","N/A","http://selleckchem.com/products/akti-1-2.html","C34H29N7O","free base","Akt Inhibitor VIII","O=C1NC2=C(C=CC=C2)N1C3CCN(CC3)CC4=CC=C(C=C4)C5=C(N=C6C=C7[NH]C=NC7=CC6=N5)C8=CC=CC=C8",5.466,4,2,5]
["S7781","Sunitinib (SU11248)","d4","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1","N/A","http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7786","Erlotinib (OSI-774)","e4","L2600-10","in 10mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.",393.44,"183321-74-6",{"v":78,"d":"78.00"},198.25,"<1","N/A","http://selleckchem.com/products/erlotinib.html","C22H23N3O4","free base","CP358774, NSC 718781, Tarceva","COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.309,6,1,10]
["S7793","Purvalanol A","f4","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,CDK","Cell Cycle","Purvalanol A is a potent, and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated apoptosis and autophagy.",388.89,"212844-53-6",{"v":60,"d":"60.00"},154.29,"<1","N/A","http://selleckchem.com/products/purvalanol-a.html","C19H25ClN6O","free base","N/A","CC(C)C(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NC3=CC=CC(=C3)Cl",4.462,3,3,7]
["S7798","GNE-317","g4","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GNE-317 is a potent, brain-penetrant PI3K inhibitor.",414.48,"1394076-92-6",{"v":47,"d":"47.00"},{"v":113.4,"d":"113.40"},"<1","N/A","http://selleckchem.com/products/gne-317.html","C19H22N6O3S","free base","N/A","COC1(COC1)C2=C(C)C3=C(S2)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",{"v":1.5,"d":"1.500"},7,1,4]
["S7799","Pexmetinib (ARRY-614)","h4","L2600-10","in 10mM DMSO","p38 MAPK,Tie-2","MAPK","Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor  with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.",556.63,"945614-12-0",{"v":100,"d":"100.00"},179.65,"<1","N/A","http://selleckchem.com/products/pexmetinib-arry-614.html","C31H33FN6O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NCC3=C(OC4=CC5=C(C=C4)[N](CCO)N=C5)C=CC(=C3)F)C(C)(C)C",6.271,4,3,9]
["S7808","AT7519 HCl","a5","L2600-10","in 10mM DMSO","CDK","Cell Cycle","AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.",418.71,"902135-91-5",{"v":52,"d":"52.00"},124.19,{"v":43,"d":"43.00"},{"v":102.7,"d":"102.70"},"http://selleckchem.com/products/at7519-hcl.html","C16H18Cl3N5O2","Hydrochloride","N/A","Cl.ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",{"v":1.98,"d":"1.980"},3,4,4]
["S7810","Afatinib (BIBW2992) Dimaleate","b5","L2600-10","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.",717.18,"850140-73-7",{"v":100,"d":"100.00"},139.44,"<1","N/A","http://selleckchem.com/products/afatinib-bibw2992-dimaleate.html","C24H25ClFN5O3.2C4H4O4","Dimaleate","N/A","CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",{"v":0.96,"d":"0.960"},9,2,12]
["S7811","MHY1485","c5","L2600-10","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.",387.39,"326914-06-1",{"v":4,"d":"4.00"},10.33,"<1","N/A","http://selleckchem.com/products/mhy1485.html","C17H21N7O4","free base","N/A","[O-][N+](=O)C1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C=C1",2.653,5,1,5]
["S7813","AMG319","d5","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.",{"v":385.4,"d":"385.40"},"1608125-21-8",{"v":77,"d":"77.00"},199.79,"<1","N/A","http://selleckchem.com/products/amg319.html","C21H16FN7","free base","N/A","CC(NC1=C2N=C[NH]C2=NC=N1)C3=C(N=C4C=C(F)C=CC4=C3)C5=CC=CC=N5",3.691,5,2,4]
["S7828","Licochalcone A","e5","L2600-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.",{"v":338.4,"d":"338.40"},"58749-22-7",{"v":67,"d":"67.00"},197.99,"<1","N/A","http://selleckchem.com/products/licochalcone-a.html","C21H22O4","free base","N/A","COC1=C(/C=C/C(=O)C2=CC=C(O)C=C2)C=C(C(=C1)O)C(C)(C)C=C",4.667,2,2,6]
["S7843","BI-847325","f5","L2600-10","in 10mM DMSO","Aurora Kinase,MEK","MAPK","BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.",464.56,"1207293-36-4",{"v":19,"d":"19.00"},{"v":40.9,"d":"40.90"},"<1","N/A","http://selleckchem.com/products/bi-847325.html","C29H28N4O2","free base","N/A","CCNC(=O)C#CC1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4",4.041,2,3,8]
["S7854","Ulixertinib (BVD-523)","g5","L2600-10","in 10mM DMSO","ERK","MAPK","Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.",433.33,"869886-67-9",{"v":86,"d":"86.00"},198.46,"<1","N/A","http://selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html","C21H22Cl2N4O2","free base","VRT752271","CC(C)NC1=NC=C(Cl)C(=C1)C2=C[NH]C(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl",4.266,2,4,7]
["S7857","8-Bromo-cAMP","h5","L2600-10","in 10mM DMSO","PKA","GPCR & G Protein","8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.",430.08,"76939-46-3",{"v":5,"d":"5.00"},11.63,{"v":80,"d":"80.00"},186.01,"http://selleckchem.com/products/8-bromo-camp.html","C10H10BrN5NaO6P","sodium salt","8-Br-Camp,8-Bromo-cAMP Sodium","NC1=NC=NC2=C1N=C(Br)[N]2C3OC4CO[P](=O)(O[Na])OC4C3O",-0.479,7,2,2]
["S7858","Dibutyryl-cAMP (Bucladesine)","a6","L2600-10","in 10mM DMSO","PDE,PKA","GPCR & G Protein","Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.",491.37,"16980-89-5",{"v":98,"d":"98.00"},199.44,{"v":98,"d":"98.00"},199.44,"http://selleckchem.com/products/dibutyryl-camp-bucladesine.html","C18H23N5NaO8P","sodium salt","dbcAMP","CCCC(=O)NC1=NC=NC2=C1N=C[N]2C3OC4CO[P](=O)(O[Na])OC4C3OC(=O)CCC",1.028,10,1,9]
["S7875","NVP-CGM097","b6","L2600-10","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7885","SBI-0206965","c6","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,ULK","Autophagy","SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.",489.32,"1884220-36-3",{"v":97,"d":"97.00"},198.23,"<1","N/A","http://selleckchem.com/products/sbi-0206965.html","C21H21BrN4O5","free base","N/A","CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(OC)C(=C3)OC)OC",4.128,7,2,8]
["S7886","Onatasertib (CC 223)","d6","L2600-10","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.",397.47,"1228013-30-6",{"v":79,"d":"79.00"},198.76,"<1","N/A","http://selleckchem.com/products/cc-223.html","C21H27N5O3","free base","ATG-008","COC1CCC(CC1)N2C(=O)CNC3=NC=C(N=C23)C4=CN=C(C=C4)C(C)(C)O",{"v":1.66,"d":"1.660"},5,1,4]
["S7888","Spautin-1","e6","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,DUB","Autophagy","Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.",271.26,"1262888-28-7",{"v":54,"d":"54.00"},199.07,"<1","N/A","http://selleckchem.com/products/spautin-1.html","C15H11F2N3","free base","N/A","FC1=CC=C(CNC2=NC=NC3=CC=C(F)C=C23)C=C1",{"v":3.73,"d":"3.730"},2,1,3]
["S7891","CC-115","f6","L2600-10","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.",336.35,"1228013-15-7",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cc-115.html","C16H16N8O","free base","N/A","CCN1C(=O)CNC2=NC=C(N=C12)C3=C(C)N=C(C=C3)C4=N[NH]C=N4",0.664,6,2,3]
["S7898","GSK621","g6","L2600-10","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","GSK621 is a specific and potent AMPK activator.",489.91,"1346607-05-3",{"v":97,"d":"97.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/gsk621.html","C26H20ClN3O5","free base","N/A","COC1=CC(=CC=C1)N2C(=O)NC3=C([N](C(=C3)Cl)C4=CC=C(C=C4)C5=C(O)C(=CC=C5)OC)C2=O",5.217,4,2,5]
["S7906","PFI-4","h6","L2600-10","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.",380.44,"900305-37-5",{"v":17,"d":"17.00"},44.69,"<1","N/A","http://selleckchem.com/products/pfi-4.html","C21H24N4O3","free base","N/A","COC1=C(C=CC=C1)C(=O)NC2=C(C=C3N(C)C(=O)N(C)C3=C2)N4CCCC4",2.496,3,1,4]
["S7917","Kenpaullone","a7","L2600-10","in 10mM DMSO","CDK","Cell Cycle","Kenpaullone (9-Bromopaullone, NSC-664704) is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.",327.18,"142273-20-9",{"v":65,"d":"65.00"},198.67,"<1","N/A","http://selleckchem.com/products/kenpaullone.html","C16H11BrN2O","free base","9-Bromopaullone, NSC-664704","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3C=CC=C4)C=C1",3.671,1,2,0]
["S7921","DEL-22379","b7","L2600-10","in 10mM DMSO","ERK","MAPK","DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.",444.53,"181223-80-3",{"v":89,"d":"89.00"},200.21,"<1","N/A","http://selleckchem.com/products/del-22379.html","C26H28N4O3","free base","N/A","COC1=CC2=C([NH]C=C2C=C3C(=O)NC4=CC=C(NC(=O)CCN5CCCCC5)C=C34)C=C1",{"v":3.3,"d":"3.300"},3,3,6]
["S7922","Tiplaxtinin (PAI-039)","c7","L2600-10","in 10mM DMSO","PAI-1","Metabolism","Tiplaxtinin(PAI-039) is an orally efficacious and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 μM.",439.38,"393105-53-8",{"v":72,"d":"72.00"},163.87,"<1","N/A","http://selleckchem.com/products/tiplaxtinin-pai-039.html","C24H16F3NO4","free base","N/A","OC(=O)C(=O)C1=C[N](CC2=CC=CC=C2)C3=CC=C(C=C13)C4=CC=C(OC(F)(F)F)C=C4",7.066,3,0,7]
["S7931","STF-31","d7","L2600-10","in 10mM DMSO","GLUT","Metabolism","STF-31 is a selective glucose transporter GLUT1 inhibitor.",423.53,"724741-75-7",{"v":85,"d":"85.00"},200.69,"<1","N/A","http://selleckchem.com/products/stf-31.html","C23H25N3O3S","free base","N/A","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3",3.359,4,2,7]
["S7937","Nemiralisib","e7","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).",440.54,"1254036-71-9",{"v":88,"d":"88.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk2269557.html","C26H28N6O","free base","GSK2269557","CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=CC(=CC4=C3C=N[NH]4)C5=CC=CC6=C5C=C[NH]6",3.943,3,2,5]
["S7948","MRT67307 HCl","f7","L2600-10","in 10mM DMSO","Autophagy,IκB/IKK,TBK1,ULK","NF-κB","MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.","464.6 (free-base)","1781882-89-0",{"v":92,"d":"92.00"},198.02,{"v":92,"d":"92.00"},198.02,"https://www.selleckchem.com/products/mrt67307-hcl.html","C26H36N6O2.xHCl","hydrochloride","N/A","O=C(NCCCNC1=NC(=NC=C1C2CC2)NC3=CC(=CC=C3)CN4CCOCC4)C5CCC5",4.257,4,3,11]
["S7949","MRT68921 HCl","g7","L2600-10","in 10mM DMSO","Autophagy,ULK","Autophagy","MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.","434.58 (free base)","2070014-87-6",{"v":10,"d":"10.00"},23.01,"<1","N/A","http://selleckchem.com/products/mrt68921.html","C25H34N6O.xHCl","hydrochloride","N/A","CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C4CC4)C(=N3)NCCCNC(=O)C5CCC5",4.644,3,3,9]
["S7953","ETC-1002","h7","L2600-10","in 10mM DMSO","AMPK,ATP-citrate lyase,LDL","PI3K/Akt/mTOR","ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).",344.49,"738606-46-7",{"v":68,"d":"68.00"},197.39,"<1","N/A","http://selleckchem.com/products/etc-1002.html","C19H36O5","free base","Bempedoic acid, ESP-55016","CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O",{"v":5.18,"d":"5.180"},2,1,14]
["S7964","PLX7904","a8","L2600-10","in 10mM DMSO","Raf","MAPK","PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.",512.53,"1393465-84-3",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/plx7904.html","C24H22F2N6O3S","free base","PB04","CCN(C)[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CN=C(N=C4)C5CC5",2.291,6,2,8]
["S7965","PLX8394","b8","L2600-10","in 10mM DMSO","Raf","MAPK","PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.",542.53,"1393466-87-9",{"v":100,"d":"100.00"},184.32,"<1","N/A","http://www.selleckchem.com/products/plx8394.html","C25H21F3N6O3S","Free Base","N/A","FC1CCN(C1)[S](=O)(=O)NC2=CC=C(F)C(=C2F)C(=O)C3=C[NH]C4=NC=C(C=C34)C5=CN=C(N=C5)C6CC6",2.252,6,2,7]
["S7966","AZD8835","c8","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).",469.54,"1620576-64-8",{"v":93,"d":"93.00"},198.07,"<1","N/A","http://selleckchem.com/products/azd8835.html","C22H31N9O3","free base","N/A","CC[N]1N=C(N=C1C2=CN=C(N)C(=N2)C3=NN=C(O3)C(C)(C)C)C4CCN(CC4)C(=O)CCO",0.942,8,2,7]
["S7976","SBC-115076","d8","L2600-10","in 10mM DMSO","PCSK9","Metabolism","SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.",527.61,"489415-96-5",{"v":33,"d":"33.00"},62.55,"<1","N/A","http://selleckchem.com/products/sbc-115076.html","C31H33N3O5","free base","N/A","CC1=C(OCC2=CC=CC=C2)C=CC(=C1)C(=O)C3=C(O)C(=O)N(CCCN4CCOCC4)C3C5=CC=NC=C5",3.177,5,1,10]
["S7980","VPS34-IN1","e8","L2600-10","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates autophagy.",425.91,"1383716-33-3",{"v":85,"d":"85.00"},199.57,"<1","N/A","http://selleckchem.com/products/vps34-in1.html","C21H24ClN7O","free base","Vps34-IN-1","CC(C)(O)CNC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC(=C4)Cl",3.672,5,2,8]
["S7998","Entrectinib (RXDX-101)","f8","L2600-10","in 10mM DMSO","ALK,Autophagy,ROS1,Trk receptor","Protein Tyrosine Kinase","Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.",560.64,"1108743-60-7",{"v":100,"d":"100.00"},178.37,"<1","N/A","http://selleckchem.com/products/entrectinib-rxdx-101.html","C31H34F2N6O2","free base","NMS-E628","CN1CCN(CC1)C2=CC=C(C(=O)NC3=N[NH]C4=C3C=C(CC5=CC(=CC(=C5)F)F)C=C4)C(=C2)NC6CCOCC6",4.952,3,3,7]
["S7999","SKF96365","g8","L2600-10","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8000","Tenovin-1","h8","L2600-10","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).",369.48,"380315-80-0",{"v":74,"d":"74.00"},200.28,"<1","N/A","http://selleckchem.com/products/tenovin-1.html","C20H23N3O2S","free base","N/A","CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",4.287,2,3,6]
["S8001","Ricolinostat (ACY-1215)","a9","L2600-10","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.",{"v":433.5,"d":"433.50"},"1316214-52-4",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/rocilinostat-acy-1215.html","C24H27N5O3","free base","Rocilinostat","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",3.917,4,2,11]
