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],[883,1,884,1],[883,2,884,2],[885,1,886,1],[885,2,886,2],[887,1,888,1],[887,2,888,2],[889,1,890,1],[889,2,890,2],[891,1,892,1],[891,2,892,2],[896,1,896,13],[898,1,899,1],[898,2,899,2],[900,1,901,1],[900,2,901,2],[902,1,903,1],[902,2,903,2],[904,1,905,1],[904,2,905,2],[906,1,907,1],[906,2,907,2],[908,1,909,1],[908,2,909,2],[910,1,911,1],[910,2,911,2],[912,1,913,1],[912,2,913,2],[917,1,917,13],[919,1,920,1],[919,2,920,2],[921,1,922,1],[921,2,922,2],[923,1,924,1],[923,2,924,2],[925,1,926,1],[925,2,926,2],[927,1,928,1],[927,2,928,2],[929,1,930,1],[929,2,930,2],[931,1,932,1],[931,2,932,2],[933,1,934,1],[933,2,934,2],[938,1,938,13],[940,1,941,1],[940,2,941,2],[942,1,943,1],[942,2,943,2],[944,1,945,1],[944,2,945,2],[946,1,947,1],[946,2,947,2],[948,1,949,1],[948,2,949,2],[950,1,951,1],[950,2,951,2],[952,1,953,1],[952,2,953,2],[954,1,955,1],[954,2,955,2],[959,1,959,13],[961,1,962,1],[961,2,962,2],[963,1,964,1],[963,2,964,2],[965,1,966,1],[965,2,966,2],[967,1,968,1],[967,2,968,2],[969,1,970,1],[969,2,970,2],[971,1,972,1],[971,2,972,2],[973,1,974,1],[973,2,974,2],[975,1,976,1],[975,2,976,2],[980,1,980,13],[982,1,983,1],[982,2,983,2],[984,1,985,1],[984,2,985,2],[986,1,987,1],[986,2,987,2],[988,1,989,1],[988,2,989,2],[990,1,991,1],[990,2,991,2],[992,1,993,1],[992,2,993,2],[994,1,995,1],[994,2,995,2],[996,1,997,1],[996,2,997,2],[1001,1,1001,13],[1003,1,1004,1],[1003,2,1004,2],[1005,1,1006,1],[1005,2,1006,2],[1007,1,1008,1],[1007,2,1008,2],[1009,1,1010,1],[1009,2,1010,2],[1011,1,1012,1],[1011,2,1012,2],[1013,1,1014,1],[1013,2,1014,2],[1015,1,1016,1],[1015,2,1016,2],[1017,1,1018,1],[1017,2,1018,2],[1022,1,1022,13],[1024,1,1025,1],[1024,2,1025,2],[1026,1,1027,1],[1026,2,1027,2],[1028,1,1029,1],[1028,2,1029,2],[1030,1,1031,1],[1030,2,1031,2],[1032,1,1033,1],[1032,2,1033,2],[1034,1,1035,1],[1034,2,1035,2],[1036,1,1037,1],[1036,2,1037,2],[1038,1,1039,1],[1038,2,1039,2],[1043,1,1043,13],[1045,1,1046,1],[1045,2,1046,2],[1047,1,1048,1],[1047,2,1048,2],[1049,1,1050,1],[1049,2,1050,2],[1051,1,1052,1],[1051,2,1052,2],[1053,1,1054,1],[1053,2,1054,2],[1055,1,1056,1],[1055,2,1056,2],[1057,1,1058,1],[1057,2,1058,2],[1059,1,1060,1],[1059,2,1060,2],[1064,1,1064,13],[1066,1,1067,1],[1066,2,1067,2],[1068,1,1069,1],[1068,2,1069,2],[1070,1,1071,1],[1070,2,1071,2],[1072,1,1073,1],[1072,2,1073,2],[1074,1,1075,1],[1074,2,1075,2],[1076,1,1077,1],[1076,2,1077,2],[1078,1,1079,1],[1078,2,1079,2],[1080,1,1081,1],[1080,2,1081,2],[1085,1,1085,13],[1087,1,1088,1],[1087,2,1088,2],[1089,1,1090,1],[1089,2,1090,2],[1091,1,1092,1],[1091,2,1092,2],[1093,1,1094,1],[1093,2,1094,2],[1095,1,1096,1],[1095,2,1096,2],[1097,1,1098,1],[1097,2,1098,2],[1099,1,1100,1],[1099,2,1100,2],[1101,1,1102,1],[1101,2,1102,2],[1106,1,1106,13],[1108,1,1109,1],[1108,2,1109,2],[1108,4,1109,4],[1108,5,1109,5],[1110,1,1111,1],[1110,2,1111,2],[1110,4,1111,4],[1110,5,1111,5],[1112,1,1113,1],[1112,2,1113,2],[1112,3,1113,3],[1112,4,1113,4],[1112,5,1113,5],[1114,1,1115,1],[1114,2,1115,2],[1114,3,1115,3],[1114,4,1115,4],[1114,5,1115,5],[1116,1,1117,1],[1116,2,1117,2],[1116,3,1117,3],[1116,4,1117,4],[1116,5,1117,5],[1118,1,1119,1],[1118,2,1119,2],[1118,3,1119,3],[1118,4,1119,4],[1118,5,1119,5],[1120,1,1121,1],[1120,2,1121,2],[1120,3,1121,3],[1120,4,1121,4],[1120,5,1121,5],[1122,1,1123,1],[1122,2,1123,2],[1122,3,1123,3],[1122,4,1123,4],[1122,5,1123,5],[1127,1,1127,13],[1129,1,1130,1],[1129,2,1130,2],[1131,1,1132,1],[1131,2,1132,2],[1133,1,1134,1],[1133,2,1134,2],[1135,1,1136,1],[1135,2,1136,2],[1137,1,1138,1],[1137,2,1138,2],[1139,1,1140,1],[1139,2,1140,2],[1141,1,1142,1],[1141,2,1142,2],[1143,1,1144,1],[1143,2,1144,2],[1148,1,1148,13],[1150,1,1151,1],[1150,2,1151,2],[1152,1,1153,1],[1152,2,1153,2],[1154,1,1155,1],[1154,2,1155,2],[1156,1,1157,1],[1156,2,1157,2],[1158,1,1159,1],[1158,2,1159,2],[1160,1,1161,1],[1160,2,1161,2],[1162,1,1163,1],[1162,2,1163,2],[1164,1,1165,1],[1164,2,1165,2],[1169,1,1169,13],[1171,1,1172,1],[1171,2,1172,2],[1171,5,1172,5],[1173,1,1174,1],[1173,2,1174,2],[1173,4,1174,4],[1173,5,1174,5],[1175,1,1176,1],[1175,2,1176,2],[1175,4,1176,4],[1175,5,1176,5],[1177,1,1178,1],[1177,2,1178,2],[1177,4,1178,4],[1177,5,1178,5],[1179,1,1180,1],[1179,2,1180,2],[1179,4,1180,4],[1181,1,1182,1],[1181,2,1182,2],[1181,4,1182,4],[1183,1,1184,1],[1183,2,1184,2],[1183,4,1184,4],[1185,1,1186,1],[1185,2,1186,2],[1185,4,1186,4]],"merged_total":1648,"flags":["merged_cut"]}
[{"$nulls":3},"Anti-cancer Compound Library  (96-well)-L3000"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 4249 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L3000-01~50;    In 2 mM DMSO : Plate layout L3000-54~55"]
[{"$nulls":3},"In 10 mM Water: Plate layout L3000-51~53;      In 2 mM Water  : Plate layout L3000-56"]
[]
[]
[null,"Plate layout: L3000-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1002","S1011","S1022","S1035","S1047","S1060","S1070","S1082","S1092","S1101","Empty"]
[{"$nulls":3},"ABT-737","Afatinib (BIBW2992)","Ridaforolimus (Deforolimus, MK-8669)","Pazopanib HCl (GW786034 HCl)","Vorinostat (SAHA)","Olaparib (AZD2281)","PHA-665752","Vismodegib (GDC-0449)","KU-55933 (ATM Kinase Inhibitor)","Vatalanib (PTK787) 2HCl"]
[null,"b","Empty","S1003","S1012","S1025","S1036","S1048","S1061","S1071","S1084","S1093","S1102","Empty"]
[{"$nulls":3},"Linifanib (ABT-869)","BMS-536924","Gefitinib (ZD1839)","Mirdametinib (PD0325901)","Tozasertib","Nutlin-3","HA14-1","Brivanib (BMS-540215)","GSK1904529A","U0126-EtOH"]
[null,"c","Empty","S1004","S1013","S1026","S1038","S1049","S1064","S1072","S1085","S1094","S1103","Empty"]
[{"$nulls":3},"Veliparib (ABT-888)","Bortezomib (PS-341)","Imatinib (STI571) Mesylate","PI-103","Y-27632 2HCl","Masitinib (AB1010)","ZSTK474","Belinostat (PXD101)","PF-04217903","ZM 447439"]
[null,"d","Empty","S1005","S1014","S1028","S1039","S1052","S1065","S1075","S1087","S1095","S1104","Empty"]
[{"$nulls":3},"Axitinib (AG 013736)","Bosutinib (SKI-606)","Lapatinib (GW-572016) Ditosylate","Rapamycin (AY-22989)","Elesclomol (STA-4783)","Pictilisib (GDC-0941)","SB216763","Iniparib (BSI-201)","Dacinostat (LAQ824)","GDC-0879"]
[null,"e","Empty","S1006","S1017","S1029","S1040","S1053","S1066","S1076","S1088","S1096","S1105","Empty"]
[{"$nulls":3},"Saracatinib (AZD0530)","Cediranib (AZD2171)","Lenalidomide (CC-5013)","Sorafenib (BAY 43-9006) tosylate","Entinostat (MS-275)","SL-327","Adezmapimod (SB203580)","NVP-ADW742","Quisinostat (JNJ-26481585) 2HCl","LY294002"]
[null,"f","Empty","S1007","S1018","S1030","S1041","S1055","S1067","S1077","S1089","S1097","S1106","Empty"]
[{"$nulls":3},"Roxadustat (FG-4592)","Dovitinib (TKI-258)","Panobinostat (LBH589)","STF-62247","Enzastaurin (LY317615)","SB431542","SB202190 (FHPI)","Refametinib (RDEA119)","BTZ043 Racemate","OSU-03012 (AR-12)"]
[null,"g","Empty","S1008","S1020","S1032","S1042","S1056","S1068","S1078","S1090","S1098","S1107","Empty"]
[{"$nulls":3},"Selumetinib (AZD6244)","PD184352 (CI-1040)","Motesanib Diphosphate (AMG-706)","Sunitinib (SU11248) malate","AC480 (BMS-599626)","Crizotinib (PF-02341066)","MK-2206 2HCl","Abexinostat (PCI-24781)","Rucaparib (AG-014699) phosphate","Danusertib (PHA-739358)"]
[null,"h","Empty","S1010","S1021","S1033","S1044","S1057","S1069","S1080","S1091","S1100","S1109","Empty"]
[{"$nulls":3},"Nintedanib (BIBF 1120)","Dasatinib (BMS-354825)","Nilotinib (AMN-107)","Temsirolimus (CCI-779)","Obatoclax Mesylate (GX15-070)","Luminespib (NVP-AUY922)","SU11274","Linsitinib (OSI-906)","MLN8054","BI 2536"]
[]
[]
[]
[null,"Plate layout: L3000-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1111","S1122","S1138","S1150","S1159","S1170","S1179","S1191","S1200","S1210","Empty"]
[{"$nulls":3},"Foretinib (GSK1363089)","Mocetinostat (MGCD0103)","Brivanib Alaninate (BMS-582664)","Paclitaxel (NSC 125973)","Ganetespib (STA-9090)","WZ3146","WZ8040","Fulvestrant (ICI-182780)","Decitabine (NSC 127716)","Methotrexate (CL-14377)"]
[null,"b","Empty","S1113","S1124","S1141","S1152","S1162","S1171","S1180","S1192","S1201","S1212","Empty"]
[{"$nulls":3},"GSK690693","BMS-754807","Tanespimycin (17-AAG)","PLX-4720","Pretomanid (PA-824)","CYC116","XAV-939","Raltitrexed","Dimesna","Bendamustine (SDX105) HCl"]
[null,"c","Empty","S1114","S1129","S1142","S1153","S1163","S1172","S1181","S1193","S1202","S1213","Empty"]
[{"$nulls":3},"JNJ-38877605","SRT1720 HCl","Alvespimycin (17-DMAG) HCl","Roscovitine (CYC202)","Onalespib (AT13387)","Serdemetan (JNJ-26854165)","ENMD-2076","Thalidomide (K17)","Dutasteride","Nelarabine"]
[null,"d","Empty","S1115","S1130","S1143","S1154","S1164","S1173","S1185","S1194","S1204","S1214","Empty"]
[{"$nulls":3},"Odanacatib (MK-0822)","Sepantronium Bromide","AG-490 (Tyrphostin B42)","SNS-314","Lenvatinib (E7080)","WZ4002","Ritonavir (ABT-538)","CUDC-101","Melatonin (NSC 113928)","Bleomycin (NSC125066) sulfate"]
[null,"e","Empty","S1117","S1132","S1144","S1155","S1165","S1175","S1186","S1195","S1206","S1216","Empty"]
[{"$nulls":3},"Triciribine (NSC 154020)","3-Aminobenzamide","Ivacaftor (VX-770)","S3I-201","ABT-751 (E7010)","BIIB021","BIBR 1532","Orteronel","Bisoprolol fumarate","PFI-1 (PF-6405761)"]
[null,"f","Empty","S1119","S1133","S1145","S1156","S1167","S1176","S1188","S1196","S1207","S1218","Empty"]
[{"$nulls":3},"Cabozantinib (BMS-907351)","Alisertib (MLN8237)","SNS-032 (BMS-387032)","Capecitabine (RO 09-1978)","CP-724714","Plinabulin (NPI-2358)","Anastrozole (ZD-1033)","Exemestane (FCE 24304)","Tivozanib (AV-951)","Clofarabine"]
[null,"g","Empty","S1120","S1134","S1147","S1157","S1168","S1177","S1189","S1197","S1208","S1219","Empty"]
[{"$nulls":3},"Everolimus (RAD001)","AT9283","Barasertib (AZD1152-HQPA)","Delanzomib (CEP-18770)","Valproic Acid (NSC 93819) sodium salt","PD98059","Aprepitant (MK-0869)","Finasteride","Doxorubicin (Adriamycin) HCl","YM201636"]
[null,"h","Empty","S1121","S1137","S1148","S1158","S1169","S1178","S1190","S1199","S1209","S1220","Empty"]
[{"$nulls":3},"TW-37","Malotilate","Docetaxel (RP56976)","MK-8245","TGX-221","Regorafenib (BAY 73-4506)","Bicalutamide (ICI-176334)","Cladribine (RWJ 26251)","Fluorouracil (5-Fluorouracil, 5-FU)","OSI-930"]
[]
[]
[]
[null,"Plate layout: L3000-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1221","S1231","S1244","S1259","S1271","S1283","S1297","S1322","S1334","S1354","Empty"]
[{"$nulls":3},"Dacarbazine (NSC-45388)","Topotecan (NSC609699) HCl","Amuvatinib (MP-470)","Ramelteon","Acarbose","Asenapine maleate","Epothilone A","Dexamethasone (MK-125)","Flupirtine maleate","Lansoprazole"]
[null,"b","Empty","S1222","S1233","S1245","S1260","S1274","S1284","S1299","S1324","S1336","S1357","Empty"]
[{"$nulls":3},"Dexrazoxane HCl (ICRF-187)","2-Methoxyestradiol (2-MeOE2)","Latrepirdine 2HCl","Cinacalcet (AMG-073) HCl","BX-795","Benazepril HCl","Floxuridine (NSC 27640)","Doxazosin Mesylate","Fluvoxamine (DU-23000) maleate","Lidocaine"]
[null,"c","Empty","S1223","S1234","S1247","S1261","S1275","S1287","S1300","S1326","S1340","S1358","Empty"]
[{"$nulls":3},"Epirubicin (IMI 28) HCl","AG-1024","Leflunomide (HWA486)","Celecoxib (SC 58635)","BX-912","Bumetanide","Tegafur (FT-207)","Edaravone","Gatifloxacin","Loratadine (SCH29851)"]
[null,"d","Empty","S1225","S1235","S1249","S1262","S1276","S1289","S1302","S1328","S1342","S1359","Empty"]
[{"$nulls":3},"Etoposide (VP-16)","Letrozole (CGS 20267)","JNJ-7706621","Avagacestat (BMS-708163)","Adapalene","Carmofur","Ifosfamide (NSC109724)","Etodolac","Genistein (NPI 031L)","Losartan Potassium (DuP 753)"]
[null,"e","Empty","S1226","S1237","S1250","S1263","S1278","S1290","S1304","S1330","S1343","S1361","Empty"]
[{"$nulls":3},"KU-0063794","Temozolomide (CCRG 81045)","Enzalutamide (MDV3100)","Laduviglusib (CHIR-99021)","Altretamine","Celastrol (NSC 70931)","Megestrol Acetate","Felbamate","Ginkgolide B","MGCD-265 analog"]
[null,"f","Empty","S1227","S1238","S1251","S1264","S1280","S1291","S1305","S1331","S1344","S1362","Empty"]
[{"$nulls":3},"Raloxifene HCl","Tamoxifen (ICI 46474)","Dienogest","PD173074","Amisulpride","Cetirizine DiHCl","Mercaptopurine (6-MP)","Fluconazole (UK 49858)","Glimepiride","Rigosertib (ON-01910)"]
[null,"g","Empty","S1229","S1241","S1255","S1266","S1281","S1292","S1315","S1332","S1351","S1363","Empty"]
[{"$nulls":3},"Fludarabine Phosphate","Vincristine (NSC-67574) sulfate","Nepafenac","WYE-354","Aniracetam","Chelerythrine Chloride (NSC 646662)","Ki16425","Flumazenil (RO 15-1788)","Ivermectin (MK-933)","Ki8751"]
[null,"h","Empty","S1230","S1243","S1257","S1267","S1282","S1294","S1319","S1333","S1352","S1364","Empty"]
[{"$nulls":3},"Flavopiridol (L86-8275)","Agomelatine (S20098)","Posaconazole (SCH 56592)","Vemurafenib (PLX4032)","Artemisinin","Cilostazol (OPC-13013)","Costunolide","Fluoxetine (Lilly 110140) HCl","TG100-115","Patupilone (Epothilone B)"]
[]
[]
[]
[null,"Plate layout: L3000-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1366","S1379","S1393","S1405","S1431","S1444","S1458","S1474","S1486","S1500","Empty"]
[{"$nulls":3},"BMS-707035","Isotretinoin","Pirarubicin (NSC-333054)","Vecuronium Bromide","Sildenafil Citrate","Ziprasidone HCl","Neflamapimod (VX-745)","GSK429286A","AEE788 (NVP-AEE788)","Betamethasone"]
[null,"b","Empty","S1367","S1385","S1394","S1407","S1432","S1445","S1459","S1475","S1487","S1501","Empty"]
[{"$nulls":3},"Amonafide","Mosapride Citrate","Pizotifen Malate","Bimatoprost","Sumatriptan Succinate","Zonisamide","Thiazovivin","Pimasertib (AS-703026)","PHA-793887","Mycophenolate mofetil (RS-61443)"]
[null,"c","Empty","S1368","S1386","S1396","S1408","S1437","S1451","S1460","S1476","S1488","S1504","Empty"]
[{"$nulls":3},"Acitretin","Nafamostat mesilate (FUT-175)","Resveratrol (SRT501)","Linezolid (PNU-100766)","Tizanidine HCl","Aurora A Inhibitor I (TC-S 7010)","SP600125","SB525334","Naratriptan HCl","Dyphylline"]
[null,"d","Empty","S1369","S1387","S1397","S1409","S1438","S1452","S1462","S1480","S1489","S1505","Empty"]
[{"$nulls":3},"Bafetinib (INNO-406)","Naftopidil DiHCl","Rocuronium Bromide","Alfuzosin HCl","Topiramate","Ispinesib (SB-715992)","AZD6482","Lomibuvir (VX-222)","PIK-93","Aztreonam"]
[null,"e","Empty","S1373","S1389","S1398","S1422","S1439","S1453","S1465","S1481","S1490","S1512","Empty"]
[{"$nulls":3},"Daptomycin (LY146032)","Omeprazole","Stavudine (d4T)","Droxinostat","Tranilast (SB 252218)","Tipifarnib (R115777)","Moxifloxacin (BAY12-8039) HCl","Zosuquidar (LY335979) 3HCl","Ponatinib (AP24534)","Tadalafil (IC351)"]
[null,"f","Empty","S1376","S1390","S1401","S1425","S1441","S1454","S1467","S1483","S1491","S1515","Empty"]
[{"$nulls":3},"Gestodene","Ondansetron HCl","Tenofovir","Ranolazine 2HCl","Venlafaxine HCl","PHA-680632","Doxercalciferol","Iloperidone","Fludarabine (NSC 118218)","Pracinostat (SB939)"]
[null,"g","Empty","S1377","S1391","S1403","S1426","S1442","S1456","S1468","S1484","S1497","S1517","Empty"]
[{"$nulls":3},"Drospirenone","Oxcarbazepine","Tigecycline (GAR-936)","Repaglinide","Voriconazole (UK-109496)","Zibotentan (ZD4054)","Alfacalcidol","MC1568","Pralatrexate (NSC 754230)","Natamycin"]
[null,"h","Empty","S1378","S1392","S1404","S1430","S1443","S1457","S1470","S1485","S1499","S1523","Empty"]
[{"$nulls":3},"Ruxolitinib (INCB018424)","Pelitinib (EKB-569)","Trilostane","Rolipram (ZK-62711)","Zileuton (A-64077)","Atazanavir (BMS-232632) Sulfate","Orantinib (SU6668)","HMN-214","Cefaclor","Voxtalisib (XL765) Analogue"]
[]
[]
[]
[null,"Plate layout: L3000-05"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1524","S1536","S1556","S1570","S1590","S1606","S1626","S1638","S1649","S1666","Empty"]
[{"$nulls":3},"AT7519","CP-673451","PHT-427","KU-60019","TWS119","Clotrimazole","Naproxen Sodium","Ibuprofen (NSC 256857)","Zolmitriptan","Flucytosine"]
[null,"b","Empty","S1525","S1537","S1557","S1572","S1591","S1607","S1627","S1639","S1651","S1667","Empty"]
[{"$nulls":3},"Adavosertib (MK-1775)","Vadimezan (ASA404)","KRN 633","BS-181 HCl","Bestatin (NK421)","Rizatriptan Benzoate","Nitazoxanide (NSC 697855)","Amprenavir (VX-478)","Telbivudine","Trichlormethiazide"]
[null,"c","Empty","S1526","S1541","S1558","S1573","S1593","S1608","S1628","S1640","S1652","S1679","Empty"]
[{"$nulls":3},"Quizartinib (AC220)","Selisistat (EX 527)","AT7867","Fasudil (HA-1077) HCl","Apixaban (BMS 562247-01)","Pyridostigmine Bromide","Triamcinolone Acetonide","Albendazole (SKF-62979)","Monobenzone","Flurbiprofen"]
[null,"d","Empty","S1528","S1547","S1561","S1574","S1594","S1613","S1629","S1641","S1653","S1680","Empty"]
[{"$nulls":3},"LY2811376","Febuxostat","BMS-777607","Doramapimod (BIRB 796)","Semagacestat (LY450139)","Silodosin","Orlistat (Ro 18-0647)","Chlorothiazide","Tretinoin (NSC 122758)","Disulfiram (NSC 190940)"]
[null,"e","Empty","S1529","S1548","S1565","S1576","S1601","S1614","S1630","S1643","S1654","S1681","Empty"]
[{"$nulls":3},"Hesperadin","Dapagliflozin (BMS-512148)","Lumacaftor (VX-809)","Sulfasalazine (NSC 667219)","Reserpine","Riluzole (PK 26124)","Allopurinol","Ursodiol","Phenylbutazone","Mesalamine (5-ASA)"]
[null,"f","Empty","S1530","S1549","S1567","S1577","S1603","S1618","S1631","S1644","S1655","S1683","Empty"]
[{"$nulls":3},"BIX 02188","Nebivolol hydrochloride (R-65824)","Pomalidomide (CC-4047)","Tie2 kinase inhibitor","Furosemide (NSC 269420)","Sulfameter","Allopurinol Sodium","Nitrofural","Ezetimibe (SCH-58235)","Ipratropium Bromide"]
[null,"g","Empty","S1532","S1550","S1568","S1578","S1604","S1622","S1633","S1645","S1658","S1685","Empty"]
[{"$nulls":3},"AZD7762","Pimobendan","PD318088","Candesartan (CV-11974)","Olmesartan Medoxomil","Prednisone (NSC-10023)","Zafirlukast (ICI-204219)","Ketoprofen","Dofetilide","Sulfanilamide"]
[null,"h","Empty","S1533","S1555","S1569","S1582","S1605","S1625","S1635","S1647","S1665","S1688","Empty"]
[{"$nulls":3},"R406 (free base)","AZD8055","Tazarotene","H 89 2HCl","Cefdinir","Ethinyl Estradiol","Erythromycin","Adenosine","Estrone","Betamethasone Dipropionate"]
[]
[]
[]
[null,"Plate layout: L3000-06"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1689","S1706","S1723","S1736","S1759","S1774","S1787","S1805","S1829","S1847","Empty"]
[{"$nulls":3},"Meprednisone","Lamivudine (BCH-189)","Indomethacin (NSC-77541)","Methocarbamol","Pitavastatin (NK-104) calcium","Thioguanine (NSC 752)","Teniposide","Acetylcholine Chloride","Pranlukast","Clemastine (HS-592) fumarate"]
[null,"b","Empty","S1690","S1709","S1727","S1738","S1760","S1775","S1790","S1806","S1830","S1848","Empty"]
[{"$nulls":3},"Betamethasone Valerate","Estradiol","Levonorgestrel","Telmisartan","Rifapentine","Thiotepa","Rifaximin","Acipimox","Oxfendazole","Curcumin"]
[null,"c","Empty","S1692","S1712","S1729","S1739","S1761","S1776","S1792","S1808","S1831","S1849","Empty"]
[{"$nulls":3},"Busulfan (NSC-750)","Deferasirox (ICL-670)","Gemfibrozil","Thiabendazole","Suprofen","Toremifene Citrate (NK 622)","Simvastatin (MK 733)","Nifedipine (BAY-a-1040)","Carvedilol","Daidzein"]
[null,"d","Empty","S1693","S1713","S1730","S1741","S1763","S1777","S1793","S1811","S1833","S1854","Empty"]
[{"$nulls":3},"Carbamazepine","Piroxicam","Indapamide","Rifabutin (LM427)","Quetiapine (ICI-204636) fumarate","Ethionamide","Ramipril","Amiloride (MK-870) HCl","Butoconazole nitrate","Bifonazole"]
[null,"e","Empty","S1696","S1714","S1732","S1742","S1764","S1778","S1794","S1816","S1835","S1855","Empty"]
[{"$nulls":3},"Hydrocortisone (NSC 10483)","Gemcitabine (LY-188011)","Mitotane","Nevirapine (NSC 641530)","Rifampin (NSC-113926)","Trifluridine (NSC 75520)","Fenofibrate (NSC-281319)","Chlorpheniramine Maleate","Azithromycin (CP-62993)","Pefloxacin Mesylate"]
[null,"f","Empty","S1701","S1715","S1733","S1747","S1768","S1782","S1799","S1820","S1839","S1856","Empty"]
[{"$nulls":3},"Desonide","Glipizide","Methylprednisolone (NSC-19987)","Nimodipine","Cefditoren Pivoxil","Azacitidine (5-Azacytidine)","Ranolazine","Clofibrate","Chloroxine","Metoprolol Tartrate"]
[null,"g","Empty","S1702","S1718","S1734","S1754","S1770","S1784","S1801","S1827","S1840","S1858","Empty"]
[{"$nulls":3},"Didanosine","Adefovir Dipivoxil (GS 0840)","Meloxicam","Oxybutynin","Sulfadiazine","Vidarabine","Ranitidine Hydrochloride","Betaxolol HCl","Lomustine","Dienestrol"]
[null,"h","Empty","S1705","S1721","S1735","S1756","S1771","S1786","S1802","S1828","S1845","S1859","Empty"]
[{"$nulls":3},"Progesterone (NSC 9704)","Azathioprine","Mesna","Enoxacin","Chlorprothixene","Verteporfin (CL 318952)","AICAR (Acadesine)","Proparacaine HCl","Cimetidine","Diethylstilbestrol"]
[]
[]
[]
[null,"Plate layout: L3000-07"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1869","S1895","S1913","S1937","S1969","S1992","S2017","S2032","S2053","S2067","Empty"]
[{"$nulls":3},"Dapoxetine HCl","Dipyridamole (NSC 515776)","Tropicamide","Isoniazid","Nefiracetam","Fluticasone propionate","Benidipine HCl","Rebamipide","Cytidine","Ozagrel HCl"]
[null,"b","Empty","S1878","S1896","S1914","S1941","S1971","S2003","S2018","S2037","S2055","S2069","Empty"]
[{"$nulls":3},"Ganciclovir (BW 759)","Hydroxyurea (NSC-32065)","Pregnenolone","Enalapril Maleate","Nicorandil","Maraviroc (UK-427857)","ENMD-2076 L-(+)-Tartaric acid","Candesartan Cilexetil","Gimeracil","Argatroban (MCI-9038)"]
[null,"c","Empty","S1880","S1899","S1915","S1949","S1972","S2006","S2020","S2038","S2057","S2072","Empty"]
[{"$nulls":3},"Roxatidine Acetate HCl","Nicotinamide (NSC 13128)","Sulfamethoxazole","Menadione (NSC 4170)","Tamoxifen (ICI 46474) Citrate","Pyrimethamine","Formoterol Hemifumarate","Phentolamine Mesylate","Cyclophosphamide (NSC-26271) Monohydrate","Seratrodast(AA-2414)"]
[null,"d","Empty","S1883","S1903","S1916","S1950","S1973","S2007","S2024","S2040","S2058","S2077","Empty"]
[{"$nulls":3},"Idoxuridine","Diclofenac Sodium","Sulfisoxazole","Metformin HCl","Cyclocytidine HCl","Sulindac","Ketotifen Fumarate","Nimesulide","Tolnaftate","Atorvastatin Calcium"]
[null,"e","Empty","S1884","S1907","S1917","S1952","S1975","S2012","S2025","S2042","S2059","S2078","Empty"]
[{"$nulls":3},"Sparfloxacin","Metronidazole","Crystal Violet","Methoxsalen","Aripiprazole","PCI-34051","Urapidil HCl","Cyproterone Acetate","Terazosin HCl Dihydrate","Famotidine"]
[null,"f","Empty","S1888","S1908","S1920","S1957","S1978","S2013","S2026","S2045","S2061","S2080","Empty"]
[{"$nulls":3},"Deflazacort","Flutamide","Haloperidol","Sulfamethizole","Methscopolamine","PF-573228","Ginkgolide A","Doxifluridine","Lovastatin (MK-803)","Clevidipine Butyrate"]
[null,"g","Empty","S1890","S1909","S1933","S1959","S1979","S2014","S2028","S2046","S2064","S2082","Empty"]
[{"$nulls":3},"Nizatidine","Fluvastatin (XU-62-320) Sodium","Triamcinolone","Tolfenamic Acid","Amiodarone (NSC 85442) HCl","BMS-265246","Diclazuril","Pioglitazone HCl","Balofloxacin","Adiphenine HCl"]
[null,"h","Empty","S1894","S1910","S1934","S1965","S1990","S2015","S2029","S2051","S2065","S2086","Empty"]
[{"$nulls":3},"Valsartan (CGP-48933)","Tioconazole","Nystatin (Fungicidin)","Primidone","Capsaicin(Vanilloid)","Suplatast Tosylate","Uridine","Captopril","Lafutidine","Ivabradine HCl"]
[]
[]
[]
[null,"Plate layout: L3000-08"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2087","S2105","S2125","S2151","S2162","S2179","S2192","S2202","S2220","S2230","Empty"]
[{"$nulls":3},"Rivastigmine Tartrate","Pantoprazole","Mestranol","Sonidegib (NVP-LDE225)","AZD1480","Gandotinib (LY2784544)","Sapitinib (AZD8931)","NVP-BHG712","SB590885","Galunisertib (LY2157299)"]
[null,"b","Empty","S2090","S2108","S2126","S2153","S2163","S2180","S2193","S2205","S2222","S2231","Empty"]
[{"$nulls":3},"Dexmedetomidine HCl","Flunixin Meglumin","Naftopidil","CGS 21680 HCl","PF-4708671","Ixazomib (MLN2238)","GSK461364","OSI-420","PF-3716556","Telatinib"]
[null,"c","Empty","S2096","S2109","S2127","S2154","S2167","S2181","S2194","S2214","S2224","S2233","Empty"]
[{"$nulls":3},"Almotriptan Malate","Imidapril HCl","S-(+)-Rolipram","Dabigatran (BIBR-1048) etexilate","Bazedoxifene (TSE-424) acetate","Ixazomib Citrate (MLN9708) Analogue","R406","AZ 960","UK 383367","Esomeprazole sodium"]
[null,"d","Empty","S2098","S2111","S2128","S2155","S2169","S2182","S2195","S2215","S2225","S2235","Empty"]
[{"$nulls":3},"Bexarotene (LGD1069)","Lapatinib (GW-572016)","Bazedoxifene (WAY-140424) HCl","LY2608204","Rosuvastatin (ZD4522) calcium","SB743921 HCl","Lexibulin (CYT997)","DAPT (GSI-IX)","TAME","Volasertib (BI 6727)"]
[null,"e","Empty","S2099","S2113","S2130","S2156","S2170","S2183","S2197","S2216","S2226","S2238","Empty"]
[{"$nulls":3},"Temocapril HCl","Cisatracurium Besylate","Atropine sulfate monohydrate","LY2886721","Givinostat (ITF2357)","Infigratinib (BGJ398)","A-966492","Mubritinib (TAK 165)","Idelalisib","Palomid 529 (P529)"]
[null,"f","Empty","S2101","S2114","S2131","S2158","S2173","S2185","S2198","S2217","S2227","S2243","Empty"]
[{"$nulls":3},"Gabexate Mesylate","Dronedarone HCl","Roflumilast (B9302-107)","KW-2449","Telotristat Etiprate (LX 1606 Hippurate)","Allitinib tosylate","SGI-1776 free base","Irinotecan (CPT-11) HCl Trihydrate","PIK-294","Degrasyn (WP1130)"]
[null,"g","Empty","S2102","S2118","S2134","S2160","S2177","S2186","S2199","S2218","S2228","S2244","Empty"]
[{"$nulls":3},"Rasagiline Mesylate","Ibutilide Fumarate","AZD8330","Almorexant HCl","Dichlorphenamide","SB505124","Aliskiren Hemifumarate","Torkinib (PP242)","Belnacasan (VX-765)","AR-42"]
[null,"h","Empty","S2103","S2119","S2149","S2161","S2178","S2187","S2201","S2219","S2229","S2246","Empty"]
[{"$nulls":3},"Naltrexone HCl","Probucol","GSK1292263","RAF265 (CHIR-265)","AG-14361","Avasimibe (CI-1011)","BMS-794833","Momelotinib (CYT387)","Eltrombopag (SB497115) Olamine","Abiraterone Acetate (CB7630)"]
[]
[]
[]
[null,"Plate layout: L3000-09"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2247","S2260","S2269","S2285","S2299","S2308","S2319","S2328","S2338","S2350","Empty"]
[{"$nulls":3},"Buparlisib (BKM120)","Amygdalin","Baicalin (NSC-661431)","Cryptotanshinone","Formononetin","Hesperetin","Limonin","Nalidixic acid","Oxymatrine","Rutin"]
[null,"b","Empty","S2248","S2261","S2270","S2286","S2300","S2309","S2320","S2329","S2341","S2351","Empty"]
[{"$nulls":3},"Silmitasertib (CX-4945)","Andrographolide","Bergenin","Cyclosporin A (NSC 290193)","Ferulic Acid","Hesperidin","Luteolin","Naringin","(-)-Parthenolide","Salicin"]
[null,"c","Empty","S2250","S2262","S2271","S2287","S2301","S2310","S2321","S2332","S2342","S2354","Empty"]
[{"$nulls":3},"(-)-Epigallocatechin Gallate","Apigenin (LY 080400)","Berberine chloride (NSC 646666)","Cytisine","Genistin (Genistoside)","Honokiol (NSC 293100)","Magnolol","Neohesperidin","Phloretin (RJC 02792)","Sclareol"]
[null,"d","Empty","S2252","S2263","S2277","S2289","S2302","S2311","S2322","S2333","S2344","S2357","Empty"]
[{"$nulls":3},"(+)-Usniacin","Arbutin","Caffeic Acid","Daidzin","Glycyrrhizin (NSC 167409)","Hyodeoxycholic acid (HDCA)","(+)-Matrine","Nobiletin (NSC 76751)","Piperine","Silibinin (NSC 651520)"]
[null,"e","Empty","S2254","S2264","S2280","S2290","S2303","S2312","S2323","S2334","S2346","S2358","Empty"]
[{"$nulls":3},"4-Demethylepipodophyllotoxin(NSC-122819,VM-26)","Artemether","Chlorogenic Acid","Dihydroartemisinin (DHA)","Gossypol Acetate","Icariin","Methyl-Hesperidin","Oleanolic Acid","Puerarin","Silymarin"]
[null,"f","Empty","S2256","S2265","S2281","S2295","S2304","S2313","S2325","S2335","S2347","S2362","Empty"]
[{"$nulls":3},"4-Methylumbelliferone (4-MU)","Artesunate (WR-256283)","Chrysin","Emodin","Gramine","Indole-3-carbinol","Morin Hydrate","Oridonin (NSC-250682)","Quercetin Dihydrate","Synephrine"]
[null,"g","Empty","S2258","S2266","S2283","S2296","S2305","S2314","S2326","S2336","S2348","S2363","Empty"]
[{"$nulls":3},"Esculin","Asiatic Acid","Cinchonine(LA40221)","Enoxolone","Grape Seed Extract","Kaempferol (NSC 407289)","Myricetin","Orotic acid (6-Carboxyuracil)","Rotenone (Barbasco)","Tangeretin"]
[null,"h","Empty","S2259","S2268","S2284","S2298","S2306","S2318","S2327","S2337","S2349","S2364","Empty"]
[{"$nulls":3},"Aloe-emodin","Baicalein","Colchicine (NSC 757)","Fisetin","Gynostemma Extract","Lappaconitine","Myricitrin","Osthole","Rutaecarpine","Tanshinone I"]
[]
[]
[]
[null,"Plate layout: L3000-10"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2365","S2378","S2389","S2401","S2412","S2443","S2466","S2481","S2494","S2508","Empty"]
[{"$nulls":3},"Tanshinone IIA","Butylscopolamine Bromide","Naringin Dihydrochalcone","Sodium Danshensu","Genipin","Tolbutamide (HLS 831)","Estriol","Manidipine","Olopatadine HCl","Scopolamine (LSM-4015) HBr"]
[null,"b","Empty","S2366","S2379","S2390","S2403","S2413","S2448","S2467","S2484","S2496","S2509","Empty"]
[{"$nulls":3},"Taxifolin (Dihydroquercetin)","Dioscin","Polydatin","Tetrandrine (NSC-77037)","Geniposidic acid","Gambogic Acid","Famciclovir","Milrinone","Ozagrel","Sotalol HCl"]
[null,"c","Empty","S2369","S2380","S2391","S2404","S2415","S2449","S2468","S2485","S2497","S2511","Empty"]
[{"$nulls":3},"Troxerutin","Diosmetin","Quercetin (NSC 9221)","Isoliquiritigenin","Astragaloside A","Colforsin","Fenbendazole","Mitoxantrone (NSC-301739) 2HCl","Pancuronium dibromide","Sulfadoxine"]
[null,"d","Empty","S2370","S2382","S2394","S2405","S2422","S2450","S2470","S2486","S2499","S2512","Empty"]
[{"$nulls":3},"Ursolic Acid","Evodiamine","Naringenin","Sophocarpine","Ipriflavone (Osteofix)","Equol","Fluocinolone Acetonide","Moroxydine HCl","Phenoxybenzamine HCl","Tenoxicam"]
[null,"e","Empty","S2371","S2383","S2396","S2406","S2423","S2455","S2471","S2487","S2502","S2515","Empty"]
[{"$nulls":3},"Vanillylacetone","Gastrodin","Salidroside","Chrysophanic Acid","(S)-10-Hydroxycamptothecin","Bethanechol chloride","Gallamine Triethiodide","Mycophenolic acid","Quinine HCl Dihydrate","Vardenafil HCl Trihydrate"]
[null,"f","Empty","S2375","S2386","S2397","S2407","S2425","S2456","S2473","S2489","S2503","S2516","Empty"]
[{"$nulls":3},"Aloin","Indirubin (NSC 105327)","Palmatine chloride","Curcumol","Apocynin (NSC 2146)","Chlorpromazine HCl","Hexestrol","Nateglinide","Racecadotril","Xylazine HCl"]
[null,"g","Empty","S2376","S2387","S2399","S2408","S2438","S2458","S2475","S2492","S2504","S2517","Empty"]
[{"$nulls":3},"Ammonium Glycyrrhizinate","Lappaconite HBr","Dihydromyricetin","Cephalomannine","Synephrine HCl","Clonidine HCl","Imatinib (STI571)","Novobiocin Sodium (NSC 2382)","Ribavirin (ICN-1229)","Maprotiline HCl"]
[null,"h","Empty","S2377","S2388","S2400","S2409","S2439","S2461","S2480","S2493","S2505","S2519","Empty"]
[{"$nulls":3},"Biochanin A","L-carnitine","Rheic Acid","10-Deacetylbaccatin-III","Guanosine","Domperidone","Loperamide HCl","Olanzapine","Rosiglitazone (BRL-49653) maleate","Naphazoline HCl"]
[]
[]
[]
[null,"Plate layout: L3000-11"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2526","S2541","S2556","S2576","S2593","S2615","S2626","S2658","S2670","S2686","Empty"]
[{"$nulls":3},"Alizarin","Clomipramine HCl","Rosiglitazone (BRL 49653)","Xylometazoline HCl","Tolvaptan","Noradrenaline bitartrate monohydrate","Rabusertib (LY2603618)","Omipalisib (GSK2126458)","A-674563","NVP-BSK805 2HCl"]
[null,"b","Empty","S2528","S2543","S2559","S2577","S2601","S2617","S2627","S2660","S2671","S2688","Empty"]
[{"$nulls":3},"Ciclopirox","Ceftiofur HCl","Cortisone acetate","Phenacetin","Gliclazide","TAK-733","Tubastatin A HCl","MK-0752","AS-252424","R547"]
[null,"c","Empty","S2529","S2545","S2561","S2579","S2602","S2619","S2630","S2661","S2672","S2689","Empty"]
[{"$nulls":3},"Dopamine HCl","Scopine","Clomifene citrate","Zidovudine","Acemetacin","MG132","GW3965 HCl","WYE-125132 (WYE-132)","PF-00562271 Besylate","WAY-600"]
[null,"d","Empty","S2532","S2549","S2564","S2581","S2603","S2621","S2634","S2662","S2673","S2692","Empty"]
[{"$nulls":3},"L-Ascorbyl 6-palmitate","Trospium chloride","Cloxacillin Sodium","Quinapril HCl","Tioxolone","AZD5438","Rebastinib (DCC-2036)","Foscenvivint (ICG-001)","Trametinib (GSK1120212)","TG101209"]
[null,"e","Empty","S2533","S2552","S2566","S2584","S2606","S2622","S2635","S2663","S2679","S2693","Empty"]
[{"$nulls":3},"Ritodrine HCl","Azelastine HCl","Isoprenaline (NCI-C55630) HCl","Clobetasol propionate","Mifepristone (RU486)","PP121","CCT128930","WAY-100635 Maleate","Flavopiridol (L86-8275) HCl","Resminostat"]
[null,"f","Empty","S2535","S2553","S2567","S2585","S2607","S2623","S2636","S2664","S2680","S2694","Empty"]
[{"$nulls":3},"Econazole nitrate","5-Aminolevulinic acid HCl","Medroxyprogesterone acetate (NSC-26386)","Brompheniramine hydrogen maleate","Buflomedil HCl","Omecamtiv mecarbil (CK-1827452)","A66","Clinofibrate","Ibrutinib (PCI-32765)","Turofexorate Isopropyl (XL335)"]
[null,"g","Empty","S2536","S2554","S2569","S2586","S2610","S2624","S2639","S2665","S2683","S2695","Empty"]
[{"$nulls":3},"Miconazole","Daphnetin","Phenylephrine (NCI-C55641) HCl","Dimethyl Fumarate","Lonidamine (AF-1890)","OSI-027","SNX-2112 (PF-04928473)","Ciprofibrate","CHIR-124","Nepicastat (SYN-117) HCl"]
[null,"h","Empty","S2537","S2555","S2570","S2590","S2611","S2625","S2656","S2666","S2685","S2696","Empty"]
[{"$nulls":3},"Secnidazole","Clarithromycin","Prednisolone Acetate","Pioglitazone (AD-4833)","Ethisterone","Fostamatinib (R788)","PF-04929113 (SNX-5422)","PF-3845","KW-2478","Apitolisib (GDC-0980)"]
[]
[]
[]
[null,"Plate layout: L3000-12"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2697","S2719","S2736","S2747","S2757","S2772","S2780","S2791","S2806","S2817","Empty"]
[{"$nulls":3},"A-769662","AMG-900","Fedratinib (TG101348)","AMG-458","Evofosfamide (TH-302)","Dalcetrapib (JTT-705)","I-BET151 (GSK1210151A)","Sotrastaurin (AEB071)","CEP-33779","Torin 2"]
[null,"b","Empty","S2699","S2720","S2738","S2749","S2759","S2773","S2781","S2792","S2807","S2818","Empty"]
[{"$nulls":3},"CH5132799","ZM 336372","PAC-1","BGT226 (NVP-BGT226) maleate","Fimepinostat (CUDC-907)","SB705498","RITA (NSC 652287)","Torcetrapib","Dabrafenib (GSK2118436)","Tacedinaline (CI994)"]
[null,"c","Empty","S2700","S2722","S2740","S2750","S2760","S2774","S2782","S2796","S2808","S2819","Empty"]
[{"$nulls":3},"Tirbanibulin","JTC-801","GSK1070916","GW788388","Canagliflozin (JNJ 28431754)","MK-2461","GW4064","WP1066","Ipatasertib (GDC-0068)","AM251"]
[null,"d","Empty","S2703","S2726","S2741","S2751","S2761","S2775","S2783","S2797","S2811","S2820","Empty"]
[{"$nulls":3},"GSK1838705A","PH-797804","Niraparib (MK-4827)","Milciclib (PHA-848125)","NVP-BVU972","Nocodazole (R17934)","Vistusertib (AZD2014)","Lonafarnib (SCH66336)","Sapanisertib (MLN0128)","TAE226 (NVP-TAE226)"]
[null,"e","Empty","S2711","S2727","S2742","S2752","S2762","S2776","S2784","S2799","S2812","S2821","Empty"]
[{"$nulls":3},"Dibenzazepine (YO-01027)","Dacomitinib (PF-00299804)","PHA-767491 HCl","HER2-Inhibitor-1","Alectinib (CH5424802)","Devimistat (CPI-613)","TAK-285","Daporinad","(R)-(-)-Gossypol acetic acid","RG108"]
[null,"f","Empty","S2713","S2728","S2743","S2753","S2768","S2777","S2785","S2801","S2813","S2823","Empty"]
[{"$nulls":3},"Geldanamycin (NSC 122750)","AG-1478 (Tyrphostin AG-1478)","PF-04691502","Tivantinib (ARQ 197)","Dinaciclib (SCH727965)","PF-5274857","A-803467","AZD4547","Ciproxifan Maleate","Tideglusib (NP031112)"]
[null,"g","Empty","S2714","S2730","S2745","S2754","S2769","S2778","S2789","S2803","S2814","S2824","Empty"]
[{"$nulls":3},"LY411575","Crenolanib (CP-868596)","CHIR-98014","Xevinapant (AT406)","Dovitinib (TKI-258) Dilactic Acid","GW842166X","Tofacitinib (CP-690550)","Galeterone","Alpelisib (BYL719)","TPCA-1"]
[null,"h","Empty","S2718","S2731","S2746","S2755","S2770","S2779","S2790","S2804","S2816","S2825","Empty"]
[{"$nulls":3},"TAK-901","AZ 3146","AZ 628","Varlitinib","MK-5108 (VX-689)","M344","Istradefylline","Sirtinol","Tyrphostin AG 879","ML133 HCl"]
[]
[]
[]
[null,"Plate layout: L3000-13"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2840","S2858","S2868","S2885","S2898","S2907","S2919","S2928","S3015","S3025","Empty"]
[{"$nulls":3},"Apalutamide (ARN-509)","StemRegenin 1 (SR1)","Alogliptin (SYR-322) benzoate","A-205804","MLN0905","Pirfenidone (S-7701)","IOX2","TAK-715","Amoxicillin","PMSF"]
[null,"b","Empty","S2842","S2859","S2871","S2890","S2899","S2910","S2921","S2929","S3017","S3026","Empty"]
[{"$nulls":3},"SAR131675","Golvatinib (E7050)","T0070907","PF-562271","GNF-2","Tempol","PF-4981517","Pifithrin-α (PFTα) HBr","Aspirin (NSC 27223)","Piceatannol"]
[null,"c","Empty","S2843","S2860","S2872","S2891","S2900","S2911","S2922","S2930","S3018","S3027","Empty"]
[{"$nulls":3},"BI-D1870","IEM 1754 2HBr","GW5074","GW441756","Cobicistat (GS-9350)","Go 6983","Icotinib (BPI-2009H)","Pifithrin-μ","Niflumic acid","Fenoprofen calcium hydrate"]
[null,"d","Empty","S2845","S2862","S2874","S2892","S2901","S2912","S2923","S3001","S3019","S3030","Empty"]
[{"$nulls":3},"Semaxanib (SU5416)","VU 0364770","Camostat Mesilate","VU 0361737","CCG 50014","WZ811","Salubrinal","Clevudine","Ciclopirox ethanolamine","Niclosamide (BAY2353)"]
[null,"e","Empty","S2851","S2863","S2875","S2894","S2902","S2913","S2924","S3002","S3021","S3032","Empty"]
[{"$nulls":3},"Baricitinib (INCB028050)","Nodinitib-1","Prucalopride","SB742457","S-Ruxolitinib (INCB018424)","BAY 11-7082","Laduviglusib (CHIR-99021) HCl","Rivaroxaban (BAY 59-7939)","Rimonabant (SR141716)","Bindarit (AF 2838)"]
[null,"f","Empty","S2852","S2864","S2882","S2895","S2904","S2914","S2925","S3005","S3022","S3035","Empty"]
[{"$nulls":3},"BRL-54443","IMD 0354","IKK-16 (IKK Inhibitor VII)","Tyrphostin 9","PF-477736","Dapivirine (TMC120)","Evacetrapib (LY2484595)","Paroxetine HCl","Cabazitaxel (XRP6258)","Daunorubicin (RP 13057) HCl"]
[null,"g","Empty","S2853","S2866","S2883","S2896","S2905","S2915","S2926","S3008","S3023","S3036","Empty"]
[{"$nulls":3},"Carfilzomib (PR-171)","U-104","4-Aminohippuric Acid","ZM 323881 HCl","JNJ-7777120","GW9662","TDZD-8","Zaltoprofen","Bufexamac","Pravastatin sodium"]
[null,"h","Empty","S2854","S2867","S2884","S2897","S2906","S2916","S2927","S3012","S3024","S3037","Empty"]
[{"$nulls":3},"BML-190","WHI-P154","Acesulfame Potassium","ZM 306416","Ki16198","ML161 (Parmodulin 2)","Apoptosis Activator 2","Pazopanib","Lamotrigine","Bepotastine Besilate"]
[]
[]
[]
[null,"Plate layout: L3000-14"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3043","S3079","S3117","S3149","S3175","S3195","S3606","S3616","S3633","S3654","Empty"]
[{"$nulls":3},"Rofecoxib","Atovaquone","Oxybutynin hydrochloride","Estradiol valerate","Atomoxetine HCl","Azlocillin sodium salt","Fangchinoline","Asiaticoside","Pyrrolidinedithiocarbamate ammonium","Tauroursodeoxycholic Acid (TUDCA)"]
[null,"b","Empty","S3046","S3080","S3120","S3151","S3176","S3196","S3608","S3621","S3639","S3655","Empty"]
[{"$nulls":3},"Azilsartan","Etravirine (TMC125)","Doxepin HCl","Gliquidone","Betahistine 2HCl","Azacyclonol","Demethylzeylasteral (T-96)","Pazufloxacin mesylate","Tacrine hydrochloride hydrate","Cefepime Dihydrochloride Monohydrate"]
[null,"c","Empty","S3047","S3081","S3124","S3160","S3178","S3200","S3609","S3622","S3641","S3656","Empty"]
[{"$nulls":3},"Otilonium Bromide","Ulipristal Acetate (CDB 2914)","Dexamethasone Acetate","Ethynodiol diacetate","Brinzolamide","Triflusal","Berbamine dihydrochloride","Diammonium Glycyrrhizinate","Osalmid","Piribedil"]
[null,"d","Empty","S3052","S3083","S3129","S3162","S3180","S3201","S3610","S3625","S3643","S3657","Empty"]
[{"$nulls":3},"Rupatadine Fumarate","Indacaterol Maleate","Trimethoprim","Tylosin tartrate","Eletriptan HBr","Trifluoperazine 2HCl","Cordycepin","Tyramine","Amitraz","Promestriene"]
[null,"e","Empty","S3054","S3100","S3132","S3167","S3181","S3212","S3611","S3626","S3647","S3658","Empty"]
[{"$nulls":3},"Alverine Citrate","2-Thiouracil","Sulfamerazine","Altrenogest","Flumequine","Moclobemide (Ro 111163)","(+)-Fangchinoline","Sesamol","Mafenide Acetate","O6-Benzylguanine"]
[null,"f","Empty","S3057","S3104","S3137","S3170","S3183","S3600","S3612","S3627","S3648","S3659","Empty"]
[{"$nulls":3},"Azilsartan Medoxomil","Moguisteine","Sodium salicylate","Ampicillin sodium","Amitriptyline HCl","Schisandrin B (Sch B)","Rosmarinic acid","Tryptamine","Amlexanox (AA-673)","Fludrocortisone acetate"]
[null,"g","Empty","S3067","S3105","S3138","S3172","S3185","S3603","S3613","S3629","S3651","S3661","Empty"]
[{"$nulls":3},"Chlorhexidine 2HCl","Nadifloxacin","Methylthiouracil","Anagrelide HCl","Adrenalone HCl","Betulinic acid","Scoparone","Syringic acid","4-Amino-5-imidazolecarboxamide","2-Methoxy-1,4-naphthoquinone"]
[null,"h","Empty","S3078","S3116","S3144","S3173","S3186","S3604","S3615","S3630","S3653","S3665","Empty"]
[{"$nulls":3},"Beclomethasone dipropionate","Sulfathiazole","Darifenacin HBr","Antipyrine","Azatadine dimaleate","Triptolide (PG490)","Dehydrocostus Lactone","Methyl Vanillate","Spermidine trihydrochloride","Trolox"]
[]
[]
[]
[null,"Plate layout: L3000-15"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3666","S3679","S3695","S3711","S3742","S3769","S3785","S3802","S3812","S3823","Empty"]
[{"$nulls":3},"Ilaprazole","Flavanone","Cystamine dihydrochloride","Carbasalate Calcium","Cholic acid","Palmatine","Notoginsenoside R1","Trigonelline Hydrochloride","Monocrotaline","Schizandrol A"]
[null,"b","Empty","S3668","S3681","S3696","S3714","S3745","S3771","S3786","S3804","S3813","S3825","Empty"]
[{"$nulls":3},"Thymopentin","Vitamin E Acetate","PTP Inhibitor I","Lifitegrast","Balsalazide disodium","Stachydrine","Glabridin","Alpha-Mangostin","Bakuchiol","Glycitin"]
[null,"c","Empty","S3669","S3683","S3697","S3720","S3751","S3774","S3787","S3805","S3814","S3826","Empty"]
[{"$nulls":3},"Carmustine","Methylmalonate","Mafenide hydrochloride","Elafibranor","Quinidine hemisulfate hydrate","Dehydroandrographolide Succinate Potasium Salt","Picroside I","Stevioside","Tubeimoside I","Hydroxytyrosol"]
[null,"d","Empty","S3671","S3684","S3698","S3724","S3757","S3776","S3788","S3807","S3815","S3829","Empty"]
[{"$nulls":3},"Quinestrol","Methacholine chloride","Nortriptyline hydrochloride","Velpatasvir","2'-Deoxyinosine","Sophoricoside","Carvacrol","Dehydroandrographolide","Mogroside V","Isoalantolactone"]
[null,"e","Empty","S3672","S3687","S3699","S3725","S3758","S3778","S3790","S3808","S3817","S3832","Empty"]
[{"$nulls":3},"Cefonicid sodium","Urea","2,3-Butanedione-2-monoxime","ELR-510444","Sinomenine hydrochloride","Patchouli alcohol","Methyl gallate","Mangiferin","Harmine hydrochloride","Euphorbiasteroid"]
[null,"f","Empty","S3675","S3690","S3701","S3731","S3759","S3779","S3792","S3809","S3818","S3833","Empty"]
[{"$nulls":3},"Umbelliferone","Pargyline hydrochloride","Benactyzine hydrochloride","Tipiracil hydrochloride","Norcantharidin","cis-Anethole","Guggulsterone E&Z","Imperatorin","Tectoridin","Amentoflavone"]
[null,"g","Empty","S3676","S3692","S3702","S3732","S3765","S3780","S3794","S3810","S3819","S3835","Empty"]
[{"$nulls":3},"Carbendazim","N-Ethylmaleimide (NEM)","Dihydrothymine","Avibactam sodium","Picroside II","Secoisolariciresinol diglucoside","Palmitic acid","Scutellarin","Decursinol angelate","Loganin"]
[null,"h","Empty","S3677","S3694","S3707","S3739","S3766","S3784","S3800","S3811","S3822","S3836","Empty"]
[{"$nulls":3},"Cinnamic acid","Glucosamine hydrochloride","Ethopabate","Calcipotriene","Tanshinone IIA sulfonate sodium","Obacunone (AI3-37934)","Lycorine hydrochloride","Ginsenoside Re","Schisandrin A","6-Gingerol"]
[]
[]
[]
[null,"Plate layout: L3000-16"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3837","S3849","S3868","S3879","S3892","S3900","S3912","S3924","S3932","S3944","Empty"]
[{"$nulls":3},"Echinocystic acid","D-Galactose","Harmine","Kaempferide","Isopsoralen","Betulonic acid","Cephalotaxine","Ginsenoside Rb1","Astilbin","Valproic acid (VPA)"]
[null,"b","Empty","S3838","S3850","S3869","S3882","S3893","S3901","S3914","S3925","S3934","S3945","Empty"]
[{"$nulls":3},"Carnosic acid","Glucosamine sulfate","Methyl protocatechuate","Brassinolide","Bornyl acetate","Astragaloside IV","α-Hederin","(-)-Epicatechin gallate","Acetyl Resveratrol","L-Cycloserine"]
[null,"c","Empty","S3840","S3851","S3870","S3883","S3894","S3902","S3915","S3926","S3935","S3951","Empty"]
[{"$nulls":3},"Baohuoside I","Camphor","D-Pinitol","Protopine","Cycloastragenol","Ursonic acid","Gracillin","Forsythin","Nonivamide","Tannic acid"]
[null,"d","Empty","S3841","S3853","S3871","S3884","S3895","S3903","S3916","S3927","S3937","S3952","Empty"]
[{"$nulls":3},"Eleutheroside B","Perillyl alcohol","Muscone","Jatrorrhizine","Sophoridine","Lycorine","Macranthoidin B","Swertiamarin","Pterostilbene","3,4-Dihydroxybenzaldehyde"]
[null,"e","Empty","S3842","S3856","S3874","S3885","S3896","S3904","S3917","S3928","S3938","S3956","Empty"]
[{"$nulls":3},"Isoquercitrin","Allantoin","Curcumenol","Pyrogallol","(1R,2R)-trans-N-Boc-1,2-cyclohexanediamine","Isoimperatorin","Tetrahydrocurcumin","Baccatin Ⅲ","Bisdemethoxycurcumin (BDMC)","Tetramethylpyrazine"]
[null,"f","Empty","S3844","S3857","S3875","S3887","S3897","S3905","S3921","S3929","S3940","S3957","Empty"]
[{"$nulls":3},"Rosavin","4-Hydroxybenzyl alcohol","Alpinetin","α-L-Rhamnose monohydrate","(-)-Arctigenin","Iso-Steviol","Lathyrol","Liquiritigenin","3'-Hydroxypterostilbene","Gamma-Oryzanol"]
[null,"g","Empty","S3846","S3860","S3876","S3888","S3898","S3908","S3922","S3930","S3941","S3959","Empty"]
[{"$nulls":3},"Eupatilin","Allicin","Indigo","3,4',5-Trimethoxy-trans-stilbene","Hydroxy Camptothecine","4'-Demethylpodophyllotoxin","(-)-epigallocatechin","Liquiritin","Pinocembrin","(+)-Borneol"]
[null,"h","Empty","S3847","S3867","S3878","S3889","S3899","S3911","S3923","S3931","S3942","S3960","Empty"]
[{"$nulls":3},"Panaxatriol","(E)-Cardamonin","Bavachinin","Arteether","Hederagenin","Veratramine","Ginsenoside Rg1","Ginsenoside Rd","Cardamonin","Higenamine hydrochloride"]
[]
[]
[]
[null,"Plate layout: L3000-17"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3966","S3982","S4003","S4017","S4034","S4047","S4071","S4081","S4098","S4116","Empty"]
[{"$nulls":3},"Nifuratel","Batyl alcohol","Lithocholic acid","Allylthiourea","Diphemanil Methylsulfate","Bisacodyl","Griseofulvin","Sulfacetamide Sodium","Halcinonide","Isovaleramide"]
[null,"b","Empty","S3967","S3983","S4004","S4018","S4037","S4049","S4072","S4082","S4101","S4118","Empty"]
[{"$nulls":3},"Flavone","Caryophyllene oxide","Ethambutol 2HCl","Sennoside B","Doxapram HCl","Valdecoxib","Decamethonium Bromide","Spiramycin","Voglibose","Histamine 2HCl"]
[null,"c","Empty","S3968","S3984","S4007","S4019","S4039","S4051","S4073","S4083","S4102","S4119","Empty"]
[{"$nulls":3},"Histamine","Nordihydroguaiaretic acid (NDGA)","Pentamidine isethionate","Avanafil","Methazolamide","Nabumetone","Sodium 4-Aminosalicylate","Vitamin A Acetate","Eprosartan Mesylate","Pefloxacin Mesylate Dihydrate"]
[null,"d","Empty","S3970","S3987","S4009","S4022","S4040","S4053","S4075","S4086","S4104","S4120","Empty"]
[{"$nulls":3},"Vindoline","L-Tryptophan","Mirabegron","Probenecid","Norethindrone","Sertraline HCl","Zinc Pyrithione","Loxapine Succinate","Diminazene Aceturate","Sulconazole Nitrate"]
[null,"e","Empty","S3974","S3988","S4010","S4023","S4041","S4054","S4076","S4088","S4107","S4123","Empty"]
[{"$nulls":3},"(+)-Catechin hydrate","Theophylline-7-acetic acid","Acebutolol HCl","Procaine HCl","Olsalazine Sodium","Spironolactone","Propranolol HCl","Flumethasone","Clofazimine","Timolol Maleate"]
[null,"f","Empty","S3975","S3996","S4011","S4024","S4042","S4059","S4078","S4089","S4110","S4124","Empty"]
[{"$nulls":3},"Protocatechuic acid","Thioctic acid","Ampiroxicam","Homatropine Methylbromide","Nafcillin Sodium","Sodium Nitroprusside Dihydrate","Mefenamic Acid","Halobetasol Propionate","Estradiol Benzoate","Tolazoline HCl"]
[null,"g","Empty","S3980","S3998","S4012","S4025","S4045","S4065","S4079","S4090","S4113","S4125","Empty"]
[{"$nulls":3},"Pyridoxine","(+)-α-Lipoic acid","Desloratadine","Homatropine Bromide","Pheniramine Maleate","Guanabenz Acetate","Ticagrelor","Fenspiride HCl","Desvenlafaxine","Sodium Phenylbutyrate"]
[null,"h","Empty","S3981","S4001","S4014","S4026","S4046","S4070","S4080","S4095","S4114","S4131","Empty"]
[{"$nulls":3},"Sinapinic Acid","Cabozantinib malate","Hyoscyamine","Hydroxyzine 2HCl","Estradiol Cypionate","Guanidine HCl","Triamterene","Difluprednate","Triclabendazole","Levodropropizine"]
[]
[]
[]
[null,"Plate layout: L3000-18"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4135","S4160","S4171","S4186","S4197","S4214","S4230","S4243","S4256","S4268","Empty"]
[{"$nulls":3},"Clorprenaline HCl","Penicillin G Sodium","Choline Chloride","Domiphen Bromide","Bemegride","Sucralose","Oxaprozin","Deoxycorticosterone acetate","Buspirone HCl","Flufenamic acid"]
[null,"b","Empty","S4136","S4162","S4172","S4187","S4201","S4216","S4231","S4244","S4257","S4269","Empty"]
[{"$nulls":3},"Carprofen","Benzethonium Chloride","Cetylpyridinium Chloride","Salicylanilide","Florfenicol","Valnemulin HCl","Pilocarpine HCl","Serotonin HCl","Alizapride HCl","Vinorelbine ditartrate (KW-2307)"]
[null,"c","Empty","S4147","S4164","S4175","S4188","S4206","S4217","S4232","S4246","S4259","S4270","Empty"]
[{"$nulls":3},"Azithromycin Dihydrate","Doxofylline","Sulfaguanidine","Sasapyrine","Cysteamine HCl","Liothyronine Sodium","Nithiamide","Tranylcypromine (2-PCPA) HCl","Vilazodone HCl","Oxiracetam"]
[null,"d","Empty","S4149","S4165","S4177","S4190","S4207","S4221","S4237","S4249","S4260","S4277","Empty"]
[{"$nulls":3},"Amfenac Sodium Monohydrate","Benzydamine HCl","Uracil","Cinchophen","Clofibric Acid","Benzbromarone","Primaquine Diphosphate","Flopropione","Tamibarotene","Bambuterol HCl"]
[null,"e","Empty","S4151","S4166","S4181","S4192","S4208","S4223","S4238","S4250","S4263","S4278","Empty"]
[{"$nulls":3},"Penfluridol","Chlorpropamide","Nicardipine HCl","Chlorquinaldol","Chromocarb","Mevastatin","Cepharanthine","Sulfamethoxypyridazine","Efaproxiral Sodium","Carteolol HCl"]
[null,"f","Empty","S4152","S4167","S4182","S4194","S4210","S4224","S4239","S4251","S4265","S4280","Empty"]
[{"$nulls":3},"Ethamsylate","Cyromazine","Nifuroxazide","Azaguanine-8","Benzocaine","Erythritol","Bergapten","Phenothiazine","Nicaraven","Meclofenoxate (Centrophenoxine) HCl"]
[null,"g","Empty","S4155","S4169","S4184","S4195","S4212","S4225","S4240","S4253","S4266","S4282","Empty"]
[{"$nulls":3},"Chlorzoxazone","Teriflunomide","Penciclovir","Broxyquinoline","Tenatoprazole","Mexiletine HCl","Doxylamine Succinate","Epinastine HCl","Brimonidine Tartrate","Nelfinavir (AG 1343) Mesylate"]
[null,"h","Empty","S4159","S4170","S4185","S4196","S4213","S4227","S4242","S4255","S4267","S4283","Empty"]
[{"$nulls":3},"Bezafibrate","Coumarin","Tiratricol","Ethacridine lactate monohydrate","Dirithromycin","Fidaxomicin","Cetrimonium Bromide (CTAB)","Quinacrine 2HCl","Diacerein","Cyclobenzaprine HCl"]
[]
[]
[]
[null,"Plate layout: L3000-19"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4285","S4299","S4334","S4353","S4381","S4406","S4509","S4527","S4546","S4570","Empty"]
[{"$nulls":3},"Ospemifene","Dicoumarol","Mesoridazine Besylate","Terfenadine","Proadifen HCl","Pindolol","4-Aminoantipyrine","Fenofibric acid","Xylitol","Halothane"]
[null,"b","Empty","S4288","S4303","S4335","S4354","S4382","S4408","S4512","S4528","S4547","S4571","Empty"]
[{"$nulls":3},"Chloroambucil","9-Aminoacridine","Metaproterenol Sulfate","Thiostrepton","Pyrilamine Maleate","Procodazole","Aceglutamide","Furazolidone","8-Hydroxyquinoline","Hexylresorcinol"]
[null,"c","Empty","S4289","S4307","S4336","S4358","S4387","S4416","S4514","S4534","S4548","S4576","Empty"]
[{"$nulls":3},"Metoclopramide HCl","Auranofin","Metaraminol Bitartrate","Pimozide","Bendroflumethiazide","Trimipramine Maleate","Acetylleucine","6-Acetamidohexanoic acid","Aminoguanidine hydrochloride","Sulfabenzamide"]
[null,"d","Empty","S4291","S4308","S4338","S4361","S4394","S4502","S4516","S4535","S4550","S4578","Empty"]
[{"$nulls":3},"Labetalol HCl","Benzthiazide","Methoxamine HCl","Cinoxacin","Clofoctol","Eltrombopag","(+)-Camphor","Methylene Blue","Azelaic acid","Tyloxapol"]
[null,"e","Empty","S4292","S4309","S4339","S4362","S4396","S4504","S4517","S4538","S4552","S4583","Empty"]
[{"$nulls":3},"Diphenidol HCl","Bromocriptine Mesylate","Meticrane","Glafenine HCl","Digoxigenin","6-Mercaptopurine (6-MP) Monohydrate","Cefotaxime sodium","Pantoprazole sodium","Bithionol","Butamben"]
[null,"f","Empty","S4294","S4316","S4342","S4367","S4398","S4505","S4521","S4539","S4561","S4585","Empty"]
[{"$nulls":3},"Procainamide HCl","Clopamide","Nialamide","Suxibuzone","Isoxicam","Vinblastine (NSC-49842) sulfate","DEET","Salicylic acid","Danthron","Succinylsulfathiazole"]
[null,"g","Empty","S4295","S4317","S4344","S4373","S4401","S4506","S4524","S4541","S4564","S4587","Empty"]
[{"$nulls":3},"Meclofenamate Sodium","Clorgyline HCl","Oxprenolol HCl","Dicyclomine HCl","Nifenazone","Acetazolamide","2-Ethoxybenzamide","Triclosan","Diethylcarbamazine citrate","Pentylenetetrazol"]
[null,"h","Empty","S4297","S4330","S4345","S4375","S4404","S4507","S4526","S4544","S4569","S4589","Empty"]
[{"$nulls":3},"Mupirocin","Isoetharine Mesylate","Pentoxifylline","Mepenzolate Bromide","Pasiniazid","17-Hydroxyprogesterone","Fenbufen","Urethane","Fluphenazine dihydrochloride","Amodiaquine dihydrochloride dihydrate"]
[]
[]
[]
[null,"Plate layout: L3000-20"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4591","S4602","S4628","S4650","S4667","S4687","S4707","S4718","S4732","S4747","Empty"]
[{"$nulls":3},"Nitroxoline","Acetohydroxamic acid","(+/-)-Sulfinpyrazone","Atipamezole","Lidocaine hydrochloride","Rivastigmine","Oleic Acid","Acetylcholine iodide","MPTP hydrochloride","Jervine"]
[null,"b","Empty","S4593","S4603","S4629","S4651","S4669","S4690","S4708","S4719","S4735","S4748","Empty"]
[{"$nulls":3},"Chlormadinone acetate","Gallic acid","Chlorotrianisene","Etoricoxib","Benzocaine hydrochloride","Escin","Palmitoylethanolamide","Kynurenic acid","Salvianolic acid B","Ondansetron Hydrochloride Dihydrate"]
[null,"c","Empty","S4594","S4604","S4630","S4656","S4672","S4693","S4709","S4722","S4736","S4749","Empty"]
[{"$nulls":3},"Cephalothin sodium","Levofloxacin hydrate","Diazoxide","Parecoxib","Dimenhydrinate","Guanfacine Hydrochloride","Latanoprost","(+)-Catechin","Trapidil","Citalopram HBr"]
[null,"d","Empty","S4595","S4609","S4633","S4658","S4673","S4695","S4711","S4723","S4737","S4750","Empty"]
[{"$nulls":3},"Cefazolin Sodium","Diflunisal","Isosorbide Mononitrate","Hydroquinidine","Etonogestrel","D panthenol","Esculetin","(-)Epicatechin","Psoralen","Sulfacetamide sodium salt hydrate"]
[null,"e","Empty","S4596","S4610","S4635","S4660","S4679","S4696","S4712","S4725","S4738","S4751","Empty"]
[{"$nulls":3},"Cefixime","Mebendazole","Cyproheptadine hydrochloride sesquihydrate","Glycopyrrolate","Terazosin HCl","CarbinoxaMine Maleate","Diethylmaleate","Benzenesulfonamide","Arctiin","Cisapride hydrate"]
[null,"f","Empty","S4599","S4619","S4641","S4662","S4682","S4697","S4714","S4727","S4743","S4753","Empty"]
[{"$nulls":3},"Benzyl benzoate","Itopride hydrochloride","Tedizolid Phosphate","Atazanavir","Loxoprofen","Saxagliptin hydrate","(-)-Menthol","Cinnarizine","Wogonin","Ganoderic acid A"]
[null,"g","Empty","S4600","S4625","S4646","S4665","S4685","S4701","S4715","S4728","S4744","S4754","Empty"]
[{"$nulls":3},"Benzyl alcohol","Alcaftadine","Ciclesonide","Rabeprazole sodium","Efavirenz","2-Deoxy-D-glucose (2-DG)","Benzamide","3,3'-Diindolylmethane","Anethole trithione","Betulin"]
[null,"h","Empty","S4601","S4627","S4647","S4666","S4686","S4706","S4717","S4731","S4746","S4758","Empty"]
[{"$nulls":3},"Clioquinol","TTNPB (Arotinoid Acid)","Cefmenoxime hydrochloride","Sivelestat sodium tetrahydrate","Vitamin E","Eugenol","Isatin","Perphenazine","(20S)-Protopanaxadiol","Crocin"]
[]
[]
[]
[null,"Plate layout: L3000-21"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4759","S4783","S4833","S4856","S4900","S4932","S4966","S4990","S5009","S5032","Empty"]
[{"$nulls":3},"p-Coumaric Acid","Benzyl isothiocyanate","Cefoxitin sodium","Iproniazid","Tenovin-6","Proxyphylline","4-Methylesculetin","TBHQ","Brivudine","Mephenesin"]
[null,"b","Empty","S4761","S4785","S4834","S4861","S4901","S4938","S4975","S4997","S5012","S5033","Empty"]
[{"$nulls":3},"Thymoquinone","Nicotinamide N-oxide","Propantheline bromide","Oxindole","JNK-IN-8","Cedrol","Fimasartan","4-Butylresorcinol","Octenidine Dihydrochloride","Terconazole"]
[null,"c","Empty","S4769","S4787","S4835","S4862","S4902","S4940","S4976","S4998","S5014","S5040","Empty"]
[{"$nulls":3},"L-5-Hydroxytryptophan","Methyl syringate","Aceclofenac","Squalene","QNZ (EVP4593)","Maltol","Sulfalene (SMPZ)","2-Aminobenzenesulfonamide","Crisaborole (AN2728)","Tiamulin"]
[null,"d","Empty","S4771","S4797","S4836","S4867","S4904","S4941","S4977","S5001","S5016","S5045","Empty"]
[{"$nulls":3},"β-thujaplicin","Nicergoline","Nilutamide","Propacetamol hydrochloride","JZL184","Farnesol","Efonidipine","Tofacitinib (CP-690550) Citrate","Isoprinosine","Nomilin"]
[null,"e","Empty","S4772","S4799","S4837","S4878","S4907","S4952","S4980","S5002","S5020","S5049","Empty"]
[{"$nulls":3},"alpha-Asarone","Indole-3-acetic acid","Ibudilast","Neticonazole Hydrochloride","SC-514","Fumaric acid","Anamorelin","Fingolimod (FTY720) HCl","Tilorone dihydrochloride","Thiocolchicoside"]
[null,"f","Empty","S4777","S4807","S4838","S4885","S4908","S4953","S4984","S5003","S5023","S5052","Empty"]
[{"$nulls":3},"Plumbagin","Uracil 1-β-D-arabinofuranoside","Acotiamide hydrochloride","Taurolidine","SN-38","Usnic acid","2,2'-Cyclouridine","Tacrolimus (FK506)","Nadolol","Granisetron"]
[null,"g","Empty","S4779","S4817","S4849","S4892","S4920","S4957","S4988","S5006","S5027","S5058","Empty"]
[{"$nulls":3},"Menadiol Diacetate","Atenolol","Levocetirizine Dihydrochloride","Phenibut","b-AP15","Linalool","Tiamulin fumarate","Teprenone","Mebeverine Hydrochloride","Revaprazan Hydrochloride"]
[null,"h","Empty","S4781","S4832","S4852","S4896","S4921","S4958","S4989","S5007","S5029","S5059","Empty"]
[{"$nulls":3},"Xanthoxyline","Tolmetin","Gadopentetate Dimeglumine","Elagolix Sodium","MNS (3,4-Methylenedioxy-β-nitrostyrene)","Glycocholic acid","AOA hemihydrochloride","Delamanid","Etofylline","Pixantrone Maleate"]
[]
[]
[]
[null,"Plate layout: L3000-22"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5060","S5083","S5130","S5153","S5202","S5241","S5265","S5285","S5304","S5316","Empty"]
[{"$nulls":3},"Metadoxine","Lentinan","Taurocholic acid sodium salt hydrate","Tetrahydroberberine","Quinocetone","Lapatinib ditosylate monohydrate","TBB","RU58841","2-Acetylphenothiazine (ML171)","NU2058"]
[null,"b","Empty","S5062","S5089","S5133","S5158","S5205","S5242","S5269","S5286","S5306","S5317","Empty"]
[{"$nulls":3},"Daclatasvir Dihydrochloride","4-Isopropylbenzaldehyde","Sodium erythorbate","alpha-Naphthoflavone","Nilotinib hydrochloride","Cediranib Maleate","J147","Ramatroban","Forchlorfenuron (CPPU)","UK 5099"]
[null,"c","Empty","S5067","S5091","S5138","S5159","S5209","S5243","S5271","S5288","S5308","S5318","Empty"]
[{"$nulls":3},"Losartan","Geranyl acetate","Citral","Doxycycline","Enoxacin Sesquihydrate","Ruxolitinib Phosphate","Suloctidil","Estropipate","7-(Diethylamino)coumarin-3-carboxylic acid","Acacetin"]
[null,"d","Empty","S5069","S5104","S5139","S5163","S5210","S5247","S5273","S5293","S5310","S5319","Empty"]
[{"$nulls":3},"Dabrafenib Mesylate","Tea polyphenol","Methyl Dihydrojasmonate","7-Methoxycoumarin","Sulfamethazine Sodium Salt","Selamectin","Canrenone","Nimustine Hydrochloride","4,4'-Dimethoxybenzil","Imepitoin"]
[null,"e","Empty","S5074","S5111","S5141","S5169","S5211","S5253","S5278","S5297","S5312","S5321","Empty"]
[{"$nulls":3},"Argatroban Monohydrate","7-Ethylcamptothecin","Pyrithioxin","2,6-Dihydroxyanthraquinone","4-Aminosalicylic acid","Cisapride (R 51619)","Tedizolid (TR-700)","Vidarabine monohydrate","Urolithin A","Y15"]
[null,"f","Empty","S5077","S5113","S5144","S5171","S5233","S5254","S5279","S5298","S5313","S5325","Empty"]
[{"$nulls":3},"Regorafenib (BAY-734506) Monohydrate","Propyl gallate","Neferine","Atrazine","Fenretinide (NSC 374551)","Dasatinib hydrochloride","Fendiline hydrochloride","Amoxicillin trihydrate","SC66","Nitisinone"]
[null,"g","Empty","S5078","S5120","S5145","S5177","S5234","S5256","S5281","S5301","S5314","S5327","Empty"]
[{"$nulls":3},"Osimertinib mesylate","Elemicin","Protoporphyrin IX","Naproxen","Nintedanib Ethanesulfonate Salt","Benproperine phosphate","Dapiprazole Hydrochloride","Carglumic Acid","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","Meisoindigo"]
[null,"h","Empty","S5082","S5122","S5151","S5200","S5240","S5262","S5284","S5303","S5315","S5341","Empty"]
[{"$nulls":3},"Vitamin K2","Abietic Acid","Gypenoside","Diaveridine","Lenvatinib (E7080) Mesylate","UNC-926","Adenosine 5'-monophosphate monohydrate","Afalanine (N-Acetyl-DL-phenylalanine)","PRT4165","Metroprolol succinate"]
[]
[]
[]
[null,"Plate layout: L3000-23"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5345","S5371","S5399","S5435","S5458","S5476","S5490","S5507","S5548","S5564","Empty"]
[{"$nulls":3},"(+/-)-nerolidol","Ajmaline","Chlorprothixene hydrochloride","Quinacrine Dihydrochloride Dihydrate","Verbascoside","Rolapitant","Disopyramide","Trimebutine maleate","7-Hydroxy-4-chromone","Xylazine"]
[null,"b","Empty","S5353","S5372","S5401","S5447","S5459","S5479","S5491","S5527","S5550","S5566","Empty"]
[{"$nulls":3},"Cefpiramide sodium","Methyl Aminolevulinate Hydrochloride","Tegaserod Maleate","Triprolidine Hydrochloride","Aucubin","Cloperastine hydrochloride","Lomefloxacin","Salmeterol","Ethyl gallate","Dapagliflozin propanediol monohydrate"]
[null,"c","Empty","S5358","S5373","S5416","S5451","S5463","S5480","S5492","S5529","S5551","S5573","Empty"]
[{"$nulls":3},"Regadenoson","Pseudolaric Acid B","Metyrapone","Ferulic acid methyl ester","Curcurbitacin IIA","Clidinium Bromide","Econazole","Galangin","6-Paradol","Tilmicosin phosphate"]
[null,"d","Empty","S5364","S5377","S5418","S5452","S5464","S5481","S5493","S5535","S5552","S5579","Empty"]
[{"$nulls":3},"DY131","Dibutyl phthalate","Parecoxib Sodium","Sanguinarine chloride","Psoralidin","Molindone hydrochloride","Atropine sulfate","Moxifloxacin","Amenamevir","Chelidonic acid"]
[null,"e","Empty","S5365","S5387","S5419","S5453","S5466","S5485","S5494","S5537","S5554","S5582","Empty"]
[{"$nulls":3},"Alogliptin","D-Tagatose","1,4-Cineole","Hyperoside","Saikosaponin A","Desipramine Hydrochloride","Salbutamol","Tizanidine","Lanatoside C","Cytarabine hydrochloride"]
[null,"f","Empty","S5366","S5392","S5424","S5454","S5469","S5486","S5498","S5538","S5556","S5586","Empty"]
[{"$nulls":3},"Fipronil","Mepivacaine","Carbaryl","Saikosaponin D","Bavachin","Fluorometholone","Betahistine mesylate","Tropisetron","(-)-Sparteine Sulfate","3-Hydroxycinnamic acid"]
[null,"g","Empty","S5369","S5394","S5426","S5456","S5471","S5487","S5502","S5542","S5561","S5592","Empty"]
[{"$nulls":3},"Ethoxyquin","Tizoxanide","Bromopyruvic acid","Isobavachalcone","Monotropein","Cefoperazone sodium","Ilaprazole sodium","7-Nitroindazole","Ethacrynic Acid","Vitamin A"]
[null,"h","Empty","S5370","S5398","S5428","S5457","S5472","S5488","S5504","S5544","S5563","S5600","Empty"]
[{"$nulls":3},"10-Hydroxydecanoic acid","Nefazodone hydrochloride","Promazine hydrochloride","Curculigoside","Nafronyl oxalate salt","Fluorescein","Ropivacaine","D-Ribose","Thioridazine hydrochloride","Flavokawain A"]
[]
[]
[]
[null,"Plate layout: L3000-24"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5602","S5649","S5663","S5684","S5711","S5728","S5754","S5781","S5800","S5815","Empty"]
[{"$nulls":3},"Gallocyanine","Hydroxyzine pamoate","Minaprine dihydrochloride","Lapachol","Deracoxib","Delapril Hydrochloride","Baricitinib phosphate","Raloxifene","Alda 1","WAY-316606"]
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[{"$nulls":3},"Tos-Arg-OMe HCl","Dexrazoxane","Orphenadrine Hydrochloride","Tryptanthrin","Pravastatin","Fosfosal","Citric acid","Dronedarone","Alprenolol hydrochloride","GSK0660"]
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[{"$nulls":3},"Sulfamide","Indacaterol","Drofenine Hydrochloride","JNJ0966","lurasidone","Stearic acid","YM 90709","Cyclic Pifithrin-α hydrobromide","Cilostamide","acalisib (GS-9820)"]
[null,"d","Empty","S5609","S5656","S5666","S5698","S5715","S5735","S5767","S5792","S5807","S5821","Empty"]
[{"$nulls":3},"Chicago Sky Blue 6B","Diphenylpyraline hydrochloride","Moxisylyte hydrochloride","Ketorolac tromethamine salt","Atorvastatin","Midodrine","Aliskiren","CID 2011756","HMN-176","Linoleic acid"]
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[{"$nulls":3},"Bedaquiline","Ertapenem sodium","Fruquintinib (HMPL-013)","Carvedilol Phosphate","Abemaciclib (LY2835219)","Diclofenac Epolamine","Sulforaphane","Motesanib (AMG-706)","Relugolix","IBMX"]
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[{"$nulls":3},"Ammonium lactate","Omeprazole Sodium","Isoxsuprine hydrochloride","Raceanisodamine","Acetohexamide","Palonosetron","AS-8351","Glycochenodeoxycholic acid","Kevetrin hydrochloride","L-Kynurenine"]
[null,"g","Empty","S5627","S5659","S5670","S5709","S5725","S5749","S5775","S5795","S5812","S5840","Empty"]
[{"$nulls":3},"Amsacrine hydrochloride","Emedastine","Chloropyramine hydrochloride","Norgestrel","Pempidine","Chlorpromazine","SR1078","Rasagiline","Choline Fenofibrate","Palifosfamide"]
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[{"$nulls":3},"Ethyl caffeate","Ranitidine","Isoproterenol sulfate dihydrate","Ambroxol","Tetryzoline","Setipiprant (ACT-129968)","Prazosin","Vanoxerine dihydrochloride","cariporide","DKM 2-93"]
[]
[]
[]
[null,"Plate layout: L3000-25"]
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[{"$nulls":3},"Chalcone","Hodostin","CAY10602","K 858","Quinoline-4-carboxylic acid","Allyl Methyl Sulfide","Salicylamide","GK921","Glycyrrhetinic acid","Genz-123346 free base"]
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[{"$nulls":3},"4'-Methoxychalcone","Canagliflozin hemihydrate","KHS101 hydrochloride","Bendamustine (SDX105)","Pyridoxal 5′-phosphate hydrate","Picolinic acid (PCL 016)","Tulobuterol hydrochloride","AGI 1067","Flurbiprofen Axetil","SMI-16a"]
[null,"c","Empty","S5863","S5903","S5920","S5950","S6118","S6288","S6409","S6424","S6459","S6498","Empty"]
[{"$nulls":3},"Metronidazole Benzoate","JANEX-1","CA-5f","Fingolimod","Terpinen-4-ol","Chlorhexidine diacetate","Zucapsaicin","TAS-301","Nifurtimox","T56-LIMKi"]
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[{"$nulls":3},"DL-Menthol","Suberohydroxamic acid","Proguanil","Ataluren (PTC124)","Cyclohexanecarboxamide","2-Methoxybenzoic acid","Clemizole","AZ876","Lucanthone","PF-6260933"]
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[{"$nulls":3},"Trans-Tranilast","Cambinol","Zerumbone","VX-702","Ureidopropionic acid","3-(Methylthio)propionic acid","Nimorazole","Ufiprazole","Eicosapentaenoic Acid","KX1-004"]
[null,"f","Empty","S5872","S5915","S5929","S6058","S6147","S6355","S6412","S6441","S6484","S6501","Empty"]
[{"$nulls":3},"Estradiol dipropionate","OAC2","4-Octyl Itaconate","β-Caryophyllene","Hexadecanedioic acid","Glycochenodeoxycholic acid sodium salt","Altiratinib","Riboflavin Tetrabutyrate","uridine triacetate","NVP 231"]
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[{"$nulls":3},"Scopolamine HBr trihydrate","GSK 5959","PNU 282987 HCl","Doxycycline monohydrate","N-(5-Aminopentyl)acetamide","Glucosamine","fexaramine","Bicyclol","CCCP","X-376"]
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[{"$nulls":3},"Rabeprazole Related Compound E","Solcitinib","BQCA","Diclofenac acid","Sudan I","2-Aminoethanethiol","Apilimod (STA-5326)","Clebopride malate","6-Bromo-2-hydroxy-3-methoxybenzaldehyde","Compound 401"]
[]
[]
[]
[null,"Plate layout: L3000-26"]
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[{"$nulls":3},"Mitapivat","WHI-P258","Briciclib","AZD2098","C-176","AP26113-analog (ALK-IN-1)","Birinapant (TL32711)","GSK2656157","Oprozomib (ONX 0912)","Tepotinib (EMD 1214063)"]
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[{"$nulls":3},"AG 494","ST 271","TTP 22","4-IBP","Longdaysin","AZD2932","VS-5584 (SB2343)","XL019","AZ20","GSK J4 HCl (GSKJ4 HCl)"]
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[{"$nulls":3},"RIPA-56","RG14620","CVT-313","JK184","Methylprednisolone hemisuccinate","BAY-61-3606","CZC24832","Wnt-C59 (C59)","CGI1746","(+)-Bicuculline"]
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[{"$nulls":3},"HG-14-10-04","NSC 42834","B-Raf IN 1","NSC23005 Sodium","Hydrocortisone butyrate","Binimetinib (MEK162)","Stattic","Epoxomicin (BU-4061T)","LY2874455","T0901317"]
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[{"$nulls":3},"GNE-477","AG 555","MTX-211","Src Inhibitor 1","(±)-Equol","PP2","Embelin","PD168393","Tezacaftor (VX-661)","Cilengitide trifluoroacetate"]
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[{"$nulls":3},"Desmethylanethol trithione","Kobe2602","ZD-4190","VUF10460","AR7","LCL161","Duvelisib (IPI-145)","AZD3514","PP1","SGC 0946"]
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[{"$nulls":3},"R112","NIH-12848","SR-3029","BQR695","GSK2981278","GDC-0152","AZD2461","CX-6258 HCl","LY2090314","RN486"]
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[{"$nulls":3},"WHI-P180","kb-NB77-78","URB602","MD2-IN-1","Fursultiamine","Merestinib (LY2801653)","RG-7112","Brefeldin A","MK-8745","Ceritinib (LDK378)"]
[]
[]
[]
[null,"Plate layout: L3000-27"]
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[{"$nulls":3},"IWR-1-endo","KY02111","(+)-JQ1","SC144","IU1","LGK-974","10058-F4","UNC1999","Siponimod (BAF312)","BIO"]
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[{"$nulls":3},"GSK2334470","HSP990 (NVP-HSP990)","IDO-IN-2","KPT-185","LDN-57444","BMS-911543","Batimastat (BB-94)","SSR128129E","JTE 013","DBeQ"]
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[{"$nulls":3},"UNC1215","PD123319","Zebularine (NSC 309132)","Marinopyrrole A (Maritoclax)","CGK 733","AZD1080","Marimastat (BB-2516)","Crenigacestat (LY3039478)","AGI-5198","Idasanutlin (RG-7388)"]
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[{"$nulls":3},"GSK923295","(-)-Blebbistatin","NU6027","TIC10 Analogue","GLPG0634 analogue","DMH1","Ilomastat","Avutometinib","CID755673","CNX-2006"]
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[{"$nulls":3},"Zotarolimus (ABT-578)","Berzosertib (VE-822)","AMG-517","PYR-41","BMS-833923","LDN-212854","Abemaciclib mesylate (LY2835219)","Spebrutinib (CC-292)","Molibresib (I-BET-762)","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)"]
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[{"$nulls":3},"SANT-1","Taselisib (GDC 0032)","Go6976","PR-619","CFTRinh-172","ML347","Glasdegib (PF-04449913)","Opaganib (ABC294640)","1-Azakenpaullone","Bisindolylmaleimide I (GF109203X)"]
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[{"$nulls":3},"IPA-3","AZD1208","Tovorafenib (MLN2480)","P5091 (P005091)","TCID","NSC 319726","Motolimod (VTX-2337)","SKI II","Olverembatinib dimesylate (HQP1351)","GSK650394"]
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[{"$nulls":3},"PF-3758309","AZD3463","XL888","P22077","NSC697923","C646","Mdivi-1","PF-543 hydrochloride","RKI-1447","PF-04418948"]
[]
[]
[]
[null,"Plate layout: L3000-28"]
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[{"$nulls":3},"Thiamet G","UNC0642","Ferrostatin-1 (Fer-1)","SKLB1002","SRPIN340","Rociletinib (CO-1686)","ML324","MS436","WZ4003","6H05"]
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[{"$nulls":3},"Skepinone-L","GSK2801","Ro3280","FLLL32","FRAX597","NMS-873","Osimertinib (AZD9291)","GSK2606414","HTH-01-015","K-Ras(G12C) inhibitor 12"]
[null,"c","Empty","S7215","S7233","S7251","S7261","S7273","S7289","S7298","S7309","S7319","S7332","Empty"]
[{"$nulls":3},"Losmapimod (GW856553X)","Bromosporine","KPT-276","Beta-Lapachone","SC75741","PFK15","AZ5104","BAY 87-2243","EHop-016","K-Ras(G12C) inhibitor 9"]
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[{"$nulls":3},"OAC1","IOX1","Selinexor (KPT-330)","Vidofludimus","SGI-1027","TAK-632","PJ34 HCl","SF1670","TG003","K-Ras(G12C) inhibitor 6"]
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[{"$nulls":3},"Alvelestat (AZD9668)","OG-L002","AZD2858","AZD1981","HPOB","RG2833 (RGFP109)","IWP-L6","Q-VD-Oph","TMP269","ERK5-IN-1"]
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[{"$nulls":3},"RepSox (E-616452)","NVP-TNKS656","Onvansertib (NMS-P937)","MM-102","Edoxaban tosylate Monohydrate","ZCL278","TEPP-46 (ML265)","Z-DEVD-FMK","Tasisulam","CW069"]
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[{"$nulls":3},"Deltarasin","G007-LK","SGC-CBP30","Golgicide A","JIB-04","PFI-2 HCl","Rilpivirine","PFI-3","ID-8","SH-4-54"]
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[{"$nulls":3},"RGFP966","AGI-6780","CNX-774","PD173955","NMS-E973","Apabetalone (RVX-208)","CPI-203","STF-118804","IOWH032","AZ191"]
[]
[]
[]
[null,"Plate layout: L3000-29"]
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[{"$nulls":3},"AZD3965","PF-562271 HCl","PTC-209","MG-101 (ALLN)","Caffeic Acid Phenethyl Ester","TAPI-1","AP-III-a4 (ENOblock)","VER-50589","Nexturastat A","Uprosertib (GSK2141795)"]
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[{"$nulls":3},"CH5138303","Poziotinib (HM781-36B)","UNC669","Z-FA-FMK","Puromycin (CL13900) 2HCl","AR-A014418","Pyridostatin (RR82) Trifluoroacetate Salt","BTB06584","MG149","INH1"]
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[{"$nulls":3},"URMC-099","K02288","AEBSF HCl","Loxistatin Acid (E-64C)","CA-074 methyl ester (CA-074 Me)","NH125","APX-3330","LDC000067","EHT 1864 2HCl","INH6"]
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[{"$nulls":3},"JSH-23","Birabresib (OTX015)","E-64","Aloxistatin (E64d)","CGP 57380","Sal003","ZLN005","PI-1840","DMOG","TAI-1"]
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[{"$nulls":3},"Bay 11-7085","GNE-0877","Leupeptin Hemisulfate","Calpeptin","KN-62","ME0328","CRT0044876","FTI 277 HCl","FH535","CK-636"]
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[{"$nulls":3},"EPZ004777","GNE-9605","Pepstatin A","Sorafenib (BAY 43-9006)","PD 151746","Ribociclib (LEE011)","FPH1 (BRD-6125)","GGTI 298 TFA salt","MPI-0479605","DDR1-IN-1"]
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[{"$nulls":3},"ARQ 621","4EGI-1","Phosphoramidon Disodium Salt","FLI-06","MI-2 (MALT1 inhibitor)","WS3","FPH2 (BRD-9424)","LB42708","YH239-EE","ESI-09"]
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[{"$nulls":3},"HS-173","4E1RCat","(-)-p-Bromotetramisole Oxalate","Anisomycin","SB-3CT","WS6","VER-49009","Triapine","WIKI4","HJC0350"]
[]
[]
[]
[null,"Plate layout: L3000-30"]
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[{"$nulls":3},"HO-3867","GNF-5837","ML323","Pritelivir (BAY 57-1293)","AT13148","GSK-LSD1 2HCl","Epacadostat (INCB024360) analogue","RBC8","GSK1324726A (I-BET726)","Cerdulatinib (PRT062070) hydrochloride"]
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[{"$nulls":3},"(S)-crizotinib","Darapladib (SB-480848)","Vactosertib (TEW-7197)","THZ1 2HCl","SAR125844","LLY-507","Reversine","BQU57","PI-3065","SU9516"]
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[{"$nulls":3},"JNK Inhibitor IX","Afuresertib (GSK2110183)","UMI-77","Piperlongumine","WH-4-023","UNC2025 HCl","BRD4770","EI1","SD-208","DTP3"]
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[{"$nulls":3},"ML167","Entospletinib (GS-9973)","Lorlatinib (PF-6463922)","CFI-400945","IM-12","AGK2","Splitomicin","PX-478 2HCl","Niraparib (MK-4827) tosylate","LDC1267"]
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[{"$nulls":3},"LY2857785","FR 180204","PTC-209 HBr","GDC-0623","LMK-235","Ledipasvir (GS5885)","Santacruzamate A (CAY10683)","CPI-169","LDN-214117","3PO"]
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[{"$nulls":3},"VGX-1027","XMD8-92","SB273005","Domatinostat (4SC-202)","UNC0379","GSK J1","CAY10603","Tasquinimod","TH287","Remodelin hydrobromide"]
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[{"$nulls":3},"Y-320","GNF-5","Decernotinib (VX-509)","CL-387785 (EKI-785)","A-366","Anacardic Acid","BV-6","MI-2 (Menin-MLL Inhibitor)","TH588","D 4476"]
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[{"$nulls":3},"AZD7545","GNE-7915","G-749","Darolutamide (ODM-201)","GSK2830371","LRRK2-IN-1","Filgotinib (GLPG0634)","MI-3 (Menin-MLL Inhibitor)","Lomitapide Mesylate","PF-431396"]
[]
[]
[]
[null,"Plate layout: L3000-31"]
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[{"$nulls":3},"Pilaralisib (XL147)","Telaglenastat (CB-839)","Picropodophyllin (PPP)","SP2509","Ceralasertib (AZD6738)","BMH-21","BRD73954","SCR7","BPTES","STF-083010"]
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[{"$nulls":3},"Voxtalisib (XL765)","CPI-360","NPS-1034","OF-1","AZD8186","CCG-1423","NU1025","CCT196969","Gilteritinib (ASP2215)","Elacridar (GF120918)"]
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[{"$nulls":3},"OTS964","Kartogenin","Omaveloxolone (RTA-408)","PIK-III","LY2409881","SBE 13 HCl","AZD3839","ANA-12","6-Thio-dG","SU6656"]
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[{"$nulls":3},"MI-773 (SAR405838)","Obeticholic Acid","L-685,458","Salirasib","LY2584702 Tosylate","Monomethyl auristatin E (MMAE)","ISO-1","Ro-3306","TRx0237 (LMTX) mesylate","Emricasan (IDN-6556)"]
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[{"$nulls":3},"Peficitinib (ASP015K)","Ruboxistaurin (LY333531) HCl","Savolitinib (AZD6094)","SecinH3","Verdinexor (KPT-335)","Bikinin","LFM-A13","EPZ015666 (GSK3235025)","D-Luciferin","Akti-1/2"]
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[{"$nulls":3},"PND-1186 (VS-4718)","SU5402","YK-4-279","PS-1145","FIIN-2","BLZ945","SB239063","Pluripotin (SC1)","BP-1-102","Dasatinib Monohydrate"]
[]
[]
[]
[null,"Plate layout: L3000-32"]
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[{"$nulls":3},"Erlotinib (OSI-774)","GSK503","MI-136","SGC707","SGI-7079","SC79","SBI-0206965","SW033291","Kenpaullone","BEC HCl"]
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[{"$nulls":3},"Docetaxel Trihydrate","FRAX486","MI-463","OICR-9429","BDA-366","Oltipraz","Onatasertib (CC 223)","PFI-4","Bromodeoxyuridine (BrdU)","STF-31"]
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[{"$nulls":3},"GNE-317","AMG319","Licochalcone A","Cyclo(RGDyK)","8-Bromo-cAMP","ONO-4059 analogue","Sodium Tauroursodeoxycholate (TUDC)","MCB-613","WZB117","Nemiralisib"]
[]
[]
[]
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[{"$nulls":3},"NSC12","Ozanimod (RPC1063)","PLX7904","FG-2216","Ricolinostat (ACY-1215)","GW9508","GSK3787","Zelavespib (PU-H71)","ETP-46464","Vorapaxar (MK-5348)"]
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[{"$nulls":3},"NCT-501","ETC-1002","PLX8394","VPS34-IN1","GSK2636771","Agerafenib (RXDX-105)","Tariquidar (XR9576)","GDC-0349","Macitentan (ACT 064992)","Chaetocin"]
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[{"$nulls":3},"Bioymifi","CP21R7 (CP21)","AZD8835","A-196","PQ 401","Vonoprazan Fumarate (TAK-438)","NSC 23766","Cobimetinib (GDC-0973)","ASP3026","UNC0638"]
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[{"$nulls":3},"O4I1","EPI-001","P7C3","LDC4297 (LDC044297)","ZM 39923 HCl","Nirogacestat (PF-03084014)","PRT062607 (P505-15) HCl","GW2580","Lomeguatrib","NSC 405020"]
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[{"$nulls":3},"O4I2","Lificiguat (YC-1)","Zorifertinib (AZD3759)","SKF38393 HCl","SMI-4a","Capivasertib (AZD5363)","Apremilast (CC-10004)","Scriptaid","Pacritinib (SB1518)","Optovin"]
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[{"$nulls":3},"KC7F2","SIS3 HCl","L755507","Entrectinib (RXDX-101)","BIX 01294","GW0742","Butein","BMS-345541","Riviciclib hydrochloride (P276-00)","PluriSIn #1 (NSC 14613)"]
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[{"$nulls":3},"PX-12","Larotrectinib (LOXO-101) sulfate","Favipiravir (T-705)","SKF96365","VE-821","TCS 359","Necrostatin-1","Venetoclax (ABT-199)","Sabutoclax","RI-1"]
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[{"$nulls":3},"Ochromycinone (STA-21)","TIC10 (ONC201)","Napabucasin (BBI608)","Tenovin-1","AG-18","Tyrphostin AG 1296","UPF 1069","Tubastatin A","Nutlin-3b","Bardoxolone Methyl"]
[]
[]
[]
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[{"$nulls":3},"Tubercidin","NSC59984","Resiquimod (R-848)","PD0166285","tirabrutinib(ONO-4059) hydrochloride","SBI-0640756","ML264","PF-8380","Ponesimod","Necrosulfonamide"]
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[{"$nulls":3},"Mirin","GSK591","Radotinib","NSC348884","AMG 337","NSC87877","MK-4101","Bitopertin","EAI045","CCT245737"]
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[{"$nulls":3},"C-DIM12","MS023","Riociguat (BAY 63-2521)","RSL3","Daprodustat (GSK1278863)","Pimavanserin tartrate","BI-78D3","NT157","Etomoxir sodium salt","GSK583"]
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[{"$nulls":3},"K03861","Acalabrutinib (ACP-196)","Sivelestat (ONO-5046)","ARS-853 (ARS853)","Ro 61-8048","BFH772","PF-06447475","RS-1","Thiomyristoyl","GSK6853"]
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[{"$nulls":3},"Z-VAD(OH)-FMK (Caspase Inhibitor VI)","RHPS 4 methosulfate","GNF-7","ON123300","BH3I-1","CPI-637","Ivosidenib (AG-120)","IC261","IQ-1","XMD8-87"]
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[{"$nulls":3},"SCH58261","Pamapimod","Cl-amidine","Paxalisib (GDC-0084)","BI-7273","SUN11602","HLCL-61 HCL","SB366791","HPI-4 (Ciliobrevin A)","XMD16-5"]
[]
[]
[]
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[{"$nulls":3},"Tomivosertib (eFT-508)","MKC-3946","CZ415","NSC228155","ZK756326 2HCl","Miransertib (ARQ 092) HCl","NMS-P118","ML390","MX69","PNU-74654"]
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[{"$nulls":3},"FCCP","CPI-455 HCl","HA15","5-Iodotubercidin","Saccharin 1-methylimidazole (SMI)","SGC2085","Apoptozole","MSC2530818","S49076","Troglitazone (CS-045)"]
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[{"$nulls":3},"SHP099 HCl","VLX1570","Ossirene","3BDO","KYA1797K","PT2385","CRT0066101 dihydrochloride","ML-7 HCl","RRx-001","NS-398 (NS398)"]
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[{"$nulls":3},"(±)-Shikonin","NQDI-1","SR-12813","Alantolactone","CeMMEC13","Lirametostat (CPI-1205)","LM10","LXR-623 (WAY-252623)","Naquotinib(ASP8273)","B02"]
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[{"$nulls":3},"IMR-1","Atractylenolide I","Kobe0065","7,8-Dihydroxyflavone","Eganelisib (IPI-549)","APS-2-79 HCl","Lys05","Eltanexor (KPT-8602)","Stenoparib (E7449)","T-3775440 HCl"]
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[{"$nulls":3},"CCF642","Selonsertib (GS-4997)","TRC051384","SKL2001","XMU-MP-1","WNK463","BGP-15 2HCl","Mivebresib (ABBV-075)","R-IMPP","Monastrol"]
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[{"$nulls":3},"SQ22536","Olmutinib (BI 1482694)","Leukadherin-1","Samotolisib (LY3023414)","PF-06409577","UNC3866","AZD9496","Erdafitinib (JNJ-42756493)","10074-G5","LW 6"]
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[]
[]
[]
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[{"$nulls":3},"Importazole","LF3","EED226","Temuterkib (LY3214996)","Verubecestat (MK-8931)","COTI-2","Autophinib","α-cyano-4-hydroxycinnamic acid(α-CHCA)","Diphenyleneiodonium chloride (DPI)","Skp2 inhibitor C1 (SKPin C1)"]
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[{"$nulls":3},"BAY-876","SRT3025 HCl","Fisogatinib (BLU-554)","Asciminib (ABL001)","RXDX-106 (CEP-40783)","Repotrectinib (TPX-0005)","S 38093","PKM2 inhibitor(compound 3k)","Necrostatin 2 racemate (Nec-1s)","PF-06840003"]
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[{"$nulls":3},"TAK-063","CBL0137 HCl","Belizatinib (TSR-011)","AZ31","Amcasertib (BBI503)","ACSS2 inhibitor","C188-9","NCT-503","GNF-6231","GI254023X"]
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[{"$nulls":3},"Salermide","GSK180736A (GSK180736)","AD80","IDO inhibitor 1","Sitravatinib (MGCD516)","SF2523","JQ-EZ-05 (JQEZ5)","OSS_128167","IWP-O1","CA3 (CIL56)"]
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[{"$nulls":3},"Citarinostat (ACY-241)","PD-166866 (PD166866)","Senexin A","Tofogliflozin(CSG 452)","A2AR antagonist 1","FX1","Adenosine Dialdehyde (ADOX)","3-TYP","iCRT3","PTC-028"]
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[{"$nulls":3},"GSK'872 (GSK2399872A)","PF-06726304","GSK2256098","HJC0152","EAD1","Pamiparib (BGB-290)","Derazantinib(ARQ-087)","Linrodostat (BMS-986205)","ACY-738","Takinib (EDHS-206)"]
[]
[]
[]
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[{"$nulls":3},"Elimusertib (BAY-1895344) hydrochloride","PHTPP","iCRT14","Atuveciclib (BAY-1143572)","Avitinib (AC0010)","INCB054329","dBET6","WM-1119","Zanubrutinib (BGB-3111)","LIT-927"]
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[{"$nulls":3},"Tenalisib (RP6530)","Abequolixron (RGX-104)","UM-164","PK11000","SKLB-23bb","Alofanib (RPT835)","IITZ-01","Evobrutinib (M-2951)","ULK-101","Almonertinib (HS-10296)"]
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[{"$nulls":3},"ONC212","RAF709","Nemtabrutinib (ARQ 531)","AZ32","PHY34","AZ304","Tinostamustine(EDO-S101)","UPGL00004","FDL169","V-9302"]
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[{"$nulls":3},"Glumetinib (SCC244)","CID16020046","PDGFR inhibitor 1","BI-3812","H3B-5942","Ripretinib (DCC-2618)","IDF-11774","GSK'547","MK-3903","SEL120 (SEL120-34A) hydrochloride"]
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[{"$nulls":3},"Cu-CPT22","2-D08","ABBV-744","Verinurad (RDEA3170)","BAY-8002","S55746","LY 3200882","CH7057288","PFK158","BAY-218"]
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[{"$nulls":3},"AZD1390","SNS-314 Mesylate","A-804598","Bimiralisib (PQR309)","MBQ-167","Iberdomide (CC220)","TH34","SSE15206","DC661","compound 3i (666-15)"]
[]
[]
[]
[null,"Plate layout: L3000-38"]
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[{"$nulls":3},"BMS-1166","(20R)Ginsenoside Rg3","Corosolic acid","Gallocatechin gallate","Mulberroside A","Corilagin","Eleutheroside E","Tectorigenin","Erianin","Rubimaillin"]
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[{"$nulls":3},"ZT-12-037-01","20S-Ginsenoside Rg3","Wedelolactone","Hydroxy safflor yellow A","Epigoitrin","10-Gingerol","Glycitein","Apigetrin","Pulegone","Rhapontigenin"]
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[{"$nulls":3},"Bentamapimod (AS602801)","20S-Ginsenoside Rh2","6-Shogaol","Harringtonine","Anhydroicaritin","Nardosinone","Timosaponin A3","Schizandrol B","Berbamine","Curdione"]
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[{"$nulls":3},"GSK8612","Gambogenic acid","Berberine","Songorine","Manninotriose","Pogostone","Kaempferitrin","Carnosol","Peiminine","Griffonilide"]
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[{"$nulls":3},"2'-deoxyguanosine","Sanguinarine","Leonurine Hydrochloride","Specnuezhenide","Rhapontin","Senegenin","Ononin","Harpagide","Daurisoline","Columbin"]
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[{"$nulls":3},"Columbianadin","Calycosin","Auraptene","Sweroside","Corynoline","Fraxinellone","Wogonoside","Artemisic acid","Chelidonine","Tussilagone"]
[]
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[]
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[]
[]
[]
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[{"$nulls":3},"8-Gingerol","Madecassic acid","AM580","NG 52","Methylprednisolone sodium succinate","MSX-122","Belotecan (CKD-602) hydrochloride","IQ-1S","SR1001","C7280948"]
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[]
[]
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[{"$nulls":3},"Etofenamate","Y16","Unesbulin (PTC596)","BAI1","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)","Vitexin","Fadrozole (CGS16949A)","SKLB4771 (FLT3-IN-1)","AIM-100","NKL 22"]
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[{"$nulls":3},"Inauhzin","I-CBP112","Gboxin","NG25","Boldine","Dehydroandrographolide Succinate","Lasofoxifene Tartrate","CZC-25146","BIBF-0775","Bardoxolone"]
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[]
[]
[]
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[{"$nulls":3},"STING inhibitor C-178","ODM-203","Solasonine","ML216","Seclidemstat (SP-2577)","BCI-121","PQR620","C75 trans","HLM006474","SC-43"]
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[{"$nulls":3},"L-779450","Ginsenoside F2","L 189","Triglycidyl Isocyanurate (Teroxirone)","DIM-C-pPhOH","Ki20227","MZ-1","BAY-1816032","JMS-17-2","6-Methoxydihydrosanguinarine"]
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[{"$nulls":3},"Merimepodib","Chikusetsusaponin IVa","ML327","Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)","Tyrphostin AG-528","Bufalin","JHU395","SX-682","IMR-1A","Navitoclax (ABT-263)"]
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[]
[]
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[]
[]
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[{"$nulls":3},"AMG-9810","Navoximod","Ginsenoside Rk1","Pentostatin","IACS-13909","4-Hydroxyphenylpyruvic acid","Neticonazole","Remdesivir (GS-5734)","CDDO-Im","EC330"]
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[{"$nulls":3},"Lanreotide","Atamparib (RBN-2397)","Berberrubine","DRB18","Fluzoparib (SHR-3162)","cis-Resveratrol","Crizotinib hydrochloride","SRX3207","SZL P1-41","SKI-V"]
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[{"$nulls":3},"β-Elemene","Prim-o-glucosylcimifugin","Isoliensinine","CBR-5884","TK216","Metarrestin (ML246)","Megestrol","(Z)-4-Hydroxytamoxifen","Indisulam","m-3M3FBS"]
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[]
[]
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[{"$nulls":3},"MT-802","MS140","CP-31398 Dihydrochloride","NS6180","Tyrphostin AG1433","TAK-960","SIS3","HLY78","Venadaparib(IDX-1197)","Flumatinib (HH-GV-678)"]
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[{"$nulls":3},"A939572","MYLS22","OT-82","BTR-1","Camalexin","Fenoldopam","Poloxin","FIIN-3","VB124","NiCur"]
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[]
[]
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[{"$nulls":3},"β-Anhydroicaritin","Vercirnon","Calmidazolium chloride","Prednicarbate","Nomegestrol Acetate","N-Desmethyltamoxifen","Masitinib mesylate","TRULI","CHR-6494","CAY10444"]
[null,"e","Empty","E0247","E0400","E0484","E0531","E0749","E0789","E0822","E1063","E1136","E1166","Empty"]
[{"$nulls":3},"Militarine","AS1949490","CNQX","TMS","Coumalic acid","SC-58125","AST-1306","Piperazine Erastin","SKLB-197","tetrathiomolybdate"]
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[{"$nulls":3},"BAMB-4","BI6015","C-021","Methyl methanesulfonate","Dihydrouracil","ILK-IN-3","Mitonafide","SBP-3264","GSK2033","R162"]
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[{"$nulls":3},"AKI603","Robinetin","SP-8356","γ-Terpinene","Silydianin","SW-106065","Compound 10w","MiTMAB","CHD1Li 6.11","FHD-286"]
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[{"$nulls":3},"DPPE fumarate","Adarotene","Firocoxib (ML 1785713)","Trans-ferulic acid","Neotuberostemonine","G5-7","IMD-0560","5-amino-2,4-dimethylpyridine (5A-DMP)","SIRT7 inhibitor 97491","TES-1025"]
[]
[]
[]
[null,"Plate layout: L3000-47"]
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[null,"a","Empty","E1190","E2374","E2548","E2664","E2833","P1153","S3290","S7817","S8983","S0078","Empty"]
[{"$nulls":3},"UC2288","PI-273","N-(p-Coumaroyl) Serotonin","Cridanimod","1,5-Anhydro-D-glucitol","PKG inhibitor peptide","Procyanidin B2","MI-503","MAK683","1V209 (TLR7 agonist T7)"]
[null,"b","Empty","E1281","E2376","E2631","E2682","E2847","P1161","S6918","S8162","S9014","S0356","Empty"]
[{"$nulls":3},"Dimethyl itaconate","KY-05009","Colcemid","RPI-1","TPPU","Angstrom6","Oleandrin (PBI-05204)","Upadacitinib (ABT-494)","AstragalosideⅠ","Pulrodemstat (CC-90011) besylate"]
[null,"c","Empty","E2037","E2388","E2632","E2684","P1107","P1216","S7048","S8297","S9213","S0428","Empty"]
[{"$nulls":3},"Kisspeptin-10 (human)","PKR-IN-2","Norharmane","Icilin","Alamandine","Box5","Talazoparib (BMN 673)","ARV-825","Jujuboside A","Etalocib"]
[null,"d","Empty","E2147","E2393","E2633","E2697","P1110","P1236","S7062","S8553","S9659","S0504","Empty"]
[{"$nulls":3},"AZD-9574","JNJ-10198409","Tris(2-chloroethyl) phosphate","TCPP","Etelcalcetide HCl","CYN154806","Pinometostat (EPZ5676)","Avapritinib (BLU-285)","UNC6852","SU14813"]
[null,"e","Empty","E2203","E2400","E2641","E2699","P1116","S0947","S7101","S8587","S9690","S0733","Empty"]
[{"$nulls":3},"DMU-212","1A-116","trans-Chalcone","Tris(2-butoxyethyl) phosphate","Epitalon","Cafestol","SCH772984","Withaferin A","Caerulein (FI-6934)","Tegatrabetan (BC-2059)"]
[null,"f","Empty","E2354","E2402","E2642","E2826","P1134","S0969","S7108","S8719","E0201","S0872","Empty"]
[{"$nulls":3},"Valepotriate","T-1101 tosylate","CGP60474","Hematein","diprotin A","Heterophyllin B","Encorafenib (LGX818)","AZD4573","Hypaconitine","ASTX-029"]
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[{"$nulls":3},"Glutaminase C-IN-1","ZINC05007751","DMAT","Alkannin","HIV Peptide T","Calcifediol","Rocaglamide","MC180295","Quercetagetin","Cyclophosphamide"]
[null,"h","Empty","E2373","E2516","E2663","E2832","P1152","S2841","S7580","S8833","E2748","S1522","Empty"]
[{"$nulls":3},"CAN508","Doxorubicin","BT2","LCS-1","Oglufanide","Bemcentinib (R428)","Leptomycin B","TAS0728","EGCG Octaacetate","Tosedostat (CHR2797)"]
[]
[]
[]
[null,"Plate layout: L3000-48"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1575","S3522","S6839","S7736","S8532","S8718","S8858","S8955","S9650","E0142","Empty"]
[{"$nulls":3},"RO4929097","2OH-BNPP1","MRX-2843","MLN120B","ARV-771","RMC-4550","GSK3368715 (EPZ019997) 3HCl","Sotorasib (AMG510) racemate","LY3143921 hydrate","XL092"]
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[{"$nulls":3},"Apatinib (YN968D1) mesylate","AZD7507","OSU-T315","A-1331852","TVB-3664","Imaradenant (AZD4635)","Cintirorgon (LYC-55716)","Camizestrant (AZD9833)","BMS-986158","PF-9363 (CTx-648)"]
[null,"c","Empty","S2653","S3576","S6897","S7926","S8636","S8722","S8869","S8987","S9726","E0369","Empty"]
[{"$nulls":3},"9-amino-CPT (9-Aminocamptothecin)","TVB-3166","Epertinib hydrochloride","Lifirafenib (BGB-283)","Selitrectinib (LOXO-195)","Samuraciclib hydrochloride (ICEC0942 hydrochloride)","UNBS5162","TNO155","Rimiducid (AP1903)","Endovion (NS 3728)"]
[null,"d","Empty","S2733","S4455","S6961","S7930","S8665","S8782","S8881","S8999","S9825","E0488","Empty"]
[{"$nulls":3},"AV-412 free base","iGOT1-01","Foxy-5","Ixabepilone (BMS-247550)","GNE-781","LY3295668","DS-1001b (DS 1001)","Exatecan Mesylate","Pirtobrutinib (LOXO-305)","BC-LI-0186"]
[null,"e","Empty","S2975","S4476","S6984","S8064","S8681","S8829","S8884","S9522","S9867","E0496","Empty"]
[{"$nulls":3},"CarboxyaMidotriazole orotate","PCNA-I1","Dianhydrogalactitol (VAL-083)","Midostaurin (PKC412)","Tolinapant (ASTX660)","Subasumstat (TAK-981)","Adagrasib (MRTX849)","Valrubicin","LY-3475070","ZLc002"]
[null,"f","Empty","S3020","S6248","S7109","S8129","S8707","S8830","S8925","S9608","S9901","E0499","Empty"]
[{"$nulls":3},"Romidepsin","Fasnall","Pevonedistat (MLN4924)","Salinomycin (from Streptomyces albus)","ARS-1620","Sotorasib (AMG510)","Simurosertib","Etrumadenant (AB928)","KB-0742 Dihydrochloride","4SC-203"]
[null,"g","Empty","S3494","S6594","S7554","S8341","S8708","S8834","S8926","S9629","S9970","E0616","Empty"]
[{"$nulls":3},"Vicriviroc maleate","Liarozole dihydrochloride","Ravoxertinib (GDC-0994)","TAK-243 (MLN7243)","AZD0364 (ATG-017)","GB1107","Valemetostat (DS-3201)","Elacestrant (RAD1901) Dihydrochloride","APG-2575 (lisaftoclax)","Chiauranib"]
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[{"$nulls":3},"AZ10606120 dihydrochloride","VcMMAE","SAR405","Edicotinib(JNJ-40346527)","Pralsetinib (BLU-667)","TAS4464","VTP50469","BRD0705","ASN007","Melengestrol Acetate"]
[]
[]
[]
[null,"Plate layout: L3000-49"]
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[{"$nulls":3},"Zn-C3","MRTX0902","FR054","R1530","BGB 15025","A2ti-1","Deutenzalutamide","Didox","PCLX-001 (DDD86481)","AOH1996"]
[null,"b","Empty","E1037","E1184","E2375","E2658","E1305","E1425","E2430","E2943","E1478","E1598","Empty"]
[{"$nulls":3},"ZZW-115","CFT7455","PI3K/mTOR Inhibitor-2","FN-1501","RBN013209","Nesuparib","Allocholic acid","Pifithrin-β","BDTX-1535","VT103"]
[null,"c","Empty","E1091","E1191","E2397","E2821","E1322","E1427","E2862","E2954","E1480","E1603","Empty"]
[{"$nulls":3},"Relacorilant","GDC-1971","hVEGF-IN-1","RGB-286638 free base","GS-4224","MRT-2359","(+/-)-Naringenin","Ethyl methanesulfonate","DJ4","ACT001(DMAMCL)"]
[null,"d","Empty","E1103","E1204","E2398","P1005","E1328","E1428","E2880","E4010","E1512","E1605","Empty"]
[{"$nulls":3},"AU-15330","NVP-DKY709","STAT5-IN-2","Abarelix Acetate","TP-1454","Mps1-IN-6 (Compound 9)","methylnaltrexone bromide","L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride","M3541","Avotaciclib trihydrochloride"]
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[{"$nulls":3},"GSK215","BAY 2666605","Falnidamol","Antide","K-975","T1-44","bisBenzimide H 33258 Trihydrochloride","N-p-Tosyl-L-phenylalanine chloromethyl ketone","PRGL493","Exarafenib"]
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[{"$nulls":3},"BAY-179","NPX800","NVP-LCQ195","LDC203974 (IMT1B)","Usp22i-S02","A2ti-2","5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside","KCC-07","AZD0095","Opevesostat (ODM208)"]
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[{"$nulls":3},"EZM0414","CC-99282","Ginsenoside Rg3","CIA1","ISA-2011B","MSU-42011","SI-2 Hydrochloride","APS6-45","FSEN1","CD532"]
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[{"$nulls":3},"Sovilnesib","Ro5-3335","Vimseltinib","MDL-800","Tuvusertib","IDE397 (GSK-4362676)","MOMIPP","CA-170 (AUPM-170)","garsorasib (D-1553 )","PRT543"]
[]
[]
[]
[null,"Plate layout: L3000-50"]
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[{"$nulls":3},"LY2880070","PK11007","Infigratinib Phosphate","RMC-4630","Zamaporvint (RXC004)"]
[null,"b","Empty","E1684","E1739","E4477","E0305","E1497","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"C1632","MST-312","Lumateperone","UNC 3230","Tulmimetostat"]
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[{"$nulls":3},"BAY 2965501","Reversan","MYCMI-6","POMHEX","ZEN-3694"]
[null,"d","Empty","E1716","E1812","S3575","E1203","E1537","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"SR9011","N6F11","Zandelisib","Sirpiglenastat","MMRi62"]
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[{"$nulls":3},"Pimicotinib","Cirtuvivint","INDY","Zidesamtinib","Sildenafil"]
[null,"f","Empty","E1731","E4024","S8545","E1469","S7654","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"JW74","Poly-D-lysine hydrobromide","TEN-010 (RG6146,Ro-6870810,(S)-JQ-35)","ITF3756","Defactinib (VS-6063)"]
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[{"$nulls":3},"Itacnosertib (TP-0184)","CSRM617 hydrochloride","Acriflavine","EP4-IN-1"]
[null,"h","Empty","E1733","E4467","S9741","E1483","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"PBIT","Temozolomide Acid","TAS-119","IK-930"]
[]
[]
[]
[null,"Plate layout: L3000-51"]
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[{"$nulls":3},"Perifosine (KRX-0401)","Varenicline Tartrate (CP 526555-18)","Penicillamine","Clindamycin Phosphate","Methacycline HCl","Danofloxacin Mesylate","Acamprosate Calcium","Gentamicin Sulfate","Chloroquine diphosphate","Pralidoxime chloride"]
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[{"$nulls":3},"Palbociclib (PD-0332991) HCl","Ralimetinib (LY2228820) dimesylate","Etidronate","Lisinopril dihydrate","Lomefloxacin HCl","(R)-baclofen","isoleucine","Hexamethonium Dibromide","Ceftriaxone disodium salt hemi (heptahydrate)","Eflornithine (MDL-71782) hydrochloride hydrate"]
[null,"c","Empty","S1135","S1506","S1875","S2129","S2877","S3146","S3861","S4094","S4183","S4606","Empty"]
[{"$nulls":3},"Pemetrexed (LY-231514) disodium","Perindopril Erbumine","Tranexamic Acid","Fudosteine","L-NAME HCl","Tripelennamine HCl","Sodium Demethylcantharidate","Tetramisole HCl","Paromomycin Sulfate","Glutathione"]
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[{"$nulls":3},"Gemcitabine (LY-188011) HCl","Cidofovir","Ticlopidine HCl","Gabapentin","AMD3465 hexahydrobromide","Ibandronate sodium monohydrate","DL-Glutamine","Clodronate Disodium","Proflavine Hemisulfate","L-Ornithine hydrochloride"]
[null,"e","Empty","S1311","S1518","S1995","S2420","S3013","S3174","S3973","S4117","S4245","S4671","Empty"]
[{"$nulls":3},"Pamidronate Disodium","Ibuprofen Lysine","Procarbazine HCl","Aloperine","Plerixafor (AMD3100) 8HCl","L-Arginine HCl (L-Arg)","L-SelenoMethionine","Histamine Phosphate","Sodium ascorbate","Cefradine"]
[null,"f","Empty","S1339","S1579","S1999","S2462","S3048","S3649","S4008","S4121","S4254","S4700","Empty"]
[{"$nulls":3},"Galanthamine HBr","Palbociclib (PD0332991) Isethionate","Sodium butyrate","Donepezil HCl","Solifenacin succinate","Ceftazidime","Pemirolast potassium","Succinylcholine Chloride Dihydrate","Apramycin Sulfate","4-Aminobutyric acid (GABA)"]
[null,"g","Empty","S1345","S1624","S2000","S2490","S3050","S3662","S4027","S4127","S4360","S4702","Empty"]
[{"$nulls":3},"Granisetron HCl","Alendronate sodium trihydrate","Sodium orthovanadate","Neostigmine Bromide","Palonosetron HCl","Pirenzepine dihydrochloride","Flavoxate HCl","Terbutaline Sulfate","Tolmetin Sodium","Sarcosine"]
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[{"$nulls":3},"Dorzolamide HCl","Cytarabine (U-19920A)","Taurine","Salbutamol Sulfate","Miltefosine","Imipenem","Dexamethasone Sodium Phosphate","Amprolium HCl","Hydroxychloroquine Sulfate (NSC 4375)","Sodium ferulate"]
[]
[]
[]
[null,"Plate layout: L3000-52"]
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[{"$nulls":3},"Danshensu","Nylidrin Hydrochloride","Clodronate disodium tetrahydrate","Dorsomorphin (Compound C) 2HCl","Ruxotemitide (LTX 315)","Eptifibatide Acetate","Foscarnet Sodium","L-2-Hydroxyglutaric acid disodium","Gentamicin","gp91ds-tat"]
[null,"b","Empty","S4786","S5384","S5706","S7362","S8442","P1017","S4519","S2996","S6872","S8164","Empty"]
[{"$nulls":3},"S-Methyl-L-cysteine","UTP Trisodium Salt","Edetate Trisodium","AZD5582","TAK-659","Octreotide (SMS 201-995) acetate","Citric acid trilithium salt tetrahydrate","L-DAB HBR","Merbromin","YAP-TEAD Inhibitor 1 (Peptide 17)"]
[null,"c","Empty","S4791","S5524","S6023","S7507","S8454","P1025","S2441","S3096","E0532","S8197","Empty"]
[{"$nulls":3},"S-allyl-L-cysteine","Spermine Tetrahydrochloride","Creatine monohydrate","LDN-193189 2HCl","ATN-161 (Ac-PHSCN-NH2)","Atosiban Acetate","Estramustine phosphate sodium","L-Histidine monohydrochloride monohydrate","Menotropin","APTSTAT3-9R"]
[null,"d","Empty","S4993","S5526","S6129","S7537","S8501","P1030","S8670","S3346","E0654","S8416","Empty"]
[{"$nulls":3},"Timonacic","β-Alanine","Aminomalonic acid","LB-100","Adaptavir (DAPTA)","Salmon Calcitonin Acetate","Vipivotide tetraxetan (PSMA-617)","1-Methylnicotinamide chloride","D-Arginine","PACAP 6-38"]
[null,"e","Empty","S5097","S5533","S6334","S7547","S8549","P1039","S6894","S8415","E2638","S8505","Empty"]
[{"$nulls":3},"Methotrexate disodium","Tobramycin sulfate","DL-Norvaline","XL413 (BMS-863233)","AUNP-12","Somatostatin Acetate","BCH","PACAP 1-38","Tricine","LY2510924"]
[null,"f","Empty","S5131","S5545","S6445","S7785","S8651","P1084","S8620","S9728","E2688","S9725","Empty"]
[{"$nulls":3},"Homotaurine","DL-Serine","Chlorophyllin (sodium copper salt)","Pemetrexed Disodium Hydrate","bpV (HOpic)","Desmopressin Acetate","6-Diazo-5-oxo-L-norleucine","BSO (L-Buthionine-(S,R)-sulfoximine)","Glufosinate-ammonium","Balixafortide (POL6326)"]
[null,"g","Empty","S5136","S5572","S6488","S7873","S8674","P1085","S9665","P1202","E2830","E1223","Empty"]
[{"$nulls":3},"Calcium folinate","Azetidine-2-carboxylic acid","Gadoxetate sodium","Disodium (R)-2-Hydroxyglutarate","GO-203","Angiotensin II human Acetate","Motixafortide (BL-8040)","TMPyP4 tosylate","Cyclocreatine","RGX-202"]
[null,"h","Empty","S5137","S5584","S7204","S8008","S9353","S1671","P1088","S1314","P1137","S5961","Empty"]
[{"$nulls":3},"O-Phospho-L-serine","Citronellol","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","RGD (Arg-Gly-Asp) Peptides","L-serine","(6-)ε-​Aminocaproic acid","Lanreotide acetate","Zoledronic acid (ZOL 446)","Thymulin","Prednisolone disodium phosphate"]
[]
[]
[]
[null,"Plate layout: L3000-53"]
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[{"$nulls":3},"NSC16168"]
[null,"b","Empty","S2542","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Phenformin (NSC-756501) HCl"]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[]
[]
[]
[null,"Plate layout: L3000-54"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1019","S1211","S1507","S1724","S2157","S2597","S2805","S3770","S4642","S6642","Empty"]
[{"$nulls":3},"Canertinib (CI-1033)","Imiquimod (R-837)","Irbesartan","Paliperidone","Taladegib (LY2940680)","Oseltamivir Phosphate","LY364947","Sodium Aescinate","Dolutegravir Sodium","Branaplam (LMI070)"]
[null,"b","Empty","S1023","S1288","S1509","S1837","S2206","S2628","S2827","S3801","S5018","S7004","Empty"]
[{"$nulls":3},"Erlotinib (OSI-774) HCl","Camptothecin (NSC-100880)","Norfloxacin","Flubendazole","Fostamatinib (R788) disodium","Gedatolisib (PKI-587)","Torin 1","Sodium Houttuyfonate","Mebhydrolin napadisylate","EPZ005687"]
[null,"c","Empty","S1043","S1327","S1519","S1851","S2251","S2638","S2870","S3821","S5232","S7035","Empty"]
[{"$nulls":3},"Tandutinib (MLN518)","Ellagic acid","CCT129202","Oxibendazole","(-)-Huperzine A (HupA)","NU7441 (KU-57788)","TG100713","Nuciferine","Alectinib (CH5424802) hydrochloride","XL388"]
[null,"d","Empty","S1046","S1353","S1615","S1977","S2292","S2684","S2893","S3891","S5249","S7061","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)","Ketoconazole (R 41400)","Risperidone","Sarafloxacin HCl","Diosmin","Pidnarulex (CX-5461)","NU7026","Vincamine","Coptisine chloride","GSK126"]
[null,"e","Empty","S1108","S1360","S1617","S1986","S2395","S2704","S2920","S4033","S5272","S7085","Empty"]
[{"$nulls":3},"TAE684 (NVP-TAE684)","GSK1059615","Sulfapyridine","Meclizine 2HCl","Rheochrysidin","LY2109761","Mozavaptan","Sennoside A","Toceranib phosphate","IWP-2"]
[null,"f","Empty","S1112","S1424","S1642","S2047","S2476","S2735","S3042","S4126","S5516","S7105","Empty"]
[{"$nulls":3},"SGX-523","Prazosin HCl","Methyldopa","Lornoxicam","Itraconazole (R 51211)","MK-8776 (SCH 900776)","Purmorphamine","Retinyl (Vitamin A) Palmitate","Ellagic Acid hydrate","BAM7"]
[null,"g","Empty","S1118","S1463","S1698","S2110","S2530","S2744","S3059","S4262","S5577","S7128","Empty"]
[{"$nulls":3},"XL147 analogue","Ofloxacin","Torsemide","Vinpocetine","7-Aminocephalosporanic acid","CCT137690","Enrofloxacin","Ebastine","6-Biopterin","Tazemetostat (EPZ-6438)"]
[null,"h","Empty","S1205","S1464","S1707","S2150","S2582","S2788","S3614","S4605","S5677","S7164","Empty"]
[{"$nulls":3},"PIK-75 HCl","Marbofloxacin","Eplerenone (CGP 30083)","Neratinib (HKI-272)","Trazodone HCl","Capmatinib (INCB28060)","Lupeol","Folic acid","Xanthopterin Hydrate","GSK343"]
[]
[]
[]
[null,"Plate layout: L3000-55"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S7221","S7819","S8568","S3299","S6385","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Vesatolimod (GS-9620)","BLU9931","G1T38","Demethyleneberberine","Prexasertib (LY2606368)"]
[null,"b","Empty","S7342","S7840","S8724","S3304","S6937","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"UNC2250","Dorsomorphin (Compound C)","Lazertinib","Stylopine","BI-3802"]
[null,"c","Empty","S7400","S7842","S9067","S6949","S7089","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"ISRIB (trans-isomer)","LY3009120","Pseudoprotodioscin","OTX008","SM-164"]
[null,"d","Empty","S7485","S7846","S9081","E0124","S9826","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"CCT007093","Dubermatinib(TP-0903)","Anemoside B4","Chelerythrine","TPX-0046"]
[null,"e","Empty","S7518","S8113","S9246","E0524","S9872","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Voreloxin (SNS-595) hydrochloride","BI-9564","Tiliroside","Spinosad","AG-270"]
[null,"f","Empty","S7698","S8229","S9257","S3309","S4586","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"LY2584702","Brigatinib (AP26113)","Acetylshikonin","Solasodine","4-Chloro-DL-phenylalanine"]
[null,"g","Empty","S7756","S8527","S5098","S7178","E1484","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Indoximod (NLG-8189）","ROC-325","Gefitinib hydrochloride","Prexasertib HCl (LY2606368)","PDS-0330"]
[null,"h","Empty","S7790","S8548","S1502","S3570","E1678","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"A-1210477","Roblitinib (FGF401)","Cephalexin","ARRY-382","SPOP-i-6lc"]
[]
[]
[]
[null,"Plate layout: L3000-56"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1911","S2095","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Disodium Cromoglycate","Fosinopril Sodium"]
[null,"b","Empty","S2106","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Azasetron HCl"]
[null,"c","Empty","S2562","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Hydralazine HCl"]
[null,"d","Empty","S4067","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Deferiprone"]
[null,"e","Empty","S4226","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Minocycline (CL 59806) HCl"]
[null,"f","Empty","S4694","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Alosetron Hydrochloride"]
[null,"g","Empty","S8030","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Plerixafor (AMD3100)"]
[null,"h","Empty","S5650","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Sodium Hyaluronate"]

{"sheet":"L3000-Anti-Cancer-4249 cpds ","index":1,"n_rows":4250,"n_cols":23,"rows_kept":4250}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1002","ABT-737","a2","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Mitophagy","Apoptosis","ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.",813.43,"852808-04-9",{"v":100,"d":"100.00"},122.94,"<1","N/A","http://selleckchem.com/products/ABT-737.html","C42H45ClN6O5S2","free base","N/A","CN(C)CCC(CSC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[S](=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=C(C=CC=C5)C6=CC=C(Cl)C=C6",8.198,3,2,16]
["S1003","Linifanib (ABT-869)","b2","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,CSF-1R,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.",375.41,"796967-16-3",{"v":75,"d":"75.00"},199.78,"<1","N/A","http://selleckchem.com/products/ABT-869.html","C21H18FN5O","free base","AL39324,RG3635","CC1=CC(=C(F)C=C1)NC(=O)NC2=CC=C(C=C2)C3=C4C(=N[NH]C4=CC=C3)N",4.169,2,4,3]
["S1004","Veliparib (ABT-888)","c2","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,PARP","DNA Damage/DNA Repair","Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.",244.29,"912444-00-9",{"v":17,"d":"17.00"},69.59,"<1","N/A","http://selleckchem.com/products/ABT-888.html","C13H16N4O","free base","NSC 737664","CC1(CCCN1)C2=NC3=C(C=CC=C3[NH]2)C(N)=O",0.986,2,3,2]
["S1005","Axitinib (AG 013736)","d2","L3000-01","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.",386.47,"319460-85-0",{"v":35,"d":"35.00"},90.56,"<1","N/A","http://selleckchem.com/products/Axitinib.html","C22H18N4OS","free base","AG 013736","CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=N[NH]3)\\C=C\\C4=CC=CC=N4",4.492,3,2,5]
["S1006","Saracatinib (AZD0530)","e2","L3000-01","in 10mM DMSO","Autophagy,EGFR,Src","Angiogenesis","Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.",542.03,"379231-04-6",{"v":35,"d":"35.00"},64.57,"<1","N/A","http://selleckchem.com/products/AZD0530.html","C27H32ClN5O5","free base","N/A","CN1CCN(CCOC2=CC(=C3C(=NC=NC3=C2)NC4=C(Cl)C=CC5=C4OCO5)OC6CCOCC6)CC1",3.814,7,1,8]
["S1007","Roxadustat (FG-4592)","f2","L3000-01","in 10mM DMSO","Ferroptosis,HIF","Angiogenesis","Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.",352.34,"808118-40-3",{"v":70,"d":"70.00"},198.67,"<1","N/A","http://selleckchem.com/products/fg-4592.html","C19H16N2O5","free base","ASP1517","CC1=NC(=C(O)C2=C1C=C(OC3=CC=CC=C3)C=C2)C(=O)NCC(O)=O",2.306,4,2,5]
["S1008","Selumetinib (AZD6244)","g2","L3000-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It  also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.",457.68,"606143-52-6",{"v":91,"d":"91.00"},198.83,"<1","N/A","http://selleckchem.com/products/AZD6244.html","C17H15BrClFN4O3","free base","ARRY-142886","C[N]1C=NC2=C(F)C(=C(C=C12)C(=O)NOCCO)NC3=CC=C(Br)C=C3Cl",3.234,3,3,6]
["S1010","Nintedanib (BIBF 1120)","h2","L3000-01","in 10mM DMSO","FGFR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","Nintedanib (BIBF 1120, Intedanib, Vargatef, Ofev) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.",539.62,"656247-17-5",{"v":6,"d":"6.00"},11.12,"<1","N/A","http://selleckchem.com/products/BIBF1120.html","C31H33N5O4","free base","Intedanib, Vargatef, Ofev","COC(=O)C1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(C)CC4)/C5=CC=CC=C5",2.965,4,2,8]
["S1011","Afatinib (BIBW2992)","a3","L3000-01","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.",485.94,"850140-72-6",{"v":97,"d":"97.00"},199.61,"<1","N/A","http://selleckchem.com/products/BIBW2992.html","C24H25ClFN5O3","Free Base","BIBW2992","CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC=C(F)C(=C3)Cl)N=CN=C2C=C1OC4CCOC4",3.917,5,2,8]
["S1012","BMS-536924","b3","L3000-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","BMS-536924 (CS-0117) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.",479.96,"468740-43-4",{"v":96,"d":"96.00"},200.02,"<1","N/A","http://selleckchem.com/products/BMS-536924.html","C25H26ClN5O3","free base","CS-0117","CC1=C2N=C([NH]C2=CC(=C1)N3CCOCC3)C4=C(NCC(O)C5=CC=CC(=C5)Cl)C=CNC4=O",2.385,3,4,6]
["S1013","Bortezomib (PS-341)","c3","L3000-01","in 10mM DMSO","Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome","Proteases","Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.",384.24,"179324-69-7",{"v":76,"d":"76.00"},197.79,"<1","N/A","http://selleckchem.com/products/Bortezomib.html","C19H25BN4O4","Free Base","Velcade, LDP-341, MLM341, NSC 681239,PS-341","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O",2.183,4,2,9]
["S1014","Bosutinib (SKI-606)","d3","L3000-01","in 10mM DMSO","Autophagy,Bcr-Abl,ERK,S6 Kinase,Src,STAT","Angiogenesis","Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.",530.45,"380843-75-4",{"v":100,"d":"100.00"},188.52,"<1","N/A","http://selleckchem.com/products/Bosutinib.html","C26H29Cl2N5O3","free base","SKI-606","COC1=C(Cl)C=C(Cl)C(=C1)NC2=C(C=NC3=CC(=C(OC)C=C23)OCCCN4CCN(C)CC4)C#N",4.883,4,1,9]
["S1017","Cediranib (AZD2171)","e3","L3000-01","in 10mM DMSO","Autophagy,c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.",450.51,"288383-20-0",{"v":90,"d":"90.00"},199.77,"<1","N/A","http://selleckchem.com/products/Cediranib.html","C25H27FN4O3","free base","NSC-732208","COC1=C(OCCCN2CCCC2)C=C3N=CN=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.761,5,1,8]
["S1018","Dovitinib (TKI-258)","f3","L3000-01","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.",392.43,"405169-16-6",{"v":30,"d":"30.00"},76.45,"<1","N/A","http://selleckchem.com/products/CHIR-258.html","C21H21FN6O","Citrate","CHIR-258","CN1CCN(CC1)C2=CC3=C(C=C2)N=C([NH]3)C4=C(N)C5=C(NC4=O)C=CC=C5F",1.781,2,3,2]
["S1020","PD184352 (CI-1040)","g3","L3000-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis.",478.67,"212631-79-3",{"v":96,"d":"96.00"},200.56,"<1","N/A","http://selleckchem.com/products/CI-1040-(PD184352).html","C17H14ClF2IN2O2","free base","N/A","FC1=CC=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl",4.907,2,2,6]
["S1021","Dasatinib (BMS-354825)","h3","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.",488.01,"302962-49-8",{"v":98,"d":"98.00"},200.82,"<1","N/A","http://selleckchem.com/products/Dasatinib.html","C22H26ClN7O2S","free base","BMS-354825","CC1=NC(=CC(=N1)N2CCN(CCO)CC2)NC3=NC=C(S3)C(=O)NC4=C(Cl)C=CC=C4C",3.439,4,3,7]
["S1022","Ridaforolimus (Deforolimus, MK-8669)","a4","L3000-01","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.",990.21,"572924-54-0",{"v":198,"d":"198.00"},199.96,"<1","N/A","http://selleckchem.com/products/Deforolimus.html","C53H84NO14P","free base","AP23573","COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.303,12,1,8]
["S1025","Gefitinib (ZD1839)","b4","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,EGFR","Protein Tyrosine Kinase","Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.",{"v":446.9,"d":"446.90"},"184475-35-2",{"v":89,"d":"89.00"},199.15,"<1","N/A","http://selleckchem.com/products/Gefitinib.html","C22H24ClFN4O3","free base","Iressa,ZD1839","COC1=C(OCCCN2CCOCC2)C=C3C(=NC=NC3=C1)NC4=CC=C(F)C(=C4)Cl",4.203,5,1,8]
["S1026","Imatinib (STI571) Mesylate","c4","L3000-01","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.",589.71,"220127-57-1",{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Imatinib-Mesylate.html","C29H31N7O.CH4SO3","Mesylate","Gleevec, Glivec, CGP-57148B,STI571","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5.C[S](O)(=O)=O",3.806,4,2,7]
["S1028","Lapatinib (GW-572016) Ditosylate","d4","L3000-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.",925.46,"388082-77-7",{"v":100,"d":"100.00"},108.05,"<1","N/A","http://selleckchem.com/products/Lapatinib-Ditosylate.html","C29H26ClFN4O4S.2C7H8O3S","Ditosylat","GW-572016","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(=C7)F)C(=C6)Cl)C5=C4",9.339,6,2,13]
["S1029","Lenalidomide (CC-5013)","e4","L3000-01","in 10mM DMSO","Apoptosis related,Caspase,E3 Ligase ,E3 ligase Ligand,TNF-alpha,VEGFR","Ubiquitin","Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.",259.26,"191732-72-6",{"v":52,"d":"52.00"},200.57,"<1","N/A","https://www.selleckchem.com/products/lenalidomide-s1029.html","C13H13N3O3","free base","CC-5013","NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",-0.515,3,2,1]
["S1030","Panobinostat (LBH589)","f4","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC,HIV Protease","Epigenetics","Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.",349.43,"404950-80-7",{"v":69,"d":"69.00"},197.46,"<1","N/A","http://selleckchem.com/products/LBH-589.html","C21H23N3O2","Free Base","NVP-LBH589","CC1=C(CCNCC2=CC=C(\\C=C\\C(=O)NO)C=C2)C3=C([NH]1)C=CC=C3",3.194,1,3,7]
["S1032","Motesanib Diphosphate (AMG-706)","g4","L3000-01","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3.",569.44,"857876-30-3",{"v":100,"d":"100.00"},175.61,{"v":19,"d":"19.00"},33.37,"http://selleckchem.com/products/Motesanib-Diphosphate.html","C22H23N5O.2H3PO4","Diphosphate","N/A","CC1(C)CNC2=CC(=CC=C12)NC(=O)C3=C(NCC4=CC=NC=C4)N=CC=C3.O[P](O)(O)=O.O[P](O)(O)=O",1.783,3,3,5]
["S1033","Nilotinib (AMN-107)","h4","L3000-01","in 10mM DMSO","AMPK,Autophagy,Bcr-Abl","Angiogenesis","Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.",529.52,"641571-10-0",{"v":27,"d":"27.00"},50.99,"<1","N/A","http://selleckchem.com/products/Nilotinib.html","C28H22F3N7O","free base","AMN-107","CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CC=C5",5.084,5,2,7]
["S1035","Pazopanib HCl (GW786034 HCl)","a5","L3000-01","in 10mM DMSO","Autophagy,c-Kit,CSF-1R,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.",473.98,"635702-64-6",{"v":17,"d":"17.00"},35.87,"<1","N/A","http://selleckchem.com/products/Pazopanib-Hydrochloride.html","C21H23N7O2S.HCl","Hydrochloride","GW786034 HCl","Cl.C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",4.123,5,2,5]
["S1036","Mirdametinib (PD0325901)","b5","L3000-01","in 10mM DMSO","MEK","MAPK","Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.",482.19,"391210-10-9",{"v":96,"d":"96.00"},199.09,"<1","N/A","http://selleckchem.com/products/PD-0325901.html","C16H14F3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C=C1)F",2.578,2,4,7]
["S1038","PI-103","c5","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.",348.36,"371935-74-9",{"v":24,"d":"24.00"},68.89,"<1","N/A","http://selleckchem.com/products/PI-103.html","C19H16N4O3","free base","N/A","OC1=CC(=CC=C1)C2=NC3=C(OC4=C3C=CC=N4)C(=N2)N5CCOCC5",2.798,5,1,2]
["S1039","Rapamycin (AY-22989)","d5","L3000-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1","N/A","http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1040","Sorafenib (BAY 43-9006) tosylate","e5","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate)  is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",637.03,"475207-59-1",{"v":127,"d":"127.00"},199.36,0.01,0.02,"http://selleckchem.com/products/Sorafenib-Tosylate.html","C21H16ClF3N4O3.C7H8O3S","Tosylate","BAY 43-9006 tosylate,NSC-724772 tosylate","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O",5.824,4,3,7]
["S1041","STF-62247","f5","L3000-01","in 10mM DMSO","Autophagy","Autophagy","STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).",267.35,"315702-99-9",{"v":53,"d":"53.00"},198.24,"<1","N/A","http://selleckchem.com/products/STF-62247.html","C15H13N3S","free base","N/A","CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3",3.659,2,1,3]
["S1042","Sunitinib (SU11248) malate","g5","L3000-01","in 10mM DMSO","Apoptosis related,c-Kit,IRE1,Mitophagy,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.",532.56,"341031-54-7",{"v":15,"d":"15.00"},28.17,"<1","N/A","http://selleckchem.com/products/Sunitinib-Malate-(Sutent).html","C22H27FN4O2.C4H6O5","Malate","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=CC=C(F)C=C23.OC(CC(O)=O)C(O)=O",-1.049,4,4,10]
["S1044","Temsirolimus (CCI-779)","h5","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis.",1030.29,"162635-04-3",{"v":67,"d":"67.00"},65.03,"<1","N/A","http://selleckchem.com/products/Temsirolimus.html","C56H87NO16","free base","NSC 683864,CCI-779","COC1CC(CCC1OC(=O)C(C)(CO)CO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.039,12,3,11]
["S1047","Vorinostat (SAHA)","a6","L3000-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1","N/A","http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1048","Tozasertib","b6","L3000-01","in 10mM DMSO","Aurora Kinase,Autophagy,Bcr-Abl,FLT3","Cell Cycle","Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.",464.59,"639089-54-6",{"v":93,"d":"93.00"},200.18,"<1","N/A","http://selleckchem.com/products/VX-680(MK-0457).html","C23H28N8OS","free base","VX-680, MK-0457","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)SC4=CC=C(NC(=O)C5CC5)C=C4",4.445,4,3,7]
["S1049","Y-27632 2HCl","c6","L3000-01","in 10mM DMSO","Autophagy,ROCK","Cell Cycle","Y-27632 2HCl is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",320.26,"129830-38-2",{"v":64,"d":"64.00"},199.84,{"v":14,"d":"14.00"},43.71,"http://selleckchem.com/products/Y-27632.html","C14H21N3O.2HCl","Dihydrochloride","N/A","Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.871,2,2,3]
["S1052","Elesclomol (STA-4783)","d6","L3000-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.",{"v":400.5,"d":"400.50"},"488832-69-5",{"v":80,"d":"80.00"},199.75,"<1","N/A","http://selleckchem.com/products/Elesclomol.html","C19H20N4O2S2","free base","N/A","CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2",2.885,2,2,8]
["S1053","Entinostat (MS-275)","e6","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.",376.41,"209783-80-2",{"v":75,"d":"75.00"},199.25,"<1","N/A","http://selleckchem.com/products/MS-275.html","C21H20N4O3","free base","SNDX-275","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC(=O)OCC3=CN=CC=C3)C=C2",2.071,4,3,7]
["S1055","Enzastaurin (LY317615)","f6","L3000-01","in 10mM DMSO","PKC","TGF-beta/Smad","Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.",515.61,"170364-57-5",{"v":30,"d":"30.00"},58.18,"<1","N/A","http://selleckchem.com/products/Enzastaurin.html","C32H29N5O2","free base","N/A","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](C5CCN(CC5)CC6=NC=CC=C6)C7=CC=CC=C47",{"v":4.32,"d":"4.320"},3,1,5]
["S1056","AC480 (BMS-599626)","g6","L3000-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.",530.55,"714971-09-2",{"v":113,"d":"113.00"},212.99,"<1","N/A","http://selleckchem.com/products/BMS-599626.html","C27H27FN8O3","free base","N/A","CC1=C2[N](C=C1NC(=O)OCC3COCCN3)N=CN=C2NC4=CC5=C(C=C4)[N](CC6=CC=CC(=C6)F)N=C5",3.726,6,3,8]
["S1057","Obatoclax Mesylate (GX15-070)","h6","L3000-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1","N/A","http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","a7","L3000-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,"N/A","N/A","http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1061","Nutlin-3","b7","L3000-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1064","Masitinib (AB1010)","c7","L3000-01","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","Masitinib is a novel inhibitor for Kit (c-Kit) and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3.",498.64,"790299-79-5",{"v":100,"d":"100.00"},200.55,"<1","N/A","http://selleckchem.com/products/Masitinib-(AB1010).html","C28H30N6OS","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC(=C(C)C=C3)NC4=NC(=CS4)C5=CC=CN=C5",4.475,3,2,7]
["S1065","Pictilisib (GDC-0941)","d7","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,PI3K","PI3K/Akt/mTOR","Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.",513.64,"957054-30-7",{"v":44,"d":"44.00"},85.66,"<1","N/A","http://selleckchem.com/products/GDC-0941.html","C23H27N7O3S2","free base","RG7321","C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6",2.153,6,1,5]
["S1066","SL-327","e7","L3000-01","in 10mM DMSO","MEK","MAPK","SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.",335.35,"305350-87-2",{"v":67,"d":"67.00"},199.79,"<1","N/A","http://selleckchem.com/products/SL327.html","C16H12F3N3S","free base","N/A","NC(\\SC1=CC=C(N)C=C1)=C(C#N)/C2=C(C=CC=C2)C(F)(F)F",3.705,0,2,4]
["S1067","SB431542","f7","L3000-01","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.",384.39,"301836-41-9",{"v":76,"d":"76.00"},197.72,"<1","N/A","http://selleckchem.com/products/SB-431542.html","C22H16N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=NC=CC=C3)C4=CC5=C(OCO5)C=C4",3.447,5,2,4]
["S1068","Crizotinib (PF-02341066)","g7","L3000-01","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",450.34,"877399-52-5",{"v":9,"d":"9.00"},19.98,"<1","N/A","http://selleckchem.com/products/PF-2341066.html","C21H22Cl2FN5O","free base","PF-02341066","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S1069","Luminespib (NVP-AUY922)","h7","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),IGF-1R","Cytoskeletal Signaling","Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.",465.54,"747412-49-3",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/NVP-AUY922.html","C26H31N3O5","free base","AUY-922, VER-52296","CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C",4.069,4,3,7]
["S1070","PHA-665752","a8","L3000-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays,  >50-fold selectivity for c-Met than RTKs or STKs.",641.61,"477575-56-7",{"v":128,"d":"128.00"},{"v":199.5,"d":"199.50"},"<1","N/A","http://selleckchem.com/products/PHA-665752.html","C32H34Cl2N4O4S","free base","N/A","CC1=C(C(=C([NH]1)/C=C/2C(=O)NC3=C2C=C(C=C3)[S](=O)(=O)CC4=C(Cl)C=CC=C4Cl)C)C(=O)N5CCCC5CN6CCCC6",5.689,4,2,7]
["S1071","HA14-1","b8","L3000-01","in 10mM DMSO","Bcl-2","Apoptosis","HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.",409.23,"65673-63-4",{"v":82,"d":"82.00"},200.38,"<1","N/A","http://selleckchem.com/products/HA14-1.html","C17H17BrN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Br",2.511,5,1,7]
["S1072","ZSTK474","c8","L3000-01","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2.",417.41,"475110-96-4",{"v":21,"d":"21.00"},50.31,"<1","N/A","http://selleckchem.com/products/ZSTK474.html","C19H21F2N7O2","free base","N/A","FC(F)C1=NC2=C(C=CC=C2)[N]1C3=NC(=NC(=N3)N4CCOCC4)N5CCOCC5",3.366,6,0,4]
["S1075","SB216763","d8","L3000-01","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.",371.22,"280744-09-4",{"v":23,"d":"23.00"},61.96,"<1","N/A","http://selleckchem.com/products/SB-216763.html","C19H12N2O2Cl2","free base","N/A","C[N]1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CC=C(Cl)C=C4Cl",4.391,2,1,2]
["S1076","Adezmapimod (SB203580)","e8","L3000-01","in 10mM DMSO","Mitophagy,p38 MAPK","MAPK","Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.",377.43,"152121-47-6",{"v":43,"d":"43.00"},113.93,"<1","N/A","http://selleckchem.com/products/SB-203580.html","C21H16FN3OS","Free Base","RWJ 64809, PB 203580","C[S](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",3.883,3,1,4]
["S1077","SB202190 (FHPI)","f8","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,p38 MAPK","MAPK","SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.",331.34,"152121-30-7",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/SB-202190.html","C20H14N3OF","free base","N/A","OC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",4.211,2,2,3]
["S1078","MK-2206 2HCl","g8","L3000-01","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.",480.39,"1032350-13-2",{"v":14,"d":"14.00"},29.14,"<1","N/A","http://selleckchem.com/products/MK-2206.html","C25H21N5O.2HCl","Dihydrochloride","N/A","Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6",4.183,3,2,3]
