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[{"$nulls":3},"CNS-Penetrant Compound Library  (96-well)-L4700"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 808 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"In 10 mM DMSO : Plate layout L4700-01~10;    In 2 mM DMSO : Plate layout L4700-12"]
[{"$nulls":3},"In 10 mM Water: Plate layout L4700-11;      In 2 mM Water  : Plate layout L4700-13"]
[]
[]
[null,"Plate layout: L4700-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1004","S1035","S1078","S1153","S1210","S1243","S1302","S1336","S1364","S1398","Empty"]
[{"$nulls":3},"Veliparib (ABT-888)","Pazopanib HCl (GW786034 HCl)","MK-2206 2HCl","Roscovitine (CYC202)","Methotrexate (CL-14377)","Agomelatine (S20098)","Ifosfamide (NSC109724)","Fluvoxamine (DU-23000) maleate","Patupilone (Epothilone B)","Stavudine (d4T)"]
[null,"b","Empty","S1008","S1039","S1082","S1156","S1212","S1245","S1305","S1340","S1380","S1401","Empty"]
[{"$nulls":3},"Selumetinib (AZD6244)","Rapamycin (AY-22989)","Vismodegib (GDC-0449)","Capecitabine (RO 09-1978)","Bendamustine (SDX105) HCl","Latrepirdine 2HCl","Mercaptopurine (6-MP)","Gatifloxacin","Lopinavir (ABT-378)","Tenofovir"]
[null,"c","Empty","S1017","S1040","S1087","S1163","S1223","S1251","S1322","S1342","S1385","S1405","Empty"]
[{"$nulls":3},"Cediranib (AZD2171)","Sorafenib (BAY 43-9006) tosylate","Iniparib (BSI-201)","Onalespib (AT13387)","Epirubicin (IMI 28) HCl","Dienogest","Dexamethasone (MK-125)","Genistein (NPI 031L)","Mosapride Citrate","Vecuronium Bromide"]
[null,"d","Empty","S1021","S1047","S1101","S1185","S1230","S1255","S1326","S1343","S1390","S1430","Empty"]
[{"$nulls":3},"Dasatinib (BMS-354825)","Vorinostat (SAHA)","Vatalanib (PTK787) 2HCl","Ritonavir (ABT-538)","Flavopiridol (L86-8275)","Nepafenac","Edaravone","Ginkgolide B","Ondansetron HCl","Rolipram (ZK-62711)"]
[null,"e","Empty","S1025","S1053","S1106","S1189","S1231","S1256","S1328","S1351","S1391","S1432","Empty"]
[{"$nulls":3},"Gefitinib (ZD1839)","Entinostat (MS-275)","OSU-03012 (AR-12)","Aprepitant (MK-0869)","Topotecan (NSC609699) HCl","Rufinamide","Etodolac","Ivermectin (MK-933)","Oxcarbazepine","Sumatriptan Succinate"]
[null,"f","Empty","S1026","S1055","S1120","S1193","S1237","S1259","S1330","S1356","S1394","S1437","Empty"]
[{"$nulls":3},"Imatinib (STI571) Mesylate","Enzastaurin (LY317615)","Everolimus (RAD001)","Thalidomide (K17)","Temozolomide (CCRG 81045)","Ramelteon","Felbamate","Levetiracetam (UCB-L059)","Pizotifen Malate","Tizanidine HCl"]
[null,"g","Empty","S1028","S1057","S1144","S1199","S1238","S1261","S1331","S1357","S1396","S1438","Empty"]
[{"$nulls":3},"Lapatinib (GW-572016) Ditosylate","Obatoclax Mesylate (GX15-070)","Ivacaftor (VX-770)","Cladribine (RWJ 26251)","Tamoxifen (ICI 46474)","Celecoxib (SC 58635)","Fluconazole (UK 49858)","Lidocaine","Resveratrol (SRT501)","Topiramate"]
[null,"h","Empty","S1029","S1060","S1145","S1204","S1241","S1283","S1333","S1358","S1397","S1441","Empty"]
[{"$nulls":3},"Lenalidomide (CC-5013)","Olaparib (AZD2281)","SNS-032 (BMS-387032)","Melatonin (NSC 113928)","Vincristine (NSC-67574) sulfate","Asenapine maleate","Fluoxetine (Lilly 110140) HCl","Loratadine (SCH29851)","Rocuronium Bromide","Venlafaxine HCl"]
[]
[]
[]
[null,"Plate layout: L4700-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1442","S1497","S1622","S1653","S1693","S1725","S1761","S1832","S1885","S1915","Empty"]
[{"$nulls":3},"Voriconazole (UK-109496)","Pralatrexate (NSC 754230)","Prednisone (NSC-10023)","Tretinoin (NSC 122758)","Carbamazepine","Terbinafine","Suprofen","Atracurium Besylate","Felodipine","Sulfamethoxazole"]
[null,"b","Empty","S1444","S1505","S1626","S1654","S1702","S1733","S1762","S1840","S1896","S1920","Empty"]
[{"$nulls":3},"Ziprasidone HCl","Aztreonam","Naproxen Sodium","Phenylbutazone","Didanosine","Methylprednisolone (NSC-19987)","Pyrazinamide","Lomustine","Hydroxyurea (NSC-32065)","Haloperidol"]
[null,"c","Empty","S1445","S1567","S1638","S1662","S1704","S1734","S1764","S1845","S1898","S1937","Empty"]
[{"$nulls":3},"Zonisamide","Pomalidomide (CC-4047)","Ibuprofen (NSC 256857)","Isradipine","Emtricitabine (BW 1592)","Meloxicam","Rifampin (NSC-113926)","Cimetidine","Tropisetron HCl","Isoniazid"]
[null,"d","Empty","S1457","S1576","S1639","S1666","S1705","S1736","S1777","S1849","S1902","S1940","Empty"]
[{"$nulls":3},"Atazanavir (BMS-232632) Sulfate","Sulfasalazine (NSC 667219)","Amprenavir (VX-478)","Flucytosine","Progesterone (NSC 9704)","Methocarbamol","Ethionamide","Daidzein","Vitamin B12","Levofloxacin"]
[null,"e","Empty","S1458","S1578","S1645","S1679","S1706","S1737","S1789","S1859","S1903","S1950","Empty"]
[{"$nulls":3},"Neflamapimod (VX-745)","Candesartan (CV-11974)","Ketoprofen","Flurbiprofen","Lamivudine (BCH-189)","Prednisolone (NSC-9900)","Tetrabenazine (Xenazine)","Diethylstilbestrol","Diclofenac Sodium","Metformin HCl"]
[null,"f","Empty","S1483","S1607","S1646","S1680","S1713","S1742","S1792","S1866","S1907","S1956","Empty"]
[{"$nulls":3},"Iloperidone","Rizatriptan Benzoate","Ketorolac","Disulfiram (NSC 190940)","Piroxicam","Nevirapine (NSC 641530)","Simvastatin (MK 733)","Diphenhydramine HCl","Metronidazole","Miconazole Nitrate"]
[null,"g","Empty","S1486","S1608","S1647","S1683","S1716","S1747","S1805","S1869","S1913","S1959","Empty"]
[{"$nulls":3},"AEE788 (NVP-AEE788)","Pyridostigmine Bromide","Adenosine","Ipratropium Bromide","Glyburide (Glibenclamide)","Nimodipine","Acetylcholine Chloride","Dapoxetine HCl","Tropicamide","Tolfenamic Acid"]
[null,"h","Empty","S1488","S1614","S1649","S1692","S1723","S1754","S1807","S1878","S1914","S1960","Empty"]
[{"$nulls":3},"Naratriptan HCl","Riluzole (PK 26124)","Zolmitriptan","Busulfan (NSC-750)","Indomethacin (NSC-77541)","Oxybutynin","Aciclovir (BW 248U)","Ganciclovir (BW 759)","Pregnenolone","Pranoprofen"]
[]
[]
[]
[null,"Plate layout: L4700-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1965","S2024","S2061","S2108","S2167","S2300","S2451","S2466","S2531","S2577","Empty"]
[{"$nulls":3},"Primidone","Ketotifen Fumarate","Lovastatin (MK-803)","Flunixin Meglumin","Bazedoxifene (TSE-424) acetate","Ferulic Acid","Amantadine HCl","Estriol","Asaraldehyde","Phenacetin"]
[null,"b","Empty","S1972","S2025","S2077","S2111","S2170","S2310","S2452","S2471","S2541","S2579","Empty"]
[{"$nulls":3},"Tamoxifen (ICI 46474) Citrate","Urapidil HCl","Atorvastatin Calcium","Lapatinib (GW-572016)","Givinostat (ITF2357)","Honokiol (NSC 293100)","Amfebutamone (Bupropion) HCl","Gallamine Triethiodide","Clomipramine HCl","Zidovudine"]
[null,"c","Empty","S1975","S2037","S2082","S2113","S2217","S2346","S2454","S2493","S2547","S2586","Empty"]
[{"$nulls":3},"Aripiprazole","Candesartan Cilexetil","Adiphenine HCl","Cisatracurium Besylate","Irinotecan (CPT-11) HCl Trihydrate","Puerarin","Bupivacaine HCl","Olanzapine","Tiotropium Bromide hydrate","Dimethyl Fumarate"]
[null,"d","Empty","S1978","S2040","S2084","S2116","S2220","S2349","S2455","S2497","S2549","S2602","Empty"]
[{"$nulls":3},"Methscopolamine","Nimesulide","Duloxetine HCl","Conivaptan HCl","SB590885","Rutaecarpine","Bethanechol chloride","Pancuronium dibromide","Trospium chloride","Acemetacin"]
[null,"e","Empty","S2006","S2041","S2087","S2119","S2222","S2350","S2458","S2504","S2553","S2614","Empty"]
[{"$nulls":3},"Pyrimethamine","Dyclonine HCl","Rivastigmine Tartrate","Probucol","PF-3716556","Rutin","Clonidine HCl","Ribavirin (ICN-1229)","5-Aminolevulinic acid HCl","Arecoline HBr"]
[null,"f","Empty","S2007","S2043","S2090","S2128","S2247","S2351","S2459","S2508","S2556","S2621","Empty"]
[{"$nulls":3},"Sulindac","Memantine HCl","Dexmedetomidine HCl","Bazedoxifene (WAY-140424) HCl","Buparlisib (BKM120)","Salicin","Clozapine","Scopolamine (LSM-4015) HBr","Rosiglitazone (BRL 49653)","AZD5438"]
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[]
[]
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[]
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[]
[]
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[]
[]
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[{"$nulls":3},"Granisetron HCl","D-Cycloserine","Ceftazidime","Tolmetin Sodium","Homotaurine","L-Aspartic aicd (sodium)"]
[null,"e","Empty","S1440","S2133","S3662","S4575","S5631","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Varenicline Tartrate (CP 526555-18)","Gabapentin","Pirenzepine dihydrochloride","Pralidoxime chloride","L-Alanine"]
[null,"f","Empty","S1518","S2462","S3748","S4700","S5632","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ibuprofen Lysine","Donepezil HCl","Acamprosate Calcium","4-Aminobutyric acid (GABA)","L-aspartic Acid"]
[null,"g","Empty","S1579","S2490","S3852","S4703","S6141","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Palbociclib (PD0332991) Isethionate","Neostigmine Bromide","L-Theanine","Choline bitartrate","Anserine"]
[null,"h","Empty","S1648","S2572","S4027","S4740","S7785","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Cytarabine (U-19920A)","Streptomycin sulfate","Flavoxate HCl","Sodium ferulate","Pemetrexed Disodium Hydrate"]
[]
[]
[]
[null,"Plate layout: L4700-12"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1023","S1929","S3041","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Erlotinib (OSI-774) HCl","Irsogladine","Droxidopa"]
[null,"b","Empty","S1043","S2047","S3821","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Tandutinib (MLN518)","Lornoxicam","Nuciferine"]
[null,"c","Empty","S1046","S2110","S4218","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)","Vinpocetine","Amoxapine"]
[null,"d","Empty","S1371","S2232","S5232","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Cefoselis Sulfate","Ketanserin","Alectinib (CH5424802) hydrochloride"]
[null,"e","Empty","S1463","S2251","S5499","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ofloxacin","(-)-Huperzine A (HupA)","Amantadine"]
[null,"f","Empty","S1615","S2476","S8724","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Risperidone","Itraconazole (R 51211)","Lazertinib"]
[null,"g","Empty","S1642","S2582","S3304","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Methyldopa","Trazodone HCl","Stylopine"]
[null,"h","Empty","S1724","S2893","S9464","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Paliperidone","NU7026","Tranylcypromine Sulfate"]
[]
[]
[]
[null,"Plate layout: L4700-13"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2106","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Azasetron HCl"]
[null,"b","Empty","S4226","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Minocycline (CL 59806) HCl"]
[null,"c","Empty","S4694","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Alosetron Hydrochloride"]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L4700-CNS-Penetrant-808 cpds","index":1,"n_rows":809,"n_cols":23,"rows_kept":809}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1004","Veliparib (ABT-888)","a2","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,PARP","DNA Damage/DNA Repair","Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.",244.29,"912444-00-9",{"v":17,"d":"17.00"},69.59,"<1",null,"http://selleckchem.com/products/ABT-888.html","C13H16N4O","free base","NSC 737664","CC1(CCCN1)C2=NC3=C(C=CC=C3[NH]2)C(N)=O",0.986,2,3,2]
["S1008","Selumetinib (AZD6244)","b2","L4700-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It  also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.",457.68,"606143-52-6",{"v":91,"d":"91.00"},198.83,"<1",null,"http://selleckchem.com/products/AZD6244.html","C17H15BrClFN4O3","free base","ARRY-142886","C[N]1C=NC2=C(F)C(=C(C=C12)C(=O)NOCCO)NC3=CC=C(Br)C=C3Cl",3.234,3,3,6]
["S1017","Cediranib (AZD2171)","c2","L4700-01","in 10mM DMSO","Autophagy,c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.",450.51,"288383-20-0",{"v":90,"d":"90.00"},199.77,"<1",null,"http://selleckchem.com/products/Cediranib.html","C25H27FN4O3","free base","NSC-732208","COC1=C(OCCCN2CCCC2)C=C3N=CN=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.761,5,1,8]
["S1021","Dasatinib (BMS-354825)","d2","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.",488.01,"302962-49-8",{"v":98,"d":"98.00"},200.82,"<1",null,"http://selleckchem.com/products/Dasatinib.html","C22H26ClN7O2S","free base","BMS-354825","CC1=NC(=CC(=N1)N2CCN(CCO)CC2)NC3=NC=C(S3)C(=O)NC4=C(Cl)C=CC=C4C",3.439,4,3,7]
["S1025","Gefitinib (ZD1839)","e2","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,EGFR","Protein Tyrosine Kinase","Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.",{"v":446.9,"d":"446.90"},"184475-35-2",{"v":89,"d":"89.00"},199.15,"<1",null,"http://selleckchem.com/products/Gefitinib.html","C22H24ClFN4O3","free base","Iressa,ZD1839","COC1=C(OCCCN2CCOCC2)C=C3C(=NC=NC3=C1)NC4=CC=C(F)C(=C4)Cl",4.203,5,1,8]
["S1026","Imatinib (STI571) Mesylate","f2","L4700-01","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.",589.71,"220127-57-1",{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Imatinib-Mesylate.html","C29H31N7O.CH4SO3","Mesylate","Gleevec, Glivec, CGP-57148B,STI571","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5.C[S](O)(=O)=O",3.806,4,2,7]
["S1028","Lapatinib (GW-572016) Ditosylate","g2","L4700-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.",925.46,"388082-77-7",{"v":100,"d":"100.00"},108.05,"<1",null,"http://selleckchem.com/products/Lapatinib-Ditosylate.html","C29H26ClFN4O4S.2C7H8O3S","Ditosylat","GW-572016","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(=C7)F)C(=C6)Cl)C5=C4",9.339,6,2,13]
["S1029","Lenalidomide (CC-5013)","h2","L4700-01","in 10mM DMSO","Apoptosis related,Caspase,E3 Ligase ,E3 ligase Ligand,TNF-alpha,VEGFR","Ubiquitin","Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.",259.26,"191732-72-6",{"v":52,"d":"52.00"},200.57,"<1",null,"https://www.selleckchem.com/products/lenalidomide-s1029.html","C13H13N3O3","free base","CC-5013","NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",-0.515,3,2,1]
["S1035","Pazopanib HCl (GW786034 HCl)","a3","L4700-01","in 10mM DMSO","Autophagy,c-Kit,CSF-1R,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.",473.98,"635702-64-6",{"v":17,"d":"17.00"},35.87,"<1",null,"http://selleckchem.com/products/Pazopanib-Hydrochloride.html","C21H23N7O2S.HCl","Hydrochloride","GW786034 HCl","Cl.C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",4.123,5,2,5]
["S1039","Rapamycin (AY-22989)","b3","L4700-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1",null,"http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1040","Sorafenib (BAY 43-9006) tosylate","c3","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate)  is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",637.03,"475207-59-1",{"v":127,"d":"127.00"},199.36,0.01,0.02,"http://selleckchem.com/products/Sorafenib-Tosylate.html","C21H16ClF3N4O3.C7H8O3S","Tosylate","BAY 43-9006 tosylate,NSC-724772 tosylate","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O",5.824,4,3,7]
["S1047","Vorinostat (SAHA)","d3","L4700-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1",null,"http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1053","Entinostat (MS-275)","e3","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.",376.41,"209783-80-2",{"v":75,"d":"75.00"},199.25,"<1",null,"http://selleckchem.com/products/MS-275.html","C21H20N4O3","free base","SNDX-275","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC(=O)OCC3=CN=CC=C3)C=C2",2.071,4,3,7]
["S1055","Enzastaurin (LY317615)","f3","L4700-01","in 10mM DMSO","PKC","TGF-beta/Smad","Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.",515.61,"170364-57-5",{"v":30,"d":"30.00"},58.18,"<1",null,"http://selleckchem.com/products/Enzastaurin.html","C32H29N5O2","free base","N/A","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](C5CCN(CC5)CC6=NC=CC=C6)C7=CC=CC=C47",{"v":4.32,"d":"4.320"},3,1,5]
["S1057","Obatoclax Mesylate (GX15-070)","g3","L4700-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1",null,"http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","h3","L4700-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,null,null,"http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1078","MK-2206 2HCl","a4","L4700-01","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.",480.39,"1032350-13-2",{"v":14,"d":"14.00"},29.14,"<1",null,"http://selleckchem.com/products/MK-2206.html","C25H21N5O.2HCl","Dihydrochloride","N/A","Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6",4.183,3,2,3]
["S1082","Vismodegib (GDC-0449)","b4","L4700-01","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.",{"v":421.3,"d":"421.30"},"879085-55-9",{"v":84,"d":"84.00"},199.38,"<1",null,"http://selleckchem.com/products/GDC-0449.html","C19H14Cl2N2O3S","free base","GDC-0449","C[S](=O)(=O)C1=CC=C(C(=C1)Cl)C(=O)NC2=CC(=C(Cl)C=C2)C3=NC=CC=C3",4.265,4,1,4]
["S1087","Iniparib (BSI-201)","c4","L4700-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Iniparib (BSI-201, NSC-746045, IND-71677) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.",292.03,"160003-66-7",{"v":58,"d":"58.00"},198.61,"<1",null,"http://selleckchem.com/products/BSI-201.html","C7H5IN2O3","free base","NSC-746045, IND-71677","NC(=O)C1=CC(=C(I)C=C1)[N+]([O-])=O",1.304,1,1,2]
["S1101","Vatalanib (PTK787) 2HCl","d4","L4700-01","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Vatalanib 2HCl (PTK787, ZK 222584, cpg-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM in a cell-free assay, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 3.",419.73,"212141-51-0",{"v":85,"d":"85.00"},202.51,{"v":10,"d":"10.00"},23.82,"http://selleckchem.com/products/Vatalanib,Dihydrochloride-Salt.html","C20H15ClN4.2HCl","Dihydrochloride","ZK 222584 (cpg-79787) 2HCl","Cl.Cl.ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C24)C=C1",5.469,3,1,4]
["S1106","OSU-03012 (AR-12)","e4","L4700-01","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.",460.45,"742112-33-0",{"v":11,"d":"11.00"},23.89,"<1",null,"http://selleckchem.com/products/OSU-03012.html","C26H19F3N4O","free base","N/A","NCC(=O)NC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC4=C(C=C3)C5=C(C=CC=C5)C=C4)C(F)(F)F",5.212,2,2,5]
["S1120","Everolimus (RAD001)","f4","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1",null,"http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1144","Ivacaftor (VX-770)","g4","L4700-01","in 10mM DMSO","CFTR","Transmembrane Transporters","Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.",392.49,"873054-44-5",{"v":78,"d":"78.00"},198.73,"<1",null,"http://selleckchem.com/products/VX-770.html","C24H28N2O3","free base","VX-770","CC(C)(C)C1=CC(=C(NC(=O)C2=CNC3=C(C=CC=C3)C2=O)C=C1O)C(C)(C)C",4.516,2,3,4]
["S1145","SNS-032 (BMS-387032)","h4","L4700-01","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.",380.53,"345627-80-7",{"v":76,"d":"76.00"},199.72,"<1",null,"http://selleckchem.com/products/SNS-032.html","C17H24N4O2S2","free base","N/A","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1",{"v":2.07,"d":"2.070"},4,2,6]
["S1153","Roscovitine (CYC202)","a5","L4700-01","in 10mM DMSO","CDK","Cell Cycle","Roscovitine (CYC202, Seliciclib, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6. Phase 2.",354.45,"186692-46-6",{"v":71,"d":"71.00"},200.31,"<1",null,"http://selleckchem.com/products/Roscovitine.html","C19H26N6O","free base","Seliciclib, R-roscovitine","CCC(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=CC=C3",{"v":3.32,"d":"3.320"},3,3,8]
["S1156","Capecitabine (RO 09-1978)","b5","L4700-01","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis","DNA Damage/DNA Repair","Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.",359.35,"154361-50-9",{"v":72,"d":"72.00"},200.36,{"v":6,"d":"6.00"},{"v":16.7,"d":"16.70"},"http://selleckchem.com/products/Capecitabine(Xeloda).html","C15H22FN3O6","free base","RO 09-1978","CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2OC(C)C(O)C2O",{"v":0.82,"d":"0.820"},5,3,7]
["S1163","Onalespib (AT13387)","c5","L4700-01","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.",409.52,"912999-49-6",{"v":25,"d":"25.00"},61.05,"<1",null,"http://selleckchem.com/products/at13387.html","C24H31N3O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C(=O)N2CC3=C(C2)C=C(CN4CCN(C)CC4)C=C3",3.322,1,2,4]
["S1185","Ritonavir (ABT-538)","d5","L4700-01","in 10mM DMSO","Apoptosis related,COVID-19,HIV Protease,P450 (e.g. CYP17)","Proteases","Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.",720.94,"155213-67-5",{"v":100,"d":"100.00"},138.71,"<1",null,"http://selleckchem.com/products/Ritonavir.html","C37H48N6O5S2","free base","ABT-538,A 84538, RTV, Norvir, Norvir Softgel","CC(C)C(NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)CC4=CC=CC=C4",4.978,6,4,18]
["S1189","Aprepitant (MK-0869)","e5","L4700-01","in 10mM DMSO","CSF-1R,HIV,Interleukins,Neurokinin Receptor,TNF-alpha","Neuronal Signaling","Aprepitant (MK-0869, L-754030, Emend) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.",534.43,"170729-80-3",{"v":107,"d":"107.00"},200.21,"<1",null,"http://selleckchem.com/products/Aprepitant.html","C23H21F7N4O3","free base","MK-0869, L-754030, Emend","CC(OC1OCCN(CC2=NNC(=O)N2)C1C3=CC=C(F)C=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",4.635,4,2,8]
["S1193","Thalidomide (K17)","f5","L4700-01","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.",258.23,"50-35-1",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1",null,"http://selleckchem.com/products/Thalidomide.html","C13H10N2O4","free base","K17","O=C1CCC(N2C(=O)C3=C(C=CC=C3)C2=O)C(=O)N1",0.097,4,1,1]
["S1199","Cladribine (RWJ 26251)","g5","L4700-01","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.",285.69,"4291-63-8",{"v":57,"d":"57.00"},199.52,"<1",null,"http://selleckchem.com/products/Cladribine.html","C10H12ClN5O3","free base","Leustatin,2-CdA,2-Chloro-2′-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251","NC1=NC(=NC2=C1N=C[N]2C3CC(O)C(CO)O3)Cl",-0.259,4,3,2]
["S1204","Melatonin (NSC 113928)","h5","L4700-01","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1",null,"http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1210","Methotrexate (CL-14377)","a6","L4700-01","in 10mM DMSO","ADC Cytotoxin,DHFR","Metabolism","Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.",454.44,"59-05-2",{"v":90,"d":"90.00"},198.05,"<1",null,"http://selleckchem.com/products/Abitrexate.html","C20H22N8O5","free base","NCI-C04671, Amethopterin, CL14377, WR19039, abitrexate","CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",0.114,7,3,9]
["S1212","Bendamustine (SDX105) HCl","b6","L4700-01","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.",394.72,"3543-75-7",{"v":78,"d":"78.00"},197.61,{"v":2,"d":"2.00"},5.07,"http://selleckchem.com/products/Bendamustine-Hydrochloride.html","C16H21Cl2N3O2.HCl","Hydrochloride","Cytostasane HCl","Cl.C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCC(O)=O",3.988,2,0,9]
["S1223","Epirubicin (IMI 28) HCl","c6","L4700-01","in 10mM DMSO","Apoptosis related,Topoisomerase","DNA Damage/DNA Repair","Epirubicin HCl (Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin induces apoptosis.",579.98,"56390-09-1",{"v":100,"d":"100.00"},172.42,{"v":100,"d":"100.00"},172.42,"http://selleckchem.com/products/Ellence.html","C27H29NO11.HCl","Hydrochloride","Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1230","Flavopiridol (L86-8275)","d6","L4700-01","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.",401.84,"146426-40-6",{"v":15,"d":"15.00"},37.33,"<1",null,"http://selleckchem.com/products/Flavopiridol.html","C21H20ClNO5","Free Base","NSC 649890 HCl, HMR-1275, Alvocidib","CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",3.108,2,3,2]
["S1231","Topotecan (NSC609699) HCl","e6","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,Topoisomerase","DNA Damage/DNA Repair","Topotecan HCl (Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.",457.91,"119413-54-6",{"v":91,"d":"91.00"},198.73,{"v":91,"d":"91.00"},198.73,"http://selleckchem.com/products/Topotecan-Hydrochloride.html","C23H23N3O5.HCl","Hydrochloride","Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.959,4,1,3]
["S1237","Temozolomide (CCRG 81045)","f6","L4700-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.",194.15,"85622-93-1",{"v":38,"d":"38.00"},195.72,"<1",null,"http://selleckchem.com/products/Methazolastone.html","C6H6N6O2","free base","NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal","CN1N=NC2=C(N=C[N]2C1=O)C(N)=O",0.052,5,1,1]
["S1238","Tamoxifen (ICI 46474)","g6","L4700-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,ATPase,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Angiogenesis","Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.",371.51,"10540-29-1",{"v":74,"d":"74.00"},199.19,"<1",null,"http://selleckchem.com/products/Nolvadex.html","C26H29NO","Free Base","ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1241","Vincristine (NSC-67574) sulfate","h6","L4700-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.",923.04,"2068-78-2",{"v":100,"d":"100.00"},108.34,{"v":60,"d":"60.00"},{"v":65,"d":"65.00"},"http://selleckchem.com/products/Vincristine-Sulfate.html","C46H58N4O14S","free base","Leurocristine, Oncovin, NSC-67574, 22-Oxovincaleukoblastine","CCC1(O)CC2CN(CCC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=CC6=C(C=C5OC)N(C=O)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC67C89)C(=O)OC)C1.O[S](O)(=O)=O",3.365,8,1,10]
["S1243","Agomelatine (S20098)","a7","L4700-01","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Agomelatine (Valdoxan, Melitor, Thymanax,S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.",{"v":243.3,"d":"243.30"},"138112-76-2",{"v":48,"d":"48.00"},197.29,"<1",null,"http://selleckchem.com/products/Agomelatine.html","C15H17NO2","free base","Valdoxan, Melitor, Thymanax,S20098","COC1=CC2=C(CCNC(C)=O)C=CC=C2C=C1",{"v":2.17,"d":"2.170"},2,1,4]
["S1245","Latrepirdine 2HCl","b7","L4700-01","in 10mM DMSO","5-HT Receptor,GluR,Histamine Receptor","Neuronal Signaling","Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.",392.37,"97657-92-6",{"v":24,"d":"24.00"},61.17,"<1",null,"http://selleckchem.com/products/Dimebon.html","C21H25N3.2HCl","Dihydrochloride","N/A","Cl.Cl.CN1CCC2=C(C1)C3=C(C=CC(=C3)C)[N]2CCC4=CC=C(C)N=C4",4.769,1,0,3]
["S1251","Dienogest","c7","L4700-01","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.",311.42,"65928-58-7",{"v":62,"d":"62.00"},199.09,"<1",null,"http://selleckchem.com/products/Dienogest.html","C20H25NO2","free base","STS 557","CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC#N",3.046,1,0,1]
["S1255","Nepafenac","d7","L4700-01","in 10mM DMSO","COX","Neuronal Signaling","Nepafenac (AHR 9434, AL 6515) is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.",254.28,"78281-72-8",{"v":50,"d":"50.00"},196.63,"<1",null,"http://selleckchem.com/products/Nepafenac.html","C15H14N2O2","free base","AHR 9434, AL 6515","NC(=O)CC1=CC=CC(=C1N)C(=O)C2=CC=CC=C2",1.524,2,2,4]
["S1256","Rufinamide","e7","L4700-01","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Rufinamide (CGP 33101,E 2080,RUF 331,Banzel) is a voltage-gated sodium channel blocker, used an anticonvulsant medication.",238.19,"106308-44-5",{"v":18,"d":"18.00"},75.57,"<1",null,"http://selleckchem.com/products/Rufinamide.html","C10H8F2N4O","free base","CGP 33101,E 2080,RUF 331,Banzel","NC(=O)C1=C[N](CC2=C(F)C=CC=C2F)N=N1",1.437,3,1,3]
["S1259","Ramelteon","f7","L4700-01","in 10mM DMSO","MT Receptor","GPCR & G Protein","Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.",259.34,"196597-26-9",{"v":52,"d":"52.00"},200.51,"<1",null,"http://selleckchem.com/products/Ramelteon.html","C16H21NO2","free base","TAK-375","CCC(=O)NCCC1CCC2=CC=C3OCCC3=C12",2.826,2,1,4]
["S1261","Celecoxib (SC 58635)","g7","L4700-01","in 10mM DMSO","COX","Neuronal Signaling","Celecoxib (Celebrex, Celebra,SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.",381.37,"169590-42-5",{"v":76,"d":"76.00"},199.28,"<1",null,"http://selleckchem.com/products/Celecoxib.html","C17H14F3N3O2S","free base","Celebrex, Celebra,SC 58635","CC1=CC=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)(F)F",4.428,3,1,4]
["S1283","Asenapine maleate","h7","L4700-01","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor","Neuronal Signaling","Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.",401.84,"85650-56-2",{"v":80,"d":"80.00"},199.08,"<1",null,"http://selleckchem.com/products/Asenapine.html","C17H16ClNO.C4H4O4","Maleate","Org 5222","CN1CC2C(C1)C3=C(OC4=C2C=CC=C4)C=CC(=C3)Cl.OC(=O)\\C=C/C(O)=O",0.883,3,0,2]
["S1302","Ifosfamide (NSC109724)","a8","L4700-01","in 10mM DMSO","DNA alkylator,DNA/RNA Synthesis","DNA Damage/DNA Repair","Ifosfamide (Mitoxana, Ifex,Isophosphamide,NSC109724) is a nitrogen mustard alkylating agent used in the treatment of cancer.",261.09,"3778-73-2",{"v":52,"d":"52.00"},199.17,{"v":52,"d":"52.00"},199.17,"http://selleckchem.com/products/Ifosfamide.html","C7H15Cl2N2O2P","free base","Mitoxana, Ifex,Isophosphamide,NSC109724","ClCCN[P]1(=O)OCCCN1CCCl",0.144,2,1,5]
["S1305","Mercaptopurine (6-MP)","b8","L4700-01","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",152.18,"50-44-2",{"v":30,"d":"30.00"},197.13,"<1",null,"http://selleckchem.com/products/Mercaptopurine.html","C5H4N4S","free base","6-MP","S=C1N=CNC2=C1[NH]C=N2",0.367,2,2,0]
["S1322","Dexamethasone (MK-125)","c8","L4700-01","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1",null,"http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1326","Edaravone","d8","L4700-01","in 10mM DMSO","Antioxidant","ER stress & UPR","Edaravone (MCI-186) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.",{"v":174.2,"d":"174.20"},"89-25-8",{"v":35,"d":"35.00"},200.92,"<1",null,"http://selleckchem.com/products/Edaravone.html","C10H10N2O","free base","MCI-186","CC1=NN(C(=O)C1)C2=CC=CC=C2",1.123,2,0,1]
["S1328","Etodolac","e8","L4700-01","in 10mM DMSO","COX","Neuronal Signaling","Etodolac(AY-24236) is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.",287.35,"41340-25-4",{"v":58,"d":"58.00"},201.84,"<1",null,"http://selleckchem.com/products/Etodolac.html","C17H21NO3","free base","AY-24236","CCC1=CC=CC2=C1[NH]C3=C2CCOC3(CC)CC(O)=O",3.723,2,1,4]
["S1330","Felbamate","f8","L4700-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.",238.24,"25451-15-4",{"v":48,"d":"48.00"},201.48,"<1",null,"http://selleckchem.com/products/Felbamate.html","C11H14N2O4","free base","Felbatol, ADD-03055,W-554","NC(=O)OCC(COC(N)=O)C1=CC=CC=C1",0.984,4,2,7]
["S1331","Fluconazole (UK 49858)","g8","L4700-01","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Fluconazole (Diflucan, Trican, Alfumet,UK 49858) is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.",306.27,"86386-73-4",{"v":61,"d":"61.00"},199.17,"<1",null,"http://selleckchem.com/products/Fluconazole.html","C13H12F2N6O","free base","Diflucan, Trican, Alfumet,UK 49858","OC(C[N]1C=NC=N1)(C[N]2C=NC=N2)C3=C(F)C=C(F)C=C3",{"v":0.75,"d":"0.750"},4,0,5]
["S1333","Fluoxetine (Lilly 110140) HCl","h8","L4700-01","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.",345.79,"56296-78-7",{"v":69,"d":"69.00"},199.54,{"v":4,"d":"4.00"},11.57,"http://selleckchem.com/products/Fluoxetine-hydrochloride.html","C17H18F3NO.HCl","Hydrochloride","Prozac, Sarafem,LY-110140","Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2",4.415,1,1,7]
["S1336","Fluvoxamine (DU-23000) maleate","a9","L4700-01","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.",434.41,"61718-82-9",{"v":87,"d":"87.00"},200.27,"<1",null,"http://selleckchem.com/products/Fluvoxamine-maleate.html","C19H25F3N2O6","Maleate","MK-264,DU-23000 maleate","COCCCCC(=N\\OCCN)/C1=CC=C(C=C1)C(F)(F)F.OC(=O)\\C=C/C(O)=O",0.111,5,1,12]
["S1340","Gatifloxacin","b9","L4700-01","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Gatifloxacin (AM-1155, CG5501, BMS-206584) is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.",375.39,"112811-59-3",{"v":7,"d":"7.00"},18.65,"<1",null,"http://selleckchem.com/products/Gatifloxacin.html","C19H22FN3O4","free base","AM-1155, CG5501, BMS-206584","COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CCNC(C)C3)F)C4CC4",-0.909,3,1,4]
["S1342","Genistein (NPI 031L)","c9","L4700-01","in 10mM DMSO","EGFR,Topoisomerase","Protein Tyrosine Kinase","Genistein (NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK)  which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.",270.24,"446-72-0",{"v":54,"d":"54.00"},199.82,"<1",null,"http://selleckchem.com/products/Genistein.html","C15H10O5","free base","NPI 031L","OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O",{"v":2.14,"d":"2.140"},2,3,1]
["S1343","Ginkgolide B","d9","L4700-01","in 10mM DMSO","PAFR","GPCR & G Protein","Ginkgolide B (BN52021) is a PAFR antagonist with IC50 of 3.6 μM.",{"v":424.4,"d":"424.40"},"15291-77-7",{"v":85,"d":"85.00"},200.28,"<1",null,"http://selleckchem.com/products/Ginkgolide-B.html","C20H24O10","free base","BN52021","CC1C(=O)OC2C(O)C34C5CC(C(C)(C)C)C36C(O)C(=O)OC6OC4(C(=O)O5)C12O",-0.854,7,2,1]
["S1351","Ivermectin (MK-933)","e9","L4700-01","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1",null,"http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1356","Levetiracetam (UCB-L059)","f9","L4700-01","in 10mM DMSO","AChR,Calcium Channel","Transmembrane Transporters","Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.",170.21,"102767-28-2",{"v":34,"d":"34.00"},199.75,{"v":34,"d":"34.00"},199.75,"http://selleckchem.com/products/Levetiracetam.html","C8H14N2O2","free base","UCB-L059, SIB-S1","CCC(N1CCCC1=O)C(N)=O",-0.304,2,1,3]
["S1357","Lidocaine","g9","L4700-01","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.",234.34,"137-58-6",{"v":47,"d":"47.00"},200.56,{"v":9,"d":"9.00"},38.41,"http://selleckchem.com/products/Lidocaine.html","C14H22N2O","Free Base","Alphacaine","CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",2.626,1,1,5]
["S1358","Loratadine (SCH29851)","h9","L4700-01","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Loratadine (Alavert,Claritin,SCH29851) is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.",382.88,"79794-75-5",{"v":17,"d":"17.00"},{"v":44.4,"d":"44.40"},"<1",null,"http://selleckchem.com/products/Loratadine.html","C22H23ClN2O2","free base","Alavert,Claritin,SCH29851","CCOC(=O)N1CCC(CC1)=C2C3=C(CCC4=C2N=CC=C4)C=C(Cl)C=C3",{"v":5,"d":"5.000"},3,0,2]
["S1364","Patupilone (Epothilone B)","a10","L4700-01","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.",507.68,"152044-54-7",{"v":102,"d":"102.00"},200.91,"<1",null,"http://selleckchem.com/products/Epothilone-B.html","C27H41NO6S","free base","EPO906","CC1CCCC2(C)OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.779,5,2,2]
["S1380","Lopinavir (ABT-378)","b10","L4700-01","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.",{"v":628.8,"d":"628.80"},"192725-17-0",{"v":126,"d":"126.00"},200.38,"<1",null,"http://selleckchem.com/products/Lopinavir.html","C37H48N4O5","free base","ABT-378","CC(C)C(N1CCCNC1=O)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)COC3=C(C)C=CC=C3C)CC4=CC=CC=C4",4.926,4,4,15]
["S1385","Mosapride Citrate","c10","L4700-01","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Mosapride Citrate (TAK-370, AS-4370, Gasmotin) is a gastroprokinetic agent that acts as a selective 5HT4 agonist.",614.02,"112885-42-4",{"v":90,"d":"90.00"},146.58,"<1",null,"http://selleckchem.com/products/Mosapride-citrate.html","C21H25ClFN3O3.C6H8O7","Citrate","TAK-370, AS-4370, Gasmotin","CCOC1=CC(=C(Cl)C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(F)C=C3)N.OC(=O)CC(O)(CC(O)=O)C(O)=O",-1.422,6,2,12]
["S1390","Ondansetron HCl","d10","L4700-01","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ondansetron HCl (Ondemet, Emeset, Emetron,GR 38032F,SN 307) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.",329.82,"99614-01-4",{"v":66,"d":"66.00"},200.11,{"v":24,"d":"24.00"},72.77,"http://selleckchem.com/products/Ondansetron-hydrochloride.html","C18H19N3O.HCl","Hydrochloride","Ondemet, Emeset, Emetron,GR 38032F,SN 307","Cl.C[N]1C2=C(C(=O)C(CC2)C[N]3C=CN=C3C)C4=CC=CC=C14",3.016,2,0,2]
["S1391","Oxcarbazepine","e10","L4700-01","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.",252.27,"28721-07-5",{"v":7,"d":"7.00"},27.75,"<1",null,"http://selleckchem.com/products/Oxcarbazepine.html","C15H12N2O2","free base","GP47680","NC(=O)N1C2=C(CC(=O)C3=C1C=CC=C3)C=CC=C2",2.131,2,1,0]
["S1394","Pizotifen Malate","f10","L4700-01","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Pizotifen Malate (Sandomigran, pizotyline,BC-105) is a benzocycloheptane based agent used for recurrent migraine headaches.",429.53,"5189-11-7",{"v":21,"d":"21.00"},48.89,"<1",null,"http://selleckchem.com/products/Pizotifen-malate.html","C19H21NS.C4H6O5","Malate","Sandomigran, pizotyline,BC-105","CN1CCC(CC1)=C2C3=C(CCC4=C2C=CC=C4)SC=C3.OC(CC(O)=O)C(O)=O",0.292,2,1,3]
["S1396","Resveratrol (SRT501)","g10","L4700-01","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1",null,"http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1397","Rocuronium Bromide","h10","L4700-01","in 10mM DMSO","AChR","Neuronal Signaling","Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.",609.68,"119302-91-9",{"v":122,"d":"122.00"},{"v":200.1,"d":"200.10"},{"v":122,"d":"122.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Rocuronium-bromide.html","C32H53N2O4.Br","Bromide","ORG 9426","[Br-].CC(=O)OC1C(CC2C3CCC4CC(O)C(CC4(C)C3CCC12C)N5CCOCC5)[N+]6(CCCC6)CC=C",0.282,3,1,6]
["S1398","Stavudine (d4T)","a11","L4700-01","in 10mM DMSO","Reverse Transcriptase","Microbiology","Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.",224.21,"3056-17-5",{"v":45,"d":"45.00"},{"v":200.7,"d":"200.70"},"<1",null,"http://selleckchem.com/products/Stavudine.html","C10H12N2O4","free base","BMY-27857, Sanilvudine, NSC 163661,d4T","CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O",-0.515,3,2,2]
["S1401","Tenofovir","b11","L4700-01","in 10mM DMSO","Antiviral,COVID-19,Reverse Transcriptase","Microbiology","Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.",287.21,"147127-20-6",{"v":4,"d":"4.00"},13.93,{"v":2,"d":"2.00"},6.96,"http://selleckchem.com/products/Tenofovir.html","C9H14N5O4P","free base","GS-1278","CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O",-0.772,4,1,5]
["S1405","Vecuronium Bromide","c11","L4700-01","in 10mM DMSO","AChR","Neuronal Signaling","Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.",637.73,"50700-72-6",{"v":100,"d":"100.00"},156.81,{"v":4,"d":"4.00"},6.27,"http://selleckchem.com/products/Vecuronium-Bromide.html","C34H57N2O4.Br","Bromide","ORG NC45","[Br-].CC(=O)OC1CC2CCC3C(CCC4(C)C3CC(C4OC(C)=O)[N+]5(C)CCCCC5)C2(C)CC1N6CCCCC6",{"v":1.73,"d":"1.730"},4,0,6]
["S1430","Rolipram (ZK-62711)","d11","L4700-01","in 10mM DMSO","PDE","Metabolism","The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.",275.34,"61413-54-5",{"v":55,"d":"55.00"},199.75,"<1",null,"http://selleckchem.com/products/Rolipram.html","C16H21NO3","free base","ZK-62711, SB 95952","COC1=C(OC2CCCC2)C=C(C=C1)C3CNC(=O)C3",2.349,3,1,4]
["S1432","Sumatriptan Succinate","e11","L4700-01","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Sumatriptan Succinate (GR 43175) is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.",413.49,"103628-48-4",{"v":83,"d":"83.00"},200.73,{"v":83,"d":"83.00"},200.73,"http://selleckchem.com/products/Sumatriptan-succinate.html","C14H21N3O2S.C4H6O4","Succinate","GR 43175","CN[S](=O)(=O)CC1=CC=C2[NH]C=C(CCN(C)C)C2=C1.OC(=O)CCC(O)=O",-1.958,4,2,9]
["S1437","Tizanidine HCl","f11","L4700-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.",290.17,"64461-82-1",{"v":10,"d":"10.00"},34.46,{"v":15,"d":"15.00"},51.69,"http://selleckchem.com/products/Tizanidine-hydrochloride.html","C9H8ClN5S.HCl","Hydrochloride","DS 103-282","Cl.ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1",2.199,3,2,2]
["S1438","Topiramate","g11","L4700-01","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.",339.36,"97240-79-4",{"v":68,"d":"68.00"},200.38,"<1",null,"http://selleckchem.com/products/Topiramate.html","C12H21NO8S","free base","MCN 4853, RWJ 17021","CC1(C)OC2COC3(CO[S](N)(=O)=O)OC(C)(C)OC3C2O1",-1.932,6,1,3]
["S1441","Venlafaxine HCl","h11","L4700-01","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.",313.86,"99300-78-4",{"v":55.5,"d":"55.50"},176.83,{"v":55.5,"d":"55.50"},176.83,"http://selleckchem.com/products/Venlafaxine-hydrochloride.html","C17H27NO2.HCl","Hydrochloride","Wy 453 HCl","Cl.COC1=CC=C(C=C1)C(CN(C)C)C2(O)CCCCC2",3.404,1,0,5]