["S8002","GSK2636771","b9","L2600-10","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3Kβ with >900-fold selectivity over PI3Kα/PI3Kγ and >10-fold over PI3Kδ. Sensitive to PTEN null cell lines.",433.42,"1372540-25-4",{"v":28,"d":"28.00"},{"v":64.6,"d":"64.60"},"<1","N/A","http://selleckchem.com/products/gsk2636771.html","C22H22F3N3O3","free base","N/A","CC1=NC2=C(C=C(C=C2[N]1CC3=CC=CC(=C3C)C(F)(F)F)N4CCOCC4)C(O)=O",4.303,3,0,5]
["S8005","SMI-4a","c9","L2600-10","in 10mM DMSO","Pim","JAK/STAT","SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.",273.23,"438190-29-5",{"v":55,"d":"55.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/smi-4a.html","C11H6F3NO2S","free base","TCS PIM-1 4a","FC(F)(F)C1=CC(=CC=C1)\\C=C2/SC(=O)NC2=O",2.884,2,1,2]
["S8006","BIX 01294","d9","L2600-10","in 10mM DMSO","Autophagy,G9a/GLP,Histone Methyltransferase,NSD","Epigenetics","BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.",600.02,"1392399-03-9",{"v":98,"d":"98.00"},163.33,{"v":98,"d":"98.00"},163.33,"http://selleckchem.com/products/bix-01294.html","C28H38N6O2.3HCl","trihydrochloride","N/A","Cl.Cl.Cl.COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)CC4=CC=CC=C4)N5CCCN(C)CC5",5.246,4,1,7]
["S8015","Agerafenib (RXDX-105)","e9","L2600-10","in 10mM DMSO","c-Kit,c-RET,CSF-1R,PDGFR,Raf","MAPK","Agerafenib (RXDX-105, CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.",517.46,"1188910-76-0",{"v":9,"d":"9.00"},17.39,"<1","N/A","http://selleckchem.com/products/cep-32496.html","C24H22F3N5O5","free base","CEP-32496","COC1=CC2=NC=NC(=C2C=C1OC)OC3=CC(=CC=C3)NC(=O)NC4=NOC(=C4)C(C)(C)C(F)(F)F",5.288,8,2,8]
["S8019","Capivasertib (AZD5363)","f9","L2600-10","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.",428.92,"1143532-39-1",{"v":86,"d":"86.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://selleckchem.com/products/azd5363.html","C21H25ClN6O2","free base","N/A","NC1(CCN(CC1)C2=NC=NC3=C2C=C[NH]3)C(=O)NC(CCO)C4=CC=C(Cl)C=C4",1.317,3,4,6]
["S8031","NSC 23766","g9","L2600-10","in 10mM DMSO","Rho","Cell Cycle","NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related  targets, Cdc42 or RhoA.",530.96,"1177865-17-6",{"v":100,"d":"100.00"},188.34,{"v":100,"d":"100.00"},188.34,"http://selleckchem.com/products/nsc-23766.html","C24H35N7.3HCl","HCl","N/A","Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(N)C=C(C)N=C3C=C2)C",5.477,3,3,10]
["S8036","Butein","h9","L2600-10","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.",272.25,"487-52-5",{"v":55,"d":"55.00"},202.02,"<1","N/A","http://selleckchem.com/products/butein.html","C15H12O5","free base","N/A","OC1=CC(=C(C=C1)C(=O)\\C=C\\C2=CC(=C(O)C=C2)O)O",2.734,1,4,3]
["S8037","Necrostatin-1","a10","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,IDO/TDO,RIP kinase,TNF-alpha","Apoptosis","Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.",259.33,"4311-88-0",{"v":51,"d":"51.00"},196.66,"<1","N/A","http://selleckchem.com/products/necrostatin-1.html","C13H13N3OS","free base","Nec-1","CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S",2.472,1,2,2]
["S8040","GDC-0349","b10","L2600-10","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.",452.55,"1207360-89-1",{"v":91,"d":"91.00"},201.08,"<1","N/A","http://selleckchem.com/products/gdc-0349.html","C24H32N6O3","free base","RG-7603","CCNC(=O)NC1=CC=C(C=C1)C2=NC(=C3CCN(CC3=N2)C4COC4)N5CCOCC5C",1.982,5,2,5]
["S8041","Cobimetinib (GDC-0973)","c10","L2600-10","in 10mM DMSO","Apoptosis related,MEK","MAPK","Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.",531.31,"934660-93-2",{"v":100,"d":"100.00"},188.21,"<1","N/A","http://selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html","C21H21F3IN3O2","free base","RG7420,XL518","OC1(CN(C1)C(=O)C2=C(NC3=CC=C(I)C=C3F)C(=C(F)C=C2)F)C4CCCCN4",3.701,1,2,4]
["S8043","Scriptaid","d10","L2600-10","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Scriptaid (GCK 1026) is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.",326.35,"287383-59-9",{"v":65,"d":"65.00"},199.17,"<1","N/A","http://selleckchem.com/products/scriptaid.html","C18H18N2O4","free base","GCK 1026","ONC(=O)CCCCCN1C(=O)C2=C3C(=CC=C2)C=CC=C3C1=O",2.119,3,1,6]
["S8047","Dynasore","e10","L2600-10","in 10mM DMSO","Autophagy,Dynamin,HSV","Cytoskeletal Signaling","Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV).",322.31,"304448-55-3",{"v":64,"d":"64.00"},198.57,"<1","N/A","http://selleckchem.com/products/dynasore.html","C18H14N2O4","free base","N/A","OC1=C(O)C=C(C=C1)\\C=N\\NC(=O)C2=C(O)C=C3C=CC=CC3=C2",2.865,2,4,3]
["S8048","Venetoclax (ABT-199)","f10","L2600-10","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.",868.44,"1257044-40-8",{"v":100,"d":"100.00"},115.15,"<1","N/A","http://selleckchem.com/products/abt-199.html","C45H50ClN7O7S","free base","GDC-0199","CC1(C)CCC(=C(C1)C2=CC=C(Cl)C=C2)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)N[S](=O)(=O)C5=CC=C(NCC6CCOCC6)C(=C5)[N+]([O-])=O)OC7=CN=C8[NH]C=CC8=C7",{"v":7.94,"d":"7.940"},6,3,13]
["S8049","Tubastatin A","g10","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.",{"v":335.4,"d":"335.40"},"1252003-15-8",{"v":67,"d":"67.00"},199.76,"<1","N/A","https://www.selleckchem.com/products/tubastatin-a.html","C20H21N3O2","N/A","N/A","CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=C(C=C4)C(=O)NO",3.081,1,1,3]
["S8050","ETP-46464","h10","L2600-10","in 10mM DMSO","ATM/ATR,mTOR","PI3K/Akt/mTOR","ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.",470.52,"1345675-02-6",{"v":6,"d":"6.00"},12.75,"<1","N/A","http://selleckchem.com/products/etp-46464.html","C30H22N4O2","free base","N/A","CC(C)(C#N)C1=CC=C(C=C1)N2C(=O)OCC3=C2C4=C(C=CC(=C4)C5=CN=C6C=CC=CC6=C5)N=C3",5.813,4,0,3]
["S8065","Nutlin-3b","a11","L2600-10","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8071","UNC0638","b11","L2600-10","in 10mM DMSO","Antiviral,G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.",509.73,"1255580-76-7",{"v":100,"d":"100.00"},196.18,{"v":6,"d":"6.00"},11.77,"http://selleckchem.com/products/unc0638.html","C30H47N5O2","free base","N/A","COC1=CC2=C(NC3CCN(CC3)C(C)C)N=C(N=C2C=C1OCCCN4CCCC4)C5CCCCC5",5.284,4,1,10]
["S8072","NSC 405020","c11","L2600-10","in 10mM DMSO","MMP","Proteases","NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.",260.16,"7497-07-6",{"v":52,"d":"52.00"},199.88,"<1","N/A","http://selleckchem.com/products/nsc-405020.html","C12H15Cl2NO","free base","N/A","CCCC(C)NC(=O)C1=CC=C(Cl)C(=C1)Cl",4.073,1,1,4]
["S8078","Bardoxolone Methyl","d11","L2600-10","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8094","GlyH-101","e11","L2600-10","in 10mM DMSO","CFTR","Transmembrane Transporters","GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.",493.15,"328541-79-3",{"v":98,"d":"98.00"},198.72,"<1","N/A","http://selleckchem.com/products/glyh-101.html","C19H15Br2N3O3","free base","N/A","OC1=C(Br)C(=C(/C=N/NC(=O)CNC2=CC3=CC=CC=C3C=C2)C=C1Br)O",4.265,2,4,5]
["S8106","NSC59984","f11","L2600-10","in 10mM DMSO","p53","Apoptosis","NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.",265.27,"803647-40-7",{"v":53,"d":"53.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/nsc59984.html","C12H15N3O4","free base","N/A","CN1CCN(CC1)C(=O)\\C=C\\C2=CC=C(O2)[N+]([O-])=O",1.083,2,0,3]
["S8124","BMS-582949","g11","L2600-10","in 10mM DMSO","p38 MAPK","MAPK","BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.",406.48,"623152-17-0",{"v":81,"d":"81.00"},199.27,"<1","N/A","http://selleckchem.com/products/bms-582949.html","C22H26N6O2","free base","PS540446","CCCNC(=O)C1=C[N]2N=CN=C(NC3=CC(=CC=C3C)C(=O)NC4CC4)C2=C1C",3.269,4,3,7]
["S8125","Pamapimod","h11","L2600-10","in 10mM DMSO","p38 MAPK","MAPK","Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.",406.38,"449811-01-2",{"v":81,"d":"81.00"},199.32,"<1","N/A","http://selleckchem.com/products/pamapimod-r-1503-ro4402257.html","C19H20F2N4O4","free base","R-1503,Ro4402257","CN1C(=O)C(=CC2=CN=C(NC(CCO)CCO)N=C12)OC3=C(F)C=C(F)C=C3",1.298,4,3,8]
["S8132","Deguelin","a2","L2600-11","in 10mM DMSO","Akt,PI3K","PI3K/Akt/mTOR","Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an  PI3K/AKT Inhibitor.",394.42,"522-17-8",{"v":78,"d":"78.00"},197.76,"<1","N/A","http://selleckchem.com/products/deguelin.html","C23H22O6","free base","(-)-Deguelin, (-)-cis-Deguelin","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C5C=CC(C)(C)OC5=CC=C4C3=O",3.567,6,0,2]
["S8149","NSC348884","b2","L2600-11","in 10mM DMSO","Apoptosis related,p53","Apoptosis","NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.",636.79,"81624-55-7",{"v":100,"d":"100.00"},157.04,"<1","N/A","http://selleckchem.com/products/nsc348884.html","C38H40N10","free base","N/A","CC1=CC2=C(C=C1)N=C(CN(CCN(CC3=NC4=C([NH]3)C=C(C)C=C4)CC5=NC6=C([NH]5)C=C(C)C=C6)CC7=NC8=C([NH]7)C=C(C)C=C8)[NH]2",7.572,4,4,11]
["S8157","GDC-0326","c2","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GDC-0326 is a potent and selective inhibitor of PI3Kα with Ki value of 0.2 nM; remarkably selective over the other class I isoforms in enzymatic assays.",382.42,"1282514-88-8",{"v":76,"d":"76.00"},198.73,"<1","N/A","http://selleckchem.com/products/gdc-0326.html","C19H22N6O3","free base","N/A","CC(C)[N]1N=CN=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)OC(C)C(N)=O",2.017,6,1,5]
["S8163","Paxalisib (GDC-0084)","d2","L2600-11","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.",382.42,"1382979-44-3",{"v":8,"d":"8.00"},20.92,"<1","N/A","http://selleckchem.com/products/gdc-0084.html","C18H22N8O2","free base","RG7666","CC1(C)OCC[N]2C3=C(N=C12)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",0.588,7,1,2]
["S8165","Cucurbitacin B","e2","L2600-11","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of microtubule polymerization.",{"v":558.7,"d":"558.70"},"6199-67-3",{"v":100,"d":"100.00"},178.99,"<1","N/A","http://selleckchem.com/products/cucurbitacin-b.html","C32H46O8","free base","N/A","CC(=O)OC(C)(C)/C=C/C(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C",2.312,5,2,6]
["S8174","VO-Ohpic trihydrate","f2","L2600-11","in 10mM DMSO","PTEN","PI3K/Akt/mTOR","VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.",{"v":415.2,"d":"415.20"},"476310-60-8",{"v":72,"d":"72.00"},173.41,"<1","N/A","http://selleckchem.com/products/vo-ohpic.html","C12H9N2O8V.3H2O.H","trihydrate","N/A","O.O.O.OC1=CC=CN|2=C1C(=O)O[VH]3|2(O)(=O)OC(=O)C4=NC=CC=C4O3",-0.342,7,1,0]
["S8177","BH3I-1","g2","L2600-11","in 10mM DMSO","Bcl-2","Apoptosis","BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.",400.31,"300817-68-9",{"v":64,"d":"64.00"},159.88,"<1","N/A","http://selleckchem.com/products/bh3i-1.html","C15H14BrNO3S2","free base","N/A","CC(C)C(N1C(=S)S\\C(=C/C2=CC=C(Br)C=C2)C1=O)C(O)=O",4.604,2,0,4]
["S8181","SBI-0640756","h2","L2600-11","in 10mM DMSO","eIF","Cell Cycle","SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.",404.82,"1821280-29-8",{"v":80,"d":"80.00"},197.62,"<1","N/A","http://selleckchem.com/products/sbi-0640756.html","C23H14ClFN2O2","free base","N/A","FC1=CC(=CN=C1)\\C=C\\C(=O)C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(=C4)Cl",4.273,3,1,4]
["S8194","umbralisib (TGR-1202)","a3","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Umbralisib (TGR-1202, Rp-5264), a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively.",571.55,"1532533-67-7",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/tgr-1202.html","C31H24F3N5O3","free base","Rp-5264","CC(C)OC1=C(F)C=C(C=C1)C2=N[N](C(C)C3=C(C4=CC(=CC=C4)F)C(=O)C5=CC(=CC=C5O3)F)C6=C2C(=NC=N6)N",6.393,6,1,6]
["S8201","BI-78D3","b3","L2600-11","in 10mM DMSO","JNK","MAPK","BI-78D3 is a competitive JNK inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.",379.37,"883065-90-5",{"v":100,"d":"100.00"},263.59,"<1","N/A","http://selleckchem.com/products/bi-78d3.html","C13H9N5O5S2","free base","N/A","OC1=NN=C(SC2=NC=C(S2)[N+]([O-])=O)[N]1C3=CC=C4OCCOC4=C3",2.738,5,1,4]
["S8202","PF-06447475","c3","L2600-11","in 10mM DMSO","LRRK2","Autophagy","PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.",305.33,"1527473-33-1",{"v":61,"d":"61.00"},199.78,"<1","N/A","http://selleckchem.com/products/pf-06447475.html","C17H15N5O","free base","N/A","N#CC1=CC=CC(=C1)C2=C[NH]C3=NC=NC(=C23)N4CCOCC4",{"v":2.33,"d":"2.330"},3,1,2]
["S8222","AS1842856","d3","L2600-11","in 10mM DMSO","Autophagy,FOX","Metabolism","AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.",347.38,"836620-48-5",{"v":23,"d":"23.00"},66.21,"<1","N/A","http://selleckchem.com/products/as1842856.html","C18H22FN3O3","free base","N/A","CCN1C=C(C(O)=O)C(=O)C2=C(N)C(=C(NC3CCCCC3)C=C12)F",2.631,2,2,4]
["S8240","SMER28","e3","L2600-11","in 10mM DMSO","Autophagy","Autophagy","SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells.",264.12,"307538-42-7",{"v":52,"d":"52.00"},196.88,"<1","N/A","http://selleckchem.com/products/smer28.html","C11H10BrN3","free base","N/A","BrC1=CC=C2N=CN=C(NCC=C)C2=C1",3.101,2,1,3]
["S8275","Tomivosertib (eFT-508)","f3","L2600-11","in 10mM DMSO","eIF,MNK,PD-1/PD-L1","MAPK","Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.",340.38,"1849590-01-7",{"v":13,"d":"13.00"},38.19,"<1","N/A","http://selleckchem.com/products/eft-508.html","C17H20N6O2","free base","N/A","CC1=C2N(C(=O)C(=C1)NC3=NC=NC(=C3)N)C4(CCCCC4)NC2=O",0.717,4,3,2]