["S1080","SU11274","h8","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Met","Protein Tyrosine Kinase","SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest.",568.09,"658084-23-2",{"v":92,"d":"92.00"},161.95,"<1","N/A","http://selleckchem.com/products/SU11274.html","C28H30CIN5O4S","free base","PKI-SU11274","CN1CCN(CC1)C(=O)C2=C(C)[NH]C(=C2C)/C=C/3C(=O)NC4=C3C=C(C=C4)[S](=O)(=O)N(C)C5=CC(=CC=C5)Cl",3.477,4,2,5]
["S1082","Vismodegib (GDC-0449)","a9","L3000-01","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.",{"v":421.3,"d":"421.30"},"879085-55-9",{"v":84,"d":"84.00"},199.38,"<1","N/A","http://selleckchem.com/products/GDC-0449.html","C19H14Cl2N2O3S","free base","GDC-0449","C[S](=O)(=O)C1=CC=C(C(=C1)Cl)C(=O)NC2=CC(=C(Cl)C=C2)C3=NC=CC=C3",4.265,4,1,4]
["S1084","Brivanib (BMS-540215)","b9","L3000-01","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.",370.38,"649735-46-6",{"v":74,"d":"74.00"},199.79,"<1","N/A","http://selleckchem.com/products/Brivanib.html","C19H19FN4O3","free base","N/A","CC(O)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.481,4,2,5]
["S1085","Belinostat (PXD101)","c9","L3000-01","in 10mM DMSO","Autophagy,HDAC","Epigenetics","Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.",318.35,"866323-14-0",{"v":64,"d":"64.00"},201.04,"<1","N/A","http://selleckchem.com/products/Belinostat.html","C15H14N2O4S","free base","PXD101,NSC726630, PX-105684","ONC(=O)/C=C/C1=CC(=CC=C1)[S](=O)(=O)NC2=CC=CC=C2",{"v":1.8,"d":"1.800"},3,2,5]
["S1087","Iniparib (BSI-201)","d9","L3000-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Iniparib (BSI-201, NSC-746045, IND-71677) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.",292.03,"160003-66-7",{"v":58,"d":"58.00"},198.61,"<1","N/A","http://selleckchem.com/products/BSI-201.html","C7H5IN2O3","free base","NSC-746045, IND-71677","NC(=O)C1=CC(=C(I)C=C1)[N+]([O-])=O",1.304,1,1,2]
["S1088","NVP-ADW742","e9","L3000-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","NVP-ADW742 (GSK 552602A) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR;  little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.",453.58,"475488-23-4",{"v":10,"d":"10.00"},22.05,"<1","N/A","http://selleckchem.com/products/NVP-ADW742.html","C28H31N5O","Free Base","GSK 552602A, ADW742","NC1=NC=NC2=C1C(=C[N]2C3CC(C3)CN4CCCC4)C5=CC(=CC=C5)OCC6=CC=CC=C6",4.806,3,1,7]
["S1089","Refametinib (RDEA119)","f9","L3000-01","in 10mM DMSO","MEK","MAPK","Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.",572.34,"923032-37-5",{"v":100,"d":"100.00"},174.72,"<1","N/A","http://selleckchem.com/products/refametinib-rdea119-bay86-9766.html","C19H20F3IN2O5S","free base","Bay 86-9766","COC1=C(N[S](=O)(=O)C2(CC2)CC(O)CO)C(=C(F)C(=C1)F)NC3=CC=C(I)C=C3F",2.827,3,4,9]
["S1090","Abexinostat (PCI-24781)","g9","L3000-01","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.",397.42,"783355-60-2",{"v":80,"d":"80.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/PCI-24781.html","C21H23N3O5","free base","CRA-024781","CN(C)CC1=C(OC2=CC=CC=C12)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO",2.353,4,2,8]
["S1091","Linsitinib (OSI-906)","h9","L3000-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.",421.49,"867160-71-2",{"v":84,"d":"84.00"},199.29,"<1","N/A","http://selleckchem.com/products/OSI-906.html","C26H23N5O","free base","N/A","CC1(O)CC(C1)C2=NC(=C3[N]2C=CN=C3N)C4=CC=C5C=CC(=NC5=C4)C6=CC=CC=C6",3.757,3,1,3]
["S1092","KU-55933 (ATM Kinase Inhibitor)","a10","L3000-01","in 10mM DMSO","ATM/ATR,Autophagy,ULK","DNA Damage/DNA Repair","KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.",395.49,"587871-26-9",{"v":33,"d":"33.00"},83.44,"<1","N/A","http://selleckchem.com/products/KU-55933.html","C21H17NO3S2","free base","N/A","O=C1C=C(OC(=C1)C2=CC=CC3=C2SC4=CC=CC=C4S3)N5CCOCC5",4.393,3,0,2]
["S1093","GSK1904529A","b10","L3000-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","GSK1904529A (GSK 4529) is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM in cell-free assays, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.",851.96,"1089283-49-7",{"v":124,"d":"124.00"},145.55,"<1","N/A","http://selleckchem.com/products/GSK1904529A.html","C44H47F2N9O5S","free base","GSK 4529","CCC1=CC(=C(OC)C=C1N2CCC(CC2)N3CCN(CC3)[S](C)(=O)=O)NC4=NC(=CC=N4)C5=C(N=C6C=CC=C[N]56)C7=CC(=C(OC)C=C7)C(=O)NC8=C(F)C=CC=C8F",6.571,8,2,12]
["S1094","PF-04217903","c10","L3000-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1.",372.38,"956905-27-4",{"v":5,"d":"5.00"},13.43,"<1","N/A","http://selleckchem.com/products/PF-04217903.html","C19H16N8O","free base","N/A","OCC[N]1C=C(C=N1)C2=NC3=C(N=C2)N=N[N]3CC4=CC5=CC=CN=C5C=C4",1.561,6,1,5]
["S1095","Dacinostat (LAQ824)","d10","L3000-01","in 10mM DMSO","HDAC,p21","Epigenetics","Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.",379.46,"404951-53-7",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/LAQ824(NVP-LAQ824).html","C22H25N3O3","free base","NVP-LAQ824","OCCN(CCC1=C[NH]C2=C1C=CC=C2)CC3=CC=C(\\C=C\\C(=O)NO)C=C3",3.045,1,3,9]
["S1096","Quisinostat (JNJ-26481585) 2HCl","e10","L3000-01","in 10mM DMSO","HDAC","Epigenetics","Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.",467.39,"875320-31-3",{"v":79,"d":"79.00"},169.02,"<1","N/A","http://selleckchem.com/products/JNJ-26481585.html","C21H28Cl2N6O2","Dihydrochloride","N/A","Cl.Cl.C[N]1C=C(CNCC2CCN(CC2)C3=NC=C(C=N3)C(=O)NO)C4=CC=CC=C14",2.749,3,2,6]
["S1097","BTZ043 Racemate","f10","L3000-01","in 10mM DMSO","Bacterial","Microbiology","BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.",431.39,"957217-65-1",{"v":22,"d":"22.00"},{"v":51,"d":"51.00"},"<1","N/A","http://selleckchem.com/products/BTZ043.html","C17H16F3N3O5S","free base","N/A","CC1COC2(CCN(CC2)C3=NC(=O)C4=CC(=CC(=C4S3)[N+]([O-])=O)C(F)(F)F)O1",3.515,4,0,3]
["S1098","Rucaparib (AG-014699) phosphate","g10","L3000-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.",421.36,"459868-92-9",{"v":84,"d":"84.00"},199.35,"<1","N/A","http://selleckchem.com/products/AG-014699.html","C19H18FN3O.H3PO4","Phosphate","PF-01367338","CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)[NH]2)F.O[P](O)(O)=O",{"v":2.49,"d":"2.490"},1,3,3]
["S1100","MLN8054","h10","L3000-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.",476.86,"869363-13-3",{"v":95,"d":"95.00"},199.22,"<1","N/A","http://selleckchem.com/products/MLN8054.html","C25H15ClF2N4O2","free base","N/A","OC(=O)C1=CC=C(NC2=NC3=C(CN=C(C4=CC(=CC=C34)Cl)C5=C(F)C=CC=C5F)C=N2)C=C1",6.192,4,1,4]
["S1101","Vatalanib (PTK787) 2HCl","a11","L3000-01","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Vatalanib 2HCl (PTK787, ZK 222584, cpg-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM in a cell-free assay, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 3.",419.73,"212141-51-0",{"v":85,"d":"85.00"},202.51,{"v":10,"d":"10.00"},23.82,"http://selleckchem.com/products/Vatalanib,Dihydrochloride-Salt.html","C20H15ClN4.2HCl","Dihydrochloride","ZK 222584 (cpg-79787) 2HCl","Cl.Cl.ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C24)C=C1",5.469,3,1,4]
["S1102","U0126-EtOH","b11","L3000-01","in 10mM DMSO","Antiviral,Autophagy,MEK,Mitophagy","MAPK","U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.",426.56,"1173097-76-1",{"v":85,"d":"85.00"},199.27,"<1","N/A","http://selleckchem.com/products/U0126.html","C18H16N6S2.C2H6O","Ethanolate","N/A","CCO.N\\C(SC1=CC=CC=C1N)=C(C#N)\\C(C#N)=C(N)/SC2=CC=CC=C2N",2.169,0,5,5]
["S1103","ZM 447439","c11","L3000-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.",513.59,"331771-20-1",{"v":103,"d":"103.00"},200.55,"<1","N/A","http://selleckchem.com/products/ZM-447439.html","C29H31N5O4","free base","N/A","COC1=C(OCCCN2CCOCC2)C=C3N=CN=C(NC4=CC=C(NC(=O)C5=CC=CC=C5)C=C4)C3=C1",4.118,6,2,10]
["S1104","GDC-0879","d11","L3000-01","in 10mM DMSO","Raf","MAPK","GDC-0879 (AR-00341677) is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well; no inhibition known to other protein kinases.",334.37,"905281-76-7",{"v":66,"d":"66.00"},197.39,"<1","N/A","http://selleckchem.com/products/GDC-0879.html","C19H18N4O2","free base","AR-00341677","OCC[N]1C=C(C2=CC=C\\3C(=C2)CCC3=N\\O)C(=N1)C4=CC=NC=C4",2.387,3,1,4]
["S1105","LY294002","e11","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase,DNA-PK,PI3K","PI3K/Akt/mTOR","LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.",307.34,"154447-36-6",{"v":36,"d":"36.00"},117.13,"<1","N/A","http://selleckchem.com/products/LY294002.html","C19H17NO3","free base","SF 1101, NSC 697286","O=C1C=C(OC2=C(C=CC=C12)C3=CC=CC=C3)N4CCOCC4",3.342,3,0,2]
["S1106","OSU-03012 (AR-12)","f11","L3000-01","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.",460.45,"742112-33-0",{"v":11,"d":"11.00"},23.89,"<1","N/A","http://selleckchem.com/products/OSU-03012.html","C26H19F3N4O","free base","N/A","NCC(=O)NC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC4=C(C=C3)C5=C(C=CC=C5)C=C4)C(F)(F)F",5.212,2,2,5]
["S1107","Danusertib (PHA-739358)","g11","L3000-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,Bcr-Abl,c-RET,FGFR,Trk receptor","Cell Cycle","Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.",474.55,"827318-97-8",{"v":95,"d":"95.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHA-739358(Danusertib).html","C26H30N6O3","free base","N/A","COC(C(=O)N1CC2=C(C1)C(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CCN(C)CC4)C5=CC=CC=C5",2.337,4,2,6]
["S1109","BI 2536","h11","L3000-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Myc,PLK","Cell Cycle","BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.",521.66,"755038-02-9",{"v":21,"d":"21.00"},40.26,"<1","N/A","http://selleckchem.com/products/BI-2536.html","C28H39N7O3","free base","N/A","CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5",3.548,5,2,7]
["S1111","Foretinib (GSK1363089)","a2","L3000-02","in 10mM DMSO","c-Kit,c-Met,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Foretinib (GSK1363089, EXEL-2880, XL-880, GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.",632.65,"849217-64-7",{"v":100,"d":"100.00"},158.07,"<1","N/A","http://selleckchem.com/products/XL880(GSK1363089,EXEL-2880).html","C34H34F2N4O6","free base","EXEL-2880, XL-880, GSK089","COC1=CC2=C(C=C1OCCCN3CCOCC3)N=CC=C2OC4=C(F)C=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4",4.437,7,2,12]
["S1113","GSK690693","b2","L3000-02","in 10mM DMSO","Akt,AMPK,Autophagy,DAPK,PKA,PKC,STING,ULK","PI3K/Akt/mTOR","GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.",425.48,"937174-76-0",{"v":39,"d":"39.00"},91.66,"<1","N/A","http://selleckchem.com/products/GSK690693.html","C21H27N7O3","free base","N/A","CC[N]1C(=NC2=C1C(=CN=C2C#CC(C)(C)O)OCC3CCCNC3)C4=NON=C4N",1.839,6,2,7]
["S1114","JNJ-38877605","c2","L3000-02","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Phase 1.",377.35,"943540-75-8",{"v":37,"d":"37.00"},98.05,"<1","N/A","http://selleckchem.com/products/JNJ-38877605.html","C19H13F2N7","free base","N/A","C[N]1C=C(C=N1)C2=N[N]3C(=NN=C3C(F)(F)C4=CC5=C(C=C4)N=CC=C5)C=C2",3.052,5,0,3]
["S1115","Odanacatib (MK-0822)","d2","L3000-02","in 10mM DMSO","Cysteine Protease","Proteases","Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.",525.56,"603139-19-1",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/Odanacatib-(MK0822).html","C25H27F4N3O3S","free base","N/A","CC(C)(F)CC(NC(C1=CC=C(C=C1)C2=CC=C(C=C2)[S](C)(=O)=O)C(F)(F)F)C(=O)NC3(CC3)C#N",3.978,3,2,10]
["S1117","Triciribine (NSC 154020)","e2","L3000-02","in 10mM DMSO","Akt,DNA/RNA Synthesis,HIV","PI3K/Akt/mTOR","Triciribine (NSC 154020, VD-0002, vqd-002, API-2, TCN) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.",{"v":320.3,"d":"320.30"},"35943-35-2",{"v":64,"d":"64.00"},199.81,"<1","N/A","http://selleckchem.com/products/Triciribine.html","C13H16N6O4","free base","VD-0002, vqd-002, API-2, TCN","CN1N=C(N)C2=C[N](C3OC(CO)C(O)C3O)C4=C2C1=NC=N4",-1.119,4,4,2]
["S1119","Cabozantinib (BMS-907351)","f2","L3000-02","in 10mM DMSO","Apoptosis related,Axl,c-Met,VEGFR","Protein Tyrosine Kinase","Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.",501.51,"849217-68-1",{"v":100,"d":"100.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://selleckchem.com/products/XL184.html","C28H24FN3O5","Free Base","XL184,BMS-907351","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3",4.342,6,2,8]
["S1120","Everolimus (RAD001)","g2","L3000-02","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1","N/A","http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1121","TW-37","h2","L3000-02","in 10mM DMSO","Bcl-2","Apoptosis","TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.",{"v":573.7,"d":"573.70"},"877877-35-5",{"v":115,"d":"115.00"},200.45,"<1","N/A","http://selleckchem.com/products/TW-37.html","C33H35NO6S","free base","N/A","CC(C)C1=CC=CC=C1CC2=CC(=C(O)C(=C2O)O)C(=O)NC3=CC=C(C=C3)[S](=O)(=O)C4=C(C=CC=C4)C(C)(C)C",{"v":7.56,"d":"7.560"},3,4,8]
["S1122","Mocetinostat (MGCD0103)","a3","L3000-02","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.",396.44,"726169-73-9",{"v":13,"d":"13.00"},32.79,"<1","N/A","http://selleckchem.com/products/MGCD0103(Mocetinostat).html","C23H20N6O","free base","MG0103","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC3=NC=CC(=N3)C4=CC=CN=C4)C=C2",2.798,4,3,6]
["S1124","BMS-754807","b3","L3000-02","in 10mM DMSO","c-Met,IGF-1R,RON,Trk receptor","Protein Tyrosine Kinase","BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.",461.49,"1001350-96-4",{"v":92,"d":"92.00"},199.35,"<1","N/A","http://selleckchem.com/products/BMS-754807.html","C23H24FN9O","free base","N/A","CC1(CCCN1C2=N[N]3C=CC=C3C(=N2)NC4=N[NH]C(=C4)C5CC5)C(=O)NC6=CC=C(F)N=C6",4.069,5,3,6]
["S1129","SRT1720 HCl","c3","L3000-02","in 10mM DMSO","Autophagy,Sirtuin","Epigenetics","SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.",506.02,"1001645-58-4",{"v":38,"d":"38.00"},{"v":75.1,"d":"75.10"},"<1","N/A","http://selleckchem.com/products/SRT1720.html","C25H23N7OS.HCl","Hydrochloride","N/A","Cl.O=C(NC1=CC=CC=C1C2=C[N]3C(=CSC3=N2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5",3.018,4,2,5]
["S1130","Sepantronium Bromide","d3","L3000-02","in 10mM DMSO","Autophagy,IAP,Survivin","Apoptosis","Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.",443.29,"781661-94-7",{"v":55,"d":"55.00"},124.07,{"v":89,"d":"89.00"},200.77,"http://selleckchem.com/products/YM155.html","C20H19BrN4O3","Bromide","YM155","[Br-].COCC[N]1C(=[N+](CC2=CN=CC=N2)C3=C1C(=O)C4=C(C=CC=C4)C3=O)C",-0.733,5,0,5]
["S1132","3-Aminobenzamide","e3","L3000-02","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.",136.15,"3544-24-9",{"v":27,"d":"27.00"},198.31,"<1","N/A","https://www.selleckchem.com/products/3-aminobenzamide.html","C7H8N2O","free base","3-ABA , 3-amino Benzamide, 3-AB","NC(=O)C1=CC(=CC=C1)N",0.085,1,2,1]
["S1133","Alisertib (MLN8237)","f3","L3000-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy","Cell Cycle","Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.",518.92,"1028486-01-2",{"v":27,"d":"27.00"},52.03,"<1","N/A","http://selleckchem.com/products/MLN8237.html","C27H20ClFN4O4","free base","N/A","COC1=C(C(=CC=C1)F)C2=NCC3=C(N=C(NC4=CC(=C(C=C4)C(O)=O)OC)N=C3)C5=C2C=C(Cl)C=C5",5.954,6,1,6]
["S1134","AT9283","g3","L3000-02","in 10mM DMSO","Aurora Kinase,Bcr-Abl,JAK","JAK/STAT","AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I).",381.43,"896466-04-9",{"v":76,"d":"76.00"},199.25,"<1","N/A","http://selleckchem.com/products/AT9283.html","C19H23N7O2","free base","N/A","O=C(NC1CC1)NC2=C[NH]N=C2C3=NC4=CC(=CC=C4[NH]3)CN5CCOCC5",{"v":1.51,"d":"1.510"},4,4,5]
["S1137","Malotilate","h3","L3000-02","in 10mM DMSO","Lipoxygenase","Metabolism","Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.",288.38,"59937-28-9",{"v":58,"d":"58.00"},201.12,"<1","N/A","http://selleckchem.com/products/Malotilate.html","C12H16O4S2","free base","NKK105","CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1",2.363,4,0,6]
["S1138","Brivanib Alaninate (BMS-582664)","a4","L3000-02","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.",441.46,"649735-63-7",{"v":88,"d":"88.00"},199.34,"<1","N/A","http://selleckchem.com/products/Brivanib-alaninate.html","C22H24FN5O4","Alaninate","N/A","CC(N)C(=O)OC(C)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.383,6,2,8]
["S1141","Tanespimycin (17-AAG)","b4","L3000-02","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),Mitophagy","Cytoskeletal Signaling","Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.",585.69,"75747-14-7",{"v":100,"d":"100.00"},170.74,"<1","N/A","http://selleckchem.com/products/17-AAG(Geldanamycin).html","C31H43N3O8","free base","CP127374, NSC-330507, KOS 953","COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.524,7,4,7]
["S1142","Alvespimycin (17-DMAG) HCl","c4","L3000-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay.",653.21,"467214-21-7",{"v":131,"d":"131.00"},200.55,"<1","N/A","http://selleckchem.com/products/17-DMAG,Hydrochloride-Salt.html","C32H48N4O8.HCl","Hydrochloride","NSC 707545,BMS 826476 HCl,KOS 1022","Cl.COC1CC(C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.428,7,4,8]
["S1143","AG-490 (Tyrphostin B42)","d4","L3000-02","in 10mM DMSO","EGFR,JAK","Protein Tyrosine Kinase","AG-490 (Tyrphostin B42, Zinc02557947) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.",{"v":294.3,"d":"294.30"},"133550-30-8",{"v":58,"d":"58.00"},197.08,"<1","N/A","http://selleckchem.com/products/AG-490.html","C17H14N2O3","free base","Zinc02557947","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NCC2=CC=CC=C2",2.444,1,3,4]
["S1144","Ivacaftor (VX-770)","e4","L3000-02","in 10mM DMSO","CFTR","Transmembrane Transporters","Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.",392.49,"873054-44-5",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/VX-770.html","C24H28N2O3","free base","VX-770","CC(C)(C)C1=CC(=C(NC(=O)C2=CNC3=C(C=CC=C3)C2=O)C=C1O)C(C)(C)C",4.516,2,3,4]
["S1145","SNS-032 (BMS-387032)","f4","L3000-02","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.",380.53,"345627-80-7",{"v":76,"d":"76.00"},199.72,"<1","N/A","http://selleckchem.com/products/SNS-032.html","C17H24N4O2S2","free base","N/A","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1",{"v":2.07,"d":"2.070"},4,2,6]
["S1147","Barasertib (AZD1152-HQPA)","g4","L3000-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.",507.56,"722544-51-6",{"v":102,"d":"102.00"},200.96,"<1","N/A","http://selleckchem.com/products/AZD1152-HQPA.html","C26H30FN7O3","free base","AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib","CCN(CCO)CCCOC1=CC=C2C(=NC=NC2=C1)NC3=CC(=N[NH]3)CC(=O)NC4=CC=CC(=C4)F",3.493,5,4,13]
["S1148","Docetaxel (RP56976)","h4","L3000-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",807.88,"114977-28-5",{"v":100,"d":"100.00"},123.78,"<1","N/A","http://selleckchem.com/products/Docetaxel(Taxotere).html","C43H53NO14","Free Base","NSC 628503,RP56976","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",2.586,10,4,13]
["S1150","Paclitaxel (NSC 125973)","a5","L3000-02","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.",853.91,"33069-62-4",{"v":171,"d":"171.00"},200.26,"<1","N/A","http://selleckchem.com/products/Paclitaxel(Taxol).html","C47H51NO14","free base","PTX, Taxol, Onxal, Abraxane,NSC 125973","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S1152","PLX-4720","b5","L3000-02","in 10mM DMSO","Raf","MAPK","PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.",413.83,"918505-84-7",{"v":83,"d":"83.00"},200.57,"<1","N/A","http://selleckchem.com/products/PLX-4720.html","C17H14ClF2N3O3S","free base","N/A","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(Cl)C=C23",3.435,4,2,6]
["S1153","Roscovitine (CYC202)","c5","L3000-02","in 10mM DMSO","CDK","Cell Cycle","Roscovitine (CYC202, Seliciclib, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6. Phase 2.",354.45,"186692-46-6",{"v":71,"d":"71.00"},200.31,"<1","N/A","http://selleckchem.com/products/Roscovitine.html","C19H26N6O","free base","Seliciclib, R-roscovitine","CCC(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=CC=C3",{"v":3.32,"d":"3.320"},3,3,8]
["S1154","SNS-314","d5","L3000-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.",430.93,"1057249-41-8",{"v":105,"d":"105.00"},243.66,{"v":6,"d":"6.00"},13.92,"http://selleckchem.com/products/sns-314-mesylate.html","C18H15ClN6OS2","Mesylate","N/A","C[S](O)(=O)=O.ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.539,4,3,6]
["S1155","S3I-201","e5","L3000-02","in 10mM DMSO","STAT","JAK/STAT","S3I-201 (NSC 74859) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.",365.36,"501919-59-1",{"v":73,"d":"73.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/S31-201.html","C16H15NO7S","free base","NSC 74859","CC1=CC=C(C=C1)[S](=O)(=O)OCC(=O)NC2=CC=C(C(O)=O)C(=C2)O",1.712,3,2,6]
["S1156","Capecitabine (RO 09-1978)","f5","L3000-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis","DNA Damage/DNA Repair","Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.",359.35,"154361-50-9",{"v":72,"d":"72.00"},200.36,{"v":6,"d":"6.00"},{"v":16.7,"d":"16.70"},"http://selleckchem.com/products/Capecitabine(Xeloda).html","C15H22FN3O6","free base","RO 09-1978","CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2OC(C)C(O)C2O",{"v":0.82,"d":"0.820"},5,3,7]
["S1157","Delanzomib (CEP-18770)","g5","L3000-02","in 10mM DMSO","Proteasome","Proteases","Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2.",413.28,"847499-27-8",{"v":83,"d":"83.00"},200.83,"<1","N/A","http://selleckchem.com/products/cep-18770.html","C21H28BN3O5","free base","N/A","CC(C)C(CNC(=O)C(NC(=O)C1=NC(=CC=C1)C2=CC=CC=C2)C(C)O)B(O)O",2.646,3,3,9]
["S1158","MK-8245","h5","L3000-02","in 10mM DMSO","SCD","Metabolism","MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.",467.25,"1030612-90-8",{"v":93,"d":"93.00"},199.04,"<1","N/A","http://selleckchem.com/products/mk-8245.html","C17H16BrFN6O4","free base","N/A","OC(=O)C[N]1N=NC(=N1)C2=CC(=NO2)N3CCC(CC3)OC4=CC(=CC=C4Br)F",2.991,7,0,6]
["S1159","Ganetespib (STA-9090)","a6","L3000-02","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.",{"v":364.4,"d":"364.40"},"888216-25-9",{"v":40,"d":"40.00"},109.77,"<1","N/A","http://selleckchem.com/products/ganetespib-sta-9090.html","C20H20N4O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)[N](C)C=C4",3.866,2,3,3]
["S1162","Pretomanid (PA-824)","b6","L3000-02","in 10mM DMSO","Bacterial","Microbiology","PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.Phase 2.",359.26,"187235-37-6",{"v":72,"d":"72.00"},200.41,"<1","N/A","http://selleckchem.com/products/pa-824.html","C14H12F3N3O5","free base","N/A","[O-][N+](=O)C1=C[N]2CC(COC2=N1)OCC3=CC=C(OC(F)(F)F)C=C3",4.301,4,0,6]
["S1163","Onalespib (AT13387)","c6","L3000-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.",409.52,"912999-49-6",{"v":25,"d":"25.00"},61.05,"<1","N/A","http://selleckchem.com/products/at13387.html","C24H31N3O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C(=O)N2CC3=C(C2)C=C(CN4CCN(C)CC4)C=C3",3.322,1,2,4]
["S1164","Lenvatinib (E7080)","d6","L3000-02","in 10mM DMSO","c-Kit,c-RET,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Lenvatinib (E7080) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3.",426.85,"417716-92-8",{"v":40,"d":"40.00"},93.71,"<1","N/A","http://selleckchem.com/products/E7080.html","C21H19ClN4O4","free base","N/A","COC1=C(C=C2C(=CC=NC2=C1)OC3=CC(=C(NC(=O)NC4CC4)C=C3)Cl)C(N)=O",2.832,5,3,6]
["S1165","ABT-751 (E7010)","e6","L3000-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.",371.41,"141430-65-1",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/ABT-751.html","C18H17N3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(NC3=CC=C(O)C=C3)N=CC=C2",2.997,4,3,6]
["S1167","CP-724714","f6","L3000-02","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.",469.53,"537705-08-1",{"v":94,"d":"94.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://selleckchem.com/products/CP-724714.html","C27H27N5O3","free base","N/A","COCC(=O)NC/C=C/C1=CC=C2N=CN=C(NC3=CC=C(OC4=CC=C(C)N=C4)C(=C3)C)C2=C1",3.987,6,2,9]
["S1168","Valproic Acid (NSC 93819) sodium salt","g6","L3000-02","in 10mM DMSO","Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1α","Neuronal Signaling","Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.",166.19,"1069-66-5",{"v":33,"d":"33.00"},198.57,{"v":33,"d":"33.00"},198.57,"http://selleckchem.com/products/Sodium-valproate.html","C8H15NaO2","Sodium salt","Sodium valproate,NSC 93819,2-Propylpentanoic Acid","CCCC(CCC)C(=O)O[Na]",1.275,0,0,5]
["S1169","TGX-221","h6","L3000-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, 1000-fold more selective for p110β than p110α.",364.44,"663619-89-4",{"v":12,"d":"12.00"},32.93,"<1","N/A","http://selleckchem.com/products/TGX-221.html","C21H24N4O2","free base","N/A","CC(NC1=CC=CC=C1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.373,3,1,4]
["S1170","WZ3146","a7","L3000-02","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).",464.95,"1214265-56-1",{"v":93,"d":"93.00"},200.02,"<1","N/A","http://selleckchem.com/products/WZ3146.html","C24H25ClN6O2","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(Cl)C(=N3)OC4=CC(=CC=C4)NC(=O)C=C)C=C2",4.823,4,2,7]
["S1171","CYC116","b7","L3000-02","in 10mM DMSO","Aurora Kinase,VEGFR","Cell Cycle","CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.",368.46,"693228-63-6",{"v":24,"d":"24.00"},65.14,"<1","N/A","http://selleckchem.com/products/CYC116.html","C18H20N6OS","free base","N/A","CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.743,4,2,4]
["S1172","Serdemetan (JNJ-26854165)","c7","L3000-02","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1173","WZ4002","d7","L3000-02","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM in BaF3 cell line; does not inhibit ERBB2 phosphorylation (T798I).",494.18,"1213269-23-8",{"v":13,"d":"13.00"},26.31,"<1","N/A","http://selleckchem.com/products/WZ4002.html","C25H27ClN6O3","free base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)OC3=CC(=CC=C3)NC(=O)C=C)C=CC(=C1)N4CCN(C)CC4",4.807,5,2,8]
["S1175","BIIB021","e7","L3000-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.",318.76,"848695-25-0",{"v":64,"d":"64.00"},200.78,"<1","N/A","http://selleckchem.com/products/BIIB021.html","C14H15ClN6O","free base","CNF2024","COC1=C(C)C=NC(=C1C)C[N]2C=NC3=C(Cl)N=C(N)N=C23",2.223,5,1,3]
["S1176","Plinabulin (NPI-2358)","f7","L3000-02","in 10mM DMSO","Microtubule Associated,VDA","Angiogenesis","Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.",336.39,"714272-27-2",{"v":54,"d":"54.00"},160.53,"<1","N/A","http://selleckchem.com/products/NPI-2358.html","C19H20N4O2","free base","N/A","CC(C)(C)C1=C(/C=C/2NC(=O)C(/NC2=O)=C/C3=CC=CC=C3)N=C[NH]1",1.921,3,3,3]
["S1177","PD98059","g7","L3000-02","in 10mM DMSO","AhR,MEK","MAPK","PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.",267.28,"167869-21-8",{"v":14,"d":"14.00"},52.38,"<1","N/A","http://selleckchem.com/products/PD-98059.html","C16H13NO3","free base","N/A","COC1=C(N)C(=CC=C1)C2=CC(=O)C3=CC=CC=C3O2",2.373,3,1,2]
["S1178","Regorafenib (BAY 73-4506)","h7","L3000-02","in 10mM DMSO","Autophagy,c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY 73-4506,Fluoro-Sorafenib, Resihance, Stivarga) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.",482.82,"755037-03-7",{"v":97,"d":"97.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://selleckchem.com/products/BAY-73-4506.html","C21H15ClF4N4O3","free base","Fluoro-Sorafenib, Resihance, Stivarga,BAY 73-4506","CNC(=O)C1=CC(=CC=N1)OC2=CC(=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)F",4.381,4,3,6]
["S1179","WZ8040","a8","L3000-02","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).",481.01,"1214265-57-2",{"v":96,"d":"96.00"},199.58,"<1","N/A","http://selleckchem.com/products/WZ8040.html","C24H25ClN6OS","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(Cl)C(=N3)SC4=CC(=CC=C4)NC(=O)C=C)C=C2",5.381,3,2,7]
["S1180","XAV-939","b8","L3000-02","in 10mM DMSO","PARP,Wnt/beta-catenin","Stem Cells & Wnt","XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.",312.31,"284028-89-3",{"v":12,"d":"12.00"},38.42,"<1","N/A","http://selleckchem.com/products/XAV-939.html","C14H11F3N2OS","free base","NVP-XAV939","OC1=C2CSCCC2=NC(=N1)C3=CC=C(C=C3)C(F)(F)F",3.676,2,1,2]
["S1181","ENMD-2076","c8","L3000-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,CSF-1R,FGFR,FLT3,PDGFR,Src,VEGFR","Angiogenesis","ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.",375.47,"934353-76-1",{"v":105,"d":"105.00"},279.65,{"v":1,"d":"1.00"},2.66,"http://selleckchem.com/products/enmd-2076.html","C21H25N7","Tartaric Acid","N/A","CN1CCN(CC1)C2=CC(=NC(=N2)\\C=C\\C3=CC=CC=C3)NC4=N[NH]C(=C4)C",4.015,3,2,5]
["S1185","Ritonavir (ABT-538)","d8","L3000-02","in 10mM DMSO","Apoptosis related,COVID-19,HIV Protease,P450 (e.g. CYP17)","Proteases","Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.",720.94,"155213-67-5",{"v":100,"d":"100.00"},138.71,"<1","N/A","http://selleckchem.com/products/Ritonavir.html","C37H48N6O5S2","free base","ABT-538,A 84538, RTV, Norvir, Norvir Softgel","CC(C)C(NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)CC4=CC=CC=C4",4.978,6,4,18]
["S1186","BIBR 1532","e8","L3000-02","in 10mM DMSO","Apoptosis related,Telomerase","DNA Damage/DNA Repair","BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.",331.36,"321674-73-1",{"v":66,"d":"66.00"},199.18,"<1","N/A","http://selleckchem.com/products/BIBR1532.html","C21H17NO3","free base","N/A","CC(=C\\C(=O)NC1=C(C=CC=C1)C(O)=O)/C2=CC3=CC=CC=C3C=C2",4.067,2,1,4]
["S1188","Anastrozole (ZD-1033)","f8","L3000-02","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Anastrozole (Arimidex,ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.",293.37,"120511-73-1",{"v":59,"d":"59.00"},201.11,"<1","N/A","http://selleckchem.com/products/Anastrozole.html","C17H19N5","free base","Arimidex,ZD-1033","CC(C)(C#N)C1=CC(=CC(=C1)C[N]2C=NC=N2)C(C)(C)C#N",2.965,2,0,4]
["S1189","Aprepitant (MK-0869)","g8","L3000-02","in 10mM DMSO","CSF-1R,HIV,Interleukins,Neurokinin Receptor,TNF-alpha","Neuronal Signaling","Aprepitant (MK-0869, L-754030, Emend) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.",534.43,"170729-80-3",{"v":107,"d":"107.00"},200.21,"<1","N/A","http://selleckchem.com/products/Aprepitant.html","C23H21F7N4O3","free base","MK-0869, L-754030, Emend","CC(OC1OCCN(CC2=NNC(=O)N2)C1C3=CC=C(F)C=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",4.635,4,2,8]
["S1190","Bicalutamide (ICI-176334)","h8","L3000-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.",430.37,"90357-06-5",{"v":86,"d":"86.00"},199.83,"<1","N/A","http://selleckchem.com/products/Bicalutamide(Casodex).html","C18H14F4N2O4S","free base","ICI-176334","CC(O)(C[S](=O)(=O)C1=CC=C(F)C=C1)C(=O)NC2=CC=C(C#N)C(=C2)C(F)(F)F",2.926,3,1,6]
["S1191","Fulvestrant (ICI-182780)","a9","L3000-02","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor","Endocrinology & Hormones","Fulvestrant (ICI-182780, ZD 9238, ZM 182780) is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity.",606.77,"129453-61-8",{"v":100,"d":"100.00"},164.81,"<1","N/A","http://selleckchem.com/products/Fulvestrant.html","C32H47F5O3S","free base","ICI-182780, ZD 9238, ZM 182780","CC12CCC3C(C(CCCCCCCCC[S](=O)CCCC(F)(F)C(F)(F)F)CC4=C3C=CC(=C4)O)C1CCC2O",8.437,1,2,15]
["S1192","Raltitrexed","b9","L3000-02","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.",458.49,"112887-68-0",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/Raltitrexed.html","C21H22N4O6S","free base","ZD-1694, ICI-D1694, D1694","CN(CC1=CC2=C(C=C1)N=C(C)NC2=O)C3=CC=C(S3)C(=O)NC(CCC(O)=O)C(O)=O",1.528,5,2,9]
["S1193","Thalidomide (K17)","c9","L3000-02","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.",258.23,"50-35-1",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Thalidomide.html","C13H10N2O4","free base","K17","O=C1CCC(N2C(=O)C3=C(C=CC=C3)C2=O)C(=O)N1",0.097,4,1,1]
["S1194","CUDC-101","d9","L3000-02","in 10mM DMSO","EGFR,HDAC,HER2","Epigenetics","CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.",434.49,"1012054-59-9",{"v":20,"d":"20.00"},46.03,"<1","N/A","http://selleckchem.com/products/CUDC-101.html","C24H26N4O4","free base","N/A","COC1=CC2=C(C=C1OCCCCCCC(=O)NO)C(=NC=N2)NC3=CC(=CC=C3)C#C",5.376,5,2,11]
["S1195","Orteronel","e9","L3000-02","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Orteronel(TAK-700) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). TAK-700 (Orteronel) is an androgen biosynthesis inhibitor. Phase 3.",307.35,"426219-18-3",{"v":61,"d":"61.00"},198.47,"<1","N/A","http://selleckchem.com/products/TAK-700.html","C18H17N3O2","free base","TAK-700","CNC(=O)C1=CC=C2C=C(C=CC2=C1)C3(O)CC[N]4C=NC=C34",1.075,2,1,2]
["S1196","Exemestane (FCE 24304)","f9","L3000-02","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Exemestane (Aromasin,FCE24304, PNU155971,EXE) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.",{"v":296.4,"d":"296.40"},"107868-30-4",{"v":54,"d":"54.00"},182.19,"<1","N/A","http://selleckchem.com/products/Exemestane.html","C20H24O2","free base","Aromasin,FCE24304, PNU155971,EXE","CC12CCC3C(CC(=C)C4=CC(=O)C=CC34C)C1CCC2=O",3.606,2,0,0]
["S1197","Finasteride","g9","L3000-02","in 10mM DMSO","5-alpha Reductase","Endocrinology & Hormones","Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).",372.54,"98319-26-7",{"v":75,"d":"75.00"},201.32,"<1","N/A","http://selleckchem.com/products/Finasteride.html","C23H36N2O2","free base","MK-906","CC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C",3.174,2,2,2]
["S1199","Cladribine (RWJ 26251)","h9","L3000-02","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.",285.69,"4291-63-8",{"v":57,"d":"57.00"},199.52,"<1","N/A","http://selleckchem.com/products/Cladribine.html","C10H12ClN5O3","free base","Leustatin,2-CdA,2-Chloro-2′-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251","NC1=NC(=NC2=C1N=C[N]2C3CC(O)C(CO)O3)Cl",-0.259,4,3,2]
["S1200","Decitabine (NSC 127716)","a10","L3000-02","in 10mM DMSO","Apoptosis related,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","Epigenetics","Decitabine (Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.",228.21,"2353-33-5",{"v":45,"d":"45.00"},197.19,{"v":10,"d":"10.00"},43.82,"http://selleckchem.com/products/Decitabine.html","C8H12N4O4","free base","Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716","NC1=NC(=O)N(C=N1)C2CC(O)C(CO)O2",-1.093,4,3,2]
["S1201","Dimesna","b10","L3000-02","in 10mM DMSO","Others","Others","Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity.",326.34,"16208-51-8",{"v":65,"d":"65.00"},199.18,{"v":65,"d":"65.00"},199.18,"http://selleckchem.com/products/Dimesna.html","C4H8Na2O6S4","Disodium salt","BNP-7787","[Na+].[Na+].[O-][S](=O)(=O)CCSSCC[S]([O-])(=O)=O",-4.295,0,0,7]
["S1202","Dutasteride","c10","L3000-02","in 10mM DMSO","5-alpha Reductase","Endocrinology & Hormones","Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).",528.53,"164656-23-9",{"v":62,"d":"62.00"},117.31,"<1","N/A","http://selleckchem.com/products/Dutasteride.html","C27H30F6N2O2","free base","GI198745, GG-745","CC12CCC3C(CCC4NC(=O)C=CC34C)C1CCC2C(=O)NC5=CC(=CC=C5C(F)(F)F)C(F)(F)F",5.703,2,2,4]
["S1204","Melatonin (NSC 113928)","d10","L3000-02","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1","N/A","http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1206","Bisoprolol fumarate","e10","L3000-02","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker.",441.52,"104344-23-2",{"v":88,"d":"88.00"},199.31,{"v":88,"d":"88.00"},199.31,"http://selleckchem.com/products/Bisoprolol-Fumarate.html","C22H35NO8","fumarate","EMD33512","CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.OC(=O)\\C=C\\C(O)=O",-0.635,5,2,14]
["S1207","Tivozanib (AV-951)","f10","L3000-02","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Tivozanib (AV-951, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.",454.86,"475108-18-0",{"v":20,"d":"20.00"},43.97,"<1","N/A","http://selleckchem.com/products/AV-951.html","C22H19ClN4O5","free base","KRN-951","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)NC4=NOC(=C4)C)C(=C3)Cl",4.039,7,2,6]
["S1208","Doxorubicin (Adriamycin) HCl","g10","L3000-02","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1209","Fluorouracil (5-Fluorouracil, 5-FU)","h10","L3000-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,HIV,Nucleoside Analog/Antimetabolite,Thymidylate Synthase","DNA Damage/DNA Repair","Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.",130.08,"51-21-8",{"v":26,"d":"26.00"},199.88,"<1","N/A","http://selleckchem.com/products/Adrucil(Fluorouracil).html","C4H3FN2O2","free base","NSC 19893,5-Fluorouracil, 5-FU","FC1=CNC(=O)NC1=O",-1.102,2,2,0]
["S1210","Methotrexate (CL-14377)","a11","L3000-02","in 10mM DMSO","ADC Cytotoxin,DHFR","Metabolism","Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.",454.44,"59-05-2",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/Abitrexate.html","C20H22N8O5","free base","NCI-C04671, Amethopterin, CL14377, WR19039, abitrexate","CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",0.114,7,3,9]
["S1212","Bendamustine (SDX105) HCl","b11","L3000-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.",394.72,"3543-75-7",{"v":78,"d":"78.00"},197.61,{"v":2,"d":"2.00"},5.07,"http://selleckchem.com/products/Bendamustine-Hydrochloride.html","C16H21Cl2N3O2.HCl","Hydrochloride","Cytostasane HCl","Cl.C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCC(O)=O",3.988,2,0,9]
["S1213","Nelarabine","c11","L3000-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.",297.27,"121032-29-9",{"v":60,"d":"60.00"},201.84,{"v":3,"d":"3.00"},10.09,"http://selleckchem.com/products/Arranon.html","C11H15N5O5","free base","506U78,Arranon","COC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)N",-1.376,5,4,3]
["S1214","Bleomycin (NSC125066) sulfate","d11","L3000-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Bleomycin Sulfate (Blenoxane,NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.",1512.62,"9041-93-4",{"v":100,"d":"100.00"},{"v":66,"d":"66.00"},"N/A","N/A","http://www.selleckchem.com/products/Bleomycin-sulfate.html","C55H85N17O25S4","Sulfate","Blenoxane,NSC125066","CC(O)C(NC(=O)C(C)C(O)C(C)NC(=O)C(NC(=O)C1=C(C)C(=NC(=N1)C(CC(N)=O)NCC(N)C(N)=O)N)C(OC2OC(CO)C(O)C(O)C2OC3OC(CO)C(O)C(OC(N)=O)C3O)C4=C[NH]C=N4)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C.O[S]([O-])(=O)=O","N/A","N/A","N/A","N/A"]
["S1216","PFI-1 (PF-6405761)","e11","L3000-02","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-1 (PF-6405761) is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.",347.39,"1403764-72-6",{"v":69,"d":"69.00"},198.62,"<1","N/A","http://selleckchem.com/products/pfl-1.html","C16H17N3O4S","free base","N/A","COC1=C(C=CC=C1)[S](=O)(=O)NC2=CC=C3NC(=O)N(C)CC3=C2",1.376,4,2,4]
["S1218","Clofarabine","f11","L3000-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.",303.68,"123318-82-1",{"v":60,"d":"60.00"},197.58,"<1","N/A","http://selleckchem.com/products/Clofarabine.html","C10H11ClFN5O3","free base","Clolar","NC1=C2N=C[N](C3OC(CO)C(O)C3F)C2=NC(=N1)Cl",-0.085,4,3,2]
["S1219","YM201636","g11","L3000-02","in 10mM DMSO","Autophagy,PI3K,PIKfyve","PI3K/Akt/mTOR","YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue). YM-201636 suppresses the growth of liver cancer via the induction of autophagy.",467.48,"371942-69-7",{"v":35,"d":"35.00"},74.87,"<1","N/A","http://selleckchem.com/products/ym201636.html","C25H21N7O3","free base","N/A","NC1=CC=C(C=N1)C(=O)NC2=CC=CC(=C2)C3=NC(=C4OC5=NC=CC=C5C4=N3)N6CCOCC6",2.467,7,2,4]
["S1220","OSI-930","h11","L3000-02","in 10mM DMSO","c-Kit,CSF-1R,VEGFR","Protein Tyrosine Kinase","OSI-930 is a potent inhibitor of Kit (c-Kit), KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. Phase 1.",443.44,"728033-96-3",{"v":89,"d":"89.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/OSI-930.html","C22H16F3N3O2S","free base","N/A","FC(F)(F)OC1=CC=C(NC(=O)C2=C(NCC3=CC=NC4=CC=CC=C34)C=CS2)C=C1",6.266,3,2,7]
["S1221","Dacarbazine (NSC-45388)","a2","L3000-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.",182.18,"4342-03-4",{"v":12,"d":"12.00"},65.87,{"v":2,"d":"2.00"},10.98,"http://selleckchem.com/products/Dacarbazine.html","C6H10N6O","free base","DTIC-Dome, Imidazole Carboxamide,NSC-45388","CN(C)N=NC1=C(N=C[NH]1)C(N)=O",-0.344,4,2,3]
["S1222","Dexrazoxane HCl (ICRF-187)","b2","L3000-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Dexrazoxane HCl (ADR-529,Totect, ICRF-187, Zinecard, Cardioxane) is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent; also an inhibitor of topoisomerase II",304.73,"149003-01-0",{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},"http://selleckchem.com/products/Dexrazoxane-Hydrochloride.html","C11H16N4O4.HCl","Hydrochloride","ADR-529,Totect, ICRF-187, Zinecard, Cardioxane","Cl.CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-1.722,4,2,3]
["S1223","Epirubicin (IMI 28) HCl","c2","L3000-03","in 10mM DMSO","Apoptosis related,Topoisomerase","DNA Damage/DNA Repair","Epirubicin HCl (Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin induces apoptosis.",579.98,"56390-09-1",{"v":100,"d":"100.00"},172.42,{"v":100,"d":"100.00"},172.42,"http://selleckchem.com/products/Ellence.html","C27H29NO11.HCl","Hydrochloride","Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1225","Etoposide (VP-16)","d2","L3000-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II  inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.",588.56,"33419-42-0",{"v":100,"d":"100.00"},169.91,"<1","N/A","http://selleckchem.com/products/Etopophos.html","C29H32O13","free base","VP-16213,Vepesid,VP-16","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)C6=C2C=C7OCOC7=C6",0.935,10,3,5]
["S1226","KU-0063794","e2","L3000-03","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.",465.54,"938440-64-3",{"v":16,"d":"16.00"},34.37,"<1","N/A","http://selleckchem.com/products/KU-0063794.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=NC(=NC(=C3C=C2)N4CCOCC4)N5CC(C)OC(C)C5",3.274,6,1,5]
["S1227","Raloxifene HCl","f2","L3000-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (LY156758, Keoxifene) HCl is a selective and orally active estrogen receptor modulator (SERM), which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.",510.04,"82640-04-8",{"v":100,"d":"100.00"},196.06,"<1","N/A","http://selleckchem.com/products/Evista.html","C28H27NO4S.HCl","Hydrochloride","LY156758 (Keoxifene) HCl","Cl.OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.843,2,2,7]
["S1229","Fludarabine Phosphate","g2","L3000-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.",365.21,"75607-67-9",{"v":73,"d":"73.00"},199.88,{"v":2,"d":"2.00"},5.48,"http://selleckchem.com/products/Fludara.html","C10H13FN5O7P","Phosphate","F-ara-A (NSC 312887) Phosphate","NC1=NC(=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O)F",-1.384,5,3,4]
["S1230","Flavopiridol (L86-8275)","h2","L3000-03","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.",401.84,"146426-40-6",{"v":15,"d":"15.00"},37.33,"<1","N/A","http://selleckchem.com/products/Flavopiridol.html","C21H20ClNO5","Free Base","NSC 649890 HCl, HMR-1275, Alvocidib","CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",3.108,2,3,2]
["S1231","Topotecan (NSC609699) HCl","a3","L3000-03","in 10mM DMSO","Apoptosis related,Autophagy,Topoisomerase","DNA Damage/DNA Repair","Topotecan HCl (Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.",457.91,"119413-54-6",{"v":91,"d":"91.00"},198.73,{"v":91,"d":"91.00"},198.73,"http://selleckchem.com/products/Topotecan-Hydrochloride.html","C23H23N3O5.HCl","Hydrochloride","Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.959,4,1,3]
["S1233","2-Methoxyestradiol (2-MeOE2)","b3","L3000-03","in 10mM DMSO","Apoptosis related,Autophagy,HIF,Microtubule Associated","Angiogenesis","2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.",302.41,"362-07-2",{"v":60,"d":"60.00"},198.41,"<1","N/A","http://selleckchem.com/products/2-Methoxyestradiol(2ME2).html","C19H26O3","free base","NSC 659853, 2-ME2","COC1=C(O)C=C2CCC3C(CCC4(C)C(O)CCC34)C2=C1",3.821,1,2,1]
["S1234","AG-1024","c3","L3000-03","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","AG-1024 (Tyrphostin, AGS 200) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).",305.17,"65678-07-1",{"v":61,"d":"61.00"},199.89,"<1","N/A","http://selleckchem.com/products/ag-1024-tyrphostin.html","C14H13BrN2O","free base","Tyrphostin, AGS 200","CC(C)(C)C1=C(O)C(=CC(=C1)C=C(C#N)C#N)Br",3.922,0,1,2]
["S1235","Letrozole (CGS 20267)","d3","L3000-03","in 10mM DMSO","Aromatase,Autophagy","Endocrinology & Hormones","Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.",{"v":285.3,"d":"285.30"},"112809-51-5",{"v":57,"d":"57.00"},199.79,"<1","N/A","http://selleckchem.com/products/Letrozole.html","C17H11N5","free base","CGS 20267,Femara, Piroxicam","N#CC1=CC=C(C=C1)C([N]2C=NC=N2)C3=CC=C(C=C3)C#N",2.749,2,0,3]
["S1237","Temozolomide (CCRG 81045)","e3","L3000-03","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.",194.15,"85622-93-1",{"v":38,"d":"38.00"},195.72,"<1","N/A","http://selleckchem.com/products/Methazolastone.html","C6H6N6O2","free base","NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal","CN1N=NC2=C(N=C[N]2C1=O)C(N)=O",0.052,5,1,1]
["S1238","Tamoxifen (ICI 46474)","f3","L3000-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,ATPase,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Angiogenesis","Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.",371.51,"10540-29-1",{"v":74,"d":"74.00"},199.19,"<1","N/A","http://selleckchem.com/products/Nolvadex.html","C26H29NO","Free Base","ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1241","Vincristine (NSC-67574) sulfate","g3","L3000-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.",923.04,"2068-78-2",{"v":100,"d":"100.00"},108.34,{"v":60,"d":"60.00"},{"v":65,"d":"65.00"},"http://selleckchem.com/products/Vincristine-Sulfate.html","C46H58N4O14S","free base","Leurocristine, Oncovin, NSC-67574, 22-Oxovincaleukoblastine","CCC1(O)CC2CN(CCC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=CC6=C(C=C5OC)N(C=O)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC67C89)C(=O)OC)C1.O[S](O)(=O)=O",3.365,8,1,10]
["S1243","Agomelatine (S20098)","h3","L3000-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Agomelatine (Valdoxan, Melitor, Thymanax,S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.",{"v":243.3,"d":"243.30"},"138112-76-2",{"v":48,"d":"48.00"},197.29,"<1","N/A","http://selleckchem.com/products/Agomelatine.html","C15H17NO2","free base","Valdoxan, Melitor, Thymanax,S20098","COC1=CC2=C(CCNC(C)=O)C=CC=C2C=C1",{"v":2.17,"d":"2.170"},2,1,4]
["S1244","Amuvatinib (MP-470)","a4","L3000-03","in 10mM DMSO","Apoptosis related,c-Kit,c-Met,c-RET,FLT3,PDGFR,RAD51","Protein Tyrosine Kinase","Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.",447.51,"850879-09-3",{"v":32,"d":"32.00"},71.51,"<1","N/A","http://selleckchem.com/products/MP-470.html","C23H21N5O3S","free base","HPK 56","S=C(NCC1=CC=C2OCOC2=C1)N3CCN(CC3)C4=NC=NC5=C4OC6=CC=CC=C56",4.867,5,1,5]
["S1245","Latrepirdine 2HCl","b4","L3000-03","in 10mM DMSO","5-HT Receptor,GluR,Histamine Receptor","Neuronal Signaling","Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.",392.37,"97657-92-6",{"v":24,"d":"24.00"},61.17,"<1","N/A","http://selleckchem.com/products/Dimebon.html","C21H25N3.2HCl","Dihydrochloride","N/A","Cl.Cl.CN1CCC2=C(C1)C3=C(C=CC(=C3)C)[N]2CCC4=CC=C(C)N=C4",4.769,1,0,3]
["S1247","Leflunomide (HWA486)","c4","L3000-03","in 10mM DMSO","AhR,Dehydrogenase","Metabolism","Leflunomide (HWA486, RS-34821, SU101, Arava) is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of Leflunomide is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). Leflunomide is also an agonist of the AhR.",270.21,"75706-12-6",{"v":54,"d":"54.00"},199.84,"<1","N/A","http://selleckchem.com/products/Leflunomide.html","C12H9F3N2O2","free base","HWA486, RS-34821, SU101, Arava","CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F",2.156,3,1,3]
["S1249","JNJ-7706621","d4","L3000-03","in 10mM DMSO","Aurora Kinase,CDK","Cell Cycle","JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.",394.36,"443797-96-4",{"v":79,"d":"79.00"},200.32,"<1","N/A","http://selleckchem.com/products/JNJ-7706621.html","C15H12F2N6O3S","free base","N/A","NC1=NC(=N[N]1C(=O)C2=C(F)C=CC=C2F)NC3=CC=C(C=C3)[S](N)(=O)=O",2.226,5,3,4]
["S1250","Enzalutamide (MDV3100)","e4","L3000-03","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. Enzalutamide is shown to increase autophagy.",464.44,"915087-33-1",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/MDV3100.html","C21H16F4N4O2S","free base","MDV3100","CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC=C(C#N)C(=C3)C(F)(F)F",4.954,2,1,4]
["S1251","Dienogest","f4","L3000-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.",311.42,"65928-58-7",{"v":62,"d":"62.00"},199.09,"<1","N/A","http://selleckchem.com/products/Dienogest.html","C20H25NO2","free base","STS 557","CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC#N",3.046,1,0,1]
["S1255","Nepafenac","g4","L3000-03","in 10mM DMSO","COX","Neuronal Signaling","Nepafenac (AHR 9434, AL 6515) is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.",254.28,"78281-72-8",{"v":50,"d":"50.00"},196.63,"<1","N/A","http://selleckchem.com/products/Nepafenac.html","C15H14N2O2","free base","AHR 9434, AL 6515","NC(=O)CC1=CC=CC(=C1N)C(=O)C2=CC=CC=C2",1.524,2,2,4]
["S1257","Posaconazole (SCH 56592)","h4","L3000-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Posaconazole (SCH 56592,POS,Noxafil) is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.",700.78,"171228-49-2",{"v":100,"d":"100.00"},{"v":142.7,"d":"142.70"},"<1","N/A","http://selleckchem.com/products/Posaconazole.html","C37H42F2N8O4","free base","SCH 56592,POS,Noxafil","CCC(C(C)O)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C5)(C[N]6C=NC=N6)C7=CC=C(F)C=C7F)C=C4",5.096,6,1,12]
["S1259","Ramelteon","a5","L3000-03","in 10mM DMSO","MT Receptor","GPCR & G Protein","Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.",259.34,"196597-26-9",{"v":52,"d":"52.00"},200.51,"<1","N/A","http://selleckchem.com/products/Ramelteon.html","C16H21NO2","free base","TAK-375","CCC(=O)NCCC1CCC2=CC=C3OCCC3=C12",2.826,2,1,4]
["S1260","Cinacalcet (AMG-073) HCl","b5","L3000-03","in 10mM DMSO","CaSR","GPCR & G Protein","Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.",393.87,"364782-34-3",{"v":79,"d":"79.00"},200.57,"<1","N/A","http://selleckchem.com/products/Cinacalcet-hydrochloride.html","C22H22F3N.HCl","Hydrochloride","Mimpara, Sensipar,AMG-073","Cl.CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=C2C=CC=C3",6.338,0,1,7]
["S1261","Celecoxib (SC 58635)","c5","L3000-03","in 10mM DMSO","COX","Neuronal Signaling","Celecoxib (Celebrex, Celebra,SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.",381.37,"169590-42-5",{"v":76,"d":"76.00"},199.28,"<1","N/A","http://selleckchem.com/products/Celecoxib.html","C17H14F3N3O2S","free base","Celebrex, Celebra,SC 58635","CC1=CC=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)(F)F",4.428,3,1,4]
["S1262","Avagacestat (BMS-708163)","d5","L3000-03","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.",520.88,"1146699-66-2",{"v":104,"d":"104.00"},199.66,"<1","N/A","http://selleckchem.com/products/BMS-708163.html","C20H17ClF4N4O4S","free base","N/A","NC(=O)C(CCC(F)(F)F)N(CC1=C(F)C=C(C=C1)C2=NOC=N2)[S](=O)(=O)C3=CC=C(Cl)C=C3",3.364,6,1,10]
["S1263","Laduviglusib (CHIR-99021)","e5","L3000-03","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.",465.34,"252917-06-9",{"v":10,"d":"10.00"},21.49,"<1","N/A","http://selleckchem.com/products/CHIR-99021.html","C22H18Cl2N8","free base","CT99021","CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=CC=C(C=N3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.476,4,3,7]
["S1264","PD173074","f5","L3000-03","in 10mM DMSO","Apoptosis related,FGFR,VEGFR","Angiogenesis","PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.",523.67,"219580-11-7",{"v":100,"d":"100.00"},190.96,"<1","N/A","http://selleckchem.com/products/PD-173074.html","C28H41N7O3","free base","N/A","CCN(CC)CCCCNC1=NC=C2C=C(C(=NC2=N1)NC(=O)NC(C)(C)C)C3=CC(=CC(=C3)OC)OC",4.313,6,3,13]
["S1266","WYE-354","g5","L3000-03","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",495.53,"1062169-56-5",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/WYE-354.html","C24H29N7O5","free base","N/A","COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5",1.886,8,1,6]
["S1267","Vemurafenib (PLX4032)","h5","L3000-03","in 10mM DMSO","Autophagy,Raf","MAPK","Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.",489.92,"918504-65-1",{"v":97,"d":"97.00"},197.99,"<1","N/A","http://selleckchem.com/products/PLX-4032.html","C23H18ClF2N3O3S","free base","RG7204, RO5185426,PLX4032","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CC=C(Cl)C=C4",4.953,4,2,7]
["S1271","Acarbose","a6","L3000-03","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.",{"v":645.6,"d":"645.60"},"56180-94-0",{"v":100,"d":"100.00"},154.89,{"v":100,"d":"100.00"},154.89,"http://selleckchem.com/products/Acarbose.html","C25H43NO18","free base","BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421","CC1OC(OC2C(O)C(O)C(OC2CO)OC3C(O)C(O)C(O)OC3CO)C(O)C(O)C1NC4C=C(CO)C(O)C(O)C4O",-6.839,5,13,9]
["S1274","BX-795","b6","L3000-03","in 10mM DMSO","Autophagy,IκB/IKK,PDPK1,TBK1","PI3K/Akt/mTOR","BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.",591.47,"702675-74-9",{"v":100,"d":"100.00"},169.07,"<1","N/A","http://selleckchem.com/products/bx-795.html","C23H26IN7O2S","free base","N/A","IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4",3.704,4,4,9]
["S1275","BX-912","c6","L3000-03","in 10mM DMSO","PDK","PI3K/Akt/mTOR","BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.",471.35,"702674-56-4",{"v":94,"d":"94.00"},199.43,"<1","N/A","http://selleckchem.com/products/bx-912.html","C20H23BrN8O","free base","N/A","BrC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCC4=CN=C[NH]4",2.798,4,4,7]
["S1276","Adapalene","d6","L3000-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.",412.52,"106685-40-9",{"v":8,"d":"8.00"},19.39,"<1","N/A","http://selleckchem.com/products/Adapalene.html","C28H28O3","free base","CD-271","COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(O)=O)[C]45CC6[CH2][CH](C[CH]([CH2]6)C4)C5",6.279,2,0,4]
["S1278","Altretamine","e6","L3000-03","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.",210.28,"645-05-6",{"v":15,"d":"15.00"},71.33,"<1","N/A","http://selleckchem.com/products/Altretamine.html","C9H18N6","free base","Hexamethylmelamine, NSC13875, ENT50852","CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C",1.995,3,0,3]
["S1280","Amisulpride","f6","L3000-03","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.",369.48,"71675-85-9",{"v":73,"d":"73.00"},197.57,"<1","N/A","http://selleckchem.com/products/Amisulpride.html","C17H27N3O4S","free base","DAN-2163","CCN1CCCC1CNC(=O)C2=CC(=C(N)C=C2OC)[S](=O)(=O)CC",1.127,4,2,7]
["S1281","Aniracetam","g6","L3000-03","in 10mM DMSO","AMPA Receptor-kainate Receptor-NMDA Receptor","Neuronal Signaling","Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug.",219.24,"72432-10-1",{"v":44,"d":"44.00"},200.69,"<1","N/A","http://selleckchem.com/products/Aniracetam.html","C12H13NO3","free base","RO 13-5057","COC1=CC=C(C=C1)C(=O)N2CCCC2=O",1.267,3,0,2]
["S1282","Artemisinin","h6","L3000-03","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.",282.33,"63968-64-9",{"v":57,"d":"57.00"},201.89,"<1","N/A","http://selleckchem.com/products/Artemisinin.html","C15H22O5","free base","Qinghaosu,Artemisinine,Coartem,NSC 369397","CC1CCC2C(C)C(=O)OC3OC4(C)CCC1C23OO4",1.998,5,0,0]
["S1283","Asenapine maleate","a7","L3000-03","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor","Neuronal Signaling","Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.",401.84,"85650-56-2",{"v":80,"d":"80.00"},199.08,"<1","N/A","http://selleckchem.com/products/Asenapine.html","C17H16ClNO.C4H4O4","Maleate","Org 5222","CN1CC2C(C1)C3=C(OC4=C2C=CC=C4)C=CC(=C3)Cl.OC(=O)\\C=C/C(O)=O",0.883,3,0,2]
["S1284","Benazepril HCl","b7","L3000-03","in 10mM DMSO","RAAS","Endocrinology & Hormones","Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.",460.95,"86541-74-4",{"v":92,"d":"92.00"},199.59,{"v":19,"d":"19.00"},41.22,"http://selleckchem.com/products/Benazepril-hydrochloride.html","C24H28N2O5.HCl","Hydrochloride","CGS 14824A HCl","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=C(C=CC=C3)N(CC(O)=O)C2=O",1.003,4,1,10]
["S1287","Bumetanide","c7","L3000-03","in 10mM DMSO","NKCC","Transmembrane Transporters","Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.",364.42,"28395-03-1",{"v":73,"d":"73.00"},200.32,"<1","N/A","http://selleckchem.com/products/Bumetanide.html","C17H20N2O5S","free base","N/A","CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)[S](N)(=O)=O",2.862,4,2,8]
["S1289","Carmofur","d7","L3000-03","in 10mM DMSO","COVID-19,DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.",257.26,"61422-45-5",{"v":52,"d":"52.00"},202.13,"<1","N/A","http://selleckchem.com/products/Carmofur.html","C11H16FN3O3","free base","HCFU","CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O",1.125,3,2,5]
["S1290","Celastrol (NSC 70931)","e7","L3000-03","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1291","Cetirizine DiHCl","f7","L3000-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cetirizine DiHCl (Zyrtec, Reactine,UCB P071) is an antihistamine.",461.81,"83881-52-1",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/Cetirizine-Dihydrochloride.html","C21H25ClN2O3.2HCl","Dihydrochloride","Zyrtec, Reactine,UCB P071","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S1292","Chelerythrine Chloride (NSC 646662)","g7","L3000-03","in 10mM DMSO","PKC","TGF-beta/Smad","Chelerythrine Chloride (NSC 646662, Broussonpapyrine) is a potent, selective antagonist of PKC with IC50 of 0.66 μM.",384.83,"3895-92-9",{"v":4,"d":"4.00"},10.39,"<1","N/A","http://www.selleck.cn/products/Chelerythrine-chloride.html","C21H18NO4.HCl","Chloride","Broussonpapyrine chloride","Cl.COC1=CC=C2C(=C1OC)C=[N+](C)C3=C2C=CC4=C3C=C5OCOC5=C4",4.568,4,0,2]
["S1294","Cilostazol (OPC-13013)","h7","L3000-03","in 10mM DMSO","PDE","Metabolism","Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.",369.46,"73963-72-1",{"v":74,"d":"74.00"},200.29,"<1","N/A","http://selleckchem.com/products/Cilostazol.html","C20H27N5O2","free base","Pletal,OPC-13013","O=C1CCC2=C(N1)C=CC(=C2)OCCCCC3=NN=N[N]3C4CCCCC4",{"v":3.23,"d":"3.230"},5,1,7]
["S1297","Epothilone A","a8","L3000-03","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.",493.66,"152044-53-6",{"v":99,"d":"99.00"},200.54,"<1","N/A","http://selleckchem.com/products/Epothilone-A.html","C26H39NO6S","free base","N/A","CC1CCCC2OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.574,5,2,2]
["S1299","Floxuridine (NSC 27640)","b8","L3000-03","in 10mM DMSO","Apoptosis related,CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.",246.19,"50-91-9",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/Floxuridine.html","C9H11FN2O5","free base","Deoxyfluorouridine, FUDR,NSC 27640","OCC1OC(CC1O)N2C=C(F)C(=O)NC2=O",-1.775,3,3,2]
["S1300","Tegafur (FT-207)","c8","L3000-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.",200.17,"17902-23-7",{"v":40,"d":"40.00"},199.83,{"v":8,"d":"8.00"},39.97,"http://selleckchem.com/products/Ftorafur.html","C8H9FN2O3","free base","NSC 148958,Fluorafur,FT-207","FC1=CN(C2CCCO2)C(=O)NC1=O",-0.625,3,1,1]
["S1302","Ifosfamide (NSC109724)","d8","L3000-03","in 10mM DMSO","DNA alkylator,DNA/RNA Synthesis","DNA Damage/DNA Repair","Ifosfamide (Mitoxana, Ifex,Isophosphamide,NSC109724) is a nitrogen mustard alkylating agent used in the treatment of cancer.",261.09,"3778-73-2",{"v":52,"d":"52.00"},199.17,{"v":52,"d":"52.00"},199.17,"http://selleckchem.com/products/Ifosfamide.html","C7H15Cl2N2O2P","free base","Mitoxana, Ifex,Isophosphamide,NSC109724","ClCCN[P]1(=O)OCCCN1CCCl",0.144,2,1,5]
["S1304","Megestrol Acetate","e8","L3000-03","in 10mM DMSO","Androgen Receptor,Estrogen/progestogen Receptor","Endocrinology & Hormones","Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.",384.51,"595-33-5",{"v":33,"d":"33.00"},85.82,"<1","N/A","http://selleckchem.com/products/Megestrol-Acetate.html","C24H32O4","free base","BDH1298, SC10363","CC(=O)OC1(CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C)C(C)=O",3.505,4,0,3]
["S1305","Mercaptopurine (6-MP)","f8","L3000-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",152.18,"50-44-2",{"v":30,"d":"30.00"},197.13,"<1","N/A","http://selleckchem.com/products/Mercaptopurine.html","C5H4N4S","free base","6-MP","S=C1N=CNC2=C1[NH]C=N2",0.367,2,2,0]
["S1315","Ki16425","g8","L3000-03","in 10mM DMSO","LPA Receptor","GPCR & G Protein","Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively, shows no activity at LPA4, LPA5, LPA6.",474.96,"355025-24-0",{"v":94,"d":"94.00"},197.91,"<1","N/A","http://selleckchem.com/products/Ki16425.html","C23H23ClN2O5S","free base","N/A","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(CSCCC(O)=O)C=C2)C3=C(Cl)C=CC=C3",5.043,5,1,10]
["S1319","Costunolide","h8","L3000-03","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.",232.32,"553-21-9",{"v":47,"d":"47.00"},202.31,"<1","N/A","http://selleckchem.com/products/Costunolide.html","C15H20O2","free base","NSC 106404","CC/1=C\\CC\\C(=C\\C2OC(=O)C(=C)C2CC1)C",4.022,2,0,0]
["S1322","Dexamethasone (MK-125)","a9","L3000-03","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1324","Doxazosin Mesylate","b9","L3000-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.",547.58,"77883-43-3",{"v":15,"d":"15.00"},27.39,"<1","N/A","http://selleckchem.com/products/Doxazosin-mesylate.html","C23H25N5O5.CH4O3S","Mesylate","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCN(CC3)C(=O)C4COC5=C(O4)C=CC=C5)N.C[S](O)(=O)=O",2.071,7,1,4]
["S1326","Edaravone","c9","L3000-03","in 10mM DMSO","Antioxidant","ER stress & UPR","Edaravone (MCI-186) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.",{"v":174.2,"d":"174.20"},"89-25-8",{"v":35,"d":"35.00"},200.92,"<1","N/A","http://selleckchem.com/products/Edaravone.html","C10H10N2O","free base","MCI-186","CC1=NN(C(=O)C1)C2=CC=CC=C2",1.123,2,0,1]
["S1328","Etodolac","d9","L3000-03","in 10mM DMSO","COX","Neuronal Signaling","Etodolac(AY-24236) is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.",287.35,"41340-25-4",{"v":58,"d":"58.00"},201.84,"<1","N/A","http://selleckchem.com/products/Etodolac.html","C17H21NO3","free base","AY-24236","CCC1=CC=CC2=C1[NH]C3=C2CCOC3(CC)CC(O)=O",3.723,2,1,4]
["S1330","Felbamate","e9","L3000-03","in 10mM DMSO","NMDAR","Neuronal Signaling","Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.",238.24,"25451-15-4",{"v":48,"d":"48.00"},201.48,"<1","N/A","http://selleckchem.com/products/Felbamate.html","C11H14N2O4","free base","Felbatol, ADD-03055,W-554","NC(=O)OCC(COC(N)=O)C1=CC=CC=C1",0.984,4,2,7]
["S1331","Fluconazole (UK 49858)","f9","L3000-03","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Fluconazole (Diflucan, Trican, Alfumet,UK 49858) is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.",306.27,"86386-73-4",{"v":61,"d":"61.00"},199.17,"<1","N/A","http://selleckchem.com/products/Fluconazole.html","C13H12F2N6O","free base","Diflucan, Trican, Alfumet,UK 49858","OC(C[N]1C=NC=N1)(C[N]2C=NC=N2)C3=C(F)C=C(F)C=C3",{"v":0.75,"d":"0.750"},4,0,5]
["S1332","Flumazenil (RO 15-1788)","g9","L3000-03","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.",303.29,"78755-81-4",{"v":5,"d":"5.00"},16.49,"<1","N/A","http://selleckchem.com/products/Flumazenil.html","C15H14FN3O3","free base","RO 15-1788","CCOC(=O)C1=C2CN(C)C(=O)C3=CC(=CC=C3[N]2C=N1)F",1.583,4,0,3]
["S1333","Fluoxetine (Lilly 110140) HCl","h9","L3000-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.",345.79,"56296-78-7",{"v":69,"d":"69.00"},199.54,{"v":4,"d":"4.00"},11.57,"http://selleckchem.com/products/Fluoxetine-hydrochloride.html","C17H18F3NO.HCl","Hydrochloride","Prozac, Sarafem,LY-110140","Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2",4.415,1,1,7]
["S1334","Flupirtine maleate","a10","L3000-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.",420.39,"75507-68-5",{"v":84,"d":"84.00"},199.81,"<1","N/A","http://selleckchem.com/products/Flupirtine-maleate.html","C15H17FN4O2.C4H4O4","Maleate","N/A","CCOC(=O)NC1=C(N)N=C(NCC2=CC=C(F)C=C2)C=C1.OC(=O)\\C=C\\C(O)=O",{"v":2.76,"d":"2.760"},5,3,8]
["S1336","Fluvoxamine (DU-23000) maleate","b10","L3000-03","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.",434.41,"61718-82-9",{"v":87,"d":"87.00"},200.27,"<1","N/A","http://selleckchem.com/products/Fluvoxamine-maleate.html","C19H25F3N2O6","Maleate","MK-264,DU-23000 maleate","COCCCCC(=N\\OCCN)/C1=CC=C(C=C1)C(F)(F)F.OC(=O)\\C=C/C(O)=O",0.111,5,1,12]
["S1340","Gatifloxacin","c10","L3000-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Gatifloxacin (AM-1155, CG5501, BMS-206584) is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.",375.39,"112811-59-3",{"v":7,"d":"7.00"},18.65,"<1","N/A","http://selleckchem.com/products/Gatifloxacin.html","C19H22FN3O4","free base","AM-1155, CG5501, BMS-206584","COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CCNC(C)C3)F)C4CC4",-0.909,3,1,4]
["S1342","Genistein (NPI 031L)","d10","L3000-03","in 10mM DMSO","EGFR,Topoisomerase","Protein Tyrosine Kinase","Genistein (NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK)  which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.",270.24,"446-72-0",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Genistein.html","C15H10O5","free base","NPI 031L","OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O",{"v":2.14,"d":"2.140"},2,3,1]
["S1343","Ginkgolide B","e10","L3000-03","in 10mM DMSO","PAFR","GPCR & G Protein","Ginkgolide B (BN52021) is a PAFR antagonist with IC50 of 3.6 μM.",{"v":424.4,"d":"424.40"},"15291-77-7",{"v":85,"d":"85.00"},200.28,"<1","N/A","http://selleckchem.com/products/Ginkgolide-B.html","C20H24O10","free base","BN52021","CC1C(=O)OC2C(O)C34C5CC(C(C)(C)C)C36C(O)C(=O)OC6OC4(C(=O)O5)C12O",-0.854,7,2,1]
["S1344","Glimepiride","f10","L3000-03","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glimepiride(HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.",490.62,"93479-97-1",{"v":11,"d":"11.00"},22.42,"<1","N/A","http://selleckchem.com/products/Glimepiride.html","C24H34N4O5S","free base","HOE-490","CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCC(C)CC3)C1=O",3.781,5,3,7]
["S1351","Ivermectin (MK-933)","g10","L3000-03","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1","N/A","http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1352","TG100-115","h10","L3000-03","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.",346.34,"677297-51-7",{"v":9,"d":"9.00"},25.99,"<1","N/A","http://selleckchem.com/products/TG100-115.html","C18H14N6O2","free base","N/A","NC1=NC2=NC(=C(N=C2C(=N1)N)C3=CC(=CC=C3)O)C4=CC=CC(=C4)O",2.687,4,4,2]
["S1354","Lansoprazole","a11","L3000-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.",369.36,"103577-45-3",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/Lansoprazole.html","C16H14F3N3O2S","free base","A-65006, AG-1749","CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2",3.442,4,1,6]
["S1357","Lidocaine","b11","L3000-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.",234.34,"137-58-6",{"v":47,"d":"47.00"},200.56,{"v":9,"d":"9.00"},38.41,"http://selleckchem.com/products/Lidocaine.html","C14H22N2O","Free Base","Alphacaine","CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",2.626,1,1,5]
["S1358","Loratadine (SCH29851)","c11","L3000-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Loratadine (Alavert,Claritin,SCH29851) is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.",382.88,"79794-75-5",{"v":17,"d":"17.00"},{"v":44.4,"d":"44.40"},"<1","N/A","http://selleckchem.com/products/Loratadine.html","C22H23ClN2O2","free base","Alavert,Claritin,SCH29851","CCOC(=O)N1CCC(CC1)=C2C3=C(CCC4=C2N=CC=C4)C=C(Cl)C=C3",{"v":5,"d":"5.000"},3,0,2]
["S1359","Losartan Potassium (DuP 753)","d11","L3000-03","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.",462.01,"124750-99-8",{"v":92,"d":"92.00"},199.13,{"v":92,"d":"92.00"},199.13,"http://selleckchem.com/products/losartan-potassium.html","C22H23ClKN6O","Potassium salt","MK 954,DuP 753","[KH].CCCCC1=NC(=C(CO)[N]1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4)Cl",4.241,4,2,8]
["S1361","MGCD-265 analog","e11","L3000-03","in 10mM DMSO","c-Met,RON,Tie-2,VEGFR","Protein Tyrosine Kinase","MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2.",{"v":517.6,"d":"517.60"},"875337-44-3",{"v":104,"d":"104.00"},200.93,"<1","N/A","https://www.selleckchem.com/products/mgcd-265-analog.html","C26H20FN5O2S2","free base","N/A","C[N]1C=NC(=C1)C2=CC3=NC=CC(=C3S2)OC4=CC=C(NC(=S)NC(=O)CC5=CC=CC=C5)C=C4F",6.037,4,2,8]
["S1362","Rigosertib (ON-01910)","f11","L3000-03","in 10mM DMSO","Akt,Apoptosis related,PI3K,PLK","Cell Cycle","Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.",473.47,"1225497-78-8",{"v":95,"d":"95.00"},200.65,{"v":95,"d":"95.00"},200.65,"http://selleckchem.com/products/ON-01910.html","C21H24NNaO8S","Sodium Salt","N/A","[Na+].COC1=CC(=C(\\C=C\\[S](=O)(=O)CC2=CC=C(OC)C(=C2)NCC([O-])=O)C(=C1)OC)OC",0.632,6,1,11]
["S1363","Ki8751","g11","L3000-03","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Ki8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM, >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR.",469.41,"228559-41-9",{"v":47,"d":"47.00"},100.13,"<1","N/A","http://selleckchem.com/products/Ki8751.html","C24H18F3N3O4","free base","N/A","COC1=CC2=NC=CC(=C2C=C1OC)OC3=CC=C(NC(=O)NC4=CC=C(F)C=C4F)C(=C3)F",4.853,5,2,6]
["S1364","Patupilone (Epothilone B)","h11","L3000-03","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.",507.68,"152044-54-7",{"v":102,"d":"102.00"},200.91,"<1","N/A","http://selleckchem.com/products/Epothilone-B.html","C27H41NO6S","free base","EPO906","CC1CCCC2(C)OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.779,5,2,2]
["S1366","BMS-707035","a2","L3000-04","in 10mM DMSO","Integrase","Microbiology","BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.",410.42,"729607-74-3",{"v":38,"d":"38.00"},92.59,"<1","N/A","http://selleckchem.com/products/BMS-707035.html","C17H19FN4O5S","free base","N/A","CN1C(=O)C(=C(N=C1N2CCCC[S]2(=O)=O)C(=O)NCC3=CC=C(F)C=C3)O",0.385,5,2,4]
["S1367","Amonafide","b2","L3000-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.",283.33,"69408-81-7",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://selleckchem.com/products/Amonafide.html","C16H17N3O2","free base","NSC308847,AS1413","CN(C)CCN1C(=O)C2=C3C(=CC=C2)C=C(N)C=C3C1=O",1.162,2,1,3]
["S1368","Acitretin","c2","L3000-04","in 10mM DMSO","Retinoid Receptor","Metabolism","Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.",326.43,"55079-83-9",{"v":20,"d":"20.00"},61.27,"<1","N/A","http://selleckchem.com/products/Acitretin.html","C21H26O3","free base","Etretin, RO 10-1670","COC1=CC(=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(=C1C)C)C",5.665,2,0,6]
["S1369","Bafetinib (INNO-406)","d2","L3000-04","in 10mM DMSO","Bcr-Abl","Angiogenesis","Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.",576.62,"859212-16-1",{"v":100,"d":"100.00"},173.42,"<1","N/A","http://selleckchem.com/products/Bafetinib.html","C30H31F3N8O","free base","NS-187","CN(C)C1CCN(C1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CN=C5",4.197,5,2,9]
["S1373","Daptomycin (LY146032)","e2","L3000-04","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Bacterial,DNA/RNA Synthesis","DNA Damage/DNA Repair","Daptomycin (Cubicin,LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.",1620.67,"103060-53-3",{"v":100,"d":"100.00"},{"v":61.7,"d":"61.70"},{"v":100,"d":"100.00"},{"v":61.7,"d":"61.70"},"http://selleckchem.com/products/Daptomycin.html","C72H101N17O26","free base","Cubicin,LY146032","CCCCCCCCCC(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC3C(C)OC(=O)C(CC(=O)C4=CC=CC=C4N)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCN)NC(=O)CNC3=O)C(C)CC(O)=O",-7.895,21,18,35]
["S1376","Gestodene","f2","L3000-04","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Gestodene (SH B 331,WL 70) is a progestogen hormonal contraceptive.",310.43,"60282-87-3",{"v":62,"d":"62.00"},199.72,"<1","N/A","http://selleckchem.com/products/Gestodene.html","C21H26O2","free base","SH B 331,WL 70","CCC12CCC3C(CCC4=CC(=O)CCC34)C1C=CC2(O)C#C",4.462,1,0,1]
["S1377","Drospirenone","g2","L3000-04","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.",366.49,"67392-87-4",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/Drospirenone.html","C24H30O3","free base","ZK 3059","CC12CCC(=O)C=C1C3CC3C4C2CCC5(C)C4C6CC6C57CCC(=O)O7",3.383,3,0,0]
["S1378","Ruxolitinib (INCB018424)","h2","L3000-04","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",306.37,"941678-49-5",{"v":61,"d":"61.00"},199.11,"<1","N/A","http://selleckchem.com/products/INCB18424.html","C17H18N6","free base","INCB018424","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S1379","Isotretinoin","a3","L3000-04","in 10mM DMSO","Hydroxylase","Metabolism","Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.",300.44,"4759-48-2",{"v":60,"d":"60.00"},199.71,"<1","N/A","http://selleckchem.com/products/Isotretinoin.html","C20H28O2","free base","13-cis retinoic acid","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C/C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1385","Mosapride Citrate","b3","L3000-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Mosapride Citrate (TAK-370, AS-4370, Gasmotin) is a gastroprokinetic agent that acts as a selective 5HT4 agonist.",614.02,"112885-42-4",{"v":90,"d":"90.00"},146.58,"<1","N/A","http://selleckchem.com/products/Mosapride-citrate.html","C21H25ClFN3O3.C6H8O7","Citrate","TAK-370, AS-4370, Gasmotin","CCOC1=CC(=C(Cl)C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(F)C=C3)N.OC(=O)CC(O)(CC(O)=O)C(O)=O",-1.422,6,2,12]
["S1386","Nafamostat mesilate (FUT-175)","c3","L3000-04","in 10mM DMSO","Apoptosis related,COVID-19,SARS-CoV,Serine Protease","Proteases","Nafamostat mesilate (Futhan, FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.",539.58,"82956-11-4",{"v":20,"d":"20.00"},37.07,{"v":53,"d":"53.00"},98.22,"http://selleckchem.com/products/Nafamostat-mesylate.html","C19H17N5O2.2CH4O3S","Dimesylate","Futhan, FUT-175","C[S](O)(=O)=O.C[S](O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(N)=N",1.364,2,3,6]
["S1387","Naftopidil DiHCl","d3","L3000-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Naftopidil DiHCl (Flivas, KT-611, Avishot,BM-15275) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.",465.41,"57149-08-3",{"v":41,"d":"41.00"},88.09,"<1","N/A","http://selleckchem.com/products/Naftopidil-Dihydrochloride.html","C24H28N2O3.2HCl","Dihydrochloride","Flivas, KT-611, Avishot,BM-15275","Cl.Cl.COC1=CC=CC=C1N2CCN(CC2)CC(O)COC3=C4C=CC=CC4=CC=C3",4.726,2,1,7]
["S1389","Omeprazole","e3","L3000-04","in 10mM DMSO","ATPase,Autophagy,Proton Pump","Transmembrane Transporters","Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.",345.42,"73590-58-6",{"v":69,"d":"69.00"},199.76,"<1","N/A","http://selleckchem.com/products/Omeprazole.html","C17H19N3O3S","free base","N/A","COC1=CC=C2[NH]C(=NC2=C1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.904,5,1,5]
["S1390","Ondansetron HCl","f3","L3000-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ondansetron HCl (Ondemet, Emeset, Emetron,GR 38032F,SN 307) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.",329.82,"99614-01-4",{"v":66,"d":"66.00"},200.11,{"v":24,"d":"24.00"},72.77,"http://selleckchem.com/products/Ondansetron-hydrochloride.html","C18H19N3O.HCl","Hydrochloride","Ondemet, Emeset, Emetron,GR 38032F,SN 307","Cl.C[N]1C2=C(C(=O)C(CC2)C[N]3C=CN=C3C)C4=CC=CC=C14",3.016,2,0,2]
["S1391","Oxcarbazepine","g3","L3000-04","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.",252.27,"28721-07-5",{"v":7,"d":"7.00"},27.75,"<1","N/A","http://selleckchem.com/products/Oxcarbazepine.html","C15H12N2O2","free base","GP47680","NC(=O)N1C2=C(CC(=O)C3=C1C=CC=C3)C=CC=C2",2.131,2,1,0]
["S1392","Pelitinib (EKB-569)","h3","L3000-04","in 10mM DMSO","EGFR,MEK,Src","Protein Tyrosine Kinase","Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Pelitinib (EKB-569) also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282 nM, 800 nM and 1255 nM, respectively. Phase2.",467.92,"257933-82-7",{"v":13,"d":"13.00"},27.78,"<1","N/A","http://selleckchem.com/products/Pelitinib.html","C24H23ClFN5O2","free base","N/A","CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(=C2NC3=CC(=C(F)C=C3)Cl)C#N",4.455,3,2,8]
["S1393","Pirarubicin (NSC-333054)","a4","L3000-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Pirarubicin (NSC-333054,THP) is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.",627.64,"72496-41-4",{"v":7,"d":"7.00"},11.15,"<1","N/A","http://selleckchem.com/products/Pirarubicin.html","C32H37NO12","free base","NSC-333054,THP","COC1=CC=CC2=C1C(=O)C3=C(O)C4=C(CC(O)(CC4OC5CC(N)C(OC6CCCCO6)C(C)O5)C(=O)CO)C(=C3C2=O)O",1.091,8,4,7]
["S1394","Pizotifen Malate","b4","L3000-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Pizotifen Malate (Sandomigran, pizotyline,BC-105) is a benzocycloheptane based agent used for recurrent migraine headaches.",429.53,"5189-11-7",{"v":21,"d":"21.00"},48.89,"<1","N/A","http://selleckchem.com/products/Pizotifen-malate.html","C19H21NS.C4H6O5","Malate","Sandomigran, pizotyline,BC-105","CN1CCC(CC1)=C2C3=C(CCC4=C2C=CC=C4)SC=C3.OC(CC(O)=O)C(O)=O",0.292,2,1,3]
["S1396","Resveratrol (SRT501)","c4","L3000-04","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1","N/A","http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1397","Rocuronium Bromide","d4","L3000-04","in 10mM DMSO","AChR","Neuronal Signaling","Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.",609.68,"119302-91-9",{"v":122,"d":"122.00"},{"v":200.1,"d":"200.10"},{"v":122,"d":"122.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Rocuronium-bromide.html","C32H53N2O4.Br","Bromide","ORG 9426","[Br-].CC(=O)OC1C(CC2C3CCC4CC(O)C(CC4(C)C3CCC12C)N5CCOCC5)[N+]6(CCCC6)CC=C",0.282,3,1,6]
["S1398","Stavudine (d4T)","e4","L3000-04","in 10mM DMSO","Reverse Transcriptase","Microbiology","Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.",224.21,"3056-17-5",{"v":45,"d":"45.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/Stavudine.html","C10H12N2O4","free base","BMY-27857, Sanilvudine, NSC 163661,d4T","CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O",-0.515,3,2,2]
["S1401","Tenofovir","f4","L3000-04","in 10mM DMSO","Antiviral,COVID-19,Reverse Transcriptase","Microbiology","Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.",287.21,"147127-20-6",{"v":4,"d":"4.00"},13.93,{"v":2,"d":"2.00"},6.96,"http://selleckchem.com/products/Tenofovir.html","C9H14N5O4P","free base","GS-1278","CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O",-0.772,4,1,5]
["S1403","Tigecycline (GAR-936)","g4","L3000-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Bacterial","Microbiology","Tigecycline (Tygacil, GAR-936, WAY-GAR-936, TBG-MINO) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline induces autophagy by downregulating the PI3K-AKT-mTOR pathway.",585.65,"220620-09-7",{"v":100,"d":"100.00"},170.75,{"v":100,"d":"100.00"},170.75,"http://selleckchem.com/products/Tigecycline.html","C29H39N5O8","free base","Tygacil, GAR-936, WAY-GAR-936, TBG-MINO","CN(C)C1C2CC3CC4=C(C(=C(NC(=O)CNC(C)(C)C)C=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",-0.381,4,6,7]
["S1404","Trilostane","h4","L3000-04","in 10mM DMSO","Dehydrogenase","Metabolism","Trilostane (WIN 24540) is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.",329.43,"13647-35-3",{"v":65,"d":"65.00"},197.31,"<1","N/A","http://selleckchem.com/products/Trilostane.html","C20H27NO3","free base","WIN 24540","CC12CCC3C(CCC45OC4C(=C(CC35C)C#N)O)C1CCC2O",2.434,1,2,0]
["S1405","Vecuronium Bromide","a5","L3000-04","in 10mM DMSO","AChR","Neuronal Signaling","Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.",637.73,"50700-72-6",{"v":100,"d":"100.00"},156.81,{"v":4,"d":"4.00"},6.27,"http://selleckchem.com/products/Vecuronium-Bromide.html","C34H57N2O4.Br","Bromide","ORG NC45","[Br-].CC(=O)OC1CC2CCC3C(CCC4(C)C3CC(C4OC(C)=O)[N+]5(C)CCCCC5)C2(C)CC1N6CCCCC6",{"v":1.73,"d":"1.730"},4,0,6]
["S1407","Bimatoprost","b5","L3000-04","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.",415.57,"155206-00-1",{"v":36,"d":"36.00"},86.63,"<1","N/A","http://selleckchem.com/products/Bimatoprost.html","C25H37NO4","free base","AGN 192024","CCNC(=O)CCC\\C=C/CC1C(O)CC(O)C1/C=C/C(O)CCC2=CC=CC=C2",{"v":3.03,"d":"3.030"},1,4,12]
["S1408","Linezolid (PNU-100766)","c5","L3000-04","in 10mM DMSO","Antibiotics","Microbiology","Linezolid (Zyvoxid, Zyvoxam,PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.",337.35,"165800-03-3",{"v":67,"d":"67.00"},198.61,"<1","N/A","http://selleckchem.com/products/Linezolid(Zyvox).html","C16H20FN3O4","free base","Zyvoxid, Zyvoxam,PNU-100766","CC(=O)NCC1CN(C(=O)O1)C2=CC=C(N3CCOCC3)C(=C2)F",0.894,4,1,4]
["S1409","Alfuzosin HCl","d5","L3000-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Alfuzosin HCI(SL 77499 HCl)  is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).",425.91,"81403-68-1",{"v":85,"d":"85.00"},199.57,{"v":85,"d":"85.00"},199.57,"http://selleckchem.com/products/Alfuzosin-hydrochloride.html","C19H27N5O4.HCl","Hydrochloride","SL 77499 HCl","Cl.COC1=C(OC)C=C2C(=NC(=NC2=C1)N(C)CCCNC(=O)C3CCCO3)N",{"v":1.8,"d":"1.800"},6,2,8]
["S1422","Droxinostat","e5","L3000-04","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.",243.69,"99873-43-5",{"v":49,"d":"49.00"},201.08,"<1","N/A","http://selleckchem.com/products/Droxinostat.html","C11H14ClNO3","free base","NS 41080","CC1=CC(=CC=C1OCCCC(=O)NO)Cl",{"v":2.4,"d":"2.400"},2,1,5]
["S1425","Ranolazine 2HCl","f5","L3000-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine 2HCl (RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.",500.46,"95635-56-6",{"v":100,"d":"100.00"},199.82,{"v":100,"d":"100.00"},199.82,"http://selleckchem.com/products/Ranolazine-dihydrochloride.html","C24H33N3O4.2HCl","Dihydrochloride","RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride","Cl.Cl.COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",3.755,3,2,9]
["S1426","Repaglinide","g5","L3000-04","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Repaglinide (AG-EE 623 ZW) is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.",452.59,"135062-02-1",{"v":91,"d":"91.00"},201.06,"<1","N/A","http://selleckchem.com/products/Repaglinide.html","C27H36N2O4","free base","AG-EE 623 ZW","CCOC1=C(C=CC(=C1)CC(=O)NC(CC(C)C)C2=CC=CC=C2N3CCCCC3)C(O)=O",5.307,3,1,10]
["S1430","Rolipram (ZK-62711)","h5","L3000-04","in 10mM DMSO","PDE","Metabolism","The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.",275.34,"61413-54-5",{"v":55,"d":"55.00"},199.75,"<1","N/A","http://selleckchem.com/products/Rolipram.html","C16H21NO3","free base","ZK-62711, SB 95952","COC1=C(OC2CCCC2)C=C(C=C1)C3CNC(=O)C3",2.349,3,1,4]
["S1431","Sildenafil Citrate","a6","L3000-04","in 10mM DMSO","PDE","Metabolism","Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.",{"v":666.7,"d":"666.70"},"171599-83-0",{"v":20,"d":"20.00"},{"v":30,"d":"30.00"},"<1","N/A","http://selleckchem.com/products/Sildenafil-citrate.html","C22H30N6O4S.C6H8O7","Citrate","N/A","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.OC(=O)CC(O)(CC(O)=O)C(O)=O",-2.107,9,1,12]
["S1432","Sumatriptan Succinate","b6","L3000-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Sumatriptan Succinate (GR 43175) is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.",413.49,"103628-48-4",{"v":83,"d":"83.00"},200.73,{"v":83,"d":"83.00"},200.73,"http://selleckchem.com/products/Sumatriptan-succinate.html","C14H21N3O2S.C4H6O4","Succinate","GR 43175","CN[S](=O)(=O)CC1=CC=C2[NH]C=C(CCN(C)C)C2=C1.OC(=O)CCC(O)=O",-1.958,4,2,9]
["S1437","Tizanidine HCl","c6","L3000-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.",290.17,"64461-82-1",{"v":10,"d":"10.00"},34.46,{"v":15,"d":"15.00"},51.69,"http://selleckchem.com/products/Tizanidine-hydrochloride.html","C9H8ClN5S.HCl","Hydrochloride","DS 103-282","Cl.ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1",2.199,3,2,2]
["S1438","Topiramate","d6","L3000-04","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.",339.36,"97240-79-4",{"v":68,"d":"68.00"},200.38,"<1","N/A","http://selleckchem.com/products/Topiramate.html","C12H21NO8S","free base","MCN 4853, RWJ 17021","CC1(C)OC2COC3(CO[S](N)(=O)=O)OC(C)(C)OC3C2O1",-1.932,6,1,3]
["S1439","Tranilast (SB 252218)","e6","L3000-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tranilast (SB 252218, MK-341, Rizaben, MK 341, Tranpro) is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.",327.33,"53902-12-8",{"v":66,"d":"66.00"},201.63,"<1","N/A","http://selleckchem.com/products/Tranilast.html","C18H17NO5","free base","SB 252218, MK-341, Rizaben, MK 341, Tranpro","COC1=C(OC)C=C(\\C=C\\C(=O)NC2=CC=CC=C2C(O)=O)C=C1",2.679,4,1,6]
["S1441","Venlafaxine HCl","f6","L3000-04","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.",313.86,"99300-78-4",{"v":55.5,"d":"55.50"},176.83,{"v":55.5,"d":"55.50"},176.83,"http://selleckchem.com/products/Venlafaxine-hydrochloride.html","C17H27NO2.HCl","Hydrochloride","Wy 453 HCl","Cl.COC1=CC=C(C=C1)C(CN(C)C)C2(O)CCCCC2",3.404,1,0,5]
["S1442","Voriconazole (UK-109496)","g6","L3000-04","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Voriconazole (Vfend,UK-109496) is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.",349.31,"137234-62-9",{"v":70,"d":"70.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/Voriconazole.html","C16H14F3N5O","free base","Vfend,UK-109496","CC(C1=NC=NC=C1F)C(O)(C[N]2C=NC=N2)C3=CC=C(F)C=C3F",2.071,4,0,5]
["S1443","Zileuton (A-64077)","h6","L3000-04","in 10mM DMSO","Apoptosis related,Ferroptosis,Lipoxygenase","Metabolism","Zileuton (A-64077, Abbott 64077, ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. Zileuton induces apoptosis while inhibits ferroptosis.",236.29,"111406-87-2",{"v":47,"d":"47.00"},198.91,"<1","N/A","http://selleckchem.com/products/Zileuton.html","C11H12N2O2S","free base","A-64077, Abbott 64077, ZYFLO","CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1",2.184,1,1,2]
["S1444","Ziprasidone HCl","a7","L3000-04","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.",{"v":449.4,"d":"449.40"},"122883-93-6",{"v":90,"d":"90.00"},200.27,"<1","N/A","http://selleckchem.com/products/Ziprasidone-hydrochloride.html","C21H21ClN4OS.HCl","Hydrochloride","CP-88059","Cl.ClC1=CC2=C(CC(=O)N2)C=C1CCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.641,2,1,4]
["S1445","Zonisamide","b7","L3000-04","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.",212.23,"68291-97-4",{"v":42,"d":"42.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/Zonisamide.html","C8H8N2O3S","free base","Zonegran,CI-912,AD 810","N[S](=O)(=O)CC1=NOC2=CC=CC=C12",0.411,4,1,2]
["S1451","Aurora A Inhibitor I (TC-S 7010)","c7","L3000-04","in 10mM DMSO","Apoptosis related,Aurora Kinase","Cell Cycle","Aurora A Inhibitor I (TC-S 7010) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.",588.07,"1158838-45-9",{"v":118,"d":"118.00"},200.66,"<1","N/A","http://selleckchem.com/products/Aurora-A-Inhibitor-I.html","C31H31ClFN7O2","free base","N/A","CCN1CCN(CC1)C(=O)CC2=CC=C(NC3=NC(=C(F)C=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)C=C2",5.621,4,3,9]
["S1452","Ispinesib (SB-715992)","d7","L3000-04","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death.",517.06,"336113-53-2",{"v":103,"d":"103.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Ispinesib-mesilate(SB-715992).html","C30H33ClN4O2","free base","CK0238273","CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4",5.259,3,1,9]
["S1453","Tipifarnib (R115777)","e7","L3000-04","in 10mM DMSO","FTase,Transferase","Metabolism","Tipifarnib (R115777, IND 58359) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.",{"v":489.4,"d":"489.40"},"192185-72-1",{"v":14,"d":"14.00"},28.61,"<1","N/A","http://selleckchem.com/products/Tipifarnib(R115777).html","C27H22Cl2N4O","free base","IND 58359","C[N]1C=NC=C1C(N)(C2=CC=C(Cl)C=C2)C3=CC4=C(C=C3)N(C)C(=O)C=C4C5=CC(=CC=C5)Cl",4.808,2,1,4]
["S1454","PHA-680632","f7","L3000-04","in 10mM DMSO","Aurora Kinase","Cell Cycle","PHA-680632 is a potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.",501.62,"398493-79-3",{"v":100,"d":"100.00"},199.35,"<1","N/A","http://selleckchem.com/products/PHA-680632.html","C28H35N7O2","free base","N/A","CCC1=CC=CC(=C1NC(=O)N2CC3=C(C2)C(=N[NH]3)NC(=O)C4=CC=C(C=C4)N5CCN(C)CC5)CC",4.339,3,3,6]
["S1456","Zibotentan (ZD4054)","g7","L3000-04","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.",424.43,"186497-07-4",{"v":24,"d":"24.00"},56.55,"<1","N/A","http://selleckchem.com/products/Zibotentan(ZD4054).html","C19H16N6O4S","free base","N/A","COC1=NC(=CN=C1N[S](=O)(=O)C2=CC=CN=C2C3=CC=C(C=C3)C4=NN=CO4)C",1.456,9,1,6]
["S1457","Atazanavir (BMS-232632) Sulfate","h7","L3000-04","in 10mM DMSO","HIV Protease","Proteases","Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.",802.93,"229975-97-7",{"v":104,"d":"104.00"},129.53,"<1","N/A","http://selleckchem.com/products/Atazanavir.html","C38H52N6O7.H2SO4","Sulfate","BMS-232632-05, Reyataz","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C.O[S](O)(=O)=O",4.083,7,5,18]
["S1458","Neflamapimod (VX-745)","a8","L3000-04","in 10mM DMSO","p38 MAPK","MAPK","Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.",436.26,"209410-46-8",{"v":15,"d":"15.00"},34.38,"<1","N/A","http://selleckchem.com/products/VX-745.html","C19H9Cl2F2N3OS","free base","N/A","FC1=CC(=C(SC2=NN3C=NC(=O)C(=C3C=C2)C4=C(Cl)C=CC=C4Cl)C=C1)F",5.342,3,0,3]
["S1459","Thiazovivin","b8","L3000-04","in 10mM DMSO","ROCK","Cell Cycle","Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation.",311.36,"1226056-71-8",{"v":15,"d":"15.00"},48.18,"<1","N/A","http://selleckchem.com/products/Thiazovivin.html","C15H13N5OS","free base","N/A","O=C(NCC1=CC=CC=C1)C2=CSC(=N2)NC3=CC=NC=N3",2.357,4,2,5]
["S1460","SP600125","c8","L3000-04","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,FLT3,JNK,Serine/threonin kinase,Trk receptor","MAPK","SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.",220.23,"129-56-6",{"v":44,"d":"44.00"},199.79,"<1","N/A","http://selleckchem.com/products/SP600125.html","C14H8N2O","free base","Nsc75890","O=C1C2=C(C=CC=C2)C3=N[NH]C4=CC=CC1=C34",2.994,2,1,0]
["S1462","AZD6482","d8","L3000-04","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.",408.45,"1173900-33-8",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://selleckchem.com/products/azd6482.html","C22H24N4O4","free base","KIN-193","CC(NC1=CC=CC=C1C(O)=O)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.003,4,1,5]
["S1465","Moxifloxacin (BAY12-8039) HCl","e8","L3000-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Moxifloxacin (Avelox, Avalox,BAY12-8039 HCl) is a fourth-generation synthetic fluoroquinolone antibacterial agent.",437.89,"186826-86-8",{"v":87,"d":"87.00"},198.68,{"v":60,"d":"60.00"},137.02,"https://www.selleckchem.com/products/Moxifloxacin-hcl.html","C21H24FN3O4.HCl","Hydrochloride","Avelox, Avalox,BAY12-8039 HCl","Cl.COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CC4CCCNC4C3)F)C5CC5",{"v":-0.32,"d":"-0.320"},3,1,4]
["S1467","Doxercalciferol","f8","L3000-04","in 10mM DMSO","Vitamin","Metabolism","Doxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.",412.65,"54573-75-0",{"v":83,"d":"83.00"},201.14,"<1","N/A","http://selleckchem.com/products/Doxercalciferol(Hectorol).html","C28H44O2","free base","1α-hydroxyvitamin D2","CC(C)C(C)/C=C/C(C)C1CCC2C(/CCCC12C)=C/C=C/3CC(O)CC(O)C3=C",6.337,0,2,5]
["S1468","Alfacalcidol","g8","L3000-04","in 10mM DMSO","Vitamin","Metabolism","Alfacalcidol (1-hydroxycholecalciferol) is a non-selective VDR activator medication.",400.64,"41294-56-8",{"v":80,"d":"80.00"},199.68,"<1","N/A","http://selleckchem.com/products/Alfacalcidol.html","C27H44O2","free base","1-hydroxycholecalciferol","CC(C)CCCC(C)C1CCC2/C(CCCC12C)=C\\C=C3/CC(O)CC(O)C3=C",{"v":6.53,"d":"6.530"},0,2,6]
["S1470","Orantinib (SU6668)","h8","L3000-04","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.",310.35,"252916-29-3",{"v":62,"d":"62.00"},199.77,"<1","N/A","http://selleckchem.com/products/TSU-68(SU6668).html","C18H18N2O3","free base","TSU-68","CC1=C(CCC(O)=O)C(=C([NH]1)/C=C/2C(=O)NC3=CC=CC=C23)C",2.868,2,2,4]
["S1474","GSK429286A","a9","L3000-04","in 10mM DMSO","ROCK","Cell Cycle","GSK429286A (RHO-15) is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.",432.37,"864082-47-3",{"v":87,"d":"87.00"},201.22,"<1","N/A","http://selleckchem.com/products/GSK429286A.html","C21H16F4N4O2","free base","RHO-15","CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(F)C=C4[NH]N=CC4=C3",3.033,3,3,4]
["S1475","Pimasertib (AS-703026)","b9","L3000-04","in 10mM DMSO","MEK","MAPK","Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.",{"v":431.2,"d":"431.20"},"1236699-92-5",{"v":86,"d":"86.00"},199.44,"<1","N/A","http://selleckchem.com/products/AS703026.html","C15H15FIN3O3","free base","MSC1936369B, SAR 245509","OCC(O)CNC(=O)C1=CC=NC=C1NC2=C(F)C=C(I)C=C2",1.171,2,4,6]
["S1476","SB525334","c9","L3000-04","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.",343.42,"356559-20-1",{"v":68,"d":"68.00"},198.01,"<1","N/A","http://selleckchem.com/products/SB-525334.html","C21H21N5","free base","N/A","CC1=NC(=CC=C1)C2=C([NH]C(=N2)C(C)(C)C)C3=CC=C4N=CC=NC4=C3",4.305,4,1,3]
["S1480","Lomibuvir (VX-222)","d9","L3000-04","in 10mM DMSO","HCV Protease","Proteases","Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.",445.61,"1026785-59-0",{"v":89,"d":"89.00"},199.73,"<1","N/A","http://selleckchem.com/products/VX-222.html","C25H35NO4S","free base","VCH-222","CC1CCC(CC1)C(=O)N(C2CCC(O)CC2)C3=C(SC(=C3)C#CC(C)(C)C)C(O)=O",6.021,2,1,6]
["S1481","Zosuquidar (LY335979) 3HCl","e9","L3000-04","in 10mM DMSO","P-gp","Transmembrane Transporters","Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.",636.99,"167465-36-3",{"v":100,"d":"100.00"},156.99,{"v":23,"d":"23.00"},36.11,"http://selleckchem.com/products/LY335979.html","C32H31F2N3O2.3HCl","Trihydrochlorid","RS 33295-198 (D06387) 3HCl","Cl.Cl.Cl.OC(COC1=CC=CC2=C1C=CC=N2)CN3CCN(CC3)C4C5=C(C=CC=C5)C6C(C7=C4C=CC=C7)C6(F)F",5.845,2,1,6]
["S1483","Iloperidone","f9","L3000-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Iloperidone (HP873) is a dopamine (D2)/serotonin (5-HT2) receptor antagonist, used for the treatment of schizophrenia.",426.48,"133454-47-4",{"v":27,"d":"27.00"},63.31,"<1","N/A","http://selleckchem.com/products/Iloperidone(Fanapt).html","C24H27FN2O4","free base","HP873","COC1=C(OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C=CC(=C1)C(C)=O",4.016,5,0,8]
["S1484","MC1568","g9","L3000-04","in 10mM DMSO","HDAC","Cytoskeletal Signaling","MC1568 is a selective HDAC inhibitor for maize HD1-A with IC50 of 100 nM in a cell-free assay. It is 34-fold more selective for HD1-A than HD1-B.",314.31,"852475-26-4",{"v":13,"d":"13.00"},41.36,"<1","N/A","http://selleckchem.com/products/MC1568.html","C17H15FN2O3","free base","N/A","C[N]1C=C(/C=C/C(=O)C2=CC=CC(=C2)F)C=C1\\C=C\\C(=O)NO",2.981,2,1,5]
["S1485","HMN-214","h9","L3000-04","in 10mM DMSO","PLK","Cell Cycle","HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.",424.47,"173529-46-9",{"v":12,"d":"12.00"},28.27,"<1","N/A","http://selleckchem.com/products/HMN-214.html","C22H20N2O5S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)N(C(C)=O)C2=C(C=CC=C2)\\C=C\\C3=CC=[N+]([O-])C=C3",2.282,4,0,6]
["S1486","AEE788 (NVP-AEE788)","a10","L3000-04","in 10mM DMSO","EGFR,HER2,VEGFR","Protein Tyrosine Kinase","AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.",440.58,"497839-62-0",{"v":88,"d":"88.00"},199.74,"<1","N/A","http://selleckchem.com/products/AEE788.html","C27H32N6","free base","N/A","CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC(C)C5=CC=CC=C5)N=CN=C4[NH]3",5.042,2,2,7]
["S1487","PHA-793887","b10","L3000-04","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1.",361.48,"718630-59-2",{"v":72,"d":"72.00"},199.18,"<1","N/A","http://selleckchem.com/products/PHA-793887.html","C19H31N5O2","free base","N/A","CC(C)CC(=O)NC1=N[NH]C2=C1CN(C(=O)C3CCN(C)CC3)C2(C)C",1.895,3,2,4]
["S1488","Naratriptan HCl","c10","L3000-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.",371.93,"143388-64-1",{"v":74,"d":"74.00"},198.96,{"v":22,"d":"22.00"},59.15,"http://selleckchem.com/products/Naratriptan(Amerge).html","C17H25N3O2S.HCl","Hydrochloride","N/A","Cl.CN[S](=O)(=O)CCC1=CC=C2[NH]C=C(C3CCN(C)CC3)C2=C1",2.435,2,2,5]
["S1489","PIK-93","d10","L3000-04","in 10mM DMSO","PI4K","PI3K/Akt/mTOR","PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.",389.88,"593960-11-3",{"v":78,"d":"78.00"},200.06,"<1","N/A","http://selleckchem.com/products/PIK-93.html","C14H16ClN3O4S2","free base","N/A","CC(=O)NC1=NC(=C(S1)C2=CC(=C(Cl)C=C2)[S](=O)(=O)NCCO)C",1.076,4,3,6]
["S1490","Ponatinib (AP24534)","e10","L3000-04","in 10mM DMSO","Autophagy,Bcr-Abl,FGFR,PDGFR,Src,VEGFR","Angiogenesis","Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.",532.56,"943319-70-8",{"v":30,"d":"30.00"},56.33,"<1","N/A","http://selleckchem.com/products/AP24534.html","C29H27F3N6O","free base","AP24534","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F",4.884,3,1,7]
["S1491","Fludarabine (NSC 118218)","f10","L3000-04","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite,STAT","JAK/STAT","Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.",285.23,"21679-14-1",{"v":57,"d":"57.00"},199.84,"<1","N/A","http://selleckchem.com/products/Fludarabine(Fludara).html","C10H12FN5O4","Free Base","FaraA, Fludarabinum, NSC 118218","NC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)F",-1.312,4,4,2]
["S1497","Pralatrexate (NSC 754230)","g10","L3000-04","in 10mM DMSO","Apoptosis related,DHFR","Metabolism","Pralatrexate (NSC 754230) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.",477.47,"146464-95-1",{"v":28,"d":"28.00"},58.64,"<1","N/A","http://selleckchem.com/products/Pralatrexate(Folotyn).html","C23H23N7O5","free base","NSC 754230","NC1=NC(=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1)N",{"v":1.94,"d":"1.940"},7,3,10]
["S1499","Cefaclor","h10","L3000-04","in 10mM DMSO","Antibiotics","Microbiology","Cefaclor (Cefachlor, Cefaclorum) is a cephalosporin antibiotic.",385.82,"70356-03-5",{"v":11,"d":"11.00"},28.51,"<1","N/A","http://selleckchem.com/products/Cefaclor-(Ceclor).html","C15H14ClN3O4S.H2O","monohydrate","Cefachlor, Cefaclorum","O.NC(C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)Cl)C3=CC=CC=C3",{"v":-2.54,"d":"-2.540"},3,2,4]
["S1500","Betamethasone","a11","L3000-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.",392.46,"378-44-9",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Betamethasone-(Celestone).html","C22H29FO5","Free Base","NSC-39470, SCH-4831","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1501","Mycophenolate mofetil (RS-61443)","b11","L3000-04","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Mycophenolate Mofetil (RS 61443, Mycophenolic acid morpholinoethyl ester, CellCept, TM-MMF) is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.",433.49,"128794-94-5",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/Mycophenolate-mofetil-(CellCept).html","C23H31NO7","free base","Mycophenolic acid morpholinoethyl ester, CellCept, RS 61443, TM-MMF","COC1=C(C)C2=C(C(=O)OC2)C(=C1C\\C=C(C)\\CCC(=O)OCCN3CCOCC3)O",3.209,6,1,10]
["S1504","Dyphylline","c11","L3000-04","in 10mM DMSO","PDE","Metabolism","Dyphylline (Diprophylline) is a xanthine derivative with bronchodilator and vasodilator effects.",254.24,"479-18-5",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"http://selleckchem.com/products/Dyphylline(Dilor).html","C10H14N4O4","free base","Diprophylline","CN1C(=O)N(C)C2=C([N](CC(O)CO)C=N2)C1=O",-1.151,3,2,3]
["S1505","Aztreonam","d11","L3000-04","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.",435.43,"78110-38-0",{"v":87,"d":"87.00"},{"v":199.8,"d":"199.80"},{"v":11,"d":"11.00"},25.26,"http://selleckchem.com/products/Aztreonam(Azactam).html","C13H17N5O8S2","free base","SQ 26776","CC1C(NC(=O)\\C(=N/OC(C)(C)C(O)=O)C2=CSC(=N2)N)C(=O)N1[S](O)(=O)=O",-1.035,6,2,7]
["S1512","Tadalafil (IC351)","e11","L3000-04","in 10mM DMSO","PDE","Metabolism","Tadalafil (IC351) is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11",{"v":389.4,"d":"389.40"},"171596-29-5",{"v":78,"d":"78.00"},200.31,"<1","N/A","http://selleckchem.com/products/Tadalafil(Cialis).html","C22H19N3O4","free base","IC351","CN1CC(=O)N2C(CC3=C([NH]C4=C3C=CC=C4)C2C5=CC=C6OCOC6=C5)C1=O",2.183,4,1,1]
["S1515","Pracinostat (SB939)","f11","L3000-04","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.",358.48,"929016-96-6",{"v":72,"d":"72.00"},200.85,"<1","N/A","http://selleckchem.com/products/SB939.html","C20H30N4O2","free base","N/A","CCCCC1=NC2=CC(=CC=C2[N]1CCN(CC)CC)\\C=C\\C(=O)NO",{"v":3.71,"d":"3.710"},2,1,10]
["S1517","Natamycin","g11","L3000-04","in 10mM DMSO","Fungal","Microbiology","Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference",665.73,"7681-93-8",{"v":7,"d":"7.00"},10.51,"<1","N/A","http://selleckchem.com/products/Natamycin(Pimaricin).html","C33H47NO13","free base","Pimaricin","CC1C/C=C/C=C/C=C/C=C/C(CC2OC(O)(CC(O)CC3OC3/C=C/C(=O)O1)CC(O)C2C(O)=O)OC4OC(C)C(O)C(N)C4O",-2.824,7,5,3]
["S1523","Voxtalisib (XL765) Analogue","h11","L3000-04","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",599.66,"1349796-36-6",{"v":12,"d":"12.00"},20.01,"<1","N/A","http://selleckchem.com/products/XL765(SAR245409).html","C31H29N5O6S","free base","SAR245409","COC1=CC(=CC(=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=C(NC(=O)C5=CC=C(C)C(=C5)OC)C=C4)OC",5.631,8,3,10]
["S1524","AT7519","a2","L3000-05","in 10mM DMSO","Apoptosis related,CDK,GSK-3","Cell Cycle","AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also decrease GSK3β phosphorylation. AT7519 induces apoptosis. Phase 2.",382.24,"844442-38-2",{"v":10,"d":"10.00"},26.16,"<1","N/A","http://selleckchem.com/products/AT7519.html","C16H17Cl2N5O2","Free Base","N/A","ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",1.599,3,4,4]
["S1525","Adavosertib (MK-1775)","b2","L3000-05","in 10mM DMSO","Wee1","Cell Cycle","Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.",{"v":500.6,"d":"500.60"},"955365-80-7",{"v":80,"d":"80.00"},159.81,"N/A","N/A","http://selleckchem.com/products/MK-1775.html","C27H32N8O2","free base","AZD1775","CN1CCN(CC1)C2=CC=C(NC3=NC4=C(C=N3)C(=O)N(CC=C)N4C5=NC(=CC=C5)C(C)(C)O)C=C2",4.158,4,1,7]
["S1526","Quizartinib (AC220)","c2","L3000-05","in 10mM DMSO","Apoptosis related,FLT3,Target Protein Ligand","Angiogenesis","Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.",560.67,"950769-58-1",{"v":33,"d":"33.00"},58.86,"<1","N/A","http://selleckchem.com/products/AC-220.html","C29H32N6O4S","free base","N/A","CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=C[N]4C(=N3)SC5=CC(=CC=C45)OCCN6CCOCC6",5.064,6,2,8]
["S1528","LY2811376","d2","L3000-05","in 10mM DMSO","BACE,Beta Amyloid","Proteases","LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.",320.36,"1194044-20-6",{"v":16,"d":"16.00"},49.94,"<1","N/A","http://selleckchem.com/products/LY2811376.html","C15H14F2N4S","free base","N/A","CC1(CCSC(=N1)N)C2=CC(=C(F)C=C2F)C3=CN=CN=C3",2.478,3,1,2]
["S1529","Hesperadin","e2","L3000-05","in 10mM DMSO","Aurora Kinase","Cell Cycle","Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.",516.65,"422513-13-1",{"v":103,"d":"103.00"},199.36,"<1","N/A","http://selleckchem.com/products/Hesperadin.html","C29H32N4O3S","free base","N/A","CC[S](=O)(=O)NC1=CC=C2NC(=O)C(=C(NC3=CC=C(CN4CCCCC4)C=C3)/C5=CC=CC=C5)/C2=C1",4.071,3,3,8]
["S1530","BIX 02188","f2","L3000-05","in 10mM DMSO","MEK","MAPK","BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.",412.48,"1094614-84-2",{"v":43,"d":"43.00"},104.25,"<1","N/A","http://selleckchem.com/products/BIX-02188.html","C25H24N4O2","free base","N/A","CNC(=O)C1=CC=C\\2C(=C1)NC(=O)C2=C(\\NC3=CC(=CC=C3)CN(C)C)C4=CC=CC=C4",3.102,2,3,6]
["S1532","AZD7762","g2","L3000-05","in 10mM DMSO","Chk","Cell Cycle","AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.",362.42,"860352-01-8",{"v":50,"d":"50.00"},137.96,"<1","N/A","http://selleckchem.com/products/AZD7762.html","C17H19FN4O2S","free base","N/A","NC(=O)NC1=C(SC(=C1)C2=CC(=CC=C2)F)C(=O)NC3CCCNC3",2.009,2,4,4]
["S1533","R406 (free base)","h2","L3000-05","in 10mM DMSO","Apoptosis related,FLT3,Syk","Angiogenesis","R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 (free base) triggers apoptosis. Phase 1.",470.45,"841290-80-0",{"v":21,"d":"21.00"},44.64,"<1","N/A","http://selleckchem.com/products/R406(free-base).html","C22H23FN6O5","free base","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC(=C(F)C=N2)NC3=NC4=C(OC(C)(C)C(=O)N4)C=C3)OC",3.881,8,3,7]
["S1536","CP-673451","a3","L3000-05","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.",{"v":417.5,"d":"417.50"},"343787-29-1",{"v":28,"d":"28.00"},67.07,"<1","N/A","http://selleckchem.com/products/CP-673451.html","C24H27N5O2","free base","N/A","COCCOC1=CC=C2[N](C=NC2=C1)C3=NC4=C(C=CC=C4C=C3)N5CCC(N)CC5",3.011,4,1,6]
["S1537","Vadimezan (ASA404)","b3","L3000-05","in 10mM DMSO","Antiviral,IFN,STING,TNF-alpha,VDA","Angiogenesis","Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.",282.29,"117570-53-3",{"v":7,"d":"7.00"},{"v":24.8,"d":"24.80"},"<1","N/A","http://selleckchem.com/products/DMXAA(ASA404).html","C17H14O4","free base","NSC 640488, DMXAA","CC1=C(C)C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(O)=O",3.601,3,0,2]
["S1541","Selisistat (EX 527)","c3","L3000-05","in 10mM DMSO","Sirtuin","Epigenetics","Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.",248.71,"49843-98-3",{"v":49,"d":"49.00"},197.02,"<1","N/A","http://selleckchem.com/products/EX-527.html","C13H13ClN2O","free base","SEN0014196","NC(=O)C1CCCC2=C1[NH]C3=C2C=C(Cl)C=C3",3.149,1,2,1]
["S1547","Febuxostat","d3","L3000-05","in 10mM DMSO","ROS","Immunology & Inflammation","Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.",316.37,"144060-53-7",{"v":63,"d":"63.00"},199.13,"<1","N/A","http://selleckchem.com/products/Febuxostat(Uloric).html","C16H16N2O3S","free base","TMX 67, TEI-6720","CC(C)COC1=C(C=C(C=C1)C2=NC(=C(S2)C(O)=O)C)C#N",3.468,3,0,5]
["S1548","Dapagliflozin (BMS-512148)","e3","L3000-05","in 10mM DMSO","SGLT","GPCR & G Protein","Dapagliflozin (BMS-512148) is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.",408.87,"461432-26-8",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Dapagliflozin.html","C21H25ClO6","free base","BMS-512148","CCOC1=CC=C(CC2=CC(=CC=C2Cl)C3OC(CO)C(O)C(O)C3O)C=C1",2.409,2,4,6]
["S1549","Nebivolol hydrochloride (R-65824)","f3","L3000-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.",{"v":441.9,"d":"441.90"},"152520-56-4",{"v":88,"d":"88.00"},199.14,"<1","N/A","http://selleckchem.com/products/Nebivolol(Bystolic).html","C22H25F2NO4.HCl","Hydrochloride","R-65824 hydrochloride","Cl.OC(CNCC(O)C1CCC2=C(O1)C=CC(=C2)F)C3CCC4=CC(=CC=C4O3)F",3.939,2,3,6]
["S1550","Pimobendan","g3","L3000-05","in 10mM DMSO","PDE","Metabolism","Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.",334.37,"74150-27-9",{"v":67,"d":"67.00"},200.38,"<1","N/A","http://selleckchem.com/products/Pimobendan(Vetmedin).html","C19H18N4O2","free base","UD-CG 115 BS","COC1=CC=C(C=C1)C2=NC3=CC(=CC=C3[NH]2)C4=NNC(=O)CC4C",2.936,4,2,3]
["S1555","AZD8055","h3","L3000-05","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.",465.54,"1009298-09-2",{"v":50,"d":"50.00"},{"v":107.4,"d":"107.40"},"<1","N/A","http://selleckchem.com/products/AZD8055.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=C(C=C2)C(=NC(=N3)N4CCOCC4C)N5CCOCC5C",3.274,6,1,5]
["S1556","PHT-427","a4","L3000-05","in 10mM DMSO","Akt,PDPK1","PI3K/Akt/mTOR","PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.",409.61,"1191951-57-1",{"v":82,"d":"82.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHT-427.html","C20H31N3O2S2","free base","CS-0223","CCCCCCCCCCCCC1=CC=C(C=C1)[S](=O)(=O)NC2=NN=CS2",6.296,4,1,14]
["S1557","KRN 633","b4","L3000-05","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell.",416.86,"286370-15-8",{"v":9,"d":"9.00"},21.59,"<1","N/A","http://selleckchem.com/products/KRN-633.html","C20H21ClN4O4","free base","N/A","CCCNC(=O)NC1=CC=C(OC2=NC=NC3=CC(=C(OC)C=C23)OC)C=C1Cl",4.107,6,2,7]
["S1558","AT7867","c4","L3000-05","in 10mM DMSO","Akt,S6 Kinase","PI3K/Akt/mTOR","AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.",337.85,"857531-00-1",{"v":68,"d":"68.00"},201.27,"<1","N/A","http://selleckchem.com/products/AT7867.html","C20H20ClN3","free base","N/A","ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=C[NH]N=C4",{"v":3.85,"d":"3.850"},1,2,3]
["S1561","BMS-777607","d4","L3000-05","in 10mM DMSO","Axl,c-Met,RON,Tyro3","Protein Tyrosine Kinase","BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.",512.89,"1025720-94-8",{"v":47,"d":"47.00"},91.64,"<1","N/A","http://selleckchem.com/products/BMS-777607.html","C25H19ClF2N4O4","free base","BMS 817378","CCOC1=C(C(=O)NC2=CC=C(OC3=CC=NC(=C3Cl)N)C(=C2)F)C(=O)N(C=C1)C4=CC=C(F)C=C4",3.517,5,2,7]
["S1565","Lumacaftor (VX-809)","e4","L3000-05","in 10mM DMSO","CFTR","Transmembrane Transporters","Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.",452.41,"936727-05-8",{"v":90,"d":"90.00"},198.93,"<1","N/A","http://selleckchem.com/products/VX-809.html","C24H18F2N2O5","free base","VRT 826809","CC1=C(N=C(NC(=O)C2(CC2)C3=CC4=C(OC(F)(F)O4)C=C3)C=C1)C5=CC=CC(=C5)C(O)=O",6.411,5,1,5]
["S1567","Pomalidomide (CC-4047)","f4","L3000-05","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.",273.24,"19171-19-8",{"v":54,"d":"54.00"},197.63,"<1","N/A","http://selleckchem.com/products/Pomalidomide(CC-4047).html","C13H11N3O4","free base","CC-4047","NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",{"v":-0.65,"d":"-0.650"},4,2,1]
["S1568","PD318088","g4","L3000-05","in 10mM DMSO","MEK","MAPK","PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.",561.09,"391210-00-7",{"v":112,"d":"112.00"},199.61,"<1","N/A","http://selleckchem.com/products/PD318088.html","C16H13BrF3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C(=C1)Br)F",3.327,2,4,7]
["S1569","Tazarotene","h4","L3000-05","in 10mM DMSO","Retinoid Receptor","Metabolism","Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.",351.46,"118292-40-3",{"v":10,"d":"10.00"},28.45,"<1","N/A","http://selleckchem.com/products/Tazarotene(Avage).html","C21H21NO2S","free base","AGN190168","CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(SCCC3(C)C)C=C2",4.951,3,0,5]
["S1570","KU-60019","a5","L3000-05","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.",547.67,"925701-49-1",{"v":18,"d":"18.00"},32.87,"<1","N/A","http://selleckchem.com/products/KU-60019.html","C30H33N3O5S","free base","N/A","CC1CN(CC(C)O1)CC(=O)NC2=CC3=C(SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6)C=C2",3.818,5,1,5]
["S1572","BS-181 HCl","b5","L3000-05","in 10mM DMSO","CDK","Cell Cycle","BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.",416.99,"1397219-81-6",{"v":83,"d":"83.00"},199.05,{"v":3,"d":"3.00"},7.19,"http://selleckchem.com/products/BS-181.html","C22H32N6.HCl","Hydrochloride","N/A","Cl.CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)[N]2N=C1",4.684,2,3,11]
["S1573","Fasudil (HA-1077) HCl","c5","L3000-05","in 10mM DMSO","Autophagy,Calcium Channel,MLCK,PKA,PKC,PKG,Rho,ROCK","Cell Cycle","Fasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.",327.83,"105628-07-7",{"v":5,"d":"5.00"},15.25,{"v":65,"d":"65.00"},198.27,"http://selleckchem.com/products/Fasudil-HCl(HA-1077).html","C14H17N3O2S.HCl","Hydrochloride","AT-877,HA-1077 HCl","Cl.O=[S](=O)(N1CCCNCC1)C2=C3C=CN=CC3=CC=C2",{"v":0.57,"d":"0.570"},3,1,2]
["S1574","Doramapimod (BIRB 796)","d5","L3000-05","in 10mM DMSO","JNK,p38 MAPK,Raf,Src","MAPK","Doramapimod (BIRB 796) is a  pan-p38 MAPK inhibitor with IC50 of  38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2.",527.66,"285983-48-4",{"v":100,"d":"100.00"},189.52,"<1","N/A","http://selleckchem.com/products/BIRB-796-(Doramapimod).html","C31H37N5O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5)C(C)(C)C",5.907,4,2,8]
["S1576","Sulfasalazine (NSC 667219)","e5","L3000-05","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1","N/A","http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1577","Tie2 kinase inhibitor","f5","L3000-05","in 10mM DMSO","Tie-2","Protein Tyrosine Kinase","Tie2 kinase inhibitor is an optimized compound of SB-203580, selective to Tie2 with IC50 of 0.25 μM, 200-fold more potent than p38.",439.53,"948557-43-5",{"v":35,"d":"35.00"},79.63,"<1","N/A","http://selleckchem.com/products/Tie2-kinase-inhibitor.html","C26H21N3O2S","free base","N/A","COC1=CC2=C(C=C1)C=C(C=C2)C3=C(N=C([NH]3)C4=CC=C(C=C4)[S](C)=O)C5=CC=NC=C5",{"v":4.57,"d":"4.570"},4,1,5]
["S1578","Candesartan (CV-11974)","g5","L3000-05","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.",440.45,"139481-59-7",{"v":88,"d":"88.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/Candesartan(Atacand).html","C24H20N6O3","free base","CV-11974","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5)C(=CC=C2)C(O)=O",4.626,6,1,7]
["S1582","H 89 2HCl","h5","L3000-05","in 10mM DMSO","Autophagy,PKA,PKG,S6 Kinase","PI3K/Akt/mTOR","H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM in a cell-free assay, 10-fold selective for PKA than PKG,500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. H 89 2HCl induces autophagy.",519.28,"130964-39-5",{"v":104,"d":"104.00"},200.28,{"v":6,"d":"6.00"},11.55,"http://selleckchem.com/products/H-89-dihydrochloride.html","C20H20BrN3O2S.2HCl","Dihydrochloride","N/A","Cl.Cl.BrC1=CC=C(/C=C/CNCCN[S](=O)(=O)C2=CC=CC3=C2C=CN=C3)C=C1",3.665,3,2,8]
["S1590","TWS119","a6","L3000-05","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.",318.33,"601514-19-6",{"v":64,"d":"64.00"},201.05,"<1","N/A","http://selleckchem.com/products/TWS119.html","C18H14N4O2","free base","N/A","NC1=CC(=CC=C1)C2=CC3=C([NH]2)N=CN=C3OC4=CC=CC(=C4)O",3.464,3,3,3]
["S1591","Bestatin (NK421)","b6","L3000-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bestatin (Ubenimex,NK421) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.",308.37,"58970-76-6",{"v":4,"d":"4.00"},12.97,"<1","N/A","http://www.selleck.cn/products/Ubenimex(Bestatin).html","C16H24N2O4","Free Base","Ubenimex,NK421","CC(C)CC(NC(=O)C(O)C(N)CC1=CC=CC=C1)C(O)=O",{"v":-1.34,"d":"-1.340"},2,3,8]
["S1593","Apixaban (BMS 562247-01)","c6","L3000-05","in 10mM DMSO","Factor Xa","Metabolism","Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.",{"v":459.5,"d":"459.50"},"503612-47-3",{"v":18,"d":"18.00"},39.17,"<1","N/A","http://selleckchem.com/products/Apixaban(BMS-562247-01).html","C25H25N5O4","free base","BMS 562247-01","COC1=CC=C(C=C1)[N]2N=C(C(N)=O)C3=C2C(=O)N(CC3)C4=CC=C(C=C4)N5CCCCC5=O",2.865,5,1,5]
["S1594","Semagacestat (LY450139)","d6","L3000-05","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.",361.44,"425386-60-3",{"v":72,"d":"72.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Semagacestat(LY450139).html","C19H27N3O4","free base","N/A","CC(C)C(O)C(=O)NC(C)C(=O)NC1C(=O)N(C)CCC2=C1C=CC=C2",0.632,3,3,5]
["S1601","Reserpine","e6","L3000-05","in 10mM DMSO","VMAT","Transmembrane Transporters","Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).",608.68,"50-55-5",{"v":13,"d":"13.00"},21.36,"<1","N/A","http://selleckchem.com/products/Reserpine.html","C33H40N2O9","free base","N/A","COC1C(CC2CN3CCC4=C([NH]C5=C4C=CC(=C5)OC)C3CC2C1C(=O)OC)OC(=O)C6=CC(=C(OC)C(=C6)OC)OC",4.242,9,1,10]
["S1603","Furosemide (NSC 269420)","f6","L3000-05","in 10mM DMSO","NKCC","Transmembrane Transporters","Furosemide (NSC 269420) is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.",330.74,"54-31-9",{"v":66,"d":"66.00"},199.55,"<1","N/A","http://selleckchem.com/products/Furosemide(Lasix).html","C12H11ClN2O5S","free base","NSC 269420","N[S](=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O",1.403,4,2,5]
["S1604","Olmesartan Medoxomil","g6","L3000-05","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Olmesartan Medoxomil (CS-866,RNH-6270) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.",558.59,"144689-63-4",{"v":89,"d":"89.00"},159.33,"<1","N/A","http://selleckchem.com/products/olmesartan-medoxomil-Benicar.html","C29H30N6O6","free base","CS-866,RNH-6270","CCCC1=NC(=C([N]1CC2=CC=C(C=C2)C3=CC=CC=C3C4=N[NH]N=N4)C(=O)OCC5=C(C)OC(=O)O5)C(C)(C)O",4.814,9,1,11]
["S1605","Cefdinir","h6","L3000-05","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.",395.41,"91832-40-5",{"v":79,"d":"79.00"},199.79,"<1","N/A","http://selleckchem.com/products/Cefdinir(Omnicef).html","C14H13N5O5S2","free base","FK 482, PD 134393, CI-983","NC1=NC(=CS1)C(=N/O)/C(=O)NC2C3SCC(=C(N3C2=O)C(O)=O)C=C",-0.172,5,2,5]
["S1606","Clotrimazole","a7","L3000-05","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Fungal","Microbiology","Clotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.",344.84,"23593-75-1",{"v":11,"d":"11.00"},{"v":31.9,"d":"31.90"},"<1","N/A","http://selleckchem.com/products/Clotrimazole(Canesten).html","C22H17ClN2","free base","BAY b 5097, FB 5097","ClC1=C(C=CC=C1)C([N]2C=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.222,1,0,4]
["S1607","Rizatriptan Benzoate","b7","L3000-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Rizatriptan Benzoate (MK-462) is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.",391.47,"145202-66-0",{"v":20,"d":"20.00"},51.09,{"v":46,"d":"46.00"},117.51,"http://selleckchem.com/products/Rizatriptan-Benzoate(Maxalt).html","C22H25N5O2","Benzoate","MK-462 Benzoate","CN(C)CCC1=C[NH]C2=C1C=C(C[N]3C=NC=N3)C=C2.OC(=O)C4=CC=CC=C4",0.492,3,1,6]
["S1608","Pyridostigmine Bromide","c7","L3000-05","in 10mM DMSO","AChR","Neuronal Signaling","Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.",261.12,"101-26-8",{"v":52,"d":"52.00"},199.14,{"v":52,"d":"52.00"},199.14,"http://selleckchem.com/products/Pyridostigmine-Bromide(Mestinon).html","C9H13BrN2O2","Bromide","N/A","[Br-].CN(C)C(=O)OC1=C[N+](=CC=C1)C",-1.014,2,0,2]
["S1613","Silodosin","d7","L3000-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Silodosin (KAD 3213, KMD 3213) is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.",495.53,"160970-54-7",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/Silodosin(Rapaflo).html","C25H32F3N3O4","free base","KAD 3213, KMD 3213","CC(CC1=CC2=C(N(CCCO)CC2)C(=C1)C(N)=O)NCCOC3=CC=CC=C3OCC(F)(F)F",3.451,3,3,14]
["S1614","Riluzole (PK 26124)","e7","L3000-05","in 10mM DMSO","GluR,Sodium Channel","Transmembrane Transporters","Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.",{"v":234.2,"d":"234.20"},"1744-22-5",{"v":46,"d":"46.00"},196.41,"<1","N/A","http://selleckchem.com/products/Riluzole(Rilutek).html","C8H5F3N2OS","free base","RP-54274, PK 26124","NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2",3.828,2,1,2]
["S1618","Sulfameter","f7","L3000-05","in 10mM DMSO","Bacterial","Immunology & Inflammation","Sulfameter  is a long-acting sulfonamide antibacterial.",{"v":280.3,"d":"280.30"},"651-06-9",{"v":56,"d":"56.00"},199.79,"<1","N/A","http://selleckchem.com/products/Sulfameter(Bayrena).html","C11H12N4O3S","free base","N/A","COC1=CN=C(N[S](=O)(=O)C2=CC=C(N)C=C2)N=C1",0.297,5,2,4]
["S1622","Prednisone (NSC-10023)","g7","L3000-05","in 10mM DMSO","Glucocorticoid Receptor,Immunology & Inflammation related","Endocrinology & Hormones","Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.",358.43,"53-03-2",{"v":71,"d":"71.00"},198.09,"<1","N/A","http://selleckchem.com/products/Prednisone.html","C21H26O5","free base","Adasone,NSC-10023","CC12CC(=O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO",1.217,3,1,2]
["S1625","Ethinyl Estradiol","h7","L3000-05","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.",{"v":296.4,"d":"296.40"},"57-63-6",{"v":59,"d":"59.00"},199.06,"<1","N/A","http://selleckchem.com/products/Ethinyl-Estradiol.html","C20H24O2","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2(O)C#C",4.886,0,1,0]
["S1626","Naproxen Sodium","a8","L3000-05","in 10mM DMSO","COX","Neuronal Signaling","Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.",252.24,"26159-34-2",{"v":3,"d":"3.00"},11.89,{"v":50,"d":"50.00"},198.22,"http://selleckchem.com/products/Naproxen-Sodium(Aleve).html","C14H13NaO3","Sodium Salt","RS-3650","[Na+].COC1=CC=C2C=C(C=CC2=C1)C(C)C([O-])=O",1.375,1,0,3]
["S1627","Nitazoxanide (NSC 697855)","b8","L3000-05","in 10mM DMSO","Autophagy,Influenza Virus,mTOR,Serotonin Transporter","Microbiology","Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.",307.28,"55981-09-4",{"v":62,"d":"62.00"},201.77,"<1","N/A","http://selleckchem.com/products/Nitazoxanide(Alinia).html","C12H9N3O5S","free base","NTZ, NSC 697855","CC(=O)OC1=C(C=CC=C1)C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.398,4,1,5]
["S1628","Triamcinolone Acetonide","c8","L3000-05","in 10mM DMSO","Glucocorticoid Receptor","Metabolism","Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.",{"v":434.5,"d":"434.50"},"76-25-5",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/Triamcinolone-Acetonide.html","C24H31FO6","free base","N/A","CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CO",1.157,4,2,2]
["S1629","Orlistat (Ro 18-0647)","d8","L3000-05","in 10mM DMSO","Apoptosis related,Fatty Acid Synthase,Lipase","Metabolism","Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.",495.73,"96829-58-2",{"v":99,"d":"99.00"},199.71,"<1","N/A","http://selleckchem.com/products/Orlistat(Alli).html","C29H53NO5","free base","Tetrahydrolipstatin,Ro 18-0647","CCCCCCCCCCCC(CC1OC(=O)C1CCCCCC)OC(=O)C(CC(C)C)NC=O",8.333,5,1,23]
["S1630","Allopurinol","e8","L3000-05","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.",136.11,"315-30-0",{"v":27,"d":"27.00"},198.37,{"v":4,"d":"4.00"},29.39,"http://selleckchem.com/products/Allopurinol(Zyloprim).html","C5H4N4O","Free Base","N/A","O=C1N=CN=C2NNC=C12",-2.125,3,2,0]
["S1631","Allopurinol Sodium","f8","L3000-05","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol Sodium  is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.",{"v":159.1,"d":"159.10"},"17795-21-0",{"v":32,"d":"32.00"},201.13,{"v":32,"d":"32.00"},201.13,"http://selleckchem.com/products/Allopurinol-Sodium(Aloprim).html","C5H4N4NaO","Sodium Salt","N/A","[Na+].O=C1NC=NC2=C1C=N[NH]2",-0.681,3,2,0]
["S1633","Zafirlukast (ICI-204219)","g8","L3000-05","in 10mM DMSO","LTR","Immunology & Inflammation","Zafirlukast (ICI-204219) is an oral leukotriene receptor antagonist (LTRA), used to prevent asthma symptoms.",575.68,"107753-78-6",{"v":100,"d":"100.00"},173.71,"<1","N/A","http://selleckchem.com/products/Zafirlukast(Accolate).html","C31H33N3O6S","free base","ICI-204219","COC1=CC(=CC=C1CC2=C[N](C)C3=C2C=C(NC(=O)OC4CCCC4)C=C3)C(=O)N[S](=O)(=O)C5=CC=CC=C5C",6.299,6,2,9]
["S1635","Erythromycin","h8","L3000-05","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture","Microbiology","Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).",733.93,"114-07-8",{"v":147,"d":"147.00"},200.29,{"v":3,"d":"3.00"},4.09,"http://selleckchem.com/products/Erythromycin(E-Mycin).html","C37H67NO13","Free Base","E-Mycin","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O",1.792,8,3,7]
["S1638","Ibuprofen (NSC 256857)","a9","L3000-05","in 10mM DMSO","COX","Neuronal Signaling","Ibuprofen (NSC 256857, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.",206.28,"15687-27-1",{"v":41,"d":"41.00"},198.76,"<1","N/A","http://selleckchem.com/products/Ibuprofen(Advil).html","C13H18O2","free base","Dolgesic,NSC 256857","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S1639","Amprenavir (VX-478)","b9","L3000-05","in 10mM DMSO","HIV Protease","Proteases","Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.",505.63,"161814-49-9",{"v":16,"d":"16.00"},31.64,"<1","N/A","http://selleckchem.com/products/Amprenavir-(Agenerase).html","C25H35N3O6S","free base","141W94, VX-478, KVX-478","CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)[S](=O)(=O)C3=CC=C(N)C=C3",2.429,5,3,12]
["S1640","Albendazole (SKF-62979)","c9","L3000-05","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.",265.33,"54965-21-8",{"v":17,"d":"17.00"},64.07,"<1","N/A","http://selleckchem.com/products/Albendazole(Albenza).html","C12H15N3O2S","free base","SKF-62979","CCCSC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",3.065,3,2,5]
["S1641","Chlorothiazide","d9","L3000-05","in 10mM DMSO","Others","Others","Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)",295.72,"58-94-6",{"v":59,"d":"59.00"},199.51,"<1","N/A","http://selleckchem.com/products/Chlorothiazide(Diuril).html","C7H6ClN3O4S2","free base","N/A","N[S](=O)(=O)C1=C(Cl)C=C2N=CN[S](=O)(=O)C2=C1",-0.177,5,2,1]
["S1643","Ursodiol","e9","L3000-05","in 10mM DMSO","FXR","GPCR & G Protein","Ursodiol (Ursodeoxycholic acid, UDCA) reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)",392.57,"128-13-2",{"v":79,"d":"79.00"},201.24,"<1","N/A","http://selleckchem.com/products/Ursodiol(Actigal).html","C24H40O4","free base","Ursodeoxycholic acid, UDCA","CC(CCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",4.014,1,2,4]
["S1644","Nitrofural","f9","L3000-05","in 10mM DMSO","Anti-infection","Microbiology","Nitrofural (Nitrofurazone) is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)",198.14,"59-87-0",{"v":40,"d":"40.00"},201.88,"<1","N/A","http://selleckchem.com/products/Nitrofurazone(ACTIN-N).html","C6H6N4O4","free base","Nitrofurazone","NC(=O)N/N=C/C1=CC=C(O1)[N+]([O-])=O",0.223,3,2,3]
["S1645","Ketoprofen","g9","L3000-05","in 10mM DMSO","COX","Neuronal Signaling","Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.",254.28,"22071-15-4",{"v":51,"d":"51.00"},200.57,"<1","N/A","http://selleckchem.com/products/Ketoprofen(Actron).html","C16H14O3","free base","RP-19583","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S1647","Adenosine","h9","L3000-05","in 10mM DMSO","Adenosine Receptor,Nucleoside Analog/Antimetabolite","GPCR & G Protein","Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.",267.24,"58-61-7",{"v":12,"d":"12.00"},{"v":44.9,"d":"44.90"},"<1","N/A","http://selleckchem.com/products/Adenosine(Adenocard).html","C10H13N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-1.881,4,4,2]
["S1649","Zolmitriptan","a10","L3000-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Zolmitriptan(BW-311C90) is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.",287.36,"139264-17-8",{"v":58,"d":"58.00"},201.84,"<1","N/A","http://selleckchem.com/products/Zolmitriptan(Zomig).html","C16H21N3O2","free base","BW-311C90","CN(C)CCC1=C[NH]C2=C1C=C(CC3COC(=O)N3)C=C2",2.457,2,2,5]
["S1651","Telbivudine","b10","L3000-05","in 10mM DMSO","Reverse Transcriptase","Microbiology","Telbivudine(NV 02B) is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.",242.23,"3424-98-4",{"v":48,"d":"48.00"},198.16,{"v":48,"d":"48.00"},198.16,"http://selleckchem.com/products/Telbivudine(Sebivo).html","C10H14N2O5","free base","NV 02B","CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O",-1.238,3,3,2]
["S1652","Monobenzone","c10","L3000-05","in 10mM DMSO","Tyrosinase","Proteases","Monobenzone(Benoquin) is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.",200.23,"103-16-2",{"v":40,"d":"40.00"},199.77,"<1","N/A","http://selleckchem.com/products/Monobenzone(Benoquin).html","C13H12O2","free base","Benoquin","OC1=CC=C(OCC2=CC=CC=C2)C=C1",3.155,1,1,3]
["S1653","Tretinoin (NSC 122758)","d10","L3000-05","in 10mM DMSO","Retinoid Receptor","Metabolism","Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.",{"v":300.4,"d":"300.40"},"302-79-4",{"v":60,"d":"60.00"},199.73,"<1","N/A","http://selleckchem.com/products/Tretinoin(Aberela).html","C20H28O2","free base","Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1654","Phenylbutazone","e10","L3000-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.",308.37,"50-33-9",{"v":62,"d":"62.00"},201.06,"<1","N/A","http://selleckchem.com/products/Phenylbutazone(Butazolidin).html","C19H20N2O2","free base","Butazolidine","CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3",3.954,2,0,5]
["S1655","Ezetimibe (SCH-58235)","f10","L3000-05","in 10mM DMSO","LDL","Metabolism","Ezetimibe (SCH-58235) is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.",{"v":409.4,"d":"409.40"},"163222-33-1",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/Ezetimibe(Zetia).html","C24H21F2NO3","free base","SCH-58235","OC(CCC1C(N(C1=O)C2=CC=C(F)C=C2)C3=CC=C(O)C=C3)C4=CC=C(F)C=C4",4.633,1,2,6]
["S1658","Dofetilide","g10","L3000-05","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.",441.56,"115256-11-6",{"v":88,"d":"88.00"},199.29,"<1","N/A","http://selleckchem.com/products/Dofetilide(Tikosyn).html","C19H27N3O5S2","free base","UK-68798","CN(CCOC1=CC=C(N[S](C)(=O)=O)C=C1)CCC2=CC=C(N[S](C)(=O)=O)C=C2",1.679,5,2,11]
["S1665","Estrone","h10","L3000-05","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estrone is an estrogenic hormone.",270.37,"53-16-7",{"v":54,"d":"54.00"},199.73,"<1","N/A","http://selleckchem.com/products/Estrone.html","C18H22O2","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2=O",3.938,1,1,0]
["S1666","Flucytosine","a11","L3000-05","in 10mM DMSO","Fungal","Microbiology","Flucytosine (5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915) is an antifungal drug with IC50 of 0.93 μM in C. albicans.",129.09,"2022-85-7",{"v":8,"d":"8.00"},61.97,{"v":5,"d":"5.00"},38.73,"http://selleckchem.com/products/Flucytosine(Ancobon).html","C4H4FN3O","free base","5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915","NC1=NC(=O)NC=C1F",-1.048,2,2,0]