["S1442","Voriconazole (UK-109496)","a2","L4700-02","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Voriconazole (Vfend,UK-109496) is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.",349.31,"137234-62-9",{"v":70,"d":"70.00"},{"v":200.4,"d":"200.40"},"<1",null,"http://selleckchem.com/products/Voriconazole.html","C16H14F3N5O","free base","Vfend,UK-109496","CC(C1=NC=NC=C1F)C(O)(C[N]2C=NC=N2)C3=CC=C(F)C=C3F",2.071,4,0,5]
["S1444","Ziprasidone HCl","b2","L4700-02","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.",{"v":449.4,"d":"449.40"},"122883-93-6",{"v":90,"d":"90.00"},200.27,"<1",null,"http://selleckchem.com/products/Ziprasidone-hydrochloride.html","C21H21ClN4OS.HCl","Hydrochloride","CP-88059","Cl.ClC1=CC2=C(CC(=O)N2)C=C1CCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.641,2,1,4]
["S1445","Zonisamide","c2","L4700-02","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.",212.23,"68291-97-4",{"v":42,"d":"42.00"},{"v":197.9,"d":"197.90"},"<1",null,"http://selleckchem.com/products/Zonisamide.html","C8H8N2O3S","free base","Zonegran,CI-912,AD 810","N[S](=O)(=O)CC1=NOC2=CC=CC=C12",0.411,4,1,2]
["S1457","Atazanavir (BMS-232632) Sulfate","d2","L4700-02","in 10mM DMSO","HIV Protease","Proteases","Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.",802.93,"229975-97-7",{"v":104,"d":"104.00"},129.53,"<1",null,"http://selleckchem.com/products/Atazanavir.html","C38H52N6O7.H2SO4","Sulfate","BMS-232632-05, Reyataz","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C.O[S](O)(=O)=O",4.083,7,5,18]
["S1458","Neflamapimod (VX-745)","e2","L4700-02","in 10mM DMSO","p38 MAPK","MAPK","Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.",436.26,"209410-46-8",{"v":15,"d":"15.00"},34.38,"<1",null,"http://selleckchem.com/products/VX-745.html","C19H9Cl2F2N3OS","free base","N/A","FC1=CC(=C(SC2=NN3C=NC(=O)C(=C3C=C2)C4=C(Cl)C=CC=C4Cl)C=C1)F",5.342,3,0,3]
["S1483","Iloperidone","f2","L4700-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Iloperidone (HP873) is a dopamine (D2)/serotonin (5-HT2) receptor antagonist, used for the treatment of schizophrenia.",426.48,"133454-47-4",{"v":27,"d":"27.00"},63.31,"<1",null,"http://selleckchem.com/products/Iloperidone(Fanapt).html","C24H27FN2O4","free base","HP873","COC1=C(OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C=CC(=C1)C(C)=O",4.016,5,0,8]
["S1486","AEE788 (NVP-AEE788)","g2","L4700-02","in 10mM DMSO","EGFR,HER2,VEGFR","Protein Tyrosine Kinase","AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.",440.58,"497839-62-0",{"v":88,"d":"88.00"},199.74,"<1",null,"http://selleckchem.com/products/AEE788.html","C27H32N6","free base","N/A","CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC(C)C5=CC=CC=C5)N=CN=C4[NH]3",5.042,2,2,7]
["S1488","Naratriptan HCl","h2","L4700-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.",371.93,"143388-64-1",{"v":74,"d":"74.00"},198.96,{"v":22,"d":"22.00"},59.15,"http://selleckchem.com/products/Naratriptan(Amerge).html","C17H25N3O2S.HCl","Hydrochloride","N/A","Cl.CN[S](=O)(=O)CCC1=CC=C2[NH]C=C(C3CCN(C)CC3)C2=C1",2.435,2,2,5]
["S1497","Pralatrexate (NSC 754230)","a3","L4700-02","in 10mM DMSO","Apoptosis related,DHFR","Metabolism","Pralatrexate (NSC 754230) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.",477.47,"146464-95-1",{"v":28,"d":"28.00"},58.64,"<1",null,"http://selleckchem.com/products/Pralatrexate(Folotyn).html","C23H23N7O5","free base","NSC 754230","NC1=NC(=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1)N",{"v":1.94,"d":"1.940"},7,3,10]
["S1505","Aztreonam","b3","L4700-02","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.",435.43,"78110-38-0",{"v":87,"d":"87.00"},{"v":199.8,"d":"199.80"},{"v":11,"d":"11.00"},25.26,"http://selleckchem.com/products/Aztreonam(Azactam).html","C13H17N5O8S2","free base","SQ 26776","CC1C(NC(=O)\\C(=N/OC(C)(C)C(O)=O)C2=CSC(=N2)N)C(=O)N1[S](O)(=O)=O",-1.035,6,2,7]
["S1567","Pomalidomide (CC-4047)","c3","L4700-02","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.",273.24,"19171-19-8",{"v":54,"d":"54.00"},197.63,"<1",null,"http://selleckchem.com/products/Pomalidomide(CC-4047).html","C13H11N3O4","free base","CC-4047","NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",{"v":-0.65,"d":"-0.650"},4,2,1]
["S1576","Sulfasalazine (NSC 667219)","d3","L4700-02","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1",null,"http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1578","Candesartan (CV-11974)","e3","L4700-02","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.",440.45,"139481-59-7",{"v":88,"d":"88.00"},{"v":199.8,"d":"199.80"},"<1",null,"http://selleckchem.com/products/Candesartan(Atacand).html","C24H20N6O3","free base","CV-11974","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5)C(=CC=C2)C(O)=O",4.626,6,1,7]
["S1607","Rizatriptan Benzoate","f3","L4700-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Rizatriptan Benzoate (MK-462) is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.",391.47,"145202-66-0",{"v":20,"d":"20.00"},51.09,{"v":46,"d":"46.00"},117.51,"http://selleckchem.com/products/Rizatriptan-Benzoate(Maxalt).html","C22H25N5O2","Benzoate","MK-462 Benzoate","CN(C)CCC1=C[NH]C2=C1C=C(C[N]3C=NC=N3)C=C2.OC(=O)C4=CC=CC=C4",0.492,3,1,6]
["S1608","Pyridostigmine Bromide","g3","L4700-02","in 10mM DMSO","AChR","Neuronal Signaling","Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.",261.12,"101-26-8",{"v":52,"d":"52.00"},199.14,{"v":52,"d":"52.00"},199.14,"http://selleckchem.com/products/Pyridostigmine-Bromide(Mestinon).html","C9H13BrN2O2","Bromide","N/A","[Br-].CN(C)C(=O)OC1=C[N+](=CC=C1)C",-1.014,2,0,2]
["S1614","Riluzole (PK 26124)","h3","L4700-02","in 10mM DMSO","GluR,Sodium Channel","Transmembrane Transporters","Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.",{"v":234.2,"d":"234.20"},"1744-22-5",{"v":46,"d":"46.00"},196.41,"<1",null,"http://selleckchem.com/products/Riluzole(Rilutek).html","C8H5F3N2OS","free base","RP-54274, PK 26124","NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2",3.828,2,1,2]
["S1622","Prednisone (NSC-10023)","a4","L4700-02","in 10mM DMSO","Glucocorticoid Receptor,Immunology & Inflammation related","Endocrinology & Hormones","Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.",358.43,"53-03-2",{"v":71,"d":"71.00"},198.09,"<1",null,"http://selleckchem.com/products/Prednisone.html","C21H26O5","free base","Adasone,NSC-10023","CC12CC(=O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO",1.217,3,1,2]
["S1626","Naproxen Sodium","b4","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.",252.24,"26159-34-2",{"v":3,"d":"3.00"},11.89,{"v":50,"d":"50.00"},198.22,"http://selleckchem.com/products/Naproxen-Sodium(Aleve).html","C14H13NaO3","Sodium Salt","RS-3650","[Na+].COC1=CC=C2C=C(C=CC2=C1)C(C)C([O-])=O",1.375,1,0,3]
["S1638","Ibuprofen (NSC 256857)","c4","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Ibuprofen (NSC 256857, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.",206.28,"15687-27-1",{"v":41,"d":"41.00"},198.76,"<1",null,"http://selleckchem.com/products/Ibuprofen(Advil).html","C13H18O2","free base","Dolgesic,NSC 256857","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S1639","Amprenavir (VX-478)","d4","L4700-02","in 10mM DMSO","HIV Protease","Proteases","Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.",505.63,"161814-49-9",{"v":16,"d":"16.00"},31.64,"<1",null,"http://selleckchem.com/products/Amprenavir-(Agenerase).html","C25H35N3O6S","free base","141W94, VX-478, KVX-478","CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)[S](=O)(=O)C3=CC=C(N)C=C3",2.429,5,3,12]
["S1645","Ketoprofen","e4","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.",254.28,"22071-15-4",{"v":51,"d":"51.00"},200.57,"<1",null,"http://selleckchem.com/products/Ketoprofen(Actron).html","C16H14O3","free base","RP-19583","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S1646","Ketorolac","f4","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.",255.27,"74103-06-3",{"v":75,"d":"75.00"},293.81,"<1",null,"http://selleckchem.com/products/Ketorolac-Tromethamine(Toradol).html","C15H13N1O3","free base","N/A","OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",2.832,2,0,3]
["S1647","Adenosine","g4","L4700-02","in 10mM DMSO","Adenosine Receptor,Nucleoside Analog/Antimetabolite","GPCR & G Protein","Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.",267.24,"58-61-7",{"v":12,"d":"12.00"},{"v":44.9,"d":"44.90"},"<1",null,"http://selleckchem.com/products/Adenosine(Adenocard).html","C10H13N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-1.881,4,4,2]
["S1649","Zolmitriptan","h4","L4700-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Zolmitriptan(BW-311C90) is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.",287.36,"139264-17-8",{"v":58,"d":"58.00"},201.84,"<1",null,"http://selleckchem.com/products/Zolmitriptan(Zomig).html","C16H21N3O2","free base","BW-311C90","CN(C)CCC1=C[NH]C2=C1C=C(CC3COC(=O)N3)C=C2",2.457,2,2,5]
["S1653","Tretinoin (NSC 122758)","a5","L4700-02","in 10mM DMSO","Retinoid Receptor","Metabolism","Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.",{"v":300.4,"d":"300.40"},"302-79-4",{"v":60,"d":"60.00"},199.73,"<1",null,"http://selleckchem.com/products/Tretinoin(Aberela).html","C20H28O2","free base","Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1654","Phenylbutazone","b5","L4700-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.",308.37,"50-33-9",{"v":62,"d":"62.00"},201.06,"<1",null,"http://selleckchem.com/products/Phenylbutazone(Butazolidin).html","C19H20N2O2","free base","Butazolidine","CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3",3.954,2,0,5]
["S1662","Isradipine","c5","L4700-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Isradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.",371.39,"75695-93-1",{"v":74,"d":"74.00"},199.25,"<1",null,"http://selleckchem.com/products/Isradipine(Dynacirc).html","C19H21N3O5","free base","PN 200-110","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC3=NON=C23)C(=O)OC(C)C)C",2.168,7,1,6]
["S1666","Flucytosine","d5","L4700-02","in 10mM DMSO","Fungal","Microbiology","Flucytosine (5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915) is an antifungal drug with IC50 of 0.93 μM in C. albicans.",129.09,"2022-85-7",{"v":8,"d":"8.00"},61.97,{"v":5,"d":"5.00"},38.73,"http://selleckchem.com/products/Flucytosine(Ancobon).html","C4H4FN3O","free base","5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915","NC1=NC(=O)NC=C1F",-1.048,2,2,0]
["S1679","Flurbiprofen","e5","L4700-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).",244.26,"5104-49-4",{"v":49,"d":"49.00"},200.61,"<1",null,"http://selleckchem.com/products/Flurbiprofen(Ansaid).html","C15H13FO2","free base","N/A","CC(C(O)=O)C1=CC(=C(C=C1)C2=CC=CC=C2)F",{"v":3.68,"d":"3.680"},1,0,3]
["S1680","Disulfiram (NSC 190940)","f5","L4700-02","in 10mM DMSO","Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis","Metabolism","Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).",296.54,"97-77-8",{"v":59,"d":"59.00"},198.96,"<1",null,"http://selleckchem.com/products/Disulfiram(Antabuse).html","C10H20N2S4","free base","NSC 190940, Tetraethylthiuram disulfide, TETD","CCN(CC)C(=S)SSC(=S)N(CC)CC",{"v":5.6,"d":"5.600"},0,0,9]
["S1683","Ipratropium Bromide","g5","L4700-02","in 10mM DMSO","AChR","Neuronal Signaling","Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).",412.37,"22254-24-6",{"v":83,"d":"83.00"},201.28,{"v":83,"d":"83.00"},201.28,"http://selleckchem.com/products/Ipratropium-bromide.html","C20H30BrNO3","Bromide","N/A","[Br-].CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",-1.326,2,1,6]
["S1692","Busulfan (NSC-750)","h5","L4700-02","in 10mM DMSO","Apoptosis related,DNA alkylator","DNA Damage/DNA Repair","Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.",{"v":246.3,"d":"246.30"},"55-98-1",{"v":49,"d":"49.00"},198.94,"<1",null,"http://selleckchem.com/products/Busulfan(Busulfex).html","C6H14O6S2","free base","NSC-750","C[S](=O)(=O)OCCCCO[S](C)(=O)=O",-0.289,2,0,7]
["S1693","Carbamazepine","a6","L4700-02","in 10mM DMSO","Autophagy,Sodium Channel","Transmembrane Transporters","Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.",236.27,"298-46-4",{"v":47,"d":"47.00"},198.92,"<1",null,"http://selleckchem.com/products/Carbamazepine(Carbatrol).html","C15H12N2O","free base","NSC 169864","NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",2.679,1,1,0]
["S1702","Didanosine","b6","L4700-02","in 10mM DMSO","Reverse Transcriptase","Microbiology","Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.",236.23,"69655-05-6",{"v":47,"d":"47.00"},198.96,"<1",null,"http://selleckchem.com/products/Didanosine(Videx).html","C10H12N4O3","free base","N/A","OCC1CCC(O1)[N]2C=NC3=C2N=CNC3=O",-0.844,4,2,2]
["S1704","Emtricitabine (BW 1592)","c6","L4700-02","in 10mM DMSO","HBV,HIV,Reverse Transcriptase","Microbiology","Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.",247.25,"143491-57-0",{"v":49,"d":"49.00"},198.18,{"v":49,"d":"49.00"},198.18,"http://selleckchem.com/products/Emtricitabine.html","C8H10FN3O3S","free base","FTC, BW1592","NC1=NC(=O)N(C=C1F)C2CSC(CO)O2",{"v":-0.68,"d":"-0.680"},3,2,2]
["S1705","Progesterone (NSC 9704)","d6","L4700-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.",314.46,"57-83-0",{"v":22,"d":"22.00"},69.96,"<1",null,"http://selleckchem.com/products/Progesterone(Prometrium).html","C21H30O2","free base","NSC 64377, Pregn-4-ene-3,20-dione,NSC 9704","CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",{"v":3.86,"d":"3.860"},2,0,1]
["S1706","Lamivudine (BCH-189)","e6","L4700-02","in 10mM DMSO","COVID-19,Reverse Transcriptase","Microbiology","Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.",229.26,"134678-17-4",{"v":46,"d":"46.00"},200.65,{"v":46,"d":"46.00"},200.65,"http://selleckchem.com/products/Lamivudine(Epivir).html","C8H11N3O3S","free base","GR109714X, BCH-189","NC1=NC(=O)N(C=C1)C2CSC(CO)O2",{"v":-0.59,"d":"-0.590"},3,2,2]
["S1713","Piroxicam","f6","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.",331.35,"36322-90-4",{"v":66,"d":"66.00"},199.19,"<1",null,"http://selleckchem.com/products/Piroxicam(Feldene).html","C15H13N3O4S","free base","CP 16171","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.501,4,2,2]
["S1716","Glyburide (Glibenclamide)","g6","L4700-02","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.",{"v":494,"d":"494.00"},"10238-21-8",{"v":99,"d":"99.00"},{"v":200.4,"d":"200.40"},"<1",null,"http://selleckchem.com/products/Glyburide(Diabeta).html","C23H28ClN3O5S","free base","Glibenclamide","COC1=C(C=C(Cl)C=C1)C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCCCC3",{"v":4.14,"d":"4.140"},5,3,8]
["S1723","Indomethacin (NSC-77541)","h6","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Indomethacin (NSC-77541, Indometacin) is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.",357.79,"53-86-1",{"v":72,"d":"72.00"},201.24,"<1",null,"http://selleckchem.com/products/Indomethacin(Indocid).html","C19H16ClNO4","free base","Indometacin,NSC-77541","COC1=CC=C2[N](C(=C(CC(O)=O)C2=C1)C)C(=O)C3=CC=C(Cl)C=C3",4.235,3,0,4]
["S1725","Terbinafine","a7","L4700-02","in 10mM DMSO","Fungal","Microbiology","Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.",291.43,"91161-71-6",{"v":58,"d":"58.00"},199.02,"<1",null,"http://selleckchem.com/products/Terbinafine(Lamisil).html","C21H25N","Free Base","SF 86-327,TDT 067","CN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C12",5.335,0,0,6]
["S1733","Methylprednisolone (NSC-19987)","b7","L4700-02","in 10mM DMSO","ACE,Apoptosis related,Autophagy,Glucocorticoid Receptor,Immunology & Inflammation related,Interleukins","Endocrinology & Hormones","Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.",374.47,"83-43-2",{"v":75,"d":"75.00"},200.28,"<1",null,"http://selleckchem.com/products/Methylprednisolone.html","C22H30O5","free base","NSC-19987,U 7532","CC1CC2C3CCC(O)(C(=O)CO)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",1.512,2,2,2]
["S1734","Meloxicam","c7","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.",{"v":351.4,"d":"351.40"},"71125-38-7",{"v":30,"d":"30.00"},85.37,"<1",null,"http://selleckchem.com/products/Meloxicam(Mobic).html","C14H13N3O4S2","free base","N/A","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=C(C)S3",0.255,4,2,2]
["S1736","Methocarbamol","d7","L4700-02","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.",241.24,"532-03-6",{"v":48,"d":"48.00"},198.97,{"v":2,"d":"2.00"},8.29,"http://selleckchem.com/products/Methocarbamol(Robaxin).html","C11H15NO5","free base","AHR 85","COC1=C(OCC(O)COC(N)=O)C=CC=C1",0.916,4,2,7]
["S1737","Prednisolone (NSC-9900)","e7","L4700-02","in 10mM DMSO","Glucocorticoid Receptor,Immunology & Inflammation related","Endocrinology & Hormones","Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.",360.44,"50-24-8",{"v":72,"d":"72.00"},199.76,"<1",null,"http://selleckchem.com/products/Prednisolone(Hydroretrocortine).html","C21H28O5","Free Base","NSC-9900","CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO",{"v":1.26,"d":"1.260"},2,2,2]
["S1742","Nevirapine (NSC 641530)","f7","L4700-02","in 10mM DMSO","Reverse Transcriptase","Microbiology","Nevirapine (NSC 641530,NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.",{"v":266.3,"d":"266.30"},"129618-40-2",{"v":53,"d":"53.00"},199.02,"<1",null,"http://selleckchem.com/products/Nevirapine(Viramune).html","C15H14N4O","free base","NSC 641530,NVP","CC1=CC=NC2=C1NC(=O)C3=C(N=CC=C3)N2C4CC4",2.293,3,1,1]
["S1747","Nimodipine","g7","L4700-02","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.",418.44,"66085-59-4",{"v":84,"d":"84.00"},200.75,"<1",null,"http://selleckchem.com/products/Nimodipine(Nimotop).html","C21H26N2O7","free base","BAY E 9736","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C",2.361,5,1,10]
["S1754","Oxybutynin","h7","L4700-02","in 10mM DMSO","AChR","Neuronal Signaling","Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.",357.49,"5633-20-5",{"v":71,"d":"71.00"},198.61,"<1",null,"http://selleckchem.com/products/Oxybutynin(Ditropan).html","C22H31NO3","Free Base","N/A","CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C2=CC=CC=C2",4.646,2,0,10]
["S1761","Suprofen","a8","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Suprofen(TN-762) is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.",260.31,"40828-46-4",{"v":52,"d":"52.00"},199.76,"<1",null,"http://selleckchem.com/products/Suprofen(Profenal).html","C14H12O3S","free base","TN-762","CC(C(O)=O)C1=CC=C(C=C1)C(=O)C2=CC=CS2",3.314,2,0,4]
["S1762","Pyrazinamide","b8","L4700-02","in 10mM DMSO","Bacterial","Microbiology","Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.",123.11,"98-96-4",{"v":25,"d":"25.00"},203.07,{"v":12,"d":"12.00"},97.47,"http://selleckchem.com/products/Pyrazinamide(Pyrazinoic-acid-amide).html","C5H5N3O","free base","Pyrazinoic Acid Amide","NC(=O)C1=NC=CN=C1",-1.041,3,1,1]
["S1764","Rifampin (NSC-113926)","c8","L4700-02","in 10mM DMSO","Antibiotics for Plant Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Rifampin (NSC-113926, Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.",822.94,"13292-46-1",{"v":100,"d":"100.00"},121.52,"<1",null,"http://selleckchem.com/products/Rifampin(Rifadin).html","C43H58N4O12","free base","Rimactane, Rifampicin,NSC-113926","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(C)CC5",3.262,8,6,5]
["S1777","Ethionamide","d8","L4700-02","in 10mM DMSO","Antibiotics","Microbiology","Ethionamide (Bayer 5312) is an antibiotic used in the treatment of tuberculosis.",166.24,"536-33-4",{"v":33,"d":"33.00"},198.51,"<1",null,"http://selleckchem.com/products/Ethionamide.html","C8H10N2S","free base","Bayer 5312","CCC1=NC=CC(=C1)C(N)=S",1.498,1,1,2]
["S1789","Tetrabenazine (Xenazine)","e8","L4700-02","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Tetrabenazine(Xenazine,Ro 1-9569) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2.",317.42,"58-46-8",{"v":58,"d":"58.00"},182.72,"<1",null,"http://selleckchem.com/products/Tetrabenazine(Nitoman).html","C19H27NO3","free base","Xenazine,Ro 1-9569","COC1=CC2=C(C=C1OC)C3CC(=O)C(CC(C)C)CN3CC2",3.365,3,0,4]
["S1792","Simvastatin (MK 733)","f8","L4700-02","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1",null,"http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1805","Acetylcholine Chloride","g8","L4700-02","in 10mM DMSO","AChR","Neuronal Signaling","The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.",181.66,"60-31-1",{"v":36,"d":"36.00"},198.17,{"v":36,"d":"36.00"},198.17,"http://www.selleck.cn/products/Acetylcholine-chloride.html","C7H16NO2.Cl","Chloride","ACh chloride","[Cl-].CC(=O)OCC[N+](C)(C)C",-3.869,2,0,4]
["S1807","Aciclovir (BW 248U)","h8","L4700-02","in 10mM DMSO","Antiviral,Apoptosis related,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","Microbiology","Acyclovir (Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011,BW 248U) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.",{"v":225.2,"d":"225.20"},"59277-89-3",{"v":45,"d":"45.00"},199.82,"<1",null,"http://selleckchem.com/products/Acyclovir(Aciclovir).html","C8H11N5O3","free base","Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011,BW 248U","NC1=NC2=C(N=C[N]2COCCO)C(=O)N1",-1.423,4,3,4]
["S1832","Atracurium Besylate","a9","L4700-02","in 10mM DMSO","AChR","Neuronal Signaling","Atracurium Besylate (BW 33A, 51W89) is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.",1243.48,"64228-81-5",{"v":100,"d":"100.00"},80.42,{"v":33,"d":"33.00"},26.54,"http://selleckchem.com/products/atracurium-besylate.html","C53H72N2O12.2(C6H5O3S)","Dibesylate","BW 33A, 51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S1840","Lomustine","b9","L4700-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.",{"v":233.7,"d":"233.70"},"13010-47-4",{"v":46,"d":"46.00"},196.83,"<1",null,"http://selleckchem.com/products/Lomustine(CeeNU).html","C9H16ClN3O2","free base","NSC79037, Gleostine, CeeNU, CCNU","ClCCN(N=O)C(=O)NC1CCCCC1",2.394,2,1,4]
["S1845","Cimetidine","c9","L4700-02","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.",252.34,"51481-61-9",{"v":51,"d":"51.00"},202.11,"<1",null,"http://selleckchem.com/products/Cimetidine(Tagamet).html","C10H16N6S","free base","SKF-92334","CNC(NCCSCC1=C(C)[NH]C=N1)=NC#N",0.007,2,3,7]
["S1849","Daidzein","d9","L4700-02","in 10mM DMSO","PPAR","Metabolism","Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.",254.24,"486-66-8",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1",null,"http://selleckchem.com/products/Daidzein.html","C15H10O4","free base","N/A","OC1=CC=C(C=C1)C2=COC3=CC(=CC=C3C2=O)O",2.382,2,2,1]
["S1859","Diethylstilbestrol","e9","L4700-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Diethylstilbestrol (Stilbestrol) is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.",268.35,"56-53-1",{"v":54,"d":"54.00"},201.23,"<1",null,"http://selleckchem.com/products/Diethylstilbestrol(Stilbestrol).html","C18H20O2","free base","Stilbestrol","CCC(/C1=CC=C(O)C=C1)=C(CC)\\C2=CC=C(O)C=C2",5.137,0,2,4]
["S1866","Diphenhydramine HCl","f9","L4700-02","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Diphenhydramine HCl is a first-generation histamine H1 receptor antagonist, used in various allergic conditions such as rhinitis, urticaria and conjunctivitis.",291.82,"147-24-0",{"v":58,"d":"58.00"},198.75,{"v":58,"d":"58.00"},198.75,"http://selleckchem.com/products/Diphenhydramine-hydrochloride(Benadryl).html","C17H21NO.HCl","Hydrochloride","N/A","Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2",3.766,1,0,6]
["S1869","Dapoxetine HCl","g9","L4700-02","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.",341.87,"129938-20-1",{"v":68,"d":"68.00"},198.91,{"v":68,"d":"68.00"},198.91,"http://selleckchem.com/products/Dapoxetine-hydrochloride(Priligy).html","C21H23NO.HCl","Hydrochloride","LY-210448","Cl.CN(C)C(CCOC1=C2C=CC=CC2=CC=C1)C3=CC=CC=C3",4.917,1,0,6]
["S1878","Ganciclovir (BW 759)","h9","L4700-02","in 10mM DMSO","CMV","Microbiology","Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.",255.23,"82410-32-0",{"v":27,"d":"27.00"},105.79,"<1",null,"http://selleckchem.com/products/ganciclovir.html","C9H13N5O4","free base","RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine","NC1=NC2=C(N=C[N]2COC(CO)CO)C(=O)N1",-1.934,4,4,5]
["S1885","Felodipine","a10","L4700-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Felodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.",384.25,"72509-76-3",{"v":77,"d":"77.00"},200.39,"<1",null,"http://selleckchem.com/products/Felodipine(Plendil).html","C18H19Cl2NO4","free base","CGH-869","CCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",3.549,4,1,6]
["S1896","Hydroxyurea (NSC-32065)","b10","L4700-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,HIV","DNA Damage/DNA Repair","Hydroxyurea (NSC-32065, NCI-C04831, Hydroxycarbamide) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.",76.05,"127-07-1",{"v":15,"d":"15.00"},197.24,{"v":15,"d":"15.00"},197.24,"http://selleckchem.com/products/Hydroxyurea(Cytodrox).html","CH4N2O2","free base","NCI-C04831, Hydroxycarbamide,NSC-32065","NC(=O)NO",{"v":-1.03,"d":"-1.030"},1,2,0]
["S1898","Tropisetron HCl","c10","L4700-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tropisetron HCl (ICS 205-930) is a potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist, used to treat nausea and vomiting following chemotherapy.",320.81,"105826-92-4",{"v":35,"d":"35.00"},{"v":109.1,"d":"109.10"},{"v":46,"d":"46.00"},143.39,"http://selleckchem.com/products/Tropisetron-hydrochloride.html","C17H20N2O2.HCl","Hydrochloride","ICS 205-930","Cl.CN1C2CCC1CC(C2)OC(=O)C3C=NC4=CC=CC=C34",2.366,3,0,3]
["S1902","Vitamin B12","d10","L4700-02","in 10mM DMSO","Vitamin","Metabolism","Vitamin B12 (Cobalamin, Cyanocobalamin) is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.",1355.37,"68-19-9",{"v":75,"d":"75.00"},55.34,{"v":6,"d":"6.00"},4.43,"http://selleckchem.com/products/Vitamin-B12.html","C63H88CoN14O14P","free base","Cobalamin, Cyanocobalamin","CC(CNC(=O)CCC1(C)C(CC(N)=O)C2N=C1/C(=C/3N=C(/C=C/4N=C(/C(=C/5[N-]C2(C)C(C)(CC(N)=O)C5CCC(N)=O)C)C(C)(CC(N)=O)C4CCC(N)=O)C(C)(C)C3CCC(N)=O)C)O[P]([O-])(=O)OC6C(O)C(OC6CO)[N]7C=NC8=C7C=C(C)C(=C8)C.[Co++]C#N",-1.129,14,9,26]
["S1903","Diclofenac Sodium","e10","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac Sodium (GP 45840) is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.",318.13,"15307-79-6",{"v":64,"d":"64.00"},201.18,{"v":14,"d":"14.00"},44.01,"http://selleckchem.com/products/Diclofenac-sodium.html","C14H10Cl2NNaO2","Sodium Salt","GP 45840","[Na+].[O-]C(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",2.899,0,1,4]
["S1907","Metronidazole","f10","L4700-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.",171.15,"443-48-1",{"v":34,"d":"34.00"},198.66,"<1",null,"http://selleckchem.com/products/Metronidazole(Flagyl).html","C6H9N3O3","free base","N/A","CC1=NC=C([N]1CCO)[N+]([O-])=O",-0.337,1,1,3]
["S1913","Tropicamide","g10","L4700-02","in 10mM DMSO","AChR","Neuronal Signaling","Tropicamide(Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.",284.35,"1508-75-4",{"v":57,"d":"57.00"},200.46,"<1",null,"http://selleckchem.com/products/tropicamide.html","C17H20N2O2","free base","Ro 1-7683","CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2",1.432,2,1,6]
["S1914","Pregnenolone","h10","L4700-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.",316.48,"145-13-1",{"v":22,"d":"22.00"},69.51,"<1",null,"http://selleckchem.com/products/pregnenolone.html","C21H32O2","free base","3β-Hydroxy-5-pregnen-20-one","CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C",3.624,1,1,1]
["S1915","Sulfamethoxazole","a11","L4700-02","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sulfamethoxazole(Ro 4-2130) is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.",253.28,"723-46-6",{"v":51,"d":"51.00"},201.36,"<1",null,"http://selleckchem.com/products/Sulfamethoxazole.html","C10H11N3O3S","free base","Ro 4-2130","CC1=CC(=NO1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.709,4,2,3]
["S1920","Haloperidol","b11","L4700-02","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Haloperidol (Haldol) is an antipsychotic and butyrophenone.",375.86,"52-86-8",{"v":75,"d":"75.00"},199.54,"<1",null,"http://selleckchem.com/products/Haloperidol(Haldol).html","C21H23ClFNO2","free base","N/A","OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3",3.887,1,0,6]
["S1937","Isoniazid","c11","L4700-02","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.",137.14,"54-85-3",{"v":27,"d":"27.00"},196.88,{"v":27,"d":"27.00"},196.88,"http://selleckchem.com/products/Isoniazid(Tubizid).html","C6H7N3O","free base","N/A","NNC(=O)C1=CC=NC=C1",-0.811,2,2,1]
["S1940","Levofloxacin","d11","L4700-02","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.",361.37,"100986-85-4",{"v":24,"d":"24.00"},66.41,{"v":11,"d":"11.00"},30.44,"http://selleckchem.com/products/levofloxacin-levaquin.html","C18H20FN3O4","Free Base","Fluoroquinolone","CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F",-1.374,3,0,2]
["S1950","Metformin HCl","e11","L4700-02","in 10mM DMSO","Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK","Metabolism","Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",165.62,"1115-70-4",{"v":33,"d":"33.00"},199.25,{"v":33,"d":"33.00"},199.25,"http://selleckchem.com/products/Metformin-hydrochloride(Glucophage).html","C4H11N5.HCl","Hydrochloride","1,1-Dimethylbiguanide HCl","Cl.CN(C)C(=N)NC(N)=N",{"v":-0.36,"d":"-0.360"},0,2,3]
["S1956","Miconazole Nitrate","f11","L4700-02","in 10mM DMSO","Fungal","Microbiology","Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections.",479.14,"22832-87-7",{"v":96,"d":"96.00"},200.36,"<1",null,"http://selleckchem.com/products/Miconazole-nitrate.html","C18H14Cl4N2O.HNO3","Nitrate","NSC 169434 Nitrate","O[N+]([O-])=O.ClC1=CC=C(COC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C(=C1)Cl",4.387,2,0,6]
["S1959","Tolfenamic Acid","g11","L4700-02","in 10mM DMSO","COX","Neuronal Signaling","Tolfenamic Acid(Clotam) is a COX-2 inhibitor with IC50 of 0.2 μM.",{"v":261.7,"d":"261.70"},"13710-19-5",{"v":52,"d":"52.00"},{"v":198.7,"d":"198.70"},"<1",null,"http://selleckchem.com/products/tolfenamic-acid.html","C14H12ClNO2","free base","Clotam","CC1=C(Cl)C=CC=C1NC2=C(C=CC=C2)C(O)=O",{"v":4.16,"d":"4.160"},1,1,3]
["S1960","Pranoprofen","h11","L4700-02","in 10mM DMSO","COX,PGES","Neuronal Signaling","Pranoprofen (Pyranoprofen,Pranopulin) is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.",255.27,"52549-17-4",{"v":51,"d":"51.00"},199.79,"<1",null,"http://selleckchem.com/products/pranoprofen.html","C15H13NO3","free base","Pyranoprofen,Pranopulin","CC(C(O)=O)C1=CC2=C(OC3=NC=CC=C3C2)C=C1",{"v":3.05,"d":"3.050"},3,0,2]
["S1965","Primidone","a2","L4700-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.",218.25,"125-33-7",{"v":44,"d":"44.00"},{"v":201.6,"d":"201.60"},"<1",null,"http://selleckchem.com/products/Primidone(Mysoline).html","C12H14N2O2","free base","NCI-C56360","CCC1(C(=O)NCNC1=O)C2=CC=CC=C2",0.931,2,2,2]
["S1972","Tamoxifen (ICI 46474) Citrate","b2","L4700-03","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Endocrinology & Hormones","Tamoxifen Citrate (Istubal,ICI 46474 Citrate) is a selective estrogen receptor modulator (SERM). Tamoxifen Citrate is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis and autophagy.",563.64,"54965-24-1",{"v":100,"d":"100.00"},177.42,"<1",null,"http://selleckchem.com/products/Tamoxifen-Citrate(Nolvadex).html","C26H29NO.C6H8O7","Citrate","Istubal,ICI 46474 Citrate","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1975","Aripiprazole","c2","L4700-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.",448.39,"129722-12-9",{"v":90,"d":"90.00"},200.72,"<1",null,"http://selleckchem.com/products/aripiprazole-abilify.html","C23H27Cl2N3O2","free base","OPC-14597","ClC1=CC=CC(=C1Cl)N2CCN(CCCCOC3=CC=C4CCC(=O)NC4=C3)CC2",4.998,2,1,7]
["S1978","Methscopolamine","d2","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Methscopolamine is a muscarinic acetylcholine receptor blocker.",398.29,"155-41-9",{"v":79,"d":"79.00"},198.35,{"v":67,"d":"67.00"},168.22,"http://selleckchem.com/products/Methscopolamine-bromide(Pamine).html","C18H24BrNO4","quaternary-N bromide salt","N/A","[Br-].C[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",-2.949,3,1,5]
["S2006","Pyrimethamine","e2","L4700-03","in 10mM DMSO","DHFR","Metabolism","Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.",248.71,"58-14-0",{"v":10,"d":"10.00"},40.21,"<1",null,"http://selleckchem.com/products/Pyrimethamine.html","C12H13ClN4","free base","RP 4753","CCC1=NC(=NC(=C1C2=CC=C(Cl)C=C2)N)N",{"v":2.75,"d":"2.750"},2,2,2]
["S2007","Sulindac","f2","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.",356.41,"38194-50-2",{"v":71,"d":"71.00"},199.21,"<1",null,"http://selleckchem.com/products/Sulindac(Clinoril).html","C20H17FO3S","free base","MK-231","CC1=C(CC(O)=O)C2=C(C=CC(=C2)F)\\C1=C/C3=CC=C(C=C3)[S](C)=O",3.639,2,0,4]
["S2011","Pramipexole 2HCl Monohydrate","g2","L4700-03","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.",302.26,"191217-81-9",{"v":41,"d":"41.00"},135.64,{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/Pramipexole-dihydrochloride-monohydrate.html","C10H17N3S.2HCl.H2O","Dihydrochloride monohydrate","N/A","O.Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",{"v":1.94,"d":"1.940"},1,2,3]
["S2016","Mirtazapine","h2","L4700-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Mirtazapine (Org3770,6-Azamianserin) is an adrenergic and seroton receptor antagonist, used to treat depression.",265.35,"85650-52-8",{"v":53,"d":"53.00"},199.74,"<1",null,"http://selleckchem.com/products/mirtazapine-remeron-avanza.html","C17H19N3","free base","Org3770,6-Azamianserin","CN1CCN2C(C1)C3=C(CC4=C2N=CC=C4)C=CC=C3",3.094,1,0,0]
["S2024","Ketotifen Fumarate","a3","L4700-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ketotifen Fumarate(HC 20511 fumarate) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.",{"v":425.5,"d":"425.50"},"34580-14-8",{"v":8,"d":"8.00"},{"v":18.8,"d":"18.80"},"<1",null,"http://selleckchem.com/products/ketotifen-fumarate-zaditor.html","C19H19NOS.C4H4O4","Fumarate","HC 20511 fumarate","CN1CCC(CC1)=C2C3=C(CC(=O)C4=C2C=CS4)C=CC=C3.OC(=O)\\C=C\\C(O)=O",0.772,3,0,2]
["S2025","Urapidil HCl","b3","L4700-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.",423.94,"64887-14-5",{"v":24,"d":"24.00"},56.61,{"v":85,"d":"85.00"},{"v":200.5,"d":"200.50"},"http://selleckchem.com/products/urapidil-hydrochloride.html","C20H29N5O3.HCl","Hydrochloride","N/A","Cl.COC1=CC=CC=C1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2",1.808,3,1,7]
["S2037","Candesartan Cilexetil","c3","L4700-03","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.",610.66,"145040-37-5",{"v":122,"d":"122.00"},199.78,"<1",null,"http://selleckchem.com/products/Candesartan-cilexetil-Atacand.html","C33H34N6O6","free base","TCV-116","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=N[NH]5)C(=CC=C2)C(=O)OC(C)OC(=O)OC6CCCCC6",6.913,10,1,13]
["S2040","Nimesulide","d3","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.",308.31,"51803-78-2",{"v":62,"d":"62.00"},{"v":201.1,"d":"201.10"},"<1",null,"http://selleckchem.com/products/Nimesulide.html","C13H12N2O5S","free base","N/A","C[S](=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O",2.195,3,1,5]
["S2041","Dyclonine HCl","e3","L4700-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Dyclonine HCl(Dyclocaine HCl) is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.",325.87,"536-43-6",{"v":15,"d":"15.00"},46.03,{"v":6,"d":"6.00"},18.41,"http://selleckchem.com/products/dyclonine-hydrochloride.html","C18H27NO2.HCl","Hydrochloride","Dyclocaine HCl","Cl.CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2",4.435,2,0,8]
["S2043","Memantine HCl","f3","L4700-03","in 10mM DMSO","NMDAR","Neuronal Signaling","Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.",215.76,"41100-52-1",{"v":43,"d":"43.00"},{"v":199.3,"d":"199.30"},{"v":30,"d":"30.00"},139.04,"http://selleckchem.com/products/memantine-hydrochloride-namenda.html","C12H21N.HCl","Hydrochloride","N/A","Cl.CC12C[CH]3CC(C)([CH2]1)C[C](N)(C3)C2",2.289,0,1,0]
["S2044","Cyproheptadine HCl","g3","L4700-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cyproheptadine HCl(Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.",323.86,"969-33-5",{"v":65,"d":"65.00"},{"v":200.7,"d":"200.70"},"<1",null,"http://selleckchem.com/products/cyproheptadine-hydrochloride-periactin.html","C21H21N.HCl","Hydrochloride","Periactin","Cl.CN1CCC(CC1)=C2C3=C(C=CC=C3)C=CC4=C2C=CC=C4",4.744,0,0,0]
["S2054","Orphenadrine Citrate","h3","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.",{"v":461.5,"d":"461.50"},"4682-36-4",{"v":92,"d":"92.00"},199.35,"<1",null,"http://selleckchem.com/products/orphenadrine-citrate-norflex.html","C18H23NO.C6H8O7","Citrate","N/A","CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2C.OC(=O)CC(O)(CC(O)=O)C(O)=O",-0.483,4,0,11]
["S2061","Lovastatin (MK-803)","a4","L4700-03","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Lovastatin (MK-803, Mevinolin,Mevacor) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.",404.54,"75330-75-5",{"v":8,"d":"8.00"},19.78,"<1",null,"http://selleckchem.com/products/lovastatin-mevacor.html","C24H36O5","free base","Mevinolin,Mevacor","CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.218,4,1,7]
["S2077","Atorvastatin Calcium","b4","L4700-03","in 10mM DMSO","Apoptosis related,Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.",1155.34,"134523-03-8",{"v":100,"d":"100.00"},86.55,"<1",null,"http://selleckchem.com/products/atorvastatin-calcium-lipitor.html","2(C33H34FN2O5).Ca","Calcium","N/A","[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8",8.163,2,6,24]
["S2082","Adiphenine HCl","c4","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug.",347.88,"50-42-0",{"v":30,"d":"30.00"},86.24,{"v":70,"d":"70.00"},201.22,"http://selleckchem.com/products/adiphenine-hcl.html","C20H25NO2.HCl","HCl","NSC 129224","Cl.CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2",4.433,2,0,9]
["S2084","Duloxetine HCl","d4","L4700-03","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).",333.88,"136434-34-9",{"v":67,"d":"67.00"},200.67,"<1",null,"http://selleckchem.com/products/duloxetine-hcl-cymbalta.html","C18H19NOS.HCl","HCl","LY-248686 HCl","Cl.CNCCC(OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3",4.228,1,1,6]
["S2087","Rivastigmine Tartrate","e4","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Rivastigmine Tartrate (ENA 713) is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.",400.42,"129101-54-8",{"v":42,"d":"42.00"},104.89,{"v":80,"d":"80.00"},199.79,"http://selleckchem.com/products/rivastigmine-tartrate-exelon.html","C14H22N2O2.C4H6O6","Tartrate","ENA 713","CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.OC(C(O)C(O)=O)C(O)=O",-2.099,4,2,8]
["S2090","Dexmedetomidine HCl","f4","L4700-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.",236.74,"145108-58-3",{"v":48,"d":"48.00"},202.75,"<1",null,"http://selleckchem.com/products/dexmedetomidine-hcl-precedex.html","C13H16N2.HCl","HCl","(+)-Medetomidine Hydrochloride","Cl.CC(C1=CN=C[NH]1)C2=CC=CC(=C2C)C",3.378,1,1,2]
["S2096","Almotriptan Malate","g4","L4700-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Almotriptan Malate (LAS 31416) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.",469.55,"181183-52-8",{"v":94,"d":"94.00"},200.19,"<1",null,"http://selleckchem.com/products/almotriptan-malate-axert.html","C17H25N3O2S.C4H6O5","Malate","LAS 31416","CN(C)CCC1=C[NH]C2=CC=C(C[S](=O)(=O)N3CCCC3)C=C12.OC(CC(O)=O)C(O)=O",-1.943,4,2,9]
["S2102","Rasagiline Mesylate","h4","L4700-03","in 10mM DMSO","MAO","Metabolism","Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.",267.34,"161735-79-1",{"v":53,"d":"53.00"},198.25,{"v":53,"d":"53.00"},198.25,"http://selleckchem.com/products/rasagiline-mesylate.html","C12H13N.CH4O3S","Mesylate","TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate","C[S](O)(=O)=O.C#CCNC1CCC2=CC=CC=C12",2.705,0,1,2]
["S2108","Flunixin Meglumin","a5","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Flunixin Meglumin(Banamine) is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.",491.46,"42461-84-7",{"v":98,"d":"98.00"},199.41,{"v":98,"d":"98.00"},199.41,"http://selleckchem.com/products/flunixin-meglumin.html","C14H11F3N2O2.C7H17NO5","Meglumin","Banamine","CNCC(O)C(O)C(O)C(O)CO.CC1=C(C=CC=C1NC2=NC=CC=C2C(O)=O)C(F)(F)F",-1.676,2,7,10]
["S2111","Lapatinib (GW-572016)","b5","L4700-03","in 10mM DMSO","Autophagy,EGFR,Ferroptosis,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.",581.06,"231277-92-2",{"v":100,"d":"100.00"},{"v":172.1,"d":"172.10"},"<1",null,"http://selleckchem.com/products/lapatinib.html","C29H26ClFN4O4S","free base","GSK572016, GW2016","C[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(=C5)F)C(=C4)Cl)C3=C2",6.041,6,2,11]