["S8298","CZ415","g3","L2600-11","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.",459.56,"1429639-50-8",{"v":91,"d":"91.00"},198.02,"<1","N/A","http://selleckchem.com/products/cz415.html","C22H29N5O4S","free base","N/A","CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C[S](=O)(=O)C3(C)C)C(=N2)N4CCOCC4C",{"v":2.2,"d":"2.200"},6,2,4]
["S8299","HA15","h3","L2600-11","in 10mM DMSO","HSP (HSP90)","ER stress & UPR","HA15 is a molecule that targets specifically HSPA5 (Heat shock 70kDa protein 5) also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.",466.58,"1609402-14-3",{"v":93,"d":"93.00"},199.32,"<1","N/A","http://selleckchem.com/products/ha15.html","C23H22N4O3S2","free base","N/A","CN(C)C1=CC=CC2=C1C=CC=C2[S](=O)(=O)NC3=CC(=CC=C3)C4=CSC(=N4)NC(C)=O",3.452,4,2,6]
["S8302","SR-12813","a4","L2600-11","in 10mM DMSO","HMG-CoA Reductase","Metabolism","SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.",504.53,"126411-39-0",{"v":100,"d":"100.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/sr-12813.html","C24H42O7P2","free base","N/A","CCO[P](=O)(OCC)C(=CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)[P](=O)(OCC)OCC",4.891,4,1,13]
["S8303","Kobe0065","b4","L2600-11","in 10mM DMSO","Ras","Cell Cycle","Kobe0065 is an H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.",449.79,"436133-68-5",{"v":89,"d":"89.00"},197.87,"<1","N/A","http://selleckchem.com/products/kobe0065.html","C15H11ClF3N5O4S","free base","N/A","CC1=C(Cl)C=C(NC(=S)NNC2=C(C=C(C=C2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)C=C1",5.921,0,3,8]
["S8304","Azoramide","c4","L2600-11","in 10mM DMSO","PERK","Apoptosis","Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.",308.83,"932986-18-0",{"v":61,"d":"61.00"},197.52,"<1","N/A","http://selleckchem.com/products/azoramide.html","C15H17ClN2OS","free base","N/A","CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(Cl)C=C2",3.588,2,1,6]
["S8309","ATI-2341","d4","L2600-11","in 10mM DMSO","CXCR","GPCR & G Protein","ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.",2256.82,"1337878-62-2",{"v":100,"d":"100.00"},44.31,"<1","N/A","http://selleckchem.com/products/ati-2341.html","C104H178N26O25S2","free base","N/A","CCCCCCCCCCCCCCCC(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=C(O)C=C2)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O",-5.119,19,28,89]
["S8317","3BDO","e4","L2600-11","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.",327.33,"890405-51-3",{"v":65,"d":"65.00"},198.58,"<1","N/A","http://selleckchem.com/products/3bdo.html","C18H17NO5","free base","3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one","[O-][N+](=O)C1=C(OCC2CC(CC3=CC=CC=C3)C(=O)O2)C=CC=C1",3.782,3,0,6]
["S8322","Samotolisib (LY3023414)","f4","L2600-11","in 10mM DMSO","DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.",406.48,"1386874-06-1",{"v":47,"d":"47.00"},115.63,"<1","N/A","http://selleckchem.com/products/ly3023414.html","C23H26N4O3","free base","GTPL8918","COC(C)CN1C(=O)N(C)C2=C1C3=CC(=CC=C3N=C2)C4=CC(=CN=C4)C(C)(C)O",1.883,4,0,5]
["S8330","Eganelisib (IPI-549)","g4","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Eganelisib (IPI-549) is a potent inhibitor of PI3K-γ with >100-fold selectivity over other lipid and protein kinases. The biochemical IC50 for PI3K-γ is 16 nM.",528.56,"1693758-51-8",{"v":100,"d":"100.00"},189.19,"<1","N/A","http://selleckchem.com/products/ipi-549.html","C30H24N8O2","free base","N/A","CC(NC(=O)C1=C2N=CC=C[N]2N=C1N)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)C#CC6=C[N](C)N=C6",2.732,5,2,6]
["S8335","PF-06409577","h4","L2600-11","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.",341.79,"1467057-23-3",{"v":68,"d":"68.00"},198.95,"<1","N/A","http://selleckchem.com/products/pf-06409577.html","C19H16ClNO3","free base","N/A","OC(=O)C1=C[NH]C2=CC(=C(C=C12)C3=CC=C(C=C3)C4(O)CCC4)Cl",4.133,1,1,3]
["S8355","APS-2-79 HCl","a5","L2600-11","in 10mM DMSO","MEK","MAPK","APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. IC50=120 ± 23 nM.",423.89,"2002381-31-7",{"v":97,"d":"97.00"},228.83,"<1","N/A","http://selleckchem.com/products/aps-2-79.html","C23H21N3O3.HCl","hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=C(OC4=CC=CC=C4)C=C3C",5.873,5,1,6]
["S8369","Lys05","b5","L2600-11","in 10mM DMSO","Autophagy","Autophagy","Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.",549.75,"1391426-24-6",{"v":9,"d":"9.00"},16.37,{"v":3,"d":"3.00"},5.46,"http://selleckchem.com/products/lys05.html","C23H23Cl2N5.3HCl","Trihydrochloride","N/A","Cl.Cl.Cl.CN(CCNC1=CC=NC2=C1C=CC(=C2)Cl)CCNC3=C4C=CC(=CC4=NC=C3)Cl",6.082,2,2,8]
["S8403","MX69","c5","L2600-11","in 10mM DMSO","MDM2/MDMX","Apoptosis","MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment.",474.57,"1005264-47-0",{"v":95,"d":"95.00"},200.18,"<1","N/A","http://selleckchem.com/products/mx69.html","C27H26N2O4S","free base","N/A","CC1=C(C)C=C(N[S](=O)(=O)C2=CC3=C(NC(C4CC=CC34)C5=CC=C(C=C5)C(O)=O)C=C2)C=C1",5.082,3,2,5]
["S8426","10074-G5","d5","L2600-11","in 10mM DMSO","Myc","Cell Cycle","10074-G5 is a c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 µM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC50 = 146 µM).",332.31,"413611-93-5",{"v":60,"d":"60.00"},180.55,"<1","N/A","http://selleckchem.com/products/10074-g5.html","C18H12N4O3","free base","N/A","[O-][N+](=O)C1=CC=C(NC2=C(C=CC=C2)C3=CC=CC=C3)C4=NON=C14",4.362,3,1,4]
["S8432","Troglitazone (CS-045)","e5","L2600-11","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,PPAR","Metabolism","Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced ferroptosis and lipid peroxidation in Pfa1 cells.",441.54,"97322-87-7",{"v":88,"d":"88.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/troglitazone-cs-045.html","C24H27NO5S","free base","Rezulin, Romglizone, Prelay, Romozin","CC1=C(O)C(=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C)C",5.682,4,2,5]
["S8456","VPS34 inhibitor 1 (Compound 19)","f5","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.",391.47,"1383716-46-8",{"v":78,"d":"78.00"},199.25,"<1","N/A","http://selleckchem.com/products/vps34-inhibitor-1.html","C21H25N7O","free base","PIK-III analogue","CC(C)(O)CNC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",2.798,5,2,8]
["S8464","Citarinostat (ACY-241)","g5","L2600-11","in 10mM DMSO","HDAC","Epigenetics","Citarinostat (ACY-241, HDAC-IN-2) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.",467.95,"1316215-12-9",{"v":41,"d":"41.00"},87.62,"<1","N/A","http://selleckchem.com/products/citarinostat-acy-241.html","C24H26ClN5O3","free base","HDAC-IN-2","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=C(Cl)C=CC=C3",4.582,4,2,11]
["S8483","CBL0137 HCl","h5","L2600-11","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8490","Tanzisertib(CC-930)","a6","L2600-11","in 10mM DMSO","JNK","MAPK","Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.",{"v":484.9,"d":"484.90"},"899805-25-5(freebase)",{"v":89,"d":"89.00"},183.54,{"v":4,"d":"4.00"},8.25,"http://selleckchem.com/products/cc-930.html","C21H23F3N6O2.HCl","hydrochloride","JNK-930, JNKI-1","Cl.OC1CCC(CC1)NC2=NC3=C(C=N2)N=C(NC4=C(F)C=C(F)C=C4F)[N]3C5CCOC5",3.791,4,3,5]
["S8493","PD-166866 (PD166866)","b6","L2600-11","in 10mM DMSO","FGFR","Angiogenesis","PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.",396.44,"192705-79-6",{"v":14,"d":"14.00"},35.31,"<1","N/A","http://selleckchem.com/products/pd-166866.html","C20H24N6O3","free base","N/A","COC1=CC(=CC(=C1)C2=CC3=C(N=C(N)N=C3)N=C2NC(=O)NC(C)(C)C)OC",2.279,6,3,5]
["S8534","Temuterkib (LY3214996)","c6","L2600-11","in 10mM DMSO","ERK","MAPK","Temuterkib (LY3214996) is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.",453.56,"1951483-29-6",{"v":27,"d":"27.00"},59.53,"<1","N/A","http://selleckchem.com/products/ly3214996.html","C22H27N7O2S","free base","N/A","C[N]1N=CC=C1NC2=NC(=CC=N2)C3=CC4=C(S3)C(C)(C)N(CCN5CCOCC5)C4=O",2.664,5,1,6]
["S8560","Seletalisib (UCB-5857)","d6","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).",482.85,"1362850-20-1",{"v":97,"d":"97.00"},200.89,"<1","N/A","http://www.selleckchem.com/products/seletalisib-ucb-5857.html","C23H14ClF3N6O","Free Base","N/A","[O-][N+]1=CC=CC(=C1)C2=NC3=C(Cl)C=CC=C3C=C2C(NC4=C5N=CC=CC5=NC=N4)C(F)(F)F",4.436,4,1,5]
["S8576","EAD1","e6","L2600-11","in 10mM DMSO","Autophagy","Autophagy","EAD1 is a potent autophagy inhibitor with an IC50 of 5.8 μM in the BxPC3 cells. It has antiproliferative activities in lung and pancreatic cancer cells.",598.45,"2320427-95-8",{"v":100,"d":"100.00"},{"v":167.1,"d":"167.10"},{"v":100,"d":"100.00"},{"v":167.1,"d":"167.10"},"http://selleckchem.com/products/ead1.html","C26H28Cl2F3N7O2","Trifluoroacetate","N/A","CN(CCNCC1=C[N](CC2=CC=C(Cl)C=C2)N=N1)CCNC3=CC=NC4=CC(=CC=C34)Cl.OC(=O)C(F)(F)F",2.308,4,2,12]
["S8580","COTI-2","f6","L2600-11","in 10mM DMSO","p53","Apoptosis","COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.",366.48,"1039455-84-9",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/coti-2.html","C19H22N6S","free base","N/A","S=C(N\\N=C/1CCCC2=C1N=CC=C2)N3CCN(CC3)C4=NC=CC=C4",3.825,3,1,4]
["S8581","Serabelisib (TAK-117)","g6","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.",363.37,"1268454-23-4",{"v":16,"d":"16.00"},44.03,"<1","N/A","http://selleckchem.com/products/tak-117-ink-1117-mln-1117.html","C19H17N5O3","free base","INK-1117, MLN-1117","NC1=NC2=C(O1)C=CC(=C2)C3=C[N]4C(=NC=C4C(=O)N5CCOCC5)C=C3",0.939,5,1,2]
["S8589","SF2523","h6","L2600-11","in 10mM DMSO","DNA-PK,Epigenetic Reader Domain,mTOR,PI3K","PI3K/Akt/mTOR","SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.",371.41,"1174428-47-7",{"v":29,"d":"29.00"},78.08,"<1","N/A","http://selleckchem.com/products/sf2523.html","C19H17NO5S","free base","N/A","O=C1C=C(OC2=C1SC=C2C3=CC=C4OCCOC4=C3)N5CCOCC5",3.081,5,0,2]
["S8596","Autophinib","a7","L2600-11","in 10mM DMSO","Autophagy,PI3K","Autophagy","Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.",346.73,"1644443-47-9",{"v":69,"d":"69.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/autophinib.html","C14H11ClN6O3","free base","N/A","CC1=CC(=N[NH]1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+]([O-])=O)Cl",4.118,4,2,5]
["S8597","LYN-1604","b7","L2600-11","in 10mM DMSO","Autophagy,ULK","Autophagy","LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.",657.54,"2088939-99-3",{"v":50,"d":"50.00"},76.04,{"v":100,"d":"100.00"},152.08,"http://selleckchem.com/products/lyn-1604.html","C33H45Cl4N3O2","dihydrochloride","N/A","Cl.Cl.CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(OCC2=CC=C3C=CC=CC3=C2)C4=CC=C(Cl)C=C4Cl",7.992,2,0,12]
["S8640","Reparixin (Repertaxin)","c7","L2600-11","in 10mM DMSO","CXCR","Immunology & Inflammation","Reparixin (Repertaxin, DF 1681Y) is a potent and specific inhibitor of CXCR1 with IC50 of 1 nM. Reparixin (Repertaxin) inhibits PMN migration induced by CXCL8 (IC50 = 1 nM) and rodent PMN chemotaxis induced by CXCL1 and CXCL2. Repertaxin inhibits the response of human PMN to CXCL1, which interacts with CXCR2 (IC50 = 400 nM).",283.39,"266359-83-5",{"v":56,"d":"56.00"},197.61,"<1","N/A","http://selleckchem.com/products/reparixin-repertaxin.html","C14H21NO3S","free base","DF 1681Y","CC(C)CC1=CC=C(C=C1)C(C)C(=O)N[S](C)(=O)=O",{"v":2.76,"d":"2.760"},3,1,5]
["S8654","ex229 (compound 991)","d7","L2600-11","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.",431.87,"1219739-36-2",{"v":12,"d":"12.00"},27.79,"<1","N/A","http://www.selleckchem.com/products/ex229-compound-991.html","C24H18ClN3O3","Free Base","N/A","C[N]1C=CC2=C1C=CC(=C2)C3=C(Cl)C=C4[NH]C(=NC4=C3)OC5=CC(=C(C)C=C5)C(O)=O",6.245,3,1,4]
["S8672","Tenalisib (RP6530)","e7","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.",415.42,"1639417-53-0",{"v":75,"d":"75.00"},180.54,"<1","N/A","http://selleckchem.com/products/tenalisib-rp6530.html","C23H18FN5O2","free base","N/A","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=C(C(=O)C4=CC=CC=C4O3)C5=CC=CC(=C5)F",{"v":4.07,"d":"4.070"},5,2,5]
["S8690","RAF709","f7","L2600-11","in 10mM DMSO","Raf","MAPK","RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.",542.55,"1628838-42-5",{"v":100,"d":"100.00"},184.31,"<1","N/A","http://selleckchem.com/products/raf709.html","C28H29F3N4O4","free base","N/A","CC1=NC=C(NC(=O)C2=CC=CC(=C2)C(F)(F)F)C=C1C3=CC(=C(OC4CCOCC4)N=C3)N5CCOCC5",{"v":3.27,"d":"3.270"},6,1,7]
["S8698","GLPG1837","g7","L2600-11","in 10mM DMSO","CFTR","Transmembrane Transporters","GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.",348.42,"1654725-02-6",{"v":69,"d":"69.00"},198.04,"<1","N/A","http://selleckchem.com/products/glpg1837.html","C16H20N4O3S","free base","ABBV-974","CC1(C)CC2=C(SC(=C2C(N)=O)NC(=O)C3=N[NH]C=C3)C(C)(C)O1",1.611,4,3,3]
["S8699","SNS-314 Mesylate","h7","L2600-11","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.",527.04,"1146618-41-8",{"v":100,"d":"100.00"},189.74,"<1","N/A","http://selleckchem.com/products/sns-314.html","C18H15ClN6OS2.CH4O3S","Mesylate","N/A","ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.953,4,3,6]
["S8706","UM-164","a8","L2600-11","in 10mM DMSO","p38 MAPK,Src","Protein Tyrosine Kinase","UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.",640.68,"903564-48-7",{"v":100,"d":"100.00"},156.08,"<1","N/A","http://selleckchem.com/products/um-164.html","C30H31F3N8O3S","free base","N/A","CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(F)(F)F)N5CCN(CCO)CC5",4.501,5,4,10]
["S8728","PK11000","b8","L2600-11","in 10mM DMSO","p53","Apoptosis","PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.",236.63,"38275-34-2",{"v":47,"d":"47.00"},198.62,{"v":47,"d":"47.00"},198.62,"https://www.selleckchem.com/products/pk11000.html","C6H5ClN2O4S","free base","N/A","C[S](=O)(=O)C1=NC=C(Cl)C(=N1)C(O)=O",{"v":0.82,"d":"0.820"},5,0,2]