["S1667","Trichlormethiazide","b11","L3000-05","in 10mM DMSO","Others","Others","Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide.",380.66,"133-67-5",{"v":54,"d":"54.00"},141.86,"<1","N/A","http://selleckchem.com/products/Trichlormethiazide(Achletin).html","C8H8Cl3N3O4S2","free base","N/A","N[S](=O)(=O)C1=C(Cl)C=C2NC(N[S](=O)(=O)C2=C1)C(Cl)Cl",1.046,4,3,2]
["S1679","Flurbiprofen","c11","L3000-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).",244.26,"5104-49-4",{"v":49,"d":"49.00"},200.61,"<1","N/A","http://selleckchem.com/products/Flurbiprofen(Ansaid).html","C15H13FO2","free base","N/A","CC(C(O)=O)C1=CC(=C(C=C1)C2=CC=CC=C2)F",{"v":3.68,"d":"3.680"},1,0,3]
["S1680","Disulfiram (NSC 190940)","d11","L3000-05","in 10mM DMSO","Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis","Metabolism","Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).",296.54,"97-77-8",{"v":59,"d":"59.00"},198.96,"<1","N/A","http://selleckchem.com/products/Disulfiram(Antabuse).html","C10H20N2S4","free base","NSC 190940, Tetraethylthiuram disulfide, TETD","CCN(CC)C(=S)SSC(=S)N(CC)CC",{"v":5.6,"d":"5.600"},0,0,9]
["S1681","Mesalamine (5-ASA)","e11","L3000-05","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK","NF-κB","Mesalamine (5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.",153.14,"89-57-6",{"v":31,"d":"31.00"},202.43,"<1","N/A","http://selleckchem.com/products/Mesalamine(Lialda).html","C7H7NO3","free base","5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa","NC1=CC=C(O)C(=C1)C(O)=O",0.471,1,2,1]
["S1683","Ipratropium Bromide","f11","L3000-05","in 10mM DMSO","AChR","Neuronal Signaling","Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).",412.37,"22254-24-6",{"v":83,"d":"83.00"},201.28,{"v":83,"d":"83.00"},201.28,"http://selleckchem.com/products/Ipratropium-bromide.html","C20H30BrNO3","Bromide","N/A","[Br-].CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",-1.326,2,1,6]
["S1685","Sulfanilamide","g11","L3000-05","in 10mM DMSO","Bacterial","Microbiology","Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.",{"v":172.2,"d":"172.20"},"63-74-1",{"v":34,"d":"34.00"},197.44,"<1","N/A","http://selleckchem.com/products/Sulfanilamide.html","C6H8N2O2S","free base","N/A","NC1=CC=C(C=C1)[S](N)(=O)=O",-0.212,2,2,1]
["S1688","Betamethasone Dipropionate","h11","L3000-05","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.",504.59,"5593-20-4",{"v":100,"d":"100.00"},198.18,"<1","N/A","http://selleckchem.com/products/Betamethasone-Dipropionate(Diprolene).html","C28H37FO7","Free Base","SCH 11460","CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C",{"v":3.8,"d":"3.800"},6,1,8]
["S1689","Meprednisone","a2","L3000-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.",372.46,"1247-42-3",{"v":75,"d":"75.00"},201.37,"<1","N/A","http://selleckchem.com/products/Betapar(Meprednisone).html","C22H28O5","free base","NSC 527579, SCH 4358","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC2(C)C1(O)C(=O)CO",1.536,3,1,2]
["S1690","Betamethasone Valerate","b2","L3000-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.",476.58,"2152-44-5",{"v":95,"d":"95.00"},199.34,"<1","N/A","http://selleckchem.com/products/Betamethasone-valerate(Betnovate).html","C27H37FO6","free base","N/A","CCCCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CO",3.666,4,2,7]
["S1692","Busulfan (NSC-750)","c2","L3000-06","in 10mM DMSO","Apoptosis related,DNA alkylator","DNA Damage/DNA Repair","Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.",{"v":246.3,"d":"246.30"},"55-98-1",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/Busulfan(Busulfex).html","C6H14O6S2","free base","NSC-750","C[S](=O)(=O)OCCCCO[S](C)(=O)=O",-0.289,2,0,7]
["S1693","Carbamazepine","d2","L3000-06","in 10mM DMSO","Autophagy,Sodium Channel","Transmembrane Transporters","Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.",236.27,"298-46-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/Carbamazepine(Carbatrol).html","C15H12N2O","free base","NSC 169864","NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",2.679,1,1,0]
["S1696","Hydrocortisone (NSC 10483)","e2","L3000-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.",362.46,"50-23-7",{"v":73,"d":"73.00"},{"v":201.4,"d":"201.40"},"<1","N/A","http://selleckchem.com/products/Hydrocortisone.html","C21H30O5","free base","Cortisol","CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)CO)C4(C)CC(O)C23",1.283,2,2,2]
["S1701","Desonide","f2","L3000-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Desonide is a low potency topical corticosteroid.",416.51,"638-94-8",{"v":83,"d":"83.00"},199.27,"<1","N/A","http://selleckchem.com/products/Desonide.html","C24H32O6","free base","N/A","CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(O1)C(=O)CO",1.028,4,2,2]
["S1702","Didanosine","g2","L3000-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.",236.23,"69655-05-6",{"v":47,"d":"47.00"},198.96,"<1","N/A","http://selleckchem.com/products/Didanosine(Videx).html","C10H12N4O3","free base","N/A","OCC1CCC(O1)[N]2C=NC3=C2N=CNC3=O",-0.844,4,2,2]
["S1705","Progesterone (NSC 9704)","h2","L3000-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.",314.46,"57-83-0",{"v":22,"d":"22.00"},69.96,"<1","N/A","http://selleckchem.com/products/Progesterone(Prometrium).html","C21H30O2","free base","NSC 64377, Pregn-4-ene-3,20-dione,NSC 9704","CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",{"v":3.86,"d":"3.860"},2,0,1]
["S1706","Lamivudine (BCH-189)","a3","L3000-06","in 10mM DMSO","COVID-19,Reverse Transcriptase","Microbiology","Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.",229.26,"134678-17-4",{"v":46,"d":"46.00"},200.65,{"v":46,"d":"46.00"},200.65,"http://selleckchem.com/products/Lamivudine(Epivir).html","C8H11N3O3S","free base","GR109714X, BCH-189","NC1=NC(=O)N(C=C1)C2CSC(CO)O2",{"v":-0.59,"d":"-0.590"},3,2,2]
["S1709","Estradiol","b3","L3000-06","in 10mM DMSO","Estrogen/progestogen Receptor,Interleukins","Endocrinology & Hormones","Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.",272.38,"50-28-2",{"v":54,"d":"54.00"},198.25,"<1","N/A","http://selleckchem.com/products/Estradiol.html","C18H24O2","free base","17β-estradiol, β-Estradiol, E2, 17β-Oestradiol","CC12CCC3C(CCC4=C3C=CC(=C4)O)C1CCC2O",3.838,0,2,0]
["S1712","Deferasirox (ICL-670)","c3","L3000-06","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17)","Proteases","Deferasirox (ICL-670, CGP-72670) is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.",373.36,"201530-41-8",{"v":74,"d":"74.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Deferasirox(Exjade).html","C21H15N3O4","free base","CGP-72670, ICL-670","OC(=O)C1=CC=C(C=C1)[N]2N=C(N=C2C3=CC=CC=C3O)C4=CC=CC=C4O",4.063,3,2,4]
["S1713","Piroxicam","d3","L3000-06","in 10mM DMSO","COX","Neuronal Signaling","Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.",331.35,"36322-90-4",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/Piroxicam(Feldene).html","C15H13N3O4S","free base","CP 16171","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.501,4,2,2]
["S1714","Gemcitabine (LY-188011)","e3","L3000-06","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.",{"v":263.2,"d":"263.20"},"95058-81-4",{"v":52,"d":"52.00"},197.57,{"v":52,"d":"52.00"},197.57,"http://selleckchem.com/products/Gemcitabine(Gemzar).html","C9H11F2N3O4","Free Base","LY-188011, NSC 613327","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.394,3,3,2]
["S1715","Glipizide","f3","L3000-06","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glipizide (CP-28720,K 4024) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.",445.54,"29094-61-9",{"v":89,"d":"89.00"},199.76,"<1","N/A","http://selleckchem.com/products/Glipizide(Glucotrol).html","C21H27N5O4S","free base","CP-28720,K 4024","CC1=NC=C(N=C1)C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCCCC3",1.902,6,3,7]
["S1718","Adefovir Dipivoxil (GS 0840)","g3","L3000-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).",501.47,"142340-99-6",{"v":100,"d":"100.00"},199.41,"<1","N/A","http://selleckchem.com/products/Adefovir-Dipivoxil(Preveon).html","C20H32N5O8P","free base","GS 0840","CC(C)(C)C(=O)OCO[P](=O)(COCC[N]1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C",1.666,10,1,15]
["S1721","Azathioprine","h3","L3000-06","in 10mM DMSO","Rho","Cell Cycle","Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.",277.26,"446-86-6",{"v":54,"d":"54.00"},194.76,"<1","N/A","http://selleckchem.com/products/Azathioprine(Azasan).html","C9H7N7O2S","free base","BW 57-322","C[N]1C=NC(=C1SC2=C3[NH]C=NC3=NC=N2)[N+]([O-])=O",1.071,4,1,3]
["S1723","Indomethacin (NSC-77541)","a4","L3000-06","in 10mM DMSO","COX","Neuronal Signaling","Indomethacin (NSC-77541, Indometacin) is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.",357.79,"53-86-1",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/Indomethacin(Indocid).html","C19H16ClNO4","free base","Indometacin,NSC-77541","COC1=CC=C2[N](C(=C(CC(O)=O)C2=C1)C)C(=O)C3=CC=C(Cl)C=C3",4.235,3,0,4]
["S1727","Levonorgestrel","b4","L3000-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.",312.45,"797-63-7",{"v":45,"d":"45.00"},144.02,"<1","N/A","http://selleckchem.com/products/Levonorgestrel(Levonelle).html","C21H28O2","free base","D-Norgestrel","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S1729","Gemfibrozil","c4","L3000-06","in 10mM DMSO","PPAR","Metabolism","Gemfibrozil (CI-719) is an activator of peroxisome proliferator-activated receptor-alpha (PPARα), used for the treatment of hypercholesterolemia and hypertriglyceridemia.",250.33,"25812-30-0",{"v":50,"d":"50.00"},199.74,"<1","N/A","http://selleckchem.com/products/Gemfibrozil(Lopid).html","C15H22O3","free base","CI-719","CC1=CC(=C(C)C=C1)OCCCC(C)(C)C(O)=O",4.172,2,0,6]
["S1730","Indapamide","d4","L3000-06","in 10mM DMSO","Others","Others","Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.",365.83,"26807-65-8",{"v":73,"d":"73.00"},199.55,"<1","N/A","http://selleckchem.com/products/Indapamide(Lozol).html","C16H16ClN3O3S","free base","N/A","CC1CC2=C(C=CC=C2)N1NC(=O)C3=CC=C(Cl)C(=C3)[S](N)(=O)=O",2.664,3,2,3]
["S1732","Mitotane","e4","L3000-06","in 10mM DMSO","Others","Others","Mitotane (NCI-C04933), is an antineoplastic medication used in the treatment of adrenocortical carcinoma.",320.04,"53-19-0",{"v":64,"d":"64.00"},199.98,"<1","N/A","http://selleckchem.com/products/Mitotane(Lysodren).html","C14H10Cl4","free base","NCI-C04933","ClC(Cl)C(C1=CC=C(Cl)C=C1)C2=C(Cl)C=CC=C2",5.745,0,0,3]
["S1733","Methylprednisolone (NSC-19987)","f4","L3000-06","in 10mM DMSO","ACE,Apoptosis related,Autophagy,Glucocorticoid Receptor,Immunology & Inflammation related,Interleukins","Endocrinology & Hormones","Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.",374.47,"83-43-2",{"v":75,"d":"75.00"},200.28,"<1","N/A","http://selleckchem.com/products/Methylprednisolone.html","C22H30O5","free base","NSC-19987,U 7532","CC1CC2C3CCC(O)(C(=O)CO)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",1.512,2,2,2]
["S1734","Meloxicam","g4","L3000-06","in 10mM DMSO","COX","Neuronal Signaling","Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.",{"v":351.4,"d":"351.40"},"71125-38-7",{"v":30,"d":"30.00"},85.37,"<1","N/A","http://selleckchem.com/products/Meloxicam(Mobic).html","C14H13N3O4S2","free base","N/A","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=C(C)S3",0.255,4,2,2]
["S1735","Mesna","h4","L3000-06","in 10mM DMSO","Others","Others","Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.",164.18,"19767-45-4",{"v":33,"d":"33.00"},{"v":201,"d":"201.00"},{"v":7,"d":"7.00"},42.64,"http://selleckchem.com/products/Mesna(Uromitexan).html","C2H5NaO3S2","Sodium Salt","N/A","[Na+].[O-][S](=O)(=O)CCS",-2.227,0,0,2]
["S1736","Methocarbamol","a5","L3000-06","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.",241.24,"532-03-6",{"v":48,"d":"48.00"},198.97,{"v":2,"d":"2.00"},8.29,"http://selleckchem.com/products/Methocarbamol(Robaxin).html","C11H15NO5","free base","AHR 85","COC1=C(OCC(O)COC(N)=O)C=CC=C1",0.916,4,2,7]
["S1738","Telmisartan","b5","L3000-06","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.",514.62,"144701-48-4",{"v":13,"d":"13.00"},25.26,"<1","N/A","http://selleckchem.com/products/Telmisartan(Micardis).html","C33H30N4O2","free base","BIBR 277","CCCC1=NC2=C(C=C(C=C2C)C3=NC4=C(C=CC=C4)[N]3C)[N]1CC5=CC=C(C=C5)C6=CC=CC=C6C(O)=O",7.799,3,0,7]
["S1739","Thiabendazole","c5","L3000-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property, used as an anthelmintic and fungicide agent. It is a potent inhibitor of  cytochrome P450 1A2 (CYP1A2).",201.25,"148-79-8",{"v":40,"d":"40.00"},198.76,"<1","N/A","http://selleckchem.com/products/Thiabendazole.html","C10H7N3S","free base","N/A","[NH]1C2=C(C=CC=C2)N=C1C3=CSC=N3",2.154,2,1,1]
["S1741","Rifabutin (LM427)","d5","L3000-06","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.",{"v":847,"d":"847.00"},"72559-06-9",{"v":60,"d":"60.00"},70.84,"<1","N/A","http://selleckchem.com/products/Rifabutin(Mycobutin).html","C46H62N4O11","free base","LM427, Ansamycin","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=O)C(=C5NC6(CCN(CC6)CC(C)C)N=C45)NC(=O)/C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C",3.931,9,5,5]
["S1742","Nevirapine (NSC 641530)","e5","L3000-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Nevirapine (NSC 641530,NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.",{"v":266.3,"d":"266.30"},"129618-40-2",{"v":53,"d":"53.00"},199.02,"<1","N/A","http://selleckchem.com/products/Nevirapine(Viramune).html","C15H14N4O","free base","NSC 641530,NVP","CC1=CC=NC2=C1NC(=O)C3=C(N=CC=C3)N2C4CC4",2.293,3,1,1]
["S1747","Nimodipine","f5","L3000-06","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.",418.44,"66085-59-4",{"v":84,"d":"84.00"},200.75,"<1","N/A","http://selleckchem.com/products/Nimodipine(Nimotop).html","C21H26N2O7","free base","BAY E 9736","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C",2.361,5,1,10]
["S1754","Oxybutynin","g5","L3000-06","in 10mM DMSO","AChR","Neuronal Signaling","Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.",357.49,"5633-20-5",{"v":71,"d":"71.00"},198.61,"<1","N/A","http://selleckchem.com/products/Oxybutynin(Ditropan).html","C22H31NO3","Free Base","N/A","CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C2=CC=CC=C2",4.646,2,0,10]
["S1756","Enoxacin","h5","L3000-06","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Enoxacin (AT-2266, CI919, Pd107779, NSC 629661) is an oral broad-spectrum fluoroquinolone antibacterial agent by inhibiting bacterial DNA gyrase and topoisomerase IV, used to treat a wide variety of infections.",320.32,"74011-58-8",{"v":32,"d":"32.00"},{"v":99.9,"d":"99.90"},"<1","N/A","http://selleckchem.com/products/Enoxacin(Penetrex).html","C15H17FN4O3","free base","AT-2266, CI919, Pd107779, NSC 629661","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(N=C12)N3CCNCC3)F",-1.483,3,1,3]
["S1759","Pitavastatin (NK-104) calcium","a6","L3000-06","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1760","Rifapentine","b6","L3000-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.",877.03,"61379-65-5",{"v":100,"d":"100.00"},114.02,"<1","N/A","http://selleckchem.com/products/Rifapentine(Priftin).html","C47H64N4O12","free base","MDL473","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(CC5)C6CCCC6",4.664,8,6,6]
["S1761","Suprofen","c6","L3000-06","in 10mM DMSO","COX","Neuronal Signaling","Suprofen(TN-762) is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.",260.31,"40828-46-4",{"v":52,"d":"52.00"},199.76,"<1","N/A","http://selleckchem.com/products/Suprofen(Profenal).html","C14H12O3S","free base","TN-762","CC(C(O)=O)C1=CC=C(C=C1)C(=O)C2=CC=CS2",3.314,2,0,4]
["S1763","Quetiapine (ICI-204636) fumarate","d6","L3000-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Quetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.",883.09,"111974-72-2",{"v":36,"d":"36.00"},40.77,"<1","N/A","http://selleckchem.com/products/Quetiapine-fumarate(Seroquel).html","C46H54N6O8S2","Fumarate","ICI-204636 fumarate","OCCOCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=CC=C4.OCCOCCN5CCN(CC5)C6=NC7=CC=CC=C7SC8=C6C=CC=C8.OC(=O)\\C=C\\C(O)=O",-0.718,6,2,14]
["S1764","Rifampin (NSC-113926)","e6","L3000-06","in 10mM DMSO","Antibiotics for Plant Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Rifampin (NSC-113926, Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.",822.94,"13292-46-1",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Rifampin(Rifadin).html","C43H58N4O12","free base","Rimactane, Rifampicin,NSC-113926","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(C)CC5",3.262,8,6,5]
["S1768","Cefditoren Pivoxil","f6","L3000-06","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria.",620.72,"117467-28-4",{"v":100,"d":"100.00"},{"v":161.1,"d":"161.10"},"<1","N/A","http://selleckchem.com/products/Cefditoren-pivoxil.html","C25H28N6O7S3","free base","ME-1207","CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)\\C=C/C3=C(C)N=CS3)C4=CSC(=N4)N",1.926,10,2,12]
["S1770","Sulfadiazine","g6","L3000-06","in 10mM DMSO","Antibiotics","Microbiology","Sulfadiazine is a sulfonamide antibiotic.",250.28,"68-35-9",{"v":50,"d":"50.00"},199.78,"<1","N/A","http://selleckchem.com/products/Sulfadiazine.html","C10H10N4O2S","free base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CC=N2",0.313,4,2,3]
["S1771","Chlorprothixene","h6","L3000-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Chlorprothixene(Minithixen,Truxal) has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.",315.86,"113-59-7",{"v":6,"d":"6.00"},{"v":19,"d":"19.00"},"<1","N/A","http://selleckchem.com/products/Chlorprothixene.html","C18H18ClNS","free base","Minithixen,Truxal","CN(C)CC/C=C1/C2=CC=CC=C2SC3=C1C=C(Cl)C=C3",5.123,0,0,3]
["S1774","Thioguanine (NSC 752)","a7","L3000-06","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1775","Thiotepa","b7","L3000-06","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.",189.22,"52-24-4",{"v":100,"d":"100.00"},528.49,{"v":100,"d":"100.00"},528.49,"http://selleckchem.com/products/thiotepa-thioplex.html","C6H12N3PS","free base","Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide","S=[P](N1CC1)(N2CC2)N3CC3",-0.762,0,0,3]
["S1776","Toremifene Citrate (NK 622)","c7","L3000-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Toremifene Citrate (NK 622, NSC 613680) is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.",598.08,"89778-27-8",{"v":100,"d":"100.00"},{"v":167.2,"d":"167.20"},"<1","N/A","http://selleckchem.com/products/Toremifene-Citrate(Fareston).html","C32H36ClNO8","Citrate","NSC 613680,NK 622 Citrate","CN(C)CCOC1=CC=C(C=C1)\\C(=C(CCCl)/C2=CC=CC=C2)C3=CC=CC=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.945,4,0,14]
["S1777","Ethionamide","d7","L3000-06","in 10mM DMSO","Antibiotics","Microbiology","Ethionamide (Bayer 5312) is an antibiotic used in the treatment of tuberculosis.",166.24,"536-33-4",{"v":33,"d":"33.00"},198.51,"<1","N/A","http://selleckchem.com/products/Ethionamide.html","C8H10N2S","free base","Bayer 5312","CCC1=NC=CC(=C1)C(N)=S",1.498,1,1,2]
["S1778","Trifluridine (NSC 75520)","e7","L3000-06","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.",{"v":296.2,"d":"296.20"},"70-00-8",{"v":59,"d":"59.00"},199.19,{"v":59,"d":"59.00"},199.19,"http://selleckchem.com/products/Trifluridine(Viroptic).html","C10H11F3N2O5","free base","NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT","OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F",-0.782,3,3,3]
["S1782","Azacitidine (5-Azacytidine)","f7","L3000-06","in 10mM DMSO","Autophagy,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.",{"v":244.2,"d":"244.20"},"320-67-2",{"v":48,"d":"48.00"},196.56,"<1","N/A","http://selleckchem.com/products/Azacitidine(Vidaza).html","C8H12N4O5","free base","5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine","NC1=NC(=O)N(C=N1)C2OC(CO)C(O)C2O",-2.505,4,4,2]
["S1784","Vidarabine","g7","L3000-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.",267.24,"5536-17-4",{"v":53,"d":"53.00"},198.32,{"v":3,"d":"3.00"},11.23,"http://selleckchem.com/products/Vidarabine(Vira-A).html","C10H13N5O4","free base","N/A","NC1=C2N=C[N](C3OC(CO)C(O)C3O)C2=NC=N1",-1.881,4,4,2]
["S1786","Verteporfin (CL 318952)","h7","L3000-06","in 10mM DMSO","Apoptosis related,Autophagy,TEAD,VDA,YAP","Angiogenesis","Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.  It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.",718.79,"129497-78-5",{"v":100,"d":"100.00"},139.12,"<1","N/A","http://selleckchem.com/products/Verteporfin(Visudyne).html","C41H42N4O8","free base","CL 318952, Visudyne","COC(=O)CCC1=C(C)C2=CC3=NC(=CC4=C(C)C(=C([NH]4)C=C5N=C(C=C1[NH]2)C(=C5C)CCC(O)=O)C=C)C6=CC=C(C(C(=O)OC)C36C)C(=O)OC",7.789,9,2,12]
["S1787","Teniposide","a8","L3000-06","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Teniposide (NSC 122819, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).",656.65,"29767-20-2",{"v":40,"d":"40.00"},60.92,"<1","N/A","http://selleckchem.com/products/Teniposide(Vumon).html","C32H32O13S","free base","NSC 122819, VM-26","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(OC5C(O)C4O)C6=CC=CS6)C7=CC8=C(OCO8)C=C27",2.516,10,3,6]
["S1790","Rifaximin","b8","L3000-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.",785.88,"80621-81-4",{"v":47,"d":"47.00"},59.81,"<1","N/A","http://selleckchem.com/products/Rifaximin(Xifaxan).html","C43H51N3O11","free base","N/A","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=C(NC(=O)\\C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C5=C4N=C6C=C(C)C=C[N]56)O",4.805,8,5,3]
["S1792","Simvastatin (MK 733)","c8","L3000-06","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1793","Ramipril","d8","L3000-06","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Ramipril(HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.",416.51,"87333-19-5",{"v":83,"d":"83.00"},199.27,"<1","N/A","http://selleckchem.com/products/Ramipril(Altace).html","C23H32N2O5","free base","HOE-498","CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(O)=O",0.308,4,1,10]
["S1794","Fenofibrate (NSC-281319)","e8","L3000-06","in 10mM DMSO","Autophagy,P450 (e.g. CYP17),PPAR","Metabolism","Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.",360.83,"49562-28-9",{"v":72,"d":"72.00"},199.54,"<1","N/A","http://selleckchem.com/products/Fenofibrate(Tricor).html","C20H21ClO4","free base","NSC-281319","CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2",5.111,4,0,7]
["S1799","Ranolazine","f8","L3000-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine (CVT 303, RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.",427.54,"95635-55-5",{"v":86,"d":"86.00"},201.15,"<1","N/A","http://selleckchem.com/products/Ranolazine(Ranexa).html","C24H33N3O4","Free Base","CVT 303, RS 43285-003","COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",2.991,3,2,9]
["S1801","Ranitidine Hydrochloride","g8","L3000-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.",350.86,"66357-59-3",{"v":70,"d":"70.00"},199.51,{"v":70,"d":"70.00"},199.51,"http://selleckchem.com/products/Ranitidine-hydrochloride(Zantac).html","C13H22N4O3S.HCl","Hydrochloride","AH19065","Cl.CNC(/NCCSCC1=CC=C(CN(C)C)O1)=C\\[N+]([O-])=O",1.421,1,2,10]
["S1802","AICAR (Acadesine)","h8","L3000-06","in 10mM DMSO","AMPK,Mitophagy","PI3K/Akt/mTOR","AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.",258.23,"2627-69-2",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Acadesine.html","C9H14N4O5","free base","NSC105823, AICA Riboside","NC(=O)C1=C(N)[N](C=N1)C2OC(CO)C(O)C2O",-2.913,3,5,3]
["S1805","Acetylcholine Chloride","a9","L3000-06","in 10mM DMSO","AChR","Neuronal Signaling","The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.",181.66,"60-31-1",{"v":36,"d":"36.00"},198.17,{"v":36,"d":"36.00"},198.17,"http://www.selleck.cn/products/Acetylcholine-chloride.html","C7H16NO2.Cl","Chloride","ACh chloride","[Cl-].CC(=O)OCC[N+](C)(C)C",-3.869,2,0,4]
["S1806","Acipimox","b9","L3000-06","in 10mM DMSO","Others","Others","Acipimox (Olbemox,K-9321) is a niacin derivative used as a hypolipidemic agent.",154.12,"51037-30-0",{"v":31,"d":"31.00"},201.14,"<1","N/A","http://selleckchem.com/products/Acipimox.html","C6H6N2O3","free base","Olbemox,K-9321","CC1=CN=C(C=[N+]1[O-])C(O)=O",-0.975,2,0,1]
["S1808","Nifedipine (BAY-a-1040)","c9","L3000-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.",346.33,"21829-25-4",{"v":69,"d":"69.00"},199.23,"<1","N/A","http://selleckchem.com/products/Nifedipine(Adalat).html","C17H18N2O6","free base","BAY-a-1040","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC)C",1.766,4,1,6]
["S1811","Amiloride (MK-870) HCl","d9","L3000-06","in 10mM DMSO","Calcium Channel,Serine Protease,Sodium Channel","Transmembrane Transporters","Amiloride (MK-870 HCl) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).",266.09,"2016-88-8",{"v":53,"d":"53.00"},199.18,{"v":6,"d":"6.00"},22.55,"http://selleckchem.com/products/Amiloride-hydrochloride(Midamor).html","C6H8ClN7O.HCl","Hydrochloride","MK-870 HCl","Cl.NC(=N)NC(=O)C1=NC(=C(N)N=C1N)Cl",-0.366,3,4,2]
["S1816","Chlorpheniramine Maleate","e9","L3000-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Chlorpheniramine Maleate (Chlorpheniramine maleate, Chlorphenamine, NCI-C55265) is an histamine H1 receptor antagonist with IC50 of 12 nM.",390.86,"113-92-8",{"v":78,"d":"78.00"},199.56,{"v":78,"d":"78.00"},199.56,"http://selleckchem.com/products/Chlorpheniramine-maleate.html","C16H19ClN2.C4H4O4","Maleate","NCI-C55265","CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":0.7,"d":"0.700"},3,0,7]
["S1820","Clofibrate","f9","L3000-06","in 10mM DMSO","Others","Others","Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.",{"v":242.7,"d":"242.70"},"637-07-0",{"v":7,"d":"7.00"},28.84,"<1","N/A","http://www.selleck.cn/products/Clofibrate(Atromid-S).html","C12H15ClO3","Free Base","N/A","CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1",3.329,3,0,5]
["S1827","Betaxolol HCl","g9","L3000-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM.",343.89,"63659-19-8",{"v":69,"d":"69.00"},200.65,{"v":69,"d":"69.00"},200.65,"http://selleckchem.com/products/betaxolol-hydrochloride-betoptic.html","C18H29NO3.HCl","Hydrochloride","SL 75212 HCl","Cl.CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1",2.959,2,2,11]
["S1828","Proparacaine HCl","h9","L3000-06","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.",330.85,"5875-06-9",{"v":12,"d":"12.00"},36.27,{"v":66,"d":"66.00"},199.49,"http://selleckchem.com/products/proparacaine-hcl.html","C16H26N2O3.HCl","Hydrochloride","Proxymetacaine Hydrochloride","Cl.CCCOC1=C(N)C=C(C=C1)C(=O)OCCN(CC)CC",3.013,3,1,10]
["S1829","Pranlukast","a10","L3000-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.",{"v":481.5,"d":"481.50"},"103177-37-3",{"v":11,"d":"11.00"},22.85,"<1","N/A","http://selleckchem.com/products/pranlukast.html","C27H23N5O4","free base","ONO-1078,ono-rs-411","O=C(NC1=CC2=C(C=C1)C(=O)C=C(O2)C3=NN=N[NH]3)C4=CC=C(OCCCCC5=CC=CC=C5)C=C4",4.232,7,2,9]
["S1830","Oxfendazole","b10","L3000-06","in 10mM DMSO","Parasite","Microbiology","Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.",315.35,"53716-50-0",{"v":10,"d":"10.00"},31.71,"<1","N/A","http://selleckchem.com/products/oxfendazole.html","C15H13N3O3S","free base","RS-8858,Fenbendazole sulfoxide","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)[S](=O)C3=CC=CC=C3",2.657,4,2,4]
["S1831","Carvedilol","c10","L3000-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.",406.47,"72956-09-3",{"v":81,"d":"81.00"},199.28,"<1","N/A","http://selleckchem.com/products/carvedilol.html","C24H26N2O4","free base","BM-14190, SKF 105517","COC1=CC=CC=C1OCCNCC(O)COC2=C3C(=CC=C2)[NH]C4=C3C=CC=C4",4.014,3,3,10]
["S1833","Butoconazole nitrate","d10","L3000-06","in 10mM DMSO","Fungal,IFN,Interleukins,TNF-alpha","Microbiology","Butoconazole nitrate (RS-35887) is an anti-fungal agent that inhibits PHA-stimulated release of cytokines-- IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively).",474.79,"64872-77-1",{"v":95,"d":"95.00"},200.09,"<1","N/A","http://selleckchem.com/products/butoconazole-nitrate.html","C19H17Cl3N2S.HNO3","Nitrate","RS-35887","O[N+]([O-])=O.ClC1=CC=C(CCC(C[N]2C=CN=C2)SC3=C(Cl)C=CC=C3Cl)C=C1",5.238,1,0,7]
["S1835","Azithromycin (CP-62993)","e10","L3000-06","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Autophagy,Bacterial,COVID-19","Autophagy","Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.",748.98,"83905-01-5",{"v":100,"d":"100.00"},133.51,"<1","N/A","http://selleckchem.com/products/azithromycin-zithromax.html","C38H72N2O12","Free Base","XZ-450,CP-62993","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",2.078,7,3,7]
["S1839","Chloroxine","f10","L3000-06","in 10mM DMSO","Bacterial","Microbiology","Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.",214.05,"773-76-2",{"v":43,"d":"43.00"},200.89,"<1","N/A","http://selleckchem.com/products/Chloroxine.html","C9H5Cl2NO","free base","N/A","OC1=C(Cl)C=C(Cl)C2=C1N=CC=C2",3.103,1,1,0]
["S1840","Lomustine","g10","L3000-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.",{"v":233.7,"d":"233.70"},"13010-47-4",{"v":46,"d":"46.00"},196.83,"<1","N/A","http://selleckchem.com/products/Lomustine(CeeNU).html","C9H16ClN3O2","free base","NSC79037, Gleostine, CeeNU, CCNU","ClCCN(N=O)C(=O)NC1CCCCC1",2.394,2,1,4]
["S1845","Cimetidine","h10","L3000-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.",252.34,"51481-61-9",{"v":51,"d":"51.00"},202.11,"<1","N/A","http://selleckchem.com/products/Cimetidine(Tagamet).html","C10H16N6S","free base","SKF-92334","CNC(NCCSCC1=C(C)[NH]C=N1)=NC#N",0.007,2,3,7]
["S1847","Clemastine (HS-592) fumarate","a11","L3000-06","in 10mM DMSO","Autophagy,Histamine Receptor,mTOR","Neuronal Signaling","Clemastine Fumarate (HS-592, Meclastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Clemastine stimulates autophagy via mTOR pathway.",459.96,"14976-57-9",{"v":35,"d":"35.00"},76.09,"<1","N/A","http://selleckchem.com/products/Clemastine-Fumarate.html","C21H26ClNO.C4H4O4","Fumarate","HS-592 fumarate, Meclastine fumarate","CN1CCCC1CCOC(C)(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.OC(=O)\\C=C\\C(O)=O",{"v":1.81,"d":"1.810"},3,0,8]
["S1848","Curcumin","b11","L3000-06","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S1849","Daidzein","c11","L3000-06","in 10mM DMSO","PPAR","Metabolism","Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.",254.24,"486-66-8",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Daidzein.html","C15H10O4","free base","N/A","OC1=CC=C(C=C1)C2=COC3=CC(=CC=C3C2=O)O",2.382,2,2,1]
["S1854","Bifonazole","d11","L3000-06","in 10mM DMSO","Fungal","Microbiology","Bifonazole (Bay h 4502,(±)-bifonazole) is a substituted imidazole antifungal agent.",310.39,"60628-96-8",{"v":62,"d":"62.00"},199.75,"<1","N/A","http://selleckchem.com/products/bifonazole.html","C22H18N2","free base","Bay h 4502,(±)-bifonazole","C1=CC=C(C=C1)C([N]2C=CN=C2)C3=CC=C(C=C3)C4=CC=CC=C4",4.637,1,0,4]
["S1855","Pefloxacin Mesylate","e11","L3000-06","in 10mM DMSO","Bacterial","Microbiology","Pefloxacin Mesylate(Pefloxacinium mesylate) is a synthetic chemotherapeutic agent and an antibacterial agent with IC50 of 6.7 nM.",429.46,"70458-95-6",{"v":14,"d":"14.00"},{"v":32.6,"d":"32.60"},{"v":67,"d":"67.00"},156.01,"http://selleckchem.com/products/pefloxacin-mesylate.html","C17H20FN3O3.CH4O3S","Mesylate","Pefloxacinium mesylate","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(C=C12)N3CCN(C)CC3)F.C[S](O)(=O)=O",-1.618,2,0,3]
["S1856","Metoprolol Tartrate","f11","L3000-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.",684.81,"56392-17-7",{"v":100,"d":"100.00"},146.03,{"v":100,"d":"100.00"},146.03,"http://selleckchem.com/products/metoprolol-tartrate.html","2C15H25NO3.C4H6O6","Tartrate","CGP 2175E","COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC2=CC=C(OCC(O)CNC(C)C)C=C2.OC(C(O)C(O)=O)C(O)=O",-3.559,6,6,21]
["S1858","Dienestrol","g11","L3000-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienestrol(Restrol) is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist.",266.33,"84-17-3",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/Dienestrol(Restrol).html","C18H18O2","Free Base","Restrol","C/C=C(C1=CC=C(O)C=C1)/C(=C/C)C2=CC=C(O)C=C2",4.692,0,2,3]
["S1859","Diethylstilbestrol","h11","L3000-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Diethylstilbestrol (Stilbestrol) is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.",268.35,"56-53-1",{"v":54,"d":"54.00"},201.23,"<1","N/A","http://selleckchem.com/products/Diethylstilbestrol(Stilbestrol).html","C18H20O2","free base","Stilbestrol","CCC(/C1=CC=C(O)C=C1)=C(CC)\\C2=CC=C(O)C=C2",5.137,0,2,4]
["S1869","Dapoxetine HCl","a2","L3000-07","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.",341.87,"129938-20-1",{"v":68,"d":"68.00"},198.91,{"v":68,"d":"68.00"},198.91,"http://selleckchem.com/products/Dapoxetine-hydrochloride(Priligy).html","C21H23NO.HCl","Hydrochloride","LY-210448","Cl.CN(C)C(CCOC1=C2C=CC=CC2=CC=C1)C3=CC=CC=C3",4.917,1,0,6]
["S1878","Ganciclovir (BW 759)","b2","L3000-07","in 10mM DMSO","CMV","Microbiology","Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.",255.23,"82410-32-0",{"v":27,"d":"27.00"},105.79,"<1","N/A","http://selleckchem.com/products/ganciclovir.html","C9H13N5O4","free base","RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine","NC1=NC2=C(N=C[N]2COC(CO)CO)C(=O)N1",-1.934,4,4,5]
["S1880","Roxatidine Acetate HCl","c2","L3000-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Roxatidine Acetate HCl(HOE 760) is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.",{"v":384.9,"d":"384.90"},"93793-83-0",{"v":77,"d":"77.00"},200.05,{"v":77,"d":"77.00"},200.05,"http://selleckchem.com/products/roxatidine-acetate-hcl.html","C19H28N2O4.HCl","Hydrochloride","HOE 760","Cl.CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2",2.148,4,1,10]
["S1883","Idoxuridine","d2","L3000-07","in 10mM DMSO","Antiviral","Microbiology","Idoxuridine (NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.",{"v":354.1,"d":"354.10"},"54-42-2",{"v":35,"d":"35.00"},98.84,"<1","N/A","http://selleckchem.com/products/idoxuridine.html","C9H11IN2O5","free base","NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd","OCC1OC(CC1O)N2C=C(I)C(=O)NC2=O",-1.402,3,3,2]
["S1884","Sparfloxacin","e2","L3000-07","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sparfloxacin (AT-4140, CI-978, PD 131501,Zagam) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.",{"v":392.4,"d":"392.40"},"110871-86-8",{"v":9,"d":"9.00"},22.94,"<1","N/A","http://selleckchem.com/products/sparfloxacin.html","C19H22F2N4O3","free base","AT-4140, CI-978, PD 131501,Zagam","CC1CN(CC(C)N1)C2=C(F)C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(O)=O",-1.056,2,2,3]
["S1888","Deflazacort","f2","L3000-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.",441.52,"14484-47-0",{"v":88,"d":"88.00"},199.31,"<1","N/A","http://selleckchem.com/products/Deflazacor.html","C25H31NO6","free base","MDL 458","CC(=O)OCC(=O)C12N=C(C)OC1CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC23C",{"v":1.67,"d":"1.670"},6,1,4]
["S1890","Nizatidine","g2","L3000-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.",331.46,"76963-41-2",{"v":66,"d":"66.00"},199.12,{"v":28,"d":"28.00"},84.47,"http://selleckchem.com/products/Nizatidine(Axid).html","C12H21N5O2S2","free base","N/A","CNC(/NCCSCC1=CSC(=N1)CN(C)C)=C/[N+]([O-])=O",0.643,1,2,10]
["S1894","Valsartan (CGP-48933)","h2","L3000-07","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.",435.52,"137862-53-4",{"v":87,"d":"87.00"},199.76,"<1","N/A","http://selleckchem.com/products/Valsartan(Diovan).html","C24H29N5O3","free base","CGP-48933","CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=N[NH]N=N3)C(C(C)C)C(O)=O",4.538,5,1,10]
["S1895","Dipyridamole (NSC 515776)","a3","L3000-07","in 10mM DMSO","PDE","Metabolism","Dipyridamole (NSC-515776, Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.",504.63,"58-32-2",{"v":101,"d":"101.00"},200.15,"<1","N/A","http://selleckchem.com/products/Dipyridamole(Permole,-Persantine).html","C24H40N8O4","free base","Persantine,NSC-515776","OCCN(CCO)C1=NC2=C(N=C(N=C2N3CCCCC3)N(CCO)CCO)C(=N1)N4CCCCC4",2.483,4,4,12]
["S1896","Hydroxyurea (NSC-32065)","b3","L3000-07","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,HIV","DNA Damage/DNA Repair","Hydroxyurea (NSC-32065, NCI-C04831, Hydroxycarbamide) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.",76.05,"127-07-1",{"v":15,"d":"15.00"},197.24,{"v":15,"d":"15.00"},197.24,"http://selleckchem.com/products/Hydroxyurea(Cytodrox).html","CH4N2O2","free base","NCI-C04831, Hydroxycarbamide,NSC-32065","NC(=O)NO",{"v":-1.03,"d":"-1.030"},1,2,0]
["S1899","Nicotinamide (NSC 13128)","c3","L3000-07","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide (Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.",122.12,"98-92-0",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/Nicotinamide(Niacinamide).html","C6H6N2O","free base","Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128","NC(=O)C1=CC=CN=C1",-0.319,2,1,1]
["S1903","Diclofenac Sodium","d3","L3000-07","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac Sodium (GP 45840) is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.",318.13,"15307-79-6",{"v":64,"d":"64.00"},201.18,{"v":14,"d":"14.00"},44.01,"http://selleckchem.com/products/Diclofenac-sodium.html","C14H10Cl2NNaO2","Sodium Salt","GP 45840","[Na+].[O-]C(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",2.899,0,1,4]
["S1907","Metronidazole","e3","L3000-07","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.",171.15,"443-48-1",{"v":34,"d":"34.00"},198.66,"<1","N/A","http://selleckchem.com/products/Metronidazole(Flagyl).html","C6H9N3O3","free base","N/A","CC1=NC=C([N]1CCO)[N+]([O-])=O",-0.337,1,1,3]
["S1908","Flutamide","f3","L3000-07","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.",276.21,"13311-84-7",{"v":55,"d":"55.00"},199.12,"<1","N/A","http://selleckchem.com/products/Flutamide(Eulexin).html","C11H11F3N2O3","free base","SCH-13521","CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F",2.916,1,1,4]
["S1909","Fluvastatin (XU-62-320) Sodium","g3","L3000-07","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Fluvastatin Sodium (Vastin,XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.",433.45,"93957-55-2",{"v":87,"d":"87.00"},200.72,{"v":1,"d":"1.00"},2.31,"http://selleckchem.com/products/Fluvastatin-Sodium(Lescol).html","C24H25FNNaO4","Sodium","Vastin,XU-62-320","[Na+].CC(C)[N]1C2=C(C=CC=C2)C(=C1\\C=C\\C(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3",{"v":2.77,"d":"2.770"},0,2,8]
["S1910","Tioconazole","h3","L3000-07","in 10mM DMSO","Fungal","Microbiology","Tioconazole (UK-20349) is an antifungal medication with an average IC50 of 1.7 μM.",387.71,"65899-73-2",{"v":78,"d":"78.00"},201.18,"<1","N/A","http://selleckchem.com/products/tioconazole.html","C16H13Cl3N2OS","free base","UK-20349","ClC1=CC=C(C(C[N]2C=CN=C2)OCC3=C(Cl)SC=C3)C(=C1)Cl",4.437,2,0,6]
["S1913","Tropicamide","a4","L3000-07","in 10mM DMSO","AChR","Neuronal Signaling","Tropicamide(Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.",284.35,"1508-75-4",{"v":57,"d":"57.00"},200.46,"<1","N/A","http://selleckchem.com/products/tropicamide.html","C17H20N2O2","free base","Ro 1-7683","CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2",1.432,2,1,6]
["S1914","Pregnenolone","b4","L3000-07","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.",316.48,"145-13-1",{"v":22,"d":"22.00"},69.51,"<1","N/A","http://selleckchem.com/products/pregnenolone.html","C21H32O2","free base","3β-Hydroxy-5-pregnen-20-one","CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C",3.624,1,1,1]
["S1915","Sulfamethoxazole","c4","L3000-07","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sulfamethoxazole(Ro 4-2130) is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.",253.28,"723-46-6",{"v":51,"d":"51.00"},201.36,"<1","N/A","http://selleckchem.com/products/Sulfamethoxazole.html","C10H11N3O3S","free base","Ro 4-2130","CC1=CC(=NO1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.709,4,2,3]
["S1916","Sulfisoxazole","d4","L3000-07","in 10mM DMSO","Bacterial","Microbiology","Sulfisoxazole (NU-445) is a sulfonamide antibacterial with an oxazole substituent.",{"v":267.3,"d":"267.30"},"127-69-5",{"v":53,"d":"53.00"},198.28,"<1","N/A","http://selleckchem.com/products/Sulfisoxazole.html","C11H13N3O3S","free base","NU-445","CC1=NOC(=C1C)N[S](=O)(=O)C2=CC=C(N)C=C2",0.918,4,2,3]
["S1917","Crystal Violet","e4","L3000-07","in 10mM DMSO","Dyes","Others","Crystal violet(Gentian Violet) is a triarylmethane dye.",407.98,"548-62-9",{"v":82,"d":"82.00"},200.99,{"v":14,"d":"14.00"},34.32,"http://selleckchem.com/products/Crystal-violet.html","C25H30ClN3","quaternary-N chloride salt","Gentian Violet","[Cl-].CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)N(C)C)=C3C=CC(C=C3)=[N+](C)C",{"v":2.25,"d":"2.250"},0,0,4]
["S1920","Haloperidol","f4","L3000-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Haloperidol (Haldol) is an antipsychotic and butyrophenone.",375.86,"52-86-8",{"v":75,"d":"75.00"},199.54,"<1","N/A","http://selleckchem.com/products/Haloperidol(Haldol).html","C21H23ClFNO2","free base","N/A","OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3",3.887,1,0,6]
["S1933","Triamcinolone","g4","L3000-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.",394.43,"124-94-7",{"v":78,"d":"78.00"},197.75,"<1","N/A","http://selleckchem.com/products/Triamcinolone(Aristocort).html","C21H27FO6","free base","N/A","CC12CC(O)C3(F)C(CCC4=CC(=O)C=CC34C)C1CC(O)C2(O)C(=O)CO",0.422,2,3,2]
["S1934","Nystatin (Fungicidin)","h4","L3000-07","in 10mM DMSO","Antibiotics for Mammalian Cell Culture,Fungal","Microbiology","Nystatin(Fungicidin), which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.",1056.24,"62997-67-5",{"v":19,"d":"19.00"},17.99,"<1","N/A","http://selleckchem.com/products/Nystatin(Mycostatin).html","C53H85NO20","free base","Fungicidin","CC1OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)CC2(O)CC(O)C(C(CC(OC3OC(C)C(O)C(N)C3O)/C=C/C=C/C=C/C=C/CC/C=C/C=C/C(C)C(O)C1C)O2)C(O)=O",-2.265,8,11,5]
["S1937","Isoniazid","a5","L3000-07","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.",137.14,"54-85-3",{"v":27,"d":"27.00"},196.88,{"v":27,"d":"27.00"},196.88,"http://selleckchem.com/products/Isoniazid(Tubizid).html","C6H7N3O","free base","N/A","NNC(=O)C1=CC=NC=C1",-0.811,2,2,1]
["S1941","Enalapril Maleate","b5","L3000-07","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.",492.52,"76095-16-4",{"v":99,"d":"99.00"},201.01,"<1","N/A","http://selleckchem.com/products/Enalapril-maleate(Vasotec).html","C20H28N2O5.C4H4O4","Maleate","MK-421 Maleate","CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(O)=O.OC(=O)\\C=C/C(O)=O",-0.502,6,1,12]
["S1949","Menadione (NSC 4170)","c5","L3000-07","in 10mM DMSO","CDK,DNA/RNA Synthesis,phosphatase","Metabolism","Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.",172.18,"58-27-5",{"v":34,"d":"34.00"},197.47,"<1","N/A","http://selleckchem.com/products/Menadione.html","C11H8O2","free base","Vitamin K3,NSC 4170","CC1=CC(=O)C2=CC=CC=C2C1=O",2.204,2,0,0]
["S1950","Metformin HCl","d5","L3000-07","in 10mM DMSO","Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK","Metabolism","Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",165.62,"1115-70-4",{"v":33,"d":"33.00"},199.25,{"v":33,"d":"33.00"},199.25,"http://selleckchem.com/products/Metformin-hydrochloride(Glucophage).html","C4H11N5.HCl","Hydrochloride","1,1-Dimethylbiguanide HCl","Cl.CN(C)C(=N)NC(N)=N",{"v":-0.36,"d":"-0.360"},0,2,3]
["S1952","Methoxsalen","e5","L3000-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.",216.19,"298-81-7",{"v":43,"d":"43.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Methoxsalen(Oxsoralen).html","C12H8O4","free base","Xanthotoxin, NCI-C55903","COC1=C2OC=CC2=CC3=C1OC(=O)C=C3",2.187,4,0,1]
["S1957","Sulfamethizole","f5","L3000-07","in 10mM DMSO","Bacterial","Microbiology","Sulfamethizole is a sulfathiazole antibacterial agent.",270.33,"144-82-1",{"v":54,"d":"54.00"},199.76,"<1","N/A","http://selleckchem.com/products/Sulfamethizole(Proklar).html","C9H10N4O2S2","free base","N/A","CC1=NN=C(N[S](=O)(=O)C2=CC=C(N)C=C2)S1",0.305,4,2,3]
["S1959","Tolfenamic Acid","g5","L3000-07","in 10mM DMSO","COX","Neuronal Signaling","Tolfenamic Acid(Clotam) is a COX-2 inhibitor with IC50 of 0.2 μM.",{"v":261.7,"d":"261.70"},"13710-19-5",{"v":52,"d":"52.00"},{"v":198.7,"d":"198.70"},"<1","N/A","http://selleckchem.com/products/tolfenamic-acid.html","C14H12ClNO2","free base","Clotam","CC1=C(Cl)C=CC=C1NC2=C(C=CC=C2)C(O)=O",{"v":4.16,"d":"4.160"},1,1,3]
["S1965","Primidone","h5","L3000-07","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.",218.25,"125-33-7",{"v":44,"d":"44.00"},{"v":201.6,"d":"201.60"},"<1","N/A","http://selleckchem.com/products/Primidone(Mysoline).html","C12H14N2O2","free base","NCI-C56360","CCC1(C(=O)NCNC1=O)C2=CC=CC=C2",0.931,2,2,2]
["S1969","Nefiracetam","a6","L3000-07","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.",{"v":246.3,"d":"246.30"},"77191-36-7",{"v":49,"d":"49.00"},198.94,{"v":5,"d":"5.00"},{"v":20.3,"d":"20.30"},"http://selleckchem.com/products/Nefiracetam(Translon).html","C14H18N2O2","free base","DZL 221","CC1=CC=CC(=C1NC(=O)CN2CCCC2=O)C",1.443,2,1,3]
["S1971","Nicorandil","b6","L3000-07","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).",211.17,"65141-46-0",{"v":42,"d":"42.00"},198.89,{"v":17,"d":"17.00"},{"v":80.5,"d":"80.50"},"http://selleckchem.com/products/Nicorandil(Ikorel).html","C8H9N3O4","free base","SG-75","[O-][N+](=O)OCCNC(=O)C1=CC=CN=C1",1.758,3,1,5]
["S1972","Tamoxifen (ICI 46474) Citrate","c6","L3000-07","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Endocrinology & Hormones","Tamoxifen Citrate (Istubal,ICI 46474 Citrate) is a selective estrogen receptor modulator (SERM). Tamoxifen Citrate is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis and autophagy.",563.64,"54965-24-1",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://selleckchem.com/products/Tamoxifen-Citrate(Nolvadex).html","C26H29NO.C6H8O7","Citrate","Istubal,ICI 46474 Citrate","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1973","Cyclocytidine HCl","d6","L3000-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.",261.66,"10212-25-6",{"v":10,"d":"10.00"},38.22,{"v":44,"d":"44.00"},168.16,"http://selleckchem.com/products/cyclocytidine-hcl.html","C9H12ClN3O4","Hydrochloride","NSC 145668 HCl","Cl.OCC1OC2C(OC3=NC(=N)C=CN23)C1O",-1.395,3,2,1]
["S1975","Aripiprazole","e6","L3000-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.",448.39,"129722-12-9",{"v":90,"d":"90.00"},200.72,"<1","N/A","http://selleckchem.com/products/aripiprazole-abilify.html","C23H27Cl2N3O2","free base","OPC-14597","ClC1=CC=CC(=C1Cl)N2CCN(CCCCOC3=CC=C4CCC(=O)NC4=C3)CC2",4.998,2,1,7]
["S1978","Methscopolamine","f6","L3000-07","in 10mM DMSO","AChR","Neuronal Signaling","Methscopolamine is a muscarinic acetylcholine receptor blocker.",398.29,"155-41-9",{"v":79,"d":"79.00"},198.35,{"v":67,"d":"67.00"},168.22,"http://selleckchem.com/products/Methscopolamine-bromide(Pamine).html","C18H24BrNO4","quaternary-N bromide salt","N/A","[Br-].C[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",-2.949,3,1,5]
["S1979","Amiodarone (NSC 85442) HCl","g6","L3000-07","in 10mM DMSO","Autophagy,Potassium Channel","Transmembrane Transporters","Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.",681.77,"19774-82-4",{"v":23,"d":"23.00"},33.74,"<1","N/A","http://selleckchem.com/products/amiodarone-hcl.html","C25H29I2NO3.HCl","Hydrochloride","Amiodar,Amiodarone hydrochloride,Nexterone","Cl.CCCCC1=C(C(=O)C2=CC(=C(OCCN(CC)CC)C(=C2)I)I)C3=C(O1)C=CC=C3",{"v":7.62,"d":"7.620"},3,0,11]
["S1990","Capsaicin(Vanilloid)","h6","L3000-07","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Capsaicin (Qutenza, Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.",305.41,"404-86-4",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://selleckchem.com/products/capsaicin.html","C18H27NO3","free base","Qutenza, Vanilloid","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C\\C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S1992","Fluticasone propionate","a7","L3000-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.",500.57,"80474-14-2",{"v":100,"d":"100.00"},199.77,"<1","N/A","http://selleckchem.com/products/fluticasone-propionate-Flonase-Veramyst.html","C25H31F3O5S","free base","CCI-187881","CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)SCF",4.086,4,1,6]
["S2003","Maraviroc (UK-427857)","b7","L3000-07","in 10mM DMSO","CCR,HIV","Microbiology","Maraviroc (Celsentri,UK-427857) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.",513.67,"376348-65-1",{"v":100,"d":"100.00"},194.68,"<1","N/A","http://selleckchem.com/products/Maraviroc.html","C29H41F2N5O","free base","Celsentri,UK-427857","CC(C)C1=NN=C(C)[N]1C2CC3CCC(C2)N3CCC(NC(=O)C4CCC(F)(F)CC4)C5=CC=CC=C5",3.921,3,1,8]
["S2006","Pyrimethamine","c7","L3000-07","in 10mM DMSO","DHFR","Metabolism","Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.",248.71,"58-14-0",{"v":10,"d":"10.00"},40.21,"<1","N/A","http://selleckchem.com/products/Pyrimethamine.html","C12H13ClN4","free base","RP 4753","CCC1=NC(=NC(=C1C2=CC=C(Cl)C=C2)N)N",{"v":2.75,"d":"2.750"},2,2,2]
["S2007","Sulindac","d7","L3000-07","in 10mM DMSO","COX","Neuronal Signaling","Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.",356.41,"38194-50-2",{"v":71,"d":"71.00"},199.21,"<1","N/A","http://selleckchem.com/products/Sulindac(Clinoril).html","C20H17FO3S","free base","MK-231","CC1=C(CC(O)=O)C2=C(C=CC(=C2)F)\\C1=C/C3=CC=C(C=C3)[S](C)=O",3.639,2,0,4]
["S2012","PCI-34051","e7","L3000-07","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.",296.32,"950762-95-5",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/pci-34051.html","C17H16N2O3","free base","N/A","COC1=CC=C(C[N]2C=CC3=C2C=C(C=C3)C(=O)NO)C=C1",2.911,2,1,4]
["S2013","PF-573228","f7","L3000-07","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis.",491.49,"869288-64-2",{"v":26,"d":"26.00"},{"v":52.9,"d":"52.90"},"<1","N/A","http://selleckchem.com/products/pf-573228.html","C22H20F3N5O3S","free base","N/A","C[S](=O)(=O)C1=CC(=CC=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(NC(=O)CC4)C=C3",3.967,5,3,7]
["S2014","BMS-265246","g7","L3000-07","in 10mM DMSO","CDK","Cell Cycle","BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.",345.34,"582315-72-8",{"v":20,"d":"20.00"},57.91,"<1","N/A","http://selleckchem.com/products/bms-265246.html","C18H17F2N3O2","free base","N/A","CCCCOC1=C2C=N[NH]C2=NC=C1C(=O)C3=C(F)C=C(C)C=C3F",4.135,4,1,6]
["S2015","Suplatast Tosylate","h7","L3000-07","in 10mM DMSO","Interleukins","Immunology & Inflammation","Suplatast Tosylate (IPD-1151T, Suplatast Tosilate) is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.",499.64,"94055-76-2",{"v":100,"d":"100.00"},200.14,{"v":100,"d":"100.00"},200.14,"http://selleckchem.com/products/suplatast-tosilate.html","C23H33NO7S2","Tosylate","IPD-1151T, Suplatast Tosilate","CCOCC(O)COC1=CC=C(NC(=O)CC[S+](C)C)C=C1.CC2=CC=C(C=C2)[S]([O-])(=O)=O",0.877,3,2,11]
["S2017","Benidipine HCl","a8","L3000-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Benidipine HCl (KW-3049,(±)- Benidipine) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.",542.02,"91599-74-5",{"v":8,"d":"8.00"},14.76,"<1","N/A","http://selleckchem.com/products/benidipine-hydrochloride.html","C28H31N3O6.HCl","Hydrochloride","KW-3049,(±)- Benidipine","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC3CCCN(C3)CC4=CC=CC=C4)C",{"v":4.36,"d":"4.360"},4,1,9]
["S2018","ENMD-2076 L-(+)-Tartaric acid","b8","L3000-07","in 10mM DMSO","Aurora Kinase,FLT3,VEGFR","Angiogenesis","ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.",525.56,"1291074-87-7",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/enmd-2076-l-tartaric-acid.html","C25H31N7O6","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)\\C=C\\C4=CC=CC=C4.OC(C(O)C(O)=O)C(O)=O",-0.683,5,4,8]
["S2020","Formoterol Hemifumarate","c8","L3000-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).",{"v":402.4,"d":"402.40"},"43229-80-7",{"v":80,"d":"80.00"},198.81,"<1","N/A","http://selleckchem.com/products/formoterol-hemifumarate.html","C19H24N2O4.1/2C4H4O4","Hemifumarate","Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate","COC1=CC=C(CC(C)NCC(O)C2=CC=C(O)C(=C2)NC=O)C=C1.COC3=CC=C(CC(C)NCC(O)C4=CC=C(O)C(=C4)NC=O)C=C3.OC(=O)\\C=C\\C(O)=O",-1.526,6,8,18]
["S2024","Ketotifen Fumarate","d8","L3000-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ketotifen Fumarate(HC 20511 fumarate) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.",{"v":425.5,"d":"425.50"},"34580-14-8",{"v":8,"d":"8.00"},{"v":18.8,"d":"18.80"},"<1","N/A","http://selleckchem.com/products/ketotifen-fumarate-zaditor.html","C19H19NOS.C4H4O4","Fumarate","HC 20511 fumarate","CN1CCC(CC1)=C2C3=C(CC(=O)C4=C2C=CS4)C=CC=C3.OC(=O)\\C=C\\C(O)=O",0.772,3,0,2]
["S2025","Urapidil HCl","e8","L3000-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.",423.94,"64887-14-5",{"v":24,"d":"24.00"},56.61,{"v":85,"d":"85.00"},{"v":200.5,"d":"200.50"},"http://selleckchem.com/products/urapidil-hydrochloride.html","C20H29N5O3.HCl","Hydrochloride","N/A","Cl.COC1=CC=CC=C1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2",1.808,3,1,7]
["S2026","Ginkgolide A","f8","L3000-07","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.",{"v":408.4,"d":"408.40"},"15291-75-5",{"v":81,"d":"81.00"},198.33,"<1","N/A","http://selleckchem.com/products/ginkgolide-a.html","C20H24O9","free base","BN52020","CC1C(=O)OC2CC34C5CC(C(C)(C)C)C36C(O)C(=O)OC6OC4(C(=O)O5)C12O",-0.022,7,1,1]
["S2028","Diclazuril","g8","L3000-07","in 10mM DMSO","Parasite","Microbiology","Diclazuril(R-64433) is an anti-coccidial drug.",407.64,"101831-37-2",{"v":16,"d":"16.00"},39.25,"<1","N/A","http://selleckchem.com/products/diclazuril.html","C17H9Cl3N4O2","free base","R-64433","ClC1=CC=C(C=C1)C(C#N)C2=C(Cl)C=C(C=C2Cl)N3N=CC(=O)NC3=O",4.191,3,1,3]
["S2029","Uridine","h8","L3000-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.",{"v":244.2,"d":"244.20"},"58-96-8",{"v":49,"d":"49.00"},200.66,{"v":49,"d":"49.00"},200.66,"http://selleckchem.com/products/uridine.html","C9H12N2O6","free base","NSC 20256,β-Uridine, Uridin","OCC1OC(C(O)C1O)N2C=CC(=O)NC2=O",-2.451,3,4,2]
["S2032","Rebamipide","a9","L3000-07","in 10mM DMSO","CCK receptor","GPCR & G Protein","Rebamipide (OPC-12759,Proamipide) is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.",370.79,"90098-04-7",{"v":74,"d":"74.00"},199.57,"<1","N/A","http://selleckchem.com/products/rebamipide.html","C19H15ClN2O4","free base","OPC-12759,Proamipide","OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C3=CC=C(Cl)C=C3",2.606,3,2,5]
["S2037","Candesartan Cilexetil","b9","L3000-07","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.",610.66,"145040-37-5",{"v":122,"d":"122.00"},199.78,"<1","N/A","http://selleckchem.com/products/Candesartan-cilexetil-Atacand.html","C33H34N6O6","free base","TCV-116","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=N[NH]5)C(=CC=C2)C(=O)OC(C)OC(=O)OC6CCCCC6",6.913,10,1,13]
["S2038","Phentolamine Mesylate","c9","L3000-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Phentolamine Mesylate(Phentolamine methanesulfonate) is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.",377.46,"65-28-1",{"v":76,"d":"76.00"},201.35,{"v":76,"d":"76.00"},201.35,"http://selleckchem.com/products/phentolamine-mesilate.html","C17H19N3O.CH4O3S","Mesylate","Phentolamine methanesulfonate","CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.C[S](O)(=O)=O",2.555,1,2,4]
["S2040","Nimesulide","d9","L3000-07","in 10mM DMSO","COX","Neuronal Signaling","Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.",308.31,"51803-78-2",{"v":62,"d":"62.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://selleckchem.com/products/Nimesulide.html","C13H12N2O5S","free base","N/A","C[S](=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O",2.195,3,1,5]
["S2042","Cyproterone Acetate","e9","L3000-07","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.",416.94,"427-51-0",{"v":83,"d":"83.00"},199.07,"<1","N/A","http://selleckchem.com/products/cyproterone-acetate.html","C24H29ClO4","free base","N/A","CC(=O)OC1(CCC2C3C=C(Cl)C4=CC(=O)C5CC5C4(C)C3CCC12C)C(C)=O",3.314,4,0,3]
["S2045","Doxifluridine","f9","L3000-07","in 10mM DMSO","Phosphorylase","Metabolism","Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).",246.19,"3094-09-5",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/doxifluridine.html","C9H11FN2O5","free base","5'-DFUR, AMC 0101","CC1OC(C(O)C1O)N2C=C(F)C(=O)NC2=O",-1.653,3,3,1]
["S2046","Pioglitazone HCl","g9","L3000-07","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17),PPAR","Metabolism","Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.",{"v":392.9,"d":"392.90"},"112529-15-4",{"v":79,"d":"79.00"},201.07,"<1","N/A","http://selleckchem.com/products/pioglitazone-hydrochloride-actos.html","C19H20N2O3S.HCl","Hydrochloride","AD-4833, U-72107E","Cl.CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",4.289,4,1,7]
["S2051","Captopril","h9","L3000-07","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.",217.29,"62571-86-2",{"v":43,"d":"43.00"},197.89,{"v":2,"d":"2.00"},{"v":9.2,"d":"9.20"},"http://selleckchem.com/products/captopril-capoten.html","C9H15NO3S","free base","SQ 14225,Capoten","CC(CS)C(=O)N1CCCC1C(O)=O",0.667,2,0,3]
["S2053","Cytidine","a10","L3000-07","in 10mM DMSO","Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.",243.22,"65-46-3",{"v":49,"d":"49.00"},201.46,{"v":49,"d":"49.00"},201.46,"http://selleckchem.com/products/cytidine.html","C9H13N3O5","free base","N/A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S2055","Gimeracil","b10","L3000-07","in 10mM DMSO","Dehydrogenase","Metabolism","Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.",145.54,"103766-25-2",{"v":29,"d":"29.00"},199.26,"<1","N/A","http://selleckchem.com/products/gimeracil.html","C5H4ClNO2","free base","N/A","OC1=CC(=O)NC=C1Cl",-0.493,1,2,0]
["S2057","Cyclophosphamide (NSC-26271) Monohydrate","c10","L3000-07","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.",{"v":279.1,"d":"279.10"},"6055-19-2",{"v":55,"d":"55.00"},197.06,{"v":7,"d":"7.00"},25.08,"http://selleckchem.com/products/cyclophosphamide-monohydrate.html","C7H15Cl2N2O2P.H2O","Monohydrate","Cytoxan Monohydrate","O.ClCCN(CCCl)[P]1(=O)NCCCO1",-0.063,2,1,5]
["S2058","Tolnaftate","d10","L3000-07","in 10mM DMSO","Fungal","Microbiology","Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent.",307.41,"2398-96-1",{"v":62,"d":"62.00"},201.69,"<1","N/A","http://selleckchem.com/products/tolnaftate.html","C19H17NOS","free base","N/A","CN(C(=S)OC1=CC=C2C=CC=CC2=C1)C3=CC(=CC=C3)C",6.289,1,0,4]
["S2059","Terazosin HCl Dihydrate","e10","L3000-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).",459.92,"70024-40-7",{"v":26,"d":"26.00"},56.53,"<1","N/A","http://selleckchem.com/products/terazosin-hydrochloride-hytrin.html","C19H25N5O4.HCl.2H2O","HCl & Dihydrate","N/A","O.O.Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N",1.348,6,1,4]
["S2061","Lovastatin (MK-803)","f10","L3000-07","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Lovastatin (MK-803, Mevinolin,Mevacor) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.",404.54,"75330-75-5",{"v":8,"d":"8.00"},19.78,"<1","N/A","http://selleckchem.com/products/lovastatin-mevacor.html","C24H36O5","free base","Mevinolin,Mevacor","CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.218,4,1,7]
["S2064","Balofloxacin","g10","L3000-07","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Balofloxacin (Q-35,Q-roxin) is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.",389.42,"127294-70-6",{"v":5,"d":"5.00"},12.84,"<1","N/A","http://selleckchem.com/products/balofloxacin.html","C20H24FN3O4","free base","Q-35,Q-roxin","CNC1CCCN(C1)C2=C(OC)C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O",-0.615,3,1,5]
["S2065","Lafutidine","h10","L3000-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lafutidine (FRG-8813), a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.",431.55,"118288-08-7",{"v":86,"d":"86.00"},199.28,"<1","N/A","http://selleckchem.com/products/lafutidine.html","C22H29N3O4S","free base","FRG-8813","O=C(C[S](=O)CC1=CC=CO1)NC\\C=C/COC2=CC(=CC=N2)CN3CCCCC3",1.987,5,1,11]
["S2067","Ozagrel HCl","a11","L3000-07","in 10mM DMSO","P450 (e.g. CYP17),Prostaglandin Receptor","Metabolism","Ozagrel HCl (OKY-046) is a selective <n>thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.",264.71,"78712-43-3",{"v":52,"d":"52.00"},196.44,{"v":52,"d":"52.00"},196.44,"http://selleckchem.com/products/ozagrel-hydrochloride.html","C13H12N2O2.HCl","HCl","OKY-046 HCl","Cl.OC(=O)/C=C/C1=CC=C(C[N]2C=CN=C2)C=C1",1.986,2,0,4]
["S2069","Argatroban (MCI-9038)","b11","L3000-07","in 10mM DMSO","Thrombin","Proteases","Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.",508.63,"74863-84-6",{"v":9,"d":"9.00"},17.69,"<1","N/A","http://selleckchem.com/products/argatroban.html","C23H36N6O5S","free base","MCI-9038","CC1CCN(C(C1)C(O)=O)C(=O)C(CCCNC(N)=N)N[S](=O)(=O)C2=CC=CC3=C2NCC(C)C3",1.266,4,4,10]
["S2072","Seratrodast(AA-2414)","c11","L3000-07","in 10mM DMSO","Prostaglandin Receptor","Metabolism","Seratrodast (AA-2414, ABT-001) is a potent and selective thromboxane A2 receptor (TP) antagonist which is used primarily in the treatment of asthma and used as anti-inflammatory agent.",354.44,"112665-43-7",{"v":71,"d":"71.00"},200.32,"<1","N/A","http://www.selleck.cn/products/seratrodast.html","C22H26O4","Free Base","ABT-001","CC1=C(C)C(=O)C(=C(C)C1=O)C(CCCCCC(O)=O)C2=CC=CC=C2",5.216,3,0,8]
["S2077","Atorvastatin Calcium","d11","L3000-07","in 10mM DMSO","Apoptosis related,Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.",1155.34,"134523-03-8",{"v":100,"d":"100.00"},86.55,"<1","N/A","http://selleckchem.com/products/atorvastatin-calcium-lipitor.html","2(C33H34FN2O5).Ca","Calcium","N/A","[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8",8.163,2,6,24]
["S2078","Famotidine","e11","L3000-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.",337.45,"76824-35-6",{"v":67,"d":"67.00"},198.55,"<1","N/A","http://selleckchem.com/products/famotidine-pepcid.html","C8H15N7O2S3","free base","MK208","NC(=N)NC1=NC(=CS1)CSCCC(=N)N[S](N)(=O)=O",-1.328,3,4,9]
["S2080","Clevidipine Butyrate","f11","L3000-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Clevidipine Butyrate(Cleviprex) is a dihydropyridine calcium channel blocker,  uses as an agent for the reduction of blood pressure.",456.32,"167221-71-8",{"v":91,"d":"91.00"},199.42,"<1","N/A","http://selleckchem.com/products/cleviprex-clevidipine.html","C21H23Cl2NO6","free base","Cleviprex","CCCC(=O)OCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",4.145,6,1,10]
["S2082","Adiphenine HCl","g11","L3000-07","in 10mM DMSO","AChR","Neuronal Signaling","Adiphenine HCl(NSC 129224) is a nicotinic receptor inhibitor, used as an antispasmodic drug.",347.88,"50-42-0",{"v":30,"d":"30.00"},86.24,{"v":70,"d":"70.00"},201.22,"http://selleckchem.com/products/adiphenine-hcl.html","C20H25NO2.HCl","HCl","NSC 129224","Cl.CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2",4.433,2,0,9]
["S2086","Ivabradine HCl","h11","L3000-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.",505.05,"148849-67-6",{"v":101,"d":"101.00"},199.98,{"v":82,"d":"82.00"},162.36,"http://selleckchem.com/products/ivabradine-hcl-procoralan.html","C27H36N2O5.HCl","HCl","S 16257-2,S-18982 D6 hydrochloride","Cl.COC1=CC2=C(CC(=O)N(CCCN(C)CC3CC4=CC(=C(OC)C=C34)OC)CC2)C=C1OC",3.753,5,0,10]
["S2087","Rivastigmine Tartrate","a2","L3000-08","in 10mM DMSO","AChR","Neuronal Signaling","Rivastigmine Tartrate (ENA 713) is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.",400.42,"129101-54-8",{"v":42,"d":"42.00"},104.89,{"v":80,"d":"80.00"},199.79,"http://selleckchem.com/products/rivastigmine-tartrate-exelon.html","C14H22N2O2.C4H6O6","Tartrate","ENA 713","CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.OC(C(O)C(O)=O)C(O)=O",-2.099,4,2,8]
["S2090","Dexmedetomidine HCl","b2","L3000-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.",236.74,"145108-58-3",{"v":48,"d":"48.00"},202.75,"<1","N/A","http://selleckchem.com/products/dexmedetomidine-hcl-precedex.html","C13H16N2.HCl","HCl","(+)-Medetomidine Hydrochloride","Cl.CC(C1=CN=C[NH]1)C2=CC=CC(=C2C)C",3.378,1,1,2]
["S2096","Almotriptan Malate","c2","L3000-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Almotriptan Malate (LAS 31416) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.",469.55,"181183-52-8",{"v":94,"d":"94.00"},200.19,"<1","N/A","http://selleckchem.com/products/almotriptan-malate-axert.html","C17H25N3O2S.C4H6O5","Malate","LAS 31416","CN(C)CCC1=C[NH]C2=CC=C(C[S](=O)(=O)N3CCCC3)C=C12.OC(CC(O)=O)C(O)=O",-1.943,4,2,9]
["S2098","Bexarotene (LGD1069)","d2","L3000-08","in 10mM DMSO","Retinoid Receptor","Metabolism","Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.",{"v":348,"d":"348.00"},"153559-49-0",{"v":8,"d":"8.00"},22.99,"<1","N/A","http://selleckchem.com/products/bexarotene.html","C24H28O2","free base","Targretin","CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(O)=O)C(C)(C)CCC2(C)C",6.405,1,0,3]
["S2099","Temocapril HCl","e2","L3000-08","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.",513.07,"110221-44-8",{"v":103,"d":"103.00"},200.75,"<1","N/A","http://selleckchem.com/products/temocapril-hcl.html","C23H28N2O5S2.HCl","Hydrochloride","CS-622 HCl","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(CC(O)=O)C2=O)C3=CC=CS3",0.787,4,1,11]
["S2101","Gabexate Mesylate","f2","L3000-08","in 10mM DMSO","Serine Protease","Proteases","Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.",417.48,"56974-61-9",{"v":83,"d":"83.00"},198.81,{"v":12,"d":"12.00"},28.74,"http://selleckchem.com/products/gabexate-mesylate.html","C16H23N3O4.CH4O3S","Mesylate","FOY","CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1.C[S](O)(=O)=O",1.774,4,2,12]
["S2102","Rasagiline Mesylate","g2","L3000-08","in 10mM DMSO","MAO","Metabolism","Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.",267.34,"161735-79-1",{"v":53,"d":"53.00"},198.25,{"v":53,"d":"53.00"},198.25,"http://selleckchem.com/products/rasagiline-mesylate.html","C12H13N.CH4O3S","Mesylate","TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate","C[S](O)(=O)=O.C#CCNC1CCC2=CC=CC=C12",2.705,0,1,2]
["S2103","Naltrexone HCl","h2","L3000-08","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.",377.86,"16676-29-2",{"v":14,"d":"14.00"},37.05,{"v":14,"d":"14.00"},37.05,"http://selleckchem.com/products/naltrexone-hcl.html","C20H23NO4.HCl","Hydrochloride","PTI-901","Cl.OC1=CC=C2CC3N(CCC45C(OC1=C24)C(=O)CCC35O)CC6CC6",2.039,2,1,2]
["S2105","Pantoprazole","a3","L3000-08","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",383.37,"102625-70-7",{"v":76,"d":"76.00"},198.24,"<1","N/A","http://selleckchem.com/products/pantoprazole-protonix.html","C16H15F2N3O4S","free base","SKFSKF96022, BY-1023","COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=CC=C(OC(F)F)C=C3[NH]2",2.737,6,1,7]
["S2108","Flunixin Meglumin","b3","L3000-08","in 10mM DMSO","COX","Neuronal Signaling","Flunixin Meglumin(Banamine) is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.",491.46,"42461-84-7",{"v":98,"d":"98.00"},199.41,{"v":98,"d":"98.00"},199.41,"http://selleckchem.com/products/flunixin-meglumin.html","C14H11F3N2O2.C7H17NO5","Meglumin","Banamine","CNCC(O)C(O)C(O)C(O)CO.CC1=C(C=CC=C1NC2=NC=CC=C2C(O)=O)C(F)(F)F",-1.676,2,7,10]
["S2109","Imidapril HCl","c3","L3000-08","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.",441.91,"89396-94-1",{"v":88,"d":"88.00"},199.14,{"v":54,"d":"54.00"},{"v":122.2,"d":"122.20"},"http://selleckchem.com/products/imidapril-tanatril.html","C20H27N3O6.HCl","Hydrochloride","TA-6366","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C)C2=O)C(O)=O",-1.197,5,1,10]
["S2111","Lapatinib (GW-572016)","d3","L3000-08","in 10mM DMSO","Autophagy,EGFR,Ferroptosis,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.",581.06,"231277-92-2",{"v":100,"d":"100.00"},{"v":172.1,"d":"172.10"},"<1","N/A","http://selleckchem.com/products/lapatinib.html","C29H26ClFN4O4S","free base","GSK572016, GW2016","C[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(=C5)F)C(=C4)Cl)C3=C2",6.041,6,2,11]
["S2113","Cisatracurium Besylate","e3","L3000-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Cisatracurium Besylate(51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.",1243.48,"96946-42-8",{"v":249,"d":"249.00"},200.24,{"v":47,"d":"47.00"},{"v":37.8,"d":"37.80"},"http://selleckchem.com/products/cisatracurium-besylate-nimbex.html","C53H72N2O12.2C6H5O3S","Besylate","51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S2114","Dronedarone HCl","f3","L3000-08","in 10mM DMSO","Calcium Channel,Potassium Channel,Sodium Channel","Transmembrane Transporters","Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).",593.22,"141625-93-6",{"v":80,"d":"80.00"},134.86,"<1","N/A","http://selleckchem.com/products/dronedarone-hcl-multaq.html","C31H44N2O5S.HCl","HCl","SR33589","Cl.CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=CC=C(N[S](C)(=O)=O)C=C23",7.397,5,1,18]
["S2118","Ibutilide Fumarate","g3","L3000-08","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ibutilide Fumarate (U-70226E,Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.",885.23,"122647-32-9",{"v":89,"d":"89.00"},100.54,{"v":89,"d":"89.00"},100.54,"http://selleckchem.com/products/ibutilide-fumarate.html","(C20H36N2O3S)2.C4H4O4","Fumarate","U-70226E,Corvert Fumarate","CCCCCCCN(CC)CCCC(O)C1=CC=C(N[S](C)(=O)=O)C=C1.CCCCCCCN(CC)CCCC(O)C2=CC=C(N[S](C)(=O)=O)C=C2.OC(=O)\\C=C\\C(O)=O",1.954,6,4,30]
["S2119","Probucol","h3","L3000-08","in 10mM DMSO","LDL","Metabolism","Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.",516.84,"23288-49-5",{"v":103,"d":"103.00"},199.29,"<1","N/A","http://selleckchem.com/products/probucol.html","C31H48O2S2","free base","DH-581","CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(O)C(=C2)C(C)(C)C)C(C)(C)C",9.779,0,2,8]
["S2125","Mestranol","a4","L3000-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.",310.43,"72-33-3",{"v":15,"d":"15.00"},48.32,"<1","N/A","http://selleckchem.com/products/Mestranol.html","C21H26O2","free base","N/A","COC1=CC2=C(C=C1)C3CCC4(C)C(CCC4(O)C#C)C3CC2",5.112,1,0,1]
["S2126","Naftopidil","b4","L3000-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Naftopidil (KT-611) is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.",392.49,"57149-07-2",{"v":79,"d":"79.00"},201.28,"<1","N/A","http://selleckchem.com/products/Naftopidil(Flivas).html","C24H28N2O3","Free Base","KT-611","COC1=CC=CC=C1N2CCN(CC2)CC(O)COC3=C4C=CC=CC4=CC=C3",3.962,2,1,7]
["S2127","S-(+)-Rolipram","c4","L3000-08","in 10mM DMSO","PDE","Metabolism","S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.",275.34,"85416-73-5",{"v":55,"d":"55.00"},199.75,"<1","N/A","http://selleckchem.com/products/sRolipram.html","C16H21NO3","free base","N/A","COC1=C(OC2CCCC2)C=C(C=C1)C3CNC(=O)C3",2.349,3,1,4]
["S2128","Bazedoxifene (WAY-140424) HCl","d4","L3000-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bazedoxifene HCl (WAY-140424, TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of  23 nM and 89 nM, respectively.",507.06,"198480-56-7",{"v":101,"d":"101.00"},199.19,"<1","N/A","http://selleckchem.com/products/bazedoxifene-hcl.html","C30H34N2O3.HCl","Hydrochloride","TSE-424","Cl.CC1=C([N](CC2=CC=C(OCCN3CCCCCC3)C=C2)C4=CC=C(O)C=C14)C5=CC=C(O)C=C5",7.602,1,2,7]
["S2130","Atropine sulfate monohydrate","e4","L3000-08","in 10mM DMSO","AChR,ADC Cytotoxin","Neuronal Signaling","Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.",694.83,"5908-99-6",{"v":139,"d":"139.00"},200.05,{"v":139,"d":"139.00"},200.05,"http://selleckchem.com/products/Atropine-sulfate-monohydrate.html","2(C17H23NO3).H2O.H2SO4","Sulfate monohydrate","N/A","O.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.628,4,2,10]
["S2131","Roflumilast (B9302-107)","f4","L3000-08","in 10mM DMSO","PDE","Metabolism","Roflumilast (APTA 2217, B9302-107, BY 217, BYK 20869) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.",403.21,"162401-32-3",{"v":81,"d":"81.00"},200.89,"<1","N/A","http://selleckchem.com/products/Roflumilast(Daxas).html","C17H14Cl2F2N2O3","free base","APTA 2217, B9302-107, BY 217, BYK 20869","FC(F)OC1=CC=C(C=C1OCC2CC2)C(=O)NC3=C(Cl)C=NC=C3Cl",4.402,4,1,7]
["S2134","AZD8330","g4","L3000-08","in 10mM DMSO","MEK","MAPK","AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.",461.23,"869357-68-6",{"v":92,"d":"92.00"},199.47,"<1","N/A","http://selleckchem.com/products/AZD8330(ARRY-424704).html","C16H17FIN3O4","free base","ARRY704","CN1C(=O)C(=CC(=C1NC2=C(F)C=C(I)C=C2)C(=O)NOCCO)C",1.653,3,3,6]
["S2149","GSK1292263","h4","L3000-08","in 10mM DMSO","GPR","Endocrinology & Hormones","GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. Phase 2.",456.56,"1032823-75-8",{"v":34,"d":"34.00"},74.47,"<1","N/A","http://selleckchem.com/products/GSK1292263.html","C23H28N4O4S","free base","N/A","CC(C)C1=NOC(=N1)N2CCC(CC2)COC3=CN=C(C=C3)C4=CC=C(C=C4)[S](C)(=O)=O",3.893,7,0,7]
["S2151","Sonidegib (NVP-LDE225)","a5","L3000-08","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.",{"v":485.5,"d":"485.50"},"956697-53-3",{"v":97,"d":"97.00"},199.79,"<1","N/A","http://selleckchem.com/products/LDE225(NVP-LDE225).html","C26H26F3N3O3","free base","Erismodegib","CC1CN(CC(C)O1)C2=CC=C(NC(=O)C3=C(C)C(=CC=C3)C4=CC=C(OC(F)(F)F)C=C4)C=N2",6.732,4,1,6]
["S2153","CGS 21680 HCl","b5","L3000-08","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.",535.98,"124431-80-7",{"v":100,"d":"100.00"},186.57,"<1","N/A","http://selleckchem.com/products/CGS-21680-hydrochloride.html","C23H29N7O6.HCl","Hydrochloride","N/A","Cl.CCNC(=O)C1OC(C(O)C1O)[N]2C=NC3=C2N=C(NCCC4=CC=C(CCC(O)=O)C=C4)N=C3N",0.911,6,5,10]
["S2154","Dabigatran (BIBR-1048) etexilate","c5","L3000-08","in 10mM DMSO","Thrombin","Proteases","Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.",627.73,"211915-06-9",{"v":126,"d":"126.00"},200.72,"<1","N/A","http://selleckchem.com/products/BIBR-1048(Dabigatran-etexilate).html","C34H41N7O5","free base","BIBR-1048","CCCCCCOC(=O)N=C(N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)[N]2C)C=C1",5.751,8,2,17]
["S2155","LY2608204","d5","L3000-08","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.",559.81,"1234703-40-2",{"v":112,"d":"112.00"},200.07,"<1","N/A","http://selleckchem.com/products/ly2608204.html","C28H37N3O3S3","free base","N/A","O=C(NC1=NC=C(SCCN2CCCC2)S1)C3(CC3C4CCCCC4)C5=CC=C(C=C5)[S](=O)(=O)C6CC6",5.393,4,1,10]
["S2156","LY2886721","e5","L3000-08","in 10mM DMSO","BACE","Neuronal Signaling","LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.",390.41,"1262036-50-9",{"v":9,"d":"9.00"},23.05,"<1","N/A","http://selleckchem.com/products/LY-2886721.html","C18H16F2N4O2S","free base","N/A","NC1=NC2(COCC2CS1)C3=CC(=CC=C3F)NC(=O)C4=NC=C(F)C=C4",2.134,4,2,3]
["S2158","KW-2449","f5","L3000-08","in 10mM DMSO","Aurora Kinase,Bcr-Abl,FLT3","Angiogenesis","KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.",{"v":332.4,"d":"332.40"},"1000669-72-6",{"v":67,"d":"67.00"},201.56,"<1","N/A","http://selleckchem.com/products/KW-2449.html","C20H20N4O","free base","N/A","O=C(N1CCNCC1)C2=CC=C(C=C2)/C=C/C3=N[NH]C4=C3C=CC=C4",2.723,2,2,3]
["S2160","Almorexant HCl","g5","L3000-08","in 10mM DMSO","OX Receptor","GPCR & G Protein","Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.",549.02,"913358-93-7",{"v":72,"d":"72.00"},131.14,"<1","N/A","http://selleckchem.com/products/almorexant-hcl.html","C29H32ClF3N2O3","Hydrochloride","ACT-078573 HCl","Cl.CNC(=O)C(N1CCC2=C(C=C(OC)C(=C2)OC)C1CCC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C4",6.438,3,1,9]
["S2161","RAF265 (CHIR-265)","h5","L3000-08","in 10mM DMSO","Apoptosis related,Raf,VEGFR","MAPK","RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.",518.41,"927880-90-8",{"v":100,"d":"100.00"},{"v":192.9,"d":"192.90"},"<1","N/A","http://selleckchem.com/products/RAF265(CHIR-265).html","C24H16F6N6O","free base","N/A","C[N]1C(=NC2=C1C=CC(=C2)OC3=CC=NC(=C3)C4=NC=C([NH]4)C(F)(F)F)NC5=CC=C(C=C5)C(F)(F)F",6.469,4,2,7]
["S2162","AZD1480","a6","L3000-08","in 10mM DMSO","JAK","JAK/STAT","AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.",348.77,"935666-88-9",{"v":70,"d":"70.00"},200.71,"<1","N/A","http://www.selleck.cn/products/AZD1480.html","C14H14ClFN8","free base","N/A","CC(NC1=NC=C(Cl)C(=N1)NC2=N[NH]C(=C2)C)C3=NC=C(F)C=N3",2.645,5,3,5]
["S2163","PF-4708671","b6","L3000-08","in 10mM DMSO","Autophagy,S6 Kinase","PI3K/Akt/mTOR","PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.",390.41,"1255517-76-0",{"v":30,"d":"30.00"},76.84,"<1","N/A","http://selleckchem.com/products/pf-4708671.html","C19H21F3N6","free base","N/A","CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C([NH]3)C=CC(=C4)C(F)(F)F",3.886,3,1,5]
["S2167","Bazedoxifene (TSE-424) acetate","c6","L3000-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bazedoxifene Acetate (WAY-140424,TSE-424 acetate) is a third generation selective estrogen receptor modulator (SERM).",530.65,"198481-33-3",{"v":100,"d":"100.00"},188.45,"<1","N/A","http://selleckchem.com/products/Bazedoxifene-acetate.html","C30H34N2O3.C2H4O2","Acetate","WAY-140424,TSE-424 acetate","CC(O)=O.CC1=C([N](CC2=CC=C(OCCN3CCCCCC3)C=C2)C4=CC=C(O)C=C14)C5=CC=C(O)C=C5",3.981,2,2,7]
["S2169","Rosuvastatin (ZD4522) calcium","d6","L3000-08","in 10mM DMSO","COVID-19,HMG-CoA Reductase","Metabolism","Rosuvastatin Calcium (ZD4522 calcium) is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.",500.57,"147098-20-2",{"v":100,"d":"100.00"},199.77,"<1","N/A","http://selleckchem.com/products/Rosuvastatin-calcium(Crestor).html","C22H28FN3O6S.1/2Ca","Calcium salt","ZD4522 calcium","[Ca++].CC(C)C1=C(\\C=C\\C(O)CC(O)CC([O-])=O)C(=NC(=N1)N(C)[S](C)(=O)=O)C2=CC=C(F)C=C2.CC(C)C3=C(\\C=C\\C(O)CC(O)CC([O-])=O)C(=NC(=N3)N(C)[S](C)(=O)=O)C4=CC=C(F)C=C4",1.906,8,4,20]
["S2170","Givinostat (ITF2357)","e6","L3000-08","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.",475.97,"732302-99-7",{"v":95,"d":"95.00"},199.59,"<1","N/A","http://selleckchem.com/products/ITF2357(Givinostat).html","C24H27N3O4.HCl.H2O","Chloride","N/A","O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC3=CC=C(C=C3)C(=O)NO)C=C2",4.046,3,2,9]
["S2173","Telotristat Etiprate (LX 1606 Hippurate)","f6","L3000-08","in 10mM DMSO","Hydroxylase","Metabolism","Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.",754.15,"1137608-69-5",{"v":100,"d":"100.00"},{"v":132.6,"d":"132.60"},"<1","N/A","http://selleckchem.com/products/telotristat-etiprate-lx-1606-hippurate.html","C27H26ClF3N6O3.C9H9NO3","Hippuric acid","N/A","CCOC(=O)C(N)CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=CC=C(Cl)C=C3[N]4C=CC(=N4)C)C(F)(F)F.OC(=O)CNC(=O)C5=CC=CC=C5",3.747,8,3,14]
["S2177","Dichlorphenamide","g6","L3000-08","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.",305.16,"120-97-8",{"v":61,"d":"61.00"},199.89,"N/A","N/A","http://www.selleckchem.com/products/Dichlorphenamide(Diclofenamide).html","C6H6Cl2N2O4S2","Free Base","Diclofenamide","N[S](=O)(=O)C1=CC(=C(Cl)C(=C1)[S](N)(=O)=O)Cl","N/A","N/A","N/A","N/A"]
["S2178","AG-14361","h6","L3000-08","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.",320.39,"328543-09-5",{"v":12,"d":"12.00"},37.45,"<1","N/A","http://selleckchem.com/products/AG14361.html","C19H20N4O","free base","N/A","CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3[N]2CCNC4=O",2.576,2,1,3]
["S2179","Gandotinib (LY2784544)","a7","L3000-08","in 10mM DMSO","JAK","JAK/STAT","Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.",469.94,"1229236-86-5",{"v":94,"d":"94.00"},200.03,"<1","N/A","http://selleckchem.com/products/LY2784544.html","C23H25ClFN7O","free base","N/A","CC1=N[NH]C(=C1)NC2=N[N]3C(=C(C)N=C3C(=C2)CN4CCOCC4)CC5=CC=C(Cl)C=C5F",3.938,4,2,6]
["S2180","Ixazomib (MLN2238)","b7","L3000-08","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.",361.03,"1072833-77-2",{"v":72,"d":"72.00"},199.43,"<1","N/A","http://selleckchem.com/products/MLN-2238.html","C14H19BCl2N2O4","Free Base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B(O)O",3.344,2,2,7]
["S2181","Ixazomib Citrate (MLN9708) Analogue","c7","L3000-08","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.",517.12,"1201902-80-8",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://selleckchem.com/products/MLN9708.html","C20H23BCl2N2O9","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)CC(CC(O)=O)(O2)C(O)=O",3.497,7,2,10]
["S2182","SB743921 HCl","d7","L3000-08","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.",553.52,"940929-33-9",{"v":111,"d":"111.00"},200.53,{"v":22,"d":"22.00"},39.75,"http://selleckchem.com/products/SB-743921.html","C31H33N2O3.HCl","Hydrochloride","N/A","Cl.CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=C(CC3=CC=CC=C3)C(=O)C4=C(O2)C=C(Cl)C=C4",6.536,3,1,9]
["S2183","Infigratinib (BGJ398)","e7","L3000-08","in 10mM DMSO","FGFR","Angiogenesis","Infigratinib (BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.",560.48,"872511-34-7",{"v":27,"d":"27.00"},48.17,"<1","N/A","http://www.selleck.cn/products/bgj398-nvp-bgj398.html","C26H31Cl2N7O3","Free Base","NVP-BGJ398","CCN1CCN(CC1)C2=CC=C(NC3=NC=NC(=C3)N(C)C(=O)NC4=C(Cl)C(=CC(=C4Cl)OC)OC)C=C2",5.342,5,2,8]
["S2185","Allitinib tosylate","f7","L3000-08","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Allitinib tosylate (AST-1306 TsOH, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.",621.08,"1050500-29-2",{"v":124,"d":"124.00"},199.65,"<1","N/A","https://www.selleckchem.com/products/allitinib-tosylate.html","C24H18ClFN4O2,C7H8O3S","Mesylate","AST-1306 TsOH, AST-6","CC1=CC=C(C=C1)[S](O)(=O)=O.FC2=CC(=CC=C2)COC3=CC=C(NC4=C5C=C(NC(=O)C=C)C=CC5=NC=N4)C=C3Cl",7.381,4,2,8]
["S2186","SB505124","g7","L3000-08","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.",{"v":335.4,"d":"335.40"},"694433-59-5",{"v":67,"d":"67.00"},199.76,"<1","N/A","http://selleckchem.com/products/sb-505124.html","C20H21N3O2","free base","N/A","CC1=CC=CC(=N1)C2=C(N=C([NH]2)C(C)(C)C)C3=CC4=C(OCO4)C=C3",4.609,4,1,3]
["S2187","Avasimibe (CI-1011)","h7","L3000-08","in 10mM DMSO","Acyltransferase,P450 (e.g. CYP17)","Metabolism","Avasimibe (CI-1011, PD-148515) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.",501.72,"166518-60-1",{"v":100,"d":"100.00"},199.31,"<1","N/A","http://selleckchem.com/products/Avasimibe(CI-1011).html","C29H43NO4S","free base","PD-148515","CC(C)C1=CC(=C(CC(=O)N[S](=O)(=O)OC2=C(C=CC=C2C(C)C)C(C)C)C(=C1)C(C)C)C(C)C",8.227,2,1,10]
["S2192","Sapitinib (AZD8931)","a8","L3000-08","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.",473.93,"848942-61-0",{"v":40,"d":"40.00"},{"v":84.4,"d":"84.40"},"<1","N/A","http://selleckchem.com/products/AZD8931.html","C23H25ClFN5O3","free base","N/A","CNC(=O)CN1CCC(CC1)OC2=C(OC)C=C3N=CN=C(NC4=C(F)C(=CC=C4)Cl)C3=C2",3.485,5,2,7]
["S2193","GSK461364","b8","L3000-08","in 10mM DMSO","PLK","Cell Cycle","GSK461364 (GSK461364A) inhibits purified Plk1 with Ki of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3.",{"v":543.6,"d":"543.60"},"929095-18-1",{"v":10,"d":"10.00"},{"v":18.4,"d":"18.40"},"<1","N/A","http://selleckchem.com/products/GSK461364.html","C27H28F3N5O2S","free base","GSK461364A","CC(OC1=C(SC(=C1)[N]2C=NC3=C2C=C(CN4CCN(C)CC4)C=C3)C(N)=O)C5=CC=CC=C5C(F)(F)F",5.125,3,1,8]
["S2194","R406","c8","L3000-08","in 10mM DMSO","Apoptosis related,FLT3,Syk","Angiogenesis","R406 is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 induces apoptosis. Phase 1.",628.63,"841290-81-1",{"v":100,"d":"100.00"},159.08,"<1","N/A","http://selleckchem.com/products/R406.html","C22H23FN6O5.C6H6O3S","Besylate","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC(=C(F)C=N2)NC3=NC4=C(OC(C)(C)C(=O)N4)C=C3)OC.O[S](=O)(=O)C5=CC=CC=C5",5.044,8,3,8]
["S2195","Lexibulin (CYT997)","d8","L3000-08","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.",434.53,"917111-44-5",{"v":86,"d":"86.00"},197.91,"<1","N/A","http://selleckchem.com/products/CYT997.html","C24H30N6O2","free base","SRI-32007","CCCC(NC1=C(C)C=NC(=N1)C2=CC(=C(NC(=O)NCC)C=C2)OC)C3=CC=CN=C3",3.744,5,3,9]
["S2197","A-966492","e8","L3000-08","in 10mM DMSO","PARP","DNA Damage/DNA Repair","A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.",324.35,"934162-61-5",{"v":64,"d":"64.00"},197.32,"<1","N/A","http://selleckchem.com/products/A-966492.html","C18H17FN4O","free base","N/A","NC(=O)C1=C2[NH]C(=NC2=CC=C1)C3=CC=C(C=C3F)C4CCCN4",2.505,2,3,3]
["S2198","SGI-1776 free base","f8","L3000-08","in 10mM DMSO","Apoptosis related,Autophagy,FLT3,Haspin Kinase,Pim","JAK/STAT","SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.",405.42,"1025065-69-3",{"v":81,"d":"81.00"},199.79,"<1","N/A","http://selleckchem.com/products/SGI-1776.html","C20H22F3N5O","free base","N/A","CN1CCC(CC1)CNC2=N[N]3C(=NC=C3C4=CC=CC(=C4)OC(F)(F)F)C=C2",5.206,3,1,6]
["S2199","Aliskiren Hemifumarate","g8","L3000-08","in 10mM DMSO","RAAS","Endocrinology & Hormones","Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.",609.83,"173334-58-2",{"v":100,"d":"100.00"},163.98,{"v":100,"d":"100.00"},163.98,"http://selleckchem.com/products/Aliskiren-hemifumarate.html","C30H53N3O6.1/2C4H4O4","fumarate salt","CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.COCCCOC2=C(OC)C=CC(=C2)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.OC(=O)\\C=C\\C(O)=O",1.735,12,8,40]
["S2201","BMS-794833","h8","L3000-08","in 10mM DMSO","c-Met,RON,VEGFR","Protein Tyrosine Kinase","BMS-794833 is a potent ATP competitive inhibitor of Met (c-Met)/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.",468.84,"1174046-72-0",{"v":94,"d":"94.00"},200.49,"<1","N/A","http://selleckchem.com/products/BMS-794833.html","C23H15ClF2N4O3","free base","N/A","NC1=NC=CC(=C1Cl)OC2=CC=C(NC(=O)C3=CNC=C(C3=O)C4=CC=C(F)C=C4)C=C2F",{"v":2.85,"d":"2.850"},4,3,5]
["S2202","NVP-BHG712","a9","L3000-08","in 10mM DMSO","Bcr-Abl,Ephrin receptor,Raf,Src","Protein Tyrosine Kinase","NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.",503.48,"940310-85-0",{"v":101,"d":"101.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/NVP-BHG712.html","C26H20F3N7O","free base","N/A","C[N]1N=CC2=C1N=C(N=C2NC3=CC(=CC=C3C)C(=O)NC4=CC=CC(=C4)C(F)(F)F)C5=CC=CN=C5",4.871,5,2,6]
["S2205","OSI-420","b9","L3000-08","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","OSI-420 (DesMethyl Erlotinib, CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).",415.87,"183320-51-6",{"v":83,"d":"83.00"},199.58,"<1","N/A","http://selleckchem.com/products/OSI-420-Desmethyl-Erlotinib,CP-473420.html","C21H21N3O4.HCl","Hydrochloride","DesMethyl Erlotinib (CP-473420) HCl","Cl.COCCOC1=CC2=C(C=C1OCCO)C(=NC=N2)NC3=CC=CC(=C3)C#C",4.283,5,2,9]
["S2214","AZ 960","c9","L3000-08","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.",354.36,"905586-69-8",{"v":71,"d":"71.00"},200.36,"<1","N/A","http://selleckchem.com/products/AZ-960.html","C18H16F2N6","free base","N/A","CC(NC1=NC(=C(F)C=C1C#N)NC2=N[NH]C(=C2)C)C3=CC=C(F)C=C3",4.495,2,3,5]
["S2215","DAPT (GSI-IX)","d9","L3000-08","in 10mM DMSO","Apoptosis related,Autophagy,Beta Amyloid,Secretase","Proteases","DAPT (GSI-IX, LY-374973) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.",432.46,"208255-80-5",{"v":86,"d":"86.00"},198.86,"<1","N/A","http://selleckchem.com/products/DAPT-GSI-IX.html","C23H26F2N2O4","free base","LY-374973","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC(C(=O)OC(C)(C)C)C2=CC=CC=C2",3.385,4,2,9]
["S2216","Mubritinib (TAK 165)","e9","L3000-08","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line.",468.47,"366017-09-6",{"v":13,"d":"13.00"},27.75,"<1","N/A","http://selleckchem.com/products/Mubritinib-TAK-165.html","C25H23F3N4O2","free base","N/A","FC(F)(F)C1=CC=C(\\C=C\\C2=NC(=CO2)COC3=CC=C(CCCC[N]4C=CN=N4)C=C3)C=C1",5.844,5,0,11]
["S2217","Irinotecan (CPT-11) HCl Trihydrate","f9","L3000-08","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.",677.18,"136572-09-3",{"v":100,"d":"100.00"},147.67,{"v":1,"d":"1.00"},1.48,"http://selleckchem.com/products/Irinotecan-Hcl-Trihydrate-Campto.html","C33H38N4O6.HCl.3H2O","HCl & trihydrat","CPT-11 HCl Trihydrate","O.O.O.Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=CC=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C15)C(O)(CC)C(=O)OC4",3.446,6,0,5]
["S2218","Torkinib (PP242)","g9","L3000-08","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,mTOR","PI3K/Akt/mTOR","Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242) induces mitophagy and apoptosis.",308.34,"1092351-67-1",{"v":61,"d":"61.00"},197.83,"<1","N/A","http://selleckchem.com/products/PP242.html","C16H16N6O","free base","N/A","CC(C)[N]1N=C(C2=CC3=C([NH]2)C=CC(=C3)O)C4=C(N)N=CN=C14",2.908,3,3,2]
["S2219","Momelotinib (CYT387)","h9","L3000-08","in 10mM DMSO","Apoptosis related,Autophagy,JAK","JAK/STAT","Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.",414.46,"1056634-68-4",{"v":74,"d":"74.00"},178.55,"<1","N/A","http://selleckchem.com/products/Cyt387.html","C23H22N6O2","free base","LM-1149 , CYT11387","O=C(NCC#N)C1=CC=C(C=C1)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.857,4,2,6]
["S2220","SB590885","a10","L3000-08","in 10mM DMSO","Raf","MAPK","SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.",453.54,"405554-55-4",{"v":5,"d":"5.00"},11.02,"<1","N/A","http://selleckchem.com/products/SB590885.html","C27H27N5O2","free base","N/A","CN(C)CCOC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=C\\4C(=C3)CCC4=N\\O)C5=CC=NC=C5",4.503,4,1,7]
["S2222","PF-3716556","b10","L3000-08","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.",394.47,"928774-43-0",{"v":79,"d":"79.00"},200.27,"<1","N/A","http://selleckchem.com/products/PF-3716556.html","C22H26N4O3","Free Base","N/A","CN(CCO)C(=O)C1=C[N]2C=C(C)N=C2C(=C1)NC3CCOC4=CC=CC(=C34)C",1.499,3,2,5]
["S2224","UK 383367","c10","L3000-08","in 10mM DMSO","Procollagen C Proteinase","Metabolism","UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.",324.38,"348622-88-8",{"v":65,"d":"65.00"},200.38,"<1","N/A","http://selleckchem.com/products/UK-383367.html","C15H24N4O4","free base","N/A","NC(=O)C1=NOC(=N1)C(CCCC2CCCCC2)CC(=O)NO",1.731,5,2,8]
["S2225","TAME","d10","L3000-08","in 10mM DMSO","APC,E3 Ligase","Cell Cycle","Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.",342.41,"901-47-3",{"v":69,"d":"69.00"},201.51,{"v":69,"d":"69.00"},201.51,"http://selleckchem.com/products/TAME.html","C14H22N4O4S","free base","N/A","COC(=O)C(CCCNC(N)=N)N[S](=O)(=O)C1=CC=C(C)C=C1",0.749,4,3,10]
["S2226","Idelalisib","e10","L3000-08","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.",415.42,"870281-82-6",{"v":83,"d":"83.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/CAL-101.html","C22H18FN7O","free base","CAL-101, GS-1101","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=NC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)F",3.624,5,2,5]
["S2227","PIK-294","f10","L3000-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.",489.53,"900185-02-6",{"v":98,"d":"98.00"},200.19,"<1","N/A","http://selleckchem.com/products/PIK-294.html","C28H23N7O2","free base","N/A","CC1=C(C=CC=C1)N2C(=O)C3=C(C=CC=C3C)N=C2C[N]4N=C(C5=CC(=CC=C5)O)C6=C(N)N=CN=C46",4.867,5,2,4]
["S2228","Belnacasan (VX-765)","g10","L3000-08","in 10mM DMSO","Caspase","Apoptosis","Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.",{"v":509,"d":"509.00"},"273404-37-8",{"v":100,"d":"100.00"},196.46,"<1","N/A","http://selleckchem.com/products/VX-765.html","C24H33ClN4O6","free base","N/A","CCOC1OC(=O)CC1NC(=O)C2CCCN2C(=O)C(NC(=O)C3=CC(=C(N)C=C3)Cl)C(C)(C)C",1.698,6,3,8]
["S2229","Eltrombopag (SB497115) Olamine","h10","L3000-08","in 10mM DMSO","TpoR","Immunology & Inflammation","Eltrombopag Olamine (SB-497115-GR, Revolade, Promacta,Promacta Olamine) is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).",564.63,"496775-62-3",{"v":89,"d":"89.00"},157.63,"<1","N/A","http://selleckchem.com/products/Eltrombopag-SB-497115-GR.html","C29H36N6O6","diolamine","SB-497115-GR, Revolade, Promacta,Promacta Olamine","CC1=CC=C(C=C1C)N2N=C(C)C(=N/NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(O)=O)/C2=O.NCCO.NCCO",-0.151,4,6,7]
["S2230","Galunisertib (LY2157299)","a11","L3000-08","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Galunisertib (LY2157299) is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay. Phase 2/3.",369.42,"700874-72-2",{"v":74,"d":"74.00"},200.31,"<1","N/A","http://selleckchem.com/products/ly2157299.html","C22H19N5O","free base","N/A","CC1=CC=CC(=N1)C2=N[N]3CCCC3=C2C4=CC=NC5=C4C=C(C=C5)C(N)=O",3.095,4,1,3]
["S2231","Telatinib","b11","L3000-08","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. Phase 2.",409.83,"332012-40-5",{"v":82,"d":"82.00"},200.08,"<1","N/A","http://selleckchem.com/products/Telatinib-BAY-57-9352.html","C20H16ClN5O3","free base","BAY 57-9352","CNC(=O)C1=NC=CC(=C1)COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4",3.861,6,2,6]
["S2233","Esomeprazole sodium","c11","L3000-08","in 10mM DMSO","ATPase","Transmembrane Transporters","Esomeprazole Sodium((S)-Omeprazole sodium, (-)-Omeprazole sodium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.",{"v":367.4,"d":"367.40"},"161796-78-7",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://selleckchem.com/products/esomeprazole-sodium.html","C17H18N3O3S.Na","Sodium salt","(S)-Omeprazole sodium, (-)-Omeprazole sodium","COC1=CC=C2[N]([Na])C(=NC2=C1)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S2235","Volasertib (BI 6727)","d11","L3000-08","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.",618.81,"755038-65-4",{"v":20,"d":"20.00"},32.32,"<1","N/A","http://selleckchem.com/products/BI6727-Volasertib.html","C34H50N8O3","free base","N/A","CCC1N(C(C)C)C2=C(C=NC(=N2)NC3=CC=C(C=C3OC)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)N(C)C1=O",4.838,5,2,10]
["S2238","Palomid 529 (P529)","e11","L3000-08","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.",406.43,"914913-88-5",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/Palomid-529-P529.html","C24H22O6","free base","SG 00529","COC1=CC=C(COC2=C(OC)C=C3C(=C2)OC(=O)C4=C3C=CC(=C4)C(C)O)C=C1",4.257,5,1,6]
["S2243","Degrasyn (WP1130)","f11","L3000-08","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,DUB","Angiogenesis","Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.",384.27,"856243-80-6",{"v":77,"d":"77.00"},200.38,"<1","N/A","http://selleckchem.com/products/WP1130.html","C19H18BrN3O","free base","N/A","CCCC(NC(=O)/C(=C/C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",4.546,2,1,6]
["S2244","AR-42","g11","L3000-08","in 10mM DMSO","HDAC","Epigenetics","AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.",312.36,"935881-37-1",{"v":63,"d":"63.00"},201.69,"<1","N/A","http://selleckchem.com/products/AR-42-HDAC-42.html","C18H20N2O3","free base","HDAC-42","CC(C)C(C(=O)NC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",2.834,2,2,5]
["S2246","Abiraterone Acetate (CB7630)","h11","L3000-08","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Abiraterone Acetate (CB7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.",391.55,"154229-18-2",{"v":20,"d":"20.00"},51.08,"<1","N/A","http://www.selleck.cn/products/Abiraterone-Acetate-CB7630.html","C26H33NO2","Acetate","CB7630, CB-7630","CC(=O)OC1CCC2(C)C3CCC4(C)C(CC=C4C5=CC=CN=C5)C3CC=C2C1",4.602,3,0,3]
["S2247","Buparlisib (BKM120)","a2","L3000-09","in 10mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.",410.39,"944396-07-0",{"v":82,"d":"82.00"},199.81,"<1","N/A","http://selleckchem.com/products/BKM-120.html","C18H21F3N6O2","free base","NVP-BKM120","NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F",2.342,5,1,4]
["S2248","Silmitasertib (CX-4945)","b2","L3000-09","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase","Metabolism","Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.",349.77,"1009820-21-6",{"v":16,"d":"16.00"},45.74,"<1","N/A","http://selleckchem.com/products/cx-4945-silmitasertib.html","C19H12ClN3O2","free base","N/A","OC(=O)C1=CC2=C(C=C1)C3=CN=CC=C3C(=N2)NC4=CC(=CC=C4)Cl",4.157,3,1,3]
["S2250","(-)-Epigallocatechin Gallate","c2","L3000-09","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2252","(+)-Usniacin","d2","L3000-09","in 10mM DMSO","Others","Others","(+)-Usniacin (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.",344.32,"7562-61-0",{"v":4,"d":"4.00"},11.62,"<1","N/A","http://selleckchem.com/products/Usniacin-D-Usnic-acid.html","C18H16O7","free base","D-Usnic Acid","CC(=O)C1=C(O)C(=C(O)C2=C1OC3=CC(=O)C(=C(O)C23C)C(C)=O)C",1.087,4,3,2]
["S2254","4-Demethylepipodophyllotoxin(NSC-122819,VM-26)","e2","L3000-09","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.",400.38,"6559-91-7",{"v":80,"d":"80.00"},199.81,"N/A","N/A","http://selleckchem.com/products/4-Demethylepipodophyllotoxin.html","C21H20O8","free base","DMEP","COC1=C(O)C(=CC(=C1)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24)OC",1.886,6,2,3]
["S2256","4-Methylumbelliferone (4-MU)","f2","L3000-09","in 10mM DMSO","Others","Others","4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.",176.17,"90-33-5",{"v":35,"d":"35.00"},198.67,"<1","N/A","http://selleckchem.com/products/4-Methylumbelliferone(4-MU).html","C10H8O3","free base","N/A","CC1=CC(=O)OC2=C1C=CC(=C2)O",2.104,2,1,0]
["S2258","Esculin","g2","L3000-09","in 10mM DMSO","Others","Others","Esculin (Aesculin) is a glucoside found in horse chestnuts.",340.28,"531-75-9",{"v":68,"d":"68.00"},199.84,{"v":2,"d":"2.00"},5.88,"http://selleckchem.com/products/Aesculin(Esculin).html","C15H16O9","free base","Aesculin","OCC1OC(OC2=C(O)C=C3OC(=O)C=CC3=C2)C(O)C(O)C1O",-0.514,4,5,3]
["S2259","Aloe-emodin","h2","L3000-09","in 10mM DMSO","IFN","Immunology & Inflammation","Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.",270.24,"481-72-1",{"v":3,"d":"3.00"},{"v":11.1,"d":"11.10"},"<1","N/A","http://selleckchem.com/products/Aloe-emodin.html","C15H10O5","free base","NSC 38628, Rhabarberone","OCC1=CC2=C(C(=C1)O)C(=O)C3=C(C=CC=C3O)C2=O",1.719,2,3,1]
["S2260","Amygdalin","a3","L3000-09","in 10mM DMSO","Others","Others","Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.",457.43,"29883-15-6",{"v":91,"d":"91.00"},198.94,"<1","N/A","http://selleckchem.com/products/Amygdalin.html","C20H27NO11","free base","N/A","OCC1OC(OCC2OC(OC(C#N)C3=CC=CC=C3)C(O)C(O)C2O)C(O)C(O)C1O",-2.403,4,7,7]
["S2261","Andrographolide","b3","L3000-09","in 10mM DMSO","NF-κB","NF-κB","Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.",350.45,"5508-58-7",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/Andrographolide.html","C20H30O5","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C\\3C(O)COC3=O)C(=C)CCC12",2.056,2,3,3]
["S2262","Apigenin (LY 080400)","c3","L3000-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Apigenin (NSC 83244, LY 080400) is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.",270.24,"520-36-5",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Apigenin.html","C15H10O5","free base","NSC 83244","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",{"v":2.41,"d":"2.410"},2,3,1]
["S2263","Arbutin","d3","L3000-09","in 10mM DMSO","Tyrosinase","Proteases","Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.",272.25,"497-76-7",{"v":55,"d":"55.00"},202.02,{"v":55,"d":"55.00"},202.02,"http://selleckchem.com/products/Arbutin(Uva,-p-Arbutin).html","C12H16O7","free base","Uva,p-Arbutin, β-Arbutin","OCC1OC(OC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.584,2,5,3]
["S2264","Artemether","e3","L3000-09","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.",298.37,"71963-77-4",{"v":60,"d":"60.00"},201.09,"<1","N/A","http://selleckchem.com/products/Artemether(SM-224).html","C16H26O5","free base","SM-224, CGP 56696","COC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3",2.029,5,0,1]
["S2265","Artesunate (WR-256283)","f3","L3000-09","in 10mM DMSO","ADC Cytotoxin,STAT","JAK/STAT","Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.",384.42,"88495-63-0",{"v":77,"d":"77.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/Artesunate.html","C19H28O8","free base","WR-256283","CC1CCC2C(C)C(OC3OC4(C)CCC1C23OO4)OC(=O)CCC(O)=O",1.845,7,0,5]
["S2266","Asiatic Acid","g3","L3000-09","in 10mM DMSO","p38 MAPK","MAPK","Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.",{"v":488.7,"d":"488.70"},"464-92-6",{"v":97,"d":"97.00"},198.49,"<1","N/A","http://selleckchem.com/products/Asiatic-acid.html","C30H48O5","free base","Dammarolic acid, Asiantic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(O)=O",4.435,1,3,2]
["S2268","Baicalein","h3","L3000-09","in 10mM DMSO","P450 (e.g. CYP17),PREP","Metabolism","Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.",270.24,"491-67-8",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Baicalein.html","C15H10O5","free base","N/A","OC1=C(O)C(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)O",{"v":2.41,"d":"2.410"},2,3,1]
["S2269","Baicalin (NSC-661431)","a4","L3000-09","in 10mM DMSO","GABA Receptor,PREP","Neuronal Signaling","Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.",446.36,"21967-41-9",{"v":89,"d":"89.00"},199.39,"<1","N/A","http://selleckchem.com/products/Baicalin.html","C21H18O11","free base","N/A","OC1C(O)C(OC(C1O)C(O)=O)OC2=C(O)C(=C3C(=O)C=C(OC3=C2)C4=CC=CC=C4)O",0.608,5,5,4]
["S2270","Bergenin","b4","L3000-09","in 10mM DMSO","Others","Others","Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.",328.27,"477-90-7",{"v":66,"d":"66.00"},201.05,"<1","N/A","http://selleckchem.com/products/Bergenin-(Cuscutin).html","C14H16O9","free base","Cuscutin","COC1=C(O)C2=C(C=C1O)C(=O)OC3C(O)C(O)C(CO)OC23",-0.849,4,5,2]
["S2271","Berberine chloride (NSC 646666)","c4","L3000-09","in 10mM DMSO","Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase","Microbiology","Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.",371.81,"633-65-8",{"v":40,"d":"40.00"},107.58,"<1","N/A","http://selleckchem.com/products/Berberine-Hydrochloride.html","C20H18NO4.Cl","chloride","Natural Yellow 18 chloride","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4",1.289,4,0,2]
["S2277","Caffeic Acid","d4","L3000-09","in 10mM DMSO","Lipoxygenase,TRP Channel","Transmembrane Transporters","Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).",180.16,"331-39-5",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/Caffeic-acid.html","C9H8O4","free base","N/A","OC(=O)/C=C/C1=CC=C(O)C(=C1)O",1.443,1,2,2]
["S2280","Chlorogenic Acid","e4","L3000-09","in 10mM DMSO","Others","Others","Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.",354.31,"327-97-9",{"v":71,"d":"71.00"},200.39,{"v":18,"d":"18.00"},{"v":50.8,"d":"50.80"},"http://selleckchem.com/products/Chlorogenic-acid.html","C16H18O9","free base","NSC 407296, Heriguard","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S2281","Chrysin","f4","L3000-09","in 10mM DMSO","Others","Others","Chrysin (NSC 407436) is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).",254.24,"480-40-0",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Chrysin.html","C15H10O4","free base","NSC 407436","OC1=CC2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=CC=C3",2.652,2,2,1]
["S2283","Cinchonine(LA40221)","g4","L3000-09","in 10mM DMSO","5-alpha Reductase","Angiogenesis","Cinchonine (LA40221) is an alkaloid and a stereoisomer and pseudo-enantiomer of cinchonidine.",{"v":294.4,"d":"294.40"},"118-10-5",{"v":9,"d":"9.00"},30.57,"N/A","N/A","http://selleckchem.com/products/cinchonine.html","C19H22N2O","free base","N/A","OC(C1CC2CCN1CC2C=C)C3=CC=NC4=CC=CC=C34",{"v":2.75,"d":"2.750"},1,1,3]
["S2284","Colchicine (NSC 757)","h4","L3000-09","in 10mM DMSO","Microtubule Associated","Cell Cycle","Colchicine (NSC 757, Colchineos, Colchisol, Colcin) is a microtubule polymerization inhibitor with an IC50 of 3 nM.",399.44,"64-86-8",{"v":80,"d":"80.00"},200.28,{"v":80,"d":"80.00"},200.28,"http://selleckchem.com/products/colchicine.html","C22H25NO6","free base","Colchineos, Colchisol, Colcin,NSC 757","COC1=CC=C2C(=CC1=O)C(CCC3=C2C(=C(OC)C(=C3)OC)OC)NC(C)=O",2.044,6,1,5]
["S2285","Cryptotanshinone","a5","L3000-09","in 10mM DMSO","Apoptosis related,Autophagy,STAT","JAK/STAT","Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.",296.36,"35825-57-1",{"v":5,"d":"5.00"},16.87,"<1","N/A","http://selleckchem.com/products/Cryptotanshinone.html","C19H20O3","free base","Tanshinone C","CC1COC2=C1C(=O)C(=O)C3=C4CCCC(C)(C)C4=CC=C23",3.761,3,0,0]
["S2286","Cyclosporin A (NSC 290193)","b5","L3000-09","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Complement System,Immunology & Inflammation related,phosphatase","Immunology & Inflammation","Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.",1202.61,"59865-13-3",{"v":100,"d":"100.00"},83.15,"<1","N/A","http://selleckchem.com/products/Cyclosporin-A(Cyclosporine-A).html","C62H111N11O12","free base","Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193","CCC1NC(=O)C(C(O)C(C)C\\C=C\\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C",4.333,11,5,15]
["S2287","Cytisine","c5","L3000-09","in 10mM DMSO","AChR","Neuronal Signaling","Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.",190.24,"485-35-8",{"v":38,"d":"38.00"},199.75,{"v":38,"d":"38.00"},199.75,"http://selleckchem.com/products/Cytisine(Baphitoxine,-Sophorine).html","C11H14N2O","free base","Baphitoxine,Sophorine","O=C1C=CC=C2C3CNCC(C3)CN12",-0.338,1,1,0]
["S2289","Daidzin","d5","L3000-09","in 10mM DMSO","Dehydrogenase","Metabolism","Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside), a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).",416.38,"552-66-9",{"v":83,"d":"83.00"},199.34,"<1","N/A","http://selleckchem.com/products/Daidzin.html","C21H20O9","Free Base","Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside","OCC1OC(OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",0.452,4,5,4]
["S2290","Dihydroartemisinin (DHA)","e5","L3000-09","in 10mM DMSO","Apoptosis related,Autophagy,NF-κB","NF-κB","Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.",284.35,"71939-50-9",{"v":56,"d":"56.00"},196.94,"<1","N/A","http://selleckchem.com/products/Dihydroartemisinin(DHA).html","C15H24O5","free base","Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol","CC1CCC2C(C)C(O)OC3OC4(C)CCC1C23OO4",1.621,4,0,0]
["S2295","Emodin","f5","L3000-09","in 10mM DMSO","Dehydrogenase","Metabolism","Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).",270.24,"518-82-1",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Emodin.html","C15H10O5","free base","N/A","CC1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(O)C=C3O)C2=O",2.568,2,3,0]
["S2296","Enoxolone","g5","L3000-09","in 10mM DMSO","Dehydrogenase","Metabolism","Enoxolone (Glycyrrhetin) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.",470.68,"471-53-4",{"v":94,"d":"94.00"},199.71,"<1","N/A","http://selleckchem.com/products/Enoxolone(Glycyrrhetin).html","C30H46O4","free base","Glycyrrhetin","CC1(C)C(O)CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.656,2,1,1]
["S2298","Fisetin","h5","L3000-09","in 10mM DMSO","Sirtuin","Epigenetics","Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.",286.24,"528-48-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","http://selleckchem.com/products/Fisetin(Fustel).html","C15H10O6","free base","N/A","OC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC(=C(O)C=C3)O)O",1.872,2,4,1]
["S2299","Formononetin","a6","L3000-09","in 10mM DMSO","Others","Endocrinology & Hormones","Formononetin (Formononetol, Biochanin B) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone.",268.26,"485-72-3",{"v":54,"d":"54.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/Formononetin(Formononetol).html","C16H12O4","free base","Formononetol, Biochanin B","COC1=CC=C(C=C1)C2=COC3=C(C=CC(=C3)O)C2=O",2.608,3,1,2]
["S2300","Ferulic Acid","b6","L3000-09","in 10mM DMSO","FGFR","Angiogenesis","Ferulic Acid (Fumalic) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong. Ferulic acid is a novel fibroblast growth factor receptor (FGFR) inhibitor with IC50s of 3.78 μM and 12.5 μM for FGFR1 and FGFR2, respectively.",194.19,"1135-24-6",{"v":39,"d":"39.00"},200.83,"<1","N/A","http://selleckchem.com/products/Fumalic-acid(Ferulic-acid).html","C10H10O4","free base","Fumalic Acid","COC1=CC(=CC=C1O)\\C=C\\C(O)=O",1.669,2,1,3]
["S2301","Genistin (Genistoside)","c6","L3000-09","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Genistin (Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside) is an isoflavone found in a number of dietary plants like soy and kudzu. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of Estrogen Receptor α (ERα) signaling pathway.",432.37,"529-59-9",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Genistin(Genistoside).html","C21H20O10","free base","Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S2302","Glycyrrhizin (NSC 167409)","d6","L3000-09","in 10mM DMSO","Dehydrogenase,High-mobility Group,MAO","Metabolism","Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).",822.93,"1405-86-3",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Glycyrrhizic-acid.html","C42H62O16","free base","N/A","CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",2.417,8,5,7]
["S2303","Gossypol Acetate","e6","L3000-09","in 10mM DMSO","Dehydrogenase","Metabolism","Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.",578.61,"12542-36-8",{"v":100,"d":"100.00"},172.83,"<1","N/A","https://www.selleckchem.com/products/gossypol-acetate.html","C32H34O10","Acetate","Gossypol Acetic acid, Pogosin, AT101","CC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(=C1O)O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C.CC(O)=O",6.388,3,6,5]
["S2304","Gramine","f6","L3000-09","in 10mM DMSO","ADC Cytotoxin,AdipoR,Adrenergic Receptor","Metabolism","Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist.",174.24,"87-52-5",{"v":35,"d":"35.00"},200.87,"<1","N/A","http://selleckchem.com/products/Gramine.html","C11H14N2","free base","N/A","CN(C)CC1=C[NH]C2=C1C=CC=C2",2.197,0,1,2]
["S2305","Grape Seed Extract","g6","L3000-09","in 10mM DMSO","Others","Others","Grape Seed Extract are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs.","N/A","84929-27-1",{"v":94,"d":"94.00"},{"v":10,"d":"10.00"},"<1","N/A","http://selleckchem.com/products/Grape-Seed-Extract.html","N/A","Polyphenols","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S2306","Gynostemma Extract","h6","L3000-09","in 10mM DMSO","Others","Others","Gynostemma Extract (Gynostemma Pentaphyllum, Gypenoside) is a saponins extract derived from the Gynostemma pentaphyllum.",917.13,"80321-63-7",{"v":189,"d":"189.00"},206.08,"<1","N/A","http://selleckchem.com/products/Gynostemma-Extract.html","C48H82O18","free base","Gynostemma Pentaphyllum, Gypenoside","CC(C)=CCCC(C)(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7O)C(C)(C)C6CCC45C",1.059,6,11,12]
["S2308","Hesperetin","a7","L3000-09","in 10mM DMSO","Histamine Receptor,TGF-beta/Smad","TGF-beta/Smad","Hesperetin is a bioflavonoid and, to be more specific, a flavanone.",302.27,"520-33-2",{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/Hesperetin.html","C16H14O6","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.357,3,3,2]
["S2309","Hesperidin","b7","L3000-09","in 10mM DMSO","Others","Others","Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits.",610.56,"520-26-3",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/Hesperidin.html","C28H34O15","free base","Cirantin","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",-0.431,7,8,7]
["S2310","Honokiol (NSC 293100)","c7","L3000-09","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2311","Hyodeoxycholic acid (HDCA)","d7","L3000-09","in 10mM DMSO","GPCR19","GPCR & G Protein","Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.",392.57,"83-49-8",{"v":78,"d":"78.00"},198.69,"<1","N/A","http://selleckchem.com/products/Hyodeoxycholic-acid(HDCA).html","C24H40O4","free base","NSC 60672","CC(CCC(O)=O)C1CCC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C",4.014,1,2,4]
["S2312","Icariin","e7","L3000-09","in 10mM DMSO","PDE","Metabolism","Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.",676.66,"489-32-7",{"v":50,"d":"50.00"},73.89,"<1","N/A","http://selleckchem.com/products/Icariin.html","C33H40O15","free base","N/A","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O2)C(=C(OC5OC(CO)C(O)C(O)C5O)C=C4O)CC=C(C)C",0.983,7,8,9]
["S2313","Indole-3-carbinol","f7","L3000-09","in 10mM DMSO","NF-κB","NF-κB","Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.",147.18,"700-06-1",{"v":29,"d":"29.00"},197.04,{"v":7,"d":"7.00"},47.56,"http://selleckchem.com/products/Indole-3-carbinol.html","C9H9NO","free base","N/A","OCC1=C[NH]C2=C1C=CC=C2",1.518,0,2,1]
["S2314","Kaempferol (NSC 407289)","g7","L3000-09","in 10mM DMSO","Estrogen/progestogen Receptor,Fatty Acid Synthase","Endocrinology & Hormones","Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.",286.23,"520-18-3",{"v":57,"d":"57.00"},199.14,"<1","N/A","http://selleckchem.com/products/Kaempferol.html","C15H10O6","free base","Robigenin","OC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.872,2,4,1]
["S2318","Lappaconitine","h7","L3000-09","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc.",{"v":584.7,"d":"584.70"},"32854-75-4",{"v":16,"d":"16.00"},27.36,"N/A","N/A","http://selleckchem.com/products/lappaconitine.html","C32H44N2O8","free base","N/A","CCN1CC2(CCC(OC)C34C2CC(C13)C5(O)CC(OC)C6CC4C5(O)C6OC)OC(=O)C7=CC=CC=C7NC(C)=O",0.029,6,1,8]
["S2319","Limonin","a8","L3000-09","in 10mM DMSO","HIV Protease","Microbiology","Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.",470.51,"1180-71-8",{"v":44,"d":"44.00"},93.52,"<1","N/A","http://selleckchem.com/products/Limonin.html","C26H30O8","free base","N/A","CC1(C)OC2CC(=O)OCC23C4CCC5(C)C(OC(=O)C6OC56C4(C)C(=O)CC13)C7=COC=C7",1.447,8,0,1]
["S2320","Luteolin","b8","L3000-09","in 10mM DMSO","ADC Cytotoxin,PDE","Metabolism","Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.",286.24,"491-70-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/luteolin.html","C15H10O6","free base","Luteoline, Luteolol, Digitoflavone","OC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=C(O)C(=C3)O)O",2.168,2,4,1]
["S2321","Magnolol","c8","L3000-09","in 10mM DMSO","Fungal,NF-κB","NF-κB","Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.",266.33,"528-43-8",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Magnolol(2,2-Bichavicol).html","C18H18O2","free base","NSC 293099","OC1=C(C=C(CC=C)C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2322","(+)-Matrine","d8","L3000-09","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.",248.36,"519-02-8",{"v":49,"d":"49.00"},197.29,{"v":11,"d":"11.00"},44.29,"http://selleckchem.com/products/matrine.html","C15H24N2O","free base","N/A","O=C1CCCC2C3CCCN4CCCC(CN12)C34",1.417,1,0,0]
["S2323","Methyl-Hesperidin","e8","L3000-09","in 10mM DMSO","Akt,PKC","PI3K/Akt/mTOR","Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.",624.59,"11013-97-1",{"v":100,"d":"100.00"},155.62,{"v":100,"d":"100.00"},155.62,"http://selleckchem.com/products/Methyl-Hesperidin.html","C29H36O15","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(OC)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",{"v":-0.79,"d":"-0.790"},7,8,7]
["S2325","Morin Hydrate","f8","L3000-09","in 10mM DMSO","Others","Others","Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).",320.25,"6202-27-3",{"v":64,"d":"64.00"},199.84,"<1","N/A","https://www.selleckchem.com/products/Morin-hydrate.html","C15H10O7.H2O","Hydrate","Aurantica","O.OC1=CC=C(C(=C1)O)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.423,2,5,1]
["S2326","Myricetin","g8","L3000-09","in 10mM DMSO","MEK","MAPK","Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.",318.24,"529-44-2",{"v":63,"d":"63.00"},197.96,"<1","N/A","http://selleckchem.com/products/Myricetin(Cannabiscetin).html","C15H10O8","free base","Cannabiscetin","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O)O",1.388,2,6,1]
["S2327","Myricitrin","h8","L3000-09","in 10mM DMSO","PKC","TGF-beta/Smad","Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.",464.38,"17912-87-7",{"v":93,"d":"93.00"},200.27,"<1","N/A","http://selleckchem.com/products/Myricitrin(Myricitrine).html","C21H20O12","free base","Myricitrine","CC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C(=C4)O)O)C(O)C(O)C1O",0.347,4,8,3]
["S2328","Nalidixic acid","a9","L3000-09","in 10mM DMSO","Selection Antibiotics for Transfected Cell,Topoisomerase","DNA Damage/DNA Repair","Nalidixic acid (NSC-82174) is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.",232.24,"389-08-2",{"v":6,"d":"6.00"},25.84,"<1","N/A","http://selleckchem.com/products/Nalidixic-acid(NegGram).html","C12H12N2O3","free base","NSC-82174","CCN1C=C(C(O)=O)C(=O)C2=C1N=C(C)C=C2",1.176,3,0,2]
["S2329","Naringin","b9","L3000-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.",580.53,"10236-47-2",{"v":100,"d":"100.00"},172.26,"<1","N/A","http://selleckchem.com/products/Naringin(Naringoside).html","C27H32O14","free base","Naringoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C=C5)O)C(O)C(O)C1O",-0.415,6,8,6]
["S2332","Neohesperidin","c9","L3000-09","in 10mM DMSO","ROS","Immunology & Inflammation","Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent., Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。",610.56,"13241-33-3",{"v":122,"d":"122.00"},199.82,"<1","N/A","http://selleckchem.com/products/Neohesperidin.html","C28H34O15","free base","NSC 31048","COC1=CC(=CC(=C1)C2CC(=O)C3=C(O)C=C(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)C=C3O2)O",-0.431,7,8,7]
["S2333","Nobiletin (NSC 76751)","d9","L3000-09","in 10mM DMSO","MMP","Proteases","Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.",402.39,"478-01-3",{"v":81,"d":"81.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/Nobiletin(Hexamethoxyflavone).html","C21H22O8","free base","Hexamethoxyflavone","COC1=C(OC)C=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.038,8,0,7]
["S2334","Oleanolic Acid","e9","L3000-09","in 10mM DMSO","Antiviral","Microbiology","Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.",{"v":456.7,"d":"456.70"},"508-02-1",{"v":21,"d":"21.00"},45.98,"<1","N/A","http://selleckchem.com/products/Oleanolic-Acid(Caryophyllin).html","C30H48O3","free base","Caryophyllin","CC1(C)CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",6.282,1,1,1]
["S2335","Oridonin (NSC-250682)","f9","L3000-09","in 10mM DMSO","Akt,Bacterial","PI3K/Akt/mTOR","Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.",364.43,"28957-04-2",{"v":72,"d":"72.00"},197.57,"<1","N/A","http://selleckchem.com/products/Oridonin(Isodonol).html","C20H28O6","free base","Isodonol, Rubescenin","CC1(C)CCC(O)C23COC(O)(C(O)C12)C45C(O)C(CCC34)C(=C)C5=O",{"v":0.2,"d":"0.200"},2,3,0]
["S2336","Orotic acid (6-Carboxyuracil)","g9","L3000-09","in 10mM DMSO","Others","Others","Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.",{"v":156.1,"d":"156.10"},"65-86-1",{"v":2,"d":"2.00"},12.81,"<1","N/A","http://selleckchem.com/products/Orotic-acid(6-Carboxyuracil).html","C5H4N2O4","free base","N/A","OC(=O)C1=CC(=O)NC(=O)N1",-1.152,3,2,1]
["S2337","Osthole","h9","L3000-09","in 10mM DMSO","Others","Others","Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.",244.29,"484-12-8",{"v":49,"d":"49.00"},200.58,"<1","N/A","http://selleckchem.com/products/Osthole(Osthol).html","C15H16O3","free base","Osthol","COC1=CC=C2C=CC(=O)OC2=C1CC=C(C)C",{"v":3.74,"d":"3.740"},3,0,3]
["S2338","Oxymatrine","a10","L3000-09","in 10mM DMSO","Immunology & Inflammation related","TGF-beta/Smad","Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.",264.36,"16837-52-8",{"v":53,"d":"53.00"},200.48,{"v":53,"d":"53.00"},200.48,"http://selleckchem.com/products/Oxymatrine(Matrine-N-oxide).html","C15H24N2O2","free base","Matrine N-oxide","[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23",{"v":0.61,"d":"0.610"},1,0,0]
["S2341","(-)-Parthenolide","b10","L3000-09","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2342","Phloretin (RJC 02792)","c10","L3000-09","in 10mM DMSO","SGLT","GPCR & G Protein","Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.",274.27,"60-82-2",{"v":54,"d":"54.00"},196.89,"<1","N/A","http://selleckchem.com/products/Phloretin(Dihydronaringenin).html","C15H14O5","free base","NSC 407292, Dihydronaringenin","OC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1",2.757,1,4,4]
["S2344","Piperine","d10","L3000-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.",285.34,"94-62-2",{"v":57,"d":"57.00"},199.76,"<1","N/A","http://selleckchem.com/products/Piperine(1-Piperoylpiperidine).html","C17H19NO3","free base","1-Piperoylpiperidine","O=C(\\C=C\\C=C\\C1=CC2=C(OCO2)C=C1)N3CCCCC3",2.864,3,0,3]
["S2346","Puerarin","e10","L3000-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.",416.38,"3681-99-0",{"v":86,"d":"86.00"},206.54,"<1","N/A","http://selleckchem.com/products/Puerarin(Kakonein).html","C21H20O9","free base","Kakonein","OCC1OC(OC2=C(O)C=CC3=C2OC=C(C3=O)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S2347","Quercetin Dihydrate","f10","L3000-09","in 10mM DMSO","PI3K,Sirtuin","PI3K/Akt/mTOR","Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.",338.27,"6151-25-3",{"v":67,"d":"67.00"},198.07,"<1","N/A","http://selleckchem.com/products/Quercetin-dihydrate(Sophoretin).html","C15H10O7.2H2O","Dihydrate","Sophoretin","O.O.OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",1.216,2,5,1]
["S2348","Rotenone (Barbasco)","g10","L3000-09","in 10mM DMSO","Apoptosis related,Mitochondrial Metabolism,Mitophagy,NADPH-oxidase,ROS","Immunology & Inflammation","Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.",394.42,"83-79-4",{"v":78,"d":"78.00"},197.76,"N/A","N/A","http://selleckchem.com/products/rotenone-barbasco.html","C23H22O6","free base","Barbasco, Dactinol, Paraderil, Rotenon, Rotocide","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C(C=CC5=C4CC(O5)C(C)=C)C3=O",{"v":3.93,"d":"3.930"},6,0,3]
["S2349","Rutaecarpine","h10","L3000-09","in 10mM DMSO","COX","Neuronal Signaling","Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.",287.32,"84-26-4",{"v":24,"d":"24.00"},83.53,"<1","N/A","http://selleckchem.com/products/Rutaecarpine(Rutecarpine).html","C18H13N3O","free base","Rutecarpine","O=C1N2CCC3=C([NH]C4=C3C=CC=C4)C2=NC5=C1C=CC=C5",3.359,2,1,0]
["S2350","Rutin","a11","L3000-09","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1","N/A","http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2351","Salicin","b11","L3000-09","in 10mM DMSO","COX","Neuronal Signaling","Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.",286.28,"138-52-3",{"v":57,"d":"57.00"},199.11,{"v":24,"d":"24.00"},83.83,"http://selleckchem.com/products/Salicin(Salicoside,-Salicine).html","C13H18O7","free base","Salicoside,Salicine","OCC1OC(OC2=CC=CC=C2CO)C(O)C(O)C1O",-0.947,2,5,4]
["S2354","Sclareol","c11","L3000-09","in 10mM DMSO","Others","Others","Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.",{"v":308.5,"d":"308.50"},"515-03-7",{"v":61,"d":"61.00"},197.73,"<1","N/A","http://selleckchem.com/products/Sclareol.html","C20H36O2","free base","N/A","CC1(C)CCCC2(C)C1CCC(C)(O)C2CCC(C)(O)C=C",{"v":4.27,"d":"4.270"},0,0,4]
["S2357","Silibinin (NSC 651520)","d11","L3000-09","in 10mM DMSO","Others","Others","Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.",482.44,"22888-70-6",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silibinin(Silybin).html","C25H22O10","free base","Silybin, Silibinin A, Silymarin I, Flavobin","COC1=CC(=CC=C1O)C2OC3=CC(=CC=C3OC2CO)C4OC5=CC(=CC(=C5C(=O)C4O)O)O",2.592,5,5,4]
["S2358","Silymarin","e11","L3000-09","in 10mM DMSO","Antioxidant","Angiogenesis","Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.",482.44,"65666-07-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silymarin(Silybin-B).html","C25H22O10","free base","Silybin B","COC1=CC(=CC=C1O)C2OC3=CC=C(C=C3OC2CO)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S2362","Synephrine","f11","L3000-09","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.",167.21,"94-07-5",{"v":33,"d":"33.00"},197.36,"<1","N/A","http://selleckchem.com/products/Synephrine(Oxedrine).html","C9H13NO2","free base","Oxedrine","CNCC(O)C1=CC=C(O)C=C1",0.615,0,3,3]
["S2363","Tangeretin","g11","L3000-09","in 10mM DMSO","Antioxidant","Apoptosis","Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.",372.37,"481-53-8",{"v":8,"d":"8.00"},21.48,"<1","N/A","http://selleckchem.com/products/Tangeretin(Tangeritin).html","C20H20O7","free base","Tangeritin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.054,7,0,6]
["S2364","Tanshinone I","h11","L3000-09","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.",276.29,"568-73-0",{"v":23,"d":"23.00"},83.25,"<1","N/A","http://selleckchem.com/products/Tanshinone-I.html","C18H12O3","free base","N/A","CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C)C=CC=C34",4.084,3,0,0]
["S2365","Tanshinone IIA","a2","L3000-10","in 10mM DMSO","Lipase","Metabolism","Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.",294.34,"568-72-9",{"v":5,"d":"5.00"},16.99,"<1","N/A","http://selleckchem.com/products/Tanshinone-IIA(Tanshinone-B).html","C19H18O3","free base","Tanshinone B","CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C",{"v":4.66,"d":"4.660"},3,0,0]
["S2366","Taxifolin (Dihydroquercetin)","b2","L3000-10","in 10mM DMSO","VEGFR","Angiogenesis","Taxifolin, type I inhibitor for VEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.",304.25,"480-18-2",{"v":60,"d":"60.00"},197.21,"<1","N/A","http://selleckchem.com/products/Taxifolin(Dihydroquercetin).html","C15H12O7","free base","N/A","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C=C3)O",1.479,2,5,1]
["S2369","Troxerutin","c2","L3000-10","in 10mM DMSO","NLR,ROS","Immunology & Inflammation","Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.",742.68,"7085-55-4",{"v":100,"d":"100.00"},134.65,{"v":100,"d":"100.00"},134.65,"http://selleckchem.com/products/Troxerutin.html","C33H42O19","free base","N/A","CC1OC(OCC2OC(OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(OCCO)C=C5)OCCO)C(O)C(O)C2O)C(O)C(O)C1O",{"v":-2.1,"d":"-2.100"},9,10,15]
["S2370","Ursolic Acid","d2","L3000-10","in 10mM DMSO","Others","Others","Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.",{"v":456.7,"d":"456.70"},"77-52-1",{"v":91,"d":"91.00"},199.26,"<1","N/A","http://selleckchem.com/products/Ursolic-acid(Malol).html","C30H48O3","free base","NSC 167406, NSC-4060, Prunol, Urson, Malol","CC1CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",6.327,1,1,1]
["S2371","Vanillylacetone","e2","L3000-10","in 10mM DMSO","NF-κB","NF-κB","Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.",194.23,"122-48-5",{"v":38,"d":"38.00"},195.64,{"v":10,"d":"10.00"},51.49,"http://selleckchem.com/products/Vanillylacetone.html","C11H14O3","free base","NSC 15335","COC1=CC(=CC=C1O)CCC(C)=O",1.792,2,1,4]
["S2375","Aloin","f2","L3000-10","in 10mM DMSO","Tyrosinase","Proteases","Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.",418.39,"1415-73-2",{"v":83,"d":"83.00"},198.38,{"v":83,"d":"83.00"},198.38,"http://selleckchem.com/products/Aloin(Barbaloin).html","C21H22O9","free base","Barbaloin, Barbalin","OCC1OC(C(O)C(O)C1O)C2C3=C(C(=CC=C3)O)C(=O)C4=C2C=C(CO)C=C4O",-0.404,2,7,3]
["S2376","Ammonium Glycyrrhizinate","g2","L3000-10","in 10mM DMSO","Dehydrogenase,High-mobility Group","Metabolism","Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.",839.96,"1407-03-0",{"v":168,"d":"168.00"},200.01,{"v":5,"d":"5.00"},5.95,"http://selleckchem.com/products/Ammonium-Glycyrrhizinate(AMGZ).html","C42H62O16.NH3","Glycyrrhizic acid salt","AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt","N.CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",-0.915,8,5,7]
["S2377","Biochanin A","h2","L3000-10","in 10mM DMSO","FAAH","Metabolism","Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.",284.26,"491-80-5",{"v":57,"d":"57.00"},200.52,"<1","N/A","http://selleckchem.com/products/Biochanin-A(4-Methylgenistein).html","C16H12O5","free base","4-Methylgenistein","COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O",2.366,3,2,2]
["S2378","Butylscopolamine Bromide","a3","L3000-10","in 10mM DMSO","AChR","Neuronal Signaling","Butylscopolamine Bromide (Scopolamine Butylbromide,(-)-Scopolamine butylbromide, Hyoscine butylbromide), is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.",440.37,"149-64-4",{"v":88,"d":"88.00"},199.83,{"v":88,"d":"88.00"},199.83,"http://selleckchem.com/products/butylscopolamine-bromide.html","C21H30NO4.Br","Bromide","Scopolamine Butylbromide,(-)-Scopolamine butylbromide, Hyoscine butylbromide","[Br-].CCCC[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",{"v":-1.62,"d":"-1.620"},3,1,8]
["S2379","Dioscin","b3","L3000-10","in 10mM DMSO","Others","Others","Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.",869.04,"19057-60-4",{"v":100,"d":"100.00"},115.07,"<1","N/A","http://selleckchem.com/products/Dioscin(Collettiside-III).html","C45H72O16","free base","Collettiside III, Saponin","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",1.169,8,8,7]