["S2113","Cisatracurium Besylate","c5","L4700-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Cisatracurium Besylate(51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.",1243.48,"96946-42-8",{"v":249,"d":"249.00"},200.24,{"v":47,"d":"47.00"},{"v":37.8,"d":"37.80"},"http://selleckchem.com/products/cisatracurium-besylate-nimbex.html","C53H72N2O12.2C6H5O3S","Besylate","51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S2116","Conivaptan HCl","d5","L4700-03","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Conivaptan HCl(YM 087) is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia.",535.04,"168626-94-6",{"v":107,"d":"107.00"},199.99,"<1",null,"http://selleckchem.com/products/conivaptan-hcl-vaprisol.html","C32H26N4O2.HCl","HCl","YM 087","Cl.CC1=NC2=C([NH]1)C3=C(C=CC=C3)N(CC2)C(=O)C4=CC=C(NC(=O)C5=C(C=CC=C5)C6=CC=CC=C6)C=C4",{"v":5.68,"d":"5.680"},3,2,4]
["S2119","Probucol","e5","L4700-03","in 10mM DMSO","LDL","Metabolism","Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.",516.84,"23288-49-5",{"v":103,"d":"103.00"},199.29,"<1",null,"http://selleckchem.com/products/probucol.html","C31H48O2S2","free base","DH-581","CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(O)C(=C2)C(C)(C)C)C(C)(C)C",9.779,0,2,8]
["S2128","Bazedoxifene (WAY-140424) HCl","f5","L4700-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bazedoxifene HCl (WAY-140424, TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of  23 nM and 89 nM, respectively.",507.06,"198480-56-7",{"v":101,"d":"101.00"},199.19,"<1",null,"http://selleckchem.com/products/bazedoxifene-hcl.html","C30H34N2O3.HCl","Hydrochloride","TSE-424","Cl.CC1=C([N](CC2=CC=C(OCCN3CCCCCC3)C=C2)C4=CC=C(O)C=C14)C5=CC=C(O)C=C5",7.602,1,2,7]
["S2130","Atropine sulfate monohydrate","g5","L4700-03","in 10mM DMSO","AChR,ADC Cytotoxin","Neuronal Signaling","Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.",694.83,"5908-99-6",{"v":139,"d":"139.00"},200.05,{"v":139,"d":"139.00"},200.05,"http://selleckchem.com/products/Atropine-sulfate-monohydrate.html","2(C17H23NO3).H2O.H2SO4","Sulfate monohydrate","N/A","O.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.628,4,2,10]
["S2156","LY2886721","h5","L4700-03","in 10mM DMSO","BACE","Neuronal Signaling","LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.",390.41,"1262036-50-9",{"v":9,"d":"9.00"},23.05,"<1",null,"http://selleckchem.com/products/LY-2886721.html","C18H16F2N4O2S","free base","N/A","NC1=NC2(COCC2CS1)C3=CC(=CC=C3F)NC(=O)C4=NC=C(F)C=C4",2.134,4,2,3]
["S2167","Bazedoxifene (TSE-424) acetate","a6","L4700-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bazedoxifene Acetate (WAY-140424,TSE-424 acetate) is a third generation selective estrogen receptor modulator (SERM).",530.65,"198481-33-3",{"v":100,"d":"100.00"},188.45,"<1",null,"http://selleckchem.com/products/Bazedoxifene-acetate.html","C30H34N2O3.C2H4O2","Acetate","WAY-140424,TSE-424 acetate","CC(O)=O.CC1=C([N](CC2=CC=C(OCCN3CCCCCC3)C=C2)C4=CC=C(O)C=C14)C5=CC=C(O)C=C5",3.981,2,2,7]
["S2170","Givinostat (ITF2357)","b6","L4700-03","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.",475.97,"732302-99-7",{"v":95,"d":"95.00"},199.59,"<1",null,"http://selleckchem.com/products/ITF2357(Givinostat).html","C24H27N3O4.HCl.H2O","Chloride","N/A","O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC3=CC=C(C=C3)C(=O)NO)C=C2",4.046,3,2,9]
["S2217","Irinotecan (CPT-11) HCl Trihydrate","c6","L4700-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.",677.18,"136572-09-3",{"v":100,"d":"100.00"},147.67,{"v":1,"d":"1.00"},1.48,"http://selleckchem.com/products/Irinotecan-Hcl-Trihydrate-Campto.html","C33H38N4O6.HCl.3H2O","HCl & trihydrat","CPT-11 HCl Trihydrate","O.O.O.Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=CC=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C15)C(O)(CC)C(=O)OC4",3.446,6,0,5]
["S2220","SB590885","d6","L4700-03","in 10mM DMSO","Raf","MAPK","SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.",453.54,"405554-55-4",{"v":5,"d":"5.00"},11.02,"<1",null,"http://selleckchem.com/products/SB590885.html","C27H27N5O2","free base","N/A","CN(C)CCOC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=C\\4C(=C3)CCC4=N\\O)C5=CC=NC=C5",4.503,4,1,7]
["S2222","PF-3716556","e6","L4700-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.",394.47,"928774-43-0",{"v":79,"d":"79.00"},200.27,"<1",null,"http://selleckchem.com/products/PF-3716556.html","C22H26N4O3","Free Base","N/A","CN(CCO)C(=O)C1=C[N]2C=C(C)N=C2C(=C1)NC3CCOC4=CC=CC(=C34)C",1.499,3,2,5]
["S2247","Buparlisib (BKM120)","f6","L4700-03","in 10mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.",410.39,"944396-07-0",{"v":82,"d":"82.00"},199.81,"<1",null,"http://selleckchem.com/products/BKM-120.html","C18H21F3N6O2","free base","NVP-BKM120","NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F",2.342,5,1,4]
["S2286","Cyclosporin A (NSC 290193)","g6","L4700-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Complement System,Immunology & Inflammation related,phosphatase","Immunology & Inflammation","Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.",1202.61,"59865-13-3",{"v":100,"d":"100.00"},83.15,"<1",null,"http://selleckchem.com/products/Cyclosporin-A(Cyclosporine-A).html","C62H111N11O12","free base","Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193","CCC1NC(=O)C(C(O)C(C)C\\C=C\\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C",4.333,11,5,15]
["S2287","Cytisine","h6","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.",190.24,"485-35-8",{"v":38,"d":"38.00"},199.75,{"v":38,"d":"38.00"},199.75,"http://selleckchem.com/products/Cytisine(Baphitoxine,-Sophorine).html","C11H14N2O","free base","Baphitoxine,Sophorine","O=C1C=CC=C2C3CNCC(C3)CN12",-0.338,1,1,0]
["S2300","Ferulic Acid","a7","L4700-03","in 10mM DMSO","FGFR","Angiogenesis","Ferulic Acid (Fumalic) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong. Ferulic acid is a novel fibroblast growth factor receptor (FGFR) inhibitor with IC50s of 3.78 μM and 12.5 μM for FGFR1 and FGFR2, respectively.",194.19,"1135-24-6",{"v":39,"d":"39.00"},200.83,"<1",null,"http://selleckchem.com/products/Fumalic-acid(Ferulic-acid).html","C10H10O4","free base","Fumalic Acid","COC1=CC(=CC=C1O)\\C=C\\C(O)=O",1.669,2,1,3]
["S2310","Honokiol (NSC 293100)","b7","L4700-03","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1",null,"http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2346","Puerarin","c7","L4700-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.",416.38,"3681-99-0",{"v":86,"d":"86.00"},206.54,"<1",null,"http://selleckchem.com/products/Puerarin(Kakonein).html","C21H20O9","free base","Kakonein","OCC1OC(OC2=C(O)C=CC3=C2OC=C(C3=O)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S2349","Rutaecarpine","d7","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.",287.32,"84-26-4",{"v":24,"d":"24.00"},83.53,"<1",null,"http://selleckchem.com/products/Rutaecarpine(Rutecarpine).html","C18H13N3O","free base","Rutecarpine","O=C1N2CCC3=C([NH]C4=C3C=CC=C4)C2=NC5=C1C=CC=C5",3.359,2,1,0]
["S2350","Rutin","e7","L4700-03","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1",null,"http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2351","Salicin","f7","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.",286.28,"138-52-3",{"v":57,"d":"57.00"},199.11,{"v":24,"d":"24.00"},83.83,"http://selleckchem.com/products/Salicin(Salicoside,-Salicine).html","C13H18O7","free base","Salicoside,Salicine","OCC1OC(OC2=CC=CC=C2CO)C(O)C(O)C1O",-0.947,2,5,4]
["S2371","Vanillylacetone","g7","L4700-03","in 10mM DMSO","NF-κB","NF-κB","Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.",194.23,"122-48-5",{"v":38,"d":"38.00"},195.64,{"v":10,"d":"10.00"},51.49,"http://selleckchem.com/products/Vanillylacetone.html","C11H14O3","free base","NSC 15335","COC1=CC(=CC=C1O)CCC(C)=O",1.792,2,1,4]
["S2410","Paeoniflorin (NSC 178886)","h7","L4700-03","in 10mM DMSO","COX,HIF","Immunology & Inflammation","Paeoniflorin (NSC 178886,Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin reduces COX-2 expression. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.",480.46,"23180-57-6",{"v":96,"d":"96.00"},199.81,{"v":96,"d":"96.00"},199.81,"http://selleckchem.com/products/paeoniflorin.html","C23H28O11","free base","NSC 178886,Peoniflorin","CC12CC3(O)OC(O1)C4(COC(=O)C5=CC=CC=C5)C3CC24OC6OC(CO)C(O)C(O)C6O",-1.283,6,4,7]
["S2451","Amantadine HCl","a8","L4700-03","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Amantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus.",{"v":187.7,"d":"187.70"},"665-66-7",{"v":38,"d":"38.00"},202.45,{"v":38,"d":"38.00"},202.45,"http://selleckchem.com/products/Amantadine-hydrochloride(Symmetrel).html","C10H17N.HCl","Hydrochloride","1-adamantanamine HCl","Cl.N[C]12CC3[CH2][CH](C[CH]([CH2]3)C1)C2",1.877,0,1,0]
["S2452","Amfebutamone (Bupropion) HCl","b8","L4700-03","in 10mM DMSO","AChR,Dopamine Receptor","Neuronal Signaling","Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.",{"v":276.2,"d":"276.20"},"31677-93-7",{"v":8,"d":"8.00"},28.96,"<1",null,"http://selleckchem.com/products/Amfebutamone-hydrochloride(Bupropion).html","C13H18ClNO.HCl","Hydrochloride","Wellbutrin","Cl.CC(NC(C)(C)C)C(=O)C1=CC=CC(=C1)Cl",3.501,1,1,4]
["S2454","Bupivacaine HCl","c8","L4700-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.",324.89,"18010-40-7",{"v":65,"d":"65.00"},200.07,{"v":23,"d":"23.00"},70.79,"http://selleckchem.com/products/Bupivacaine-hydrochloride(Marcain).html","C18H28N2O.HCl","Hydrochloride","N/A","Cl.CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.692,1,1,5]
["S2455","Bethanechol chloride","d8","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Bethanechol chloride(Myocholine,Urecholine) is a selective muscarinic receptor agonist without any effect on nicotinic receptors.",196.68,"590-63-6",{"v":39,"d":"39.00"},198.29,{"v":39,"d":"39.00"},198.29,"http://selleckchem.com/products/Carbamyl-beta-methylcholine-chloride(Bethanechol-chloride).html","C7H17N2O2.Cl","quaternary-N Chloride salt","Myocholine,Urecholine","[Cl-].CC(C[N+](C)(C)C)OC(N)=O",-3.702,2,1,4]
["S2458","Clonidine HCl","e8","L4700-03","in 10mM DMSO","Adrenergic Receptor,Autophagy","Neuronal Signaling","Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.",{"v":266.5,"d":"266.50"},"4205-91-8",{"v":53,"d":"53.00"},198.87,{"v":53,"d":"53.00"},198.87,"http://selleckchem.com/products/Clonidine-hydrochloride(Catapres).html","C9H9Cl2N3.HCl","Hydrochloride","Kapvay","Cl.ClC1=C(NC2=NCCN2)C(=CC=C1)Cl",2.736,1,2,2]
["S2459","Clozapine","f8","L4700-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Clozapine (HF 1854, LX 100-129) is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.",326.82,"5786-21-0",{"v":65,"d":"65.00"},198.89,"<1",null,"http://selleckchem.com/products/Clozapine(Clozaril).html","C18H19ClN4","free base","HF 1854, LX 100-129","CN1CCN(CC1)C2=NC3=C(NC4=C2C=CC=C4)C=CC(=C3)Cl",3.422,1,1,1]
["S2460","Pramipexole","g8","L4700-03","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.",211.33,"104632-26-0",{"v":42,"d":"42.00"},198.74,"<1",null,"http://selleckchem.com/products/Pramipexole-Mirapex.html","C10H17N3S","Free Base","SND 919,Mirapexin,Sifrol,Mirapex","CCCNC1CCC2=C(C1)SC(=N2)N",1.383,1,2,3]
["S2461","Domperidone","h8","L4700-03","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.",425.91,"57808-66-9",{"v":48,"d":"48.00"},{"v":112.7,"d":"112.70"},"<1",null,"http://selleckchem.com/products/Domperidone(Motilium).html","C22H24ClN5O2","free base","N/A","ClC1=CC2=C(C=C1)N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)N2",2.453,2,2,5]
["S2466","Estriol","a9","L4700-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estriol (NSC-12169) is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.",288.39,"50-27-1",{"v":57,"d":"57.00"},197.65,"<1",null,"http://selleckchem.com/products/Estriol(Oestriol).html","C18H24O3","free base","NSC-12169","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CC(O)C2O",2.871,0,3,0]
["S2471","Gallamine Triethiodide","b9","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Gallamine Triethiodide  is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.",891.53,"65-29-2",{"v":100,"d":"100.00"},112.17,{"v":100,"d":"100.00"},112.17,"http://selleckchem.com/products/Gallamine-triethiodide(Flaxedil).html","C30H60I3N3O3","tri-quaternary-N iodide salt","N/A","[I-].[I-].[I-].CC[N+](CC)(CC)CCOC1=C(OCC[N+](CC)(CC)CC)C(=CC=C1)OCC[N+](CC)(CC)CC",-8.065,3,0,21]
["S2493","Olanzapine","c9","L4700-03","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.",312.44,"132539-06-1",{"v":62,"d":"62.00"},198.44,"<1",null,"http://selleckchem.com/products/Olanzapine(Zyprexa).html","C17H20N4S","free base","LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera","CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3",{"v":2.69,"d":"2.690"},1,1,1]
["S2497","Pancuronium dibromide","d9","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Pancuronium dibromide(Pavulon) is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.",732.67,"15500-66-0",{"v":100,"d":"100.00"},136.49,{"v":100,"d":"100.00"},136.49,"http://selleckchem.com/products/Pancuronium-bromide(Pavulon).html","C35H60N2O4.2Br","di-quaternary-N bromide salt","Pavulon","[Br-].[Br-].CC(=O)OC1CC2CCC3C(CCC4(C)C3CC(C4OC(C)=O)[N+]5(C)CCCCC5)C2(C)CC1[N+]6(C)CCCCC6",-2.043,4,0,6]
["S2504","Ribavirin (ICN-1229)","e9","L4700-03","in 10mM DMSO","Antiviral","Microbiology","Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.",244.21,"36791-04-5",{"v":49,"d":"49.00"},200.65,{"v":49,"d":"49.00"},200.65,"http://selleckchem.com/products/Ribavirin(Copegus).html","C8H12N4O5","free base","NSC-163039, RTCA, Tribavirin","NC(=O)C1=N[N](C=N1)C2OC(CO)C(O)C2O",-2.745,4,4,3]
["S2508","Scopolamine (LSM-4015) HBr","f9","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.",384.26,"114-49-8",{"v":76,"d":"76.00"},197.78,{"v":76,"d":"76.00"},197.78,"http://selleckchem.com/products/Scopolamine-hydrobromide.html","C17H21NO4.HBr","Hydrobromide","LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide","Br.CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",1.314,3,1,5]
["S2524","Phenytoin Sodium","g9","L4700-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Phenytoin Sodium (Aleviatin, Diphenylhydantoin sodium, Eptoin, Phenytoin soluble, Prompt; Phenytek,Dilantin sodium, Diphantoine) is an inactive voltage-gated sodium channel stabilizer.",274.25,"630-93-3",{"v":32,"d":"32.00"},116.68,{"v":3,"d":"3.00"},10.94,"http://selleckchem.com/products/Phenytoin-sodium-Dilantin.html","C15H11N2NaO2","Sodium Salt","Aleviatin, Diphenylhydantoin sodium, Eptoin, Phenytoin soluble, Prompt,Phenytek,Dilantin sodium, Diphantoine","[Na+].[O-]C1=NC(=O)C(N1)(C2=CC=CC=C2)C3=CC=CC=C3",2.084,2,1,2]
["S2525","Phenytoin","h9","L4700-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.",252.27,"57-41-0",{"v":50,"d":"50.00"},{"v":198.2,"d":"198.20"},"<1",null,"http://selleckchem.com/products/Phenytoin-Lepitoin.html","C15H12N2O2","Free Base","Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722","O=C1NC(=O)C(N1)(C2=CC=CC=C2)C3=CC=CC=C3",2.105,2,2,2]
["S2531","Asaraldehyde","a10","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.",{"v":196.2,"d":"196.20"},"4460-86-0",{"v":39,"d":"39.00"},198.78,"<1",null,"http://selleckchem.com/products/Asaraldehyde-Asaronaldehyde.html","C10H12O4","free base","Asaronaldehyde","COC1=C(OC)C=C(C=O)C(=C1)OC",{"v":1.54,"d":"1.540"},4,0,4]
["S2541","Clomipramine HCl","b10","L4700-03","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Clomipramine HCl(Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.",351.31,"17321-77-6",{"v":70,"d":"70.00"},199.25,{"v":70,"d":"70.00"},199.25,"http://selleckchem.com/products/Clomipramine-hydrochloride-Anafranil.html","C19H23ClN2.HCl","Hydrochloride","Anafranil","Cl.CN(C)CCCN1C2=C(CCC3=C1C=C(Cl)C=C3)C=CC=C2",5.434,0,0,4]
["S2547","Tiotropium Bromide hydrate","c10","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Tiotropium Bromide hydrate (BA 679BR) is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.",490.43,"139404-48-1",{"v":8,"d":"8.00"},16.31,"<1",null,"http://selleckchem.com/products/Tiotropium-Bromide-hydrate.html","C19H22NO4S2.Br.xH2O","quaternary-N bromide salt&hydr","BA 679BR","O.[Br-].C[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(O)(C4=CC=CS4)C5=CC=CS5",-1.727,3,0,5]
["S2549","Trospium chloride","d10","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Trospium chloride  is a competitive muscarinic cholinergic receptor antagonist.",427.96,"10405-02-4",{"v":41,"d":"41.00"},{"v":95.8,"d":"95.80"},{"v":86,"d":"86.00"},200.95,"http://selleckchem.com/products/Trospium-chloride-Sanctura.html","C25H30NO3.Cl","quaternary-N chloride salt","N/A","[Cl-].OC(C(=O)OC1CC2CCC(C1)[N+]23CCCC3)(C4=CC=CC=C4)C5=CC=CC=C5",-0.324,2,0,5]
["S2553","5-Aminolevulinic acid HCl","e10","L4700-03","in 10mM DMSO","Others","Others","5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.",167.59,"5451-09-2",{"v":34,"d":"34.00"},202.88,{"v":34,"d":"34.00"},202.88,"http://selleckchem.com/products/5-Aminolevulinic-acid-hydrochloride.html","C5H9NO3.HCl","Hydrochloride","5-ALA hydrochloride","Cl.NCC(=O)CCC(O)=O",-3.318,2,1,4]
["S2556","Rosiglitazone (BRL 49653)","f10","L4700-03","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",357.43,"122320-73-4",{"v":71,"d":"71.00"},198.64,"<1",null,"http://selleckchem.com/products/Rosiglitazone-Avandia.html","C18H19N3O3S","Free Base","BRL 49653","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",3.268,4,1,7]
["S2565","Amoxicillin Sodium","g10","L4700-03","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin Sodium (Clavulanate,Amoxycillin sodium) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.",387.39,"34642-77-8",{"v":78,"d":"78.00"},201.35,{"v":78,"d":"78.00"},201.35,"http://selleckchem.com/products/amoxicillin-amox.html","C16H18N3O5S.Na","Sodium Salt","Clavulanate,Amoxycillin sodium","[Na+].CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C([O-])=O",-1.534,2,3,4]
["S2570","Prednisolone Acetate","h10","L4700-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.",402.48,"52-21-1",{"v":81,"d":"81.00"},201.25,"<1",null,"http://selleckchem.com/products/Prednisolone-acetate-Omnipred.html","C23H30O6","free base","Omnipred,Prednisolone-21-acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C",1.639,4,1,4]
["S2577","Phenacetin","a11","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Phenacetin (Acetophenetidin) is a non-opioid analgesic without anti-inflammatory properties.",179.22,"62-44-2",{"v":36,"d":"36.00"},200.87,"<1",null,"http://selleckchem.com/products/phenacetin.html","C10H13NO2","free base","Acetophenetidin","CCOC1=CC=C(NC(C)=O)C=C1",1.282,2,1,3]
["S2579","Zidovudine","b11","L4700-03","in 10mM DMSO","CRISPR/Cas9,Reverse Transcriptase","Microbiology","Zidovudine (ZDV, Azidothymidine, NSC 602670,Retrovir) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.",267.24,"30516-87-1",{"v":53,"d":"53.00"},198.32,{"v":53,"d":"53.00"},198.32,"http://selleckchem.com/products/zidovudine-retrovir.html","C10H13N5O4","free base","Azidothymidine, NSC 602670,Retrovir","CC1=CN(C2CC(N=[N+]=[N-])C(CO)O2)C(=O)NC1=O",0.064,4,2,3]
["S2586","Dimethyl Fumarate","c11","L4700-03","in 10mM DMSO","Nrf2","Immunology & Inflammation","Dimethyl fumarate (DMF,Tecfidera,BG-12) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.",144.13,"624-49-7",{"v":29,"d":"29.00"},201.21,"<1",null,"http://selleckchem.com/products/dimethyl-Fumarate.html","C6H8O4","free base","DMF,Tecfidera,BG-12","COC(=O)\\C=C\\C(=O)OC",{"v":0.49,"d":"0.490"},4,0,4]
["S2602","Acemetacin","d11","L4700-03","in 10mM DMSO","COX","Neuronal Signaling","Acemetacin (K-708,TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.",415.82,"53164-05-9",{"v":83,"d":"83.00"},199.61,"<1",null,"http://selleckchem.com/products/acemetacin-emflex.html","C21H18ClNO6","free base","K-708,TVX 1322","COC1=CC2=C(C=C1)[N](C(=C2CC(=O)OCC(O)=O)C)C(=O)C3=CC=C(Cl)C=C3",3.942,5,0,7]
["S2614","Arecoline HBr","e11","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist.",236.11,"300-08-3",{"v":47,"d":"47.00"},199.06,{"v":47,"d":"47.00"},199.06,"https://www.selleckchem.com/products/arecoline-hbr.html","C8H13NO2.HBr","HBr","NSC-31750","Br.COC(=O)C1=CCCN(C)C1",1.234,2,0,2]
["S2621","AZD5438","f11","L4700-03","in 10mM DMSO","CDK","Cell Cycle","AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β.",371.46,"602306-29-6",{"v":74,"d":"74.00"},199.21,"<1",null,"http://selleckchem.com/products/AZD5438.html","C18H21N5O2S","free base","N/A","CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)[S](C)(=O)=O)C",2.966,5,1,5]
["S2624","OSI-027","g11","L4700-03","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1",null,"http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2629","PNU-120596","h11","L4700-03","in 10mM DMSO","AChR","Neuronal Signaling","PNU-120596 (Nsc 216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.",311.72,"501925-31-1",{"v":62,"d":"62.00"},{"v":198.9,"d":"198.90"},"<1",null,"http://selleckchem.com/products/pnu120596.html","C13H14ClN3O4","free base","Nsc 216666","COC1=CC(=C(NC(=O)NC2=NOC(=C2)C)C=C1Cl)OC",2.293,5,2,4]
["S2631","URB597","a2","L4700-04","in 10mM DMSO","FAAH","Metabolism","URB597 (KDS-4103) is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.",{"v":338.4,"d":"338.40"},"546141-08-6",{"v":68,"d":"68.00"},200.95,"<1",null,"http://selleckchem.com/products/urb597.html","C20H22N2O3","free base","KDS-4103","NC(=O)C1=CC(=CC=C1)C2=CC=CC(=C2)OC(=O)NC3CCCCC3",3.972,3,2,5]
["S2633","NPS-2143","b2","L4700-04","in 10mM DMSO","CaSR","GPCR & G Protein","NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.",408.92,"284035-33-2",{"v":82,"d":"82.00"},200.53,"<1",null,"http://selleckchem.com/products/nps-2143.html","C24H25ClN2O2","free base","SB262470","CC(C)(CC1=CC=C2C=CC=CC2=C1)NCC(O)COC3=C(C#N)C(=CC=C3)Cl",4.844,1,2,8]
["S2663","WAY-100635 Maleate","c2","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.",538.64,"1092679-51-0",{"v":85,"d":"85.00"},{"v":157.8,"d":"157.80"},"<1",null,"http://selleckchem.com/products/way-100635.html","C25H34N4O2.C4H4O4","Maleate","N/A","COC1=C(C=CC=C1)N2CCN(CC2)CCN(C(=O)C3CCCCC3)C4=NC=CC=C4.OC(=O)\\C=C/C(O)=O",1.427,5,0,9]
["S2673","Trametinib (GSK1120212)","d2","L4700-04","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.",615.39,"871700-17-3",{"v":22,"d":"22.00"},35.75,"<1",null,"http://selleckchem.com/products/gsk1120212-jtp-74057.html","C26H23FIN5O4","free base","JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(=CC=C5)NC(C)=O)C",3.176,4,2,5]
["S2677","BRL-15572 Dihydrochloride","e2","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.",479.87,"193611-72-2",{"v":96,"d":"96.00"},200.05,"<1",null,"https://www.selleckchem.com/products/brl-15572-dihydrochloride.html","C25H27ClN2O.2HCl","Dihydrochloride","N/A","Cl.Cl.OC(CN1CCN(CC1)C2=CC(=CC=C2)Cl)C(C3=CC=CC=C3)C4=CC=CC=C4",6.123,0,1,6]
["S2679","Flavopiridol (L86-8275) HCl","f2","L4700-04","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.",{"v":438.3,"d":"438.30"},"131740-09-5",{"v":88,"d":"88.00"},200.78,"<1",null,"http://selleckchem.com/products/flavopiridol-hydrochloride.html","C21H20ClNO5.HCl","Hydrochloride","NSC 649890, Alvocidib, HMR-1275, DSP-2033","Cl.CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,2]
["S2690","ADX-47273","g2","L4700-04","in 10mM DMSO","GluR","Neuronal Signaling","ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.",369.36,"851881-60-2",{"v":74,"d":"74.00"},200.35,"<1",null,"http://selleckchem.com/products/adx-47273.html","C20H17F2N3O2","free base","BA 94673139","FC1=CC=C(C=C1)C(=O)N2CCCC(C2)C3=NC(=NO3)C4=CC=C(F)C=C4",3.577,4,0,3]
["S2695","Nepicastat (SYN-117) HCl","h2","L4700-04","in 10mM DMSO","Hydroxylase","Metabolism","Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.",331.81,"170151-24-3",{"v":66,"d":"66.00"},198.91,"<1",null,"http://selleckchem.com/products/nepicastat-hydrochloride.html","C14H15F2N3S.HCl","Hydrochloride","N/A","Cl.NCC1=CNC(=S)N1C2CCC3=C(F)C=C(F)C=C3C2",3.008,0,2,2]
["S2698","RS-127445","a3","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","RS-127445 (MT500) is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.",281.33,"199864-87-4",{"v":56,"d":"56.00"},199.05,"<1",null,"http://selleckchem.com/products/rs-127445.html","C17H16FN3","free base","MT500","CC(C)C1=NC(=NC(=C1)C2=C3C=CC=CC3=C(F)C=C2)N",4.298,2,1,2]
["S2720","ZM 336372","b3","L4700-04","in 10mM DMSO","Raf","MAPK","ZM 336372 (Zinc00581684) is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.",389.45,"208260-29-1",{"v":78,"d":"78.00"},200.28,"<1",null,"http://selleckchem.com/products/zm-336372.html","C23H23N3O3","free base","Zinc00581684","CN(C)C1=CC=CC(=C1)C(=O)NC2=CC(=C(C)C=C2)NC(=O)C3=CC=C(O)C=C3",3.805,2,3,5]
["S2727","Dacomitinib (PF-00299804)","c3","L4700-04","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Dacomitinib (PF299804, PF299) is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.",469.94,"1110813-31-4",{"v":19,"d":"19.00"},40.43,"<1",null,"http://selleckchem.com/products/pf299804.html","C24H25ClFN5O2","free base","PF299804,PF299","COC1=C(NC(=O)/C=C/CN2CCCCC2)C=C3C(=NC=NC3=C1)NC4=CC(=C(F)C=C4)Cl",5.055,4,2,7]
["S2762","Alectinib (CH5424802)","d3","L4700-04","in 10mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (CH5424802, AF-802, RG-7853) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.",482.62,"1256580-46-7",{"v":6,"d":"6.00"},12.43,{"v":1,"d":"1.00"},2.07,"http://www.selleckchem.com/products/ch5424802.html","C30H34N4O2","Free Base","AF-802, RG-7853,CH5424802","CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C)(C)C5=C(C2=O)C6=CC=C(C=C6[NH]5)C#N",5.203,2,1,3]
["S2775","Nocodazole (R17934)","e3","L4700-04","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,CRISPR/Cas9,Microtubule Associated","Cytoskeletal Signaling","Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.",301.32,"31430-18-9",{"v":7,"d":"7.00"},23.23,"<1",null,"http://selleckchem.com/products/nocodazole.html","C14H11N3O3S","free base","Oncodazole, NSC238159","COC(=O)NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CS3",3.008,4,2,4]
["S2777","PF-5274857","f3","L4700-04","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.",436.96,"1373615-35-0",{"v":93,"d":"93.00"},212.83,{"v":93,"d":"93.00"},212.83,"http://selleckchem.com/products/pf-5274857.html","C20H25ClN4O3S","free base","N/A","CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CC[S](C)(=O)=O)C",2.744,5,0,5]
["S2784","TAK-285","g3","L4700-04","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.",547.96,"871026-44-7",{"v":110,"d":"110.00"},200.74,"<1",null,"http://selleckchem.com/products/tak-285.html","C26H25ClF3N5O3","free base","N/A","CC(C)(O)CC(=O)NCC[N]1C=CC2=C1C(=NC=N2)NC3=CC=C(OC4=CC=CC(=C4)C(F)(F)F)C(=C3)Cl",5.586,4,2,10]
["S2787","Laquinimod","h3","L4700-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.",{"v":356.8,"d":"356.80"},"248281-84-7",{"v":61,"d":"61.00"},170.96,"<1",null,"http://selleckchem.com/products/laquinimod-abr-215062.html","C19H17ClN2O3","free base","ABR-215062, LAQ","CCN(C(=O)C1=C(O)C2=C(C=CC=C2Cl)N(C)C1=O)C3=CC=CC=C3",2.884,2,1,3]
["S2796","WP1066","a4","L4700-04","in 10mM DMSO","Apoptosis related,JAK,STAT","JAK/STAT","WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.",356.22,"857064-38-1",{"v":71,"d":"71.00"},199.32,"<1",null,"http://selleckchem.com/products/wp1066.html","C17H14BrN3O","free base","N/A","CC(NC(=O)\\C(=C\\C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",3.566,2,1,4]
["S2797","Lonafarnib (SCH66336)","b4","L4700-04","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1",null,"http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2828","JNJ-1661010","c4","L4700-04","in 10mM DMSO","FAAH","Metabolism","JNJ-1661010 (Takeda-25) is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2.",365.45,"681136-29-8",{"v":36,"d":"36.00"},98.51,"<1",null,"http://selleckchem.com/products/jnj-1661010.html","C19H19N5OS","Free Base","Takeda-25","O=C(NC1=CC=CC=C1)N2CCN(CC2)C3=NC(=NS3)C4=CC=CC=C4",3.271,3,1,3]
["S2843","BI-D1870","d4","L4700-04","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1",null,"http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2849","SB269970 HCl","e4","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.",388.95,"261901-57-9",{"v":11,"d":"11.00"},28.28,"<1",null,"http://selleckchem.com/products/sb-269970-hcl.html","C18H28N2O3S.HCl","Hydrochloride","N/A","Cl.CC1CCN(CC1)CCC2CCCN2[S](=O)(=O)C3=CC=CC(=C3)O",2.946,2,1,5]
["S2852","BRL-54443","f4","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.",230.31,"57477-39-1",{"v":46,"d":"46.00"},199.73,"<1",null,"http://selleckchem.com/products/brl-54443.html","C14H18N2O","free base","N/A","CN1CCC(CC1)C2=C[NH]C3=C2C=C(O)C=C3",2.572,0,2,1]
["S2856","SB 271046 hydrochloride","g4","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB 271046 hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.",488.45,"209481-24-3",{"v":40,"d":"40.00"},81.89,"<1",null,"http://selleckchem.com/products/sb-271046.html","C20H22ClN3O3S2.HCl","hydrochloride","N/A","COC1=CC=C(N[S](=O)(=O)C2=C(C)C3=CC(=CC=C3S2)Cl)C=C1N4CCNCC4",4.403,3,2,5]
["S2865","VUF 10166","h4","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.",262.74,"155584-74-0",{"v":21,"d":"21.00"},79.93,"<1",null,"http://selleckchem.com/products/vuf-10166.html","C13H15ClN4","free base","N/A","CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl",2.826,2,0,1]
["S2875","Prucalopride","a5","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Prucalopride (R-93877) is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.",367.87,"179474-81-8",{"v":60,"d":"60.00"},{"v":163.1,"d":"163.10"},"<1",null,"http://selleckchem.com/products/prucalopride.html","C18H26ClN3O3","Free Base","R-93877","COCCCN1CCC(CC1)NC(=O)C2=CC(=C(N)C3=C2OCC3)Cl",1.056,3,2,6]
["S2892","VU 0361737","b5","L4700-04","in 10mM DMSO","GluR","Neuronal Signaling","VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.",262.69,"1161205-04-4",{"v":53,"d":"53.00"},201.76,"<1",null,"http://selleckchem.com/products/vu-0361737.html","C13H11ClN2O2","free base","N/A","COC1=CC(=CC=C1Cl)NC(=O)C2=NC=CC=C2",{"v":2.54,"d":"2.540"},3,1,3]
["S2894","SB742457","c5","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.",353.44,"607742-69-8",{"v":78,"d":"78.00"},220.69,"<1",null,"http://selleckchem.com/products/sb-742457.html","C19H19N3O2S","free base","GSK 742457","O=[S](=O)(C1=CC=CC=C1)C2=CC3=C(N=C2)C(=CC=C3)N4CCNCC4",2.702,3,1,3]
["S2903","Lumiracoxib","d5","L4700-04","in 10mM DMSO","COX","Neuronal Signaling","Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of  0.06 μM. It also inhibits COX1 with Ki of 3 μM.",293.72,"220991-20-8",{"v":59,"d":"59.00"},200.87,"<1",null,"http://selleckchem.com/products/lumiracoxib-cox-189.html","C15H13ClFNO2","free base","COX-189","CC1=CC=C(NC2=C(Cl)C=CC=C2F)C(=C1)CC(O)=O",{"v":4.4,"d":"4.400"},1,1,4]
["S2913","BAY 11-7082","e5","L4700-04","in 10mM DMSO","Apoptosis related,DUB,IκB/IKK","NF-κB","BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.",207.25,"19542-67-7",{"v":41,"d":"41.00"},197.83,"<1",null,"http://selleckchem.com/products/bay-11-7082-bay-11-7821.html","C10H9NO2S","free base","BAY 11-7821","CC1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",1.721,2,0,2]
["S2922","Icotinib (BPI-2009H)","f5","L4700-04","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Icotinib (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).",391.42,"610798-31-7",{"v":78,"d":"78.00"},199.27,"<1",null,"http://selleckchem.com/products/icotinib.html","C22H21N3O4","free base","BPI-2009H","C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C4OCCOCCOCCOC4=C3",4.128,6,1,2]
["S3005","Paroxetine HCl","g5","L4700-04","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.",365.83,"78246-49-8",{"v":73,"d":"73.00"},199.55,{"v":1,"d":"1.00"},2.73,"http://selleckchem.com/products/paroxetine-hcl.html","C19H20FNO3.HCl","Hydrochloride","BRL-29060A, FG-7051","Cl.FC1=CC=C(C=C1)C2CCNCC2COC3=CC4=C(OCO4)C=C3",3.611,3,1,4]
["S3008","Zaltoprofen","h5","L4700-04","in 10mM DMSO","COX","Neuronal Signaling","Zaltoprofen(CN100,Soleton) is an inhibitor of COX-1 and COX-2 for treatment of arthritis.",298.36,"74711-43-6",{"v":60,"d":"60.00"},{"v":201.1,"d":"201.10"},"<1",null,"http://selleckchem.com/products/zaltoprofen.html","C17H14O3S","free base","CN100,Soleton","CC(C(O)=O)C1=CC2=C(SC3=CC=CC=C3C(=O)C2)C=C1",3.684,2,0,2]
["S3012","Pazopanib","a6","L4700-04","in 10mM DMSO","Autophagy,Cathepsin B,c-Kit,CSF-1R,Cysteine Protease,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.",437.52,"444731-52-6",{"v":87,"d":"87.00"},198.85,"<1",null,"http://selleckchem.com/products/pazopanib.html","C21H23N7O2S","Free Base","GW786034","C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",3.741,5,2,5]
["S3017","Aspirin (NSC 27223)","b6","L4700-04","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1",null,"http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3018","Niflumic acid","c6","L4700-04","in 10mM DMSO","COX,GABA Receptor","Neuronal Signaling","Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.",282.22,"4394-00-7",{"v":56,"d":"56.00"},198.43,"<1",null,"http://selleckchem.com/products/niflumic-acid.html","C13H9F3N2O2","free base","Nifluril","OC(=O)C1=CC=CN=C1NC2=CC=CC(=C2)C(F)(F)F",{"v":3.34,"d":"3.340"},2,1,4]
["S3021","Rimonabant (SR141716)","d6","L4700-04","in 10mM DMSO","Acyltransferase,Bacterial,Cannabinoid Receptor,MmpL3,Transferase","GPCR & G Protein","Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.",463.79,"168273-06-1",{"v":25,"d":"25.00"},{"v":53.9,"d":"53.90"},"<1",null,"http://selleckchem.com/products/rimonabant-sr141716.html","C22H21Cl3N4O","free base","SR141716","CC1=C([N](N=C1C(=O)NN2CCCCC2)C3=CC=C(Cl)C=C3Cl)C4=CC=C(Cl)C=C4",6.613,2,1,4]
["S3022","Cabazitaxel (XRP6258)","e6","L4700-04","in 10mM DMSO","Autophagy,Microtubule Associated","Cytoskeletal Signaling","Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.",835.93,"183133-96-2",{"v":100,"d":"100.00"},119.63,"<1",null,"http://selleckchem.com/products/cabazitaxel-jevtana.html","C45H57NO14","free base","RPR-116258A, TXD 258, Taxoid XRP6258","COC1CC2OCC2(OC(C)=O)C3C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(OC)C(=O)C13C)C5(C)C)C",3.403,12,2,15]
["S3023","Bufexamac","f6","L4700-04","in 10mM DMSO","COX,IFN","Neuronal Signaling","Bufexamac(Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.",223.27,"2438-72-4",{"v":45,"d":"45.00"},201.55,"<1",null,"http://selleckchem.com/products/bufexamac.html","C12H17NO3","free base","Bufexamic acid","CCCCOC1=CC=C(CC(=O)NO)C=C1",2.191,2,1,6]
["S3024","Lamotrigine","g6","L4700-04","in 10mM DMSO","5-HT Receptor,Sodium Channel","Transmembrane Transporters","Lamotrigine (BW-430C,LTG) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.",256.09,"84057-84-1",{"v":10,"d":"10.00"},39.05,"<1",null,"http://selleckchem.com/products/lamotrigine.html","C9H7Cl2N5","free base","BW-430C,LTG","NC1=NC(=C(N=N1)C2=CC=CC(=C2Cl)Cl)N",2.426,3,2,1]
["S3043","Rofecoxib","h6","L4700-04","in 10mM DMSO","COX","Neuronal Signaling","Rofecoxib (MK-0966) is a COX-2 inhibitor with IC50 of 18 nM.",314.36,"162011-90-7",{"v":63,"d":"63.00"},200.41,"<1",null,"http://selleckchem.com/products/rofecoxib-vioxx.html","C17H14O4S","free base","MK-0966","C[S](=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3",2.871,4,0,3]
["S3047","Otilonium Bromide","a7","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Otilonium bromide is an antimuscarinic.",563.57,"26095-59-0",{"v":113,"d":"113.00"},200.51,{"v":113,"d":"113.00"},200.51,"http://selleckchem.com/products/otilonium-bromide.html","C29H43BrN2O4","quaternary-N bromide salt","N/A","[Br-].CCCCCCCCOC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)OCC[N+](C)(CC)CC",{"v":2.67,"d":"2.670"},4,1,17]
["S3054","Alverine Citrate","b7","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.",473.56,"5560-59-8",{"v":95,"d":"95.00"},200.61,"<1",null,"http://selleckchem.com/products/alverine-citrate.html","C20H27N.C6H8O7","Citrate","NSC 35459","CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.037,3,0,14]
["S3063","Diclofenac Diethylamine","c7","L4700-04","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.",369.29,"78213-16-8",{"v":74,"d":"74.00"},200.38,"<1",null,"http://selleckchem.com/products/diclofenac-diethylamine.html","C14H11Cl2NO2.C4H11N","Diethylamine","N/A","CCNCC.OC(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl",{"v":2.15,"d":"2.150"},1,2,6]
["S3117","Oxybutynin hydrochloride","d7","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Oxybutynin(MJ4309-1) is an anticholinergic medication used to relieve urinary and bladder difficulties.",393.95,"1508-65-2",{"v":79,"d":"79.00"},200.53,{"v":4,"d":"4.00"},10.15,"https://www.selleckchem.com/products/oxybutynin-hydrochloride.html","C22H31NO3.HCl","hydrochloride","MJ4309-1","Cl.CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C2=CC=CC=C2",5.028,2,0,10]
["S3124","Dexamethasone Acetate","e7","L4700-04","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1",null,"http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3133","Sulfamethazine","f7","L4700-04","in 10mM DMSO","Bacterial","Microbiology","Sulfamethazine(Sulfadimidine,Sulfadimerazine) is a sulfonamide antibacterial.",278.33,"57-68-1",{"v":56,"d":"56.00"},{"v":201.2,"d":"201.20"},"<1",null,"http://selleckchem.com/products/sulfamethazine.html","C12H14N4O2S","free base","Sulfadimidine,Sulfadimerazine","CC1=NC(=NC(=C1)C)N[S](=O)(=O)C2=CC=C(N)C=C2",0.878,4,2,3]
["S3140","Milnacipran HCl","g7","L4700-04","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.",282.81,"101152-94-7",{"v":57,"d":"57.00"},201.55,{"v":57,"d":"57.00"},201.55,"http://selleckchem.com/products/milnacipran-hydrochloride.html","C15H22N2O.HCl","HCl","N/A","Cl.CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2",{"v":1.67,"d":"1.670"},1,1,5]
["S3144","Darifenacin HBr","h7","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.",507.46,"133099-07-7",{"v":100,"d":"100.00"},197.06,"<1",null,"http://selleckchem.com/products/darifenacin-hydrobromide.html","C28H30N2O2.HBr","HBr","UK-88525","Br.NC(=O)C(C1CCN(CCC2=CC=C3OCCC3=C2)C1)(C4=CC=CC=C4)C5=CC=CC=C5",5.048,2,1,7]
["S3163","Benztropine mesylate","a8","L4700-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Benztropine(Cogentin mesylate, Benztropine methanesulfonate) is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.",403.53,"132-17-2",{"v":50,"d":"50.00"},123.91,{"v":81,"d":"81.00"},200.73,"http://selleckchem.com/products/benztropine-mesylate.html","C21H25NO.CH4SO3","Mesylate","Cogentin mesylate, Benztropine methanesulfonate","CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.C[S](O)(=O)=O",3.461,1,0,4]
["S3173","Antipyrine","b8","L4700-04","in 10mM DMSO","COX","Neuronal Signaling","Antipyrine (Phenazone,Phenazon) is an analgesic and antipyretic agent; selective COX-3 inhibitor.",188.23,"60-80-0",{"v":38,"d":"38.00"},201.88,{"v":38,"d":"38.00"},201.88,"http://selleckchem.com/products/antipyrine.html","C11H12N2O","free base","Phenazone,Phenazon","CN1N(C(=O)C=C1C)C2=CC=CC=C2",1.218,1,0,1]
["S3175","Atomoxetine HCl","c8","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.",291.82,"82248-59-7",{"v":58,"d":"58.00"},198.75,{"v":2,"d":"2.00"},6.85,"http://selleckchem.com/products/atomoxetine-hydrochloride.html","C17H21NO.HCl","HCl","LY 139603 HCl","Cl.CNCCC(OC1=CC=CC=C1C)C2=CC=CC=C2",3.959,1,1,6]
["S3180","Eletriptan HBr","d8","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Eletriptan (UK-116044) is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.",463.43,"177834-92-3",{"v":93,"d":"93.00"},200.68,"<1",null,"http://selleckchem.com/products/eletriptan-hydrobromide.html","C22H26N2O2S.HBr","HBr","UK-116044","Br.CN1CCCC1CC2=C[NH]C3=C2C=C(CC[S](=O)(=O)C4=CC=CC=C4)C=C3",4.929,2,1,6]
["S3183","Amitriptyline HCl","e8","L4700-04","in 10mM DMSO","5-HT Receptor,Histamine Receptor,Serotonin Transporter","Neuronal Signaling","Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).",313.86,"549-18-8",{"v":63,"d":"63.00"},200.73,{"v":15,"d":"15.00"},47.79,"http://selleckchem.com/products/amitriptyline-hydrochloride.html","C20H23N.HCl","HCl","N/A","Cl.CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C13",5.154,0,0,3]
["S3189","Ropinirole HCl","f8","L4700-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Ropinirole (SKF-101468A) a selective dopamine D2 receptors agonist with Ki of 29 nM.",296.84,"91374-20-8",{"v":10,"d":"10.00"},33.69,{"v":60,"d":"60.00"},202.13,"http://selleckchem.com/products/ropinirole-hydrochloride.html","C16H24N2O.HCl","HCl","SKF-101468A","Cl.CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2",3.341,1,1,7]