["S8738","Bimiralisib (PQR309)","c8","L2600-11","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.",411.38,"1225037-39-7",{"v":6,"d":"6.00"},14.59,"<1","N/A","http://www.selleckchem.com/products/pqr309-bimiralisib.html","C17H20F3N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C(=C1)C(F)(F)F",1.891,6,1,4]
["S8744","PHY34","d8","L2600-11","in 10mM DMSO","Autophagy","Autophagy","PHY34 is a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo.",582.55,"2130033-55-3",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://www.selleckchem.com/products/phy34.html","C30H30O12","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=C3C(=O)OCC3=C2OC4OC(CO)C5OC(C)(C)OC5C4O)C6=CC=C7OCOC7=C6",2.164,10,2,6]
["S8745","Naporafenib (LXH254)","e8","L2600-11","in 10mM DMSO","Raf","MAPK","Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.",502.49,"1800398-38-2",{"v":100,"d":"100.00"},199.01,"<1","N/A","http://www.selleckchem.com/products/lxh254.html","C25H25F3N4O4","Free Base","N/A","CC1=CC=C(NC(=O)C2=CC(=NC=C2)C(F)(F)F)C=C1C3=CC(=NC(=C3)OCCO)N4CCOCC4",4.061,5,2,8]
["S8752","leniolisib (CDZ 173)","f8","L2600-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Leniolisib (CDZ 173) is a potent PI3Kδ selective inhibitor with biochemical IC50 values of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.",450.46,"1354690-24-6",{"v":90,"d":"90.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/leniolisib-cdz-173.html","C21H25F3N6O2","Free Base","N/A","CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(OC)N=C4)C(F)(F)F",{"v":2.65,"d":"2.650"},5,1,6]
["S8755","AZ304","g8","L2600-11","in 10mM DMSO","Raf","MAPK","AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies.",451.52,"942507-42-8",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://www.selleck.cn/products/az304.html","C27H25N5O2","free base","N/A","COC1=CC2=C(C=C1)C(=NC=N2)NC3=CC(=CC=C3C)NC(=O)C4=CC=CC(=C4)C(C)(C)C#N",5.524,4,2,6]
["S8764","IITZ-01","h8","L2600-11","in 10mM DMSO","Autophagy","Autophagy","IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.",482.51,"1807988-47-1",{"v":100,"d":"100.00"},207.25,"<1","N/A","http://www.selleckchem.com/products/iitz-01.html","C26H23FN8O","Free Base","N/A","FC1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)NC4=CC=C(C=C4)C5=NC6=C([NH]5)C=CC=C6)C=C1",6.104,5,3,6]
["S8793","ULK-101","a9","L2600-11","in 10mM DMSO","Autophagy,ULK","Autophagy","ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.",460.45,"2443816-45-1",{"v":92,"d":"92.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/ulk-101.html","C22H16F4N4OS","Free Base","N/A","FC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CSC(=C4)C(=O)NC(C5CC5)C(F)(F)F",4.363,3,1,6]
["S8795","FDL169","b9","L2600-11","in 10mM DMSO","CFTR","Transmembrane Transporters","FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.",486.49,"1628416-28-3",{"v":33,"d":"33.00"},67.83,"<1","N/A","http://www.selleck.cn/products/fdl169.html","C27H23FN4O4","Free Base","N/A","CCOC1=CC=C2C(=C1)C(=O)N(CC(=O)N(C)C3=CC=C4N=C(C)OC4=C3)N=C2C5=CC(=CC=C5)F",{"v":3.87,"d":"3.870"},6,0,6]
["S8801","CC-90003","c9","L2600-11","in 10mM DMSO","ERK","MAPK","CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay.",458.44,"1621999-82-3",{"v":92,"d":"92.00"},200.68,"<1","N/A","http://www.selleckchem.com/products/cc-90003.html","C22H21F3N6O2","Free Base","N/A","COC1=CC(=C(C)C=N1)NC2=NC(=C(C=N2)C(F)(F)F)NC3=C(NC(=O)C=C)C=C(C)C=C3",5.316,5,3,8]
["S8803","MK-3903","d9","L2600-11","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.",{"v":454.9,"d":"454.90"},"1219737-12-8",{"v":91,"d":"91.00"},200.04,"<1","N/A","http://www.selleckchem.com/products/mk-3903.html","C27H19ClN2O3","Free Base","N/A","CC1=CC=C(OC2=NC3=CC(=C(C=C3[NH]2)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C=C1C(O)=O",7.264,3,1,5]
["S8807","PFK158","e9","L2600-11","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.",328.29,"1462249-75-7",{"v":14,"d":"14.00"},42.65,"<1","N/A","http://www.selleck.cn/products/pfk158.html","C18H11F3N2O","free base","N/A","FC(F)(F)C1=CC=C2C=CC(=NC2=C1)\\C=C\\C(=O)C3=CC=NC=C3",4.108,3,0,4]
["S8808","DC661","f9","L2600-11","in 10mM DMSO","Apoptosis related,Autophagy","Autophagy","DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis.",552.58,"1872387-43-3",{"v":62,"d":"62.00"},{"v":112.2,"d":"112.20"},"<1","N/A","http://www.selleck.cn/products/dc661.html","C31H39Cl2N5","free base","N/A","CN(CCCCCCNC1=CC=NC2=CC(=CC=C12)Cl)CCCCCCNC3=CC=NC4=C3C=CC(=C4)Cl",8.045,2,2,16]
["S8813","LIT-927","g9","L2600-11","in 10mM DMSO","CXCR","Immunology & Inflammation","LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.",328.75,"2172879-52-4",{"v":66,"d":"66.00"},200.76,"<1","N/A","http://www.selleckchem.com/products/lit-927.html","C17H13ClN2O3","Free Base","N/A","COC1=CC(=CC=C1O)C2=CC(=NC(=O)N2)C3=CC=C(Cl)C=C3",3.599,3,2,3]
["S9031","Gambogenic acid","h9","L2600-11","in 10mM DMSO","EZH1/2,FGFR","Angiogenesis","Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.",630.77,"173932-75-7",{"v":10,"d":"10.00"},15.85,"N/A","N/A","https://www.selleckchem.com/products/gambogenic-acid.html","C38H46O8","free base","N/A","CC(C)=CCC/C(C)=C/CC1=C(O)C2=C(OC34C5CC(C=C3C2=O)C(=O)C4(C\\C=C(\\C)C(O)=O)OC5(C)C)C(=C1O)CC=C(C)C",7.717,5,2,10]
["S9041","Corosolic acid","a10","L2600-11","in 10mM DMSO","NF-κB","NF-κB","Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells.",{"v":472.7,"d":"472.70"},"4547-24-4",{"v":95,"d":"95.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/corosolic-acid.html","C30H48O4","free base","Glucosol, Colosic acid, 2α-Hydroxyursolic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",5.525,1,2,1]
["S9043","6-Shogaol","b10","L2600-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.,",276.37,"555-66-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/6-shogaol.html","C17H24O3","free base","FS42771","CCCCC/C=C/C(=O)CCC1=CC=C(O)C(=C1)OC",4.717,2,1,9]
["S9047","Leonurine Hydrochloride","c10","L2600-11","in 10mM DMSO","Others","Others","Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.",347.79,"24735-18-0",{"v":70,"d":"70.00"},201.27,"N/A","N/A","https://www.selleckchem.com/products/leonurine-hydrochloride.html","C14H22ClN3O5","free base","SCM-198 HCl","Cl.COC1=C(O)C(=CC(=C1)C(=O)OCCCCNC(N)=N)OC",1.472,4,3,10]
["S9068","Trillin","d10","L2600-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Trillin (Disogluside, Diosgenin glucoside) is an active ingredient isolated from Trillium tschonoshii Maxim and acts as a potential anti-inflammatory drug for chronic hepatic inflammation.",576.76,"14144-06-0",{"v":10,"d":"10.00"},17.34,"N/A","N/A","https://www.selleckchem.com/products/trillin.html","C33H52O8","free base","Disogluside, Diosgenin glucoside","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(O)C7O",2.887,4,4,3]
["S9076","Typhaneoside","e10","L2600-11","in 10mM DMSO","Others","Others","Typhaneoside is a flavonoid glycoside plant extract that has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cell(HUASMC).",770.69,"104472-68-6",{"v":10,"d":"10.00"},12.98,"N/A","N/A","https://www.selleckchem.com/products/typhaneoside.html","C34H42O20","free base/Hcl salt","Isorhamnetin 3-O-2G-rhamnosylrutinoside; Isorhamnetin-3-O-(2'', 6''-di-O-a-L-rhamnopyranosyl)-b-D-glucopyranoside","COC1=CC(=CC=C1O)C2=C(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3OC5OC(C)C(O)C(O)C5O)C(=O)C6=C(O2)C=C(O)C=C6O",-1.791,9,11,9]
["S9080","Anhydroicaritin","f10","L2600-11","in 10mM DMSO","Others","Apoptosis","Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.",368.38,"118525-40-9",{"v":10,"d":"10.00"},27.15,"N/A","N/A","https://www.selleckchem.com/products/anhydroicaritin.html","C21H20O6","free base","Cycloicaritin","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C(=C3O2)CC=C(C)C",3.954,3,3,4]
["S9084","Rhoifolin","g10","L2600-11","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.",578.52,"17306-46-6",{"v":10,"d":"10.00"},17.29,"N/A","N/A","https://www.selleckchem.com/products/rhoifolin.html","C27H30O14","free base","Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC4=C(C(=C3)O)C(=O)C=C(O4)C5=CC=C(O)C=C5)C(O)C(O)C1O",-0.378,6,8,6]
["S9114","Polyphyllin I","h10","L2600-11","in 10mM DMSO","JNK","MAPK","Polyphyllin I, a small molecular monomer extracted from Rhizoma of Paris polyphyllin, is used in the treatment of infectious disease and cancer. Polyphyllin I inhibits proliferation and induces apoptotic cell death in U251 cells. Polyphyllin I is an activator of the JNK signaling pathway with a potential anti-glioma effect.",855.02,"50773-41-6",{"v":100,"d":"100.00"},116.96,"N/A","N/A","https://www.selleckchem.com/products/polyphyllin-i.html","C44H70O16","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(CO)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",0.792,8,8,8]
["S9115","Wogonoside","a11","L2600-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.",460.39,"51059-44-0",{"v":38,"d":"38.00"},82.54,"N/A","N/A","https://www.selleckchem.com/products/wogonoside.html","C22H20O11","free base","Oroxindin, Wogonin 7-O-glucuronide, Glychionide B","COC1=C(OC2OC(C(O)C(O)C2O)C(O)=O)C=C(O)C3=C1OC(=CC3=O)C4=CC=CC=C4",0.833,6,4,5]
["S9118","Beta-Asarone","b11","L2600-11","in 10mM DMSO","Others","Others","Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.",208.25,"5273-86-9","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/beta-asarone.html","C12H16O3","free base","N/A","COC1=CC(=C(\\C=C/C)C=C1OC)OC",2.734,3,0,4]
["S9120","Scutellarein","c11","L2600-11","in 10mM DMSO","Antiviral,Immunology & Inflammation related","Immunology & Inflammation","Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities",286.24,"529-53-3",{"v":57,"d":"57.00"},199.14,"N/A","N/A","https://www.selleckchem.com/products/scutellarein.html","C15H10O6","free base/salt","6-Hydroxyapigenin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)O",2.168,2,4,1]
["S9126","Schizandrol B","d11","L2600-11","in 10mM DMSO","Others","Others","Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.",416.46,"58546-54-6",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/schizandrol-b.html","C23H28O7","free base","Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)(O)C2)C=C4OCOC4=C3OC",3.851,6,0,4]
["S9141","Berbamine","e11","L2600-11","in 10mM DMSO","Apoptosis related,Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",608.72,"478-61-5",{"v":100,"d":"100.00"},164.28,"N/A","N/A","https://www.selleckchem.com/products/berbamine.html","C37H40N2O6","free base","BA, BBM","COC1=C2OC3=C4C(CC5=CC=C(O)C(=C5)OC6=CC=C(CC7N(C)CCC(=C1)C7=C2)C=C6)N(C)CCC4=CC(=C3OC)OC",6.992,5,1,3]
["S9148","Peiminine","f11","L2600-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.",429.64,"18059-10-4",{"v":85.9,"d":"85.90"},199.94,"N/A","N/A","https://www.selleckchem.com/products/peiminine.html","C27H43NO3","free base","Verticinone, Zhebeinone, Raddeanine","CC1CCC2N(C1)CC3C4CC5C(CC(=O)C6CC(O)CCC56C)C4CCC3C2(C)O",3.354,1,1,0]
["S9150","Daurisoline","g11","L2600-11","in 10mM DMSO","Autophagy","Autophagy","Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.",610.74,"70553-76-3",{"v":64,"d":"64.00"},104.79,"N/A","N/A","https://www.selleckchem.com/products/daurisoline.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1O)C(CC3=CC(=C(O)C=C3)OC4=CC=C(CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C=C4)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9160","Ziyu-glycoside I","h11","L2600-11","in 10mM DMSO","Others","Others","Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.",766.95,"35286-58-9",{"v":100,"d":"100.00"},130.39,"N/A","N/A","https://www.selleckchem.com/products/ziyu-glycoside-i.html","C41H66O13","free base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1(C)O)C(=O)OC7OC(CO)C(O)C(O)C7O",2.178,5,7,6]
["S9172","Phellodendrine","a2","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.",342.41,"6873-13-8",{"v":42.6,"d":"42.60"},124.41,"N/A","N/A","https://www.selleckchem.com/products/phellodendrine.html","C20H24NO4","free base","N/A","COC1=C(O)C=C2C3CC4=C(C[N+]3(C)CCC2=C1)C=C(OC)C(=C4)O",1.793,2,2,2]
["S9190","Oroxin B","b2","L2600-12","in 10mM DMSO","Akt,Apoptosis related,COX,PI3K,PTEN","Apoptosis","Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.",594.52,"114482-86-9",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-b.html","C27H30O15","free base","Hypocretin-2","OCC1OC(OCC2OC(OC3=C(O)C(=C4C(=O)C=C(OC4=C3)C5=CC=CC=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.267,6,9,7]
["S9204","Oroxylin A","c2","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.",284.26,"480-11-5",{"v":56.9,"d":"56.90"},200.17,"N/A","N/A","https://www.selleckchem.com/products/oroxylin-a.html","C16H12O5","free base","6-Methoxybaicalein","COC1=C(O)C2=C(OC(=CC2=O)C3=CC=CC=C3)C=C1O",2.636,3,2,2]
["S9221","Ferulaldehyde","d2","L2600-12","in 10mM DMSO","Heme Oxygenase","Immunology & Inflammation","Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.",178.18,"458-36-6",{"v":35,"d":"35.00"},196.43,"N/A","N/A","https://www.selleckchem.com/products/ferulaldehyde.html","C10H10O3","free base","Coniferaldehyde, Ferulyl aldehyde","COC1=CC(=CC=C1O)\\C=C\\C=O",1.691,2,1,3]