["S2380","Diosmetin","c3","L3000-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants.",300.26,"520-34-3",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://selleckchem.com/products/Diosmetin(Luteolin-4-methyl-ether).html","C16H12O6","free base","Luteolin 4-methyl ether","COC1=CC=C(C=C1O)C2=CC(=O)C3=C(O)C=C(O)C=C3O2",2.394,3,3,2]
["S2382","Evodiamine","d3","L3000-10","in 10mM DMSO","NF-κB","NF-κB","Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.",303.36,"518-17-2",{"v":12,"d":"12.00"},39.56,"<1","N/A","http://www.selleck.cn/products/Evodiamine(Isoevodiamine).html","C19H17N3O","Free Base","Isoevodiamine","CN1C2N(CCC3=C2[NH]C4=CC=CC=C34)C(=O)C5=C1C=CC=C5",3.673,1,1,0]
["S2383","Gastrodin","e3","L3000-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.",286.28,"62499-27-8",{"v":50,"d":"50.00"},174.65,"<1","N/A","http://selleckchem.com/products/Gastrodin(Gastrodine).html","C13H18O7","free base","Gastrodine","OCC1OC(OC2=CC=C(CO)C=C2)C(O)C(O)C1O",-0.947,2,5,4]
["S2386","Indirubin (NSC 105327)","f3","L3000-10","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Indirubin (NSC 105327) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.",262.26,"479-41-4",{"v":53,"d":"53.00"},202.09,"<1","N/A","http://selleckchem.com/products/Indirubin.html","C16H10N2O2","free base","NSC 105327","O=C1NC2=CC=CC=C2\\C1=C3/NC4=C(C=CC=C4)C3=O",1.876,2,2,0]
["S2387","Lappaconite HBr","g3","L3000-10","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.",665.61,"97792-45-5",{"v":28,"d":"28.00"},42.07,"<1","N/A","http://selleckchem.com/products/Lappaconite-Hydrobromide.html","C32H44N2O8.HBr","Hydrobromide","N/A","Br.CCN1CC2(CCC(OC)C34C2CC(C13)C5(O)CC(OC)C6CC4C5(O)C6OC)OC(=O)C7=C(NC(C)=O)C=CC=C7",{"v":0.52,"d":"0.520"},6,1,8]
["S2388","L-carnitine","h3","L3000-10","in 10mM DMSO","Others","Others","L-carnitine (Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine) is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.",{"v":161.2,"d":"161.20"},"541-15-1",{"v":12,"d":"12.00"},74.44,{"v":32,"d":"32.00"},198.51,"http://selleckchem.com/products/L-carnitine(Levocarnitine).html","C7H15NO3","quaternary-N  salt","Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine","C[N+](C)(C)CC(O)CC([O-])=O",{"v":-3.29,"d":"-3.290"},0,1,4]
["S2389","Naringin Dihydrochalcone","a4","L3000-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.",582.55,"18916-17-1",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://selleckchem.com/products/Naringin-Dihydrochalcone(Naringin-DC).html","C27H34O14","free base","N/A","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C(C(=O)CCC4=CC=C(O)C=C4)C(=C3)O)O)C(O)C(O)C1O",-0.032,5,9,9]
["S2390","Polydatin","b4","L3000-10","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.",390.38,"65914-17-2",{"v":78,"d":"78.00"},199.81,"<1","N/A","http://selleckchem.com/products/Polydatin(Piceid).html","C20H22O8","free base","Piceid","OCC1OC(OC2=CC(=CC(=C2)\\C=C\\C3=CC=C(O)C=C3)O)C(O)C(O)C1O",{"v":1.16,"d":"1.160"},2,6,5]
["S2391","Quercetin (NSC 9221)","c4","L3000-10","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src","Epigenetics","Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.",302.24,"117-39-5",{"v":61,"d":"61.00"},201.83,"<1","N/A","http://selleckchem.com/products/Quercetin(Sophoretin).html","C15H10O7","Free Base","Sophoretin, C.I. 75720","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S2394","Naringenin","d4","L3000-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.",272.25,"480-41-1",{"v":54,"d":"54.00"},198.35,"<1","N/A","http://selleckchem.com/products/naringenin.html","C15H12O5","free base","NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["S2396","Salidroside","e4","L3000-10","in 10mM DMSO","Mitophagy,mTOR,PREP","PI3K/Akt/mTOR","Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.",{"v":300.3,"d":"300.30"},"10338-51-9",{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Salidroside-Rhodioloside.html","C14H20O7","free base","Rhodioloside","OCC1OC(OCCC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.443,2,5,5]
["S2397","Palmatine chloride","f4","L3000-10","in 10mM DMSO","Calcium Channel","Neuronal Signaling","Palmatine hydrochloride (Palmatine chloride (6CI,7CI); Fibrauretin) is a hydrochloride salt of palmatine which is a protoberberine alkaloid.",387.86,"10605-02-4",{"v":77,"d":"77.00"},198.53,{"v":5,"d":"5.00"},12.89,"http://selleckchem.com/products/Palmatine-chloride.html","C21H22NO4.Cl","Chloride","N/A","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC",1.488,4,0,4]
["S2399","Dihydromyricetin","g4","L3000-10","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2400","Rheic Acid","h4","L3000-10","in 10mM DMSO","FTO,Immunology & Inflammation related","Immunology & Inflammation","Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.",284.22,"478-43-3",{"v":3,"d":"3.00"},10.56,"<1","N/A","http://www.selleck.cn/products/Rhein-Monorhein.html","C15H8O6","Free Base","Rhein, Monorhein, NSC 38629, Rheinic Acid","OC(=O)C1=CC(=C2C(=O)C3=C(C=CC=C3O)C(=O)C2=C1)O",1.954,3,2,1]
["S2401","Sodium Danshensu","a5","L3000-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.",220.15,"67920-52-9",{"v":7,"d":"7.00"},{"v":31.8,"d":"31.80"},{"v":2,"d":"2.00"},9.08,"http://selleckchem.com/products/Sodium-Danshensu.html","C9H9O5.Na","Sodium Salt","N/A","[Na+].OC(CC1=CC(=C(O)C=C1)O)C([O-])=O",-0.795,0,3,3]
["S2403","Tetrandrine (NSC-77037)","b5","L3000-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.",622.75,"518-34-3",{"v":7,"d":"7.00"},11.24,"<1","N/A","http://www.selleck.cn/products/Tetrandrine-Fanchinine.html","C38H42N2O6","Free Base","Fanchinine, d-Tetrandrine","COC1=CC=C2CC3N(C)CCC4=CC(=C(OC)C(=C34)OC5=C(OC)C=C6CCN(C)C(CC7=CC=C(OC1=C2)C=C7)C6=C5)OC",7.218,6,0,4]
["S2404","Isoliquiritigenin","c5","L3000-10","in 10mM DMSO","Aldose Reductase","Metabolism","Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.",256.25,"961-29-5",{"v":12,"d":"12.00"},46.83,"<1","N/A","http://selleckchem.com/products/Isoliquiritigenin.html","C15H12O4","free base","N/A","OC1=CC=C(C=C1)\\C=C\\C(=O)C2=C(O)C=C(O)C=C2",2.975,1,3,3]
["S2405","Sophocarpine","d5","L3000-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.",246.35,"6483-15-4",{"v":49,"d":"49.00"},{"v":198.9,"d":"198.90"},{"v":6,"d":"6.00"},24.36,"http://selleckchem.com/products/Sophocarpine.html","C15H22N2O","free base","N/A","O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.394,1,0,0]
["S2406","Chrysophanic Acid","e5","L3000-10","in 10mM DMSO","EGFR,mTOR","Protein Tyrosine Kinase","Chrysophanic Acid (Chrysophanol) a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.",254.24,"481-74-3",{"v":5,"d":"5.00"},19.67,"<1","N/A","http://selleckchem.com/products/Chrysophanic-acid-Chrysophanol.html","C15H10O4","free base","Chrysophanol","CC1=CC2=C(C(=C1)O)C(=O)C3=C(O)C=CC=C3C2=O",{"v":2.81,"d":"2.810"},2,2,0]
["S2407","Curcumol","f5","L3000-10","in 10mM DMSO","JAK","JAK/STAT","Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.",236.35,"4871-97-0",{"v":47,"d":"47.00"},198.86,"<1","N/A","http://selleckchem.com/products/Curcumol.html","C15H24O2","free base","N/A","CC(C)C1CC23OC1(O)CC(=C)C2CCC3C",2.786,1,0,1]
["S2408","Cephalomannine","g5","L3000-10","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","Cephalomannine (Baccatin III) is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice.",{"v":831.9,"d":"831.90"},"71610-00-9",{"v":100,"d":"100.00"},120.21,"<1","N/A","http://selleckchem.com/products/cephalomannine.html","C45H53NO14","free base","Baccatin III","C/C=C(C)/C(=O)NC(C(O)C(=O)OC1CC2(O)C(OC(=O)C3=CC=CC=C3)C4C(C)(C(O)CC5OCC45OC(C)=O)C(=O)C(OC(C)=O)C(=C1C)C2(C)C)C6=CC=CC=C6",2.937,11,3,14]
["S2409","10-Deacetylbaccatin-III","h5","L3000-10","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","10-Deacetylbaccatin-III(10-DB III) is an antineoplastic agent and an anti-cancer intermediate.",544.59,"32981-86-5",{"v":109,"d":"109.00"},200.15,"<1","N/A","http://selleckchem.com/products/10-dab-10-deacetylbaccatin.html","C29H36O10","free base","10-DB III","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(O)C(=C(C(O)C3=O)C5(C)C)C",0.364,6,3,5]
["S2412","Genipin","a6","L3000-10","in 10mM DMSO","Apoptosis related","Apoptosis","Genipin((+)-Genipin) is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.",226.23,"6902-77-8",{"v":45,"d":"45.00"},198.91,"<1","N/A","http://selleckchem.com/products/genipin.html","C11H14O5","free base","(+)-Genipin","COC(=O)C1=COC(O)C2C1CC=C2CO",-0.319,3,1,3]
["S2413","Geniposidic acid","b6","L3000-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.",374.34,"27741-01-1",{"v":16,"d":"16.00"},42.74,"<1","N/A","http://selleckchem.com/products/geniposidic-acid.html","C16H22O10","free base","N/A","OCC1OC(OC2OC=C(C3CC=C(CO)C23)C(O)=O)C(O)C(O)C1O",-2.291,4,5,5]
["S2415","Astragaloside A","c6","L3000-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.",784.97,"83207-58-3",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://selleckchem.com/products/astragaloside-a.html","C41H68O14","free base","N/A","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O",-0.348,5,8,7]
["S2422","Ipriflavone (Osteofix)","d6","L3000-10","in 10mM DMSO","Others","Others","Ipriflavone (7-Isopropoxyisoflavon) is used to inhibit bone resorption.",280.32,"35212-22-7",{"v":56,"d":"56.00"},199.77,"<1","N/A","http://selleckchem.com/products/ipriflavone.html","C18H16O3","free base","N/A","CC(C)OC1=CC=C2C(=C1)OC=C(C2=O)C3=CC=CC=C3",3.576,3,0,3]
["S2423","(S)-10-Hydroxycamptothecin","e6","L3000-10","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.",364.35,"19685-09-7",{"v":8,"d":"8.00"},21.96,"<1","N/A","http://selleckchem.com/products/10-hydroxycamptothecin.html","C20H16N2O5","free base","10-HCPT","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=CC(=CC=C5N=C34)O)C2=O",1.504,4,1,1]
["S2425","Apocynin (NSC 2146)","f6","L3000-10","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.",166.17,"498-02-2",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/apocynin-acetovanillone.html","C9H10O3","free base","Acetovanillone, NSC 209524","COC1=C(O)C=CC(=C1)C(C)=O",1.311,2,1,2]
["S2438","Synephrine HCl","g6","L3000-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.",203.67,"5985-28-4",{"v":14,"d":"14.00"},68.74,{"v":41,"d":"41.00"},201.31,"http://selleckchem.com/products/synephrine-hcl.html","C9H13NO2.HCl","Hydrochloride","N/A","Cl.CNCC(O)C1=CC=C(O)C=C1",0.997,0,3,3]
["S2439","Guanosine","h6","L3000-10","in 10mM DMSO","Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.",283.24,"118-00-3",{"v":56,"d":"56.00"},197.71,"<1","N/A","http://selleckchem.com/products/guanosine.html","C10H13N5O5","free base","N/A","NC1=NC2=C(N=C[N]2C3OC(CO)C(O)C3O)C(=O)N1",{"v":-2.38,"d":"-2.380"},4,5,2]
["S2443","Tolbutamide (HLS 831)","a7","L3000-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.",270.35,"64-77-7",{"v":54,"d":"54.00"},199.74,"<1","N/A","http://selleckchem.com/products/tolbutamide.html","C12H18N2O3S","free base","HLS 831","CCCCNC(=O)N[S](=O)(=O)C1=CC=C(C)C=C1",2.336,3,2,5]
["S2448","Gambogic Acid","b7","L3000-10","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.",628.75,"2752-65-0",{"v":100,"d":"100.00"},159.05,"<1","N/A","http://selleckchem.com/products/gambogic-acid.html","C38H44O8","free base","Guttatic Acid, Guttic Acid, Beta-Guttiferrin","CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(=C2C=C1)O)C(=O)C4=CC5CC6C(C)(C)OC(C\\C=C(C)/C(O)=O)(C5=O)C46O3",6.957,6,1,8]
["S2449","Colforsin","c7","L3000-10","in 10mM DMSO","Autophagy,cAMP,FXR","GPCR & G Protein","Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.",{"v":410.5,"d":"410.50"},"66575-29-9",{"v":82,"d":"82.00"},199.76,"<1","N/A","http://selleckchem.com/products/forskolin.html","C22H34O7","free base","Forskolin, HL 362, Coleonol","CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C3(O)C(=O)CC(C)(OC13C)C=C",0.837,4,2,3]
["S2450","Equol","d7","L3000-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.",242.27,"531-95-3",{"v":48,"d":"48.00"},198.13,"<1","N/A","http://selleckchem.com/products/equol.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=CC(=CC=C3C2)O",3.211,1,2,1]
["S2455","Bethanechol chloride","e7","L3000-10","in 10mM DMSO","AChR","Neuronal Signaling","Bethanechol chloride(Myocholine,Urecholine) is a selective muscarinic receptor agonist without any effect on nicotinic receptors.",196.68,"590-63-6",{"v":39,"d":"39.00"},198.29,{"v":39,"d":"39.00"},198.29,"http://selleckchem.com/products/Carbamyl-beta-methylcholine-chloride(Bethanechol-chloride).html","C7H17N2O2.Cl","quaternary-N Chloride salt","Myocholine,Urecholine","[Cl-].CC(C[N+](C)(C)C)OC(N)=O",-3.702,2,1,4]
["S2456","Chlorpromazine HCl","f7","L3000-10","in 10mM DMSO","Dopamine Receptor,Potassium Channel","Neuronal Signaling","Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.",355.33,"69-09-0",{"v":71,"d":"71.00"},199.81,{"v":71,"d":"71.00"},199.81,"http://selleckchem.com/products/Chlorpromazine-hydrochloride(Sonazine).html","C17H19ClN2S.HCl","Hydrochloride","Sonazine","Cl.CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",5.121,0,0,4]
["S2458","Clonidine HCl","g7","L3000-10","in 10mM DMSO","Adrenergic Receptor,Autophagy","Neuronal Signaling","Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.",{"v":266.5,"d":"266.50"},"4205-91-8",{"v":53,"d":"53.00"},198.87,{"v":53,"d":"53.00"},198.87,"http://selleckchem.com/products/Clonidine-hydrochloride(Catapres).html","C9H9Cl2N3.HCl","Hydrochloride","Kapvay","Cl.ClC1=C(NC2=NCCN2)C(=CC=C1)Cl",2.736,1,2,2]
["S2461","Domperidone","h7","L3000-10","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.",425.91,"57808-66-9",{"v":48,"d":"48.00"},{"v":112.7,"d":"112.70"},"<1","N/A","http://selleckchem.com/products/Domperidone(Motilium).html","C22H24ClN5O2","free base","N/A","ClC1=CC2=C(C=C1)N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)N2",2.453,2,2,5]
["S2466","Estriol","a8","L3000-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estriol (NSC-12169) is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.",288.39,"50-27-1",{"v":57,"d":"57.00"},197.65,"<1","N/A","http://selleckchem.com/products/Estriol(Oestriol).html","C18H24O3","free base","NSC-12169","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CC(O)C2O",2.871,0,3,0]
["S2467","Famciclovir","b8","L3000-10","in 10mM DMSO","Antiviral","Microbiology","Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.",321.34,"104227-87-4",{"v":64,"d":"64.00"},199.17,{"v":64,"d":"64.00"},199.17,"http://selleckchem.com/products/Famciclovir(Famvir).html","C14H19N5O4","free base","BRL-42810","CC(=O)OCC(CC[N]1C=NC2=CN=C(N)N=C12)COC(C)=O",-0.294,7,1,9]
["S2468","Fenbendazole","c8","L3000-10","in 10mM DMSO","Parasite","Microbiology","Fenbendazole(Fenbendazol,Phenbendasol) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/mL.",299.35,"43210-67-9",{"v":4,"d":"4.00"},13.36,"<1","N/A","http://selleckchem.com/products/Fenbendazole(Panacur).html","C15H13N3O2S","free base","Fenbendazol,Phenbendasol","COC(=O)NC1=NC2=C([NH]1)C=C(SC3=CC=CC=C3)C=C2",3.769,3,2,4]
["S2470","Fluocinolone Acetonide","d8","L3000-10","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.",{"v":452.5,"d":"452.50"},"67-73-2",{"v":90,"d":"90.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Fluocinolone-acetonide(Flucort-N).html","C24H30F2O6","free base","Flucort-N","CC1(C)OC2CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CO",0.995,4,2,2]
["S2471","Gallamine Triethiodide","e8","L3000-10","in 10mM DMSO","AChR","Neuronal Signaling","Gallamine Triethiodide  is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.",891.53,"65-29-2",{"v":100,"d":"100.00"},112.17,{"v":100,"d":"100.00"},112.17,"http://selleckchem.com/products/Gallamine-triethiodide(Flaxedil).html","C30H60I3N3O3","tri-quaternary-N iodide salt","N/A","[I-].[I-].[I-].CC[N+](CC)(CC)CCOC1=C(OCC[N+](CC)(CC)CC)C(=CC=C1)OCC[N+](CC)(CC)CC",-8.065,3,0,21]
["S2473","Hexestrol","f8","L3000-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.",270.37,"84-16-2",{"v":42,"d":"42.00"},155.34,"<1","N/A","http://selleckchem.com/products/Hexestrol(Bibenzyl).html","C18H22O2","free base","Bibenzyl","CCC(C(CC)C1=CC=C(O)C=C1)C2=CC=C(O)C=C2",5.192,0,2,5]
["S2475","Imatinib (STI571)","g8","L3000-10","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571,Gleevec, Glivec, CGP057148B) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.",{"v":493.6,"d":"493.60"},"152459-95-5",{"v":33,"d":"33.00"},66.86,"<1","N/A","http://selleckchem.com/products/Imatinib(STI571).html","C29H31N7O","free base","STI571,Gleevec, Glivec, CGP057148B","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",{"v":4.22,"d":"4.220"},4,2,7]
["S2480","Loperamide HCl","h8","L3000-10","in 10mM DMSO","Autophagy,Opioid Receptor","Neuronal Signaling","Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.",{"v":513.5,"d":"513.50"},"34552-83-5",{"v":22,"d":"22.00"},42.84,"<1","N/A","http://selleckchem.com/products/Loperamide-hydrochloride.html","C29H33ClN2O2.HCl","Hydrochloride","ADL 2-1294,R-18553 hydrochloride","Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.017,1,0,7]
["S2481","Manidipine","a9","L3000-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.",{"v":610.7,"d":"610.70"},"89226-50-6",{"v":122,"d":"122.00"},199.77,"<1","N/A","http://selleckchem.com/products/Manidipine(Manyper).html","C35H38N4O6","free base","CV-4093,(±)-Manidipine","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.058,4,1,12]
["S2484","Milrinone","b9","L3000-10","in 10mM DMSO","PDE","Metabolism","Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.",211.22,"78415-72-2",{"v":42,"d":"42.00"},198.84,"<1","N/A","http://selleckchem.com/products/Milrinone(Primacor).html","C12H9N3O","free base","Win 47203,Primacor","CC1=C(C=C(C#N)C(=O)N1)C2=CC=NC=C2",0.356,2,1,1]
["S2485","Mitoxantrone (NSC-301739) 2HCl","c9","L3000-10","in 10mM DMSO","Apoptosis related,COVID-19,PKC,Topoisomerase","DNA Damage/DNA Repair","Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.",{"v":517.4,"d":"517.40"},"70476-82-3",{"v":89,"d":"89.00"},172.01,{"v":89,"d":"89.00"},172.01,"http://selleckchem.com/products/Mitoxantrone-Hydrochloride.html","C22H29ClN4O6.2HCl","Dihydrochloride","NSC-301739 2HCl","Cl.Cl.OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C3=C(O)C=CC(=C3C2=O)O",0.832,2,8,12]
["S2486","Moroxydine HCl","d9","L3000-10","in 10mM DMSO","Antiviral","Microbiology","Moroxydine HCl(ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.",207.66,"3160-91-6",{"v":42,"d":"42.00"},202.25,{"v":42,"d":"42.00"},202.25,"http://selleckchem.com/products/Moroxydine-hydrochloride.html","C6H13N5O.HCl","Hydrochloride","ABOB hydrochloride","Cl.NC(=N)NC(=N)N1CCOCC1",-0.672,1,2,3]
["S2487","Mycophenolic acid","e9","L3000-10","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dehydrogenase,Selection Antibiotics for Transfected Cell","Metabolism","Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.",320.34,"24280-93-1",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/Mycophenolic-acid(Mycophenolate).html","C17H20O6","free base","Mycophenolate, RS-61443","COC1=C(C)C2=C(C(=C1C\\C=C(/C)CCC(O)=O)O)C(=O)OC2",3.157,4,1,6]
["S2489","Nateglinide","f9","L3000-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Nateglinide (Starlix,A-4166,SDZ DJN 608) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.",317.42,"105816-04-4",{"v":63,"d":"63.00"},198.48,"<1","N/A","http://selleckchem.com/products/Nateglinide(Starlix).html","C19H27NO3","free base","Starlix,A-4166,SDZ DJN 608","CC(C)C1CCC(CC1)C(=O)NC(CC2=CC=CC=C2)C(O)=O",3.981,2,1,6]
["S2492","Novobiocin Sodium (NSC 2382)","g9","L3000-10","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.",634.61,"1476-53-5",{"v":100,"d":"100.00"},157.58,{"v":100,"d":"100.00"},157.58,"http://selleckchem.com/products/Novobiocin-sodium(Albamycin).html","C31H35N2O11.Na","Sodium Salt","Albamycin,Cathomycin,NSC 2382","[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=C(NC(=O)C4=CC=C([O-])C(=C4)CC=C(C)C)C(=O)OC3=C2C)O)OC1(C)C",2.747,8,4,9]
["S2493","Olanzapine","h9","L3000-10","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.",312.44,"132539-06-1",{"v":62,"d":"62.00"},198.44,"<1","N/A","http://selleckchem.com/products/Olanzapine(Zyprexa).html","C17H20N4S","free base","LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera","CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3",{"v":2.69,"d":"2.690"},1,1,1]
["S2494","Olopatadine HCl","a10","L3000-10","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Olopatadine HCl(ALO4943A,KW4679) is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine.",373.87,"140462-76-6",{"v":75,"d":"75.00"},{"v":200.6,"d":"200.60"},{"v":13,"d":"13.00"},34.77,"http://selleckchem.com/products/Olopatadine-hydrochloride(Opatanol).html","C21H23NO3.HCl","Hydrochloride","ALO4943A,KW4679","Cl.CN(C)CC\\C=C/1C2=C(COC3=C1C=C(CC(O)=O)C=C3)C=CC=C2",{"v":0.92,"d":"0.920"},2,0,5]
["S2496","Ozagrel","b10","L3000-10","in 10mM DMSO","P450 (e.g. CYP17),Prostaglandin Receptor","GPCR & G Protein","Ozagrel (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.",228.25,"82571-53-7",{"v":46,"d":"46.00"},201.53,"<1","N/A","http://selleckchem.com/products/Ozagrel.html","C13H12N2O2","free base","OKY-046","OC(=O)/C=C/C1=CC=C(C[N]2C=CN=C2)C=C1",1.604,2,0,4]
["S2497","Pancuronium dibromide","c10","L3000-10","in 10mM DMSO","AChR","Neuronal Signaling","Pancuronium dibromide(Pavulon) is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.",732.67,"15500-66-0",{"v":100,"d":"100.00"},136.49,{"v":100,"d":"100.00"},136.49,"http://selleckchem.com/products/Pancuronium-bromide(Pavulon).html","C35H60N2O4.2Br","di-quaternary-N bromide salt","Pavulon","[Br-].[Br-].CC(=O)OC1CC2CCC3C(CCC4(C)C3CC(C4OC(C)=O)[N+]5(C)CCCCC5)C2(C)CC1[N+]6(C)CCCCC6",-2.043,4,0,6]
["S2499","Phenoxybenzamine HCl","d10","L3000-10","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.",{"v":340.3,"d":"340.30"},"63-92-3",{"v":68,"d":"68.00"},199.82,{"v":17,"d":"17.00"},49.96,"http://selleckchem.com/products/Phenoxybenzamine-hydrochloride.html","C18H22ClNO.HCl","HCl","NSC 37448, NCI-c01661","Cl.CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2",{"v":4.96,"d":"4.960"},1,0,8]
["S2502","Quinine HCl Dihydrate","e10","L3000-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.",396.91,"6119-47-7",{"v":79,"d":"79.00"},199.04,{"v":43,"d":"43.00"},108.34,"http://selleckchem.com/products/Quinine-hydrochloride-dihydrate.html","C20H24N2O2.HCl.2H2O","Hydrochloride dihydrate","N/A","O.O.Cl.COC1=CC2=C(C=C1)N=CC=C2C(O)C3CC4CCN3CC4C=C",2.701,2,1,4]
["S2503","Racecadotril","f10","L3000-10","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Racecadotril (Acetorphan) is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM.",385.48,"81110-73-8",{"v":22,"d":"22.00"},57.07,"<1","N/A","http://selleckchem.com/products/Racecadotril(Acetorphan).html","C21H23NO4S","free base","Acetorphan","CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2",3.128,4,1,11]
["S2504","Ribavirin (ICN-1229)","g10","L3000-10","in 10mM DMSO","Antiviral","Microbiology","Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.",244.21,"36791-04-5",{"v":49,"d":"49.00"},200.65,{"v":49,"d":"49.00"},200.65,"http://selleckchem.com/products/Ribavirin(Copegus).html","C8H12N4O5","free base","NSC-163039, RTCA, Tribavirin","NC(=O)C1=N[N](C=N1)C2OC(CO)C(O)C2O",-2.745,4,4,3]
["S2505","Rosiglitazone (BRL-49653) maleate","h10","L3000-10","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",{"v":473.5,"d":"473.50"},"155141-29-0",{"v":94,"d":"94.00"},198.52,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-maleate.html","C18H19N3O3S.C4H4O4","Maleate","BRL-49653C","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=NC=CC=C3.OC(=O)\\C=C/C(O)=O",3.307,6,1,9]
["S2508","Scopolamine (LSM-4015) HBr","a11","L3000-10","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.",384.26,"114-49-8",{"v":76,"d":"76.00"},197.78,{"v":76,"d":"76.00"},197.78,"http://selleckchem.com/products/Scopolamine-hydrobromide.html","C17H21NO4.HBr","Hydrobromide","LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide","Br.CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",1.314,3,1,5]
["S2509","Sotalol HCl","b11","L3000-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Sotalol(MJ-1999)  is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.",308.82,"959-24-0",{"v":61,"d":"61.00"},197.53,{"v":61,"d":"61.00"},197.53,"http://selleckchem.com/products/Sotalol-hydrochloride(Betapace).html","C12H20N2O3S.HCl","Hydrochloride","MJ-1999","Cl.CC(C)NCC(O)C1=CC=C(N[S](C)(=O)=O)C=C1",0.876,2,3,6]
["S2511","Sulfadoxine","c11","L3000-10","in 10mM DMSO","Anti-infection","Microbiology","Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.",310.33,"2447-57-6",{"v":62,"d":"62.00"},199.78,"<1","N/A","http://selleckchem.com/products/Sulfadoxine(Sulphadoxine).html","C12H14N4O4S","free base","Sulphadoxine","COC1=C(OC)C(=NC=N1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.837,6,2,5]
["S2512","Tenoxicam","d11","L3000-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.",337.38,"59804-37-4",{"v":68,"d":"68.00"},201.55,"<1","N/A","http://selleckchem.com/products/Tenoxicam(Mobiflex).html","C13H11N3O4S2","free base","Ro-12-0068","CN1C(=C(O)C2=C(C=CS2)[S]1(=O)=O)C(=O)NC3=CC=CC=N3",0.454,4,2,2]
["S2515","Vardenafil HCl Trihydrate","e11","L3000-10","in 10mM DMSO","PDE","Metabolism","Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.",579.11,"330808-88-3",{"v":100,"d":"100.00"},172.68,{"v":10,"d":"10.00"},17.27,"http://selleckchem.com/products/Vardenafil(Vivanza).html","C23H32N6O4S.HCl.3H2O","Hydrochloride trihydrate","BAY38-9456","O.O.O.Cl.CCCC1=NC(=C2[N]1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(CC)CC4)C",2.109,6,1,8]
["S2516","Xylazine HCl","f11","L3000-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.",256.79,"23076-35-9",{"v":50,"d":"50.00"},194.71,{"v":12,"d":"12.00"},46.73,"http://selleckchem.com/products/Xylazine(Rompun).html","C12H16N2S.HCl","Hydrochloride","BAY 1470 hydrochloride","Cl.CC1=C(NC2=NCCCS2)C(=CC=C1)C",3.647,1,1,2]
["S2517","Maprotiline HCl","g11","L3000-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.",313.86,"10347-81-6",{"v":63,"d":"63.00"},200.73,"<1","N/A","http://selleckchem.com/products/Maprotiline-hydrochloride.html","C20H23N.HCl","Hydrochloride","N/A","Cl.CNCCCC12CCC(C3=CC=CC=C13)C4=C2C=CC=C4",4.498,0,1,4]
["S2519","Naphazoline HCl","h11","L3000-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.",246.74,"550-99-2",{"v":17,"d":"17.00"},{"v":68.9,"d":"68.90"},{"v":49,"d":"49.00"},198.59,"http://selleckchem.com/products/Naphazoline-hydrochloride-Naphcon.html","C14H14N2.HCl","Hydrochloride","N/A","Cl.C1CN=C(CC2=C3C=CC=CC3=CC=C2)N1",2.442,1,1,2]
["S2526","Alizarin","a2","L3000-11","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.",240.21,"72-48-0",{"v":48,"d":"48.00"},199.83,"<1","N/A","http://selleckchem.com/products/Alizarin.html","C14H8O4","free base","Anthraquinonic","OC1=C(O)C2=C(C=C1)C(=O)C3=CC=CC=C3C2=O",2.324,2,2,0]
["S2528","Ciclopirox","b2","L3000-11","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator.",207.27,"29342-05-0",{"v":42,"d":"42.00"},202.63,"<1","N/A","http://selleckchem.com/products/Ciclopirox-Penlac.html","C12H17NO2","Free Base","HOE 296b, Penlac","CC1=CC(=O)N(O)C(=C1)C2CCCCC2",2.489,1,0,1]
["S2529","Dopamine HCl","c2","L3000-11","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Dopamine HCl(ASL279, NSC 173182) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.",189.64,"62-31-7",{"v":38,"d":"38.00"},200.38,{"v":38,"d":"38.00"},200.38,"http://selleckchem.com/products/Dopamine-hydrochloride-Inotropin.html","C8H11NO2.HCl","Hydrochloride","ASL279, NSC 173182","Cl.NCCC1=CC(=C(O)C=C1)O",1.155,0,3,2]
["S2532","L-Ascorbyl 6-palmitate","d2","L3000-11","in 10mM DMSO","N/A","Others","Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.",414.53,"137-66-6",{"v":83,"d":"83.00"},200.23,"<1","N/A","http://selleckchem.com/products/L-Ascorbyl-6-palmitate.html","C22H38O7","free base","N/A","CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(=C1O)O",5.268,4,3,18]
["S2533","Ritodrine HCl","e2","L3000-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.",323.81,"23239-51-2",{"v":65,"d":"65.00"},200.73,{"v":65,"d":"65.00"},200.73,"http://selleckchem.com/products/Ritodrine-hydrochloride-Yutopar.html","C17H21NO3.HCl","Hydrochloride","NSC 291565,DU 21220, Ritodrine","Cl.CC(NCCC1=CC=C(O)C=C1)C(O)C2=CC=C(O)C=C2",3.037,0,4,6]
["S2535","Econazole nitrate","f2","L3000-11","in 10mM DMSO","Calcium Channel,Fungal","Transmembrane Transporters","Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.",{"v":444.7,"d":"444.70"},"24169-02-6",{"v":89,"d":"89.00"},200.13,"<1","N/A","http://selleckchem.com/products/Econazole-nitrate-Spectazole.html","C18H15Cl3N2O.HNO3","Nitrate","NSC 243115,Spectazole","O[N+]([O-])=O.ClC1=CC=C(COC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C=C1",3.722,2,0,6]
["S2536","Miconazole","g2","L3000-11","in 10mM DMSO","Fungal","Microbiology","Miconazole (Monistat,R18134) is an imidazole antifungal agent.",416.13,"22916-47-8",{"v":83,"d":"83.00"},199.46,"<1","N/A","http://selleckchem.com/products/Miconazole-Monistat.html","C18H14Cl4N2O","Free Base","Monistat,R18134","ClC1=CC=C(COC(C[N]2C=CN=C2)C3=C(Cl)C=C(Cl)C=C3)C(=C1)Cl",5.645,2,0,6]
["S2537","Secnidazole","h2","L3000-11","in 10mM DMSO","Anti-infection","Microbiology","Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.",185.18,"3366-95-8",{"v":37,"d":"37.00"},199.81,{"v":37,"d":"37.00"},199.81,"http://selleckchem.com/products/Secnidazole-Flagentyl.html","C7H11N3O3","free base","PM 185184, RP 14539","CC(O)C[N]1C(=NC=C1[N+]([O-])=O)C",{"v":0.04,"d":"0.040"},1,1,3]
["S2541","Clomipramine HCl","a3","L3000-11","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Clomipramine HCl(Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.",351.31,"17321-77-6",{"v":70,"d":"70.00"},199.25,{"v":70,"d":"70.00"},199.25,"http://selleckchem.com/products/Clomipramine-hydrochloride-Anafranil.html","C19H23ClN2.HCl","Hydrochloride","Anafranil","Cl.CN(C)CCCN1C2=C(CCC3=C1C=C(Cl)C=C3)C=CC=C2",5.434,0,0,4]
["S2543","Ceftiofur HCl","b3","L3000-11","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Ceftiofur HCl (U-67279A,Excenel hydrochloride) is a cephalosporin antibiotic, used to treat both Gram-positive and Gram-negative bacteria infection.",560.02,"103980-44-5",{"v":100,"d":"100.00"},178.57,"<1","N/A","http://selleckchem.com/products/Ceftiofur-hydrochloride.html","C19H17N5O7S3.HCl","Hydrochloride","U-67279A,Excenel hydrochloride","Cl.CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)CSC(=O)C3=CC=CO3)C4=CSC(=N4)N",{"v":1.09,"d":"1.090"},8,2,9]
["S2545","Scopine","c3","L3000-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Scopine(6,7-Epoxytropine) is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.",155.19,"498-45-3",{"v":31,"d":"31.00"},199.76,"<1","N/A","http://selleckchem.com/products/scopine.html","C8H13NO2","free base","6,7-Epoxytropine","CN1C2CC(O)CC1C3OC23",-0.627,1,1,0]
["S2549","Trospium chloride","d3","L3000-11","in 10mM DMSO","AChR","Neuronal Signaling","Trospium chloride  is a competitive muscarinic cholinergic receptor antagonist.",427.96,"10405-02-4",{"v":41,"d":"41.00"},{"v":95.8,"d":"95.80"},{"v":86,"d":"86.00"},200.95,"http://selleckchem.com/products/Trospium-chloride-Sanctura.html","C25H30NO3.Cl","quaternary-N chloride salt","N/A","[Cl-].OC(C(=O)OC1CC2CCC(C1)[N+]23CCCC3)(C4=CC=CC=C4)C5=CC=CC=C5",-0.324,2,0,5]
["S2552","Azelastine HCl","e3","L3000-11","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.",418.36,"79307-93-0",{"v":28,"d":"28.00"},66.93,{"v":35,"d":"35.00"},83.66,"http://selleckchem.com/products/azelastine.html","C22H24ClN3O.HCl","Hydrochloride","N/A","Cl.CN1CCCC(CC1)N2N=C(CC3=CC=C(Cl)C=C3)C4=CC=CC=C4C2=O",4.476,2,0,3]
["S2553","5-Aminolevulinic acid HCl","f3","L3000-11","in 10mM DMSO","Others","Others","5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.",167.59,"5451-09-2",{"v":34,"d":"34.00"},202.88,{"v":34,"d":"34.00"},202.88,"http://selleckchem.com/products/5-Aminolevulinic-acid-hydrochloride.html","C5H9NO3.HCl","Hydrochloride","5-ALA hydrochloride","Cl.NCC(=O)CCC(O)=O",-3.318,2,1,4]
["S2554","Daphnetin","g3","L3000-11","in 10mM DMSO","EGFR,PKA,PKC","Angiogenesis","Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.",178.14,"486-35-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/Daphnetin.html","C9H6O4","free base","N/A","OC1=CC=C2C=CC(=O)OC2=C1O",1.415,2,2,0]
["S2555","Clarithromycin","h3","L3000-11","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.",747.95,"81103-11-9",{"v":25,"d":"25.00"},33.42,"<1","N/A","http://selleckchem.com/products/clarithromycin.html","C38H69NO13","free base","A-56268","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(CC(C)C(=O)C(C)C(O)C1(C)O)OC",{"v":2.2,"d":"2.200"},9,3,8]
["S2556","Rosiglitazone (BRL 49653)","a4","L3000-11","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",357.43,"122320-73-4",{"v":71,"d":"71.00"},198.64,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-Avandia.html","C18H19N3O3S","Free Base","BRL 49653","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",3.268,4,1,7]
["S2559","Cortisone acetate","b4","L3000-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.",402.48,"50-04-4",{"v":7,"d":"7.00"},17.39,"<1","N/A","http://selleckchem.com/products/Cortisone-acetate-Cortone.html","C23H30O6","free base","Cortone,NSC 49420","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(=O)CC12C",1.619,5,0,4]
["S2561","Clomifene citrate","c4","L3000-11","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Clomifene citrate (NSC 35770, Clomiphene citrate) is a selective estrogen receptor modulator, used in the treatment of ovulation induction.",598.08,"50-41-9",{"v":120,"d":"120.00"},200.64,"<1","N/A","http://selleckchem.com/products/Clomifene-citrate-Serophene.html","C26H28ClNO.C6H8O7","Citrate","NSC 35770, Clomiphene citrate","CCN(CC)CCOC1=CC=C(C=C1)C(=C(Cl)/C2=CC=CC=C2)/C3=CC=CC=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",2.129,4,0,14]
["S2564","Cloxacillin Sodium","d4","L3000-11","in 10mM DMSO","Anti-infection","Microbiology","Cloxacillin Sodium(Cloxacap,BRL 1621 sodium salt) is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.",475.88,"7081-44-9",{"v":55,"d":"55.00"},115.58,{"v":55,"d":"55.00"},115.58,"http://selleckchem.com/products/Cloxacillin-sodium-Cloxacap.html","C19H19ClN3NaO6S","Sodium Salt & hydrate","Cloxacap,BRL 1621 sodium salt","O.[Na+].CC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C([O-])=O)C(=NO1)C4=CC=CC=C4Cl",0.619,4,1,4]
["S2566","Isoprenaline (NCI-C55630) HCl","e4","L3000-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.",247.72,"51-30-9",{"v":50,"d":"50.00"},201.84,{"v":50,"d":"50.00"},201.84,"http://selleckchem.com/products/Isoprenaline-hydrochloride.html","C11H17NO3.HCl","Hydrochloride","NCI-c55630,Isoproterenol hydrochloride","Cl.CC(C)NCC(O)C1=CC=C(O)C(=C1)O",1.481,0,4,4]
["S2567","Medroxyprogesterone acetate (NSC-26386)","f4","L3000-11","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Medroxyprogesterone acetate (MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.",386.52,"71-58-9",{"v":12,"d":"12.00"},31.05,"<1","N/A","http://selleckchem.com/products/Medroxyprogesterone-acetate.html","C24H34O4","Free Base","MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin","CC1CC2C(CCC3(C)C2CCC3(OC(C)=O)C(C)=O)C4(C)CCC(=O)C=C14",3.755,4,0,3]
["S2569","Phenylephrine (NCI-C55641) HCl","g4","L3000-11","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Phenylephrine HCl (NCI-c55641,Phenylephrine hydrochloride,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride) is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.",203.67,"61-76-7",{"v":41,"d":"41.00"},201.31,{"v":41,"d":"41.00"},201.31,"http://selleckchem.com/products/Phenylephrine-hydrochloride.html","C9H13NO2.HCl","Hydrochloride","NCI-c55641,Phenylephrine hydrochloride,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride","Cl.CNCC(O)C1=CC(=CC=C1)O",0.997,0,3,3]
["S2570","Prednisolone Acetate","h4","L3000-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.",402.48,"52-21-1",{"v":81,"d":"81.00"},201.25,"<1","N/A","http://selleckchem.com/products/Prednisolone-acetate-Omnipred.html","C23H30O6","free base","Omnipred,Prednisolone-21-acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C",1.639,4,1,4]
["S2576","Xylometazoline HCl","a5","L3000-11","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.",280.84,"1218-35-5",{"v":27,"d":"27.00"},96.14,{"v":56,"d":"56.00"},{"v":199.4,"d":"199.40"},"http://selleckchem.com/products/xylometazoline-hcl.html","C16H24N2.HCl","HCl","N/A","Cl.CC1=C(CC2=NCCN2)C(=CC(=C1)C(C)(C)C)C",3.906,1,1,3]
["S2577","Phenacetin","b5","L3000-11","in 10mM DMSO","COX","Neuronal Signaling","Phenacetin (Acetophenetidin) is a non-opioid analgesic without anti-inflammatory properties.",179.22,"62-44-2",{"v":36,"d":"36.00"},200.87,"<1","N/A","http://selleckchem.com/products/phenacetin.html","C10H13NO2","free base","Acetophenetidin","CCOC1=CC=C(NC(C)=O)C=C1",1.282,2,1,3]
["S2579","Zidovudine","c5","L3000-11","in 10mM DMSO","CRISPR/Cas9,Reverse Transcriptase","Microbiology","Zidovudine (ZDV, Azidothymidine, NSC 602670,Retrovir) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.",267.24,"30516-87-1",{"v":53,"d":"53.00"},198.32,{"v":53,"d":"53.00"},198.32,"http://selleckchem.com/products/zidovudine-retrovir.html","C10H13N5O4","free base","Azidothymidine, NSC 602670,Retrovir","CC1=CN(C2CC(N=[N+]=[N-])C(CO)O2)C(=O)NC1=O",0.064,4,2,3]
["S2581","Quinapril HCl","d5","L3000-11","in 10mM DMSO","RAAS","Endocrinology & Hormones","Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.",474.98,"82586-55-8",{"v":18,"d":"18.00"},{"v":37.9,"d":"37.90"},{"v":95,"d":"95.00"},200.01,"http://selleckchem.com/products/quinapril-hydrochloride-accupril.html","C25H30N2O5.HCl","Hydrochloride","CI-906, PD-109452-2","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=C(CC2C(O)=O)C=CC=C3",1.038,4,1,10]
["S2584","Clobetasol propionate","e5","L3000-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.",466.97,"25122-46-7",{"v":93,"d":"93.00"},199.16,"<1","N/A","http://selleckchem.com/products/clobetasol-propionate.html","C25H32ClFO5","free base","CGP9555, CCl 4725","CCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.958,4,1,5]
["S2585","Brompheniramine hydrogen maleate","f5","L3000-11","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Brompheniramine hydrogen maleate(Brompheniramine maleate) is a histamine H1 receptors antagonist.",435.31,"980-71-2",{"v":87,"d":"87.00"},199.86,{"v":46,"d":"46.00"},105.67,"http://selleckchem.com/products/brompheniramine.html","C16H19BrN2.C4H4","Maleate","Brompheniramine maleate","CN(C)CCC(C1=CC=C(Br)C=C1)C2=CC=CC=N2.OC(=O)\\C=C/C(O)=O",0.784,3,0,7]
["S2586","Dimethyl Fumarate","g5","L3000-11","in 10mM DMSO","Nrf2","Immunology & Inflammation","Dimethyl fumarate (DMF,Tecfidera,BG-12) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.",144.13,"624-49-7",{"v":29,"d":"29.00"},201.21,"<1","N/A","http://selleckchem.com/products/dimethyl-Fumarate.html","C6H8O4","free base","DMF,Tecfidera,BG-12","COC(=O)\\C=C\\C(=O)OC",{"v":0.49,"d":"0.490"},4,0,4]
["S2590","Pioglitazone (AD-4833)","h5","L3000-11","in 10mM DMSO","PPAR","Metabolism","Pioglitazone (AD-4833, U 72107) is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ.",356.44,"111025-46-8",{"v":10,"d":"10.00"},28.06,"<1","N/A","https://www.selleckchem.com/products/pioglitazone.html","C19H20N2O3S","Free Base","U 72107","CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",3.907,4,1,7]
["S2593","Tolvaptan","a6","L3000-11","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Tolvaptan (OPC-41061) is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM, used to treat hyponatremia.",448.94,"150683-30-0",{"v":89,"d":"89.00"},198.24,"<1","N/A","http://selleckchem.com/products/tolvaptan-opc-41061.html","C26H25ClN2O3","free base","OPC-41061","CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(O)C4=C3C=CC(=C4)Cl)C",5.127,2,2,3]
["S2601","Gliclazide","b6","L3000-11","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Gliclazide(S1702, SE1702)  is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.",323.41,"21187-98-4",{"v":65,"d":"65.00"},200.98,"<1","N/A","http://selleckchem.com/products/gliclazide-diamicron.html","C15H21N3O3S","free base","S1702, SE1702","CC1=CC=C(C=C1)[S](=O)(=O)NC(=O)NN2CC3CCCC3C2",1.905,3,2,3]
["S2602","Acemetacin","c6","L3000-11","in 10mM DMSO","COX","Neuronal Signaling","Acemetacin (K-708,TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.",415.82,"53164-05-9",{"v":83,"d":"83.00"},199.61,"<1","N/A","http://selleckchem.com/products/acemetacin-emflex.html","C21H18ClNO6","free base","K-708,TVX 1322","COC1=CC2=C(C=C1)[N](C(=C2CC(=O)OCC(O)=O)C)C(=O)C3=CC=C(Cl)C=C3",3.942,5,0,7]
["S2603","Tioxolone","d6","L3000-11","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.",168.17,"4991-65-5",{"v":34,"d":"34.00"},202.18,"<1","N/A","http://selleckchem.com/products/tioxolone.html","C7H4O3S","free base","Thioxolone","OC1=CC=C2SC(=O)OC2=C1",2.303,2,1,0]
["S2606","Mifepristone (RU486)","e6","L3000-11","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.",429.59,"84371-65-3",{"v":85,"d":"85.00"},197.86,"<1","N/A","http://selleckchem.com/products/Mifepristone(Mifeprex).html","C29H35NO2","free base","RU486, C-1073, RU 38486, RU-486, Mifegyne","CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)C5=CC=C(C=C5)N(C)C",5.655,1,0,3]
["S2607","Buflomedil HCl","f6","L3000-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Buflomedil HCl(NSC 759291) is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease;  A nonselective alpha adrenergic receptor inhibitor.",343.85,"35543-24-9",{"v":31,"d":"31.00"},90.16,{"v":69,"d":"69.00"},200.67,"http://selleckchem.com/products/auflomedil-hcl.html","C17H25NO4.HCl","Hydrochloride","NSC 759291","Cl.COC1=CC(=C(C(=O)CCCN2CCCC2)C(=C1)OC)OC",2.939,4,0,8]
["S2610","Lonidamine (AF-1890)","g6","L3000-11","in 10mM DMSO","Carbohydrate Metabolism,Others","Metabolism","Lonidamine (AF 1890, Diclondazolic Acid, DICA) is an orally administered small molecule hexokinase inactivator.",321.16,"50264-69-2",{"v":64,"d":"64.00"},199.28,"<1","N/A","http://selleckchem.com/products/lonidamine.html","C15H10Cl2N2O2","free base","Diclondazolic Acid, DICA","OC(=O)C1=N[N](CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C13",{"v":4.65,"d":"4.650"},2,0,3]
["S2611","Ethisterone","h6","L3000-11","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ethisterone(17α-Ethynyltestosterone) is a progestogen hormone being considered to treat prostate cancer.",312.45,"434-03-7",{"v":4,"d":"4.00"},{"v":12.8,"d":"12.80"},"<1","N/A","http://www.selleck.cn/products/ethisterone.html","C21H28O2","Free Base","17α-Ethynyltestosterone","CC12CCC(=O)C=C1CCC3C2CCC4(C)C3CCC4(O)C#C",4.521,1,0,0]
["S2615","Noradrenaline bitartrate monohydrate","a7","L3000-11","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.",337.28,"108341-18-0",{"v":64,"d":"64.00"},189.75,{"v":64,"d":"64.00"},189.75,"http://selleckchem.com/products/noradrenaline-bitartrate-monohydrate-levophed.html","C8H11NO3.C4H6O6.H2O","bitartrate monohydrate","Levophed","O.NCC(O)C1=CC(=C(O)C=C1)O.OC(C(O)C(O)=O)C(O)=O",-4.409,2,6,5]
["S2617","TAK-733","b7","L3000-11","in 10mM DMSO","MEK","MAPK","TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.",504.23,"1035555-63-5",{"v":101,"d":"101.00"},200.31,"<1","N/A","http://selleckchem.com/products/tak-733.html","C17H15F2IN4O4","free base","N/A","CN1C(=O)C(=C(NC2=CC=C(I)C=C2F)C3=C1N=CN(CC(O)CO)C3=O)F",0.383,3,3,5]
["S2619","MG132","c7","L3000-11","in 10mM DMSO","Proteasome","Proteases","MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor.  MG132 also inhibits calpain (IC50=1.2 μM).",475.62,"1211877-36-9",{"v":90,"d":"90.00"},189.23,"<1","N/A","http://selleckchem.com/products/MG132.html","C26H41N3O5","free base","(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al","CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",4.371,5,3,15]
["S2621","AZD5438","d7","L3000-11","in 10mM DMSO","CDK","Cell Cycle","AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β.",371.46,"602306-29-6",{"v":74,"d":"74.00"},199.21,"<1","N/A","http://selleckchem.com/products/AZD5438.html","C18H21N5O2S","free base","N/A","CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)[S](C)(=O)=O)C",2.966,5,1,5]
["S2622","PP121","e7","L3000-11","in 10mM DMSO","Bcr-Abl,DNA-PK,mTOR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.",319.36,"1092788-83-4",{"v":64,"d":"64.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/PP121.html","C17H17N7","free base","N/A","NC1=NC=NC2=C1C(=N[N]2C3CCCC3)C4=CN=C5[NH]C=CC5=C4",2.583,4,2,2]
["S2623","Omecamtiv mecarbil (CK-1827452)","f7","L3000-11","in 10mM DMSO","ATPase","Transmembrane Transporters","Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.",401.43,"873697-71-3",{"v":80,"d":"80.00"},199.29,"<1","N/A","http://selleckchem.com/products/Omecamtiv-mecarbil-CK-1827452.html","C20H24FN5O3","free base","N/A","COC(=O)N1CCN(CC1)CC2=CC=CC(=C2F)NC(=O)NC3=CN=C(C)C=C3",1.794,4,2,5]
["S2624","OSI-027","g7","L3000-11","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1","N/A","http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2625","Fostamatinib (R788)","h7","L3000-11","in 10mM DMSO","Syk","Angiogenesis","Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.",580.46,"901119-35-5",{"v":116,"d":"116.00"},199.84,"<1","N/A","http://selleckchem.com/products/R7935788-Fostamatinib.html","C23H26FN6O9P","free base","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC=C(F)C(=N2)NC3=CC=C4OC(C)(C)C(=O)N(CO[P](O)(O)=O)C4=N3)OC",3.458,9,2,10]
["S2626","Rabusertib (LY2603618)","a8","L3000-11","in 10mM DMSO","Apoptosis related,Autophagy,Chk","Cell Cycle","Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.",{"v":436.3,"d":"436.30"},"911222-45-2",{"v":13,"d":"13.00"},{"v":29.8,"d":"29.80"},"<1","N/A","http://selleckchem.com/products/LY2603618-IC-83.html","C18H22BrN5O3","free base","IC-83","CC1=NC=C(NC(=O)NC2=C(OCC3CNCCO3)C=C(C)C(=C2)Br)N=C1",{"v":1.58,"d":"1.580"},5,3,5]
["S2627","Tubastatin A HCl","b8","L3000-11","in 10mM DMSO","HDAC","Epigenetics","Tubastatin A HCl (TSA) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).",371.86,"1310693-92-5",{"v":74,"d":"74.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/tubastatin-a-hcl.html","C20H21N3O2.HCl","Hydrochloride","TSA HCl","Cl.CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=C(C=C4)C(=O)NO",3.463,1,1,3]
["S2630","GW3965 HCl","c8","L3000-11","in 10mM DMSO","Liver X Receptor","Metabolism","GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.",618.51,"405911-17-3",{"v":16,"d":"16.00"},25.87,"<1","N/A","http://selleckchem.com/products/gw3965.html","C33H31ClF3NO3.HCl","hydrochloride","N/A","Cl.OC(=O)CC1=CC=CC(=C1)OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F",5.473,2,0,14]
["S2634","Rebastinib (DCC-2036)","d8","L3000-11","in 10mM DMSO","Bcr-Abl","Angiogenesis","Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.",553.59,"1020172-07-9",{"v":111,"d":"111.00"},200.51,"<1","N/A","http://selleckchem.com/products/dcc-2036.html","C30H28FN7O3","free base","N/A","CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(NC(=O)NC3=CC(=N[N]3C4=CC5=C(C=C4)N=CC=C5)C(C)(C)C)C=C2)F",{"v":5.14,"d":"5.140"},6,3,7]
["S2635","CCT128930","e8","L3000-11","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.",341.84,"885499-61-6",{"v":68,"d":"68.00"},198.92,"<1","N/A","http://selleckchem.com/products/cct128930.html","C18H20ClN5","free base","N/A","NC1(CCN(CC1)C2=C3C=C[NH]C3=NC=N2)CC4=CC=C(Cl)C=C4",2.813,2,2,3]
["S2636","A66","f8","L3000-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","A66 is a potent and specific p110α inhibitor with IC50 of 32 nM in a cell-free assay, >100 fold selectivity for p110α over other class-I PI3K isoforms.",393.53,"1166227-08-2",{"v":79,"d":"79.00"},200.75,"<1","N/A","http://selleckchem.com/products/a66.html","C17H23N5O2S2","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CSC(=N3)C(C)(C)C",2.383,4,2,4]
["S2639","SNX-2112 (PF-04928473)","g8","L3000-11","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.",464.48,"908112-43-6",{"v":93,"d":"93.00"},200.22,"<1","N/A","http://selleckchem.com/products/snx-2112.html","C23H27F3N4O3","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC(=C(C=C3)C(N)=O)NC4CCC(O)CC4",3.709,3,3,5]
["S2656","PF-04929113 (SNX-5422)","h8","L3000-11","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.",521.53,"908115-27-5",{"v":104,"d":"104.00"},199.41,"<1","N/A","http://selleckchem.com/products/pf-04929113.html","C25H30F3N5O4","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC=C(C(N)=O)C(=C3)NC4CCC(CC4)OC(=O)CN",3.126,5,3,8]
["S2658","Omipalisib (GSK2126458)","a9","L3000-11","in 10mM DMSO","Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.",{"v":505.5,"d":"505.50"},"1086062-66-9",{"v":100,"d":"100.00"},197.82,"<1","N/A","http://selleckchem.com/products/gsk2126458.html","C25H17F2N5O3S","free base","GSK458","COC1=NC=C(C=C1N[S](=O)(=O)C2=CC=C(F)C=C2F)C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3",3.705,7,1,6]
["S2660","MK-0752","b9","L3000-11","in 10mM DMSO","Beta Amyloid,Secretase","Proteases","MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.",{"v":442.9,"d":"442.90"},"471905-41-6",{"v":89,"d":"89.00"},200.95,"<1","N/A","http://selleckchem.com/products/mk-0752.html","C21H21ClF2O4S","free base","N/A","OC(=O)CCC1CCC(CC1)(C2=C(F)C=CC(=C2)F)[S](=O)(=O)C3=CC=C(Cl)C=C3",5.615,3,0,6]
["S2661","WYE-125132 (WYE-132)","c9","L3000-11","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.",{"v":519.6,"d":"519.60"},"1144068-46-1",{"v":104,"d":"104.00"},200.15,"<1","N/A","http://selleckchem.com/products/wye-125132.html","C27H33N7O4","free base","N/A","CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7",2.093,7,2,4]
["S2662","Foscenvivint (ICG-001)","d9","L3000-11","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Wnt/beta-catenin","Stem Cells & Wnt","Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.",548.63,"780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry)",{"v":100,"d":"100.00"},182.27,"<1","N/A","http://selleckchem.com/products/icg-001.html","C33H32N4O4","free base","N/A","OC1=CC=C(CC2N3C(CN(CC4=CC=CC5=C4C=CC=C5)C2=O)N(CCC3=O)C(=O)NCC6=CC=CC=C6)C=C1",4.065,3,2,6]
["S2663","WAY-100635 Maleate","e9","L3000-11","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.",538.64,"1092679-51-0",{"v":85,"d":"85.00"},{"v":157.8,"d":"157.80"},"<1","N/A","http://selleckchem.com/products/way-100635.html","C25H34N4O2.C4H4O4","Maleate","N/A","COC1=C(C=CC=C1)N2CCN(CC2)CCN(C(=O)C3CCCCC3)C4=NC=CC=C4.OC(=O)\\C=C/C(O)=O",1.427,5,0,9]
["S2664","Clinofibrate","f9","L3000-11","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.",468.58,"30299-08-2",{"v":94,"d":"94.00"},200.61,"<1","N/A","http://selleckchem.com/products/clinofibrate.html","C28H36O6","free base","N/A","CCC(C)(OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(OC(C)(CC)C(O)=O)C=C3)C(O)=O",6.829,4,0,10]
["S2665","Ciprofibrate","g9","L3000-11","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","Ciprofibrate (Win-35833) is a peroxisome proliferator-activated receptor agonist.",289.15,"52214-84-3",{"v":58,"d":"58.00"},200.59,"<1","N/A","http://selleckchem.com/products/ciprofibrate.html","C13H14Cl2O3","free base","Win-35833","CC(C)(OC1=CC=C(C=C1)C2CC2(Cl)Cl)C(O)=O",2.954,2,0,4]
["S2666","PF-3845","h9","L3000-11","in 10mM DMSO","FAAH","Metabolism","PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.",456.46,"1196109-52-0",{"v":91,"d":"91.00"},199.36,"<1","N/A","http://selleckchem.com/products/pf-3845.html","C24H23F3N4O2","free base","N/A","FC(F)(F)C1=CN=C(OC2=CC(=CC=C2)CC3CCN(CC3)C(=O)NC4=CN=CC=C4)C=C1",{"v":4.55,"d":"4.550"},4,1,6]
["S2670","A-674563","a10","L3000-11","in 10mM DMSO","Akt,CDK,PKA","PI3K/Akt/mTOR","A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.",358.44,"552325-73-2",{"v":72,"d":"72.00"},200.87,{"v":72,"d":"72.00"},200.87,"http://selleckchem.com/products/a-674563.html","C22H22N4O","free base","N/A","CC1=N[NH]C2=C1C=C(C=C2)C3=CN=CC(=C3)OCC(N)CC4=CC=CC=C4",3.212,3,2,6]
["S2671","AS-252424","b10","L3000-11","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AS-252424 is a novel, potent PI3Kγ inhibitor with IC50 of 30 nM in a cell-free assay with 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β.",305.28,"900515-16-4",{"v":61,"d":"61.00"},199.82,"<1","N/A","http://selleckchem.com/products/as-252424.html","C14H8FNO4S","free base","N/A","OC1=C(C=CC(=C1)F)C2=CC=C(O2)\\C=C3/SC(=O)NC3=O",{"v":3.11,"d":"3.110"},3,2,2]
["S2672","PF-00562271 Besylate","c10","L3000-11","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-00562271 Besylate (PF-562271) is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.",665.66,"939791-38-5",{"v":14,"d":"14.00"},21.03,"<1","N/A","http://selleckchem.com/products/pf-00562271.html","C21H20F3N7O3S.C6H6O3S","Benzenesulfonic","PF-562271 Besylate","CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O.O[S](=O)(=O)C5=CC=CC=C5",3.653,6,3,9]
["S2673","Trametinib (GSK1120212)","d10","L3000-11","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.",615.39,"871700-17-3",{"v":22,"d":"22.00"},35.75,"<1","N/A","http://selleckchem.com/products/gsk1120212-jtp-74057.html","C26H23FIN5O4","free base","JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(=CC=C5)NC(C)=O)C",3.176,4,2,5]
["S2679","Flavopiridol (L86-8275) HCl","e10","L3000-11","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.",{"v":438.3,"d":"438.30"},"131740-09-5",{"v":88,"d":"88.00"},200.78,"<1","N/A","http://selleckchem.com/products/flavopiridol-hydrochloride.html","C21H20ClNO5.HCl","Hydrochloride","NSC 649890, Alvocidib, HMR-1275, DSP-2033","Cl.CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,2]
["S2680","Ibrutinib (PCI-32765)","f10","L3000-11","in 10mM DMSO","BTK,Target Protein Ligand","Angiogenesis","Ibrutinib (PCI-32765,Imbruvica) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.",{"v":440.5,"d":"440.50"},"936563-96-1",{"v":88,"d":"88.00"},199.77,"<1","N/A","http://selleckchem.com/products/pci-32765.html","C25H24N6O2","free base","PCI-32765,Imbruvica","NC1=C2C(=NC=N1)[N](N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)C5CCCN(C5)C(=O)C=C",3.985,5,1,5]
["S2683","CHIR-124","g10","L3000-11","in 10mM DMSO","Chk","Cell Cycle","CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.",419.91,"405168-58-3",{"v":7,"d":"7.00"},16.67,"<1","N/A","http://selleckchem.com/products/chir-124.html","C23H22ClN5O","free base","N/A","ClC1=CC2=C(NC(=O)C(=C2NC3CN4CCC3CC4)C5=NC6=C([NH]5)C=CC=C6)C=C1",3.089,2,3,3]
["S2685","KW-2478","h10","L3000-11","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.",574.66,"819812-04-9",{"v":115,"d":"115.00"},200.12,"<1","N/A","http://selleckchem.com/products/kw-2478.html","C30H42N2O9","free base","N/A","CCC1=C(CC(=O)N(CCOC)CCOC)C(=C(O)C=C1O)C(=O)C2=CC=C(OCCN3CCOCC3)C(=C2)OC",2.673,7,2,16]
["S2686","NVP-BSK805 2HCl","a11","L3000-11","in 10mM DMSO","JAK","JAK/STAT","NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.",563.47,"1092499-93-8 (free base)",{"v":113,"d":"113.00"},200.54,{"v":3,"d":"3.00"},5.32,"http://selleckchem.com/products/nvp-bsk805.html","C27H28F2N6O.2HCl","HCl","BSK805","Cl.Cl.FC1=C(CN2CCOCC2)C(=CC(=C1)C3=C4N=C(C=NC4=CC=C3)C5=C[N](N=C5)C6CCNCC6)F",{"v":3.92,"d":"3.920"},4,1,5]
["S2688","R547","b11","L3000-11","in 10mM DMSO","CDK","Cell Cycle","R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.",441.45,"741713-40-6",{"v":60,"d":"60.00"},135.92,"<1","N/A","http://selleckchem.com/products/r547.html","C18H21F2N5O4S","free base","Ro 4584820","COC1=CC=C(F)C(=C1C(=O)C2=C(N)N=C(NC3CCN(CC3)[S](C)(=O)=O)N=C2)F",1.133,6,2,6]
["S2689","WAY-600","c11","L3000-11","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",494.59,"1062159-35-6",{"v":22,"d":"22.00"},44.48,"<1","N/A","http://selleckchem.com/products/way-600.html","C28H30N8O","free base","N/A","C1CN(CCO1)C2=NC(=NC3=C2C=N[N]3C4CCN(CC4)CC5=CC=CN=C5)C6=CC7=C([NH]C=C7)C=C6",2.946,5,1,5]
["S2692","TG101209","d11","L3000-11","in 10mM DMSO","c-RET,FLT3,JAK","JAK/STAT","TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.",509.67,"936091-14-4",{"v":102,"d":"102.00"},200.13,"<1","N/A","http://selleckchem.com/products/tg101209.html","C26H35N7O2S","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(C)C(=N3)NC4=CC(=CC=C4)[S](=O)(=O)NC(C)(C)C)C=C2",4.659,4,3,8]
["S2693","Resminostat","e11","L3000-11","in 10mM DMSO","HDAC","Epigenetics","Resminostat (RAS2410) dose-dependently and selectively inhibits HDAC1/3/6 with IC50 of 42.5 nM/50.1 nM/71.8 nM, less potent to HDAC8 with IC50 of 877 nM.",{"v":349.4,"d":"349.40"},"864814-88-0",{"v":70,"d":"70.00"},200.34,"<1","N/A","http://selleckchem.com/products/resminostat-ras2410.html","C16H19N3O4S","free base","RAS2410","CN(C)CC1=CC=C(C=C1)[S](=O)(=O)[N]2C=CC(=C2)\\C=C\\C(=O)NO",1.837,3,1,6]
["S2694","Turofexorate Isopropyl (XL335)","f11","L3000-11","in 10mM DMSO","FXR","Metabolism","Turofexorate Isopropyl (XL335, Fxr 450) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.",438.47,"629664-81-9",{"v":33,"d":"33.00"},75.26,"<1","N/A","http://selleckchem.com/products/way-362450.html","C25H24F2N2O3","free base","Fxr 450","CC(C)OC(=O)C1=CN(CC(C)(C)C2=C1[NH]C3=CC=CC=C23)C(=O)C4=CC=C(F)C(=C4)F",4.968,3,1,4]
["S2695","Nepicastat (SYN-117) HCl","g11","L3000-11","in 10mM DMSO","Hydroxylase","Metabolism","Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.",331.81,"170151-24-3",{"v":66,"d":"66.00"},198.91,"<1","N/A","http://selleckchem.com/products/nepicastat-hydrochloride.html","C14H15F2N3S.HCl","Hydrochloride","N/A","Cl.NCC1=CNC(=S)N1C2CCC3=C(F)C=C(F)C=C3C2",3.008,0,2,2]
["S2696","Apitolisib (GDC-0980)","h11","L3000-11","in 10mM DMSO","Apoptosis related,Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.",{"v":498.6,"d":"498.60"},"1032754-93-0",{"v":20,"d":"20.00"},40.11,"<1","N/A","http://selleckchem.com/products/GDC-0980-RG7422.html","C23H30N8O3S","free base","RG7422, GNE 390","CC(O)C(=O)N1CCN(CC1)CC2=C(C)C3=NC(=NC(=C3S2)N4CCOCC4)C5=CN=C(N)N=C5",1.013,6,2,5]
["S2697","A-769662","a2","L3000-12","in 10mM DMSO","AMPK,Fatty Acid Synthase","PI3K/Akt/mTOR","A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.",360.39,"844499-71-4",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/a-769662.html","C20H12N2O3S","free base","N/A","OC1=CC=CC=C1C2=CC=C(C=C2)C3=CSC4=C3C(=C(C#N)C(=O)N4)O",3.135,1,3,2]
["S2699","CH5132799","b2","L3000-12","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CH5132799 (MEN1611, PA799) inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.",377.42,"1007207-67-1",{"v":12,"d":"12.00"},31.79,"<1","N/A","http://selleckchem.com/products/ch5132799.html","C15H19N7O3S","free base","MEN1611, PA799","C[S](=O)(=O)N1CCC2=C(N=C(N=C12)N3CCOCC3)C4=CN=C(N)N=C4",0.095,7,1,3]
["S2700","Tirbanibulin","c2","L3000-12","in 10mM DMSO","Src","Angiogenesis","Tirbanibulin(KX2-391,KX 01), the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Phase 2.",431.53,"897016-82-9",{"v":86,"d":"86.00"},199.29,"<1","N/A","http://selleckchem.com/products/kx2-391.html","C26H29N3O3","free base","KX2-391,KX 01","O=C(CC1=CC=C(C=N1)C2=CC=C(OCCN3CCOCC3)C=C2)NCC4=CC=CC=C4",3.262,4,1,9]
["S2703","GSK1838705A","d2","L3000-12","in 10mM DMSO","ALK,IGF-1R","Protein Tyrosine Kinase","GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.",532.57,"1116235-97-2",{"v":107,"d":"107.00"},200.91,"<1","N/A","http://selleckchem.com/products/gsk1838705a.html","C27H29FN8O3","free base","N/A","CNC(=O)C1=C(F)C=CC=C1NC2=C3C=C[NH]C3=NC(=N2)NC4=C(OC)C=C5CCN(C(=O)CN(C)C)C5=C4",3.508,5,4,8]
["S2711","Dibenzazepine (YO-01027)","e2","L3000-12","in 10mM DMSO","Notch,Secretase","Proteases","Dibenzazepine (YO-01027, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM  in cell-free assays for APPL and Notch cleavage, respectively.",463.48,"209984-56-5",{"v":92,"d":"92.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/yo-01027.html","C26H23F2N3O3","free base","DBZ","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC2C(=O)N(C)C3=C(C=CC=C3)C4=C2C=CC=C4",3.277,3,2,5]
["S2713","Geldanamycin (NSC 122750)","f2","L3000-12","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Antiviral,Autophagy,HSP (HSP90)","Cytoskeletal Signaling","Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.",560.64,"30562-34-6",{"v":36,"d":"36.00"},64.21,"<1","N/A","http://selleckchem.com/products/geldanamycin.html","C29H40N2O9","free base","NSC 122750","COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)\\C(=C\\C=C\\C(OC)C(OC(N)=O)\\C(=C\\C(C)C1O)C)C)C2=O",{"v":2.36,"d":"2.360"},8,3,5]
["S2714","LY411575","g2","L3000-12","in 10mM DMSO","Apoptosis related,Notch,Secretase","Proteases","LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells. LY411575 induces apoptosis.",479.48,"209984-57-6",{"v":95,"d":"95.00"},198.13,"<1","N/A","http://selleckchem.com/products/ly-411575.html","C26H23F2N3O4","free base","N/A","CC(NC(=O)C(O)C1=CC(=CC(=C1)F)F)C(=O)NC2C(=O)N(C)C3=C(C=CC=C3)C4=C2C=CC=C4",2.625,3,3,5]
["S2718","TAK-901","h2","L3000-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.",504.64,"934541-31-8",{"v":101,"d":"101.00"},200.14,"<1","N/A","http://selleckchem.com/products/tak-901.html","C28H32N4O3S","free base","N/A","CC[S](=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C)C3=C2C4=C([NH]3)N=CC(=C4)C)C(=O)NC5CCN(C)CC5",4.056,4,2,5]
["S2719","AMG-900","a3","L3000-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.",503.58,"945595-80-2",{"v":100,"d":"100.00"},198.58,"<1","N/A","http://selleckchem.com/products/amg-900.html","C28H21N7OS","free base","N/A","CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=C(C=CC=N4)C5=NC(=NC=C5)N)C=C3)C6=C2C=CC=C6",6.487,6,2,6]
["S2720","ZM 336372","b3","L3000-12","in 10mM DMSO","Raf","MAPK","ZM 336372 (Zinc00581684) is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.",389.45,"208260-29-1",{"v":78,"d":"78.00"},200.28,"<1","N/A","http://selleckchem.com/products/zm-336372.html","C23H23N3O3","free base","Zinc00581684","CN(C)C1=CC=CC(=C1)C(=O)NC2=CC(=C(C)C=C2)NC(=O)C3=CC=C(O)C=C3",3.805,2,3,5]
["S2722","JTC-801","c3","L3000-12","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.",447.96,"244218-51-7",{"v":90,"d":"90.00"},200.91,"<1","N/A","http://selleckchem.com/products/jtc-801.html","C26H25N3O2.HCl","Hydrochloride","N/A","Cl.CCC1=CC=C(OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C)C=C4N)C=C1",5.228,3,2,6]
["S2726","PH-797804","d3","L3000-12","in 10mM DMSO","p38 MAPK","MAPK","PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.",{"v":477.3,"d":"477.30"},"586379-66-0",{"v":96,"d":"96.00"},201.13,"<1","N/A","http://selleckchem.com/products/ph-797804.html","C22H19BrF2N2O3","free base","N/A","CNC(=O)C1=CC(=C(C)C=C1)N2C(=CC(=C(Br)C2=O)OCC3=CC=C(F)C=C3F)C",3.801,3,1,5]
["S2727","Dacomitinib (PF-00299804)","e3","L3000-12","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Dacomitinib (PF299804, PF299) is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.",469.94,"1110813-31-4",{"v":19,"d":"19.00"},40.43,"<1","N/A","http://selleckchem.com/products/pf299804.html","C24H25ClFN5O2","free base","PF299804,PF299","COC1=C(NC(=O)/C=C/CN2CCCCC2)C=C3C(=NC=NC3=C1)NC4=CC(=C(F)C=C4)Cl",5.055,4,2,7]
["S2728","AG-1478 (Tyrphostin AG-1478)","f3","L3000-12","in 10mM DMSO","EGFR,HCV,PI4K","Protein Tyrosine Kinase","AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).",315.75,"153436-53-4,175178-82-2",{"v":25,"d":"25.00"},79.18,"<1","N/A","http://selleckchem.com/products/ag-1478-tyrphostin-ag-1478.html","C16H14ClN3O2","free base","NSC 693255","COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)Cl",4.109,4,1,4]
["S2730","Crenolanib (CP-868596)","g3","L3000-12","in 10mM DMSO","FLT3,Mitophagy,PDGFR","Protein Tyrosine Kinase","Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.",443.54,"670220-88-9",{"v":88,"d":"88.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/crenolanib-cp-868596.html","C26H29N5O2","free base","ARO 002","CC1(COC1)COC2=CC3=C(C=C2)[N](C=N3)C4=NC5=C(C=CC=C5C=C4)N6CCC(N)CC6",3.192,4,1,5]
["S2731","AZ 3146","h3","L3000-12","in 10mM DMSO","MPS1","Cell Cycle","AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.",452.55,"1124329-14-1",{"v":28,"d":"28.00"},61.87,"<1","N/A","http://selleckchem.com/products/az-3146.html","C24H32N6O3","free base","N/A","COC1=C(NC2=NC3=C(C=N2)N(C)C(=O)N3C4CCCC4)C=CC(=C1)OC5CCN(C)CC5",3.416,5,1,6]
["S2736","Fedratinib (TG101348)","a4","L3000-12","in 10mM DMSO","Apoptosis related,c-RET,FLT3,JAK","JAK/STAT","Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.",524.68,"936091-26-8",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/Fedratinib-SAR302503-TG101348.html","C27H36N6O3S","free base","SAR302503","CC1=C(NC2=CC=CC(=C2)[S](=O)(=O)NC(C)(C)C)N=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=C1",5.123,5,3,11]
["S2738","PAC-1","b4","L3000-12","in 10mM DMSO","Caspase","Apoptosis","PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.",392.49,"315183-21-2",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/pac-1.html","C23H28N4O2","free base","N/A","OC1=C(CC=C)C=CC=C1/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3",3.331,2,2,8]
["S2740","GSK1070916","c4","L3000-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.",507.63,"942918-07-2",{"v":93,"d":"93.00"},{"v":183.2,"d":"183.20"},"<1","N/A","http://selleckchem.com/products/gsk1070916.html","C30H33N7O","free base","N/A","CC[N]1C=C(C2=C3C=C([NH]C3=NC=C2)C4=CC=CC(=C4)CN(C)C)C(=N1)C5=CC=C(NC(=O)N(C)C)C=C5",4.841,3,2,7]
["S2741","Niraparib (MK-4827)","d4","L3000-12","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.",320.39,"1038915-60-4",{"v":64,"d":"64.00"},199.76,"<1","N/A","http://selleckchem.com/products/mk-4827.html","C19H20N4O","Free Base","N/A","NC(=O)C1=CC=CC2=C[N](N=C12)C3=CC=C(C=C3)C4CCCNC4",2.618,2,2,3]
["S2742","PHA-767491 HCl","e4","L3000-12","in 10mM DMSO","CDK","Cell Cycle","PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.",{"v":249.7,"d":"249.70"},"942425-68-5",{"v":24,"d":"24.00"},96.12,"<1","N/A","http://selleckchem.com/products/pha-767491.html","C12H11N3O.HCl","HCl","CAY10572, NMS 1116354","O=C1NCCC2=C1C=C([NH]2)C3=CC=NC=C3",1.252,2,2,1]
["S2743","PF-04691502","f4","L3000-12","in 10mM DMSO","Akt,Apoptosis related,mTOR,PI3K","PI3K/Akt/mTOR","PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.",425.48,"1013101-36-4",{"v":14,"d":"14.00"},{"v":32.9,"d":"32.90"},"<1","N/A","http://selleckchem.com/products/pf-04691502.html","C22H27N5O4","free base","PF4691502","COC1=CC=C(C=N1)C2=CC3=C(C)N=C(N)N=C3N(C4CCC(CC4)OCCO)C2=O",1.616,6,2,6]
["S2745","CHIR-98014","g4","L3000-12","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","CHIR-98014 (CT98014) is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.",486.31,"252935-94-7",{"v":8,"d":"8.00"},16.45,"<1","N/A","http://selleckchem.com/products/chir-98014.html","C20H17Cl2N9O2","free base","CT98014","NC1=NC(=CC=C1[N+]([O-])=O)NCCNC2=NC=C([N]3C=CN=C3)C(=N2)C4=CC=C(Cl)C=C4Cl",3.859,4,3,8]
["S2746","AZ 628","h4","L3000-12","in 10mM DMSO","Apoptosis related,Raf","MAPK","AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.",451.52,"878739-06-1",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://selleckchem.com/products/az628.html","C27H25N5O2","free base","N/A","CN1C=NC2=C(C=C(NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)C=C2)C1=O",{"v":4.57,"d":"4.570"},3,2,5]
["S2747","AMG-458","a5","L3000-12","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.",539.58,"913376-83-7",{"v":21,"d":"21.00"},38.92,"<1","N/A","http://selleckchem.com/products/amg458.html","C30H29N5O5","free base","N/A","COC1=CC2=NC=CC(=C2C=C1)OC3=CN=C(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)C5=CC=CC=C5)C=C3",3.125,6,1,8]
["S2749","BGT226 (NVP-BGT226) maleate","b5","L3000-12","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.",{"v":650.6,"d":"650.60"},"1245537-68-1",{"v":30,"d":"30.00"},46.11,"<1","N/A","http://selleckchem.com/products/nvp-bgt226.html","C28H25F3N6O2.C4H4O","maleate","N/A","COC1=NC=C(C=C1)C2=CC=C3N=CC4=C(N(C(=O)N4C)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F)C3=C2.OC(=O)\\C=C/C(O)=O",1.618,6,1,7]
["S2750","GW788388","c5","L3000-12","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.",425.48,"452342-67-5",{"v":15,"d":"15.00"},35.25,"<1","N/A","http://selleckchem.com/products/gw788388.html","C25H23N5O2","free base","N/A","O=C(NC1CCOCC1)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C[NH]N=C4C5=NC=CC=C5",2.862,5,2,5]
["S2751","Milciclib (PHA-848125)","d5","L3000-12","in 10mM DMSO","Autophagy,CDK","Cell Cycle","Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.",460.57,"802539-81-7",{"v":92,"d":"92.00"},199.75,"<1","N/A","http://selleckchem.com/products/pha-848125.html","C25H32N8O","free base","N/A","CNC(=O)C1=N[N](C)C2=C1C(C)(C)CC3=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N=C23",3.825,4,2,4]
["S2752","HER2-Inhibitor-1","e5","L3000-12","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","HER2-Inhibitor-1 is an analog of ARRY-380. ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.",569.63,"937265-83-3",{"v":100,"d":"100.00"},175.55,"<1","N/A","http://selleckchem.com/products/her2-inhibitor-1.html","C29H27N7O4S","free base","N/A","CC1=CC(=CC=C1OC2=CC3=NC=N[N]3C=C2)NC4=C5C=C(C=CC5=NC=N4)C6=CC=C(CNCC[S](C)(=O)=O)O6",4.446,8,2,10]
["S2753","Tivantinib (ARQ 197)","f5","L3000-12","in 10mM DMSO","Apoptosis related,c-Met","Protein Tyrosine Kinase","Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.",369.42,"905854-02-6",{"v":73,"d":"73.00"},197.61,"<1","N/A","http://selleckchem.com/products/arq-197.html","C23H19N3O2","free base","N/A","O=C1NC(=O)C(C1C2=C[NH]C3=C2C=CC=C3)C4=C[N]5CCCC6=CC=CC4=C56",{"v":3.52,"d":"3.520"},2,2,2]
["S2754","Xevinapant (AT406)","g5","L3000-12","in 10mM DMSO","E3 Ligase ,IAP","Apoptosis","Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.",561.71,"1071992-99-8",{"v":100,"d":"100.00"},178.03,"<1","N/A","http://selleckchem.com/products/at-406.html","C32H43N5O4","free base","ARRY-334543, Debio1143, SM-406","CNC(C)C(=O)NC1CN(CCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C",2.264,4,3,9]
["S2755","Varlitinib","h5","L3000-12","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Varlitinib (ARRY334543) is a selective and potent ErbB1(EGFR) and ErbB2(HER2) inhibitor with IC50 of 7 nM and 2 nM, respectively. Phase 2.",466.94,"845272-21-1",{"v":6,"d":"6.00"},12.85,"<1","N/A","http://selleckchem.com/products/arry334543.html","C22H19ClN6O2S","free base","ARRY334543","CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(OCC5=NC=CS5)C=C4)Cl",4.577,6,2,7]
["S2757","Evofosfamide (TH-302)","a6","L3000-12","in 10mM DMSO","Others","Others","Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.",449.04,"918633-87-1",{"v":90,"d":"90.00"},200.43,{"v":10,"d":"10.00"},22.27,"http://selleckchem.com/products/th-302.html","C9H16Br2N5O4P","free base","Evofosfamide","C[N]1C(=CN=C1[N+]([O-])=O)CO[P](=O)(NCCBr)NCCBr",0.537,3,2,10]
["S2759","Fimepinostat (CUDC-907)","b6","L3000-12","in 10mM DMSO","Apoptosis related,HDAC,PI3K","Cytoskeletal Signaling","CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1.",508.55,"1339928-25-4",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/pi3k-hdac-inhibitor-i.html","C23H24N8O4S","free base","N/A","COC1=CC=C(C=N1)C2=NC3=C(SC(=C3)CN(C)C4=NC=C(C=N4)C(=O)NO)C(=N2)N5CCOCC5",2.303,8,1,7]
["S2760","Canagliflozin (JNJ 28431754)","c6","L3000-12","in 10mM DMSO","SGLT","GPCR & G Protein","Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.",444.52,"842133-18-0",{"v":88,"d":"88.00"},197.97,"<1","N/A","http://selleckchem.com/products/canagliflozin.html","C24H25FO5S","free base","TA 7284","CC1=C(CC2=CC=C(S2)C3=CC=C(F)C=C3)C=C(C=C1)C4OC(CO)C(O)C(O)C4O",3.446,1,4,5]
["S2761","NVP-BVU972","d6","L3000-12","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","NVP-BVU972 is a selective and potent Met (c-Met) inhibitor with IC50 of 14 nM.",340.38,"1185763-69-2",{"v":68,"d":"68.00"},199.78,"<1","N/A","http://selleckchem.com/products/nvp-bvu972.html","C20H16N6","free base","N/A","C[N]1C=C(C=N1)C2=N[N]3C(=CN=C3C=C2)CC4=CC=C5N=CC=CC5=C4",2.867,4,0,3]
["S2762","Alectinib (CH5424802)","e6","L3000-12","in 10mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (CH5424802, AF-802, RG-7853) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.",482.62,"1256580-46-7",{"v":6,"d":"6.00"},12.43,{"v":1,"d":"1.00"},2.07,"http://www.selleckchem.com/products/ch5424802.html","C30H34N4O2","Free Base","AF-802, RG-7853,CH5424802","CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C)(C)C5=C(C2=O)C6=CC=C(C=C6[NH]5)C#N",5.203,2,1,3]
["S2768","Dinaciclib (SCH727965)","f6","L3000-12","in 10mM DMSO","Caspase,CDK","Cell Cycle","Dinaciclib (SCH727965, PS-095760) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.",396.49,"779353-01-4",{"v":26,"d":"26.00"},65.58,"<1","N/A","http://selleckchem.com/products/dinaciclib-sch727965.html","C21H28N6O2","free base","PS-095760","CCC1=C2N=C(C=C(NCC3=CC=C[N+](=C3)[O-])[N]2N=C1)N4CCCCC4CCO",2.152,2,2,7]
["S2769","Dovitinib (TKI-258) Dilactic Acid","g6","L3000-12","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.",572.59,"852433-84-2",{"v":90,"d":"90.00"},157.18,{"v":70,"d":"70.00"},122.25,"http://selleckchem.com/products/dovitinib.html","C27H33FN6O7","Dilactic Acid","N/A","CC(O)C(O)=O.CC(O)C(O)=O.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(NC4=O)C=CC=C5F",-2.038,4,5,4]
["S2770","MK-5108 (VX-689)","h6","L3000-12","in 10mM DMSO","Aurora Kinase,Autophagy","Cell Cycle","MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.",461.94,"1010085-13-8",{"v":92,"d":"92.00"},199.16,"<1","N/A","http://selleckchem.com/products/mk-5108-vx-689.html","C22H21ClFN3O3S","free base","N/A","OC(=O)C1(CCC(CC1)OC2=C(F)C(=CC=C2)Cl)CC3=CC=CC(=N3)NC4=NC=CS4",5.574,4,1,7]
["S2772","Dalcetrapib (JTT-705)","a7","L3000-12","in 10mM DMSO","CETP","Metabolism","Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3.",389.59,"211513-37-0",{"v":78,"d":"78.00"},200.21,"<1","N/A","http://selleckchem.com/products/dalcetrapib-jtt-705.html","C23H35NO2S","free base","RO4607381","CCC(CC)CC1(CCCCC1)C(=O)NC2=C(SC(=O)C(C)C)C=CC=C2",7.025,2,1,9]
["S2773","SB705498","b7","L3000-12","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.",429.23,"501951-42-4",{"v":86,"d":"86.00"},200.36,"<1","N/A","http://selleckchem.com/products/sb705498.html","C17H16BrF3N4O","free base","N/A","FC(F)(F)C1=CN=C(C=C1)N2CCC(C2)NC(=O)NC3=CC=CC=C3Br",3.745,2,2,4]
["S2774","MK-2461","c7","L3000-12","in 10mM DMSO","c-Met,FGFR,PDGFR,RON","Protein Tyrosine Kinase","MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.",495.55,"917879-39-1",{"v":99,"d":"99.00"},199.78,"<1","N/A","http://selleckchem.com/products/mk-2461.html","C24H25N5O5S","free base","N/A","CN(CC1COCCO1)[S](=O)(=O)NC2=CC3=C(C=C2)C=CC4=C(C=C(C=N4)C5=C[N](C)N=C5)C3=O",0.924,7,1,6]
["S2775","Nocodazole (R17934)","d7","L3000-12","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,CRISPR/Cas9,Microtubule Associated","Cytoskeletal Signaling","Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.",301.32,"31430-18-9",{"v":7,"d":"7.00"},23.23,"<1","N/A","http://selleckchem.com/products/nocodazole.html","C14H11N3O3S","free base","Oncodazole, NSC238159","COC(=O)NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CS3",3.008,4,2,4]
["S2776","Devimistat (CPI-613)","e7","L3000-12","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells. Phase 2.",388.59,"95809-78-2",{"v":77,"d":"77.00"},198.15,"<1","N/A","http://selleckchem.com/products/cpi-613.html","C22H28O2S2","free base","N/A","OC(=O)CCCCC(CCSCC1=CC=CC=C1)SCC2=CC=CC=C2",{"v":5.63,"d":"5.630"},1,0,13]
["S2777","PF-5274857","f7","L3000-12","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.",436.96,"1373615-35-0",{"v":93,"d":"93.00"},212.83,{"v":93,"d":"93.00"},212.83,"http://selleckchem.com/products/pf-5274857.html","C20H25ClN4O3S","free base","N/A","CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CC[S](C)(=O)=O)C",2.744,5,0,5]
["S2778","GW842166X","g7","L3000-12","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.",449.25,"666260-75-9",{"v":20,"d":"20.00"},44.52,"<1","N/A","http://selleckchem.com/products/gw-842166x.html","C18H17Cl2F3N4O2","free base","N/A","FC(F)(F)C1=NC(=NC=C1C(=O)NCC2CCOCC2)NC3=CC=C(Cl)C=C3Cl",4.449,4,2,6]
["S2779","M344","h7","L3000-12","in 10mM DMSO","HDAC","Cytoskeletal Signaling","M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.",307.39,"251456-60-7",{"v":62,"d":"62.00"},{"v":201.7,"d":"201.70"},"<1","N/A","http://selleckchem.com/products/m344.html","C16H25N3O3","free base","N/A","CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO",2.004,2,2,9]
["S2780","I-BET151 (GSK1210151A)","a8","L3000-12","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","I-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM in cell-free assays, respectively.",415.44,"1300031-49-5",{"v":83,"d":"83.00"},199.79,"<1","N/A","http://www.selleck.cn/products/i-bet151-gsk1210151a.html","C23H21N5O3","Free Base","N/A","COC1=C(C=C2N=CC3=C(N(C(C)C4=CC=CC=N4)C(=O)N3)C2=C1)C5=C(C)ON=C5C",2.601,6,1,4]
["S2781","RITA (NSC 652287)","b8","L3000-12","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2782","GW4064","c8","L3000-12","in 10mM DMSO","Autophagy,FXR","Metabolism","GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM. GW4064 stimulates autophagy in MCF-7 cells.",542.84,"278779-30-9",{"v":100,"d":"100.00"},184.22,"<1","N/A","http://selleckchem.com/products/gw-4064.html","C28H22Cl3NO4","free base","N/A","CC(C)C1=C(COC2=CC(=C(C=C2)/C=C/C3=CC=CC(=C3)C(O)=O)Cl)C(=NO1)C4=C(Cl)C=CC=C4Cl",8.682,4,0,8]
["S2783","Vistusertib (AZD2014)","d8","L3000-12","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.",462.54,"1009298-59-2",{"v":38,"d":"38.00"},82.16,"<1","N/A","http://selleckchem.com/products/azd2014.html","C25H30N6O3","free base","N/A","CNC(=O)C1=CC=CC(=C1)C2=CC=C3C(=N2)N=C(N=C3N4CCOCC4C)N5CCOCC5C",3.103,6,1,4]
["S2784","TAK-285","e8","L3000-12","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.",547.96,"871026-44-7",{"v":110,"d":"110.00"},200.74,"<1","N/A","http://selleckchem.com/products/tak-285.html","C26H25ClF3N5O3","free base","N/A","CC(C)(O)CC(=O)NCC[N]1C=CC2=C1C(=NC=N2)NC3=CC=C(OC4=CC=CC(=C4)C(F)(F)F)C(=C3)Cl",5.586,4,2,10]
["S2785","A-803467","f8","L3000-12","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.",357.79,"944261-79-4",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/a-803467.html","C19H16ClNO4","free base","N/A","COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(Cl)C=C3)OC",4.451,4,1,5]
["S2789","Tofacitinib (CP-690550)","g8","L3000-12","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.",312.37,"477600-75-2",{"v":62,"d":"62.00"},198.48,"<1","N/A","http://selleckchem.com/products/tofacitinib-cp-690550.html","C16H20N6O","free base","Tasocitinib","CC1CCN(CC1N(C)C2=C3C=C[NH]C3=NC=N2)C(=O)CC#N",1.512,3,1,3]
["S2790","Istradefylline","h8","L3000-12","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.",384.43,"155270-99-8",{"v":6,"d":"6.00"},15.61,"<1","N/A","http://selleckchem.com/products/istradefylline-kw-6002.html","C20H24N4O4","free base","KW-6002","CCN1C(=O)N(CC)C2=C([N](C)C(=N2)\\C=C\\C3=CC=C(OC)C(=C3)OC)C1=O",2.957,5,0,6]
["S2791","Sotrastaurin (AEB071)","a9","L3000-12","in 10mM DMSO","PKC","TGF-beta/Smad","Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.",438.48,"425637-18-9",{"v":87,"d":"87.00"},198.41,"<1","N/A","http://selleckchem.com/products/sotrastaurin-aeb071.html","C25H22N6O2","free base","AEB071","CN1CCN(CC1)C2=NC(=C3C=CC=CC3=N2)C4=C(C(=O)NC4=O)C5=C[NH]C6=C5C=CC=C6",3.483,4,2,3]
["S2792","Torcetrapib","b9","L3000-12","in 10mM DMSO","CETP","Metabolism","Torcetrapib (CP-529414) is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3.",600.47,"262352-17-0",{"v":120,"d":"120.00"},199.84,"<1","N/A","http://selleckchem.com/products/torcetrapib-cp-529414.html","C26H25F9N2O4","free base","CP-529414","CCOC(=O)N1C(CC)CC(N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C(=O)OC)C3=C1C=CC(=C3)C(F)(F)F",7.345,4,0,10]
["S2796","WP1066","c9","L3000-12","in 10mM DMSO","Apoptosis related,JAK,STAT","JAK/STAT","WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.",356.22,"857064-38-1",{"v":71,"d":"71.00"},199.32,"<1","N/A","http://selleckchem.com/products/wp1066.html","C17H14BrN3O","free base","N/A","CC(NC(=O)\\C(=C\\C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",3.566,2,1,4]
["S2797","Lonafarnib (SCH66336)","d9","L3000-12","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2799","Daporinad","e9","L3000-12","in 10mM DMSO","Autophagy,NAMPT,Transferase","Metabolism","Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.",391.51,"658084-64-1",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://www.selleck.cn/products/apo866-fk866.html","C24H29N3O2","Free Base","FK866, APO866","O=C(NCCCCC1CCN(CC1)C(=O)C2=CC=CC=C2)/C=C/C3=CC=CN=C3",3.269,3,1,8]
["S2801","AZD4547","f9","L3000-12","in 10mM DMSO","FGFR","Angiogenesis","AZD4547 (ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.",463.57,"1035270-39-3",{"v":92,"d":"92.00"},198.46,"<1","N/A","http://selleckchem.com/products/azd4547.html","C26H33N5O3","free base","ABSK 091","COC1=CC(=CC(=C1)OC)CCC2=CC(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CC(C)NC(C)C4",4.204,4,3,8]
["S2803","Galeterone","g9","L3000-12","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Endocrinology & Hormones","Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.",388.55,"851983-85-2",{"v":24,"d":"24.00"},61.77,"<1","N/A","http://selleckchem.com/products/galeterone-tok-001.html","C26H32N2O","free base","TOK-001","CC12CCC(O)CC1=CCC3C2CCC4(C)C3CC=C4[N]5C=NC6=C5C=CC=C6",4.897,1,1,1]
["S2804","Sirtinol","h9","L3000-12","in 10mM DMSO","Sirtuin","Epigenetics","Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.",394.47,"410536-97-9",{"v":23,"d":"23.00"},58.31,"<1","N/A","http://selleckchem.com/products/sirtinol.html","C26H22N2O2","free base","N/A","CC(NC(=O)C1=CC=CC=C1N=CC2=C3C=CC=CC3=CC=C2O)C4=CC=CC=C4",5.262,2,2,5]
["S2806","CEP-33779","a10","L3000-12","in 10mM DMSO","JAK","JAK/STAT","CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM, >40- and >800-fold versus JAK1 and TYK2.",462.57,"1257704-57-6",{"v":36,"d":"36.00"},77.83,"<1","N/A","http://selleckchem.com/products/cep33779.html","C24H26N6O2S","free base","N/A","CN1CCN(CC1)C2=CC=CC(=C2)NC3=N[N]4C=CC=C(C5=CC=C(C=C5)[S](C)(=O)=O)C4=N3",{"v":3.86,"d":"3.860"},4,1,5]
["S2807","Dabrafenib (GSK2118436)","b10","L3000-12","in 10mM DMSO","Raf","MAPK","Dabrafenib (GSK2118436, GSK2118436A) is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.",519.56,"1195765-45-7",{"v":30,"d":"30.00"},57.74,"<1","N/A","http://selleckchem.com/products/dabrafenib-gsk2118436.html","C23H20F3N5O2S2","free base","GSK2118436A","CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F",5.377,5,2,6]
["S2808","Ipatasertib (GDC-0068)","c10","L3000-12","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Ipatasertib (GDC-0068, RG7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.",{"v":458,"d":"458.00"},"1001264-89-6",{"v":92,"d":"92.00"},200.87,"<1","N/A","http://selleckchem.com/products/gdc-0068.html","C24H32ClN5O2","free base","RG7440","CC(C)NCC(C(=O)N1CCN(CC1)C2=C3C(C)CC(O)C3=NC=N2)C4=CC=C(Cl)C=C4",3.102,3,2,6]
["S2811","Sapanisertib (MLN0128)","d10","L3000-12","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.",309.33,"1224844-38-5",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://selleckchem.com/products/ink128.html","C15H15N7O","free base","INK 128,TAK-228","CC(C)[N]1N=C(C2=CC3=C(OC(=N3)N)C=C2)C4=C(N)N=CN=C14",1.886,5,2,2]
["S2812","(R)-(-)-Gossypol acetic acid","e10","L3000-12","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2","Apoptosis","(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.",578.61,"866541-93-7",{"v":116,"d":"116.00"},200.48,"<1","N/A","https://www.selleckchem.com/products/at101-acetic-acid.html","C30H30O8.C2H4O2","free base","AT-101 acetic acid, (-)-Gossypol acetic acid, (R)-Gossypol acetic acid","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(C)C=C4C(=C(O)C(=C(C=O)C4=C3O)O)C(C)C)O.CC(O)=O",6.388,3,6,5]
["S2813","Ciproxifan Maleate","f10","L3000-12","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ciproxifan (FUB 359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.",{"v":386.4,"d":"386.40"},"184025-19-2",{"v":54,"d":"54.00"},139.75,{"v":1,"d":"1.00"},2.59,"http://selleckchem.com/products/ciproxifan.html","C16H18N2O2.C4H4O4","Maleate","FUB 359","OC(=O)\\C=C/C(O)=O.O=C(C1CC1)C2=CC=C(OCCCC3=C[NH]C=N3)C=C2",2.605,5,1,9]
["S2814","Alpelisib (BYL719)","g10","L3000-12","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.",441.47,"1217486-61-7",{"v":88,"d":"88.00"},199.33,"<1","N/A","http://selleckchem.com/products/byl719.html","C19H22F3N5O2S","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CC(=NC=C3)C(C)(C)C(F)(F)F",2.826,4,2,5]
["S2816","Tyrphostin AG 879","h10","L3000-12","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.",316.46,"148741-30-4",{"v":36,"d":"36.00"},113.76,"<1","N/A","http://selleckchem.com/products/tyrphostin-ag-879-ag-879.html","C18H24N2OS","free base","AG 879","CC(C)(C)C1=C(O)C(=CC(=C1)/C=C(C#N)/C(N)=S)C(C)(C)C",4.565,0,2,4]
["S2817","Torin 2","a11","L3000-12","in 10mM DMSO","Apoptosis related,ATM/ATR,Autophagy,DNA-PK,mTOR","PI3K/Akt/mTOR","Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.",{"v":432.4,"d":"432.40"},"1223001-51-1",{"v":20,"d":"20.00"},46.25,"<1","N/A","http://selleckchem.com/products/torin-2.html","C24H15F3N4O","free base","N/A","NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(=O)C=C4)C5=CC=CC(=C5)C(F)(F)F)C3=C2",4.323,3,1,3]
["S2818","Tacedinaline (CI994)","b11","L3000-12","in 10mM DMSO","HDAC","Epigenetics","Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.",{"v":269.3,"d":"269.30"},"112522-64-2",{"v":54,"d":"54.00"},200.52,"<1","N/A","http://selleckchem.com/products/ci994-tacedinaline.html","C15H15N3O2","free base","PD-123654, GOE-5549, Acetyldinaline","CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N)C=CC=C2",0.988,2,3,3]
["S2819","AM251","c11","L3000-12","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain.",555.24,"183232-66-8",{"v":40,"d":"40.00"},72.04,"<1","N/A","http://selleckchem.com/products/am251.html","C22H21Cl2IN4O","free base","N/A","CC1=C([N](N=C1C(=O)NN2CCCCC2)C3=CC=C(Cl)C=C3Cl)C4=CC=C(I)C=C4",6.527,2,1,4]
["S2820","TAE226 (NVP-TAE226)","d11","L3000-12","in 10mM DMSO","Apoptosis related,FAK,Pyk2","Angiogenesis","TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.",468.94,"761437-28-9",{"v":94,"d":"94.00"},200.45,"<1","N/A","http://selleckchem.com/products/nvp-tae226.html","C23H25ClN6O3","free base","N/A","CNC(=O)C1=C(NC2=C(Cl)C=NC(=N2)NC3=C(OC)C=C(C=C3)N4CCOCC4)C=CC=C1",3.917,5,3,7]
["S2821","RG108","e11","L3000-12","in 10mM DMSO","DNA Methyltransferase","Epigenetics","RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.",334.33,"48208-26-0",{"v":67,"d":"67.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/rg108.html","C19H14N2O4","free base","N-Phthalyl-L-tryptophan","OC(=O)C(CC1=C[NH]C2=C1C=CC=C2)N3C(=O)C4=CC=CC=C4C3=O",2.677,3,1,4]
["S2823","Tideglusib (NP031112)","f11","L3000-12","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.",334.39,"865854-05-3",{"v":8,"d":"8.00"},23.92,"<1","N/A","http://selleckchem.com/products/tideglusib.html","C19H14N2O2S","free base","NP-12","O=C1SN(C(=O)N1CC2=CC=CC=C2)C3=C4C=CC=CC4=CC=C3",{"v":4.63,"d":"4.630"},2,0,3]
["S2824","TPCA-1","g11","L3000-12","in 10mM DMSO","Apoptosis related,IκB/IKK,NF-κB,STAT","NF-κB","TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.",279.29,"507475-17-4",{"v":56,"d":"56.00"},200.51,"<1","N/A","http://selleckchem.com/products/tpca-1.html","C12H10FN3O2S","free base","GW683965","NC(=O)NC1=C(C=C(S1)C2=CC=C(F)C=C2)C(N)=O",1.544,2,3,3]
["S2825","ML133 HCl","h11","L3000-12","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.",313.82,"1222781-70-5",{"v":63,"d":"63.00"},200.75,"<1","N/A","http://selleckchem.com/products/Ml-133-hcl.html","C19H19NO.HCl","Hydrochloride","N/A","Cl.COC1=CC=C(CNCC2=CC=CC3=C2C=CC=C3)C=C1",4.225,1,1,5]
["S2840","Apalutamide (ARN-509)","a2","L3000-13","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.",477.43,"956104-40-8",{"v":18,"d":"18.00"},{"v":37.7,"d":"37.70"},"<1","N/A","http://selleckchem.com/products/arn-509.html","C21H15F4N5O2S","free base","N/A","CNC(=O)C1=CC=C(C=C1F)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C#N)C(=C4)C(F)(F)F",4.452,3,1,4]
["S2842","SAR131675","b2","L3000-13","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.",358.39,"1433953-83-3",{"v":30,"d":"30.00"},83.71,"<1","N/A","http://selleckchem.com/products/sar131675.html","C18H22N4O4","free base","N/A","CCN1C(=C(C(=O)NC)C(=O)C2=CC=C(N=C12)C#CC(C)(O)COC)N",0.769,4,2,6]
["S2843","BI-D1870","c2","L3000-13","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2845","Semaxanib (SU5416)","d2","L3000-13","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.",238.28,"204005-46-9",{"v":22,"d":"22.00"},92.33,"<1","N/A","http://selleckchem.com/products/semaxanib-su5416.html","C15H14N2O","free base","semaxinib","CC1=CC(=C([NH]1)/C=C/2C(=O)NC3=CC=CC=C23)C",2.747,1,2,1]
["S2851","Baricitinib (INCB028050)","e2","L3000-13","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.",371.42,"1187594-09-7",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/baricitinib-ly3009104.html","C16H17N7O2S","free base","LY3009104","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":0.36,"d":"0.360"},5,1,5]
["S2852","BRL-54443","f2","L3000-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.",230.31,"57477-39-1",{"v":46,"d":"46.00"},199.73,"<1","N/A","http://selleckchem.com/products/brl-54443.html","C14H18N2O","free base","N/A","CN1CCC(CC1)C2=C[NH]C3=C2C=C(O)C=C3",2.572,0,2,1]
["S2853","Carfilzomib (PR-171)","g2","L3000-13","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,Proteasome","Proteases","Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.",719.91,"868540-17-4",{"v":50,"d":"50.00"},69.45,"<1","N/A","http://selleckchem.com/products/carfilzomib-pr-171.html","C40H57N5O7","free base","N/A","CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)C4(C)CO4",3.799,7,4,20]
["S2854","BML-190","h2","L3000-13","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor.",426.89,"2854-32-2",{"v":22,"d":"22.00"},51.54,"<1","N/A","http://selleckchem.com/products/bml-190.html","C23H23ClN2O4","free base","IMMA","COC1=CC2=C(C=C1)[N](C(=C2CC(=O)N3CCOCC3)C)C(=O)C4=CC=C(Cl)C=C4",3.707,4,0,4]
["S2858","StemRegenin 1 (SR1)","a3","L3000-13","in 10mM DMSO","AhR","Metabolism","StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.",429.54,"1227633-49-9",{"v":86,"d":"86.00"},200.21,"<1","N/A","http://selleckchem.com/products/stemRegenin-1.html","C24H23N5OS","free base","N/A","CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=CC=C(O)C=C3)C4=CSC5=CC=CC=C45",{"v":5.19,"d":"5.190"},3,2,6]
["S2859","Golvatinib (E7050)","b3","L3000-13","in 10mM DMSO","c-Met,VEGFR","Protein Tyrosine Kinase","Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2.",633.69,"928037-13-2",{"v":20,"d":"20.00"},31.56,"<1","N/A","http://selleckchem.com/products/golvatinib-e7050.html","C33H37F2N7O4","free base","N/A","CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4)F",3.173,5,3,8]
["S2860","IEM 1754 2HBr","c3","L3000-13","in 10mM DMSO","GluR","Neuronal Signaling","IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.",412.25,"162831-31-4",{"v":82,"d":"82.00"},198.91,{"v":82,"d":"82.00"},198.91,"http://selleckchem.com/products/iem-1754-dihydrobromide.html","C16H30N2.2HBr","DihydrobroMide","N/A","Br.Br.NCCCCCNC[C]12C[CH]3C[CH]([CH2]C([CH2]3)C1)C2",{"v":3.51,"d":"3.510"},0,2,7]
["S2862","VU 0364770","d3","L3000-13","in 10mM DMSO","GluR","Neuronal Signaling","VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.",232.67,"61350-00-3",{"v":47,"d":"47.00"},{"v":202,"d":"202.00"},"<1","N/A","http://selleckchem.com/products/vu-0364770.html","C12H9ClN2O","free base","N/A","ClC1=CC(=CC=C1)NC(=O)C2=NC=CC=C2",2.557,2,1,2]
["S2863","Nodinitib-1","e3","L3000-13","in 10mM DMSO","NOD","NF-κB","Nodinitib-1(ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.",287.34,"799264-47-4",{"v":57,"d":"57.00"},198.37,"<1","N/A","http://selleckchem.com/products/ml130.html","C14H13N3O2S","free base","ML130","CC1=CC=C(C=C1)[S](=O)(=O)[N]2C(=NC3=CC=CC=C23)N",2.984,3,1,2]
["S2864","IMD 0354","f3","L3000-13","in 10mM DMSO","IκB/IKK","NF-κB","IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.",383.67,"978-62-1",{"v":10,"d":"10.00"},26.06,"<1","N/A","http://selleckchem.com/products/imd-0354.html","C15H8ClF6NO2","free base","IKK2 Inhibitor V","OC1=C(C=C(Cl)C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F",4.921,1,2,4]
["S2866","U-104","g3","L3000-13","in 10mM DMSO","Carbonic Anhydrase","Metabolism","U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.",309.32,"178606-66-1",{"v":62,"d":"62.00"},200.44,"<1","N/A","http://selleckchem.com/products/u-104.html","C13H12FN3O3S","free base","MST-104, NSC 213841, SLC-0111, WBI-5111","N[S](=O)(=O)C1=CC=C(NC(=O)NC2=CC=C(F)C=C2)C=C1",1.433,3,3,3]
["S2867","WHI-P154","h3","L3000-13","in 10mM DMSO","EGFR,JAK","JAK/STAT","WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.",{"v":376.2,"d":"376.20"},"211555-04-3",{"v":75,"d":"75.00"},199.36,"<1","N/A","http://selleckchem.com/products/whi-p154.html","C16H14BrN3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC=C(O)C(=C3)Br",{"v":3.95,"d":"3.950"},4,2,4]
["S2868","Alogliptin (SYR-322) benzoate","a4","L3000-13","in 10mM DMSO","DPP","Proteases","Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.",461.51,"850649-62-6",{"v":68,"d":"68.00"},147.34,{"v":2,"d":"2.00"},4.33,"http://selleckchem.com/products/alogliptin-syr-322.html","C18H21N5O2.C7H6O2","benzoate","SYR-322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S2871","T0070907","b4","L3000-13","in 10mM DMSO","DNA-PK,PPAR,RAD51","DNA Damage/DNA Repair","T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM in a cell-free assay, with a >800-fold selectivity over PPARα and PPARδ. T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.",277.66,"313516-66-4",{"v":26,"d":"26.00"},93.64,"<1","N/A","http://selleckchem.com/products/t0070907.html","C12H8ClN3O3","free base","N/A","[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC2=CC=NC=C2",2.022,2,1,3]
["S2872","GW5074","c4","L3000-13","in 10mM DMSO","Apoptosis related,Raf","MAPK","GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted. GW5074 inhibits LK-induced apoptosis.",520.94,"220904-83-6",{"v":104,"d":"104.00"},199.64,"<1","N/A","http://selleckchem.com/products/gw5074.html","C15H8Br2INO2","free base","N/A","OC1=C(Br)C=C(C=C1Br)C=C2C(=O)NC3=CC=C(I)C=C23",4.564,1,2,1]
["S2874","Camostat Mesilate","d4","L3000-13","in 10mM DMSO","COVID-19,Sodium Channel","Transmembrane Transporters","Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.",494.52,"59721-29-8",{"v":99,"d":"99.00"},200.19,{"v":10,"d":"10.00"},20.22,"http://selleckchem.com/products/camostat-mesilate-foy-305.html","C20H22N4O5.CH4O3S","Mesilate","FOY-305, FOY-S980","CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1.C[S](O)(=O)=O",0.969,5,2,10]
["S2875","Prucalopride","e4","L3000-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Prucalopride (R-93877) is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.",367.87,"179474-81-8",{"v":60,"d":"60.00"},{"v":163.1,"d":"163.10"},"<1","N/A","http://selleckchem.com/products/prucalopride.html","C18H26ClN3O3","Free Base","R-93877","COCCCN1CCC(CC1)NC(=O)C2=CC(=C(N)C3=C2OCC3)Cl",1.056,3,2,6]
["S2882","IKK-16 (IKK Inhibitor VII)","f4","L3000-13","in 10mM DMSO","IκB/IKK,LRRK2","NF-κB","IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.",483.63,"873225-46-8",{"v":97,"d":"97.00"},200.57,"<1","N/A","http://selleckchem.com/products/ikk-16.html","C28H29N5OS","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC=C(NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5)C=C3",5.208,3,1,5]
["S2883","4-Aminohippuric Acid","g4","L3000-13","in 10mM DMSO","Others","Others","4-Aminohippuric acid is a typical substrate of organic anion transport systems.",194.19,"61-78-9",{"v":39,"d":"39.00"},200.83,{"v":3,"d":"3.00"},15.45,"http://selleckchem.com/products/4-aminohippuric-acid.html","C9H10N2O3","free base","N/A","NC1=CC=C(C=C1)C(=O)NCC(O)=O",-0.227,2,2,3]
["S2884","Acesulfame Potassium","h4","L3000-13","in 10mM DMSO","Others","Others","Acesulfame potassium is a non-nutritive sweetener.",202.25,"55589-62-3",{"v":40,"d":"40.00"},197.78,{"v":40,"d":"40.00"},197.78,"http://selleckchem.com/products/acesulfame-potassium.html","C4H5NO4S.K","Potassium Salt","N/A","[KH].CC1=CC(=O)N[S](=O)(=O)O1",-0.858,2,1,0]
["S2885","A-205804","a5","L3000-13","in 10mM DMSO","Integrin","Cytoskeletal Signaling","A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.",{"v":300.4,"d":"300.40"},"251992-66-2",{"v":60,"d":"60.00"},199.73,"<1","N/A","http://selleckchem.com/products/a-205804.html","C15H12N2OS2","free base","N/A","CC1=CC=C(SC2=CN=CC3=C2C=C(S3)C(N)=O)C=C1",3.439,2,1,3]
["S2890","PF-562271","b5","L3000-13","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.",507.49,"717907-75-0",{"v":100,"d":"100.00"},197.05,"<1","N/A","http://selleckchem.com/products/pf-562271.html","C21H20F3N7O3S","free base","PF-00562271","CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O",2.491,6,3,8]
["S2891","GW441756","c5","L3000-13","in 10mM DMSO","Apoptosis related,Caspase,Trk receptor","Protein Tyrosine Kinase","GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis.",{"v":275.3,"d":"275.30"},"504433-23-2",{"v":25,"d":"25.00"},90.81,"<1","N/A","http://selleckchem.com/products/gw-441756.html","C17H13N3O","free base","N/A","C[N]1C=C(C=C2C(=O)NC3=CC=CN=C23)C4=C1C=CC=C4",2.508,2,1,1]
["S2892","VU 0361737","d5","L3000-13","in 10mM DMSO","GluR","Neuronal Signaling","VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.",262.69,"1161205-04-4",{"v":53,"d":"53.00"},201.76,"<1","N/A","http://selleckchem.com/products/vu-0361737.html","C13H11ClN2O2","free base","N/A","COC1=CC(=CC=C1Cl)NC(=O)C2=NC=CC=C2",{"v":2.54,"d":"2.540"},3,1,3]
["S2894","SB742457","e5","L3000-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.",353.44,"607742-69-8",{"v":78,"d":"78.00"},220.69,"<1","N/A","http://selleckchem.com/products/sb-742457.html","C19H19N3O2S","free base","GSK 742457","O=[S](=O)(C1=CC=CC=C1)C2=CC3=C(N=C2)C(=CC=C3)N4CCNCC4",2.702,3,1,3]
["S2895","Tyrphostin 9","f5","L3000-13","in 10mM DMSO","EGFR,PDGFR","Protein Tyrosine Kinase","Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.",282.38,"10537-47-0",{"v":56,"d":"56.00"},198.31,"<1","N/A","http://selleckchem.com/products/tyrphostin-9-sf-6847.html","C18H22N2O","free base","SF 6847, RG-50872","CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N",4.574,0,1,3]
["S2896","ZM 323881 HCl","g5","L3000-13","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","ZM 323881 is a potent and selective VEGFR2 inhibitor with IC50 of <2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2.",411.86,"193000-39-4",{"v":10,"d":"10.00"},24.28,"<1","N/A","http://selleckchem.com/products/zm-323881-hcl.html","C22H18FN3O2.HCl","Hydrochloride","N/A","Cl.CC1=CC(=C(NC2=C3C=CC(=CC3=NC=N2)OCC4=CC=CC=C4)C=C1O)F",5.876,3,2,5]
["S2897","ZM 306416","h5","L3000-13","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","ZM 306416 (CB 676475) is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.",333.74,"690206-97-4",{"v":67,"d":"67.00"},200.76,"<1","N/A","http://selleckchem.com/products/zm-306416.html","C16H13ClFN3O2","free base","CB 676475","COC1=CC2=NC=NC(=C2C=C1OC)NC3=C(F)C=C(Cl)C=C3",4.314,4,1,4]
["S2898","MLN0905","a6","L3000-13","in 10mM DMSO","PLK","Cell Cycle","MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.",486.56,"1228960-69-7",{"v":97,"d":"97.00"},199.36,"<1","N/A","http://selleckchem.com/products/mln0905.html","C24H25F3N6S","free base","N/A","CN(C)CCCC1=CC(=C(C)N=C1)NC2=NC3=C(CC(=S)NC4=CC(=CC=C34)C(F)(F)F)C=N2",5.355,3,2,7]
["S2899","GNF-2","b6","L3000-13","in 10mM DMSO","Bcr-Abl","Angiogenesis","GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells.",374.32,"778270-11-4",{"v":74,"d":"74.00"},197.69,"<1","N/A","http://selleckchem.com/products/gnf-2.html","C18H13F3N4O2","free base","N/A","NC(=O)C1=CC=CC(=C1)C2=NC=NC(=C2)NC3=CC=C(OC(F)(F)F)C=C3",5.209,4,2,6]
["S2900","Cobicistat (GS-9350)","c6","L3000-13","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.",776.02,"1004316-88-4",{"v":100,"d":"100.00"},128.86,"<1","N/A","http://selleckchem.com/products/cobicistat-gs-9350.html","C40H53N7O5S2","free base","N/A","CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5",4.765,7,3,20]
["S2901","CCG 50014","d6","L3000-13","in 10mM DMSO","RGS","GPCR & G Protein","CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.",316.35,"883050-24-6",{"v":63,"d":"63.00"},199.15,"<1","N/A","http://selleckchem.com/products/ccg-50014.html","C16H13FN2O2S","free base","N/A","CC1=CC=C(C=C1)N2SC(=O)N(CC3=CC=C(F)C=C3)C2=O",4.414,2,0,3]
["S2902","S-Ruxolitinib (INCB018424)","e6","L3000-13","in 10mM DMSO","JAK","JAK/STAT","S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.",306.37,"941685-37-6",{"v":61,"d":"61.00"},199.11,{"v":5,"d":"5.00"},16.32,"http://selleckchem.com/products/s-ruxolitinib.html","C17H18N6","free base","N/A","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S2904","PF-477736","f6","L3000-13","in 10mM DMSO","Chk","Cell Cycle","PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.",419.48,"952021-60-2",{"v":6,"d":"6.00"},{"v":14.3,"d":"14.30"},"<1","N/A","http://selleckchem.com/products/pf-477736.html","C22H25N7O2","free base","PF-736, PF-00477736","C[N]1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(N)C5CCCCC5)[NH]2",2.089,4,4,4]
["S2905","JNJ-7777120","g6","L3000-13","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.",277.75,"459168-41-3",{"v":56,"d":"56.00"},201.62,"<1","N/A","http://selleckchem.com/products/jnj-7777120.html","C14H16ClN3O","free base","N/A","CN1CCN(CC1)C(=O)C2=CC3=CC(=CC=C3[NH]2)Cl",{"v":2.45,"d":"2.450"},1,1,1]
["S2906","Ki16198","h6","L3000-13","in 10mM DMSO","LPA Receptor","GPCR & G Protein","Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.",488.98,"355025-13-7",{"v":96,"d":"96.00"},196.33,"<1","N/A","http://selleckchem.com/products/ki16198.html","C24H25ClN2O5S","free base","N/A","COC(=O)CCSCC1=CC=C(C=C1)C2=C(NC(=O)OC(C)C3=C(Cl)C=CC=C3)C(=NO2)C",5.269,6,1,11]
["S2907","Pirfenidone (S-7701)","a7","L3000-13","in 10mM DMSO","CCR,TGF-beta/Smad","TGF-beta/Smad","Pirfenidone (S-7701, AMR-69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.",185.22,"53179-13-8",{"v":37,"d":"37.00"},199.76,"<1","N/A","http://selleckchem.com/products/pirfenidone.html","C12H11NO","free base","AMR-69","CC1=CN(C(=O)C=C1)C2=CC=CC=C2",1.905,1,0,1]
["S2910","Tempol","b7","L3000-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.",172.24,"2226-96-2",{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},"http://selleckchem.com/products/tempol-4-hydroxy-tempo.html","C9H18NO2","free base","4-Hydroxy-TEMPO","CC1(C)CC(O)CC(C)(C)N1[O]",0.413,0,1,0]
["S2911","Go 6983","c7","L3000-13","in 10mM DMSO","PKC","TGF-beta/Smad","Go 6983 (GOE 6983, Gö 6983) is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.",442.51,"133053-19-7",{"v":59,"d":"59.00"},133.33,"<1","N/A","http://selleckchem.com/products/go-6983.html","C26H26N4O3","free base","GOE 6983, Gö 6983","COC1=CC=C2[N](CCCN(C)C)C=C(C2=C1)C3=C(C(=O)NC3=O)C4=C[NH]C5=C4C=CC=C5",{"v":3.54,"d":"3.540"},3,2,7]
["S2912","WZ811","d7","L3000-13","in 10mM DMSO","CXCR","GPCR & G Protein","WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.",290.36,"55778-02-4",{"v":30,"d":"30.00"},103.32,"<1","N/A","http://selleckchem.com/products/wz-811.html","C18H18N4","free base","N/A","C(NC1=NC=CC=C1)C2=CC=C(CNC3=NC=CC=C3)C=C2",3.391,2,2,6]
["S2913","BAY 11-7082","e7","L3000-13","in 10mM DMSO","Apoptosis related,DUB,IκB/IKK","NF-κB","BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.",207.25,"19542-67-7",{"v":41,"d":"41.00"},197.83,"<1","N/A","http://selleckchem.com/products/bay-11-7082-bay-11-7821.html","C10H9NO2S","free base","BAY 11-7821","CC1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",1.721,2,0,2]
["S2914","Dapivirine (TMC120)","f7","L3000-13","in 10mM DMSO","Reverse Transcriptase","Microbiology","Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.",{"v":329.4,"d":"329.40"},"244767-67-7",{"v":34,"d":"34.00"},103.22,"<1","N/A","http://selleckchem.com/products/dapivirine.html","C20H19N5","free base","N/A","CC1=CC(=C(NC2=CC=NC(=N2)NC3=CC=C(C=C3)C#N)C(=C1)C)C",5.549,2,2,4]
["S2915","GW9662","g7","L3000-13","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM in a cell-free assay, with at least 10- to 600-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.",276.68,"22978-25-2",{"v":55,"d":"55.00"},198.79,"<1","N/A","http://selleckchem.com/products/gw9662.html","C13H9ClN2O3","free base","TIMTEC-BB SBB006523","[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC2=CC=CC=C2",3.173,1,1,3]
["S2916","ML161 (Parmodulin 2)","h7","L3000-13","in 10mM DMSO","PAR","GPCR & G Protein","ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.",361.23,"423735-93-7",{"v":72,"d":"72.00"},199.32,"<1","N/A","http://selleckchem.com/products/ml-161.html","C17H17BrN2O2","free base","N/A","CCCC(=O)NC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2Br",3.606,2,2,5]
["S2919","IOX2","a8","L3000-13","in 10mM DMSO","HIF","Angiogenesis","IOX2 (JICL38) is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.",352.34,"931398-72-0",{"v":7,"d":"7.00"},19.87,"<1","N/A","http://selleckchem.com/products/iox2.html","C19H16N2O5","free base","JICL38","OC(=O)CNC(=O)C1=C(O)C2=C(C=CC=C2)N(CC3=CC=CC=C3)C1=O",1.153,3,2,5]
["S2921","PF-4981517","b8","L3000-13","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","PF-4981517 (CYP3cide, PF-04981517) is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7.",456.59,"1390637-82-7",{"v":91,"d":"91.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/pf-4981517.html","C26H32N8","free base","CYP3cide, PF-04981517","C[N]1N=CC(=C1C2=CC=C(C)C=C2)C3=N[N](C)C4=NC=NC(=C34)N5CCC(C5)N6CCCCC6",4.659,4,0,4]
["S2922","Icotinib (BPI-2009H)","c8","L3000-13","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Icotinib (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).",391.42,"610798-31-7",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/icotinib.html","C22H21N3O4","free base","BPI-2009H","C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C4OCCOCCOCCOC4=C3",4.128,6,1,2]
["S2923","Salubrinal","d8","L3000-13","in 10mM DMSO","eIF,PERK","Apoptosis","Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.",479.81,"405060-95-9",{"v":95,"d":"95.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/salubrinal.html","C21H17Cl3N4OS","free base","N/A","ClC(Cl)(Cl)C(NC(=O)\\C=C\\C1=CC=CC=C1)NC(=S)NC2=CC=CC3=C2N=CC=C3",{"v":5.82,"d":"5.820"},2,3,8]
["S2924","Laduviglusib (CHIR-99021) HCl","e8","L3000-13","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.",{"v":501.8,"d":"501.80"},"1797989-42-4",{"v":93,"d":"93.00"},185.33,"<1","N/A","http://selleckchem.com/products/chir-99021-ct99021-hcl.html","C22H18Cl2N8.HCl","Hydrochloride","CT99021 HCl","Cl.CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=NC=C(C=C3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.858,4,3,7]
["S2925","Evacetrapib (LY2484595)","f8","L3000-13","in 10mM DMSO","CETP","Metabolism","Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.",638.65,"1186486-62-3",{"v":12.8,"d":"12.80"},20.04,"<1","N/A","http://selleckchem.com/products/evacetrapib-ly2484595.html","C31H36F6N6O2","free base","N/A","C[N]1N=NC(=N1)N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3CCCN(CC4CCC(CC4)C(O)=O)C5=C3C=C(C)C=C5C",8.617,4,0,9]
["S2926","TDZD-8","g8","L3000-13","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.",222.26,"327036-89-5",{"v":44.5,"d":"44.50"},200.22,"<1","N/A","http://selleckchem.com/products/tdzd-8.html","C10H10N2O2S","free base","NP 01139","CN1SC(=O)N(CC2=CC=CC=C2)C1=O",2.145,2,0,2]
["S2927","Apoptosis Activator 2","h8","L3000-13","in 10mM DMSO","Caspase","Apoptosis","Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.",306.14,"79183-19-0",{"v":61,"d":"61.00"},199.26,"<1","N/A","http://selleckchem.com/products/apoptosis-activator-2.html","C15H9Cl2NO2","free base","N/A","ClC1=C(Cl)C=C(CN2C(=O)C(=O)C3=C2C=CC=C3)C=C1",3.788,2,0,2]
["S2928","TAK-715","a9","L3000-13","in 10mM DMSO","p38 MAPK","MAPK","TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.",399.51,"303162-79-0",{"v":80,"d":"80.00"},200.25,"<1","N/A","http://selleckchem.com/products/tak-715.html","C24H21N3OS","free base","N/A","CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C",5.629,3,1,5]
["S2929","Pifithrin-α (PFTα) HBr","b9","L3000-13","in 10mM DMSO","AhR,Autophagy,p53","Apoptosis","Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).",{"v":367.3,"d":"367.30"},"63208-82-2",{"v":67,"d":"67.00"},182.41,"<1","N/A","http://selleckchem.com/products/pifithrin-alpha.html","C16H18N2OS.HBr","HBr","Pifithrin-α hydrobromide","Br.CC1=CC=C(C=C1)C(=O)CN2C(=N)SC3=C2CCCC3",3.993,1,0,3]
["S2930","Pifithrin-μ","c9","L3000-13","in 10mM DMSO","Autophagy,HSP (HSP90),p53","Apoptosis","Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.",181.21,"64984-31-2",{"v":36,"d":"36.00"},198.66,"<1","N/A","http://selleckchem.com/products/pifithrin-u.html","C8H7NO2S","free base","NSC 303580, PFTμ, 2-Phenylethynesulfonamide","N[S](=O)(=O)C#CC1=CC=CC=C1",0.825,2,1,2]
["S3001","Clevudine","d9","L3000-13","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.",260.22,"163252-36-6",{"v":52,"d":"52.00"},199.83,{"v":52,"d":"52.00"},199.83,"http://selleckchem.com/products/clevudine-levovir.html","C10H13FN2O5","free base","Levovir,L-FMAU","CC1=CN(C2OC(CO)C(O)C2F)C(=O)NC1=O",-1.065,3,3,2]
["S3002","Rivaroxaban (BAY 59-7939)","e9","L3000-13","in 10mM DMSO","Factor Xa","Metabolism","Rivaroxaban (BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).",435.88,"366789-02-8",{"v":87,"d":"87.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/Rivaroxaban.html","C19H18ClN3O5S","free base","BAY 59-7939","ClC1=CC=C(S1)C(=O)NCC2CN(C(=O)O2)C3=CC=C(C=C3)N4CCOCC4=O",1.797,5,1,5]
["S3005","Paroxetine HCl","f9","L3000-13","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.",365.83,"78246-49-8",{"v":73,"d":"73.00"},199.55,{"v":1,"d":"1.00"},2.73,"http://selleckchem.com/products/paroxetine-hcl.html","C19H20FNO3.HCl","Hydrochloride","BRL-29060A, FG-7051","Cl.FC1=CC=C(C=C1)C2CCNCC2COC3=CC4=C(OCO4)C=C3",3.611,3,1,4]
["S3008","Zaltoprofen","g9","L3000-13","in 10mM DMSO","COX","Neuronal Signaling","Zaltoprofen(CN100,Soleton) is an inhibitor of COX-1 and COX-2 for treatment of arthritis.",298.36,"74711-43-6",{"v":60,"d":"60.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://selleckchem.com/products/zaltoprofen.html","C17H14O3S","free base","CN100,Soleton","CC(C(O)=O)C1=CC2=C(SC3=CC=CC=C3C(=O)C2)C=C1",3.684,2,0,2]
["S3012","Pazopanib","h9","L3000-13","in 10mM DMSO","Autophagy,Cathepsin B,c-Kit,CSF-1R,Cysteine Protease,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.",437.52,"444731-52-6",{"v":87,"d":"87.00"},198.85,"<1","N/A","http://selleckchem.com/products/pazopanib.html","C21H23N7O2S","Free Base","GW786034","C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",3.741,5,2,5]
["S3015","Amoxicillin","a10","L3000-13","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.",{"v":365.4,"d":"365.40"},"26787-78-0",{"v":73,"d":"73.00"},199.78,"<1","N/A","http://selleckchem.com/products/amoxicillin-amoxycillin.html","C16H19N3O5S","Free Base","Amoxycillin","CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O",-2.539,3,3,4]
["S3017","Aspirin (NSC 27223)","b10","L3000-13","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3018","Niflumic acid","c10","L3000-13","in 10mM DMSO","COX,GABA Receptor","Neuronal Signaling","Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.",282.22,"4394-00-7",{"v":56,"d":"56.00"},198.43,"<1","N/A","http://selleckchem.com/products/niflumic-acid.html","C13H9F3N2O2","free base","Nifluril","OC(=O)C1=CC=CN=C1NC2=CC=CC(=C2)C(F)(F)F",{"v":3.34,"d":"3.340"},2,1,4]
["S3019","Ciclopirox ethanolamine","d10","L3000-13","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator.",268.35,"41621-49-2",{"v":6,"d":"6.00"},22.36,"<1","N/A","http://selleckchem.com/products/ciclopirox-ethanolamine.html","C12H17NO2.C2H7NO","Ethanolamine","Ciclopirox olamine, HOE 296,Ciclopiroxolamine","CC1=CC(=O)N(O)C(=C1)C2CCCCC2.NCCO",1.302,1,2,2]
["S3021","Rimonabant (SR141716)","e10","L3000-13","in 10mM DMSO","Acyltransferase,Bacterial,Cannabinoid Receptor,MmpL3,Transferase","GPCR & G Protein","Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.",463.79,"168273-06-1",{"v":25,"d":"25.00"},{"v":53.9,"d":"53.90"},"<1","N/A","http://selleckchem.com/products/rimonabant-sr141716.html","C22H21Cl3N4O","free base","SR141716","CC1=C([N](N=C1C(=O)NN2CCCCC2)C3=CC=C(Cl)C=C3Cl)C4=CC=C(Cl)C=C4",6.613,2,1,4]
["S3022","Cabazitaxel (XRP6258)","f10","L3000-13","in 10mM DMSO","Autophagy,Microtubule Associated","Cytoskeletal Signaling","Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.",835.93,"183133-96-2",{"v":100,"d":"100.00"},119.63,"<1","N/A","http://selleckchem.com/products/cabazitaxel-jevtana.html","C45H57NO14","free base","RPR-116258A, TXD 258, Taxoid XRP6258","COC1CC2OCC2(OC(C)=O)C3C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(OC)C(=O)C13C)C5(C)C)C",3.403,12,2,15]
["S3023","Bufexamac","g10","L3000-13","in 10mM DMSO","COX,IFN","Neuronal Signaling","Bufexamac(Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.",223.27,"2438-72-4",{"v":45,"d":"45.00"},201.55,"<1","N/A","http://selleckchem.com/products/bufexamac.html","C12H17NO3","free base","Bufexamic acid","CCCCOC1=CC=C(CC(=O)NO)C=C1",2.191,2,1,6]
["S3024","Lamotrigine","h10","L3000-13","in 10mM DMSO","5-HT Receptor,Sodium Channel","Transmembrane Transporters","Lamotrigine (BW-430C,LTG) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.",256.09,"84057-84-1",{"v":10,"d":"10.00"},39.05,"<1","N/A","http://selleckchem.com/products/lamotrigine.html","C9H7Cl2N5","free base","BW-430C,LTG","NC1=NC(=C(N=N1)C2=CC=CC(=C2Cl)Cl)N",2.426,3,2,1]
["S3025","PMSF","a11","L3000-13","in 10mM DMSO","Cysteine Protease,Serine Protease","Proteases","PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.",174.19,"329-98-6",{"v":35,"d":"35.00"},200.93,"<1","N/A","http://selleckchem.com/products/pmsf-phenylmethylsulfonyl-fluoride.html","C7H7FO2S","free base","Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride","F[S](=O)(=O)CC1=CC=CC=C1",1.459,2,0,2]
["S3026","Piceatannol","b11","L3000-13","in 10mM DMSO","Arginase,Syk","Angiogenesis","Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.",244.24,"10083-24-6",{"v":48,"d":"48.00"},196.53,"<1","N/A","http://selleckchem.com/products/piceatannol.html","C14H12O4","free base","N/A","OC1=CC(=CC(=C1)/C=C/C2=CC=C(O)C(=C2)O)O",2.848,0,4,2]
["S3027","Fenoprofen calcium hydrate","c11","L3000-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).",558.63,"71720-56-4, 53746-45-5",{"v":48,"d":"48.00"},85.92,"<1","N/A","http://selleckchem.com/products/fenoprofen-calcium-hydrate.html","C30H30CaO8","Calcium dihydrate salt","Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate","O.O.CC(C(=O)O[Ca]OC(=O)C(C)C1=CC=CC(=C1)OC2=CC=CC=C2)C3=CC=CC(=C3)OC4=CC=CC=C4",6.802,6,0,12]
["S3030","Niclosamide (BAY2353)","d11","L3000-13","in 10mM DMSO","Autophagy,STAT","JAK/STAT","Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).",327.12,"50-65-7",{"v":8,"d":"8.00"},24.46,"<1","N/A","http://www.selleck.cn/products/niclosamide-niclocide.html","C13H8Cl2N2O4","Free Base","Niclocide, NSC 178296","OC1=CC=C(Cl)C=C1C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.595,1,2,3]
["S3032","Bindarit (AF 2838)","e11","L3000-13","in 10mM DMSO","CCR,Immunology & Inflammation related","Immunology & Inflammation","Bindarit (AF 2838) exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.",324.37,"130641-38-2",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/bindarit.html","C19H20N2O3","free base","AF 2838","CC(C)(OCC1=N[N](CC2=CC=CC=C2)C3=C1C=CC=C3)C(O)=O",3.559,3,0,6]
["S3035","Daunorubicin (RP 13057) HCl","f11","L3000-13","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,COVID-19,DNA/RNA Synthesis,Topoisomerase","DNA Damage/DNA Repair","Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.",563.98,"23541-50-6",{"v":100,"d":"100.00"},177.31,{"v":100,"d":"100.00"},177.31,"http://selleckchem.com/products/daunorubicin-hcl-daunomycin-hcl.html","C27H29NO10.HCl","Hydrochloride","Daunomycin HCl, Rubidomycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(C)=O)O)C(=O)C2=CC=C1",{"v":1.01,"d":"1.010"},6,4,4]
["S3036","Pravastatin sodium","g11","L3000-13","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.",446.51,"81131-70-6",{"v":89,"d":"89.00"},199.32,{"v":89,"d":"89.00"},199.32,"http://selleckchem.com/products/pravastatin-pravachol.html","C23H35O7.Na","sodium","CS-514 Sodium","[Na+].CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC([O-])=O)C12",0.682,2,3,11]
["S3037","Bepotastine Besilate","h11","L3000-13","in 10mM DMSO","COVID-19,Histamine Receptor","Neuronal Signaling","Bepotastine Besilate (TAU 284) is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.",547.06,"190786-44-8",{"v":109,"d":"109.00"},199.25,"<1","N/A","http://selleckchem.com/products/bepotastine-besilate.html","C21H25ClN2O3.C6H6O3S","Besilate salt","TAU 284","OC(=O)CCCN1CCC(CC1)OC(C2=CC=C(Cl)C=C2)C3=NC=CC=C3.O[S](=O)(=O)C4=CC=CC=C4",1.371,3,0,9]
["S3043","Rofecoxib","a2","L3000-14","in 10mM DMSO","COX","Neuronal Signaling","Rofecoxib (MK-0966) is a COX-2 inhibitor with IC50 of 18 nM.",314.36,"162011-90-7",{"v":63,"d":"63.00"},200.41,"<1","N/A","http://selleckchem.com/products/rofecoxib-vioxx.html","C17H14O4S","free base","MK-0966","C[S](=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3",2.871,4,0,3]
["S3046","Azilsartan","b2","L3000-14","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.",456.45,"147403-03-0",{"v":91,"d":"91.00"},199.36,"<1","N/A","http://selleckchem.com/products/azilsartan-tak-536.html","C25H20N4O5","free base","TAK-536","CCOC1=NC2=CC=CC(=C2[N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(O)=O",4.662,6,1,7]
["S3047","Otilonium Bromide","c2","L3000-14","in 10mM DMSO","AChR","Neuronal Signaling","Otilonium bromide is an antimuscarinic.",563.57,"26095-59-0",{"v":113,"d":"113.00"},200.51,{"v":113,"d":"113.00"},200.51,"http://selleckchem.com/products/otilonium-bromide.html","C29H43BrN2O4","quaternary-N bromide salt","N/A","[Br-].CCCCCCCCOC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)OCC[N+](C)(CC)CC",{"v":2.67,"d":"2.670"},4,1,17]
["S3052","Rupatadine Fumarate","d2","L3000-14","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively.",532.03,"182349-12-8",{"v":9,"d":"9.00"},16.92,"<1","N/A","http://selleckchem.com/products/rupatadine-fumarate.html","C26H26ClN3.C4H4O4","Fumarate","N/A","CC1=CN=CC(=C1)CN2CCC(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C35.OC(=O)\\C=C\\C(O)=O",2.672,4,0,4]
["S3054","Alverine Citrate","e2","L3000-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.",473.56,"5560-59-8",{"v":95,"d":"95.00"},200.61,"<1","N/A","http://selleckchem.com/products/alverine-citrate.html","C20H27N.C6H8O7","Citrate","NSC 35459","CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.037,3,0,14]
["S3057","Azilsartan Medoxomil","f2","L3000-14","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.",568.53,"863031-21-4",{"v":114,"d":"114.00"},200.52,"<1","N/A","http://selleckchem.com/products/azilsartan-medoxomil-tak-491.html","C30H24N4O8","free base","TAK-491","CCOC1=NC2=CC=CC(=C2[N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)OCC6=C(C)OC(=O)O6",{"v":5.27,"d":"5.270"},10,1,10]
["S3067","Chlorhexidine 2HCl","g2","L3000-14","in 10mM DMSO","Anti-infection","Microbiology","Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.",578.37,"3697-42-5",{"v":100,"d":"100.00"},{"v":172.9,"d":"172.90"},"<1","N/A","http://selleckchem.com/products/chlorhexidine-hcl.html","C22H30Cl2N10.2HCl","HCl","NSC-185","Cl.Cl.ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1",5.137,0,6,17]
["S3078","Beclomethasone dipropionate","h2","L3000-14","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Beclomethasone dipropionate(Beclovent,Beconase,Vancenase)  is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.",521.04,"5534-09-8",{"v":104,"d":"104.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/beclomethasone-dipropionate.html","C28H37ClO7","free base","Beclometasone dipropionate,Beclovent,Beconase,Vancenase","CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC12C",4.064,6,1,8]
["S3079","Atovaquone","a3","L3000-14","in 10mM DMSO","COVID-19,Fungal,Parasite","Microbiology","Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.",366.84,"95233-18-4",{"v":5,"d":"5.00"},13.63,"<1","N/A","http://selleckchem.com/products/atovaquone-atavaquone.html","C22H19ClO3","free base","Atavaquone","OC1=C(C2CCC(CC2)C3=CC=C(Cl)C=C3)C(=O)C4=C(C=CC=C4)C1=O",5.319,2,1,2]
["S3080","Etravirine (TMC125)","b3","L3000-14","in 10mM DMSO","Reverse Transcriptase","Microbiology","Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.",435.28,"269055-15-4",{"v":42,"d":"42.00"},96.49,"<1","N/A","http://selleckchem.com/products/etravirine-tmc125.html","C20H15BrN6O","free base","R-165335","CC1=CC(=CC(=C1OC2=C(Br)C(=NC(=N2)NC3=CC=C(C=C3)C#N)N)C)C#N",5.492,3,2,4]
["S3081","Ulipristal Acetate (CDB 2914)","c3","L3000-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.",475.62,"126784-99-4",{"v":83,"d":"83.00"},191.43,"<1","N/A","http://selleckchem.com/products/ulipristal.html","C30H37NO4","free base","HRP 2000, RU 44675","CN(C)C1=CC=C(C=C1)C2CC3(C)C(CCC3(OC(C)=O)C(C)=O)C4CCC5=CC(=O)CCC5=C24",4.309,2,0,3]
["S3083","Indacaterol Maleate","d3","L3000-14","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.",508.56,"753498-25-8",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/indacaterol-maleate.html","C24H28N2O3.C4H4O4","Maleate","QAB149","CCC1=CC2=C(CC(C2)NCC(O)C3=CC=C(O)C4=C3C=CC(=O)N4)C=C1CC.OC(=O)\\C=C/C(O)=O",1.264,3,4,8]
["S3100","2-Thiouracil","e3","L3000-14","in 10mM DMSO","Hydroxylase","Neuronal Signaling","2-Thiouracil(Deracil,Thiouracil) is a thiolated uracil derivative that is a known antihyperthyroid agent.",128.15,"141-90-2",{"v":26,"d":"26.00"},202.89,"<1","N/A","http://selleckchem.com/products/2-thiouracil.html","C4H4N2OS","free base","Deracil,Thiouracil","O=C1NC(=S)NC=C1",0.081,1,2,0]
["S3104","Moguisteine","f3","L3000-14","in 10mM DMSO","Others","Others","Moguisteine(BBR-2173) is a novel peripheral non-narcotic antitussive drug.",339.41,"119637-67-1",{"v":68,"d":"68.00"},200.35,"<1","N/A","http://selleckchem.com/products/moguisteine.html","C16H21NO5S","free base","BBR-2173","CCOC(=O)CC(=O)N1CCSC1COC2=CC=CC=C2OC",2.212,5,0,8]
["S3105","Nadifloxacin","g3","L3000-14","in 10mM DMSO","Antibiotics","Microbiology","Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.",360.38,"124858-35-1",{"v":20,"d":"20.00"},{"v":55.5,"d":"55.50"},"<1","N/A","http://selleckchem.com/products/nadifloxacin.html","C19H21FN2O4","free base","OPC-7251","CC1CCC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCC(O)CC4)F",1.865,2,1,2]
["S3116","Sulfathiazole","h3","L3000-14","in 10mM DMSO","Anti-infection","Microbiology","Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.",255.32,"72-14-0",{"v":51,"d":"51.00"},199.75,"<1","N/A","http://selleckchem.com/products/sulfathiazole.html","C9H9N3O2S2","free base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CS2",0.568,3,2,3]
["S3117","Oxybutynin hydrochloride","a4","L3000-14","in 10mM DMSO","AChR","Neuronal Signaling","Oxybutynin(MJ4309-1) is an anticholinergic medication used to relieve urinary and bladder difficulties.",393.95,"1508-65-2",{"v":79,"d":"79.00"},200.53,{"v":4,"d":"4.00"},10.15,"https://www.selleckchem.com/products/oxybutynin-hydrochloride.html","C22H31NO3.HCl","hydrochloride","MJ4309-1","Cl.CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C2=CC=CC=C2",5.028,2,0,10]
["S3120","Doxepin HCl","b4","L3000-14","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo.",315.84,"1229-29-4",{"v":63,"d":"63.00"},199.47,{"v":63,"d":"63.00"},199.47,"http://selleckchem.com/products/doxepin-hydrochloride-sinequan.html","C19H21NO.HCl","hydrochloride","N/A","Cl.CN(C)CC\\C=C1/C2=CC=CC=C2COC3=C1C=CC=C3",{"v":4.29,"d":"4.290"},1,0,3]
["S3124","Dexamethasone Acetate","c4","L3000-14","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3129","Trimethoprim","d4","L3000-14","in 10mM DMSO","Antibiotics,Bacterial,DHFR","Microbiology","Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.",290.32,"738-70-5",{"v":58,"d":"58.00"},199.78,"<1","N/A","http://selleckchem.com/products/trimethoprim.html","C14H18N4O3","free base","BW 56-72, NIH 204, NSC-106568","COC1=C(OC)C(=CC(=C1)CC2=CN=C(N)N=C2N)OC",1.543,5,2,5]
["S3132","Sulfamerazine","e4","L3000-14","in 10mM DMSO","Bacterial","Microbiology","Sulfamerazine (RP 2632,sulphamerazine) is a sulfonamide antibacterial.",{"v":264.3,"d":"264.30"},"127-79-7",{"v":53,"d":"53.00"},200.53,"<1","N/A","http://selleckchem.com/products/sulfamerazine.html","C11H12N4O2S","free base","RP 2632,sulphamerazine","CC1=NC(=NC=C1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.595,4,2,3]
["S3137","Sodium salicylate","f4","L3000-14","in 10mM DMSO","NF-κB","NF-κB","Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.",161.11,"54-21-7",{"v":32,"d":"32.00"},198.62,{"v":32,"d":"32.00"},198.62,"http://selleckchem.com/products/sodium-salicylate.html","C7H6O3.Na","sodium salt","2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt","[NaH].OC(=O)C1=CC=CC=C1O",1.217,1,1,1]
["S3138","Methylthiouracil","g4","L3000-14","in 10mM DMSO","ERK,Interleukins,NF-κB,TNF-alpha","NF-κB","Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.",142.18,"56-04-2",{"v":28,"d":"28.00"},196.93,"<1","N/A","http://selleckchem.com/products/methylthiouracil.html","C5H6N2OS","free base","NSC-193526, NSC-9378,MTU","CC1=CC(=O)NC(=S)N1",0.595,1,2,0]
["S3144","Darifenacin HBr","h4","L3000-14","in 10mM DMSO","AChR","Neuronal Signaling","Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.",507.46,"133099-07-7",{"v":100,"d":"100.00"},197.06,"<1","N/A","http://selleckchem.com/products/darifenacin-hydrobromide.html","C28H30N2O2.HBr","HBr","UK-88525","Br.NC(=O)C(C1CCN(CCC2=CC=C3OCCC3=C2)C1)(C4=CC=CC=C4)C5=CC=CC=C5",5.048,2,1,7]
["S3149","Estradiol valerate","a5","L3000-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol(E2V) is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.",{"v":356.5,"d":"356.50"},"979-32-8",{"v":71,"d":"71.00"},199.16,"<1","N/A","http://selleckchem.com/products/estradiol-valerate.html","C23H32O3","free base","E2V","CCCCC(=O)OC1CCC2C3CCC4=CC(=CC=C4C3CCC12C)O",5.796,2,1,5]
["S3151","Gliquidone","b5","L3000-14","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.",527.63,"33342-05-1",{"v":105,"d":"105.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/gliquidone.html","C27H33N3O6S","free base","Glurenorm,AR-DF 26","COC1=CC2=C(C=C1)C(C)(C)C(=O)N(CCC3=CC=C(C=C3)[S](=O)(=O)NC(=O)NC4CCCCC4)C2=O",4.214,6,2,7]
["S3160","Ethynodiol diacetate","c5","L3000-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ethynodiol diacetate (8080 CB,Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills.",384.51,"297-76-7",{"v":77,"d":"77.00"},200.25,{"v":77,"d":"77.00"},200.25,"http://selleckchem.com/products/ethynodiol-diacetate.html","C24H32O4","free base","8080 CB,Ethynodiol acetate","CC(=O)OC1CCC2C3CCC4(C)C(CCC4(OC(C)=O)C#C)C3CCC2=C1",4.973,4,0,4]
["S3162","Tylosin tartrate","d5","L3000-14","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture","Microbiology","Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.",1066.19,"74610-55-2",{"v":300,"d":"300.00"},281.38,{"v":200,"d":"200.00"},187.58,"http://selleckchem.com/products/tylosin-tartrate.html","C46H77NO17.C4H6O6","Tartrate","N/A","CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(OC3CC(C)(O)C(O)C(C)O3)C(C2O)N(C)C)C(CC=O)CC(C)C(=O)\\C=C\\C(=C\\C1COC4OC(C)C(O)C(OC)C4OC)C.OC(C(O)C(O)=O)C(O)=O",-2.989,14,6,16]
["S3167","Altrenogest","e5","L3000-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Altrenogest (A35957, RU2267,R2267) is a progestogen structurally related to veterinary steroid trenbolone.",310.43,"850-52-2",{"v":62,"d":"62.00"},199.72,"<1","N/A","http://selleckchem.com/products/altrenogest.html","C21H26O2","free base","A35957, RU2267,R2267","CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC=C",3.561,1,0,2]
["S3170","Ampicillin sodium","f5","L3000-14","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Ampicillin(D-(-)-α-Aminobenzylpenicillin sodium salt) is a beta-lactam antibiotic that is part of the aminopenicillin family.",371.39,"69-52-3",{"v":37,"d":"37.00"},99.63,{"v":74,"d":"74.00"},199.25,"http://selleckchem.com/products/ampicillin-sodium.html","C16H18N3NaO4S","Sodium","D-(-)-α-Aminobenzylpenicillin sodium salt","[Na+].CC1(C)SC2C(NC(=O)C(N)C3=CC=CC=C3)C(=O)N2C1C([O-])=O",-1.292,2,2,4]