["S3196","Azacyclonol","g8","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.",267.37,"115-46-8",{"v":53,"d":"53.00"},198.23,{"v":2,"d":"2.00"},7.48,"http://selleckchem.com/products/azacyclonol.html","C18H21NO","free base","MER 17, MDL 4829","OC(C1CCNCC1)(C2=CC=CC=C2)C3=CC=CC=C3",2.846,0,1,3]
["S3200","Triflusal","h8","L4700-04","in 10mM DMSO","COX","Immunology & Inflammation","Triflusal (UR1501) irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.",248.16,"322-79-2",{"v":50,"d":"50.00"},201.48,"<1",null,"http://selleckchem.com/products/triflusal.html","C10H7F3O4","free base","UR1501","CC(=O)OC1=CC(=CC=C1C(O)=O)C(F)(F)F",2.169,3,0,4]
["S3201","Trifluoperazine 2HCl","a9","L4700-04","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).",480.42,"440-17-5",{"v":88,"d":"88.00"},183.17,{"v":96,"d":"96.00"},199.83,"http://selleckchem.com/products/trifluoperazine-dihydrochloride.html","C21H24F3N3S.2HCl","2HCl","SKF5019","Cl.Cl.CN1CCN(CCCN2C3=C(SC4=CC=C(C=C24)C(F)(F)F)C=CC=C3)CC1",5.739,0,0,5]
["S3603","Betulinic acid","c9","L4700-04","in 10mM DMSO","NF-κB,Topoisomerase","DNA Damage/DNA Repair","Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.",{"v":456.7,"d":"456.70"},"472-15-1",{"v":20,"d":"20.00"},43.79,"<1",null,"http://selleckchem.com/products/betulinic-acid.html","C30H48O3","free base","ALS-357, Lupatic acid, Betulic acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C(O)=O",6.546,1,1,2]
["S3639","Tacrine hydrochloride hydrate","d9","L4700-04","in 10mM DMSO","AChR,HNMT","Neuronal Signaling","Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.","198.26(free bases)","206658-92-6",{"v":50,"d":"50.00"},252.19,{"v":50,"d":"50.00"},252.19,"http://selleckchem.com/products/tacrine-hydrochloride-hydrate.html","C13H14N2.xHCl.xH2O","hydrochloride hydrate","Tacrine, Tetrahydroaminacrine, Tetrahydroaminoacridine","NC1=C2C=CC=CC2=NC3=C1CCCC3",4.258,1,1,0]
["S3655","Cefepime Dihydrochloride Monohydrate","e9","L4700-04","in 10mM DMSO","Bacterial","Microbiology","Cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intra-abdominal infections.",{"v":571.5,"d":"571.50"},"123171-59-5",{"v":100,"d":"100.00"},174.98,{"v":1,"d":"1.00"},1.75,"http://selleckchem.com/products/cefepime-dihydrochloride-monohydrate.html","C19H25N6O5S2.HCl.Cl.H2O","dihydrochloride hydrate","N/A","O.Cl.Cl.CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3(C)CCCC3)C4=CSC(=N4)N",-2.421,5,2,7]
["S3684","Methacholine chloride","f9","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Methacholine (Mecholyl, Acetyl-β-methylcholine) is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.",195.69,"62-51-1",{"v":39,"d":"39.00"},199.29,{"v":39,"d":"39.00"},199.29,"http://selleckchem.com/products/methacholine-chloride.html","C8H18NO2.Cl","chloride","Mecholyl chloride, Acetyl-β-methylcholine chloride","[Cl-].CC(C[N+](C)(C)C)OC(C)=O",-3.492,2,0,4]
["S3698","Nortriptyline hydrochloride","g9","L4700-04","in 10mM DMSO","Autophagy","Autophagy","Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.",299.84,"894-71-3",{"v":59,"d":"59.00"},196.77,{"v":59,"d":"59.00"},196.77,"http://selleckchem.com/products/nortriptyline-hydrochloride.html","C19H21N.HCl","hydrochloride","Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride","Cl.CNCCC=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.618,0,1,3]
["S3701","Benactyzine hydrochloride","h9","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.",363.88,"57-37-4",{"v":72,"d":"72.00"},197.87,{"v":72,"d":"72.00"},197.87,"http://selleckchem.com/products/benactyzine-hydrochloride.html","C20H25NO3.HCl","hydrochloride","N/A","Cl.CCN(CC)CCOC(=O)C(O)(C1=CC=CC=C1)C2=CC=CC=C2",3.832,2,0,9]
["S3706","Sarpogrelate hydrochloride","a10","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Sarpogrelate (MCI-9042) is a selective 5-HT2A antagonist with pKi values of 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively.",465.97,"135159-51-2",{"v":93,"d":"93.00"},199.58,{"v":93,"d":"93.00"},199.58,"http://selleckchem.com/products/sarpogrelate-hydrochloride.html","C24H31NO6.HCl","hydrochloride","MCI-9042","Cl.COC1=CC=CC(=C1)CCC2=C(OCC(CN(C)C)OC(=O)CCC(O)=O)C=CC=C2",1.427,5,0,14]
["S3713","Moxidectin","b10","L4700-04","in 10mM DMSO","Parasite","Microbiology","Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.",639.82,"113507-06-5",{"v":100,"d":"100.00"},156.29,"<1",null,"http://selleckchem.com/products/moxidectin.html","C37H53NO8","free base","Milbemycin B","CO\\N=C1/CC2(CC3CC(C\\C=C(C)\\CC(C)/C=C/C=C/4COC5C(O)C(=CC(C(=O)O3)C45O)C)O2)OC(C1C)\\C(C)=C\\C(C)C",5.026,7,1,3]
["S3716","Flibanserin","c10","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Flibanserin (BIMT-17, BIMT-17-BS) is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors.",{"v":390.4,"d":"390.40"},"167933-07-5",{"v":78,"d":"78.00"},{"v":199.8,"d":"199.80"},"<1",null,"http://selleckchem.com/products/flibanserin.html","C20H21F3N4O","free base","BIMT-17, BIMT-17-BS","FC(F)(F)C1=CC=CC(=C1)N2CCN(CC2)CCN3C(=O)NC4=C3C=CC=C4",3.609,1,1,5]
["S3723","Ramosetron Hydrochloride","d10","L4700-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ramosetron Hydrochloride (YM-060) is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity.",{"v":315.8,"d":"315.80"},"132907-72-3",{"v":63,"d":"63.00"},199.49,{"v":63,"d":"63.00"},199.49,"http://selleckchem.com/products/ramosetron-hydrochloride.html","C17H17N3O.HCl","hydrochloride","YM-060","Cl.C[N]1C=C(C(=O)C2CCC3=C(C2)[NH]C=N3)C4=C1C=CC=C4",2.948,2,1,2]
["S3730","Metaxalone","e10","L4700-04","in 10mM DMSO","Others","Others","Metaxalone (Skelaxin, Methaxalonum, Zorane) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.",221.25,"1665-48-1",{"v":44,"d":"44.00"},198.87,"<1",null,"http://selleckchem.com/products/metaxalone.html","C12H15NO3","free base","Skelaxin, Methaxalonum, Zorane","CC1=CC(=CC(=C1)C)OCC2CNC(=O)O2",2.468,3,1,3]
["S3735","Umeclidinium bromide","f10","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).",508.49,"869113-09-7",{"v":100,"d":"100.00"},196.66,"<1",null,"http://selleckchem.com/products/umeclidinium-bromide.html","C29H34NO2.Br","bromide","GSK573719A","[Br-].OC(C1=CC=CC=C1)(C2=CC=CC=C2)C34CC[N+](CCOCC5=CC=CC=C5)(CC3)CC4",0.924,1,0,8]
["S3765","Picroside II","g10","L4700-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.",512.46,"39012-20-9",{"v":100,"d":"100.00"},195.14,null,null,"http://selleckchem.com/products/picroside-ii.html","C23H28O13","free base","6-Vanilloylcatalpol, Vanilloyl catalpol","COC1=CC(=CC=C1O)C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C5(CO)OC25",-1.796,7,6,8]
["S3769","Palmatine","h10","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.",{"v":352.4,"d":"352.40"},"3486-67-7",{"v":70,"d":"70.00"},198.64,null,null,"http://selleckchem.com/products/palmatine.html","C21H22NO4","free base","Berbericinine, Burasaine","COC1=CC2=C(C=C1OC)C3=CC4=C(C=[N+]3CC2)C(=C(OC)C=C4)OC",4.161,4,0,4]
["S3786","Glabridin","a11","L4700-04","in 10mM DMSO","GABA Receptor,PPAR","Metabolism","Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.",324.37,"59870-68-7",{"v":64,"d":"64.00"},197.31,null,null,"http://selleckchem.com/products/glabridin.html","C20H20O4","free base","Q-100692, KB-289522, LS-176045","CC1(C)OC2=C(C=C1)C3=C(CC(CO3)C4=CC=C(O)C=C4O)C=C2",3.999,2,2,1]
["S3788","Carvacrol","b11","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.",150.22,"499-75-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/carvacrol.html","C10H14O","free base","cymophenol","CC(C)C1=CC=C(C)C(=C1)O",3.268,0,1,1]
["S3816","Dehydroevodiamine","c11","L4700-04","in 10mM DMSO","COX,NF-κB,PGES,ROS","Immunology & Inflammation","Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.",301.34,"67909-49-3",{"v":19,"d":"19.00"},63.05,null,null,"http://selleckchem.com/products/dehydroevodiamine.html","C19H15N3O","inner salt","DHED","C[N+]1=C2N(CCC3=C2[N-]C4=C3C=CC=C4)C(=O)C5=C1C=CC=C5",3.186,1,0,0]
["S3817","Harmine hydrochloride","d11","L4700-04","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,DYRK,MAO","Cell Cycle","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",248.71,"343-27-1",{"v":21,"d":"21.00"},84.44,null,null,"http://selleckchem.com/products/harmine-hydrochloride.html","C13H12N2O.HCl","hydrochloride","Telepathine hydrochloride","Cl.COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",{"v":2.82,"d":"2.820"},2,1,1]
["S3820","Dehydroevodiamine hydrochloride","e11","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.",{"v":337.8,"d":"337.80"},"111664-82-5",{"v":37,"d":"37.00"},109.53,null,null,"http://selleckchem.com/products/dehydroevodiamine-hydrochloride.html","C19H15N3O.HCl","hydrochloride","N/A","Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13",2.891,2,0,0]
["S3835","Loganin","f11","L4700-04","in 10mM DMSO","AChR,BACE,BChE","Neuronal Signaling","Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.",390.38,"18524-94-2",{"v":78,"d":"78.00"},199.81,null,null,"http://selleckchem.com/products/loganin.html","C17H26O10","free base","Loganoside","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)C(O)CC13",-1.895,5,5,5]
["S3866","Galanthamine","g11","L4700-04","in 10mM DMSO","AChR","Neuronal Signaling","Galanthamine (Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.",287.35,"357-70-0",{"v":100,"d":"100.00"},348.01,{"v":57,"d":"57.00"},198.36,"http://selleckchem.com/products/galanthamine.html","C17H21NO3","free base","Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine","COC1=C2OC3CC(O)C=CC34CCN(C)CC(=C24)C=C1",1.442,2,1,1]
["S3868","Harmine","h11","L4700-04","in 10mM DMSO","MAO,PPAR","Metabolism","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",212.25,"442-51-3",{"v":42,"d":"42.00"},197.88,null,null,"http://selleckchem.com/products/harmine.html","C13H12N2O","free base","Telepathine","COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",2.438,2,1,1]
["S3872","Guaiacol","a2","L4700-05","in 10mM DMSO","COX,NF-κB","NF-κB","Guaiacol (O-methoxyphenol, 2-hydroxyanisole, O-methylcatechol) is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin. Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity.",124.14,"90-05-1",{"v":24,"d":"24.00"},193.33,null,null,"http://selleckchem.com/products/guaiacol.html","C7H8O2","free base","o-methoxyphenol, 2-hydroxyanisole, O-methylcatechol","COC1=C(O)C=CC=C1",1.571,1,1,1]
["S3884","Jatrorrhizine","b2","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.",338.38,"3621-38-3",{"v":67,"d":"67.00"},{"v":198,"d":"198.00"},null,null,"http://selleckchem.com/products/jatrorrhizine.html","C20H20NO4","free base","Neprotin, Yatrorizine","COC1=CC2=C(CC[N+]3=CC4=C(C=CC(=C4OC)OC)C=C23)C=C1O",3.936,3,1,3]
["S3899","Hederagenin","c2","L4700-05","in 10mM DMSO","COX,NF-κB,NOS","Immunology & Inflammation","Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB.",{"v":472.7,"d":"472.70"},"465-99-6",{"v":94,"d":"94.00"},198.86,null,null,"http://selleckchem.com/products/hederagenin.html","C30H48O4","free base","Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1)C(O)=O",5.356,1,2,2]
["S3903","Lycorine","d2","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.",287.31,"476-28-8",{"v":57,"d":"57.00"},198.39,null,null,"http://selleckchem.com/products/lycorine.html","C16H17NO4","free base","Galanthidine, Amarylline, Narcissine, Licorine, Belamarine","OC1C=C2CCN3CC4=CC5=C(OCO5)C=C4C(C1O)C23",0.713,2,2,0]
["S3904","Isoimperatorin","e2","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities.  Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.",270.28,"482-45-1",{"v":54,"d":"54.00"},199.79,null,null,"http://selleckchem.com/products/isoimperatorin.html","C16H14O4","free base","N/A","CC(C)=CCOC1=C2C=COC2=CC3=C1C=CC(=O)O3",3.652,4,0,3]
["S3925","(-)-Epicatechin gallate","f2","L4700-05","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,null,null,"http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3931","Ginsenoside Rd","g2","L4700-05","in 10mM DMSO","Calcium Channel,COX,NF-κB,NOS,P450 (e.g. CYP17)","Immunology & Inflammation","Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.",947.15,"52705-93-8",{"v":90,"d":"90.00"},95.02,null,null,"http://selleckchem.com/products/ginsenoside-rd.html","C48H82O18","free base","Panaxoside Rd, Sanchinoside Rd","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C(C)(C)C5CCC34C",0.548,6,12,13]
["S3944","Valproic acid (VPA)","h2","L4700-05","in 10mM DMSO","Autophagy,HDAC,Mitophagy,Notch,PGC-1α","Epigenetics","Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.",144.21,"99-66-1","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/valproic-acid.html","C8H16O2","free base","2-Propylvaleric Acid, Valproate","CCCC(CCC)C(O)=O",2.749,1,0,5]
["S3945","L-Cycloserine","a3","L4700-05","in 10mM DMSO","Transferase","Metabolism","L-Cycloserine (Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.",102.09,"339-72-0",{"v":8,"d":"8.00"},78.36,{"v":20,"d":"20.00"},195.91,"http://selleckchem.com/products/l-cycloserine.html","C3H6N2O2","free base","Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine","NC1CONC1=O",-1.788,2,2,0]
["S3960","Higenamine hydrochloride","b3","L4700-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.",307.77,"11041-94-4",{"v":61,"d":"61.00"},{"v":198.2,"d":"198.20"},null,null,"http://selleckchem.com/products/higenamine-hydrochloride.html","C16H17NO3.HCl","hydrochloride","Norcoclaurine HCl, (+-)-Demethylcoclaurine hydrochloride","Cl.OC1=CC=C(CC2NCCC3=CC(=C(O)C=C23)O)C=C1",3.031,0,4,2]
["S3969","Veratric acid","c3","L4700-05","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,PGES","Immunology & Inflammation","Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.",182.17,"93-07-2",{"v":36,"d":"36.00"},197.62,null,null,"http://selleckchem.com/products/veratric-acid.html","C9H10O4","free base","3,4-Dimethoxybenzoic acid","COC1=C(OC)C=C(C=C1)C(O)=O",1.426,3,0,3]
["S3974","(+)-Catechin hydrate","d3","L4700-05","in 10mM DMSO","COX","Immunology & Inflammation","(+)-Catechin hydrate is a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.  (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.",290.27,"225937-10-0",{"v":58,"d":"58.00"},199.81,null,null,"http://selleckchem.com/products/catechin-hydrate.html","C15H14O6.xH2O","hydrate","N/A","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4011","Ampiroxicam","e3","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.",447.46,"99464-64-9",{"v":90,"d":"90.00"},201.14,"<1",null,"http://selleckchem.com/products/ampiroxicam.html","C20H21N3O7S","free base","CP 65703","CCOC(=O)OC(C)OC1=C(N(C)[S](=O)(=O)C2=C1C=CC=C2)C(=O)NC3=NC=CC=C3",1.718,8,1,8]
["S4014","Hyoscyamine","f3","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.",289.37,"101-31-5",{"v":58,"d":"58.00"},200.44,"<1",null,"http://selleckchem.com/products/hyoscyamine-daturine.html","C17H23NO3","free base","Daturine","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",1.721,2,1,5]
["S4021","Tolcapone","g3","L4700-05","in 10mM DMSO","COMT,Histone Methyltransferase,Transferase","Metabolism","Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.",273.24,"134308-13-7",{"v":55,"d":"55.00"},201.29,"<1",null,"http://selleckchem.com/products/tolcapone.html","C14H11NO5","free base","Ro 40-7592","CC1=CC=C(C=C1)C(=O)C2=CC(=C(O)C(=C2)[N+]([O-])=O)O",{"v":3.13,"d":"3.130"},1,2,3]
["S4022","Probenecid","h3","L4700-05","in 10mM DMSO","Taste Receptor,TRP Channel","Transmembrane Transporters","Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.",285.36,"57-66-9",{"v":57,"d":"57.00"},199.75,"<1",null,"http://selleckchem.com/products/probenecid-benemid.html","C13H19NO4S","free base","Benemid","CCCN(CCC)[S](=O)(=O)C1=CC=C(C=C1)C(O)=O",2.321,3,0,7]
["S4023","Procaine HCl","a4","L4700-05","in 10mM DMSO","AChR,NMDAR,Sodium Channel","Transmembrane Transporters","Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.",272.77,"51-05-8",{"v":55,"d":"55.00"},201.64,{"v":55,"d":"55.00"},201.64,"http://selleckchem.com/products/procaine-novocaine-hcl.html","C13H20N2O2.HCl","HCl","Novocaine HCl","Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1",2.157,2,1,7]
["S4024","Homatropine Methylbromide","b4","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.",370.28,"80-49-9",{"v":74,"d":"74.00"},199.85,{"v":74,"d":"74.00"},199.85,"http://selleckchem.com/products/homatropine-methylbromide.html","C17H24NO3.Br","quaternary-N bromide salt","N/A","[Br-].C[N+]1(C)C2CCC1CC(C2)OC(=O)C(O)C3=CC=CC=C3",-2.076,2,1,4]
["S4025","Homatropine Bromide","c4","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.",356.25,"51-56-9",{"v":71,"d":"71.00"},{"v":199.3,"d":"199.30"},{"v":71,"d":"71.00"},{"v":199.3,"d":"199.30"},"http://selleckchem.com/products/homatropine-bromide.html","C16H21NO3.HBr","quaternary-N bromide salt","N/A","Br.CN1C2CCC1CC(C2)OC(=O)C(O)C3=CC=CC=C3",2.188,2,1,4]
["S4026","Hydroxyzine 2HCl","d4","L4700-05","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.",447.83,"2192-20-3",{"v":90,"d":"90.00"},200.97,{"v":90,"d":"90.00"},200.97,"http://selleckchem.com/products/hydroxyzine-2hcl.html","C21H27ClN2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",4.231,1,1,8]
["S4031","Aclidinium Bromide","e4","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Aclidinium Bromide (LAS 34273, LAS-W 330) inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.",564.55,"320345-99-1",{"v":113,"d":"113.00"},200.16,"<1",null,"http://selleckchem.com/products/aclidinium-bromide.html","C26H30NO4S2.Br","quaternary-N bromide salt","LAS 34273, LAS-W 330","[Br-].OC(C(=O)OC1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)(C4=CC=CS4)C5=CC=CS5",0.979,3,0,10]
["S4034","Diphemanil Methylsulfate","f4","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).",389.51,"62-97-5",{"v":25,"d":"25.00"},64.18,{"v":28,"d":"28.00"},71.89,"http://selleckchem.com/products/diphemanil-methylsulfate.html","C20H24N.CH3O4S","Methylsulfate","N/A","CO[S]([O-])(=O)=O.C[N+]1(C)CC[C](CC1)=[C](C2=CC=CC=C2)C3=CC=CC=C3",0.038,1,0,3]
["S4049","Valdecoxib","g4","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.",314.36,"181695-72-7",{"v":63,"d":"63.00"},200.41,"<1",null,"http://selleckchem.com/products/valdecoxib.html","C16H14N2O3S","free base","N/A","CC1=C(C2=CC=C(C=C2)[S](N)(=O)=O)C(=NO1)C3=CC=CC=C3",{"v":2.6,"d":"2.600"},4,1,3]
["S4051","Nabumetone","h4","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.",228.29,"42924-53-8",{"v":46,"d":"46.00"},{"v":201.5,"d":"201.50"},"<1",null,"http://selleckchem.com/products/nabumetone.html","C15H16O2","free base","BRL-14777","COC1=CC=C2C=C(CCC(C)=O)C=CC2=C1",2.943,2,0,4]
["S4053","Sertraline HCl","a5","L4700-05","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.",342.69,"79559-97-0",{"v":69,"d":"69.00"},201.35,"<1",null,"http://selleckchem.com/products/sertraline-hcl.html","C17H17Cl2N.HCl","HCl","CP-51974-1 HCl","Cl.CNC1CCC(C2=CC=C(Cl)C(=C2)Cl)C3=C1C=CC=C3",5.378,0,1,2]
["S4061","Levobupivacaine HCl","b5","L4700-05","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Levobupivacaine HCl ((S)-(-)-Bupivacaine), the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.",324.89,"27262-48-2",{"v":64,"d":"64.00"},196.99,{"v":64,"d":"64.00"},196.99,"http://selleckchem.com/products/lvobupivacaine-hcl.html","C18H28N2O.HCl","Hydrochloride","(S)-(-)-Bupivacaine HCl","Cl.CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.692,1,1,5]
["S4064","Escitalopram Oxalate","c5","L4700-05","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.",414.43,"219861-08-2",{"v":83,"d":"83.00"},200.28,{"v":25,"d":"25.00"},60.32,"http://selleckchem.com/products/escitalopram-oxalate.html","C20H21FN2O.C2H2O4","Oxalate","N/A","CN(C)CCCC1(OCC2=CC(=CC=C12)C#N)C3=CC=C(F)C=C3.OC(=O)C(O)=O",0.257,3,0,6]
["S4072","Decamethonium Bromide","d5","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.",418.29,"541-22-0",{"v":34,"d":"34.00"},81.28,{"v":84,"d":"84.00"},200.82,"http://selleckchem.com/products/decamethonium-bromide.html","C16H38N2.2Br","Bromide","N/A","[Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C",-3.707,0,0,11]
["S4076","Propranolol HCl","e5","L4700-05","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.",{"v":295.8,"d":"295.80"},"318-98-9",{"v":59,"d":"59.00"},199.46,{"v":6,"d":"6.00"},20.28,"http://selleckchem.com/products/propranolol-hcl.html","C16H21NO2.HCl","Hydrochloride","AY-64043, ICI-45520, NCS-91523","Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12",2.922,1,2,6]
["S4078","Mefenamic Acid","f5","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.",241.29,"61-68-7",{"v":48,"d":"48.00"},198.93,"<1",null,"http://selleckchem.com/products/mefenamic-acid.html","C15H15NO2","free base","CI 473, CN-35355","CC1=C(C)C(=CC=C1)NC2=CC=CC=C2C(O)=O",3.982,1,1,3]
["S4086","Loxapine Succinate","g5","L4700-05","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Loxapine Succinate(NSC 759578) is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.",{"v":445.9,"d":"445.90"},"27833-64-3",{"v":89,"d":"89.00"},{"v":199.6,"d":"199.60"},"<1",null,"http://selleckchem.com/products/loxapine-succinate.html","C18H18ClN3O.C4H6O4","Succinate","NSC 759578","CN1CCN(CC1)C2=NC3=C(OC4=C2C=C(Cl)C=C4)C=CC=C3.OC(=O)CCC(O)=O",0.039,4,0,4]
["S4096","Droperidol","h5","L4700-05","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system.",379.43,"548-73-2",{"v":76,"d":"76.00"},{"v":200.3,"d":"200.30"},"<1",null,"http://selleckchem.com/products/droperidol.html","C22H22FN3O2","free base","NSC 169874,Dehydrobenzperidol","FC1=CC=C(C=C1)C(=O)CCCN2CCC(=CC2)N3C(=O)NC4=C3C=CC=C4",3.049,2,1,6]
["S4112","Desvenlafaxine Succinate hydrate","a6","L4700-05","in 10mM DMSO","Adrenergic Receptor,Serotonin Transporter","Neuronal Signaling","Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.",399.48,"386750-22-7",{"v":80,"d":"80.00"},191.22,"<1",null,"http://selleckchem.com/products/desvenlafaxine-succinate.html","C16H25NO2.C4H6O4.H2O","Succinate hydrate","WY 45233  Succinate","O.CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2.OC(=O)CCC(O)=O",-0.598,2,1,7]
["S4113","Desvenlafaxine","b6","L4700-05","in 10mM DMSO","Adrenergic Receptor,Serotonin Transporter","Neuronal Signaling","Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.",263.38,"93413-62-8",{"v":37,"d":"37.00"},140.48,"<1",null,"http://selleckchem.com/products/desvenlafaxine.html","C16H25NO2","Free Base","WY 45233  Succinate","CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2",2.796,0,1,4]
["S4125","Sodium Phenylbutyrate","c6","L4700-05","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.",187.19,"1716-12-7",{"v":8,"d":"8.00"},42.97,{"v":30,"d":"30.00"},161.13,"http://selleckchem.com/products/sodium-phenylbutyrate.html","C10H11O2.Na","Sodium Salt","4-PBA, 4-Phenylbutyric acid, NaPB","[Na]OC(=O)CCCC1=CC=CC=C1",2.497,2,0,5]
["S4136","Carprofen","d6","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Carprofen inhibits canine COX2 with IC50 of 30 nM.",273.71,"53716-49-7",{"v":55,"d":"55.00"},200.94,"<1",null,"http://selleckchem.com/products/carprofen.html","C15H12ClNO2","free base","N/A","CC(C(O)=O)C1=CC2=C(C=C1)C3=C([NH]2)C=CC(=C3)Cl",4.114,1,1,2]
["S4143","Pentoxyverine Citrate","e6","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Pentoxyverine Citrate (Carbetapentane) is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.",525.59,"23142-01-0",{"v":100,"d":"100.00"},190.26,{"v":100,"d":"100.00"},190.26,"http://selleckchem.com/products/pentoxyverine-carbetapentane-citrate.html","C20H31NO3.C6H8O7","Citrate","Carbetapentane Citrate","CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=N2)C(C)C.O[P](O)(O)=O",2.949,2,1,8]
["S4149","Amfenac Sodium Monohydrate","f6","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.",295.27,"61618-27-7",{"v":59,"d":"59.00"},199.82,{"v":59,"d":"59.00"},199.82,"http://selleckchem.com/products/amfenac-sodium-monohydrate.html","C15H12NO3.H2O.Na","free base","N/A","O.[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=CC=C2",{"v":0.47,"d":"0.470"},1,1,4]
["S4155","Chlorzoxazone","g6","L4700-05","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.",169.57,"95-25-0",{"v":34,"d":"34.00"},200.51,"<1",null,"http://selleckchem.com/products/chlorzoxazone.html","C7H4ClNO2","free base","Chlorzoxazon,Paraflex","ClC1=CC2=C(OC(=O)N2)C=C1",2.004,2,1,0]
["S4162","Benzethonium Chloride","h6","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.",448.08,"121-54-0",{"v":90,"d":"90.00"},200.86,{"v":90,"d":"90.00"},200.86,"http://selleckchem.com/products/benzethonium-chloride.html","C27H42NO2.Cl","Chloride","N/A","[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1",2.147,2,0,12]
["S4171","Choline Chloride","a7","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Choline chloride(Hepacholine) is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.",139.62,"67-48-1",{"v":28,"d":"28.00"},200.54,{"v":28,"d":"28.00"},200.54,"http://selleckchem.com/products/choline-chloride.html","C5H14NO.Cl","Chloride","Hepacholine","[Cl-].C[N+](C)(C)CCO",-4.248,0,1,2]
["S4176","Trometamol","b7","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Trometamol(Tromethamine) is a proton acceptor used to treat acidemia.",121.14,"77-86-1",{"v":2,"d":"2.00"},16.51,{"v":24,"d":"24.00"},198.12,"http://selleckchem.com/products/trometamol.html","C4H11NO3","free base","Tromethamine","NC(CO)(CO)CO",-2.381,0,4,3]
["S4179","Mezlocillin Sodium","c7","L4700-05","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.",561.56,"42057-22-7",{"v":100,"d":"100.00"},178.08,{"v":100,"d":"100.00"},178.08,"http://selleckchem.com/products/mezlocillin-sodium.html","C21H25N5O8S2.Na","Sodium Salt","N/A","[Na+].CC1(C)SC2C(NC(=O)C(NC(=O)N3CCN(C3=O)[S](C)(=O)=O)C4=CC=CC=C4)C(=O)N2C1C([O-])=O",{"v":-1.69,"d":"-1.690"},6,2,6]
["S4181","Nicardipine HCl","d7","L4700-05","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.",515.99,"54527-84-3",{"v":100,"d":"100.00"},{"v":193.8,"d":"193.80"},"<1",null,"http://selleckchem.com/products/nicardipine-hcl.html","C26H29N3O6.HCl","Hydrochloride","RS-69216,YC-93","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",{"v":3.87,"d":"3.870"},4,1,11]
["S4188","Sasapyrine","e7","L4700-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.",258.23,"552-94-3",{"v":52,"d":"52.00"},201.37,"<1",null,"http://selleckchem.com/products/sasapyrine.html","C14H10O5","free base","NSC-49171,Salsalate","OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O",2.649,3,1,4]
["S4190","Cinchophen","f7","L4700-05","in 10mM DMSO","Others","Others","Cinchophen(Cinconal) is an analgesic drug that is frequently used to treat gout.",249.26,"132-60-5",{"v":50,"d":"50.00"},200.59,"<1",null,"http://selleckchem.com/products/cinchophen.html","C16H11NO2","free base","Cinconal","OC(=O)C1=C2C=CC=CC2=NC(=C1)C3=CC=CC=C3",3.593,2,0,2]
["S4219","Azaperone","g7","L4700-05","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.",{"v":327.4,"d":"327.40"},"1649-18-9",{"v":65,"d":"65.00"},198.53,"<1",null,"http://selleckchem.com/products/azaperone.html","C19H22FN3O","free base","NSC 170976","FC1=CC=C(C=C1)C(=O)CCCN2CCN(CC2)C3=CC=CC=N3",3.368,2,0,6]
["S4222","Piperacillin Sodium","h7","L4700-05","in 10mM DMSO","Antibiotics","Microbiology","Piperacillin (CL227193,Pipracil) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.",539.54,"59703-84-3",{"v":100,"d":"100.00"},185.34,{"v":100,"d":"100.00"},185.34,"http://selleckchem.com/products/piperacillin-sodium.html","C23H27N5O7S.Na","Sodium Salt","CL227193,Pipracil","[Na+].CCN1CCN(C(=O)NC(C(=O)NC2C3SC(C)(C)C(N3C2=O)C([O-])=O)C4=CC=CC=C4)C(=O)C1=O",-1.558,5,2,6]
["S4230","Oxaprozin","a8","L4700-05","in 10mM DMSO","COX","Metabolism","Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.",293.32,"21256-18-8",{"v":59,"d":"59.00"},201.15,"<1",null,"http://selleckchem.com/products/oxaprozin.html","C18H15NO3","free base","WY-21743,nsc 310839","OC(=O)CCC1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3",{"v":3.59,"d":"3.590"},3,0,5]
["S4231","Pilocarpine HCl","b8","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.",244.72,"54-71-7",{"v":48,"d":"48.00"},196.14,{"v":48,"d":"48.00"},196.14,"http://selleckchem.com/products/pilocarpine-hcl.html","C11H16N2O2.HCl","Hydrochloride","NSC 5746 HCl","Cl.CCC1C(COC1=O)CC2=CN=C[N]2C",1.347,3,0,3]
["S4240","Doxylamine Succinate","c8","L4700-05","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.",388.46,"562-10-7",{"v":78,"d":"78.00"},200.79,{"v":78,"d":"78.00"},200.79,"http://selleckchem.com/products/doxylamine-succinate.html","C17H22N2O.C4H6O4","Succinate","N/A","CN(C)CCOC(C)(C1=CC=CC=C1)C2=CC=CC=N2.OC(=O)CCC(O)=O",-0.527,4,0,9]
["S4244","Serotonin HCl","d8","L4700-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.",212.68,"153-98-0",{"v":42,"d":"42.00"},197.48,{"v":42,"d":"42.00"},197.48,"http://selleckchem.com/products/serotonin-hcl.html","C10H12N2O.HCl","Hydrochloride","5-HT HCl","Cl.NCCC1=C[NH]C2=CC=C(O)C=C12",{"v":1.69,"d":"1.690"},0,3,2]
["S4247","Prucalopride Succinate","e8","L4700-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Prucalopride(R-108512) is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively.",485.96,"179474-85-2",{"v":97,"d":"97.00"},{"v":199.6,"d":"199.60"},{"v":97,"d":"97.00"},{"v":199.6,"d":"199.60"},"http://selleckchem.com/products/prucalopride-succinat.html","C18H26ClN3O3.C4H6O4","Succinat","R-108512","COCCCN1CCC(CC1)NC(=O)C2=C3OCCC3=C(N)C(=C2)Cl.OC(=O)CCC(O)=O",-2.338,5,2,9]
["S4248","Bromfenac Sodium","f8","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Bromfenac Sodium (AHR 10282R,Bromsite,Bromday,Prolensa,Xibrom) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.",356.15,"91714-93-1",{"v":71,"d":"71.00"},199.35,{"v":71,"d":"71.00"},199.35,"http://selleckchem.com/products/bromfenac-sodium.html","C15H11BrNO3.Na","Sodium Salt","AHR 10282R,Bromsite,Bromday,Prolensa,Xibrom","[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=C(Br)C=C2",1.426,1,1,4]
["S4249","Flopropione","g8","L4700-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist.",182.17,"2295-58-1",{"v":36,"d":"36.00"},197.62,"<1",null,"http://selleckchem.com/products/flopropione.html","C9H10O4","free base","N/A","CCC(=O)C1=C(O)C=C(O)C=C1O",{"v":1.51,"d":"1.510"},1,3,2]
["S4250","Sulfamethoxypyridazine","h8","L4700-05","in 10mM DMSO","Anti-infection","Microbiology","Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.",{"v":280.3,"d":"280.30"},"80-35-3",{"v":56,"d":"56.00"},199.79,"<1",null,"http://selleckchem.com/products/sulfamethoxypyridazine.html","C11H12N4O3S","free base","CL 13494","COC1=NN=C(N[S](=O)(=O)C2=CC=C(N)C=C2)C=C1",1.014,5,2,4]
["S4256","Buspirone HCl","a9","L4700-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.",421.96,"33386-08-2",{"v":84,"d":"84.00"},199.07,{"v":84,"d":"84.00"},199.07,"http://selleckchem.com/products/buspirone-hcl.html","C21H31N5O2.HCl","Hydrochloride","Buspirone hydrochloride","Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)C4=NC=CC=N4",2.403,4,0,6]
["S4259","Vilazodone HCl","b9","L4700-05","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and  a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.",477.99,"163521-08-2",{"v":96,"d":"96.00"},200.84,"<1",null,"http://selleckchem.com/products/vilazodone-hcl.html","C26H27N5O2.HCl","Hydrochloride","EMD68843,SB659746A","Cl.NC(=O)C1=CC2=C(O1)C=CC(=C2)N3CCN(CCCCC4=C[NH]C5=C4C=C(C=C5)C#N)CC3",4.918,2,2,7]
["S4269","Vinorelbine ditartrate (KW-2307)","c9","L4700-05","in 10mM DMSO","Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.",1079.11,"125317-39-7",{"v":100,"d":"100.00"},92.67,{"v":100,"d":"100.00"},92.67,"http://selleckchem.com/products/vinorelbine-tartrate.html","C45H54N4O8.2C4H6O6","ditartrate","Nor-5'-anhydrovinblastine ditartrate,KW-2307","CCC1=CC2CN(C1)CC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC.OC(C(O)C(O)=O)C(O)=O.OC(C(O)C(O)=O)C(O)=O",{"v":-4,"d":"-4.000"},11,5,16]
["S4274","Rotigotine","d9","L4700-05","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.",315.47,"99755-59-6",{"v":63,"d":"63.00"},{"v":199.7,"d":"199.70"},"<1",null,"http://selleckchem.com/products/rotigotine.html","C19H25NOS","free base","N-0923","CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O",4.986,0,1,6]
["S4283","Cyclobenzaprine HCl","e9","L4700-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cyclobenzaprine HCl(Cyclobenzaprine hydrochloride) is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms; A 5-HT2 receptor antagonist.",311.85,"6202-23-9",{"v":62,"d":"62.00"},198.81,{"v":62,"d":"62.00"},198.81,"http://selleckchem.com/products/cyclobenzaprine-hci.html","C20H22ClN","Hydrochloride","Cyclobenzaprine hydrochloride","Cl.CN(C)CCC=C1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",4.709,0,0,3]
["S4288","Chloroambucil","f9","L4700-05","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.",304.21,"305-03-3",{"v":60,"d":"60.00"},197.23,"<1",null,"http://selleckchem.com/products/chloroambucil.html","C14H19Cl2NO2","free base","Chlorambucil,CB-1348,WR-139013","OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl",3.899,1,0,9]
["S4292","Diphenidol HCl","g9","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Diphenidol HCl(Diphenidol hydrochloride) is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.",345.91,"3254-89-5",{"v":69,"d":"69.00"},199.47,{"v":13,"d":"13.00"},37.58,"http://selleckchem.com/products/diphenidol-hcl.html","C21H28ClNO","Hydrochloride","Diphenidol hydrochloride","Cl.OC(CCCN1CCCCC1)(C2=CC=CC=C2)C3=CC=CC=C3",4.774,0,0,6]
["S4295","Meclofenamate Sodium","h9","L4700-05","in 10mM DMSO","COX,FTO","Neuronal Signaling","Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.",318.13,"6385-02-0",{"v":63,"d":"63.00"},198.03,{"v":63,"d":"63.00"},198.03,"http://selleckchem.com/products/meclofenamate-sodium.html","C14H11Cl2NO2.Na","Sodium Salt","CI 583","CC1=C(Cl)C(=C(Cl)C=C1)NC2=CC=CC=C2C(=O)O[Na]",4.915,2,1,4]
["S4357","Tacrine HCl","a10","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.",234.72,"1684-40-8",{"v":46,"d":"46.00"},195.98,{"v":46,"d":"46.00"},195.98,"http://www.selleckchem.com/products/tacrine-hcl.html","C13H14N2.HCl","hydrochlorid","N/A","Cl.NC1=C2C=CC=CC2=NC3=C1CCCC3",3.172,1,1,0]
["S4377","Imipramine HCl","b10","L4700-05","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).",316.87,"113-52-0",{"v":63,"d":"63.00"},198.82,{"v":63,"d":"63.00"},198.82,"http://www.selleckchem.com/products/imipramine-hcl.html","C19H25ClN2","hydrochloride","Melipramine HCl,G 22355","Cl.CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.769,0,0,4]
["S4385","Fosfomycin Tromethamine","c10","L4700-05","in 10mM DMSO","Others","Others","Fosfomycin tromethamine is a phosphonic acid bactericidal agent with in vitro activity against most urinary tract pathogens.",259.19,"78964-85-9",{"v":51,"d":"51.00"},196.77,{"v":51,"d":"51.00"},196.77,"http://www.selleckchem.com/products/fosfomycin-tromethamine.html","C7H18NO7P","tromethamine","Phosphomycin Tromethamine, Phosphonomycin Tromethamine","CC1OC1[P](O)(O)=O.NC(CO)(CO)CO",-2.699,1,4,4]
["S4389","Bephenium Hydroxynaphthoate","d10","L4700-05","in 10mM DMSO","AChR,Parasite","Neuronal Signaling","Bephenium(NSC 759245) is an activator of B-type Acetylcholine receptor (AChR). Bephenium selectively activates the Hco-L-AChR1 subtype made of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, Hco-ACR-8 subunits. Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.",443.53,"3818-50-6",{"v":88,"d":"88.00"},198.41,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/bephenium-hydroxynaphthoate.html","C28H29NO4","hydroxynaphthoa","NSC 759245","C[N+](C)(CCOC1=CC=CC=C1)CC2=CC=CC=C2.OC3=C(C=C4C=CC=CC4=C3)C([O-])=O",2.833,1,1,7]
["S4402","Oxeladin Citrate","e10","L4700-05","in 10mM DMSO","Others","Others","Oxeladin citrate (OL), a cough suppressant, is a highly potent and effective drug applied in the treatment of all types of cough of various etiologies.",{"v":527.6,"d":"527.60"},"52432-72-1",{"v":100,"d":"100.00"},189.54,{"v":100,"d":"100.00"},189.54,"http://www.selleckchem.com/products/oxeladin-citrate.html","C20H33NO3.C6H8O7","citrate","OL","CCN(CC)CCOCCOC(=O)C(CC)(CC)C1=CC=CC=C1.OC(=O)CC(O)(CC(O)=O)C(O)=O",-0.137,6,0,18]
["S4416","Trimipramine Maleate","f10","L4700-05","in 10mM DMSO","Others","Others",null,410.51,"521-78-8",{"v":82,"d":"82.00"},199.75,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/trimipramine-maleate.html","C24H30N2O4","maleate","N/A","CC(CN(C)C)CN1C2=C(CCC3=CC=CC=C13)C=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":1.84,"d":"1.840"},2,0,6]
["S4420","Mefloquine HCl","g10","L4700-05","in 10mM DMSO","Anti-infection","Microbiology","Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.",414.77,"51773-92-3",{"v":82,"d":"82.00"},{"v":197.7,"d":"197.70"},"<1",null,"http://selleckchem.com/products/mefloquine-hcl.html","C17H17ClF6N2O","Hydrochloride","Mefloquin hydrochloride","Cl.OC(C1CCCCN1)C2=CC(=NC3=C(C=CC=C23)C(F)(F)F)C(F)(F)F",4.684,1,2,4]
["S4422","Nitenpyram","h10","L4700-05","in 10mM DMSO","AChR,Parasite","Neuronal Signaling","Nitenpyram(Bestguard,Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.",270.72,"150824-47-8",{"v":54,"d":"54.00"},199.47,{"v":54,"d":"54.00"},199.47,"http://selleckchem.com/products/nitenpyram.html","C11H15ClN4O2","free base","Bestguard,Capstar","CCN(CC1=CC=C(Cl)N=C1)\\C(NC)=C\\[N+]([O-])=O",{"v":1.7,"d":"1.700"},1,1,6]
["S4505","Vinblastine (NSC-49842) sulfate","a11","L4700-05","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1",null,"http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4506","Acetazolamide","b11","L4700-05","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).",222.25,"59-66-5",{"v":44,"d":"44.00"},197.98,"<1",null,"http://selleckchem.com/products/acetazolamide.html","C4H6N4O3S2","free base","Diamox","CC(=O)NC1=NN=C(S1)[S](N)(=O)=O",-1.329,5,2,2]
["S4509","4-Aminoantipyrine","c11","L4700-05","in 10mM DMSO","COX","Immunology & Inflammation","4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.",203.24,"83-07-8",{"v":40,"d":"40.00"},196.81,{"v":40,"d":"40.00"},196.81,"http://selleckchem.com/products/4-aminoantipyrine.html","C11H13N3O","free base","Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A,  Minoazophene, Aminoazophene,  Aminoantipyrin","CN1N(C2=CC=CC=C2)C(=O)C(=C1C)N",0.021,1,1,1]
["S4517","Cefotaxime sodium","d11","L4700-05","in 10mM DMSO","Antibiotics,Antibiotics for Plant Cell Culture,Bacterial","Microbiology","Cefotaxime sodium(HR-756) salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria.",477.45,"64485-93-4",{"v":95,"d":"95.00"},198.97,{"v":95,"d":"95.00"},198.97,"http://selleckchem.com/products/cefotaxime-sodium.html","C16H17N5O7S2.Na","Sodium Salt","HR-756","[Na+].CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)COC(C)=O)C3=CSC(=N3)N",-2.384,7,2,8]
["S4526","Fenbufen","e11","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Fenbufen (Lederfen, CL-82204) is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.",254.28,"36330-85-5",{"v":50,"d":"50.00"},196.63,"<1",null,"http://selleckchem.com/products/fenbufen.html","C16H14O3","free base","Lederfen, CL-82204","OC(=O)CCC(=O)C1=CC=C(C=C1)C2=CC=CC=C2",2.933,2,0,5]
["S4539","Salicylic acid","f11","L4700-05","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1",null,"http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4542","Trihexyphenidyl hydrochloride","g11","L4700-05","in 10mM DMSO","AChR","Neuronal Signaling","Trihexyphenidyl hydrochloride (Benzhexol, Artane) is an antiparkinsonian agent of the antimuscarinic class.",337.93,"52-49-3",{"v":7,"d":"7.00"},20.71,"<1",null,"http://selleckchem.com/products/trihexyphenidyl-hydrochloride.html","C20H31NO.HCl","hydrochloride","Benzhexol hydrochloride, Artane hydrochloride","Cl.OC(CCN1CCCCC1)(C2CCCCC2)C3=CC=CC=C3",4.799,0,0,5]
["S4597","Lercanidipine hydrochloride","h11","L4700-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lercanidipine is a calcium channel blocker of the dihydropyridine class.",648.19,"132866-11-6",{"v":66,"d":"66.00"},101.82,"<1",null,"http://selleckchem.com/products/lercanidipine-hydrochloride.html","C36H41N3O6.HCl","hydrochloride","Zanidip (hydrochloride), Masnidipine (hydrochloride)","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C",6.514,4,1,14]
["S4601","Clioquinol","a2","L4700-06","in 10mM DMSO","Fungal","Microbiology","Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.",{"v":305.5,"d":"305.50"},"130-26-7",{"v":61,"d":"61.00"},199.67,"<1",null,"http://selleckchem.com/products/5-chloro-8-hydroxy-7-iodoquinoline.html","C9H5ClINO","free base","Iodochlorhydroxyquin, Chinoform","OC1=C(I)C=C(Cl)C2=CC=CN=C12",3.016,1,1,0]