["S9234","Schaftoside","e2","L2600-12","in 10mM DMSO","Lipase,MyD88,TLR","Metabolism","Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.",564.49,"51938-32-0",{"v":100,"d":"100.00"},177.15,"N/A","N/A","https://www.selleckchem.com/products/schaftoside.html","C26H28O14","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC=C(O)C=C4)C(=C2O)C5OCC(O)C(O)C5O",-1.862,4,10,4]
["S9240","Isofraxidin","f2","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.",222.19,"486-21-5",{"v":44,"d":"44.00"},198.03,"N/A","N/A","https://www.selleckchem.com/products/isofraxidin.html","C11H10O5","free base","6,8-Dimethoxyumbelliferone","COC1=CC2=C(OC(=O)C=C2)C(=C1O)OC",1.625,4,1,2]
["S9243","Protosappanin B","g2","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.",304.29,"102036-29-3",{"v":61,"d":"61.00"},200.46,"N/A","N/A","https://www.selleckchem.com/products/protosappanin-b.html","C16H16O6","free base","FT-0689654, Q-100961","OCC1(O)COC2=CC(=CC=C2C3=CC(=C(O)C=C3C1)O)O",1.486,1,4,1]
["S9277","Alisol A","h2","L2600-12","in 10mM DMSO","Others","Metabolism","Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes.",490.71,"19885-10-0",{"v":98,"d":"98.00"},199.71,"N/A","N/A","https://www.selleckchem.com/products/alisol-a.html","C30H50O5","free base","N/A","CC(CC(O)C(O)C(C)(C)O)C1=C2CC(O)C3C4(C)CCC(=O)C(C)(C)C4CCC3(C)C2(C)CC1",4.015,1,3,5]
["S9280","Demethoxycurcumin","a3","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.",338.35,"22608-11-3",{"v":68,"d":"68.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/demethoxycurcumin.html","C20H18O5","free base","N/A","COC1=CC(=CC=C1O)\\C=C\\C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",{"v":3.57,"d":"3.570"},3,2,7]
["S9293","Isoliquiritin","b3","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.",418.39,"5041-81-6",{"v":84,"d":"84.00"},200.77,"N/A","N/A","https://www.selleckchem.com/products/isoliquiritin.html","C21H22O9","free base","Neoisoliquritin","OCC1OC(OC2=CC=C(\\C=C\\C(=O)C3=C(O)C=C(O)C=C3)C=C2)C(O)C(O)C1O",1.046,3,6,6]
["S9309","Micheliolide","c3","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.",248.32,"68370-47-8",{"v":49,"d":"49.00"},197.33,"N/A","N/A","https://www.selleckchem.com/products/micheliolide.html","C15H20O3","free base","N/A","CC1=C2CCC(C)(O)C2C3OC(=O)C(=C)C3CC1",{"v":2.34,"d":"2.340"},2,0,0]
["S9310","Isorhychophylline","d3","L2600-12","in 10mM DMSO","Autophagy","Autophagy","Isorhynchophylline (IsoRhy, 7-Isorhyncophylline) is a major tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla (Miq.)Jacks (Gouteng in Chinese). It acts as a neuronal autophagy inducer with therapeutic potential for cardiovascular and central nervous system diseases.",384.47,"6859-01-4",{"v":77,"d":"77.00"},200.28,"N/A","N/A","https://www.selleckchem.com/products/isorhychophylline.html","C22H28N2O4","free base","IsoRhy, 7-Isorhyncophylline","CCC1CN2CCC3(C2CC1\\C(=C/OC)C(=O)OC)C(=O)NC4=CC=CC=C34",2.103,4,1,5]
["S9314","Atractylenolide II","e3","L2600-12","in 10mM DMSO","Others","Others","Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.",232.32,"73069-14-4",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"N/A","N/A","https://www.selleckchem.com/products/atractylenolide-ii.html","C15H20O2","free base","Asterolide, 2-Atractylenolide","CC1=C2CC3C(=C)CCCC3(C)CC2OC1=O",3.573,2,0,0]
["S9384","Sophocarpine Monohydrate","f3","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.",264.36,"145572-44-7",{"v":52,"d":"52.00"},{"v":196.7,"d":"196.70"},"N/A","N/A","https://www.selleckchem.com/products/sophocarpine-monohydrate.html","C15H24N2O2","free base","N/A","O.O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.187,1,0,0]
["S9408","Beta-Elemonic acid","g3","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.",454.68,"28282-25-9",{"v":35,"d":"35.00"},76.98,"N/A","N/A","https://www.selleckchem.com/products/beta-elemonic.html","C30H46O3","free base","3-Oxotirucallenoic Acid","CC(C)=CCCC(C1CCC2(C)C3=C(CCC12C)C4(C)CCC(=O)C(C)(C)C4CC3)C(O)=O",7.153,2,0,5]
["S9411","Liensinine","h3","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"2586-96-1",{"v":100,"d":"100.00"},163.74,"N/A","N/A","https://www.selleckchem.com/products/liensinine.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9413","Yangonin","a4","L2600-12","in 10mM DMSO","Cannabinoid Receptor,Fungal","GPCR & G Protein","Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.",258.27,"500-62-9",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/yangonin.html","C15H14O4","free base","Y100550","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=O)O2)OC",2.211,4,0,4]
["S9424","Liensinine diperchlorate","b4","L2600-12","in 10mM DMSO","Autophagy,Mitophagy","Autophagy","Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.",811.66,"5088-90-4",{"v":50,"d":"50.00"},{"v":61.6,"d":"61.60"},"N/A","N/A","https://www.selleckchem.com/products/liensinine-diperchlorate.html","C37H44Cl2N2O14","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC(=C(O)C=C3)OC4=C(OC)C=C5CCN(C)C(CC6=CC=C(O)C=C6)C5=C4)N(C)CC2.O[Cl](=O)(=O)=O.O[Cl](=O)(=O)=O",7.669,4,2,9]
["S9428","Brazilin","c4","L2600-12","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.",286.28,"474-07-7",{"v":57,"d":"57.00"},199.11,"N/A","N/A","https://www.selleckchem.com/products/brazilin.html","C16H14O5","free base","Natural Red 24","OC1=CC2=C(C=C1)C3C4=CC(=C(O)C=C4CC3(O)CO2)O",1.933,1,3,0]
["S9431","Dehydrocorydalin","d4","L2600-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.",366.43,"30045-16-0",{"v":73,"d":"73.00"},199.22,"N/A","N/A","https://www.selleckchem.com/products/dehydrocorydalin.html","C22H24NO4","free base","N/A","COC1=CC=C2C(=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC)C",4.648,4,0,4]
["S9503","Fraxetin","e4","L2600-12","in 10mM DMSO","Heme Oxygenase","Apoptosis","Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.",208.17,"574-84-5",{"v":42,"d":"42.00"},201.76,"N/A","N/A","https://www.selleckchem.com/products/fraxetin.html","C10H8O5","free base","7,8-dihydroxy-6-methoxy coumarin","COC1=CC2=C(OC(=O)C=C2)C(=C1O)O","N/A","N/A","N/A","N/A"]
["S9507","(−)-Norepinephrine","f4","L2600-12","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.",169.18,"51-41-2",{"v":11,"d":"11.00"},65.02,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/norepinephrine.html","C8H11NO3","Free Base","Arterenol, Levarterenol, L-Noradrenaline","NCC(O)C1=CC(=C(O)C=C1)O",-0.059,0,4,2]
["S2931","Aurora Kinase Inhibitor III","g4","L2600-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively).",{"v":413.4,"d":"413.40"},"879127-16-9",{"v":83,"d":"83.00"},200.77,"<1","N/A","http://www.selleck.cn/products/aurora-kinase-inhibitor-iii.html","C21H18F3N5O","Free Base","N/A","FC(F)(F)C1=CC(=CC=C1)NC2=CC=NC(=N2)NC3=CC(=CC=C3)NC(=O)C4CC4",5.032,3,3,7]
["S2933","AM580","h4","L2600-12","in 10mM DMSO","Retinoid Receptor","Metabolism","AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.",351.44,"102121-60-8",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://www.selleck.cn/products/am580.html","C22H25NO3","Free Base","N/A","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S6534","CZC-54252","a5","L2600-12","in 10mM DMSO","LRRK2","Autophagy","CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.",504.99,"1191911-27-9",{"v":100,"d":"100.00"},198.02,"<1","N/A","http://www.selleck.cn/products/czc-54252.html","C22H25ClN6O4S","Free Base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3N[S](C)(=O)=O)C=CC(=C1)N4CCOCC4",{"v":3.62,"d":"3.620"},6,3,8]
["S6599","KM11060","b5","L2600-12","in 10mM DMSO","CFTR","Transmembrane Transporters","KM11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation.",422.33,"774549-97-2",{"v":84,"d":"84.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://www.selleck.cn/products/km11060.html","C19H17Cl2N3O2S","Free Base","N/A","ClC1=CC=C(C=C1)[S](=O)(=O)N2CCN(CC2)C3=CC=NC4=C3C=CC(=C4)Cl",4.091,3,0,3]
["S6617","MSX-122","c5","L2600-12","in 10mM DMSO","CXCR","Immunology & Inflammation","MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).",292.34,"897657-95-3",{"v":3,"d":"3.00"},10.26,"<1","N/A","http://www.selleck.cn/products/msx-122.html","C16H16N6","Free Base","Q-122","C(NC1=NC=CC=N1)C2=CC=C(CNC3=NC=CC=N3)C=C2",2.099,4,2,6]
["S6620","Danirixin (GSK1325756)","d5","L2600-12","in 10mM DMSO","CXCR,Interleukins","Immunology & Inflammation","Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 (IL-8) binding = 12.5 nM), selective, and reversible CXCR2 antagonist.",{"v":441.9,"d":"441.90"},"954126-98-8",{"v":88,"d":"88.00"},199.14,"<1","N/A","http://www.selleck.cn/products/danirixin.html","C19H21ClFN3O4S","Free Base","N/A","CC1=C(NC(=O)NC2=C(O)C(=C(Cl)C=C2)[S](=O)(=O)C3CCCNC3)C=CC=C1F",3.255,3,4,4]
["S6645","AZD5069","e5","L2600-12","in 10mM DMSO","CXCR","Immunology & Inflammation","AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.",476.52,"878385-84-3",{"v":95,"d":"95.00"},199.36,"<1","N/A","http://www.selleck.cn/products/azd-5069.html","C18H22F2N4O5S2","Free Base","N/A","CC(OC1=NC(=NC(=C1)N[S](=O)(=O)N2CCC2)SCC3=C(F)C(=CC=C3)F)C(O)CO",{"v":1.88,"d":"1.880"},5,3,10]
["S6716","NSC 185058","f5","L2600-12","in 10mM DMSO","Autophagy","Autophagy","NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways.",215.27,"39122-38-8",{"v":43,"d":"43.00"},199.75,"<1","N/A","http://www.selleck.cn/products/nsc-185058.html","C11H9N3S","Free Base","N/A","S=C(NC1=NC=CC=C1)C2=NC=CC=C2",2.652,2,1,3]
["S6744","Inauhzin","g5","L2600-12","in 10mM DMSO","Sirtuin","Epigenetics","Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.",469.58,"309271-94-1",{"v":94,"d":"94.00"},200.18,"<1","N/A","http://www.selleck.cn/products/inauhzin.html","C25H19N5OS2","Free Base","N/A","CCC(SC1=NN=C2C(=N1)[NH]C3=C2C=CC=C3)C(=O)N4C5=C(SC6=CC=CC=C46)C=CC=C5",6.482,4,1,4]
["S6751","Brevianamide F","h5","L2600-12","in 10mM DMSO","Others","Others","Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..",283.33,"38136-70-8",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://www.selleck.cn/products/brevianamide-f.html","C16H17N3O2","Free Base","N/A","O=C1NC(CC2=C[NH]C3=C2C=CC=C3)C(=O)N4CCCC14",1.255,2,2,2]
["S8506","Navarixin (SCH-527123)","a6","L2600-12","in 10mM DMSO","CXCR","Immunology & Inflammation","Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.",397.42,"473727-83-2",{"v":79,"d":"79.00"},198.78,"<1","N/A","http://www.selleck.cn/products/sch-527123.html","C21H23N3O5","Free Base","MK-7123, PS-291822","CCC(NC1=C(NC2=C(O)C(=CC=C2)C(=O)N(C)C)C(=O)C1=O)C3=CC=C(C)O3",1.635,4,3,7]
["S8839","Borussertib","b6","L2600-12","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Borussertib is a covalent-allosteric inhibitor of protein kinase Akt with an IC50 of 0.8 nM and a Ki of 2.2 nM for WT Akt.",596.68,"1800070-77-2",{"v":100,"d":"100.00"},167.59,"<1","N/A","http://www.selleck.cn/products/borussertib.html","C36H32N6O3","Free Base","N/A","C=CC(=O)NC1=CC2=C(NC(=O)N2C3CCN(CC3)CC4=CC=C(C=C4)C5=NC6=C(C=C5C7=CC=CC=C7)C(=O)NC=C6)C=C1",4.051,4,3,7]
["S9086","Dihydrocapsaicin","c6","L2600-12","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.DHC is a selective TRPV1 agonist.",307.43,"19408-84-5",{"v":10,"d":"10.00"},32.53,"N/A","N/A","https://www.selleckchem.com/products/dihydrocapsaicin.html","C18H29NO3","free base","6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589","COC1=C(O)C=CC(=C1)CNC(=O)CCCCCCC(C)C",4.354,2,2,10]
["S9102","Magnolin","d6","L2600-12","in 10mM DMSO","ERK","MAPK","Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).",416.46,"31008-18-1",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/magnolin.html","C23H28O7","free Base","N/A","COC1=C(OC)C=C(C=C1)C2OCC3C2COC3C4=CC(=C(OC)C(=C4)OC)OC",2.618,7,0,7]
["S9111","Isorhamnetin","e6","L2600-12","in 10mM DMSO","Tyrosinase","Proteases","Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.",316.26,"480-19-3",{"v":63,"d":"63.00"},{"v":199.2,"d":"199.20"},"N/A","N/A","https://www.selleckchem.com/products/isorhamnetin.html","C16H12O7","free base","3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol","COC1=C(O)C=CC(=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",1.856,3,4,2]
["S2002","CZC-25146","f6","L2600-12","in 10mM DMSO","LRRK2","Autophagy","CZC-25146 is a potent and selective LRRK2 inhibitor with IC50 of 4.76 nM and 6.87 nM for human wild type LRRK2 and G2019S LRRK2, respectively.",488.54,"1191911-26-8",{"v":98,"d":"98.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://www.selleck.cn/products/czc-25146.html","C22H25FN6O4S","Free Base","N/A","COC1=CC(=CC=C1NC2=NC=C(F)C(=N2)NC3=CC=CC=C3N[S](C)(=O)=O)N4CCOCC4",3.161,6,3,8]
["S2421","PF-04457845","g6","L2600-12","in 10mM DMSO","FAAH","Metabolism","PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.",455.43,"1020315-31-4",{"v":91,"d":"91.00"},199.81,"<1","N/A","https://www.selleckchem.com/products/pf-04457845.html","C23H20F3N5O2","Free Base","PF-4457845","FC(F)(F)C1=CN=C(OC2=CC(=CC=C2)C=C3CCN(CC3)C(=O)NC4=NN=CC=C4)C=C1",4.371,5,1,5]
["S6650","EN6","h6","L2600-12","in 10mM DMSO","Autophagy","Autophagy","EN6 is a novel covalent autophagy activator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein.",368.34,"1808714-73-9",{"v":74,"d":"74.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://www.selleck.cn/products/en6.html","C19H14F2N4O2","Free Base","N/A","FC1=C(NC(=O)C=C)C=C(NC(=O)C2=C[N](N=C2)C3=CC=CC=C3F)C=C1",{"v":3.07,"d":"3.070"},3,2,5]
["S6680","L-779450","a7","L2600-12","in 10mM DMSO","Raf","MAPK","L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM.",{"v":347.8,"d":"347.80"},"303727-31-3",{"v":70,"d":"70.00"},201.27,"<1","N/A","http://www.selleck.cn/products/l-779450.html","C20H14ClN3O","Free Base","L-779,450","OC1=CC(=CC=C1Cl)C2=C(N=C([NH]2)C3=CC=CC=C3)C4=CC=NC=C4",{"v":4.67,"d":"4.670"},2,2,3]