["S3172","Anagrelide HCl","g5","L3000-14","in 10mM DMSO","PDE","Metabolism","Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.",292.55,"58579-51-4",{"v":14,"d":"14.00"},47.86,"<1","N/A","http://selleckchem.com/products/anagrelide-hydrochloride.html","C10H7Cl2N3O.HCl","Hydrochloride","BL-4162A,BMY 26538-01","Cl.ClC1=CC=C2NC3=NC(=O)CN3CC2=C1Cl",2.347,2,1,0]
["S3173","Antipyrine","h5","L3000-14","in 10mM DMSO","COX","Neuronal Signaling","Antipyrine (Phenazone,Phenazon) is an analgesic and antipyretic agent; selective COX-3 inhibitor.",188.23,"60-80-0",{"v":38,"d":"38.00"},201.88,{"v":38,"d":"38.00"},201.88,"http://selleckchem.com/products/antipyrine.html","C11H12N2O","free base","Phenazone,Phenazon","CN1N(C(=O)C=C1C)C2=CC=CC=C2",1.218,1,0,1]
["S3175","Atomoxetine HCl","a6","L3000-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.",291.82,"82248-59-7",{"v":58,"d":"58.00"},198.75,{"v":2,"d":"2.00"},6.85,"http://selleckchem.com/products/atomoxetine-hydrochloride.html","C17H21NO.HCl","HCl","LY 139603 HCl","Cl.CNCCC(OC1=CC=CC=C1C)C2=CC=CC=C2",3.959,1,1,6]
["S3176","Betahistine 2HCl","b6","L3000-14","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1.9 μM.",209.12,"5579-84-0",{"v":38,"d":"38.00"},181.71,{"v":38,"d":"38.00"},181.71,"http://selleckchem.com/products/betahistine-dihydrochloride.html","C8H12N2.2HCl","2HCl","PT-9","Cl.Cl.CNCCC1=NC=CC=C1",1.444,1,1,3]
["S3178","Brinzolamide","c6","L3000-14","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.",383.51,"138890-62-7",{"v":77,"d":"77.00"},200.78,"<1","N/A","http://selleckchem.com/products/brinzolamide.html","C12H21N3O5S3","free base","AL-4862","CCNC1CN(CCCOC)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",-0.772,5,2,7]
["S3180","Eletriptan HBr","d6","L3000-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Eletriptan (UK-116044) is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.",463.43,"177834-92-3",{"v":93,"d":"93.00"},200.68,"<1","N/A","http://selleckchem.com/products/eletriptan-hydrobromide.html","C22H26N2O2S.HBr","HBr","UK-116044","Br.CN1CCCC1CC2=C[NH]C3=C2C=C(CC[S](=O)(=O)C4=CC=CC=C4)C=C3",4.929,2,1,6]
["S3181","Flumequine","e6","L3000-14","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Flumequine(R-802) is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.",261.25,"42835-25-6",{"v":3,"d":"3.00"},11.48,"<1","N/A","http://selleckchem.com/products/flumequine.html","C14H12FNO3","free base","R-802","CC1CCC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2)F",{"v":2.27,"d":"2.270"},2,0,1]
["S3183","Amitriptyline HCl","f6","L3000-14","in 10mM DMSO","5-HT Receptor,Histamine Receptor,Serotonin Transporter","Neuronal Signaling","Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).",313.86,"549-18-8",{"v":63,"d":"63.00"},200.73,{"v":15,"d":"15.00"},47.79,"http://selleckchem.com/products/amitriptyline-hydrochloride.html","C20H23N.HCl","HCl","N/A","Cl.CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C13",5.154,0,0,3]
["S3185","Adrenalone HCl","g6","L3000-14","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.",217.65,"62-13-5",{"v":44,"d":"44.00"},202.16,{"v":44,"d":"44.00"},202.16,"http://selleckchem.com/products/adrenalone-hcl.html","C9H11NO3.HCl","HCl","N/A","Cl.CNCC(=O)C1=CC(=C(O)C=C1)O",0.938,1,3,3]
["S3186","Azatadine dimaleate","h6","L3000-14","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Azatadine (SCH10649,Azatadine Maleate) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.",522.55,"3978-86-7",{"v":105,"d":"105.00"},200.94,{"v":105,"d":"105.00"},200.94,"http://selleckchem.com/products/azatadine-dimaleate.html","C20H22N2.2C4H4O4","Dimaleate","SCH10649,Azatadine Maleate","CN1CCC(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C24.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",1.128,5,0,4]
["S3195","Azlocillin sodium salt","a7","L3000-14","in 10mM DMSO","Bacterial","Microbiology","Azlocillin is an acylampicillin with a broad spectrum against bacteria.",484.48,"37091-65-9",{"v":97,"d":"97.00"},200.21,{"v":97,"d":"97.00"},200.21,"http://selleckchem.com/products/azlocillin-sodium-salt.html","C20H23N5O6S.Na","Sodium Salt","N/A","[NaH].CC1(C)SC2C(NC(=O)C(NC(=O)N3CCNC3=O)C4=CC=CC=C4)C(=O)N2C1C(O)=O",0.004,5,3,5]
["S3196","Azacyclonol","b7","L3000-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.",267.37,"115-46-8",{"v":53,"d":"53.00"},198.23,{"v":2,"d":"2.00"},7.48,"http://selleckchem.com/products/azacyclonol.html","C18H21NO","free base","MER 17, MDL 4829","OC(C1CCNCC1)(C2=CC=CC=C2)C3=CC=CC=C3",2.846,0,1,3]
["S3200","Triflusal","c7","L3000-14","in 10mM DMSO","COX","Immunology & Inflammation","Triflusal (UR1501) irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.",248.16,"322-79-2",{"v":50,"d":"50.00"},201.48,"<1","N/A","http://selleckchem.com/products/triflusal.html","C10H7F3O4","free base","UR1501","CC(=O)OC1=CC(=CC=C1C(O)=O)C(F)(F)F",2.169,3,0,4]
["S3201","Trifluoperazine 2HCl","d7","L3000-14","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).",480.42,"440-17-5",{"v":88,"d":"88.00"},183.17,{"v":96,"d":"96.00"},199.83,"http://selleckchem.com/products/trifluoperazine-dihydrochloride.html","C21H24F3N3S.2HCl","2HCl","SKF5019","Cl.Cl.CN1CCN(CCCN2C3=C(SC4=CC=C(C=C24)C(F)(F)F)C=CC=C3)CC1",5.739,0,0,5]
["S3212","Moclobemide (Ro 111163)","e7","L3000-14","in 10mM DMSO","MAO","Metabolism","Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.",268.74,"71320-77-9",{"v":53,"d":"53.00"},197.22,"<1","N/A","http://selleckchem.com/products/moclobemide.html","C13H17ClN2O2","free base","N/A","ClC1=CC=C(C=C1)C(=O)NCCN2CCOCC2",1.528,2,1,4]
["S3600","Schisandrin B (Sch B)","f7","L3000-14","in 10mM DMSO","ATM/ATR,P-gp","PI3K/Akt/mTOR","Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.",400.46,"61281-37-6",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://selleckchem.com/products/schisandrin-b.html","C23H28O6","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C4OCOC4=C3OC",5.067,6,0,4]
["S3603","Betulinic acid","g7","L3000-14","in 10mM DMSO","NF-κB,Topoisomerase","DNA Damage/DNA Repair","Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.",{"v":456.7,"d":"456.70"},"472-15-1",{"v":20,"d":"20.00"},43.79,"<1","N/A","http://selleckchem.com/products/betulinic-acid.html","C30H48O3","free base","ALS-357, Lupatic acid, Betulic acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C(O)=O",6.546,1,1,2]
["S3604","Triptolide (PG490)","h7","L3000-14","in 10mM DMSO","ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-κB","NF-κB","Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.",{"v":360.4,"d":"360.40"},"38748-32-2",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/triptolide.html","C20H24O6","free base","NSC 163062","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2O",0.872,5,1,1]
["S3606","Fangchinoline","a8","L3000-14","in 10mM DMSO","Reverse Transcriptase","Microbiology","Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.",608.72,"33889-68-8",{"v":100,"d":"100.00"},164.28,"<1","N/A","http://selleckchem.com/products/r-s-fangchinoline.html","C37H40N2O6","free base","N/A","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C=C(OC6=C(O)C(=CC7=C6C(CC(=C2)C=C1)N(C)CC7)OC)C(=C5)OC)C=C3",6.992,5,1,3]
["S3608","Demethylzeylasteral (T-96)","b8","L3000-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.",480.59,"107316-88-1",{"v":96,"d":"96.00"},199.75,"<1","N/A","http://selleckchem.com/products/demethylzeylasteral-t-96.html","C29H36O6","free base","N/A","CC12CCC(C)(CC1C3(C)CCC4(C)C5=CC(=C(O)C(=C5C(=O)C=C4C3(C)CC2)C=O)O)C(O)=O",5.357,3,2,2]
["S3609","Berbamine dihydrochloride","c8","L3000-14","in 10mM DMSO","Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",681.65,"6078-17-7",{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},"http://selleckchem.com/products/berbamine-dihydrochloride.html","C37H40N2O6.2HCl","dihydrochloride","BA, BBM","Cl.Cl.COC1=CC2=C3C=C1OC4=C(OC)C(=CC5=C4C(CC6=CC(=C(O)C=C6)OC7=CC=C(CC3N(C)CC2)C=C7)N(C)CC5)OC",7.756,5,1,3]
["S3610","Cordycepin","d8","L3000-14","in 10mM DMSO","MMP","Proteases","Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.",251.24,"73-03-0",{"v":50,"d":"50.00"},199.01,{"v":25,"d":"25.00"},99.51,"http://selleckchem.com/products/cordycepin.html","C10H13N5O3","free base","3'-Deoxyadenosine","NC1=NC=NC2=C1N=C[N]2C3OC(CO)CC3O",-1.308,4,3,2]
["S3611","(+)-Fangchinoline","e8","L3000-14","in 10mM DMSO","Others","Others","Fangchinoline ((+)-Limacine, Tetrandrine B, Hanfangichin B) is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity.",608.72,"436-77-1",{"v":40,"d":"40.00"},65.71,"<1","N/A","http://selleckchem.com/products/s-s-fangchinoline.html","C37H40N2O6","free base","(+)-Limacine, Tetrandrine B, Hanfangichin B","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C=C(OC6=C7C(CC(=C2)C=C1)N(C)CCC7=CC(=C6O)OC)C(=C5)OC)C=C3",6.992,5,1,3]
["S3612","Rosmarinic acid","f8","L3000-14","in 10mM DMSO","Complement System,IκB/IKK","NF-κB","Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.",360.31,"20283-92-5",{"v":72,"d":"72.00"},199.83,{"v":24,"d":"24.00"},66.61,"http://selleckchem.com/products/rosmarinic-acid.html","C18H16O8","free base","Rosemary acid","OC(=O)C(CC1=CC=C(O)C(=C1)O)OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O",2.706,3,4,7]
["S3613","Scoparone","g8","L3000-14","in 10mM DMSO","Others","Others","Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone) is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions.",206.19,"120-08-1",{"v":41,"d":"41.00"},198.85,"<1","N/A","http://selleckchem.com/products/scoparone.html","C11H10O4","free base","6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone","COC1=CC2=C(C=CC(=O)O2)C=C1OC",1.866,4,0,2]
["S3615","Dehydrocostus Lactone","h8","L3000-14","in 10mM DMSO","IκB/IKK","NF-κB","Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.",{"v":230.3,"d":"230.30"},"477-43-0",{"v":46,"d":"46.00"},199.74,"<1","N/A","http://selleckchem.com/products/dehydrocostus-lactone.html","C15H18O2","free base","N/A","C=C1CCC2C(OC(=O)C2=C)C3C1CCC3=C",3.282,2,0,0]
["S3616","Asiaticoside","a9","L3000-14","in 10mM DMSO","ROS","Immunology & Inflammation","Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.",959.12,"16830-15-2",{"v":100,"d":"100.00"},104.26,"<1","N/A","http://selleckchem.com/products/asiaticoside.html","C48H78O19","free base","Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O",-0.101,7,12,10]
["S3621","Pazufloxacin mesylate","b9","L3000-14","in 10mM DMSO","Bacterial","Microbiology","Pazufloxacin Mesylate (T-3762, Pazucross), also known as Pazucross and T-3762, is a quinolone antibacterial agent used for the intravenous therapy of several infections.",414.41,"163680-77-1",{"v":82,"d":"82.00"},197.87,{"v":82,"d":"82.00"},197.87,"http://selleckchem.com/products/pazufloxacin-mesylate.html","C16H15FN2O4.CH4O3S","methanesulfonate","T-3762, Pazucross","CC1COC2=C(C(=CC3=C2N1C=C(C(O)=O)C3=O)F)C4(N)CC4.C[S](O)(=O)=O",-1.899,3,1,2]
["S3622","Diammonium Glycyrrhizinate","c9","L3000-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.",856.99,"79165-06-3",{"v":100,"d":"100.00"},116.69,{"v":100,"d":"100.00"},116.69,"http://selleckchem.com/products/diammonium-glycyrrhizinate.html","C42H62O16.2H3N","ammonium salt","N/A","N.N.CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",-4.247,8,5,7]
["S3625","Tyramine","d9","L3000-14","in 10mM DMSO","TAAR","GPCR & G Protein","Tyramine (4-hydroxyphenethylamine, para-tyramine, mydrial, uteramin) is a naturally occurring trace amine derived from the amino acid tyrosine and acts as a catecholamine releasing agent.",137.18,"51-67-2",{"v":27,"d":"27.00"},196.82,"<1","N/A","http://selleckchem.com/products/tyramine.html","C8H11NO","free base","4-hydroxyphenethylamine, para-tyramine, mydrial, uteramin","NCCC1=CC=C(O)C=C1",1.015,0,2,2]
["S3626","Sesamol","e9","L3000-14","in 10mM DMSO","Antioxidant","Apoptosis","Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.",138.12,"533-31-3",{"v":27,"d":"27.00"},195.48,{"v":27,"d":"27.00"},195.48,"http://selleckchem.com/products/sesamol.html","C7H6O3","free base","1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol","OC1=CC2=C(OCO2)C=C1",1.356,2,1,0]
["S3627","Tryptamine","f9","L3000-14","in 10mM DMSO","TAAR","GPCR & G Protein","Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).",160.22,"61-54-1",{"v":32,"d":"32.00"},199.73,"<1","N/A","http://selleckchem.com/products/tryptamine.html","C10H12N2","free base","N/A","NCCC1=C[NH]C2=CC=CC=C12",{"v":1.55,"d":"1.550"},0,2,2]
["S3629","Syringic acid","g9","L3000-14","in 10mM DMSO","Antioxidant","Angiogenesis","Syringic acid (NSC 2129, SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.",198.17,"530-57-4",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},{"v":1,"d":"1.00"},5.05,"http://selleckchem.com/products/syringic-acid.html","C9H10O5","free base","3,5-dimethyl ether Gallic Acid, 3,5-dimethoxy-4-hydroxy Benzoic Acid, NSC 2129, SYRA","COC1=CC(=CC(=C1O)OC)C(O)=O",1.184,3,1,3]
["S3630","Methyl Vanillate","h9","L3000-14","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.",182.17,"3943-74-6",{"v":36,"d":"36.00"},197.62,{"v":12,"d":"12.00"},65.87,"http://selleckchem.com/products/methyl-vanillate.html","C9H10O4","free base","N/A","COC(=O)C1=CC(=C(O)C=C1)OC",1.426,3,1,3]
["S3633","Pyrrolidinedithiocarbamate ammonium","a10","L3000-14","in 10mM DMSO","NF-κB","NF-κB","Pyrrolidinedithiocarbamate ammonium  (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.",164.29,"5108-96-3",{"v":32,"d":"32.00"},194.78,{"v":32,"d":"32.00"},194.78,"http://selleckchem.com/products/pyrrolidinedithiocarbamate-ammoniumammonium.html","C5H9NS2.H3N","ammonium salt","APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt","N.SC(=S)N1CCCC1",2.172,0,0,1]
["S3639","Tacrine hydrochloride hydrate","b10","L3000-14","in 10mM DMSO","AChR,HNMT","Neuronal Signaling","Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.","198.26(free bases)","206658-92-6",{"v":50,"d":"50.00"},252.19,{"v":50,"d":"50.00"},252.19,"http://selleckchem.com/products/tacrine-hydrochloride-hydrate.html","C13H14N2.xHCl.xH2O","hydrochloride hydrate","Tacrine, Tetrahydroaminacrine, Tetrahydroaminoacridine","NC1=C2C=CC=CC2=NC3=C1CCCC3",4.258,1,1,0]
["S3641","Osalmid","c10","L3000-14","in 10mM DMSO","DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.",229.23,"526-18-1",{"v":45,"d":"45.00"},196.31,"<1","N/A","http://selleckchem.com/products/osalmid.html","C13H11NO3","free base","N/A","OC1=CC=C(NC(=O)C2=C(O)C=CC=C2)C=C1",{"v":2.13,"d":"2.130"},1,3,2]
["S3643","Amitraz","d10","L3000-14","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.",293.41,"33089-61-1",{"v":58,"d":"58.00"},197.68,"<1","N/A","http://selleckchem.com/products/amitraz.html","C19H23N3","free base","NSC 324552","CN(C=NC1=CC=C(C)C=C1C)C=NC2=CC=C(C)C=C2C",4.825,2,0,4]
["S3647","Mafenide Acetate","e10","L3000-14","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.",246.28,"13009-99-9",{"v":49,"d":"49.00"},198.96,{"v":49,"d":"49.00"},198.96,"http://selleckchem.com/products/mafenide-acetate.html","C7H10N2O2S.C2H4O2","acetate","N/A","CC(O)=O.NCC1=CC=C(C=C1)[S](N)(=O)=O",-3.043,3,2,2]
["S3648","Amlexanox (AA-673)","f10","L3000-14","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK,TBK1","Immunology & Inflammation","Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.",298.29,"68302-57-8",{"v":59,"d":"59.00"},197.79,"<1","N/A","http://selleckchem.com/products/amlexanox.html","C16H14N2O4","free base","CHX-3673, Amoxanox","CC(C)C1=CC2=C(OC3=NC(=C(C=C3C2=O)C(O)=O)N)C=C1",2.969,4,1,2]
["S3651","4-Amino-5-imidazolecarboxamide","g10","L3000-14","in 10mM DMSO","Others","Others","4-Amino-5-imidazolecarboxamide is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides.",126.12,"360-97-4",{"v":25,"d":"25.00"},198.22,{"v":25,"d":"25.00"},198.22,"http://selleckchem.com/products/4-amino-5-imidazolecarboxamide.html","C4H6N4O","free base","N/A","NC(=O)C1=C(N)[NH]C=N1",-1.475,2,3,1]
["S3653","Spermidine trihydrochloride","h10","L3000-14","in 10mM DMSO","Autophagy,NMDAR","Neuronal Signaling","Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).",254.63,"334-50-9",{"v":30,"d":"30.00"},117.82,{"v":50,"d":"50.00"},196.36,"http://selleckchem.com/products/spermidine-trihydrochloride.html","C7H19N3.3HCl","trihydrochloride","4-Azaoctamethylenediamine trihydrochloride","Cl.Cl.Cl.NCCCCNCCCN",-0.024,0,3,7]
["S3654","Tauroursodeoxycholic Acid (TUDCA)","a11","L3000-14","in 10mM DMSO","Mitochondrial Metabolism","Neuronal Signaling","Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).",{"v":499.7,"d":"499.70"},"14605-22-2",{"v":99,"d":"99.00"},198.12,{"v":30,"d":"30.00"},60.04,"http://selleckchem.com/products/tauroursodeoxycholic-acid.html","C26H45NO6S","free base","N/A","CC(CCC(=O)NCC[S](O)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",2.997,1,3,7]
["S3655","Cefepime Dihydrochloride Monohydrate","b11","L3000-14","in 10mM DMSO","Bacterial","Microbiology","Cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intra-abdominal infections.",{"v":571.5,"d":"571.50"},"123171-59-5",{"v":100,"d":"100.00"},174.98,{"v":1,"d":"1.00"},1.75,"http://selleckchem.com/products/cefepime-dihydrochloride-monohydrate.html","C19H25N6O5S2.HCl.Cl.H2O","dihydrochloride hydrate","N/A","O.Cl.Cl.CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3(C)CCCC3)C4=CSC(=N4)N",-2.421,5,2,7]
["S3656","Piribedil","c11","L3000-14","in 10mM DMSO","Adrenergic Receptor,Dopamine Receptor","Neuronal Signaling","Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.",298.34,"3605-01-4",{"v":59,"d":"59.00"},197.76,"<1","N/A","http://selleckchem.com/products/piribedil.html","C16H18N4O2","free base","Trivastal, Trivastan","C1OC2=CC=C(CN3CCN(CC3)C4=NC=CC=N4)C=C2O1",2.043,4,0,3]
["S3657","Promestriene","d11","L3000-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application.",328.49,"39219-28-8",{"v":65,"d":"65.00"},197.88,{"v":3,"d":"3.00"},9.13,"http://selleckchem.com/products/promestriene.html","C22H32O2","free base","3-propyl ethyl, 17B-methyl estradiol","CCCOC1=CC2=C(C=C1)C3CCC4(C)C(CCC4C3CC2)OC",5.344,2,0,4]
["S3658","O6-Benzylguanine","e11","L3000-14","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.",241.25,"19916-73-5",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/o6-benzylguanine.html","C12H11N5O","free base","O6-BG","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3=CC=CC=C3",1.646,4,2,3]
["S3659","Fludrocortisone acetate","f11","L3000-14","in 10mM DMSO","Others","Others","Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.",422.49,"514-36-3",{"v":84,"d":"84.00"},198.82,"<1","N/A","http://selleckchem.com/products/fludrocortisone-acetate.html","C23H31FO6","free base","9α-fluorocortisol acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC12C",1.791,4,1,4]
["S3661","2-Methoxy-1,4-naphthoquinone","g11","L3000-14","in 10mM DMSO","PKC","Cytoskeletal Signaling","2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.",188.18,"2348-82-5",{"v":37,"d":"37.00"},196.62,"<1","N/A","http://selleckchem.com/products/2-methoxy-1-4-naphthoquinone.html","C11H8O3","free base","N/A","COC1=CC(=O)C2=C(C=CC=C2)C1=O",1.445,3,0,1]
["S3665","Trolox","h11","L3000-14","in 10mM DMSO","Vitamin","Metabolism","Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.",250.29,"53188-07-1",{"v":50,"d":"50.00"},199.77,"<1","N/A","http://selleckchem.com/products/trolox.html","C14H18O4","free base","N/A","CC1=C(C)C2=C(CCC(C)(O2)C(O)=O)C(=C1O)C",3.489,2,1,1]
["S3666","Ilaprazole","a2","L3000-15","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.",366.44,"172152-36-2",{"v":73,"d":"73.00"},199.21,"<1","N/A","http://selleckchem.com/products/ilaprazole.html","C19H18N4O2S","free base","IY-81149","COC1=CC=NC(=C1C)C[S](=O)C2=NC3=C([NH]2)C=C(C=C3)[N]4C=CC=C4",3.311,4,1,5]
["S3668","Thymopentin","b2","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.",679.77,"69558-55-0",{"v":100,"d":"100.00"},147.11,{"v":100,"d":"100.00"},147.11,"http://selleckchem.com/products/thymopentin.html","C30H49N9O9","free base","TP5","CC(C)C(NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC1=CC=C(O)C=C1)C(O)=O",-6.675,6,9,23]
["S3669","Carmustine","c2","L3000-15","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.",214.05,"154-93-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carmustine.html","C5H9Cl2N3O2","free base","bis-chloroethylnitrosourea, BCNU, BiCNU","ClCCNC(=O)N(CCCl)N=O",1.201,2,1,5]
["S3671","Quinestrol","d2","L3000-15","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.",364.52,"152-43-2",{"v":72,"d":"72.00"},197.52,"<1","N/A","http://selleckchem.com/products/quinestrol.html","C25H32O2","free base","Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566","CC12CCC3C(CCC4=C3C=CC(=C4)OC5CCCC5)C1CCC2(O)C#C",6.514,1,0,2]
["S3672","Cefonicid sodium","e2","L3000-15","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefonicid sodium (Monocid) is a cephalosporin antibiotic. It interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism.",586.53,"61270-78-8",{"v":100,"d":"100.00"},170.49,{"v":100,"d":"100.00"},170.49,"http://selleckchem.com/products/cefonicid-sodium.html","C18H16N6O8S3.2Na","disodium salt","Monocid sodium","[Na+].[Na+].OC(C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)CSC3=NN=N[N]3C[S]([O-])(=O)=O)C4=CC=CC=C4",-4.327,5,2,9]
["S3675","Umbelliferone","f2","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.",162.14,"93-35-6",{"v":32,"d":"32.00"},197.36,"<1","N/A","http://selleckchem.com/products/umbelliferone.html","C9H6O3","free base","7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone","OC1=CC2=C(C=C1)C=CC(=O)O2",1.657,2,1,0]
["S3676","Carbendazim","g2","L3000-15","in 10mM DMSO","Fungal","Microbiology","Carbendazim (Mercarzole, Carbendazole) is a broad-spectrum systemic antimycotic and can be used to control a broad range of diseases on field crops, fruits, and vegetables, including sclerotinia rot of canola, wheat head blight, peanut leaf spot, and SB on rice. Its mode of action is to inhibit the formation of mitotic microtubules in of fungi.",191.19,"10605-21-7",{"v":17,"d":"17.00"},88.92,"<1","N/A","http://selleckchem.com/products/carbendazim.html","C9H9N3O2","free base","Mercarzole, Carbendazole","COC(=O)NC1=NC2=C([NH]1)C=CC=C2",{"v":1.65,"d":"1.650"},3,2,2]
["S3677","Cinnamic acid","h2","L3000-15","in 10mM DMSO","Others","Others","Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.",148.16,"140-10-3",{"v":29,"d":"29.00"},195.73,"<1","N/A","http://selleckchem.com/products/cinnamic-acid.html","C9H8O2","free base","trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid","OC(=O)/C=C/C1=CC=CC=C1",1.927,1,0,2]
["S3679","Flavanone","a3","L3000-15","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties.",224.25,"487-26-3",{"v":44,"d":"44.00"},196.21,"<1","N/A","http://selleckchem.com/products/flavanone.html","C15H12O2","free base","2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one","O=C1CC(OC2=C1C=CC=C2)C3=CC=CC=C3",3.099,2,0,1]
["S3681","Vitamin E Acetate","b3","L3000-15","in 10mM DMSO","Vitamin","Metabolism","Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant., Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. ,",472.74,"58-95-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e-acetate.html","C31H52O3","free base","Tocopherol acetate","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)OC(C)=O",{"v":10.45,"d":"10.450"},3,0,14]
["S3683","Methylmalonate","c3","L3000-15","in 10mM DMSO","Others","Others","Methylmalonate (Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA).",118.09,"516-05-2",{"v":23,"d":"23.00"},194.77,{"v":23,"d":"23.00"},194.77,"http://selleckchem.com/products/methylmalonate.html","C4H6O4","free base","Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA","CC(C(O)=O)C(O)=O",0.068,2,0,2]
["S3684","Methacholine chloride","d3","L3000-15","in 10mM DMSO","AChR","Neuronal Signaling","Methacholine (Mecholyl, Acetyl-β-methylcholine) is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.",195.69,"62-51-1",{"v":39,"d":"39.00"},199.29,{"v":39,"d":"39.00"},199.29,"http://selleckchem.com/products/methacholine-chloride.html","C8H18NO2.Cl","chloride","Mecholyl chloride, Acetyl-β-methylcholine chloride","[Cl-].CC(C[N+](C)(C)C)OC(C)=O",-3.492,2,0,4]
["S3687","Urea","e3","L3000-15","in 10mM DMSO","Others","Metabolism","Urea (Carbonyldiamide, Ureophil) is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.",60.06,"57-13-6",{"v":12,"d":"12.00"},{"v":199.8,"d":"199.80"},{"v":12,"d":"12.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/urea.html","CH4N2O","free base","Carbonyldiamide, Ureophil","NC(N)=O",-1.043,1,2,0]
["S3690","Pargyline hydrochloride","f3","L3000-15","in 10mM DMSO","MAO","Metabolism","Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.",195.69,"306-07-0",{"v":39,"d":"39.00"},199.29,{"v":39,"d":"39.00"},199.29,"http://selleckchem.com/products/pargyline-hydrochloride.html","C11H13N.HCl","hydrochloride","Pargylamine hydrochloride","Cl.CN(CC#C)CC1=CC=CC=C1",3.477,0,0,3]
["S3692","N-Ethylmaleimide (NEM)","g3","L3000-15","in 10mM DMSO","Cysteine Protease,DUB","Proteases","N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.",125.13,"128-53-0",{"v":25,"d":"25.00"},199.79,{"v":25,"d":"25.00"},199.79,"http://selleckchem.com/products/n-ethylmaleimide-nem.html","C6H7NO2","free base","N/A","CCN1C(=O)C=CC1=O",{"v":0.16,"d":"0.160"},2,0,1]
["S3694","Glucosamine hydrochloride","h3","L3000-15","in 10mM DMSO","Others","Immunology & Inflammation","Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.",215.63,"66-84-2",{"v":4,"d":"4.00"},18.55,{"v":43,"d":"43.00"},199.42,"http://selleckchem.com/products/glucosamine-hydrochloride.html","C6H13NO5.HCl","hydrochloride","2-Amino-2-deoxy-glucose HCl, Chitosamine HCl","Cl.NC1C(O)OC(CO)C(O)C1O",-2.422,1,4,1]
["S3695","Cystamine dihydrochloride","a4","L3000-15","in 10mM DMSO","Anti-infection","Microbiology","Cystamine dihydrochloride (Decarboxycystine, 2-Aminoethyl disulfide, 2,2'-Dithiobisethanamine) acts as an anti-infective agent, which is used in the treatment of urinary tract infections and also as a radiation-protective agent that interferes with sulfhydryl enzymes.",{"v":225.2,"d":"225.20"},"56-17-7",{"v":14,"d":"14.00"},62.17,{"v":45,"d":"45.00"},199.82,"http://selleckchem.com/products/cystamine-dihydrochloride.html","C4H12N2S2.2HCl","dihydrochloride","Decarboxycystine dihydrochloride, 2-Aminoethyl disulfide dihydrochloride, 2,2'-Dithiobisethanamine dihydrochloride","Cl.Cl.NCCSSCCN",0.491,0,2,5]
["S3696","PTP Inhibitor I","b4","L3000-15","in 10mM DMSO","phosphatase","Metabolism","PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.",215.04,"2491-38-5",{"v":43,"d":"43.00"},199.96,"<1","N/A","http://selleckchem.com/products/ptp-inhibitor-i.html","C8H7BrO2","free base","α-Bromo-4-hydroxyacetophenone, 2-Bromo-4'-hydroxyacetophenone, 4-Hydroxyphenacyl bromide, SHP-1 Inhibitor II","OC1=CC=C(C=C1)C(=O)CBr",2.005,1,1,2]
["S3697","Mafenide hydrochloride","c4","L3000-15","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.",222.69,"138-37-4",{"v":44,"d":"44.00"},197.58,{"v":44,"d":"44.00"},197.58,"http://selleckchem.com/products/mafenide-hydrochloride.html","C7H10N2O2S.HCl","hydrochloride","4-Aminomethylbenzenesulfonamide hydrochloride","Cl.NCC1=CC=C(C=C1)[S](N)(=O)=O",0.023,2,2,2]
["S3698","Nortriptyline hydrochloride","d4","L3000-15","in 10mM DMSO","Autophagy","Autophagy","Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.",299.84,"894-71-3",{"v":59,"d":"59.00"},196.77,{"v":59,"d":"59.00"},196.77,"http://selleckchem.com/products/nortriptyline-hydrochloride.html","C19H21N.HCl","hydrochloride","Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride","Cl.CNCCC=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.618,0,1,3]
["S3699","2,3-Butanedione-2-monoxime","e4","L3000-15","in 10mM DMSO","MLCK","Cytoskeletal Signaling","2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.",{"v":101.1,"d":"101.10"},"57-71-6",{"v":20,"d":"20.00"},197.82,{"v":20,"d":"20.00"},197.82,"http://selleckchem.com/products/2-3-butanedione-2-monoxime.html","C4H7NO2","free base","Diacetyl monoxime, Diacetylmonoxime","CC(=O)\\C(C)=N\\O",-0.161,2,0,1]
["S3701","Benactyzine hydrochloride","f4","L3000-15","in 10mM DMSO","AChR","Neuronal Signaling","Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety.",363.88,"57-37-4",{"v":72,"d":"72.00"},197.87,{"v":72,"d":"72.00"},197.87,"http://selleckchem.com/products/benactyzine-hydrochloride.html","C20H25NO3.HCl","hydrochloride","N/A","Cl.CCN(CC)CCOC(=O)C(O)(C1=CC=CC=C1)C2=CC=CC=C2",3.832,2,0,9]
["S3702","Dihydrothymine","g4","L3000-15","in 10mM DMSO","Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Dihydrothymine is an intermediate breakdown product of thymine.",128.13,"696-04-8",{"v":25,"d":"25.00"},195.11,{"v":11,"d":"11.00"},85.85,"http://selleckchem.com/products/dihydrothymine.html","C5H8N2O2","free base","N/A","CC1CNC(=O)NC1=O",{"v":-0.45,"d":"-0.450"},2,2,0]
["S3707","Ethopabate","h4","L3000-15","in 10mM DMSO","Parasite","Microbiology","Ethopabate (ETP, Ethyl pabate) is a coccidiostat that is frequently used to prevent and treat coccidiosis in chickens.",237.25,"59-06-3",{"v":47,"d":"47.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/ethopabate.html","C12H15NO4","free base","Ethyl pabate","CCOC1=CC(=CC=C1C(=O)OC)NC(C)=O",1.138,4,1,5]
["S3711","Carbasalate Calcium","a5","L3000-15","in 10mM DMSO","Anti-infection","Microbiology","Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor.",458.43,"5749-67-7",{"v":11,"d":"11.00"},23.99,{"v":91,"d":"91.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/carbasalate-calcium.html","C18H14O8.CH4N2O.Ca","calcium salt","Iromin, Alcacyl, Omegin, Rheomin, Solupsan","CC(=O)OC1=C(C=CC=C1)C(=O)O[Ca]OC(=O)C2=C(OC(C)=O)C=CC=C2.NC(N)=O",1.594,9,2,10]
["S3714","Lifitegrast","b5","L3000-15","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.",615.48,"1025967-78-5",{"v":100,"d":"100.00"},162.47,"<1","N/A","http://selleckchem.com/products/lifitegrast.html","C29H24Cl2N2O7S","free base","SAR1118,SHP-606","C[S](=O)(=O)C1=CC=CC(=C1)CC(NC(=O)C2=C(Cl)C=C3CN(CCC3=C2Cl)C(=O)C4=CC=C5C=COC5=C4)C(O)=O",{"v":4.79,"d":"4.790"},6,1,7]
["S3720","Elafibranor","c5","L3000-15","in 10mM DMSO","PPAR","Metabolism","Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation.",384.49,"923978-27-2",{"v":76,"d":"76.00"},197.66,"<1","N/A","http://selleckchem.com/products/elafibranor.html","C22H24O4S","free base","GFT505","CSC1=CC=C(C=C1)C(=O)\\C=C\\C2=CC(=C(OC(C)(C)C(O)=O)C(=C2)C)C",5.477,3,0,7]
["S3724","Velpatasvir","d5","L3000-15","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Velpatasvir (GS-5816,VEL) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial \"membranous web\" that facilitates RNA replication.",{"v":883,"d":"883.00"},"1377049-84-7",{"v":100,"d":"100.00"},113.25,{"v":100,"d":"100.00"},113.25,"http://selleckchem.com/products/velpatasvir.html","C49H54N8O8","free base","GS-5816,VEL","COCC1CC(N(C1)C(=O)C(NC(=O)OC)C2=CC=CC=C2)C3=NC=C([NH]3)C4=CC=C5C(=C4)COC6=C5C=C7C=CC8=C(N=C([NH]8)C9CCC(C)N9C(=O)C(NC(=O)OC)C(C)C)C7=C6",5.789,10,4,13]
["S3725","ELR-510444","e5","L3000-15","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells.",368.47,"1233948-35-0",{"v":73,"d":"73.00"},198.12,"<1","N/A","http://selleckchem.com/products/elr-510444.html","C19H16N2O2S2","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=CC=C2C)C3=CC=C(S3)C#N",4.932,2,1,4]
["S3731","Tipiracil hydrochloride","f5","L3000-15","in 10mM DMSO","Phosphorylase,Thymidylate Synthase","Metabolism","Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.",279.12,"183204-72-0",{"v":8,"d":"8.00"},28.66,{"v":55,"d":"55.00"},197.05,"http://selleckchem.com/products/tipiracil-hydrochloride.html","C9H11ClN4O2.HCl","hydrochloride","MA-1 hydrochloride","Cl.ClC1=C(CN2CCCC2=N)NC(=O)NC1=O",-0.388,2,2,2]
["S3732","Avibactam sodium","g5","L3000-15","in 10mM DMSO","β-lactamase","Microbiology","Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.",287.23,"1192491-61-4",{"v":57,"d":"57.00"},198.45,{"v":57,"d":"57.00"},198.45,"http://selleckchem.com/products/avibactam-sodium.html","C7H10N3O6.Na","sodium salt","AVE-1330A, NXL104","[Na+].NC(=O)C1CCC2CN1C(=O)N2O[S]([O-])(=O)=O",-3.785,3,1,3]
["S3739","Calcipotriene","h5","L3000-15","in 10mM DMSO","Vitamin","Metabolism","Calcipotriene (Calcipotriol, MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth.  Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.",{"v":412.6,"d":"412.60"},"112965-21-6",{"v":82,"d":"82.00"},198.74,"<1","N/A","http://selleckchem.com/products/calcipotriene.html","C27H40O3","free base","Calcipotriol, MC903","CC(\\C=C\\C(O)C1CC1)C2CCC3/C(CCCC23C)=C/C=C\\4CC(O)CC(O)C4=C",4.679,0,3,5]
["S3742","Cholic acid","a6","L3000-15","in 10mM DMSO","Others","Metabolism","Cholic acid is a naturally occurring bile acid that is insoluble in water and is used to treat patients with genetic deficiencies in the synthesis of bile acids.",408.57,"81-25-4",{"v":81,"d":"81.00"},198.25,"<1","N/A","http://selleckchem.com/products/cholic-acid.html","C24H40O5","free base","N/A","CC(CCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",2.912,1,3,4]
["S3745","Balsalazide disodium","b6","L3000-15","in 10mM DMSO","Immunology & Inflammation related,Interleukins,STAT","Immunology & Inflammation","Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.",437.31,"150399-21-6",{"v":87,"d":"87.00"},198.94,{"v":87,"d":"87.00"},198.94,"http://selleckchem.com/products/balsalazide-disodium.html","C17H13N3O6.2H2O.2Na","disodium salt dihydrate","N/A","O.O.[Na+].[Na+].OC1=CC=C(C=C1C([O-])=O)N=NC2=CC=C(C=C2)C(=O)NCCC([O-])=O",-0.838,3,2,7]
["S3751","Quinidine hemisulfate hydrate","c6","L3000-15","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.",391.47,"6591-63-5",{"v":100,"d":"100.00"},154.12,{"v":9,"d":"9.00"},13.87,"http://selleckchem.com/products/quinidine-sulfate.html","C20H24N2O2.1/2H2SO4.H2O","hemisulfate hydrate","Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium","O.O.COC1=CC2=C(C=C1)N=CC=C2C(O)C3CC4CCN3CC4C=C.COC5=CC6=C(C=C5)N=CC=C6C(O)C7CC8CCN7CC8C=C.O[S](O)(=O)=O",4.446,4,2,8]
["S3757","2'-Deoxyinosine","d6","L3000-15","in 10mM DMSO","Others","Others","2’-Deoxyinosine (Guanine deoxyriboside, Deoxyinosine) is the nucleoside form of hypoxanthine. It is a product of DNA damage that is formed from 2’-deoxyadenosine by adenosine deaminase or reactive nitrogen species. 2’-deoxyinosine enhances apoptosis induced by 5-fluorouracil in HT-29 and SW620 cancer cells.",252.23,"890-38-0",{"v":24,"d":"24.00"},95.15,"N/A","N/A","http://selleckchem.com/products/2-deoxyinosine.html","C10H12N4O4","free base","Guanine deoxyriboside, Deoxyinosine","OCC1OC(CC1O)[N]2C=NC3=C2N=CNC3=O",-1.482,4,3,2]
["S3758","Sinomenine hydrochloride","e6","L3000-15","in 10mM DMSO","Autophagy,Immunology & Inflammation related","Immunology & Inflammation","Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.",365.85,"6080-33-7",{"v":73,"d":"73.00"},199.54,"N/A","N/A","http://selleckchem.com/products/sinomenine-hydrochloride.html","C19H23NO4.HCl","hydrochloride","Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride","Cl.COC1=C(O)C2=C(CC3C4C=C(OC)C(=O)CC24CCN3C)C=C1",2.056,3,1,2]
["S3759","Norcantharidin","f6","L3000-15","in 10mM DMSO","c-Met,EGFR","Protein Tyrosine Kinase","Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.",168.15,"29745-04-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/norcantharidin.html","C8H8O4","free base","Endothall anhydride","O=C1OC(=O)C2C3CCC(O3)C12",-0.117,4,0,0]
["S3765","Picroside II","g6","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.",512.46,"39012-20-9",{"v":100,"d":"100.00"},195.14,"N/A","N/A","http://selleckchem.com/products/picroside-ii.html","C23H28O13","free base","6-Vanilloylcatalpol, Vanilloyl catalpol","COC1=CC(=CC=C1O)C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C5(CO)OC25",-1.796,7,6,8]
["S3766","Tanshinone IIA sulfonate sodium","h6","L3000-15","in 10mM DMSO","Calcium Channel,P2 Receptor,P450 (e.g. CYP17)","Metabolism","Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC).",396.39,"69659-80-9",{"v":79,"d":"79.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","http://selleckchem.com/products/tanshinone-iia-sulfonate-sodium.html","C19H17O6S.Na","sodium salt","N/A","[Na+].CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)[S]([O-])(=O)=O",1.873,3,0,1]
["S3769","Palmatine","a7","L3000-15","in 10mM DMSO","AChR","Neuronal Signaling","Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.",{"v":352.4,"d":"352.40"},"3486-67-7",{"v":70,"d":"70.00"},198.64,"N/A","N/A","http://selleckchem.com/products/palmatine.html","C21H22NO4","free base","Berbericinine, Burasaine","COC1=CC2=C(C=C1OC)C3=CC4=C(C=[N+]3CC2)C(=C(OC)C=C4)OC",4.161,4,0,4]
["S3771","Stachydrine","b7","L3000-15","in 10mM DMSO","NF-κB","NF-κB","Stachydrine (Proline betaine, L-stachydrine, Methyl hygrate betaine) is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.",143.18,"471-87-4",{"v":28,"d":"28.00"},195.56,"N/A","N/A","http://selleckchem.com/products/stachydrine.html","C7H13NO2","inner salt","Proline betaine, L-stachydrine, Methyl hygrate betaine","C[N+]1(C)CCCC1C([O-])=O",-2.431,0,0,1]
["S3774","Dehydroandrographolide Succinate Potasium Salt","c7","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.",570.67,"76958-99-1",{"v":10,"d":"10.00"},17.52,"N/A","N/A","http://selleckchem.com/products/dehydroandrographolide-succinate-potasium-salt.html","C28H35O10.K","potassium salt","N/A","[K+].CC1(COC(=O)CCC([O-])=O)C(CCC2(C)C1CCC(=C)C2\\C=C\\C3=CCOC3=O)OC(=O)CCC(O)=O",1.553,7,0,13]
["S3776","Sophoricoside","d7","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.",432.38,"152-95-4",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","http://selleckchem.com/products/sophoricoside.html","C21H20O10","Isoflavone glycoside","N/A","OCC1OC(OC2=CC=C(C=C2)C3=COC4=C(C(=CC(=C4)O)O)C3=O)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S3778","Patchouli alcohol","e7","L3000-15","in 10mM DMSO","Fungal","Microbiology","Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.",222.37,"5986-55-0",{"v":44,"d":"44.00"},197.87,"N/A","N/A","http://selleckchem.com/products/patchouli-alcohol.html","C15H26O","free base","(-)-Patchouli Alcohol, Patchoulol, Patchouli camphor","CC1CCC2(O)C(C)(C)C3CCC2(C)C1C3",3.427,0,0,0]
["S3779","cis-Anethole","f7","L3000-15","in 10mM DMSO","Others","Others","Anethole ((Z)-Anethole, Cis-p-Propenylanisole, Cis-p-Anethole) has two isomers, the cis(Z) isomer being 15-38 times more toxic to animal than the trans(E) isomer. cis-Anethole is found in anise and Only a low level is permitted in flavours.",{"v":148.2,"d":"148.20"},"104-46-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/cis-anethole.html","C10H12O","free base","(Z)-Anethole, Cis-p-Propenylanisole, Cis-p-Anethole","COC1=CC=C(\\C=C\\C)C=C1",2.767,1,0,2]
["S3780","Secoisolariciresinol diglucoside","g7","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.",{"v":686.7,"d":"686.70"},"148244-82-0",{"v":100,"d":"100.00"},145.62,{"v":100,"d":"100.00"},145.62,"http://selleckchem.com/products/secoisolariciresinol-diglucoside.html","C32H46O16","free base","N/A","COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC",-0.651,6,10,15]
["S3784","Obacunone (AI3-37934)","h7","L3000-15","in 10mM DMSO","Aromatase,Nrf2","Endocrinology & Hormones","Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.",454.51,"751-03-1",{"v":90,"d":"90.00"},198.02,"N/A","N/A","http://selleckchem.com/products/obacunone.html","C26H30O7","free base","CCRIS 8657","CC1(C)OC(=O)C=CC2(C)C3CCC4(C)C(OC(=O)C5OC45C3(C)C(=O)CC12)C6=COC=C6",2.715,7,0,1]
["S3785","Notoginsenoside R1","a8","L3000-15","in 10mM DMSO","Akt,ERK,PAI-1,PI3K","Metabolism","Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.",933.13,"80418-24-2",{"v":100,"d":"100.00"},107.17,"N/A","N/A","http://selleckchem.com/products/notoginsenoside-r1.html","C47H80O18","free base","Sanchinoside R1, NG-R1, NGR1","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(CO)C(O)C(O)C6OC7OCC(O)C(O)C7O",{"v":-0.11,"d":"-0.110"},6,12,12]
["S3786","Glabridin","b8","L3000-15","in 10mM DMSO","GABA Receptor,PPAR","Metabolism","Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.",324.37,"59870-68-7",{"v":64,"d":"64.00"},197.31,"N/A","N/A","http://selleckchem.com/products/glabridin.html","C20H20O4","free base","Q-100692, KB-289522, LS-176045","CC1(C)OC2=C(C=C1)C3=C(CC(CO3)C4=CC=C(O)C=C4O)C=C2",3.999,2,2,1]
["S3787","Picroside I","c8","L3000-15","in 10mM DMSO","Anti-infection","Microbiology","Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.",492.47,"27409-30-9",{"v":98,"d":"98.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/picroside-i.html","C24H28O11","free base","6'-Cinnamoylcatalpol","OCC12OC1C(O)C3C=COC(OC4OC(COC(=O)\\C=C\\C5=CC=CC=C5)C(O)C(O)C4O)C23",{"v":-1.07,"d":"-1.070"},6,5,8]
["S3788","Carvacrol","d8","L3000-15","in 10mM DMSO","AChR","Neuronal Signaling","Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.",150.22,"499-75-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carvacrol.html","C10H14O","free base","cymophenol","CC(C)C1=CC=C(C)C(=C1)O",3.268,0,1,1]
["S3790","Methyl gallate","e8","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.",184.15,"99-24-1",{"v":36,"d":"36.00"},359.57,"N/A","N/A","http://selleckchem.com/products/methyl-gallate.html","C8H8O5","free base","Methylgallate, Gallic acid methyl ester, Gallicin","COC(=O)C1=CC(=C(O)C(=C1)O)O",0.959,2,3,2]
["S3792","Guggulsterone E&Z","f8","L3000-15","in 10mM DMSO","FXR","Metabolism","Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.",312.45,"95975-55-6",{"v":62,"d":"62.00"},198.43,"N/A","N/A","http://selleckchem.com/products/guggulsterone.html","C21H28O2","free base","N/A","CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",4.031,2,0,0]
["S3794","Palmitic acid","g8","L3000-15","in 10mM DMSO","Others","Others","Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.",256.42,"57-10-3",{"v":51,"d":"51.00"},198.89,"N/A","N/A","http://selleckchem.com/products/palmitic-acid.html","C16H32O2","free base","hexadecanoic acid, Cetylic acid","CCCCCCCCCCCCCCCC(O)=O",6.393,1,0,14]
["S3800","Lycorine hydrochloride","h8","L3000-15","in 10mM DMSO","ADC Cytotoxin,HCV Protease","Proteases","Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.",323.77,"2188-68-3",{"v":64,"d":"64.00"},197.67,"N/A","N/A","http://selleckchem.com/products/lycorine-hydrochloride.html","C16H17NO4.HCl","hydrochloride","Galanthidine hydrochloride, Amarylline hydrochloride, Narcissine hydrochloride, Licorine hydrochloride","Cl.OC1C=C2CCN3CC4=C(C=C5OCOC5=C4)C(C1O)C23",1.095,2,2,0]
["S3802","Trigonelline Hydrochloride","a9","L3000-15","in 10mM DMSO","Bacterial","Microbiology","Trigonelline (Nicotinic acid N-methylbetaine, Coffearine, Gynesine), a major alkaloid component of fenugreek, has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and also has been shown to reduce diabetic auditory neuropathy and platelet aggregation.",{"v":173.6,"d":"173.60"},"6138-41-6",{"v":18,"d":"18.00"},103.69,"N/A","N/A","http://selleckchem.com/products/trigonelline-hydrochloride.html","C7H8NO2.Cl","chloride","Nicotinic acid N-methylbetaine Hydrochloride, Coffearine Hydrochloride, Gynesine Hydrochloride","[Cl-].C[N+]1=CC(=CC=C1)C(O)=O",{"v":-1.61,"d":"-1.610"},1,0,1]
["S3804","Alpha-Mangostin","b9","L3000-15","in 10mM DMSO","Dehydrogenase,STING","Metabolism","Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities.    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.",410.46,"6147-11-1",{"v":82,"d":"82.00"},199.78,"N/A","N/A","http://selleckchem.com/products/alpha-mangostin.html","C24H26O6","free base","N/A","COC1=C(O)C=C2OC3=C(C(=C(CC=C(C)C)C(=C3)O)O)C(=O)C2=C1CC=C(C)C",5.935,3,3,5]
["S3805","Stevioside","c9","L3000-15","in 10mM DMSO","Others","Others","Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni.",804.87,"57817-89-7",{"v":100,"d":"100.00"},124.24,"N/A","N/A","http://selleckchem.com/products/stevioside.html","C38H60O18","free base","N/A","CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O",-1.729,7,11,10]
["S3807","Dehydroandrographolide","d9","L3000-15","in 10mM DMSO","Chloride Channel","Transmembrane Transporters","Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.",332.43,"134418-28-3",{"v":66,"d":"66.00"},198.54,"N/A","N/A","http://selleckchem.com/products/dehydroandrographolide.html","C20H28O4","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C3/C=COC3=O)C(=C)CCC12",2.502,2,2,3]
["S3808","Mangiferin","e9","L3000-15","in 10mM DMSO","NF-κB,Nrf2","Immunology & Inflammation","Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.",422.34,"4773-96-0",{"v":84,"d":"84.00"},198.89,"N/A","N/A","http://selleckchem.com/products/mangiferin.html","C19H18O11","free base","Alpizarin, Chinomin, Hedysarid","OCC1OC(C(O)C(O)C1O)C2=C(O)C=C3OC4=C(C=C(O)C(=C4)O)C(=O)C3=C2O",-0.396,3,8,2]
["S3809","Imperatorin","f9","L3000-15","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.",270.28,"482-44-0",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/imperatorin.html","C16H14O4","free base","Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen, 8-Isopentenyloxypsoralene","CC(C)=CCOC1=C2OC(=O)C=CC2=CC3=C1OC=C3",3.652,4,0,3]
["S3810","Scutellarin","g9","L3000-15","in 10mM DMSO","Akt,NF-κB,STAT","JAK/STAT","Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.",462.36,"27740-01-8",{"v":50,"d":"50.00"},108.14,"N/A","N/A","http://selleckchem.com/products/scutellarin.html","C21H18O12","free base","Breviscapine, Breviscapin, Scutellarein-7-glucuronide","OC1C(O)C(OC(C1O)C(O)=O)OC2=CC3=C(C(=O)C=C(O3)C4=CC=C(O)C=C4)C(=C2O)O",0.366,5,6,4]
["S3811","Ginsenoside Re","h9","L3000-15","in 10mM DMSO","Beta Amyloid,JNK,NF-κB","Neuronal Signaling","Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.",947.15,"52286-59-6",{"v":100,"d":"100.00"},105.58,"N/A","N/A","http://selleckchem.com/products/ginsenoside-re.html","C48H82O18","free base","Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc","CC1OC(OC2C(O)C(O)C(CO)OC2OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C1O",0.267,6,12,12]
["S3812","Monocrotaline","a10","L3000-15","in 10mM DMSO","Others","Others","Monocrotaline (MCT, Crotaline) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale.",325.36,"315-22-0",{"v":65,"d":"65.00"},199.78,"N/A","N/A","http://selleckchem.com/products/monocrotaline.html","C16H23NO6","free base","Crotaline","CC1C(=O)OC2CCN3CC=C(COC(=O)C(C)(O)C1(C)O)C23",-0.015,4,0,0]
["S3813","Bakuchiol","b10","L3000-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.",256.38,"10309-37-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/bakuchiol.html","C18H24O","free base","(S)-(+)-Bakuchiol","CC(C)=CCCC(C)(C=C)\\C=C\\C1=CC=C(O)C=C1",5.348,0,1,6]
["S3814","Tubeimoside I","c10","L3000-15","in 10mM DMSO","Apoptosis related","Apoptosis","Tubeimoside I (Lobatoside H, TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects.",1319.43,"102040-03-9",{"v":100,"d":"100.00"},268.55,"N/A","N/A","http://selleckchem.com/products/tubeimoside-i.html","C63H98O29","free base","Lobatoside H","CC1OC(OC2C(O)C(O)COC2OC(=O)C34CCC(C)(C)CC3C5=CCC6C7(C)CC(O)C8OC9OC(CO)C(O)C(O)C9OC%10OCC(O)C(O)C%10OC(=O)CC(C)(O)CC(=O)OCC8(C)C7CCC6(C)C5(C)CC4)C(O)C(OC%11OCC(O)C(O)C%11O)C1O",-1.606,15,13,8]
["S3815","Mogroside V","d10","L3000-15","in 10mM DMSO","Others","Others","Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).",1287.43,"88901-36-4",{"v":100,"d":"100.00"},77.67,"N/A","N/A","http://selleckchem.com/products/mogroside-v.html","C60H102O29","free base","N/A","CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1OC3OC(CO)C(O)C(O)C3O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C",{"v":-3.98,"d":"-3.980"},10,18,20]
["S3817","Harmine hydrochloride","e10","L3000-15","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,DYRK,MAO","Cell Cycle","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",248.71,"343-27-1",{"v":21,"d":"21.00"},84.44,"N/A","N/A","http://selleckchem.com/products/harmine-hydrochloride.html","C13H12N2O.HCl","hydrochloride","Telepathine hydrochloride","Cl.COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",{"v":2.82,"d":"2.820"},2,1,1]
["S3818","Tectoridin","f10","L3000-15","in 10mM DMSO","Others","Others","Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.",{"v":462.4,"d":"462.40"},"611-40-5",{"v":92,"d":"92.00"},198.96,"N/A","N/A","http://selleckchem.com/products/tectoridin.html","C22H22O11","free base","Shekanin","COC1=C(O)C2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1OC4OC(CO)C(O)C(O)C4O",0.194,5,6,5]
["S3819","Decursinol angelate","g10","L3000-15","in 10mM DMSO","PKC","Cytoskeletal Signaling","Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.",328.36,"130848-06-5",{"v":65,"d":"65.00"},197.95,"N/A","N/A","http://selleckchem.com/products/decursinol-angelate.html","C19H20O5","free base","N/A","C\\C=C(C)/C(=O)OC1CC2=CC3=C(OC(=O)C=C3)C=C2OC1(C)C",3.955,5,0,3]
["S3822","Schisandrin A","h10","L3000-15","in 10mM DMSO","AdipoR","Metabolism","Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.",416.51,"61281-38-7",{"v":83,"d":"83.00"},199.27,"N/A","N/A","http://selleckchem.com/products/schisandrin-a.html","C24H32O6","free base","Deoxyschizandrin, Wuweizisu A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C(OC)C(=C3OC)OC",5.266,6,0,6]
["S3823","Schizandrol A","a11","L3000-15","in 10mM DMSO","Others","Neuronal Signaling","Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.",432.51,"7432-28-2",{"v":86,"d":"86.00"},198.84,"N/A","N/A","http://selleckchem.com/products/schizandrol-a.html","C24H32O7","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)(O)C(C)C2)C=C(OC)C(=C3OC)OC",{"v":4.05,"d":"4.050"},6,0,6]
["S3825","Glycitin","b11","L3000-15","in 10mM DMSO","Others","Others","Glycitin (Glycitein-7-β-O-glucoside), a natural isoflavone isolated from legumes, has antibacterial, antiviral and estrogenic activities and may exerts preventative effects on alcoholism, cardiovascular and cerebrovascular diseases and some types of cancer.",{"v":446.4,"d":"446.40"},"40246-10-4",{"v":89,"d":"89.00"},199.37,"N/A","N/A","http://selleckchem.com/products/glycitin.html","C22H22O10","free base","Glycitein-7-β-O-glucoside","COC1=CC2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1OC4OC(CO)C(O)C(O)C4O",0.436,5,5,5]
["S3826","Hydroxytyrosol","c11","L3000-15","in 10mM DMSO","Others","Others","Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities.",154.16,"10597-60-1",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol.html","C8H10O3","free base","3-Hydroxytyrosol; 3,4-dihydroxyphenylethanol; Dihydroxyphenylethanol; 2-(3,4-Di-hydroxyphenyl)-ethanol","OCCC1=CC=C(O)C(=C1)O",1.062,0,3,2]
["S3829","Isoalantolactone","d11","L3000-15","in 10mM DMSO","Apoptosis related,Fungal","Apoptosis","Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia.  Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.",232.32,"470-17-7",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"N/A","N/A","http://selleckchem.com/products/isoalantolactone.html","C15H20O2","Sesquiterpene lactone","N/A","CC12CCCC(=C)C1CC3C(C2)OC(=O)C3=C",3.365,2,0,0]
["S3832","Euphorbiasteroid","e11","L3000-15","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Euphorbiasteroid (Euphorbia factor L1), a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway and induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a dose-dependent manner. Euphorbiasteroid is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect.",552.66,"28649-59-4",{"v":21,"d":"21.00"},{"v":38,"d":"38.00"},"N/A","N/A","http://selleckchem.com/products/euphorbiasteroid.html","C32H40O8","free base","Euphorbia factor L1","CC1CC2(OC(C)=O)C(C1OC(=O)CC3=CC=CC=C3)C(OC(C)=O)C4(CCC5C(\\C=C(C)\\C2=O)C5(C)C)CO4",4.183,8,0,8]
["S3833","Amentoflavone","f11","L3000-15","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.",538.46,"1617-53-4",{"v":100,"d":"100.00"},185.71,"N/A","N/A","http://selleckchem.com/products/amentoflavone.html","C30H18O10","free base","Didemethyl Ginkgetin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(O)C=C3O)C4=CC(=CC=C4O)C5=CC(=O)C6=C(O5)C=C(O)C=C6O",4.509,4,6,3]
["S3835","Loganin","g11","L3000-15","in 10mM DMSO","AChR,BACE,BChE","Neuronal Signaling","Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.",390.38,"18524-94-2",{"v":78,"d":"78.00"},199.81,"N/A","N/A","http://selleckchem.com/products/loganin.html","C17H26O10","free base","Loganoside","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)C(O)CC13",-1.895,5,5,5]
["S3836","6-Gingerol","h11","L3000-15","in 10mM DMSO","Apoptosis related","Apoptosis","6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.",294.39,"23513-14-6",{"v":58,"d":"58.00"},197.02,"N/A","N/A","http://selleckchem.com/products/6-gingerol.html","C17H26O4","free base","N/A","CCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",3.638,2,2,10]
["S3837","Echinocystic acid","a2","L3000-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.",{"v":472.7,"d":"472.70"},"510-30-5",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/echinocystic-acid.html","C30H48O4","free base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",5.345,1,2,1]
["S3838","Carnosic acid","b2","L3000-16","in 10mM DMSO","ROS","Immunology & Inflammation","Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.",332.43,"3650-09-7",{"v":66,"d":"66.00"},198.54,"N/A","N/A","http://selleckchem.com/products/carnosic-acid.html","C20H28O4","free base","Salvin","CC(C)C1=CC2=C(C(=C1O)O)C3(CCCC(C)(C)C3CC2)C(O)=O",4.905,1,2,2]
["S3840","Baohuoside I","c2","L3000-16","in 10mM DMSO","ROS","Immunology & Inflammation","Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.",514.52,"113558-15-9",{"v":100,"d":"100.00"},194.36,"N/A","N/A","http://selleckchem.com/products/baohuoside-i.html","C27H30O10","Flavonoid glycoside","Icariside II","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O)C=C(O)C(=C4O2)CC=C(C)C",2.913,5,5,6]
["S3841","Eleutheroside B","d2","L3000-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.",372.37,"118-34-3",{"v":74,"d":"74.00"},198.73,"N/A","N/A","http://selleckchem.com/products/eleutheroside-b.html","C17H24O9","free base","syringin, Syringoside, Lilacin","COC1=CC(=CC(=C1OC2OC(CO)C(O)C(O)C2O)OC)\\C=C\\CO",-0.512,4,5,7]
["S3842","Isoquercitrin","e2","L3000-16","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.",464.38,"482-35-9",{"v":92,"d":"92.00"},198.11,"N/A","N/A","http://selleckchem.com/products/isoquercitrin.html","C21H20O12","free base","Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside","OCC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S3844","Rosavin","f2","L3000-16","in 10mM DMSO","Others","Others","Rosavin, a cinnamyl alcohol glycoside found in the plant Rhodiola rosea, possesses antidepressant and anxiolytic activities.",428.43,"84954-92-7",{"v":85,"d":"85.00"},{"v":198.4,"d":"198.40"},"N/A","N/A","http://selleckchem.com/products/rosavin.html","C20H28O10","free base","N/A","OC1COC(OCC2OC(OC\\C=C\\C3=CC=CC=C3)C(O)C(O)C2O)C(O)C1O",{"v":-1.29,"d":"-1.290"},4,6,7]
["S3846","Eupatilin","g2","L3000-16","in 10mM DMSO","PPAR","Metabolism","Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.",344.32,"22368-21-4",{"v":68,"d":"68.00"},197.49,"N/A","N/A","http://selleckchem.com/products/eupatilin.html","C18H16O7","free base","NSC 122413","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)OC",2.603,5,2,4]
["S3847","Panaxatriol","h2","L3000-16","in 10mM DMSO","Others","Others","Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.",476.73,"32791-84-7",{"v":95,"d":"95.00"},199.27,"N/A","N/A","http://selleckchem.com/products/panaxatriol.html","C30H52O4","free base","N/A","CC1(C)CCCC(C)(O1)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(O)CC34C",4.285,1,3,1]
["S3849","D-Galactose","a3","L3000-16","in 10mM DMSO","Others","Others","D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.",180.16,"59-23-4",{"v":36,"d":"36.00"},199.82,"N/A","N/A","http://selleckchem.com/products/d-galactose.html","C6H12O6","free base","D-Galactopyranose, D-(+)-Galactose","OCC1OC(O)C(O)C(O)C1O",-2.514,1,4,1]
["S3850","Glucosamine sulfate","b3","L3000-16","in 10mM DMSO","Others","Others","Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.",277.25,"29031-19-4",{"v":4,"d":"4.00"},14.43,{"v":55,"d":"55.00"},198.38,"http://selleckchem.com/products/glucosamine-sulfate.html","C6H13NO5.H2SO4","sulfate","D-Glucosaminesulfate, D-Glucosamine sulphate","NC(C=O)C(O)C(O)C(O)CO.O[S](O)(=O)=O",-3.688,1,5,5]
["S3851","Camphor","c3","L3000-16","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.",152.23,"76-22-2",{"v":30,"d":"30.00"},197.07,"N/A","N/A","http://selleckchem.com/products/camphor.html","C10H16O","free base","2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa","CC1(C)C2CCC1(C)C(=O)C2",2.075,1,0,0]
["S3853","Perillyl alcohol","d3","L3000-16","in 10mM DMSO","Ras","Apoptosis","Perillyl alcohol (Perilla alcohol, Isocarveol) is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants.",152.23,"536-59-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/perillyl-alcohol.html","C10H16O","free base","Perilla alcohol, Isocarveol","CC(=C)C1CCC(=CC1)CO",2.411,0,1,2]
["S3856","Allantoin","e3","L3000-16","in 10mM DMSO","Others","Others","Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.",158.12,"97-59-6",{"v":7,"d":"7.00"},44.27,"N/A","N/A","http://selleckchem.com/products/allantoin.html","C4H6N4O3","free base","Glyoxyldiureide, 5-Ureidohydantoin","NC(=O)NC1NC(=O)NC1=O",{"v":-1.76,"d":"-1.760"},3,4,1]
["S3857","4-Hydroxybenzyl alcohol","f3","L3000-16","in 10mM DMSO","Apoptosis related","Apoptosis","4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.",124.14,"623-05-2",{"v":24,"d":"24.00"},193.33,"N/A","N/A","http://selleckchem.com/products/4-hydroxybenzyl-alcohol.html","C7H8O2","free base","P-Methylolphenol, 4-Methylolphenol","OCC1=CC=C(O)C=C1",0.983,0,2,1]
["S3860","Allicin","g3","L3000-16","in 10mM DMSO","Fungal","Metabolism","Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.",162.27,"539-86-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/allicin.html","C6H10OS2","free base","diallyl thiosulfinate","C=CCS[S](=O)CC=C",2.005,1,0,5]
["S3867","(E)-Cardamonin","h3","L3000-16","in 10mM DMSO","NF-κB,TRP Channel","NF-κB","(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.",270.28,"19309-14-9",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/e-cardamoni.html","C16H14O4","free base","Alpinetin chalcone, cardamomin","COC1=CC(=CC(=C1C(=O)\\C=C\\C2=CC=CC=C2)O)O",3.201,2,2,4]
["S3868","Harmine","a4","L3000-16","in 10mM DMSO","MAO,PPAR","Metabolism","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",212.25,"442-51-3",{"v":42,"d":"42.00"},197.88,"N/A","N/A","http://selleckchem.com/products/harmine.html","C13H12N2O","free base","Telepathine","COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",2.438,2,1,1]
["S3869","Methyl protocatechuate","b4","L3000-16","in 10mM DMSO","Others","Others","Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.",168.15,"2150-43-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/methyl-protocatechuate.html","C8H8O4","free base","Methyl 3,4-dihydroxybenzoate; 3,4-Dihydroxybenzoic acid methyl ester; Protocatechuic Acid Methyl Ester","COC(=O)C1=CC(=C(O)C=C1)O",1.201,2,2,2]
["S3870","D-Pinitol","c4","L3000-16","in 10mM DMSO","Influenza Virus","Microbiology","D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.",194.18,"10284-63-6",{"v":38,"d":"38.00"},195.69,"N/A","N/A","http://selleckchem.com/products/d-pinitol.html","C7H14O6","free base","Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol","COC1C(O)C(O)C(O)C(O)C1O",-2.656,1,5,1]
["S3871","Muscone","d4","L3000-16","in 10mM DMSO","Immunology & Inflammation related,Interleukins,NF-κB,NLRP3,TNF-alpha","NF-κB","Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).",238.41,"541-91-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/muscone.html","C16H30O","free base","3-Methylcyclopentadecanone, Methylexaltone","CC1CCCCCCCCCCCCC(=O)C1",5.672,1,0,0]
["S3874","Curcumenol","e4","L3000-16","in 10mM DMSO","NF-κB,P450 (e.g. CYP17)","NF-κB","Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.",234.33,"19431-84-6",{"v":46,"d":"46.00"},{"v":196.3,"d":"196.30"},"N/A","N/A","http://selleckchem.com/products/curcumenol.html","C15H22O2","free base","N/A","CC1CCC2C(=CC3(O)OC12CC3=C(C)C)C",3.268,1,0,0]
["S3875","Alpinetin","f4","L3000-16","in 10mM DMSO","PPAR","Metabolism","Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities.  Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.",270.28,"36052-37-6",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/alpinetin.html","C16H14O4","free base","N/A","COC1=CC(=CC2=C1C(=O)CC(O2)C3=CC=CC=C3)O",2.841,3,1,2]
["S3876","Indigo","g4","L3000-16","in 10mM DMSO","Dyes","Others","Indigo (Indigotin) dye is an organic compound with a distinctive blue color. It is extracted from the leaves of certain plants or synthetic.",262.26,"482-89-3",{"v":33,"d":"33.00"},125.83,"N/A","N/A","http://selleckchem.com/products/indigo.html","C16H10N2O2","free base","Indigotin","O=C1\\C(NC2=C1C=CC=C2)=C\\3NC4=C(C=CC=C4)C3=O",2.106,2,2,0]
["S3878","Bavachinin","h4","L3000-16","in 10mM DMSO","PPAR","Metabolism","Bavachinin (7-O-Methylbavachin) is a novel natural pan-PPAR agonist from the fruit of the traditional Chinese glucose-lowering herb malaytea scurfpea. It shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively).",{"v":338.4,"d":"338.40"},"19879-30-2",{"v":67,"d":"67.00"},197.99,"N/A","N/A","http://selleckchem.com/products/bavachinin.html","C21H22O4","free base","7-O-Methylbavachin","COC1=CC2=C(C=C1CC=C(C)C)C(=O)CC(O2)C3=CC=C(O)C=C3",4.698,3,1,4]
["S3879","Kaempferide","a5","L3000-16","in 10mM DMSO","EGFR","Apoptosis","Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether), a natural compound derived from the roots of kaempferia galanga, has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.",300.26,"491-54-3",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://selleckchem.com/products/kaempferide.html","C16H12O6","free base","4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",2.098,3,3,2]
["S3882","Brassinolide","b5","L3000-16","in 10mM DMSO","Others","Others","Brassinolide, a plant steroid isolated from Brassica napus pollen, promotes cell elongation and cell devision and thus regulates plant growth and development.",480.68,"72962-43-7",{"v":96,"d":"96.00"},199.72,"<1","N/A","http://selleckchem.com/products/brassinolide.html","C28H48O6","free base","N/A","CC(C)C(C)C(O)C(O)C(C)C1CCC2C3COC(=O)C4CC(O)C(O)CC4(C)C3CCC12C",3.572,2,4,5]
["S3883","Protopine","c5","L3000-16","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.",353.37,"130-86-9",{"v":30,"d":"30.00"},{"v":84.9,"d":"84.90"},"N/A","N/A","http://selleckchem.com/products/protopine.html","C20H19NO5","free base","Corydinine, Fumarine, Biflorine, Macleyine","CN1CCC2=C(C=C3OCOC3=C2)C(=O)CC4=C(C1)C5=C(OCO5)C=C4",2.953,5,0,0]
["S3884","Jatrorrhizine","d5","L3000-16","in 10mM DMSO","AChR","Neuronal Signaling","Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.",338.38,"3621-38-3",{"v":67,"d":"67.00"},{"v":198,"d":"198.00"},"N/A","N/A","http://selleckchem.com/products/jatrorrhizine.html","C20H20NO4","free base","Neprotin, Yatrorizine","COC1=CC2=C(CC[N+]3=CC4=C(C=CC(=C4OC)OC)C=C23)C=C1O",3.936,3,1,3]
["S3885","Pyrogallol","e5","L3000-16","in 10mM DMSO","ROS","Immunology & Inflammation","Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.",126.11,"87-66-1",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/pyrogallol.html","C6H6O3","free base","1,2,3-trihydroxybenzene","OC1=C(O)C(=CC=C1)O",1.103,0,3,0]
["S3887","α-L-Rhamnose monohydrate","f5","L3000-16","in 10mM DMSO","Others","Others","α-L-Rhamnose monohydrate (6-deoxy-L-mannose monohydrate, α-L-Rhamnopyranose monohydrate) is used as a starting material for the production of furanones. It is an important material involved in the reaction of flavors developed during the preparation of various foods like bread, grilled meats, etc.",182.17,"6155-35-7",{"v":36,"d":"36.00"},197.62,"N/A","N/A","https://www.selleckchem.com/products/a-l-rhamnose-monohydrate.html","C6H12O5.H2O","hydrate","6-deoxy-L-mannose monohydrate, α-L-Rhamnopyranose monohydrate","O.CC1OC(O)C(O)C(O)C1O",-1.833,1,3,0]
["S3888","3,4',5-Trimethoxy-trans-stilbene","g5","L3000-16","in 10mM DMSO","p38 MAPK","Apoptosis","3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.",270.32,"22255-22-7",{"v":54,"d":"54.00"},199.76,"N/A","N/A","http://selleckchem.com/products/3-4-5-trimethoxy-trans-stilbene.html","C17H18O3","free base","MR-3","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC",3.766,3,0,5]
["S3889","Arteether","h5","L3000-16","in 10mM DMSO","Parasite","Microbiology","Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.",{"v":312.4,"d":"312.40"},"75887-54-6",{"v":62,"d":"62.00"},198.46,"N/A","N/A","http://selleckchem.com/products/arteether.html","C17H28O5","free base","N/A","CCOC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3",2.378,5,0,2]
["S3892","Isopsoralen","a6","L3000-16","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.",186.16,"523-50-2",{"v":14,"d":"14.00"},{"v":75.2,"d":"75.20"},"N/A","N/A","http://selleckchem.com/products/isopsoralen.html","C11H6O3","free base","angelicin","O=C1OC2=C(C=C1)C=CC3=C2C=CO3",2.203,3,0,0]
["S3893","Bornyl acetate","b6","L3000-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.",196.29,"76-49-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/bornyl-acetate.html","C12H20O2","free base","Isobornyl acetate, Bornyl acetic ether, 2-Camphanol acetate","CC(=O)OC1CC2CCC1(C)C2(C)C",2.354,2,0,2]
["S3894","Cycloastragenol","c6","L3000-16","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.",490.72,"84605-18-5",{"v":98,"d":"98.00"},199.71,"N/A","N/A","http://selleckchem.com/products/cycloastragenol.html","C30H50O5","free base","CAG, TA-65, Cyclogalegigenin, Astramembrangenin","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(O)CCC56CC46CCC23C",2.635,1,3,2]
["S3895","Sophoridine","d6","L3000-16","in 10mM DMSO","Apoptosis related","Apoptosis","Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.",248.36,"6882-68-4",{"v":49,"d":"49.00"},197.29,"N/A","N/A","http://selleckchem.com/products/sophoridine.html","C15H24N2O","free base","5-Epidihydrosophocarpine, Dihydro-5-episophocarpine","O=C1CCCC2C3CCCN4CCCC(CN12)C34",1.417,1,0,0]
["S3896","(1R,2R)-trans-N-Boc-1,2-cyclohexanediamine","e6","L3000-16","in 10mM DMSO","Others","Others","(1R,2R)-trans-N-Boc-1,2-cyclohexanediamine is an intermediate in organic synthesis.",{"v":214.3,"d":"214.30"},"146504-07-6",{"v":42,"d":"42.00"},195.99,"N/A","N/A","http://selleckchem.com/products/1r-2r-trans-n-boc-1-2-cyclohexanediamine.html","C11H22N2O2","free base","N/A","CC(C)(C)OC(=O)NC1CCCCC1N",{"v":1.55,"d":"1.550"},2,2,3]
["S3897","(-)-Arctigenin","f6","L3000-16","in 10mM DMSO","Influenza Virus","Microbiology","(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.",372.41,"7770-78-7",{"v":74,"d":"74.00"},198.71,"N/A","N/A","http://selleckchem.com/products/neg-rotation-arctigenin.html","C21H24O6","free base","N/A","COC1=C(O)C=CC(=C1)CC2C(COC2=O)CC3=CC=C(OC)C(=C3)OC",3.743,5,1,7]
["S3898","Hydroxy Camptothecine","g6","L3000-16","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.",364.35,"64439-81-2",{"v":29,"d":"29.00"},79.59,"N/A","N/A","http://selleckchem.com/products/hydroxy-camptothecine.html","C20H16N2O5","free base","10-Hydroxycamptothecin, Hydroxycamptothecine","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=C(C=CC(=C5)O)N=C34)C2=O",1.504,4,1,1]
["S3899","Hederagenin","h6","L3000-16","in 10mM DMSO","COX,NF-κB,NOS","Immunology & Inflammation","Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB.",{"v":472.7,"d":"472.70"},"465-99-6",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hederagenin.html","C30H48O4","free base","Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1)C(O)=O",5.356,1,2,2]
["S3900","Betulonic acid","a7","L3000-16","in 10mM DMSO","Others","Others","Betulonic acid (Liquidambaric acid), derived from betulinol, a pentacyclic styrene, has shown a highly specific anti-prostate cancer activity in in vitro cell cultures.",454.68,"4481-62-3",{"v":21,"d":"21.00"},46.19,"N/A","N/A","http://selleckchem.com/products/betulonic-acid.html","C30H46O3","free base","Liquidambaric acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C12)C(O)=O",6.647,2,0,2]
["S3901","Astragaloside IV","b7","L3000-16","in 10mM DMSO","Akt,ERK,JNK,mTOR,NF-κB","MAPK","Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-Akt, p-mTOR, p-NF-κB and p-Erk1/2.",784.97,"84687-43-4",{"v":100,"d":"100.00"},127.39,"N/A","N/A","http://selleckchem.com/products/sastragaloside-iv.html","C41H68O14","free base","AST-IV, AS-IV","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O",-0.348,5,8,7]
["S3902","Ursonic acid","c7","L3000-16","in 10mM DMSO","Others","Apoptosis","Ursonic acid (Prunol, Malol, beta-Ursolic acid, NSC4060, CCRIS 7123, TOS-BB-0966), present in many plants, is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents. Ursonic acid induces the apoptosis of human cancer cells through multiple signaling pathways.",454.68,"6246-46-4",{"v":30,"d":"30.00"},65.98,"N/A","N/A","http://selleckchem.com/products/ursonic-acid.html","C30H46O3","free base","Prunol, Malol, beta-Ursolic acid, NSC4060, CCRIS 7123, TOS-BB-0966, 3-beta-hydroxyurs-12-en-28-oic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",6.593,2,0,1]
["S3903","Lycorine","d7","L3000-16","in 10mM DMSO","AChR","Neuronal Signaling","Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.",287.31,"476-28-8",{"v":57,"d":"57.00"},198.39,"N/A","N/A","http://selleckchem.com/products/lycorine.html","C16H17NO4","free base","Galanthidine, Amarylline, Narcissine, Licorine, Belamarine","OC1C=C2CCN3CC4=CC5=C(OCO5)C=C4C(C1O)C23",0.713,2,2,0]
["S3904","Isoimperatorin","e7","L3000-16","in 10mM DMSO","AChR","Neuronal Signaling","Isoimperatorin, a natural furanocoumarin that can be isolated from a variety of plant parts, has analgesic, antimicrobial, vascular relaxing and anticancer activities.  Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM.",270.28,"482-45-1",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/isoimperatorin.html","C16H14O4","free base","N/A","CC(C)=CCOC1=C2C=COC2=CC3=C1C=CC(=O)O3",3.652,4,0,3]
["S3905","Iso-Steviol","f7","L3000-16","in 10mM DMSO","Others","Others","Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects.",318.45,"27975-19-5",{"v":63,"d":"63.00"},197.83,"N/A","N/A","http://selleckchem.com/products/iso-steviol.html","C20H30O3","free base","N/A","CC12CCC3C4(C)CCCC(C)(C4CCC3(CC1=O)C2)C(O)=O",3.924,2,0,1]
["S3908","4'-Demethylpodophyllotoxin","g7","L3000-16","in 10mM DMSO","Others","Others","4'-Demethylpodophyllotoxin is isolated from the herb of Dysosma pleiantha (Hance) Woodson with remarkable cytotoxic potential in diverse cancer cell lines.",400.38,"40505-27-9",{"v":80,"d":"80.00"},199.81,"N/A","N/A","http://selleckchem.com/products/4-demethylpodophyllotoxin.html","C21H20O8","free base","N/A","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(O)C4=C2C=C5OCOC5=C4",1.886,6,2,3]
["S3911","Veratramine","h7","L3000-16","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.",{"v":409.6,"d":"409.60"},"60-70-8",{"v":63,"d":"63.00"},153.81,"N/A","N/A","http://selleckchem.com/products/veratramine.html","C27H39NO2","free base","NSC 17821, NSC 23880","CC1CNC(C(O)C1)C(C)C2=CC=C3C4CC=C5CC(O)CCC5(C)C4CC3=C2C",4.657,0,3,2]
["S3912","Cephalotaxine","a8","L3000-16","in 10mM DMSO","Others","Others","Cephalotaxine is a naturally occurring alkaloid which is the structural motif of a number of compounds and has shown promising anti-cancer properties.",315.36,"24316-19-6",{"v":52,"d":"52.00"},164.89,"N/A","N/A","http://selleckchem.com/products/cephalotaxine.html","C18H21NO4","free base","N/A","COC1=CC23CCCN2CCC4=CC5=C(OCO5)C=C4C3C1O",1.515,3,1,1]
["S3914","α-Hederin","b8","L3000-16","in 10mM DMSO","Others","Apoptosis","α-hederin is a water-soluble pentacyclic triterpenoid saponin which has shown hemolytic and apoptotic properties.",750.96,"27013-91-8",{"v":100,"d":"100.00"},133.16,"N/A","N/A","http://selleckchem.com/products/alpha-hederin.html","C41H66O12","free base","N/A","CC1OC(OC2C(O)C(O)COC2OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(O)=O)C3(C)CO)C(O)C(O)C1O",3.261,5,6,6]
["S3915","Gracillin","c8","L3000-16","in 10mM DMSO","Others","Others","Gracillin, a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica, has been reported to exert antitumor activity.",885.04,"19083-00-2",{"v":100,"d":"100.00"},112.99,"N/A","N/A","http://selleckchem.com/products/gracillin.html","C45H72O17","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C7OC9OC(C)C(O)C(O)C9O",0.281,8,9,8]
["S3916","Macranthoidin B","d8","L3000-16","in 10mM DMSO","Others","Others","Macranthoidin B (Macranthoiside I) is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.",1399.52,"136849-88-2",{"v":59,"d":"59.00"},42.16,"N/A","N/A","http://selleckchem.com/products/macranthoidin-b.html","C65H106O32","free base","Macranthoiside I","CC1OC(OC2C(O)C(O)COC2OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(=O)OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C3(C)CO)C(O)C(OC%10OC(CO)C(OC%11OC(CO)C(O)C(O)C%11O)C(O)C%10O)C1O",-3.909,13,19,18]
["S3917","Tetrahydrocurcumin","e8","L3000-16","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties.  Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.",372.41,"36062-04-1",{"v":74,"d":"74.00"},{"v":198.7,"d":"198.70"},"<1","N/A","https://www.selleckchem.com/products/tetrahydrocurcumin.html","C21H24O6","free base","Tetrahydrodiferuloylmethane, Tetrahydro Curcumin","COC1=C(O)C=CC(=C1)CCC(=O)CC(=O)CCC2=CC=C(O)C(=C2)OC",-0.415,9,13,12]
["S3921","Lathyrol","f8","L3000-16","in 10mM DMSO","Others","Others","Lathyrol is a natural product that is used for cancer treatment.",334.45,"34420-19-4",{"v":85,"d":"85.00"},254.15,"N/A","N/A","http://selleckchem.com/products/lathyrol.html","C20H30O4","free base","N/A","CC1CC2(O)C(C1O)C(O)C(=C)CCC3C(\\C=C(C)\\C2=O)C3(C)C",2.421,1,2,0]
["S3922","(-)-epigallocatechin","g8","L3000-16","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.",306.27,"970-74-1",{"v":61,"d":"61.00"},199.17,"N/A","N/A","http://selleckchem.com/products/neg-rotation-epigallocatechin.html","C15H14O7","free base","N/A","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S3923","Ginsenoside Rg1","h8","L3000-16","in 10mM DMSO","Beta Amyloid,NF-κB","Neuronal Signaling","Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. Ginsenoside Rg1 reduces cerebral Aβ levels and NF-κB nuclear translocation.",801.01,"22427-39-0",{"v":100,"d":"100.00"},124.84,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rg1.html","C42H72O14","free base","Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(CO)C(O)C(O)C6O",1.126,4,10,10]
["S3924","Ginsenoside Rb1","a9","L3000-16","in 10mM DMSO","ATPase,IFN,IRAK,NF-κB,NOS,TLR,TNF-alpha","Transmembrane Transporters","Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.",1109.29,"41753-43-9",{"v":100,"d":"100.00"},90.15,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rb1.html","C54H92O23","free base","Gypenoside Ⅲ","CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-1.198,8,15,16]
["S3925","(-)-Epicatechin gallate","b9","L3000-16","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,"N/A","N/A","http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3926","Forsythin","c9","L3000-16","in 10mM DMSO","PDE","GPCR & G Protein","Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties.",534.55,"487-41-2",{"v":100,"d":"100.00"},187.07,"N/A","N/A","http://selleckchem.com/products/forsythin.html","C27H34O11","free base","Phillyrin","COC1=CC=C(C=C1OC)C2OCC3C2COC3C4=CC(=C(OC5OC(CO)C(O)C(O)C5O)C=C4)OC",0.479,7,4,8]
["S3927","Swertiamarin","d9","L3000-16","in 10mM DMSO","Others","Others","Swertiamarin (Swertiamaroside) is a common secoiridoid found among the members of Gentianaceae with anti-inflammatory, anticancer, hypoglycemic and hypolipidemic activities.",374.34,"17388-39-5",{"v":74,"d":"74.00"},197.68,"N/A","N/A","http://selleckchem.com/products/swertiamarin.html","C16H22O10","free base","Swertiamaroside","OCC1OC(OC2OC=C3C(=O)OCCC3(O)C2C=C)C(O)C(O)C1O",-2.381,5,4,4]
["S3928","Baccatin Ⅲ","e9","L3000-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities.",586.63,"27548-93-2",{"v":100,"d":"100.00"},170.47,"N/A","N/A","http://selleckchem.com/products/Baccatin-iii.html","C31H38O11","free base","N/A","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(O)C(=C1C5(C)C)C",0.743,8,2,7]
["S3929","Liquiritigenin","f9","L3000-16","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Liquiritigenin (4',7-Dihydroxyflavanone), the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.",256.25,"578-86-9",{"v":51,"d":"51.00"},199.02,"N/A","N/A","http://selleckchem.com/products/liquiritigenin.html","C15H12O4","free base","4',7-Dihydroxyflavanone","OC1=CC=C(C=C1)C2CC(=O)C3=CC=C(O)C=C3O2",2.615,2,2,1]
["S3930","Liquiritin","g9","L3000-16","in 10mM DMSO","AKR1C","Immunology & Inflammation","Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.",418.39,"551-15-5",{"v":100,"d":"100.00"},239.01,"N/A","N/A","http://selleckchem.com/products/liquiritin.html","C21H22O9","free base","Liquiritoside, Liquiritigenin-4'-O-glucoside","OCC1OC(OC2=CC=C(C=C2)C3CC(=O)C4=C(O3)C=C(O)C=C4)C(O)C(O)C1O",0.686,4,5,4]
["S3931","Ginsenoside Rd","h9","L3000-16","in 10mM DMSO","Calcium Channel,COX,NF-κB,NOS,P450 (e.g. CYP17)","Immunology & Inflammation","Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.",947.15,"52705-93-8",{"v":90,"d":"90.00"},95.02,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rd.html","C48H82O18","free base","Panaxoside Rd, Sanchinoside Rd","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C(C)(C)C5CCC34C",0.548,6,12,13]
["S3932","Astilbin","a10","L3000-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.",450.39,"29838-67-3",{"v":100,"d":"100.00"},222.03,"N/A","N/A","http://selleckchem.com/products/astilbin.html","C21H22O11","free base","Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside","CC1OC(OC2C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.621,4,7,3]
["S3934","Acetyl Resveratrol","b10","L3000-16","in 10mM DMSO","Others","Others","Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.",354.35,"42206-94-0",{"v":70,"d":"70.00"},197.54,"<1","N/A","https://www.selleckchem.com/products/acetyl-resveratrol.html","C20H18O6","free base","N/A","CC(=O)OC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC(C)=O)OC(C)=O",3.119,6,0,8]
["S3935","Nonivamide","c10","L3000-16","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Nonivamide (pelargonic acid vanillylamide, Pseudocapsaicin, Vanillyl-N-nonylamide), present in chili peppers, is commonly manufactured synthetically and used as a food additive to add pungency to seasonings, flavorings, and spice blends. Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.",{"v":293.4,"d":"293.40"},"2444-46-4",{"v":58,"d":"58.00"},197.68,"<1","N/A","https://www.selleckchem.com/products/nonivamide.html","C17H27NO3","free base","pelargonic acid vanillylamide, Pseudocapsaicin, Vanillyl-N-nonylamide","CCCCCCCCC(=O)NCC1=CC(=C(O)C=C1)OC",4.103,2,2,10]
["S3937","Pterostilbene","d10","L3000-16","in 10mM DMSO","Others","Others","Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.",{"v":256.3,"d":"256.30"},"537-42-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/pterostilbene.html","C16H16O3","free base","N/A","COC1=CC(=CC(=C1)\\C=C\\C2=CC=C(O)C=C2)OC",3.541,2,1,4]
["S3938","Bisdemethoxycurcumin (BDMC)","e10","L3000-16","in 10mM DMSO","Apoptosis related","Apoptosis","Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.",308.33,"33171-05-0",{"v":62,"d":"62.00"},201.08,"<1","N/A","http://selleckchem.com/products/bisdemethoxycurcumin.html","C19H16O4","free base","N/A","OC1=CC=C(C=C1)/C=C/C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",3.587,2,2,6]
["S3940","3'-Hydroxypterostilbene","f10","L3000-16","in 10mM DMSO","ERK,JNK,p38 MAPK,S6 Kinase","MAPK","3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.",{"v":272.3,"d":"272.30"},"475231-21-1",{"v":54,"d":"54.00"},198.31,"<1","N/A","http://selleckchem.com/products/3-hydroxypterostilbene.html","C16H16O4","free base","3'-HPT","COC1=CC(=CC(=C1)/C=C/C2=CC(=C(O)C=C2)O)OC",3.299,2,2,4]
["S3941","Pinocembrin","g10","L3000-16","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.",256.25,"480-39-7",{"v":51,"d":"51.00"},199.02,"<1","N/A","http://selleckchem.com/products/pinocembrin.html","C15H12O4","free base","Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone","OC1=CC2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O",2.615,2,2,1]
["S3942","Cardamonin","h10","L3000-16","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.",270.28,"18956-16-6",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/cardamonin.html","C16H14O4","free base","Alpinetin chalcone","COC1=CC(=CC(=C1C(=O)C=CC2=CC=CC=C2)O)O",3.201,2,2,4]
["S3944","Valproic acid (VPA)","a11","L3000-16","in 10mM DMSO","Autophagy,HDAC,Mitophagy,Notch,PGC-1α","Epigenetics","Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.",144.21,"99-66-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/valproic-acid.html","C8H16O2","free base","2-Propylvaleric Acid, Valproate","CCCC(CCC)C(O)=O",2.749,1,0,5]
["S3945","L-Cycloserine","b11","L3000-16","in 10mM DMSO","Transferase","Metabolism","L-Cycloserine (Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.",102.09,"339-72-0",{"v":8,"d":"8.00"},78.36,{"v":20,"d":"20.00"},195.91,"http://selleckchem.com/products/l-cycloserine.html","C3H6N2O2","free base","Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine","NC1CONC1=O",-1.788,2,2,0]
["S3951","Tannic acid","c11","L3000-16","in 10mM DMSO","CXCR","Immunology & Inflammation","Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.",{"v":1701.2,"d":"1701.20"},"1401-55-4",{"v":100,"d":"100.00"},58.78,"N/A","N/A","http://selleckchem.com/products/tannic-acid.html","C76H52O46","free base","Gallotannic acid","OC1=CC(=CC(=C1O)O)C(=O)OC2=C(O)C(=CC(=C2)C(=O)OCC3OC(OC(=O)C4=CC(=C(O)C(=C4)O)OC(=O)C5=CC(=C(O)C(=C5)O)O)C(OC(=O)C6=CC(=C(O)C(=C6)O)OC(=O)C7=CC(=C(O)C(=C7)O)O)C(OC(=O)C8=CC(=C(O)C(=C8)O)OC(=O)C9=CC(=C(O)C(=C9)O)O)C3OC(=O)C%10=CC(=C(O)C(=C%10)O)OC(=O)C%11=CC(=C(O)C(=C%11)O)O)O",8.813,21,25,31]
["S3952","3,4-Dihydroxybenzaldehyde","d11","L3000-16","in 10mM DMSO","Others","Others","3,4-Dihydroxybenzaldehyde (Protocatechuic aldehyde) is a phenolic aldehyde, a precursor in vanillin synthesis via biotransformation by cell cultures of Capsicum frutescens, a type of chili pepper.",138.12,"139-85-5",{"v":27,"d":"27.00"},195.48,"N/A","N/A","http://selleckchem.com/products/3-4-dihydroxybenzaldehyde.html","C7H6O3","free base","protocatechuic aldehyde","OC1=CC=C(C=O)C=C1O",1.105,1,2,1]
["S3956","Tetramethylpyrazine","e11","L3000-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.",136.19,"1124-11-4",{"v":27,"d":"27.00"},198.25,"N/A","N/A","http://selleckchem.com/products/tetramethylpyrazine.html","C8H12N2","free base","ligustrazine","CC1=NC(=C(C)N=C1C)C",0.659,2,0,0]
["S3957","Gamma-Oryzanol","f11","L3000-16","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.  γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).",602.89,"11042-64-1",{"v":100,"d":"100.00"},165.87,"N/A","N/A","http://selleckchem.com/products/gamma-oryzanol.html","C40H58O4","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2CCC34CC35CCC6(C)C(CCC6(C)C5CCC4C2(C)C)C(C)CCC=C(C)C",9.806,3,1,9]
["S3959","(+)-Borneol","g11","L3000-16","in 10mM DMSO","GABA Receptor","Neuronal Signaling","(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.",154.25,"464-43-7",{"v":30,"d":"30.00"},194.49,"N/A","N/A","http://selleckchem.com/products/positive-rotation-borneol.html","C10H18O","free base","N/A","CC1(C)C2CCC1(C)C(O)C2",1.975,0,1,0]
["S3960","Higenamine hydrochloride","h11","L3000-16","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.",307.77,"11041-94-4",{"v":61,"d":"61.00"},{"v":198.2,"d":"198.20"},"N/A","N/A","http://selleckchem.com/products/higenamine-hydrochloride.html","C16H17NO3.HCl","hydrochloride","Norcoclaurine HCl, (+-)-Demethylcoclaurine hydrochloride","Cl.OC1=CC=C(CC2NCCC3=CC(=C(O)C=C23)O)C=C1",3.031,0,4,2]
["S3966","Nifuratel","a2","L3000-17","in 10mM DMSO","Fungal","Microbiology","Nifuratel is a nitrofuran derivative with local antiprotozoal and antifungal activity and a broad spectrum of antibacterial action.",285.28,"4936-47-4",{"v":57,"d":"57.00"},{"v":199.8,"d":"199.80"},"<1","N/A","https://www.selleckchem.com/products/nifuratel.html","C10H11N3O5S","free base","N/A","CSCC1CN(\\N=C\\C2=CC=C(O2)[N+]([O-])=O)C(=O)O1",1.743,4,0,5]
["S3967","Flavone","b2","L3000-17","in 10mM DMSO","Apoptosis related","Apoptosis","Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.",222.24,"525-82-6",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/flavone.html","C15H10O2","free base","2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron","O=C1C=C(OC2=C1C=CC=C2)C3=CC=CC=C3",3.136,2,0,1]
["S3968","Histamine","c2","L3000-17","in 10mM DMSO","Histamine Receptor","Immunology & Inflammation","Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist.",111.15,"51-45-6",{"v":22,"d":"22.00"},197.93,"N/A","N/A","http://selleckchem.com/products/histamine.html","C5H9N3","free base","N/A","NCCC1=C[NH]C=N1",-0.714,1,2,2]
["S3970","Vindoline","d2","L3000-17","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly.",456.53,"2182-14-1",{"v":91,"d":"91.00"},199.33,"N/A","N/A","http://selleckchem.com/products/vindoline.html","C25H32N2O6","free base","N/A","CCC12C=CCN3CCC4(C(N(C)C5=C4C=CC(=C5)OC)C(O)(C1OC(C)=O)C(=O)OC)C23",1.935,5,0,6]
["S3974","(+)-Catechin hydrate","e2","L3000-17","in 10mM DMSO","COX","Immunology & Inflammation","(+)-Catechin hydrate is a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.  (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.",290.27,"225937-10-0",{"v":58,"d":"58.00"},199.81,"N/A","N/A","http://selleckchem.com/products/catechin-hydrate.html","C15H14O6.xH2O","hydrate","N/A","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S3975","Protocatechuic acid","f2","L3000-17","in 10mM DMSO","Apoptosis related","Apoptosis","Protocatechuic acid (PCA, 3,4-Dihydroxybenzoic acid, Protocatechuate), a dihydroxybenzoic acid, is a type of widely distributed naturally occurring phenolic acid.",154.12,"99-50-3",{"v":30,"d":"30.00"},194.65,"N/A","N/A","http://selleckchem.com/products/protocatechuic-acid.html","C7H6O4","free base","3,4-Dihydroxybenzoic acid, Protocatechuate","OC(=O)C1=CC(=C(O)C=C1)O",0.975,1,2,1]
["S3980","Pyridoxine","g2","L3000-17","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.",169.18,"65-23-6",{"v":33,"d":"33.00"},195.06,"N/A","N/A","http://selleckchem.com/products/pyridoxine.html","C8H11NO3","free base","Pyridoxol, Vitamin B6, Gravidox","CC1=NC=C(CO)C(=C1O)CO",{"v":-0.49,"d":"-0.490"},1,3,2]
["S3981","Sinapinic Acid","h2","L3000-17","in 10mM DMSO","ACE,HDAC","DNA Damage/DNA Repair","Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.",224.21,"530-59-6",{"v":44,"d":"44.00"},196.24,"<1","N/A","http://selleckchem.com/products/sinapinic-acid.html","C11H12O5","free base","Sinapic acid","COC1=C(O)C(=CC(=C1)\\C=C\\C(O)=O)OC",1.652,3,1,4]
["S3982","Batyl alcohol","a3","L3000-17","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Batyl alcohol (Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.",344.57,"544-62-7",{"v":68,"d":"68.00"},197.35,"N/A","N/A","http://selleckchem.com/products/batyl-alcohol.html","C21H44O3","free base","Batilol, Stearyl monoglyceride, 1-O-Octadecylglycerol, Batilolum","CCCCCCCCCCCCCCCCCCOCC(O)CO",6.715,1,2,20]
["S3983","Caryophyllene oxide","b3","L3000-17","in 10mM DMSO","Others","Others","Caryophyllene oxide, an oxygenated terpenoid existed in many plant essential oil, is well known as preservative in food, drugs and cosmetics with anti-inflammatory, anti-carcinogenic and skin penetration enhancing  properties.",220.35,"1139-30-6",{"v":44,"d":"44.00"},199.68,"<1","N/A","http://selleckchem.com/products/caryophyllene-oxide.html","C15H24O","free base","N/A","CC1(C)CC2C1CCC3(C)OC3CCC2=C",3.519,1,0,0]
["S3984","Nordihydroguaiaretic acid (NDGA)","c3","L3000-17","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase","Metabolism","Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.",302.36,"500-38-9",{"v":60,"d":"60.00"},198.44,"<1","N/A","http://selleckchem.com/products/nordihydroguaiaretic-acid.html","C18H22O4","free base","N/A","CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O",4.708,0,4,5]
["S3987","L-Tryptophan","d3","L3000-17","in 10mM DMSO","Others","Others","L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.",204.23,"73-22-3",{"v":11,"d":"11.00"},53.86,"N/A","N/A","http://selleckchem.com/products/l-tryptophan.html","C11H12N2O2","free base","N/A","NC(CC1=C[NH]C2=C1C=CC=C2)C(O)=O",-1.312,1,2,3]
["S3988","Theophylline-7-acetic acid","e3","L3000-17","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Theophylline-7-acetic acid (Acefylline, acetyloxytheophylline, Carboxymethyltheophylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class.",{"v":238.2,"d":"238.20"},"652-37-9",{"v":47,"d":"47.00"},197.31,"N/A","N/A","http://selleckchem.com/products/theophylline-7-acetic.html","C9H10N4O4","free base","Acefylline, acetyloxytheophylline, Carboxymethyltheophylline","CN1C(=O)N(C)C2=C([N](CC(O)=O)C=N2)C1=O",-0.619,4,0,2]
["S3996","Thioctic acid","f3","L3000-17","in 10mM DMSO","Others","Others","Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form., Thioctic acid (DL-α-Lipoic acid)是环状二硫抗氧化剂，可与其还原性二硫酚形式相互转换。",206.33,"1077-28-7",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/thioctic-acid.html","C8H14O2S2","free base","DL-α-Lipoic Acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S3998","(+)-α-Lipoic acid","g3","L3000-17","in 10mM DMSO","LTR,NF-κB","NF-κB","(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.",206.33,"1200-22-2",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/alpha-lipoic-acid.html","C8H14O2S2","free base","(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S4001","Cabozantinib malate","h3","L3000-17","in 10mM DMSO","Apoptosis related,Axl,c-Kit,c-Met,c-RET,FLT3,VEGFR","Protein Tyrosine Kinase","Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis.",635.59,"1140909-48-3",{"v":100,"d":"100.00"},157.33,"<1","N/A","http://selleckchem.com/products/cabozantinib-malate.html","C28H24FN3O5.C4H6O5","Malate","XL184","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3.OC(CC(O)=O)C(O)=O",3.331,8,3,11]
["S4003","Lithocholic acid","a4","L3000-17","in 10mM DMSO","FXR","Metabolism","Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.",376.57,"434-13-9",{"v":75,"d":"75.00"},199.17,"<1","N/A","http://selleckchem.com/products/lithocholic-acid.html","C24H40O3","free base","N/A","CC(CCC(O)=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C",5.184,1,1,4]
["S4004","Ethambutol 2HCl","b4","L3000-17","in 10mM DMSO","Bacterial","Microbiology","Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.",277.23,"1070-11-7",{"v":56,"d":"56.00"},{"v":202,"d":"202.00"},{"v":56,"d":"56.00"},{"v":202,"d":"202.00"},"http://selleckchem.com/products/ethambutol-hcl.html","C10H24N2O2.2HCl","Dihydrochloride","CL40881","Cl.Cl.CCC(CO)NCCNC(CC)CO",0.874,0,4,9]
["S4007","Pentamidine isethionate","c4","L3000-17","in 10mM DMSO","phosphatase","Metabolism","Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.",592.68,"140-64-7",{"v":100,"d":"100.00"},168.73,{"v":100,"d":"100.00"},168.73,"http://selleckchem.com/products/pentamidine-isethionate.html","C19H24N4O2.2C2H6O4S","isethionate","N/A","NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1.OCC[S](O)(=O)=O.OCC[S](O)(=O)=O",0.751,2,4,14]
["S4009","Mirabegron","d4","L3000-17","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.",396.51,"223673-61-8",{"v":79,"d":"79.00"},199.24,"<1","N/A","http://selleckchem.com/products/mirabegron-ym178.html","C21H24N4O2S","free base","YM 178","NC1=NC(=CS1)CC(=O)NC2=CC=C(CCNCC(O)C3=CC=CC=C3)C=C2",{"v":2.26,"d":"2.260"},2,4,9]
["S4010","Acebutolol HCl","e4","L3000-17","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.",372.89,"34381-68-5",{"v":75,"d":"75.00"},201.13,{"v":75,"d":"75.00"},201.13,"http://selleckchem.com/products/acebutolol-hcl.html","C18H28N2O4.HCl","Hydrochloride","N/A","Cl.CCCC(=O)NC1=CC(=C(OCC(O)CNC(C)C)C=C1)C(C)=O",1.997,3,3,10]
["S4011","Ampiroxicam","f4","L3000-17","in 10mM DMSO","COX","Neuronal Signaling","Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.",447.46,"99464-64-9",{"v":90,"d":"90.00"},201.14,"<1","N/A","http://selleckchem.com/products/ampiroxicam.html","C20H21N3O7S","free base","CP 65703","CCOC(=O)OC(C)OC1=C(N(C)[S](=O)(=O)C2=C1C=CC=C2)C(=O)NC3=NC=CC=C3",1.718,8,1,8]
["S4012","Desloratadine","g4","L3000-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Desloratadine (SCH-34117, NSC 675447) is a potent antagonist for  human histamine H1 receptor with IC50 of 51 nM.",310.82,"100643-71-8",{"v":26,"d":"26.00"},83.65,"<1","N/A","http://selleckchem.com/products/desloratadine.html","C19H19ClN2","free base","SCH-34117, NSC 675447","ClC1=CC2=C(C=C1)C(=C3CCNCC3)C4=C(CC2)C=CC=N4",4.213,1,1,0]
["S4014","Hyoscyamine","h4","L3000-17","in 10mM DMSO","AChR","Neuronal Signaling","Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.",289.37,"101-31-5",{"v":58,"d":"58.00"},200.44,"<1","N/A","http://selleckchem.com/products/hyoscyamine-daturine.html","C17H23NO3","free base","Daturine","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",1.721,2,1,5]
["S4017","Allylthiourea","a5","L3000-17","in 10mM DMSO","ROS","Immunology & Inflammation","Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.",116.18,"109-57-9",{"v":23,"d":"23.00"},197.97,"<1","N/A","http://selleckchem.com/products/allylthiourea.html","C4H8N2S","free base","N/A","NC(=S)NCC=C",0.842,0,2,3]
["S4018","Sennoside B","b5","L3000-17","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation., Sennoside B，一种从大黄根茎中分离得到的刺激性泻药，抑制PDGF刺激的细胞增殖。",862.74,"128-57-4",{"v":100,"d":"100.00"},115.91,"<1","N/A","http://selleckchem.com/products/sennoside-b.html","C42H38O20","Free Base","N/A","OCC1OC(OC2=CC=CC3=C2C(=O)C4=C(O)C=C(C=C4C3C5C6=C(C(=O)C7=C(O)C=C(C=C57)C(O)=O)C(=CC=C6)OC8OC(CO)C(O)C(O)C8O)C(O)=O)C(O)C(O)C1O",0.409,8,10,9]
["S4019","Avanafil","c5","L3000-17","in 10mM DMSO","PDE","Metabolism","Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.",483.95,"330784-47-9",{"v":97,"d":"97.00"},200.43,"<1","N/A","http://selleckchem.com/products/avanafil.html","C23H26ClN7O3","free base","N/A","COC1=C(Cl)C=C(CNC2=C(C=NC(=N2)N3CCCC3CO)C(=O)NCC4=NC=CC=N4)C=C1",2.165,6,3,9]
["S4022","Probenecid","d5","L3000-17","in 10mM DMSO","Taste Receptor,TRP Channel","Transmembrane Transporters","Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.",285.36,"57-66-9",{"v":57,"d":"57.00"},199.75,"<1","N/A","http://selleckchem.com/products/probenecid-benemid.html","C13H19NO4S","free base","Benemid","CCCN(CCC)[S](=O)(=O)C1=CC=C(C=C1)C(O)=O",2.321,3,0,7]
["S4023","Procaine HCl","e5","L3000-17","in 10mM DMSO","AChR,NMDAR,Sodium Channel","Transmembrane Transporters","Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.",272.77,"51-05-8",{"v":55,"d":"55.00"},201.64,{"v":55,"d":"55.00"},201.64,"http://selleckchem.com/products/procaine-novocaine-hcl.html","C13H20N2O2.HCl","HCl","Novocaine HCl","Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1",2.157,2,1,7]
["S4024","Homatropine Methylbromide","f5","L3000-17","in 10mM DMSO","AChR","Neuronal Signaling","Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.",370.28,"80-49-9",{"v":74,"d":"74.00"},199.85,{"v":74,"d":"74.00"},199.85,"http://selleckchem.com/products/homatropine-methylbromide.html","C17H24NO3.Br","quaternary-N bromide salt","N/A","[Br-].C[N+]1(C)C2CCC1CC(C2)OC(=O)C(O)C3=CC=CC=C3",-2.076,2,1,4]
["S4025","Homatropine Bromide","g5","L3000-17","in 10mM DMSO","AChR","Neuronal Signaling","Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.",356.25,"51-56-9",{"v":71,"d":"71.00"},{"v":199.3,"d":"199.30"},{"v":71,"d":"71.00"},{"v":199.3,"d":"199.30"},"http://selleckchem.com/products/homatropine-bromide.html","C16H21NO3.HBr","quaternary-N bromide salt","N/A","Br.CN1C2CCC1CC(C2)OC(=O)C(O)C3=CC=CC=C3",2.188,2,1,4]
["S4026","Hydroxyzine 2HCl","h5","L3000-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.",447.83,"2192-20-3",{"v":90,"d":"90.00"},200.97,{"v":90,"d":"90.00"},200.97,"http://selleckchem.com/products/hydroxyzine-2hcl.html","C21H27ClN2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",4.231,1,1,8]
["S4034","Diphemanil Methylsulfate","a6","L3000-17","in 10mM DMSO","AChR","Neuronal Signaling","Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).",389.51,"62-97-5",{"v":25,"d":"25.00"},64.18,{"v":28,"d":"28.00"},71.89,"http://selleckchem.com/products/diphemanil-methylsulfate.html","C20H24N.CH3O4S","Methylsulfate","N/A","CO[S]([O-])(=O)=O.C[N+]1(C)CC[C](CC1)=[C](C2=CC=CC=C2)C3=CC=CC=C3",0.038,1,0,3]
["S4037","Doxapram HCl","b6","L3000-17","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.",432.98,"7081-53-0",{"v":87,"d":"87.00"},200.93,{"v":25,"d":"25.00"},57.74,"http://selleckchem.com/products/doxapram-hcl.html","C24H30N2O2.HCl.H2O","HCl","N/A","O.Cl.CCN1CC(CCN2CCOCC2)C(C1=O)(C3=CC=CC=C3)C4=CC=CC=C4",3.218,2,0,6]
["S4039","Methazolamide","c6","L3000-17","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.",236.27,"554-57-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/methazolamide.html","C5H8N4O3S2","free base","CL 8490","CN1N=C(SC1=NC(C)=O)[S](N)(=O)=O",{"v":0.03,"d":"0.030"},5,1,1]
["S4040","Norethindrone","d6","L3000-17","in 10mM DMSO","Others,0","Others","Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.",298.42,"68-22-4",{"v":60,"d":"60.00"},201.06,"<1","N/A","http://selleckchem.com/products/norethindrone-norethisterone.html","C20H26O2","free base","Norethisterone","CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.315,1,0,0]
["S4041","Olsalazine Sodium","e6","L3000-17","in 10mM DMSO","Anti-infection","Microbiology","Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.",{"v":346.2,"d":"346.20"},"6054-98-4",{"v":4,"d":"4.00"},11.55,{"v":41,"d":"41.00"},118.43,"http://selleckchem.com/products/olsalazine-sodium.html","C14H8N2O6.2Na","Disodium Salt","N/A","[Na+].[Na+].OC1=CC=C(C=C1C([O-])=O)N=NC2=CC=C(O)C(=C2)C([O-])=O",0.026,2,2,4]
["S4042","Nafcillin Sodium","f6","L3000-17","in 10mM DMSO","β-lactamase","Microbiology","Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.",454.47,"7177-50-6",{"v":91,"d":"91.00"},200.23,{"v":91,"d":"91.00"},200.23,"http://selleckchem.com/products/nafcillin-sodium.html","C21H21N2O5S.H2O.Na","sodium Salt","CL 8491","O.CCOC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C(=O)O[Na])C4=C(C=CC=C4)C=C1",2.213,5,1,6]
["S4045","Pheniramine Maleate","g6","L3000-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.",356.42,"132-20-7",{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},"http://selleckchem.com/products/pheniramine-maleate.html","C16H20N2.C4H4O4","Maleate","N/A","CN(C)CCC(C1=CC=CC=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",0.036,3,0,7]
["S4046","Estradiol Cypionate","h6","L3000-17","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.",396.56,"313-06-4",{"v":79,"d":"79.00"},199.21,"<1","N/A","http://selleckchem.com/products/estradiol-cypionate.html","C26H36O3","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2OC(=O)CCC5CCCC5",6.589,2,1,5]
["S4047","Bisacodyl","a7","L3000-17","in 10mM DMSO","Others","Others","Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.",361.39,"603-50-9",{"v":72,"d":"72.00"},199.23,"<1","N/A","http://selleckchem.com/products/bisacodyl.html","C22H19NO4","free base","N/A","CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(OC(C)=O)C=C2)C3=CC=CC=N3",3.691,5,0,7]
["S4049","Valdecoxib","b7","L3000-17","in 10mM DMSO","COX","Neuronal Signaling","Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.",314.36,"181695-72-7",{"v":63,"d":"63.00"},200.41,"<1","N/A","http://selleckchem.com/products/valdecoxib.html","C16H14N2O3S","free base","N/A","CC1=C(C2=CC=C(C=C2)[S](N)(=O)=O)C(=NO1)C3=CC=CC=C3",{"v":2.6,"d":"2.600"},4,1,3]
["S4051","Nabumetone","c7","L3000-17","in 10mM DMSO","COX","Neuronal Signaling","Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.",228.29,"42924-53-8",{"v":46,"d":"46.00"},{"v":201.5,"d":"201.50"},"<1","N/A","http://selleckchem.com/products/nabumetone.html","C15H16O2","free base","BRL-14777","COC1=CC=C2C=C(CCC(C)=O)C=CC2=C1",2.943,2,0,4]
["S4053","Sertraline HCl","d7","L3000-17","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.",342.69,"79559-97-0",{"v":69,"d":"69.00"},201.35,"<1","N/A","http://selleckchem.com/products/sertraline-hcl.html","C17H17Cl2N.HCl","HCl","CP-51974-1 HCl","Cl.CNC1CCC(C2=CC=C(Cl)C(=C2)Cl)C3=C1C=CC=C3",5.378,0,1,2]
["S4054","Spironolactone","e7","L3000-17","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.",416.57,"52-01-7",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/spironolactone.html","C24H32O4S","free base","N/A","CC(=O)SC1CC2=CC(=O)CCC2(C)C3CCC4(C)C(CCC45CCC(=O)O5)C13",3.731,4,0,2]
["S4059","Sodium Nitroprusside Dihydrate","f7","L3000-17","in 10mM DMSO","Others","Others","Sodium Nitroprusside  Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.",297.95,"13755-38-9",{"v":60,"d":"60.00"},201.38,{"v":60,"d":"60.00"},201.38,"http://selleckchem.com/products/sodium-nitroprusside-dihydrate.html","C5H4FeN6Na2O3","Dihydrate","N/A","[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N",0.571,1,0,1]
["S4065","Guanabenz Acetate","g7","L3000-17","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Guanabenz Acetate (WY-8678) is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.",291.13,"23256-50-0",{"v":58,"d":"58.00"},199.22,"<1","N/A","http://selleckchem.com/products/guanabenz-wy-8678-acetate.html","C8H8Cl2N4.C2H4O2","Acetate","WY-8678 Acetate","CC(O)=O.NC(=N)N/N=C/C1=C(Cl)C=CC=C1Cl",1.987,2,2,3]
["S4070","Guanidine HCl","h7","L3000-17","in 10mM DMSO","Others","Others","Guanidine HCl (Aminoformamidine), the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.",95.53,"50-01-1",{"v":19,"d":"19.00"},198.89,{"v":19,"d":"19.00"},198.89,"http://selleckchem.com/products/guanidine-aminoformamidine-hcl.html","CH5N3.HCl","Hydrochloride","Aminoformamidine HCl","Cl.NC(N)=N",-0.606,0,2,0]
["S4071","Griseofulvin","a8","L3000-17","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.",352.77,"126-07-8",{"v":50,"d":"50.00"},141.74,"<1","N/A","http://selleckchem.com/products/griseofulvin.html","C17H17ClO6","free base","N/A","COC1=CC(=C2C(=O)C3(OC2=C1Cl)C(C)CC(=O)C=C3OC)OC",2.495,6,0,3]
["S4072","Decamethonium Bromide","b8","L3000-17","in 10mM DMSO","AChR","Neuronal Signaling","Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.",418.29,"541-22-0",{"v":34,"d":"34.00"},81.28,{"v":84,"d":"84.00"},200.82,"http://selleckchem.com/products/decamethonium-bromide.html","C16H38N2.2Br","Bromide","N/A","[Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C",-3.707,0,0,11]
["S4073","Sodium 4-Aminosalicylate","c8","L3000-17","in 10mM DMSO","NF-κB","NF-κB","Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.",211.15,"6018-19-5",{"v":42,"d":"42.00"},198.91,{"v":42,"d":"42.00"},198.91,"http://selleckchem.com/products/aminosalicylate-sodium.html","C7H7NO3.2H2O.Na","Sodium Salt","N/A","[Na+].NC1=CC(=C(C=C1)C([O-])=O)O",-1.003,0,2,1]
["S4075","Zinc Pyrithione","d8","L3000-17","in 10mM DMSO","Fungal,Proton Pump","Transmembrane Transporters","Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.",{"v":317.7,"d":"317.70"},"13463-41-7",{"v":30,"d":"30.00"},94.43,"<1","N/A","http://selleckchem.com/products/zinc-pyrithione.html","C10H8N2O2S2Zn","free base","OM-1563","O1N2C=CC=CC2=[SH][Zn]13ON4C=CC=CC4=[SH]3",0.874,2,0,0]
["S4076","Propranolol HCl","e8","L3000-17","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.",{"v":295.8,"d":"295.80"},"318-98-9",{"v":59,"d":"59.00"},199.46,{"v":6,"d":"6.00"},20.28,"http://selleckchem.com/products/propranolol-hcl.html","C16H21NO2.HCl","Hydrochloride","AY-64043, ICI-45520, NCS-91523","Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12",2.922,1,2,6]
["S4078","Mefenamic Acid","f8","L3000-17","in 10mM DMSO","COX","Neuronal Signaling","Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.",241.29,"61-68-7",{"v":48,"d":"48.00"},198.93,"<1","N/A","http://selleckchem.com/products/mefenamic-acid.html","C15H15NO2","free base","CI 473, CN-35355","CC1=C(C)C(=CC=C1)NC2=CC=CC=C2C(O)=O",3.982,1,1,3]
["S4079","Ticagrelor","g8","L3000-17","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Ticagrelor (AZD 6140, AR-C 126532XX) is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.",522.57,"274693-27-5",{"v":100,"d":"100.00"},191.36,"<1","N/A","http://selleckchem.com/products/ticagrelor.html","C23H28F2N6O4S","free base","AZD 6140, AR-C 126532XX","CCCSC1=NC2=C(N=N[N]2C3CC(OCCO)C(O)C3O)C(=N1)NC4CC4C5=CC(=C(F)C=C5)F",2.843,5,4,10]
["S4080","Triamterene","h8","L3000-17","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.",253.26,"396-01-0",{"v":20,"d":"20.00"},78.97,"<1","N/A","http://selleckchem.com/products/triamterene.html","C12H11N7","free base","SKF8542","NC1=NC2=C(N=C(C3=CC=CC=C3)C(=N2)N)C(=N1)N",1.017,4,3,1]
["S4081","Sulfacetamide Sodium","a9","L3000-17","in 10mM DMSO","Anti-infection,Autophagy","Immunology & Inflammation","Sulfacetamide Sodium is an anti-biotic.",236.22,"127-56-0",{"v":19,"d":"19.00"},80.43,{"v":51,"d":"51.00"},{"v":215.9,"d":"215.90"},"http://selleckchem.com/products/sulfacetamide-sodium.html","C8H10N2O3S.Na","Sodium Salt","N/A","[Na+].CC(=O)[N-][S](=O)(=O)C1=CC=C(N)C=C1",-0.118,3,1,2]
["S4082","Spiramycin","b9","L3000-17","in 10mM DMSO","Antibiotics","Microbiology","Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).",843.05,"8025-81-8",{"v":100,"d":"100.00"},118.62,"<1","N/A","http://selleckchem.com/products/spiramycin.html","C43H74N2O14","free base","Formacidine","COC1C(O)CC(=O)OC(C)C/C=C/C=C/C(OC2CCC(C(C)O2)N(C)C)C(C)CC(CC=O)C1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C",2.049,10,3,11]
["S4083","Vitamin A Acetate","c9","L3000-17","in 10mM DMSO","Vitamin","Metabolism","Vitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important.",328.49,"127-47-9",{"v":65,"d":"65.00"},197.88,"<1","N/A","http://selleckchem.com/products/vitamin-a-acetate.html","C22H32O2","free base","Retinyl (Retinol) Acetate","CC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C",5.695,2,0,7]
["S4086","Loxapine Succinate","d9","L3000-17","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Loxapine Succinate(NSC 759578) is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.",{"v":445.9,"d":"445.90"},"27833-64-3",{"v":89,"d":"89.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/loxapine-succinate.html","C18H18ClN3O.C4H6O4","Succinate","NSC 759578","CN1CCN(CC1)C2=NC3=C(OC4=C2C=C(Cl)C=C4)C=CC=C3.OC(=O)CCC(O)=O",0.039,4,0,4]
["S4088","Flumethasone","e9","L3000-17","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.",410.45,"2135-17-3",{"v":82,"d":"82.00"},199.78,"<1","N/A","http://selleckchem.com/products/flumethasone.html","C22H28F2O5","free base","RS-2177, NSC-54702,Flumetasone","CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.546,2,2,2]
["S4089","Halobetasol Propionate","f9","L3000-17","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.",484.96,"66852-54-8",{"v":97,"d":"97.00"},200.02,"<1","N/A","http://selleckchem.com/products/halobetasol-propionate.html","C25H31ClF2O5","free base","BMY-30056, CGP-14458,Ulobetasol propionate","CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.797,4,1,5]
["S4090","Fenspiride HCl","g9","L3000-17","in 10mM DMSO","PDE","Metabolism","Fenspiride(Decaspiride) is a bronchodilator with anti-inflammatory properties, inhibiting phosphodiesterase 4 and phosphodiesterase 3 activities with logIC50 values of 4.16 and 3.44, respectively, in human isolated bronchi.",296.79,"5053-08-7",{"v":9,"d":"9.00"},30.32,{"v":59,"d":"59.00"},198.79,"http://selleckchem.com/products/Fenspiride-hcl.html","C15H20N2O2.HCl","Hydrochloride","Decaspiride","Cl.O=C1NCC2(CCN(CCC3=CC=CC=C3)CC2)O1",2.089,2,1,3]
["S4095","Difluprednate","h9","L3000-17","in 10mM DMSO","Others","Others","Difluprednate (difluoroprednisolone butyrate acetate, DFBA, CM 9155) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications.",508.55,"23674-86-4",{"v":100,"d":"100.00"},196.64,"<1","N/A","http://selleckchem.com/products/difluprednate.html","C27H34F2O7","free base","CM 9155","CCCC(=O)OC1(CCC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)COC(C)=O",3.108,6,1,8]
["S4098","Halcinonide","a10","L3000-17","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.",454.96,"3093-35-4",{"v":90,"d":"90.00"},197.82,"<1","N/A","http://selleckchem.com/products/halcinonide.html","C24H32ClFO5","free base","SQ-18566","CC1(C)OC2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CCl",2.384,4,1,2]
["S4101","Voglibose","b10","L3000-17","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.",267.28,"83480-29-9",{"v":74,"d":"74.00"},276.86,{"v":74,"d":"74.00"},276.86,"http://selleckchem.com/products/voglibose.html","C10H21NO7","free base","AO 128","OCC(CO)NC1CC(O)(CO)C(O)C(O)C1O",-4.083,0,7,5]
["S4102","Eprosartan Mesylate","c10","L3000-17","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Eprosartan(SKF-108566J) is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.",520.62,"144143-96-4",{"v":104,"d":"104.00"},199.76,"<1","N/A","http://selleckchem.com/products/eprosartan-mesylate.html","C23H24N2O4S.CH4O3S","Mesylate","SKF-108566J","CCCCC1=NC=C(\\C=C(CC2=CC=CS2)\\C(O)=O)[N]1CC3=CC=C(C=C3)C(O)=O.C[S](O)(=O)=O",4.418,3,0,10]
["S4104","Diminazene Aceturate","d10","L3000-17","in 10mM DMSO","ACE,Parasite","Microbiology","Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.  The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.",515.52,"908-54-3",{"v":19,"d":"19.00"},36.86,{"v":100,"d":"100.00"},193.98,"http://selleckchem.com/products/diminazene-aceturate.html","C14H15N7.2C4H7NO3","Aceturate","Diminazene diaceturate","CC(=O)NCC(O)=O.CC(=O)NCC(O)=O.NC(=N)C1=CC=C(NN=NC2=CC=C(C=C2)C(N)=N)C=C1",-0.592,6,5,9]
["S4107","Clofazimine","e10","L3000-17","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dyes,Phospholipase (e.g. PLA)","Metabolism","Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.",{"v":473.4,"d":"473.40"},"2030-63-9",{"v":5,"d":"5.00"},10.56,"<1","N/A","http://selleckchem.com/products/clofazimine.html","C27H22Cl2N4","free base","NSC-141046","CC(C)N=C1C=C2N(C3=CC=C(Cl)C=C3)C4=C(C=CC=C4)N=C2C=C1NC5=CC=C(Cl)C=C5",7.137,2,1,4]
["S4110","Estradiol Benzoate","f10","L3000-17","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol benzoate(β-Estradiol 3-benzoate) is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.",376.49,"50-50-0",{"v":75,"d":"75.00"},199.21,"<1","N/A","http://selleckchem.com/products/estradiol-benzoate.html","C25H28O3","free base","β-Estradiol 3-benzoate","CC12CCC3C(CCC4=CC(=CC=C34)OC(=O)C5=CC=CC=C5)C1CCC2O",5.512,2,1,3]
["S4113","Desvenlafaxine","g10","L3000-17","in 10mM DMSO","Adrenergic Receptor,Serotonin Transporter","Neuronal Signaling","Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.",263.38,"93413-62-8",{"v":37,"d":"37.00"},140.48,"<1","N/A","http://selleckchem.com/products/desvenlafaxine.html","C16H25NO2","Free Base","WY 45233  Succinate","CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2",2.796,0,1,4]
["S4114","Triclabendazole","h10","L3000-17","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.",359.66,"68786-66-3",{"v":72,"d":"72.00"},200.19,"<1","N/A","http://selleckchem.com/products/triclabendazole.html","C14H9Cl3N2OS","free base","CGA-89317,tcbz","CSC1=NC2=C([NH]1)C=C(Cl)C(=C2)OC3=C(Cl)C(=CC=C3)Cl",5.982,2,1,3]
["S4116","Isovaleramide","a11","L3000-17","in 10mM DMSO","Dehydrogenase","Metabolism","Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.",101.15,"541-46-8",{"v":20,"d":"20.00"},197.73,"<1","N/A","http://selleckchem.com/products/isovaleramide.html","C5H11NO","free base","3-Methylbutanamide","CC(C)CC(N)=O",0.542,1,1,2]
["S4118","Histamine 2HCl","b11","L3000-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Histamine(Ceplene) is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.",184.07,"56-92-8",{"v":3,"d":"3.00"},{"v":16.3,"d":"16.30"},{"v":37,"d":"37.00"},201.01,"http://selleckchem.com/products/histamine-2hcl.html","C5H9N3.2HCl","Dihydrochloride","Ceplene","Cl.Cl.NCCC1=C[NH]C=N1",{"v":0.05,"d":"0.050"},1,2,2]
["S4119","Pefloxacin Mesylate Dihydrate","c11","L3000-17","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Pefloxacin Mesylate Dihydrate (1589 RB,Pefloxacinium mesylate dihydrate) is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.",465.49,"149676-40-4",{"v":9,"d":"9.00"},19.33,{"v":67,"d":"67.00"},143.93,"http://selleckchem.com/products/pefloxacin-mesylate-dihydrate.html","C17H20FN3O3.CH4O3S.2H2O","Mesylate","1589 RB,Pefloxacinium mesylate dihydrate","O.O.CCN1C=C(C(O)=O)C(=O)C2=C1C=C(N3CCN(C)CC3)C(=C2)F.C[S](O)(=O)=O",-2.033,2,0,3]
["S4120","Sulconazole Nitrate","d11","L3000-17","in 10mM DMSO","Fungal","Microbiology","Sulconazole Nitrate(Exelderm,RS 44872) is an imidazole derivative with broad-spectrum antifungal activity.",460.76,"61318-91-0",{"v":92,"d":"92.00"},199.67,"<1","N/A","http://selleckchem.com/products/sulconazole-nitrate.html","C18H15Cl3N2S.HNO3","Nitrate","Exelderm,RS 44872","O[N+]([O-])=O.ClC1=CC=C(CSC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C=C1",4.467,1,0,6]
["S4123","Timolol Maleate","e11","L3000-17","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Timolol Maleate (MK-950,(S)-Timolol Maleate) is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.",432.49,"26921-17-5",{"v":86,"d":"86.00"},198.85,"<1","N/A","http://selleckchem.com/products/timolol-maleate.html","C13H24N4O3S.C4H4O4","Maleate","MK-950,(S)-Timolol Maleate","CC(C)(C)NCC(O)COC1=NSN=C1N2CCOCC2.OC(=O)\\C=C/C(O)=O",-1.539,6,2,9]
["S4124","Tolazoline HCl","f11","L3000-17","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tolazoline(Imidaline hydrochloride,NSC35110 hydrochloride) is a non-selective competitive α-adrenergic receptor antagonist.",196.68,"59-97-2",{"v":39,"d":"39.00"},198.29,{"v":39,"d":"39.00"},198.29,"http://selleckchem.com/products/tolazoline-hcl.html","C10H12N2.HCl","Hydrochloride","Imidaline hydrochloride,NSC35110 hydrochloride","Cl.C1CN=C(CC2=CC=CC=C2)N1",1.533,1,1,2]
["S4125","Sodium Phenylbutyrate","g11","L3000-17","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.",187.19,"1716-12-7",{"v":8,"d":"8.00"},42.97,{"v":30,"d":"30.00"},161.13,"http://selleckchem.com/products/sodium-phenylbutyrate.html","C10H11O2.Na","Sodium Salt","4-PBA, 4-Phenylbutyric acid, NaPB","[Na]OC(=O)CCCC1=CC=CC=C1",2.497,2,0,5]
["S4131","Levodropropizine","h11","L3000-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levodropropizine((S)-(-)-Dropropizine,DF-526) possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.",236.31,"99291-25-5",{"v":47,"d":"47.00"},198.89,{"v":15,"d":"15.00"},63.48,"http://selleckchem.com/products/levodropropizine.html","C13H20N2O2","free base","(S)-(-)-Dropropizine,DF-526","OCC(O)CN1CCN(CC1)C2=CC=CC=C2",0.899,0,2,4]
["S4135","Clorprenaline HCl","a2","L3000-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect.",250.16,"6933-90-0",{"v":50,"d":"50.00"},199.87,{"v":50,"d":"50.00"},199.87,"http://selleckchem.com/products/clorprenaline-hcl.html","C11H16ClNO.HCl","Hydrochloride","NSC 334693","Cl.CC(C)NCC(O)C1=CC=CC=C1Cl",2.629,0,2,4]
["S4136","Carprofen","b2","L3000-18","in 10mM DMSO","COX","Neuronal Signaling","Carprofen inhibits canine COX2 with IC50 of 30 nM.",273.71,"53716-49-7",{"v":55,"d":"55.00"},200.94,"<1","N/A","http://selleckchem.com/products/carprofen.html","C15H12ClNO2","free base","N/A","CC(C(O)=O)C1=CC2=C(C=C1)C3=C([NH]2)C=CC(=C3)Cl",4.114,1,1,2]
["S4147","Azithromycin Dihydrate","c2","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Azithromycin Dihydrate(CP-62993 dihydrate) is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.",785.02,"117772-70-0",{"v":100,"d":"100.00"},127.39,{"v":10,"d":"10.00"},12.74,"http://selleckchem.com/products/azithromycin-dihydrate.html","C38H72N2O12.2H2O","free base","CP-62993 dihydrate","O.O.CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",1.663,7,3,7]
["S4149","Amfenac Sodium Monohydrate","d2","L3000-18","in 10mM DMSO","COX","Neuronal Signaling","Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.",295.27,"61618-27-7",{"v":59,"d":"59.00"},199.82,{"v":59,"d":"59.00"},199.82,"http://selleckchem.com/products/amfenac-sodium-monohydrate.html","C15H12NO3.H2O.Na","free base","N/A","O.[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=CC=C2",{"v":0.47,"d":"0.470"},1,1,4]
["S4151","Penfluridol","e2","L3000-18","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.",523.97,"26864-56-2",{"v":100,"d":"100.00"},190.85,"<1","N/A","http://selleckchem.com/products/penfluridol.html","C28H27ClF5NO","free base","TLP-607,R-16341","OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(=C(Cl)C=C4)C(F)(F)F",7.311,0,0,8]
["S4152","Ethamsylate","f2","L3000-18","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.",263.31,"2624-44-4",{"v":53,"d":"53.00"},201.28,{"v":53,"d":"53.00"},201.28,"http://selleckchem.com/products/ethamsylate.html","C6H6O5S.C4H11N","Diethylamine","Etamsylate","CCNCC.OC1=CC=C(O)C(=C1)[S](O)(=O)=O",{"v":1.16,"d":"1.160"},0,3,3]
["S4155","Chlorzoxazone","g2","L3000-18","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.",169.57,"95-25-0",{"v":34,"d":"34.00"},200.51,"<1","N/A","http://selleckchem.com/products/chlorzoxazone.html","C7H4ClNO2","free base","Chlorzoxazon,Paraflex","ClC1=CC2=C(OC(=O)N2)C=C1",2.004,2,1,0]
["S4159","Bezafibrate","h2","L3000-18","in 10mM DMSO","PPAR","Metabolism","Bezafibrate (BM 15075) is the first clinically tested dual and pan-PPAR co-agonism.",361.82,"41859-67-0",{"v":72,"d":"72.00"},198.99,"<1","N/A","http://selleckchem.com/products/bezafibrate.html","C19H20ClNO4","free base","BM 15075","CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O",3.868,3,1,7]
["S4160","Penicillin G Sodium","a3","L3000-18","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture","Microbiology","Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp.",356.37,"69-57-8",{"v":71,"d":"71.00"},199.23,{"v":71,"d":"71.00"},199.23,"http://selleckchem.com/products/benzylpenicillin-sodium.html","C16H18N2O4S.Na","Sodium Salt","Benzylpenicillin Sodium","[Na+].CC1(C)SC2C(NC(=O)CC3=CC=CC=C3)C(=O)N2C1C([O-])=O",{"v":-0.35,"d":"-0.350"},2,1,4]
["S4162","Benzethonium Chloride","b3","L3000-18","in 10mM DMSO","AChR","Neuronal Signaling","Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.",448.08,"121-54-0",{"v":90,"d":"90.00"},200.86,{"v":90,"d":"90.00"},200.86,"http://selleckchem.com/products/benzethonium-chloride.html","C27H42NO2.Cl","Chloride","N/A","[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1",2.147,2,0,12]
["S4164","Doxofylline","c3","L3000-18","in 10mM DMSO","PDE","Metabolism","Doxofylline (Doxophylline) is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.",266.25,"69975-86-6",{"v":53,"d":"53.00"},199.06,{"v":24,"d":"24.00"},90.14,"http://selleckchem.com/products/doxofylline.html","C11H14N4O4","free base","Doxophylline","CN1C(=O)N(C)C2=C([N](CC3OCCO3)C=N2)C1=O",-0.344,5,0,2]
["S4165","Benzydamine HCl","d3","L3000-18","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.",345.87,"132-69-4",{"v":69,"d":"69.00"},{"v":199.5,"d":"199.50"},{"v":69,"d":"69.00"},{"v":199.5,"d":"199.50"},"http://selleckchem.com/products/benzydamine-hcl.html","C19H23N3O.HCl","Hydrochloride","AF864","Cl.CN(C)CCCOC1=N[N](CC2=CC=CC=C2)C3=CC=CC=C13",4.368,2,0,7]
["S4166","Chlorpropamide","e3","L3000-18","in 10mM DMSO","ATPase","Transmembrane Transporters","Chlorpropamide inhibits Na(+),K(+)-ATPase and stimulates a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane. Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.",276.74,"94-20-2",{"v":55,"d":"55.00"},198.74,"<1","N/A","http://selleckchem.com/products/chlorpropamide.html","C10H13ClN2O3S","free base","N/A","CCCNC(=O)N[S](=O)(=O)C1=CC=C(Cl)C=C1",2.058,3,2,4]
["S4167","Cyromazine","f3","L3000-18","in 10mM DMSO","Parasite","Microbiology","Cyromazine(Cyromazin,CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide.",166.18,"66215-27-8",{"v":33,"d":"33.00"},198.58,{"v":1,"d":"1.00"},6.02,"http://selleckchem.com/products/cyromazine.html","C6H10N6","free base","Cyromazin,CGA-72662","NC1=NC(=NC(=N1)N)NC2CC2",0.313,3,3,2]
["S4169","Teriflunomide","g3","L3000-18","in 10mM DMSO","Dehydrogenase,Immunology & Inflammation related","Metabolism","Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.",270.21,"163451-81-8",{"v":32,"d":"32.00"},118.43,"<1","N/A","http://selleckchem.com/products/teriflunomide.html","C12H9F3N2O2","free base","A77 1726, HMR-1726","C/C(O)=C(C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F",2.091,1,2,3]
["S4170","Coumarin","h3","L3000-18","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.",146.14,"91-64-5",{"v":29,"d":"29.00"},198.44,"<1","N/A","http://selleckchem.com/products/coumarin.html","C9H6O2","free base","N/A","O=C1OC2=C(C=CC=C2)C=C1",1.899,2,0,0]
["S4171","Choline Chloride","a4","L3000-18","in 10mM DMSO","AChR","Neuronal Signaling","Choline chloride(Hepacholine) is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.",139.62,"67-48-1",{"v":28,"d":"28.00"},200.54,{"v":28,"d":"28.00"},200.54,"http://selleckchem.com/products/choline-chloride.html","C5H14NO.Cl","Chloride","Hepacholine","[Cl-].C[N+](C)(C)CCO",-4.248,0,1,2]
["S4172","Cetylpyridinium Chloride","b4","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Cetylpyridinium chloride(CPC) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.",339.99,"123-03-5",{"v":68,"d":"68.00"},200.01,{"v":68,"d":"68.00"},200.01,"http://selleckchem.com/products/cetylpyridinium-chloride.html","C21H38N.Cl","Chloride","CPC","[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1",5.563,0,0,15]
["S4175","Sulfaguanidine","c4","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Sulfaguanidine is a sulfonamide used as an anti-infective agent.",214.24,"57-67-0",{"v":43,"d":"43.00"},200.71,"<1","N/A","http://selleckchem.com/products/sulfaguanidine.html","C7H10N4O2S","free base","N/A","NC(=N)N[S](=O)(=O)C1=CC=C(N)C=C1",-0.377,2,3,3]
["S4177","Uracil","d4","L3000-18","in 10mM DMSO","Others","Others","Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical.",112.09,"66-22-8",{"v":22,"d":"22.00"},196.27,"<1","N/A","http://selleckchem.com/products/uracil.html","C4H4N2O2","free base","N/A","O=C1NC=CC(=O)N1",-1.012,2,2,0]
["S4181","Nicardipine HCl","e4","L3000-18","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.",515.99,"54527-84-3",{"v":100,"d":"100.00"},{"v":193.8,"d":"193.80"},"<1","N/A","http://selleckchem.com/products/nicardipine-hcl.html","C26H29N3O6.HCl","Hydrochloride","RS-69216,YC-93","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",{"v":3.87,"d":"3.870"},4,1,11]
["S4182","Nifuroxazide","f4","L3000-18","in 10mM DMSO","STAT","JAK/STAT","Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.",275.22,"965-52-6",{"v":55,"d":"55.00"},199.84,"<1","N/A","http://selleckchem.com/products/nifuroxazide.html","C12H9N3O5","free base","N/A","OC1=CC=C(C=C1)C(=O)N/N=C/C2=CC=C(O2)[N+]([O-])=O",1.855,3,2,4]
["S4184","Penciclovir","g4","L3000-18","in 10mM DMSO","Antiviral","Microbiology","Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.",253.26,"39809-25-1",{"v":34,"d":"34.00"},134.25,{"v":1,"d":"1.00"},3.95,"http://selleckchem.com/products/penciclovir.html","C10H15N5O3","free base","BRL-39123, VSA 671,NSC-759624","NC1=NC(=O)C2=C(N1)[N](CCC(CO)CO)C=N2",-1.533,3,4,5]
["S4185","Tiratricol","h4","L3000-18","in 10mM DMSO","THR","Metabolism","Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.",621.93,"51-24-1",{"v":100,"d":"100.00"},160.79,"<1","N/A","http://selleckchem.com/products/tiratricol.html","C14H9I3O4","free base","triiodothyroacetic acid","OC(=O)CC1=CC(=C(OC2=CC=C(O)C(=C2)I)C(=C1)I)I",4.547,2,1,4]
["S4186","Domiphen Bromide","a5","L3000-18","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Domiphen bromide (NSC-39415) is a quaternary ammonium antiseptic with actions as a cationic surfactant.",414.46,"538-71-6",{"v":83,"d":"83.00"},200.26,{"v":83,"d":"83.00"},200.26,"http://selleckchem.com/products/domiphen-bromide.html","C22H40NO.Br","free base","NSC-39415","[Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1",3.157,1,0,15]
["S4187","Salicylanilide","b5","L3000-18","in 10mM DMSO","Fungal,Integrase,Reverse Transcriptase","Microbiology","Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.",213.23,"87-17-2",{"v":43,"d":"43.00"},201.66,"<1","N/A","http://selleckchem.com/products/salicylanilide.html","C13H11NO2","free base","WR10019,2-Hydroxybenzanilide","OC1=CC=CC=C1C(=O)NC2=CC=CC=C2",2.372,1,2,2]
["S4188","Sasapyrine","c5","L3000-18","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.",258.23,"552-94-3",{"v":52,"d":"52.00"},201.37,"<1","N/A","http://selleckchem.com/products/sasapyrine.html","C14H10O5","free base","NSC-49171,Salsalate","OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O",2.649,3,1,4]
["S4190","Cinchophen","d5","L3000-18","in 10mM DMSO","Others","Others","Cinchophen(Cinconal) is an analgesic drug that is frequently used to treat gout.",249.26,"132-60-5",{"v":50,"d":"50.00"},200.59,"<1","N/A","http://selleckchem.com/products/cinchophen.html","C16H11NO2","free base","Cinconal","OC(=O)C1=C2C=CC=CC2=NC(=C1)C3=CC=CC=C3",3.593,2,0,2]
["S4192","Chlorquinaldol","e5","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Chlorquinaldol(Chloquinan) is an antimicrobial agent used for local antisepsy.",228.07,"72-80-0",{"v":46,"d":"46.00"},201.69,"<1","N/A","http://selleckchem.com/products/chlorquinaldol.html","C10H7Cl2NO","free base","Chloquinan","CC1=CC=C2C(=CC(=C(O)C2=N1)Cl)Cl",3.385,1,1,0]
["S4194","Azaguanine-8","f5","L3000-18","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.",152.11,"134-58-7",{"v":6,"d":"6.00"},39.45,"<1","N/A","http://selleckchem.com/products/azaguanine-8.html","C4H4N6O","free base","NSC-749, SF-337, SK 1150","NC1=NC2=C(N=N[NH]2)C(=O)N1",-0.852,4,3,0]
["S4195","Broxyquinoline","g5","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Broxyquinoline(Dibromohydroxyquinoline) is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.",302.95,"521-74-4",{"v":17,"d":"17.00"},56.11,"<1","N/A","http://selleckchem.com/products/broxyquinoline.html","C9H5Br2NO","free base","Dibromohydroxyquinoline","OC1=C2N=CC=CC2=C(Br)C=C1Br",3.271,1,1,0]
["S4196","Ethacridine lactate monohydrate","h5","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Ethacridine lactate monohydrate(Acrinol monohydrat) is an aromatic organic compound based on acridine used as an antiseptic agent.",361.39,"6402-23-9",{"v":72,"d":"72.00"},199.23,{"v":5,"d":"5.00"},13.84,"http://selleckchem.com/products/ethacridine-lactate-monohydrate.html","C15H15N3O.C3H6O3.H2O","Lactate","Acrinol monohydrat","O.CCOC1=CC2=C(N)C3=CC=C(N)C=C3N=C2C=C1.CC(O)C(O)=O",1.592,3,3,3]
["S4197","Bemegride","a6","L3000-18","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Bemegride(Bemegrid,3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.",155.19,"64-65-3",{"v":31,"d":"31.00"},199.76,"<1","N/A","http://selleckchem.com/products/bemegride.html","C8H13NO2","free base","Bemegrid,3-Ethyl-3-methylglutarimide","CCC1(C)CC(=O)NC(=O)C1",0.578,2,1,1]
["S4201","Florfenicol","b6","L3000-18","in 10mM DMSO","Bacterial","Microbiology","Florfenicol (SCH-25298,(-)-Florfenicol) is a fluorinated synthetic analog of thiamphenicol with broad-spectrum, primarily bacteriostatic activity.",358.21,"73231-34-2",{"v":72,"d":"72.00"},{"v":201,"d":"201.00"},"<1","N/A","http://selleckchem.com/products/florfenicol.html","C12H14Cl2FNO4S","free base","SCH-25298,(-)-Florfenicol","C[S](=O)(=O)C1=CC=C(C=C1)C(O)C(CF)NC(=O)C(Cl)Cl",1.597,3,2,6]
["S4206","Cysteamine HCl","c6","L3000-18","in 10mM DMSO","Antioxidant","Metabolism","Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.",113.61,"156-57-0",{"v":23,"d":"23.00"},202.45,{"v":23,"d":"23.00"},202.45,"http://selleckchem.com/products/cysteamine-hcl.html","C2H7NS.HCl","Hydrochloride","Mercaptamine","Cl.NCCS",0.166,0,1,1]
["S4207","Clofibric Acid","d6","L3000-18","in 10mM DMSO","PPAR","Metabolism","Clofibric acid(Chlorofibrinic acid) is a PPARα agonist and hypolipidemic agent.",214.65,"882-09-7",{"v":43,"d":"43.00"},200.33,"<1","N/A","http://selleckchem.com/products/clofibric-acid.html","C10H11ClO3","free base","Chlorofibrinic acid","CC(C)(OC1=CC=C(Cl)C=C1)C(O)=O",2.755,2,0,3]
["S4208","Chromocarb","e6","L3000-18","in 10mM DMSO","Others","Others","Chromocarb(Atremon) is a vasoprotectant.",190.15,"4940-39-0",{"v":38,"d":"38.00"},199.84,"<1","N/A","http://selleckchem.com/products/chromocarb.html","C10H6O4","free base","Atremon","OC(=O)C1=CC(=O)C2=CC=CC=C2O1",1.247,3,0,1]
["S4210","Benzocaine","f6","L3000-18","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Benzocaine(ethyl 4-aminobenzoate) is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.",165.19,"94-09-7",{"v":33,"d":"33.00"},199.77,"<1","N/A","http://selleckchem.com/products/benzocaine.html","C9H11NO2","Free Base","ethyl 4-aminobenzoate","CCOC(=O)C1=CC=C(N)C=C1",1.287,2,1,3]