["S4609","Diflunisal","b2","L4700-06","in 10mM DMSO","COX","Neuronal Signaling","Diflunisal (Dolobid, Dolobis, Flovacil, Fluniget,MK-647) is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.",{"v":250.2,"d":"250.20"},"22494-42-4",{"v":50,"d":"50.00"},199.84,"<1",null,"http://selleckchem.com/products/diflunisal.html","C13H8F2O3","free base","Dolobid, Dolobis, Flovacil, Fluniget,MK-647","OC(=O)C1=C(O)C=CC(=C1)C2=C(F)C=C(F)C=C2",3.147,1,1,2]
["S4610","Mebendazole","c2","L4700-06","in 10mM DMSO","Parasite","Microbiology","Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.",295.29,"31431-39-7",{"v":6,"d":"6.00"},20.32,"<1",null,"http://selleckchem.com/products/mebendazole.html","C16H13N3O3","free base","Vermox, Telmin, Pantelmin, Mebenvet","COC(=O)NC1=NC2=C([NH]1)C=CC(=C2)C(=O)C3=CC=CC=C3",3.055,4,2,4]
["S4612","Dapson","d2","L4700-06","in 10mM DMSO","Antibiotics","Microbiology","Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.",{"v":248.3,"d":"248.30"},"80-08-0",{"v":49,"d":"49.00"},197.34,"<1",null,"http://selleckchem.com/products/dapson.html","C12H12N2O2S","free base","Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS","NC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(N)C=C2",1.439,2,2,2]
["S4619","Itopride hydrochloride","e2","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Itopride hydrochloride (Ganaton, HSR803) is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.",394.89,"122892-31-3",{"v":78,"d":"78.00"},197.52,{"v":78,"d":"78.00"},197.52,"http://selleckchem.com/products/itopride-hydrochloride.html","C20H26N2O4.HCl","hydrochloride","Ganaton, HSR803","Cl.COC1=CC=C(C=C1OC)C(=O)NCC2=CC=C(OCCN(C)C)C=C2",3.093,4,1,9]
["S4623","Methylbenactyzine Bromide","f2","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Methylbenactyzine Bromide (Gastrimade, Noinarin, Paragone, Semulgin) is a kind of muscarinic cholinergic receptor antagonist with antispasmodic activity.",422.36,"3166-62-9",{"v":84,"d":"84.00"},198.88,{"v":84,"d":"84.00"},198.88,"http://selleckchem.com/products/methylbenactyzine-bromide.html","C21H28NO3.Br","bromide","Gastrimade, Noinarin, Paragone, Semulgin","[Br-].CC[N+](C)(CC)CCOC(=O)C(O)(C1=CC=CC=C1)C2=CC=CC=C2",-0.322,2,0,9]
["S4626","Ethosuximide","g2","L4700-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ethosuximide(Zarontin) is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.",141.17,"77-67-8",{"v":28,"d":"28.00"},198.34,{"v":28,"d":"28.00"},198.34,"http://selleckchem.com/products/ethosuximide.html","C7H11NO2","free base","Zarontin","CCC1(C)CC(=O)NC1=O",0.543,2,1,1]
["S4628","(+/-)-Sulfinpyrazone","h2","L4700-06","in 10mM DMSO","COX","Neuronal Signaling","Sulfinpyrazone (G-28315, NSC 75925) is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.",404.48,"57-96-5",{"v":80,"d":"80.00"},197.78,"<1",null,"http://selleckchem.com/products/sulfinpyrazone.html","C23H20N2O3S","free base","G-28315, NSC 75925","O=C1C(CC[S](=O)C2=CC=CC=C2)C(=O)N(N1C3=CC=CC=C3)C4=CC=CC=C4",3.434,3,0,6]
["S4635","Cyproheptadine hydrochloride sesquihydrate","a3","L4700-06","in 10mM DMSO","5-HT Receptor,SETD","Neuronal Signaling","Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.",350.88,"41354-29-4",{"v":70,"d":"70.00"},{"v":199.5,"d":"199.50"},"<1",null,"https://www.selleckchem.com/products/cyproheptadine-hydrochloride-sesquihydrate.html","C21H21N.HCl.3/2H2O","hydrochloride sesquihydrate","Periactin hydrochloride, Peritol","O.O.O.Cl.Cl.CN1CCC(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C24.CN5CCC(CC5)=C6C7=CC=CC=C7C=CC8=CC=CC=C68",5.478,0,0,0]
["S4648","Dantrolene sodium hemiheptahydrate","b3","L4700-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.",399.29,"24868-20-0",{"v":14,"d":"14.00"},35.06,"<1",null,"https://www.selleckchem.com/products/dantrolene-sodium-s4648.html","C14H9N4O5.7/2H2O.Na","Sodium salt hemiheptahydrate","Dantrolene sodium salt, Dantrium, Sodium dantrolene","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4651","Etoricoxib","c3","L4700-06","in 10mM DMSO","COX","Neuronal Signaling","Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.",358.84,"202409-33-4",{"v":71,"d":"71.00"},197.86,"<1",null,"http://selleckchem.com/products/etoricoxib.html","C18H15ClN2O2S","free base","Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia","CC1=NC=C(C=C1)C2=NC=C(Cl)C=C2C3=CC=C(C=C3)[S](C)(=O)=O",3.467,4,0,3]
["S4655","Sulpiride","d3","L4700-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.",341.43,"15676-16-1",{"v":68,"d":"68.00"},199.16,"<1",null,"http://selleckchem.com/products/sulpiride.html","C15H23N3O4S","free base","Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil","CCN1CCCC1CNC(=O)C2=C(OC)C=CC(=C2)[S](N)(=O)=O",0.704,4,2,6]
["S4656","Parecoxib","e3","L4700-06","in 10mM DMSO","COX","Neuronal Signaling","Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.",370.42,"198470-84-7",{"v":74,"d":"74.00"},199.77,"<1",null,"http://selleckchem.com/products/parecoxib.html","C19H18N2O4S","free base","SC-69124, Valus-P, Vorth-P","CCC(=O)N[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",3.256,5,1,5]
["S4660","Glycopyrrolate","f3","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.",398.33,"596-51-0",{"v":65,"d":"65.00"},163.18,{"v":79,"d":"79.00"},198.33,"http://selleckchem.com/products/glycopyrrolate.html","C19H28NO3.Br","bromide","Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn","[Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)C3=CC=CC=C3",-0.961,2,0,5]
["S4661","Tiagabine hydrochloride","g3","L4700-06","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.",412.01,"145821-59-6",{"v":82,"d":"82.00"},199.02,{"v":11,"d":"11.00"},{"v":26.7,"d":"26.70"},"http://selleckchem.com/products/tiagabine-hydrochloride.html","C20H25NO2S2.HCl","hydrochloride","Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride","Cl.CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(O)=O)C3=C(C)C=CS3",2.634,1,0,6]
["S4667","Lidocaine hydrochloride","h3","L4700-06","in 10mM DMSO","EGFR","Angiogenesis","Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.",{"v":270.8,"d":"270.80"},"73-78-9",{"v":54,"d":"54.00"},199.41,{"v":54,"d":"54.00"},199.41,"http://selleckchem.com/products/lidocaine-hydrochloride.html","C14H22N2O.HCl","hydrochloride","Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural","Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",3.008,1,1,5]
["S4685","Efavirenz","a4","L4700-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.",315.67,"154598-52-4",{"v":63,"d":"63.00"},199.58,"<1",null,"http://selleckchem.com/products/efavirenz.html","C14H9ClF3NO2","free base","Sustiva, Stocrin, DMP-266, DMP 266","FC(F)(F)C1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC3CC3",4.381,2,1,3]
["S4686","Vitamin E","b4","L4700-06","in 10mM DMSO","COX,VEGFR","Neuronal Signaling","Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.",430.71,"59-02-9","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/vitamin-e.html","C29H50O2","free base","Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S4687","Rivastigmine","c4","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).",250.34,"123441-03-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/rivastigmine.html","C14H22N2O2","free base","SDZ-ENA 713, Exelon","CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C",2.599,2,0,5]
["S4691","Oxybenzone","d4","L4700-06","in 10mM DMSO","Others","Others","Oxybenzone is a benzophenone derivative used as a sunscreen agent.",228.24,"131-57-7",{"v":45,"d":"45.00"},197.16,"<1",null,"http://selleckchem.com/products/oxybenzone.html","C14H12O3","free base","Eusolex 4360, Escalol 567, KAHSCREEN BZ-3, Benzophenone 3","COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O",2.975,2,1,3]
["S4693","Guanfacine Hydrochloride","e4","L4700-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.",282.55,"29110-48-3",{"v":56,"d":"56.00"},{"v":198.2,"d":"198.20"},{"v":30,"d":"30.00"},106.18,"http://selleckchem.com/products/guanfacine-hydrochloride.html","C9H9Cl2N3O.HCl","hydrochloride","Guanfacine, Tenex, Intuniv","Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl",2.412,1,2,3]
["S4718","Acetylcholine iodide","f4","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.",273.11,"2260-50-6",{"v":54,"d":"54.00"},197.72,{"v":54,"d":"54.00"},197.72,"http://selleckchem.com/products/acetylcholine-iodide.html","C7H16NO2.I","iodide salt","Acetylcolina","[I-].CC(=O)OCC[N+](C)(C)C",-4.308,2,0,4]
["S4731","Perphenazine","g4","L4700-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.",403.97,"58-39-9",{"v":74,"d":"74.00"},183.18,"<1",null,"http://selleckchem.com/products/perphenazine.html","C21H26ClN3OS","free base","Perphenazin, Trilafon, Etaperazine","OCCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4)CC1",4.157,0,1,6]
["S4732","MPTP hydrochloride","h4","L4700-06","in 10mM DMSO","Apoptosis related,Dopamine Receptor","Neuronal Signaling","MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.",209.72,"23007-85-4",{"v":20,"d":"20.00"},95.37,{"v":41,"d":"41.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/mptp-hydrochloride.html","C12H15N.HCl","hydrochloride","N/A","Cl.CN1CCC(=CC1)C2=CC=CC=C2",2.788,0,0,1]
["S4748","Ondansetron Hydrochloride Dihydrate","a5","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors.",365.85,"103639-04-9",{"v":73,"d":"73.00"},199.54,{"v":73,"d":"73.00"},199.54,"http://selleckchem.com/products/ondansetron-hcl.html","C18H19N3O.HCl.2H2O","hydrochloride","N/A","O.O.Cl.C[N]1C2=C(C(=O)C(CC2)C[N]3C=CN=C3C)C4=C1C=CC=C4",2.602,2,0,2]
["S4749","Citalopram HBr","b5","L4700-06","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.",{"v":405.3,"d":"405.30"},"59729-32-7",{"v":81,"d":"81.00"},199.85,{"v":81,"d":"81.00"},199.85,"http://selleckchem.com/products/citalopram-hbr.html","C20H21FN2O.HBr","hydrobromide","Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr","Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C3=CC=C(F)C=C3",4.212,1,0,5]
["S4751","Cisapride hydrate","c5","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.",483.96,"260779-88-2",{"v":96,"d":"96.00"},198.36,"<1",null,"https://www.selleckchem.com/products/cisapride-hydrate.html","C23H29ClFN3O4.H2O","hydrate","Propulsid, Alimix, Propulsin, Enteropride, Kinestase","O.COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C3=CC(=C(N)C=C3OC)Cl",2.578,4,2,9]
["S4765","Syringaldehyde","d5","L4700-06","in 10mM DMSO","COX","Immunology & Inflammation","Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.  Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities.",182.17,"134-96-3",{"v":36,"d":"36.00"},197.62,null,null,"http://selleckchem.com/products/syringaldehyde.html","C9H10O4","free base","Syringic aldehyde","COC1=C(O)C(=CC(=C1)C=O)OC",1.314,3,1,3]
["S4782","5-methoxyflavone","e5","L4700-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.",252.26,"42079-78-7",{"v":50,"d":"50.00"},198.21,null,null,"http://selleckchem.com/products/5-methoxyflavone.html","C16H12O3","free base","N/A","COC1=CC=CC2=C1C(=O)C=C(O2)C3=CC=CC=C3",{"v":0,"d":"0.000"},0,0,0]
["S4804","1-Naphthyl acetate","f5","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is  a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.",186.21,"830-81-9",{"v":37,"d":"37.00"},{"v":198.7,"d":"198.70"},null,null,"http://selleckchem.com/products/1-naphthyl-acetate.html","C12H10O2","free base","N/A","CC(=O)OC1=C2C=CC=CC2=CC=C1",{"v":0,"d":"0.000"},0,0,0]
["S4817","Atenolol","g5","L4700-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.",266.34,"29122-68-7",{"v":53,"d":"53.00"},198.99,{"v":35,"d":"35.00"},131.41,"http://selleckchem.com/products/atenolol.html","C14H22N2O3","free base","Tenormin, Normiten, Blokium","CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1",0.669,2,3,8]
["S4834","Propantheline bromide","h5","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Propantheline bromide (Pro-Banthine, Neometantyl, Neopepulsan) is a muscarinic antagonist used to treat gastrointestinal conditions associated with intestinal spasm and to decrease secretions during anesthesia.",448.39,"50-34-0",{"v":89,"d":"89.00"},198.49,null,null,"http://selleckchem.com/products/propantheline-bromide.html","C23H30NO3.Br","bromide","Pro-Banthine, Neometantyl, Neopepulsan","[Br-].CC(C)[N+](C)(CCOC(=O)C1C2=C(OC3=CC=CC=C13)C=CC=C2)C(C)C",0.763,3,0,7]
["S4838","Acotiamide hydrochloride","a6","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.",541.06,"773092-05-0",{"v":100,"d":"100.00"},184.82,{"v":5,"d":"5.00"},9.24,"http://selleckchem.com/products/acotiamide-hydrochloride.html","C21H30N4O5S.HCl.3H2O","hydrochloride trihydrate","YM-443 HCl, Z-338 HCl","O.O.O.Cl.COC1=CC(=C(C=C1OC)C(=O)NC2=NC(=CS2)C(=O)NCCN(C(C)C)C(C)C)O",2.325,5,3,10]
["S4839","Mosapride","b6","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.",421.89,"112885-41-3",{"v":84,"d":"84.00"},{"v":199.1,"d":"199.10"},null,null,"http://selleckchem.com/products/mosapride.html","C21H25ClFN3O3",null,"N/A","CCOC1=CC(=C(Cl)C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(F)C=C3)N",2.932,3,2,7]
["S4889","Perospirone hydrochloride","c6","L4700-06","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.",463.04,"129273-38-7",{"v":92,"d":"92.00"},198.69,null,null,"http://selleckchem.com/products/perospirone-hydrochloride.html","C23H30N4O2S.HCl","hydrochloride","SM-9018 hydrochloride","Cl.O=C1C2CCCCC2C(=O)N1CCCCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.423,3,0,6]
["S4931","Propiverine hydrochloride","d6","L4700-06","in 10mM DMSO","AChR,Calcium Channel","Transmembrane Transporters","Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.",403.94,"54556-98-8",{"v":80,"d":"80.00"},198.05,null,null,"http://selleckchem.com/products/propiverine-hydrochloride.html","C23H29NO3.ClH","HCl","N/A","Cl.CCCOC(C(=O)OC1CCN(C)CC1)(C2=CC=CC=C2)C3=CC=CC=C3",4.388,3,0,8]
["S4957","Linalool","e6","L4700-06","in 10mM DMSO","NMDAR","Neuronal Signaling","Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.",154.25,"78-70-6","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/linalool.html","C10H18O","free base","Phantol","CC(C)=CCCC(C)(O)C=C",2.735,0,0,4]
["S4980","Anamorelin","f6","L4700-06","in 10mM DMSO","GHSR","GPCR & G Protein","Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN  FLIPR assay.",{"v":546.7,"d":"546.70"},"249921-19-5",{"v":100,"d":"100.00"},182.92,"<1",null,"http://selleckchem.com/products/anamorelin.html","C31H42N6O3","free base","ONO-7643, RC-1291, ST-1291","CN(C)N(C)C(=O)C1(CCCN(C1)C(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(C)(C)N)CC4=CC=CC=C4",2.447,3,3,9]
["S4992","Nanofin","g6","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Nanofin (2,6-Dimethylpiperidine, Lupetidine, Naniopinum) is a ganglion blocker alkaloid having nicotinic acetylcholine receptor antagonist action. It has antihypertensive effect used for mild to moderate hypertension.",{"v":113.2,"d":"113.20"},"504-03-0","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/nanofin.html","C7H15N",null,"2,6-Dimethylpiperidine, Lupetidine, Naniopinum","CC1CCCC(C)N1",1.456,0,1,0]
["S5002","Fingolimod (FTY720) HCl","h6","L4700-06","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.",{"v":343.9,"d":"343.90"},"162359-56-0",{"v":69,"d":"69.00"},200.64,{"v":69,"d":"69.00"},200.64,"http://selleckchem.com/products/FTY720.html","C19H33NO2.HCl","Hydrochloride","Fingolimod Hydrochloride,FTY720","Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",{"v":4.58,"d":"4.580"},0,3,12]
["S5010","Indometacin Sodium","a7","L4700-06","in 10mM DMSO","COX","Immunology & Inflammation","Indometacin Sodium (Indomethacin Sodium) is the sodium salt of indomethacin, which is a non-selective, reversible, and competitive inhibitor of cyclooxygenases 1 and 2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects.",433.82,"74252-25-8",{"v":87,"d":"87.00"},200.55,{"v":-1,"d":"-1.00"},-2.31,"https://www.selleckchem.com/products/indometacin-sodium.html","C19H21ClNNaO7","sodium salt trihydrate","Indomethacin Sodium","O.O.O.COC1=CC2=C(C=C1)[N](C(=C2CC(=O)O[Na])C)C(=O)C3=CC=C(Cl)C=C3",3.705,4,0,5]
["S5019","Indobufen","b7","L4700-06","in 10mM DMSO","COX","Immunology & Inflammation","Indobufen (Ibustrin, K 3920) is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.",295.33,"63610-08-2",{"v":59,"d":"59.00"},199.78,null,null,"http://selleckchem.com/products/indobufen.html","C18H17NO3","free base","Ibustrin, K 3920","CCC(C(O)=O)C1=CC=C(C=C1)N2CC3=C(C=CC=C3)C2=O",3.157,2,0,4]
["S5020","Tilorone dihydrochloride","c7","L4700-06","in 10mM DMSO","Antiviral,IFN","Immunology & Inflammation","Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.",483.47,"27591-69-1",{"v":43,"d":"43.00"},88.94,{"v":96,"d":"96.00"},198.56,"http://selleckchem.com/products/tilorone-dihydrochloride.html","C25H34N2O3.2HCl","dihydrochloride","N/A","Cl.Cl.CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C=C(OCCN(CC)CC)C=C3)C2=O",5.326,3,0,12]
["S5052","Granisetron","d7","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.",312.41,"109889-09-0",{"v":11,"d":"11.00"},35.21,null,null,"http://selleckchem.com/products/granisetron.html","C18H24N4O",null,"Sancuso, Kevatril, Granisetronum, Sustol","CN1C2CCCC1CC(C2)NC(=O)C3=N[N](C)C4=C3C=CC=C4",2.401,2,1,2]
["S5060","Metadoxine","e7","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.  Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.",298.29,"74536-44-0",{"v":59,"d":"59.00"},197.79,null,null,"http://selleckchem.com/products/metadoxine.html","C8H11NO3.C5H7NO3","salt","Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat","CC1=C(O)C(=C(CO)C=N1)CO.OC(=O)C2CCC(=O)N2",-1.243,3,4,3]
["S5065","Ganciclovir sodium","f7","L4700-06","in 10mM DMSO","CMV","Microbiology","Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).",277.21,"107910-75-8",{"v":55,"d":"55.00"},198.41,{"v":55,"d":"55.00"},198.41,"https://www.selleckchem.com/products/ganciclovir-sodium.html","C9H12N5NaO4",null,"RS-21592 sodium, Cytovene IV sodium, BW 759 sodium, 2'-Nor-2'-deoxyguanosine sodium","[Na+].NC1=NC2=C(N=C[N]2COC(CO)CO)C(=N1)[O-]",-1.859,4,3,5]
["S5066","Pramipexole dihydrochloride","g7","L4700-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.",284.25,"104632-25-9",{"v":56,"d":"56.00"},197.01,null,null,"http://selleckchem.com/products/pramipexole-dihydrochloride.html","C10H17N3S.2HCl","dihydrochloride","SND919","Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",2.147,1,2,3]
["S5071","Duloxetine","h7","L4700-06","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.",297.41,"116539-59-4","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/duloxetine.html","C18H19NOS","free base","LY-248686","CNCCC(OC1=CC=CC2=CC=CC=C12)C3=CC=CS3",3.846,1,1,6]
["S5073","Donepezil","a8","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.",379.49,"120014-06-4",{"v":75,"d":"75.00"},197.63,null,null,"http://selleckchem.com/products/donepezil.html","C24H29NO3","free base","Aricept, Donepezilo","COC1=CC2=C(C=C1OC)C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)C2",4.569,3,0,6]
["S5075","Acotiamide","b8","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Acotiamide (Acofide, Z388) is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.",450.55,"185106-16-5",{"v":90,"d":"90.00"},199.76,"<1",null,"http://selleckchem.com/products/acotiamide.html","C21H30N4O5S","free base","Acofide, Z388","COC1=C(OC)C=C(C(=O)NC2=NC(=CS2)C(=O)NCCN(C(C)C)C(C)C)C(=C1)O",2.565,5,3,10]
["S5100","Pralidoxime Iodide","c8","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.",264.06,"94-63-3",{"v":52,"d":"52.00"},196.92,null,null,"http://selleckchem.com/products/pralidoxime-lodide.html","C7H9N2O.I","iodide salt","2-PAM","[I-].C[N+]1=C(C=CC=C1)\\C=N\\O",{"v":-1.56,"d":"-1.560"},1,0,1]
["S5153","Tetrahydroberberine","d8","L4700-06","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,Dopamine Receptor","Neuronal Signaling","Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.",339.39,"522-97-4",{"v":6,"d":"6.00"},17.68,null,null,"http://selleckchem.com/products/tetrahydroberberine.html","C20H21NO4","free base","Canadine","COC1=CC=C2CC3N(CCC4=CC5=C(OCO5)C=C34)CC2=C1OC",{"v":3.4,"d":"3.400"},4,0,2]
["S5177","Naproxen","e8","L4700-06","in 10mM DMSO","COX","Immunology & Inflammation","Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.",230.26,"22204-53-1",{"v":46,"d":"46.00"},199.77,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/naproxen.html","C14H14O3","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(O)=O",2.849,2,0,3]
["S5200","Diaveridine","f8","L4700-06","in 10mM DMSO","DHFR","Metabolism","Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.",260.29,"5355-16-8",{"v":25,"d":"25.00"},96.05,null,null,"http://selleckchem.com/products/diaveridine.html","C13H16N4O2","free base","AI3-23935, CCRIS-3784","COC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1",1.559,4,2,4]
["S5210","Sulfamethazine Sodium Salt","g8","L4700-06","in 10mM DMSO","Anti-infection","Microbiology","Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.",300.31,"1981-58-4",{"v":60,"d":"60.00"},199.79,null,null,"http://selleckchem.com/products/sulfamethazine-sodium-salt.html","C12H13N4O2S.Na","sodium salt","Sulfadimethyldiazine Sodium Salt","CC1=CC(=NC(=N1)N([Na])[S](=O)(=O)C2=CC=C(N)C=C2)C",0.982,4,1,3]
["S5215","Abacavir (1592U89)","h8","L4700-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.",286.33,"136470-78-5",{"v":57,"d":"57.00"},199.07,null,null,"http://selleckchem.com/products/abacavir.html","C14H18N6O","free base","N/A","NC1=NC2=C(N=C[N]2C3CC(CO)C=C3)C(=N1)NC4CC4",0.769,3,3,4]
["S5224","Adrafinil","a9","L4700-06","in 10mM DMSO","Others","Others","Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used to relieve excessive sleepiness and inattention in elderly patients.",289.35,"63547-13-7",{"v":57,"d":"57.00"},196.99,null,null,"http://selleckchem.com/products/adrafinil.html","C15H15NO3S","free base","benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028","ONC(=O)C[S](=O)C(C1=CC=CC=C1)C2=CC=CC=C2",1.745,2,1,5]
["S5238","Solifenacin (YM905)","b9","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.",362.46,"242478-37-1",{"v":72,"d":"72.00"},198.64,{"v":-1,"d":"-1.00"},-2.76,"https://www.selleckchem.com/products/solifenacin.html","C23H26N2O2","free base",null,"O=C(OC1CN2CCC1CC2)N3CCC4=C(C=CC=C4)C3C5=CC=CC=C5",4.029,2,0,3]
["S5239","Paroxetine mesylate","c9","L4700-06","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.",425.47,"217797-14-3",{"v":85,"d":"85.00"},199.78,{"v":-1,"d":"-1.00"},-2.35,"http://selleckchem.com/products/paroxetine-mesylate.html","C19H20FNO3.CH4O3S","Mesylate","BRL-29060A mesylate,FG-7051 mesylate","C[S](O)(=O)=O.FC1=CC=C(C=C1)C2CCNCC2COC3=CC=C4OCOC4=C3",2.815,3,1,4]
["S5253","Cisapride (R 51619)","d9","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.",465.95,"81098-60-4",{"v":93,"d":"93.00"},199.59,"<1",null,"http://selleckchem.com/products/cisapride.html","C23H29ClFN3O4",null,"Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid","COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C3=C(OC)C=C(N)C(=C3)Cl",2.785,4,2,9]
["S5255","Nicardipine","e9","L4700-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nicardipine is a potent calcium channel blockader with marked vasodilator action.",479.52,"55985-32-5",{"v":95,"d":"95.00"},198.11,{"v":30,"d":"30.00"},62.56,"https://www.selleckchem.com/products/nicardipine.html","C26H29N3O6",null,"YC-93","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",3.488,4,1,11]
["S5258","Revefenacin","f9","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Revefenacin (TD-4208, GSK-1160724) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.",597.75,"864750-70-9",{"v":100,"d":"100.00"},167.29,"<1",null,"http://selleckchem.com/products/revefenacin.html","C35H43N5O4",null,"TD-4208, GSK-1160724","CN(CCN1CCC(CC1)OC(=O)NC2=CC=CC=C2C3=CC=CC=C3)C(=O)C4=CC=C(CN5CCC(CC5)C(N)=O)C=C4",3.833,4,2,11]
["S5269","J147","g9","L4700-06","in 10mM DMSO","MAO","Neuronal Signaling","J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.",350.33,"1146963-51-0",{"v":70,"d":"70.00"},199.81,null,null,"http://selleckchem.com/products/j147.html","C18H17F3N2O2","free base","N/A","COC1=CC(=CC=C1)/C=N/N(C(=O)C(F)(F)F)C2=CC=C(C)C=C2C",4.845,3,0,5]
["S5298","Amoxicillin trihydrate","h9","L4700-06","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.",419.45,"61336-70-7",{"v":30,"d":"30.00"},71.52,null,null,"http://selleckchem.com/products/amoxicillin-trihydrate.html","C16H19N3O5S.3H2O","trihydrate","Amoxil trihydrate, Amoxipen trihydrate, Moxaline trihydrate","O.O.O.CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O",-3.161,3,3,4]
["S5309","Propyphenazone (4-Isopropylantipyrine)","a10","L4700-06","in 10mM DMSO","COX","Immunology & Inflammation","Propyphenazone(4-Isopropylantipyrine, Isopropyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.",230.31,"479-92-5",{"v":46,"d":"46.00"},199.73,null,null,"http://selleckchem.com/products/propyphenazone.html","C14H18N2O","free base","Isopropylantipyrine, Isopropyrine","CC(C)C1=C(C)N(C)N(C2=CC=CC=C2)C1=O",2.373,1,0,2]
["S5326","Dolasetron","b10","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Dolasetron(MDL-73147EF) is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors.",324.37,"115956-12-2",{"v":64,"d":"64.00"},197.31,"<1",null,"https://www.selleckchem.com/products/dolasetron.html","C19H20N2O3","free base","MDL-73147EF","O=C1CN2C3CC(CC2CC1C3)OC(=O)C4=C[NH]C5=C4C=CC=C5",2.035,3,1,3]
["S5358","Regadenoson","c10","L4700-06","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Regadenoson (CVT-3146, Lexiscan) is a selective A2A adenosine receptor agonist with coronary vasodilating activity.",390.35,"313348-27-5",{"v":56,"d":"56.00"},143.46,"<1",null,"http://selleckchem.com/products/regadenoson.html","C15H18N8O5","free base","CVT-3146, Lexiscan","CNC(=O)C1=C[N](N=C1)C2=NC3=C(N=C[N]3C4OC(CO)C(O)C4O)C(=N2)N",-1.925,6,5,4]
["S5383","Erucic acid","d10","L4700-06","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Erucic acid (cis-13-docosenoic acid) is a monounsaturated omega-9 fatty acid used as mineral oil and a precursor to biodiesel fuel.",338.57,"112-86-7",{"v":67,"d":"67.00"},197.89,null,null,"http://selleckchem.com/products/erucic-acid.html","C22H42O2","free base","cis-13-docosenoic acid","CCCCCCCC\\C=C/CCCCCCCCCCCC(O)=O",8.685,1,0,19]
["S5385","Imidafenacin","e10","L4700-06","in 10mM DMSO","AChR","GPCR & G Protein","Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).",{"v":319.4,"d":"319.40"},"170105-16-5",{"v":63,"d":"63.00"},197.24,{"v":-1,"d":"-1.00"},-3.13,"https://www.selleckchem.com/products/imidafenacin.html","C20H21N3O","free base","KRP-197, ONO-8025","CC1=NC=C[N]1CCC(C(N)=O)(C2=CC=CC=C2)C3=CC=CC=C3",{"v":2.55,"d":"2.550"},2,1,6]
["S5398","Nefazodone hydrochloride","f10","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Nefazodone hydrochloride (BMY-13754-1) is the hydrochloride salt form of nefazodone, which is an atypical antidepressant showing antagonistic activity on serotonin reuptake.",506.47,"82752-99-6",{"v":22,"d":"22.00"},43.44,{"v":-1,"d":"-1.00"},-1.97,"https://www.selleckchem.com/products/nefazodone-hydrochloride.html","C25H33Cl2N5O2","free base","BMY-13754-1","Cl.CCC1=NN(CCCN2CCN(CC2)C3=CC(=CC=C3)Cl)C(=O)N1CCOC4=CC=CC=C4",4.797,3,0,10]
["S5401","Tegaserod Maleate","g10","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tegaserod Maleate(HTF-919) is a hydrogen maleate salt form of tegaserod, which is a 5-HT4 receptor partial agonist and binds with high affinity to 5-HT4 receptors. It has limited affinity for 5-HT1 receptors and no appreciable affinity for other 5-HT receptors, muscarinic, adrenergic, dopaminergic or opiate receptors.",417.46,"189188-57-6",{"v":83,"d":"83.00"},198.82,"<1",null,"http://selleckchem.com/products/tegaserod-maleate.html","C16H23N5O.C4H4O4","maleate","HTF-919","CCCCCNC(=N)N/N=C/C1=C[NH]C2=C1C=C(OC)C=C2.OC(=O)\\C=C/C(O)=O",{"v":3.17,"d":"3.170"},4,3,11]
["S5405","Propylparaben","h10","L4700-06","in 10mM DMSO","Anti-infection","Microbiology","Propylparaben (Propyl 4-hydroxybenzoate, Propyl p-hydroxybenzoate, nipasol), a natural substance found in many plants and some insects, is an antimicrobial, preservative and flavouring agent.",{"v":180.2,"d":"180.20"},"94-13-3",{"v":36,"d":"36.00"},199.78,"<1",null,"https://www.selleckchem.com/products/propylparaben.html","C10H12O3",null,"Propyl 4-hydroxybenzoate, 4-Hydroxybenzoic acid propyl ester, Propyl p-hydroxybenzoate, nipasol","CCCOC(=O)C1=CC=C(O)C=C1",2.315,2,1,4]
["S5418","Parecoxib Sodium","a11","L4700-06","in 10mM DMSO","COX","Immunology & Inflammation","Parecoxib Sodium (SC-69124) is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).",{"v":392.4,"d":"392.40"},"198470-85-8",{"v":78,"d":"78.00"},198.77,{"v":-1,"d":"-1.00"},-2.55,"https://www.selleckchem.com/products/parecoxib-sodium.html","C19H17N2NaO4S","free base","SC-69124 Sodium","CCC(=O)N([Na])[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",{"v":3.36,"d":"3.360"},5,0,5]
["S5424","Carbaryl","b11","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide and also a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors.",201.22,"63-25-2",{"v":40,"d":"40.00"},198.79,null,null,"http://selleckchem.com/products/carbaryl.html","C12H11NO2","free base","1-naphthyl methylcarbamate","CNC(=O)OC1=C2C=CC=CC2=CC=C1",2.502,2,1,2]
["S5428","Promazine hydrochloride","c11","L4700-06","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.",320.88,"53-60-1",{"v":64,"d":"64.00"},199.45,null,null,"http://selleckchem.com/products/promazine-hydrochloride.html","C17H20N2S.HCl","hydrochloride","Romtiazin hydrochloride, Sinophenin hydrochloride","Cl.CN(C)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3",4.457,0,0,4]
["S5434","AS057278","d11","L4700-06","in 10mM DMSO","Others","Neuronal Signaling","AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).",126.11,"402-61-9",{"v":25,"d":"25.00"},198.24,null,null,"http://selleckchem.com/products/as057278.html","C5H6N2O2","free base","3-Methylpyrazole-5-carboxylic acid","CC1=CC(=N[NH]1)C(O)=O",0.477,2,1,1]
["S5451","Ferulic acid methyl ester","e11","L4700-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid,  which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.",208.21,"2309-07-1",{"v":41,"d":"41.00"},196.92,{"v":41,"d":"41.00"},196.92,"http://selleckchem.com/products/ferulic-acid-methylester.html","C11H12O4","free base","Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate","COC(=O)\\C=C\\C1=CC=C(O)C(=C1)OC",1.894,3,1,4]
["S5459","Aucubin","f11","L4700-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.",346.33,"479-98-1",{"v":69,"d":"69.00"},199.23,{"v":15,"d":"15.00"},43.31,"http://selleckchem.com/products/aucubin.html","C15H22O9","free base","Rhinanthin","OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O",-2.916,3,6,4]
["S5472","Nafronyl oxalate salt","g11","L4700-06","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Nafronyl oxalate salt is the oxalate salt form of nafronyl, which is a selective antagonist of 5-HT2 receptors and a vasodilator used in the management of peripheral and cerebral vascular disorders.",473.56,"3200-06-4",{"v":94,"d":"94.00"},{"v":198.5,"d":"198.50"},{"v":94,"d":"94.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/nafronyl-oxalate-salt.html","C24H33NO3.C2H2O4","oxalate","N/A","CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=C3C=CC=CC3=CC=C2.OC(=O)C(O)=O",1.048,5,0,12]
["S5480","Clidinium Bromide","h11","L4700-06","in 10mM DMSO","AChR","Neuronal Signaling","Clidinium Bromide(Ro 2-3773) is an anticholinergic drug.",432.35,"3485-62-9",{"v":86,"d":"86.00"},198.91,null,null,"http://selleckchem.com/products/clidinium-bromide.html","C22H26NO3.Br","bromide","Ro 2-3773","[Br-].C[N+]12CCC(CC1)C(C2)OC(=O)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",-0.622,2,0,5]
["S5481","Molindone hydrochloride","a2","L4700-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.",312.83,"15622-65-8",{"v":9,"d":"9.00"},28.77,null,null,"http://selleckchem.com/products/molindone-hydrochloride.html","C16H24N2O2.HCl","hydrochloride","N/A","Cl.CCC1=C(C)[NH]C2=C1C(=O)C(CC2)CN3CCOCC3",2.522,2,1,3]
["S5483","Tribenzagan Hydrochloride","b2","L4700-07","in 10mM DMSO","Others","Others","Tribenzagan Hydrochloride (Trimethobenzamide) is an orally available, antiemetic agent used in the therapy of nausea and vomiting associated with medications and gastrointestinal, viral and other illnesses.",424.92,"554-92-7",{"v":84,"d":"84.00"},197.68,null,null,"http://selleckchem.com/products/trimethobenzamide-hydrochloride.html","C21H28N2O5.HCl","hydrochloride","Trimethobenzamide Hydrochloride","Cl.COC1=C(OC)C(=CC(=C1)C(=O)NCC2=CC=C(OCCN(C)C)C=C2)OC",3.076,5,1,10]
["S5485","Desipramine Hydrochloride","c2","L4700-07","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.",302.84,"58-28-6",{"v":60,"d":"60.00"},198.12,null,null,"http://selleckchem.com/products/desipramine-hydrochloride.html","C18H22N2.HCl","hydrochloride","Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901","Cl.CNCCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.234,0,1,4]
["S5493","Atropine sulfate","d2","L4700-07","in 10mM DMSO","AChR","Neuronal Signaling","Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.",676.82,"55-48-1",{"v":18,"d":"18.00"},26.59,null,null,"https://www.selleckchem.com/products/atropine-sulfate.html","C34H46N2O6.H2SO4","sulfate","Sulfatropinol, Atropette, Tropintran","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.835,4,2,10]
["S5511","Ethyl (triphenylphosphoranylidene) acetate","e2","L4700-07","in 10mM DMSO","AChR,BChE","Neuronal Signaling","Ethyl (triphenylphosphoranylidene) acetate (Triphenylcarbethoxymethylenephosphorane, (Carbethoxymethylene)triphenylphosphorane) may act as an inhibitor of cholinesterase that inhibits AChE and BChE.",348.37,"1099-45-2",{"v":69,"d":"69.00"},198.07,null,null,"http://selleckchem.com/products/ethyl-triphenylphosphoranylidene-acetate.html","C22H21O2P","free base","(Carbethoxymethylene)triphenylphosphorane, Triphenylcarbethoxymethylenephosphorane, Ethyl 2-(triphenylphosphoranylidene)acetate","CCOC(=O)C=[P](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3",5.227,2,0,6]
["S5520","Phenidone","f2","L4700-07","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.",162.19,"92-43-3",{"v":32,"d":"32.00"},{"v":197.3,"d":"197.30"},null,null,"http://selleckchem.com/products/phenidone.html","C9H10N2O","free base","1-phenyl-3-pyrazolidinone","O=C1CCN(N1)C2=CC=CC=C2",1.112,1,1,1]
["S5538","Tropisetron","g2","L4700-07","in 10mM DMSO","5-HT Receptor,AChR","Neuronal Signaling","Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.",284.35,"89565-68-4",{"v":10,"d":"10.00"},35.17,{"v":56,"d":"56.00"},196.94,"http://selleckchem.com/products/tropisetron.html","C17H20N2O2","free base","ICS 205-930","CN1C2CCC1CC(C2)OC(=O)C3=C[NH]C4=C3C=CC=C4",2.608,2,1,3]
["S5551","6-Paradol","h2","L4700-07","in 10mM DMSO","COX","Immunology & Inflammation","6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. Paradol is an inhibitor of cyclooxygenase (COX)-2.",278.39,"27113-22-0","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/6-paradol.html","C17H26O3","free base","N/A","CCCCCCCC(=O)CCC1=CC=C(O)C(=C1)OC",{"v":4.74,"d":"4.740"},2,1,10]
["S5563","Thioridazine hydrochloride","a3","L4700-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Thioridazine (Aldazine, Mellaril) is a potent antianxiety and antipsychotic agent.",407.04,"130-61-0",{"v":81,"d":"81.00"},{"v":199,"d":"199.00"},null,null,"http://selleckchem.com/products/thioridazine-hydrochloride.html","C21H26N2S2.HCl","hydrochloride","Aldazine, Mellaril","Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC4CCCCN4C)C=C1",5.945,0,0,4]
["S5567","Trimethadione","b3","L4700-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.",143.14,"127-48-0",{"v":28,"d":"28.00"},195.61,null,null,"http://selleckchem.com/products/trimethadione.html","C6H9NO3",null,"N/A","CN1C(=O)OC(C)(C)C1=O",0.488,3,0,0]
["S5595","3-Carene","c3","L4700-07","in 10mM DMSO","COX,phosphatase","Immunology & Inflammation","3-Carene (Carene, Delta-3-Carene) is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.",136.23,"13466-78-9","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://selleckchem.com/products/3-carene.html","C10H16","free base","Carene, Delta-3-Carene","CC1=CCC2C(C1)C2(C)C",2.872,0,0,0]
["S5618","Hippuric acid","d3","L4700-07","in 10mM DMSO","Others","Others","Hippuric Acid (2-Benzamidoacetic acid, Benzoylglycine) is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine as a metabolite of aromatic compounds from food.",179.17,"495-69-2",{"v":35,"d":"35.00"},195.35,null,null,"http://selleckchem.com/products/hippuric-acid.html","C9H9NO3","free base","2-Benzamidoacetic acid, Benzoylglycine","OC(=O)CNC(=O)C1=CC=CC=C1",0.519,2,1,3]
["S5655","Venlafaxine","e3","L4700-07","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.",{"v":277.4,"d":"277.40"},"93413-69-5",{"v":55,"d":"55.00"},198.27,"<1",null,"http://selleckchem.com/products/venlafaxine.html","C17H27NO2",null,"Wy 45030","COC1=CC=C(C=C1)C(CN(C)C)C2(O)CCCCC2",3.022,1,0,5]
["S5693","Levomilnacipran Hydrochloride","f3","L4700-07","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.",282.81,"175131-60-9",{"v":57,"d":"57.00"},201.55,{"v":57,"d":"57.00"},201.55,"http://www.selleckchem.com/products/levomilnacipran-hydrochloride.html","C15H23ClN2O","Hydrochloride","N/A","Cl.CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2",{"v":1.67,"d":"1.670"},1,1,5]
["S5698","Ketorolac tromethamine salt","g3","L4700-07","in 10mM DMSO","COX","Immunology & Inflammation","Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.",{"v":376.4,"d":"376.40"},"74103-07-4",{"v":75,"d":"75.00"},199.26,{"v":75,"d":"75.00"},199.26,"http://www.selleckchem.com/products/ketorolac-tromethamine-salt.html","C19H24N2O6","tromethamine salt","N/A","NC(CO)(CO)CO.OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",-2.028,2,4,6]
["S5711","Deracoxib","h3","L4700-07","in 10mM DMSO","COX","Immunology & Inflammation","Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).",397.37,"169590-41-4",{"v":80,"d":"80.00"},201.32,"<1",null,"http://selleckchem.com/products/deracoxib.html","C17H14F3N3O3S","free base","SC-046","COC1=C(F)C=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)F",3.642,4,1,5]
["S5714","lurasidone","a4","L4700-07","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.",492.68,"367514-87-2",{"v":7,"d":"7.00"},14.21,"<1",null,"http://selleckchem.com/products/lurasidone.html","C28H36N4O2S","free base","SM-13496","O=C1C2C3CCC(C3)C2C(=O)N1CC4CCCCC4CN5CCN(CC5)C6=NSC7=CC=CC=C67",4.896,3,0,5]
["S5716","Abemaciclib (LY2835219)","b4","L4700-07","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.",506.59,"1231929-97-7",{"v":6,"d":"6.00"},11.84,"<1",null,"http://selleckchem.com/products/abemaciclib.html","C27H32F2N8","free base","LY2835219","CCN1CCN(CC1)CC2=CN=C(NC3=NC=C(F)C(=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)C=C2",4.957,4,1,7]
["S5740","Palonosetron","c4","L4700-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).",296.41,"135729-61-2",{"v":59,"d":"59.00"},199.05,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/palonosetron.html","C19H24N2O","Free Base","RS25259, RS 25259 197","O=C1N(CC2CCCC3=C2C1=CC=C3)C4CN5CCC4CC5",2.745,1,0,1]
["S5741","Quetiapine","d4","L4700-07","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.",383.51,"111974-69-7",{"v":77,"d":"77.00"},200.78,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/quetiapine.html","C21H25N3O2S","Free Base","ICI204636","OCCOCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=CC=C4",2.656,2,1,6]
["S5747","Morantel tartrate","e4","L4700-07","in 10mM DMSO","AChR","Neuronal Signaling","Morantel (CP-12009-18, UK 296418) is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs).",370.42,"26155-31-7",{"v":74,"d":"74.00"},199.77,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/morantel-tartrate.html","C16H22N2O6S","tartrate","CP-12009-18 tartrate, UK 296418 tartrate","CN1CCCN=C1/C=C/C2=C(C)C=CS2.OC(C(O)C(O)=O)C(O)=O",0.629,3,2,5]
["S5749","Chlorpromazine","f4","L4700-07","in 10mM DMSO","5-HT Receptor,Dopamine Receptor,Potassium Channel,Sodium Channel","Neuronal Signaling","Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.",318.86,"50-53-3",{"v":64,"d":"64.00"},200.72,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/chlorpromazine.html","C17H19ClN2S","Free Base","CPZ","CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",4.739,0,0,4]