["S8500","BAY1125976","b7","L2600-12","in 10mM DMSO","Akt","PI3K/Akt/mTOR","BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).",383.45,"1402608-02-9",{"v":11,"d":"11.00"},28.69,"<1","N/A","http://www.selleck.cn/products/bay1125976.html","C23H21N5O","Free Base","N/A","NC(=O)C1=N[N]2C(=NC(=C2C3=CC=CC=C3)C4=CC=C(C=C4)C5(N)CCC5)C=C1",3.335,3,2,4]
["S8909","UBCS039","c7","L2600-12","in 10mM DMSO","Sirtuin","Epigenetics","UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.",247.29,"358721-70-7",{"v":49,"d":"49.00"},198.15,"<1","N/A","http://www.selleck.cn/products/ubcs039.html","C16H13N3","Free Base","N/A","N1C(C2=CN=CC=C2)C3=CC=C[N]3C4=CC=CC=C14",2.914,1,1,1]
["S9044","Ginsenoside F2","d7","L2600-12","in 10mM DMSO","Others","Others","Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.",785.01,"62025-49-4",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleck.cn/products/ginsenoside-f2.html","C42H72O13","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C",2.295,4,9,10]
["S2427","Triglycidyl Isocyanurate (Teroxirone)","e7","L2600-12","in 10mM DMSO","DNA/RNA Synthesis,p53","Apoptosis","Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.",297.26,"2451-62-9",{"v":59,"d":"59.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/triglycidyl-isocyanurat.html","C12H15N3O6","Free Base","Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC","O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4",-0.894,6,0,6]
["S5183","PD 169316","f7","L2600-12","in 10mM DMSO","Enterovirus,p38 MAPK,TGF-beta/Smad","MAPK","PD 169316 is a potent, selective and cell-permeable p38 MAP kinase inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both TGFbeta and Activin A. PD169316 shows antiviral activity against Enterovirus71.",360.34,"152121-53-4",{"v":14,"d":"14.00"},38.85,"<1","N/A","http://www.selleckchem.com/products/pd-169316.html","C20H13FN4O2","Free Base","N/A","[O-][N+](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",4.348,2,1,4]
["S6787","KN-93","g7","L2600-12","in 10mM DMSO","CaMK","Neuronal Signaling","KN-93 is a cell-permeable, reversible and competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with Ki of 2.58 μM at rabbit myocardial CaM kinase activity.",501.04,"139298-40-1",{"v":100,"d":"100.00"},199.58,"<1","N/A","http://www.selleckchem.com/products/kn-93.html","C26H29ClN2O4S","Free Base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)N(CCO)C2=CC=CC=C2CN(C)C\\C=C\\C3=CC=C(Cl)C=C3",4.757,3,1,11]
["S6797","QX77","h7","L2600-12","in 10mM DMSO","Autophagy","Autophagy","QX77 is a novel activator of chaperone-mediated autophagy (CMA). QX77 induces the up-regulation of Rab11 expression and up-regulates LAMP2A expression.",300.74,"1798331-92-6",{"v":60,"d":"60.00"},199.51,"<1","N/A","http://www.selleckchem.com/products/qx77.html","C16H13ClN2O2","Free Base","N/A","CC(=O)NC1=CC=C(C=C1)C2=NC3=C(OC2)C=C(Cl)C=C3",2.861,3,1,2]
["S6804","CX546","a8","L2600-12","in 10mM DMSO","GluR","Neuronal Signaling","CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator.",247.29,"215923-54-9",{"v":49,"d":"49.00"},198.15,"<1","N/A","http://www.selleckchem.com/products/cx546.html","C14H17NO3","Free Base","N/A","O=C(N1CCCCC1)C2=CC=C3OCCOC3=C2",1.947,3,0,1]
["S6807","TA-02","b8","L2600-12","in 10mM DMSO","p38 MAPK,TGF-beta/Smad","MAPK","TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2.",333.33,"1784751-19-4",{"v":67,"d":"67.00"},{"v":201,"d":"201.00"},"<1","N/A","http://www.selleckchem.com/products/ta-02.html","C20H13F2N3","Free Base","N/A","FC1=CC=C(C=C1)C2=C([NH]C(=N2)C3=CC=CC=C3F)C4=CC=NC=C4",4.659,2,1,3]
["S7862","Rottlerin","c8","L2600-12","in 10mM DMSO","PKC","TGF-beta/Smad","Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ(from baculovirus-infected Sf9 insect cells), PKCδ(from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.",516.54,"82-08-6",{"v":11,"d":"11.00"},{"v":21.3,"d":"21.30"},"˂1","N/A","http://www.selleckchem.com/products/rottlerin.html","C30H28O8","Free Base","Mallotoxin, NSC 56346, NSC 94525","CC(=O)C1=C(O)C(=C(O)C(=C1O)C)CC2=C(O)C(=C3OC(C)(C)C=CC3=C2O)C(=O)\\C=C\\C4=CC=CC=C4",{"v":5.48,"d":"5.480"},3,5,6]
["S8784","PQR620","d8","L2600-12","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.",445.47,"1927857-56-4",{"v":20,"d":"20.00"},{"v":44.9,"d":"44.90"},"˂1","N/A","http://www.selleckchem.com/products/pqr620.html","C21H25F2N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3C4CCC3COC4)N5C6CCC5COC6)C(=C1)C(F)F",2.434,6,1,4]
["S8943","VLX600","e8","L2600-12","in 10mM DMSO","Autophagy,Mitochondrial Metabolism,OXPHOS","Apoptosis","VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.",317.35,"327031-55-0",{"v":13,"d":"13.00"},40.96,"˂1","N/A","http://www.selleckchem.com/products/vlx600.html","C17H15N7","Free Base","N/A","CC1=C2[NH]C3=NC(=NN=C3C2=CC=C1)N\\N=C(C)/C4=CC=CC=N4",3.589,5,2,3]
["S8947","SX-682","f8","L2600-12","in 10mM DMSO","CXCR","Immunology & Inflammation","SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.",{"v":467.2,"d":"467.20"},"1648843-04-2",{"v":93,"d":"93.00"},199.06,"˂1","N/A","http://www.selleckchem.com/products/sx-682.html","C19H14BF4N3O4S","Free Base","N/A","OB(O)C1=CC=C(OC(F)(F)F)C=C1CSC2=NC=C(C=N2)C(=O)NC3=CC=C(F)C=C3",5.761,4,1,8]
["S0407","XCT790","g8","L2600-12","in 10mM DMSO","Apoptosis related,Estrogen/progestogen Receptor","Endocrinology & Hormones","XCT-790 (Compound 12) is a potent and selective inverse agonist for estrogen-related receptor α (ERRα) with IC50 of 0.37 μM. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ. XCT-790 (Compound 12) significantly inhibits in vivo tumor growth and angiogenesis, and induces apoptosis.",596.42,"725247-18-7",{"v":8,"d":"8.00"},13.41,"<1","N/A","http://www.selleckchem.com/products/xct-790.html","C23H13F9N4O3S","free base","Compound 12","COC1=CC(=CC=C1OCC2=C(C=C(C=C2)C(F)(F)F)C(F)(F)F)\\C=C(C#N)\\C(=O)NC3=NN=C(S3)C(F)(F)F",6.179,5,1,10]
["S0707","Silmitasertib (CX-4945) sodium salt","h8","L2600-12","in 10mM DMSO","Casein Kinase","Metabolism","Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.",371.75,"1309357-15-0",{"v":74,"d":"74.00"},199.06,{"v":74,"d":"74.00"},199.06,"http://www.selleckchem.com/products/silmitasertib-sodium-salt.html","C19H11ClN3NaO2","sodium","CX-4945 sodium salt","[Na+].[O-]C(=O)C1=CC2=C(C=C1)C3=C(C=CN=C3)C(=N2)NC4=CC(=CC=C4)Cl",2.683,2,1,3]
["S0709","Tubastatin A TFA","a9","L2600-12","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.",449.42,"1239262-52-2",{"v":40,"d":"40.00"},{"v":89,"d":"89.00"},{"v":5,"d":"5.00"},11.13,"http://www.selleckchem.com/products/tubastatin-a-tfa.html","C22H22F3N3O4","trifluoroacetate","Tubastatin A trifluoroacetate salt","CN1CCC2=C(C1)C3=CC=CC=C3[N]2CC4=CC=C(C=C4)C(=O)NO.OC(=O)C(F)(F)F",{"v":0.93,"d":"0.930"},2,1,4]
["S0819","BL-918","b9","L2600-12","in 10mM DMSO","ULK","Autophagy","BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease treatment.",533.44,"2101517-69-3",{"v":100,"d":"100.00"},187.46,"<1","N/A","http://www.selleckchem.com/products/bl-918.html","C23H15F8N3OS","free base","N/A","FC1=CC(=C(NC(=O)C(NC(=S)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3=CC=CC=C3)C=C1)F",7.163,1,3,9]
["S2176","Tenovin-3","c9","L2600-12","in 10mM DMSO","p53,Sirtuin","DNA Damage/DNA Repair","Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.",327.44,"1011301-27-1",{"v":65,"d":"65.00"},198.51,"<1","N/A","http://www.selleckchem.com/products/tenovin-3.html","C18H21N3OS","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(N)C=C2",{"v":4.42,"d":"4.420"},1,3,5]
["S3224","Cinobufagin","d9","L2600-12","in 10mM DMSO","Akt,Apoptosis related,ATM/ATR,Bcl-2,Caspase,CDK,Chk,PI3K","Cell Cycle","Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT  and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.",442.54,"470-37-1",{"v":100,"d":"100.00"},225.97,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cinobufagin.html","C26H34O6","free base","Cinobufagine","CC(=O)OC1C2OC23C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C6=COC(=O)C=C6",2.593,5,1,3]
["S3241","Loureirin A","e9","L2600-12","in 10mM DMSO","Akt,PI3K","PI3K/Akt/mTOR","Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.",286.32,"119425-89-7",{"v":100,"d":"100.00"},349.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/loureirin-a.html","C17H18O4","free base","N/A","COC1=CC=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC",{"v":3.45,"d":"3.450"},3,1,6]
["S6760","LM22B-10","f9","L2600-12","in 10mM DMSO","Akt,ERK,Trk receptor","Protein Tyrosine Kinase","LM22B-10 is a small molecule TrkB/TrkC neurotrophin receptor co-activator, LM22B-10 selectively activates TrkB, TrkC, AKT and ERK in vivo and in vitro.",485.01,"342777-54-2",{"v":97,"d":"97.00"},{"v":200,"d":"200.00"},"<1","N/A","http://www.selleckchem.com/products/lm2b-10.html","C27H33ClN2O4","free base","N/A","OCCN(CCO)C1=CC=C(C=C1)C(C2=CC=C(Cl)C=C2)C3=CC=C(C=C3)N(CCO)CCO",3.919,0,4,13]
["S6811","Miransertib (ARQ-092)","g9","L2600-12","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Miransertib (ARQ-092) is a potent, selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.",432.52,"1313881-70-7",{"v":8,"d":"8.00"},{"v":18.5,"d":"18.50"},"<1","N/A","http://www.selleckchem.com/products/miransertib.html","C27H24N6","free base","N/A","NC1=C(C=CC=N1)C2=NC3=C(N=C(C=C3)C4=CC=CC=C4)[N]2C5=CC=C(C=C5)C6(N)CCC6",4.598,3,2,4]
["S6847","ML-9 HCl","h9","L2600-12","in 10mM DMSO","Akt,Autophagy,Calcium Channel,MLCK","PI3K/Akt/mTOR","ML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death.",361.29,"105637-50-1",{"v":72,"d":"72.00"},199.29,{"v":10,"d":"10.00"},27.68,"http://www.selleckchem.com/products/ml-9-hcl.html","C15H18Cl2N2O2S","hydrochloride","ML-9 hydrochloride","Cl.ClC1=CC=CC2=C1C=CC=C2[S](=O)(=O)N3CCCNCC3",2.385,2,1,2]
["S6851","RA-190","a10","L2600-12","in 10mM DMSO","Autophagy,p53,Proteasome","Ubiquitin","RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.",596.76,"1617495-03-0",{"v":100,"d":"100.00"},167.57,"<1","N/A","http://www.selleckchem.com/products/ra-190.html","C28H23Cl5N2O2","free base","N/A","Cl.NC(CC1=CC=CC=C1)C(=O)N2CC(=C/C3=CC(=C(Cl)C=C3)Cl)/C(=O)C(/C2)=C\\C4=CC(=C(Cl)C=C4)Cl",7.285,2,1,5]
["S6889","Monomethyl Fumarate","b10","L2600-12","in 10mM DMSO","Apoptosis related,Autophagy,GPR","GPCR & G Protein","Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.",{"v":130.1,"d":"130.10"},"2756-87-8",{"v":26,"d":"26.00"},199.85,{"v":20,"d":"20.00"},153.73,"http://www.selleckchem.com/products/monomethyl-fumarate.html","C5H6O4","free base","MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate","COC(=O)\\C=C\\C(O)=O",0.264,3,0,3]
["S7321","FIPI","c10","L2600-12","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.",421.47,"939055-18-2",{"v":45,"d":"45.00"},106.77,"<1","N/A","http://www.selleckchem.com/products/fipi.html","C23H24FN5O2","free base","5-Fluoro-2-indolyl deschlorohalopemide","FC1=CC2=C([NH]C(=C2)C(=O)NCCN3CCC(CC3)N4C(=O)NC5=C4C=CC=C5)C=C1",2.656,2,3,5]
["S8929","GCN2iB","d10","L2600-12","in 10mM DMSO","Serine/threonin kinase","Metabolism","GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.",451.83,"2183470-12-2",{"v":15,"d":"15.00"},{"v":33.2,"d":"33.20"},"<1","N/A","http://www.selleckchem.com/products/gcn2ib.html","C18H12ClF2N5O3S","free base","N/A","COC1=NC=C(Cl)C=C1[S](=O)(=O)NC2=C(F)C(=C(F)C=C2)C#CC3=CN=C(N)N=C3",2.869,6,2,6]
["S9611","ABTL-0812","e10","L2600-12","in 10mM DMSO","Akt,Autophagy,mTOR,ROS","PI3K/Akt/mTOR","ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.",296.44,"57818-44-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/abtl-0812.html","C18H32O3","free base","α-Hydroxylinoleic acid","CCCCC\\C=C/C\\C=C/CCCCCCC(O)C(O)=O",5.629,1,1,14]
["S9694","MLi-2","f10","L2600-12","in 10mM DMSO","LRRK2","Autophagy","MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM, and a radioligand competition binding assay with IC50 of 3.4 nM.",379.46,"1627091-47-7",{"v":76,"d":"76.00"},200.28,{"v":76,"d":"76.00"},200.28,"http://www.selleckchem.com/products/mli-2.html","C21H25N5O2","free base","N/A","CC1CN(CC(C)O1)C2=CC(=NC=N2)C3=N[NH]C4=CC=C(OC5(C)CC5)C=C34",3.892,5,1,4]
["E0441","NK-252","g10","L2600-12","in 10mM DMSO","Nrf2","Immunology & Inflammation","NK-252 is an activator of Nrf2  and interacts with the Nrf2-binding site of Keap1.",285.26,"1414963-82-8",{"v":57,"d":"57.00"},199.82,"<1","N/A","https://www.selleckchem.com/products/nk-252.html","C13H11N5O3","free base","N/A","O=C(NCC1=NC=CC=C1)NC2=NN=C(O2)C3=CC=CO3",{"v":0.83,"d":"0.830"},6,2,4]
["E1141","KI696","h10","L2600-12","in 10mM DMSO","NRF2","Immunology & Inflammation","KI696 is a potent and selective inhibitor of KEAP1/NRF2 interaction. KI696 induces the expression of each of the Nqo1, Ho-1, Txnrd1, Srxn1, Gsta3, Gclc genes in a dose-dependent manner.",550.63,"1799974-70-1",{"v":100,"d":"100.00"},181.61,"<1","N/A","https://www.selleckchem.com/products/ki696.html","C28H30N4O6S","free base","N/A","COC1=C2[N](C)N=NC2=CC(=C1)C(CC(O)=O)C3=CC(=C(C)C=C3)CN4CC(C)OC5=CC=CC=C5[S]4(=O)=O",4.395,7,0,7]
["E1220","CBR-470-1","a11","L2600-12","in 10mM DMSO","phosphoglycerate kinase","Metabolism","CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade.",{"v":365.9,"d":"365.90"},"2416095-06-0",{"v":73,"d":"73.00"},199.51,"<1","N/A","https://www.selleckchem.com/products/cbr-470-1.html","C14H20ClNO4S2","chlorosulfate","N/A","CC(C)CNC1C[S](=O)(=O)CC1[S](=O)(=O)C2=CC=C(Cl)C=C2",2.289,4,1,5]