["S4212","Tenatoprazole","g6","L3000-18","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Tenatoprazole (TU-199,STU-Na) is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. Tenatoprazole labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of tenatoprazole is bound to the H(+),K(+)-ATPase.",{"v":346.4,"d":"346.40"},"113712-98-4",{"v":46,"d":"46.00"},132.79,"<1","N/A","http://selleckchem.com/products/tenatoprazole.html","C16H18N4O3S","free base","TU-199,STU-Na","COC1=CC=C2[NH]C(=NC2=N1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.488,6,1,5]
["S4213","Dirithromycin","h6","L3000-18","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Dirithromycin (LY-237216, ASE 136,Dynabac) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.",835.07,"62013-04-1",{"v":11,"d":"11.00"},13.17,"<1","N/A","http://selleckchem.com/products/dirithromycin.html","C42H78N2O14","free base","LY-237216, ASE 136,Dynabac","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C4NC(COCCOC)OC(C4C)C1(C)O",1.869,10,3,12]
["S4214","Sucralose","a7","L3000-18","in 10mM DMSO","Others","Others","Sucralose (E955,Trichloro Sucrose) is an artificial and noncaloric sweetener, not broken down by the body.",397.63,"56038-13-2",{"v":80,"d":"80.00"},201.19,{"v":80,"d":"80.00"},201.19,"http://selleckchem.com/products/sucralose.html","C12H19Cl3O8","free base","E955,Trichloro Sucrose","OCC1OC(OC2(CCl)OC(CCl)C(O)C2O)C(O)C(O)C1Cl",-0.697,3,5,5]
["S4216","Valnemulin HCl","b7","L3000-18","in 10mM DMSO","Bacterial","Microbiology","Valnemulin HCl is a broad-spectrum bacteriostatic agent inhibiting protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.",601.28,"133868-46-9",{"v":100,"d":"100.00"},166.31,{"v":100,"d":"100.00"},166.31,"http://selleckchem.com/products/valnemulin-hcl.html","C31H52N2O5S.HCl","Hydrochloride","N/A","Cl.CC(C)C(N)C(=O)NCC(C)(C)SCC(=O)OC1CC(C)(C=C)C(O)C(C)C23CCC(C)C1(C)C2C(=O)CC3",4.048,4,3,10]
["S4217","Liothyronine Sodium","c7","L3000-18","in 10mM DMSO","THR","Metabolism","Liothyronine Sodium(Cytomel) is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.",672.96,"55-06-1",{"v":100,"d":"100.00"},{"v":148.6,"d":"148.60"},"<1","N/A","http://selleckchem.com/products/liothyronine-sodium.html","C15H12I3NO4.Na","sodium","Cytomel","[Na+].NC(CC1=CC(=C(OC2=CC=C(O)C(=C2)I)C(=C1)I)I)C([O-])=O",2.452,1,2,5]
["S4221","Benzbromarone","d7","L3000-18","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Benzbromarone(Desuric) is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.",424.08,"3562-84-3",{"v":85,"d":"85.00"},200.43,"<1","N/A","http://selleckchem.com/products/benzbromarone.html","C17H12Br2O3","free base","Desuric","CCC1=C(C(=O)C2=CC(=C(O)C(=C2)Br)Br)C3=C(O1)C=CC=C3",5.604,2,1,3]
["S4223","Mevastatin","e7","L3000-18","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.",390.51,"73573-88-3",{"v":78,"d":"78.00"},199.74,"<1","N/A","http://selleckchem.com/products/mevastatin.html","C23H34O5","free base","ML-236B,Compactin","CCC(C)C(=O)OC1CCC=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",3.966,4,1,7]
["S4224","Erythritol","f7","L3000-18","in 10mM DMSO","Others","Others","Erythritol(meso-Erythritol) is a sugar alcohol used as low-calorie sweetener.",122.12,"149-32-6",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/erythritol.html","C4H10O4","free base","meso-Erythritol","OCC(O)C(O)CO",-1.919,0,4,3]
["S4225","Mexiletine HCl","g7","L3000-18","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Mexiletine HCl (KO1173,Mexitil) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.",215.72,"5370-01-4",{"v":43,"d":"43.00"},199.33,{"v":43,"d":"43.00"},199.33,"http://selleckchem.com/products/mexiletine-hcl.html","C11H17NO.HCl","Hydrochloride","KO1173,Mexitil","Cl.CC(N)COC1=C(C)C=CC=C1C",2.716,1,1,3]
["S4227","Fidaxomicin","h7","L3000-18","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fidaxomicin (OPT-80, PAR-101,Dificid) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.",1058.04,"873857-62-6",{"v":100,"d":"100.00"},94.51,"<1","N/A","http://selleckchem.com/products/fidaxomicin.html","C52H74Cl2O18","free base","OPT-80, PAR-101,Dificid","CCC1\\C=C(C)/C(O)C\\C=C\\C=C(COC2OC(C)C(OC(=O)C3=C(CC)C(=C(O)C(=C3O)Cl)Cl)C(O)C2OC)\\C(=O)OC(C\\C=C(C)\\C=C(C)\\C1OC4OC(C)(C)C(OC(=O)C(C)C)C(O)C4O)C(C)O",7.774,11,7,15]
["S4230","Oxaprozin","a8","L3000-18","in 10mM DMSO","COX","Metabolism","Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.",293.32,"21256-18-8",{"v":59,"d":"59.00"},201.15,"<1","N/A","http://selleckchem.com/products/oxaprozin.html","C18H15NO3","free base","WY-21743,nsc 310839","OC(=O)CCC1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3",{"v":3.59,"d":"3.590"},3,0,5]
["S4231","Pilocarpine HCl","b8","L3000-18","in 10mM DMSO","AChR","Neuronal Signaling","Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.",244.72,"54-71-7",{"v":48,"d":"48.00"},196.14,{"v":48,"d":"48.00"},196.14,"http://selleckchem.com/products/pilocarpine-hcl.html","C11H16N2O2.HCl","Hydrochloride","NSC 5746 HCl","Cl.CCC1C(COC1=O)CC2=CN=C[N]2C",1.347,3,0,3]
["S4232","Nithiamide","c8","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Nithiamide (CL 5279) is a non-5-nitroimidazole drugs.",187.18,"140-40-9",{"v":37,"d":"37.00"},197.67,"<1","N/A","http://selleckchem.com/products/nithiamide.html","C5H5N3O3S","free base","CL 5279","CC(=O)NC1=NC=C(S1)[N+]([O-])=O",-0.034,2,1,2]
["S4237","Primaquine Diphosphate","d8","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.",455.34,"63-45-6",{"v":91,"d":"91.00"},199.85,{"v":91,"d":"91.00"},199.85,"http://selleckchem.com/products/primaquine-diphosphate.html","C15H21N3O.2H3O4P","Diphosphate","N/A","COC1=CC(=C2N=CC=CC2=C1)NC(C)CCCN.O[P](O)(O)=O.O[P](O)(O)=O",1.062,2,2,6]
["S4238","Cepharanthine","e8","L3000-18","in 10mM DMSO","TNF-alpha","Apoptosis","Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.",606.71,"481-49-2",{"v":100,"d":"100.00"},164.82,"<1","N/A","http://selleckchem.com/products/cepharanthine.html","C37H38N2O6","free base","NSC-623442","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C(=C6OCOC6=C5)OC7=C(OC)C=C8CCN(C)C(CC(=C2)C=C1)C8=C7)C=C3",7.019,6,0,2]
["S4239","Bergapten","f8","L3000-18","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.",216.19,"484-20-8",{"v":5,"d":"5.00"},23.13,"<1","N/A","http://selleckchem.com/products/bergapten.html","C12H8O4","free base","N/A","COC1=C2C=COC2=CC3=C1C=CC(=O)O3",2.187,4,0,1]
["S4240","Doxylamine Succinate","g8","L3000-18","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.",388.46,"562-10-7",{"v":78,"d":"78.00"},200.79,{"v":78,"d":"78.00"},200.79,"http://selleckchem.com/products/doxylamine-succinate.html","C17H22N2O.C4H6O4","Succinate","N/A","CN(C)CCOC(C)(C1=CC=CC=C1)C2=CC=CC=N2.OC(=O)CCC(O)=O",-0.527,4,0,9]
["S4242","Cetrimonium Bromide (CTAB)","h8","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.",364.45,"57-09-0",{"v":5,"d":"5.00"},13.72,{"v":100,"d":"100.00"},274.39,"http://selleckchem.com/products/cetrimonium-bromide.html","C19H42N.Br","free base","N/A","[Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C",{"v":3.35,"d":"3.350"},0,0,15]
["S4243","Deoxycorticosterone acetate","a9","L3000-18","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.",{"v":372.5,"d":"372.50"},"56-47-3",{"v":11,"d":"11.00"},29.53,"<1","N/A","http://selleckchem.com/products/deoxycorticosterone-acetate.html","C23H32O4","free base","11-Deoxycorticosterone acetate, DOC acetate, Cortexone acetate","CC(=O)OCC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",3.567,4,0,4]
["S4244","Serotonin HCl","b9","L3000-18","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.",212.68,"153-98-0",{"v":42,"d":"42.00"},197.48,{"v":42,"d":"42.00"},197.48,"http://selleckchem.com/products/serotonin-hcl.html","C10H12N2O.HCl","Hydrochloride","5-HT HCl","Cl.NCCC1=C[NH]C2=CC=C(O)C=C12",{"v":1.69,"d":"1.690"},0,3,2]
["S4246","Tranylcypromine (2-PCPA) HCl","c9","L3000-18","in 10mM DMSO","MAO","Metabolism","Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.",169.65,"1986-47-6",{"v":33,"d":"33.00"},194.52,{"v":33,"d":"33.00"},194.52,"http://selleckchem.com/products/tranylcypromine-2-pcpa-hcl.html","C9H12ClN","Hydrochloride","SKF-385 HCl, Parnate,2-PCPA","Cl.NC1CC1C2=CC=CC=C2",2.309,0,1,1]
["S4249","Flopropione","d9","L3000-18","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist.",182.17,"2295-58-1",{"v":36,"d":"36.00"},197.62,"<1","N/A","http://selleckchem.com/products/flopropione.html","C9H10O4","free base","N/A","CCC(=O)C1=C(O)C=C(O)C=C1O",{"v":1.51,"d":"1.510"},1,3,2]
["S4250","Sulfamethoxypyridazine","e9","L3000-18","in 10mM DMSO","Anti-infection","Microbiology","Sulfamethoxypyridazine (CL 13494) is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.",{"v":280.3,"d":"280.30"},"80-35-3",{"v":56,"d":"56.00"},199.79,"<1","N/A","http://selleckchem.com/products/sulfamethoxypyridazine.html","C11H12N4O3S","free base","CL 13494","COC1=NN=C(N[S](=O)(=O)C2=CC=C(N)C=C2)C=C1",1.014,5,2,4]
["S4251","Phenothiazine","f9","L3000-18","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Phenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.",199.27,"92-84-2",{"v":40,"d":"40.00"},200.73,"<1","N/A","http://selleckchem.com/products/phenothiazine.html","C12H9NS","free base","ENT 38","N1C2=C(SC3=CC=CC=C13)C=CC=C2",3.668,0,1,0]
["S4253","Epinastine HCl","g9","L3000-18","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Epinastine (WAL-801CL) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.",285.77,"108929-04-0",{"v":57,"d":"57.00"},199.46,{"v":57,"d":"57.00"},199.46,"http://selleckchem.com/products/epinastine-hcl.html","C16H15N3.HCl","Hydrochloride","WAL-801CL HCl","Cl.NC1=NCC2N1C3=CC=CC=C3CC4=CC=CC=C24",3.164,1,1,0]
["S4255","Quinacrine 2HCl","h9","L3000-18","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective  phospholipase A2 inhibitor.",472.88,"69-05-6",{"v":14,"d":"14.00"},29.61,{"v":53,"d":"53.00"},112.08,"http://selleckchem.com/products/quinacrine-2hcl.html","C23H30ClN3O.2HCl","Dihydrochloride","Quinacrine dihydrochloride","Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",{"v":6.43,"d":"6.430"},2,1,9]
["S4256","Buspirone HCl","a10","L3000-18","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.",421.96,"33386-08-2",{"v":84,"d":"84.00"},199.07,{"v":84,"d":"84.00"},199.07,"http://selleckchem.com/products/buspirone-hcl.html","C21H31N5O2.HCl","Hydrochloride","Buspirone hydrochloride","Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)C4=NC=CC=N4",2.403,4,0,6]
["S4257","Alizapride HCl","b10","L3000-18","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.",351.83,"59338-87-3",{"v":42,"d":"42.00"},119.38,{"v":70,"d":"70.00"},198.96,"http://selleckchem.com/products/alizapride-hcl.html","C16H21N5O2.HCl","hydrochloride","Alizapride hydrochloride","Cl.COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)N=N[NH]2",2.253,4,2,6]
["S4259","Vilazodone HCl","c10","L3000-18","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and  a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.",477.99,"163521-08-2",{"v":96,"d":"96.00"},200.84,"<1","N/A","http://selleckchem.com/products/vilazodone-hcl.html","C26H27N5O2.HCl","Hydrochloride","EMD68843,SB659746A","Cl.NC(=O)C1=CC2=C(O1)C=CC(=C2)N3CCN(CCCCC4=C[NH]C5=C4C=C(C=C5)C#N)CC3",4.918,2,2,7]
["S4260","Tamibarotene","d10","L3000-18","in 10mM DMSO","Retinoid Receptor","Metabolism","Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.",351.44,"94497-51-5",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://selleckchem.com/products/tamibarotene.html","C22H25NO3","free base","Am 80","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S4263","Efaproxiral Sodium","e10","L3000-18","in 10mM DMSO","ROS","Immunology & Inflammation","Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. Efaproxiral Sodium is used for brain metastases originating from breast cancer.",363.38,"170787-99-2",{"v":73,"d":"73.00"},200.89,{"v":73,"d":"73.00"},200.89,"http://selleckchem.com/products/efaproxiral-sodium.html","C20H23NO4.Na","Sodium salt","RSR13 Sodium","[Na+].CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(OC(C)(C)C([O-])=O)C=C2)C",2.408,2,1,6]
["S4265","Nicaraven","f10","L3000-18","in 10mM DMSO","Others","Others","Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.",284.31,"79455-30-4",{"v":57,"d":"57.00"},200.49,{"v":57,"d":"57.00"},200.49,"http://selleckchem.com/products/nicaraven.html","C15H16N4O2","free base","N/A","CC(CNC(=O)C1=CN=CC=C1)NC(=O)C2=CN=CC=C2",-0.029,4,2,5]
["S4266","Brimonidine Tartrate","g10","L3000-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Brimonidine Tartrate(UK 1434 Tartrate) is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.",442.22,"70359-46-5",{"v":88,"d":"88.00"},{"v":199,"d":"199.00"},{"v":75,"d":"75.00"},{"v":169.6,"d":"169.60"},"http://selleckchem.com/products/brimonidine-tartrate.html","C15H16BrN5O6","Tartrate","UK 1434 Tartrate","OC(C(O)C(O)=O)C(O)=O.BrC1=C2N=CC=NC2=CC=C1NC3=NCCN3",-0.426,5,4,5]
["S4267","Diacerein","h10","L3000-18","in 10mM DMSO","Interleukins","Immunology & Inflammation","Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.",368.29,"13739-02-1",{"v":48,"d":"48.00"},130.33,"<1","N/A","http://selleckchem.com/products/diacerein.html","C19H12O8","free base","N/A","CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3OC(C)=O)C(O)=O)C2=O",1.973,7,0,5]
["S4268","Flufenamic acid","a11","L3000-18","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.",281.23,"530-78-9",{"v":56,"d":"56.00"},199.13,"<1","N/A","http://selleckchem.com/products/flufenamic-acid.html","C14H10F3NO2","free base","N/A","OC(=O)C1=CC=CC=C1NC2=CC=CC(=C2)C(F)(F)F",3.952,1,1,4]
["S4269","Vinorelbine ditartrate (KW-2307)","b11","L3000-18","in 10mM DMSO","Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.",1079.11,"125317-39-7",{"v":100,"d":"100.00"},92.67,{"v":100,"d":"100.00"},92.67,"http://selleckchem.com/products/vinorelbine-tartrate.html","C45H54N4O8.2C4H6O6","ditartrate","Nor-5'-anhydrovinblastine ditartrate,KW-2307","CCC1=CC2CN(C1)CC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC.OC(C(O)C(O)=O)C(O)=O.OC(C(O)C(O)=O)C(O)=O",{"v":-4,"d":"-4.000"},11,5,16]
["S4270","Oxiracetam","c11","L3000-18","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Oxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.",158.16,"62613-82-5",{"v":31,"d":"31.00"},{"v":196,"d":"196.00"},{"v":31,"d":"31.00"},{"v":196,"d":"196.00"},"http://selleckchem.com/products/oxiracetam.html","C6H10N2O3","free base","ISF 2522","NC(=O)CN1CC(O)CC1=O",-2.143,2,2,2]
["S4277","Bambuterol HCl","d11","L3000-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride) is a potent β-adrenoceptor agonist, used in the treatment of asthma.",{"v":403.9,"d":"403.90"},"81732-46-9",{"v":80,"d":"80.00"},198.07,{"v":72,"d":"72.00"},178.26,"http://selleckchem.com/products/bambuterol-hci.html","C18H29N3O5.HCl","Hydrochloride","Bambuterol hydrochloride,KWD-2183 hydrochloride","Cl.CN(C)C(=O)OC1=CC(=CC(=C1)OC(=O)N(C)C)C(O)CNC(C)(C)C",2.109,4,2,8]
["S4278","Carteolol HCl","e11","L3000-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Carteolol HCl(Carteolol hydrochloride,OPC-1085 hydrochloride) is a β-adrenoceptor antagonist, used for the treatment of glaucoma.",328.83,"51781-21-6",{"v":65,"d":"65.00"},197.67,{"v":65,"d":"65.00"},197.67,"http://selleckchem.com/products/carteolol-hci.html","C16H25ClN2O3","Hydrochloride","Carteolol hydrochloride,OPC-1085 hydrochloride","Cl.CC(C)(C)NCC(O)COC1=C2CCC(=O)NC2=CC=C1",1.664,2,3,6]
["S4280","Meclofenoxate (Centrophenoxine) HCl","f11","L3000-18","in 10mM DMSO","Transferase","Metabolism","Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.",294.17,"3685-84-5",{"v":58,"d":"58.00"},197.16,{"v":58,"d":"58.00"},197.16,"http://selleckchem.com/products/meclofenoxate-centrophenoxine-hci.html","C12H17Cl2NO3","Hydrochloride","Centrophenoxine","Cl.CN(C)CCOC(=O)COC1=CC=C(Cl)C=C1",2.705,3,0,7]
["S4282","Nelfinavir (AG 1343) Mesylate","g11","L3000-18","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.",663.89,"159989-65-8",{"v":100,"d":"100.00"},150.63,"<1","N/A","http://selleckchem.com/products/nelfinavir-mesylate.html","C33H49N3O7S2","Mesylate","Viracept, AG1343","CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(O)CN3CC4CCCCC4CC3C(=O)NC(C)(C)C.C[S](O)(=O)=O",4.871,2,4,10]
["S4283","Cyclobenzaprine HCl","h11","L3000-18","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cyclobenzaprine HCl(Cyclobenzaprine hydrochloride) is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms; A 5-HT2 receptor antagonist.",311.85,"6202-23-9",{"v":62,"d":"62.00"},198.81,{"v":62,"d":"62.00"},198.81,"http://selleckchem.com/products/cyclobenzaprine-hci.html","C20H22ClN","Hydrochloride","Cyclobenzaprine hydrochloride","Cl.CN(C)CCC=C1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",4.709,0,0,3]
["S4285","Ospemifene","a2","L3000-19","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ospemifene(FC-1271a) is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.",378.89,"128607-22-7",{"v":75,"d":"75.00"},197.95,"<1","N/A","http://selleckchem.com/products/ospemifene.html","C24H23ClO2","free base","FC-1271a","OCCOC1=CC=C(C=C1)\\C(=C(\\CCCl)C2=CC=CC=C2)C3=CC=CC=C3",{"v":5.62,"d":"5.620"},1,1,8]
["S4288","Chloroambucil","b2","L3000-19","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.",304.21,"305-03-3",{"v":60,"d":"60.00"},197.23,"<1","N/A","http://selleckchem.com/products/chloroambucil.html","C14H19Cl2NO2","free base","Chlorambucil,CB-1348,WR-139013","OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl",3.899,1,0,9]
["S4289","Metoclopramide HCl","c2","L3000-19","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.",336.26,"7232-21-5",{"v":67,"d":"67.00"},199.25,{"v":67,"d":"67.00"},199.25,"http://selleckchem.com/products/metoclopramide-hcl.html","C14H23Cl2N3O2","Hydrochloride","Metoclopramide hydrochloride","Cl.CCN(CC)CCNC(=O)C1=CC(=C(N)C=C1OC)Cl",2.157,2,2,7]
["S4291","Labetalol HCl","d2","L3000-19","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Labetalol HCl(AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W) is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.",364.87,"32780-64-6",{"v":72,"d":"72.00"},197.33,{"v":8,"d":"8.00"},21.93,"http://selleckchem.com/products/labetalol-hcl.html","C19H25ClN2O3","Hydrochloride","AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W","Cl.CC(CCC1=CC=CC=C1)NCC(O)C2=CC(=C(O)C=C2)C(N)=O",2.737,1,4,8]
["S4292","Diphenidol HCl","e2","L3000-19","in 10mM DMSO","AChR","Neuronal Signaling","Diphenidol HCl(Diphenidol hydrochloride) is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.",345.91,"3254-89-5",{"v":69,"d":"69.00"},199.47,{"v":13,"d":"13.00"},37.58,"http://selleckchem.com/products/diphenidol-hcl.html","C21H28ClNO","Hydrochloride","Diphenidol hydrochloride","Cl.OC(CCCN1CCCCC1)(C2=CC=CC=C2)C3=CC=CC=C3",4.774,0,0,6]
["S4294","Procainamide HCl","f2","L3000-19","in 10mM DMSO","DNA Methyltransferase,Sodium Channel","Transmembrane Transporters","Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.",271.79,"614-39-1",{"v":54,"d":"54.00"},198.68,{"v":54,"d":"54.00"},198.68,"http://selleckchem.com/products/procainamide-hcl.html","C13H22ClN3O","Hydrochloride","N/A","Cl.CCN(CC)CCNC(=O)C1=CC=C(N)C=C1",1.509,1,2,6]
["S4295","Meclofenamate Sodium","g2","L3000-19","in 10mM DMSO","COX,FTO","Neuronal Signaling","Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.",318.13,"6385-02-0",{"v":63,"d":"63.00"},198.03,{"v":63,"d":"63.00"},198.03,"http://selleckchem.com/products/meclofenamate-sodium.html","C14H11Cl2NO2.Na","Sodium Salt","CI 583","CC1=C(Cl)C(=C(Cl)C=C1)NC2=CC=CC=C2C(=O)O[Na]",4.915,2,1,4]
["S4297","Mupirocin","h2","L3000-19","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.",500.62,"12650-69-0",{"v":100,"d":"100.00"},199.75,{"v":46,"d":"46.00"},91.89,"http://selleckchem.com/products/mupirocin.html","C26H44O9","free base","BRL-4910A,Pseudomonic acid","CC(O)C(C)C1OC1CC2COC(C\\C(C)=C\\C(=O)OCCCCCCCCC(O)=O)C(O)C2O",2.739,5,3,17]
["S4299","Dicoumarol","a3","L3000-19","in 10mM DMSO","PDHK","Metabolism","Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor,and used as an anticoagulant by interfering with the metabolism of vitamin K.",336.29,"66-76-2",{"v":67,"d":"67.00"},199.23,"<1","N/A","http://selleckchem.com/products/dicoumarol.html","C19H12O6","free base","Dicumarol","OC1=C(CC2=C(O)C3=C(OC2=O)C=CC=C3)C(=O)OC4=CC=CC=C14",2.789,4,2,2]
["S4303","9-Aminoacridine","b3","L3000-19","in 10mM DMSO","Anti-infection","Microbiology","9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.",194.23,"90-45-9",{"v":38,"d":"38.00"},195.64,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/9-aminoacridine.html","C13H10N2","free base","Aminacrine","NC1=C2C=CC=CC2=NC3=CC=CC=C13",2.606,1,1,0]
["S4307","Auranofin","c3","L3000-19","in 10mM DMSO","Bacterial,Thioredoxin Reductase","Microbiology","Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.",678.48,"34031-32-8",{"v":100,"d":"100.00"},147.39,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/auranofin.html","C20H34AuO9PS","Free Base","Ridaura, SKF39162","CCP(|[Au]SC1OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O)(CC)CC",1.407,9,0,14]
["S4308","Benzthiazide","d3","L3000-19","in 10mM DMSO","Others","Others","Benzthiazide is a thiazide diuretic, promoting water loss from the body.",431.94,"91-33-8",{"v":86,"d":"86.00"},{"v":199.1,"d":"199.10"},"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/benzthiazide.html","C15H14ClN3O4S3","Free Base","Benzothiazide","N[S](=O)(=O)C1=CC2=C(C=C1Cl)N=C(CSCC3=CC=CC=C3)N[S]2(=O)=O",1.966,5,2,5]
["S4309","Bromocriptine Mesylate","e3","L3000-19","in 10mM DMSO","Others","Others","Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.",{"v":750.7,"d":"750.70"},"22260-51-1",{"v":100,"d":"100.00"},133.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bromocriptine-mesylate.html","C32H40BrN5O5.CH4O3S","Mesylate","N/A","CC(C)CC1N2C(=O)C(NC(=O)C3CN(C)C4CC5=C(Br)[NH]C6=C5C(=CC=C6)C4=C3)(OC2(O)C7CCCN7C1=O)C(C)C.C[S](O)(=O)=O",3.949,4,2,5]
["S4316","Clopamide","f3","L3000-19","in 10mM DMSO","Others","Others","Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do.",345.84,"636-54-4",{"v":69,"d":"69.00"},199.51,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/clopamide.html","C14H20ClN3O3S","Free Base","N/A","CC1CCCC(C)N1NC(=O)C2=CC=C(Cl)C(=C2)[S](N)(=O)=O",1.793,3,2,3]
["S4317","Clorgyline HCl","g3","L3000-19","in 10mM DMSO","MAO","Others","Clorgiline is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A).",308.63,"17780-75-5",{"v":62,"d":"62.00"},200.89,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/clorgyline-hcl.html","C13H15Cl2NO.HCl","hydrochloride","N/A","Cl.CN(CCCOC1=CC=C(Cl)C=C1Cl)CC#C",4.917,1,0,6]
["S4330","Isoetharine Mesylate","h3","L3000-19","in 10mM DMSO","Others","Others","Isoetharine is a selective beta2-adrenergic receptor agonist, which gives quick relief for bronchospasm and asthma.",335.42,"7279-75-6",{"v":67,"d":"67.00"},199.75,{"v":67,"d":"67.00"},199.75,"http://www.selleckchem.com/products/isoetharine-mesylate.html","C14H25NO6S","mesylate","N/A","CCC(NC(C)C)C(O)C1=CC=C(O)C(=C1)O.C[S](O)(=O)=O",1.586,0,4,5]
["S4334","Mesoridazine Besylate","a4","L3000-19","in 10mM DMSO","Others","Others","N/A",544.75,"32672-69-8",{"v":100,"d":"100.00"},183.57,{"v":100,"d":"100.00"},183.57,"http://www.selleckchem.com/products/mesoridazine-besylate.html","C27H32N2O4S3","besylate","N/A","CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)[S](C)=O.O[S](=O)(=O)C5=CC=CC=C5",5.614,1,0,5]
["S4335","Metaproterenol Sulfate","b4","L3000-19","in 10mM DMSO","Others","Others","N/A",520.59,"5874-97-5",{"v":100,"d":"100.00"},192.09,{"v":100,"d":"100.00"},192.09,"http://www.selleckchem.com/products/metaproterenol-sulfate.html","C22H36N2O10S","sulfate","Orciprenaline Sulfate","CC(C)NCC(O)C1=CC(=CC(=C1)O)O.CC(C)NCC(O)C2=CC(=CC(=C2)O)O.O[S](O)(=O)=O",1.591,0,8,8]
["S4336","Metaraminol Bitartrate","c4","L3000-19","in 10mM DMSO","Others","Others","N/A",317.29,"33402-03-8",{"v":63,"d":"63.00"},198.56,{"v":63,"d":"63.00"},198.56,"http://www.selleckchem.com/products/metaraminol-bitartrate.html","C13H19NO8","bitartrate","Metaradrine Bitartrate","CC(N)C(O)C1=CC=CC(=C1)O.OC(C(O)C(O)=O)C(O)=O",-3.582,2,5,5]
["S4338","Methoxamine HCl","d4","L3000-19","in 10mM DMSO","Others","Others","Methoxamine is an α1-adrenergic receptor agonist, it induces vasoconstriction of skin and splanchnic blood vessels.",247.72,"61-16-5",{"v":50,"d":"50.00"},201.84,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/methoxamine-hcl.html","C11H17NO3.HCl","Hydrochloride","Vasoxine HCl","Cl.COC1=CC(=C(OC)C=C1)C(O)C(C)N",1.151,2,2,4]
["S4339","Meticrane","e4","L3000-19","in 10mM DMSO","Chloride Channel,Sodium Channel","Transmembrane Transporters","Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.",275.34,"1084-65-7",{"v":55,"d":"55.00"},199.75,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/meticrane.html","C10H13NO4S2","Free Base","N/A","CC1=C(C=C2C(=C1)CCC[S]2(=O)=O)[S](N)(=O)=O",1.078,4,1,1]
["S4342","Nialamide","f4","L3000-19","in 10mM DMSO","MAO","Others","Nialamide is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic.",298.34,"51-12-7",{"v":59,"d":"59.00"},197.76,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/nialamide.html","C16H18N4O2","Free Base","N/A","O=C(CCNNC(=O)C1=CC=NC=C1)NCC2=CC=CC=C2",0.287,3,3,7]
["S4344","Oxprenolol HCl","g4","L3000-19","in 10mM DMSO","Adrenergic Receptor","Others","Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity.",301.81,"6452-73-9",{"v":60,"d":"60.00"},{"v":198.8,"d":"198.80"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/oxprenolol-hcl.html","C15H23NO3.HCl","hydrochloride","N/A","Cl.CC(C)NCC(O)COC1=CC=CC=C1OCC=C",2.614,2,2,9]
["S4345","Pentoxifylline","h4","L3000-19","in 10mM DMSO","PDE","Metabolism","Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.",278.31,"6493-05-6",{"v":55,"d":"55.00"},197.62,{"v":55,"d":"55.00"},197.62,"http://www.selleckchem.com/products/pentoxifylline.html","C13H18N4O3","Free Base","N/A","C[N]1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C",0.507,4,0,5]
["S4353","Terfenadine","a5","L3000-19","in 10mM DMSO","Calcium Channel,Caspase,Histamine Receptor,NCX,Potassium Channel","Transmembrane Transporters","Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.  Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.",471.67,"50679-08-8",{"v":94,"d":"94.00"},199.29,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/terfenadine.html","C32H41NO2","Free Base","N/A","CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",6.498,0,1,9]
["S4354","Thiostrepton","b5","L3000-19","in 10mM DMSO","Others","Others","Thiostrepton (Alaninamide, Bryamycin, Thiactin) is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes.",1664.89,"1393-48-2",{"v":100,"d":"100.00"},60.06,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/thiostrepton.html","C72H85N19O18S5","Free Base","Alaninamide, Bryamycin, Thiactin","CCC(C)C1NC2C=CC3=C(C=C(N=C3C2O)C(=O)OC(C)C4NC(=O)C5=CSC(=N5)C(NC(=O)C6CSC(=N6)\\C(NC(=O)C(NC(=O)C7=CSC(=N7)C8(CCC(=NC8C9=CSC4=N9)C%10=NC(=CS%10)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)=C\\C)C(C)(O)C(C)O)C(C)O",-1.361,20,16,12]
["S4358","Pimozide","c5","L3000-19","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor,Dopamine Receptor,STAT","Neuronal Signaling","Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.",461.55,"2062-78-4",{"v":92,"d":"92.00"},199.33,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pimozide.html","C28H29F2N3O","Free Base","Orap, R6238","FC1=CC=C(C=C1)C(CCCN2CCC(CC2)N3C(=O)NC4=CC=CC=C34)C5=CC=C(F)C=C5",5.521,1,1,7]
["S4361","Cinoxacin","d5","L3000-19","in 10mM DMSO","Bacterial","Others","Cinoxacin is a chemotherapeutic agent that inhibits bacterial DNA synthesis.",262.22,"28657-80-9",{"v":7,"d":"7.00"},{"v":26.7,"d":"26.70"},"N/A","N/A","http://selleckchem.com/products/cinoxacin.html","C12H10N2O5","Free Base","N/A","CCN1N=C(C(O)=O)C(=O)C2=C1C=C3OCOC3=C2","N/A","N/A","N/A","N/A"]
["S4362","Glafenine HCl","e5","L3000-19","in 10mM DMSO","Others","Others","Glafenine is an anthranilic acid derivative with analgesic properties, which has been used previously in the treatment of pain.",409.26,"65513-72-6",{"v":81,"d":"81.00"},197.92,{"v":7,"d":"7.00"},{"v":17.1,"d":"17.10"},"http://www.selleckchem.com/products/glafenine-hcl.html","C19H18Cl2N2O4","hydrochloride","N/A","Cl.OCC(O)COC(=O)C1=CC=CC=C1NC2=CC=NC3=CC(=CC=C23)Cl",3.418,3,3,7]
["S4367","Suxibuzone","f5","L3000-19","in 10mM DMSO","Others","Others","Suxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone, and is commonly used in horses.",438.47,"27470-51-5",{"v":88,"d":"88.00"},{"v":200.7,"d":"200.70"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/suxibuzone.html","C24H26N2O6","Free Base","N/A","CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3",3.504,5,0,11]
["S4373","Dicyclomine HCl","g5","L3000-19","in 10mM DMSO","Others","Others","Dicyclomine is an anticholinergic drug, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle).",345.95,"67-92-5",{"v":22,"d":"22.00"},63.59,{"v":69,"d":"69.00"},199.45,"http://www.selleckchem.com/products/dicyclomine-hcl.html","C19H36ClNO2","Hydrochloride","Dicycloverine HCl","Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2",5.487,2,0,8]
["S4375","Mepenzolate Bromide","h5","L3000-19","in 10mM DMSO","Others","Others","Mepenzolate is a post-ganglionic parasympathetic inhibitor, it decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon.",420.34,"76-90-4",{"v":41,"d":"41.00"},199.34,{"v":1,"d":"1.00"},4.86,"http://www.selleckchem.com/products/mepenzolate-bromide.html","C21H26BrNO3","bromide","N/A","[Br-].C[N+]1(C)CCC(CC1)OC(=O)C(O)(C2=CC=CC=C2)C3=CC=CC=C3",-1.048,2,0,5]
["S4381","Proadifen HCl","a6","L3000-19","in 10mM DMSO","CYP450","Others","Proadifen is an inhibitor of cytochrome P450 enzymes, preventing some types of drug metabolism.",390.01,"62-68-0",{"v":77,"d":"77.00"},197.43,{"v":77,"d":"77.00"},197.43,"http://www.selleckchem.com/products/proadifen-hcl.html","C23H32ClNO2","hydrochloride","SKF 525-A HCl","Cl.CCCC(C(=O)OCCN(CC)CC)(C1=CC=CC=C1)C2=CC=CC=C2",5.762,2,0,11]
["S4382","Pyrilamine Maleate","b6","L3000-19","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Pyrilamine Maleate (Mepyramine)is a histamine H1 receptor inverse agonist, it binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling.",401.46,"59-33-6",{"v":80,"d":"80.00"},199.27,{"v":80,"d":"80.00"},199.27,"https://www.selleckchem.com/products/pyrilamine-maleate.html","C17H23N3O1.C4H4O4","maleate","Mepyramine Maleate","COC1=CC=C(CN(CCN(C)C)C2=CC=CC=N2)C=C1.OC(=O)\\C=C/C(O)=O",{"v":0.09,"d":"0.090"},4,0,9]
["S4387","Bendroflumethiazide","c6","L3000-19","in 10mM DMSO","Others","Others","N/A",421.41,"73-48-3",{"v":85,"d":"85.00"},{"v":201.7,"d":"201.70"},"N/A","N/A","http://selleckchem.com/products/bendroflumethiazide.html","C15H14F3N3O4S2","sulfonamide","Bendrofluazide","N[S](=O)(=O)C1=CC2=C(NC(CC3=CC=CC=C3)N[S]2(=O)=O)C=C1C(F)(F)F","N/A","N/A","N/A","N/A"]
["S4394","Clofoctol","d6","L3000-19","in 10mM DMSO","Others","Others","N/A",365.34,"37693-01-9",{"v":73,"d":"73.00"},199.81,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/clofoctol.html","C21H26Cl2O","Free Base","N/A","CC(C)(C)CC(C)(C)C1=CC(=C(O)C=C1)CC2=CC=C(Cl)C=C2Cl",7.662,0,1,5]
["S4396","Digoxigenin","e6","L3000-19","in 10mM DMSO","Others","Others","N/A",390.51,"1672-46-4",{"v":78,"d":"78.00"},199.74,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/digoxigenin.html","C23H34O5","Free Base","Lanadigigenin","CC12CCC(O)CC1CCC3C2CC(O)C4(C)C(CCC34O)C5=CC(=O)OC5",2.276,2,2,1]
["S4398","Isoxicam","f6","L3000-19","in 10mM DMSO","Others","Others","N/A",335.34,"34552-84-6",{"v":17,"d":"17.00"},50.69,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/isoxicam.html","C14H13N3O5S","Free Base","N/A","CN1C(=C(O)C2=CC=CC=C2[S]1(=O)=O)C(=O)NC3=NOC(=C3)C",0.251,5,2,2]
["S4401","Nifenazone","g6","L3000-19","in 10mM DMSO","Others","Others","N/A",308.33,"2139-47-1",{"v":17,"d":"17.00"},55.14,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/nifenazone.html","C17H16N4O2","Free Base","N/A","CN1N(C2=CC=CC=C2)C(=O)C(=C1C)NC(=O)C3=CC=CN=C3",0.556,3,1,3]
["S4404","Pasiniazid","h6","L3000-19","in 10mM DMSO","Bacterial","Microbiology","Pasiniazid(Paraniazide,Pasiniazide) is a composition of isoniazid and 4-aminosalicylic acid, used to treat tuberculosis patients.",290.27,"2066-89-9",{"v":58,"d":"58.00"},199.81,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pasiniazid.html","C6H7N3O.C7H7NO3","Isonicotinic","Paraniazide,Pasiniazide","NNC(=O)C1=CC=NC=C1.NC2=CC(=C(C=C2)C(O)=O)O",{"v":-0.34,"d":"-0.340"},3,4,2]
["S4406","Pindolol","a7","L3000-19","in 10mM DMSO","5-HT Receptor","Others","N/A",248.32,"13523-86-9",{"v":50,"d":"50.00"},201.35,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/pindolol.html","C14H20N2O2","Free Base","N/A","CC(C)NCC(O)COC1=C2C=C[NH]C2=CC=C1",1.925,1,3,6]
["S4408","Procodazole","b7","L3000-19","in 10mM DMSO","Antiviral,Bacterial","Microbiology","Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.",{"v":190.2,"d":"190.20"},"23249-97-0",{"v":38,"d":"38.00"},199.79,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/procodazole.html","C10H10N2O2","Free Base","Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid","OC(=O)CCC1=NC2=C([NH]1)C=CC=C2",1.451,2,1,3]
["S4416","Trimipramine Maleate","c7","L3000-19","in 10mM DMSO","Others","Others","N/A",410.51,"521-78-8",{"v":82,"d":"82.00"},199.75,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/trimipramine-maleate.html","C24H30N2O4","maleate","N/A","CC(CN(C)C)CN1C2=C(CCC3=CC=CC=C13)C=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":1.84,"d":"1.840"},2,0,6]
["S4502","Eltrombopag","d7","L3000-19","in 10mM DMSO","TpoR","Immunology & Inflammation","Eltrombopag (SB-497115), a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP).",442.47,"496775-61-2",{"v":26,"d":"26.00"},58.76,"<1","N/A","http://selleckchem.com/products/eltrombopag.html","C25H22N4O4","Free Base","SB-497115","CC1=CC=C(C=C1C)N2N=C(C)C(=N/NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(O)=O)/C2=O",4.702,4,2,5]
["S4504","6-Mercaptopurine (6-MP) Monohydrate","e7","L3000-19","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",170.19,"6112-76-1",{"v":34,"d":"34.00"},199.78,"<1","N/A","http://selleckchem.com/products/6-mercaptopurine-6-mp-monohydrate.html","C5H6N4OS","free base","N/A","O.S=C1N=CNC2=C1[NH]C=N2",{"v":0.16,"d":"0.160"},2,2,0]
["S4505","Vinblastine (NSC-49842) sulfate","f7","L3000-19","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1","N/A","http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4506","Acetazolamide","g7","L3000-19","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).",222.25,"59-66-5",{"v":44,"d":"44.00"},197.98,"<1","N/A","http://selleckchem.com/products/acetazolamide.html","C4H6N4O3S2","free base","Diamox","CC(=O)NC1=NN=C(S1)[S](N)(=O)=O",-1.329,5,2,2]
["S4507","17-Hydroxyprogesterone","h7","L3000-19","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.",330.46,"68-96-2",{"v":66,"d":"66.00"},199.72,"<1","N/A","http://selleckchem.com/products/17-hydroxyprogesterone.html","C21H30O3","free base","N/A","CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",3.124,2,0,1]
["S4509","4-Aminoantipyrine","a8","L3000-19","in 10mM DMSO","COX","Immunology & Inflammation","4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.",203.24,"83-07-8",{"v":40,"d":"40.00"},196.81,{"v":40,"d":"40.00"},196.81,"http://selleckchem.com/products/4-aminoantipyrine.html","C11H13N3O","free base","Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A,  Minoazophene, Aminoazophene,  Aminoantipyrin","CN1N(C2=CC=CC=C2)C(=O)C(=C1C)N",0.021,1,1,1]
["S4512","Aceglutamide","b8","L3000-19","in 10mM DMSO","Others","Others","Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability.",188.18,"2490-97-3",{"v":37,"d":"37.00"},196.62,{"v":37,"d":"37.00"},196.62,"http://selleckchem.com/products/aceglutamide.html","C7H12N2O4","free base","α-N-Acetyl-L-glutamine, N2-Acetylglutamine","CC(=O)NC(CCC(N)=O)C(O)=O",-1.587,3,2,5]
["S4514","Acetylleucine","c8","L3000-19","in 10mM DMSO","Others","Others","Acetylleucine (N-acetyl-L-leucine) is a drug used in the treatment of vertigo.",173.21,"99-15-0",{"v":34,"d":"34.00"},196.29,"<1","N/A","http://selleckchem.com/products/acetylleucine.html","C8H15NO3","free base","N-acetyl-L-leucine","CC(C)CC(NC(C)=O)C(O)=O",0.571,2,1,4]
["S4516","(+)-Camphor","d8","L3000-19","in 10mM DMSO","Fungal,TRP Channel","Transmembrane Transporters","Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1  and TRPV3.",152.23,"464-49-3",{"v":30,"d":"30.00"},197.07,"<1","N/A","http://selleckchem.com/products/positive-rotation-camphor.html","C10H16O","free base","D-(+)-camphor, (1R)-(+)-camphor","CC1(C)C2CCC1(C)C(=O)C2",2.075,1,0,0]
["S4517","Cefotaxime sodium","e8","L3000-19","in 10mM DMSO","Antibiotics,Antibiotics for Plant Cell Culture,Bacterial","Microbiology","Cefotaxime sodium(HR-756) salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria.",477.45,"64485-93-4",{"v":95,"d":"95.00"},198.97,{"v":95,"d":"95.00"},198.97,"http://selleckchem.com/products/cefotaxime-sodium.html","C16H17N5O7S2.Na","Sodium Salt","HR-756","[Na+].CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)COC(C)=O)C3=CSC(=N3)N",-2.384,7,2,8]
["S4521","DEET","f8","L3000-19","in 10mM DMSO","Anti-infection","Microbiology","DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.",191.27,"134-62-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/deet.html","C12H17NO","free base","N,N-Diethyl-meta-toluamide, diethyltoluamide","CCN(CC)C(=O)C1=CC(=CC=C1)C",2.427,1,0,3]
["S4524","2-Ethoxybenzamide","g8","L3000-19","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","2-Ethoxybenzamide (Ethenzamide) is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.",165.19,"938-73-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/2-ethoxybenzamide.html","C9H11NO2","Free Base","Ethenzamide","CCOC1=C(C=CC=C1)C(N)=O",1.164,2,1,3]
["S4526","Fenbufen","h8","L3000-19","in 10mM DMSO","COX","Neuronal Signaling","Fenbufen (Lederfen, CL-82204) is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.",254.28,"36330-85-5",{"v":50,"d":"50.00"},196.63,"<1","N/A","http://selleckchem.com/products/fenbufen.html","C16H14O3","free base","Lederfen, CL-82204","OC(=O)CCC(=O)C1=CC=C(C=C1)C2=CC=CC=C2",2.933,2,0,5]
["S4527","Fenofibric acid","a9","L3000-19","in 10mM DMSO","PPAR","Metabolism","Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.",318.75,"42017-89-0",{"v":63,"d":"63.00"},197.65,{"v":63,"d":"63.00"},197.65,"http://selleckchem.com/products/fenofibric-acid.html","C17H15ClO4","free base","NSC 281318, Trilipix, FNF acid","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C(O)=O",4.159,3,0,5]
["S4528","Furazolidone","b9","L3000-19","in 10mM DMSO","Bacterial","Microbiology","Furazolidone(Furoxone) is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.",225.16,"67-45-8",{"v":45,"d":"45.00"},199.86,"<1","N/A","http://selleckchem.com/products/furazolidone.html","C8H7N3O5","free base","Furoxone","[O-][N+](=O)C1=CC=C(O1)\\C=N\\N2CCOC2=O",{"v":1.1,"d":"1.100"},4,0,3]
["S4534","6-Acetamidohexanoic acid","c9","L3000-19","in 10mM DMSO","Others","Others","6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate.",173.21,"57-08-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/6-acetamidohexanoic-acid.html","C8H15NO3","Free Base","6-Acetamidocaproic acid","CC(=O)NCCCCCC(O)=O",0.337,2,1,6]
["S4535","Methylene Blue","d9","L3000-19","in 10mM DMSO","Dyes,Guanylate Cyclase,Microtubule Associated","GPCR & G Protein","Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.",319.85,"61-73-4",{"v":63,"d":"63.00"},196.97,{"v":63,"d":"63.00"},196.97,"http://selleckchem.com/products/methylene-blue.html","C16H18ClN3S","free base","Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015","[Cl-].CN(C)C1=CC2=C(C=C1)N=C3C=CC(C=C3S2)=[N+](C)C",0.369,1,0,1]
["S4538","Pantoprazole sodium","e9","L3000-19","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",405.35,"138786-67-1",{"v":81,"d":"81.00"},199.83,{"v":81,"d":"81.00"},199.83,"http://selleckchem.com/products/pantoprazole-sodium.html","C16H14F2N3NaO4S","Free Base","SKF96022 sodium, BY-1023 sodium","[Na+].COC1=CC=NC(=C1OC)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F",2.883,6,0,7]
["S4539","Salicylic acid","f9","L3000-19","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1","N/A","http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4541","Triclosan","g9","L3000-19","in 10mM DMSO","Bacterial","Microbiology","Triclosan (Irgasan, Cloxifenolum) is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.",289.54,"3380-34-5",{"v":57,"d":"57.00"},196.86,"<1","N/A","http://selleckchem.com/products/triclosan.html","C12H7Cl3O2","free base","Irgasan, Cloxifenolum","OC1=CC(=CC=C1OC2=CC=C(Cl)C=C2Cl)Cl",5.141,1,1,2]
["S4544","Urethane","h9","L3000-19","in 10mM DMSO","Bacterial","Microbiology","Urethane (Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane) is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis.",89.09,"51-79-6",{"v":17,"d":"17.00"},190.82,{"v":17,"d":"17.00"},190.82,"http://selleckchem.com/products/urethane.html","C3H7NO2","free base","Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane","CCOC(N)=O",0.159,2,1,2]
["S4546","Xylitol","a10","L3000-19","in 10mM DMSO","Autophagy","Autophagy","Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.",152.15,"87-99-0",{"v":30,"d":"30.00"},197.17,{"v":30,"d":"30.00"},197.17,"http://selleckchem.com/products/xylitol.html","C5H12O5","free base","Adonitol, Ribitol, Xylite, D-Xylitol, Adonite","OCC(O)C(O)C(O)CO",{"v":-2.43,"d":"-2.430"},0,5,4]
["S4547","8-Hydroxyquinoline","b10","L3000-19","in 10mM DMSO","Bacterial","Microbiology","8-Hydroxyquinoline (8-Oxychinolin, 8-Quinolinol, Oxine) is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes.",145.16,"148-24-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/8-hydroxyquinoline.html","C9H7NO","Free Base","8-Oxychinolin, 8-Quinolinol, Oxine","OC1=CC=CC2=CC=CN=C12",1.774,1,1,0]
["S4548","Aminoguanidine hydrochloride","c10","L3000-19","in 10mM DMSO","NOS","Immunology & Inflammation","Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.",110.55,"1937-19-5",{"v":22,"d":"22.00"},{"v":199,"d":"199.00"},{"v":22,"d":"22.00"},{"v":199,"d":"199.00"},"http://selleckchem.com/products/aminoguanidine-hydrochloride.html","CH6N4.HCl","hydrochloride","Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine","Cl.NNC(N)=N",-1.098,0,3,1]
["S4550","Azelaic acid","d10","L3000-19","in 10mM DMSO","Bacterial","Microbiology","Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.",188.22,"123-99-9",{"v":37,"d":"37.00"},196.58,{"v":37,"d":"37.00"},196.58,"http://selleckchem.com/products/azelaic-acid.html","C9H16O4","free base","Nonanedioic acid, Finacea, Azelex, Anchoic acid","OC(=O)CCCCCCCC(O)=O",1.921,2,0,8]
["S4552","Bithionol","e10","L3000-19","in 10mM DMSO","cAMP","GPCR & G Protein","Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.",356.05,"97-18-7",{"v":71,"d":"71.00"},199.41,"<1","N/A","http://selleckchem.com/products/bithionol.html","C12H6Cl4O2S","free base","Actamer","OC1=C(Cl)C=C(Cl)C=C1SC2=C(O)C(=CC(=C2)Cl)Cl",6.122,0,2,2]
["S4561","Danthron","f10","L3000-19","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.",240.21,"117-10-2",{"v":4,"d":"4.00"},16.65,"<1","N/A","http://selleckchem.com/products/danthron.html","C14H8O4","free base","chrysazin, Antrapurol","OC1=CC=CC2=C1C(=O)C3=C(O)C=CC=C3C2=O",2.324,2,2,0]
["S4564","Diethylcarbamazine citrate","g10","L3000-19","in 10mM DMSO","Parasite","Microbiology","Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements.",391.42,"1642-54-2",{"v":78,"d":"78.00"},199.27,{"v":78,"d":"78.00"},199.27,"http://selleckchem.com/products/diethylcarbamazine-citrate.html","C10H21N3O.C6H8O7","citrate","N/A","CCN(CC)C(=O)N1CCN(C)CC1.OC(=O)CC(O)(CC(O)=O)C(O)=O",-3.918,4,0,7]
["S4569","Fluphenazine dihydrochloride","h10","L3000-19","in 10mM DMSO","Dopamine Receptor","GPCR & G Protein","Fluphenazine dihydrochloride (Prolixin) is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits  Histamine H1 Receptor.",510.44,"146-56-5",{"v":100,"d":"100.00"},195.91,{"v":100,"d":"100.00"},195.91,"http://selleckchem.com/products/fluphenazine-dihydrochloride.html","C22H26F3N3OS.2HCl","dihydrochloride","Prolixin","Cl.Cl.OCCN1CCN(CCCN2C3=C(SC4=CC=C(C=C24)C(F)(F)F)C=CC=C3)CC1",5.199,0,1,7]
["S4570","Halothane","a11","L3000-19","in 10mM DMSO","Others","Others","Halothane (Narcotane) is a general inhalation anesthetic used for induction and maintenance of general anesthesia.",197.38,"151-67-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/halothane.html","C2HBrClF3","free base","Narcotane","FC(F)(F)C(Cl)Br",2.509,0,0,1]
["S4571","Hexylresorcinol","b11","L3000-19","in 10mM DMSO","Tyrosinase","Proteases","Hexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.",194.27,"136-77-6",{"v":38,"d":"38.00"},{"v":195.6,"d":"195.60"},"<1","N/A","http://selleckchem.com/products/hexylresorcinol.html","C12H18O2","free base","4-Hexylresorcinol","CCCCCCC1=C(O)C=C(O)C=C1",4.113,0,2,5]
["S4576","Sulfabenzamide","c11","L3000-19","in 10mM DMSO","Bacterial","Microbiology","Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.",276.31,"127-71-9",{"v":55,"d":"55.00"},199.05,"<1","N/A","http://selleckchem.com/products/sulfabenzamide.html","C13H12N2O3S","free base","Sultrin, N-Sulfanilylbenzamide","NC1=CC=C(C=C1)[S](=O)(=O)NC(=O)C2=CC=CC=C2",1.442,3,2,3]
["S4578","Tyloxapol","d11","L3000-19","in 10mM DMSO","Others","Others","Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.","N/A","25301-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/tyloxapol.html","(C14H22O.C2H4O.CH2O)x","free base","Triton WR1339","CC1=CC(=CC(=C1OCCO)CC2=C(OCCO)C(=CC(=C2)C(C)(C)CC(C)(C)C)CC3=C(OCCO)C=CC(=C3)C(C)(C)CC(C)(C)C)C(C)(C)CC(C)(C)C",{"v":16.58,"d":"16.580"},3,3,22]
["S4583","Butamben","e11","L3000-19","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.",193.24,"94-25-7",{"v":38,"d":"38.00"},196.65,{"v":38,"d":"38.00"},196.65,"http://selleckchem.com/products/butamben.html","C11H15NO2","free base","Butyl 4-aminobenzoate","CCCCOC(=O)C1=CC=C(N)C=C1",2.267,2,1,5]
["S4585","Succinylsulfathiazole","f11","L3000-19","in 10mM DMSO","Antibiotics","Microbiology","Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.",355.39,"116-43-8",{"v":71,"d":"71.00"},199.78,"<1","N/A","http://selleckchem.com/products/succinylsulfathiazole.html","C13H13N3O5S2","free base","Succinylsulphathiazole","OC(=O)CCC(=O)NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CS2",{"v":0.28,"d":"0.280"},5,2,7]
["S4587","Pentylenetetrazol","g11","L3000-19","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.",138.17,"54-95-5",{"v":27,"d":"27.00"},195.41,{"v":27,"d":"27.00"},195.41,"http://selleckchem.com/products/pentylenetetrazol.html","C6H10N4","Free Base","Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ","C1CC[N]2N=NN=C2CC1",0.568,3,0,0]
["S4589","Amodiaquine dihydrochloride dihydrate","h11","L3000-19","in 10mM DMSO","Histone Methyltransferase,HNMT,Transferase","Epigenetics","Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.",464.81,"6398-98-7",{"v":92,"d":"92.00"},197.93,{"v":29,"d":"29.00"},62.39,"http://selleckchem.com/products/amodiaquine-dihydrochloride-dihydrate.html","C20H22ClN3O.2HCl.2H2O","dihydrochloride dihydrate","N/A","O.O.Cl.Cl.CCN(CC)CC1=CC(=CC=C1O)NC2=C3C=CC(=CC3=NC=C2)Cl",5.109,1,2,6]
["S4591","Nitroxoline","a2","L3000-20","in 10mM DMSO","Cathepsin B,Cysteine Protease","Proteases","Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.",190.16,"4008-48-4",{"v":38,"d":"38.00"},199.83,"<1","N/A","http://selleckchem.com/products/nitroxoline.html","C9H6N2O3","free base","8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline","OC1=CC=C(C2=CC=CN=C12)[N+]([O-])=O",1.668,1,1,1]
["S4593","Chlormadinone acetate","b2","L3000-20","in 10mM DMSO","5-alpha Reductase,Androgen Receptor","Endocrinology & Hormones","Chlormadinone acetate (Gestafortin) is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours.",404.93,"302-22-7",{"v":27,"d":"27.00"},66.68,"<1","N/A","http://selleckchem.com/products/chlormadinone-acetate.html","C23H29ClO4","free base","Gestafortin","CC(=O)OC1(CCC2C3C=C(Cl)C4=CC(=O)CCC4(C)C3CCC12C)C(C)=O",3.428,4,0,3]
["S4594","Cephalothin sodium","c2","L3000-20","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Bacterial","Microbiology","Cephalothin (Cefalotin, Cephalotin) sodium is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall.",418.42,"58-71-9",{"v":10,"d":"10.00"},{"v":23.9,"d":"23.90"},{"v":83,"d":"83.00"},198.37,"http://selleckchem.com/products/cephalothin.html","C16H15N2NaO6S2","sodium","Cefalotin sodium, Sodium cephalotin","[Na+].CC(=O)OCC1=C(N2C(SC1)C(NC(=O)CC3=CC=CS3)C2=O)C([O-])=O",-1.067,4,1,7]
["S4595","Cefazolin Sodium","d2","L3000-20","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefazolin Sodium (cefazoline, cephazolin, Ancef) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.",476.49,"27164-46-1",{"v":95,"d":"95.00"},199.37,{"v":95,"d":"95.00"},199.37,"http://selleckchem.com/products/cefazolin-sodium.html","C14H14N8O4S3.Na","sodium","cefazoline sodium, cephazolin sodium, Ancef","[Na+].CC1=NN=C(SCC2=C(N3C(SC2)C(NC(=O)C[N]4C=NN=N4)C3=O)C([O-])=O)S1",-2.807,7,1,7]
["S4596","Cefixime","e2","L3000-20","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Cefixime (Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635) is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin.",453.45,"79350-37-1",{"v":90,"d":"90.00"},198.48,"<1","N/A","http://selleckchem.com/products/cefixime.html","C16H15N5O7S2","free base","Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635","NC1=NC(=CS1)C(=N/OCC(O)=O)/C(=O)NC2C3SCC(=C(N3C2=O)C(O)=O)C=C",-0.651,7,2,8]
["S4599","Benzyl benzoate","f2","L3000-20","in 10mM DMSO","Parasite","Microbiology","Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.",212.24,"120-51-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/benzyl-benzoate.html","C14H12O2","free base","Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester","O=C(OCC1=CC=CC=C1)C2=CC=CC=C2",3.268,2,0,4]
["S4600","Benzyl alcohol","g2","L3000-20","in 10mM DMSO","Others","Others","Benzyl alcohol (Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol) is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.",108.14,"100-51-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/benzyl-alcohol.html","C7H8O","free base","Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol","OCC1=CC=CC=C1",1.225,0,1,1]
["S4601","Clioquinol","h2","L3000-20","in 10mM DMSO","Fungal","Microbiology","Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.",{"v":305.5,"d":"305.50"},"130-26-7",{"v":61,"d":"61.00"},199.67,"<1","N/A","http://selleckchem.com/products/5-chloro-8-hydroxy-7-iodoquinoline.html","C9H5ClINO","free base","Iodochlorhydroxyquin, Chinoform","OC1=C(I)C=C(Cl)C2=CC=CN=C12",3.016,1,1,0]
["S4602","Acetohydroxamic acid","a3","L3000-20","in 10mM DMSO","Bacterial","Microbiology","Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat,AHA) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.",75.07,"546-88-3",{"v":15,"d":"15.00"},199.81,{"v":15,"d":"15.00"},199.81,"http://selleckchem.com/products/acetohydroxamic-acid.html","C2H5NO2","free base","N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat,AHA","CC(=O)NO",{"v":-0.82,"d":"-0.820"},1,1,0]
["S4603","Gallic acid","b3","L3000-20","in 10mM DMSO","ROS","Immunology & Inflammation","Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.",170.12,"149-91-7",{"v":34,"d":"34.00"},199.86,{"v":7,"d":"7.00"},41.15,"http://selleckchem.com/products/gallic-acid.html","C7H6O5","free base","3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid","OC(=O)C1=CC(=C(O)C(=C1)O)O",0.733,1,3,1]
["S4604","Levofloxacin hydrate","c3","L3000-20","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Levofloxacin (Levaquin, Tavanic, Quixin, Iquix, Cravit) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).",370.38,"138199-71-0",{"v":74,"d":"74.00"},199.79,{"v":5,"d":"5.00"},{"v":13.5,"d":"13.50"},"http://selleckchem.com/products/levofloxacin-hydrate.html","C18H20FN3O4.1/2H2O","hydrate","Levofloxacin hemihydrate, Levaquin hydrate, Tavanic hydrate, Quixin hydrate, Iquix hydrate, Cravit hydrate","CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCN(C)CC4)F",{"v":-0.64,"d":"-0.640"},3,0,2]
["S4609","Diflunisal","d3","L3000-20","in 10mM DMSO","COX","Neuronal Signaling","Diflunisal (Dolobid, Dolobis, Flovacil, Fluniget,MK-647) is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.",{"v":250.2,"d":"250.20"},"22494-42-4",{"v":50,"d":"50.00"},199.84,"<1","N/A","http://selleckchem.com/products/diflunisal.html","C13H8F2O3","free base","Dolobid, Dolobis, Flovacil, Fluniget,MK-647","OC(=O)C1=C(O)C=CC(=C1)C2=C(F)C=C(F)C=C2",3.147,1,1,2]
["S4610","Mebendazole","e3","L3000-20","in 10mM DMSO","Parasite","Microbiology","Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.",295.29,"31431-39-7",{"v":6,"d":"6.00"},20.32,"<1","N/A","http://selleckchem.com/products/mebendazole.html","C16H13N3O3","free base","Vermox, Telmin, Pantelmin, Mebenvet","COC(=O)NC1=NC2=C([NH]1)C=CC(=C2)C(=O)C3=CC=CC=C3",3.055,4,2,4]
["S4619","Itopride hydrochloride","f3","L3000-20","in 10mM DMSO","AChR","Neuronal Signaling","Itopride hydrochloride (Ganaton, HSR803) is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.",394.89,"122892-31-3",{"v":78,"d":"78.00"},197.52,{"v":78,"d":"78.00"},197.52,"http://selleckchem.com/products/itopride-hydrochloride.html","C20H26N2O4.HCl","hydrochloride","Ganaton, HSR803","Cl.COC1=CC=C(C=C1OC)C(=O)NCC2=CC=C(OCCN(C)C)C=C2",3.093,4,1,9]
["S4625","Alcaftadine","g3","L3000-20","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Alcaftadine (Lastacaft, R89674) is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.",307.39,"147084-10-4",{"v":28,"d":"28.00"},91.09,"<1","N/A","http://selleckchem.com/products/alcaftadine.html","C19H21N3O","free base","Lastacaft, R89674","CN1CCC(CC1)=C2C3=C(CC[N]4C(=CN=C24)C=O)C=CC=C3",2.831,2,0,1]
["S4627","TTNPB (Arotinoid Acid)","h3","L3000-20","in 10mM DMSO","Retinoid Receptor","Metabolism","TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.",348.48,"71441-28-6",{"v":15,"d":"15.00"},43.04,"<1","N/A","http://selleckchem.com/products/ttnpb-arotinoid-acid.html","C24H28O2","free base","Ro 13-7410, AGN-191183","CC(=C\\C1=CC=C(C=C1)C(O)=O)/C2=CC3=C(C=C2)C(C)(C)CCC3(C)C",6.321,1,0,3]
["S4628","(+/-)-Sulfinpyrazone","a4","L3000-20","in 10mM DMSO","COX","Neuronal Signaling","Sulfinpyrazone (G-28315, NSC 75925) is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.",404.48,"57-96-5",{"v":80,"d":"80.00"},197.78,"<1","N/A","http://selleckchem.com/products/sulfinpyrazone.html","C23H20N2O3S","free base","G-28315, NSC 75925","O=C1C(CC[S](=O)C2=CC=CC=C2)C(=O)N(N1C3=CC=CC=C3)C4=CC=CC=C4",3.434,3,0,6]
["S4629","Chlorotrianisene","b4","L3000-20","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Chlorotrianisene (tri-p-anisylchloroethylene, TACE, CTA) is a synthetic, non-steroidal estrogen. It is a selective estrogen receptor modulator.",380.86,"569-57-3",{"v":76,"d":"76.00"},199.55,"<1","N/A","http://selleckchem.com/products/chlorotrianisene.html","C23H21ClO3","free base","tri-p-anisylchloroethylene, tris(p-methoxyphenyl)chloroethylene, TACE, CTA","COC1=CC=C(C=C1)C(Cl)=C(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3",5.614,3,0,6]
["S4630","Diazoxide","c4","L3000-20","in 10mM DMSO","ADC Cytotoxin,Potassium Channel","Transmembrane Transporters","Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.",230.67,"364-98-7",{"v":46,"d":"46.00"},199.42,"<1","N/A","http://selleckchem.com/products/diazoxide.html","C8H7ClN2O2S","free base","Sch-6783, SRG-95213, Proglycem","CC1=NC2=CC=C(Cl)C=C2[S](=O)(=O)N1",1.196,3,1,0]
["S4633","Isosorbide Mononitrate","d4","L3000-20","in 10mM DMSO","Others","Others","Isosorbide mononitrate (Elantan, Monoket, Mononit, Imdur, Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.",191.14,"16051-77-7",{"v":38,"d":"38.00"},198.81,{"v":38,"d":"38.00"},198.81,"http://selleckchem.com/products/isosorbide-mononitrate.html","C6H9NO6","Free Base","Isosorbide-5-mononitrate, Elantan, Monoket, Mononit, Imdur, Corangin","OC1COC2C(COC12)O[N+]([O-])=O",1.003,3,1,2]
["S4635","Cyproheptadine hydrochloride sesquihydrate","e4","L3000-20","in 10mM DMSO","5-HT Receptor,SETD","Neuronal Signaling","Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.",350.88,"41354-29-4",{"v":70,"d":"70.00"},{"v":199.5,"d":"199.50"},"<1","N/A","https://www.selleckchem.com/products/cyproheptadine-hydrochloride-sesquihydrate.html","C21H21N.HCl.3/2H2O","hydrochloride sesquihydrate","Periactin hydrochloride, Peritol","O.O.O.Cl.Cl.CN1CCC(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C24.CN5CCC(CC5)=C6C7=CC=CC=C7C=CC8=CC=CC=C68",5.478,0,0,0]
["S4641","Tedizolid Phosphate","f4","L3000-20","in 10mM DMSO","Antibiotics","Microbiology","Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.",450.32,"856867-55-5",{"v":22,"d":"22.00"},48.85,"<1","N/A","http://selleckchem.com/products/tedizolid-phosphate.html","C17H16FN6O6P","free base","TR-701FA","C[N]1N=NC(=N1)C2=NC=C(C=C2)C3=CC=C(C=C3F)N4CC(CO[P](O)(O)=O)OC4=O",1.712,7,0,6]
["S4646","Ciclesonide","g4","L3000-20","in 10mM DMSO","COVID-19,Glucocorticoid Receptor","Endocrinology & Hormones","Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.",540.69,"126544-47-6",{"v":100,"d":"100.00"},184.95,"<1","N/A","http://selleckchem.com/products/ciclesonide.html","C32H44O7","free base","Alvesco, Omnaris, RPR251526, Zetonna","CC(C)C(=O)OCC(=O)C12OC(OC1CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC23C)C6CCCCC6",4.696,6,1,6]
["S4647","Cefmenoxime hydrochloride","h4","L3000-20","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly.",1059.58,"75738-58-8",{"v":70,"d":"70.00"},66.06,"<1","N/A","http://selleckchem.com/products/cefmenoxime-hydrochloride.html","C32H34N18O10S6.HCl","hydrochloride","Cefmenoxime hemihydrochloride, SCE-1365 hemihydrochloride","Cl.CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)CSC3=NN=N[N]3C)C4=CSC(=N4)N.CO\\N=C(/C(=O)NC5C6SCC(=C(N6C5=O)C(O)=O)CSC7=NN=N[N]7C)C8=CSC(=N8)N",-1.031,18,4,16]
["S4650","Atipamezole","a5","L3000-20","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.",212.29,"104054-27-5",{"v":42,"d":"42.00"},197.84,"<1","N/A","http://selleckchem.com/products/atipamezole.html","C14H16N2","Free Base","MPV-1248, MPV1248, MPV 1248, Antisedan","CCC1(CC2=C(C1)C=CC=C2)C3=CN=C[NH]3",3.012,1,1,2]
["S4651","Etoricoxib","b5","L3000-20","in 10mM DMSO","COX","Neuronal Signaling","Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.",358.84,"202409-33-4",{"v":71,"d":"71.00"},197.86,"<1","N/A","http://selleckchem.com/products/etoricoxib.html","C18H15ClN2O2S","free base","Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia","CC1=NC=C(C=C1)C2=NC=C(Cl)C=C2C3=CC=C(C=C3)[S](C)(=O)=O",3.467,4,0,3]
["S4656","Parecoxib","c5","L3000-20","in 10mM DMSO","COX","Neuronal Signaling","Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.",370.42,"198470-84-7",{"v":74,"d":"74.00"},199.77,"<1","N/A","http://selleckchem.com/products/parecoxib.html","C19H18N2O4S","free base","SC-69124, Valus-P, Vorth-P","CCC(=O)N[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",3.256,5,1,5]
["S4658","Hydroquinidine","d5","L3000-20","in 10mM DMSO","Others","Others","Hydroquinidine (Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine) is an antiarrhythmic agent.",326.43,"1435-55-8",{"v":65,"d":"65.00"},199.12,"<1","N/A","http://selleckchem.com/products/hydroquinidine.html","C20H26N2O2","free base","Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4660","Glycopyrrolate","e5","L3000-20","in 10mM DMSO","AChR","Neuronal Signaling","Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.",398.33,"596-51-0",{"v":65,"d":"65.00"},163.18,{"v":79,"d":"79.00"},198.33,"http://selleckchem.com/products/glycopyrrolate.html","C19H28NO3.Br","bromide","Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn","[Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)C3=CC=CC=C3",-0.961,2,0,5]
["S4662","Atazanavir","f5","L3000-20","in 10mM DMSO","HIV Protease,P450 (e.g. CYP17),P-gp","Proteases","Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.",704.86,"198904-31-3",{"v":71,"d":"71.00"},100.73,"<1","N/A","http://selleckchem.com/products/atazanavir-reyataz.html","C38H52N6O7","free base","Latazanavir, Zrivada, Reyataz, BMS-232632","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C",{"v":4.69,"d":"4.690"},7,5,18]
["S4665","Rabeprazole sodium","g5","L3000-20","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an antiulcer drug in the class of proton pump inhibitors.",381.42,"117976-90-6",{"v":76,"d":"76.00"},199.26,{"v":76,"d":"76.00"},199.26,"https://www.selleckchem.com/products/rabeprazole-sodium.html","C18H20N3O3S.Na","sodium salt","Aciphex Sodium, Dexrabeprazole Sodium, Habeprazole Sodium","COCCCOC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=CC=CC=C3[N]2[Na]",{"v":2.47,"d":"2.470"},5,0,8]
["S4666","Sivelestat sodium tetrahydrate","h5","L3000-20","in 10mM DMSO","Serine Protease","Proteases","Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.",528.51,"201677-61-4",{"v":100,"d":"100.00"},189.21,"<1","N/A","http://selleckchem.com/products/sivelestat-sodium.html","C20H21N2O7S.4H2O.Na","sodium salt","Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium","O.O.O.O.[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC([O-])=O",0.018,5,2,9]
["S4667","Lidocaine hydrochloride","a6","L3000-20","in 10mM DMSO","EGFR","Angiogenesis","Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.",{"v":270.8,"d":"270.80"},"73-78-9",{"v":54,"d":"54.00"},199.41,{"v":54,"d":"54.00"},199.41,"http://selleckchem.com/products/lidocaine-hydrochloride.html","C14H22N2O.HCl","hydrochloride","Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural","Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",3.008,1,1,5]
["S4669","Benzocaine hydrochloride","b6","L3000-20","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.",201.65,"23239-88-5",{"v":40,"d":"40.00"},198.36,"<1","N/A","http://selleckchem.com/products/benzocaine-hydrochloride.html","C9H11NO2.HCl","hydrochloride","Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride","Cl.CCOC(=O)C1=CC=C(N)C=C1",1.669,2,1,3]
["S4672","Dimenhydrinate","c6","L3000-20","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Dimenhydrinate is an over-the-counter drug used to prevent nausea, vomiting, and dizziness caused by motion sickness.",469.96,"523-87-5",{"v":94,"d":"94.00"},200.02,"<1","N/A","http://www.selleck.cn/products/dimenhydrinate.html","C24H28ClN5O3","Free Base","N/A","CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.CN3C(=O)N(C)C4=C([NH]C(=N4)Cl)C3=O",3.955,4,1,6]
["S4673","Etonogestrel","d6","L3000-20","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Etonogestrel (Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel) is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.",324.46,"54048-10-1",{"v":64,"d":"64.00"},197.25,"<1","N/A","http://selleckchem.com/products/etonogestrel.html","C22H28O2","free base","Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel","CCC12CC(=C)C3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.827,1,0,1]
["S4679","Terazosin HCl","e6","L3000-20","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.",423.89,"63074-08-8",{"v":84,"d":"84.00"},198.16,{"v":1,"d":"1.00"},2.36,"http://selleckchem.com/products/terazosin.html","C19H25N5O4.HCl","hydrochloride","Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin","Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N",1.762,6,1,4]
["S4682","Loxoprofen","f6","L3000-20","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.",{"v":246.3,"d":"246.30"},"68767-14-6",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/loxoprofen.html","C15H18O3","free base","Koloxo, Loxoprofene, Loxoprofeno","CC(C(O)=O)C1=CC=C(CC2CCCC2=O)C=C1",2.936,2,0,4]
["S4685","Efavirenz","g6","L3000-20","in 10mM DMSO","Reverse Transcriptase","Microbiology","Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.",315.67,"154598-52-4",{"v":63,"d":"63.00"},199.58,"<1","N/A","http://selleckchem.com/products/efavirenz.html","C14H9ClF3NO2","free base","Sustiva, Stocrin, DMP-266, DMP 266","FC(F)(F)C1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC3CC3",4.381,2,1,3]
["S4686","Vitamin E","h6","L3000-20","in 10mM DMSO","COX,VEGFR","Neuronal Signaling","Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.",430.71,"59-02-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e.html","C29H50O2","free base","Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S4687","Rivastigmine","a7","L3000-20","in 10mM DMSO","AChR","Neuronal Signaling","Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).",250.34,"123441-03-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/rivastigmine.html","C14H22N2O2","free base","SDZ-ENA 713, Exelon","CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C",2.599,2,0,5]
["S4690","Escin","b7","L3000-20","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Escin (Aescin) is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).",1131.26,"6805-41-0",{"v":66,"d":"66.00"},58.34,"<1","N/A","http://selleckchem.com/products/escin.html","C55H86O24","free base","Aescin","C\\C=C(C)/C(=O)OC1C(OC(C)=O)C2(CO)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(OC7OC(CO)C(O)C(O)C7O)C(O)C6OC8OC(CO)C(O)C(O)C8O)C(O)=O)C(C)(CO)C5CCC34C)C2CC1(C)C",-0.723,11,12,16]
["S4693","Guanfacine Hydrochloride","c7","L3000-20","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.",282.55,"29110-48-3",{"v":56,"d":"56.00"},{"v":198.2,"d":"198.20"},{"v":30,"d":"30.00"},106.18,"http://selleckchem.com/products/guanfacine-hydrochloride.html","C9H9Cl2N3O.HCl","hydrochloride","Guanfacine, Tenex, Intuniv","Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl",2.412,1,2,3]
["S4695","D panthenol","d7","L3000-20","in 10mM DMSO","Vitamin","Metabolism","D panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent.",205.25,"81-13-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/d-panthenol.html","C9H19NO4","free base","Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol","CC(C)(CO)C(O)C(=O)NCCCO",-1.266,1,4,6]
["S4696","CarbinoxaMine Maleate","e7","L3000-20","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Carbinoxamine maleate is a histamine-H1 receptor blocking agent with antihistamine and anticholinergic properties.",406.86,"3505-38-2",{"v":81,"d":"81.00"},199.09,{"v":81,"d":"81.00"},199.09,"http://selleckchem.com/products/carbinoxamine-maleate.html","C16H19ClN2O.C4H4O4","maleate","N/A","CN(C)CCOC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",0.224,4,0,8]
["S4697","Saxagliptin hydrate","f7","L3000-20","in 10mM DMSO","DPP","Proteases","Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",333.43,"945667-22-1",{"v":66,"d":"66.00"},197.94,{"v":1,"d":"1.00"},{"v":3,"d":"3.00"},"http://selleckchem.com/products/saxagliptin-hydrate.html","C18H25N3O2.H2O","hydrate","BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate","O.NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.068,1,1,2]
["S4701","2-Deoxy-D-glucose (2-DG)","g7","L3000-20","in 10mM DMSO","Apoptosis related,Carbohydrate Metabolism,HSV","Metabolism","2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.",164.16,"154-17-6",{"v":32,"d":"32.00"},194.93,{"v":32,"d":"32.00"},194.93,"http://selleckchem.com/products/2-deoxy-d-glucose.html","C6H12O5","free base","2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose","OCC1OC(O)CC(O)C1O",-1.748,1,3,1]
["S4706","Eugenol","h7","L3000-20","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.",{"v":164.2,"d":"164.20"},"97-53-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/eugenol.html","C10H12O2","Free Base","4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol","COC1=C(O)C=CC(=C1)CC=C",2.579,1,1,3]
["S4707","Oleic Acid","a8","L3000-20","in 10mM DMSO","ATPase","Transmembrane Transporters","Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent.  Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.",282.46,"112-80-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/oleic-acid.html","C18H34O2","Free Base","Oleate, 9-Octadecenoic Acid, Elaidoic acid","CCCCCCCC\\C=C/CCCCCCCC(O)=O",{"v":6.86,"d":"6.860"},1,0,15]
["S4708","Palmitoylethanolamide","b8","L3000-20","in 10mM DMSO","PPAR","Metabolism","Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.",299.49,"544-31-0",{"v":59,"d":"59.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/palmitoylethanolamide.html","C18H37NO2","free base","Palmidrol|N-palmitoylethanolamine","CCCCCCCCCCCCCCCC(=O)NCCO",5.431,1,2,16]
["S4709","Latanoprost","c8","L3000-20","in 10mM DMSO","GPR,Immunology & Inflammation related,RAR/RXR","Immunology & Inflammation","Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.",432.59,"130209-82-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/latanoprost.html","C26H40O5","Free Base","Xalatan, PhXA41, PHXA-41","CC(C)OC(=O)CCC\\C=C/CC1C(O)CC(O)C1CCC(O)CCC2=CC=CC=C2",4.365,2,3,14]
["S4711","Esculetin","d8","L3000-20","in 10mM DMSO","Lipoxygenase","Metabolism","Esculetin (Cichorigenin, Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).",178.14,"305-01-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/esculetin.html","C9H6O4","free base","Cichorigenin, Aesculetin","OC1=CC2=C(C=CC(=O)O2)C=C1O",1.415,2,2,0]
["S4712","Diethylmaleate","e8","L3000-20","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Diethylmaleate (Diethyl ester, Maleic acid diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.",172.18,"141-05-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/diethylmaleate.html","C8H12O4","Free Base","Diethyl ester, Maleic acid diethyl ester","CCOC(=O)\\C=C/C(=O)OCC",1.187,4,0,6]
["S4714","(-)-Menthol","f8","L3000-20","in 10mM DMSO","TRP Channel","Transmembrane Transporters","(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.",156.27,"2216-51-5",{"v":31,"d":"31.00"},198.37,{"v":16,"d":"16.00"},102.39,"http://selleckchem.com/products/-menthol.html","C10H20O","free base","L-Menthol, Levomenthol, Menthomenthol, Menthacamphor","CC(C)C1CCC(C)CC1O",2.779,0,1,1]
["S4715","Benzamide","g8","L3000-20","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Benzamide, a derivative of benzoic acid, is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.",121.14,"55-21-0",{"v":24,"d":"24.00"},198.12,"<1","N/A","http://selleckchem.com/products/benzamide.html","C7H7NO","free base","N/A","NC(=O)C1=CC=CC=C1",0.832,1,1,1]
["S4717","Isatin","h8","L3000-20","in 10mM DMSO","MAO","Metabolism","Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A.",147.13,"91-56-5",{"v":29,"d":"29.00"},{"v":197.1,"d":"197.10"},"<1","N/A","http://selleckchem.com/products/isatin.html","C8H5NO2","free base","2,3-Indolinedione","O=C1NC2=C(C=CC=C2)C1=O",{"v":0.67,"d":"0.670"},2,1,0]
["S4718","Acetylcholine iodide","a9","L3000-20","in 10mM DMSO","AChR","Neuronal Signaling","Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.",273.11,"2260-50-6",{"v":54,"d":"54.00"},197.72,{"v":54,"d":"54.00"},197.72,"http://selleckchem.com/products/acetylcholine-iodide.html","C7H16NO2.I","iodide salt","Acetylcolina","[I-].CC(=O)OCC[N+](C)(C)C",-4.308,2,0,4]
["S4719","Kynurenic acid","b9","L3000-20","in 10mM DMSO","NMDAR","Neuronal Signaling","Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA\n\nreceptors.",189.17,"492-27-3",{"v":10,"d":"10.00"},52.86,"<1","N/A","http://selleckchem.com/products/kynurenic-acid.html","C10H7NO3","free base","Quinurenic acid, Kynurenate","OC(=O)C1=CC(=C2C=CC=CC2=N1)O",1.832,2,1,1]
["S4722","(+)-Catechin","c9","L3000-20","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,",290.27,"154-23-4",{"v":58,"d":"58.00"},199.81,{"v":58,"d":"58.00"},199.81,"http://selleckchem.com/products/catechin.html","C15H14O6","free base","Cianidanol, Catechinic acid, Catechuic acid, Catechin","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4723","(-)Epicatechin","d9","L3000-20","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(−)Epicatechin (L-Epicatechin, (-)-Epicatechol) is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.",290.27,"490-46-0",{"v":58,"d":"58.00"},199.81,"<1","N/A","http://selleckchem.com/products/-epicatechin.html","C15H14O6","free base","L-Epicatechin, (-)-Epicatechol","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4725","Benzenesulfonamide","e9","L3000-20","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.",157.19,"98-10-2",{"v":31,"d":"31.00"},197.21,"<1","N/A","http://selleckchem.com/products/benzenesulfonamide.html","C6H7NO2S","free base","Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide","N[S](=O)(=O)C1=CC=CC=C1",0.535,2,1,1]
["S4727","Cinnarizine","f9","L3000-20","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.",368.51,"298-57-7",{"v":73,"d":"73.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/cinnarizine.html","C26H28N2","free base","Stugeron, Dimitronal, Stutgin, Cinarizine","C1CN(CCN1C\\C=C\\C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4",5.524,0,0,6]
["S4728","3,3'-Diindolylmethane","g9","L3000-20","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.",246.31,"1968-05-4",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/3-3-diindolylmethane.html","C17H14N2","free base","DIM","C(C1=C[NH]C2=C1C=CC=C2)C3=C[NH]C4=C3C=CC=C4",4.391,0,2,2]
["S4731","Perphenazine","h9","L3000-20","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.",403.97,"58-39-9",{"v":74,"d":"74.00"},183.18,"<1","N/A","http://selleckchem.com/products/perphenazine.html","C21H26ClN3OS","free base","Perphenazin, Trilafon, Etaperazine","OCCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4)CC1",4.157,0,1,6]
["S4732","MPTP hydrochloride","a10","L3000-20","in 10mM DMSO","Apoptosis related,Dopamine Receptor","Neuronal Signaling","MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.",209.72,"23007-85-4",{"v":20,"d":"20.00"},95.37,{"v":41,"d":"41.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/mptp-hydrochloride.html","C12H15N.HCl","hydrochloride","N/A","Cl.CN1CCC(=CC1)C2=CC=CC=C2",2.788,0,0,1]
["S4735","Salvianolic acid B","b10","L3000-20","in 10mM DMSO","Sirtuin","Epigenetics","Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.",718.61,"121521-90-2",{"v":100,"d":"100.00"},139.16,{"v":100,"d":"100.00"},139.16,"http://selleckchem.com/products/salvianolic-acid-b.html","C36H30O16","free base","Sal B, Lithospermate B, Lithospermic acid B","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=CC=C(O)C3=C2C(C(O3)C4=CC=C(O)C(=C4)O)C(=O)OC(CC5=CC=C(O)C(=C5)O)C(O)=O",4.718,7,7,14]
["S4736","Trapidil","c10","L3000-20","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Trapidil (Rocornal, Trapymin, Avantrin, Trapymine) is a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells.",205.26,"15421-84-8",{"v":41,"d":"41.00"},199.75,{"v":41,"d":"41.00"},199.75,"http://selleckchem.com/products/trapidil.html","C10H15N5","free base","Rocornal, Trapymin, Avantrin, Trapymine","CCN(CC)C1=CC(=NC2=NC=N[N]12)C",1.922,3,0,3]
["S4737","Psoralen","d10","L3000-20","in 10mM DMSO","ADC Cytotoxin,DNA/RNA Synthesis","DNA Damage/DNA Repair","Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.",186.16,"66-97-7",{"v":37,"d":"37.00"},198.75,"<1","N/A","http://selleckchem.com/products/psoralen.html","C11H6O3","free base","Psoralene, Ficusin, Furocoumarin","O=C1OC2=C(C=C1)C=C3C=COC3=C2",2.203,3,0,0]
["S4738","Arctiin","e10","L3000-20","in 10mM DMSO","AdipoR","Metabolism","Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.",534.55,"20362-31-6",{"v":100,"d":"100.00"},187.07,{"v":40,"d":"40.00"},74.83,"http://selleckchem.com/products/arctiin.html","C27H34O11","free base","Arctigenin-4-Glucoside, NSC 315527","COC1=CC=C(CC2COC(=O)C2CC3=CC=C(OC4OC(CO)C(O)C(O)C4O)C(=C3)OC)C=C1OC",1.814,7,4,10]
["S4743","Wogonin","f10","L3000-20","in 10mM DMSO","CDK,Transferase","Cell Cycle","Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.",284.26,"632-85-9",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/wogonin.html","C16H12O5","free base","Vogonin","COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C3=CC=CC=C3",2.636,3,2,2]
["S4744","Anethole trithione","g10","L3000-20","in 10mM DMSO","Others","Others","Anethole trithione is a drug used in the treatment of dry mouth.",240.36,"532-11-6",{"v":48,"d":"48.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://www.selleck.cn/products/anethole-trithione.html","C10H8OS3","Free Base","N/A","COC1=CC=C(C=C1)C2=CC(=S)SS2",3.635,1,0,2]
["S4746","(20S)-Protopanaxadiol","h10","L3000-20","in 10mM DMSO","P-gp","Transmembrane Transporters","20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.",460.73,"30636-90-9",{"v":92,"d":"92.00"},199.68,"<1","N/A","http://selleckchem.com/products/20s-protopanaxadiol.html","C30H52O3","free base","20-Epiprotopanaxadiol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4CCC23C",5.789,0,2,4]
["S4747","Jervine","a11","L3000-20","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Jervine (11-Ketocyclopamine) is a Hedgehog signaling (IC50=500-700 nM) inhibitor that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.",{"v":425.6,"d":"425.60"},"469-59-0",{"v":5,"d":"5.00"},11.75,"<1","N/A","http://selleckchem.com/products/jervine.html","C27H39NO3","free base","11-Ketocyclopamine","CC1CNC2C(C)C3(CCC4C5CC=C6CC(O)CCC6(C)C5C(=O)C4=C3C)OC2C1",3.472,2,2,0]
["S4748","Ondansetron Hydrochloride Dihydrate","b11","L3000-20","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors.",365.85,"103639-04-9",{"v":73,"d":"73.00"},199.54,{"v":73,"d":"73.00"},199.54,"http://selleckchem.com/products/ondansetron-hcl.html","C18H19N3O.HCl.2H2O","hydrochloride","N/A","O.O.Cl.C[N]1C2=C(C(=O)C(CC2)C[N]3C=CN=C3C)C4=C1C=CC=C4",2.602,2,0,2]
["S4749","Citalopram HBr","c11","L3000-20","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.",{"v":405.3,"d":"405.30"},"59729-32-7",{"v":81,"d":"81.00"},199.85,{"v":81,"d":"81.00"},199.85,"http://selleckchem.com/products/citalopram-hbr.html","C20H21FN2O.HBr","hydrobromide","Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr","Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C3=CC=C(F)C=C3",4.212,1,0,5]
["S4750","Sulfacetamide sodium salt hydrate","d11","L3000-20","in 10mM DMSO","Antibiotics,Autophagy,Bacterial","Autophagy","Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.",254.24,"6209-17-2",{"v":50,"d":"50.00"},196.66,{"v":50,"d":"50.00"},196.66,"http://selleckchem.com/products/sulfacetamide-sodium-salt-hydrate.html","C8H9N2O3S.H2O.Na","sodium salt hyd","N/A","O.CC(=O)N([Na])[S](=O)(=O)C1=CC=C(N)C=C1",-0.326,3,1,2]
["S4751","Cisapride hydrate","e11","L3000-20","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.",483.96,"260779-88-2",{"v":96,"d":"96.00"},198.36,"<1","N/A","https://www.selleckchem.com/products/cisapride-hydrate.html","C23H29ClFN3O4.H2O","hydrate","Propulsid, Alimix, Propulsin, Enteropride, Kinestase","O.COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C3=CC(=C(N)C=C3OC)Cl",2.578,4,2,9]
["S4753","Ganoderic acid A","f11","L3000-20","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.",516.67,"81907-62-2",{"v":100,"d":"100.00"},193.55,"<1","N/A","http://selleckchem.com/products/ganoderic-acid-a.html","C30H44O7","free base","N/A","CC(CC(=O)CC(C)C(O)=O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C4(C)CCC(=O)C(C)(C)C4CC3O",2.775,4,2,6]
["S4754","Betulin","g11","L3000-20","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.",442.72,"473-98-3",{"v":22,"d":"22.00"},49.69,"<1","N/A","http://selleckchem.com/products/betulin.html","C30H50O2","free base","betulinol, betuline, betulinic alcohol","CC(=C)C1CCC2(CO)CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12",6.312,0,2,2]
["S4758","Crocin","h11","L3000-20","in 10mM DMSO","Apoptosis related","Apoptosis","Crocin (Alpha-Crocin, Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L.). It has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer.",976.96,"42553-65-1",{"v":100,"d":"100.00"},102.36,"<1","N/A","http://selleckchem.com/products/crocin.html","C44H64O24","free base","Alpha-Crocin, Gardenia Yellow","CC(=C\\C=C\\C=C(C)\\C=C\\C=C(C)\\C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)\\C=C\\C=C(C)/C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O",-2.722,10,14,20]
["S4759","p-Coumaric Acid","a2","L3000-21","in 10mM DMSO","Anti-infection","Microbiology","p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.",164.16,"501-98-4",{"v":32,"d":"32.00"},194.93,"<1","N/A","http://selleckchem.com/products/p-coumaric-acid.html","C9H8O3","free base","4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid","OC(=O)\\C=C\\C1=CC=C(O)C=C1",1.685,1,1,2]
["S4761","Thymoquinone","b2","L3000-21","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects.",{"v":164.2,"d":"164.20"},"490-91-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/thymoquinone.html","C10H12O2","free base","N/A","CC(C)C1=CC(=O)C(=CC1=O)C",2.288,2,0,1]
["S4769","L-5-Hydroxytryptophan","c2","L3000-21","in 10mM DMSO","Others","Others","5-Hydroxytryptophan (5-HTP, L-oxitriptan), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.",220.22,"4350-09-8",{"v":16,"d":"16.00"},72.65,"N/A","N/A","http://selleckchem.com/products/l-5-hydroxytryptophan.html","C11H12N2O3","free base","L-oxitriptan","NC(CC1=C[NH]C2=CC=C(O)C=C12)C(O)=O",-1.554,1,3,3]
["S4771","β-thujaplicin","d2","L3000-21","in 10mM DMSO","DNA Methyltransferase","Epigenetics","β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods.  Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.",{"v":164.2,"d":"164.20"},"499-44-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/beta-thujaplicin.html","C10H12O2","free base","Hinokitiol, 4-Isopropyltropolone","CC(C)C1=CC=CC(=O)C(=C1)O",1.896,1,1,1]
["S4772","alpha-Asarone","e2","L3000-21","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.",208.25,"2883-98-9",{"v":41,"d":"41.00"},196.88,"N/A","N/A","http://selleckchem.com/products/alpha-asarone.html","C12H16O3","free base","trans-Asarone","COC1=CC(=C(\\C=C\\C)C=C1OC)OC",2.734,3,0,4]
["S4777","Plumbagin","f2","L3000-21","in 10mM DMSO","Apoptosis related","Apoptosis","Plumbagin (Plumbagine, Plumbaein, Plumbagone), a quinoid constituent isolated from the root of the medicinal plant Plumbago zeylanica L, exerts anticancer and antiproliferative activities in animal models and in cell culture.",188.18,"481-42-5",{"v":37,"d":"37.00"},196.62,"N/A","N/A","http://selleckchem.com/products/plumbagin.html","C11H8O3","free base","Plumbagine, Plumbaein, Plumbagone","CC1=CC(=O)C2=C(C=CC=C2O)C1=O",1.962,2,1,0]
["S4779","Menadiol Diacetate","g2","L3000-21","in 10mM DMSO","Vitamin","Microbiology","Menadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation.",258.27,"573-20-6",{"v":51,"d":"51.00"},197.47,"N/A","N/A","http://selleckchem.com/products/menadiol-diacetate.html","C15H14O4","free base","Vitamin K4, Acetomenaphthone, Kapilin","CC(=O)OC1=C2C=CC=CC2=C(OC(C)=O)C(=C1)C",2.759,4,0,4]
["S4781","Xanthoxyline","h2","L3000-21","in 10mM DMSO","Fungal","Microbiology","Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin.",{"v":196.2,"d":"196.20"},"90-24-4",{"v":39,"d":"39.00"},198.78,"N/A","N/A","http://selleckchem.com/products/xanthoxyline.html","C10H12O4","free base","Brevifolin","COC1=CC(=C(C(C)=O)C(=C1)OC)O",1.295,3,1,3]
["S4783","Benzyl isothiocyanate","a3","L3000-21","in 10mM DMSO","Antibiotics","Microbiology","Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.",149.21,"622-78-6",{"v":29,"d":"29.00"},194.36,"N/A","N/A","http://selleckchem.com/products/benzyl-isothiocyanate.html","C8H7NS","free base","Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester","S=C=NCC1=CC=CC=C1",{"v":0,"d":"0.000"},0,0,0]
["S4785","Nicotinamide N-oxide","b3","L3000-21","in 10mM DMSO","CXCR","Immunology & Inflammation","Nicotinamide N-oxide (Nicotinamide 1-oxide, 1-oxynicotinamide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. Nicotinamide N-oxide is novel, potent, and selective antagonists of the  CXCR2 receptor.",138.12,"1986-81-8",{"v":8,"d":"8.00"},57.92,"N/A","N/A","http://selleckchem.com/products/nicotinamide-n-oxide.html","C6H6N2O2","free base","Nicotinamide 1-oxide, 1-oxynicotinamide, 1-Oxy-nicotinamide","NC(=O)C1=CC=C[N+](=C1)[O-]",{"v":0,"d":"0.000"},0,0,0]
["S4787","Methyl syringate","c3","L3000-21","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.",{"v":212.2,"d":"212.20"},"884-35-5",{"v":42,"d":"42.00"},197.93,"N/A","N/A","http://selleckchem.com/products/methyl-syringate.html","C10H12O5","free base","Syringic Acid Methyl Ester","COC(=O)C1=CC(=C(O)C(=C1)OC)OC",{"v":0,"d":"0.000"},0,0,0]
["S4797","Nicergoline","d3","L3000-21","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions.",484.39,"27848-84-6",{"v":22,"d":"22.00"},45.42,"N/A","N/A","http://selleckchem.com/products/nicergoline.html","C24H26BrN3O3","free base","N/A","COC12CC(COC(=O)C3=CN=CC(=C3)Br)CN(C)C1CC4=C[N](C)C5=CC=CC2=C45",{"v":0,"d":"0.000"},0,0,0]
["S4799","Indole-3-acetic acid","e3","L3000-21","in 10mM DMSO","Others","Others","Indole-3-acetic acid (indolylacetic acid, 1H-Indole-3-acetic acid, indoleacetic acid, heteroauxin, IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development.",175.18,"87-51-4",{"v":35,"d":"35.00"},199.79,"N/A","N/A","http://selleckchem.com/products/indole-3-acetic-acid.html","C10H9NO2","free base","indolylacetic acid, 1H-Indole-3-acetic acid, indoleacetic acid, heteroauxin, IAA","OC(=O)CC1=C[NH]C2=C1C=CC=C2",{"v":0,"d":"0.000"},0,0,0]
["S4807","Uracil 1-β-D-arabinofuranoside","f3","L3000-21","in 10mM DMSO","Others","Others","Uracil 1-β-D-arabinofuranoside (Spongouridine, Arauridine, 1-beta-D-Arabinofuranosyluracil, Ara-U) is a deamination metabolite of Cytarabine.",{"v":244.2,"d":"244.20"},"3083-77-0",{"v":48,"d":"48.00"},196.56,"N/A","N/A","http://selleckchem.com/products/uracil-1-beta-d-arabinofuranoside.html","C9H12N2O6","free base","Spongouridine, Arauridine, 1-beta-D-Arabinofuranosyluracil, Ara-U","OCC1OC(C(O)C1O)N2C=CC(=O)NC2=O",{"v":0,"d":"0.000"},0,0,0]
["S4817","Atenolol","g3","L3000-21","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.",266.34,"29122-68-7",{"v":53,"d":"53.00"},198.99,{"v":35,"d":"35.00"},131.41,"http://selleckchem.com/products/atenolol.html","C14H22N2O3","free base","Tenormin, Normiten, Blokium","CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1",0.669,2,3,8]
["S4832","Tolmetin","h3","L3000-21","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.",257.28,"26171-23-3",{"v":51,"d":"51.00"},198.23,"N/A","N/A","http://selleckchem.com/products/tolmetin.html","C15H15NO3","free base","Tolectin","C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(O)=O",3.267,2,0,4]
["S4833","Cefoxitin sodium","a4","L3000-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefoxitin Sodium is the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.",449.43,"33564-30-6",{"v":89,"d":"89.00"},198.03,{"v":89,"d":"89.00"},198.03,"http://selleckchem.com/products/cefoxitin-sodium.html","C16H16N3O7S2.Na","sodium salt","N/A","[Na+].COC1(NC(=O)CC2=CC=CS2)C3SCC(=C(N3C1=O)C([O-])=O)COC(N)=O",-1.151,5,2,8]
["S4834","Propantheline bromide","b4","L3000-21","in 10mM DMSO","AChR","Neuronal Signaling","Propantheline bromide (Pro-Banthine, Neometantyl, Neopepulsan) is a muscarinic antagonist used to treat gastrointestinal conditions associated with intestinal spasm and to decrease secretions during anesthesia.",448.39,"50-34-0",{"v":89,"d":"89.00"},198.49,"N/A","N/A","http://selleckchem.com/products/propantheline-bromide.html","C23H30NO3.Br","bromide","Pro-Banthine, Neometantyl, Neopepulsan","[Br-].CC(C)[N+](C)(CCOC(=O)C1C2=C(OC3=CC=CC=C13)C=CC=C2)C(C)C",0.763,3,0,7]
["S4835","Aceclofenac","c4","L3000-21","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.",354.18,"89796-99-6",{"v":70,"d":"70.00"},197.64,"N/A","N/A","http://selleckchem.com/products/aceclofenac.html","C16H13Cl2NO4","free base","Preservex, Airtal","OC(=O)COC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",{"v":4.08,"d":"4.080"},3,1,7]
["S4836","Nilutamide","d4","L3000-21","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.",317.22,"63612-50-0",{"v":63,"d":"63.00"},{"v":198.6,"d":"198.60"},"<1","N/A","http://selleckchem.com/products/nilutamide.html","C12H10F3N3O4","Nonsteroidal antiandrogens","RU23908","CC1(C)NC(=O)N(C2=CC=C(C(=C2)C(F)(F)F)[N+]([O-])=O)C1=O",2.254,2,1,3]
["S4837","Ibudilast","e4","L3000-21","in 10mM DMSO","PDE","Metabolism","Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.",230.31,"50847-11-5",{"v":46,"d":"46.00"},199.73,{"v":30,"d":"30.00"},130.26,"http://selleckchem.com/products/Ibudilast.html","C14H18N2O","free base","KC-404, AV411, MN166","CC(C)C(=O)C1=C2C=CC=C[N]2N=C1C(C)C",3.339,2,0,3]
["S4838","Acotiamide hydrochloride","f4","L3000-21","in 10mM DMSO","AChR","Neuronal Signaling","Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.",541.06,"773092-05-0",{"v":100,"d":"100.00"},184.82,{"v":5,"d":"5.00"},9.24,"http://selleckchem.com/products/acotiamide-hydrochloride.html","C21H30N4O5S.HCl.3H2O","hydrochloride trihydrate","YM-443 HCl, Z-338 HCl","O.O.O.Cl.COC1=CC(=C(C=C1OC)C(=O)NC2=NC(=CS2)C(=O)NCCN(C(C)C)C(C)C)O",2.325,5,3,10]
["S4849","Levocetirizine Dihydrochloride","g4","L3000-21","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.",461.81,"130018-87-0",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/levocetirizine-dihydrochloride.html","C21H25ClN2O3.2HCl","dihydrochloride","Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S4852","Gadopentetate Dimeglumine","h4","L3000-21","in 10mM DMSO","Others","Others","Gadopentetate Dimeglumine (Gadopentetic acid dimeglumine, Gd-DTPA, Meglumine gadopentetate), a complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, is an extracellular intravenous contrast agent used in magnetic resonance imaging.",{"v":938,"d":"938.00"},"86050-77-3",{"v":100,"d":"100.00"},106.61,"N/A","N/A","http://selleckchem.com/products/gadopentetate-dimeglumine.html","C14H18GdN3O10.2C7H17NO5.2H","dimeglumine salt","Gadopentetic acid dimeglumine, Gd-DTPA, Meglumine gadopentetate","CNCC(O)C(O)C(O)C(O)CO.CNCC(O)C(O)C(O)C(O)CO.OC(=O)CN1CCN2CCN(CC(O)=O)CC(=O)O[Gd](OC(=O)C2)OC(=O)C1",-13.058,8,12,16]
["S4856","Iproniazid","a5","L3000-21","in 10mM DMSO","MAO","Metabolism","Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.",179.22,"54-92-2",{"v":35,"d":"35.00"},195.29,{"v":35,"d":"35.00"},195.29,"http://selleckchem.com/products/Iproniazid.html","C9H13N3O","free base","Marsilid, Iprazid","CC(C)NNC(=O)C1=CC=NC=C1",0.121,2,2,3]
["S4861","Oxindole","b5","L3000-21","in 10mM DMSO","Bacterial,HIV","Microbiology","Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. Oxindole has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.",133.15,"59-48-3",{"v":26,"d":"26.00"},195.27,"N/A","N/A","http://selleckchem.com/products/oxindole.html","C8H7NO","free base","2-indolone, 2-Oxindole, Indolin-2-one","O=C1CC2=C(N1)C=CC=C2",0.819,1,1,0]
["S4862","Squalene","c5","L3000-21","in 10mM DMSO","Fungal","Microbiology","Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.",410.72,"111-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/squalene.html","C30H50","free base","Spinacene, Supraene, trans-Squalene","CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(C)\\CC\\C=C(C)\\CCC=C(C)C",11.331,0,0,15]
["S4867","Propacetamol hydrochloride","d5","L3000-21","in 10mM DMSO","Others","Others","Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders.",300.78,"66532-86-3",{"v":60,"d":"60.00"},199.48,{"v":60,"d":"60.00"},199.48,"http://selleckchem.com/products/propacetamol-hydrochloride.html","C14H20N2O3.HCl","hydrochloride","N/A","Cl.CCN(CC)CC(=O)OC1=CC=C(NC(C)=O)C=C1",1.803,3,1,7]
["S4878","Neticonazole Hydrochloride","e5","L3000-21","in 10mM DMSO","Fungal","Microbiology","Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.",{"v":338.9,"d":"338.90"},"130773-02-3",{"v":67,"d":"67.00"},{"v":197.7,"d":"197.70"},"N/A","N/A","http://selleckchem.com/products/neticonazole-hydrochloride.html","C17H22N2OS.HCl","hydrochloride","N/A","Cl.CCCCCOC1=CC=CC=C1C(=C\\SC)/[N]2C=CN=C2",3.838,2,0,8]
["S4885","Taurolidine","f5","L3000-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.",284.36,"19388-87-5",{"v":56,"d":"56.00"},196.93,"N/A","N/A","http://selleckchem.com/products/taurolidine.html","C7H16N4O4S2","free base","Taurolin, Tauroline, Tauroflex","O=[S]1(=O)CCN(CN1)CN2CC[S](=O)(=O)NC2",-1.991,4,2,2]
["S4892","Phenibut","g5","L3000-21","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.",179.22,"1078-21-3",{"v":35,"d":"35.00"},195.29,"N/A","N/A","http://selleckchem.com/products/phenibut.html","C10H13NO2","free base","Aminophenylbutyric acid, Fenibut, Fenigam, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA","NCC(CC(O)=O)C1=CC=CC=C1",-1.724,1,1,4]
["S4896","Elagolix Sodium","h5","L3000-21","in 10mM DMSO","GNRH Receptor","Endocrinology & Hormones","Elagolix Soidum (NBI-56418, ABT-620) is a potent, selective, orally active, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with Kd value of 54 pM. Concentration at 10 μM shows no significant activity on ion channels, enzymes, and transporters (inhibition <50%).",653.57,"832720-36-2",{"v":100,"d":"100.00"},153.01,{"v":100,"d":"100.00"},153.01,"http://selleckchem.com/products/elagolix-sodium.html","C32H29F5N3O5.Na","sodium","NBI-56418, ABT-620","[Na+].COC1=C(F)C(=CC=C1)C2=C(C)N(CC3=C(F)C=CC=C3C(F)(F)F)C(=O)N(CC(NCCCC([O-])=O)C4=CC=CC=C4)C2=O",4.104,3,1,13]
["S4900","Tenovin-6","a6","L3000-21","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.",454.63,"1011557-82-6",{"v":98,"d":"98.00"},215.56,{"v":98,"d":"98.00"},215.56,"http://selleckchem.com/products/tenovin-6.html","C25H34N4O2S","free base","N/A","Cl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",{"v":5.7,"d":"5.700"},2,3,11]
["S4901","JNK-IN-8","b6","L3000-21","in 10mM DMSO","JNK","MAPK","JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.",507.59,"1410880-22-6",{"v":100,"d":"100.00"},197.01,"<1","N/A","http://selleckchem.com/products/jnk-in-8.html","C29H29N7O2","free base","JNK Inhibitor XVI","CN(C)C/C=C/C(=O)NC1=CC(=CC=C1)C(=O)NC2=CC=C(NC3=NC=CC(=N3)C4=CC=CN=C4)C(=C2)C",3.997,5,3,9]
["S4902","QNZ (EVP4593)","c6","L3000-21","in 10mM DMSO","NF-κB,TNF-alpha","NF-κB","QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.",356.42,"545380-34-5",{"v":5,"d":"5.00"},14.03,"<1","N/A","http://selleckchem.com/products/qnz-evp4593.html","C22H20N4O","free base","N/A","NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1",4.454,3,2,6]
["S4904","JZL184","d6","L3000-21","in 10mM DMSO","Lipase","Metabolism","JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.",520.49,"1101854-58-3",{"v":100,"d":"100.00"},192.13,"<1","N/A","http://selleckchem.com/products/jzl184.html","C27H24N2O9","free base","N/A","OC(C1CCN(CC1)C(=O)OC2=CC=C(C=C2)[N+]([O-])=O)(C3=CC=C4OCOC4=C3)C5=CC=C6OCOC6=C5",4.292,6,0,6]
["S4907","SC-514","e6","L3000-21","in 10mM DMSO","IκB/IKK","NF-κB","SC-514 (GK 01140) is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.",{"v":224.3,"d":"224.30"},"354812-17-2",{"v":45,"d":"45.00"},200.62,"<1","N/A","http://selleckchem.com/products/sc-514.html","C9H8N2OS2","free base","GK 01140","NC(=O)C1=C(N)C=C(S1)C2=CSC=C2",{"v":1.51,"d":"1.510"},1,2,2]
["S4908","SN-38","f6","L3000-21","in 10mM DMSO","ADC Cytotoxin,Autophagy,Topoisomerase","DNA Damage/DNA Repair","SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.",{"v":392.4,"d":"392.40"},"86639-52-3",{"v":21,"d":"21.00"},53.52,"<1","N/A","http://selleckchem.com/products/sn-38.html","C22H20N2O5","free base","NK012","CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=C1C=C(O)C=C5)C(O)(CC)C(=O)OC4",2.446,4,1,2]
["S4920","b-AP15","g6","L3000-21","in 10mM DMSO","DUB","Ubiquitin","b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.",419.39,"1009817-63-3",{"v":48,"d":"48.00"},114.45,"<1","N/A","http://selleckchem.com/products/b-ap15.html","C22H17N3O6","free base","NSC687852","[O-][N+](=O)C1=CC=C(C=C1)\\C=C2/CN(C\\C(=C/C3=CC=C(C=C3)[N+]([O-])=O)C2=O)C(=O)C=C",3.653,2,0,5]
["S4921","MNS (3,4-Methylenedioxy-β-nitrostyrene)","h6","L3000-21","in 10mM DMSO","p97,Src,Syk,Tyrosinase","Ubiquitin","MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.",193.16,"1485-00-3",{"v":39,"d":"39.00"},201.91,"<1","N/A","http://selleckchem.com/products/mdbn.html","C9H7NO4","free base","MDBN","[O-][N+](=O)/C=C/C1=CC2=C(OCO2)C=C1",1.578,2,0,2]
["S4932","Proxyphylline","a7","L3000-21","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Proxyphylline (Monophylline, Spasmolysin) is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 µM for platelets).",238.24,"603-00-9",{"v":47,"d":"47.00"},197.28,"N/A","N/A","http://selleckchem.com/products/proxyphylline.html","C10H14N4O3","free base","Monophylline, Spasmolysin","CC(O)C[N]1C=NC2=C1C(=O)N(C)C(=O)N2C",-0.262,3,1,2]
["S4938","Cedrol","b7","L3000-21","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Cedrol, a natural occuring sesquiterpene alcohol, is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.",222.37,"77-53-2",{"v":44,"d":"44.00"},197.87,"N/A","N/A","http://selleckchem.com/products/cedrol.html","C15H26O","free base","N/A","CC1CCC2C(C)(C)C3CC12CCC3(C)O",3.157,0,0,0]
["S4940","Maltol","c7","L3000-21","in 10mM DMSO","Antioxidant","PI3K/Akt/mTOR","Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.",126.11,"118-71-8",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/maltol.html","C6H6O3","Pyrone","Larixinic acid, Palatone, Veltol","CC1=C(O)C(=O)C=CO1",-0.222,2,1,0]
["S4941","Farnesol","d7","L3000-21","in 10mM DMSO","Antibiotics","Microbiology","Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.",222.37,"4602-84-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/farnesol.html","C15H26O","free base","N/A","CC(C)=CCCC(/C)=C/CCC(/C)=C/CO",{"v":4.76,"d":"4.760"},0,1,7]
["S4952","Fumaric acid","e7","L3000-21","in 10mM DMSO","Others","Others","Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.",116.07,"110-17-8",{"v":23,"d":"23.00"},198.16,"N/A","N/A","http://selleckchem.com/products/fumaric-acid.html","C4H4O4","free base","2-Butenedioic acid, Trans-Butenedioic acid, Allomaleic acid, Boletic acid, Donitic acid, Lichenic acid, Fumarate","OC(=O)\\C=C\\C(O)=O",0.038,2,0,2]
["S4953","Usnic acid","f7","L3000-21","in 10mM DMSO","Akt,ERK","PI3K/Akt/mTOR","Usnic acid (Usniacin) is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. It exhibits antiviral, antiprotozoal, antiproliferative, anti-inflammatory and analgesic activity. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways.",344.32,"125-46-2",{"v":4,"d":"4.00"},11.62,"N/A","N/A","http://selleckchem.com/products/usnic-acid.html","C18H16O7","free base","Usniacin","CC(=O)C1C(=O)C=C2OC3=C(C(=C(C)C(=C3C(C)=O)O)O)C2(C)C1=O",1.084,5,2,2]
["S4957","Linalool","g7","L3000-21","in 10mM DMSO","NMDAR","Neuronal Signaling","Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.",154.25,"78-70-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/linalool.html","C10H18O","free base","Phantol","CC(C)=CCCC(C)(O)C=C",2.735,0,0,4]
["S4958","Glycocholic acid","h7","L3000-21","in 10mM DMSO","Others","Others","Glycocholic acid (Cholylglycine, Glycocholate) is a natural secondary bile acid involved in the emulsification of fats.",465.62,"475-31-0",{"v":93,"d":"93.00"},199.73,"N/A","N/A","http://selleckchem.com/products/glycocholic-acid.html","C26H43NO6","free base","Cholylglycine, Glycocholate","CC(CCC(=O)NCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",1.972,2,4,6]
["S4966","4-Methylesculetin","a8","L3000-21","in 10mM DMSO","Immunology & Inflammation related,Interleukins,Peroxidases","Metabolism","4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.",192.17,"529-84-0",{"v":38,"d":"38.00"},197.74,"N/A","N/A","http://selleckchem.com/products/methylesculetin.html","C10H8O4","free base","N/A","CC1=CC(=O)OC2=C1C=C(O)C(=C2)O",1.862,2,2,0]
["S4975","Fimasartan","b8","L3000-21","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.",501.65,"247257-48-3",{"v":100,"d":"100.00"},199.34,"N/A","N/A","http://selleckchem.com/products/fimasartan.html","C27H31N7OS","free base","Kanarb","CCCCC1=NC(=C(CC(=S)N(C)C)C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[NH]4)C",4.515,5,1,10]
["S4976","Sulfalene (SMPZ)","c8","L3000-21","in 10mM DMSO","Others","Others","Sulfalene (SMPZ, Butadiene sulfone, 3-Sulfolene) is a cyclic organic chemical used as a versatile synthetic intermediate.",{"v":280.3,"d":"280.30"},"152-47-6",{"v":56,"d":"56.00"},199.79,"<1","N/A","http://selleckchem.com/products/sulfalene-smpz.html","C11H12N4O3S","free base","Butadiene sulfone, 3-Sulfolene","COC1=C(N[S](=O)(=O)C2=CC=C(N)C=C2)N=CC=N1",0.331,5,2,4]
["S4977","Efonidipine","d8","L3000-21","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.",631.66,"111011-63-3",{"v":100,"d":"100.00"},158.31,"N/A","N/A","http://selleckchem.com/products/efonidipine.html","C34H38N3O7P","free base","NZ-105","CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",4.956,4,1,11]
["S4980","Anamorelin","e8","L3000-21","in 10mM DMSO","GHSR","GPCR & G Protein","Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN  FLIPR assay.",{"v":546.7,"d":"546.70"},"249921-19-5",{"v":100,"d":"100.00"},182.92,"<1","N/A","http://selleckchem.com/products/anamorelin.html","C31H42N6O3","free base","ONO-7643, RC-1291, ST-1291","CN(C)N(C)C(=O)C1(CCCN(C1)C(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(C)(C)N)CC4=CC=CC=C4",2.447,3,3,9]
["S4984","2,2'-Cyclouridine","f8","L3000-21","in 10mM DMSO","Others","Others","2,2'-Cyclouridine is a research tool for antiviral and anticancer studies.",226.19,"3736-77-4",{"v":45,"d":"45.00"},198.95,{"v":-1,"d":"-1.00"},-4.42,"http://selleckchem.com/products/2-2-cyclouridine.html","C9H10N2O5","free base","N/A","OCC1OC2C(OC3=NC(=O)C=CN23)C1O",-1.185,4,2,1]
["S4988","Tiamulin fumarate","g8","L3000-21","in 10mM DMSO","Ribosomal Peptidyl Transferase","Microbiology","Tiamulin fumarate is a semisynthetic pleuromutilin antibiotic that binds to the ribosomal peptidyl transferase centre and inhibits protein synthesis.",609.81,"55297-96-6",{"v":100,"d":"100.00"},163.99,{"v":100,"d":"100.00"},163.99,"http://selleckchem.com/products/tiamulin-fumarate.html","C28H47NO4S.C4H4O4","fumarate","N/A","CCN(CC)CCSCC(=O)OC1CC(C)(C=C)C(O)C(C)C23CCC(C)C1(C)C2C(=O)CC3.OC(=O)\\C=C\\C(O)=O",1.366,5,1,12]
["S4989","AOA hemihydrochloride","h8","L3000-21","in 10mM DMSO","Transferase","Metabolism","AOA hemihydrochloride (Aminooxyacetic acid, Carboxymethoxylamine, AOAA, Aminooxyacetate hemihydrochloride) is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor.",{"v":109.3,"d":"109.30"},"2921-14-4",{"v":21,"d":"21.00"},192.13,"N/A","N/A","http://selleckchem.com/products/aminooxyacetic-acid-hemihydrochloride.html","C2H5NO3.1/2HCl","hemihydrochloride","Aminooxyacetic acid hemihydrochloride, Carboxymethoxylamine hemihydrochloride, AOAA hemihydrochloride, Aminooxyacetate hemihydrochloride","NOCC(O)=O",-0.432,2,1,2]
["S4990","TBHQ","a9","L3000-21","in 10mM DMSO","Nrf2","Immunology & Inflammation","Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.",166.22,"1948-33-0",{"v":33,"d":"33.00"},198.53,"N/A","N/A","http://selleckchem.com/products/tbhq.html","C10H14O2","free base","Tert-butylhydroquinone","CC(C)(C)C1=C(O)C=CC(=C1)O",2.746,0,2,1]
["S4997","4-Butylresorcinol","b9","L3000-21","in 10mM DMSO","Tyrosinase","Proteases","4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.",166.22,"18979-61-8",{"v":34,"d":"34.00"},204.55,{"v":-1,"d":"-1.00"},-6.02,"https://www.selleckchem.com/products/4-butylresorcinol.html","C10H14O2","Resorcinol","4-n-Butylresorcinol, Rucinol","CCCCC1=CC=C(O)C=C1O",{"v":3.2,"d":"3.200"},0,2,3]
["S4998","2-Aminobenzenesulfonamide","c9","L3000-21","in 10mM DMSO","Carbonic Anhydrase","Metabolism","2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.",{"v":172.2,"d":"172.20"},"3306-62-5",{"v":34,"d":"34.00"},197.44,"N/A","N/A","https://www.selleckchem.com/products/2-aminobenzenesulfonamide.html","C6H8N2O2S","Sulfonamides","Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide","NC1=CC=CC=C1[S](N)(=O)=O",-0.212,2,2,1]
["S5001","Tofacitinib (CP-690550) Citrate","d9","L3000-21","in 10mM DMSO","Anti-infection,JAK","JAK/STAT","Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.",504.49,"540737-29-9",{"v":100,"d":"100.00"},198.22,"<1","N/A","http://selleckchem.com/products/CP-690550.html","C16H20N6O.C6H8O7","Citrate","Tasocitinib Citrate,CP-690550","CC1CCN(CC1N(C)C2=C3C=C[NH]C3=NC=N2)C(=O)CC#N.OC(=O)CC(O)(CC(O)=O)C(O)=O",0.193,6,1,8]
["S5002","Fingolimod (FTY720) HCl","e9","L3000-21","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.",{"v":343.9,"d":"343.90"},"162359-56-0",{"v":69,"d":"69.00"},200.64,{"v":69,"d":"69.00"},200.64,"http://selleckchem.com/products/FTY720.html","C19H33NO2.HCl","Hydrochloride","Fingolimod Hydrochloride,FTY720","Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",{"v":4.58,"d":"4.580"},0,3,12]
["S5003","Tacrolimus (FK506)","f9","L3000-21","in 10mM DMSO","Autophagy,FKBP,phosphatase","PI3K/Akt/mTOR","Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.",804.02,"104987-11-3",{"v":94,"d":"94.00"},116.91,"<1","N/A","http://selleckchem.com/products/FK-506-(Tacrolimus).html","C44H69NO12","free base","FK506, FR900506, Fujimycin, Prograf","COC1CC(CCC1O)\\C=C(C)\\C2OC(=O)C3CCCCN3C(=O)C(=O)C4(O)OC(C(CC(C)C/C(=C/C(CC=C)C(=O)CC(O)C2C)C)OC)C(CC4C)OC",4.832,9,2,7]
["S5006","Teprenone","g9","L3000-21","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Teprenone, an acylic polyisoprenoid, that is known as tetraprenylacetone or geranylgeranylacetone, is an anti-ulcer drug, clinically used for gastritis.  Teprenone(Geranylgeranylacetone) is an inducer of heat shock proteins (HSPs) expression.",330.55,"6809-52-5",{"v":66,"d":"66.00"},199.67,"N/A","N/A","http://selleckchem.com/products/teprenone.html","C23H38O","Isoprenoids","Geranylgeranylacetone, Tetraprenylacetone","CC(C)=CCC/C(C)=C/CC\\C(C)=C\\CC\\C(C)=C\\CCC(C)=O",7.413,1,0,12]
["S5007","Delamanid","h9","L3000-21","in 10mM DMSO","Bacterial","Microbiology","Delamanid (OPC-67683) is a new anti-tuberculosis drug with an excellent intracellular bactericidal activity and a high accumulation rate.",534.48,"681492-22-8",{"v":100,"d":"100.00"},{"v":187.1,"d":"187.10"},"<1","N/A","http://selleckchem.com/products/delamanid.html","C25H25F3N4O6","free base","OPC-67683","CC1(COC2=CC=C(C=C2)N3CCC(CC3)OC4=CC=C(OC(F)(F)F)C=C4)C[N]5C=C(N=C5O1)[N+]([O-])=O",6.452,5,0,9]
["S5009","Brivudine","a10","L3000-21","in 10mM DMSO","CMV","Microbiology","Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.",333.14,"69304-47-8",{"v":66,"d":"66.00"},198.11,"N/A","N/A","http://selleckchem.com/products/brivudine.html","C11H13BrN2O5","free base","BVDU","OCC1OC(CC1O)N2C=C(\\C=C\\Br)C(=O)NC2=O",-1.034,3,3,3]
["S5012","Octenidine Dihydrochloride","b10","L3000-21","in 10mM DMSO","Bacterial","Microbiology","Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.",623.83,"70775-75-6",{"v":60,"d":"60.00"},96.18,"N/A","N/A","http://selleckchem.com/products/octenidine-ihydrochloride.html","C36H62N4.2HCl","Dihydrochloride","N/A","Cl.Cl.CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1",{"v":10.56,"d":"10.560"},2,0,25]
["S5014","Crisaborole (AN2728)","c10","L3000-21","in 10mM DMSO","PDE","Metabolism","Crisaborole (AN2728) is a small-molecule, boron-based, selective PDE4 inhibitor and has broad-spectrum anti-inflammatory activity.",251.05,"906673-24-3",{"v":50,"d":"50.00"},199.16,"N/A","N/A","http://selleckchem.com/products/crisaborole-an2728.html","C14H10BNO3","free base","N/A","OB1OCC2=CC(=CC=C12)OC3=CC=C(C=C3)C#N",3.538,2,0,2]
["S5016","Isoprinosine","d10","L3000-21","in 10mM DMSO","Antiviral,Immunology & Inflammation related","Microbiology","Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.",1115.23,"36703-88-5",{"v":100,"d":"100.00"},89.67,{"v":100,"d":"100.00"},89.67,"http://selleckchem.com/products/isoprinosine.html","C10H12N4O5.3C9H9NO3.3C5H13NO","salt","Inosine pranobex, Immunovir, Groprinosin, Delimmun","CC(O)CN(C)C.CC(O)CN(C)C.CC(O)CN(C)C.CC(=O)NC1=CC=C(C=C1)C(O)=O.CC(=O)NC2=CC=C(C=C2)C(O)=O.CC(=O)NC3=CC=C(C=C3)C(O)=O.OCC4OC(C(O)C4O)[N]5C=NC6=C5N=CNC6=O",-9.137,10,10,14]
["S5020","Tilorone dihydrochloride","e10","L3000-21","in 10mM DMSO","Antiviral,IFN","Immunology & Inflammation","Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.",483.47,"27591-69-1",{"v":43,"d":"43.00"},88.94,{"v":96,"d":"96.00"},198.56,"http://selleckchem.com/products/tilorone-dihydrochloride.html","C25H34N2O3.2HCl","dihydrochloride","N/A","Cl.Cl.CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C=C(OCCN(CC)CC)C=C3)C2=O",5.326,3,0,12]
["S5023","Nadolol","f10","L3000-21","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.",{"v":309.4,"d":"309.40"},"42200-33-9",{"v":61,"d":"61.00"},197.16,"N/A","N/A","http://selleckchem.com/products/nadolol.html","C17H27NO4","free base","Corgard, Solgol, Anabet, SQ11725","CC(C)(C)NCC(O)COC1=CC=CC2=C1CC(O)C(O)C2",1.146,1,4,6]
["S5027","Mebeverine Hydrochloride","g10","L3000-21","in 10mM DMSO","Others","Others","Mebeverine (Duspatalin, Duspatal, Colofac), a 3-phenylethylamine derivative of methoxybenzamine, acts as a musculotropic antispasmodic agent.",466.01,"2753-45-9",{"v":93,"d":"93.00"},199.57,"N/A","N/A","http://selleckchem.com/products/mebeverine-hydrochlo.html","C25H35NO5.HCl","hydrochloride","Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride","Cl.CCN(CCCCOC(=O)C1=CC=C(OC)C(=C1)OC)C(C)CC2=CC=C(OC)C=C2",{"v":5.43,"d":"5.430"},5,0,14]
["S5029","Etofylline","h10","L3000-21","in 10mM DMSO","Others","Others","Etofylline (Aethophyllinum, Cordalin, Oxyphylline) is a N-7 substituted theophylline derivative used as a bronchodilator.",224.22,"519-37-9",{"v":44,"d":"44.00"},196.24,{"v":44,"d":"44.00"},196.24,"http://selleckchem.com/products/etofylline.html","C9H12N4O3","Methylxanthines","Aethophyllinum, Cordalin, Oxyphylline","CN1C(=O)N(C)C2=C([N](CCO)C=N2)C1=O",{"v":-0.64,"d":"-0.640"},3,1,2]
["S5032","Mephenesin","a11","L3000-21","in 10mM DMSO","NMDAR","Neuronal Signaling","Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.",182.22,"59-47-2",{"v":36,"d":"36.00"},197.56,{"v":30,"d":"30.00"},164.64,"http://selleckchem.com/products/mephenesin.html","C10H14O3","free base","Decontractyl, Cresoxydiol, Memphenesin, Mephedan","CC1=C(OCC(O)CO)C=CC=C1",1.249,1,2,4]
["S5033","Terconazole","b11","L3000-21","in 10mM DMSO","Fungal","Microbiology","Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470) is a new, broad-spectrum, triazole antifungal agent which is primarily used to treat vaginal fungal infections.",532.46,"67915-31-5",{"v":49,"d":"49.00"},92.03,"<1","N/A","http://selleckchem.com/products/terconazole.html","C26H31Cl2N5O3","free base","Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470","CC(C)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=NC=N4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",4.949,5,0,8]
["S5040","Tiamulin","c11","L3000-21","in 10mM DMSO","Ribosomal Peptidyl Transferase","Microbiology","Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the ribosomal peptidyl transferase centre and inhibits protein synthesis. Tiamulin has sustained antibacterial activity against specified bacterial species and rapidly growing and fastidious animal pathogens.",493.74,"55297-95-5",{"v":25,"d":"25.00"},50.63,{"v":11,"d":"11.00"},22.28,"http://selleckchem.com/products/tiamulin.html","C28H47NO4S","free base","N/A","CCN(CC)CCSCC(=O)OC1CC(C)(C=C)C(O)C(C)C23CCC(C)C1(C)C2C(=O)CC3",4.361,3,1,10]
["S5045","Nomilin","d11","L3000-21","in 10mM DMSO","Apoptosis related","MAPK","Nomilin is a triterpenoid present in common edible citrus fruits with putative anticancer properties.",514.56,"1063-77-0",{"v":100,"d":"100.00"},194.34,"<1","N/A","http://selleckchem.com/products/nomilin.html","C28H34O9","free base","N/A","CC(=O)OC1CC(=O)OC(C)(C)C2CC(=O)C3(C)C(CCC4(C)C(OC(=O)C5OC345)C6=COC=C6)C12C",2.151,9,0,3]
["S5049","Thiocolchicoside","e11","L3000-21","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.",563.62,"602-41-5",{"v":100,"d":"100.00"},177.42,{"v":100,"d":"100.00"},177.42,"http://selleckchem.com/products/thiocolchicoside.html","C27H33NO10S","Phenolic glycosides","Thiocolchicine 2-glucoside analog, Coltramyl","COC1=C(OC)C2=C(CCC(NC(C)=O)C3=CC(=O)C(=CC=C23)SC)C=C1OC4OC(CO)C(O)C(O)C4O",0.446,6,5,7]
["S5052","Granisetron","f11","L3000-21","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.",312.41,"109889-09-0",{"v":11,"d":"11.00"},35.21,"N/A","N/A","http://selleckchem.com/products/granisetron.html","C18H24N4O","Serotonin 5-HT3 receptor","Sancuso, Kevatril, Granisetronum, Sustol","CN1C2CCCC1CC(C2)NC(=O)C3=N[N](C)C4=C3C=CC=C4",2.401,2,1,2]
["S5058","Revaprazan Hydrochloride","g11","L3000-21","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.",{"v":398.9,"d":"398.90"},"178307-42-1",{"v":16,"d":"16.00"},40.11,"N/A","N/A","http://selleckchem.com/products/revaprazan-hydrochloride.html","C22H23FN4.HCl","HCl","YH1885","Cl.CC1N(CCC2=C1C=CC=C2)C3=NC(=NC(=C3C)C)NC4=CC=C(F)C=C4",6.215,2,1,3]
["S5059","Pixantrone Maleate","h11","L3000-21","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.",557.51,"144675-97-8",{"v":100,"d":"100.00"},179.37,{"v":100,"d":"100.00"},179.37,"http://selleckchem.com/products/pixantrone-maleate.html","C17H19N5O2.2C4H4O4","dimaleate","BBR-2778","NCCNC1=CC=C(NCCN)C2=C1C(=O)C3=C(C=NC=C3)C2=O.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",-5.263,7,4,10]
["S5060","Metadoxine","a2","L3000-22","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.  Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.",298.29,"74536-44-0",{"v":59,"d":"59.00"},197.79,"N/A","N/A","http://selleckchem.com/products/metadoxine.html","C8H11NO3.C5H7NO3","salt","Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat","CC1=C(O)C(=C(CO)C=N1)CO.OC(=O)C2CCC(=O)N2",-1.243,3,4,3]
["S5062","Daclatasvir Dihydrochloride","b2","L3000-22","in 10mM DMSO","HCV Protease","Microbiology","Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection.",{"v":811.8,"d":"811.80"},"1009119-65-6",{"v":100,"d":"100.00"},123.18,{"v":100,"d":"100.00"},123.18,"https://www.selleckchem.com/products/daclatasvir-dihydrochloride.html","C40H50N8O6.2HCl","dihydrochloride","N/A","Cl.Cl.COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C([NH]5)C6CCCN6C(=O)C(NC(=O)OC)C(C)C",5.812,8,4,13]
["S5067","Losartan","c2","L3000-22","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Losartan(DuP-753) is a selective, orally administered, nonpeptide blocker of angiotensin II type 1 (AT1) receptor used to treat high blood pressure, diabetic kidney disease, heart failure, and left ventricular enlargement.",422.91,"114798-26-4",{"v":84,"d":"84.00"},198.62,{"v":-1,"d":"-1.00"},-2.36,"https://www.selleckchem.com/products/losartan.html","C22H23ClN6O","free base","DuP-753","CCCCC1=NC(=C(CO)[N]1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4)Cl",4.241,4,2,8]
["S5069","Dabrafenib Mesylate","d2","L3000-22","in 10mM DMSO","Raf","MAPK","Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.8 nM, 3.2 nM and 5 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.",615.67,"1195768-06-9",{"v":100,"d":"100.00"},162.42,"<1","N/A","http://selleckchem.com/products/dabrafenib-mesylate.html","C23H20F3N5O2S2.CH4O3S","mesylate","GSK2118436 Mesylate","CC(C)(C)C1=NC(=C(S1)C2=CC=NC(=N2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F.C[S](O)(=O)=O",4.963,5,2,6]
["S5074","Argatroban Monohydrate","e2","L3000-22","in 10mM DMSO","Thrombin","Proteases","Argatroban (Argatroban hydrate, Argipidine,MCI-9038 Monohydrate) is a direct, selective thrombin inhibitor with anticoagulant effects.",526.65,"141396-28-3",{"v":100,"d":"100.00"},189.88,"<1","N/A","http://selleckchem.com/products/argatroban-monohydrate.html","C23H36N6O5S.H2O","Thrombin inhibitors","Argatroban hydrate, Argipidine,MCI-9038 Monohydrate","O.CC1CCN(C(C1)C(O)=O)C(=O)C(CCCNC(N)=N)N[S](=O)(=O)C2=CC=CC3=C2NCC(C)C3",1.059,4,4,10]
["S5077","Regorafenib (BAY-734506) Monohydrate","f2","L3000-22","in 10mM DMSO","c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, Kit (c-Kit), RET (c-RET), RAF-1, B-RAF and B-RAF(V600E) respectively.",500.83,"1019206-88-2",{"v":100,"d":"100.00"},199.67,"N/A","N/A","http://selleckchem.com/products/regorafenib-monohydrate.html","C21H15ClF4N4O3.H2O","monohydrate","Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate","O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F",4.174,4,3,6]
["S5078","Osimertinib mesylate","g2","L3000-22","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.",595.71,"1421373-66-1",{"v":9,"d":"9.00"},15.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/osimertinib-mesylate.html","C29H37N7O5S","mesylate","AZD9291 mesylate","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C.C[S](O)(=O)=O",4.257,4,2,10]
["S5082","Vitamin K2","h2","L3000-22","in 10mM DMSO","Vitamin","Metabolism","Vitamin K2 (Menaquinone) is an important fat-soluble vitamin that plays critical roles in protecting heart and brain, and building strong bones. It also plays an important role in cancer protection.",444.65,"863-61-6",{"v":88,"d":"88.00"},197.91,"N/A","N/A","http://selleckchem.com/products/vitamin-k2.html","C31H40O2","free base","Menaquinone","CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O",{"v":9.5,"d":"9.500"},2,0,11]
["S5083","Lentinan","a3","L3000-22","in 10mM DMSO","Fungal,Immunology & Inflammation related","Immunology & Inflammation","Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.","N/A","37339-90-5",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/lentinan.html","C42H70O35R2","Polysaccharides","A823605, Bromoduline","O(C1C(O)C(CO)OC(OCC2OC(OC3C(O)C(CO)OC(OC4C(O)C(COC5OC(CO)C(O)C(O)C5O)OC(OC6C(O)C(OC(CO)C6O)[*])C4O)C3O)C(O)C(OC7OC(CO)C(O)C(O)C7O)C2O)C1O)[*]",-10.494,14,21,20]
["S5089","4-Isopropylbenzaldehyde","b3","L3000-22","in 10mM DMSO","Others","Others","4-Isopropylbenzaldehyde (Cuminaldehyde, Cuminic aldehyde, Cuminal), a natural organic compound, is a kind of pharmaceutical intermediate with a pleasant smell and contributes to the aroma of essential oils.",{"v":148.2,"d":"148.20"},"122-03-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/4-isopropylbenzaldehyde.html","C10H12O","free base","Cuminaldehyde, Cuminic aldehyde, Cuminal","CC(C)C1=CC=C(C=O)C=C1",2.783,1,0,2]
["S5091","Geranyl acetate","c3","L3000-22","in 10mM DMSO","Others","Apoptosis","Geranyl acetate (Geraniol acetate, Geranyl ethanoate) is a natural organic compound that is used primarily as a component of perfumes for creams and soaps and as a flavoring ingredient. Geranyl acetate exhibits anti-cancer effects by inducing cell apoptosis.",196.29,"105-87-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/geranyl-acetate.html","C12H20O2","free base","Geraniol acetate, Geranyl ethanoate","CC(=O)OC/C=C(C)/CCC=C(C)C",3.313,2,0,6]
["S5104","Tea polyphenol","d3","L3000-22","in 10mM DMSO","Others","Others","Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.","N/A","84650-60-2",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},{"v":100,"d":"100.00"},"N/A","http://selleckchem.com/products/tea-polyphenol.html","N/A","N/A","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S5111","7-Ethylcamptothecin","e3","L3000-22","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.",376.41,"78287-27-1",{"v":20,"d":"20.00"},53.13,"N/A","N/A","http://selleckchem.com/products/7-ethylcamptothecin.html","C22H20N2O4","free base","N/A","CCC1=C2C=CC=CC2=NC3=C1CN4C(=O)C5=C(C=C34)C(O)(CC)C(=O)OC5",{"v":0,"d":"0.000"},0,0,0]
["S5113","Propyl gallate","f3","L3000-22","in 10mM DMSO","PPAR","Metabolism","Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.",{"v":212.2,"d":"212.20"},"121-79-9",{"v":42,"d":"42.00"},197.93,"N/A","N/A","http://selleckchem.com/products/propyl-gallate.html","C10H12O5","free base","Gallic acid propyl esterZ, n-Propyl gallate","CCCOC(=O)C1=CC(=C(O)C(=C1)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5120","Elemicin","g3","L3000-22","in 10mM DMSO","SCD","Metabolism","Elemicin (3,4,5-trimethoxyallylbenzene) is a constituent of the oleoresin and the essential oil of Canarium luzonicum. Elemicin is a constituent of natural aromatic phenylpropanoids present in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1(SCD1) activity in the liver by metabolic activation.",208.25,"487-11-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/elemicin.html","C12H16O3","free base","3,4,5-trimethoxyallylbenzene","COC1=C(OC)C(=CC(=C1)CC=C)OC",{"v":0,"d":"0.000"},0,0,0]
["S5122","Abietic Acid","h3","L3000-22","in 10mM DMSO","Lipoxygenase","Metabolism","Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.",302.45,"514-10-3",{"v":60,"d":"60.00"},198.38,"N/A","N/A","http://selleckchem.com/products/abietic-acid.html","C20H30O2","free base","Sylvic acid, Abietate, L-Abietic acid, Rosin Acid","CC(C)C1=CC2=CCC3C(C)(CCCC3(C)C(O)=O)C2CC1",{"v":0,"d":"0.000"},0,0,0]
["S5130","Taurocholic acid sodium salt hydrate","a4","L3000-22","in 10mM DMSO","Others","Others","Taurocholic acid (Sodium taurocholate hydrate), a bile salt formed in the liver, is the product of conjugation of cholic acid with taurine that is involved in the emulsification of lipids. Its sodium salt is the chief ingredient of the bile of carnivorous animals.","537.68 (anhydrous basis)","345909-26-4",{"v":100,"d":"100.00"},185.98,"N/A","N/A","http://selleckchem.com/products/taurocholic-acid-sodium-salt-hydrate.html","C26H45NO7S.xH2O.Na","sodium salt, hydrate","Sodium taurocholate hydrate","[Na+].CC(CCC(=O)NCC[S]([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",{"v":0,"d":"0.000"},0,0,0]
["S5133","Sodium erythorbate","b4","L3000-22","in 10mM DMSO","Others","Others","Sodium erythorbate (NaE, D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium) is the sodium of erythorbic acid, a highly refined food-grade chemical closely related to vitamin C, synthesized from sugar, and used as a color fixative in preparing cured meats.",198.11,"6381-77-7",{"v":12,"d":"12.00"},60.57,"N/A","N/A","http://selleckchem.com/products/sodium-erythorbate.html","C6H7O6.Na","sodium salt","D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium, Sodium isoascorbate","OCC(O)C1OC(=O)C(=C1O[Na])O",{"v":0,"d":"0.000"},0,0,0]
["S5138","Citral","c4","L3000-22","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.",152.23,"5392-40-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/citral.html","C10H16O","free base","Geranialdehyde","CC(C)=CCCC(/C)=C/C=O",{"v":0,"d":"0.000"},0,0,0]
["S5139","Methyl Dihydrojasmonate","d4","L3000-22","in 10mM DMSO","Others","Others","Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin.",226.31,"24851-98-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/methyl-dihydrojasmonate.html","C13H22O3","free base","Hedione, Kharismal","CCCCCC1C(CCC1=O)CC(=O)OC",{"v":0,"d":"0.000"},0,0,0]
["S5141","Pyrithioxin","e4","L3000-22","in 10mM DMSO","Others","Others","Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.",368.47,"1098-97-1",{"v":60,"d":"60.00"},162.84,"N/A","N/A","http://selleckchem.com/products/pyrithioxin.html","C16H20N2O4S2","free base","Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide","CC1=NC=C(CSSCC2=CN=C(C)C(=C2CO)O)C(=C1O)CO",{"v":0,"d":"0.000"},0,0,0]
["S5144","Neferine","f4","L3000-22","in 10mM DMSO","Akt,Apoptosis related,Autophagy,HIV,NF-κB,Nrf2","NF-κB","Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.",624.77,"2292-16-2",{"v":100,"d":"100.00"},160.06,"N/A","N/A","http://selleckchem.com/products/neferine.html","C38H44N2O6","free base","(R)-1,2-Dimethoxyaporphine","COC1=CC=C(CC2N(C)CCC3=C2C=C(OC4=CC(=CC=C4O)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C(=C3)OC)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5145","Protoporphyrin IX","g4","L3000-22","in 10mM DMSO","Others","Others","Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.",562.66,"553-12-8",{"v":100,"d":"100.00"},177.73,"N/A","N/A","http://selleckchem.com/products/protoporphyrin-ix.html","C34H34N4O4","free base","PPIX","CC1=C2[NH]C(=C1CCC(O)=O)C=C3N=C(C=C4N=C(C=C5[NH]C(=C2)C(=C5C)C=C)C(=C4C)C=C)C(=C3CCC(O)=O)C",{"v":0,"d":"0.000"},0,0,0]
["S5151","Gypenoside","h4","L3000-22","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Gypenoside (GP) is the predominant effective component of Gynostemma pentaphyllum and possesses capacities against inflammation and oxidation., Gypenoside (GP)是绞股蓝中的主要有效成分，具有消炎和抗氧化活性。","N/A","15588-68-8",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/gypenoside.html","N/A","Triterpenoid saponins","N/A","CC1OC(OC2C(OCC(O)C2OC3OCC(O)C(O)C3O)OC4CCC5(C=O)C(CCC6(C)C5CCC7C(CCC67C)C(O)(CCC=C(C)C)COC8OC(CO)C(O)C(O)C8O)C4(C)C)C(O)C(O)C1O",{"v":0,"d":"0.000"},0,0,0]
["S5153","Tetrahydroberberine","a5","L3000-22","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,Dopamine Receptor","Neuronal Signaling","Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.",339.39,"522-97-4",{"v":6,"d":"6.00"},17.68,"N/A","N/A","http://selleckchem.com/products/tetrahydroberberine.html","C20H21NO4","free base","Canadine","COC1=CC=C2CC3N(CCC4=CC5=C(OCO5)C=C34)CC2=C1OC",{"v":3.4,"d":"3.400"},4,0,2]
["S5158","alpha-Naphthoflavone","b5","L3000-22","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.",{"v":272.3,"d":"272.30"},"604-59-1",{"v":31,"d":"31.00"},113.85,"N/A","N/A","http://selleckchem.com/products/alpha-naphthoflavone.html","C19H12O2","free base","7,8-benzoflavone","O=C1C=C(OC2=C3C=CC=CC3=CC=C12)C4=CC=CC=C4",4.044,2,0,1]
["S5159","Doxycycline","c5","L3000-22","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,MMP","Microbiology","Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.",444.43,"564-25-0",{"v":88,"d":"88.00"},198.01,"N/A","N/A","http://selleckchem.com/products/doxycycline.html","C22H24N2O8","free base","Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum","CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5163","7-Methoxycoumarin","d5","L3000-22","in 10mM DMSO","Others","Others","7-Methoxycoumarin (Herniarine), also known as Herniarin, is a methoxy derivative of coumarin and substrate for dealkylase. It has been used in the synthesis of anti-first-pass effect compounds and detergents.",176.17,"531-59-9",{"v":35,"d":"35.00"},198.67,"N/A","N/A","http://selleckchem.com/products/7-methoxycoumarin.html","C10H8O3","free base","Herniarin, Herniarine","COC1=CC2=C(C=CC(=O)O2)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5169","2,6-Dihydroxyanthraquinone","e5","L3000-22","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","2,6-Dihydroxyanthraquinone (Anthraflavic acid, Anthraflavin) is a potent and specific inhibitor of cytochrome P-448 activity.",240.21,"84-60-6",{"v":48,"d":"48.00"},199.83,"N/A","N/A","http://selleckchem.com/products/2-6-dihydroxyanthraquinone.html","C14H8O4","free base","Anthraflavic acid, Anthraflavin","OC1=CC2=C(C=C1)C(=O)C3=CC(=CC=C3C2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S5171","Atrazine","f5","L3000-22","in 10mM DMSO","AP-1","Metabolism","Atrazine (Chromozin, Oleogesaprim, Aktikon, Gesaprim) is a selective triazine herbicide. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations.",215.68,"1912-24-9",{"v":43,"d":"43.00"},199.37,"N/A","N/A","http://selleckchem.com/products/atrazine.html","C8H14ClN5","free base","Chromozin, Oleogesaprim, Aktikon, Gesaprim","CCNC1=NC(=NC(=N1)Cl)NC(C)C",{"v":0,"d":"0.000"},0,0,0]
["S5177","Naproxen","g5","L3000-22","in 10mM DMSO","COX","Immunology & Inflammation","Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.",230.26,"22204-53-1",{"v":46,"d":"46.00"},199.77,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/naproxen.html","C14H14O3","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(O)=O",2.849,2,0,3]
["S5200","Diaveridine","h5","L3000-22","in 10mM DMSO","DHFR","Metabolism","Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.",260.29,"5355-16-8",{"v":25,"d":"25.00"},96.05,"N/A","N/A","http://selleckchem.com/products/diaveridine.html","C13H16N4O2","free base","AI3-23935, CCRIS-3784","COC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1",1.559,4,2,4]
["S5202","Quinocetone","a6","L3000-22","in 10mM DMSO","Bacterial","Microbiology","Quinocetone is a novel veterinary chemicals that is also bacteriocide and potential anti-tumor agent.",306.32,"81810-66-4",{"v":40,"d":"40.00"},130.58,"N/A","N/A","http://selleckchem.com/products/quinocetone.html","C18H14N2O3","free base","N/A","CC1=[N+]([O-])C2=C(C=CC=C2)[N+](=C1C(=O)/C=C/C3=CC=CC=C3)[O-]",2.189,1,0,3]
["S5205","Nilotinib hydrochloride","b6","L3000-22","in 10mM DMSO","Bcr-Abl","Angiogenesis","Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.",565.98,"923288-95-3",{"v":100,"d":"100.00"},176.69,{"v":-1,"d":"-1.00"},-1.77,"http://selleckchem.com/products/nilotinib-hydrochloride.html","C28H22F3N7O.HCl","hydrochloride","AMN-107 HCl","Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",5.466,5,2,7]
["S5209","Enoxacin Sesquihydrate","c6","L3000-22","in 10mM DMSO","Bacterial","Microbiology","Enoxacin sesquihydrate (Enoxacin hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.",347.34,"84294-96-2",{"v":4,"d":"4.00"},11.52,"N/A","N/A","http://selleckchem.com/products/enoxacin-sesquihydrate.html","C15H17FN4O3.3/2H2O","sesquihydrate","Enoxacin hydrate","CCN1C=C(C(O)=O)C(=O)C2=C1N=C(N3CCNCC3)C(=C2)F",-0.749,3,1,3]