["S5766","Alfuzosin","g4","L4700-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Alfuzosin(SL 77499), a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.",389.45,"81403-80-7",{"v":78,"d":"78.00"},200.28,"<1",null,"http://www.selleckchem.com/products/alfuzosin.html","C19H27N5O4","Free Base","SL 77499","COC1=CC2=NC(=NC(=C2C=C1OC)N)N(C)CCCNC(=O)C3CCCO3",1.418,6,2,8]
["S5804","N-Acetylcysteine amide","h4","L4700-07","in 10mM DMSO","HIF,Immunology & Inflammation related,NF-κB,ROS","Immunology & Inflammation","N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.",162.21,"38520-57-9",{"v":32,"d":"32.00"},197.28,{"v":32,"d":"32.00"},197.28,"http://www.selleckchem.com/products/n-acetylcysteine-amide.html","C5H10N2O2S","Free Base","N/A","CC(=O)NC(CS)C(N)=O",-1.205,2,2,3]
["S5843","Cinitapride Hydrogen Tartrate","a5","L4700-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors",552.57,"1207859-16-2",{"v":59,"d":"59.00"},106.77,{"v":5,"d":"5.00"},9.05,"http://www.selleckchem.com/products/cinitapride-hydrogen-tartrate.html","C25H36N4O10","Hydrogen Tartrate","N/A","CCOC1=CC(=C(C=C1C(=O)NC2CCN(CC2)CC3CCC=CC3)[N+]([O-])=O)N.OC(C(O)C(O)=O)C(O)=O",-2.325,4,4,10]
["S5848","Frovatriptan Succinate","b5","L4700-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.",361.39,"158930-09-7",{"v":72,"d":"72.00"},199.23,{"v":72,"d":"72.00"},199.23,"http://www.selleck.cn/products/frovatriptan-succinate.html","C18H23N3O5","Succinate","SB 209509 Succinate,VML 251 Succinate","CNC1CCC2=C(C1)C3=C([NH]2)C=CC(=C3)C(N)=O.OC(=O)CCC(O)=O",{"v":-1.65,"d":"-1.650"},3,3,5]
["S5857","Trazodone","c5","L4700-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.",371.86,"19794-93-5",{"v":45,"d":"45.00"},121.01,"<1",null,"http://www.selleck.cn/products/trazodone.html","C19H22ClN5O","Free Base","AF-1161","ClC1=CC(=CC=C1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2",2.418,2,0,5]
["S5858","Vilazodone","d5","L4700-07","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.",441.52,"163521-12-8",{"v":88,"d":"88.00"},199.31,{"v":1,"d":"1.00"},2.26,"https://www.selleckchem.com/products/vilazodone.html","C26H27N5O2","Free Base","EMD-68843, SB-659746A","NC(=O)C1=CC2=C(O1)C=CC(=C2)N3CCN(CCCCC4=C[NH]C5=C4C=C(C=C5)C#N)CC3",4.536,2,2,7]
["S5862","Metoclopramide","e5","L4700-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting.",{"v":299.8,"d":"299.80"},"364-62-5",{"v":60,"d":"60.00"},200.13,{"v":1,"d":"1.00"},3.34,"http://www.selleckchem.com/products/metoclopramide.html","C14H22ClN3O2","Free Base","N/A","CCN(CC)CCNC(=O)C1=C(OC)C=C(N)C(=C1)Cl",1.775,2,2,7]
["S5873","Scopolamine HBr trihydrate","f5","L4700-07","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.",438.31,"6533-68-2",{"v":88,"d":"88.00"},200.77,{"v":88,"d":"88.00"},200.77,"https://www.selleckchem.com/products/scopolamine-hbr-trihydrate.html","C17H28BrNO7","HBr trihydrate","N/A","O.O.O.Br.CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",0.693,3,1,5]
["S5900","Edrophonium chloride","g5","L4700-07","in 10mM DMSO","AChR","Metabolism","Edrophonium chloride is the chloride salt of edrophonium, which is a rapid-onset, short-acting, readily reversible inhibitor of acetylcholinesterase.",201.69,"116-38-1",{"v":40,"d":"40.00"},198.32,{"v":40,"d":"40.00"},198.32,"http://www.selleckchem.com/products/edrophonium-chloride.html","C10H16ClNO","chloride","N/A","[Cl-].CC[N+](C)(C)C1=CC=CC(=C1)O",-2.026,0,1,2]
["S5914","AK 7","h5","L4700-07","in 10mM DMSO","Sirtuin","Epigenetics","AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.",437.35,"420831-40-9",{"v":87,"d":"87.00"},198.93,"<1",null,"http://www.selleckchem.com/products/ak-7.html","C19H21BrN2O3S","Free Base","N/A","BrC1=CC(=CC=C1)NC(=O)C2=CC=CC(=C2)[S](=O)(=O)N3CCCCCC3",3.853,3,1,4]
["S5919","KHS101 hydrochloride","a6","L4700-07","in 10mM DMSO","Microtubule Associated,TACC3","Cytoskeletal Signaling","KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.",375.92,"1784282-12-7",{"v":75,"d":"75.00"},199.51,{"v":3,"d":"3.00"},7.98,"http://www.selleckchem.com/products/khs101-hydrochloride.html","C18H22ClN5S","hydrochloride","N/A","Cl.CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3",4.481,3,2,7]
["S5921","Cyclopentolate Hydrochloride","b6","L4700-07","in 10mM DMSO","AChR","Neuronal Signaling","Cyclopentolate is an antagonist of muscarinic acetylcholine receptors with Ki values of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.",327.85,"5870-29-1",{"v":66,"d":"66.00"},201.31,{"v":66,"d":"66.00"},201.31,"http://www.selleck.cn/products/cyclopentolate-hydrochloride.html","C17H26ClNO3","Hydrochloride","N/A","Cl.CN(C)CCOC(=O)C(C1=CC=CC=C1)C2(O)CCCC2",2.871,2,0,7]
["S5930","PNU 282987 HCl","c6","L4700-07","in 10mM DMSO","AChR","Metabolism","PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor.",301.21,"123464-89-1",{"v":46,"d":"46.00"},152.72,{"v":11,"d":"11.00"},36.52,"https://www.selleckchem.com/products/pnu-282987-hcl.html","C14H18Cl2N2O","Free Base","N/A","Cl.ClC1=CC=C(C=C1)C(=O)NC2CN3CCC2CC3",{"v":2.62,"d":"2.620"},1,1,2]
["S5931","BQCA","d6","L4700-07","in 10mM DMSO","AChR","Metabolism","BQCA (benzylquinolone carboxylic acid) is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).",309.32,"338747-41-4",{"v":13,"d":"13.00"},42.03,{"v":1,"d":"1.00"},3.23,"http://www.selleckchem.com/products/bqca.html","C18H15NO4","Free Base","benzylquinolone carboxylic acid","COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1",2.723,3,0,4]
["S5939","Bendamustine (SDX105)","e6","L4700-07","in 10mM DMSO","Others","Others","Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.",358.26,"16506-27-7",{"v":72,"d":"72.00"},200.97,"<1",null,"http://www.selleck.cn/products/bendamustine.html","C16H21Cl2N3O2","Free Base","SDX105","C[N]1C(=NC2=C1C=CC(=C2)N(CCCl)CCCl)CCCC(O)=O",3.606,2,0,9]
["S5950","Fingolimod","f6","L4700-07","in 10mM DMSO","S1P Receptor","Neuronal Signaling","Fingolimod (FTY-720A, FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.",307.47,"162359-55-9",{"v":13,"d":"13.00"},42.28,{"v":1,"d":"1.00"},3.25,"https://www.selleckchem.com/products/fingolimod.html","C19H33NO2","Free Base","FTY-720A, FTY-720","CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",4.198,0,3,12]
["S6073","Diclofenac acid","g6","L4700-07","in 10mM DMSO","COX,Immunology & Inflammation related","Immunology & Inflammation","Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.",296.15,"15307-86-5",{"v":59,"d":"59.00"},199.22,null,null,"http://www.selleck.cn/products/diclofenac-acid.html","C14H11Cl2NO2","free base","N/A","OC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",4.373,1,1,4]
["S6264","Rutin hydrate","h6","L4700-07","in 10mM DMSO","Others","Others","Rutin (Quercetin-3-O-rutinoside, Rutoside, Sophorin) is a glycoside found in a wide variety of plants including citrus fruit.",610.52,"207671-50-9",{"v":122.1,"d":"122.10"},{"v":200,"d":"200.00"},null,null,"http://www.selleck.cn/products/rutin-hydrate.html","C27H30O16.xH2O","free base","Quercetin-3-O-rutinoside, Rutoside, Sophorin","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-0.424,6,10,6]
["S6324","5-Methoxytryptamine","a7","L4700-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.",190.24,"608-07-1",38.05,{"v":200,"d":"200.00"},null,null,"http://www.selleck.cn/products/5-methoxytryptamine.html","C11H14N2O","free base","Mexamine, Methoxytryptamine","COC1=CC2=C([NH]C=C2CCN)C=C1",1.534,1,2,3]
["S6415","Azeliragon (TTP488)","b7","L4700-07","in 10mM DMSO","Others","Others","Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD.",532.12,"603148-36-3",{"v":100,"d":"100.00"},187.93,"<1",null,"http://www.selleck.cn/products/azeliragon.html","C32H38ClN3O2","Free Base","PF-04494700","CCCCC1=NC(=C[N]1C2=CC=C(OC3=CC=C(Cl)C=C3)C=C2)C4=CC=C(OCCCN(CC)CC)C=C4",8.393,3,0,14]
["S6425","JNJ 63533054","c7","L4700-07","in 10mM DMSO","GPR","GPCR & G Protein","JNJ 63533054 is a potent and selective GPR139 agonist. It specifically activated human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays.",316.78,"1802326-66-4",{"v":63,"d":"63.00"},198.88,{"v":-1,"d":"-1.00"},null,"http://www.selleck.cn/products/jnj-63533054.html","C17H17ClN2O2","Free Base","N/A","CC(NC(=O)CNC(=O)C1=CC=CC(=C1)Cl)C2=CC=CC=C2",2.723,2,2,5]
["S6432","Cevimeline HCl hemihydrate","d7","L4700-07","in 10mM DMSO","AChR","Metabolism","Cevimeline HCl hemihydrate(AF 102B, SNI 2011, SNK 508) is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3.",244.78,"153504-70-2",{"v":40,"d":"40.00"},169.66,{"v":40,"d":"40.00"},169.66,"https://www.selleckchem.com/products/cevimeline.html","C10H18ClNOS.1/2H2O","HCl hemihydrate","AF 102B, SNI 2011, SNK 508","Cl.CC1OC2(CS1)CN3CCC2CC3",2.151,1,0,0]
["S6452","Delavirdine mesylate","e7","L4700-07","in 10mM DMSO","Reverse Transcriptase","Microbiology","Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.",552.67,"147221-93-0",{"v":100,"d":"100.00"},180.94,"<1",null,"http://www.selleck.cn/products/delavirdine.html","C23H32N6O6S2","mesylate","U 90152 mesylate","CC(C)NC1=CC=CN=C1N2CCN(CC2)C(=O)C3=CC4=C([NH]3)C=CC(=C4)N[S](C)(=O)=O.C[S](O)(=O)=O",1.879,4,3,6]
["S6457","Flurbiprofen Axetil","f7","L4700-07","in 10mM DMSO","COX","Immunology & Inflammation","Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase.",330.35,"91503-79-6","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://www.selleck.cn/products/flurbiprofen-axetil.html","C19H19FO4","Free Base","N/A","CC(OC(C)=O)OC(=O)C(C)C1=CC=C(C(=C1)F)C2=CC=CC=C2",3.906,4,0,7]
["S6469","Thonzylamine","g7","L4700-07","in 10mM DMSO","AChR,Histamine Receptor","Neuronal Signaling","Thonzylamine (Neohetramine) is an antihistamine and anticholinergic drug.",286.37,"91-85-0",{"v":57,"d":"57.00"},199.04,{"v":57,"d":"57.00"},199.04,"http://www.selleck.cn/products/thonzylamine.html","C16H22N4O","Free Base","Neohetramine","COC1=CC=C(CN(CCN(C)C)C2=NC=CC=N2)C=C1",{"v":2.44,"d":"2.440"},3,0,7]
["S6575","C-176","h7","L4700-07","in 10mM DMSO","STING","Immunology & Inflammation","STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.",358.09,"314054-00-7",{"v":72,"d":"72.00"},201.07,"<1",null,"http://www.selleck.cn/products/c-176-sting-inhibitor.html","C11H7IN2O4","free base","N/A","[O-][N+](=O)C1=CC=C(O1)C(=O)NC2=CC=C(I)C=C2",2.606,2,1,3]
["S7030","RG-7112","a8","L4700-07","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1",null,"http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7038","Epoxomicin (BU-4061T)","b8","L4700-07","in 10mM DMSO","Apoptosis related,Proteasome","Proteases","Epoxomicin (BU-4061T, Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Epoxomicin promotes apoptosis.",554.72,"134381-21-8",{"v":100,"d":"100.00"},180.27,"<1",null,"http://selleckchem.com/products/epoxomicin-bu-4061t.html","C28H50N4O7","free base","Aids010837","CCC(C)C(NC(=O)C(C(C)CC)N(C)C(C)=O)C(=O)NC(=O)C(NC(CC(C)C)C(=O)C1(C)CO1)C(C)O",1.793,6,4,16]
["S7110","(+)-JQ1","c8","L4700-07","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1",null,"http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7127","TIC10 Analogue","d8","L4700-07","in 10mM DMSO","Akt","PI3K/Akt/mTOR","TIC10 Analogue is an analogue of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"41276-02-2",{"v":11,"d":"11.00"},28.46,"<1",null,"http://selleckchem.com/products/tic10.html","C24H26N4O","free base",null,"CC1=C(CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5CCN=C25)C=CC=C1",3.212,2,0,4]
["S7179","Siponimod (BAF312)","e8","L4700-07","in 10mM DMSO","S1P Receptor","GPCR & G Protein","BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.",{"v":516.6,"d":"516.60"},"1230487-00-9",{"v":100,"d":"100.00"},193.57,"<1",null,"http://selleckchem.com/products/baf312-siponimod.html","C29H35F3N2O3","free base","N/A","CCC1=CC(=CC=C1CN2CC(C2)C(O)=O)\\C(C)=N\\OCC3=CC=C(C4CCCCC4)C(=C3)C(F)(F)F",3.834,3,0,10]
["S7282","NMS-E973","f8","L4700-07","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.",454.43,"1253584-84-7",{"v":90,"d":"90.00"},198.05,"<1",null,"http://selleckchem.com/products/nms-e973.html","C22H22N4O7","free base","N/A","CN1CCC(CC1)NC(=O)C2=NOC(=C2)C3=C(OC4=CC=C(C=C4)[N+]([O-])=O)C=C(O)C=C3O",2.811,4,3,6]
["S7292","RG2833 (RGFP109)","g8","L4700-07","in 10mM DMSO","HDAC","Epigenetics","RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3 in cell-free assays, respectively.",339.43,"1215493-56-3",{"v":68,"d":"68.00"},200.34,"<1",null,"http://selleckchem.com/products/rg2833-rgfp109.html","C20H25N3O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N",2.895,2,3,8]
["S7311","Q-VD-Oph","h8","L4700-07","in 10mM DMSO","Caspase,HIV","Apoptosis","Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.",513.49,"1135695-98-5",{"v":100,"d":"100.00"},194.75,"<1",null,"http://selleckchem.com/products/q-vd-oph.html","C26H25F2N3O6","free base","Quinoline-Val-Asp-Difluorophenoxymethylketone","CC(C)C(NC(=O)C1=NC2=CC=CC=C2C=C1)C(=O)NC(CC(O)=O)C(=O)COC3=C(F)C=CC=C3F",3.397,6,2,11]
["S7337","SH-4-54","a9","L4700-07","in 10mM DMSO","STAT","JAK/STAT","SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.",610.59,"1456632-40-8",{"v":100,"d":"100.00"},163.78,"<1",null,"http://selleckchem.com/products/sh-4-54.html","C29H27F5N2O5S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(O)=O)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",6.221,4,0,9]
["S7343","URMC-099","b9","L4700-07","in 10mM DMSO","Autophagy,Bcr-Abl,LRRK2,Mixed Lineage Kinase","MAPK","URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. URMC-099 also inhibits ABL1 with IC50 of 6.8 nM. URMC-099 induces autophagy.",421.54,"1229582-33-5",{"v":84,"d":"84.00"},199.27,"<1",null,"http://selleckchem.com/products/urmc-099.html","C27H27N5","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C([NH]C=C4C5=CC=C6[NH]C=CC6=C5)N=C3",4.533,1,2,4]
["S7366","LY2119620","d9","L4700-07","in 10mM DMSO","AChR","Neuronal Signaling","LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.",437.94,"886047-22-9",{"v":87,"d":"87.00"},198.66,"<1",null,"http://selleckchem.com/products/ly2119620.html","C19H24ClN5O3S","free base","N/A","CN1CCN(CC1)C(=O)COC2=C(Cl)C(=C3C(=C(SC3=N2)C(=O)NC4CC4)N)C",1.879,4,2,5]
["S7397","Sorafenib (BAY 43-9006)","e9","L4700-07","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1",null,"http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7430","SB-3CT","f9","L4700-07","in 10mM DMSO","MMP","Proteases","SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.",{"v":306.4,"d":"306.40"},"292605-14-2",{"v":61,"d":"61.00"},199.09,"<1",null,"http://selleckchem.com/products/sb-3ct.html","C15H14O3S2","free base","N/A","O=[S](=O)(CC1CS1)C2=CC=C(OC3=CC=CC=C3)C=C2",3.377,3,0,5]
["S7440","Ribociclib (LEE011)","g9","L4700-07","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.",434.54,"1211441-98-3",{"v":7,"d":"7.00"},16.11,"<1",null,"http://selleckchem.com/products/lee011.html","C23H30N8O","free base","N/A","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",{"v":2.9,"d":"2.900"},4,2,5]
["S7458","VER-49009","h9","L4700-07","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-49009 (CCT0129397) is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.",387.82,"940289-57-6",{"v":77,"d":"77.00"},198.55,"<1",null,"http://selleckchem.com/products/ver-49009.html","C19H18ClN3O4","free base","CCT0129397","CCNC(=O)C1=C(C2=CC=C(OC)C=C2)C(=N[NH]1)C3=CC(=C(O)C=C3O)Cl",3.751,3,4,5]
["S7585","SB-334867","a10","L4700-07","in 10mM DMSO","OX Receptor","GPCR & G Protein","SB-334867 is a selective orexin-1 (OX1) receptor antagonist.",319.32,"792173-99-0",{"v":63,"d":"63.00"},197.29,"<1",null,"http://selleckchem.com/products/sb-334867.html","C17H13N5O2","free base","N/A","CC1=NC2=C(O1)C=C(NC(=O)NC3=CC=NC4=CC=CN=C34)C=C2",1.773,5,2,2]
["S7612","PX-478 2HCl","b10","L4700-07","in 10mM DMSO","Apoptosis related,HIF","Angiogenesis","PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.",394.12,"685898-44-6",{"v":78,"d":"78.00"},197.91,{"v":78,"d":"78.00"},197.91,"http://selleckchem.com/products/px-478-2hcl.html","C13H20Cl4N2O3","dihydrochloride","N/A","Cl.Cl.NC(CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O",-0.251,1,1,8]
["S7627","LDN-214117","c10","L4700-07","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LDN-214117 is a potent and selective BMP type I receptor kinase ALK2 inhibitor with IC50 of 24 nM.",419.52,"1627503-67-6",{"v":83,"d":"83.00"},197.85,"<1",null,"http://selleckchem.com/products/ldn-214117.html","C25H29N3O3","free base","N/A","COC1=CC(=CC(=C1OC)OC)C2=CC(=CN=C2C)C3=CC=C(C=C3)N4CCNCC4",3.533,4,1,6]
["S7699","Liproxstatin-1","d10","L4700-07","in 10mM DMSO","Ferroptosis","Metabolism","Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.",340.85,"950455-15-9",{"v":68,"d":"68.00"},{"v":199.5,"d":"199.50"},"<1",null,"http://selleckchem.com/products/liproxstatin-1.html","C19H21ClN4","free base","N/A","ClC1=CC(=CC=C1)CNC2=NC3=C(NC24CCNCC4)C=CC=C3",2.598,1,3,3]
["S7718","BMH-21","e10","L4700-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.",360.41,"896705-16-1",{"v":5,"d":"5.00"},13.87,"<1",null,"http://selleckchem.com/products/bmh-21.html","C21H20N4O2","free base","N/A","CN(C)CCNC(=O)C1=CC=CN2C(=O)C3=C(C=C4C=CC=CC4=C3)N=C12",1.552,3,1,4]
["S7725","BLZ945","f10","L4700-07","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","BLZ945(Sotuletinib) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.",398.48,"953769-46-5",{"v":79,"d":"79.00"},198.25,"<1",null,"http://selleckchem.com/products/blz945.html","C20H22N4O3S","free base","Sotuletinib","CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(NC4CCCCC4O)S3",3.201,4,3,5]
["S7731","AZD3839","g10","L4700-07","in 10mM DMSO","BACE","Neuronal Signaling","AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.",431.41,"1227163-84-9",{"v":86,"d":"86.00"},199.35,"<1",null,"http://selleckchem.com/products/azd3839.html","C24H16F3N5","free base","N/A","NC1=NC(C2=CC=CC(=C2)C3=CN=CN=C3)(C4=CC(=NC=C4)C(F)F)C5=CC=CC(=C15)F",3.574,4,1,4]
["S7741","SB239063","h10","L4700-07","in 10mM DMSO","p38 MAPK","MAPK","SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.",{"v":368.4,"d":"368.40"},"193551-21-2",{"v":60,"d":"60.00"},162.87,"<1",null,"http://selleckchem.com/products/sb239063.html","C20H21FN4O2","free base","N/A","COC1=NC=CC(=N1)C2=C(N=C[N]2C3CCC(O)CC3)C4=CC=C(F)C=C4",3.661,4,1,4]
["S7751","VER155008","a11","L4700-07","in 10mM DMSO","Autophagy,HSP (HSP90)","Cytoskeletal Signaling","VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.",{"v":556.4,"d":"556.40"},"1134156-31-2",{"v":100,"d":"100.00"},179.73,"<1",null,"http://selleckchem.com/products/ver155008.html","C25H23Cl2N7O4","free base","C07","NC1=C2N=C(NCC3=CC=C(Cl)C(=C3)Cl)[N](C4OC(COCC5=CC=C(C=C5)C#N)C(O)C4O)C2=NC=N1",3.253,5,4,8]
["S7781","Sunitinib (SU11248)","b11","L4700-07","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1",null,"http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7786","Erlotinib (OSI-774)","c11","L4700-07","in 10mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.",393.44,"183321-74-6",{"v":78,"d":"78.00"},198.25,"<1",null,"http://selleckchem.com/products/erlotinib.html","C22H23N3O4","free base","CP358774, NSC 718781, Tarceva","COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.309,6,1,10]
["S7792","SRT2104 (GSK2245840)","d11","L4700-07","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.",516.64,"1093403-33-8",{"v":16,"d":"16.00"},30.97,"<1",null,"http://selleckchem.com/products/srt2104-gsk2245840.html","C26H24N6O2S2","free base","N/A","CC1=C(SC(=N1)C2=CC=CN=C2)C(=O)NC3=C(C=CC=C3)C4=C[N]5C(=CSC5=N4)CN6CCOCC6",2.813,5,1,6]
["S7798","GNE-317","e11","L4700-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GNE-317 is a potent, brain-penetrant PI3K inhibitor.",414.48,"1394076-92-6",{"v":47,"d":"47.00"},{"v":113.4,"d":"113.40"},"<1",null,"http://selleckchem.com/products/gne-317.html","C19H22N6O3S","free base","N/A","COC1(COC1)C2=C(C)C3=C(S2)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",{"v":1.5,"d":"1.500"},7,1,4]
["S7818","Pexidartinib (PLX3397)","f11","L4700-07","in 10mM DMSO","Apoptosis related,c-Kit,CSF-1R,FLT3","Protein Tyrosine Kinase","Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.",417.81,"1029044-16-3",{"v":83,"d":"83.00"},198.65,"<1",null,"http://selleckchem.com/products/pexidartinib-plx3397.html","C20H15ClF3N5","free base","N/A","FC(F)(F)C1=NC=C(CNC2=NC=C(CC3=C[NH]C4=NC=C(Cl)C=C34)C=C2)C=C1",4.811,3,2,6]
["S7863","SC79","g11","L4700-07","in 10mM DMSO","Akt","PI3K/Akt/mTOR","SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.",364.78,"305834-79-1",{"v":72,"d":"72.00"},197.38,"<1",null,"http://selleckchem.com/products/sc79.html","C17H17ClN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Cl",2.427,5,1,7]
["S7889","Xanthohumol","h11","L4700-07","in 10mM DMSO","Acyltransferase,Apoptosis related,CMV,COX","Metabolism","Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.",{"v":354.4,"d":"354.40"},"6754-58-1",{"v":70,"d":"70.00"},197.52,"<1",null,"http://selleckchem.com/products/xanthohumol.html","C21H22O5","free base","N/A","COC1=C(C(=C(CC=C(C)C)C(=C1)O)O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.816,2,3,6]
["S7912","BMS202 (PD-1/PD-L1 inhibitor 2)","a2","L4700-08","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","BMS202 (PD-1/PD-L1 inhibitor 2) is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.",419.52,"1675203-84-5",{"v":83,"d":"83.00"},197.85,"<1",null,"http://selleckchem.com/products/pd-1-pd-l1-inhibitor-2.html","C25H29N3O3","free base","N/A","COC1=C(CNCCNC(C)=O)C=CC(=N1)OCC2=C(C)C(=CC=C2)C3=CC=CC=C3",4.043,4,2,10]
["S7941","NCT-501","b2","L4700-08","in 10mM DMSO","Dehydrogenase","Metabolism","NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.",416.52,"1802088-50-1",{"v":32,"d":"32.00"},76.83,"<1",null,"http://selleckchem.com/products/nct-501.html","C21H32N6O3","free base","N/A","CC(C)CC[N]1C(=NC2=C1C(=O)N(C)C(=O)N2C)CN3CCN(CC3)C(=O)C4CC4",1.722,4,0,6]
["S7952","Ozanimod (RPC1063)","c2","L4700-08","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.",404.46,"1306760-87-1",{"v":81,"d":"81.00"},200.27,"<1",null,"http://selleckchem.com/products/ozanimod-rpc1063.html","C23H24N4O3","free base","N/A","CC(C)OC1=CC=C(C=C1C#N)C2=NC(=NO2)C3=CC=CC4=C3CCC4NCCO",3.291,4,2,7]
["S7963","TIC10 (ONC201)","e2","L4700-08","in 10mM DMSO","Akt,Apoptosis related,ERK,TNF-alpha","PI3K/Akt/mTOR","TIC10 (ONC201) inactivates Akt and ERK to induce TNF-related apoptosis-inducing ligand (TRAIL) through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"1616632-77-9",{"v":77,"d":"77.00"},199.23,"<1",null,"http://selleckchem.com/products/tic-10.html","C24H26N4O","free base","ONC201","CC1=CC=CC=C1CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25",3.212,2,0,4]
["S7971","Zorifertinib (AZD3759)","f2","L4700-08","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Zorifertinib (AZD3759) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. Phase 1.",{"v":459.9,"d":"459.90"},"1626387-80-1",{"v":91,"d":"91.00"},197.87,"<1",null,"http://selleckchem.com/products/azd3759.html","C22H23ClFN5O3","free base","N/A","COC1=C(OC(=O)N2CCN(C)CC2C)C=C3C(=NC=NC3=C1)NC4=CC=CC(=C4F)Cl",4.635,5,1,5]
["S7998","Entrectinib (RXDX-101)","g2","L4700-08","in 10mM DMSO","ALK,Autophagy,ROS1,Trk receptor","Protein Tyrosine Kinase","Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.",560.64,"1108743-60-7",{"v":100,"d":"100.00"},178.37,"<1",null,"http://selleckchem.com/products/entrectinib-rxdx-101.html","C31H34F2N6O2","free base","NMS-E628","CN1CCN(CC1)C2=CC=C(C(=O)NC3=N[NH]C4=C3C=C(CC5=CC(=CC(=C5)F)F)C=C4)C(=C2)NC6CCOCC6",4.952,3,3,7]
["S7999","SKF96365","h2","L4700-08","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8010","PRX-08066 Maleic acid","a3","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.",517.96,"866206-55-5",{"v":104,"d":"104.00"},200.79,{"v":104,"d":"104.00"},200.79,"http://selleckchem.com/products/prx-08066.html","C19H17ClFN5S.C4H4O4","Maleate","N/A","OC(=O)\\C=C/C(O)=O.FC1=CC=C(CN2CCC(CC2)NC3=NC=NC4=C3C=C(Cl)S4)C=C1C#N",0.701,4,1,6]
["S8037","Necrostatin-1","b3","L4700-08","in 10mM DMSO","Apoptosis related,Autophagy,IDO/TDO,RIP kinase,TNF-alpha","Apoptosis","Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.",259.33,"4311-88-0",{"v":51,"d":"51.00"},196.66,"<1",null,"http://selleckchem.com/products/necrostatin-1.html","C13H13N3OS","free base","Nec-1","CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S",2.472,1,2,2]
["S8161","ON123300","c3","L4700-08","in 10mM DMSO","AMPK,CDK,c-RET,FGFR,PDGFR,Src","Cell Cycle","ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn, respectively.",429.52,"1357470-29-1",{"v":29,"d":"29.00"},67.52,"<1",null,"http://selleckchem.com/products/on123300.html","C24H27N7O","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C4C=C(C#N)C(=O)N(C5CCCC5)C4=N3)C=C2",{"v":3.65,"d":"3.650"},3,1,4]
["S8163","Paxalisib (GDC-0084)","d3","L4700-08","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.",382.42,"1382979-44-3",{"v":8,"d":"8.00"},20.92,"<1",null,"http://selleckchem.com/products/gdc-0084.html","C18H22N8O2","free base","RG7666","CC1(C)OCC[N]2C3=C(N=C12)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",0.588,7,1,2]
["S8166","tirabrutinib(ONO-4059) hydrochloride","e3","L4700-08","in 10mM DMSO","BTK","Angiogenesis","Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with an IC50 of 2.2 nM.",490.94,"1439901-97-9",{"v":98,"d":"98.00"},199.62,"<1",null,"http://selleckchem.com/products/ono-4059-gs-4059.html","C25H22N6O3.HCl","hydrochloride","GS-4059","Cl.CC#CC(=O)N1CCC(C1)N2C(=O)N(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C25",3.706,5,1,5]
["S8183","Pimavanserin tartrate","f3","L4700-08","in 10mM DMSO","5-HT Receptor","GPCR & G Protein","Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.",{"v":1005.2,"d":"1005.20"},"706782-28-7",{"v":100,"d":"100.00"},99.48,{"v":100,"d":"100.00"},99.48,"http://selleckchem.com/products/pimavanserin.html","C50H68F2N6O4.C4H6O6","tartrate","ACP-103","CC(C)COC1=CC=C(CNC(=O)N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)C=C1.CC(C)COC4=CC=C(CNC(=O)N(CC5=CC=C(F)C=C5)C6CCN(C)CC6)C=C4.OC(C(O)C(O)=O)C(O)=O",0.735,6,4,19]
["S8185","FPS-ZM1","g3","L4700-08","in 10mM DMSO","Beta Amyloid,Gamma-secretase","Neuronal Signaling","FPS-ZM1 is a blood-brain-barrier permeant, non-toxic, tertiary amide compound which is a high affinity RAGE-specific inhibitor, blocking Aβ binding to the V domain of RAGE.",327.85,"945714-67-0",{"v":65,"d":"65.00"},198.26,"<1",{"$error":"#VALUE!"},"http://selleckchem.com/products/fps-zm1.html","C20H22ClNO","free base","N/A","ClC1=CC=C(C=C1)C(=O)N(CC2=CC=CC=C2)C3CCCCC3",{"v":5.35,"d":"5.350"},1,0,4]
["S8193","Lanabecestat (AZD3293)","h3","L4700-08","in 10mM DMSO","BACE","Neuronal Signaling","Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki  of 0.4 nM.",412.53,"1383982-64-6",{"v":82,"d":"82.00"},198.77,"<1",null,"http://selleckchem.com/products/azd3293-ly3314814.html","C26H28N4O","free base","LY3314814","COC1CCC2(CC1)CC3=C(C=C(C=C3)C4=CN=CC(=C4)C#CC)C25N=C(C)C(=N5)N",3.882,4,1,3]
["S8202","PF-06447475","a4","L4700-08","in 10mM DMSO","LRRK2","Autophagy","PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.",305.33,"1527473-33-1",{"v":61,"d":"61.00"},199.78,"<1",null,"http://selleckchem.com/products/pf-06447475.html","C17H15N5O","free base","N/A","N#CC1=CC=CC(=C1)C2=C[NH]C3=NC=NC(=C23)N4CCOCC4",{"v":2.33,"d":"2.330"},3,1,2]
["S8238","SB366791","b4","L4700-08","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.",287.74,"472981-92-3",{"v":57,"d":"57.00"},{"v":198.1,"d":"198.10"},"<1",null,"http://selleckchem.com/products/sb366791.html","C16H14ClNO2","free base","N/A","COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(Cl)C=C2",{"v":3.73,"d":"3.730"},2,1,4]
["S8241","Ponesimod","c4","L4700-08","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.",460.97,"854107-55-4",{"v":92,"d":"92.00"},199.58,"<1",null,"http://selleckchem.com/products/ponesimod-act-128800.html","C23H25ClN2O4S","free base","ACT-128800","CCCN=C1S\\C(=C/C2=CC=C(OCC(O)CO)C(=C2)Cl)C(=O)N1C3=CC=CC=C3C",4.941,3,2,8]
["S8320","SKL2001","d4","L4700-08","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.",286.29,"909089-13-0",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1",null,"http://selleckchem.com/products/skl2001.html","C14H14N4O3","free base","N/A","O=C(NCCC[N]1C=CN=C1)C2=NOC(=C2)C3=CC=CO3",0.929,5,1,6]
["S8323","ITSA-1 (ITSA1)","e4","L4700-08","in 10mM DMSO","HDAC","Epigenetics","ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors.",292.12,"200626-61-5",{"v":58,"d":"58.00"},198.55,"<1",null,"http://selleckchem.com/products/itsa-1-itsa1.html","C13H7Cl2N3O","free base","N/A","ClC1=CC=C(C(=C1)Cl)C(=O)[N]2N=NC3=CC=CC=C23",4.418,3,0,1]
["S8355","APS-2-79 HCl","f4","L4700-08","in 10mM DMSO","MEK","MAPK","APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. IC50=120 ± 23 nM.",423.89,"2002381-31-7",{"v":97,"d":"97.00"},228.83,"<1",null,"http://selleckchem.com/products/aps-2-79.html","C23H21N3O3.HCl","hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=C(OC4=CC=CC=C4)C=C3C",5.873,5,1,6]
["S8390","LXR-623 (WAY-252623)","g4","L4700-08","in 10mM DMSO","Liver X Receptor","Metabolism","LXR-623 (WAY-252623) is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.",422.78,"875787-07-8",{"v":84,"d":"84.00"},198.68,"<1",null,"http://selleckchem.com/products/lxr-623-way-252623.html","C21H12ClF5N2","free base","N/A","FC1=CC=C(C=C1)C2=C3C=CC=C(C3=N[N]2CC4=CC=C(F)C=C4Cl)C(F)(F)F",7.227,1,0,4]
["S8401","Erdafitinib (JNJ-42756493)","h4","L4700-08","in 10mM DMSO","Apoptosis related,c-Kit,c-RET,CSF-1R,FGFR,PDGFR,VEGFR","Angiogenesis","Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Erdafitinib also binds to RET (c-RET), CSF-1R, PDGFR-α/PDGFR-β, FLT4, Kit (c-Kit) and VEGFR-2 and induces cellular apoptosis.",446.54,"1346242-81-6",{"v":89,"d":"89.00"},199.31,"<1",null,"http://selleckchem.com/products/jnj-42756493-erdafitinib.html","C25H30N6O2","free base","N/A","COC1=CC(=CC(=C1)N(CCNC(C)C)C2=CC3=NC(=CN=C3C=C2)C4=C[N](C)N=C4)OC",3.943,5,1,9]
["S8419","Stenoparib (E7449)","a5","L4700-08","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.",317.34,"1140964-99-3",{"v":4,"d":"4.00"},{"v":12.6,"d":"12.60"},"<1",null,"http://selleckchem.com/products/e7449.html","C18H15N5O","free base","2X-121, MGI25036","O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5",1.436,3,2,2]
["S8433","NS-398 (NS398)","b5","L4700-08","in 10mM DMSO","COX","Neuronal Signaling","NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.",314.36,"123653-11-2",{"v":62,"d":"62.00"},197.23,"<1",null,"http://selleckchem.com/products/ns-398-ns398.html","C13H18N2O5S","free base","N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide","C[S](=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O",2.477,3,1,5]
["S8447","8-OH-DPAT (8-Hydroxy-DPAT)","c5","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.",247.38,"78950-78-4",{"v":49,"d":"49.00"},198.08,"<1",null,"http://selleckchem.com/products/8-oh-dpat-8-hydroxy-dpat.html","C16H25NO","free base","N/A","CCCN(CCC)C1CCC2=CC=CC(=C2C1)O",4.287,0,1,5]
["S8448","ZINC00881524 (ROCK inhibitor)","d5","L4700-08","in 10mM DMSO","ROCK","Cell Cycle","ZINC00881524 is a ROCK inhibitor.",380.46,"557782-81-7",{"v":76,"d":"76.00"},199.76,"<1",null,"http://selleckchem.com/products/zinc00881524-rock-inhibitor.html","C21H20N2O3S","free base","N/A","COC1=C(OC)C=C(CC(=O)NC2=NC3=C(CCC4=CC=CC=C34)S2)C=C1",4.031,4,1,5]
["S8456","VPS34 inhibitor 1 (Compound 19)","e5","L4700-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.",391.47,"1383716-46-8",{"v":78,"d":"78.00"},199.25,"<1",null,"http://selleckchem.com/products/vps34-inhibitor-1.html","C21H25N7O","free base","PIK-III analogue","CC(C)(O)CNC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",2.798,5,2,8]
["S8459","TAK-063","f5","L4700-08","in 10mM DMSO","PDE","Metabolism","TAK-063 (Balipodect) is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM.",428.42,"1238697-26-1",{"v":85,"d":"85.00"},{"v":198.4,"d":"198.40"},"<1",null,"http://selleckchem.com/products/tak-063.html","C23H17FN6O2","free base","Balipodect","COC1=CN(N=C(C1=O)C2=CC=N[N]2C3=CC=CC=C3)C4=CC=C(C=C4F)[N]5C=CC=N5",3.983,5,0,5]
["S8484","GSK2982772","g5","L4700-08","in 10mM DMSO","RIP kinase,TNF-alpha","Apoptosis","GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase (RIPK1) inhibitor with the IC50 value of 16 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.",{"v":377.4,"d":"377.40"},"1622848-92-3",{"v":75,"d":"75.00"},198.73,"<1",null,"http://selleckchem.com/products/gsk2982772.html","C20H19N5O3","free base","N/A","CN1C(=O)C(COC2=CC=CC=C12)NC(=O)C3=N[NH]C(=N3)CC4=CC=CC=C4",1.639,5,2,4]
["S8557","IDO inhibitor 1","h5","L4700-08","in 10mM DMSO","IDO/TDO","Metabolism","IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM.",497.63,"1668565-74-9",{"v":99,"d":"99.00"},198.94,null,null,"http://selleckchem.com/products/ido-inhibitor-1.html","C29H35N7O","free base","N/A","CC(C)CN(CC(C)C)C1=CC=C(C=C1NC(=O)NC2=CC=C(C)C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4",6.102,4,3,9]
["S8565","Omarigliptin (MK-3102)","a6","L4700-08","in 10mM DMSO","DPP","Proteases","Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).",398.43,"1226781-44-7",{"v":79,"d":"79.00"},198.28,"<1",null,"http://selleckchem.com/products/omarigliptin-mk-3102.html","C17H20F2N4O3S","free base","N/A","C[S](=O)(=O)[N]1C=C2CN(CC2=N1)C3COC(C(N)C3)C4=C(F)C=CC(=C4)F",1.098,4,1,3]
["S8592","Pamiparib (BGB-290)","b6","L4700-08","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Pamiparib (BGB-290) is a potent and selective inhibitor of PARP1 and PARP2 with IC50 values of 0.83 and 0.11 nM, respectively in biochemical assays. It shows high selectivity over other PARP enzymes.",298.31,"1446261-44-4",{"v":59,"d":"59.00"},197.78,"<1",null,"http://www.selleckchem.com/products/bgb-290.html","C16H15FN4O","Free Base","N/A","CC12CCCN1CC3=NNC(=O)C4=CC(=CC5=C4C3=C2[NH]5)F",2.078,2,2,0]
["S8598","S 38093","c6","L4700-08","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.",288.38,"862896-30-8",{"v":57,"d":"57.00"},197.66,"<1",null,"http://selleckchem.com/products/S-38093.html","C17H24N2O2","free base","N/A","NC(=O)C1=CC=C(OCCCN2CC3CCCC3C2)C=C1",2.201,2,1,6]
["S8603","NGP 555","d6","L4700-08","in 10mM DMSO","Secretase","Proteases","NGP 555 is a small-molecule modulator of  γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.",406.52,"1304630-27-0",{"v":40,"d":"40.00"},{"v":98.4,"d":"98.40"},"<1",null,"http://selleckchem.com/products/npg-555.html","C23H23FN4S","free base","N/A","CCC1=C(C)C=C(C)C(=C1)NC2=NC(=CS2)C3=CC=C([N]4C=NC(=C4)C)C(=C3)F",6.396,2,1,5]
["S8611","Vorasidenib (AG-881)","e6","L4700-08","in 10mM DMSO","Dehydrogenase","Metabolism","Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2).",414.74,"1644545-52-7",{"v":82,"d":"82.00"},197.71,"<1",null,"http://selleckchem.com/products/ag-881.html","C14H13ClF6N6","free base","N/A","CC(NC1=NC(=NC(=N1)C2=CC=CC(=N2)Cl)NC(C)C(F)(F)F)C(F)(F)F",5.146,4,2,7]
["S8632","Chk2 Inhibitor II (BML-277)","f6","L4700-08","in 10mM DMSO","Apoptosis related,Chk","Cell Cycle","Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Chk2 Inhibitor II (BML-277) dose dependently protects human CD4(+) and CD8(+) T-cells from apoptosis due to ionizing radiation.",{"v":363.8,"d":"363.80"},"516480-79-8",{"v":72,"d":"72.00"},197.91,"<1",null,"http://selleckchem.com/products/chk2-inhibitor-2-bml-277.html","C20H14ClN3O2","free base","N/A","NC(=O)C1=CC=C2[NH]C(=NC2=C1)C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3",4.497,3,2,4]
["S8657","PF-06840003","g6","L4700-08","in 10mM DMSO","IDO/TDO","Metabolism","PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.",232.21,"198474-05-4",{"v":46,"d":"46.00"},{"v":198.1,"d":"198.10"},"<1",null,"http://selleckchem.com/products/pf-06840003.html","C12H9FN2O2","free base","EOS200271","FC1=CC=C2[NH]C=C(C3CC(=O)NC3=O)C2=C1",1.201,2,2,1]
["S8680","AZD1390","h6","L4700-08","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.",477.57,"2089288-03-7",{"v":14,"d":"14.00"},29.32,"<1",null,"http://selleckchem.com/products/azd1390.html","C27H32FN5O2","free base","N/A","CC(C)N1C(=O)N(C)C2=C1C3=CC(=C(F)C=C3N=C2)C4=CC=C(OCCCN5CCCCC5)N=C4",4.231,4,0,7]
["S8685","AS1517499","a7","L4700-08","in 10mM DMSO","STAT","JAK/STAT","AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.",397.86,"919486-40-1",{"v":79,"d":"79.00"},198.56,"<1",null,"http://selleckchem.com/products/as1517499.html","C20H20ClN5O2","free base","N/A","NC(=O)C1=CN=C(NCCC2=CC=C(O)C(=C2)Cl)N=C1NCC3=CC=CC=C3",3.641,3,4,8]
["S8725","A-804598","b7","L4700-08","in 10mM DMSO","P2 Receptor","Neuronal Signaling","A-804598 is a selective P2X7R antagonist with high affinity at rat (IC50 = 10 nM), mouse (IC50 = 9 nM) and human (IC50 = 11 nM) P2X7 receptors.",315.37,"1125758-85-1",{"v":63,"d":"63.00"},199.77,"<1",null,"http://selleckchem.com/products/a-804598.html","C19H17N5","free base","N/A","CC(NC(NC#N)=NC1=C2C=CC=NC2=CC=C1)C3=CC=CC=C3",3.286,2,2,5]
["S8729","AZ32","c7","L4700-08","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.",328.37,"2288709-96-4",{"v":66,"d":"66.00"},200.99,"<1",null,"http://www.selleckchem.com/products/az32.html","C20H16N4O","Free Base","N/A","CNC(=O)C1=CC=C(C=C1)C2=CN=C3C=NC(=C[N]23)C4=CC=CC=C4",2.521,3,1,3]
["S8738","Bimiralisib (PQR309)","d7","L4700-08","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.",411.38,"1225037-39-7",{"v":6,"d":"6.00"},14.59,"<1",null,"http://www.selleckchem.com/products/pqr309-bimiralisib.html","C17H20F3N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C(=C1)C(F)(F)F",1.891,6,1,4]
["S8823","ABX-1431","e7","L4700-08","in 10mM DMSO","Lipase","Metabolism","ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.",507.39,"1446817-84-0",{"v":100,"d":"100.00"},197.09,"<1",null,"http://www.selleck.cn/products/abx-1431.html","C20H22F9N3O2","Free Base","N/A","FC(F)(F)C(OC(=O)N1CCN(CC1)CC2=C(C=C(C=C2)C(F)(F)F)N3CCCC3)C(F)(F)F",5.372,2,0,8]
["S9039","Albiflorin","f7","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.",480.46,"39011-90-0",{"v":10,"d":"10.00"},20.81,null,null,"https://www.selleckchem.com/products/albiflorin.html","C23H28O11","free base","OA10410","CC12CC(O)C3CC1(OC4OC(CO)C(O)C(O)C4O)C3(COC(=O)C5=CC=CC=C5)C(=O)O2",-1.333,6,5,7]
["S9055","Salvianolic acid A","g7","L4700-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.",494.45,"96574-01-5",{"v":10,"d":"10.00"},20.22,null,null,"https://www.selleckchem.com/products/salvianolic-acid-a.html","C26H22O10","free base","Dan Phenolic Acid A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)\\C=C\\C2=C(/C=C/C3=CC(=C(O)C=C3)O)C(=C(O)C=C2)O",4.209,3,6,9]
["S9065","Songorine","h7","L4700-08","in 10mM DMSO","ADC Cytotoxin,GABA Receptor","Neuronal Signaling","Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.",357.49,"509-24-0",{"v":10,"d":"10.00"},27.97,null,null,"https://www.selleckchem.com/products/songorine.html","C22H31NO3","free base","FS145273","CCN1CC2(C)CCC(O)C34C1C(CC23)C56CC(C(=C)C5O)C(=O)CC46",1.035,1,2,1]
["S9069","Jatrorrhizine chloride","a8","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.",373.83,"6681-15-8",{"v":10,"d":"10.00"},26.75,null,null,"https://www.selleckchem.com/products/jatrorrhizine-chloride.html","C20H20ClNO4",null,"Neprotine chloride, Yatrorhizine chloride","[Cl-].COC1=CC2=C(CC[N+]3=CC4=C(C=CC(=C4OC)OC)C=C23)C=C1O",1.262,3,1,3]
["S9087","Tenuifolin","b8","L4700-08","in 10mM DMSO","AChR,Beta Amyloid","Neuronal Signaling","Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.",680.82,"20183-47-5",{"v":100,"d":"100.00"},146.88,null,null,"https://www.selleckchem.com/products/tenuifolin.html","C36H56O12","free base",null,"CC1(C)CCC2(CCC3(CO)C(=CCC4C5(C)CC(O)C(OC6OC(CO)C(O)C(O)C6O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O",1.786,4,6,6]
["S9118","Beta-Asarone","c8","L4700-08","in 10mM DMSO","Others","Others","Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.",208.25,"5273-86-9",null,"The physical form of the compound is liquid, which can be dissolved in any proportion.",null,null,"https://www.selleckchem.com/products/beta-asarone.html","C12H16O3","free base",null,"COC1=CC(=C(\\C=C/C)C=C1OC)OC",2.734,3,0,4]
["S9149","Benzoylpaeoniflorin","d8","L4700-08","in 10mM DMSO","COX","Immunology & Inflammation","Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.",584.57,"38642-49-8",{"v":100,"d":"100.00"},171.07,null,null,"https://www.selleckchem.com/products/benzoylpaeoniflorin.html","C30H32O12",null,null,"CC12CC3(O)OC(O1)C4(COC(=O)C5=CC=CC=C5)C3CC24OC6OC(COC(=O)C7=CC=CC=C7)C(O)C(O)C6O",{"v":0.76,"d":"0.760"},8,3,10]
["S9154","Chelidonine","e8","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Chelidonine (Stylophorin, Helidonine), a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.",353.37,"476-32-4",{"v":5,"d":"5.00"},14.15,null,null,"https://www.selleckchem.com/products/chelidonine.html","C20H19NO5","free base","Stylophorin, Helidonine","CN1CC2=C(C=CC3=C2OCO3)C4C(O)CC5=C(C=C6OCOC6=C5)C14",2.329,4,1,0]