["E1339","HPPE","b11","L2600-12","in 10mM DMSO","Nrf2","Immunology & Inflammation","HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.",479.48,"1325721-55-8",{"v":96,"d":"96.00"},200.22,"<1","N/A","https://www.selleckchem.com/products/hppe.html","C21H20F3N5O3S","free base","N/A","C[N]1C(=NC2=CC(=CC=C12)C(=O)NCCOCCO)NC3=NC4=CC=C(C=C4S3)C(F)(F)F",3.748,4,3,9]
["E2988","Sulfosuccinimidyl oleate sodium","c11","L2600-12","in 10mM DMSO","Mitophagy","Autophagy","Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain with IC50 of 4 μM. It inhibits CD36 mediated LCFA transport. It exhibits anti-inflammatory effect.",482.59,"1212012-37-7",{"v":23,"d":"23.00"},47.66,"<1","N/A","https://www.selleckchem.com/products/sulfosuccinimidyl-oleate-sodium.html","C22H37NO7S.Na","sodium","N/A","[Na;v0].CCCCCCCCC=CCCCCCCCC(=O)ON1C(=O)CC(C1=O)[S](O)(=O)=O",{"v":5.4,"d":"5.400"},4,0,18]
["E1318","Mavorixafor","d11","L2600-12","in 10mM DMSO","CXCR","GPCR & G Protein","Mavorixafor (AMD-070) is a potent, selective CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.",349.47,"558447-26-0",{"v":70,"d":"70.00"},{"v":200.3,"d":"200.30"},"<1","N/A","https://www.selleckchem.com/products/mavorixafor.html","C21H27N5","free base","AMD-070","NCCCCN(CC1=NC2=CC=CC=C2[NH]1)C3CCCC4=CC=CN=C34",3.196,2,2,7]
["E1537","MMRi62","e11","L2600-12","in 10mM DMSO","MDM2/MDMX","Apoptosis","MMRi62 is a ferroptosis inducer, targeting MDM2-MDM4 with Kd value of 1.39 μM. It exhibits a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy.",396.27,"352693-80-2",{"v":79,"d":"79.00"},199.36,"<1","N/A","https://www.selleckchem.com/products/mmri62.html","C21H15Cl2N3O","free base","N/A","OC1=C(C=CC2=C1N=CC=C2)C(NC3=CC=CC=N3)C4=C(Cl)C(=CC=C4)Cl",5.496,2,2,4]
["S4684","Sildenafil","f11","L2600-12","in 10mM DMSO","PDE","Metabolism","Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.",474.58,"139755-83-2","N/A",">10","N/A","N/A","http://selleckchem.com/products/sildenafil.html","C22H30N6O4S","free base","Revatio, UK-92480, Viagra","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4",2.247,6,1,7]
["S1037","Perifosine (KRX-0401)","a2","L2600-13","in 10mM Water","Akt","PI3K/Akt/mTOR","Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.",461.66,"157716-52-4","<1","N/A",{"v":8,"d":"8.00"},17.33,"http://selleckchem.com/products/Perifosine.html","C25H52NO4P","free base","NSC639966, D21266","CCCCCCCCCCCCCCCCCCO[P]([O-])(=O)OC1CC[N+](C)(C)CC1",4.607,2,0,20]
["S1135","Pemetrexed (LY-231514) disodium","b2","L2600-13","in 10mM Water","Apoptosis related,Autophagy,DHFR,DNA/RNA Synthesis,Thymidylate Synthase","Metabolism","Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.",471.37,"150399-23-8","<1","N/A",{"v":94,"d":"94.00"},199.42,"http://selleckchem.com/products/Pemetrexed-disodium.html","C20H19N5Na2O6","Disodium salt","LY-231514 disodium","[Na+].[Na+].NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N1",-1.804,3,4,9]
["S1149","Gemcitabine (LY-188011) HCl","c2","L2600-13","in 10mM Water","Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.",299.66,"122111-03-9","<1","N/A",{"v":19,"d":"19.00"},63.41,"http://selleckchem.com/products/Gemcitabine-Hydrochloride(Gemzar).html","C9H11F2N3O4.HCI","Hydrochloride","NSC 613327,LY-188011 HCl","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.012,3,3,2]
["S1494","Ralimetinib (LY2228820) dimesylate","d2","L2600-13","in 10mM Water","p38 MAPK","MAPK","Ralimetinib (LY2228820) dimesylate is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, does not alter p38 MAPK activation. Phase 1/2.",612.74,"862507-23-1",{"v":4,"d":"4.00"},6.53,{"v":100,"d":"100.00"},{"v":163.2,"d":"163.20"},"http://selleckchem.com/products/LY2228820.html","C24H29FN6.2CH4O3S","dimesylate","N/A","CC(C)(C)C[N]1C(=NC2=CC=C(N=C12)C3=C(N=C([NH]3)C(C)(C)C)C4=CC=C(F)C=C4)N.C[S;v6](O)(=O)=O",5.117,3,2,5]
["S1648","Cytarabine (U-19920A)","e2","L2600-13","in 10mM Water","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459,U-19920A) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.",243.22,"147-94-4",{"v":1,"d":"1.00"},4.11,{"v":48,"d":"48.00"},197.35,"http://selleckchem.com/products/Cytarabine(Cytosar-U).html","C9H13N3O5","free base","Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459,U-19920A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S1893","D-glutamine","f2","L2600-13","in 10mM Water","GluR","Neuronal Signaling","D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.",146.14,"5959-95-5","<1","N/A",{"v":9,"d":"9.00"},61.58,"http://selleckchem.com/products/D-glutamine.html","C5H10N2O3","free base","N/A","NC(CCC(N)=O)C(O)=O",-4.087,2,2,4]
["S1999","Sodium butyrate","g2","L2600-13","in 10mM Water","Apoptosis related,Autophagy,HDAC","Epigenetics","Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.",110.09,"156-54-7","<1","N/A",{"v":22,"d":"22.00"},199.84,"http://selleckchem.com/products/Sodium-butyrate.html","C4H7NaO2","Sodium Salt","NaB, Butanoic acid sodium salt","[Na+].CCCC([O-])=O",-0.556,0,0,2]
["S2008","Taurine","h2","L2600-13","in 10mM Water","Others","Others","Taurine is an organic acid widely distributed in animal tissues.",125.15,"107-35-7","<1","N/A",{"v":20,"d":"20.00"},159.81,"http://selleckchem.com/products/Taurine.html","C2H7NO3S","free base","N/A","NCC[S](O)(=O)=O",-1.243,0,1,2]
["S2420","Aloperine","a3","L2600-13","in 10mM Water","Antiviral,Bacterial","Microbiology","Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.",232.36,"56293-29-9",{"v":2,"d":"2.00"},8.61,{"v":12,"d":"12.00"},51.64,"http://selleckchem.com/products/aloperine.html","C15H24N2","Free Base","N/A","C1CCN2CC3CC(C=C4CCCNC34)C2C1",1.998,0,1,0]
["S2507","Salbutamol Sulfate","b3","L2600-13","in 10mM Water","Adrenergic Receptor","Neuronal Signaling","Salbutamol Sulfate (Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.",337.39,"51022-70-9","<1","N/A",{"v":68,"d":"68.00"},201.55,"http://selleckchem.com/products/Salbutamol-sulfate(Albuterol).html","C13H21NO3.H2SO4","Sulfate","Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent","CC(C)(C)NCC(O)C1=CC=C(O)C(=C1)CO.O[S](O)(=O)=O",0.334,0,4,5]
["S2879","AMD3465 hexahydrobromide","c3","L2600-13","in 10mM Water","CXCR","GPCR & G Protein","AMD3465 is a monomacrocyclic CXCR4 antagonist.",896.07,"185991-07-5, 185991-24-6 (free base)",{"v":2,"d":"2.00"},2.23,{"v":98,"d":"98.00"},109.37,"http://selleckchem.com/products/amd3465.html","C24H38N6.6HBr","HBr","N/A","Br.Br.Br.Br.Br.Br.C1CNCCNCCCN(CCNC1)CC2=CC=C(CNCC3=NC=CC=C3)C=C2",3.787,1,4,6]
["S3013","Plerixafor (AMD3100) 8HCl","d3","L2600-13","in 10mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.",794.47,"155148-31-5","<1","N/A",{"v":100,"d":"100.00"},125.87,"http://selleckchem.com/products/plerixafor-8hcl-db06809.html","C28H54N8.8HCl","Octahydrochloride","JM 3100 8HCl,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride","Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",2.536,0,6,4]
["S3056","Miltefosine","e3","L2600-13","in 10mM Water","Akt","PI3K/Akt/mTOR","Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.",407.57,"58066-85-6","<1","N/A",{"v":81,"d":"81.00"},198.74,"http://selleckchem.com/products/miltefosine-hexadecylphosphocholine.html","C21H46NO4P","free base","Hexadecylphosphocholine","CCCCCCCCCCCCCCCCO[P]([O-])(=O)OCC[N+](C)(C)C",3.722,2,0,20]
["S3753","L-Leucine","f3","L2600-13","in 10mM Water","mTOR","PI3K/Akt/mTOR","Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing.  L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.",131.17,"61-90-5","<1","N/A",{"v":5,"d":"5.00"},38.12,"http://selleckchem.com/products/l-leucine.html","C6H13NO2","free base","(S)-Leucine, Leu","CC(C)CC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4028","Dexamethasone Sodium Phosphate","g3","L2600-13","in 10mM Water","Autophagy,Complement System,COVID-19,COX,IL Receptor","Immunology & Inflammation","Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":516.4,"d":"516.40"},"55203-24-2","<1","N/A",{"v":103,"d":"103.00"},199.46,"http://selleckchem.com/products/dexamethasone-sodium-phosphate.html","C22H30FO8P.2Na","Disodium salt","Dexamethasone 21-phosphate disodium salt","[Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O",-0.541,3,1,4]
["S4029","Colistin Sulfate","h3","L2600-13","in 10mM Water","Bacterial","Microbiology","Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.",1400.63,"1264-72-8","<1","N/A",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"http://selleckchem.com/products/colistin-sulfate.html","C52H98N16O13.5/2H2SO4","Sulfate","Polymixin E Sulfate","CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O.CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC2CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC2=O)C(C)O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4157","Chloroquine diphosphate","a4","L2600-13","in 10mM Water","Anti-infection,ATM/ATR,Autophagy,COVID-19,TLR","PI3K/Akt/mTOR","Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).",515.86,"50-63-5","<1","N/A",{"v":100,"d":"100.00"},193.85,"http://selleckchem.com/products/chloroquine-phosphate.html","C18H26ClN3.2H3O4P","diphosphate","N/A","CCN(CC)CCCC(C)NC1=CC=NC2=C1C=CC(=C2)Cl.O[P](O)(O)=O.O[P](O)(O)=O",3.408,1,1,8]
["S4236","Proflavine Hemisulfate","b4","L2600-13","in 10mM Water","Anti-infection,DNA/RNA Synthesis","Microbiology","Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.",258.25,"1811-28-5","<1","N/A",{"v":22,"d":"22.00"},85.19,"http://selleckchem.com/products/proflavine-hemisulfate.html","C13H11N3.1/2H2SO4","Sulfate","N/A","NC1=CC=C2C=C3C=CC(=CC3=NC2=C1)N.NC4=CC=C5C=C6C=CC(=CC6=NC5=C4)N.O[S](O)(=O)=O",3.113,2,4,0]
["S4430","Hydroxychloroquine Sulfate (NSC 4375)","c4","L2600-13","in 10mM Water","Anti-infection,Autophagy,COVID-19,TLR","Autophagy","Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.",433.95,"747-36-4","<1","N/A",{"v":67,"d":"67.00"},{"v":154.4,"d":"154.40"},"http://selleckchem.com/products/hydroxychloroquine-sulfate.html","C18H28ClN3O5S","Sulfate","HCQ","CCN(CCO)CCCC(C)NC1=CC=NC2=CC(=CC=C12)Cl.O[S](O)(=O)=O",{"v":2.85,"d":"2.850"},1,2,9]
["S4741","Danshensu","d4","L2600-13","in 10mM Water","P450 (e.g. CYP17)","Metabolism","Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. Danshensu inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively.",198.17,"76822-21-4","<1","N/A",{"v":23,"d":"23.00"},116.06,"http://selleckchem.com/products/danshensu.html","C9H10O5","free base","Salvianic acid A","OC(CC1=CC=C(O)C(=C1)O)C(O)=O",0.679,1,3,3]
["S7306","Dorsomorphin (Compound C) 2HCl","e4","L2600-13","in 10mM Water","AMPK,Autophagy,TGF-beta/Smad","PI3K/Akt/mTOR","Dorsomorphin 2HCl (BML-275, Compound C) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line.",472.41,"1219168-18-9","<1","N/A",{"v":94,"d":"94.00"},198.98,"http://selleckchem.com/products/dorsomorphin-2hcl.html","C24H25N5O.2HCl","Dihydrochloride","BML-275 2HCl,Compound C 2HCl","Cl.Cl.C1CCN(CC1)CCOC2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC=C5",3.792,4,0,6]
["S7548","Rilmenidine Phosphate","f4","L2600-13","in 10mM Water","Imidazoline Receptor","GPCR & G Protein","Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used for the treatment of hypertension.",278.24,"85409-38-7",{"v":1,"d":"1.00"},3.59,{"v":55,"d":"55.00"},197.67,"http://selleckchem.com/products/rilmenidine-phosphate.html","C10H19N2O5P","Phosphate","N/A","O[P](O)(O)=O.C1CN=C(NC(C2CC2)C3CC3)O1",1.296,2,1,4]
["S7785","Pemetrexed Disodium Hydrate","g4","L2600-13","in 10mM Water","Apoptosis related,Autophagy,DHFR","Metabolism","Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.",516.42,"357166-30-4","<1","N/A",{"v":100,"d":"100.00"},193.64,"http://selleckchem.com/products/pemetrexed-disodium-hydrate.html","C20H21N5O6.5/2H2O.2Na","Disodium Hydrate","LY-231514 Disodium Hydrate","NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O[Na])C(=O)O[Na])N1",{"v":2.06,"d":"2.060"},7,4,11]
["S7873","Disodium (R)-2-Hydroxyglutarate","h4","L2600-13","in 10mM Water","ROS","Immunology & Inflammation","Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.",192.08,"103404-90-6","<1","N/A",{"v":38,"d":"38.00"},197.83,"http://selleckchem.com/products/disodium-r-2-hydroxyglutarate.html","C5H6Na2O5","disodium salt","D-α-Hydroxyglutaric acid disodium","OC(CCC(=O)O[Na])C(=O)O[Na]",-0.509,4,1,6]
["S8651","bpV (HOpic)","a5","L2600-13","in 10mM Water","PTEN","PI3K/Akt/mTOR","bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.",347.24,"722494-26-0","<1","N/A",{"v":69,"d":"69.00"},198.71,"http://selleckchem.com/products/bpv-hopic.html","C6H4NO8V.2K","potassium","Bisperoxovanadium (HOpic)","[K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O",-1.876,0,1,0]
["S4519","Citric acid trilithium salt tetrahydrate","b5","L2600-13","in 10mM Water","Others","Others","Citric acid trilithium salt tetrahydrate (Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids.",281.98,"6080-58-6","N/A","N/A",{"v":56,"d":"56.00"},{"v":198.6,"d":"198.60"},"http://selleckchem.com/products/citric-acid-trilithium-salt-tetrahydrate.html","C6H5Li3O7&bull;4H2O","free base","Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate","O.O.O.O.[Li]OC(=O)CC(O)(CC(=O)O[Li])C(=O)O[Li]",-1.875,6,0,8]