["S5210","Sulfamethazine Sodium Salt","d6","L3000-22","in 10mM DMSO","Anti-infection","Microbiology","Sulfamethazine (Sulfadimethyldiazine) is a sulfanilamide anti-infective agent used in the lifestock industry.",300.31,"1981-58-4",{"v":60,"d":"60.00"},199.79,"N/A","N/A","http://selleckchem.com/products/sulfamethazine-sodium-salt.html","C12H13N4O2S.Na","sodium salt","Sulfadimethyldiazine Sodium Salt","CC1=CC(=NC(=N1)N([Na])[S](=O)(=O)C2=CC=C(N)C=C2)C",0.982,4,1,3]
["S5211","4-Aminosalicylic acid","e6","L3000-22","in 10mM DMSO","Bacterial","Microbiology","4-Aminosalicylic acid (Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate) is an antitubercular agent with bacteriostatic activity against Mycobacterium tuberculosis.",153.14,"65-49-6",{"v":10,"d":"10.00"},{"v":65.3,"d":"65.30"},"N/A","N/A","http://selleckchem.com/products/4-aminosalicylic-acid.html","C7H7NO3","free base","Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate","NC1=CC(=C(C=C1)C(O)=O)O",0.471,1,2,1]
["S5233","Fenretinide (NSC 374551)","f6","L3000-22","in 10mM DMSO","Retinoid Receptor","Metabolism","Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.",391.55,"65646-68-6",{"v":78,"d":"78.00"},199.21,"<1","N/A","http://selleckchem.com/products/fenretinide.html","C26H33NO2","free base","4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(=O)NC2=CC=C(O)C=C2)C(C)(C)CCC1",6.463,1,2,6]
["S5234","Nintedanib Ethanesulfonate Salt","g6","L3000-22","in 10mM DMSO","FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.",649.76,"656247-18-6",{"v":100,"d":"100.00"},{"v":153.9,"d":"153.90"},{"v":100,"d":"100.00"},{"v":153.9,"d":"153.90"},"http://selleckchem.com/products/nintedanib-ethanesulfonate-salt.html","C31H33N5O4.C2H6O3S","ethanesulfonate","Intedanib, BIBF 1120","CC[S](O)(=O)=O.COC(=O)C1=CC2=C(C=C1)C(/C(=O)N2)=C(NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(C)CC4)\\C5=CC=CC=C5",{"v":2.9,"d":"2.900"},4,2,9]
["S5240","Lenvatinib (E7080) Mesylate","h6","L3000-22","in 10mM DMSO","c-Kit,c-RET,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Lenvatinib Mesylate (E7080) is a synthetic, orally available tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet-derived growth factor receptor α (PDGFRα), stem cell factor receptor (Kit (c-Kit)), and rearranged during transfection (RET (c-RET)). Lenvatinib Mesylate has potential antineoplastic activity.",522.96,"857890-39-2",{"v":39,"d":"39.00"},74.58,{"v":-1,"d":"-1.00"},-1.91,"http://selleckchem.com/products/lenvatinib-mesylate.html","C21H19ClN4O4.CH4O3S","Mesylate","E7080 mesylate","COC1=C(C=C2C(=CC=NC2=C1)OC3=CC(=C(NC(=O)NC4CC4)C=C3)Cl)C(N)=O.C[S](O)(=O)=O",2.418,5,3,6]
["S5241","Lapatinib ditosylate monohydrate","a7","L3000-22","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate)is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.",943.48,"388082-78-8",{"v":100,"d":"100.00"},105.99,{"v":-1,"d":"-1.00"},-1.06,"https://www.selleckchem.com/products/lapatinib-ditosylate-monohydrate.html","C43H44ClFN4O11S3","ditosylate monohydrate","Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate","O.CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC5=C(C=C4)N=CN=C5NC6=CC(=C(OCC7=CC(=CC=C7)F)C=C6)Cl",9.132,6,2,13]
["S5242","Cediranib Maleate","b7","L3000-22","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Cediranib Maleate (AZD-2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.",566.58,"857036-77-2",{"v":100,"d":"100.00"},{"v":176.5,"d":"176.50"},"<1","N/A","http://selleckchem.com/products/cediranib-maleate.html","C25H27FN4O3.C4H4O4","maleate","AZD-2171 maleate","COC1=CC2=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)N=CN=C2C=C1OCCCN5CCCC5.OC(=O)\\C=C/C(O)=O",1.765,7,1,10]
["S5243","Ruxolitinib Phosphate","c7","L3000-22","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",404.36,"1092939-17-7",{"v":80,"d":"80.00"},197.84,{"v":29,"d":"29.00"},71.72,"http://selleckchem.com/products/ruxolitinib-phosphate.html","C17H18N6.H3O4P","phosphate","INCB018424, INC424","O[P](O)(O)=O.N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",2.412,3,1,4]
["S5247","Selamectin","d7","L3000-22","in 10mM DMSO","Parasite","Microbiology","Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a  wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.",769.96,"220119-17-5",{"v":100,"d":"100.00"},129.88,"N/A","N/A","https://www.selleckchem.com/products/selamectin.html","C43H63NO11","free base","UK-124114","COC1CC(OC(C)C1O)OC/2C(C)\\C=C\\C=C\\3COC4/C(=N/O)C(=CC(C(=O)OC5CC(C\\C=C2C)OC6(CCC(C)C(O6)C7CCCCC7)C5)C34O)C",5.315,9,1,4]
["S5253","Cisapride (R 51619)","e7","L3000-22","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.",465.95,"81098-60-4",{"v":93,"d":"93.00"},199.59,"<1","N/A","http://selleckchem.com/products/cisapride.html","C23H29ClFN3O4","Benzamide","Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid","COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C3=C(OC)C=C(N)C(=C3)Cl",2.785,4,2,9]
["S5254","Dasatinib hydrochloride","f7","L3000-22","in 10mM DMSO","Bcr-Abl,kit,Src","Angiogenesis","Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.",524.47,"854001-07-3",{"v":100,"d":"100.00"},190.67,{"v":11,"d":"11.00"},20.97,"https://www.selleckchem.com/products/dasatinib-hydrochloride.html","C22H27Cl2N7O2S","hydrochloride","BMS-354825 HCl","Cl.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.821,4,3,7]
["S5256","Benproperine phosphate","g7","L3000-22","in 10mM DMSO","Actin,Microtubule Associated","Cytoskeletal Signaling","Benproperine phosphate (Blascorid, Pirexyl), a cough suppressant, is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate suppresses cancer cell migration and tumor metastasis.",407.44,"19428-14-9",{"v":60,"d":"60.00"},147.26,{"v":81,"d":"81.00"},{"v":198.8,"d":"198.80"},"http://selleckchem.com/products/benproperine-phosphate.html","C21H27NO.H3O4P","phosphate","Blascorid, Pirexyl phosphate","CC(COC1=C(CC2=CC=CC=C2)C=CC=C1)N3CCCCC3.O[P](O)(O)=O",4.753,1,0,6]
["S5262","UNC-926","h7","L3000-22","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","UNC-926 is a L3MBTL1 domain inhibitor with Kd value of 3.9 μM for binding with the MBT domain of the L3MBTL1 protein.",337.25,"1184136-10-4",{"v":67,"d":"67.00"},198.67,"<1","N/A","http://selleckchem.com/products/unc-926.html","C16H21BrN2O","free base","N/A","BrC1=CC=CC(=C1)C(=O)N2CCC(CC2)N3CCCC3",2.564,1,0,2]
["S5265","TBB","a8","L3000-22","in 10mM DMSO","Casein Kinase","Metabolism","TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.",434.71,"17374-26-4",{"v":86,"d":"86.00"},197.83,{"v":-1,"d":"-1.00"},{"v":-2.3,"d":"-2.30"},"http://selleckchem.com/products/tbb.html","C6HBr4N3","Benzotriazoles","4,5,6,7-tetrabromobenzotriazole","BrC1=C(Br)C2=C(N=N[NH]2)C(=C1Br)Br",4.428,2,1,0]
["S5269","J147","b8","L3000-22","in 10mM DMSO","MAO","Neuronal Signaling","J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.",350.33,"1146963-51-0",{"v":70,"d":"70.00"},199.81,"N/A","N/A","http://selleckchem.com/products/j147.html","C18H17F3N2O2","free base","N/A","COC1=CC(=CC=C1)/C=N/N(C(=O)C(F)(F)F)C2=CC=C(C)C=C2C",4.845,3,0,5]
["S5271","Suloctidil","c8","L3000-22","in 10mM DMSO","Fungal","Microbiology","Suloctidil, a sulfur-containing aminoalcohol showing to inhibit human platelet aggregation, is a peripheral vasodilator and a potential antifungal agent.",337.56,"54767-75-8",{"v":67,"d":"67.00"},198.48,"N/A","N/A","http://selleckchem.com/products/suloctidil.html","C20H35NOS","free base","N/A","CCCCCCCCNC(C)C(O)C1=CC=C(SC(C)C)C=C1",5.656,0,2,12]
["S5273","Canrenone","d8","L3000-22","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.",340.46,"976-71-6",{"v":68,"d":"68.00"},199.73,"N/A","N/A","http://selleckchem.com/products/canrenone.html","C22H28O3","free base","Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone","CC12CCC(=O)C=C1C=CC3C2CCC4(C)C3CCC45CCC(=O)O5",3.519,3,0,0]
["S5278","Tedizolid (TR-700)","e8","L3000-22","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Tedizolid(TR-700) is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.",370.34,"856866-72-3",{"v":10,"d":"10.00"},{"v":27,"d":"27.00"},{"v":-1,"d":"-1.00"},{"v":-2.7,"d":"-2.70"},"https://www.selleckchem.com/products/tedizolid.html","C17H15FN6O3","Oxazolidinone","N/A","C[N]1N=NC(=N1)C2=CC=C(C=N2)C3=C(F)C=C(C=C3)N4CC(CO)OC4=O",1.784,6,1,4]
["S5279","Fendiline hydrochloride","f8","L3000-22","in 10mM DMSO","Calcium Channel,Ras","Transmembrane Transporters","Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.",351.91,"13636-18-5",{"v":70,"d":"70.00"},198.91,"N/A","N/A","http://selleckchem.com/products/fendiline-hydrochloride.html","C23H25N.HCl","hydrochloride","N/A","Cl.CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3",5.772,0,1,7]
["S5281","Dapiprazole Hydrochloride","g8","L3000-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Dapiprazole Hydrochloride (Glamidolo Hydrochloride, Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole, an alpha-adrenergic blocker used to reverse mydriasis after eye examination.",361.91,"72822-13-0",{"v":21,"d":"21.00"},58.03,{"v":72,"d":"72.00"},198.94,"http://selleckchem.com/products/dapiprazole-hydrochloride.html","C19H27N5.HCl","hydrochloride","Glamidolo Hydrochloride, Reversil Hydrochloride","Cl.CC1=C(C=CC=C1)N2CCN(CC2)CCC3=NN=C4CCCC[N]34",3.384,2,0,4]
["S5284","Adenosine 5'-monophosphate monohydrate","h8","L3000-22","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).",365.24,"18422-05-4",{"v":9,"d":"9.00"},24.64,"N/A","N/A","http://selleckchem.com/products/adenosine-5-monophosphate-monohydrate.html","C10H14N5O7P.H2O","hydrate","5'-Adenylic acid, 5'-AMP","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O",{"v":-2.16,"d":"-2.160"},5,3,4]
["S5285","RU58841","a9","L3000-22","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen.",369.34,"154992-24-2",{"v":73,"d":"73.00"},197.65,"<1","N/A","http://selleckchem.com/products/ru58841.html","C17H18F3N3O3","free base","PSK3841, HMR3841","CC1(C)N(CCCCO)C(=O)N(C1=O)C2=CC=C(C#N)C(=C2)C(F)(F)F",2.548,2,1,6]
["S5286","Ramatroban","b9","L3000-22","in 10mM DMSO","Prostaglandin Receptor","Metabolism","Ramatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells.",416.47,"116649-85-5",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/ramatroban.html","C21H21FN2O4S","free base","BAY u 3405","OC(=O)CC[N]1C2=C(CC(CC2)N[S](=O)(=O)C3=CC=C(F)C=C3)C4=CC=CC=C14",{"v":3.51,"d":"3.510"},3,1,6]
["S5288","Estropipate","c9","L3000-22","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estropipate (Piperazine estrone sulfate, Estrone sulfate piperazine salt, Pipestrone) is a natural estrogenic substance composed of estrone sulfate and piperazine and is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms.",436.56,"7280-37-7",{"v":87,"d":"87.00"},199.28,{"v":-1,"d":"-1.00"},-2.29,"https://www.selleckchem.com/products/estropipate.html","C22H32N2O5S","Estrogen","Piperazine estrone sulfate, Estrone sulfate piperazine salt, Pipestrone","CC12CCC3C(CCC4=C3C=CC(=C4)O[S](O)(=O)=O)C1CCC2=O.C5CNCCN5",2.751,2,2,2]
["S5293","Nimustine Hydrochloride","d9","L3000-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.",309.15,"55661-38-6",{"v":61,"d":"61.00"},197.32,"N/A","N/A","http://selleckchem.com/products/nimustine-hydrochloride.html","C9H13ClN6O2.HCl","hydrochloride","Nidran hydrochloride","Cl.CC1=NC=C(CNC(=O)N(CCCl)N=O)C(=N1)N",{"v":0.47,"d":"0.470"},4,2,5]
["S5297","Vidarabine monohydrate","e9","L3000-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.",285.26,"24356-66-9",{"v":57,"d":"57.00"},199.82,"N/A","N/A","http://selleckchem.com/products/vidarabine-monohydrate.html","C10H13N5O4.H2O","hydrate","Spongoadenosine monohydrate, Vira-A monohydrate","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-2.088,4,4,2]
["S5298","Amoxicillin trihydrate","f9","L3000-22","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.",419.45,"61336-70-7",{"v":30,"d":"30.00"},71.52,"N/A","N/A","http://selleckchem.com/products/amoxicillin-trihydrate.html","C16H19N3O5S.3H2O","trihydrate","Amoxil trihydrate, Amoxipen trihydrate, Moxaline trihydrate","O.O.O.CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O",-3.161,3,3,4]
["S5301","Carglumic Acid","g9","L3000-22","in 10mM DMSO","CPSase","Metabolism","Carglumic Acid (arbamylglutamic acid, Carbamino-L-glutamic acid, Ureidoglutaric acid, N-Carbamylglutamate) is an orally active, synthetic structural analogue of N-acetylglutamate (NAG) and carbamoyl phosphate synthetase 1 (CPS 1) activator, with ammonia lowering activity.",190.15,"1188-38-1",{"v":38,"d":"38.00"},199.84,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/carglumic-acid.html","C6H10N2O5","Free Base","Carbamylglutamic acid, Carbamino-L-glutamic acid, Ureidoglutaric acid, N-Carbamylglutamate","NC(=O)NC(CCC(O)=O)C(O)=O",-1.169,3,2,5]
["S5303","Afalanine (N-Acetyl-DL-phenylalanine)","h9","L3000-22","in 10mM DMSO","Others","Others","Afalanine (N-Acetyl-DL-phenylalanine, Afalanine) acts as an antidepressant and a metabolite.",207.23,"2901-75-9",{"v":41,"d":"41.00"},197.85,{"v":-1,"d":"-1.00"},-4.83,"https://www.selleckchem.com/products/n-acetyl-dl-phenylalanine.html","C11H13NO3","Amino acid","Afalanine","CC(=O)NC(CC1=CC=CC=C1)C(O)=O",0.895,2,1,4]
["S5304","2-Acetylphenothiazine (ML171)","a10","L3000-22","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.",241.31,"6631-94-3",{"v":48,"d":"48.00"},198.91,"N/A","N/A","http://selleckchem.com/products/2-acetylphenothiazine-ml171.html","C14H11NOS","free base","2-APT","CC(=O)C1=CC=C2SC3=C(NC2=C1)C=CC=C3",3.408,1,1,1]
["S5306","Forchlorfenuron (CPPU)","b10","L3000-22","in 10mM DMSO","Others","Cytoskeletal Signaling","Forchlorfenuron (CPPU) is a synthetic cytokinin that inhibits septins and exhibits anti-parasitic, anticancer, and anti-angiogenic activities.",247.68,"68157-60-8",{"v":49,"d":"49.00"},197.84,"N/A","N/A","http://selleckchem.com/products/forchlorfenuron.html","C12H10ClN3O","free base","KT-30","ClC1=NC=CC(=C1)NC(=O)NC2=CC=CC=C2",2.245,2,2,2]
["S5308","7-(Diethylamino)coumarin-3-carboxylic acid","c10","L3000-22","in 10mM DMSO","Others","Others","7-(Diethylamino)-coumarin-3-carboxylic acid (7-DCCA) has been used as a laser dye, fluorescent label, and biomedical inhibitor in many different applications.",261.27,"50995-74-9",{"v":52,"d":"52.00"},199.03,"<1","N/A","http://selleckchem.com/products/7-diethylamino-coumarin-3-carboxylic-acid.html","C14H15NO4","free base","7-DCCA","CCN(CC)C1=CC2=C(C=C1)C=C(C(O)=O)C(=O)O2",2.349,3,0,4]
["S5310","4,4'-Dimethoxybenzil","d10","L3000-22","in 10mM DMSO","Others","Others","4,4'-Dimethoxybenzil (p-Anisil) is a biochemical that has been reported to have mesomorphic properties of a substituted bis(dithiolene)nickel complex derived from 4,4′-dimethoxybenzil.",270.28,"1226-42-2",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/dimethoxybenzil.html","C16H14O4","free base","p-Anisil","COC1=CC=C(C=C1)C(=O)C(=O)C2=CC=C(OC)C=C2",3.087,4,0,5]
["S5312","Urolithin A","e10","L3000-22","in 10mM DMSO","Mitophagy","Autophagy","Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.",{"v":228.2,"d":"228.20"},"1143-70-0",{"v":45,"d":"45.00"},{"v":197.2,"d":"197.20"},"<1","N/A","http://selleckchem.com/products/urolithin-a.html","C13H8O4","free base","3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin","OC1=CC=C2C(=C1)OC(=O)C3=CC(=CC=C23)O",2.466,2,2,0]
["S5313","SC66","f10","L3000-22","in 10mM DMSO","Akt","PI3K/Akt/mTOR","SC66 is an allosteric inhibitor which displays a dual-inhibitory function toward AKT activity with IC50 values of 0.77, 2.85 and 0.47 μg/ml in HepG2, Huh7 and Hep3B cells after 72 h treatment, respectively.",276.33,"871361-88-5",{"v":55,"d":"55.00"},199.04,"N/A","N/A","http://selleckchem.com/products/sc66.html","C18H16N2O","free base","N/A","O=C1C(/CCC\\C1=C/C2=CC=NC=C2)=C/C3=CC=NC=C3",2.836,3,0,2]
["S5314","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","g10","L3000-22","in 10mM DMSO","ROS","Immunology & Inflammation","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS), including peroxyl radicals, and scavenging them to form more stable free radicals.",236.35,"148081-72-5",{"v":47,"d":"47.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hthq-1-o-hexyl-2-3-5-trimethylhydroquinone.html","C15H24O2","Hydroquinones","N/A","CCCCCCOC1=CC(=C(O)C(=C1C)C)C",5.271,1,1,6]
["S5315","PRT4165","h10","L3000-22","in 10mM DMSO","BMI-1,E3 Ligase","Ubiquitin","PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.",235.24,"31083-55-3",{"v":11,"d":"11.00"},46.76,"<1","N/A","http://selleckchem.com/products/prt4165.html","C15H9NO2","free base","N/A","O=C1C2=C(C=CC=C2)C(=O)C1=CC3=CC=CN=C3",2.085,3,0,1]
["S5316","NU2058","a11","L3000-22","in 10mM DMSO","CDK","Cell Cycle","NU2058 (O(6)-Cyclohexylmethylguanine) is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.",{"v":247.3,"d":"247.30"},"161058-83-9",{"v":49,"d":"49.00"},198.14,"<1","N/A","http://selleckchem.com/products/nu2058.html","C12H17N5O","free base","O(6)-Cyclohexylmethylguanine","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3CCCCC3",2.251,4,2,3]
["S5317","UK 5099","b11","L3000-22","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier, inhibiting pyruvate transport across the plasma membrane of trypanosomes with Ki value of 49 μM.",{"v":288.3,"d":"288.30"},"56396-35-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/uk5099.html","C18H12N2O2","Mitochondrial pyruvate carrier","PF-1005023","OC(=O)\\C(=C\\C1=C[N](C2=CC=CC=C2)C3=C1C=CC=C3)C#N",3.842,1,0,3]
["S5318","Acacetin","c11","L3000-22","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.",284.26,"480-44-4",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"N/A","N/A","http://selleckchem.com/products/acacetin.html","C16H12O5","free base","Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",2.636,3,2,2]
["S5319","Imepitoin","d11","L3000-22","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Imepitoin(ELB-138,AWD 131-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.  AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.",279.72,"188116-07-6",{"v":30,"d":"30.00"},107.25,"<1","N/A","http://selleckchem.com/products/awd-131-138.html","C13H14ClN3O2","free base","ELB-138,AWD 131-138","ClC1=CC=C(C=C1)N2CC(=NC2=O)N3CCOCC3",{"v":1.44,"d":"1.440"},3,0,2]
["S5321","Y15","e11","L3000-22","in 10mM DMSO","FAK","Angiogenesis","Y15 (1,2,4,5-Benzenetetraamine tetrahydrochloride, FAK inhibitor 14) is a small-molecule FAK scaffolding inhibitor that directly inhibits FAK autophosphorylation in a dose- and time-dependent manner.",284.01,"4506-66-5",{"v":56,"d":"56.00"},197.18,{"v":56,"d":"56.00"},197.18,"http://selleckchem.com/products/y15.html","C6H10N4.4HCl","tetrahydrochloride","1,2,4,5-Benzenetetraamine tetrahydrochloride, FAK inhibitor 14","Cl.Cl.Cl.Cl.NC1=CC(=C(N)C=C1N)N",0.371,0,4,0]
["S5325","Nitisinone","f11","L3000-22","in 10mM DMSO","Others","Metabolism","Nitisinone (NTBC, Nitisone, SC0735) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.",329.23,"104206-65-7",{"v":65,"d":"65.00"},197.43,"<1","N/A","http://selleckchem.com/products/nitisinone.html","C14H10F3NO5","free base","NTBC, Nitisone, SC0735","[O-][N+](=O)C1=CC(=CC=C1C(=O)C2C(=O)CCCC2=O)C(F)(F)F",{"v":2.53,"d":"2.530"},3,0,4]
["S5327","Meisoindigo","g11","L3000-22","in 10mM DMSO","Others","Apoptosis","Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).",276.29,"97207-47-1",{"v":55,"d":"55.00"},199.07,"<1","N/A","http://selleckchem.com/products/meisoindigo.html","C17H12N2O2","free base","N-Methylisoindigotin, Methylisoindigotin, Dian III","CN1C(=O)/C(C2=C1C=CC=C2)=C3/C(=O)NC4=CC=CC=C34",1.851,2,1,0]
["S5341","Metroprolol succinate","h11","L3000-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Metroprolol Succinate (Metoprolol succinate) is the succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity.",652.82,"98418-47-4",{"v":100,"d":"100.00"},153.18,{"v":100,"d":"100.00"},153.18,"http://selleckchem.com/products/metroprolol-succinate.html","C34H56N2O10","succinate","Metoprolol succinate","COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC2=CC=C(OCC(O)CNC(C)C)C=C2.OC(=O)CCC(O)=O",-2.255,6,4,21]
["S5345","(+/-)-nerolidol","a2","L3000-23","in 10mM DMSO","Parasite","Microbiology","(+/-)-nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.",222.37,"7212-44-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/nerolidol.html","C15H26O","free base","Peruviol","CC(C)=CCC/C(C)=C/CCC(C)(O)C=C",4.561,0,0,7]
["S5353","Cefpiramide sodium","b2","L3000-23","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefpiramide sodium (CPMS, SM-1652,wy-44635) is an anionic β-lactam antibiotic. It exhibits antibacterial activity against gram-positive and gram-negative bacteria, in particular, to Pseudomonas aeruginosa, which can result in achronic life-threatening infection in the lungs of cystic fibrosis patients.",634.62,"74849-93-7",{"v":100,"d":"100.00"},157.57,{"v":100,"d":"100.00"},157.57,"http://selleckchem.com/products/cefpiramide-sodium.html","C25H23N8NaO7S2","Cephalosporin","SM-1652, wy-44635","[Na+].C[N]1N=NN=C1SCC2=C(N3C(SC2)C(NC(=O)C(NC(=O)C4=C(O)C=C(C)N=C4)C5=CC=C(O)C=C5)C3=O)C([O-])=O",-1.425,7,4,9]
["S5358","Regadenoson","c2","L3000-23","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Regadenoson (CVT-3146, Lexiscan) is a selective A2A adenosine receptor agonist with coronary vasodilating activity.",390.35,"313348-27-5",{"v":56,"d":"56.00"},143.46,"<1","N/A","http://selleckchem.com/products/regadenoson.html","C15H18N8O5","free base","CVT-3146, Lexiscan","CNC(=O)C1=C[N](N=C1)C2=NC3=C(N=C[N]3C4OC(CO)C(O)C4O)C(=N2)N",-1.925,6,5,4]
["S5364","DY131","d2","L3000-23","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","DY131 is a potent and selective ERRβ/γ activator. It has no effect on the structurally related receptors ERRalpha or the estrogen receptors alpha and beta (ERalpha/beta).",311.38,"95167-41-2",{"v":62,"d":"62.00"},199.11,"<1","N/A","http://selleckchem.com/products/dy131.html","C18H21N3O2","free base","N/A","CCN(CC)C1=CC=C(C=C1)\\C=N\\NC(=O)C2=CC=C(O)C=C2",3.301,2,2,6]
["S5365","Alogliptin","e2","L3000-23","in 10mM DMSO","DPP","Proteases","Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.",339.39,"850649-61-5",{"v":67,"d":"67.00"},197.41,{"v":18,"d":"18.00"},53.04,"http://selleckchem.com/products/alogliptin.html","C18H21N5O2","Dipeptidyl Peptidase-4","SYR 322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S5366","Fipronil","f2","L3000-23","in 10mM DMSO","Anti-infection","Microbiology","Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.",437.15,"120068-37-3",{"v":87,"d":"87.00"},199.02,"N/A","N/A","http://selleckchem.com/products/fipronil.html","C12H4Cl2F6N4OS","free base","Fluocyanobenpyrazole, Termidor","NC1=C(C(=N[N]1C2=C(Cl)C=C(C=C2Cl)C(F)(F)F)C#N)[S](=O)C(F)(F)F",5.579,2,1,4]
["S5369","Ethoxyquin","g2","L3000-23","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Ethoxyquin (Santoquin, Santoflex, Quinol) is an antioxidant used as a food preservative.  Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).",217.31,"91-53-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/ethoxyquin.html","C14H19NO","free base","Santoquin, Santoflex, Quinol","CCOC1=CC2=C(NC(C)(C)C=C2C)C=C1",3.221,1,1,2]
["S5370","10-Hydroxydecanoic acid","h2","L3000-23","in 10mM DMSO","Others","Others","10-Hydroxydecanoic acid, a minor constituent of royal jelly, is a saturated fatty acid that has cytotoxic effects.",188.26,"1679-53-4",{"v":37,"d":"37.00"},196.53,{"v":-1,"d":"-1.00"},-5.31,"https://www.selleckchem.com/products/10-hydroxydecanoic-acid.html","C10H20O3","free base","N/A","OCCCCCCCCCC(O)=O",{"v":2.43,"d":"2.430"},1,1,9]
["S5371","Ajmaline","a3","L3000-23","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.",326.43,"4360-12-7",{"v":65,"d":"65.00"},199.12,{"v":-1,"d":"-1.00"},-3.06,"https://www.selleckchem.com/products/ajmaline.html","C20H26N2O2","free base","Cardiorythmine, Tachmalin","CCC1C(O)N2C3CC1C4C(O)C5(CC24)C3N(C)C6=CC=CC=C56",1.932,0,2,1]
["S5372","Methyl Aminolevulinate Hydrochloride","b3","L3000-23","in 10mM DMSO","Others","Others","Methyl Aminolevulinate (Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride) is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy.",181.62,"79416-27-6",{"v":36,"d":"36.00"},198.22,{"v":-1,"d":"-1.00"},-5.51,"https://www.selleckchem.com/products/methyl-aminolevulinate-hydrochloride.html","C6H12ClNO3","free base","Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride","Cl.COC(=O)CCC(=O)CN",-0.613,3,1,5]
["S5373","Pseudolaric Acid B","c3","L3000-23","in 10mM DMSO","Fungal","Microbiology","Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.",432.46,"82508-31-4",{"v":86,"d":"86.00"},198.86,"<1","N/A","https://www.selleckchem.com/products/pseudolaric-acid-b.html","C23H28O8","Diterpenoids","N/A","COC(=O)C1=CCC23CCC(C(C)(OC2=O)\\C=C\\C=C(C)\\C(O)=O)C3(CC1)OC(C)=O",2.793,7,0,7]
["S5377","Dibutyl phthalate","d3","L3000-23","in 10mM DMSO","Others","Others","Dibutyl phthalate is widely used as plasticizer in numerous kinds of products such as plastic packaging in food industries.",278.34,"84-74-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/dibutyl-phthalate.html","C16H22O4","free base","N/A","CCCCOC(=O)C1=C(C=CC=C1)C(=O)OCCCC",4.198,4,0,10]
["S5387","D-Tagatose","e3","L3000-23","in 10mM DMSO","Others","Others","D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.",180.16,"87-81-0",{"v":36,"d":"36.00"},199.83,{"v":-1,"d":"-1.00"},-5.55,"https://www.selleckchem.com/products/d-tagatose.html","C6H12O6","free base","N/A","OCC(O)C(O)C(O)C(=O)CO",-2.874,1,5,5]
["S5392","Mepivacaine","f3","L3000-23","in 10mM DMSO","Others","Others","Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia.",246.35,"96-88-8",{"v":49,"d":"49.00"},198.91,{"v":-1,"d":"-1.00"},-4.06,"https://www.selleckchem.com/products/mepivacaine.html","C15H22N2O","free base","Carbocaine","CN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",2.981,1,1,2]
["S5394","Tizoxanide","g3","L3000-23","in 10mM DMSO","HCV Protease","Microbiology","Tizoxanide (Desacetyl-nitazoxanide), a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C.",265.25,"173903-47-4",{"v":27,"d":"27.00"},101.79,"<1","N/A","http://selleckchem.com/products/tizoxanide.html","C10H7N3O4S","free base","Desacetyl-nitazoxanide","OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.388,2,2,3]
["S5398","Nefazodone hydrochloride","h3","L3000-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Nefazodone hydrochloride (BMY-13754-1) is the hydrochloride salt form of nefazodone, which is an atypical antidepressant showing antagonistic activity on serotonin reuptake.",506.47,"82752-99-6",{"v":22,"d":"22.00"},43.44,{"v":-1,"d":"-1.00"},-1.97,"https://www.selleckchem.com/products/nefazodone-hydrochloride.html","C25H33Cl2N5O2","free base","BMY-13754-1","Cl.CCC1=NN(CCCN2CCN(CC2)C3=CC(=CC=C3)Cl)C(=O)N1CCOC4=CC=CC=C4",4.797,3,0,10]
["S5399","Chlorprothixene hydrochloride","a4","L3000-23","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Chlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the  hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.",352.32,"6469-93-8",{"v":70,"d":"70.00"},198.68,{"v":-1,"d":"-1.00"},-2.84,"https://www.selleckchem.com/products/chlorprothixene-hydrochloride.html","C18H19Cl2NS","free base","Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193","Cl.CN(C)CC\\C=C/1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",5.505,0,0,3]
["S5401","Tegaserod Maleate","b4","L3000-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tegaserod Maleate(HTF-919) is a hydrogen maleate salt form of tegaserod, which is a 5-HT4 receptor partial agonist and binds with high affinity to 5-HT4 receptors. It has limited affinity for 5-HT1 receptors and no appreciable affinity for other 5-HT receptors, muscarinic, adrenergic, dopaminergic or opiate receptors.",417.46,"189188-57-6",{"v":83,"d":"83.00"},198.82,"<1","N/A","http://selleckchem.com/products/tegaserod-maleate.html","C16H23N5O.C4H4O4","maleate","HTF-919","CCCCCNC(=N)N/N=C/C1=C[NH]C2=C1C=C(OC)C=C2.OC(=O)\\C=C/C(O)=O",{"v":3.17,"d":"3.170"},4,3,11]
["S5416","Metyrapone","c4","L3000-23","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.",226.27,"54-36-4",{"v":46,"d":"46.00"},203.29,{"v":-1,"d":"-1.00"},-4.42,"https://www.selleckchem.com/products/metyrapone.html","C14H14N2O","free base","NSC-25265, SU-4885","CC(C)(C1=CC=CN=C1)C(=O)C2=CC=CN=C2",1.847,3,0,3]
["S5418","Parecoxib Sodium","d4","L3000-23","in 10mM DMSO","COX","Immunology & Inflammation","Parecoxib Sodium (SC-69124) is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).",{"v":392.4,"d":"392.40"},"198470-85-8",{"v":78,"d":"78.00"},198.77,{"v":-1,"d":"-1.00"},-2.55,"https://www.selleckchem.com/products/parecoxib-sodium.html","C19H17N2NaO4S","free base","SC-69124 Sodium","CCC(=O)N([Na])[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",{"v":3.36,"d":"3.360"},5,0,5]
["S5419","1,4-Cineole","e4","L3000-23","in 10mM DMSO","TRP Channel","Transmembrane Transporters","1,4-Cineole (Isocineole) is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.",154.25,"470-67-7",{"v":30,"d":"30.00"},194.49,"N/A","N/A","http://selleckchem.com/products/1-4-cineole.html","C10H18O","free base","Isocineole","CC(C)C12CCC(C)(CC1)O2",2.282,1,0,1]
["S5424","Carbaryl","f4","L3000-23","in 10mM DMSO","AChR","Neuronal Signaling","Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide and also a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors.",201.22,"63-25-2",{"v":40,"d":"40.00"},198.79,"N/A","N/A","http://selleckchem.com/products/carbaryl.html","C12H11NO2","free base","1-naphthyl methylcarbamate","CNC(=O)OC1=C2C=CC=CC2=CC=C1",2.502,2,1,2]
["S5426","Bromopyruvic acid","g4","L3000-23","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.",166.96,"1113-59-3",{"v":33,"d":"33.00"},197.65,"N/A","N/A","http://selleckchem.com/products/bromopyruvic-acid.html","C3H3BrO3","free base","3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP","OC(=O)C(=O)CBr",0.348,2,0,2]
["S5428","Promazine hydrochloride","h4","L3000-23","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.",320.88,"53-60-1",{"v":64,"d":"64.00"},199.45,"N/A","N/A","http://selleckchem.com/products/promazine-hydrochloride.html","C17H20N2S.HCl","hydrochloride","Romtiazin hydrochloride, Sinophenin hydrochloride","Cl.CN(C)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3",4.457,0,0,4]
["S5435","Quinacrine Dihydrochloride Dihydrate","a5","L3000-23","in 10mM DMSO","Others","Others","Quinacrine (Mepacrine) is a dye of the acridine family that has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug.",508.91,"6151-30-0",{"v":10,"d":"10.00"},19.65,"N/A","N/A","http://selleckchem.com/products/quinacrine-dihydrochloride-dihydrate.html","C23H30ClN3O.2HCl.2H2O","dihydrochloride, dihydrate","Mepacrine Dihydrochloride Dihydrate","O.O.Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",6.015,2,1,9]
["S5447","Triprolidine Hydrochloride","b5","L3000-23","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Triprolidine Hydrochloride is the hydrochloride salt form of Triprolidine, which is the first generation histamine H1 antagonist used in allergic rhinitis.",332.87,"6138-79-0",{"v":62,"d":"62.00"},186.26,"N/A","N/A","http://selleckchem.com/products/triprolidine-hydrochloride.html","C19H22N2.HCl.H2O","hydrochloride, hydrate","N/A","O.Cl.CC1=CC=C(C=C1)\\C(=C/CN2CCCC2)C3=NC=CC=C3",4.249,1,0,4]
["S5451","Ferulic acid methyl ester","c5","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid,  which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.",208.21,"2309-07-1",{"v":41,"d":"41.00"},196.92,{"v":41,"d":"41.00"},196.92,"http://selleckchem.com/products/ferulic-acid-methylester.html","C11H12O4","free base","Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate","COC(=O)\\C=C\\C1=CC=C(O)C(=C1)OC",1.894,3,1,4]
["S5452","Sanguinarine chloride","d5","L3000-23","in 10mM DMSO","phosphatase,ROS","Immunology & Inflammation","Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.",367.78,"5578-73-4",{"v":5,"d":"5.00"},{"v":13.6,"d":"13.60"},"<1","N/A","http://selleckchem.com/products/sanguinarine-chloride.html","C20H14NO4.Cl","chloride","N/A","[Cl-].C[N+]1=CC2=C3OCOC3=CC=C2C4=CC=C5C=C6OCOC6=CC5=C14",1.313,4,0,0]
["S5453","Hyperoside","e5","L3000-23","in 10mM DMSO","NF-κB","NF-κB","Hyperoside (Hyperin, Quercetin 3-galactoside), a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.Hyperoside can inhibit activation of the NF-κB signaling pathway.",464.38,"482-36-0",{"v":92,"d":"92.00"},198.11,{"v":1,"d":"1.00"},2.15,"http://selleckchem.com/products/hyperoside.html","C21H20O12","free base","Hyperin, Quercetin 3-galactoside","OCC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S5454","Saikosaponin D","f5","L3000-23","in 10mM DMSO","ATPase","Transmembrane Transporters","Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.",780.98,"20874-52-6",{"v":100,"d":"100.00"},128.04,"<1","N/A","http://selleckchem.com/products/saikosaponin-d.html","C42H68O13","free base","N/A","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O",1.107,5,8,6]
["S5456","Isobavachalcone","g5","L3000-23","in 10mM DMSO","Bacterial","Microbiology","Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.",324.37,"20784-50-3",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/isobavachalcone.html","C20H20O4","free base","Corylifolinin","CC(C)=CCC1=C(O)C(=CC=C1O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.832,1,3,5]
["S5457","Curculigoside","h5","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Curculigoside (Curculigoside A), a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.",466.44,"85643-19-2",{"v":93,"d":"93.00"},199.38,{"v":15,"d":"15.00"},32.16,"http://selleckchem.com/products/curculigoside.html","C22H26O11","free base","Curculigoside A","COC1=C(C(=O)OCC2=CC(=CC=C2OC3OC(CO)C(O)C(O)C3O)O)C(=CC=C1)OC",0.822,6,5,9]
["S5458","Verbascoside","a6","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.",624.59,"61276-17-3",{"v":100,"d":"100.00"},160.11,{"v":100,"d":"100.00"},160.11,"http://selleckchem.com/products/verbascoside.html","C29H36O15","free base","Acteoside, Kusaginin","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(CO)C2OC(=O)\\C=C\\C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",0.484,6,9,11]
["S5459","Aucubin","b6","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.",346.33,"479-98-1",{"v":69,"d":"69.00"},199.23,{"v":15,"d":"15.00"},43.31,"http://selleckchem.com/products/aucubin.html","C15H22O9","free base","Rhinanthin","OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O",-2.916,3,6,4]
["S5463","Curcurbitacin IIA","c6","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.",562.73,"58546-34-2",{"v":100,"d":"100.00"},177.71,"<1","N/A","http://selleckchem.com/products/curcurbitacin-iia.html","C32H50O8","free base","Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1","CC(=O)OC(C)(C)CCC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(O)C4(C)C)C3(C)C(=O)CC12C",{"v":1.92,"d":"1.920"},4,3,7]
["S5464","Psoralidin","d6","L3000-23","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.",336.34,"18642-23-4",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/psoralidin.html","C20H16O5","free base","N/A","CC(C)=CCC1=CC2=C(OC(=O)C3=C2OC4=C3C=CC(=C4)O)C=C1O",4.917,3,2,2]
["S5466","Saikosaponin A","e6","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.",780.98,"20736-09-8",{"v":100,"d":"100.00"},128.04,"<1","N/A","https://www.selleckchem.com/products/saikosaponin-a.html","C42H68O13","free base","N/A","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O",1.107,5,8,6]
["S5469","Bavachin","f6","L3000-23","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bavachin (Corylifolin) is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. It acts as a weak phytoestrogen by binding and activating the ER.",324.37,"19879-32-4",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/bavachin.html","C20H20O4","free base","Corylifolin","CC(C)=CCC1=CC2=C(OC(CC2=O)C3=CC=C(O)C=C3)C=C1O",4.472,2,2,3]
["S5471","Monotropein","g6","L3000-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.",390.34,"5945-50-6",{"v":78,"d":"78.00"},199.83,{"v":78,"d":"78.00"},199.83,"http://selleckchem.com/products/monotropein.html","C16H22O11","free base","N/A","OCC1OC(OC2OC=C(C3C=CC(O)(CO)C23)C(O)=O)C(O)C(O)C1O",-3.201,4,5,5]
["S5472","Nafronyl oxalate salt","h6","L3000-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Nafronyl oxalate salt is the oxalate salt form of nafronyl, which is a selective antagonist of 5-HT2 receptors and a vasodilator used in the management of peripheral and cerebral vascular disorders.",473.56,"3200-06-4",{"v":94,"d":"94.00"},{"v":198.5,"d":"198.50"},{"v":94,"d":"94.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/nafronyl-oxalate-salt.html","C24H33NO3.C2H2O4","oxalate","N/A","CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=C3C=CC=CC3=CC=C2.OC(=O)C(O)=O",1.048,5,0,12]
["S5476","Rolapitant","a7","L3000-23","in 10mM DMSO","Neurokinin Receptor","Neuronal Signaling","Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.",500.48,"552292-08-7",{"v":100,"d":"100.00"},199.81,"N/A","N/A","https://www.selleckchem.com/products/rolapitant.html","C25H26F6N2O2","NK1 receptor antagonists","SCH-619734","CC(OCC1(CCC2(CCC(=O)N2)CN1)C3=CC=CC=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",4.761,2,2,7]
["S5479","Cloperastine hydrochloride","b7","L3000-23","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cloperastine (HT-11) is a drug with a central antitussive effect, and is also endowed with an antihistaminic activity.",366.32,"14984-68-0",{"v":73,"d":"73.00"},199.28,"N/A","N/A","http://selleckchem.com/products/cloperastine-hydrochloride.html","C20H24ClNO.HCl","hydrochloride","HT-11 hydrochloride","Cl.ClC1=CC=C(C=C1)C(OCCN2CCCCC2)C3=CC=CC=C3",5.348,1,0,6]
["S5480","Clidinium Bromide","c7","L3000-23","in 10mM DMSO","AChR","Neuronal Signaling","Clidinium Bromide(Ro 2-3773) is an anticholinergic drug.",432.35,"3485-62-9",{"v":86,"d":"86.00"},198.91,"N/A","N/A","http://selleckchem.com/products/clidinium-bromide.html","C22H26NO3.Br","bromide","Ro 2-3773","[Br-].C[N+]12CCC(CC1)C(C2)OC(=O)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",-0.622,2,0,5]
["S5481","Molindone hydrochloride","d7","L3000-23","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.",312.83,"15622-65-8",{"v":9,"d":"9.00"},28.77,"N/A","N/A","http://selleckchem.com/products/molindone-hydrochloride.html","C16H24N2O2.HCl","hydrochloride","N/A","Cl.CCC1=C(C)[NH]C2=C1C(=O)C(CC2)CN3CCOCC3",2.522,2,1,3]
["S5485","Desipramine Hydrochloride","e7","L3000-23","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.",302.84,"58-28-6",{"v":60,"d":"60.00"},198.12,"N/A","N/A","http://selleckchem.com/products/desipramine-hydrochloride.html","C18H22N2.HCl","hydrochloride","Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901","Cl.CNCCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.234,0,1,4]
["S5486","Fluorometholone","f7","L3000-23","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.",376.46,"426-13-1",{"v":75,"d":"75.00"},199.22,"<1","N/A","http://selleckchem.com/products/fluorometholone.html","C22H29FO4","free base","Oxylone","CC1CC2C3CCC(O)(C(C)=O)C3(C)CC(O)C2(F)C4(C)C=CC(=O)C=C14",2.312,2,1,1]
["S5487","Cefoperazone sodium","g7","L3000-23","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefoperazone Sodium(CP 52640-2) is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity.",667.65,"62893-20-3",{"v":100,"d":"100.00"},149.78,{"v":-1,"d":"-1.00"},{"v":-1.5,"d":"-1.50"},"https://www.selleckchem.com/products/cefoperazone-sodium.html","C25H26N9NaO8S2","free base","CP 52640-2","[Na+].CCN1CCN(C(=O)NC(C(=O)NC2C3SCC(=C(N3C2=O)C([O-])=O)CSC4=NN=N[N]4C)C5=CC=C(O)C=C5)C(=O)C1=O",-2.266,8,3,9]
["S5488","Fluorescein","h7","L3000-23","in 10mM DMSO","Dyes","Others","Fluorescein (Solvent Yellow 94, Resorcinolphthalein, Yellow fluorescein) is a manufactured organic compound and dye.",332.31,"2321-07-5",{"v":67,"d":"67.00"},201.62,{"v":-1,"d":"-1.00"},-3.01,"https://www.selleckchem.com/products/fluorescein.html","C20H12O5","free base","Solvent Yellow 94, Resorcinolphthalein, Yellow fluorescein","OC1=CC2=C(C=C1)C3(OC(=O)C4=C3C=CC=C4)C5=C(O2)C=C(O)C=C5",3.737,3,2,0]
["S5490","Disopyramide","a8","L3000-23","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.",339.47,"3737-09-5",{"v":67,"d":"67.00"},197.37,"N/A","N/A","http://selleckchem.com/products/disopyramide.html","C21H29N3O","Antiarrhythmic agent","N/A","CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C2=NC=CC=C2)C(C)C",3.417,2,1,8]
["S5491","Lomefloxacin","b8","L3000-23","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic used to treat bacterial infections.",351.35,"98079-51-7",{"v":7,"d":"7.00"},19.92,{"v":-1,"d":"-1.00"},-2.85,"https://www.selleckchem.com/products/lomefloxacin.html","C17H19F2N3O3","free base","SC47111A","CCN1C=C(C(O)=O)C(=O)C2=C1C(=C(N3CCNC(C)C3)C(=C2)F)F",-0.828,2,1,3]
["S5492","Econazole","c8","L3000-23","in 10mM DMSO","Bacterial","Microbiology","Econazole is a broad spectrum antimycotic with some action against Gram positive bacteria.",381.68,"27220-47-9",{"v":76,"d":"76.00"},199.12,"N/A","N/A","http://selleckchem.com/products/econazole.html","C18H15Cl3N2O","free base","N/A","ClC1=CC=C(COC(C[N]2C=CN=C2)C3=C(Cl)C=C(Cl)C=C3)C=C1",4.981,2,0,6]
["S5493","Atropine sulfate","d8","L3000-23","in 10mM DMSO","AChR","Neuronal Signaling","Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.",676.82,"55-48-1",{"v":18,"d":"18.00"},26.59,"N/A","N/A","https://www.selleckchem.com/products/atropine-sulfate.html","C34H46N2O6.H2SO4","sulfate","Sulfatropinol, Atropette, Tropintran","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.835,4,2,10]
["S5494","Salbutamol","e8","L3000-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.",239.31,"18559-94-9",{"v":47,"d":"47.00"},{"v":196.4,"d":"196.40"},"N/A","N/A","https://www.selleckchem.com/products/salbutamol.html","C13H21NO3","free base","Albuterol","CC(C)(C)NCC(O)C1=CC=C(O)C(=C1)CO",0.941,0,4,5]
["S5498","Betahistine mesylate","f8","L3000-23","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.",328.41,"54856-23-4",{"v":65,"d":"65.00"},197.92,"N/A","N/A","http://selleckchem.com/products/betahistine-mesylate.html","C8H12N2.2CH4O3S","dimethanesulfonate","N/A","CNCCC1=CC=CC=N1.C[S](O)(=O)=O.C[S](O)(=O)=O",-0.148,1,1,3]
["S5502","Ilaprazole sodium","g8","L3000-23","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.",388.42,"172152-50-0",{"v":78,"d":"78.00"},200.81,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/iiaprazole-sodium.html","C19H17N4NaO2S","Sodium Salt","IY-81149 sodium","COC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=C(C=CC(=C3)[N]4C=CC=C4)[N]2[Na]",3.414,4,0,5]
["S5504","Ropivacaine","h8","L3000-23","in 10mM DMSO","Others","Others","Ropivacaine is a member of the amino amide class of local anesthetics.",{"v":274.4,"d":"274.40"},"84057-95-4",{"v":23,"d":"23.00"},83.82,"<1","N/A","https://www.selleckchem.com/products/ropivacaine.html","C17H26N2O","Amide local anesthetics","N/A","CCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",3.853,1,1,4]
["S5507","Trimebutine maleate","a9","L3000-23","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.",503.54,"34140-59-5",{"v":100,"d":"100.00"},198.59,{"v":-1,"d":"-1.00"},-1.99,"https://www.selleckchem.com/products/trimebutine-maleate.html","C26H33NO9","Maleate salt","3, 4, 5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester Maleate Salt;","CCC(COC(=O)C1=CC(=C(OC)C(=C1)OC)OC)(N(C)C)C2=CC=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":1.12,"d":"1.120"},7,0,12]
["S5527","Salmeterol","b9","L3000-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).",415.57,"89365-50-4",{"v":83,"d":"83.00"},199.73,"<1","N/A","http://selleckchem.com/products/salmeterol.html","C25H37NO4","free base","Astmerole, GR-33343X, SN408D","OCC1=C(O)C=CC(=C1)C(O)CNCCCCCCOCCCCC2=CC=CC=C2",4.251,1,4,16]
["S5529","Galangin","c9","L3000-23","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.",270.24,"548-83-4",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/galangin.html","C15H10O5","free base","3,5,7-trihydroxyflavone; Norizalpinin","OC1=CC2=C(C(=C1)O)C(=O)C(=C(O2)C3=CC=CC=C3)O",2.114,2,3,1]
["S5535","Moxifloxacin","d9","L3000-23","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro.",401.43,"151096-09-2",{"v":24,"d":"24.00"},59.79,{"v":-1,"d":"-1.00"},-2.49,"https://www.selleckchem.com/products/moxifloxacin.html","C21H24FN3O4","free base","BAY12-8039","COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CC4CCCNC4C3)F)C5CC5",-0.702,3,1,4]
["S5537","Tizanidine","e9","L3000-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.",253.71,"51322-75-9",{"v":50,"d":"50.00"},197.07,{"v":15,"d":"15.00"},59.12,"http://selleckchem.com/products/tizanidine.html","C9H8ClN5S","α2-adrenergic agonists","N/A","ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1",1.817,3,2,2]
["S5538","Tropisetron","f9","L3000-23","in 10mM DMSO","5-HT Receptor,AChR","Neuronal Signaling","Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.",284.35,"89565-68-4",{"v":10,"d":"10.00"},35.17,{"v":56,"d":"56.00"},196.94,"http://selleckchem.com/products/tropisetron.html","C17H20N2O2","free base","ICS 205-930","CN1C2CCC1CC(C2)OC(=O)C3=C[NH]C4=C3C=CC=C4",2.608,2,1,3]
["S5542","7-Nitroindazole","g9","L3000-23","in 10mM DMSO","NOS","Immunology & Inflammation","7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.",163.13,"2942-42-9",{"v":32,"d":"32.00"},196.16,"N/A","N/A","https://www.selleckchem.com/products/7-nitroindazole.html","C7H5N3O2","free base","N/A","[O-][N+](=O)C1=CC=CC2=C1[NH]N=C2",1.368,1,1,1]
["S5544","D-Ribose","h9","L3000-23","in 10mM DMSO","Others","Others","D-ribose is a naturally occurring sugar involved in producing energy in the body and is also the structural basis of DNA and RNA.",150.13,"50-69-1",{"v":30,"d":"30.00"},199.83,"N/A","N/A","http://selleckchem.com/products/d-ribose.html","C5H10O5","free base","N/A","OCC(O)C(O)C(O)C=O",{"v":-2.28,"d":"-2.280"},1,4,4]
["S5548","7-Hydroxy-4-chromone","a10","L3000-23","in 10mM DMSO","Src","Angiogenesis","7-Hydroxychromone is an inhibitor of Src kinase with IC50 of <300 μM.",162.14,"59887-89-7",{"v":32,"d":"32.00"},197.36,{"v":-1,"d":"-1.00"},-6.17,"https://www.selleckchem.com/products/7-hydroxy-4-chromone.html","C9H6O3","free base","7-Hydroxy-4-benzopyrone","OC1=CC=C2C(=O)C=COC2=C1",1.146,2,1,0]
["S5550","Ethyl gallate","b10","L3000-23","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8, -9, and -3 and the Bcl-2 interacting domain (Bid).",198.17,"831-61-8",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},"N/A","N/A","https://www.selleckchem.com/products/ethyl-gallate.html","C9H10O5","Ester","Phyllemblin, gallic acid ethyl ester","CCOC(=O)C1=CC(=C(O)C(=C1)O)O",1.308,2,3,3]
["S5551","6-Paradol","c10","L3000-23","in 10mM DMSO","COX","Immunology & Inflammation","6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. Paradol is an inhibitor of cyclooxygenase (COX)-2.",278.39,"27113-22-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/6-paradol.html","C17H26O3","free base","N/A","CCCCCCCC(=O)CCC1=CC=C(O)C(=C1)OC",{"v":4.74,"d":"4.740"},2,1,10]
["S5552","Amenamevir","d10","L3000-23","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.",482.55,"841301-32-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/amenamevir.html","C24H26N4O5S","free base","ASP2151","CC1=C(N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CC[S](=O)(=O)CC4)C(=CC=C1)C",{"v":2.24,"d":"2.240"},7,1,6]
["S5554","Lanatoside C","e10","L3000-23","in 10mM DMSO","Akt,Antiviral,Apoptosis related,Autophagy,JAK,mTOR,PI3K,STAT,Wnt/beta-catenin","Immunology & Inflammation","Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.",985.12,"17575-22-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/lanatoside-c.html","C49H76O20","free base","N/A","CC1OC(CC(O)C1OC2CC(O)C(OC3CC(OC(C)=O)C(OC4OC(CO)C(O)C(O)C4O)C(C)O3)C(C)O2)OC5CCC6(C)C(CCC7C6CC(O)C8(C)C(CCC78O)C9=CC(=O)OC9)C5",0.631,12,7,12]
["S5556","(-)-Sparteine Sulfate","f10","L3000-23","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.",422.54,"6160-12-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/sparteini-sulfas.html","C15H26N2.H2SO4.5H2O","sulfate pentahydrate","N/A","O.O.O.O.O.O[S](O)(=O)=O.C1CCN2CC3CC(CN4CCCCC34)C2C1",{"v":0.72,"d":"0.720"},0,0,0]
["S5561","Ethacrynic Acid","g10","L3000-23","in 10mM DMSO","Others","NF-κB","Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.",303.14,"58-54-8",{"v":61,"d":"61.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ethacrynic-acid.html","C13H12Cl2O4","Free Base","N/A","CCC(=C)C(=O)C1=C(Cl)C(=C(OCC(O)=O)C=C1)Cl",3.963,3,0,6]
["S5563","Thioridazine hydrochloride","h10","L3000-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Thioridazine (Aldazine, Mellaril) is a potent antianxiety and antipsychotic agent.",407.04,"130-61-0",{"v":81,"d":"81.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/thioridazine-hydrochloride.html","C21H26N2S2.HCl","hydrochloride","Aldazine, Mellaril","Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC4CCCCN4C)C=C1",5.945,0,0,4]
["S5564","Xylazine","a11","L3000-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.",220.33,"7361-61-7",{"v":44,"d":"44.00"},{"v":199.7,"d":"199.70"},{"v":-1,"d":"-1.00"},-4.54,"https://www.selleckchem.com/products/xylazine.html","C12H16N2S","free base","N/A","CC1=C(NC2=NCCCS2)C(=CC=C1)C",3.265,1,1,2]
["S5566","Dapagliflozin propanediol monohydrate","b11","L3000-23","in 10mM DMSO","SGLT","GPCR & G Protein","Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.",502.98,"960404-48-2",{"v":100,"d":"100.00"},198.82,"<1","N/A","http://selleckchem.com/products/dapagliflozin-propanediol-monohydrate.html","C21H25ClO6.C3H8O2.H2O","monohydrate","N/A","O.CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)C3OC(CO)C(O)C(O)C3O)C=C1.CC(O)CO",1.682,2,6,7]
["S5573","Tilmicosin phosphate","c11","L3000-23","in 10mM DMSO","Antibiotics","Microbiology","Tilmicosin phosphate is a macrolide antibiotic that is used to treat cattle for pathogens that cause Bovine Respiratory Disease.",967.13,"137330-13-3",{"v":100,"d":"100.00"},{"v":103.4,"d":"103.40"},"N/A","N/A","http://selleckchem.com/products/tilmicosin-phosphate.html","C46H80N2O13.H3O4P","phosphate","N/A","CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(O)C(C2O)N(C)C)C(CCN3CC(C)CC(C)C3)CC(C)C(=O)\\C=C\\C(=C\\C1COC4OC(C)C(O)C(OC)C4OC)C.O[P](O)(O)=O",3.392,9,4,12]
["S5579","Chelidonic acid","d11","L3000-23","in 10mM DMSO","Caspase,Decarboxylase,Immunology & Inflammation related,Interleukins,NF-κB","Immunology & Inflammation","Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.",{"v":184.1,"d":"184.10"},"99-32-1",{"v":4,"d":"4.00"},21.73,"N/A","N/A","http://selleckchem.com/products/chelidonic-acid.html","C7H4O6","free base","Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid","OC(=O)C1=CC(=O)C=C(O1)C(O)=O",-0.479,4,0,2]
["S5582","Cytarabine hydrochloride","e11","L3000-23","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.",279.68,"69-74-9",{"v":55,"d":"55.00"},196.65,"N/A","N/A","http://selleckchem.com/products/cytarabine-hydrochloride.html","C9H13N3O5.HCl","hydrochloride","N/A","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.014,3,4,2]
["S5586","3-Hydroxycinnamic acid","f11","L3000-23","in 10mM DMSO","Others","Others","3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar.",164.16,"14755-02-3",{"v":32,"d":"32.00"},194.93,"N/A","N/A","http://selleckchem.com/products/3-hydroxycinnamic-acid.html","C9H8O3","free base","meta-Coumaric acid, m-Coumaric acid, m-Coumarate","OC(=O)/C=C/C1=CC(=CC=C1)O",1.685,1,1,2]
["S5592","Vitamin A","g11","L3000-23","in 10mM DMSO","Vitamin","Metabolism","Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs.",286.45,"68-26-8",{"v":57,"d":"57.00"},198.99,{"v":-1,"d":"-1.00"},-3.49,"https://www.selleckchem.com/products/vitamin-a.html","C20H30O","free base","Retinol","CC(=C/CO)\\C=C\\C=C(C)\\C=C\\C1=C(C)CCCC1(C)C",5.316,0,1,5]
["S5600","Flavokawain A","h11","L3000-23","in 10mM DMSO","Bcl-2,IAP,Survivin","Apoptosis","Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.",314.33,"3420-72-2",{"v":32,"d":"32.00"},{"v":101.8,"d":"101.80"},{"v":-1,"d":"-1.00"},-3.18,"https://www.selleckchem.com/products/flavokawain-a.html","C18H18O5","free base","2'-HYDROXY-4, 4', 6'-TRIMETHOXYCHALCONE","COC1=CC=C(/C=C/C(=O)C2=C(OC)C=C(OC)C=C2O)C=C1",{"v":3.41,"d":"3.410"},4,1,6]
["S5602","Gallocyanine","a2","L3000-24","in 10mM DMSO","Others","Others","Gallocyanine (Solid Violet) is a histological dye used in solution with an iron alum mordant as a hematoxylin substitute in the H&E stain. It has a role as a fluorochrome and a histological dye.",336.73,"1562-85-2",{"v":74,"d":"74.00"},219.76,{"v":-1,"d":"-1.00"},-2.97,"https://www.selleckchem.com/products/gallocyanine.html","C15H13ClN2O5","free base","Solid Violet","[Cl-].CN(C)C1=CC2=C(C=C1)N=C3C(=CC(=C(O)C3=[O+]2)O)C(O)=O",-0.021,2,2,2]
["S5605","Tos-Arg-OMe HCl","b2","L3000-24","in 10mM DMSO","Others","Others","Tos-Arg-OMe HCl, a kind of amino acid  derivatives, is a substrate for trypsin, plasmin, thrombin and orther proteases.",378.87,"1784-03-8",{"v":76,"d":"76.00"},200.59,{"v":-1,"d":"-1.00"},-2.64,"https://www.selleckchem.com/products/tos-arg-ome-hcl.html","C14H23ClN4O4S","free base","N/A","Cl.COC(=O)C(CCCNC(N)=N)N[S](=O)(=O)C1=CC=C(C)C=C1",1.131,4,3,10]
["S5606","Sulfamide","c2","L3000-24","in 10mM DMSO","Others","Others","Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis.",96.11,"7803-58-9",{"v":100,"d":"100.00"},1040.49,{"v":-1,"d":"-1.00"},{"v":-10.4,"d":"-10.40"},"https://www.selleckchem.com/products/sulfamide.html","H4N2O2S","free base","Sulfuric diamide","N[S](N)(=O)=O",-1.863,2,2,0]
["S5609","Chicago Sky Blue 6B","d2","L3000-24","in 10mM DMSO","MIF","Immunology & Inflammation","Chicago Sky Blue 6B (Direct Blue 1, Pontamine sky blue) is a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. It is an inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 0.81 μM.",{"v":992.8,"d":"992.80"},"2610-05-1",{"v":20,"d":"20.00"},20.14,{"v":-1,"d":"-1.00"},-1.01,"https://www.selleckchem.com/products/chicago-sky-blue-6b.html","C34H24N6Na4O16S4","free base","Direct Blue 1, Pontamine sky blue","[Na+].[Na+].[Na+].[Na+].COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(O)C4=C(N)C(=CC(=C4C=C3)[S]([O-])(=O)=O)[S]([O-])(=O)=O)OC)N=NC5=C(O)C6=C(N)C(=CC(=C6C=C5)[S]([O-])(=O)=O)[S]([O-])(=O)=O",-3.754,6,4,11]
["S5623","Bedaquiline","e2","L3000-24","in 10mM DMSO","ATPase","Transmembrane Transporters","Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).",{"v":555.5,"d":"555.50"},"843663-66-1",{"v":12,"d":"12.00"},{"v":21.6,"d":"21.60"},"<1","N/A","https://www.selleckchem.com/products/bedaquiline.html","C32H31BrN2O2","free base","TMC-207, R207910","COC1=NC2=CC=C(Br)C=C2C=C1C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=CC=CC5=CC=CC=C45",6.933,2,0,8]
["S5625","Ammonium lactate","f2","L3000-24","in 10mM DMSO","Bacterial","Microbiology","Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties.",107.11,"515-98-0","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/ammonium-iactate.html","C3H9NO3","free base","Lac-hydrin","[NH4+].CC(O)C([O-])=O",-3.725,0,1,1]
["S5627","Amsacrine hydrochloride","g2","L3000-24","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.",429.92,"54301-15-4",{"v":85,"d":"85.00"},197.71,"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/amsacrine-hydrochloride.html","C21H20ClN3O3S","free base","m-AMSA, acridinyl anisidide","Cl.COC1=CC(=CC=C1NC2=C3C=CC=CC3=NC4=C2C=CC=C4)N[S](C)(=O)=O",{"v":4.18,"d":"4.180"},4,2,5]
["S5640","Ethyl caffeate","h2","L3000-24","in 10mM DMSO","COX,NF-κB,NOS,PGES","NF-κB","Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.",208.21,"102-37-4",{"v":41,"d":"41.00"},196.92,{"v":-1,"d":"-1.00"},{"v":-4.8,"d":"-4.80"},"https://www.selleckchem.com/products/ethyl-caffeate.html","C11H12O4","Ester","ETHYL 3, 4-DIHYDROXYCINNAMATE","CCOC(=O)/C=C/C1=CC(=C(O)C=C1)O",2.018,2,2,4]
["S5649","Hydroxyzine pamoate","a3","L3000-24","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Hydroxyzine Pamoate is the pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties.",763.27,"10246-75-0",{"v":100,"d":"100.00"},131.01,{"v":-1,"d":"-1.00"},-1.31,"https://www.selleckchem.com/products/hydroxyzine-pamoate.html","C44H43ClN2O8","free base","N/A","OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.OC(=O)C4=C(O)C(=C5C=CC=CC5=C4)CC6=C7C=CC=CC7=CC(=C6O)C(O)=O",1.794,3,3,12]
["S5651","Dexrazoxane","b3","L3000-24","in 10mM DMSO","Others","Others","Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.",268.27,"24584-09-6",{"v":54,"d":"54.00"},201.29,"<1","N/A","http://selleckchem.com/products/dexrazoxane.html","C11H16N4O4","free base","ICRF-187","CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-2.104,4,2,3]
["S5654","Indacaterol","c3","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.",392.49,"312753-06-3",{"v":52,"d":"52.00"},132.49,"<1","N/A","http://selleckchem.com/products/indacaterol.html","C24H28N2O3","free base","N/A","CCC1=CC2=C(CC(C2)NCC(O)C3=CC=C(O)C4=C3C=CC(=O)N4)C=C1CC",{"v":3.93,"d":"3.930"},1,4,6]
["S5656","Diphenylpyraline hydrochloride","d3","L3000-24","in 10mM DMSO","Dyes,Histamine Receptor","Neuronal Signaling","Diphenylpyraline hydrochloride is the hydrochloride salt form of diphenylpyraline, which is an antihistamine used in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.",317.85,"132-18-3",{"v":63,"d":"63.00"},198.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/diphenylpyraline-hydrochloride.html","C19H24ClNO","hydrochloride","N/A","Cl.CN1CCC(CC1)OC(C2=CC=CC=C2)C3=CC=CC=C3",3.738,1,0,4]
["S5657","Ertapenem sodium","e3","L3000-24","in 10mM DMSO","Antibiotics","Microbiology","Ertapenem Sodium (MK826) is the sodium salt of ertapenem, a long-acting, broad-spectrum antibiotic of β-lactam subclass.",{"v":497.5,"d":"497.50"},"153773-82-1",{"v":100,"d":"100.00"},201.01,{"v":100,"d":"100.00"},201.01,"http://selleckchem.com/products/ertapenem-sodium.html","C22H24N3NaO7S","sodium salt","MK826","[Na+].CC(O)C1C2C(C)C(=C(N2C1=O)C([O-])=O)SC3CNC(C3)C(=O)NC4=CC(=CC=C4)C(O)=O",-4.602,3,3,7]
["S5658","Omeprazole Sodium","f3","L3000-24","in 10mM DMSO","P450 (e.g. CYP17),Proton Pump","Transmembrane Transporters","Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.",{"v":367.4,"d":"367.40"},"95510-70-6",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://www.selleckchem.com/products/omeprazole-sodium.html","C17H18N3NaO3S","Sodium Salt","N/A","COC1=CC2=C(C=C1)[N]([Na])C(=N2)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S5659","Emedastine","g3","L3000-24","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).",302.41,"87233-61-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/emedastine.html","C17H26N4O","free base","N/A","CCOCC[N]1C2=C(C=CC=C2)N=C1N3CCCN(C)CC3",2.492,2,0,5]
["S5662","Ranitidine","h3","L3000-24","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ranitidine(AH-19065) is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.",{"v":314.4,"d":"314.40"},"66357-35-5",{"v":63,"d":"63.00"},200.38,{"v":-1,"d":"-1.00"},-3.18,"https://www.selleckchem.com/products/ranitidine.html","C13H22N4O3S","free base","AH-19065","CNC(/NCCSCC1=CC=C(CN(C)C)O1)=C\\[N+]([O-])=O",1.039,1,2,10]
["S5663","Minaprine dihydrochloride","a4","L3000-24","in 10mM DMSO","MAO","Metabolism","Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.",{"v":371.3,"d":"371.30"},"25905-77-5",{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},"https://www.selleckchem.com/products/minaprine-dihydrochloride.html","C17H24Cl2N4O","free base","N/A","Cl.Cl.CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3",3.583,3,1,5]
["S5664","Orphenadrine Hydrochloride","b4","L3000-24","in 10mM DMSO","NMDAR","Neuronal Signaling","Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.",305.84,"341-69-5",{"v":61,"d":"61.00"},199.45,{"v":-1,"d":"-1.00"},-3.27,"https://www.selleckchem.com/products/orphenadrine-hydrochloride.html","C18H24ClNO","free base","N/A","Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2C",4.253,1,0,6]
["S5665","Drofenine Hydrochloride","c4","L3000-24","in 10mM DMSO","BChE","Neuronal Signaling","Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers.",353.93,"548-66-3",{"v":71,"d":"71.00"},{"v":200.6,"d":"200.60"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/drofenine-hydrochloride.html","C20H32ClNO2","hydrochloride","N/A","Cl.CCN(CC)CCOC(=O)C(C1CCCCC1)C2=CC=CC=C2",5.106,2,0,9]
["S5666","Moxisylyte hydrochloride","d4","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.",315.84,"964-52-3",{"v":63,"d":"63.00"},199.47,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/moxisylyte-hydrochloride.html","C16H26ClNO3","hydrochloride","thymoxamine hydrochloride","Cl.CC(C)C1=C(OCCN(C)C)C=C(C)C(=C1)OC(C)=O",3.782,3,0,7]
["S5667","Fruquintinib (HMPL-013)","e4","L3000-24","in 10mM DMSO","VEGFR","Angiogenesis","Fruquintinib (HMPL-013) is a small molecule inhibitor with strong potency and high selectivity against VEGFR family. It inhibits VEGFR 1, 2, 3, with IC50 values of 33 nM, 35 nM and 0.5 nM, respectively and shows only weak inhibition of RET, FGFR-1 and c-kit kinases.",393.39,"1194506-26-7",{"v":6,"d":"6.00"},15.25,"<1","N/A","https://www.selleckchem.com/products/fruquintinib.html","C21H19N3O5","Tyrosine kinase inhibitor","N/A","CNC(=O)C1=C(C)OC2=CC(=CC=C12)OC3=C4C=C(OC)C(=CC4=NC=N3)OC",3.111,7,1,5]
["S5669","Isoxsuprine hydrochloride","f4","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.",337.84,"579-56-6",{"v":68,"d":"68.00"},201.28,{"v":4,"d":"4.00"},11.84,"http://www.selleckchem.com/products/isoxsuprine-hydrochloride.html","C18H24ClNO3","hydrochloride","N/A","Cl.CC(COC1=CC=CC=C1)NC(C)C(O)C2=CC=C(O)C=C2",3.384,1,3,7]
["S5670","Chloropyramine hydrochloride","g4","L3000-24","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Chloropyramine hydrochloride (Halopyramine) is a histamine receptor H1 antagonist and has anti-cholinergic, antispasmodic, and antiallergic effects.",326.26,"6170-42-9",{"v":65,"d":"65.00"},199.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/chloropyramine-hydrochloride.html","C16H21Cl2N3","hydrochloride","Halopyramine hydrochloride","Cl.CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=CC=CC=N2",4.149,1,0,6]
["S5683","Isoproterenol sulfate dihydrate","h4","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.",556.62,"299-95-6",{"v":100,"d":"100.00"},179.66,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/isoproterenol-sulfate-dihydrate.html","C22H40N2O12S","dihydrate","N/A","O.O.CC(C)NCC(O)C1=CC=C(O)C(=C1)O.CC(C)NCC(O)C2=CC=C(O)C(=C2)O.O[S](O)(=O)=O",1.177,0,8,8]
["S5684","Lapachol","a5","L3000-24","in 10mM DMSO","Antiviral","Microbiology","Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.",242.27,"84-79-7",{"v":48,"d":"48.00"},198.13,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/lapachol.html","C15H14O3","Free Base","Tecomin, CI75490, Bethabarra wood, Greenhartin","CC(C)=CCC1=C(O)C(=O)C2=CC=CC=C2C1=O",3.036,2,1,2]
["S5686","Tryptanthrin","b5","L3000-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.",248.24,"13220-57-0",{"v":8,"d":"8.00"},32.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tryptanthrin.html","C15H8N2O2","Free Base","N/A","O=C1N2C3=C(C=CC=C3)C(=O)C2=NC4=CC=CC=C14",2.331,3,0,0]
["S5696","JNJ0966","c5","L3000-24","in 10mM DMSO","MMP","Proteases","JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.",360.45,"315705-75-0",{"v":72,"d":"72.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/jnj0966.html","C16H16N4O2S2","Free Base","N/A","COC1=CC=CC=C1NC2=NC(=CS2)C3=C(C)N=C(NC(C)=O)S3",2.999,4,2,5]
["S5698","Ketorolac tromethamine salt","d5","L3000-24","in 10mM DMSO","COX","Immunology & Inflammation","Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.",{"v":376.4,"d":"376.40"},"74103-07-4",{"v":75,"d":"75.00"},199.26,{"v":75,"d":"75.00"},199.26,"http://www.selleckchem.com/products/ketorolac-tromethamine-salt.html","C19H24N2O6","tromethamine salt","N/A","NC(CO)(CO)CO.OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",-2.028,2,4,6]
["S5703","Carvedilol Phosphate","e5","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.",513.48,"610309-89-2",{"v":100,"d":"100.00"},198.23,{"v":-1,"d":"-1.00"},-1.98,"https://www.selleckchem.com/products/carvedilol-phosphate.html","C24H29N2O8P.1/2H2O","Phosphate","N/A","COC1=C(OCCNCC(O)COC2=CC=CC3=C2C4=C([NH]3)C=CC=C4)C=CC=C1.O[P](O)(O)=O",{"v":4.28,"d":"4.280"},3,3,10]
["S5705","Raceanisodamine","f5","L3000-24","in 10mM DMSO","Others","Others","Raceanisodamine (7β-Hydroxyhyoscyamine) is the active ingredient of Chinese herbal extracts that has vasoactive activity used to treat acute disseminated intravascular coagulation in patients in bacteremic shock.",305.37,"17659-49-3",{"v":61,"d":"61.00"},199.76,{"v":30,"d":"30.00"},98.24,"http://selleckchem.com/products/raceanisodamine.html","C17H23NO4","free base","7β-Hydroxyhyoscyamine","CN1C2CC(O)C1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",{"v":0.63,"d":"0.630"},2,2,5]
["S5709","Norgestrel","g5","L3000-24","in 10mM DMSO","ROS","Immunology & Inflammation","Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.",312.45,"6533-00-2",{"v":62,"d":"62.00"},198.43,"<1","N/A","http://selleckchem.com/products/norgestrel.html","C21H28O2","free base","WY-3707, SH-70850, SH-850, FH 122-A","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S5710","Ambroxol","h5","L3000-24","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.",{"v":378.1,"d":"378.10"},"18683-91-5",{"v":76,"d":"76.00"},{"v":201,"d":"201.00"},{"v":-1,"d":"-1.00"},-2.64,"https://www.selleckchem.com/products/ambroxol.html","C13H18Br2N2O","Expectorant","N/A","NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",2.739,0,3,3]
["S5711","Deracoxib","a6","L3000-24","in 10mM DMSO","COX","Immunology & Inflammation","Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).",397.37,"169590-41-4",{"v":80,"d":"80.00"},201.32,"<1","N/A","http://selleckchem.com/products/deracoxib.html","C17H14F3N3O3S","free base","SC-046","COC1=C(F)C=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)F",3.642,4,1,5]
["S5713","Pravastatin","b6","L3000-24","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.",424.53,"81093-37-0",{"v":85,"d":"85.00"},200.22,{"v":85,"d":"85.00"},200.22,"http://www.selleckchem.com/products/pravastatin.html","C23H36O7","Free Base","CS-514","CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC(O)=O)C12",2.156,3,3,11]
["S5714","lurasidone","c6","L3000-24","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.",492.68,"367514-87-2",{"v":7,"d":"7.00"},14.21,"<1","N/A","http://selleckchem.com/products/lurasidone.html","C28H36N4O2S","free base","SM-13496","O=C1C2C3CCC(C3)C2C(=O)N1CC4CCCCC4CN5CCN(CC5)C6=NSC7=CC=CC=C67",4.896,3,0,5]
["S5715","Atorvastatin","d6","L3000-24","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.",558.64,"134523-00-5",{"v":100,"d":"100.00"},179.01,"<1","N/A","http://www.selleckchem.com/products/atorvastatin.html","C33H35FN2O5","Free Base","N/A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC(O)=O)C3=CC=C(F)C=C3)C4=CC=CC=C4",5.555,2,3,12]
["S5716","Abemaciclib (LY2835219)","e6","L3000-24","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.",506.59,"1231929-97-7",{"v":6,"d":"6.00"},11.84,"<1","N/A","http://selleckchem.com/products/abemaciclib.html","C27H32F2N8","free base","LY2835219","CCN1CCN(CC1)CC2=CN=C(NC3=NC=C(F)C(=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)C=C2",4.957,4,1,7]
["S5717","Acetohexamide","f6","L3000-24","in 10mM DMSO","Others","Others","Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea with hypoglycemic activity. It exerts the blood-glucose-lowering effects by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently.",{"v":324.4,"d":"324.40"},"968-81-0",{"v":11,"d":"11.00"},33.91,"<1","N/A","http://selleckchem.com/products/acetohexamide.html","C15H20N2O4S","free base","N/A","CC(=O)C1=CC=C(C=C1)[S](=O)(=O)NC(=O)NC2CCCCC2",2.119,4,2,4]
["S5725","Pempidine","g6","L3000-24","in 10mM DMSO","Others","Others","Pempidine (Pyrilene, Perolysen, 1,2,2,6,6-Pentamethylpiperidine) is a long-acting ganglion-blocking compound.",155.28,"79-55-0","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/pempidine.html","C10H21N","free base","Pyrilene; Perolysen; 1,2,2,6,6-Pentamethylpiperidine","CN1C(C)(C)CCCC1(C)C",2.402,0,0,0]
["S5727","Tetryzoline","h6","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.",200.28,"84-22-0",{"v":40,"d":"40.00"},199.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tetryzoline.html","C13H16N2","Free Base","Tetrahydrozoline","C1CC(C2=NCCN2)C3=C(C1)C=CC=C3",2.185,1,1,1]
["S5728","Delapril Hydrochloride","a7","L3000-24","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.",{"v":489,"d":"489.00"},"83435-67-0",{"v":98,"d":"98.00"},200.41,"<1","N/A","https://www.selleckchem.com/products/delapril-hydrochloride.html","C26H33ClN2O5","hydrochloride","Alindapril Hydrochloride","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(O)=O)C2CC3=C(C2)C=CC=C3",1.253,4,1,12]
["S5729","Fosfosal","b7","L3000-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fosfosal (2-phosphonoxy benzoic acid) is a non-acetylated salicylic acid derivative, with analgesic and anti-inflammatory activity, but without effects on PG biosynthesis in vitro.",{"v":218.1,"d":"218.10"},"6064-83-1",{"v":43,"d":"43.00"},197.16,{"v":-1,"d":"-1.00"},-4.59,"https://www.selleckchem.com/products/fosfosal.html","C7H7O6P","free base","2-phosphonoxy benzoic acid","OC(=O)C1=C(O[P](O)(O)=O)C=CC=C1",0.963,2,0,3]
["S5733","Stearic acid","c7","L3000-24","in 10mM DMSO","Others","Others","Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents.",284.48,"57-11-4",{"v":57,"d":"57.00"},200.37,{"v":-1,"d":"-1.00"},-3.52,"https://www.selleckchem.com/products/stearic-acid.html","C18H36O2","free base","Octadecanoic acid, Isostearic acid, Cetylacetic acid","CCCCCCCCCCCCCCCCCC(O)=O",7.305,1,0,16]
["S5735","Midodrine","d7","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.",254.28,"42794-76-3",{"v":51,"d":"51.00"},200.57,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/midodrine.html","C12H18N2O4","Free Base","N/A","COC1=CC=C(OC)C(=C1)C(O)CNC(=O)CN",-0.548,3,3,6]
["S5737","Diclofenac Epolamine","e7","L3000-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Diclofenac Epolamine (DHEP, DIEP, diclofenac hydroxyethylpyrrolidine) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.",411.32,"119623-66-4",{"v":82,"d":"82.00"},199.36,{"v":82,"d":"82.00"},199.36,"http://www.selleckchem.com/products/diclofenac-epolamine.html","C20H24Cl2N2O3","Epolamine","DHEP, DIEP, diclofenac hydroxyethylpyrrolidine","OCCN1CCCC1.OC(=O)CC2=C(NC3=C(Cl)C=CC=C3Cl)C=CC=C2",{"v":1.58,"d":"1.580"},1,2,6]
["S5740","Palonosetron","f7","L3000-24","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).",296.41,"135729-61-2",{"v":59,"d":"59.00"},199.05,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/palonosetron.html","C19H24N2O","Free Base","RS25259, RS 25259 197","O=C1N(CC2CCCC3=C2C1=CC=C3)C4CN5CCC4CC5",2.745,1,0,1]
["S5749","Chlorpromazine","g7","L3000-24","in 10mM DMSO","5-HT Receptor,Dopamine Receptor,Potassium Channel,Sodium Channel","Neuronal Signaling","Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.",318.86,"50-53-3",{"v":64,"d":"64.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/chlorpromazine.html","C17H19ClN2S","Free Base","CPZ","CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",4.739,0,0,4]
["S5753","Setipiprant (ACT-129968)","h7","L3000-24","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Setipiprant (ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.",402.42,"866460-33-5",{"v":80,"d":"80.00"},{"v":198.8,"d":"198.80"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/act-129968-setipiprant.html","C24H19FN2O3","Free Base","KYTH-105","OC(=O)C[N]1C2=C(CN(CC2)C(=O)C3=C4C=CC=CC4=CC=C3)C5=C1C=CC(=C5)F",4.002,2,0,3]
["S5754","Baricitinib phosphate","a8","L3000-24","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.",469.41,"1187595-84-1",{"v":94,"d":"94.00"},200.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/baricitinib-phosphate.html","C16H20N7O6PS","phosphate","INCB-028050 phosphate, LY-3009104 phosphate","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4.O[P](O)(O)=O",-0.108,5,1,5]
["S5761","Citric acid","b8","L3000-24","in 10mM DMSO","Others","Others","Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle.",192.12,"77-92-9",{"v":38,"d":"38.00"},197.79,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/citric-acid.html","C6H8O7","Free Base","N/A","OC(=O)CC(O)(CC(O)=O)C(O)=O",-1.319,3,0,5]
["S5764","YM 90709","c8","L3000-24","in 10mM DMSO","IL Receptor,Interleukins","Immunology & Inflammation","YM 90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).",359.42,"163769-88-8",{"v":47,"d":"47.00"},130.77,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ym-90709.html","C22H21N3O2","Free Base","N/A","COC1=C(OC)C=C2C(=C1)CC(C)(C)[N]3C2=CC4=NC5=CC=CC=C5N=C34",4.855,4,0,2]
["S5767","Aliskiren","d8","L3000-24","in 10mM DMSO","RAAS","Metabolism","Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.",551.76,"173334-57-1",{"v":100,"d":"100.00"},181.24,{"v":6,"d":"6.00"},10.87,"http://www.selleckchem.com/products/aliskiren.html","C30H53N3O6","Free Base","CGP 60536","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C",3.327,5,4,19]
["S5771","Sulforaphane","e8","L3000-24","in 10mM DMSO","HDAC,Heme Oxygenase,NF-κB,Nrf2,ROS","Immunology & Inflammation","Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,",177.29,"4478-93-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/sulforaphane.html","C6H11NOS2","Free Base","N/A","C[S](=O)CCCCN=C=S",1.157,2,0,5]
["S5772","AS-8351","f8","L3000-24","in 10mM DMSO","Histone Demethylase","Epigenetics","AS-8351 is a histone demethylase inhibitor that could induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.",{"v":291.3,"d":"291.30"},"796-42-9",{"v":58,"d":"58.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/as-8351.html","C17H13N3O2","Free Base","N/A","OC1=CC=C2C=CC=CC2=C1/C=N/NC(=O)C3=CC=NC=C3",2.199,3,2,3]
["S5775","SR1078","g8","L3000-24","in 10mM DMSO","ROR","Transmembrane Transporters","SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.",431.25,"1246525-60-9",{"v":86,"d":"86.00"},199.42,"<1","N/A","http://www.selleckchem.com/products/sr1078.html","C17H10F9NO2","Free Base","N/A","OC(C1=CC=C(NC(=O)C2=CC=C(C=C2)C(F)(F)F)C=C1)(C(F)(F)F)C(F)(F)F",4.852,1,1,6]
["S5780","Prazosin","h8","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.",{"v":383.4,"d":"383.40"},"19216-56-9",{"v":77,"d":"77.00"},200.83,{"v":1,"d":"1.00"},2.61,"http://www.selleckchem.com/products/prazosin.html","C19H21N5O4","Free Base","N/A","COC1=CC2=NC(=NC(=C2C=C1OC)N)N3CCN(CC3)C(=O)C4=CC=CO4",2.107,6,1,4]
["S5781","Raloxifene","a9","L3000-24","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.",473.58,"84449-90-1",{"v":95,"d":"95.00"},{"v":200.6,"d":"200.60"},{"v":1,"d":"1.00"},2.11,"http://www.selleckchem.com/products/raloxifene.html","C28H27NO4S","Free Base","Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129","OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.461,2,2,7]
["S5787","Dronedarone","b9","L3000-24","in 10mM DMSO","Adrenergic Receptor","Transmembrane Transporters","Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).",556.76,"141626-36-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/dronedarone.html","C31H44N2O5S","Free Base","SR33589","CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=C2C=C(N[S](C)(=O)=O)C=C3",7.015,5,1,18]
["S5791","Cyclic Pifithrin-α hydrobromide","c9","L3000-24","in 10mM DMSO","p53","Apoptosis","Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.",349.29,"511296-88-1",{"v":27,"d":"27.00"},{"v":77.3,"d":"77.30"},{"v":1,"d":"1.00"},2.86,"http://www.selleckchem.com/products/cyclic-pifithrin-hydrobromide.html","C16H17BrN2S","hydrobromide","N/A","Br.CC1=CC=C(C=C1)C2=C[N]3C(=N2)SC4=C3CCCC4",4.616,1,0,1]
["S5792","CID 2011756","d9","L3000-24","in 10mM DMSO","PKD","GPCR & G Protein","CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.",396.87,"638156-11-3",{"v":30,"d":"30.00"},75.59,{"v":1,"d":"1.00"},2.52,"http://www.selleckchem.com/products/cid-2011756.html","C22H21ClN2O3","Free Base","N/A","ClC1=CC(=CC=C1)C2=CC=C(O2)C(=O)NC3=CC=C(CN4CCOCC4)C=C3",4.245,3,1,5]
["S5793","Motesanib (AMG-706)","e9","L3000-24","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively.",373.45,"453562-69-1",{"v":75,"d":"75.00"},200.83,{"v":1,"d":"1.00"},2.68,"http://www.selleckchem.com/products/motesanib-amg-706.html","C22H23N5O","Free Base","N/A","CC1(C)CNC2=CC(=CC=C12)NC(=O)C3=C(NCC4=CC=NC=C4)N=CC=C3",2.721,3,3,5]
["S5794","Glycochenodeoxycholic acid","f9","L3000-24","in 10mM DMSO","Others","Others","Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid",449.62,"640-79-9",{"v":90,"d":"90.00"},200.17,{"v":1,"d":"1.00"},2.22,"http://www.selleckchem.com/products/glycochenodeoxycholic-acid.html","C26H43NO5","Free Base","Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate","CC(CCC(=O)NCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",3.074,2,3,6]
["S5795","Rasagiline","g9","L3000-24","in 10mM DMSO","MAO","Metabolism","Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.",171.24,"136236-51-6",{"v":34,"d":"34.00"},198.55,{"v":4,"d":"4.00"},23.36,"http://www.selleckchem.com/products/rasagiline.html","C12H13N","Free Base","TVP-1012","C#CCNC1CCC2=C1C=CC=C2",3.119,0,1,2]
["S5796","Vanoxerine dihydrochloride","h9","L3000-24","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Vanoxerine (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex.",523.49,"67469-78-7",{"v":17,"d":"17.00"},32.47,{"v":5,"d":"5.00"},9.55,"http://www.selleck.cn/products/vanoxerine-dihydrochloride.html","C28H34Cl2F2N2O","dihydrochloride","GBR-12909","Cl.Cl.FC1=CC=C(C=C1)C(OCCN2CCN(CCCC3=CC=CC=C3)CC2)C4=CC=C(F)C=C4",6.878,1,0,10]
["S5800","Alda 1","a10","L3000-24","in 10mM DMSO","Dehydrogenase","Metabolism","Alda 1 is an ALDH2 agonist that activates catalysis for both wild-type ALDH2 (ALDH2*1) and ALDH2*2.",324.16,"349438-38-6",{"v":65,"d":"65.00"},200.52,"<1","N/A","http://www.selleckchem.com/products/alda-1.html","C15H11Cl2NO3","Free Base","N/A","ClC1=C(C(=O)NCC2=CC=C3OCOC3=C2)C(=CC=C1)Cl",3.718,3,1,3]
["S5802","Alprenolol hydrochloride","b10","L3000-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.",285.81,"13707-88-5",{"v":57,"d":"57.00"},199.43,{"v":57,"d":"57.00"},199.43,"http://www.selleckchem.com/products/alprenolol-hydrochloride.html","C15H24ClNO2","Hydrochloride","N/A","Cl.CC(C)NCC(O)COC1=CC=CC=C1CC=C",3.021,1,2,8]
["S5806","Cilostamide","c10","L3000-24","in 10mM DMSO","PDE","Metabolism","Cilostamide (OPC 3689) is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively.",342.43,"68550-75-4",{"v":6,"d":"6.00"},17.52,"<1","N/A","http://www.selleckchem.com/products/cilostamide.html","C20H26N2O3","Free Base","OPC 3689","CN(C1CCCCC1)C(=O)CCCOC2=CC3=C(NC(=O)C=C3)C=C2",2.929,3,1,6]
["S5807","HMN-176","d10","L3000-24","in 10mM DMSO","PLK","Cell Cycle","HMN-176 is an active metabolite of HMN-214, which has a potent antitumor activity in mouse xenograft models. HMN-176 effectively inhibits PLK-1 by interference with its normal subcellular spatial distribution at centrosomes and along the cytoskeletal structure.",382.43,"173529-10-7",{"v":76,"d":"76.00"},198.73,"<1","N/A","http://www.selleckchem.com/products/hmn-176.html","C20H18N2O4S","Free Base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(C=CC=C2)\\C=C\\C3=CC=[N+]([O-])C=C3",2.292,3,1,6]
["S5808","Relugolix","e10","L3000-24","in 10mM DMSO","GNRH Receptor","Endocrinology & Hormones","Relugolix (RVT-601, TAK-385) is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with IC50 of 0.33 nM and 0.32 nM for human GnRHR and monkey GnRHR, respectively.",623.63,"737789-87-6",{"v":61,"d":"61.00"},97.81,"<1","N/A","http://www.selleckchem.com/products/relugolix.html","C29H27F2N7O5S","Free Base","RVT-601, TAK-385","CONC(=O)NC1=CC=C(C=C1)C2=C(CN(C)C)C3=C(S2)N(CC4=C(F)C=CC=C4F)C(=O)N(C3=O)C5=NN=C(OC)C=C5",4.623,7,2,9]
["S5811","Kevetrin hydrochloride","f10","L3000-24","in 10mM DMSO","p53","Apoptosis","Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.",179.67,"66592-89-0",{"v":36,"d":"36.00"},200.37,{"v":36,"d":"36.00"},200.37,"http://www.selleckchem.com/products/kevetrin-hydrochloride.html","C5H10ClN3S","hydrochloride","Thioureidobutyronitrile HCl","Cl.NC(=N)SCCCC#N",1.105,0,1,4]
["S5812","Choline Fenofibrate","g10","L3000-24","in 10mM DMSO","PPAR","Metabolism","Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.",421.91,"856676-23-8",{"v":5,"d":"5.00"},11.85,{"v":9,"d":"9.00"},21.33,"http://www.selleckchem.com/products/choline-fenofibrate.html","C22H28ClNO5","Free Base","ABT-335","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C([O-])=O.C[N+](C)(C)CCO",1.111,2,1,7]
["S5814","cariporide","h10","L3000-24","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.",283.35,"159138-80-4",{"v":87,"d":"87.00"},307.04,"<1","N/A","http://www.selleckchem.com/products/cariporide.html","C12H17N3O3S","Free Base","HOE-642","CC(C)C1=CC=C(C=C1[S](C)(=O)=O)C(=O)NC(N)=N",1.386,3,2,4]
["S5815","WAY-316606","a11","L3000-24","in 10mM DMSO","SFRP,Wnt/beta-catenin","Stem Cells & Wnt","WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.",448.48,"915759-45-4",{"v":90,"d":"90.00"},200.68,{"v":1,"d":"1.00"},2.23,"http://www.selleckchem.com/products/way-316606.html","C18H19F3N2O4S2","Free Base","N/A","FC(F)(F)C1=CC=C(C=C1[S](=O)(=O)NC2CCNCC2)[S](=O)(=O)C3=CC=CC=C3",{"v":2.36,"d":"2.360"},4,2,6]
["S5817","GSK0660","b11","L3000-24","in 10mM DMSO","PPAR","Metabolism","GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (binding assay IC50 = 155 nM; antagonist assay IC50 = 300 nM) and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM.",418.49,"1014691-61-2",{"v":84,"d":"84.00"},200.72,{"v":1,"d":"1.00"},2.39,"http://www.selleckchem.com/products/gsk0660.html","C19H18N2O5S2","Free Base","N/A","COC(=O)C1=C(C=CS1)[S](=O)(=O)NC2=CC=C(NC3=CC=CC=C3)C=C2OC",{"v":3.66,"d":"3.660"},5,2,8]
["S5818","acalisib (GS-9820)","c11","L3000-24","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.",{"v":401.4,"d":"401.40"},"870281-34-8",{"v":80,"d":"80.00"},{"v":199.3,"d":"199.30"},{"v":1,"d":"1.00"},2.49,"http://www.selleckchem.com/products/acalisib-gs-9820.html","C21H16FN7O","Free Base","CAL-120","CC(NC1=NC=NC2=C1[NH]C=N2)C3=NC4=C(C=C(F)C=C4)C(=O)N3C5=CC=CC=C5",3.097,5,2,4]
["S5821","Linoleic acid","d11","L3000-24","in 10mM DMSO","Others","Others","Linoleic acid (9,12-octadecadienoic acid) is an essential fatty acid used in the biosynthesis of arachidonic acid and found in the lipids of cell membranes.,",280.45,"60-33-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/linoleic-acid.html","C18H32O2","Free Base","9,12-octadecadienoic acid","CCCCC/C=C\\C\\C=C/CCCCCCCC(O)=O",6.416,1,0,14]
["S5836","IBMX","e11","L3000-24","in 10mM DMSO","PDE","Metabolism","IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.",222.24,"28822-58-4",{"v":44,"d":"44.00"},197.98,{"v":1,"d":"1.00"},{"v":4.5,"d":"4.50"},"http://www.selleckchem.com/products/ibmx.html","C10H14N4O2","Free Base","Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine","CC(C)CN1C(=O)N(C)C(=O)C2=C1[NH]C=N2",0.608,3,1,2]
["S5839","L-Kynurenine","f11","L3000-24","in 10mM DMSO","AhR","Metabolism","L-Kynurenine ((S)-Kynurenine) is a aryl hydrocarbon receptor agonist. L-Kynurenine is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway.",208.21,"2922-83-0",{"v":42,"d":"42.00"},201.72,{"v":3,"d":"3.00"},14.41,"http://www.selleckchem.com/products/l-kynurenine.html","C10H12N2O3","Free Base","(S)-Kynurenine","NC(CC(=O)C1=C(N)C=CC=C1)C(O)=O",-2.752,2,2,4]
["S5840","Palifosfamide","g11","L3000-24","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.",221.02,"31645-39-3",{"v":44,"d":"44.00"},199.08,{"v":13,"d":"13.00"},58.82,"http://www.selleckchem.com/products/palifosfamide.html","C4H11Cl2N2O2P","Free Base","ZIO-201, Isophosphamide mustard","O[P](=O)(NCCCl)NCCCl",0.018,1,2,6]
["S5841","DKM 2-93","h11","L3000-24","in 10mM DMSO","E1 Activating","Ubiquitin","DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5).",243.69,"65836-72-8",{"v":49,"d":"49.00"},201.08,{"v":1,"d":"1.00"},{"v":4.1,"d":"4.10"},"http://www.selleckchem.com/products/dkm2-93.html","C11H14ClNO3","Free Base","N/A","COC1=CC=C(CNC(=O)CCl)C=C1OC",1.457,3,1,5]
["S5845","Chalcone","a2","L3000-25","in 10mM DMSO","Fungal","Microbiology","Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones with antibacterial, antifungal, antitumor and anti-inflammatory properties.",208.26,"94-41-7",{"v":42,"d":"42.00"},201.67,{"v":1,"d":"1.00"},{"v":4.8,"d":"4.80"},"http://www.selleckchem.com/products/chalcone.html","C15H12O","Free Base","benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone","O=C(\\C=C\\C1=CC=CC=C1)C2=CC=CC=C2",3.701,1,0,3]
["S5851","4'-Methoxychalcone","b2","L3000-25","in 10mM DMSO","PPAR,TNF-alpha","Metabolism","4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.",238.28,"959-23-9",{"v":48,"d":"48.00"},201.44,{"v":1,"d":"1.00"},{"v":4.2,"d":"4.20"},"http://www.selleckchem.com/products/4-methoxychalcone.html","C16H14O2","Free Base","N/A","COC1=CC=C(C=C1)C(=O)\\C=C\\C2=CC=CC=C2",3.685,2,0,4]
["S5863","Metronidazole Benzoate","c2","L3000-25","in 10mM DMSO","Bacterial","Microbiology","Metronidazole Benzoate (Benzoyl metronidazole) is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.",275.26,"13182-89-3",{"v":55,"d":"55.00"},199.81,{"v":1,"d":"1.00"},3.63,"http://www.selleckchem.com/products/metronidazole-benzoate.html","C13H13N3O4","Benzoate","Benzoyl metronidazole","CC1=NC=C([N]1CCOC(=O)C2=CC=CC=C2)[N+]([O-])=O",1.706,3,0,6]
["S5868","DL-Menthol","d2","L3000-25","in 10mM DMSO","Others","Others","DL-Menthol is a racemic mixture of D- and L-menthol. Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.",156.27,"89-78-1",{"v":31,"d":"31.00"},198.37,{"v":31,"d":"31.00"},198.37,"http://www.selleck.cn/products/dl-menthol.html","C10H20O","Free Base","N/A","CC(C)C1CCC(C)CC1O",2.779,0,1,1]
["S5871","Trans-Tranilast","e2","L3000-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.",327.33,"70806-55-2",{"v":65,"d":"65.00"},198.58,{"v":1,"d":"1.00"},3.06,"https://www.selleckchem.com/products/trans-tranilast.html","C18H17NO5","Free Base","N/A","COC1=C(OC)C=C(\\C=C\\C(=O)NC2=C(C=CC=C2)C(O)=O)C=C1",2.679,4,1,6]
["S5872","Estradiol dipropionate","f2","L3000-25","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a semisynthetic, steroidal estrogen which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders.",384.51,"113-38-2",{"v":21,"d":"21.00"},54.61,{"v":1,"d":"1.00"},{"v":2.6,"d":"2.60"},"https://www.selleckchem.com/products/estradiol-dipropionate.html","C24H32O4","Free Base","17-Beta-Estradiol-3,17-Dipropionate","CCC(=O)OC1CCC2C3CCC4=C(C=CC(=C4)OC(=O)CC)C3CCC12C",{"v":5.56,"d":"5.560"},4,0,6]
["S5873","Scopolamine HBr trihydrate","g2","L3000-25","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.",438.31,"6533-68-2",{"v":88,"d":"88.00"},200.77,{"v":88,"d":"88.00"},200.77,"https://www.selleckchem.com/products/scopolamine-hbr-trihydrate.html","C17H28BrNO7","HBr trihydrate","N/A","O.O.O.Br.CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",0.693,3,1,5]
["S5885","Rabeprazole Related Compound E","h2","L3000-25","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of rabeprazole, which is a proton pump inhibitor.",343.44,"117977-21-6",{"v":69,"d":"69.00"},200.91,"<1","N/A","http://www.selleck.cn/products/rabeprazole-related-compound-e.html","C18H21N3O2S","Free Base","Rabeprazole thioether","COCCCOC1=C(C)C(=NC=C1)CSC2=NC3=C([NH]2)C=CC=C3",3.478,4,1,8]
["S5886","Hodostin","a3","L3000-25","in 10mM DMSO","AChR","Neuronal Signaling","Hodostin (Neostigmine methyl sulfate, Syntostigmin, Neostigmeth) is a reversible inhibitor of acetylcholinesterase (AChE), but can not cross the blood-brain barrier. It is used in the treatment of myasthenia gravis.",334.39,"51-60-5",{"v":67,"d":"67.00"},200.36,{"v":67,"d":"67.00"},200.36,"http://www.selleck.cn/products/hodostin.html","C13H22N2O6S","Free Base","Neostigmine methyl sulfate, Syntostigmin, Neostigmeth","CO[S]([O-])(=O)=O.CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C",-2.302,3,0,4]
["S5901","Canagliflozin hemihydrate","b3","L3000-25","in 10mM DMSO","SGLT","GPCR & G Protein","Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.",907.05,"928672-86-0",{"v":100,"d":"100.00"},110.25,"<1","N/A","http://www.selleckchem.com/products/canagliflozin-hemihydrate.html","C48H52F2O11S2","hemihydrate","N/A","O.CC1=C(CC2=CC=C(S2)C3=CC=C(F)C=C3)C=C(C=C1)C4OC(CO)C(O)C(O)C4O.CC5=C(CC6=CC=C(S6)C7=CC=C(F)C=C7)C=C(C=C5)C8OC(CO)C(O)C(O)C8O",6.686,2,8,10]
["S5903","JANEX-1","c3","L3000-25","in 10mM DMSO","JAK","JAK/STAT","JANEX-1 (WHI-P131) is a small molecule inhibitor of JAK3 that selectively inhibits JAK3 at an IC50 of 78 µM without altering the activity of JAK1 or JAK2, or any other protein tyrosine kinases (IC50 ≥ 350 µM).",297.31,"202475-60-3",{"v":5,"d":"5.00"},16.82,"<1","N/A","http://www.selleckchem.com/products/janex-1.html","C16H15N3O3","Free Base","WHI-P131","COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=C(O)C=C3",3.202,4,2,4]
["S5905","Suberohydroxamic acid","d3","L3000-25","in 10mM DMSO","HDAC","Epigenetics","Suberohydroxamic acid (suberic bishydroxamic acid) is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.",204.22,"38937-66-5",{"v":41,"d":"41.00"},200.76,{"v":4,"d":"4.00"},19.59,"http://www.selleckchem.com/products/suberohydroxamic-acid.html","C8H16N2O4","Free Base","suberic bishydroxamic acid","ONC(=O)CCCCCCC(=O)NO",0.235,2,2,7]
["S5913","Cambinol","e3","L3000-25","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).",360.43,"14513-15-6",{"v":21,"d":"21.00"},58.26,"<1","N/A","http://www.selleckchem.com/products/cambinol.html","C21H16N2O2S","Free Base","N/A","OC1=C(CC2=C(NC(=S)NC2=O)C3=CC=CC=C3)C4=CC=CC=C4C=C1",4.431,1,3,3]
["S5915","OAC2","f3","L3000-25","in 10mM DMSO","OCT","Transmembrane Transporters","OAC-2 is an Octamer-binding transcription factor 4 (OCT4) activator, enhancing iPSC reprogramming efficiency.",236.27,"6019-39-2",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://www.selleckchem.com/products/oac2.html","C15H12N2O","Free Base","N/A","O=C(NC1=CC2=C([NH]C=C2)C=C1)C3=CC=CC=C3",2.908,1,2,2]
["S5916","GSK 5959","g3","L3000-25","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.",394.47,"901245-65-6",{"v":6,"d":"6.00"},15.21,"<1","N/A","http://www.selleckchem.com/products/gsk-5959.html","C22H26N4O3","Free Base","N/A","COC1=CC=CC=C1C(=O)NC2=C(C=C3N(C)C(=O)N(C)C3=C2)N4CCCCC4",2.952,3,1,4]
["S5917","Solcitinib","h3","L3000-25","in 10mM DMSO","JAK","JAK/STAT","Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.",389.45,"1206163-45-2",{"v":30,"d":"30.00"},77.03,"<1","N/A","http://www.selleckchem.com/products/solcitinib.html","C22H23N5O2","Free Base","GLPG0778, GSK2586184","CC1(C)CN(C1)C(=O)C2=CC=C(C=C2)C3=CC=CC4=NC(=N[N]34)NC(=O)C5CC5",3.118,4,1,4]
["S5918","CAY10602","a4","L3000-25","in 10mM DMSO","Sirtuin","Epigenetics","CAY10602 is a potent SIRT1 activator.",418.44,"374922-43-7",{"v":56,"d":"56.00"},133.83,"<1","N/A","http://www.selleckchem.com/products/cay10602.html","C22H15FN4O2S","Free Base","N/A","NC1=C(C2=C(N=C3C=CC=CC3=N2)[N]1C4=CC=C(F)C=C4)[S](=O)(=O)C5=CC=CC=C5",4.683,4,1,3]
["S5919","KHS101 hydrochloride","b4","L3000-25","in 10mM DMSO","Microtubule Associated,TACC3","Cytoskeletal Signaling","KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.",375.92,"1784282-12-7",{"v":75,"d":"75.00"},199.51,{"v":3,"d":"3.00"},7.98,"http://www.selleckchem.com/products/khs101-hydrochloride.html","C18H22ClN5S","hydrochloride","N/A","Cl.CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3",4.481,3,2,7]
["S5920","CA-5f","c4","L3000-25","in 10mM DMSO","Autophagy","Autophagy","CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.",388.46,"1370032-19-1",{"v":78,"d":"78.00"},200.79,{"v":1,"d":"1.00"},2.57,"http://www.selleckchem.com/products/ca-5f.html","C24H24N2O3","Free Base","N/A","COC1=CC=C(\\C=C2/CN(C)C\\C(=C/C3=C[NH]C4=C3C=CC=C4)C2=O)C=C1OC",4.168,3,1,4]
["S5927","Proguanil","d4","L3000-25","in 10mM DMSO","Anti-infection,DHFR","Microbiology","Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.",253.73,"500-92-5",{"v":51,"d":"51.00"},{"v":201,"d":"201.00"},{"v":1,"d":"1.00"},3.94,"http://www.selleckchem.com/products/proguanil.html","C11H16ClN5","Free Base","chlorguanide, chloroguanide","CC(C)NC(=N)NC(=N)NC1=CC=C(Cl)C=C1",2.226,0,3,6]
["S5928","Zerumbone","e4","L3000-25","in 10mM DMSO","Others","Others","Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities.",218.33,"471-05-6",{"v":44,"d":"44.00"},201.53,{"v":1,"d":"1.00"},4.58,"http://www.selleckchem.com/products/zerumbone.html","C15H22O","Free Base","N/A","CC\\1=C/CC(C)(C)\\C=C\\C(=O)\\C(=C\\CC1)C",4.455,1,0,0]
["S5929","4-Octyl Itaconate","f4","L3000-25","in 10mM DMSO","Nrf2","Immunology & Inflammation","4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.",242.31,"3133-16-2",{"v":48,"d":"48.00"},198.09,{"v":1,"d":"1.00"},4.13,"http://www.selleckchem.com/products/4-octyl-Itaconate.html","C13H22O4","Free Base","N/A","CCCCCCCCOC(=O)CC(=C)C(O)=O",3.497,3,0,11]
["S5930","PNU 282987 HCl","g4","L3000-25","in 10mM DMSO","AChR","Metabolism","PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor.",301.21,"123464-89-1",{"v":46,"d":"46.00"},152.72,{"v":11,"d":"11.00"},36.52,"https://www.selleckchem.com/products/pnu-282987-hcl.html","C14H18Cl2N2O","Free Base","N/A","Cl.ClC1=CC=C(C=C1)C(=O)NC2CN3CCC2CC3",{"v":2.62,"d":"2.620"},1,1,2]
["S5931","BQCA","h4","L3000-25","in 10mM DMSO","AChR","Metabolism","BQCA (benzylquinolone carboxylic acid) is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR).",309.32,"338747-41-4",{"v":13,"d":"13.00"},42.03,{"v":1,"d":"1.00"},3.23,"http://www.selleckchem.com/products/bqca.html","C18H15NO4","Free Base","benzylquinolone carboxylic acid","COC1=CC=C(CN2C=C(C(O)=O)C(=O)C3=CC=CC=C23)C=C1",2.723,3,0,4]
["S5933","K 858","a5","L3000-25","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.",277.34,"72926-24-0",{"v":55,"d":"55.00"},198.31,{"v":1,"d":"1.00"},3.61,"http://www.selleckchem.com/products/k858.html","C13H15N3O2S","Free Base","N/A","CC(=O)NC1=NN(C(C)=O)C(C)(S1)C2=CC=CC=C2",1.535,3,1,2]
["S5939","Bendamustine (SDX105)","b5","L3000-25","in 10mM DMSO","Others","Others","Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.",358.26,"16506-27-7",{"v":72,"d":"72.00"},200.97,"<1","N/A","http://www.selleck.cn/products/bendamustine.html","C16H21Cl2N3O2","Free Base","SDX105","C[N]1C(=NC2=C1C=CC(=C2)N(CCCl)CCCl)CCCC(O)=O",3.606,2,0,9]
["S5950","Fingolimod","c5","L3000-25","in 10mM DMSO","S1P Receptor","Neuronal Signaling","Fingolimod (FTY-720A, FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.",307.47,"162359-55-9",{"v":13,"d":"13.00"},42.28,{"v":1,"d":"1.00"},3.25,"https://www.selleckchem.com/products/fingolimod.html","C19H33NO2","Free Base","FTY-720A, FTY-720","CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",4.198,0,3,12]
["S6003","Ataluren (PTC124)","d5","L3000-25","in 10mM DMSO","CFTR","Transmembrane Transporters","Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.",284.24,"775304-57-9",{"v":57,"d":"57.00"},200.53,"<1","N/A","http://selleckchem.com/products/PTC124.html","C15H9FN2O3","free base","N/A","OC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C3=CC=CC=C3F",{"v":2.98,"d":"2.980"},4,0,3]
["S6005","VX-702","e5","L3000-25","in 10mM DMSO","p38 MAPK","MAPK","VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.",{"v":404.3,"d":"404.30"},"745833-23-2",{"v":81,"d":"81.00"},200.35,"<1","N/A","http://selleckchem.com/products/VX-702.html","C19H12F4N4O2","free base","N/A","NC(=O)N(C1=NC(=C(C=C1)C(N)=O)C2=C(F)C=C(F)C=C2)C3=C(F)C=CC=C3F",3.682,3,2,4]
["S6058","β-Caryophyllene","f5","L3000-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","β-Caryophyllene is a natural bicyclic sesquiterpene that is a constituent of many essential oils. It acts as a non-steroidal anti-inflammatory drug, a fragrance and a metabolite.",204.35,"87-44-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/caryophyllene.html","C15H24","free base","N/A","CC/1=C\\CCC(=C)C2CC(C)(C)C2CC1",4.753,0,0,0]
["S6068","Doxycycline monohydrate","g5","L3000-25","in 10mM DMSO","Antibiotics","Microbiology","Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity.",462.45,"17086-28-1",{"v":47,"d":"47.00"},101.63,"N/A","N/A","http://www.selleck.cn/products/doxycycline-monohydrate.html","C22H26N2O9","monohydrate","N/A","O.CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",-0.959,3,5,2]
["S6073","Diclofenac acid","h5","L3000-25","in 10mM DMSO","COX,Immunology & Inflammation related","Immunology & Inflammation","Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.",296.15,"15307-86-5",{"v":59,"d":"59.00"},199.22,"N/A","N/A","http://www.selleck.cn/products/diclofenac-acid.html","C14H11Cl2NO2","free base","N/A","OC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",4.373,1,1,4]
["S6095","Quinoline-4-carboxylic acid","a6","L3000-25","in 10mM DMSO","Others","Others","Quinoline-4-carboxylic acid (4-Carboxyquinoline) is a very important structure in a synthetic medicinal chemistry.",173.17,"486-74-8",{"v":34,"d":"34.00"},196.34,"N/A","N/A","http://www.selleck.cn/products/quinoline-4-carboxylic-acid.html","C10H7NO2","free base","4-Carboxyquinoline","OC(=O)C1=C2C=CC=CC2=NC=C1",1.646,2,0,1]
["S6115","Pyridoxal 5′-phosphate hydrate","b6","L3000-25","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Pyridoxal 5′-phosphate (pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP), a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Pyridoxal 5′-phosphate at concentrations < 0.5 mM inhibits of polymerization deoxynucleoside triphosphate catalysed by variety of DNA polymerases isolated from type C RNA tumor viruses. The combination of Pyridoxal 5′-phosphate and NEIL2 will make NEIL2 completely lose its ability to bind damaged DNA.",247.14,"853645-22-4",{"v":10,"d":"10.00"},40.46,"N/A","N/A","http://www.selleck.cn/products/pyridoxal-5-phosphate-hydrate.html","C8H10NO6P.xH2O","hydrate","pyridoxal phosphate, Vitamin B6 phosphate, PAL-P, PLP","CC1=NC=C(CO[P](O)(O)=O)C(=C1O)C=O",0.537,3,1,4]
["S6118","Terpinen-4-ol","c6","L3000-25","in 10mM DMSO","Fungal","Microbiology","Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties.,",154.25,"562-74-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/terpinen-4-ol.html","C10H18O","free base","N/A","CC(C)C1(O)CCC(=CC1)C",{"v":2.55,"d":"2.550"},0,0,1]
["S6122","Cyclohexanecarboxamide","d6","L3000-25","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM).",211.34,"39711-79-0",{"v":42,"d":"42.00"},198.73,{"v":1,"d":"1.00"},4.73,"https://www.selleckchem.com/products/cyclohexanecarboxamide.html","C13H25NO","Free Base","Ethyl menthane carboxamide, WS3, N-Ethyl-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamide, Hexahydrobenzamide","CCNC(=O)C1CC(C)CCC1C(C)C",{"v":3.06,"d":"3.060"},1,1,3]
["S6143","Ureidopropionic acid","e6","L3000-25","in 10mM DMSO","Others","Others","Ureidopropionic acid is an intermediate in the metabolism of uracil.",132.12,"462-88-4",{"v":26,"d":"26.00"},196.79,"N/A","N/A","http://www.selleck.cn/products/ureidopropionic-acid.html","C4H8N2O3","free base","N/A","NC(=O)NCCC(O)=O",-1.107,2,2,3]
["S6147","Hexadecanedioic acid","f6","L3000-25","in 10mM DMSO","Others","Others","Hexadecanedioic acid (Thapsic acid, Hexadecanedioate, Palmitic acid) is a common saturated fatty acid found in animals, plants and microorganisms. It has antitumor activity.",286.41,"505-54-4",{"v":57,"d":"57.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","http://www.selleck.cn/products/hexadecanedioic-acid.html","C16H30O4","free base","Thapsic acid, Hexadecanedioate, Palmitic acid","OC(=O)CCCCCCCCCCCCCCC(O)=O",5.115,2,0,15]
["S6187","N-(5-Aminopentyl)acetamide","g6","L3000-25","in 10mM DMSO","Others","Others","N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound.",144.21,"32343-73-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/n-aminopentyl-acetamide.html","C7H16N2O","free base","Monoacetylcadaverine, N-Acetylcadaverine","CC(=O)NCCCCCN",-0.357,1,2,5]
["S6191","Sudan I","h6","L3000-25","in 10mM DMSO","Dyes","Others","Sudan I (C.I. Solvent Yellow 14) is an azo dye. It causes tumors in the liver or urinary bladder in rats, mice, and rabbits and may be a potential carcinogen for humans.",248.28,"842-07-9",{"v":12.5,"d":"12.50"},50.34,"N/A","N/A","http://www.selleck.cn/products/sudan-i.html","C16H12N2O","free base","C.I. Solvent Yellow 14","OC1=CC=C2C=CC=CC2=C1N=NC3=CC=CC=C3",4.865,2,1,2]
["S6204","Allyl Methyl Sulfide","a7","L3000-25","in 10mM DMSO","Others","Others","Allyl Methyl Sulfide (3-Methylthio-1-propene), a bioactive organosulfur compound found in garlic, is reported to modulate disease states such as cancer and infection.",88.17,"10152-76-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/allyl-methyl-sulfide.html","C4H8S","free base","3-Methylthio-1-propene","CSCC=C",1.411,0,0,2]
["S6249","Picolinic acid (PCL 016)","b7","L3000-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.",123.11,"98-98-6",24.62,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/picolinic-acid-pcl-016.html","C6H5NO2","free base","N/A","OC(=O)C1=NC=CC=C1",0.737,2,0,1]
["S6288","Chlorhexidine diacetate","c7","L3000-25","in 10mM DMSO","Anti-infection","Microbiology","Chlorhexidine diacetate (Hibitane diacetate) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.",625.55,"56-95-1",125.11,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/chlorhexidine-diacetate.html","C26H38Cl2N10O4","diacetate","Hibitane diacetate","CC(O)=O.CC(O)=O.ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1",3.964,2,6,17]
["S6295","2-Methoxybenzoic acid","d7","L3000-25","in 10mM DMSO","Others","Others","2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent.",152.15,"579-75-9",30.43,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/2-methoxybenzoic-acid.html","C8H8O3","free base","o-Anisic acid","COC1=CC=CC=C1C(O)=O",1.443,2,0,2]
["S6341","3-(Methylthio)propionic acid","e7","L3000-25","in 10mM DMSO","Others","Others","3-(Methylthio)propionic acid (3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid) is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro.",120.17,"646-01-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/methylthio-propionic-acid.html","C4H8O2S","free base","3-methylthiopropionate, 4-Thiapentanoic acid, 3-Methylsulfanylpropionic acid","CSCCC(O)=O",0.524,1,0,3]
["S6355","Glycochenodeoxycholic acid sodium salt","f7","L3000-25","in 10mM DMSO","Others","Others","Glycochenodeoxycholic acid is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed.",471.61,"16564-43-5",94.32,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/glycochenodeoxycholic-acid-sodium-salt.html","C26H42NNaO5","sodium salt","N/A","[Na+].CC(CCC(=O)NCC([O-])=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",{"v":1.6,"d":"1.600"},1,3,6]
["S6400","Glucosamine","g7","L3000-25","in 10mM DMSO","HIF","Angiogenesis","Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.",179.17,"3416-24-8",{"v":23,"d":"23.00"},128.37,{"v":36,"d":"36.00"},200.93,"http://www.selleck.cn/products/glucosamine.html","C6H13NO5","Free Base","2-amino-2-deoxy-D-glucose","NC(C=O)C(O)C(O)C(O)CO",-3.081,1,5,5]
["S6402","2-Aminoethanethiol","h7","L3000-25","in 10mM DMSO","Others","Others","2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.",77.15,"60-23-1",{"v":15,"d":"15.00"},194.43,{"v":15,"d":"15.00"},194.43,"http://www.selleck.cn/products/2-aminoethanethiol.html","C2H7NS","Free Base","cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine","NCCS",-0.216,0,1,1]
["S6404","Salicylamide","a8","L3000-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Salicylamide (o-hydroxybenzamide) is a non-prescription drug with analgesic and antipyretic properties.",137.14,"65-45-2",{"v":27,"d":"27.00"},196.88,"˂1","N/A","http://www.selleck.cn/products/salicylamide.html","C7H7NO2","Free Base","o-hydroxybenzamide","NC(=O)C1=C(O)C=CC=C1",{"v":0.59,"d":"0.590"},1,2,1]
["S6407","Tulobuterol hydrochloride","b8","L3000-25","in 10mM DMSO","Androgen Receptor","Neuronal Signaling","Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities.",264.19,"56776-01-3",{"v":53,"d":"53.00"},200.61,{"v":53,"d":"53.00"},200.61,"http://www.selleck.cn/products/tulobuterol-hydrochloride.html","C12H19Cl2NO","hydrochloride","N/A","Cl.CC(C)(C)NCC(O)C1=C(Cl)C=CC=C1",2.834,0,2,4]
["S6409","Zucapsaicin","c8","L3000-25","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.",305.41,"25775-90-0",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://www.selleck.cn/products/zucapsaicin.html","C18H27NO3","Free Base","N/A","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C/C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S6410","Clemizole","d8","L3000-25","in 10mM DMSO","Dopamine Receptor,TRP Channel","Neuronal Signaling","Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels.",325.84,"442-52-4",{"v":65,"d":"65.00"},199.48,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/clemizole.html","C19H20ClN3","Free Base","N/A","ClC1=CC=C(C[N]2C(=NC3=C2C=CC=C3)CN4CCCC4)C=C1",4.527,1,0,4]
["S6411","Nimorazole","e8","L3000-25","in 10mM DMSO","Bacterial","Microbiology","Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity.",226.23,"6506-37-2",{"v":45,"d":"45.00"},198.91,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/nimorazole.html","C9H14N4O3","Free Base","N/A","[O-][N+](=O)C1=CN=C[N]1CCN2CCOCC2",-0.232,2,0,4]
["S6412","Altiratinib","f8","L3000-25","in 10mM DMSO","c-Met,Tie-2,Trk receptor,VEGFR","Protein Tyrosine Kinase","Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM.",510.46,"1345847-93-9",{"v":100,"d":"100.00"},{"v":195.9,"d":"195.90"},"<1","N/A","http://www.selleck.cn/products/altiratinib.html","C26H21F3N4O4","free base","DCC-2701","FC1=CC=C(NC(=O)C2(CC2)C(=O)NC3=C(F)C=C(OC4=CC(=NC=C4)NC(=O)C5CC5)C(=C3)F)C=C1",3.867,5,3,8]
["S6413","fexaramine","g8","L3000-25","in 10mM DMSO","FXR","Metabolism","Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.",496.64,"574013-66-4",{"v":99,"d":"99.00"},199.34,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/fexaramine.html","C32H36N2O3","Free Base","N/A","COC(=O)/C=C/C1=CC=CC(=C1)N(CC2=CC=C(C=C2)C3=CC=C(C=C3)N(C)C)C(=O)C4CCCCC4",{"v":6.87,"d":"6.870"},3,0,9]
["S6414","Apilimod (STA-5326)","h8","L3000-25","in 10mM DMSO","Interleukins,PIKfyve","PI3K/Akt/mTOR","Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.",418.49,"541550-19-0",{"v":84,"d":"84.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/apilimod.html","C23H26N6O2","Free Base","STA-5326","CC1=CC=CC(=C1)\\C=N\\NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4",4.485,6,1,8]
["S6417","GK921","a9","L3000-25","in 10mM DMSO","Glutaminase","Proteases","GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.",344.41,"1025015-40-0",{"v":33,"d":"33.00"},95.82,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/gk921.html","C21H20N4O","Free Base","N/A","C1CCN(C1)CCOC2=NC3=C(N=CC=C3)N=C2C#CC4=CC=CC=C4",3.998,4,0,6]
["S6420","AGI 1067","b9","L3000-25","in 10mM DMSO","Others","Immunology & Inflammation","AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.",616.91,"216167-82-7",{"v":100,"d":"100.00"},{"v":162.1,"d":"162.10"},"<1","N/A","http://www.selleck.cn/products/agi-1067.html","C35H52O5S2","Free Base","N/A","CC(C)(C)C1=C(O)C(=CC(=C1)SC(C)(C)SC2=CC(=C(OC(=O)CCC(O)=O)C(=C2)C(C)(C)C)C(C)(C)C)C(C)(C)C",9.634,3,1,13]
["S6424","TAS-301","c9","L3000-25","in 10mM DMSO","PKC","TGF-beta/Smad","TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. TAS-301 inhibits intimal thickening after balloon injury to rat carotid arteries, and inhibits PKC activation induced by PDGF.",{"v":357.4,"d":"357.40"},"193620-69-8",{"v":71,"d":"71.00"},198.66,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/tas-301.html","C23H19NO3","Free Base","N/A","COC1=CC=C(C=C1)C(C2=CC=C(OC)C=C2)=C3C(=O)NC4=C3C=CC=C4",4.176,3,1,4]
["S6427","AZ876","d9","L3000-25","in 10mM DMSO","Liver X Receptor","Metabolism","AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.",439.57,"898800-26-5",{"v":88,"d":"88.00"},{"v":200.2,"d":"200.20"},{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/az876.html","C24H29N3O3S","Free Base","N/A","CC(C)(C)N1C(=O)C(=C(C2=CC=CC=C2)[S]1(=O)=O)NC3=CC=C(C=C3)N4CCCCC4",3.837,3,1,5]
["S6438","Ufiprazole","e9","L3000-25","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole.",329.42,"73590-85-9",{"v":66,"d":"66.00"},200.35,"<1","N/A","http://www.selleck.cn/products/ufiprazole.html","C17H19N3O2S","Free Base","Omeprazole sulfide","COC1=CC2=C([NH]C(=N2)SCC3=NC=C(C)C(=C3C)OC)C=C1",4.016,4,1,5]
["S6441","Riboflavin Tetrabutyrate","f9","L3000-25","in 10mM DMSO","Others","Others","Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.",656.72,"752-56-7",{"v":100,"d":"100.00"},152.27,"<1","N/A","http://www.selleck.cn/products/riboflavin-tetrabutyrate.html","C33H44N4O10","Tetrabutyrate","N/A","CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(CN1C2=C(C=C(C)C(=C2)C)N=C3C(=O)NC(=O)N=C13)OC(=O)CCC",5.754,12,1,21]
["S6453","Bicyclol","g9","L3000-25","in 10mM DMSO","HBV","Microbiology","Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.",390.34,"118159-48-1",{"v":78,"d":"78.00"},199.83,"<1","N/A","http://www.selleck.cn/products/bicyclol.html","C19H18O9","Free Base","SY-801","COC(=O)C1=CC(=C2OCOC2=C1C3=C4OCOC4=C(OC)C=C3CO)OC",2.102,8,1,6]
["S6455","Clebopride malate","h9","L3000-25","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting.",507.96,"57645-91-7",{"v":100,"d":"100.00"},196.87,{"v":33,"d":"33.00"},64.97,"http://www.selleck.cn/products/clebopride.html","C24H30ClN3O7","malate","N/A","COC1=C(C=C(Cl)C(=C1)N)C(=O)NC2CC[NH+](CC2)CC3=CC=CC=C3.OC(CC(O)=O)C([O-])=O",-1.413,3,3,8]
["S6456","Glycyrrhetinic acid","a10","L3000-25","in 10mM DMSO","Others","Others","Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines.",470.68,"1449-05-4",{"v":94,"d":"94.00"},199.71,"<1","N/A","http://www.selleck.cn/products/glycyrrhetinic-acid.html","C30H46O4","Free Base","N/A","CC1(C)C(O)CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.656,2,1,1]
["S6457","Flurbiprofen Axetil","b10","L3000-25","in 10mM DMSO","COX","Immunology & Inflammation","Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase.",330.35,"91503-79-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/flurbiprofen-axetil.html","C19H19FO4","Free Base","N/A","CC(OC(C)=O)OC(=O)C(C)C1=CC=C(C(=C1)F)C2=CC=CC=C2",3.906,4,0,7]
["S6459","Nifurtimox","c10","L3000-25","in 10mM DMSO","Anti-infection","Microbiology","Nifurtimox (BAY-2502) is an antiprotozoal agent.",287.29,"23256-30-6",{"v":57,"d":"57.00"},198.41,"<1","N/A","http://www.selleck.cn/products/nifurtimox.html","C10H13N3O5S","Free Base","BAY-2502","CC1C[S](=O)(=O)CCN1\\N=C\\C2=CC=C(O2)[N+]([O-])=O",0.772,4,0,3]
["S6471","Lucanthone","d10","L3000-25","in 10mM DMSO","Autophagy","Autophagy","Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.",340.48,"479-50-5",{"v":33,"d":"33.00"},96.92,"<1","N/A","http://www.selleck.cn/products/lucanthone.html","C20H24N2OS","Free Base","N/A","CCN(CC)CCNC1=CC=C(C)C2=C1C(=O)C3=C(S2)C=CC=C3",4.653,1,1,6]
["S6476","Eicosapentaenoic Acid","e10","L3000-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid with antiinflammatory properties, and is present in fish and fish oils, including salmon, cod, and krill oils.",302.45,"10417-94-4",{"v":60,"d":"60.00"},198.38,"<1","N/A","http://www.selleck.cn/products/eicosapentaenoic-acid.html","C20H30O2","Free Base","N/A","CC/C=C\\C\\C=C/C/C=C\\C\\C=C/C/C=C\\CCCC(O)=O",5.994,1,0,13]
["S6484","uridine triacetate","f10","L3000-25","in 10mM DMSO","Others","Others","Uridine triacetate (Vistonuridine, PN401) is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity.",370.31,"4105-38-8",{"v":74,"d":"74.00"},199.83,{"v":7,"d":"7.00"},{"v":18.9,"d":"18.90"},"http://www.selleck.cn/products/uridine-triacetate.html","C15H18N2O9","triacetate","Vistonuridine, PN401","CC(=O)OCC1OC(C(OC(C)=O)C1OC(C)=O)N2C=CC(=O)NC2=O",-1.314,9,1,8]
["S6494","CCCP","g10","L3000-25","in 10mM DMSO","IFN,STING","Immunology & Inflammation","CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).",204.62,"555-60-2",{"v":41,"d":"41.00"},200.37,"<1","N/A","http://www.selleck.cn/products/cccp.html","C9H5ClN4","free base","Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone","ClC1=CC=CC(=C1)NN=C(C#N)C#N",2.469,1,1,2]
["S6495","6-Bromo-2-hydroxy-3-methoxybenzaldehyde","h10","L3000-25","in 10mM DMSO","IRE1","ER stress & UPR","6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.",231.04,"20035-41-0",{"v":46,"d":"46.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://www.selleck.cn/products/6-bromo-2-hydroxy-3-methoxybenzaldehyde.html","C8H7BrO3","free base","N/A","COC1=CC=C(Br)C(=C1O)C=O",2.079,2,1,2]
["S6496","Genz-123346 free base","a11","L3000-25","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.",418.57,"491833-30-8",{"v":84,"d":"84.00"},200.68,"<1","N/A","http://www.selleck.cn/products/genz-123346-free-base.html","C24H38N2O4","free base","N/A","CCCCCCCCC(=O)NC(CN1CCCC1)C(O)C2=CC=C3OCCOC3=C2",4.264,3,2,12]
["S6497","SMI-16a","b11","L3000-25","in 10mM DMSO","Pim","Epigenetics","SMI-16a is a selective Pim kinase inhibitor with IC50 values of 150 nM and 20 nM for Pim1 and Pim2 respectively.",263.31,"587852-28-6",{"v":53,"d":"53.00"},201.28,"<1","N/A","http://www.selleck.cn/products/smi-16a.html","C13H13NO3S","free base","N/A","CCCOC1=CC=C(C=C1)\\C=C2\\SC(=O)NC2=O",2.798,3,1,4]
["S6498","T56-LIMKi","c11","L3000-25","in 10mM DMSO","LIM kinase","Cell Cycle","T56-LIMKi is a selective inhibitor of LIMK2.",389.33,"924473-59-6",{"v":78,"d":"78.00"},200.34,"<1","N/A","http://www.selleck.cn/products/t56-limki.html","C19H14F3N3O3","free base","N/A","CC1=NOC(=C1)C(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F",3.369,4,2,5]
["S6499","PF-6260933","d11","L3000-25","in 10mM DMSO","MAP4K","Hippo","PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity.",296.75,"1811510-56-1",{"v":59,"d":"59.00"},198.82,"<1","N/A","http://www.selleck.cn/products/pf-6260933.html","C16H13ClN4","free base","PF-06260933","NC1=CC=C(C=N1)C2=CN=C(N)C(=C2)C3=CC=C(Cl)C=C3",2.815,2,2,2]
["S6500","KX1-004","e11","L3000-25","in 10mM DMSO","Src","Protein Tyrosine Kinase","KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK; IC50 = 40 µM).",284.29,"518058-84-9",{"v":57,"d":"57.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://www.selleck.cn/products/kx1-004.html","C16H13FN2O2","free base","N/A","OC1=CC(=CC=C1)CNC(=O)C2=CC3=C([NH]2)C=CC(=C3)F",{"v":3.17,"d":"3.170"},1,3,3]
["S6501","NVP 231","f11","L3000-25","in 10mM DMSO","Caspase,Others","Apoptosis","NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage.",431.55,"362003-83-6",{"v":86,"d":"86.00"},199.28,"<1","N/A","http://www.selleck.cn/products/nvp-231.html","C25H25N3O2S","free base","N/A","O=C(NC1=NC2=C(S1)C=C(NC(=O)[C]34C[CH]5C[CH]([CH2]C([CH2]5)C3)C4)C=C2)C6=CC=CC=C6",4.916,3,2,4]
["S6505","X-376","g11","L3000-25","in 10mM DMSO","ALK","Angiogenesis","X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer.",547.41,"1365267-27-1",{"v":100,"d":"100.00"},182.68,"<1","N/A","http://www.selleck.cn/products/x-376.html","C25H25Cl2FN6O3","free base","N/A","CC(OC1=CC(=NN=C1N)C(=O)NC2=CC=C(C=C2)C(=O)N3CCN(C)CC3)C4=C(Cl)C=CC(=C4Cl)F",4.067,5,2,6]
["S6506","Compound 401","h11","L3000-25","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","Compound 401 is a synthetic inhibitor of DNA-PK(IC50=0.28 μM) and mTOR (IC50=5.3 μM). It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.",281.31,"168425-64-7",{"v":7,"d":"7.00"},24.88,"<1","N/A","http://www.selleck.cn/products/compound-401.html","C16H15N3O2","free base","N/A","O=C1C=C(N=C2N1C=CC3=C2C=CC=C3)N4CCOCC4",1.247,3,0,1]
["S6508","Mitapivat","a2","L3000-26","in 10mM DMSO","PKM","Metabolism","Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.",450.55,"1260075-17-9",{"v":90,"d":"90.00"},199.76,"<1","N/A","http://www.selleck.cn/products/mitapivat.html","C24H26N4O3S","free base","AG-348","O=C(N1CCN(CC1)CC2CC2)C3=CC=C(N[S](=O)(=O)C4=C5N=CC=CC5=CC=C4)C=C3",2.695,4,1,6]
["S6509","AG 494","b2","L3000-26","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).",280.28,"133550-35-3",{"v":56,"d":"56.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/ag-494.html","C16H12N2O3","free base","N/A","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NC2=CC=CC=C2",2.437,1,3,3]
["S6511","RIPA-56","c2","L3000-26","in 10mM DMSO","RIP kinase","Apoptosis","RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.",{"v":221.3,"d":"221.30"},"1956370-21-0",{"v":44,"d":"44.00"},198.83,"<1","N/A","http://www.selleck.cn/products/ripa-56.html","C13H19NO2","free base","N/A","CCC(C)(C)C(=O)N(O)CC1=CC=CC=C1",2.972,1,0,4]
["S6513","HG-14-10-04","d2","L3000-26","in 10mM DMSO","ALK","Angiogenesis","HG-14-10-04 is an inhibitor of ALK.",532.08,"1356962-34-9",{"v":10,"d":"10.00"},18.79,"<1","N/A","http://www.selleck.cn/products/hg-14-10-04.html","C29H34ClN7O","free base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)C3=C[NH]C4=CC=CC=C34)C=CC(=C1)N5CCC(CC5)N6CCN(C)CC6",5.241,3,2,6]
["S6516","GNE-477","e2","L3000-26","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR.",504.63,"1032754-81-6",{"v":25,"d":"25.00"},49.54,"<1","N/A","http://www.selleck.cn/products/gne-477.html","C21H28N8O3S2","free base","N/A","CC1=C(CN2CCN(CC2)[S](C)(=O)=O)SC3=C(N=C(N=C13)C4=CN=C(N)N=C4)N5CCOCC5",0.991,7,1,5]
["S6518","Desmethylanethol trithione","f2","L3000-26","in 10mM DMSO","AChR","GPCR & G Protein","Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor.",226.34,"18274-81-2",{"v":45,"d":"45.00"},198.82,"<1","N/A","http://www.selleck.cn/products/desmethylanethol-trithione.html","C9H6OS3","free base","ADT-OH","OC1=CC=C(C=C1)C2=CC(=S)SS2",{"v":3.41,"d":"3.410"},0,1,1]
["S6519","R112","g2","L3000-26","in 10mM DMSO","Syk","Angiogenesis","R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor with Ki value of 96 nM.",{"v":312.3,"d":"312.30"},"575474-82-7",{"v":62,"d":"62.00"},198.53,"<1","N/A","http://www.selleck.cn/products/r112.html","C16H13FN4O2","free base","N/A","OC1=CC=CC(=C1)NC2=NC=C(F)C(=N2)NC3=CC(=CC=C3)O",3.933,2,4,4]
["S6520","WHI-P180","h2","L3000-26","in 10mM DMSO","c-RET,VEGFR","Protein Tyrosine Kinase","WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET (c-RET) and kinase insert domain receptor (KDR), respectively.",297.31,"211555-08-7",{"v":59,"d":"59.00"},198.45,"<1","N/A","http://www.selleck.cn/products/whi-p180.html","C16H15N3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC(=CC=C3)O",3.202,4,2,4]
["S6521","WHI-P258","a3","L3000-26","in 10mM DMSO","JAK","JAK/STAT","WHI-P258 is an inhibitor of JAK3 with Ki value of 72 μM.",281.31,"21561-09-1",{"v":14,"d":"14.00"},49.77,"<1","N/A","http://www.selleck.cn/products/whi-p258.html","C16H15N3O2","free base","N/A","COC1=CC2=C(C=C1OC)C(=NC=N2)NC3=CC=CC=C3",3.444,4,1,4]
["S6522","ST 271","b3","L3000-26","in 10mM DMSO","Phospholipase (e.g. PLA)","Protein Tyrosine Kinase","ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.",272.34,"106392-48-7",{"v":54,"d":"54.00"},198.28,"<1","N/A","http://www.selleck.cn/products/st271.html","C16H20N2O2","free base","N/A","CC(C)C1=C(O)C(=CC(=C1)/C=C(C#N)/C(N)=O)C(C)C",3.285,1,2,4]
["S6523","RG14620","c3","L3000-26","in 10mM DMSO","BCRP,EGFR","Protein Tyrosine Kinase","RG14620 (Tyrphostin RG14620), an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2/BCRP.",275.13,"136831-49-7",{"v":55,"d":"55.00"},199.91,"<1","N/A","http://www.selleck.cn/products/rg14620.html","C14H8Cl2N2","free base","Tyrphostin RG14620","ClC1=CC(=CC(=C1)Cl)\\C=C(C#N)/C2=CC=CN=C2",3.833,1,0,2]
["S6524","NSC 42834","d3","L3000-26","in 10mM DMSO","JAK","JAK/STAT","NSC42834 (JAK2 Inhibitor V, Z3) is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.",344.45,"195371-52-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A",{"v":0,"d":"0.00"},"http://www.selleck.cn/products/nsc-42834.html","C23H24N2O","free base","JAK2 Inhibitor V, Z3","CC(CCC1=NC=CC=C1)(CCC2=NC=CC=C2)C(=O)C3=CC=CC=C3",4.718,3,0,8]
["S6525","AG 555","e3","L3000-26","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG-555 (Tyrphostin B46) is an inhibitor of tyrosine kinase, interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM.",322.36,"133550-34-2",{"v":64,"d":"64.00"},198.54,"<1","N/A","http://www.selleck.cn/products/ag555.html","C19H18N2O3","free base","Tyrphostin B46","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NCCCC2=CC=CC=C2",3.221,1,3,6]
["S6527","Kobe2602","f3","L3000-26","in 10mM DMSO","Ras","Cell Cycle","Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).",419.31,"454453-49-7",{"v":84,"d":"84.00"},200.33,"<1","N/A","http://www.selleck.cn/products/kobe2602.html","C14H9F4N5O4S","free base","N/A","[O-][N+](=O)C1=CC(=CC(=C1NNC(=S)NC2=CC=C(F)C=C2)[N+]([O-])=O)C(F)(F)F",4.976,0,3,8]
["S6529","NIH-12848","g3","L3000-26","in 10mM DMSO","Others","Metabolism","NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM.",385.41,"959551-10-1",{"v":77,"d":"77.00"},199.79,"<1","N/A","http://www.selleck.cn/products/nih-12848.html","C20H14F3N3S","free base","N/A","FC(F)(F)C1=CC=CC=C1C2=NC3=CC=CC=C3C(=N2)NCC4=CC=CS4",5.621,2,1,5]
["S6532","kb-NB77-78","h3","L3000-26","in 10mM DMSO","Others","Others","kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1.",331.48,"1350622-33-1",{"v":66,"d":"66.00"},199.11,"<1","N/A","http://www.selleck.cn/products/kb-nb77-78.html","C18H25NO3Si","free base","N/A","CC(C)(C)[Si](C)(C)OC1=CC2=C(OC(=O)C3=C2CCCN3)C=C1",4.871,3,1,3]
["S6533","Briciclib","a4","L3000-26","in 10mM DMSO","eIF","ER stress & UPR","Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).",474.42,"865783-99-9",{"v":95,"d":"95.00"},200.24,"<1","N/A","http://www.selleck.cn/products/briciclib.html","C19H23O10PS","free base","ON-014185","COC1=CC(=C(/C=C/[S](=O)(=O)CC2=CC=C(OC)C(=C2)O[P](O)(O)=O)C(=C1)OC)OC",2.319,7,0,10]
["S6536","TTP 22","b4","L3000-26","in 10mM DMSO","Casein Kinase","Metabolism","TTP22 is a casein kinase 2 (CK2) inhibitor with an IC50 value of 100 nM. It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.",330.42,"329907-28-0",{"v":66,"d":"66.00"},199.75,"<1","N/A","http://www.selleck.cn/products/ttp-22.html","C16H14N2O2S2","free base","N/A","CC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)SCCC(O)=O",3.927,3,0,5]
["S6537","CVT-313","c4","L3000-26","in 10mM DMSO","CDK","Autophagy","CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases.",400.47,"199986-75-9",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://www.selleck.cn/products/cvt-313.html","C20H28N6O3","free base","N/A","COC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3C(C)C)N(CCO)CCO)C=C1",2.217,4,3,10]
["S6538","B-Raf IN 1","d4","L3000-26","in 10mM DMSO","Raf","MAPK","B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively. It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα.",515.53,"950736-05-7",{"v":100,"d":"100.00"},193.98,"<1","N/A","http://www.selleck.cn/products/b-rafin-1.html","C29H24F3N5O","free base","N/A","CN(C)CC1=CC=C(C=C1)C2=C3N=CC=C([N]3N=C2)C4=CC(=CC=C4)NC(=O)C5=CC=CC(=C5)C(F)(F)F",5.368,3,1,7]
["S6541","MTX-211","e4","L3000-26","in 10mM DMSO","EGFR,PI3K","Protein Tyrosine Kinase","MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase.",478.33,"1952236-05-3",{"v":24,"d":"24.00"},50.17,"<1","N/A","http://www.selleck.cn/products/mtx-211.html","C20H14Cl2FN5O2S","free base","N/A","C[S](=O)(=O)NC1=CC(=CN=C1Cl)C2=CC3=C(NC4=CC=C(F)C(=C4)Cl)N=CN=C3C=C2",4.499,5,2,5]
["S6543","ZD-4190","f4","L3000-26","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.",459.27,"413599-62-9",{"v":12,"d":"12.00"},26.13,"<1","N/A","http://www.selleck.cn/products/zd-4190.html","C19H16BrFN6O2","free base","N/A","COC1=CC2=C(NC3=CC=C(Br)C=C3F)N=CN=C2C=C1OCC[N]4C=CN=N4",4.229,6,1,7]
["S6544","SR-3029","g4","L3000-26","in 10mM DMSO","Casein Kinase","Metabolism","SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively.",480.45,"1454585-06-8",{"v":47,"d":"47.00"},97.82,"<1","N/A","http://www.selleck.cn/products/sr-3029.html","C23H19F3N8O","free base","N/A","FC1=CC(=CC=C1)[N]2C=NC3=C2N=C(N=C3NCC4=NC5=C(F)C(=CC=C5[NH]4)F)N6CCOCC6",4.175,5,2,5]
["S6550","URB602","h4","L3000-26","in 10mM DMSO","Lipase","Metabolism","URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).",295.38,"565460-15-3",{"v":59,"d":"59.00"},199.74,"<1","N/A","http://www.selleck.cn/products/urb602.html","C19H21NO2","free base","N/A","O=C(NC1=CC(=CC=C1)C2=CC=CC=C2)OC3CCCCC3",{"v":4.97,"d":"4.970"},2,1,4]
["S6555","AZD2098","a5","L3000-26","in 10mM DMSO","CCR","Immunology & Inflammation","AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.",334.18,"566203-88-1",{"v":67,"d":"67.00"},200.49,"<1","N/A","http://www.selleck.cn/products/azd2098.html","C11H9Cl2N3O3S","free base","N/A","COC1=NC=CN=C1N[S](=O)(=O)C2=C(Cl)C(=CC=C2)Cl",2.407,5,1,4]
["S6561","4-IBP","b5","L3000-26","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).",420.29,"155798-08-6",{"v":84,"d":"84.00"},199.86,"<1","N/A","http://www.selleck.cn/products/4-ibp.html","C19H21IN2O","free base","N/A","IC1=CC=C(C=C1)C(=O)NC2CCN(CC2)CC3=CC=CC=C3",{"v":3.31,"d":"3.310"},1,1,4]
["S6565","JK184","c5","L3000-26","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","JK184 inhibits Gli in the Hedgehog (Hh) pathway with IC50 of 30 nM in mammalian cells.",350.44,"315703-52-7",{"v":70,"d":"70.00"},199.75,"<1","N/A","http://www.selleck.cn/products/jk184.html","C19H18N4OS","free base","N/A","CCOC1=CC=C(NC2=NC(=CS2)C3=C(C)N=C4C=CC=C[N]34)C=C1",4.108,3,1,5]
["S6566","NSC23005 Sodium","d5","L3000-26","in 10mM DMSO","Others","Others","NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM).",305.33,"1796596-46-7",{"v":61,"d":"61.00"},199.78,{"v":61,"d":"61.00"},199.78,"http://www.selleck.cn/products/nsc23005-sodium.html","C13H16NNaO4S","Sodium","N/A","[Na+].[O-]C(=O)C1=CC=C(C=C1)[S](=O)(=O)NC2CCCCC2",0.755,2,1,4]
["S6567","Src Inhibitor 1","e5","L3000-26","in 10mM DMSO","Src","Angiogenesis","Src Inhibitor 1 is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes.",{"v":373.4,"d":"373.40"},"179248-59-0",{"v":9,"d":"9.00"},{"v":24.1,"d":"24.10"},"<1","N/A","http://www.selleck.cn/products/src-inhibitor-1.html","C22H19N3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC=C(OC4=CC=CC=C4)C=C3",5.004,5,1,6]
["S6569","VUF10460","f5","L3000-26","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","VUF10460 is a histamine H4 receptor agonist.",269.34,"1028327-66-3",{"v":54,"d":"54.00"},200.49,"<1","N/A","http://www.selleck.cn/products/vuf10460.html","C15H19N5","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC=CC=C3)N",2.431,2,1,2]
["S6571","BQR695","g5","L3000-26","in 10mM DMSO","PI4K","PI3K/Akt/mTOR","BQR695 (NVP-BQR695) is a quinoxaline that displays sub-micromolar potency against human PI4KIIIβ (IC50~90 nM).",352.39,"1513879-21-4",{"v":70,"d":"70.00"},198.64,"<1","N/A","http://www.selleck.cn/products/bqr695.html","C19H20N4O3","free base","NVP-BQR695","CNC(=O)CNC1=CN=C2C=CC(=CC2=N1)C3=CC=C(OC)C(=C3)OC",2.187,5,2,6]
["S6573","MD2-IN-1","h5","L3000-26","in 10mM DMSO","TLR","Immunology & Inflammation","MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.",358.39,"111797-22-9",{"v":72,"d":"72.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://www.selleck.cn/products/md2-in-1.html","C20H22O6","free base","N/A","COC1=C(OC)C=C(C=C1)C(=O)/C=C/C2=CC(=C(OC)C(=C2)OC)OC",{"v":3.62,"d":"3.620"},6,0,8]
["S6575","C-176","a6","L3000-26","in 10mM DMSO","STING","Immunology & Inflammation","STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.",358.09,"314054-00-7",{"v":72,"d":"72.00"},201.07,"<1","N/A","http://www.selleck.cn/products/c-176-sting-inhibitor.html","C11H7IN2O4","free base","N/A","[O-][N+](=O)C1=CC=C(O1)C(=O)NC2=CC=C(I)C=C2",2.606,2,1,3]
["S6578","Longdaysin","b6","L3000-26","in 10mM DMSO","Casein Kinase","Metabolism","Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.",335.33,"1353867-91-0",{"v":67,"d":"67.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/longdaysin.html","C16H16F3N5","free base","N/A","CC(C)[N]1C=NC2=C1N=CN=C2NCC3=CC=CC(=C3)C(F)(F)F",3.571,3,1,5]
["S6588","Methylprednisolone hemisuccinate","c6","L3000-26","in 10mM DMSO","Others","Others","Methylprednisolone sodium succinate is a glucocorticoid used to treat a variety health issues including severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal diseases and endocrine disorders.",474.54,"2921-57-5",{"v":95,"d":"95.00"},200.19,"<1","N/A","https://www.selleckchem.com/products/methylprednisolone-hemisuccinate-s6588.html","C26H34O8","free base","N/A","CC1CC2C3CCC(O)(C(=O)COC(=O)CCC(O)=O)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",1.736,5,1,7]
["S6590","Hydrocortisone butyrate","d6","L3000-26","in 10mM DMSO","Others","Others","Hydrocortisone butyrate is a potent topical corticosteroid that can be used to treat a range of inflammatory skin conditions.",432.55,"13609-67-1",{"v":87,"d":"87.00"},201.13,"<1","N/A","http://www.selleck.cn/products/hydrocortisone-butyrate.html","C25H36O6","free base","N/A","CCCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C)C(=O)CO",2.785,4,2,6]