["S9174","Xanthotoxol","f8","L4700-08","in 10mM DMSO","5-HT Receptor,Immunology & Inflammation related","Neuronal Signaling","Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.",202.16,"2009-24-7",{"v":40,"d":"40.00"},197.86,null,null,"https://www.selleckchem.com/products/xanthotoxol.html","C11H6O4","free base","8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen","OC1=C2OC(=O)C=CC2=CC3=C1OC=C3",1.961,3,1,0]
["S9179","Catharanthine hemitartrate","g8","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Catharanthine hemitartrate is the starting material for the synthesis of the antitumor drugs vinblastine and vincristine.",822.94,"4168-17-6",{"v":97,"d":"97.00"},199.38,null,null,"https://www.selleckchem.com/products/catharanthine-hemitartrate.html","C46H54N4O10","free base",null,"CCC1=CC2CN3CCC4=C([NH]C5=C4C=CC=C5)C(C2)(C13)C(=O)OC.OC(C(O)C(O)=O)C(O)=O",-0.822,4,3,6]
["S9190","Oroxin B","h8","L4700-08","in 10mM DMSO","Akt,Apoptosis related,COX,PI3K,PTEN","Apoptosis","Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.",594.52,"114482-86-9",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},null,null,"https://www.selleckchem.com/products/oroxin-b.html","C27H30O15","free base","Hypocretin-2","OCC1OC(OCC2OC(OC3=C(O)C(=C4C(=O)C=C(OC4=C3)C5=CC=CC=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.267,6,9,7]
["S9219","Huperzine B","a9","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.",256.34,"103548-82-9",{"v":10,"d":"10.00"},39.01,null,null,"https://www.selleckchem.com/products/huperzine-b.html","C16H20N2O","free base",null,"CC1=CC2CC3=C(C=CC(=O)N3)C4(C1)NCCCC24",1.259,1,2,0]
["S9236","α-Cyperone","b9","L4700-08","in 10mM DMSO","COX,Interleukins","Immunology & Inflammation","α-Cyperone (alpha-cyperone), a major active compound of Cyperus rotundus, exhibits biological activities, such as antivirulence, antigenotoxic, and antibacterial activities. α-Cyperone (alpha-cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1.",218.33,"473-08-5",null,"The physical form of the compound is liquid, which can be dissolved in any proportion.",null,null,"https://www.selleckchem.com/products/alpha-cyperone.html","C15H22O","free base",null,"CC(=C)C1CCC2(C)CCC(=O)C(=C2C1)C",3.946,1,0,1]
["S9239","Isocorynoxeine","c9","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Isocorynoxeine (7-Isocorynoxeine), a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems. Isocorynoxeine suppress 5-HT2A receptor-mediated current response with IC50 of 72.4 μM.",382.45,"51014-29-0",{"v":77,"d":"77.00"},201.33,null,null,"https://www.selleckchem.com/products/isocorynoxeine.html","C22H26N2O4","free base","7-Isocorynoxeine","CO\\C=C(/C1CC2N(CCC23C(=O)NC4=CC=CC=C34)CC1C=C)C(=O)OC",1.712,4,1,5]
["S9249","Securinine","d9","L4700-08","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.",217.26,"5610-40-2",{"v":44,"d":"44.00"},202.52,null,null,"https://www.selleckchem.com/products/securinine.html","C13H15NO2","free base",null,"O=C1OC23CC(C=CC2=C1)N4CCCCC34",1.449,2,0,0]
["S9252","Corydaline","e9","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.",369.45,"518-69-4",{"v":74,"d":"74.00"},{"v":200.3,"d":"200.30"},null,null,"https://www.selleckchem.com/products/corydaline.html","C22H27NO4","free base",null,"COC1=CC2=C(C=C1OC)C3C(C)C4=C(CN3CC2)C(=C(OC)C=C4)OC",3.918,4,0,4]
["S9258","(+)-Isocorynoline","f9","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Isocorynoxeine, a major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM and shows various beneficial effects, including lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage.",{"v":341.4,"d":"341.40"},"475-67-2",{"v":32,"d":"32.00"},93.73,null,null,"https://www.selleckchem.com/products/isocorynoline.html","C20H23NO4","free base",null,"COC1=C(O)C2=C(CC3N(C)CCC4=C3C2=C(OC)C(=C4)OC)C=C1",3.308,3,1,3]
["S9260","Nodakenin","g9","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.",{"v":408.4,"d":"408.40"},"495-31-8",{"v":82,"d":"82.00"},200.78,null,null,"https://www.selleckchem.com/products/nodakenin.html","C20H24O9","free base","(+)-Marmesinin","CC(C)(OC1OC(CO)C(O)C(O)C1O)C2CC3=CC4=C(OC(=O)C=C4)C=C3O2",0.282,5,4,4]
["S9340","Bz-RS-ISer(3-Ph)-Ome","h9","L4700-08","in 10mM DMSO","Others","Others","Bz-RS-ISer(3-Ph)-Ome is a chemical.",299.32,"32981-85-4",{"v":59,"d":"59.00"},197.11,null,null,"https://www.selleckchem.com/products/bz-rs-iser-3-ph-ome.html","C17H17NO4","free base",null,"COC(=O)C(O)C(NC(=O)C1=CC=CC=C1)C2=CC=CC=C2",1.953,3,2,6]
["S9395","N-Benzoyl-(2R,3S)-3-phenylisoserine","a10","L4700-08","in 10mM DMSO","Others","Others","N-Benzoyl-(2R,3S)-3-phenylisoserine, also known as taxol side chain, is important for strong antitumor activity of taxol.",285.29,"132201-33-3",{"v":57,"d":"57.00"},199.79,null,null,"https://www.selleckchem.com/products/n-benzoyl-2r-3s-3-phenylisoserine.html","C16H15NO4","free base","taxol side chain","OC(C(NC(=O)C1=CC=CC=C1)C2=CC=CC=C2)C(O)=O",1.727,2,2,5]
["S9409","Kavain","b10","L4700-08","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Kavain ((+)-Kavain), the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor.",230.26,"500-64-1",{"v":46,"d":"46.00"},199.77,null,null,"https://www.selleckchem.com/products/kavain.html","C14H14O3","free base","(+)-Kavain","COC1=CC(=O)OC(C1)\\C=C\\C2=CC=CC=C2",2.218,3,0,3]
["S9459","Mecamylamine Hydrochloride","c10","L4700-08","in 10mM DMSO","AChR","Neuronal Signaling","Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.",203.75,"826-39-1",{"v":41,"d":"41.00"},201.23,{"v":-1,"d":"-1.00"},null,"N/A","C11H21N · HCl","Hydrochloride","N/A","Cl.CNC1(C)C2CCC(C2)C1(C)C",2.565,0,1,1]
["S9502","Madecassic acid","d10","L4700-08","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.",{"v":504.7,"d":"504.70"},"18449-41-7",{"v":100,"d":"100.00"},198.13,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/madecassic-acid.html","C30H48O6","Free Base","Brahmic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(O)=O",3.265,1,4,2]
["S9510","Protriptyline hydrochloride","e10","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake.",299.84,"1225-55-4",{"v":60,"d":"60.00"},200.11,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/protriptyline-hydrochloride.html","C19H22ClN","hydrochloride","N/A","Cl.CNCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",4.423,0,1,4]
["S9560","Anisodamine Hydrobromide","f10","L4700-08","in 10mM DMSO","AChR,Adrenergic Receptor,Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).",386.28,"55449-49-5",{"v":77,"d":"77.00"},199.34,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/anisodamine-hydrobromide.html","C17H24BrNO4","Hydrobromide","6-Hydroxyhyoscyamine","Br.CN1C2CC(O)C1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",1.121,2,2,5]
["S2934","Ensartinib (X-396) dihydrochloride","g10","L4700-08","in 10mM DMSO","ALK","Angiogenesis","Ensartinib (X-396) is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.",634.36,"2137030-98-7",{"v":100,"d":"100.00"},157.64,{"v":27,"d":"27.00"},42.56,"http://www.selleck.cn/products/ensartinib-dihydrochloride.html","C26H29Cl4FN6O3","Dihydrochloride","N/A","Cl.Cl.CC1CN(CC(C)N1)C(=O)C2=CC=C(NC(=O)C3=NN=C(N)C(=C3)OC(C)C4=C(Cl)C(=CC=C4Cl)F)C=C2",5.051,5,3,6]
["S6712","S107","h10","L4700-08","in 10mM DMSO","Others","Others","S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1.",209.31,"927871-76-9",{"v":42,"d":"42.00"},200.66,"<1",null,"http://www.selleck.cn/products/s107.html","C11H15NOS","Free Base","N/A","COC1=CC=C2SCCN(C)CC2=C1",2.247,1,0,1]
["S8874","PLX5622","a11","L4700-08","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.",395.41,"1303420-67-8",{"v":79,"d":"79.00"},199.79,"<1",null,"http://www.selleck.cn/products/plx5622.html","C21H19F2N5O","Free Base","N/A","COC1=C(CNC2=NC(=C(CC3=C[NH]C4=NC=C(C)C=C34)C=C2)F)C=C(F)C=N1",4.577,4,2,6]
["S9183","Ruscogenin","b11","L4700-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities.",430.62,"472-11-7",{"v":86,"d":"86.00"},199.71,null,null,"https://www.selleckchem.com/products/ruscogenin.html","C27H42O4","free base",null,"CC1CCC2(OC1)OC3CC4C5CC=C6CC(O)CC(O)C6(C)C5CCC4(C)C3C2C",3.408,2,2,0]
["S9138","Picfeltarraenin IA","c11","L4700-08","in 10mM DMSO","AChR,Complement System","Neuronal Signaling","Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.",762.92,"97230-47-2",{"v":100,"d":"100.00"},131.07,null,null,"https://www.selleckchem.com/products/picfeltarraenin-ia.html","C41H62O13","free base",null,"CC(C)C1=CC(=O)C(C)(O1)C2C(O)CC3(C)C4CC=C5C(CCC(OC6OCC(O)C(O)C6OC7OC(C)C(O)C(O)C7O)C5(C)C)C4(C)C(=O)CC23C",{"v":1.72,"d":"1.720"},7,6,6]
["S2272","Indoprofen","d11","L4700-08","in 10mM DMSO","COX,Others,PDPK1","PI3K/Akt/mTOR","Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein.",281.31,"31842-01-0",{"v":52,"d":"52.00"},184.85,"<1",null,"http://www.selleck.cn/products/indoprofen.html","C17H15NO3","Free Base","N/A","CC(C(O)=O)C1=CC=C(C=C1)N2CC3=C(C=CC=C3)C2=O",2.701,2,0,3]
["S2644","Lerisetron","e11","L4700-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.",292.38,"143257-98-1",{"v":58,"d":"58.00"},198.37,"<1",null,"http://www.selleck.cn/products/lerisetron.html","C18H20N4","Free Base","F 0930, F 0930RS","C1CN(CCN1)C2=NC3=C(C=CC=C3)[N]2CC4=CC=CC=C4",{"v":3.26,"d":"3.260"},1,1,3]
["S6674","Cytosporone B","f11","L4700-08","in 10mM DMSO","Nur77","Cell Cycle","Cytosporone B  is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.",{"v":322.4,"d":"322.40"},"321661-62-5",{"v":64,"d":"64.00"},198.51,"<1",null,"http://www.selleck.cn/products/cytosporone-b.html","C18H26O5","Free Base","N/A","CCCCCCCC(=O)C1=C(O)C=C(O)C=C1CC(=O)OCC",4.272,3,2,11]
["S6676","Ebselen","g11","L4700-08","in 10mM DMSO","COVID-19,HIV","Microbiology","Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.",274.18,"60940-34-3",{"v":55,"d":"55.00"},{"v":200.6,"d":"200.60"},"<1",null,"http://www.selleck.cn/products/ebselen.html","C13H9NOSe","Free Base","DR 3305, SPI-1005, PZ-51, CCG-39161","O=C1N([Se]C2=C1C=CC=C2)C3=CC=CC=C3",3.227,1,0,1]
["S6680","L-779450","h11","L4700-08","in 10mM DMSO","Raf","MAPK","L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM.",{"v":347.8,"d":"347.80"},"303727-31-3",{"v":70,"d":"70.00"},201.27,"<1",null,"http://www.selleck.cn/products/l-779450.html","C20H14ClN3O","Free Base","L-779,450","OC1=CC(=CC=C1Cl)C2=C(N=C([NH]2)C3=CC=CC=C3)C4=CC=NC=C4",{"v":4.67,"d":"4.670"},2,2,3]
["S6684","IOX4","a2","L4700-09","in 10mM DMSO","HIF","Angiogenesis","IOX4 is a potent and selective  HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines.",328.33,"1154097-71-8",{"v":66,"d":"66.00"},201.02,"<1",null,"http://www.selleck.cn/products/iox4.html","C15H16N6O3","Free Base","N/A","CC(C)(C)OC(=O)C1=CC=C(N=C1)N2NC=C([N]3C=CN=N3)C2=O",0.137,6,1,5]
["S8949","Olutasidenib (FT-2102)","b2","L4700-09","in 10mM DMSO","Dehydrogenase","Metabolism","Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively.",354.79,"1887014-12-1",{"v":71,"d":"71.00"},200.12,"<1",null,"http://www.selleck.cn/products/olutasidenib-ft-2102.html","C18H15ClN4O2","Free Base","N/A","CC(NC1=CC=C(C#N)N(C)C1=O)C2=CC3=C(NC2=O)C=CC(=C3)Cl",1.234,2,2,3]
["S0222","Lvguidingan","c2","L4700-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Lvguidingan (Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide) is an anticonvulsant/antiepileptic agent. Lvguidingan (Anticonvulsant 7903) is found to be able to increase the concentration of 5-HT and 5-HIAA in mice brain.",272.17,"82351-05-1",{"v":54,"d":"54.00"},198.41,"˂1",null,"http://www.selleckchem.com/products/lvguidingan.html","C13H15Cl2NO","Free Base","Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide","CCC(C)NC(=O)\\C=C\\C1=CC(=C(Cl)C=C1)Cl",4.084,1,1,4]
["S0287","P7C3-A20","d2","L4700-09","in 10mM DMSO","Others","Others","P7C3-A20 is a highly active analogue of P7C3. P7C3-A20 is neuroprotective and promotes endogenous reparative strategies after TBI (Traumatic brain injury).",506.21,"1235481-90-9",{"v":100,"d":"100.00"},197.55,"˂1",null,"http://www.selleckchem.com/products/p7c3-a20.html","C22H19Br2FN2O","Free Base","N/A","COC1=CC(=CC=C1)NCC(F)C[N]2C3=C(C=C(Br)C=C3)C4=C2C=CC(=C4)Br",6.896,1,1,6]
["S0528","Raphin1","e2","L4700-09","in 10mM DMSO","phosphatase","Metabolism","Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.",231.08,"2022961-17-5",{"v":46,"d":"46.00"},199.07,"˂1",null,"http://www.selleckchem.com/products/raphin1.html","C8H8Cl2N4","Free Base","N/A","NC(=N)N\\N=C\\C1=C(Cl)C(=CC=C1)Cl",2.192,1,2,3]
["S0779","Pirenperone","f2","L4700-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).",393.45,"75444-65-4",{"v":17,"d":"17.00"},43.21,"<1",null,"http://www.selleckchem.com/products/pirenperone.html","C23H24FN3O2","Free Base","R-47456, R-50656","CC1=C(CCN2CCC(CC2)C(=O)C3=CC=C(F)C=C3)C(=O)N4C=CC=CC4=N1",2.711,3,0,5]
["S2121","Licofelone (ML3000)","g2","L4700-09","in 10mM DMSO","COX","Neuronal Signaling","Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.",379.88,"156897-06-2",{"v":19,"d":"19.00"},50.02,"<1",null,"http://www.selleckchem.com/products/licofelone.html","C23H22ClNO2","Free Base","ML3000","CC1(C)C[N]2C(=C(C3=CC=C(Cl)C=C3)C(=C2C1)C4=CC=CC=C4)CC(O)=O",{"v":5.78,"d":"5.780"},1,0,4]
["S2578","1-Phenylbiguanide","h2","L4700-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.",177.21,"102-02-3",{"v":35,"d":"35.00"},197.51,{"v":35,"d":"35.00"},197.51,"http://www.selleckchem.com/products/1-phenylbiguanide.html","C8H11N5","Free Base","Phenylbiguanide, PBG, N-Phenylbiguanide","NC(=N)NC(=N)NC1=CC=CC=C1",0.629,0,3,4]
["S2595","FK-3311","a3","L4700-09","in 10mM DMSO","COX","Immunology & Inflammation","FK-3311 (COX-2 Inhibitor V) is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.",341.33,"116686-15-8",{"v":68,"d":"68.00"},199.22,"<1",null,"http://www.selleckchem.com/products/fk-3311.html","C15H13F2NO4S","Free Base","COX-2 Inhibitor V","CC(=O)C1=CC=C(N[S](C)(=O)=O)C(=C1)OC2=CC=C(F)C=C2F",2.452,4,1,5]
["S2646","VU0238429","b3","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","VU0238429 (M5 PAM) is the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5/M5) with EC50 of 1.16 μM at M5 and both > 30 μM at M1 and M3. VU0238429 shows no potentiator activity at M2 or M4.",351.28,"1160247-92-6",{"v":70,"d":"70.00"},199.27,"<1",null,"http://www.selleckchem.com/products/vu0238429.html","C17H12F3NO4","Free Base","M5 PAM","COC1=CC=C(CN2C(=O)C(=O)C3=C2C=CC(=C3)OC(F)(F)F)C=C1",4.563,4,0,5]
["S2649","SB 200646","c3","L4700-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.",{"v":266.3,"d":"266.30"},"143797-63-1",{"v":53,"d":"53.00"},199.02,"˂1",null,"http://www.selleckchem.com/products/sb-200646.html","C15H14N4O","Free Base","SB 200646A","C[N]1C=CC2=C1C=CC(=C2)NC(=O)NC3=CC=CN=C3",1.871,2,2,2]
["S6559","ML-297","d3","L4700-09","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","ML-297 (VU 0456810, CID 56642816) is a potent and selective activator of Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) channel with EC50 of 0.16 μM and 1.8 μM for GIRK1/2 and GIRK1/4, respectively. ML-297 is potential for the treatment of epilepsy.",328.32,"1443246-62-5",{"v":66,"d":"66.00"},201.02,"<1",null,"http://www.selleckchem.com/products/ml297.html","C17H14F2N4O","Free Base","VU 0456810, CID 56642816","CC1=N[N](C(=C1)NC(=O)NC2=CC(=C(F)C=C2)F)C3=CC=CC=C3",3.567,2,2,3]
["S6615","ATB 346","e3","L4700-09","in 10mM DMSO","Apoptosis related,COX,Others","Immunology & Inflammation","ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.",365.45,"1226895-20-0",{"v":73,"d":"73.00"},199.75,"<1",null,"http://www.selleckchem.com/products/atb-346.html","C21H19NO3S","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(=O)OC3=CC=C(C=C3)C(N)=S",4.521,3,1,6]
["S6685","Mavacoxib","f3","L4700-09","in 10mM DMSO","COX","Immunology & Inflammation","Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).",385.34,"170569-88-7",{"v":77,"d":"77.00"},199.82,"<1",null,"http://www.selleckchem.com/products/mavacoxib.html","C16H11F4N3O2S","Free Base","Trocoxil","N[S](=O)(=O)C1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(F)C=C3)C(F)(F)F",4.147,3,1,4]
["S6686","SC-560","g3","L4700-09","in 10mM DMSO","COX","Immunology & Inflammation","SC-560 is a highly selective COX-1 inhibitor with IC50 of 9 nM, compared with the IC50 of 6.3 μM for COX-2, nearly 1,000-fold higher than with COX-1.",352.74,"188817-13-2",{"v":70,"d":"70.00"},198.45,"<1",null,"http://www.selleckchem.com/products/sc-560.html","C17H12ClF3N2O","Free Base","N/A","COC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(Cl)C=C3)C(F)(F)F",5.885,2,0,4]
["S6780","TFAP","h3","L4700-09","in 10mM DMSO","COX","Immunology & Inflammation","TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective and cell-permeable cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.",281.23,"1011244-68-0",{"v":56,"d":"56.00"},199.13,"<1",null,"http://www.selleckchem.com/products/tfap.html","C13H10F3N3O","Free Base","N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide","NC1=CN=C(NC(=O)C2=CC=C(C=C2)C(F)(F)F)C=C1",2.198,2,2,3]
["S6782","Anle138b","a4","L4700-09","in 10mM DMSO","Others","Neuronal Signaling","Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.",343.17,"882697-00-9",{"v":69,"d":"69.00"},201.07,"<1",null,"http://www.selleckchem.com/products/anle138b.html","C16H11BrN2O2","Free Base","N/A","BrC1=CC(=CC=C1)C2=CC(=N[NH]2)C3=CC=C4OCOC4=C3",4.547,3,1,2]
["S6793","TG4-155","b4","L4700-09","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","TG4-155 is a potent and selective Prostaglandin Receptor EP2(PTGER2) antagonist with Ki value of 9.9 nM.",394.46,"1164462-05-8",{"v":79,"d":"79.00"},200.27,"<1",null,"http://www.selleckchem.com/products/tg4-155.html","C23H26N2O4","Free Base","N/A","COC1=C(OC)C(=CC(=C1)/C=C/C(=O)NCC[N]2C(=CC3=C2C=CC=C3)C)OC",{"v":3.75,"d":"3.750"},4,1,8]
["S6795","VU0357017 Hydrochloride","c4","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.",369.89,"1135242-13-5",{"v":38,"d":"38.00"},102.73,{"v":10,"d":"10.00"},27.04,"http://www.selleckchem.com/products/vu0357017-hydrochloride.html","C18H28ClN3O3","Hydrochloride","CID-25010775","Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C",1.871,3,2,7]
["S8784","PQR620","d4","L4700-09","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.",445.47,"1927857-56-4",{"v":20,"d":"20.00"},{"v":44.9,"d":"44.90"},"˂1",null,"http://www.selleckchem.com/products/pqr620.html","C21H25F2N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3C4CCC3COC4)N5C6CCC5COC6)C(=C1)C(F)F",2.434,6,1,4]
["S0016","SN-6","e4","L4700-09","in 10mM DMSO","AChR,Calcium Channel,NCX,Sodium Channel","Transmembrane Transporters","SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.",402.46,"415697-08-4",{"v":80,"d":"80.00"},198.78,"<1",null,"http://www.selleckchem.com/products/sn-6.html","C20H22N2O5S","free base","N/A","CCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1",3.715,3,1,9]
["S0022","YF-2","f4","L4700-09","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","YF-2 is a highly selective, blood-brain-barrier permeable activator of histone acetyltransferase (HAT). In In vitro assays, YF-2 has activity versus CBP, PCAF, and GCN5 with EC50 of 2.75 μΜ, 29.04 μΜ and 49.3 μΜ, respectively. YF-2 also increases p300 activity.",430.85,"1311423-89-8",{"v":86,"d":"86.00"},199.61,{"v":86,"d":"86.00"},199.61,"http://www.selleckchem.com/products/yf-2.html","C20H22ClF3N2O3","free base","N/A","CCOC1=C(C(=O)NC2=CC(=C(Cl)C=C2)C(F)(F)F)C(=CC=C1)OCCN(C)C",4.676,3,1,9]
["S0457","DREADD agonist 21","g4","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (hM3Dq) with EC50 of 1.7 nM.",278.35,"56296-18-5",{"v":56,"d":"56.00"},201.19,"<1",null,"http://www.selleckchem.com/products/dreadd-agonist-21.html","C17H18N4","free base","N/A","C1CN(CCN1)C2=NC3=CC=CC=C3NC4=CC=CC=C24",2.222,1,2,1]
["S0744","Raphin1 acetate","h4","L4700-09","in 10mM DMSO","phosphatase","Metabolism","Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.",291.13,"2242616-04-0",{"v":58,"d":"58.00"},199.22,"<1",null,"http://www.selleckchem.com/products/raphin1-acetate.html","C10H12Cl2N4O2","acetate","N/A","CC(O)=O.NC(=N)N\\N=C\\C1=C(Cl)C(=CC=C1)Cl",1.987,2,2,3]
["S3245","Nodakenetin","a5","L4700-09","in 10mM DMSO","AChR,Aldose Reductase,Apoptosis related,BACE,BChE,Bcl-2,Carbohydrate Metabolism,phosphatase","Metabolism","Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.",246.26,"495-32-9",{"v":100,"d":"100.00"},406.07,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/nodakenetin.html","C14H14O4","free base","NANI","CC(C)(O)C1CC2=C(O1)C=C3OC(=O)C=CC3=C2",2.029,3,0,1]
["S3246","Picfeltarraenin IB","b5","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","Picfeltarraenin IB, a cucurbitacin glycoside isolated from Picriafel-terrae, is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.",792.95,"97230-46-1",{"v":100,"d":"100.00"},126.11,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/picfeltarraenin-ib.html","C42H64O14","free base","N/A","CC(C)C1=CC(=O)C(CO1)C2C(O)CC3(C)C4CC=C5C(CCC(OC6OC(CO)C(O)C(O)C6OC7OC(C)C(O)C(O)C7O)C5(C)C)C4(C)C(=O)CC23C",1.051,7,7,7]
["S3255","Pectolinarigenin","c5","L4700-09","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).",314.29,"520-12-7",{"v":100,"d":"100.00"},318.18,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/pectolinarigenin.html","C17H14O6","free base","N/A","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O)C(=C(O)C=C3O2)OC",2.619,4,2,3]
["S3261","Myrislignan","d5","L4700-09","in 10mM DMSO","Anti-infection,COX,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.",374.43,"171485-39-5",{"v":100,"d":"100.00"},267.07,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/myrislignan.html","C21H26O6","free base","N/A","COC1=C(O)C=CC(=C1)C(O)C(C)OC2=C(OC)C=C(CC=C)C=C2OC",{"v":3.98,"d":"3.980"},4,2,9]
["S3283","Marmesin","e5","L4700-09","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.",246.26,"13849-08-6",{"v":100,"d":"100.00"},406.07,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/marmesin.html","C14H14O4","free base","S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin","CC(C)(O)C1CC2=CC3=C(OC(=O)C=C3)C=C2O1",2.029,3,0,1]
["S3298","Caulophylline (N-Methylcytisine)","f5","L4700-09","in 10mM DMSO","AChR,IκB/IKK,NF-κB,Peroxidases","Neuronal Signaling","Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.",204.27,"486-86-2 (63699-79-6, 207-643-8)",{"v":100,"d":"100.00"},489.55,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/caulophylline-n-methylcytisine-.html","C12H16N2O","free base","Caulophyllin, NMC","CN1CC2CC(C1)C3=CC=CC(=O)N3C2",0.198,1,0,0]
["S6762","Bozitinib (PLB-1001)","g5","L4700-09","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.",424.38,"1440964-89-5",{"v":85,"d":"85.00"},200.29,"<1",null,"http://www.selleckchem.com/products/bozitinib.html","C20H15F3N8","free base","CBT-101, APL-101, CBI-3103","C[N]1C=C2C=C(C(=CC2=N1)F)C(F)(F)C3=NN=C4C=CC(=N[N]34)C5=C[N](N=C5)C6CC6",3.548,5,0,4]
["S6850","NE 52-QQ57","h5","L4700-09","in 10mM DMSO","cAMP,COX,GPR,Interleukins,NOS,PGES,TNF-alpha","GPCR & G Protein","NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).",416.52,"1401728-56-0",{"v":20,"d":"20.00"},48.02,"<1",null,"http://www.selleckchem.com/products/ne-52-qq57.html","C24H28N6O","free base","N/A","CCC1=N[N]2C(=CC(=NC2=C1CC3=CC=C(C=C3)C4=NN=C(O4)C5CCNCC5)C)C",3.242,5,1,5]
["S6906","Capric acid","a6","L4700-09","in 10mM DMSO","GluR,PPAR","Neuronal Signaling","Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.",172.26,"334-48-5",{"v":34,"d":"34.00"},197.38,{"v":34,"d":"34.00"},197.38,"http://www.selleckchem.com/products/capric-acid.html","C10H20O2","free base","DA, Decanoic acid, Decylic acid","CCCCCCCCCC(O)=O",3.655,1,0,8]
["S7394","MDL-28170","b6","L4700-09","in 10mM DMSO","Cysteine Protease","Proteases","MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase.",382.45,"88191-84-8",{"v":76,"d":"76.00"},198.72,"<1",null,"http://www.selleckchem.com/products/mdl-28170.html","C22H26N2O4","free base","Calpain Inhibitor III","CC(C)C(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C=O",3.531,4,2,10]
["S9662","UNC2025","c6","L4700-09","in 10mM DMSO","Axl,c-Kit,c-Met,FLT3,Mertk,Trk receptor,Tyro3","Protein Tyrosine Kinase","UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively.",476.66,"1429881-91-3",{"v":100,"d":"100.00"},209.79,"<1",null,"http://www.selleckchem.com/products/unc2025.html","C28H40N6O","free base","N/A","CCCCNC1=NC=C2C(=N1)[N](C=C2C3=CC=C(CN4CCN(C)CC4)C=C3)C5CCC(O)CC5",4.578,2,2,8]
["S0496","PF-04995274","d6","L4700-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.",432.51,"1331782-27-4",{"v":86,"d":"86.00"},198.84,"<1",null,"https://www.selleckchem.com/products/pf-04995274.html","C23H32N2O6","Free Base","PF-4995274","OC1(CCOCC1)CN2CCC(CC2)COC3=NOC4=C3C(=CC=C4)OC5CCOC5",1.615,6,0,7]
["S0552","BNC210","e6","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).",317.38,"13589-06-5",{"v":63,"d":"63.00"},{"v":198.5,"d":"198.50"},"<1",null,"https://www.selleckchem.com/products/bnc210.html","C17H23N3O3","Free Base","H-Ile-Trp-OH, IW-2143","CCC(C)C(N)C(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(O)=O",-0.469,2,3,7]
["S0759","FPL 62064","f6","L4700-09","in 10mM DMSO","COX,Lipoxygenase","Metabolism","FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.",265.31,"103141-09-9",{"v":53,"d":"53.00"},199.77,"<1",null,"https://www.selleckchem.com/products/fpl-62064.html","C16H15N3O","Free Base","N/A","COC1=CC=C(NC2=N[N](C=C2)C3=CC=CC=C3)C=C1",4.129,2,1,4]
["S0766","RHC 80267","g6","L4700-09","in 10mM DMSO","AChR,COX,Phospholipase (e.g. PLA)","Neuronal Signaling","RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).",394.51,"83654-05-1",{"v":79,"d":"79.00"},200.25,"<1",null,"https://www.selleckchem.com/products/rhc-80267.html","C20H34N4O4","Free Base","U-57908","O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C2CCCCC2",3.775,6,2,11]
["S0782","VU0238441","h6","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50 of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and >10 μM for M5, M3, M2, M1 and M4, respectively.",{"v":339.7,"d":"339.70"},"85511-68-8",{"v":50,"d":"50.00"},147.19,"<1",null,"https://www.selleckchem.com/products/vu0238441.html","C16H9ClF3NO2","Free Base","N/A","FC(F)(F)C1=CC=C(CN2C(=O)C(=O)C3=C2C(=CC=C3)Cl)C=C1",4.066,2,0,3]
["S0783","VU0119498","a7","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","VU0119498 is a pan Gq muscarinic acetylcholine receptor (mAChR) M1, M3, M5 positive allosteric modulator (PAM) with EC50 of 6.1 μM, 6.4 μM, 4.1 μM, respectively.",316.15,"79183-37-2",{"v":50,"d":"50.00"},158.15,"<1",null,"https://www.selleckchem.com/products/vu0119498.html","C15H10BrNO2","Free Base","N/A","BrC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1",3.208,2,0,2]
["S0798","PZ-2891","b7","L4700-09","in 10mM DMSO","Others","Metabolism","PZ-2891 is a selective, orally active and brain-penetrant pantothenate kinase (PANK) modulator that acts as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits PANK with IC50 of  40.2 nM, 0.7 nM and 1.3 nM for hPANK1β, hPANK2, and hPANK3, respectively.",349.43,"2170608-82-7",{"v":70,"d":"70.00"},200.33,"<1",null,"https://www.selleckchem.com/products/pz-2891.html","C20H23N5O","Free Base","N/A","CC(C)C1=CC=C(CC(=O)N2CCN(CC2)C3=NN=C(C=C3)C#N)C=C1",{"v":3.33,"d":"3.330"},3,0,4]
["S1198","Irinotecan (CPT-11)","c7","L4700-09","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11, (+)-Irinotecan) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.",586.68,"97682-44-5",{"v":51,"d":"51.00"},86.93,"<1",null,"https://www.selleckchem.com/products/Irinotecan-cpt-11.html","C33H38N4O6","Free Base","(+)-Irinotecan,CPT-11","CCC1=C2C=C(OC(=O)N3CCC(CC3)N4CCCCC4)C=CC2=NC5=C1CN6C(=O)C7=C(C=C56)C(O)(CC)C(=O)OC7",3.686,6,0,5]
["S3311","Myosmine","d7","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","Myosmine is not only one of the minor tobacco alkaloids but is also present in various foods. Myosmine has low affinity against a4b2 nicotinic acetylcholinergic receptors (nAChR) with Ki of 3300 nM.",146.19,"532-12-7",{"v":29,"d":"29.00"},198.37,{"v":29,"d":"29.00"},198.37,"https://www.selleckchem.com/products/myosmine.html","C9H10N2","Free Base","N/A","C1CN=C(C1)C2=CN=CC=C2",0.935,2,0,1]
["S3329","(L)-Dehydroascorbic acid","e7","L4700-09","in 10mM DMSO","Others","Others","(L)-Dehydroascorbic acid (DHA) is an oxidized form of l-Ascorbic acid (AsA) that efficiently scavenges non-thermal plasma-induced hydroxyl radicals in the presence of thiols and fails to scavenge hydroxyl radicals by itself.",174.11,"490-83-5",{"v":35,"d":"35.00"},201.02,"<1",null,"https://www.selleckchem.com/products/l-dehydroascorbic-acid.html","C6H6O6","Free Base","DHA","OCC(O)C1OC(=O)C(=O)C1=O",-1.456,4,2,2]
["S6959","Perhexiline maleate","f7","L4700-09","in 10mM DMSO","CPT","Metabolism","Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1) with IC50s of 77 μM and 148 μM for rat heart CPT1 and liver CPT1, respectively, and also inhibits carnitine palmitoyltransferase 2 (CPT2).",393.56,"6724-53-4",{"v":78,"d":"78.00"},198.19,"<1",null,"https://www.selleckchem.com/products/perhexiline-maleate.html","C23H39NO4","Maleate","N/A","OC(=O)\\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3",3.054,2,1,6]
["S8919","LY-3381916","g7","L4700-09","in 10mM DMSO","IDO/TDO","Metabolism","LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.",396.45,"2166616-75-5",{"v":79,"d":"79.00"},199.27,"<1",null,"https://www.selleckchem.com/products/ly-3381916.html","C23H25FN2O3","Free Base","IDO1-IN-5","CC(NC(=O)C1=CC=C(F)C=C1)C2=CC=C3N(CCC3=C2)C(=O)C4CCOCC4",2.962,3,1,4]
["S8930","MCC950","h7","L4700-09","in 10mM DMSO","NLRP3","Immunology & Inflammation","MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.",404.48,"210826-40-7",{"v":81,"d":"81.00"},200.26,"<1",null,"https://www.selleckchem.com/products/mcc950.html","C20H24N2O5S","Free Base","CP-456773, CRID3","CC(C)(O)C1=COC(=C1)[S](=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4",3.418,4,2,4]
["S9029","Prim-o-glucosylcimifugin","a8","L4700-09","in 10mM DMSO","COX,NOS","Immunology & Inflammation","Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.",468.45,"80681-45-4",{"v":94,"d":"94.00"},200.66,{"v":94,"d":"94.00"},200.66,"https://www.selleckchem.com/products/prim-o-glucosylcimifugin.html","C22H28O11","Free Base","Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside","COC1=C2CC(OC2=CC3=C1C(=O)C=C(COC4OC(CO)C(O)C(O)C4O)O3)C(C)(C)O",{"v":-0.62,"d":"-0.620"},6,4,6]
["S9208","Ginsenoside Rb3","b8","L4700-09","in 10mM DMSO","COX,NF-κB,NOS","NF-κB","Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL).",1079.27,"68406-26-8",{"v":100,"d":"100.00"},92.66,{"v":-1,"d":"-1.00"},null,"https://www.selleckchem.com/products/ginsenoside-rb3.html","C53H90O22","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-0.688,8,14,15]
["S9386","Polygalacic acid","c8","L4700-09","in 10mM DMSO","COX,MMP","Proteases","Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.",{"v":504.7,"d":"504.70"},"22338-71-2",{"v":100,"d":"100.00"},198.14,{"v":-1,"d":"-1.00"},null,"https://www.selleckchem.com/products/polygalacic-acid.html","C30H48O6","Free Base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1)C(O)=O",3.287,1,4,2]
["S4713","Atropine","d8","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.",289.37,"51-55-8",{"v":58,"d":"58.00"},200.44,"<1",null,"http://www.selleckchem.com/products/atropine.html","C17H23NO3","Free Base","N/A","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",1.721,2,1,5]
["S5187","Ribociclib hydrochloride","e8","L4700-09","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) hydrochloride is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.",{"v":471,"d":"471.00"},"1211443-80-9",{"v":94,"d":"94.00"},199.58,{"v":94,"d":"94.00"},199.58,"http://www.selleckchem.com/products/ribociclib-hydrochloride.html","C23H31ClN8O","Hydrochloride","LEE011 hydrochloride","Cl.CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",3.282,4,2,5]
["S5188","Ribociclib succinate","f8","L4700-09","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) succinate (Kisqali) is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.",552.63,"1374639-75-4",{"v":100,"d":"100.00"},180.95,"<1",null,"http://www.selleckchem.com/products/ribociclib-succinate.html","C27H36N8O5","Succinate","LEE011 succinate, Kisqali","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5.OC(=O)CCC(O)=O",-0.164,6,2,8]
["S5192","S-(+)-Ketoprofen","g8","L4700-09","in 10mM DMSO","COX","Immunology & Inflammation","S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.",254.28,"22161-81-5",{"v":51,"d":"51.00"},200.57,"<1",null,"http://www.selleckchem.com/products/s-ketoprofen.html","C16H14O3","Free Base","Actron, (S)-Ketoprofen, Dexketoprofen","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S5957","Vardenafil hydrochloride","h8","L4700-09","in 10mM DMSO","PDE","Metabolism","Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.",525.06,"224785-91-5",{"v":100,"d":"100.00"},190.45,{"v":100,"d":"100.00"},190.45,"http://www.selleckchem.com/products/vardenafil-hydrochloride.html","C23H33ClN6O4S","Hydrochloride","BAY38-9456, Levitra, Staxyn","Cl.CCCC1=NC(=C2[N]1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S](=O)(=O)N4CCN(CC)CC4)C",{"v":2.73,"d":"2.730"},6,1,8]
["S5958","Metformin","a9","L4700-09","in 10mM DMSO","AMPK,Apoptosis related,JNK,Mitophagy,p38 MAPK","PI3K/Akt/mTOR","Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",129.16,"657-24-9",{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},"http://www.selleckchem.com/products/metformin.html","C4H11N5","Free Base","1,1-Dimethylbiguanide","CN(C)C(=N)NC(N)=N",-0.742,0,2,3]
["S5965","Urapidil","b9","L4700-09","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor","Neuronal Signaling","Urapidil is an antihypertensive drug acting as an α1 adrenoreceptor antagonist and a 5-HT1A agonist.",387.48,"34661-75-1",{"v":77,"d":"77.00"},198.72,"<1",null,"http://www.selleckchem.com/products/urapidil.html","C20H29N5O3","Free Base","N/A","COC1=CC=CC=C1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2",1.426,3,1,7]
["S9789","JHU37152","c9","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","JHU37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.",358.84,"2369979-67-7",{"v":72,"d":"72.00"},200.65,"<1",null,"http://www.selleckchem.com/products/jhu37152.html","C19H20ClFN4","Free Base","N/A","CCN1CCN(CC1)C2=NC3=CC(=CC=C3NC4=CC=CC(=C24)F)Cl",3.977,1,1,2]
["S9790","JHU37160","d9","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","JHU37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.",358.84,"2369979-68-8",{"v":72,"d":"72.00"},200.65,"<1",null,"http://www.selleckchem.com/products/jhu37160.html","C19H20ClFN4","Free Base","N/A","CCN1CCN(CC1)C2=NC3=CC(=CC=C3NC4=C2C=CC=C4F)Cl",3.977,1,1,2]
["S0838","S-(4-Nitrobenzyl)-6-thioinosine (NBMPR)","e9","L4700-09","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","S-(4-Nitrobenzyl)-6-thioinosine (NBMPR, Nitrobenzylthioinosine, NBTI, NSC 296962) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.",419.41,"38048-32-7",{"v":84,"d":"84.00"},200.28,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/nbmpr.html","C17H17N5O6S","Free Base","Nitrobenzylthioinosine, NBTI, NSC 296962","OCC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3SCC4=CC=C(C=C4)[N+]([O-])=O",0.885,4,3,6]
["S5899","(R)-(-)-Ibuprofen","f9","L4700-09","in 10mM DMSO","NF-κB","NF-κB","(R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM, and exerts anti-inflammatory and antinociceptive effects.",206.28,"51146-57-7",{"v":41,"d":"41.00"},198.76,{"v":41,"d":"41.00"},198.76,"http://www.selleckchem.com/products/-r-ibuprofen.html","C13H18O2","Free Base","(R)-Ibuprofen","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S6387","Cilengitide","g9","L4700-09","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.",588.66,"188968-51-6",{"v":100,"d":"100.00"},169.88,{"v":100,"d":"100.00"},169.88,"http://www.selleckchem.com/products/cilengitide.html","C27H40N8O7","Free Base","EMD 121974, EMD-12192, EMD-85189, NSC-​707544","CC(C)C1N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O",-1.448,6,6,10]
["E0138","YQ128","h9","L4700-09","in 10mM DMSO","NLRP3","Immunology & Inflammation","YQ128 is a selective inhibitor of NLRP3 with an IC50 of 0.30 &micro;M.",545.11,"2454246-18-3",{"v":100,"d":"100.00"},183.45,"<1",null,"http://www.selleckchem.com/products/yq128.html","C27H29ClN2O4S2","Free Base","N/A","CCCOC1=C(CN(CCC2=CC=C(C=C2)[S](=O)(=O)NCC#C)C(=O)CC3=CSC=C3)C=C(Cl)C=C1",{"v":6.05,"d":"6.050"},4,1,13]
["S0007","RO 5028442 (RG7713)","a10","L4700-09","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","RO 5028442 (RG7713) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM for hV1a and 39 nM for mV1a.",437.96,"920022-47-5",{"v":5,"d":"5.00"},11.42,"<1",null,"http://www.selleckchem.com/products/ro-5028442-rg7713.html","C25H28ClN3O2","free base","N/A","CN(C)CC[N]1C=C(C(=O)N2CCC3(CC2)OCC4=C3C=CC=C4)C5=C1C=C(Cl)C=C5",{"v":3.58,"d":"3.580"},2,0,4]
["S0518","NS 1738","b10","L4700-09","in 10mM DMSO","AChR","GPCR & G Protein","NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), with respect to positive modulation of Xenopus laevis oocyte α7 nAChR with EC50 of 3.4 μM, as well as a comparable efficacy at the rat α7 nAChR with EC50 of 3.9 μM.",365.13,"501684-93-1",{"v":73,"d":"73.00"},199.93,"<1",null,"http://www.selleckchem.com/products/ns-1738.html","C14H9Cl2F3N2O2","free base","NSC 213859","OC1=CC=C(Cl)C=C1NC(=O)NC2=CC(=CC=C2Cl)C(F)(F)F",4.552,1,3,3]
["S0896","DSP-4 HCl","c10","L4700-09","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, which exclusively affects the noradrenergic fibers from the LC (locus coeruleus).",313.06,"40616-75-9",{"v":83,"d":"83.00"},200.91,{"v":83,"d":"83.00"},200.91,"http://www.selleckchem.com/products/dsp-4-hcl.html","C11H15BrClN.ClH","hydrochloride","Neurotoxin DSP 4 (hydrochloride)","Cl.CCN(CCCl)CC1=C(Br)C=CC=C1",4.048,0,0,5]
["S2948","HG-10-102-01","d10","L4700-09","in 10mM DMSO","LRRK2","Autophagy","HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 with IC50 of 23.3 nM and the G2019S mutant with IC50 of 3.2 nM.",377.83,"1351758-81-0",{"v":76,"d":"76.00"},201.15,"<1",null,"http://www.selleckchem.com/products/hg-10-102-01.html","C17H20ClN5O3","free base","N/A","CNC1=NC(=NC=C1Cl)NC2=C(OC)C=C(C=C2)C(=O)N3CCOCC3",2.219,5,2,5]
["S7274","HLY78","e10","L4700-09","in 10mM DMSO","Apoptosis related","Apoptosis","HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway.",267.32,"854847-61-3",{"v":53,"d":"53.00"},198.26,"<1",null,"http://www.selleckchem.com/products/hly78.html","C17H17NO2","free base",null,"CCC1=C2N(C)CC3=CC4=C(OCO4)C=C3C2=CC=C1",3.974,2,0,1]
["E0454","ARN-19702","f10","L4700-09","in 10mM DMSO","Others","Metabolism","ARN19702 is an orally active, reversible N-Acylethanolamine acid amidase(NAAA) inhibitor (IC50 on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice.",447.55,"1971937-18-4",{"v":89,"d":"89.00"},198.86,"<1",null,"http://www.selleckchem.com/products/arn-19702.html","C21H22FN3O3S2","free base",null,"CC[S](=O)(=O)C1=CC=CC=C1C(=O)N2CCN(CC2C)C3=NC4=CC=C(F)C=C4S3",3.956,4,0,4]
["E0458","RTICBM-189","g10","L4700-09","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay.",309.19,"551909-15-0",{"v":62,"d":"62.00"},200.52,"<1",null,"http://www.selleckchem.com/products/rticbm-189.html","C15H14Cl2N2O","free base","N/A","ClC1=CC=C(NC(=O)NCCC2=CC(=CC=C2)Cl)C=C1",4.179,1,2,4]
["E0646","Ibiglustat succinate","h10","L4700-09","in 10mM DMSO","Glucosylceramide Synthase","Metabolism","Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.",523.58,"1629063-78-0",{"v":100,"d":"100.00"},190.99,{"v":100,"d":"100.00"},190.99,"http://www.selleckchem.com/products/ibiglustat-succinate.html","C20H24FN3O2S.C4H6O5","succinate","Venglustat succinate","CC(C)(NC(=O)OC1CN2CCC1CC2)C3=CSC(=N3)C4=CC=C(F)C=C4.OC(CC(O)=O)C(O)=O",0.421,5,2,8]
["E0998","PFE-360","a11","L4700-09","in 10mM DMSO","LRRK2","Autophagy","PFE-360(PF-06685360) is a brain-penetrant and selective LRRK2 small-molecule kinase inhibitors.",308.34,"1527475-61-1",{"v":31,"d":"31.00"},100.54,"<1",null,"http://www.selleckchem.com/products/pfe-360.html","C16H16N6O","free base","PF-06685360","C[N]1C=C(C=C1C#N)C2=C[NH]C3=NC=NC(=C23)N4CCOCC4",1.921,3,1,2]
["E1265","Deschloroclozapine","b11","L4700-09","in 10mM DMSO","AChR","Neuronal Signaling","Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.",292.38,"1977-07-7",{"v":58,"d":"58.00"},198.37,"<1",null,"http://www.selleckchem.com/products/deschloroclozapine.html","C18H20N4","free base",null,"CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=CC=CC=C24",2.758,1,1,1]