["S9665","Motixafortide (BL-8040)","c5","L2600-13","in 10mM Water","Apoptosis related,Bcl-2,CDK,CXCR,ERK,MicroRNA","Immunology & Inflammation","Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.",2159.52,"664334-36-5",{"v":-1,"d":"-1.00"},-0.46,{"v":100,"d":"100.00"},46.31,"http://www.selleckchem.com/products/motixafortide-bl-8040-.html","C97H144FN33O19S2","free base","BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140","NCCCCC1NC(=O)C(CCCNC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CSSCC(NC(=O)C(CCCNC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C4CCCN4C(=O)C(CCCCN)NC1=O)C(=O)NC(CCCNC(N)=N)C(N)=O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C7=CC=C(F)C=C7",-3.895,17,30,53]
["S2542","Phenformin (NSC-756501) HCl","d5","L2600-13","in 10mM Water","AMPK","PI3K/Akt/mTOR","Phenformin HCl (NSC-756501, Phenethylbiguanide) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.",241.72,"834-28-6","N/A","N/A","N/A",">10","http://selleckchem.com/products/Phenformin-hydrochloride.html","C10H15N5.HCl","Hydrochloride","Phenethylbiguanide HCl","Cl.NC(=N)NC(=N)NCCC1=CC=CC=C1",1.339,0,3,6]
["S1023","Erlotinib (OSI-774) HCl","a2","L2600-14","in 2mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781) HCl is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.",{"v":429.9,"d":"429.90"},"183319-69-9",{"v":4,"d":"4.00"},{"v":9.3,"d":"9.30"},"<1","N/A","http://selleckchem.com/products/Erlotinib-Hydrochloride.html","C22H23N3O4.HCl","Hydrochloride","CP358774, NSC 718781,OSI-774 HCl","Cl.COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.691,6,1,10]
["S1046","Vandetanib (ZD6474)","b2","L2600-14","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1118","XL147 analogue","c2","L2600-14","in 2mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2.",448.52,"956958-53-5",{"v":3,"d":"3.00"},6.69,"<1","N/A","http://selleckchem.com/products/XL147.html","C21H16N6O2S2","Free Base","SAR245408","CC1=CC=C(C=C1)[S](=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4",5.024,6,2,5]
["S1205","PIK-75 HCl","d2","L2600-14","in 2mM DMSO","DNA-PK,PI3K","PI3K/Akt/mTOR","PIK-75 HCl is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.",488.74,"372196-77-5",{"v":4,"d":"4.00"},8.18,"<1","N/A","http://selleckchem.com/products/PIK-75-Hydrochloride.html","C16H14BrN5O4S.HCl","Hydrochloride","N/A","Cl.CN(/N=C/C1=CN=C2C=CC(=C[N]12)Br)[S](=O)(=O)C3=C(C)C=CC(=C3)[N+]([O-])=O",3.272,4,0,5]
["S1211","Imiquimod (R-837)","e2","L2600-14","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Imiquimod (Aldara,R-837,S-26308) is a novel synthetic agent with immune response modifying activity.",{"v":240.3,"d":"240.30"},"99011-02-6",{"v":1,"d":"1.00"},4.16,"<1","N/A","http://selleckchem.com/products/Imiquimod.html","C14H16N4","free base","Aldara,R-837, S-26308","CC(C)C[N]1C=NC2=C(N)N=C3C=CC=CC3=C12",2.722,2,1,2]
["S1360","GSK1059615","f2","L2600-14","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Phase 1.",333.36,"958852-01-2",{"v":2,"d":"2.00"},{"v":6,"d":"6.00"},"<1","N/A","http://selleckchem.com/products/GSK1059615.html","C18H11N3O2S","Free Base","N/A","O=C1NC(=O)/C(S1)=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2",2.496,4,1,2]
["S1424","Prazosin HCl","g2","L2600-14","in 2mM DMSO","Adrenergic Receptor","GPCR & G Protein","Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.",419.86,"19237-84-4",{"v":4,"d":"4.00"},9.53,"<1","N/A","http://selleckchem.com/products/Prazosin-hydrochloride.html","C19H21N5O4.HCl","Hydrochloride","cp-12299-1","Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N",2.489,6,1,4]
["S1519","CCT129202","h2","L2600-14","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.",497.02,"942947-93-5",{"v":3,"d":"3.00"},6.04,"<1","N/A","http://selleckchem.com/products/CCT129202.html","C23H25ClN8OS","Free Base","N/A","CN(C)C1=CC=C(C=C1)C2=NC3=C(N4CCN(CC4)CC(=O)NC5=NC=CS5)C(=CN=C3[NH]2)Cl",2.898,4,2,6]
["S1837","Flubendazole","a3","L2600-14","in 2mM DMSO","Autophagy,Parasite","Autophagy","Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.",313.28,"31430-15-6",{"v":3,"d":"3.00"},9.58,"<1","N/A","http://selleckchem.com/products/flubendazole-flutelmium.html","C16H12FN3O3","free base","Flumoxanal, NSC 313680","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)C(=O)C3=CC=C(F)C=C3",{"v":3.26,"d":"3.260"},4,2,4]
["S2232","Ketanserin","b3","L2600-14","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Ketanserin (R41468, Ketanserinum) is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.",395.43,"74050-98-9",{"v":2,"d":"2.00"},5.06,"<1","N/A","http://selleckchem.com/products/Ketanserin-Vulketan-Gel.html","C22H22FN3O3","Free Base","R41468, Ketanserinum","FC1=CC=C(C=C1)C(=O)C2CCN(CC2)CCN3C(=O)NC4=CC=CC=C4C3=O",2.991,3,1,5]
["S2476","Itraconazole (R 51211)","c3","L2600-14","in 2mM DMSO","Autophagy,Fungal,Hedgehog/Smoothened,P450 (e.g. CYP17)","Stem Cells & Wnt","Itraconazole (R 51211) is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.",705.65,"84625-61-6",{"v":7,"d":"7.00"},9.92,"<1","N/A","http://selleckchem.com/products/Itraconazole(Sporanox).html","C35H38Cl2N8O4","free base","R 51211","CCC(C)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C[N]6C=NC=N6)(O5)C7=CC=C(Cl)C=C7Cl)C=C4",6.434,7,0,11]
["S2628","Gedatolisib (PKI-587)","d3","L2600-14","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.",615.73,"1197160-78-3",{"v":2,"d":"2.00"},3.25,"<1","N/A","http://selleckchem.com/products/pki587.html","C32H41N9O4","Free Base","PF-05212384","CN(C)C1CCN(CC1)C(=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C=C2",2.525,7,2,7]
["S2704","LY2109761","e3","L2600-14","in 2mM DMSO","Apoptosis related,Autophagy,TGF-beta/Smad","TGF-beta/Smad","LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.",441.52,"700874-71-1",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/ly2109761.html","C26H27N5O2","Free Base","N/A","C1C[N]2N=C(C3=NC=CC=C3)C(=C2C1)C4=CC=NC5=C4C=CC(=C5)OCCN6CCOCC6",{"v":3.62,"d":"3.620"},5,0,6]
["S2744","CCT137690","f3","L2600-14","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.",551.48,"1095382-05-0",{"v":4,"d":"4.00"},7.25,"<1","N/A","http://selleckchem.com/products/cct137690.html","C26H31BrN8O","Free Base","N/A","CN1CCN(CC1)C2=CC=C(C=C2)C3=NC4=C(N5CCN(CC5)CC6=NOC(=C6)C)C(=CN=C4[NH]3)Br",3.704,4,1,5]
["S2805","LY364947","g3","L2600-14","in 2mM DMSO","Casein Kinase,Mixed Lineage Kinase,RIP kinase,TGF-beta/Smad","TGF-beta/Smad","LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.",{"v":272.3,"d":"272.30"},"396129-53-6",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/ly364947.html","C17H12N4","Free Base","HTS 466284","[NH]1C=C(C2=C3C=CC=CC3=NC=C2)C(=N1)C4=NC=CC=C4",3.203,3,1,2]
["S2827","Torin 1","h3","L2600-14","in 2mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.",607.62,"1222998-36-8",{"v":2,"d":"2.00"},3.29,"<1","N/A","http://selleckchem.com/products/torin-1.html","C35H28F3N5O2","Free Base","N/A","CCC(=O)N1CCN(CC1)C2=CC=C(C=C2C(F)(F)F)N3C(=O)C=CC4=C3C5=CC(=CC=C5N=C4)C6=CC7=CC=CC=C7N=C6",5.914,4,0,5]
["S2893","NU7026","a4","L2600-14","in 2mM DMSO","Apoptosis related,DNA-PK,PI3K","DNA Damage/DNA Repair","NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.",281.31,"154447-35-5",{"v":1,"d":"1.00"},3.55,"<1","N/A","http://selleckchem.com/products/nu7026.html","C17H15NO3","Free Base","LY293646","O=C1C=C(OC2=C1C=CC3=C2C=CC=C3)N4CCOCC4",2.732,3,0,1]
["S3042","Purmorphamine","b4","L2600-14","in 2mM DMSO","Autophagy,Hedgehog/Smoothened","Stem Cells & Wnt","Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.",520.62,"483367-10-8",{"v":4,"d":"4.00"},7.68,"<1","N/A","http://selleckchem.com/products/purmorphamine.html","C31H32N6O2","Free Base","Shh Signaling Antagonist VI","C1CCC(CC1)[N]2C=NC3=C2N=C(OC4=C5C=CC=CC5=CC=C4)N=C3NC6=CC=C(C=C6)N7CCOCC7",6.758,5,1,6]
["S3064","Ambroxol HCl","c4","L2600-14","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.",414.56,"23828-92-4",{"v":4,"d":"4.00"},9.65,"<1","N/A","http://selleckchem.com/products/ambroxol-hcl.html","C13H18Br2N2O.HCl","Hydrochloride","N/A","Cl.NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",3.121,0,3,3]
["S3770","Sodium Aescinate","d4","L2600-14","in 2mM DMSO","NF-κB","NF-κB","Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.  Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.",1123.21,"20977-05-3",{"v":10,"d":"10.00"},{"v":8.9,"d":"8.90"},"N/A","N/A","http://selleckchem.com/products/sodium-aescinate.html","C54H83NaO23","sodium salt","Escin sodium salt","CC(OC(C)=O)C(C)C(=O)OCC12C(O)C3OC1CC4(C)C(=CCC5C6(C)CCC(OC7OC(C(OC8OC(CO)C(O)C(O)C8O)C(O)C7OC9OCC(O)C(O)C9O)C(=O)O[Na])C(C)(CO)C6CCC45C)C2CC3(C)C",-0.485,13,10,17]
["S7035","XL388","e4","L2600-14","in 2mM DMSO","mTOR","PI3K/Akt/mTOR","XL388 is a highly potent, selective, ATP-competitive inhibitor of  mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.",{"v":455.5,"d":"455.50"},"1251156-08-7",1.25,2.74,"<1","N/A","http://selleckchem.com/products/xl388.html","C23H22FN3O4S","free base","N/A","CC1=C(F)C(=CC=C1C(=O)N2CCOC3=CC=C(C=C3C2)C4=CN=C(N)C=C4)[S](C)(=O)=O",3.007,5,1,3]
["S7105","BAM7","f4","L2600-14","in 2mM DMSO","Bcl-2","Apoptosis","BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.",405.47,"331244-89-4",{"v":2,"d":"2.00"},4.93,"<1","N/A","http://selleckchem.com/products/bam7.html","C21H19N5O2S","Free Base","N/A","CCOC1=CC=CC=C1N\\N=C2/C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C",{"v":4.1,"d":"4.100"},5,1,6]
["S7164","GSK343","g4","L2600-14","in 2mM DMSO","Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. GSK343 induces autophagy.",541.69,"1346704-33-3",{"v":2,"d":"2.00"},3.69,"<1","N/A","http://www.selleck.cn/products/gsk343.html","C31H39N7O2","Free Base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC(=NC=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.902,4,2,8]
["S7400","ISRIB (trans-isomer)","h4","L2600-14","in 2mM DMSO","PERK","Apoptosis","ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.",451.34,"1597403-47-8",{"v":4,"d":"4.00"},8.86,"<1","N/A","http://selleckchem.com/products/isrib-trans-isomer.html","C22H24Cl2N2O4","Free Base","N/A","ClC1=CC=C(OCC(=O)NC2CCC(CC2)NC(=O)COC3=CC=C(Cl)C=C3)C=C1",4.055,4,2,8]
["S7756","Indoximod (NLG-8189）","a5","L2600-14","in 2mM DMSO","IDO/TDO","Metabolism","Indoximod (NLG-8189, 1-Methyl-D-tryptophan, 1-MT), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!",218.25,"110117-83-4",{"v":1,"d":"1.00"},4.58,"<1","N/A","http://selleckchem.com/products/indoximod-nlg-8189.html","C12H14N2O2","Free Base","1-Methyl-D-tryptophan, 1-MT","C[N]1C=C(CC(N)C(O)=O)C2=CC=CC=C12",-1.106,1,1,3]
["S7840","Dorsomorphin (Compound C)","b5","L2600-14","in 2mM DMSO","AMPK,Autophagy,TGF-beta/Smad","PI3K/Akt/mTOR","Dorsomorphin (Compound C, BML-275) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble <a target='_blank' href='https://www.selleckchem.com/products/dorsomorphin-2hcl.html'>S7306 Dorsomorphin (Compound C) 2HCl</a> is recommended.",399.49,"866405-64-3",{"v":1,"d":"1.00"},{"v":2.5,"d":"2.50"},"<1","N/A","http://selleckchem.com/products/dorsomorphin.html","C24H25N5O","Free Base","BML-275,Compound C","C1CCN(CC1)CCOC2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC=C5",3.028,4,0,6]
["S7842","LY3009120","c5","L2600-14","in 2mM DMSO","Autophagy,Raf","MAPK","LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. LY03009120 induces autophagy. Phase 1.",424.51,"1454682-72-4",{"v":3,"d":"3.00"},7.07,"<1","N/A","http://selleckchem.com/products/ly3009120.html","C23H29FN6O","Free Base","DP-4978","CNC1=NC=C2C=C(C(=NC2=N1)C)C3=CC(=C(F)C=C3C)NC(=O)NCCC(C)(C)C",4.158,4,3,6]
["S8527","ROC-325","d5","L2600-14","in 2mM DMSO","Autophagy","Autophagy","ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.",503.06,"1859141-26-6",{"v":4,"d":"4.00"},7.95,"<1","N/A","http://selleckchem.com/products/roc-325.html","C28H27ClN4OS","free base","N/A","CN(CCNC1=CC=NC2=C1C=CC(=C2)Cl)CCNC3=CC=C(C)C4=C3C(=O)C5=CC=CC=C5S4",6.264,2,2,8]
["S8274","STO-609","e5","L2600-14","in 2mM DMSO","AMPK,Autophagy,CaMK","Neuronal Signaling","STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 inhibits AMPKK activity and inhibits autophagy.",314.29,"52029-86-4","N/A",{"v":2,"d":"2.00"},"N/A","N/A","http://selleckchem.com/products/sto-609.html","C19H10N2O3","free base","N/A","OC(=O)C1=CC=C2C3=NC4=C(C=CC=C4)[N]3C(=O)C5=C2C1=CC=C5",3.633,3,0,1]
["E1345","HS148","f5","L2600-14","in 2mM DMSO","DAPK","Apoptosis","HS148 (DAPK3 inhibitor HS148) is a selective inhibitor of DAPK3 with Ki of 119 nM",347.37,"1892595-16-2",{"v":2,"d":"2.00"},5.76,"<1","N/A","https://www.selleckchem.com/products/hs148.html","C15H14FN5O2S","Free Base","DAPK3 inhibitor HS148","CCC(SC1=NC(=O)C2=C(N1)[N](N=C2)C3=CC(=CC=C3)F)C(N)=O",2.449,4,2,5]
["S1346","Heparin sodium","a2","L2600-15","in 2mM Water","Autophagy,Factor Xa,Thrombin","Proteases","Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.","6000-20000","9041-08-1","<1","N/A",{"v":100,"d":"100.00"},{"v":8,"d":"8.00"},"http://selleckchem.com/products/Heparin-sodium.html","(C12H16NS2Na3)20","Sodium salt","N/A","CCC1CC(N[R])C(OC1CO[S]([O-])(=O)=O)OC2C(O)C(O)C(OC3C(CO[R])OC(OC4C(O)C(O[S]([O-])(=O)=O)C(OC5C(O)C(N[S]([O-])(=O)=O)C(C)OC5CO[S]([O-])(=O)=O)OC4C([O-])=O)C(N[S]([O-])(=O)=O)C3[S]([O-])(=O)=O)OC2C([O-])=O",-22.565,13,7,27]
["S8030","Plerixafor (AMD3100)","b2","L2600-15","in 2mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.",502.78,"110078-46-1","<1","N/A",{"v":3,"d":"3.00"},5.97,"http://selleckchem.com/products/plerixafor.html","C28H54N8","Free Base","JM 3100, SID791","C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",{"v":-0.52,"d":"-0.520"},0,6,4]