["E2378","GNE-3511","c11","L4700-09","in 10mM DMSO","Mixed Lineage Kinase","MAPK","GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of <0.5 nM.",440.49,"1496581-76-0",{"v":44,"d":"44.00"},99.89,"<1",null,"http://www.selleckchem.com/products/gne-3511.html","C23H26F2N6O","free base",null,"FC1(F)CCN(C1)C2=CC(=CC(=N2)NC3=NC=CC(=C3)C#N)C4CCN(CC4)C5COC5",{"v":3.71,"d":"3.710"},3,1,5]
["P1008","Carbetocin Acetate","d11","L4700-09","in 10mM DMSO","Oxytocin receptor","Endocrinology & Hormones","Carbetocin Acetate is a long-acting oxytocin-analogue and a potent agonist of the oxytocin receptor (OXTR), with improved in vivo stability over oxytocin.",988.16,"37025-55-1",{"v":100,"d":"100.00"},{"v":101.2,"d":"101.20"},{"v":100,"d":"100.00"},{"v":101.2,"d":"101.20"},"http://www.selleckchem.com/peptide/carbetocin-acetate.html","C45H69N11O12S","Acetate",null,"CCC(C)C1NC(=O)C(CC2=CC=C(OC)C=C2)NC(=O)CCCSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(N)=O.CC(O)=O",-1.699,13,10,18]
["S3494","Vicriviroc maleate","e11","L4700-09","in 10mM DMSO","CCR,HIV Protease","GPCR & G Protein","Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.",{"v":649.7,"d":"649.70"},"599179-03-0",{"v":100,"d":"100.00"},153.92,{"v":50,"d":"50.00"},76.96,"http://www.selleckchem.com/products/vicriviroc-maleate.html","C32H42F3N5O6","Maleate","SCH-417690 maleate, SCH-D maleate","COCC(N1CCN(CC1C)C2(C)CCN(CC2)C(=O)C3=C(C)N=CN=C3C)C4=CC=C(C=C4)C(F)(F)F.OC(=O)\\C=C/C(O)=O",-2.926,6,0,9]
["S6767","GSK805","f11","L4700-09","in 10mM DMSO","Others","Others","GSK805 (JNJ 56914845, GSK-2336805) is a potent and orally bioavailable RORγt inhibitor.",532.36,"1426802-50-7",{"v":100,"d":"100.00"},187.84,"<1",null,"http://www.selleckchem.com/products/gsk805.html","C23H18Cl2 F3NO4S","Free base","JNJ 56914845, GSK-2336805","CC[S](=O)(=O)C1=CC=C(CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl)C=C1",7.491,4,1,8]
["S7455","Resatorvid (TAK-242)","g11","L4700-09","in 10mM DMSO","Autophagy,Interleukins,MyD88,TLR,TNF-alpha,TRIF","Immunology & Inflammation","Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.",361.82,"243984-11-4",{"v":72,"d":"72.00"},198.99,"<1",null,"http://www.selleckchem.com/products/resatorvid.html","C15H17ClFNO4S","Free base","CLI-095","CCOC(=O)C1=CCCCC1[S](=O)(=O)NC2=C(Cl)C=C(F)C=C2",3.324,4,1,6]
["S8524","Edicotinib(JNJ-40346527)","h11","L4700-09","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM.",{"v":461.6,"d":"461.60"},"1142363-52-7",{"v":92,"d":"92.00"},199.31,"<1",null,"http://www.selleckchem.com/products/edicotinib.html","C27H35N5O2","Free base",null,"CC1(C)CCC(=CC1)C2=NC(=CC=C2NC(=O)C3=NC=C([NH]3)C#N)C4CC(C)(C)OC(C)(C)C4",{"v":4.56,"d":"4.560"},4,2,4]
["S8600","Elenbecestat","a2","L4700-10","in 10mM DMSO","BACE","Neuronal Signaling","Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.",437.44,"1388651-30-6",{"v":87,"d":"87.00"},198.88,"<1",null,"http://www.selleckchem.com/products/elenbecestat.html","C19H18F3N5O2S","Free base","E2609","CC1OCC2(N=C(N)SCC12)C3=C(F)C=CC(=C3)NC(=O)C4=CN=C(C=N4)C(F)F",2.037,5,2,4]
["S8890","MK-8719","b2","L4700-10","in 10mM DMSO","OGA","Autophagy","MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA.",268.28,"1382799-40-7",{"v":54,"d":"54.00"},201.28,{"v":54,"d":"54.00"},201.28,"http://www.selleckchem.com/products/mk-8719.html","C9H14F2N2O3S","Free base","N/A","CCNC1=NC2C(O)C(O)C(OC2S1)C(F)F",0.439,2,3,3]
["E0041","Tolebrutinib (SAR442168)","c2","L4700-10","in 10mM DMSO","BTK","Angiogenesis","Tolebrutinib (SAR442168, PRN2246, BTKi'168, BTKi('168)) is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine kinase (BTK) with IC50s of 0.4 nM and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.",455.51,"1971920-73-6",{"v":91,"d":"91.00"},199.78,"<1",null,"http://www.selleckchem.com/products/tolebrutinib-sar442168.html","C₂₆H₂₅N₅O₃","Free base","PRN2246","NC1=NC=CC2=C1N(C(=O)N2C3CCCN(C3)C(=O)C=C)C4=CC=C(OC5=CC=CC=C5)C=C4",3.469,4,1,5]
["E0077","Simufilam","d2","L4700-10","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. Simufilam reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7nAChR.",259.35,"1224591-33-6","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"$nulls":3},"http://www.selleckchem.com/products/simufilam.html","C₁₅H₂₁N₃O","Free base","PTI-125","CN1CCC2(CC1)NCC(=O)N2CC3=CC=CC=C3",1.098,1,1,2]
["E1183","MRTX0902","e2","L4700-10","in 10mM DMSO","Others","Others","MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM.",388.47,"2654743-22-1",{"v":100,"d":"100.00"},257.42,"<1",null,"http://www.selleckchem.com/products/mrtx0902.html","C22H24N6O","Free base",null,"CC(NC1=NN=C(C)C2=C1C=C(N=C2)N3CCOCC3)C4=C(C)C(=CC=C4)C#N",3.315,4,1,4]
["E2819","PF-04802367","f2","L4700-10","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","PF-04802367 (PF-367) is a highly selective Glycogen synthase kinase-3 (GSK-3) inhibitor with IC50s of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.",361.78,"1962178-27-3",{"v":72,"d":"72.00"},199.02,"<1",null,"http://www.selleckchem.com/products/pf-04802367.html","C16H16ClN5O3","Free base","PF-367","COC1=C(Cl)C=C(C=C1)C2=C(N=CO2)C(=O)NCCC[N]3C=NC=N3",1.498,6,1,7]
["E4415","Dimethyl malonate","g2","L4700-10","in 10mM DMSO","Dehydrogenase","Metabolism","Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis.",132.11,"108-59-8",null,">10",null,null,"https://www.selleckchem.com/products/dimethyl-malonate.html","C5H8O4","free base",null,"COC(=O)CC(=O)OC",0.057,4,0,4]
["E0620","LIT-001 trifluoroacetate","h2","L4700-10","in 10mM DMSO","Others","Others","LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism.",{"v":645.7,"d":"645.70"},"2245072-21-1",{"v":100,"d":"100.00"},154.87,"<1",null,"https://www.selleckchem.com/products/lit-001-trifluoroacetate.html","C30H34F3N7O4S","trifluoroacetate","LIT-001 TFA","CN(C)C(=S)C1CCCN1C(=O)NCC2=C(C)C=C(C=C2)C(=O)N3CC4=C(NC5=CC=CC=C35)[N](C)N=C4.OC(=O)C(F)(F)F",4.883,4,2,6]
["E1255","5-Ethynyluridine","a3","L4700-10","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","5-Ethynyluridine (5-EU) is a cell-permeable nucleoside and can be used to label newly synthesized RNA.",268.22,"69075-42-9",{"v":54,"d":"54.00"},201.33,{"v":14,"d":"14.00"},{"v":52.2,"d":"52.20"},"https://www.selleckchem.com/products/5-ethynyluridine.html","C11H12N2O6","free base",null,"OCC1OC(C(O)C1O)N2C=C(C#C)C(=O)NC2=O",-1.364,3,4,2]
["E1312","DPH","b3","L4700-10","in 10mM DMSO","Bcr-Abl","Protein Tyrosine Kinase","DPH is a potent cell permeable c-Abl activator, with an EC50 of 794 nM.",336.32,"484049-04-9",{"v":67,"d":"67.00"},199.22,"<1",null,"https://www.selleckchem.com/products/dph.html","C18H13FN4O2","free base",null,"FC1=CC=C(C=C1)C2=N[N](C=C2C3NC(=O)NC3=O)C4=CC=CC=C4",2.937,3,2,3]
["E2933","MOMIPP","c3","L4700-10","in 10mM DMSO","PIKfyve","PI3K/Akt/mTOR","MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.",292.33,"1363421-46-8",{"v":15,"d":"15.00"},51.31,"<1",null,"https://www.selleckchem.com/products/momipp.html","C18H16N2O2","Free base",null,"COC1=CC=C2[NH]C(=C(\\C=C\\C(=O)C3=CC=NC=C3)C2=C1)C",2.974,3,1,4]
["S0984","KCC-07","d3","L4700-10","in 10mM DMSO","Others","Epigenetics","KCC-07 is a potent, selective and brain-penetrant inhibitor of MBD2 (methyl-CpG-binding domain protein 2) with anticancer activity. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.",269.32,"315702-75-1",{"v":54,"d":"54.00"},{"v":200.5,"d":"200.50"},"<1",null,"https://www.selleckchem.com/products/kcc-07.html","C14H11N3OS","Free base",null,"OC1=CC=CC(=C1)NC2=NC(=CS2)C3=CC=CC=N3",{"v":3.36,"d":"3.360"},2,2,3]
["E1478","BDTX-1535","e3","L4700-10","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","BDTX-1535 (EGFR-IN-76) is an orally available, highly potent, selective, and irreversible EGFR inhibitor that can penetrate the blood-brain barrier, with the potential to treat Glioblastoma or Non-Small Cell Lung Cancer.",561.05,"2607829-38-7",{"v":100,"d":"100.00"},178.24,"<1",null,"https://www.selleckchem.com/products/bdtx-1535.html","C30H30ClFN6O2","Free base","EGFR-IN-76","CN1CC2CC2(C1)C#CC3=CC4=C(C=C3NC(=O)\\C=C\\CN5CCOCC5)C(=NC=N4)NC6=C(F)C(=CC=C6)Cl",{"v":4.5,"d":"4.500"},4,2,8]
["E4042","5,5-Dimethyl-1-pyrroline N-oxide","f3","L4700-10","in 10mM DMSO","Others","Others","5,5-Dimethyl-1-pyrroline N-oxide (DMPO) is a cell-permeable hydrophilic spin trap agent for superoxide detection. It acts as a neuroprotective agent and incubating lymphocytes with DMPO decreases DNA damage by NiCl2.",113.16,"3317-61-1",{"v":23,"d":"23.00"},203.25,{"v":23,"d":"23.00"},203.25,"https://www.selleckchem.com/products/5,5-dimethyl-1-pyrroline-n-oxide.html","C6H11NO","Free base","DMPO","CC1(C)CCC=[N]1=O",0.757,0,0,0]
["S2966","TTK21","g3","L4700-10","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","TTK21 is an activator of the histone acetyltransferases CBP/p300. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 µM. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different brain parts when conjugated to glucose-based carbon nanosphere (CSP).",357.76,"709676-56-2",{"v":72,"d":"72.00"},201.25,"<1",null,"https://www.selleckchem.com/products/ttk21.html","C17H15ClF3NO2","Free base",null,"CCCOC1=C(C=CC=C1)C(=O)NC2=CC(=C(Cl)C=C2)C(F)(F)F",5.077,2,1,6]
["S6952","MK-28","h3","L4700-10","in 10mM DMSO","PERK","Apoptosis","MK-28 is a potent and selective activator of PERK. MK-28 exhibits an IC50 ~3-fold higher than CCT020312 in rescuing mutant huntingtin protein (mHtt)-expressing striatal neurons from apoptosis. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice.",396.44,"864388-65-8",{"v":79,"d":"79.00"},199.27,"<1",null,"https://www.selleckchem.com/products/mk-28.html","C24H20N4O2","Free base",null,"CN(\\N=C\\C1=CC(=C(O)C=C1)O)C2=NC(=CC(=N2)C3=CC=CC=C3)C4=CC=CC=C4",5.806,3,2,5]
["E1028","POMHEX","a4","L4700-10","in 10mM DMSO","Others","Metabolism","POMHEX,  is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.",{"v":423.4,"d":"423.40"},"2004714-34-3",{"v":85,"d":"85.00"},200.76,{"v":5,"d":"5.00"},11.81,"https://www.selleckchem.com/products/pomhex.html","C17H30NO9P","Free base",null,"CC(C)(C)C(=O)OCO[P](=O)(OCOC(=O)C(C)(C)C)C1CCCN(O)C1=O",{"v":1.9,"d":"1.900"},7,0,11]
["E1409","Zidesamtinib","b4","L4700-10","in 10mM DMSO","ROS1","Protein Tyrosine Kinase","Zidesamtinib (NVL-520) is a potent brain-penetrating inhibitor of ROS1 tyrosine kinase with IC50 of 0.7 nM for wild-type ROS1 . It acts as a potential antineoplastic agent and can be used for the research of cancer.",419.46,"2739829-00-4",{"v":84,"d":"84.00"},200.26,"<1",null,"https://www.selleckchem.com/products/zidesamtinib.html","C22H22FN7O","Free base","NVL-520, NVL520","CC[N]1N=CC2=C1C3=CC(=C(N)N=C3)OC(C)C4=CC(=CC=C4C5=N[N](C)N=C5C2)F",3.529,5,1,1]
["E4016","Phenylarsine oxide","c4","L4700-10","in 10mM DMSO","phosphatase","Metabolism","Phenylarsine oxide (Oxophenylarsine) is a membrane-permeable protein tyrosine phosphatase inhibitor with IC50 18 µM. It Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle.",168.03,"637-03-6",{"v":25,"d":"25.00"},148.78,"<1",null,"https://www.selleckchem.com/products/phenylarsine-oxide.html","C6H5AsO","Free base","Oxophenylarsine","O=[As]C1=CC=CC=C1",1.655,0,0,1]
["P1079","Bax inhibitor peptide V5","d4","L4700-10","in 10mM DMSO","Bcl-2","Apoptosis","Bax inhibitor peptide V5 (BIP-V5 , BAX Inhibiting Peptide V5) is a cell-permeable pentapeptide that blocks the ku70 binding domain and prevents Bax conformational change and mitochondrial translocation. It Inhibits Bax-mediated apoptosis.",586.79,"579492-81-2",{"v":100,"d":"100.00"},170.42,{"v":100,"d":"100.00"},170.42,"https://www.selleckchem.com/products/Bax-inhibitor-peptide-V5.html","C27H50N6O6S","Free base"]
["S1116","Palbociclib (PD-0332991) HCl","a2","L4700-11","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",483.99,"827022-32-2",{"v":3,"d":"3.00"},{"v":6.2,"d":"6.20"},{"v":30,"d":"30.00"},61.98,"http://selleckchem.com/products/PD-0332991.html","C24H29N7O2.HCl","Hydrochloride","N/A","Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O",3.183,5,2,5]
["S1135","Pemetrexed (LY-231514) disodium","b2","L4700-11","in 10mM Water","Apoptosis related,Autophagy,DHFR,DNA/RNA Synthesis,Thymidylate Synthase","Metabolism","Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.",471.37,"150399-23-8","<1",null,{"v":94,"d":"94.00"},199.42,"http://selleckchem.com/products/Pemetrexed-disodium.html","C20H19N5Na2O6","Disodium salt","LY-231514 disodium","[Na+].[Na+].NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N1",-1.804,3,4,9]
["S1339","Galanthamine HBr","c2","L4700-11","in 10mM Water","AChR,ADC Cytotoxin","Neuronal Signaling","Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.",368.27,"1953-04-4","<1",null,{"v":36,"d":"36.00"},97.75,"http://selleckchem.com/products/Galanthamine-hydrobromide.html","C17H21NO3.HBr","Hydrobromide","N/A","Br.COC1=CC=C2CN(C)CCC34C=CC(O)CC3OC1=C24",1.933,2,1,1]
["S1345","Granisetron HCl","d2","L4700-11","in 10mM Water","5-HT Receptor","Neuronal Signaling","Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.",348.87,"107007-99-8",{"v":1,"d":"1.00"},2.87,{"v":69,"d":"69.00"},197.78,"http://selleckchem.com/products/Granisetron-Hydrochloride.html","C18H24N4O.HCl","Hydrochloride","N/A","Cl.CN1C2CCCC1CC(C2)NC(=O)C3=N[N](C)C4=CC=CC=C34",2.783,2,1,2]
["S1440","Varenicline Tartrate (CP 526555-18)","e2","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Varenicline Tartrate (CP 526555-18, Chantix, Champix) is a nicotinic AChR partial agonist, used to treat nicotine addiction.",361.35,"375815-87-5",{"v":1,"d":"1.00"},2.77,{"v":72,"d":"72.00"},199.25,"http://selleckchem.com/products/Varenicline-tartrate.html","C13H13N3.C4H6O6","Tartrate","Chantix, Champix,CP 526555-18","OC(C(O)C(O)=O)C(O)=O.C1NCC2CC1C3=C2C=C4N=CC=NC4=C3",{"v":-3.33,"d":"-3.330"},4,3,3]
["S1518","Ibuprofen Lysine","f2","L4700-11","in 10mM Water","COX","Neuronal Signaling","Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.",352.47,"57469-77-9","<1",null,{"v":71,"d":"71.00"},201.44,"http://selleckchem.com/products/Ibuprofen-Lysine(Motrin).html","C19H32N2O4","Lysine","N/A","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O.NCCCCC(N)C(O)=O",-2.112,2,2,9]
["S1579","Palbociclib (PD0332991) Isethionate","g2","L4700-11","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",573.66,"827022-33-3","<1",null,{"v":10,"d":"10.00"},17.43,"http://selleckchem.com/products/pd-0332991-palbociclib-isethionate.html","C24H29N7O2.C2H6O4S","Isethionate","N/A","CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O.OCC[S](O)(=O)=O",1.847,5,3,7]
["S1648","Cytarabine (U-19920A)","h2","L4700-11","in 10mM Water","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459,U-19920A) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.",243.22,"147-94-4",{"v":1,"d":"1.00"},4.11,{"v":48,"d":"48.00"},197.35,"http://selleckchem.com/products/Cytarabine(Cytosar-U).html","C9H13N3O5","free base","Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459,U-19920A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S1853","Penicillamine","a3","L4700-11","in 10mM Water","Others","Others","Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease.",149.21,"52-67-5","<1",null,{"v":30,"d":"30.00"},201.06,"http://selleckchem.com/products/Penicillamine(Cuprimine).html","C5H11NO2S","free base","Dimethyl Cysteine","CC(C)(S)C(N)C(O)=O",-2.496,1,1,2]
["S1875","Tranexamic Acid","b3","L4700-11","in 10mM Water","Others","Others","Tranexamic Acid(Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.",157.21,"1197-18-8","<1",null,{"v":31,"d":"31.00"},197.19,"http://selleckchem.com/products/tranexamic-acid-transamin.html","C8H15NO2","free base","Transamin","NCC1CCC(CC1)C(O)=O",-1.753,1,1,2]
["S1995","Procarbazine HCl","c3","L4700-11","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.",257.76,"366-70-1","<1",null,{"v":52,"d":"52.00"},201.74,"http://selleckchem.com/products/procarbazine-hydrochloride-matulane.html","C12H19N3O.HCl","Hydrochloride","NSC-77213 HCl","Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C",{"v":1.12,"d":"1.120"},1,3,5]
["S1998","D-Cycloserine","d3","L4700-11","in 10mM Water","Antibiotics,Selection Antibiotics for Transfected Cell","Microbiology","D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.",102.09,"68-41-7","<1",null,{"v":20,"d":"20.00"},195.91,"http://selleckchem.com/products/D-Cycloserine.html","C3H6N2O2","free base","RO-1-9213","NC1CONC1=O",-1.788,2,2,0]
["S2133","Gabapentin","e3","L4700-11","in 10mM Water","GABA Receptor","Neuronal Signaling","Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.",171.24,"60142-96-3","<1",null,{"v":34,"d":"34.00"},198.55,"http://selleckchem.com/products/Gabapentin(Neurontin).html","C9H17NO2","Free Base","N/A","NCC1(CCCCC1)CC(O)=O",-1.486,1,1,3]
["S2462","Donepezil HCl","f3","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.",{"v":416,"d":"416.00"},"120011-70-3","<1",null,{"v":5,"d":"5.00"},12.02,"http://selleckchem.com/products/Donepezil-hydrochloride(Aricept).html","C24H29NO3.HCl","Hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)CC2=C1",4.951,3,0,6]
["S2490","Neostigmine Bromide","g3","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.",{"v":303.2,"d":"303.20"},"114-80-7","<1",null,{"v":60,"d":"60.00"},197.89,"http://selleckchem.com/products/Neostigmine-bromide(Prostigmin).html","C12H19N2O2.Br","Bromide","N/A","[Br-].CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C",-1.907,2,0,3]
["S2572","Streptomycin sulfate","h3","L4700-11","in 10mM Water","Antibiotics for Plant Cell Culture,Anti-infection,Selection Antibiotics for Transfected Cell","Microbiology","Streptomycin sulfate(Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.",1457.38,"3810-74-0","<1",null,{"v":89,"d":"89.00"},61.07,"http://selleckchem.com/products/streptomycin-sulfate.html","2C21H39N7O12.3H2SO4","1.5 Sulfate","Phytomycin","CNC1C(O)C(O)C(CO)OC1OC2C(OC(C)C2(O)C=O)OC3C(O)C(O)C(NC(N)=N)C(O)C3NC(N)=N.CNC4C(O)C(O)C(CO)OC4OC5C(OC(C)C5(O)C=O)OC6C(O)C(O)C(NC(N)=N)C(O)C6NC(N)=N.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-14.403,10,22,22]
["S3048","Solifenacin succinate","a4","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.",480.55,"242478-38-2",{"v":3,"d":"3.00"},6.24,{"v":96,"d":"96.00"},199.77,"http://selleckchem.com/products/solifenacin-succinate.html","C23H26N2O.C4H6O4","Succinate","YM905","OC(=O)CCC(O)=O.O=C(OC1CN2CCC1CC2)N3CCC4=C(C=CC=C4)C3C5=CC=CC=C5",0.635,4,0,6]
["S3050","Palonosetron HCl","b4","L4700-11","in 10mM Water","5-HT Receptor","Neuronal Signaling","Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.",332.87,"135729-62-3","<1",null,{"v":67,"d":"67.00"},201.28,"http://selleckchem.com/products/palonosetron-hcl.html","C19H24N2O.HCl","HCL","RS 25259, RS 25259 197","Cl.O=C1N(CC2CCCC3=CC=CC1=C23)C4CN5CCC4CC5",3.127,1,0,1]
["S3165","Abacavir sulfate","c4","L4700-11","in 10mM Water","Reverse Transcriptase","Microbiology","Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.",335.35,"188062-50-2","<1",null,{"v":36,"d":"36.00"},107.35,"http://selleckchem.com/products/abacavir-sulfate.html","C14H18N6O.1/2H2SO4","Sulfate","1592U89","NC1=NC2=C(N=C[N]2C3CC(CO)C=C3)C(=N1)NC4CC4.NC5=NC6=C(N=C[N]6C7CC(CO)C=C7)C(=N5)NC8CC8.O[S](O)(=O)=O",0.932,6,6,8]
["S3649","Ceftazidime","d4","L4700-11","in 10mM Water","Anti-infection,Selection Antibiotics for Transfected Cell","Microbiology","Ceftazidime(GR20263) is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.",546.58,"72558-82-8",{"v":4,"d":"4.00"},7.32,{"v":100,"d":"100.00"},182.96,"http://selleckchem.com/products/ceftazidime.html","C22H22N6O7S2","inner salt","GR20263","CC(C)(O\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3=CC=CC=C3)C4=CSC(=N4)N)C(O)=O",-0.693,6,2,9]
["S3662","Pirenzepine dihydrochloride","e4","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.",424.32,"29868-97-1",{"v":1,"d":"1.00"},2.36,{"v":84,"d":"84.00"},197.96,"http://selleckchem.com/products/pirenzepine-dihydrochloride.html","C19H21N5O2.2HCl","dihydrochloride","N/A","Cl.Cl.CN1CCN(CC1)CC(=O)N2C3=C(C=CC=C3)C(=O)NC4=CC=CN=C24",1.803,3,1,2]
["S3748","Acamprosate Calcium","f4","L4700-11","in 10mM Water","GABA Receptor","Transmembrane Transporters","Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.",200.24,"77337-73-6","<1",null,{"v":40,"d":"40.00"},199.76,"http://selleckchem.com/products/acamprosate-calcium.html","C5H11NO4S.1/2Ca","calcium salt","N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate,N-acetylhomotaurinate","CC(=O)NCCC[S]([O-])(=O)=O",{"v":-2.67,"d":"-2.670"},1,1,4]
["S3852","L-Theanine","g4","L4700-11","in 10mM Water","Others","Others","L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation.",{"v":174.2,"d":"174.20"},"3081-61-6","<1",null,{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-theanine.html","C7H14N2O3","free base","N/A","CCNC(=O)CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4027","Flavoxate HCl","h4","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Flavoxate (NSC-114649) is a muscarinic AChR antagonist with IC50 of 12.2 μM.",427.92,"3717-88-2",{"v":3,"d":"3.00"},7.01,{"v":10,"d":"10.00"},23.37,"http://selleckchem.com/products/flavoxate-hcl.html","C24H25NO4.HCl","hydrochloride","NSC-114649","Cl.CC1=C(OC2=C(C=CC=C2C(=O)OCCN3CCCCC3)C1=O)C4=CC=CC=C4",4.876,4,0,6]
["S4028","Dexamethasone Sodium Phosphate","a5","L4700-11","in 10mM Water","Autophagy,Complement System,COVID-19,COX,IL Receptor","Immunology & Inflammation","Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":516.4,"d":"516.40"},"55203-24-2","<1",null,{"v":103,"d":"103.00"},199.46,"http://selleckchem.com/products/dexamethasone-sodium-phosphate.html","C22H30FO8P.2Na","Disodium salt","Dexamethasone 21-phosphate disodium salt","[Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O",-0.541,3,1,4]
["S4069","Hexamethonium Dibromide","b5","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.",362.19,"55-97-0","<1",null,{"v":73,"d":"73.00"},201.55,"http://selleckchem.com/products/hexamethonium-bromide.html","C12H30N2.2Br","Bromide","N/A","[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C",-5.532,0,0,7]
["S4121","Succinylcholine Chloride Dihydrate","c5","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Succinylcholine Chloride Dihydrate (Suxamethonium) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.",397.34,"6101-15-1",{"v":1,"d":"1.00"},2.52,{"v":79,"d":"79.00"},198.82,"http://selleckchem.com/products/succinylcholine-suxamethonium-chloride-dihydrate.html","C14H30N2O4.2Cl.2H2O","Chloride","Suxamethonium Chloride Dihydrate","O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C",-8.102,4,0,11]
["S4360","Tolmetin Sodium","d5","L4700-11","in 10mM Water","COX","Immunology & Inflammation","Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.",{"v":315.3,"d":"315.30"},"64490-92-2","<1",{"v":0,"d":"0.00"},{"v":63,"d":"63.00"},199.81,"http://www.selleckchem.com/products/tolmetin-sodium.html","C15H14NO3.Na.2H2O","sodium","MCN2559","O.O.C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(=O)O[Na]",2.943,3,0,5]
["S4575","Pralidoxime chloride","e5","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Pralidoxime chloride (2-PAM) is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.",172.61,"51-15-0","<1",null,{"v":34,"d":"34.00"},196.98,"http://selleckchem.com/products/pralidoxime-chloride.html","C7H9N2O.Cl","chloride","2-PAM (chloride)","[Cl-].C[N+]1=C(C=CC=C1)\\C=N\\O",-1.122,1,0,1]
["S4700","4-Aminobutyric acid (GABA)","f5","L4700-11","in 10mM Water","GABA Receptor","Neuronal Signaling","4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.",103.12,"56-12-2","<1",null,{"v":20,"d":"20.00"},193.95,"http://selleckchem.com/products/4-aminobutyric-acid.html","C4H9NO2","free base","4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid","NCCCC(O)=O",-3.076,1,1,3]
["S4703","Choline bitartrate","g5","L4700-11","in 10mM Water","AChR","Neuronal Signaling","Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.",253.25,"87-67-2","<1",null,{"v":50,"d":"50.00"},197.43,"http://selleckchem.com/products/choline-bitartrate.html","C5H14NO.C4H5O6","tartrate","2-hydroxyethyl(trimethyl)azanium;2,3,4-trihydroxy-4-oxobutanoate","C[N+](C)(C)CCO.OC(C(O)C([O-])=O)C(O)=O",-4.712,1,3,5]
["S4740","Sodium ferulate","h5","L4700-11","in 10mM Water","5-HT Receptor","Neuronal Signaling","Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.",216.17,"24276-84-4",{"v":2,"d":"2.00"},9.25,{"v":43,"d":"43.00"},198.92,"http://selleckchem.com/products/ferulic-acid-sodium.html","C10H9O4.Na","Sodium salt","Ferulic acid sodium salt","[Na+].COC1=CC(=CC=C1O)\\C=C\\C([O-])=O",0.195,1,1,3]
["S4972","Choline Glycerophosphate","a6","L4700-11","in 10mM Water","Others","Others","Choline Glycerophosphate (Glycerophosphorylcholine) is a choline derivative and one of the two major forms of choline storage (along with phosphocholine) in the cytosol.",257.22,"28319-77-9",{"v":2,"d":"2.00"},7.78,{"v":51,"d":"51.00"},198.27,"http://selleckchem.com/products/choline-glycerophosphate.html","C8H20NO6P",null,"Glycerophosphorylcholine","C[N+](C)(C)CCO[P]([O-])(=O)OCC(O)CO",-4.131,2,2,8]
["S5048","Fosfomycin Disodium","b6","L4700-11","in 10mM Water","Antibiotics,Bacterial","Microbiology","Fosfomycin (Phosphonemycin) is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.",182.02,"26016-99-9","<1",null,{"v":36,"d":"36.00"},197.78,"http://selleckchem.com/products/fosfomycin-disodium.html","C3H5O4P.2Na","sodium","Phosphonemycin Disodium","[Na+].[Na+].CC1OC1[P]([O-])([O-])=O",-2.496,1,0,1]
["S5097","Methotrexate disodium","c6","L4700-11","in 10mM Water","Dehydrogenase,DHFR","Metabolism","Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.",{"v":498.4,"d":"498.40"},"7413-34-5","<1",null,{"v":99,"d":"99.00"},198.64,"http://selleckchem.com/products/methotrexate-disodium.html","C20H20N8O5.2Na","disodium salt","N/A","[Na+].[Na+].CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O",-2.834,5,3,9]
["S5131","Homotaurine","d6","L4700-11","in 10mM Water","GABA Receptor","Neuronal Signaling","Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.",139.17,"3687-18-1",null,null,{"v":27,"d":"27.00"},194.01,"http://selleckchem.com/products/homotaurine.html","C3H9NO3S","free base","Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid","NCCC[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S5631","L-Alanine","e6","L4700-11","in 10mM Water","Others","Others","Alanine is a naturally occuring non-essential amino acid that is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brainR, and the CNS.",89.09,"56-41-7","<1",null,{"v":17,"d":"17.00"},190.82,"http://selleckchem.com/products/l-alanine.html","C3H7NO2","free base","N/A","CC(N)C(O)=O",-3.161,1,1,1]
["S5632","L-aspartic Acid","f6","L4700-11","in 10mM Water","Others","Others","L-aspartic Acid is one of non-essential amino acids and may be a neurotransmitter.",{"v":133.1,"d":"133.10"},"56-84-8","<1",null,{"v":8,"d":"8.00"},60.11,"http://selleckchem.com/products/l-aspartic-acid.html","C4H7NO4","free base","N/A","NC(CC(O)=O)C(O)=O",{"v":-3.78,"d":"-3.780"},2,1,3]
["S6141","Anserine","g6","L4700-11","in 10mM Water","Others","Others","Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency.",240.26,"584-85-0",null,null,{"v":48,"d":"48.00"},199.83,"http://www.selleck.cn/products/anserine.html","C10H16N4O3","free base","β-alanyl-N-methylhistidine","C[N]1C=NC=C1CC(NC(=O)CCN)C(O)=O",-4.199,3,2,6]
["S7785","Pemetrexed Disodium Hydrate","h6","L4700-11","in 10mM Water","Apoptosis related,Autophagy,DHFR","Metabolism","Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.",516.42,"357166-30-4","<1",null,{"v":100,"d":"100.00"},193.64,"http://selleckchem.com/products/pemetrexed-disodium-hydrate.html","C20H21N5O6.5/2H2O.2Na","Disodium Hydrate","LY-231514 Disodium Hydrate","NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O[Na])C(=O)O[Na])N1",{"v":2.06,"d":"2.060"},7,4,11]
["S7809","MCC950 Sodium (CP-456773 Sodium)","a7","L4700-11","in 10mM Water","NLRP3","Immunology & Inflammation","MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.",426.46,"256373-96-3","<1",null,{"v":85,"d":"85.00"},199.32,"http://selleckchem.com/products/mcc950-sodium-salt.html","C20H23N2O5S.Na","Sodium","CRID3 sodium salt","CC(C)(O)C1=COC(=C1)[S](=O)(=O)N([Na])C(=O)NC2=C3CCCC3=CC4=C2CCC4",3.521,4,1,4]
["S5956","Dexamethasone phosphate disodium","b7","L4700-11","in 10mM Water","Glucocorticoid Receptor","Endocrinology & Hormones","Dexamethasone phosphate disodium (DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex) is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects.",{"v":516.4,"d":"516.40"},"2392-39-4","<1",null,{"v":100,"d":"100.00"},193.65,"http://www.selleckchem.com/products/dexamethasone-phosphate-disodium.html","C22H28FNa2O8P","Disodium","DEX, Dexacort, Decadron, Dexair, Hexadrol, Maxidex, Dexamethasone 21-phosphate disodium salt","[Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O",-0.541,3,1,4]
["S6482","Fosphenytoin (disodium)","c7","L4700-11","in 10mM Water","Others","Others","Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration.",406.24,"92134-98-0",{"$nulls":3},{"v":10,"d":"10.00"},"http://www.selleck.cn/products/fosphenytoin.html","C16H13N2Na2O6P","disodium","N/A","[Na+].[Na+].[O-][P]([O-])(=O)OCN1C(=O)NC(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3",-0.495,3,1,5]
["E4108","L-Aspartic aicd (sodium)","d7","L4700-11","in 10mM Water","Others","Metabolism","L-Aspartic aicd (sodium) is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.",155.08,"3792-50-5",{"$nulls":3},">10","https://www.selleckchem.com/products/l-aspartic-aicd-sodium.html","C4H6NNaO4","sodium","Sodium L-aspartate","[Na;v0].NC(CC(O)=O)C(O)=O",{"v":-3.78,"d":"-3.780"},2,1,3]
["S1023","Erlotinib (OSI-774) HCl","a2","L4700-12","in 2mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781) HCl is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.",{"v":429.9,"d":"429.90"},"183319-69-9",{"v":4,"d":"4.00"},{"v":9.3,"d":"9.30"},"<1",null,"http://selleckchem.com/products/Erlotinib-Hydrochloride.html","C22H23N3O4.HCl","Hydrochloride","CP358774, NSC 718781,OSI-774 HCl","Cl.COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.691,6,1,10]
["S1043","Tandutinib (MLN518)","b2","L4700-12","in 2mM DMSO","FLT3","Angiogenesis","Tandutinib (MLN518, CT53518, NSC726292) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.",{"v":562.7,"d":"562.70"},"387867-13-2",{"v":5,"d":"5.00"},8.89,"<1",null,"http://selleckchem.com/products/Tandutinib-(MLN518).html","C31H42N6O4","Free Base","CT 53518, NSC726292, MLN518","COC1=CC2=C(C=C1OCCCN3CCCCC3)N=CN=C2N4CCN(CC4)C(=O)NC5=CC=C(OC(C)C)C=C5",4.674,6,1,10]
["S1046","Vandetanib (ZD6474)","c2","L4700-12","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1",null,"http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1371","Cefoselis Sulfate","d2","L4700-12","in 2mM DMSO","Antibiotics","Microbiology","Cefoselis (FK 037 Sulfate) is a widely used beta-lactam antibiotic.",620.64,"122841-12-7",{"v":3,"d":"3.00"},4.83,{"v":5,"d":"5.00"},8.06,"http://selleckchem.com/products/Cefoselis-sulfate.html","C19H22N8O6S2.H2SO4","Sulfate","FK 037 Sulfate","CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)CN3C=CC(=N)N3CCO)C4=CSC(=N4)N.O[S](O)(=O)=O",-2.894,6,3,9]
["S1463","Ofloxacin","e2","L4700-12","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ofloxacin (DL8280) is a synthetic broad-spectrum antimicrobial agent.",361.37,"82419-36-1",{"v":1,"d":"1.00"},2.77,"<1",null,"http://www.selleck.cn/products/Ofloxacin(Floxin).html","C18H20FN3O4","Free Base","DL8280","CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F",-1.374,3,0,2]
["S1615","Risperidone","f2","L4700-12","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Risperidone (R-64766) is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.",410.48,"106266-06-2",{"v":4,"d":"4.00"},9.74,"<1",null,"http://selleckchem.com/products/Risperidone(Risperdal).html","C23H27FN4O2","free base","R-64766","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCCC5=N1",3.317,4,0,4]
["S1642","Methyldopa","g2","L4700-12","in 2mM DMSO","5-HT Receptor,Adrenergic Receptor,Decarboxylase,Dopamine Receptor","Metabolism","Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.",211.21,"555-30-6",{"v":2,"d":"2.00"},9.47,"<1",null,"http://selleckchem.com/products/Methyldopa(Aldomet).html","C10H13NO4","free base","N/A","CC(N)(CC1=CC(=C(O)C=C1)O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S1724","Paliperidone","h2","L4700-12","in 2mM DMSO","Dopamine Receptor","Neuronal Signaling","Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.",426.48,"144598-75-4",{"v":4,"d":"4.00"},9.38,"<1",null,"http://selleckchem.com/products/Paliperidone(Invega).html","C23H27FN4O3","free base","N/A","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCC(O)C5=N1",{"v":0,"d":"0.000"},0,0,0]
["S1929","Irsogladine","a3","L4700-12","in 2mM DMSO","AChR,PDE","Metabolism","Irsogladine(Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.",256.09,"57381-26-7",{"v":2,"d":"2.00"},7.81,"<1",null,"http://selleckchem.com/products/Irsogladine-maleate.html","C9H7Cl2N5","free base","Dicloguamine","NC1=NC(=NC(=N1)C2=C(Cl)C=CC(=C2)Cl)N",2.443,3,2,1]
["S2047","Lornoxicam","b3","L4700-12","in 2mM DMSO","COX","Neuronal Signaling","Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.",371.82,"70374-39-9",{"v":3,"d":"3.00"},8.07,"<1",null,"http://selleckchem.com/products/lornoxicam-xefo.html","C13H10ClN3O4S2","free base","Chlortenoxicam","CN1C(=C(O)C2=C(C=C(Cl)S2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.913,4,2,2]
["S2110","Vinpocetine","c3","L4700-12","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","Vinpocetine (RGH-4405,Ethyl apovincaminate,AY 27255) is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia  and Alzheimer's disease.",350.45,"42971-09-5",{"v":3,"d":"3.00"},8.56,"<1",null,"http://selleckchem.com/products/vinpocetine-cavinton.html","C22H26N2O2","free base","RGH-4405,Ethyl apovincaminate,AY 27255","CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)[N]1C5=CC=CC=C45",{"v":0,"d":"0.000"},0,0,0]
["S2232","Ketanserin","d3","L4700-12","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Ketanserin (R41468, Ketanserinum) is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.",395.43,"74050-98-9",{"v":2,"d":"2.00"},5.06,"<1",null,"http://selleckchem.com/products/Ketanserin-Vulketan-Gel.html","C22H22FN3O3","Free Base","R41468, Ketanserinum","FC1=CC=C(C=C1)C(=O)C2CCN(CC2)CCN3C(=O)NC4=CC=CC=C4C3=O",2.991,3,1,5]
["S2251","(-)-Huperzine A (HupA)","e3","L4700-12","in 2mM DMSO","AChR,GluR","Neuronal Signaling","(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.",242.32,"102518-79-6",0.66,2.72,"<1",null,"http://selleckchem.com/products/(-)-Huperzine-A.html","C15H18N2O","Free Base","N/A","C\\C=C/1C2CC3=C(C=CC(=O)N3)C1(N)CC(=C2)C",1.056,1,2,0]
["S2476","Itraconazole (R 51211)","f3","L4700-12","in 2mM DMSO","Autophagy,Fungal,Hedgehog/Smoothened,P450 (e.g. CYP17)","Stem Cells & Wnt","Itraconazole (R 51211) is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.",705.65,"84625-61-6",{"v":7,"d":"7.00"},9.92,"<1",null,"http://selleckchem.com/products/Itraconazole(Sporanox).html","C35H38Cl2N8O4","free base","R 51211","CCC(C)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C[N]6C=NC=N6)(O5)C7=CC=C(Cl)C=C7Cl)C=C4",6.434,7,0,11]
["S2582","Trazodone HCl","g3","L4700-12","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Trazodone HCl (AF-1161, KB-831) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.",408.32,"25332-39-2",{"v":4,"d":"4.00"},{"v":9.8,"d":"9.80"},"<1",null,"http://selleckchem.com/products/trazodone-hydrochloride-desyrel.html","C19H22ClN5O.HCl","Hydrochloride","AF-1161, KB-831","Cl.ClC1=CC(=CC=C1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2",{"v":0,"d":"0.000"},0,0,0]
["S2893","NU7026","h3","L4700-12","in 2mM DMSO","Apoptosis related,DNA-PK,PI3K","DNA Damage/DNA Repair","NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.",281.31,"154447-35-5",{"v":1,"d":"1.00"},3.55,"<1",null,"http://selleckchem.com/products/nu7026.html","C17H15NO3","Free Base","LY293646","O=C1C=C(OC2=C1C=CC3=C2C=CC=C3)N4CCOCC4",2.732,3,0,1]
["S3041","Droxidopa","a4","L4700-12","in 2mM DMSO","Adrenergic Receptor","GPCR & G Protein","Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).",213.19,"23651-95-8",{"v":2,"d":"2.00"},9.38,{"v":1,"d":"1.00"},4.69,"http://www.selleck.cn/products/droxidopa-l-dops.html","C9H11NO5","Free Base","L-DOPS","NC(C(O)C1=CC(=C(O)C=C1)O)C(O)=O",-2.921,1,4,3]
["S3821","Nuciferine","b4","L4700-12","in 2mM DMSO","5-HT Receptor,5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.",295.38,"475-83-2",{"v":2,"d":"2.00"},6.77,"<1",null,"http://selleckchem.com/products/nuciferine.html","C19H21NO2","free base","Sanjoinine E, (-)-Nuciferine, VLT 049","COC1=C(OC)C2=C3C(CC4=C2C=CC=C4)N(C)CCC3=C1",3.567,2,0,2]
["S4218","Amoxapine","c4","L4700-12","in 2mM DMSO","Amino acid transporter,GlyT","Neuronal Signaling","Amoxapine (CL 67772,Asendin) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.",313.78,"14028-44-5",{"v":3,"d":"3.00"},9.56,"<1",null,"http://selleckchem.com/products/amoxapine.html","C17H16ClN3O","free base","CL 67772,Asendin","ClC1=CC2=C(OC3=C(C=CC=C3)N=C2N4CCNCC4)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5232","Alectinib (CH5424802) hydrochloride","d4","L4700-12","in 2mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.",519.08,"1256589-74-8",{"v":2,"d":"2.00"},3.85,"<1",null,"http://selleckchem.com/products/alectinib-hydrochloride.html","C30H34N4O2.HCl","hydrochloride","AF802, RO5424802, RG-7853","Cl.CCC1=C(C=C2C(=C1)C(=O)C3=C([NH]C4=C3C=CC(=C4)C#N)C2(C)C)N5CCC(CC5)N6CCOCC6",5.585,2,1,3]
["S5499","Amantadine","e4","L4700-12","in 2mM DMSO","Influenza Virus","Microbiology","Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.",151.25,"768-94-5",{"v":1,"d":"1.00"},6.61,null,null,"http://selleckchem.com/products/amantadine.html","C10H17N","free base","1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane","N[C]12C[CH]3[CH2]C([CH2][CH](C3)C1)C2",1.495,0,1,0]
["S8724","Lazertinib","f4","L4700-12","in 2mM DMSO","EGFR","Protein Tyrosine Kinase","Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.",554.64,"1903008-80-9",{"v":4,"d":"4.00"},7.21,"<1",null,"http://selleckchem.com/products/lazertinib-yh25448-gns-1480.html","C30H34N8O3","free base","YH25448,GNS-1480","COC1=CC(=C(NC(=O)C=C)C=C1NC2=NC=CC(=N2)[N]3C=C(CN(C)C)C(=N3)C4=CC=CC=C4)N5CCOCC5",{"v":4.56,"d":"4.560"},6,2,10]
["S3304","Stylopine","g4","L4700-12","in 2mM DMSO","COX,Interleukins,NOS,PGES,TNF-alpha","Immunology & Inflammation","Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.",323.34,"4312-32-7",{"v":2.5,"d":"2.50"},7.73,{"v":-1,"d":"-1.00"},null,"http://www.selleckchem.com/products/stylopine-trahydocoptisine-.html","C19H17NO4","free base","(R,S)-Stylopine, Tetrahydrocoptisine","C1OC2=CC3=C(C=C2O1)C4CC5=CC=C6OCOC6=C5CN4CC3",3.201,4,0,0]
["S9464","Tranylcypromine Sulfate","h4","L4700-12","in 2mM DMSO","MAO","Metabolism","Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.",364.46,"13492-01-8",{"v":2,"d":"2.00"},5.49,"<1",null,"http://www.selleckchem.com/products/tranylcypromine-sulfate.html","C18H24N2O4S","Sulfate","Parnate","NC1CC1C2=CC=CC=C2.NC3CC3C4=CC=CC=C4.O[S;v6](O)(=O)=O",{"v":1.78,"d":"1.780"},0,2,2]
["S2106","Azasetron HCl","a2","L4700-13","in 2mM Water","5-HT Receptor","Neuronal Signaling","Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.",386.27,"123040-16-4","<1",null,{"v":3,"d":"3.00"},7.77,"http://selleckchem.com/products/azasetron-hcl.html","C17H20ClN3O3.HCl","HCl","Y-25130 HCl","Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC3CN4CCC3CC4",1.616,3,1,2]
["S4226","Minocycline (CL 59806) HCl","b2","L4700-13","in 2mM Water","Antibiotics","Microbiology","Minocycline (CL 59806,Minocin) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.",493.94,"13614-98-7","<1",null,{"v":1,"d":"1.00"},2.02,"http://selleckchem.com/products/minocycline-hcl.html","C23H27N3O7.HCl","Hydrochloride","Minocin","Cl.CN(C)C1C2CC3CC4=C(C(=CC=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["S4694","Alosetron Hydrochloride","c2","L4700-13","in 2mM Water","5-HT Receptor","Neuronal Signaling","Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.",330.81,"122852-69-1","<1",null,{"v":1,"d":"1.00"},3.02,"http://selleckchem.com/products/alosetron-hydrochloride.html","C17H18N4O.HCl","hydrochloride","GR 68755C, GR 68755, GR 68755X, Lotronex, GR-68755, GR68755","Cl.C[N]1C2=C(C(=O)N(CC2)CC3=C(C)N=C[NH]3)C4=C1C=CC=C4",2.036,2,1,2]