["S6601","(±)-Equol","e6","L3000-26","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.",242.27,"94105-90-5",{"v":48,"d":"48.00"},198.13,"<1","N/A","https://www.selleckchem.com/products/equol-1.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=C(C2)C=CC(=C3)O",3.211,1,2,1]
["S6605","AR7","f6","L3000-26","in 10mM DMSO","Retinoid Receptor","Metabolism","AR7 is a retinoic acid receptor α (RARα) antagonist.",257.71,"80306-38-3",{"v":4,"d":"4.00"},15.52,"<1","N/A","http://www.selleck.cn/products/ar7.html","C15H12ClNO","free base","N/A","CC1=CC=C(C=C1)C2=NC3=C(OC2)C=C(Cl)C=C3",4.227,2,0,1]
["S6610","GSK2981278","g6","L3000-26","in 10mM DMSO","ROR","Transmembrane Transporters","GSK2981278 is a highly potent and selective inverse agonist for RORγ.",461.61,"1474110-21-8",{"v":92,"d":"92.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://www.selleck.cn/products/gsk2981278.html","C25H35NO5S","free base","N/A","CCC1=CC=C(C=C1)N(CC(C)C)[S](=O)(=O)C2=CC=C(OCC3CCOCC3)C(=C2)CO",4.456,4,1,10]
["S6614","Fursultiamine","h6","L3000-26","in 10mM DMSO","Vitamin","Metabolism","Fursultiamine (Thiamine tetrahydrofurfuryl disulfide) is a nutritional supplement and vitamin B1 derivative, with potential antineoplastic activity.",398.54,"804-30-8",{"v":80,"d":"80.00"},200.73,{"v":3,"d":"3.00"},7.53,"http://www.selleck.cn/products/fursultiamine.html","C17H26N4O3S2","free base","Thiamine tetrahydrofurfuryl disulfide","CC1=NC=C(CN(C=O)/C(C)=C(CCO)/SSCC2CCCO2)C(=N1)N",0.221,4,2,9]
["S7000","AP26113-analog (ALK-IN-1)","a7","L3000-26","in 10mM DMSO","ALK,EGFR","Protein Tyrosine Kinase","AP26113-analog (ALK-IN-1) is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR.",529.01,"1197958-12-5",{"v":45,"d":"45.00"},85.06,"<1","N/A","http://selleckchem.com/products/ap26113.html","C26H34ClN6O2P","free base","N/A","COC1=CC(=CC=C1NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3[P](C)(C)=O)N4CCC(CC4)N(C)C",5.126,6,2,8]
["S7003","AZD2932","b7","L3000-26","in 10mM DMSO","c-Kit,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.",447.49,"883986-34-3",{"v":89,"d":"89.00"},198.89,"<1","N/A","http://selleckchem.com/products/azd2932.html","C24H25N5O4","free base","N/A","COC1=C(OC)C=C2C(=NC=NC2=C1)OC3=CC=C(CC(=O)NC4=C[N](N=C4)C(C)C)C=C3",{"v":3.65,"d":"3.650"},7,1,8]
["S7006","BAY-61-3606","c7","L3000-26","in 10mM DMSO","Apoptosis related,Syk","Angiogenesis","BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). BAY-61-3606 induces cell cycle arrest and apoptosis.",463.32,"648903-57-5",{"v":14,"d":"14.00"},30.22,"<1","N/A","http://selleckchem.com/products/bay-61-3606.html","C20H18N6O3.2HCl","dihydrochloride","N/A","Cl.Cl.COC1=CC=C(C=C1OC)C2=CC3=NC=C[N]3C(=N2)NC4=NC=CC=C4C(N)=O",3.082,6,2,6]
["S7007","Binimetinib (MEK162)","d7","L3000-26","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.",441.23,"606143-89-9",{"v":88,"d":"88.00"},199.44,"<1","N/A","http://selleckchem.com/products/mek162.html","C17H15BrF2N4O3","free base","ARRY-162,ARRY-438162","C[N]1C=NC2=C1C=C(C(=O)NOCCO)C(=C2F)NC3=C(F)C=C(Br)C=C3",2.775,3,3,6]
["S7008","PP2","e7","L3000-26","in 10mM DMSO","Src","Angiogenesis","PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.",301.77,"172889-27-9",{"v":60,"d":"60.00"},198.83,"<1","N/A","http://selleckchem.com/products/pp2.html","C15H16ClN5","free base","AG 1879,AGL 1879","CC(C)(C)[N]1N=C(C2=CC=C(Cl)C=C2)C3=C(N)N=CN=C13",3.435,3,1,2]
["S7009","LCL161","f7","L3000-26","in 10mM DMSO","IAP,Mitochondrial Metabolism","Apoptosis","LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).",500.63,"1005342-46-0",{"v":100,"d":"100.00"},199.75,"<1","N/A","http://selleckchem.com/products/lcl161.html","C26H33FN4O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(F)C=C4",3.785,4,2,8]
["S7010","GDC-0152","g7","L3000-26","in 10mM DMSO","IAP","Apoptosis","GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.",498.64,"873652-48-3",{"v":99,"d":"99.00"},198.54,{"v":3,"d":"3.00"},6.02,"http://selleckchem.com/products/gdc-0152.html","C25H34N6O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4",2.767,5,3,8]
["S7014","Merestinib (LY2801653)","h7","L3000-26","in 10mM DMSO","Axl,c-Met,DDR,FLT3,Mertk,ROS1","Protein Tyrosine Kinase","Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.",552.53,"1206799-15-6",{"v":100,"d":"100.00"},180.99,"<1","N/A","http://selleckchem.com/products/ly2801653-merestinib.html","C30H22F2N6O3","free base","N/A","C[N]1N=CC2=CC(=C(C=C12)C3=C[NH]N=C3)OC4=C(F)C=C(NC(=O)C5=CC=C(C)N(C5=O)C6=CC=C(F)C=C6)C=C4",{"v":4.5,"d":"4.500"},5,2,6]
["S7015","Birinapant (TL32711)","a8","L3000-26","in 10mM DMSO","Apoptosis related,HIV,IAP","Apoptosis","Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.",806.94,"1260251-31-7",{"v":100,"d":"100.00"},123.92,"<1","N/A","http://selleckchem.com/products/birinapant-tl32711.html","C42H56F2N8O6","free base","TL32711","CCC(NC(=O)C(C)NC)C(=O)N1CC(O)CC1CC2=C([NH]C3=C2C=CC(=C3)F)C4=C(CC5CC(O)CN5C(=O)C(CC)NC(=O)C(C)NC)C6=C([NH]4)C=C(F)C=C6",{"v":3.08,"d":"3.080"},4,8,15]
["S7016","VS-5584 (SB2343)","b8","L3000-26","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.",354.41,"1246560-33-7",{"v":71,"d":"71.00"},200.33,"<1","N/A","http://selleckchem.com/products/vs-5584-sb2343.html","C17H22N8O","free base","N/A","CC(C)[N]1C(=NC2=C1N=C(N=C2C3=CN=C(N)N=C3)N4CCOCC4)C",1.272,6,1,3]
["S7018","CZC24832","c8","L3000-26","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.",{"v":364.4,"d":"364.40"},"1159824-67-5",{"v":5,"d":"5.00"},13.72,"<1","N/A","http://selleckchem.com/products/czc24832.html","C15H17FN6O2S","free base","N/A","CC(C)(C)N[S](=O)(=O)C1=CN=CC(=C1)C2=C[N]3N=C(N)N=C3C(=C2)F",0.815,5,2,4]
["S7024","Stattic","d8","L3000-26","in 10mM DMSO","Apoptosis related,STAT","JAK/STAT","Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.",211.19,"19983-44-9",{"v":42,"d":"42.00"},198.87,"<1","N/A","http://selleckchem.com/products/stattic.html","C8H5NO4S","free base","N/A","[O-][N+](=O)C1=CC=C2C=C[S](=O)(=O)C2=C1",0.939,2,0,1]
["S7025","Embelin","e8","L3000-26","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,IAP","Apoptosis","Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.",294.39,"550-24-3",{"v":59,"d":"59.00"},200.41,"<1","N/A","http://selleckchem.com/products/embelin.html","C17H26O4","free base","Embelic Acid, NSC 91874","CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O",{"v":4.62,"d":"4.620"},2,2,10]
["S7028","Duvelisib (IPI-145)","f8","L3000-26","in 10mM DMSO","PI3K","Angiogenesis","Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.",416.86,"1201438-56-3",{"v":83,"d":"83.00"},199.11,"<1","N/A","http://selleckchem.com/products/ipi-145-ink1197.html","C22H17ClN6O","free base","INK1197","CC(NC1=NC=NC2=C1N=C[NH]2)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)Cl",3.648,4,2,4]
["S7029","AZD2461","g8","L3000-26","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.",395.43,"1174043-16-3",{"v":79,"d":"79.00"},199.78,"<1","N/A","http://selleckchem.com/products/azd2461.html","C22H22FN3O3","free base","N/A","COC1CCN(CC1)C(=O)C2=CC(=CC=C2F)CC3=NNC(=O)C4=CC=CC=C34",1.993,4,1,4]
["S7030","RG-7112","h8","L3000-26","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7033","GSK2656157","a9","L3000-26","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.",416.45,"1337532-29-2",{"v":32,"d":"32.00"},76.84,"<1","N/A","http://selleckchem.com/products/gsk2656157.html","C23H21FN6O","free base","N/A","C[N]1C=C(C2=C(F)C3=C(C=C2)N(CC3)C(=O)CC4=CC=CC(=N4)C)C5=C(N)N=CN=C15",2.926,4,1,3]
["S7036","XL019","b9","L3000-26","in 10mM DMSO","JAK","JAK/STAT","XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.",444.53,"945755-56-6",{"v":16,"d":"16.00"},35.99,"<1","N/A","http://selleckchem.com/products/xl019.html","C25H28N6O2","free base","N/A","O=C(NC1=CC=C(C=C1)C2=CC=NC(=N2)NC3=CC=C(C=C3)N4CCOCC4)C5CCCN5",3.106,4,3,6]
["S7037","Wnt-C59 (C59)","c9","L3000-26","in 10mM DMSO","PORCN","Stem Cells & Wnt","Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.",379.45,"1243243-89-1",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/wnt-c59-c59.html","C25H21N3O","free base","N/A","CC1=NC=CC(=C1)C2=CC=C(CC(=O)NC3=CC=C(C=C3)C4=CC=CN=C4)C=C2",3.667,3,1,5]
["S7038","Epoxomicin (BU-4061T)","d9","L3000-26","in 10mM DMSO","Apoptosis related,Proteasome","Proteases","Epoxomicin (BU-4061T, Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Epoxomicin promotes apoptosis.",554.72,"134381-21-8",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/epoxomicin-bu-4061t.html","C28H50N4O7","free base","Aids010837","CCC(C)C(NC(=O)C(C(C)CC)N(C)C(C)=O)C(=O)NC(=O)C(NC(CC(C)C)C(=O)C1(C)CO1)C(C)O",1.793,6,4,16]
["S7039","PD168393","e9","L3000-26","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.",369.22,"194423-15-9",{"v":73,"d":"73.00"},197.71,"<1","N/A","http://selleckchem.com/products/pd168393.html","C17H13BrN4O","free base","N/A","BrC1=CC(=CC=C1)NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23",4.043,3,2,4]
["S7040","AZD3514","f9","L3000-26","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.",519.56,"1240299-33-5",{"v":100,"d":"100.00"},192.47,"<1","N/A","http://selleckchem.com/products/azd3514.html","C25H32F3N7O2","free base","N/A","CC(=O)N1CCN(CCOC2=CC=C(C=C2)C3CCN(CC3)C4=N[N]5C(=NN=C5C(F)(F)F)CC4)CC1",2.235,5,0,7]
["S7041","CX-6258 HCl","g9","L3000-26","in 10mM DMSO","Pim","JAK/STAT","CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.",{"v":498.4,"d":"498.40"},"1353859-00-3",{"v":57,"d":"57.00"},114.37,{"v":89,"d":"89.00"},178.57,"http://selleckchem.com/products/CX-6258.html","C26H24ClN3O3.HCl","Hydrochloride","N/A","Cl.CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)\\C=C4\\C(=O)NC5=C4C=C(Cl)C=C5",4.416,3,1,3]
["S7046","Brefeldin A","h9","L3000-26","in 10mM DMSO","Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy","Transmembrane Transporters","Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.",280.36,"20350-15-6",{"v":4,"d":"4.00"},14.27,"<1","N/A","http://selleckchem.com/products/brefeldin-a.html","C16H24O4","free base","BFA, Cyanein, Decumbin","CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1",2.152,2,2,0]
["S7049","Oprozomib (ONX 0912)","a10","L3000-26","in 10mM DMSO","Proteasome","Proteases","Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.",532.61,"935888-69-0",{"v":100,"d":"100.00"},187.75,"<1","N/A","http://selleckchem.com/products/oprozomib-onx-0912.html","C25H32N4O7S","free base","PR-047","COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3",-0.202,8,3,14]
["S7050","AZ20","b10","L3000-26","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM in a cell-free assay, 8-fold selectivity over mTOR.",412.51,"1233339-22-4",{"v":83,"d":"83.00"},201.21,"<1","N/A","http://selleckchem.com/products/az20.html","C21H24N4O3S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=O)=O)C4=CC=CC5=C4C=C[NH]5",3.038,5,1,4]
["S7051","CGI1746","c10","L3000-26","in 10mM DMSO","BTK","Angiogenesis","CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM.",579.69,"910232-84-7",{"v":100,"d":"100.00"},172.51,"<1","N/A","http://selleckchem.com/products/cgi1746.html","C34H37N5O4","free base","N/A","CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N3CCOCC3)C1=O)C4=CC=CC(=C4C)NC(=O)C5=CC=C(C=C5)C(C)(C)C",3.513,5,2,7]
["S7057","LY2874455","d10","L3000-26","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.",444.31,"1254473-64-7",{"v":88,"d":"88.00"},198.06,"<1","N/A","http://selleckchem.com/products/ly2874455.html","C21H19Cl2N5O2","free base","N/A","CC(OC1=CC=C2[NH]N=C(\\C=C\\C3=C[N](CCO)N=C3)C2=C1)C4=C(Cl)C=NC=C4Cl",4.121,4,2,7]
["S7059","Tezacaftor (VX-661)","e10","L3000-26","in 10mM DMSO","CFTR","Transmembrane Transporters","Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.",{"v":520.5,"d":"520.50"},"1152311-62-0",{"v":100,"d":"100.00"},192.12,"<1","N/A","http://selleckchem.com/products/vx-661.html","C26H27F3N2O6","free base","N/A","CC(C)(CO)C1=CC2=CC(=C(F)C=C2[N]1CC(O)CO)NC(=O)C3(CC3)C4=CC=C5OC(F)(F)OC5=C4",5.215,3,4,8]
["S7060","PP1","f10","L3000-26","in 10mM DMSO","Src","Angiogenesis","PP1 (AGL 1872, EI 275) is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM.",281.36,"172889-26-8",{"v":4,"d":"4.00"},14.22,"<1","N/A","http://selleckchem.com/products/pp1.html","C16H19N5","free base","AGL 1872, EI 275","CC1=CC=C(C=C1)C2=N[N](C3=NC=NC(=C23)N)C(C)(C)C",3.257,3,1,2]
["S7063","LY2090314","g10","L3000-26","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.",512.53,"603288-22-8",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/ly2090314.html","C28H25FN6O3","free base","N/A","FC1=CC2=C3[N](CCN(C2)C(=O)N4CCCCC4)C=C(C3=C1)C5=C(C(=O)NC5=O)C6=CN=C7C=CC=C[N]67",2.707,4,1,2]
["S7065","MK-8745","h10","L3000-26","in 10mM DMSO","Aurora Kinase","Cell Cycle","MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.",431.91,"885325-71-3",{"v":86,"d":"86.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-8745.html","C20H19ClFN5OS","free base","N/A","FC1=C(C=CC=C1Cl)C(=O)N2CCN(CC2)CC3=CC=CC(=N3)NC4=NC=CS4",3.805,3,1,5]
["S7067","Tepotinib (EMD 1214063)","a11","L3000-26","in 10mM DMSO","Autophagy,c-Met","Protein Tyrosine Kinase","Tepotinib (EMD 1214063, MSC2156119) is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib (EMD 1214063) induces autophagy. Phase 1.",492.57,"1100598-32-0",{"v":5,"d":"5.00"},10.15,"<1","N/A","http://selleckchem.com/products/emd-1214063.html","C29H28N6O2","free base","MSC2156119","CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4N=C(C=CC4=O)C5=CC(=CC=C5)C#N",3.629,5,0,7]
["S7070","GSK J4 HCl (GSKJ4 HCl)","b11","L3000-26","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.",453.96,"1797983-09-5",{"v":90,"d":"90.00"},198.26,{"v":90,"d":"90.00"},198.26,"http://selleckchem.com/products/gsk-j4-hcl.html","C24H27N5O2.HCl","Hydrochloride","N/A","Cl.CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",4.663,5,1,8]
["S7071","(+)-Bicuculline","c11","L3000-26","in 10mM DMSO","ADC Cytotoxin,GABA Receptor","Neuronal Signaling","(+)-Bicuculline (d-Bicuculline) is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.",367.35,"485-49-4",{"v":21,"d":"21.00"},57.17,"<1","N/A","http://selleckchem.com/products/bicuculline.html","C20H17NO6","free base","d-Bicuculline","CN1CCC2=CC3=C(OCO3)C=C2C1C4OC(=O)C5=C6OCOC6=CC=C45",2.829,6,0,1]
["S7076","T0901317","d11","L3000-26","in 10mM DMSO","Apoptosis related,FXR,Liver X Receptor,ROR","Metabolism","T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of 20nM for LXRα and 5 μM for FXR, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.",481.33,"293754-55-9",{"v":96,"d":"96.00"},199.45,"<1","N/A","http://selleckchem.com/products/t0901317.html","C17H12F9NO3S","free base","N/A","OC(C1=CC=C(C=C1)N(CC(F)(F)F)[S](=O)(=O)C2=CC=CC=C2)(C(F)(F)F)C(F)(F)F",4.826,2,0,8]
["S7077","Cilengitide trifluoroacetate","e11","L3000-26","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.",702.68,"199807-35-7",{"v":100,"d":"100.00"},142.31,{"v":8,"d":"8.00"},11.38,"http://selleckchem.com/products/cilengitide-emd-121974-nsc-707544.html","C29H41F3N8O9","Trifluoroacetat","EMD 121974, NSC 707544","CC(C)C1N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O.OC(=O)C(F)(F)F",-0.565,7,6,11]
["S7079","SGC 0946","f11","L3000-26","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.",618.57,"1561178-17-3",{"v":100,"d":"100.00"},161.66,"<1","N/A","http://selleckchem.com/products/sgc-0946.html","C28H40BrN7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=C(Br)C4=C3N=CN=C4N",3.278,4,5,10]
["S7080","RN486","g11","L3000-26","in 10mM DMSO","BTK","Angiogenesis","RN486 is a potent and selective BTK inhibitor with IC50 of 4 nM.",606.69,"1242156-23-5",{"v":62,"d":"62.00"},102.19,"<1","N/A","http://selleckchem.com/products/rn486.html","C35H35FN6O3","free base","N/A","CN1CCN(CC1)C2=CN=C(NC3=CC(=CN(C)C3=O)C4=CC=CC(=C4CO)N5C=CC6=CC(=CC(=C6C5=O)F)C7CC7)C=C2",3.061,3,2,7]
["S7083","Ceritinib (LDK378)","h11","L3000-26","in 10mM DMSO","ALK,FLT3,IGF-1R,Serine/threonin kinase","Protein Tyrosine Kinase","Ceritinib (LDK378) is a potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays. Ceritinib (LDK378) also inhibits IGF-1R, InsR, STK22D and FLT3 with IC50 of 8 nM, 7 nM, 23 nM and 60 nM, respectively. Phase 3.",558.14,"1032900-25-6",{"v":20,"d":"20.00"},35.83,"<1","N/A","http://selleckchem.com/products/ldk378.html","C28H36ClN5O3S","free base","N/A","CC(C)OC1=C(NC2=NC(=C(Cl)C=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4",6.479,5,3,9]
["S7086","IWR-1-endo","a2","L3000-27","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.",409.44,"1127442-82-3",{"v":21,"d":"21.00"},51.29,"<1","N/A","http://selleckchem.com/products/iwr-1-endo.html","C25H19N3O3","free base","endo-IWR 1, IWR-1","CC12C3CC(C=C3)C1C(=O)N(C2=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6",3.075,4,1,3]
["S7087","GSK2334470","b2","L3000-27","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM in a cell-free assay, with no activity at other close related AGC-kinases.",462.59,"1227911-45-6",{"v":90,"d":"90.00"},194.56,"<1","N/A","http://selleckchem.com/products/gsk2334470.html","C25H34N8O","free base","N/A","CNC1=NC(=CC(=N1)N2CC(CCC2C)C(=O)NC3CCCCC3)C4=CC5=C(C=C4)C(=N[NH]5)N",4.516,4,4,5]
["S7088","UNC1215","c2","L3000-27","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.",529.72,"1415800-43-9",{"v":100,"d":"100.00"},188.78,"<1","N/A","http://selleckchem.com/products/nuc1215.html","C32H43N5O2","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6",3.351,2,1,6]
["S7090","GSK923295","d2","L3000-27","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.",592.13,"1088965-37-0",{"v":100,"d":"100.00"},168.88,"<1","N/A","http://selleckchem.com/products/gsk923295.html","C32H38ClN5O4","free base","N/A","CC(C)OC1=CC=C(C=C1Cl)C(=O)NC(CNC(=O)CN(C)C)CC2=CC=C(C=C2)C3=C[N]4C=CC=C(C(C)O)C4=N3",4.004,4,3,12]
["S7091","Zotarolimus (ABT-578)","e2","L3000-27","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Zotarolimus (ABT-578,A 179578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.",966.21,"221877-54-9",{"v":100,"d":"100.00"},{"v":103.5,"d":"103.50"},"<1","N/A","http://selleckchem.com/products/zotarolimus-abt-578.html","C52H79N5O12","free base","A 179578","COC1CC(CCC1[N]2C=NN=N2)CC(C)C3CC(=O)C(C)/C=C(C)/C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC4CCC(C)C(O)(O4)C(=O)C(=O)N5CCCCC5C(=O)O3)OC",5.793,13,1,7]
["S7092","SANT-1","f2","L3000-27","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.",373.49,"304909-07-7",{"v":21,"d":"21.00"},56.23,"<1","N/A","http://selleckchem.com/products/sant-1.html","C23H27N5","free base","N/A","CC1=N[N](C2=CC=CC=C2)C(=C1\\C=N\\N3CCN(CC3)CC4=CC=CC=C4)C",3.759,2,0,5]
["S7093","IPA-3","g2","L3000-27","in 10mM DMSO","PAK","Cytoskeletal Signaling","IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).",350.45,"42521-82-4",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/ipa-3.html","C20H14O2S2","free base","N/A","OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O",5.871,0,2,3]
["S7094","PF-3758309","h2","L3000-27","in 10mM DMSO","Apoptosis related,PAK","Cytoskeletal Signaling","PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4  with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.",490.62,"898044-15-0",{"v":98,"d":"98.00"},199.75,"<1","N/A","http://selleckchem.com/products/pf-3758309.html","C25H30N8OS","free base","PF-03758309","CN(C)CC(NC(=O)N1CC2=C([NH]N=C2NC3=NC(=NC4=C3SC=C4)C)C1(C)C)C5=CC=CC=C5",4.077,4,3,6]
["S7096","KY02111","a3","L3000-27","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.",376.86,"1118807-13-8",{"v":75,"d":"75.00"},199.01,"<1","N/A","http://selleckchem.com/products/ky02111.html","C18H17ClN2O3S","free base","N/A","COC1=CC=C(CCC(=O)NC2=NC3=CC=C(Cl)C=C3S2)C=C1OC",4.362,4,1,6]
["S7097","HSP990 (NVP-HSP990)","b3","L3000-27","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","HSP990 (NVP-HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM. NVP-HSP990 induces cell cycle arrest and apoptosis.",379.39,"934343-74-5",{"v":75,"d":"75.00"},197.69,"<1","N/A","http://selleckchem.com/products/hsp990-nvp-hsp990.html","C20H18FN5O2","free base","N/A","COC1=NC(=CC=C1)C2=C(C=CC(=C2)F)C3CC4=C(C(=NC(=N4)N)C)C(=O)N3",2.669,5,2,3]
["S7098","PD123319","c3","L3000-27","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.",508.61,"130663-39-7",{"v":100,"d":"100.00"},196.61,{"v":100,"d":"100.00"},196.61,"http://selleckchem.com/products/pd123319.html","C31H32N4O3","free base","N/A","CN(C)C1=C(C)C=C(C[N]2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(O)=O)C=C1",4.593,3,0,7]
["S7099","(-)-Blebbistatin","d3","L3000-27","in 10mM DMSO","ATPase","Transmembrane Transporters","(-)-Blebbistatin ((S)-(-)-Blebbistatin) is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.",292.33,"856925-71-8",{"v":58,"d":"58.00"},198.41,"<1","N/A","http://selleckchem.com/products/blebbistatin.html","C18H16N2O2","free base","(S)-(-)-Blebbistatin","CC1=CC=C2N=C3N(CCC3(O)C(=O)C2=C1)C4=CC=CC=C4",2.426,2,0,1]
["S7102","Berzosertib (VE-822)","e3","L3000-27","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.",463.55,"1232416-25-9",{"v":36,"d":"36.00"},77.66,"<1","N/A","http://selleckchem.com/products/ve-822.html","C24H25N5O3S","free base","VX970, M6620","CNCC1=CC=C(C=C1)C2=NOC(=C2)C3=C(N)N=CC(=N3)C4=CC=C(C=C4)[S](=O)(=O)C(C)C",3.697,6,2,7]
["S7103","Taselisib (GDC 0032)","f3","L3000-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Taselisib (GDC 0032, RG7604) is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.",460.53,"1282512-48-4",{"v":70,"d":"70.00"},{"v":152,"d":"152.00"},"<1","N/A","http://selleckchem.com/products/gdc-0032.html","C24H28N8O2","free base","RG7604","CC(C)[N]1N=C(C)N=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)C5=C[N](N=C5)C(C)(C)C(N)=O",{"v":2.47,"d":"2.470"},6,1,5]
["S7104","AZD1208","g3","L3000-27","in 10mM DMSO","Apoptosis related,Autophagy,Pim","JAK/STAT","AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.",379.48,"1204144-28-4",{"v":75,"d":"75.00"},197.64,"<1","N/A","http://selleckchem.com/products/azd-1208.html","C21H21N3O2S","free base","N/A","NC1CCCN(C1)C2=C(C=CC=C2C3=CC=CC=C3)\\C=C\\4SC(=O)NC4=O",3.283,2,2,3]
["S7106","AZD3463","h3","L3000-27","in 10mM DMSO","ALK,Apoptosis related,Autophagy,IGF-1R","Protein Tyrosine Kinase","AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy.",448.95,"1356962-20-3",{"v":24,"d":"24.00"},53.46,"<1","N/A","http://selleckchem.com/products/azd3463.html","C24H25ClN6O","free base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)C3=C[NH]C4=C3C=CC=C4)C=CC(=C1)N5CCC(N)CC5",4.316,3,3,5]
["S7110","(+)-JQ1","a4","L3000-27","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1","N/A","http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7111","IDO-IN-2","b4","L3000-27","in 10mM DMSO","IDO/TDO","Metabolism","IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.",282.38,"1402836-58-1",{"v":15,"d":"15.00"},53.12,"<1","N/A","http://selleckchem.com/products/nlg919.html","C18H22N2O","free base","RG 6078, NLG-919 analogue, GDC-0919 analogue","OC(CC1[N]2C=NC=C2C3=C1C=CC=C3)C4CCCCC4",3.255,1,1,3]
["S7113","Zebularine (NSC 309132)","c4","L3000-27","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay.",{"v":228.2,"d":"228.20"},"3690-10-6",{"v":46,"d":"46.00"},201.58,{"v":46,"d":"46.00"},201.58,"http://selleckchem.com/products/zebularine.html","C9H12N2O5","free base","4-Deoxyuridine","OCC1OC(C(O)C1O)N2C=CC=NC2=O",-1.747,3,3,2]
["S7114","NU6027","d4","L3000-27","in 10mM DMSO","CDK","Cell Cycle","NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.",251.28,"220036-08-8",{"v":50,"d":"50.00"},198.98,"<1","N/A","http://selleckchem.com/products/nu6027.html","C11H17N5O2","free base","N/A","NC1=NC(=C(N=O)C(=N1)OCC2CCCCC2)N",2.576,4,2,4]
["S7115","AMG-517","e4","L3000-27","in 10mM DMSO","TRP Channel","Transmembrane Transporters","AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.",{"v":430.4,"d":"430.40"},"659730-32-2",{"v":86,"d":"86.00"},199.81,"<1","N/A","http://selleckchem.com/products/amg-517.html","C20H13F3N4O2S","free base","N/A","CC(=O)NC1=NC2=C(S1)C=CC=C2OC3=CC(=NC=N3)C4=CC=C(C=C4)C(F)(F)F",4.785,5,1,5]
["S7119","Go6976","f4","L3000-27","in 10mM DMSO","FLT3,JAK,PKC","TGF-beta/Smad","Go6976 (PD406976) is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.",377.42,"136194-77-9",{"v":18,"d":"18.00"},47.69,"<1","N/A","http://selleckchem.com/products/go6976.html","C24H18N4O","free base","PD406976","C[N]1C2=C(C=CC=C2)C3=C1C4=C(C5=C3C(=O)NC5)C6=C(C=CC=C6)[N]4CCC#N",4.168,1,1,2]
["S7121","Tovorafenib (MLN2480)","g4","L3000-27","in 10mM DMSO","Raf","MAPK","Tovorafenib (MLN2480, BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101) is an oral, selective pan-Raf kinase inhibitor in chinical trials.",506.29,"1096708-71-2",{"v":100,"d":"100.00"},197.52,"<1","N/A","http://selleckchem.com/products/mln2480.html","C17H12Cl2F3N7O2S","free base","BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101","CC(NC(=O)C1=C(Cl)C(=NC=N1)N)C2=NC=C(S2)C(=O)NC3=NC=C(Cl)C(=C3)C(F)(F)F",2.932,6,3,6]
["S7122","XL888","h4","L3000-27","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1.",503.64,"1149705-71-4",{"v":100,"d":"100.00"},198.55,"<1","N/A","http://selleckchem.com/products/xl888.html","C29H37N5O3","free base","N/A","CCC(C)NC1=C(C=C(C)C(=C1)C(=O)NC2CC3CCC(C2)N3C4=NC=C(C=C4)C(=O)C5CC5)C(N)=O",3.772,4,3,9]
["S7124","SC144","a5","L3000-27","in 10mM DMSO","P-gp","Transmembrane Transporters","SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.",{"v":322.3,"d":"322.30"},"895158-95-9",{"v":28,"d":"28.00"},86.88,"<1","N/A","http://selleckchem.com/products/sc144.html","C16H11FN6O","free base","N/A","FC1=CC2=C(C=C1)[N]3C=CC=C3C(=N2)NNC(=O)C4=CN=CC=N4",1.819,4,2,3]
["S7125","KPT-185","b5","L3000-27","in 10mM DMSO","CRM1","Transmembrane Transporters","KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.",355.31,"1333151-73-7",{"v":71,"d":"71.00"},199.83,"<1","N/A","http://selleckchem.com/products/kpt-185.html","C16H16F3N3O3","free base","N/A","COC1=CC(=CC(=C1)C(F)(F)F)C2=N[N](\\C=C/C(=O)OC(C)C)C=N2",2.923,5,0,7]
["S7126","Marinopyrrole A (Maritoclax)","c5","L3000-27","in 10mM DMSO","Bcl-2","Apoptosis","Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM.",510.15,"1227962-62-0",{"v":100,"d":"100.00"},196.02,"<1","N/A","http://selleckchem.com/products/marinopyrrole-a-maritoclax.html","C22H12Cl4N2O4","free base","N/A","OC1=CC=CC=C1C(=O)C2=C([N]3C(=C(Cl)C=C3C(=O)C4=CC=CC=C4O)Cl)C(=C(Cl)[NH]2)Cl",6.953,2,3,5]
["S7127","TIC10 Analogue","d5","L3000-27","in 10mM DMSO","Akt","PI3K/Akt/mTOR","TIC10 Analogue is an analogue of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"41276-02-2",{"v":11,"d":"11.00"},28.46,"<1","N/A","http://selleckchem.com/products/tic10.html","C24H26N4O","free base","N/A","CC1=C(CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5CCN=C25)C=CC=C1",3.212,2,0,4]
["S7129","PYR-41","e5","L3000-27","in 10mM DMSO","Apoptosis related,E1 Activating","Ubiquitin","PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. PYR-41 induce apoptosis.",{"v":371.3,"d":"371.30"},"418805-02-4",{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/pyr-41.html","C17H13N3O7","free base","N/A","CCOC(=O)C1=CC=C(C=C1)N2NC(=O)C(=C/C3=CC=C(O3)[N+]([O-])=O)/C2=O",{"v":1.87,"d":"1.870"},5,1,6]
["S7130","PR-619","f5","L3000-27","in 10mM DMSO","Autophagy,DUB","Ubiquitin","PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.",223.28,"2645-32-1",{"v":45,"d":"45.00"},201.54,"<1","N/A","http://selleckchem.com/products/pr-619.html","C7H5N5S2","free base","N/A","NC1=C(SC#N)C=C(SC#N)C(=N1)N",1.212,1,2,2]
["S7132","P5091 (P005091)","g5","L3000-27","in 10mM DMSO","DUB","Ubiquitin","P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.",348.22,"882257-11-6",{"v":28,"d":"28.00"},80.41,"<1","N/A","http://selleckchem.com/products/p5091-p005091.html","C12H7Cl2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=CC(=C2Cl)Cl)[N+]([O-])=O",4.989,1,0,4]
["S7133","P22077","h5","L3000-27","in 10mM DMSO","DUB","Ubiquitin","P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.",315.32,"1247819-59-5",{"v":63,"d":"63.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/p22077.html","C12H7F2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=C(F)C=C2F)[N+]([O-])=O",4.071,1,0,4]
["S7134","IU1","a6","L3000-27","in 10mM DMSO","Autophagy,DUB","Proteases","IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy.",300.37,"314245-33-5",{"v":60,"d":"60.00"},199.75,"<1","N/A","http://selleckchem.com/products/iu1.html","C18H21FN2O","free base","N/A","CC1=CC(=C(C)[N]1C2=CC=C(F)C=C2)C(=O)CN3CCCC3",3.409,1,0,4]
["S7135","LDN-57444","b6","L3000-27","in 10mM DMSO","DUB","Proteases","LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.",397.64,"668467-91-2",{"v":11,"d":"11.00"},27.66,"<1","N/A","http://selleckchem.com/products/ldn-57444.html","C17H11Cl3N2O3","free base","N/A","CC(=O)O\\N=C/1C(=O)N(CC2=CC(=CC=C2Cl)Cl)C3=CC=C(Cl)C=C13",4.343,4,0,4]
["S7136","CGK 733","c6","L3000-27","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.",555.84,"905973-89-9",{"v":100,"d":"100.00"},179.91,"<1","N/A","http://selleckchem.com/products/cgk-733.html","C23H18Cl3FN4O3S","free base","N/A","[O-][N+](=O)C1=CC(=CC=C1F)NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)C(Cl)(Cl)Cl",6.795,1,3,10]
["S7137","GLPG0634 analogue","d6","L3000-27","in 10mM DMSO","JAK","JAK/STAT","GLPG0634 analogue is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.",410.43,"1206101-20-3",{"v":82,"d":"82.00"},199.79,"<1","N/A","http://www.selleck.cn/products/glpg0634.html","C23H18N6O2","Free Base","N/A","O=C(NC1=N[N]2C(=N1)C=CC=C2C3=CC=C(OCC4=CC=C(N=C4)C#N)C=C3)C5CC5",3.695,5,1,6]
["S7138","BMS-833923","e6","L3000-27","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.",473.57,"1059734-66-5",{"v":95,"d":"95.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/bms-833923.html","C30H27N5O","free base","XL139","CNCC1=CC(=C(C)C=C1)NC(=O)C2=CC=C(NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5)C=C2",6.214,3,3,7]
["S7139","CFTRinh-172","f6","L3000-27","in 10mM DMSO","CFTR","Transmembrane Transporters","CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.",{"v":409.4,"d":"409.40"},"307510-92-5",{"v":82,"d":"82.00"},200.29,"<1","N/A","http://selleckchem.com/products/cftrinh-172.html","C18H10F3NO3S2","free base","CFTR inhibitor 172","OC(=O)C1=CC=C(C=C1)\\C=C/2SC(=S)N(C2=O)C3=CC=CC(=C3)C(F)(F)F",5.195,2,0,4]
["S7140","TCID","g6","L3000-27","in 10mM DMSO","DUB","Ubiquitin","TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.",283.92,"30675-13-9",{"v":23,"d":"23.00"},81.01,"<1","N/A","http://selleckchem.com/products/tcid.html","C9H2Cl4O2","free base","N/A","ClC1=C(Cl)C(=C2C(=O)CC(=O)C2=C1Cl)Cl",3.982,2,0,0]
["S7142","NSC697923","h6","L3000-27","in 10mM DMSO","E2 conjugating","Ubiquitin","NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.",267.26,"343351-67-7",{"v":53,"d":"53.00"},198.31,"<1","N/A","http://selleckchem.com/products/nsc697923.html","C11H9NO5S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(O2)[N+]([O-])=O",2.665,3,0,3]
["S7143","LGK-974","a7","L3000-27","in 10mM DMSO","PORCN","Stem Cells & Wnt","LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.",396.44,"1243244-14-5",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://selleckchem.com/products/lgk-974.html","C23H20N6O","free base","NVP-LGK974, WNT974","CC1=CC(=CC=N1)C2=C(C)C=C(CC(=O)NC3=CC=C(C=N3)C4=CN=CC=N4)C=N2",2.098,6,1,5]
["S7144","BMS-911543","b7","L3000-27","in 10mM DMSO","JAK","JAK/STAT","BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.",432.52,"1271022-90-2",{"v":36,"d":"36.00"},83.23,"<1","N/A","http://selleckchem.com/products/bms-911543.html","C23H28N8O","free base","N/A","CC[N]1C(=CC2=C1N=C(NC3=N[N](C)C(=C3)C)C4=C2[N](C)C=N4)C(=O)N(C5CC5)C6CC6",3.556,4,1,6]
["S7145","AZD1080","c7","L3000-27","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.",334.37,"612487-72-6",{"v":52,"d":"52.00"},155.52,"<1","N/A","http://selleckchem.com/products/azd1080.html","C19H18N4O2","free base","N/A","OC1=C(C2=CC=C(CN3CCOCC3)C=N2)C4=CC(=CC=C4[NH]1)C#N",2.442,2,2,3]
["S7146","DMH1","d7","L3000-27","in 10mM DMSO","Autophagy,TGF-beta/Smad","TGF-beta/Smad","DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy.",380.44,"1206711-16-1",{"v":22,"d":"22.00"},57.83,"<1","N/A","http://selleckchem.com/products/dmh1.html","C24H20N4O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CC=NC5=C4C=CC=C5",4.036,4,0,4]
["S7147","LDN-212854","e7","L3000-27","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LDN-212854 (BMP Inhibitor III) is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.",406.48,"1432597-26-6",{"v":81,"d":"81.00"},199.27,"<1","N/A","http://selleckchem.com/products/ldn-212854.html","C25H22N6","free base","BMP Inhibitor III","C1CN(CCN1)C2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=CC6=C5C=CC=N6",2.909,3,1,3]
["S7148","ML347","f7","L3000-27","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","ML347 (LDN-193719) is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM.",352.39,"1062368-49-3",{"v":10,"d":"10.00"},28.38,"<1","N/A","http://selleckchem.com/products/ml347.html","C22H16N4O","free base","LDN-193719","COC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CC=CC5=C4C=CC=N5",3.309,4,0,3]
["S7149","NSC 319726","g7","L3000-27","in 10mM DMSO","p53","Apoptosis","NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.",234.32,"71555-25-4",{"v":19,"d":"19.00"},81.09,"<1","N/A","http://selleckchem.com/products/nsc319726.html","C11H14N4S","free base","N/A","CC(=N\\NC(=S)N1CCC1)/C2=NC=CC=C2",1.906,2,1,4]
["S7152","C646","h7","L3000-27","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy.",445.42,"328968-36-1",{"v":13,"d":"13.00"},29.19,"<1","N/A","http://selleckchem.com/products/c646.html","C24H19N3O6","free base","N/A","CC1=C(C)C=C(C(=C1)C2=CC=C(O2)\\C=C/3C(=NN(C3=O)C4=CC=C(C=C4)C(O)=O)C)[N+]([O-])=O",4.736,4,0,5]
["S7153","10058-F4","a8","L3000-27","in 10mM DMSO","Apoptosis related,Autophagy,Myc","Cell Cycle","10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 promotes a caspase-3-dependent apoptosis and modulates autophagy.",249.35,"403811-55-2",{"v":49,"d":"49.00"},196.51,"<1","N/A","http://selleckchem.com/products/10058-f4.html","C12H11NOS2","free base","N/A","CCC1=CC=C(C=C1)\\C=C/2SC(=S)NC2=O",3.783,1,1,2]
["S7155","Batimastat (BB-94)","b8","L3000-27","in 10mM DMSO","MMP","Proteases","Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.",477.64,"130370-60-4",{"v":96,"d":"96.00"},200.99,"<1","N/A","http://selleckchem.com/products/bb-94.html","C23H31N3O4S2","free base","N/A","CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)C(CSC2=CC=CS2)C(=O)NO",3.218,3,3,12]
["S7156","Marimastat (BB-2516)","c8","L3000-27","in 10mM DMSO","MMP","Proteases","Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.",331.41,"154039-60-8",{"v":54,"d":"54.00"},162.94,"<1","N/A","http://selleckchem.com/products/marimastat.html","C15H29N3O5","free base","TA2516","CNC(=O)C(NC(=O)C(CC(C)C)C(O)C(=O)NO)C(C)(C)C",0.239,3,4,8]
["S7157","Ilomastat","d8","L3000-27","in 10mM DMSO","MMP","Proteases","Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.",388.46,"142880-36-2",{"v":78,"d":"78.00"},200.79,"<1","N/A","http://selleckchem.com/products/gm6001.html","C20H28N4O4","free base","GM6001, Galardin","CNC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CC(C)C)CC(=O)NO",1.624,3,4,9]
["S7158","Abemaciclib mesylate (LY2835219)","e8","L3000-27","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.",{"v":602.7,"d":"602.70"},"1231930-82-7",{"v":83,"d":"83.00"},137.71,{"v":100,"d":"100.00"},165.92,"http://selleckchem.com/products/ly2835219.html","C27H32F2N8.CH4O3S","mesylate","N/A","CCN1CCN(CC1)CC2=CC=C(NC3=NC(=C(F)C=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)N=C2.C[S](O)(=O)=O",4.543,4,1,7]
["S7160","Glasdegib (PF-04449913)","f8","L3000-27","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.",374.44,"1095173-27-5",{"v":47,"d":"47.00"},125.52,"<1","N/A","http://selleckchem.com/products/glasdegib-pf-04449913.html","C21H22N6O","Free Base","N/A","CN1CCC(CC1C2=NC3=CC=CC=C3[NH]2)NC(=O)NC4=CC=C(C=C4)C#N",2.363,2,3,3]
["S7161","Motolimod (VTX-2337)","g8","L3000-27","in 10mM DMSO","TLR","Immunology & Inflammation","Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.",{"v":458.6,"d":"458.60"},"926927-61-9",{"v":55,"d":"55.00"},119.93,"<1","N/A","http://selleckchem.com/products/motolimod-vtx-2337.html","C28H34N4O2","free base","N/A","CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(N)C1",3.854,3,1,7]
["S7162","Mdivi-1","h8","L3000-27","in 10mM DMSO","Apoptosis related,Dynamin,Mitophagy","Cytoskeletal Signaling","Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.",353.22,"338967-87-6",{"v":70,"d":"70.00"},198.18,"<1","N/A","http://selleckchem.com/products/mdivi-1.html","C15H10Cl2N2O2S","free base","Mitochondrial division inhibitor 1","COC1=C(Cl)C=C(Cl)C(=C1)N2C(=NC3=C(C=CC=C3)C2=O)S",4.943,3,0,2]
["S7165","UNC1999","a9","L3000-27","in 10mM DMSO","Apoptosis related,Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.",569.74,"1431612-23-5",{"v":50,"d":"50.00"},87.76,"<1","N/A","http://selleckchem.com/products/unc1999.html","C33H43N7O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(CC5)C(C)C)C(=O)NC(=C1)C",4.629,4,2,9]
["S7167","SSR128129E","b9","L3000-27","in 10mM DMSO","FGFR","Angiogenesis","SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.",346.31,"848318-25-2",{"v":69,"d":"69.00"},199.24,{"v":1,"d":"1.00"},2.89,"http://selleckchem.com/products/ssr128129e.html","C18H15N2O4.Na","free base","SSR","COC1=C2C=CC=C[N]2C(=C1C)C(=O)C3=CC=C(N)C(=C3)C(=O)O[Na]",2.802,4,1,5]
["S7169","Crenigacestat (LY3039478)","c9","L3000-27","in 10mM DMSO","Gamma-secretase,Notch","Stem Cells & Wnt","Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.",464.44,"1421438-81-4",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/ly3039478.html","C22H23F3N4O4","free base","N/A","CC(NC(=O)CCC(F)(F)F)C(=O)NC1C(=O)N(CCO)C2=C(C=CC=N2)C3=C1C=CC=C3",1.395,4,3,8]
["S7170","Avutometinib","d9","L3000-27","in 10mM DMSO","MEK,Raf","MAPK","Avutometinib(RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.",471.46,"946128-88-7",{"v":94,"d":"94.00"},199.38,"<1","N/A","http://selleckchem.com/products/ro5126766-ch5126766.html","C21H18FN5O5S","free base","RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304","CN[S](=O)(=O)NC1=NC=CC(=C1F)CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O",2.473,8,2,7]
["S7173","Spebrutinib (CC-292)","e9","L3000-27","in 10mM DMSO","BTK","Angiogenesis","Spebrutinib (CC-292, AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.",423.44,"1202757-89-8",{"v":85,"d":"85.00"},200.74,"<1","N/A","http://selleckchem.com/products/avl-292.html","C22H22FN5O3","free base","AVL-292","COCCOC1=CC=C(NC2=NC=C(F)C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)C=C1",4.087,5,3,10]
["S7174","Opaganib (ABC294640)","f9","L3000-27","in 10mM DMSO","SPHK","Immunology & Inflammation","Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.",380.91,"915385-81-8",{"v":76,"d":"76.00"},199.52,"<1","N/A","http://selleckchem.com/products/abc294640.html","C23H25ClN2O","free base","N/A","ClC1=CC=C(C=C1)[C]23CC4[CH2]C(C[C](C4)(C2)C(=O)NCC5=CC=NC=C5)C3",4.265,2,1,4]
["S7176","SKI II","g9","L3000-27","in 10mM DMSO","SPHK","Immunology & Inflammation","SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.",302.78,"312636-16-1",{"v":61,"d":"61.00"},201.47,"<1","N/A","http://selleckchem.com/products/ski-ii.html","C15H11ClN2OS","free base","SphK-I2","OC1=CC=C(NC2=NC(=CS2)C3=CC=C(Cl)C=C3)C=C1",4.746,1,2,3]
["S7177","PF-543 hydrochloride","h9","L3000-27","in 10mM DMSO","Apoptosis related,Autophagy,SPHK","Immunology & Inflammation","PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.",502.07,"1706522-79-3",{"v":93,"d":"93.00"},185.23,"<1","N/A","http://selleckchem.com/products/pf-543.html","C27H32ClNO4S","hydrochloride","N/A","Cl.CC1=CC(=CC(=C1)C[S;v6](=O)(=O)C2=CC=CC=C2)OCC3=CC=C(CN4CCCC4CO)C=C3",5.016,3,1,9]
["S7179","Siponimod (BAF312)","a10","L3000-27","in 10mM DMSO","S1P Receptor","GPCR & G Protein","BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.",{"v":516.6,"d":"516.60"},"1230487-00-9",{"v":100,"d":"100.00"},193.57,"<1","N/A","http://selleckchem.com/products/baf312-siponimod.html","C29H35F3N2O3","free base","N/A","CCC1=CC(=CC=C1CN2CC(C2)C(O)=O)\\C(C)=N\\OCC3=CC=C(C4CCCCC4)C(=C3)C(F)(F)F",3.834,3,0,10]
["S7182","JTE 013","b10","L3000-27","in 10mM DMSO","S1P Receptor","GPCR & G Protein","JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.",408.29,"383150-41-2",{"v":81,"d":"81.00"},198.39,"<1","N/A","http://selleckchem.com/products/jte-013.html","C17H19Cl2N7O","free base","N/A","CC(C)C1=C2C(=N[N](C)C2=NC(=C1)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C",4.055,4,3,4]
["S7185","AGI-5198","c10","L3000-27","in 10mM DMSO","Dehydrogenase","Metabolism","AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.",462.56,"1355326-35-0",{"v":24,"d":"24.00"},51.89,"<1","N/A","http://selleckchem.com/products/agi-5198.html","C27H31FN4O2","free base","IDH-C35","CC1=C(C=CC=C1)C(N(C(=O)C[N]2C=CN=C2C)C3=CC(=CC=C3)F)C(=O)NC4CCCCC4",4.354,3,1,7]
["S7188","CID755673","d10","L3000-27","in 10mM DMSO","CaMK,PKD","Apoptosis","CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.",217.22,"521937-07-5",{"v":43,"d":"43.00"},196.13,"<1","N/A","http://selleckchem.com/products/cid755673.html","C12H11NO3","free base","N/A","OC1=CC2=C(OC3=C2CCCNC3=O)C=C1",1.922,2,2,0]
["S7189","Molibresib (I-BET-762)","e10","L3000-27","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.",{"v":423.9,"d":"423.90"},"1260907-17-2",{"v":84,"d":"84.00"},198.16,"<1","N/A","http://selleckchem.com/products/i-bet-762.html","C22H22ClN5O2","free base","GSK525762, GSK525762A","CCNC(=O)CC1N=C(C2=CC=C(Cl)C=C2)C3=CC(=CC=C3[N]4C(=NN=C14)C)OC",3.288,5,1,5]
["S7193","1-Azakenpaullone","f10","L3000-27","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","1-Azakenpaullone (1-Akp) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.",328.16,"676596-65-9",{"v":66,"d":"66.00"},201.12,"<1","N/A","http://selleckchem.com/products/1-azakenpaullone.html","C15H10BrN3O","free base","1-Akp","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3N=CC=C4)C=C1",2.949,2,2,0]
["S7194","Olverembatinib dimesylate (HQP1351)","g10","L3000-27","in 10mM DMSO","Bcr-Abl","Angiogenesis","Olverembatinib dimesylate (HQP1351, GZD824) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.",724.77,"1421783-64-3",{"v":100,"d":"100.00"},137.97,{"v":100,"d":"100.00"},137.97,"http://selleckchem.com/products/gzd824.html","C29H27F3N6O.2CH4O3S","Mesylate","GZD824 Dimesylate","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CC5=C([NH]N=C5)N=C4)C=C2)C(F)(F)F.C[S](O)(=O)=O.C[S](O)(=O)=O",4.047,3,2,7]
["S7195","RKI-1447","h10","L3000-27","in 10mM DMSO","ROCK","Cell Cycle","RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.",326.37,"1342278-01-6",{"v":65,"d":"65.00"},199.16,"<1","N/A","http://selleckchem.com/products/rki-1447.html","C16H14N4O2S","free base","N/A","OC1=CC(=CC=C1)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3",2.081,3,3,4]
["S7198","BIO","a11","L3000-27","in 10mM DMSO","Apoptosis related,CDK,GSK-3,JAK","PI3K/Akt/mTOR","BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.",356.17,"667463-62-9",{"v":71,"d":"71.00"},199.34,"<1","N/A","http://selleckchem.com/products/bio.html","C16H10BrN3O2","free base","GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052","O\\N=C/1\\C(NC2=CC=CC=C12)=C3\\C(=O)NC4=C3C=CC(=C4)Br",2.692,2,2,0]
["S7199","DBeQ","b11","L3000-27","in 10mM DMSO","p97","Ubiquitin","DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.",340.42,"177355-84-9",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://selleckchem.com/products/dbeq.html","C22H20N4","free base","JRF 12","C(NC1=NC2=CC=CC=C2C(=N1)NCC3=CC=CC=C3)C4=CC=CC=C4",5.232,2,2,6]
["S7205","Idasanutlin (RG-7388)","c11","L3000-27","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7206","CNX-2006","d11","L3000-27","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.",545.53,"1375465-09-0",{"v":100,"d":"100.00"},183.31,"<1","N/A","http://selleckchem.com/products/cnx-2006.html","C26H27F4N7O2","free base","N/A","COC1=C(NC2=NC=C(C(=N2)NC3=CC=CC(=C3)NC(=O)C=C)C(F)(F)F)C=CC(=C1)NC4CN(CCF)C4",{"v":5.15,"d":"5.150"},4,4,12]
["S7207","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","e11","L3000-27","in 10mM DMSO","PKC","TGF-beta/Smad","Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.",553.65,"138489-18-6",{"v":100,"d":"100.00"},180.62,"<1","N/A","http://selleckchem.com/products/ro-31-8220-mesylate.html","C25H23N5O2S.CH4O3S","Mesylate","Bisindolylmaleimide IX Mesylate","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](CCCSC(N)=N)C5=CC=CC=C45.C[S](O)(=O)=O",3.452,2,2,7]
["S7208","Bisindolylmaleimide I (GF109203X)","f11","L3000-27","in 10mM DMSO","PKC","TGF-beta/Smad","Bisindolylmaleimide I (GF109203X, GO 6850) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.",412.48,"133052-90-1",{"v":82,"d":"82.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/gf109203x.html","C25H24N4O2","free base","GO 6850","CN(C)CCC[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[NH]C5=CC=CC=C45",3.557,2,2,6]
["S7209","GSK650394","g11","L3000-27","in 10mM DMSO","SGK","Metabolism","GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.",382.45,"890842-28-1",{"v":76,"d":"76.00"},198.72,"<1","N/A","http://selleckchem.com/products/gsk650394.html","C25H22N2O2","free base","N/A","OC(=O)C1=C(C=C(C=C1)C2=C[NH]C3=NC=C(C=C23)C4=CC=CC=C4)C5CCCC5",5.573,2,1,4]
["S7211","PF-04418948","h11","L3000-27","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.",409.41,"1078166-57-0",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/pf-04418948.html","C23H20FNO5","free base","N/A","COC1=CC=C2C=C(OCC3(CN(C3)C(=O)C4=CC=C(F)C=C4)C(O)=O)C=CC2=C1",3.298,4,0,6]
["S7213","Thiamet G","a2","L3000-28","in 10mM DMSO","OGA","Autophagy","Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.",{"v":248.3,"d":"248.30"},"1009816-48-1",{"v":50,"d":"50.00"},201.37,{"v":50,"d":"50.00"},201.37,"http://selleckchem.com/products/thiamet-g.html","C9H16N2O4S","free base","N/A","CCNC1=NC2C(O)C(O)C(CO)OC2S1",-0.613,2,4,3]
["S7214","Skepinone-L","b2","L3000-28","in 10mM DMSO","p38 MAPK","MAPK","Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.",425.42,"1221485-83-1",{"v":85,"d":"85.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/skepinone-l.html","C24H21F2NO4","free base","CBS3830","OCC(O)COC1=CC=C2CCC3=CC(=CC=C3C(=O)C2=C1)NC4=CC=C(F)C=C4F",4.729,2,3,6]
["S7215","Losmapimod (GW856553X)","c2","L3000-28","in 10mM DMSO","Apoptosis related,Autophagy,p38 MAPK","MAPK","Losmapimod (GW856553X, GW856553, GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. P38 MAPKs are involved in cell differentiation, apoptosis and autophagy. Phase 3.",383.46,"585543-15-3",{"v":76,"d":"76.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/losmapimod-gw856553x.html","C22H26FN3O2","free base","GW856553, GSK-AHAB","CC1=C(F)C=C(C=C1C2=CC=C(C=N2)C(=O)NCC(C)(C)C)C(=O)NC3CC3",3.689,3,2,6]
["S7217","OAC1","d2","L3000-28","in 10mM DMSO","OCT","Stem Cells & Wnt","OAC1 (Oct4-activating compound 1, BAS 00287861) can enhance the efficiency of reprogramming. OAC1 can activate both Oct4 and Nanog promoter-driven luciferase reporter genes.",237.26,"300586-90-7",{"v":47,"d":"47.00"},198.09,"<1","N/A","http://selleckchem.com/products/oac1.html","C14H11N3O","free base","BAS 00287861","O=C(NC1=CC2=C([NH]C=C2)C=N1)C3=CC=CC=C3",2.296,2,2,2]
["S7218","Alvelestat (AZD9668)","e2","L3000-28","in 10mM DMSO","Serine Protease","Proteases","Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.\n\n Phase 2.",545.53,"848141-11-7",{"v":100,"d":"100.00"},183.31,"<1","N/A","http://selleckchem.com/products/avelestat-azd9668.html","C25H22F3N5O4S","free base","Avelestat","C[N]1N=CC=C1C2=CN(C(=O)C(=C2)C(=O)NCC3=NC=C(C=C3)[S](C)(=O)=O)C4=CC=CC(=C4)C(F)(F)F",2.163,6,1,7]
["S7223","RepSox (E-616452)","f2","L3000-28","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.",287.32,"446859-33-2",{"v":57,"d":"57.00"},198.39,"<1","N/A","http://selleckchem.com/products/repsox.html","C17H13N5","free base","SJN 2511,ALK5 Inhibitor II","CC1=CC=CC(=N1)C2=N[NH]C=C2C3=CC=C4N=CC=CC4=N3",3.192,4,1,2]
["S7224","Deltarasin","g2","L3000-28","in 10mM DMSO","PDE,Ras","Metabolism","Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.",603.75,"1440898-61-2",{"v":100,"d":"100.00"},165.63,"<1","N/A","http://selleckchem.com/products/deltarasin.html","C40H37N5O","free base","N/A","C1CC(CCN1)C(COC2=CC=C(C=C2)C3=NC4=C(C=CC=C4)[N]3CC5=CC=CC=C5)[N]6C7=CC=CC=C7N=C6C8=CC=CC=C8",{"v":8.52,"d":"8.520"},3,1,9]
["S7229","RGFP966","h2","L3000-28","in 10mM DMSO","HDAC","Epigenetics","RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.",{"v":362.4,"d":"362.40"},"1396841-57-8",{"v":72,"d":"72.00"},198.68,"<1","N/A","http://selleckchem.com/products/rgfp966.html","C21H19FN4O","free base","N/A","NC1=CC(=CC=C1NC(=O)\\C=C\\C2=C[N](C\\C=C\\C3=CC=CC=C3)N=C2)F",3.242,2,2,6]
["S7230","UNC0642","a3","L3000-28","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.",{"v":546.7,"d":"546.70"},"1481677-78-4",{"v":100,"d":"100.00"},182.92,"<1","N/A","http://selleckchem.com/products/unc0642.html","C29H44F2N6O2","free base","N/A","COC1=CC2=C(C=C1OCCCN3CCCC3)N=C(N=C2NC4CCN(CC4)C(C)C)N5CCC(F)(F)CC5",4.706,4,1,10]
["S7231","GSK2801","b3","L3000-28","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively.",371.45,"1619994-68-1",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://selleckchem.com/products/gsk2801.html","C20H21NO4S","free base","N/A","CCCOC1=CC2=C(C=C([N]2C=C1)C(C)=O)C3=C(C=CC=C3)[S](C)(=O)=O",3.594,4,0,6]
["S7233","Bromosporine","c3","L3000-28","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.",404.44,"1619994-69-2",{"v":81,"d":"81.00"},200.28,"<1","N/A","http://selleckchem.com/products/bromosporine.html","C17H20N6O4S","free base","N/A","CCOC(=O)NC1=CC(=N[N]2C(=NN=C12)C)C3=CC(=C(C)C=C3)N[S](C)(=O)=O",{"v":1.57,"d":"1.570"},7,2,6]
["S7234","IOX1","d3","L3000-28","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 is an inhibitor of ALKBH5.",189.17,"5852-78-8",{"v":37,"d":"37.00"},195.59,"<1","N/A","http://selleckchem.com/products/iox1.html","C10H7NO3","free base","N/A","OC(=O)C1=CC=C(O)C2=NC=CC=C12",1.404,2,1,1]
["S7237","OG-L002","e3","L3000-28","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.",225.29,"1357302-64-7",{"v":45,"d":"45.00"},199.74,"<1","N/A","http://selleckchem.com/products/og-l002.html","C15H15NO","free base","N/A","NC1CC1C2=CC=C(C=C2)C3=CC=CC(=C3)O",{"v":2.47,"d":"2.470"},0,2,2]
["S7238","NVP-TNKS656","f3","L3000-28","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NVP-TNKS656 is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.",494.58,"1419949-20-4",{"v":100,"d":"100.00"},202.19,"<1","N/A","http://selleckchem.com/products/nvp-tnks656.html","C27H34N4O5","free base","N/A","COC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)N(CC3CC3)CC4=NC5=C(COCC5)C(=O)N4",1.014,6,1,9]
["S7239","G007-LK","g3","L3000-28","in 10mM DMSO","PARP","DNA Damage/DNA Repair","G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.",529.96,"1380672-07-0",{"v":100,"d":"100.00"},188.69,"<1","N/A","http://selleckchem.com/products/g007-lk.html","C25H16ClN7O3S","free base","N/A","C[S](=O)(=O)C1=CN=C(C=C1)C2=NN=C(\\C=C\\C3=NN=C(O3)C4=CC=C(C=C4)C#N)[N]2C5=CC=CC=C5Cl",4.347,8,0,6]
["S7241","AGI-6780","h3","L3000-28","in 10mM DMSO","Dehydrogenase","Metabolism","AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.",481.51,"1432660-47-3",{"v":96,"d":"96.00"},199.37,"<1","N/A","http://selleckchem.com/products/agi-6780.html","C21H18F3N3O3S2","free base","N/A","FC(F)(F)C1=CC(=CC=C1)NC(=O)NC2=C(C=CC(=C2)[S](=O)(=O)NC3CC3)C4=CSC=C4",4.046,3,3,7]
["S7243","Ferrostatin-1 (Fer-1)","a4","L3000-28","in 10mM DMSO","Ferroptosis","Metabolism","Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.",262.35,"347174-05-4",{"v":52,"d":"52.00"},198.21,"<1","N/A","https://www.selleckchem.com/products/ferrostatin-1.html","C15H22N2O2","free base","N/A","CCOC(=O)C1=CC=C(NC2CCCCC2)C(=C1)N",2.954,2,2,5]
["S7248","Ro3280","b4","L3000-28","in 10mM DMSO","PLK","Cell Cycle","RO3280 (Ro5203280) is a potent, highly selective inhibitor of  Polo-like kinase 1 (PLK1) with IC50 of 3 nM.",543.61,"1062243-51-9",{"v":100,"d":"100.00"},183.96,"<1","N/A","http://selleckchem.com/products/ro3280.html","C27H35F2N7O3","free base","Ro5203280","COC1=C(NC2=NC3=C(C=N2)N(C)C(=O)C(F)(F)CN3C4CCCC4)C=CC(=C1)C(=O)NC5CCN(C)CC5",3.245,5,2,6]
["S7251","KPT-276","c4","L3000-28","in 10mM DMSO","CRM1","Transmembrane Transporters","KPT-276 is an orally bioavailable selective CRM1 inhibitor.",426.26,"1421919-75-6",{"v":20,"d":"20.00"},46.92,"<1","N/A","http://selleckchem.com/products/kpt-276.html","C16H10F8N4O","free base","N/A","FC1(F)CN(C1)C(=O)\\C=C/[N]2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F",3.025,3,0,5]
["S7252","Selinexor (KPT-330)","d4","L3000-28","in 10mM DMSO","CRM1","Transmembrane Transporters","Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.",443.31,"1393477-72-9",{"v":88,"d":"88.00"},198.51,"<1","N/A","http://selleckchem.com/products/kpt-330.html","C17H11F6N7O","free base","ATG-010","FC(F)(F)C1=CC(=CC(=C1)C2=N[N](\\C=C/C(=O)NNC3=CN=CC=N3)C=N2)C(F)(F)F",2.345,5,2,7]
["S7253","AZD2858","e4","L3000-28","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.",453.52,"486424-20-8",{"v":7,"d":"7.00"},15.43,"<1","N/A","http://selleckchem.com/products/azd2858.html","C21H23N7O3S","free base","N/A","CN1CCN(CC1)[S](=O)(=O)C2=CC=C(C=C2)C3=CN=C(N)C(=N3)C(=O)NC4=CN=CC=C4",0.405,6,2,5]
["S7255","Onvansertib (NMS-P937)","f4","L3000-28","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.",532.52,"1034616-18-6",{"v":42,"d":"42.00"},78.87,"<1","N/A","http://selleckchem.com/products/nms-p937-nms1286937.html","C24H27F3N8O3","free base","PCM-075, NMS1286937","CN1CCN(CC1)C2=CC=C(OC(F)(F)F)C(=C2)NC3=NC4=C(CCC5=C4[N](CCO)N=C5C(N)=O)C=N3",4.742,5,3,8]
["S7256","SGC-CBP30","g4","L3000-28","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.",509.04,"1613695-14-9",{"v":100,"d":"100.00"},196.45,"<1","N/A","http://selleckchem.com/products/sgc-cbp30.html","C28H33ClN4O3","free base","N/A","COC1=C(Cl)C=C(CCC2=NC3=CC(=CC=C3[N]2CC(C)N4CCOCC4)C5=C(C)ON=C5C)C=C1",{"v":5.22,"d":"5.220"},5,0,8]
["S7257","CNX-774","h4","L3000-28","in 10mM DMSO","BTK","Angiogenesis","CNX-774 is an irreversible, orally active, and highly selective BTK inhibitor with IC50 of <1 nM.",{"v":499.5,"d":"499.50"},"1202759-32-7",{"v":100,"d":"100.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://selleckchem.com/products/cnx-774.html","C26H22FN7O3","free base","N/A","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC3=NC(=C(F)C=N3)NC4=CC=CC(=C4)NC(=O)C=C)C=C2",4.281,6,4,9]
["S7258","SKLB1002","a5","L3000-28","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.",320.39,"1225451-84-2",{"v":7,"d":"7.00"},21.85,"<1","N/A","http://selleckchem.com/products/sklb1002.html","C13H12N4O2S2","free base","N/A","COC1=C(OC)C=C2C(=NC=NC2=C1)SC3=NN=C(C)S3",2.747,6,0,4]
["S7259","FLLL32","b5","L3000-28","in 10mM DMSO","IFN,Interleukins,JAK","JAK/STAT","FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.",464.55,"1226895-15-3",{"v":92,"d":"92.00"},198.04,"<1","N/A","http://selleckchem.com/products/flll32.html","C28H32O6","free base","N/A","COC1=CC=C(/C=C/C(=O)C2(CCCCC2)C(=O)\\C=C\\C3=CC(=C(OC)C=C3)OC)C=C1OC",5.882,6,0,10]
["S7261","Beta-Lapachone","c5","L3000-28","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.",242.27,"4707-32-8",{"v":33,"d":"33.00"},136.21,"<1","N/A","http://selleckchem.com/products/beta-lapachone.html","C15H14O3","free base","β-Lapachone, ARQ-501","CC1(C)CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O",2.509,3,0,0]
["S7262","Vidofludimus","d5","L3000-28","in 10mM DMSO","COVID-19,Dehydrogenase","Metabolism","Vidofludimus (SC12267, 4SC-101) is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.",355.36,"717824-30-1",{"v":100,"d":"100.00"},{"v":281.4,"d":"281.40"},"<1","N/A","http://selleckchem.com/products/vidofludimus.html","C20H18FNO4","free base","SC12267, 4SC-101","COC1=CC(=CC=C1)C2=CC(=C(NC(=O)C3=C(CCC3)C(O)=O)C=C2)F",3.878,3,1,5]
["S7263","AZD1981","e5","L3000-28","in 10mM DMSO","GPR","Endocrinology & Hormones","AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.",388.87,"802904-66-1",{"v":11,"d":"11.00"},28.29,"<1","N/A","http://selleckchem.com/products/azd1981.html","C19H17ClN2O3S","free base","N/A","CC(=O)NC1=C2C(=CC=C1)[N](CC(O)=O)C(=C2SC3=CC=C(Cl)C=C3)C",3.859,2,1,5]
["S7265","MM-102","f5","L3000-28","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1  protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM.",{"v":669.8,"d":"669.80"},"1417329-24-8",{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},"http://selleckchem.com/products/mm-102.html","C35H49F2N7O4","free base","HMTase Inhibitor IX","CCC(CC)(NC(=O)C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3",4.419,4,6,17]
["S7266","Golgicide A","g5","L3000-28","in 10mM DMSO","ATPase","Transmembrane Transporters","Golgicide A is a potent and rapidly reversible GBF1 inhibitor.",{"v":284.3,"d":"284.30"},"1139889-93-2",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/golgicide-a.html","C17H14F2N2","free base","N/A","FC1=CC2=C(NC(C3CC=CC23)C4=CN=CC=C4)C(=C1)F",3.253,1,1,1]
["S7269","PD173955","h5","L3000-28","in 10mM DMSO","Bcr-Abl","Angiogenesis","PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.",443.35,"260415-63-2",{"v":15,"d":"15.00"},33.83,"<1","N/A","http://selleckchem.com/products/pd173955.html","C21H16Cl2N4OS","free base","N/A","CSC1=CC(=CC=C1)NC2=NC3C(C=N2)C=C(C(=O)N3C)C4=C(Cl)C=CC=C4Cl",4.854,3,1,4]
["S7270","SRPIN340","a6","L3000-28","in 10mM DMSO","Serine/threonin kinase","Metabolism","SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..",349.35,"218156-96-8",{"v":70,"d":"70.00"},200.37,"<1","N/A","http://selleckchem.com/products/srpin340.html","C18H18F3N3O","free base","N/A","FC(F)(F)C1=CC(=C(C=C1)N2CCCCC2)NC(=O)C3=CC=NC=C3",3.485,2,1,4]
["S7271","FRAX597","b6","L3000-28","in 10mM DMSO","PAK","Cytoskeletal Signaling","FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.",{"v":558.1,"d":"558.10"},"1286739-19-2",{"v":14,"d":"14.00"},25.09,"<1","N/A","http://selleckchem.com/products/frax597.html","C29H28ClN7OS","free base","N/A","CCN1C(=O)C(=CC2=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N=C12)C5=CC=C(C=C5Cl)C6=CN=CS6",5.166,4,1,6]
["S7273","SC75741","c6","L3000-28","in 10mM DMSO","Influenza Virus,NF-κB","NF-κB","SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.",565.67,"913822-46-5",{"v":35,"d":"35.00"},61.87,"<1","N/A","http://selleckchem.com/products/sc75741.html","C29H23N7O2S2","free base","N/A","O=C(NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CC=C3)C4=CSC(=N4)C5CCN(CC5)C6=C7SC=CC7=NC=N6",{"v":5.57,"d":"5.570"},6,2,6]
["S7276","SGI-1027","d6","L3000-28","in 10mM DMSO","Apoptosis related,DNA Methyltransferase","Epigenetics","SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.",461.52,"1020149-73-8",{"v":92,"d":"92.00"},199.34,"<1","N/A","http://selleckchem.com/products/sgi-1027.html","C27H23N7O","free base","DNA Methyltransferase Inhibitor II","CC1=CC(=NC(=N1)N)NC2=CC=C(NC(=O)C3=CC=C(NC4=CC=NC5=C4C=CC=C5)C=C3)C=C2",4.718,4,4,6]
["S7278","HPOB","e6","L3000-28","in 10mM DMSO","HDAC","Cytoskeletal Signaling","HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs.",314.34,"1429651-50-2",{"v":62,"d":"62.00"},197.24,"<1","N/A","http://selleckchem.com/products/hpob.html","C17H18N2O4","free base","N/A","OCCN(C(=O)CC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",{"v":1.33,"d":"1.330"},2,2,6]
["S7280","Edoxaban tosylate Monohydrate","f6","L3000-28","in 10mM DMSO","Factor Xa","Metabolism","Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.",738.27,"1229194-11-9",{"v":100,"d":"100.00"},135.45,"<1","N/A","http://selleckchem.com/products/edoxaban.html","C24H30ClN7O4S.C7H8O3S.H2O","Tosylate hydrate","DU-176b","O.CN(C)C(=O)C1CCC(NC(=O)C(=O)NC2=CC=C(Cl)C=N2)C(C1)NC(=O)C3=NC4=C(CN(C)CC4)S3.CC5=CC=C(C=C5)[S](O)(=O)=O",2.286,6,3,7]
["S7281","JIB-04","g6","L3000-28","in 10mM DMSO","Apoptosis related,Histone Demethylase,JMJD","Epigenetics","JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.",308.76,"199596-05-9",{"v":25,"d":"25.00"},80.97,"<1","N/A","http://selleckchem.com/products/jib-04.html","C17H13ClN4","free base","NSC 693627","ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1",4.424,3,1,4]
["S7282","NMS-E973","h6","L3000-28","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.",454.43,"1253584-84-7",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/nms-e973.html","C22H22N4O7","free base","N/A","CN1CCC(CC1)NC(=O)C2=NOC(=C2)C3=C(OC4=CC=C(C=C4)[N+]([O-])=O)C=C(O)C=C3O",2.811,4,3,6]
["S7284","Rociletinib (CO-1686)","a7","L3000-28","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.",555.55,"1374640-70-6",{"v":100,"d":"100.00"},{"v":180,"d":"180.00"},"<1","N/A","http://selleckchem.com/products/co-1686.html","C27H28F3N7O3","free base","AVL-301","COC1=C(NC2=NC=C(C(=N2)NC3=CC=CC(=C3)NC(=O)C=C)C(F)(F)F)C=CC(=C1)N4CCN(CC4)C(C)=O",4.334,5,3,9]
["S7285","NMS-873","b7","L3000-28","in 10mM DMSO","p97","Ubiquitin","NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).",520.67,"1418013-75-8",{"v":100,"d":"100.00"},192.06,"<1","N/A","http://selleckchem.com/products/nms-873.html","C27H28N4O3S2","free base","N/A","CC1=CC(=CC=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3=NN=C(SC4CCCC4)[N]3C5=CN=CC=C5",5.602,6,0,8]
["S7289","PFK15","c7","L3000-28","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.",260.29,"4382-63-2",{"v":19,"d":"19.00"},{"v":73,"d":"73.00"},"<1","N/A","http://selleckchem.com/products/pfk15.html","C17H12N2O","free base","PFK-015","O=C(\\C=C\\C1=CC=C2C=CC=CC2=N1)C3=CC=NC=C3",3.166,3,0,3]
["S7291","TAK-632","d7","L3000-28","in 10mM DMSO","Raf","MAPK","TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.",554.52,"1228591-30-7",{"v":100,"d":"100.00"},180.34,"<1","N/A","http://selleckchem.com/products/tak-632.html","C27H18F4N4O3S","free base","N/A","FC1=C(NC(=O)CC2=CC=CC(=C2)C(F)(F)F)C=C(OC3=C(C#N)C4=C(C=C3)N=C(NC(=O)C5CC5)S4)C=C1",{"v":5.74,"d":"5.740"},4,2,8]
["S7292","RG2833 (RGFP109)","e7","L3000-28","in 10mM DMSO","HDAC","Epigenetics","RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3 in cell-free assays, respectively.",339.43,"1215493-56-3",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://selleckchem.com/products/rg2833-rgfp109.html","C20H25N3O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N",2.895,2,3,8]
["S7293","ZCL278","f7","L3000-28","in 10mM DMSO","Rho","Cell Cycle","ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.",584.89,"587841-73-4",{"v":100,"d":"100.00"},170.97,"<1","N/A","http://selleckchem.com/products/zcl278.html","C21H19BrClN5O4S2","free base","N/A","CC1=CC(=NC(=N1)N[S](=O)(=O)C2=CC=C(NC(=S)NC(=O)COC3=C(Cl)C=C(Br)C=C3)C=C2)C",4.809,6,3,9]
["S7294","PFI-2 HCl","g7","L3000-28","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.",535.98,"1627607-87-7",{"v":99,"d":"99.00"},184.71,{"v":4,"d":"4.00"},7.46,"http://selleckchem.com/products/pfi-2.html","C23H25F4N3O3S.HCl","Hydrochloride","N/A","FC1=CC(=CC2=C1CNCC2)[S](=O)(=O)NC(CC3=CC=CC(=C3)C(F)(F)F)C(=O)N4CCCC4",3.268,3,2,7]
["S7295","Apabetalone (RVX-208)","h7","L3000-28","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.",{"v":370.4,"d":"370.40"},"1044870-39-4",{"v":74,"d":"74.00"},199.78,"<1","N/A","http://selleckchem.com/products/rvx-208.html","C20H22N2O5","free base","RVX-000222","COC1=CC(=C2C(=O)NC(=NC2=C1)C3=CC(=C(OCCO)C(=C3)C)C)OC",2.877,5,2,6]
["S7296","ML324","a8","L3000-28","in 10mM DMSO","CMV,Histone Demethylase,JMJD","Epigenetics","ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.",349.43,"1222800-79-4",{"v":43,"d":"43.00"},123.06,"<1","N/A","http://selleckchem.com/products/ml324.html","C21H23N3O2","free base","N/A","CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC3=CC=CN=C3C(=C2)O",2.701,2,2,6]
["S7297","Osimertinib (AZD9291)","b8","L3000-28","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.",499.61,"1421373-65-0",{"v":99,"d":"99.00"},198.15,"<1","N/A","http://selleckchem.com/products/azd9291.html","C28H33N7O2","free base","Mereletinib","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",4.671,4,2,10]
["S7298","AZ5104","c8","L3000-28","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.",485.58,"1421373-98-9",{"v":97,"d":"97.00"},199.76,"<1","N/A","http://selleckchem.com/products/az5104.html","C27H31N7O2","free base","N/A","COC1=C(NC2=NC=CC(=N2)C3=C[NH]C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",4.465,4,3,10]
["S7300","PJ34 HCl","d8","L3000-28","in 10mM DMSO","PARP","DNA Damage/DNA Repair","PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.",{"v":331.8,"d":"331.80"},"344458-15-7",{"v":66,"d":"66.00"},198.92,{"v":66,"d":"66.00"},198.92,"http://selleckchem.com/products/pj34-hcl.html","C17H17N3O2.HCl","Hydrochloride","N/A","Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=C2C=CC=C3)C=C1",1.811,2,2,3]
["S7301","IWP-L6","e8","L3000-28","in 10mM DMSO","PORCN","Stem Cells & Wnt","IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.",472.58,"1427782-89-5",{"v":25,"d":"25.00"},{"v":52.9,"d":"52.90"},"<1","N/A","http://selleckchem.com/products/iwp-l6.html","C25H20N4O2S2","free base","Porcn Inhibitor III","O=C(CSC1=NC2=C(SCC2)C(=O)N1C3=CC=CC=C3)NC4=NC=C(C=C4)C5=CC=CC=C5",4.072,4,1,6]
["S7302","TEPP-46 (ML265)","f8","L3000-28","in 10mM DMSO","PKM","Metabolism","TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.",372.46,"1221186-53-3",{"v":74,"d":"74.00"},198.68,"<1","N/A","http://www.selleckchem.com/products/tepp-46.html","C17H16N4O2S2","Free Base","CID-44246499, NCGC00186528","C[N]1C2=C(SC(=C2)[S](C)=O)C3=C1C(=O)N(CC4=CC=CC(=C4)N)N=C3",2.194,3,1,3]
["S7303","Rilpivirine","g8","L3000-28","in 10mM DMSO","Reverse Transcriptase","Microbiology","Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.",366.42,"500287-72-9",{"v":73,"d":"73.00"},199.22,"<1","N/A","http://selleckchem.com/products/rilpivirine.html","C22H18N6","free base","R278474, TMC278, DB08864","CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N",5.409,2,2,5]
["S7304","CPI-203","h8","L3000-28","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","CPI-203 is a potent BET bromodomain inhibitor with IC50 of 37 nM for BRD4.",{"v":399.9,"d":"399.90"},"1446144-04-2",{"v":79,"d":"79.00"},197.55,"<1","N/A","http://selleckchem.com/products/cpi-203.html","C19H18ClN5OS","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(N)=O)N=C2C4=CC=C(Cl)C=C4)C",3.168,4,1,3]
["S7305","MS436","a9","L3000-28","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","MS436 is a selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively.",383.42,"1395084-25-9",{"v":55,"d":"55.00"},143.45,"<1","N/A","http://selleckchem.com/products/ms436.html","C18H17N5O3S","free base","N/A","CC1=C(O)C=C(N)C(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.573,5,3,5]
["S7307","GSK2606414","b9","L3000-28","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.",451.44,"1337531-36-8",{"v":90,"d":"90.00"},199.36,"<1","N/A","http://selleckchem.com/products/gsk2606414.html","C24H20F3N5O","free base","N/A","C[N]1C=C(C2=CC=C3N(CCC3=C2)C(=O)CC4=CC=CC(=C4)C(F)(F)F)C5=C1N=CN=C5N",4.103,3,1,4]
["S7309","BAY 87-2243","c9","L3000-28","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7310","SF1670","d9","L3000-28","in 10mM DMSO","PTEN","PI3K/Akt/mTOR","SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.",307.34,"345630-40-2",{"v":29,"d":"29.00"},94.36,"<1","N/A","http://selleckchem.com/products/sf1670.html","C19H17NO3","free base","N/A","CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=C(C=CC=C3)C(=O)C2=O",3.475,3,1,2]
["S7311","Q-VD-Oph","e9","L3000-28","in 10mM DMSO","Caspase,HIV","Apoptosis","Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.",513.49,"1135695-98-5",{"v":100,"d":"100.00"},194.75,"<1","N/A","http://selleckchem.com/products/q-vd-oph.html","C26H25F2N3O6","free base","Quinoline-Val-Asp-Difluorophenoxymethylketone","CC(C)C(NC(=O)C1=NC2=CC=CC=C2C=C1)C(=O)NC(CC(O)=O)C(=O)COC3=C(F)C=CC=C3F",3.397,6,2,11]
["S7312","Z-DEVD-FMK","f9","L3000-28","in 10mM DMSO","Caspase","Apoptosis","Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.",668.66,"210344-95-9",{"v":100,"d":"100.00"},149.55,"<1","N/A","http://selleckchem.com/products/z-devd-fmk.html","C30H41FN4O12","free base","Caspase-3 Inhibitor","COC(=O)CCC(CC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF",1.347,12,3,24]
["S7315","PFI-3","g9","L3000-28","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-3 is a selective chemical probe for SMARCA bromodomains, including SMARCA2, SMARCA4 and PB1(5) bromodomains.",321.37,"1819363-80-8",{"v":64,"d":"64.00"},199.15,"<1","N/A","http://selleckchem.com/products/pfi-3.html","C19H19N3O2","free base","N/A","OC1=CC=CC=C1C(=O)\\C=C\\N2CC3CC2CN3C4=NC=CC=C4",2.438,2,1,4]
["S7316","STF-118804","h9","L3000-28","in 10mM DMSO","NAMPT","Metabolism","STF-118804 is a highly specific NAMPT inhibitor.",461.53,"894187-61-2",{"v":61,"d":"61.00"},132.17,"<1","N/A","http://selleckchem.com/products/stf-118804.html","C25H23N3O4S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)CC2=C(C)OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4",3.249,6,1,7]
["S7317","WZ4003","a10","L3000-28","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.",496.99,"1214265-58-3",{"v":7,"d":"7.00"},14.08,"<1","N/A","http://selleckchem.com/products/wz4003.html","C25H29ClN6O3","free base","N/A","CCC(=O)NC1=CC=CC(=C1)OC2=NC(=NC=C2Cl)NC3=C(OC)C=C(C=C3)N4CCN(C)CC4",4.776,5,2,8]
["S7318","HTH-01-015","b10","L3000-28","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.",468.55,"1613724-42-7",{"v":58,"d":"58.00"},123.79,"<1","N/A","http://selleckchem.com/products/hth-01-015.html","C26H28N8O","free base","N/A","CN1C(=O)C2=C(C=C3C=CC=CC3=C2)N(C)C4=NC(=NC(=C14)C)NC5=C[N](N=C5)C6CCNCC6",2.993,4,2,3]
["S7319","EHop-016","c10","L3000-28","in 10mM DMSO","Rho","Cell Cycle","EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.",430.55,"1380432-32-5",{"v":86,"d":"86.00"},199.74,"<1","N/A","http://selleckchem.com/products/ehop-016.html","C25H30N6O","free base","N/A","CC[N]1C2=C(C=CC=C2)C3=C1C=CC(=C3)NC4=NC(=NC=C4)NCCCN5CCOCC5",4.407,3,2,8]
["S7320","TG003","d10","L3000-28","in 10mM DMSO","CDK","Cell Cycle","TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC.",249.33,"300801-52-9",{"v":6,"d":"6.00"},24.06,"<1","N/A","http://selleckchem.com/products/tg003.html","C13H15NO2S","free base","N/A","CCN1\\C(SC2=C1C=C(OC)C=C2)=C\\C(C)=O",3.024,2,0,3]
["S7324","TMP269","e10","L3000-28","in 10mM DMSO","HDAC","Epigenetics","TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.",514.52,"1314890-29-3",{"v":100,"d":"100.00"},194.36,"<1","N/A","http://selleckchem.com/products/tmp269.html","C25H21F3N4O3S","free base","N/A","FC(F)(F)C1=NC(=NO1)C2=CC=CC(=C2)C(=O)NCC3(CCOCC3)C4=NC(=CS4)C5=CC=CC=C5",4.311,6,1,7]
["S7326","Tasisulam","f10","L3000-28","in 10mM DMSO","Caspase","Apoptosis","Tasisulam (LY573636) is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.",415.11,"519055-62-0",{"v":83,"d":"83.00"},199.95,"<1","N/A","http://selleckchem.com/products/tasisulam.html","C11H6BrCl2NO3S2","free base","LY573636","ClC1=CC(=C(C=C1)C(=O)N[S](=O)(=O)C2=CC=C(Br)S2)Cl",3.872,3,1,3]
["S7327","ID-8","g10","L3000-28","in 10mM DMSO","DYRK","Cell Cycle","ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.",298.29,"147591-46-6",{"v":60,"d":"60.00"},201.15,"<1","N/A","http://selleckchem.com/products/id-8.html","C16H14N2O4","free base","N/A","COC1=CC=C(C=C1)[N]2C(=C(C3=C2C=C(O)C=C3)[N+]([O-])=O)C",3.687,1,1,3]
["S7329","IOWH032","h10","L3000-28","in 10mM DMSO","CFTR","Transmembrane Transporters","IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.",545.18,"1191252-49-9",{"v":100,"d":"100.00"},183.43,"<1","N/A","http://selleckchem.com/products/iowh032.html","C22H15Br2N3O4","free base","N/A","OC1=C(Br)C=C(C=C1Br)C2=NOC(=N2)C(=O)NCC3=CC=C(OC4=CC=CC=C4)C=C3",5.233,5,2,6]
["S7330","6H05","a11","L3000-28","in 10mM DMSO","Ras","Cell Cycle","6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).",590.14,"2061344-88-3",{"v":100,"d":"100.00"},169.45,{"v":100,"d":"100.00"},169.45,"http://selleckchem.com/products/6h05.html","C20H30ClN3O2S3.CF3COOH","free base","N/A","CN(C)CCSSCCNC(=O)C1CCN(CC1)C(=O)CSC2=CC=C(Cl)C=C2.OC(=O)C(F)(F)F",1.174,3,1,12]
["S7331","K-Ras(G12C) inhibitor 12","b11","L3000-28","in 10mM DMSO","Ras","Cell Cycle","K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).",449.67,"1469337-95-8",{"v":27,"d":"27.00"},60.04,"<1","N/A","http://selleckchem.com/products/k-ras-g12c-inhibitor-12.html","C15H17ClIN3O3","free base","N/A","OC1=CC(=C(I)C=C1NCC(=O)N2CCN(CC2)C(=O)C=C)Cl",1.819,2,2,4]
["S7332","K-Ras(G12C) inhibitor 9","c11","L3000-28","in 10mM DMSO","Ras","Cell Cycle","K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).",513.78,"1469337-91-4",{"v":53,"d":"53.00"},103.16,"<1","N/A","http://selleckchem.com/products/k-ras-g12c-inhibitor9.html","C16H21ClIN3O4S","free base","N/A","COC1=CC(=C(I)C=C1NCC(=O)N2CCC(CC2)N[S](=O)(=O)C=C)Cl",{"v":1.17,"d":"1.170"},4,2,7]
["S7333","K-Ras(G12C) inhibitor 6","d11","L3000-28","in 10mM DMSO","Ras","Cell Cycle","K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).",405.34,"2060530-16-5",{"v":81,"d":"81.00"},199.83,"<1","N/A","http://selleckchem.com/products/k-ras-g12c-inhibitor-6.html","C17H22Cl2N2O3S","free base","N/A","SCCCC(=O)NC1CCN(CC1)C(=O)COC2=CC=C(Cl)C=C2Cl",2.441,3,1,7]
["S7334","ERK5-IN-1","e11","L3000-28","in 10mM DMSO","ERK","MAPK","ERK5-IN-1 (XMD17-109) is a potent, and selective ERK5 inhibitor with IC50 of 162 nM.",638.81,"1435488-37-1",{"v":100,"d":"100.00"},156.54,"<1","N/A","http://selleckchem.com/products/erk5-in-1.html","C36H46N8O3","free base","XMD17-109","CCOC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C5CCCC5)C3=N2)C=CC(=C1)C(=O)N6CCC(CC6)N7CCN(C)CC7",4.794,5,1,7]
["S7336","CW069","f11","L3000-28","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.",500.33,"1594094-64-0",{"v":100,"d":"100.00"},199.87,"<1","N/A","http://selleckchem.com/products/cw069.html","C23H21IN2O3","free base","N/A","OC(=O)C1=CC(=CC=C1NC(=O)C(CC2=CC=CC=C2)NCC3=CC=CC=C3)I",1.547,2,2,8]
["S7337","SH-4-54","g11","L3000-28","in 10mM DMSO","STAT","JAK/STAT","SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.",610.59,"1456632-40-8",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/sh-4-54.html","C29H27F5N2O5S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(O)=O)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",6.221,4,0,9]
["S7338","AZ191","h11","L3000-28","in 10mM DMSO","DYRK","Protein Tyrosine Kinase","AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.",429.52,"1594092-37-1",{"v":85,"d":"85.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/az191.html","C24H27N7O","free base","N/A","COC1=CC(=CC=C1NC2=NC=CC(=N2)C3=C[N](C)C4=CN=CC=C34)N5CCN(C)CC5",3.521,4,1,5]
["S7339","AZD3965","a2","L3000-29","in 10mM DMSO","MCT","Transmembrane Transporters","AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.",515.51,"1448671-31-5",{"v":100,"d":"100.00"},193.98,"<1","N/A","http://selleckchem.com/products/azd3965.html","C21H24F3N5O5S","free base","N/A","CC(C)N1C(=O)N(C)C(=O)C2=C1SC(=C2C(=O)N3CC(C)(O)CO3)CC4=C(C)[NH]N=C4C(F)(F)F",2.066,5,1,5]
["S7340","CH5138303","b2","L3000-29","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.",{"v":415.9,"d":"415.90"},"959763-06-5",{"v":83,"d":"83.00"},199.57,"<1","N/A","http://selleckchem.com/products/ch5138303.html","C19H18ClN5O2S","free base","N/A","NC(=O)CCCSC1=NC(=NC(=N1)C2=C(Cl)C=C3COCC4=CC=CC2=C34)N",2.956,5,2,6]
["S7343","URMC-099","c2","L3000-29","in 10mM DMSO","Autophagy,Bcr-Abl,LRRK2,Mixed Lineage Kinase","MAPK","URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. URMC-099 also inhibits ABL1 with IC50 of 6.8 nM. URMC-099 induces autophagy.",421.54,"1229582-33-5",{"v":84,"d":"84.00"},199.27,"<1","N/A","http://selleckchem.com/products/urmc-099.html","C27H27N5","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C([NH]C=C4C5=CC=C6[NH]C=CC6=C5)N=C3",4.533,1,2,4]
["S7351","JSH-23","d2","L3000-29","in 10mM DMSO","NF-κB","NF-κB","JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.",240.34,"749886-87-1",{"v":48,"d":"48.00"},199.72,"<1","N/A","http://selleckchem.com/products/jsh-23.html","C16H20N2","free base","N/A","CC1=CC=C(NCCCC2=CC=CC=C2)C(=C1)N",3.739,0,2,5]
["S7352","Bay 11-7085","e2","L3000-29","in 10mM DMSO","IκB/IKK","NF-κB","BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.",249.33,"196309-76-9",{"v":50,"d":"50.00"},200.54,"<1","N/A","http://selleckchem.com/products/bay-11-7085.html","C13H15NO2S","free base","Bay 11-7083","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",2.635,2,0,3]
["S7353","EPZ004777","f2","L3000-29","in 10mM DMSO","Apoptosis related,DOT1,Histone Methyltransferase","Epigenetics","EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis.",539.67,"1338466-77-5",{"v":100,"d":"100.00"},{"v":185.3,"d":"185.30"},"<1","N/A","http://selleckchem.com/products/epz004777.html","C28H41N7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=CC4=C3N=CN=C4N",2.529,4,5,10]
["S7355","ARQ 621","g2","L3000-29","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.",552.43,"1095253-39-6",{"v":100,"d":"100.00"},181.02,"<1","N/A","http://selleckchem.com/products/arq-621.html","C28H24Cl2FN5O2","free base","N/A","NCCCN(C(CC#C)C1=NC2=C(C=CC(=C2)Cl)C(=O)N1NC3=CC=CC=C3)C(=O)C4=CC=CC(=C4F)Cl",{"v":5.98,"d":"5.980"},3,2,9]
["S7356","HS-173","h2","L3000-29","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM.",422.46,"1276110-06-5",{"v":84,"d":"84.00"},198.84,"<1","N/A","http://selleckchem.com/products/hs-173.html","C21H18N4O4S","free base","N/A","CCOC(=O)C1=CN=C2C=CC(=C[N]12)C3=CN=CC(=C3)N[S](=O)(=O)C4=CC=CC=C4",2.058,6,1,7]
["S7357","PF-562271 HCl","a3","L3000-29","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.",543.95,"939791-41-0",{"v":100,"d":"100.00"},183.84,"<1","N/A","http://selleckchem.com/products/pf-562271-hcl.html","C21H21ClF3N7O3S","Hydrochloride","N/A","Cl.CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O",2.873,6,3,8]
["S7358","Poziotinib (HM781-36B)","b3","L3000-29","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.",491.34,"1092364-38-9",{"v":98,"d":"98.00"},199.45,"<1","N/A","http://selleckchem.com/products/poziotinib-hm781-36b.html","C23H21Cl2FN4O3","free base","NOV120101","COC1=CC2=C(C=C1OC3CCN(CC3)C(=O)C=C)C(=NC=N2)NC4=CC=C(Cl)C(=C4F)Cl",5.046,5,1,6]
["S7359","K02288","c3","L3000-29","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.",352.38,"1431985-92-0",{"v":70,"d":"70.00"},198.65,"<1","N/A","http://selleckchem.com/products/k02288.html","C20H20N2O4","free base","N/A","COC1=CC(=CC(=C1OC)OC)C2=C(N)N=CC(=C2)C3=CC=CC(=C3)O",3.217,4,2,5]
["S7360","Birabresib (OTX015)","d3","L3000-29","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",491.99,"202590-98-5",{"v":98,"d":"98.00"},199.19,"<1","N/A","http://selleckchem.com/products/otx015.html","C25H22ClN5O2S","free base","MK 8628","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(O)C=C4)N=C2C5=CC=C(Cl)C=C5)C",4.709,4,2,4]
["S7367","GNE-0877","e3","L3000-29","in 10mM DMSO","LRRK2","Autophagy","GNE-0877 (DNL201) is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM.",339.32,"1374828-69-9",{"v":67,"d":"67.00"},197.45,"<1","N/A","http://selleckchem.com/products/gne-0877.html","C14H16F3N7","free base","DNL201","CNC1=NC(=NC=C1C(F)(F)F)NC2=C[N](N=C2C)C(C)(C)C#N",2.871,3,2,5]
["S7368","GNE-9605","f3","L3000-29","in 10mM DMSO","LRRK2","Autophagy","GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.",449.83,"1536200-31-3",{"v":89,"d":"89.00"},197.85,"<1","N/A","http://selleckchem.com/products/gne-9605.html","C17H20ClF4N7O","free base","N/A","CNC1=NC(=NC=C1C(F)(F)F)NC2=C(Cl)[N](N=C2)C3CCN(CC3F)C4COC4",2.715,4,2,6]
["S7369","4EGI-1","g3","L3000-29","in 10mM DMSO","Apoptosis related,eIF,mTOR","Cell Cycle","4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.",451.28,"315706-13-9",{"v":90,"d":"90.00"},199.43,"<1","N/A","http://selleckchem.com/products/4egi-1.html","C18H12Cl2N4O4S","free base","N/A","OC(=O)C(/CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(=CS2)C3=CC=C(Cl)C(=C3)Cl",5.397,3,1,7]
["S7370","4E1RCat","h3","L3000-29","in 10mM DMSO","eIF","Cell Cycle","4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.",478.45,"328998-25-0",{"v":96,"d":"96.00"},200.65,"<1","N/A","http://selleckchem.com/products/4e1rcat.html","C28H18N2O6","free base","N/A","OC(=O)C1=CC=C(C=C1)N2C(=O)\\C(=C\\C3=CC=C(O3)C4=CC=C(C=C4)[N+]([O-])=O)C=C2C5=CC=CC=C5",5.414,3,0,6]
["S7372","PTC-209","a4","L3000-29","in 10mM DMSO","BMI-1","Cell Cycle","PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).",495.19,"315704-66-6",{"v":99,"d":"99.00"},199.92,"<1","N/A","http://selleckchem.com/products/ptc-209.html","C17H13Br2N5OS","Free Base","N/A","COC1=CC(=C(NC2=NC(=CS2)C3=C(C)N=C4N=CC=C[N]34)C(=C1)Br)Br",4.871,4,1,4]
["S7373","UNC669","b4","L3000-29","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4.",338.24,"1314241-44-5",{"v":11,"d":"11.00"},32.52,"<1","N/A","http://selleckchem.com/products/unc669.html","C15H20BrN3O","free base","N/A","BrC1=CN=CC(=C1)C(=O)N2CCC(CC2)N3CCCC3",1.413,2,0,2]
["S7378","AEBSF HCl","c4","L3000-29","in 10mM DMSO","Serine Protease","Proteases","AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.",239.69,"30827-99-7",{"v":47,"d":"47.00"},196.09,{"v":20,"d":"20.00"},83.44,"http://selleckchem.com/products/aebsf-hcl.html","C8H11ClFNO2S","Hydrochloride","N/A","Cl.NCCC1=CC=C(C=C1)[S](F)(=O)=O",1.261,2,1,3]
["S7379","E-64","d4","L3000-29","in 10mM DMSO","Apoptosis related,Cathepsin B,Cysteine Protease,Parasite","Proteases","E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.",357.41,"66701-25-5",{"v":71,"d":"71.00"},198.65,{"v":11,"d":"11.00"},30.78,"http://selleckchem.com/products/e-64.html","C15H27N5O5","free base","N/A","CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCNC(N)=N",-0.864,4,4,12]
["S7380","Leupeptin Hemisulfate","e4","L3000-29","in 10mM DMSO","Cathepsin B,Cysteine Protease,Serine Protease","Proteases","Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.",475.59,"103476-89-7",{"v":95,"d":"95.00"},199.75,{"v":95,"d":"95.00"},199.75,"http://selleckchem.com/products/leupeptin-hemisulfate.html","C20H38N6O4.1/2H2SO4","sulfate","N/A","CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O",0.977,4,5,15]
["S7381","Pepstatin A","f4","L3000-29","in 10mM DMSO","Autophagy,Cysteine Protease,HIV Protease","Proteases","Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.",685.89,"26305-03-3",{"v":57,"d":"57.00"},{"v":83.1,"d":"83.10"},"<1","N/A","http://selleckchem.com/products/pepstatin-a.html","C34H63N5O9","free base","Pepstatin","CC(C)CC(NC(=O)C(C)NC(=O)CC(O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)C(O)CC(O)=O",2.301,6,7,22]
["S7382","Phosphoramidon Disodium Salt","g4","L3000-29","in 10mM DMSO","RAAS","Endocrinology & Hormones","Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.",589.48,"164204-38-0",{"v":100,"d":"100.00"},169.93,{"v":100,"d":"100.00"},169.93,"http://selleckchem.com/products/phosphoramidon-disodium-salt.html","C23H34N3Na2O10P","Disodium Salt","N/A","CC(C)CC(N[P](O)(=O)OC1OC(C)C(O)C(O)C1O)C(=O)NC(CC2=C[NH]C3=CC=CC=C23)C(O)=O.[Na][Na]",0.472,4,6,11]
["S7383","(-)-p-Bromotetramisole Oxalate","h4","L3000-29","in 10mM DMSO","phosphatase","Others","(-)-p-Bromotetramisole Oxalate (L-p-Bromotetramisole Oxalate) is a potent and non-specific alkaline phosphatase inhibitor.",373.22,"62284-79-1",{"v":74,"d":"74.00"},198.27,{"v":30,"d":"30.00"},80.38,"http://selleckchem.com/products/--p-Bromotetramisole-Oxalate.html","C13H13BrN2O4S","Oxalate","L-p-Bromotetramisole Oxalate","OC(=O)C(O)=O.BrC1=CC=C(C=C1)C2CN3CCSC3=N2",{"v":2.61,"d":"2.610"},3,0,2]
["S7386","MG-101 (ALLN)","a5","L3000-29","in 10mM DMSO","Cysteine Protease","Proteases","MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.",383.53,"110044-82-1",{"v":76,"d":"76.00"},198.16,"<1","N/A","http://selleckchem.com/products/mg-101-alln.html","C20H37N3O4","Oxalate","Calpain inhibitor-1, Ac-LLnL-CHO","CCCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O",2.348,4,3,13]
["S7391","Z-FA-FMK","b5","L3000-29","in 10mM DMSO","Cysteine Protease","Proteases","Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.",386.42,"197855-65-5",{"v":77,"d":"77.00"},199.27,"<1","N/A","http://selleckchem.com/products/z-fa-fmk.html","C21H23FN2O4","free base","(1S)-Z-FA-FMK","CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2)C(=O)CF",3.034,4,2,10]
["S7392","Loxistatin Acid (E-64C)","c5","L3000-29","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Loxistatin Acid (E-64C, NSC 694279, EP 475), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry.",314.38,"76684-89-4",{"v":62,"d":"62.00"},197.21,{"v":2,"d":"2.00"},6.36,"http://selleckchem.com/products/loxistatin-acid-e-64c.html","C15H26N2O5","free base","NSC 694279, EP 475","CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(O)=O",1.037,4,2,9]
["S7393","Aloxistatin (E64d)","d5","L3000-29","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.",342.43,"88321-09-9",{"v":68,"d":"68.00"},198.58,"<1","N/A","http://selleckchem.com/products/Aloxistatin.html","C17H30N2O5","free base","E-64d","CCOC(=O)C1OC1C(=O)NC(CC(C)C)C(=O)NCCC(C)C",1.611,5,2,11]
["S7396","Calpeptin","e5","L3000-29","in 10mM DMSO","Apoptosis related,Cysteine Protease","Proteases","Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.",362.46,"117591-20-5",{"v":72,"d":"72.00"},198.64,"<1","N/A","http://selleckchem.com/products/calpeptin.html","C20H30N2O4","free base","N/A","CCCCC(NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",{"v":3.8,"d":"3.800"},4,2,12]
["S7397","Sorafenib (BAY 43-9006)","f5","L3000-29","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1","N/A","http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7399","FLI-06","g5","L3000-29","in 10mM DMSO","Notch","Stem Cells & Wnt","FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.",438.52,"313967-18-9",{"v":88,"d":"88.00"},200.67,"<1","N/A","http://selleckchem.com/products/fli-06.html","C25H30N2O5","free base","N/A","CC1=C(C(C2=CC=C(C=C2)[N+]([O-])=O)C3=C(CC(C)(C)CC3=O)N1)C(=O)OC4CCCCC4",{"v":4.32,"d":"4.320"},3,1,5]
["S7409","Anisomycin","h5","L3000-29","in 10mM DMSO","Apoptosis related,Autophagy,JNK","MAPK","Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.",{"v":265.3,"d":"265.30"},"22862-76-6",{"v":41,"d":"41.00"},154.54,"<1","N/A","http://selleckchem.com/products/anisomycin.html","C14H19NO4","free base","Flagecidin, Wuningmeisu C","COC1=CC=C(CC2NCC(O)C2OC(C)=O)C=C1",0.877,3,2,5]
["S7414","Caffeic Acid Phenethyl Ester","a6","L3000-29","in 10mM DMSO","NF-κB","NF-κB","Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.",284.31,"104594-70-9",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/caffeic-acid-phenethyl-ester.html","C17H16O4","free base","CAPE, Phenylethyl Caffeate","OC1=CC=C(/C=C/C(=O)OCCC2=CC=CC=C2)C=C1O",3.573,2,2,6]
["S7417","Puromycin (CL13900) 2HCl","b6","L3000-29","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Selection Antibiotics for Transfected Cell","Microbiology","Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.",544.43,"58-58-2",{"v":100,"d":"100.00"},183.68,{"v":100,"d":"100.00"},183.68,"http://selleckchem.com/products/Puromycin-2HCl.html","C22H29N7O5.2HCl","Dihydrochloride","N/A","Cl.Cl.COC1=CC=C(CC(N)C(=O)NC2C(O)C(OC2CO)[N]3C=NC4=C3N=CN=C4N(C)C)C=C1",0.586,6,4,8]
["S7420","CA-074 methyl ester (CA-074 Me)","c6","L3000-29","in 10mM DMSO","Cathepsin B,Cysteine Protease","Proteases","CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.",397.47,"147859-80-1",{"v":79,"d":"79.00"},198.76,{"v":79,"d":"79.00"},198.76,"http://selleckchem.com/products/ca-074-methyl-ester.html","C19H31N3O6","free base","Cathepsin B Inhibitor IV","CCCNC(=O)C1OC1C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC",0.484,6,2,10]
["S7421","CGP 57380","d6","L3000-29","in 10mM DMSO","Apoptosis related,MNK,Wnt/beta-catenin","MAPK","CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates β-catenin and potentiates radiation-induced apoptosis.",244.23,"522629-08-9",{"v":48,"d":"48.00"},196.54,"<1","N/A","http://selleckchem.com/products/cgp57380.html","C11H9FN6","free base","N/A","NC1=C2C(=NC=N1)[NH]N=C2NC3=CC=C(F)C=C3",1.981,3,3,2]
["S7422","KN-62","e6","L3000-29","in 10mM DMSO","CaMK","Neuronal Signaling","KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.",721.84,"127191-97-3",{"v":100,"d":"100.00"},138.53,"<1","N/A","http://selleckchem.com/products/kn-62.html","C38H35N5O6S2","free base","N/A","CN(C(CC1=CC=C(O[S](=O)(=O)C2=C3C=CN=CC3=CC=C2)C=C1)C(=O)N4CCN(CC4)C5=CC=CC=C5)[S](=O)(=O)C6=CC=CC7=C6C=CN=C7",4.532,6,0,10]
["S7424","PD 151746","f6","L3000-29","in 10mM DMSO","Cysteine Protease","Proteases","PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.",237.25,"179461-52-0",{"v":47,"d":"47.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pd-151746.html","C11H8FNO2S","free base","N/A","OC(=O)C(/S)=C/C1=C[NH]C2=CC=C(F)C=C12",{"v":2.49,"d":"2.490"},1,1,2]
["S7429","MI-2 (MALT1 inhibitor)","g6","L3000-29","in 10mM DMSO","MALT","Immunology & Inflammation","MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.",455.72,"1047953-91-2",{"v":91,"d":"91.00"},199.68,"<1","N/A","http://selleckchem.com/products/mi-2-malt1-inhibitor.html","C19H17Cl3N4O3","free base","N/A","COCCOC1=N[N](C2=CC=C(NC(=O)CCl)C=C2)C(=N1)C3=CC(=C(Cl)C=C3)Cl",4.653,5,1,8]
["S7430","SB-3CT","h6","L3000-29","in 10mM DMSO","MMP","Proteases","SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.",{"v":306.4,"d":"306.40"},"292605-14-2",{"v":61,"d":"61.00"},199.09,"<1","N/A","http://selleckchem.com/products/sb-3ct.html","C15H14O3S2","free base","N/A","O=[S](=O)(CC1CS1)C2=CC=C(OC3=CC=CC=C3)C=C2",3.377,3,0,5]
["S7434","TAPI-1","a7","L3000-29","in 10mM DMSO","Immunology & Inflammation related,MMP","Immunology & Inflammation","TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).",{"v":499.6,"d":"499.60"},"171235-71-5",{"v":99,"d":"99.00"},198.16,{"v":60,"d":"60.00"},{"v":120.1,"d":"120.10"},"http://selleckchem.com/products/tapi-1.html","C26H37N5O5","free base","N/A","CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN",0.954,4,5,13]
["S7435","AR-A014418","b7","L3000-29","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.",308.31,"487021-52-3",{"v":61,"d":"61.00"},197.85,"<1","N/A","http://selleckchem.com/products/A014418.html","C12H12N4O4S","free base","GSK-3β Inhibitor VIII","COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1",1.529,3,2,5]
["S7436","NH125","c7","L3000-29","in 10mM DMSO","CaMK","Neuronal Signaling","NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.",524.56,"278603-08-0",{"v":100,"d":"100.00"},190.64,"<1","N/A","http://selleckchem.com/products/nh125.html","C27H45IN2","iodide","N/A","[I-].CCCCCCCCCCCCCCCC[N+]1=C(C)[N](CC2=CC=CC=C2)C=C1",6.032,0,0,17]
["S7437","Sal003","d7","L3000-29","in 10mM DMSO","eIF,PERK,phosphatase","ER stress & UPR","Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.",463.21,"1164470-53-4",{"v":93,"d":"93.00"},200.77,"<1","N/A","http://selleckchem.com/products/sal003.html","C18H15Cl4N3OS","free base","N/A","ClC1=CC=C(NC(=S)NC(NC(=O)\\C=C\\C2=CC=CC=C2)C(Cl)(Cl)Cl)C=C1",6.298,1,3,8]
["S7438","ME0328","e7","L3000-29","in 10mM DMSO","PARP","DNA Damage/DNA Repair","ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.",321.37,"1445251-22-8",{"v":64,"d":"64.00"},199.15,"<1","N/A","http://selleckchem.com/products/me0328.html","C19H19N3O2","free base","N/A","CC(NC(=O)CCC1=NC2=CC=CC=C2C(=O)N1)C3=CC=CC=C3",2.213,3,2,5]
["S7440","Ribociclib (LEE011)","f7","L3000-29","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.",434.54,"1211441-98-3",{"v":7,"d":"7.00"},16.11,"<1","N/A","http://selleckchem.com/products/lee011.html","C23H30N8O","free base","N/A","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",{"v":2.9,"d":"2.900"},4,2,5]
["S7441","WS3","g7","L3000-29","in 10mM DMSO","IκB/IKK","NF-κB","WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.",569.58,"1421227-52-2",{"v":100,"d":"100.00"},175.57,"<1","N/A","http://selleckchem.com/products/ws3.html","C28H30F3N7O3","free base","N/A","CN1CCN(CC1)CC2=C(C=C(NC(=O)NC3=CC=C(OC4=CC(=NC=N4)NC(=O)C5CC5)C=C3)C=C2)C(F)(F)F",4.234,5,3,9]
["S7442","WS6","h7","L3000-29","in 10mM DMSO","IκB/IKK","NF-κB","WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.",568.59,"1421227-53-3",{"v":100,"d":"100.00"},175.87,"<1","N/A","http://selleckchem.com/products/ws6.html","C29H31F3N6O3","free base","N/A","CN1CCN(CC1)CC2=C(C=C(NC(=O)CC3=CC=C(OC4=CC(=NC=N4)NC(=O)C5CC5)C=C3)C=C2)C(F)(F)F",{"v":4.36,"d":"4.360"},5,2,10]
["S7443","AP-III-a4 (ENOblock)","a8","L3000-29","in 10mM DMSO","Others","Metabolism","AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.",631.18,"1177827-73-4(free base)",{"v":100,"d":"100.00"},158.43,{"v":9,"d":"9.00"},14.26,"http://selleckchem.com/products/ap-3-a4-enoblock.html","C31H44ClFN8O3","free base","N/A","Cl.NCCOCCOCCNC(=O)CC1=CC=C(NC2=NC(=NC(=N2)NCC3=CC=C(F)C=C3)NCC4CCCCC4)C=C1",5.188,6,5,18]
["S7444","Pyridostatin (RR82) Trifluoroacetate Salt","b8","L3000-29","in 10mM DMSO","G-quadruplex","DNA Damage/DNA Repair","Pyridostatin Trifluoroacetate Salt (RR82) is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.",{"v":710.7,"d":"710.70"},"1472611-44-1",{"v":100,"d":"100.00"},167.61,{"v":100,"d":"100.00"},167.61,"http://selleckchem.com/products/pyridostatin-trifluoroacetate-salt.html","C31H32N8O5.C2HF3O2","trifluoroacetat","N/A","NCCOC1=CC(=NC(=C1)C(=O)NC2=NC3=C(C=CC=C3)C(=C2)OCCN)C(=O)NC4=CC(=C5C=CC=CC5=N4)OCCN.OC(=O)C(F)(F)F",0.425,9,5,14]
["S7445","APX-3330","c8","L3000-29","in 10mM DMSO","DNA/RNA Synthesis,NF-κB","DNA Damage/DNA Repair","APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.",378.46,"136164-66-4",{"v":75,"d":"75.00"},198.17,"<1","N/A","http://selleckchem.com/products/e3330.html","C21H30O6","free base","E3330","CCCCCCCCCC(=C/C1=C(C)C(=O)C(=C(OC)C1=O)OC)\\C(O)=O",4.663,5,0,12]
["S7447","ZLN005","d8","L3000-29","in 10mM DMSO","PGC-1α","Metabolism","ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.",250.34,"49671-76-3",{"v":37,"d":"37.00"},{"v":147.8,"d":"147.80"},"<1","N/A","http://selleckchem.com/products/ZLN005.html","C17H18N2","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3[NH]2",{"v":4.67,"d":"4.670"},1,1,2]
["S7449","CRT0044876","e8","L3000-29","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.",206.15,"6960-45-8",{"v":41,"d":"41.00"},198.88,"<1","N/A","http://selleckchem.com/products/crt0044876.html","C9H6N2O4","free base","NSC 69877,7-NO2-ICA","OC(=O)C1=CC2=C([NH]1)C(=CC=C2)[N+]([O-])=O",1.939,1,1,2]
["S7451","FPH1 (BRD-6125)","f8","L3000-29","in 10mM DMSO","Others","Others","FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.",388.82,"708219-39-0",{"v":78,"d":"78.00"},200.61,"<1","N/A","http://selleckchem.com/products/fph1-brd-6125.html","C16H15ClF2N2O3S","free base","N/A","CC1=CC=C(Cl)C=C1N(CC(=O)NC2=C(F)C=CC=C2F)[S](C)(=O)=O",3.145,3,1,5]
["S7452","FPH2 (BRD-9424)","g8","L3000-29","in 10mM DMSO","Others","Stem Cells & Wnt","FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.",353.83,"957485-64-2",{"v":70,"d":"70.00"},197.84,"<1","N/A","http://selleckchem.com/products/fph2-brd-9424.html","C14H16ClN5O2S","free base","N/A","CC[N]1C=C(NC(=S)NC2=CC(=CC=C2OC)Cl)C(=N1)C(N)=O",3.444,3,3,7]
["S7458","VER-49009","h8","L3000-29","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-49009 (CCT0129397) is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.",387.82,"940289-57-6",{"v":77,"d":"77.00"},198.55,"<1","N/A","http://selleckchem.com/products/ver-49009.html","C19H18ClN3O4","free base","CCT0129397","CCNC(=O)C1=C(C2=CC=C(OC)C=C2)C(=N[NH]1)C3=CC(=C(O)C=C3O)Cl",3.751,3,4,5]
["S7459","VER-50589","a9","L3000-29","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β.",{"v":388.8,"d":"388.80"},"747413-08-7",{"v":77,"d":"77.00"},198.05,"<1","N/A","http://selleckchem.com/products/ver-50589.html","C19H17ClN2O5","free base","N/A","CCNC(=O)C1=NOC(=C1C2=CC=C(OC)C=C2)C3=CC(=C(O)C=C3O)Cl",3.761,4,3,5]
["S7460","BTB06584","b9","L3000-29","in 10mM DMSO","ATPase","Transmembrane Transporters","BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.",417.82,"219793-45-0",{"v":84,"d":"84.00"},201.04,"<1","N/A","http://selleckchem.com/products/btb06584.html","C19H12ClNO6S","free base","N/A","[O-][N+](=O)C1=CC=C(C=C1OC(=O)C2=CC=C(Cl)C=C2)[S](=O)(=O)C3=CC=CC=C3",4.923,4,0,6]
["S7461","LDC000067","c9","L3000-29","in 10mM DMSO","CDK","Cell Cycle","LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.",370.43,"1073485-20-7",{"v":74,"d":"74.00"},199.77,"<1","N/A","http://selleckchem.com/products/ldc000067.html","C18H18N4O3S","free base","LDC067","COC1=CC=CC=C1C2=NC=NC(=C2)NC3=CC(=CC=C3)C[S](N)(=O)=O",2.783,5,2,6]
["S7462","PI-1840","d9","L3000-29","in 10mM DMSO","Proteasome","Proteases","PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).",394.47,"1401223-22-0",{"v":78,"d":"78.00"},197.73,"<1","N/A","http://selleckchem.com/products/pi-1840.html","C22H26N4O3","free base","N/A","CCCC1=CC=C(OCC(=O)N(CC2=NC(=NO2)C3=CC=CN=C3)C(C)C)C=C1",{"v":3.22,"d":"3.220"},6,0,9]
["S7465","FTI 277 HCl","e9","L3000-29","in 10mM DMSO","Anti-infection,Apoptosis related,FTase,Transferase","Metabolism","FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.",484.07,"180977-34-8",{"v":96,"d":"96.00"},198.32,{"v":17,"d":"17.00"},35.12,"http://selleckchem.com/products/fti-277-hcl.html","C22H30ClN3O3S2","hydrochloride salt","N/A","Cl.COC(=O)C(CCSC)NC(=O)C1=C(C=C(NCC(N)CS)C=C1)C2=CC=CC=C2",2.897,3,3,12]
["S7466","GGTI 298 TFA salt","f9","L3000-29","in 10mM DMSO","Transferase","Metabolism","GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.",593.66,"1217457-86-7",{"v":100,"d":"100.00"},168.45,"<1","N/A","http://selleckchem.com/products/ggti-298.html","C27H33N3O3S.C2HF3O2","trifluoroacetat","N/A","COC(=O)C(CC(C)C)NC(=O)C1=CC=C(NCC(N)CS)C=C1C2=C3C=CC=CC3=CC=C2.OC(=O)C(F)(F)F",2.733,4,3,12]
["S7467","LB42708","g9","L3000-29","in 10mM DMSO","FTase,Transferase","Metabolism","LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.",555.46,"226929-39-1",{"v":100,"d":"100.00"},180.03,"<1","N/A","http://selleckchem.com/products/lb42708.html","C30H27BrN4O2","free base","N/A","BrC1=CC=C(C[N]2C=NC=C2C[N]3C=C(C(=O)N4CCOCC4)C(=C3)C5=C6C=CC=CC6=CC=C5)C=C1",4.744,3,0,6]
["S7470","Triapine","h9","L3000-29","in 10mM DMSO","DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.",195.24,"200933-27-3",{"v":20,"d":"20.00"},102.44,"<1","N/A","http://selleckchem.com/products/triapine.html","C7H9N5S","free base","3-AP","NC(=S)N/N=C/C1=NC=CC=C1N",0.331,2,3,3]
["S7473","Nexturastat A","a10","L3000-29","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.",{"v":341.4,"d":"341.40"},"1403783-31-2",{"v":68,"d":"68.00"},199.18,"<1","N/A","http://selleckchem.com/products/nexturastat-a.html","C19H23N3O3","free base","N/A","CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2",3.079,2,2,7]
["S7476","MG149","b10","L3000-29","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.",340.46,"1243583-85-8",{"v":68,"d":"68.00"},199.73,"<1","N/A","http://selleckchem.com/products/mg149.html","C22H28O3","free base","Tip60 HAT inhibitor","CCCCCCCC1=CC=C(CCC2=C(C(O)=O)C(=CC=C2)O)C=C1",6.872,1,1,10]
["S7482","EHT 1864 2HCl","c10","L3000-29","in 10mM DMSO","Rho","Cell Cycle","EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.",581.47,"754240-09-0",{"v":100,"d":"100.00"},171.98,{"v":100,"d":"100.00"},171.98,"http://selleckchem.com/products/eht-1864.html","C25H29Cl2F3N2O4S","dihydrochloride","N/A","Cl.Cl.FC(F)(F)C1=CC2=C(C=C1)C(=CC=N2)SCCCCCOC3=COC(=CC3=O)CN4CCOCC4",4.663,5,0,11]
["S7483","DMOG","d10","L3000-29","in 10mM DMSO","Autophagy,HIF,Hydroxylase","Metabolism","DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.",175.14,"89464-63-1",{"v":35,"d":"35.00"},199.84,{"v":35,"d":"35.00"},199.84,"http://selleckchem.com/products/dmog.html","C6H9NO5","free base","Dimethyloxalylglycine","COC(=O)CNC(=O)C(=O)OC",-0.918,5,1,5]
["S7484","FH535","e10","L3000-29","in 10mM DMSO","PPAR,Wnt/beta-catenin","Stem Cells & Wnt","FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.",{"v":361.2,"d":"361.20"},"108409-83-2",{"v":72,"d":"72.00"},199.34,"<1","N/A","http://selleckchem.com/products/fh535.html","C13H10Cl2N2O4S","free base","N/A","CC1=C(N[S](=O)(=O)C2=C(Cl)C=CC(=C2)Cl)C=CC(=C1)[N+]([O-])=O",4.027,2,1,4]
["S7488","MPI-0479605","f10","L3000-29","in 10mM DMSO","MPS1","Cell Cycle","MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.",407.51,"1246529-32-7",{"v":62,"d":"62.00"},152.14,"<1","N/A","http://selleckchem.com/products/mpi-0479605.html","C22H29N7O","free base","N/A","CC1=CC(=CC=C1NC2=NC3=C(N=C[NH]3)C(=N2)NC4CCCCC4)N5CCOCC5",4.379,4,3,5]
["S7489","YH239-EE","g10","L3000-29","in 10mM DMSO","MDM2/MDMX","Apoptosis","YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.",504.41,"1364488-67-4",{"v":100,"d":"100.00"},198.25,"<1","N/A","http://selleckchem.com/products/yh239-ee.html","C25H27Cl2N3O4","free base","N/A","CCOC(=O)C1=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(=O)NC(C)(C)C)C3=C([NH]1)C=C(Cl)C=C3",4.912,4,2,9]
["S7490","WIKI4","h10","L3000-29","in 10mM DMSO","PARP,Wnt/beta-catenin","DNA Damage/DNA Repair","WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.",521.59,"838818-26-1",{"v":7,"d":"7.00"},13.42,"<1","N/A","http://selleckchem.com/products/wiki4.html","C29H23N5O3S","free base","N/A","COC1=CC=C(C=C1)[N]2C(=NN=C2C3=CC=NC=C3)SCCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O",4.469,6,0,8]
["S7492","Uprosertib (GSK2141795)","a11","L3000-29","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Uprosertib (GSK2141795, GSK795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.",429.25,"1047634-65-0",{"v":85,"d":"85.00"},198.02,"<1","N/A","http://selleckchem.com/products/gsk2141795.html","C18H16Cl2F2N4O2","free base","GSK795","C[N]1N=CC(=C1C2=C(Cl)OC(=C2)C(=O)NC(CN)CC3=CC(=C(F)C=C3)F)Cl",3.531,3,2,6]
["S7493","INH1","b11","L3000-29","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","INH1 (IBT 13131) is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.",{"v":308.4,"d":"308.40"},"313553-47-8",{"v":61,"d":"61.00"},{"v":197.8,"d":"197.80"},"<1","N/A","http://selleckchem.com/products/inh1.html","C18H16N2OS","free base","IBT 13131","CC1=CC(=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C",4.531,2,1,3]
["S7494","INH6","c11","L3000-29","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.",322.42,"1001753-24-7",{"v":64,"d":"64.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/inh6.html","C19H18N2OS","free base","N/A","CC1=CC(=C(C(=C1)C)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C",5.017,2,1,3]
["S7495","TAI-1","d11","L3000-29","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.",431.51,"1334921-03-7",{"v":86,"d":"86.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/tai-1.html","C24H21N3O3S","free base","N/A","COC1=CC=C(OC2=CC(=C(C(=C2)C)C3=CSC(=N3)NC(=O)C4=CC=NC=C4)C)C=C1",4.924,5,1,6]
["S7497","CK-636","e11","L3000-29","in 10mM DMSO","Actin,Microtubule Associated","Cytoskeletal Signaling","CK-636 (CK-0944636) is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.",284.38,"442632-72-6",{"v":57,"d":"57.00"},200.44,"<1","N/A","http://selleckchem.com/products/ck-636.html","C16H16N2OS","free base","CK-0944636","CC1=C(CCNC(=O)C2=CC=CS2)C3=CC=CC=C3[NH]1",3.335,1,2,4]
["S7498","DDR1-IN-1","f11","L3000-29","in 10mM DMSO","DDR","Protein Tyrosine Kinase","DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.",552.59,"1449685-96-4",{"v":100,"d":"100.00"},180.97,"<1","N/A","http://selleckchem.com/products/ddr1-in-1.html","C30H31F3N4O3","free base","N/A","CCN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CC(=C(C)C=C3)OC4=CC=C5NC(=O)CC5=C4",4.972,3,2,8]
["S7499","ESI-09","g11","L3000-29","in 10mM DMSO","cAMP","GPCR & G Protein","ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.",330.77,"263707-16-0",{"v":66,"d":"66.00"},199.53,"<1","N/A","http://selleckchem.com/products/esi-09.html","C16H15ClN4O2","free base","N/A","CC(C)(C)C1=CC(=NO1)C(=O)/C(=N/NC2=CC=CC(=C2)Cl)C#N",4.569,4,1,5]
["S7500","HJC0350","h11","L3000-29","in 10mM DMSO","cAMP","GPCR & G Protein","HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.",277.38,"885434-70-8",{"v":52,"d":"52.00"},187.47,"<1","N/A","http://selleckchem.com/products/hjc0350.html","C15H19NO2S","free base","N/A","CC1=C[N](C(=C1)C)[S](=O)(=O)C2=C(C)C=C(C)C=C2C",4.371,2,0,2]
["S7501","HO-3867","a2","L3000-30","in 10mM DMSO","Apoptosis related,STAT","JAK/STAT","HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.",464.55,"1172133-28-6",{"v":13,"d":"13.00"},27.98,"<1","N/A","http://selleckchem.com/products/ho-3867.html","C28H30F2N2O2","free base","N/A","CC1(C)C=C(CN2C\\C(=C/C3=CC=C(F)C=C3)C(=O)C(/C2)=C/C4=CC=C(F)C=C4)C(C)(C)N1O",5.209,1,0,4]
["S7505","(S)-crizotinib","b2","L3000-30","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.",450.34,"1374356-45-2",{"v":42,"d":"42.00"},93.26,"<1","N/A","http://selleckchem.com/products/s-crizotinib.html","C21H22Cl2FN5O","free base","N/A","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S7508","JNK Inhibitor IX","c2","L3000-30","in 10mM DMSO","JNK","MAPK","JNK inhibitor IX (TCS JNK 5a) is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.",332.42,"312917-14-9",{"v":20,"d":"20.00"},60.16,"<1","N/A","http://selleckchem.com/products/jnk-inhibitor-ix.html","C20H16N2OS","free base","TCS JNK 5a","O=C(NC1=C(C#N)C2=C(CCCC2)S1)C3=CC=CC4=C3C=CC=C4",4.571,1,1,2]
["S7509","ML167","d2","L3000-30","in 10mM DMSO","CDK","Cell Cycle","ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.",335.36,"1285702-20-6",{"v":67,"d":"67.00"},199.79,"<1","N/A","http://selleckchem.com/products/ml167.html","C19H17N3O3","free base","CID 44968231","CC1=CC=C(CNC2=NC=NC3=CC=C(C=C23)C4=CC=C(CO)O4)O1",3.033,4,2,5]
["S7511","LY2857785","e2","L3000-30","in 10mM DMSO","CDK","Cell Cycle","LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9(IC50=0.011 μM) and also inhibits other transcription kinases CDK8(IC50=0.016 μM) and CDK7 (IC50=0.246 μM).",{"v":448.6,"d":"448.60"},"1619903-54-6",{"v":23,"d":"23.00"},51.27,"<1","N/A","http://selleckchem.com/products/ly2857785.html","C26H36N6O","free base","N/A","CC(C)C1=C2C=C(C=CC2=N[N]1C)C3=CC=NC(=N3)NC4CCC(CC4)NC5CCOCC5",4.194,4,2,6]
["S7515","VGX-1027","f2","L3000-30","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.",205.21,"6501-72-0",{"v":41,"d":"41.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/vgx-1027.html","C11H11NO3","free base","GIT 27","OC(=O)CC1CC(=NO1)C2=CC=CC=C2",1.368,3,0,3]
["S7516","Y-320","g2","L3000-30","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.",505.01,"288250-47-5",{"v":11,"d":"11.00"},21.78,"<1","N/A","http://selleckchem.com/products/y-320.html","C27H29ClN6O2","free base","N/A","CC1=C(C=N[N]1C2=CC=C(Cl)C=C2)C(=O)NC3=CC=C(N4CCC(CC4)N5CCOCC5)C(=C3)C#N",{"v":3.49,"d":"3.490"},3,1,5]
["S7517","AZD7545","h2","L3000-30","in 10mM DMSO","PDHK","Metabolism","AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.",478.87,"252017-04-2",{"v":95,"d":"95.00"},198.38,"<1","N/A","http://selleckchem.com/products/azd7545.html","C19H18ClF3N2O5S","free base","N/A","CN(C)C(=O)C1=CC=C(C=C1)[S](=O)(=O)C2=CC(=C(NC(=O)C(C)(O)C(F)(F)F)C=C2)Cl",2.913,4,1,6]
["S7519","GNF-5837","a3","L3000-30","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","GNF-5837 is a selective, and orally bioavailable pan-TRK inhibitor for TrkA, and TrkB with IC50 of 8 nM, and 12 nM, respectively.",535.49,"1033769-28-6",{"v":100,"d":"100.00"},186.74,"<1","N/A","http://selleckchem.com/products/gnf-5837.html","C28H21F4N5O2","free base","N/A","CC1=CC=C(NC(=O)NC2=CC(=CC=C2F)C(F)(F)F)C=C1NC3=CC=C\\4C(=C3)NC(=O)C4=C\\C5=CC=C[NH]5",5.993,2,5,6]
["S7520","Darapladib (SB-480848)","b3","L3000-30","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.",666.77,"356057-34-6",{"v":100,"d":"100.00"},149.98,"<1","N/A","http://selleckchem.com/products/darapladib-sb-480848.html","C36H38F4N4O2S","free base","N/A","CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCC5=CC=C(F)C=C5",7.707,3,0,14]
["S7521","Afuresertib (GSK2110183)","c3","L3000-30","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.",427.32,"1047644-62-1",{"v":85,"d":"85.00"},198.91,"<1","N/A","http://selleckchem.com/products/afuresertib-gsk2110183.html","C18H17Cl2FN4OS","free base","N/A","C[N]1N=CC(=C1C2=C(Cl)SC(=C2)C(=O)NC(CN)CC3=CC=CC(=C3)F)Cl",3.884,2,2,6]
["S7523","Entospletinib (GS-9973)","d3","L3000-30","in 10mM DMSO","Syk","Angiogenesis","Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.",411.46,"1229208-44-9",{"v":26,"d":"26.00"},63.19,"<1","N/A","http://selleckchem.com/products/gs-9973.html","C23H21N7O","free base","N/A","C1CN(CCO1)C2=CC=C(NC3=NC(=C[N]4C=CN=C34)C5=CC=C6C=N[NH]C6=C5)C=C2",2.949,4,2,4]
["S7524","FR 180204","e3","L3000-30","in 10mM DMSO","ERK","MAPK","FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK1, MKK4, IKKα, PKCα, Src, Syc, and PDGFα) at less than 30 μM.",327.34,"865362-74-9",{"v":65,"d":"65.00"},198.57,"<1","N/A","http://selleckchem.com/products/fr180204.html","C18H13N7","free base","N/A","NC1=N[NH]C2=C1C=C(N=N2)C3=C4C=CC=C[N]4N=C3C5=CC=CC=C5",2.969,4,2,2]
["S7525","XMD8-92","f3","L3000-30","in 10mM DMSO","Epigenetic Reader Domain,ERK","MAPK","XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with Kd of 80 nM and 170 nM for ERK5 and BRD4(1), respectively.",474.55,"1234480-50-2",{"v":73,"d":"73.00"},153.83,"<1","N/A","http://selleckchem.com/products/xmd8-92.html","C26H30N6O3","free base","N/A","CCOC1=CC(=CC=C1NC2=NC3=C(C=N2)N(C)C(=O)C4=C(C=CC=C4)N3C)N5CCC(O)CC5",3.505,4,2,5]
["S7526","GNF-5","g3","L3000-30","in 10mM DMSO","Bcr-Abl","Angiogenesis","GNF-5 is a selective and allosteric Bcr-Abl inhibitor with IC50 of 220 nM.",418.37,"778277-15-9",{"v":83,"d":"83.00"},198.39,"<1","N/A","http://selleckchem.com/products/gnf-5.html","C20H17F3N4O3","free base","N/A","OCCNC(=O)C1=CC=CC(=C1)C2=CC(=NC=N2)NC3=CC=C(OC(F)(F)F)C=C3",4.876,4,3,8]
["S7528","GNE-7915","h3","L3000-30","in 10mM DMSO","LRRK2","Autophagy","GNE-7915 is a highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor,  with IC50 and Ki of 9 nM and 1 nM, respectively.",{"v":443.4,"d":"443.40"},"1351761-44-8",{"v":22,"d":"22.00"},49.62,"<1","N/A","http://selleckchem.com/products/gne-7915.html","C19H21F4N5O3","free base","N/A","CCNC1=NC(=NC=C1C(F)(F)F)NC2=CC(=C(C=C2OC)C(=O)N3CCOCC3)F",3.052,5,2,7]
["S7529","ML323","a4","L3000-30","in 10mM DMSO","DUB","Ubiquitin","ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.",384.48,"1572414-83-5",{"v":76,"d":"76.00"},197.67,"<1","N/A","http://selleckchem.com/products/ml323.html","C23H24N6","free base","N/A","CC(C)C1=C(C=CC=C1)C2=NC(=C(C)C=N2)NCC3=CC=C(C=C3)[N]4C=CN=N4",5.042,4,1,6]
["S7530","Vactosertib (TEW-7197)","b4","L3000-30","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Vactosertib  (TEW-7197, EW-7197) is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1.",399.42,"1352608-82-2",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/ew-7197.html","C22H18FN7","free base","EW-7197","CC1=NC(=CC=C1)C2=C(N=C(CNC3=CC=CC=C3F)[NH]2)C4=C[N]5N=CN=C5C=C4",3.621,4,2,5]
["S7531","UMI-77","c4","L3000-30","in 10mM DMSO","Bcl-2","Apoptosis","UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.",468.34,"518303-20-3",{"v":93,"d":"93.00"},198.57,"<1","N/A","http://selleckchem.com/products/umi-77.html","C18H14BrNO5S2","free base","N/A","OC(=O)CSC1=C(O)C2=CC=CC=C2C(=C1)N[S](=O)(=O)C3=CC=C(Br)C=C3",3.755,3,2,6]
["S7536","Lorlatinib (PF-6463922)","d4","L3000-30","in 10mM DMSO","ALK,Apoptosis related,ROS1","Protein Tyrosine Kinase","Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 induces apoptosis. Phase 1.",406.41,"1454846-35-5",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/pf-06463922.html","C21H19FN6O2","free base","N/A","CC1OC2=C(N)N=CC(=C2)C3=C(C#N)[N](C)N=C3CN(C)C(=O)C4=C1C=C(F)C=C4",2.343,4,1,0]
["S7539","PTC-209 HBr","e4","L3000-30","in 10mM DMSO","BMI-1","Cell Cycle","PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).",{"v":576.1,"d":"576.10"},"1217022-63-3",{"v":100,"d":"100.00"},173.58,"<1","N/A","http://selleckchem.com/products/ptc-209-hbr.html","C17H13Br2N5OS.HBr","free base","N/A","Br.COC1=CC(=C(NC2=NC(=CS2)C3=C(C)N=C4N=CC=C[N]34)C(=C1)Br)Br",5.362,4,1,4]
["S7540","SB273005","f4","L3000-30","in 10mM DMSO","Integrin","Cytoskeletal Signaling","SB273005 is a potent integrin inhibitor with Ki  of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.",451.44,"205678-31-5",{"v":90,"d":"90.00"},199.36,"<1","N/A","http://selleckchem.com/products/sb273005.html","C22H24F3N3O4","free base","N/A","CNC1=CC=CC(=N1)CCOC2=CC=C3CC(CC(O)=O)C(=O)N(CC3=C2)CC(F)(F)F",3.364,4,1,9]
["S7541","Decernotinib (VX-509)","g4","L3000-30","in 10mM DMSO","JAK","JAK/STAT","Decernotinib (VX-509) is a potent and selective JAK3 inhibitor with Ki of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3.",392.38,"944842-54-0",{"v":78,"d":"78.00"},198.79,"<1","N/A","http://selleckchem.com/products/decernotinib-vx-509.html","C18H19F3N6O","free base","N/A","CCC(C)(NC1=NC(=NC=C1)C2=C[NH]C3=NC=CC=C23)C(=O)NCC(F)(F)F",2.747,4,3,7]
["S7545","G-749","h4","L3000-30","in 10mM DMSO","FLT3","Angiogenesis","G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.",521.41,"1457983-28-6",{"v":24,"d":"24.00"},46.03,"<1","N/A","http://selleckchem.com/products/g-749.html","C25H25BrN6O2","free base","N/A","CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(OC5=CC=CC=C5)C=C4",3.919,4,3,6]
["S7546","Pritelivir (BAY 57-1293)","a5","L3000-30","in 10mM DMSO","DNA/RNA Synthesis,HSV","DNA Damage/DNA Repair","Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.",402.49,"348086-71-5",{"v":80,"d":"80.00"},198.76,"<1","N/A","http://selleckchem.com/products/bay-57-1293.html","C18H18N4O3S2","free base","AIC316","CN(C(=O)CC1=CC=C(C=C1)C2=NC=CC=C2)C3=NC(=C(S3)[S](N)(=O)=O)C",1.761,5,1,5]
["S7549","THZ1 2HCl","b5","L3000-30","in 10mM DMSO","CDK","Cell Cycle","THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.",638.97,"2095433-94-4",{"v":100,"d":"100.00"},{"v":156.5,"d":"156.50"},"<1","N/A","http://selleckchem.com/products/thz1.html","C31H30Cl3N7O2","dihydrochloride","N/A","Cl.Cl.CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC=C5",6.383,4,4,9]
["S7551","Piperlongumine","c5","L3000-30","in 10mM DMSO","CRM1,ROS","Immunology & Inflammation","Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.",317.34,"20069-09-4",{"v":16,"d":"16.00"},50.42,"<1","N/A","http://selleckchem.com/products/piperlongumine.html","C17H19NO5","free base","PPLGM, Piplartine","COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O",2.135,5,0,5]
["S7552","CFI-400945","d5","L3000-30","in 10mM DMSO","PLK","Cell Cycle","CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM.",534.65,"1338806-73-7",{"v":100,"d":"100.00"},187.04,"<1","N/A","http://selleckchem.com/products/cfi-400945.html","C33H34N4O3","free base","N/A","COC1=CC2=C(NC(=O)C23CC3C4=CC=C5C(=C4)[NH]N=C5\\C=C\\C6=CC=C(CN7CC(C)OC(C)C7)C=C6)C=C1",5.169,4,2,6]
["S7553","GDC-0623","e5","L3000-30","in 10mM DMSO","MEK","MAPK","GDC-0623 (G-868) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.",456.21,"1168091-68-6",{"v":91,"d":"91.00"},199.47,"<1","N/A","http://selleckchem.com/products/gdc-0623.html","C16H14FIN4O3","free base","G-868","OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)[N]3C=NC=C3C=C1",2.284,3,3,6]
["S7555","Domatinostat (4SC-202)","f5","L3000-30","in 10mM DMSO","HDAC","Epigenetics","Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.",447.51,"910462-43-0",{"v":89,"d":"89.00"},198.88,"<1","N/A","http://selleckchem.com/products/4sc-202.html","C23H21N5O3S","free base","N/A","C[N]1C=C(C=N1)C2=CC=C(C=C2)[S](=O)(=O)[N]3C=CC(=C3)\\C=C\\C(=O)NC4=CC=CC=C4N",2.955,4,2,6]
["S7557","CL-387785 (EKI-785)","g5","L3000-30","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","CL-387785 (EKI-785, WAY-EKI 785) is an irreversible, and selective EGFR inhibitor with IC50 of 370 pM.",381.23,"194423-06-8",{"v":63,"d":"63.00"},165.25,"<1","N/A","http://selleckchem.com/products/cl-387785-eki-785.html","C18H13BrN4O","free base","WAY-EKI 785","CC#CC(=O)NC1=CC2=C(NC3=CC=CC(=C3)Br)N=CN=C2C=C1",4.568,3,2,4]
["S7559","Darolutamide (ODM-201)","h5","L3000-30","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3.",398.85,"1297538-32-9",{"v":80,"d":"80.00"},200.58,"<1","N/A","http://selleckchem.com/products/odm-201.html","C19H19ClN6O2","free base","BAY-1841788","CC(O)C1=CC(=N[NH]1)C(=O)NC(C)C[N]2C=CC(=N2)C3=CC(=C(C=C3)C#N)Cl",3.034,3,3,6]
["S7563","AT13148","a6","L3000-30","in 10mM DMSO","Akt,PKA,ROCK,S6 Kinase","PI3K/Akt/mTOR","AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.",313.78,"1056901-62-2",{"v":62,"d":"62.00"},197.59,"<1","N/A","http://selleckchem.com/products/at13148.html","C17H16ClN3O","free base","N/A","NCC(O)(C1=CC=C(Cl)C=C1)C2=CC=C(C=C2)C3=C[NH]N=C3",2.491,1,2,4]
["S7564","SAR125844","b6","L3000-30","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).",550.63,"1116743-46-4",{"v":11,"d":"11.00"},19.98,"<1","N/A","http://www.selleck.cn/products/sar125844.html","C25H23FN8O2S2","free base","N/A","FC1=CC=C(C=C1)C2=N[N]3C(=NN=C3C=C2)SC4=CC=C5N=C(NC(=O)NCCN6CCOCC6)SC5=C4",4.518,6,2,7]
["S7565","WH-4-023","c6","L3000-30","in 10mM DMSO","SIK,Src","Angiogenesis","WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.",568.67,"837422-57-8",{"v":12,"d":"12.00"},{"v":21.1,"d":"21.10"},"<1","N/A","http://selleckchem.com/products/wh-4-023.html","C32H36N6O4","free base","KIN001-112, KIN112, Dual LCK/SRC inhibitor","COC1=CC=C(N(C(=O)OC2=C(C)C=CC=C2C)C3=CC=NC(=N3)NC4=CC=C(C=C4)N5CCN(C)CC5)C(=C1)OC",6.843,6,1,9]
["S7566","IM-12","d6","L3000-30","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.",377.41,"1129669-05-1",{"v":75,"d":"75.00"},198.72,"<1","N/A","http://selleckchem.com/products/im-12.html","C22H20FN3O2","free base","N/A","CN1C(=O)C(=C(C1=O)C2=C(C)[NH]C3=C2C=CC=C3)NCCC4=CC=C(F)C=C4",3.074,2,2,5]
["S7569","LMK-235","e6","L3000-30","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.",294.35,"1418033-25-6",{"v":58,"d":"58.00"},197.04,"<1","N/A","http://selleckchem.com/products/lmk-235.html","C15H22N2O4","free base","N/A","CC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)C",2.204,3,2,8]
["S7570","UNC0379","f6","L3000-30","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases.",413.56,"1620401-82-2",{"v":82,"d":"82.00"},198.28,"<1","N/A","http://selleckchem.com/products/unc0379.html","C23H35N5O2","free base","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCCC3)NCCCCCN4CCCC4",4.545,4,1,10]
["S7572","A-366","g6","L3000-30","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.",329.44,"1527503-11-2",{"v":65,"d":"65.00"},{"v":197.3,"d":"197.30"},"<1","N/A","http://selleckchem.com/products/a-366.html","C19H27N3O2","free base","N/A","COC1=C(OCCCN2CCCC2)C=C3N=C(N)C4(CCC4)C3=C1",2.467,3,1,6]
["S7573","GSK2830371","h6","L3000-30","in 10mM DMSO","phosphatase","Others","GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.",461.02,"1404456-53-6",{"v":92,"d":"92.00"},199.56,"<1","N/A","http://selleckchem.com/products/gsk2830371.html","C23H29ClN4O2S","free base","N/A","CC1=NC=C(Cl)C=C1NCC2=CC=C(S2)C(=O)NC(CC3CCCC3)C(=O)NC4CC4",4.064,3,3,9]
["S7574","GSK-LSD1 2HCl","a7","L3000-30","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).",289.24,"2102933-95-7",{"v":57,"d":"57.00"},197.07,{"v":57,"d":"57.00"},197.07,"http://selleckchem.com/products/gsk-lsd1-2hcl.html","C14H22Cl2N2","dihydrochloride","N/A","Cl.Cl.C1CC(CCN1)NC2CC2C3=CC=CC=C3",1.964,0,2,3]
["S7575","LLY-507","b7","L3000-30","in 10mM DMSO","Histone Methyltransferase,SMYD","Epigenetics","LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.",574.76,"1793053-37-8",{"v":100,"d":"100.00"},173.99,"<1","N/A","http://selleckchem.com/products/lly-507.html","C36H42N6O","free base","N/A","CC1=C[N](CCN2CCN(CC2)C3=CC=CC=C3C4=CC(=CC(=C4)C(=O)NCCCN5CCCC5)C#N)C6=C1C=CC=C6",5.851,1,1,10]
["S7576","UNC2025 HCl","c7","L3000-30","in 10mM DMSO","Axl,FLT3,Mertk,Tyro3","Protein Tyrosine Kinase","UNC2025 HCl is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.",513.12,"2070015-17-5",{"v":25,"d":"25.00"},48.72,{"v":100,"d":"100.00"},194.89,"http://selleckchem.com/products/unc-2025.html","C28H41ClN6O","hydrochloride salt","UNC2025 hydrochloride","Cl.CCCCNC1=NC=C2C(=C[N](C3CCC(O)CC3)C2=N1)C4=CC=C(CN5CCN(C)CC5)C=C4",{"v":4.96,"d":"4.960"},2,2,8]
["S7577","AGK2","d7","L3000-30","in 10mM DMSO","Sirtuin","Cytoskeletal Signaling","AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.",434.27,"304896-28-4",{"v":10,"d":"10.00"},23.03,"<1","N/A","http://selleckchem.com/products/agk2.html","C23H13Cl2N3O2","free base","N/A","ClC1=CC=C(Cl)C(=C1)C2=CC=C(O2)\\C=C(C#N)/C(=O)NC3=C4C=CC=NC4=CC=C3",5.641,3,1,4]
["S7579","Ledipasvir (GS5885)","e7","L3000-30","in 10mM DMSO","COVID-19,HCV Protease","Microbiology","Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.",{"v":889,"d":"889.00"},"1256388-51-8",{"v":100,"d":"100.00"},112.49,"<1","N/A","http://selleckchem.com/products/ledipasvir-gs5885.html","C49H54F2N8O6","free base","N/A","COC(=O)NC(C(C)C)C(=O)N1C2CCC(C2)C1C3=NC4=CC=C(C=C4[NH]3)C5=CC=C6C7=CC=C(C=C7C(F)(F)C6=C5)C8=CN=C([NH]8)C9CCC%10(CC%10)N9C(=O)C(NC(=O)OC)C(C)C",7.304,8,4,12]
["S7581","GSK J1","f7","L3000-30","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM  in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.",389.45,"1373422-53-7",{"v":77,"d":"77.00"},197.71,"<1","N/A","http://selleckchem.com/products/gsk-j1.html","C22H23N5O2","free base","N/A","OC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",3.707,4,1,6]
["S7582","Anacardic Acid","g7","L3000-30","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,\n\nprostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.",348.52,"16611-84-0",{"v":69,"d":"69.00"},197.98,"<1","N/A","http://selleckchem.com/products/anacardic-acid.html","C22H36O3","free base","6-pentadecylsalicylic Acid","CCCCCCCCCCCCCCCC1=CC=CC(=C1C(O)=O)O",{"v":8.09,"d":"8.090"},1,1,15]
["S7584","LRRK2-IN-1","h7","L3000-30","in 10mM DMSO","LRRK2","Autophagy","LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.",570.69,"1234480-84-2",{"v":100,"d":"100.00"},175.23,"<1","N/A","http://selleckchem.com/products/lrrk2-in-1.html","C31H38N8O3","free base","N/A","COC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C)C3=N2)C=CC(=C1)C(=O)N5CCC(CC5)N6CCN(C)CC6",3.043,5,1,5]
["S7587","Epacadostat (INCB024360) analogue","a8","L3000-30","in 10mM DMSO","IDO/TDO","Metabolism","Epacadostat (INCB024360) analogue (INCB14943) is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM.",271.64,"914471-09-3",{"v":54,"d":"54.00"},198.79,"<1","N/A","http://selleckchem.com/products/incb024360.html","C9H7ClFN5O2","free base","INCB14943","NC1=NON=C1C(/NC2=CC=C(F)C(=C2)Cl)=N\\O",1.577,4,2,3]
["S7588","Reversine","b8","L3000-30","in 10mM DMSO","Adenosine Receptor,Aurora Kinase","GPCR & G Protein","Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation.",393.23,"656820-32-5",{"v":5,"d":"5.00"},12.72,"<1","N/A","http://selleckchem.com/products/reversine.html","C21H27N7O","free base","N/A","C1CCC(CC1)NC2=C3N=C[NH]C3=NC(=N2)NC4=CC=C(C=C4)N5CCOCC5",3.893,4,3,5]
["S7591","BRD4770","c8","L3000-30","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.",413.47,"1374601-40-7",{"v":27,"d":"27.00"},{"v":65.3,"d":"65.30"},"<1","N/A","http://selleckchem.com/products/brd4770.html","C25H23N3O3","free base","N/A","COC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4",5.094,4,1,8]
["S7593","Splitomicin","d8","L3000-30","in 10mM DMSO","HDAC","Epigenetics","Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.",198.22,"5690-03-9",{"v":39,"d":"39.00"},196.75,"<1","N/A","http://selleckchem.com/products/splitomicin.html","C13H10O2","free base","N/A","O=C1CCC2=C3C=CC=CC3=CC=C2O1",2.831,2,0,0]
["S7595","Santacruzamate A (CAY10683)","e8","L3000-30","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.",278.35,"1477949-42-0",{"v":55,"d":"55.00"},197.59,"<1","N/A","http://selleckchem.com/products/santacruzamate-a-cay10683.html","C15H22N2O3","free base","N/A","CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1",1.899,3,2,9]
["S7596","CAY10603","f8","L3000-30","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.",{"v":446.5,"d":"446.50"},"1045792-66-2",{"v":89,"d":"89.00"},199.33,"<1","N/A","http://selleckchem.com/products/cay10603.html","C22H30N4O6","free base","BML-281","CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO",{"v":3.23,"d":"3.230"},6,3,12]
["S7597","BV-6","g8","L3000-30","in 10mM DMSO","IAP","Apoptosis","BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.",1205.57,"1001600-56-1(free base)",{"v":100,"d":"100.00"},82.95,{"v":25,"d":"25.00"},20.74,"http://selleckchem.com/products/bv-6.html","C70H96N10O8.xCF3COOH","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCCCCCNC(=O)C(NC(=O)C5CCCN5C(=O)C(NC(=O)C(C)NC)C6CCCCC6)C(C7=CC=CC=C7)C8=CC=CC=C8",8.158,8,8,29]
["S7605","Filgotinib (GLPG0634)","h8","L3000-30","in 10mM DMSO","JAK","JAK/STAT","Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.",{"v":425.5,"d":"425.50"},"1206161-97-8",{"v":85,"d":"85.00"},199.76,"<1","N/A","http://selleckchem.com/products/filgotinib.html","C21H23N5O3S","free base","N/A","O=C(NC1=N[N]2C(=N1)C=CC=C2C3=CC=C(CN4CC[S](=O)(=O)CC4)C=C3)C5CC5",2.461,5,1,5]
["S7606","RBC8","a9","L3000-30","in 10mM DMSO","Ras","GPCR & G Protein","RBC8 is a selective inhibitor of the GTPases RalA and RalB by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA.",424.45,"361185-42-4",{"v":84,"d":"84.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/rbc8.html","C25H20N4O3","free base","N/A","COC1=CC(=C(OC)C=C1)C2C(=C(N)OC3=C2C(=N[NH]3)C4=CC=C5C=CC=CC5=C4)C#N",4.253,4,2,4]
["S7607","BQU57","b9","L3000-30","in 10mM DMSO","Ras","Cell Cycle","BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.",{"v":334.1,"d":"334.10"},"1637739-82-2",{"v":66,"d":"66.00"},197.55,"<1","N/A","http://selleckchem.com/products/bqu57.html","C16H13F3N4O","free base","N/A","C[N]1N=C(C)C2=C1OC(=C(C#N)C2C3=CC=C(C=C3)C(F)(F)F)N",2.861,2,1,2]
["S7611","EI1","c9","L3000-30","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.",390.48,"1418308-27-6",{"v":42,"d":"42.00"},107.56,"<1","N/A","http://selleckchem.com/products/ei1.html","C23H26N4O2","free base","N/A","CCC(CC)[N]1C=CC2=C(C=C(C=C12)C#N)C(=O)NCC3=C(C)C=C(C)NC3=O",{"v":3.54,"d":"3.540"},2,2,6]
["S7612","PX-478 2HCl","d9","L3000-30","in 10mM DMSO","Apoptosis related,HIF","Angiogenesis","PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.",394.12,"685898-44-6",{"v":78,"d":"78.00"},197.91,{"v":78,"d":"78.00"},197.91,"http://selleckchem.com/products/px-478-2hcl.html","C13H20Cl4N2O3","dihydrochloride","N/A","Cl.Cl.NC(CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O",-0.251,1,1,8]
["S7616","CPI-169","e9","L3000-30","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.",528.66,"1450655-76-1",{"v":100,"d":"100.00"},189.16,"<1","N/A","http://selleckchem.com/products/cpi-169.html","C27H36N4O5S","free base","N/A","CC[S](=O)(=O)N1CCC(CC1)C(C)[N]2C(=C(C(=O)NCC3=C(OC)C=C(C)NC3=O)C4=CC=CC=C24)C",{"v":1.74,"d":"1.740"},5,2,8]
["S7617","Tasquinimod","f9","L3000-30","in 10mM DMSO","HDAC","Angiogenesis","Tasquinimod (ABR-215050) is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.",406.36,"254964-60-8",{"v":81,"d":"81.00"},199.33,"<1","N/A","http://selleckchem.com/products/tasquinimod.html","C20H17F3N2O4","free base","ABR-215050","COC1=C2C(=C(C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C2=CC=C1)O",2.797,3,1,4]
["S7618","MI-2 (Menin-MLL Inhibitor)","g9","L3000-30","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.",375.55,"1271738-62-5",{"v":75,"d":"75.00"},199.71,"<1","N/A","http://selleckchem.com/products/mi-2-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.161,3,0,4]
["S7619","MI-3 (Menin-MLL Inhibitor)","h9","L3000-30","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.",375.55,"1271738-59-0",{"v":19,"d":"19.00"},50.59,"<1","N/A","http://selleckchem.com/products/mi-3-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CC(C)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.168,3,0,3]
["S7620","GSK1324726A (I-BET726)","a10","L3000-30","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK1324726A (I-BET726) is a highly selective inhibitor of BET family proteins with IC50 of 41 nM, 31 nM, and 22 nM for BRD2, BRD3, and BRD4, respectively.",434.91,"1300031-52-0",{"v":86,"d":"86.00"},197.74,"<1","N/A","http://selleckchem.com/products/gsk1324726a-i-bet726.html","C25H23ClN2O3","free base","N/A","CC1CC(NC2=CC=C(Cl)C=C2)C3=C(C=CC(=C3)C4=CC=C(C=C4)C(O)=O)N1C(C)=O",4.648,2,1,4]
["S7623","PI-3065","b10","L3000-30","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.",506.64,"955977-50-1",{"v":50,"d":"50.00"},98.69,"<1","N/A","http://selleckchem.com/products/pi-3065.html","C27H31FN6OS","free base","N/A","FC1=C(C2=NC3=C(SC(=C3)CN4CCN(CC4)CC5CC5)C(=N2)N6CCOCC6)C7=C([NH]C=C7)C=C1",4.778,3,1,6]
["S7624","SD-208","c10","L3000-30","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.",352.75,"627536-09-8",{"v":9,"d":"9.00"},25.51,"<1","N/A","http://selleckchem.com/products/sd-208.html","C17H10ClFN6","free base","N/A","FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4",3.139,5,1,3]
["S7625","Niraparib (MK-4827) tosylate","d10","L3000-30","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.",492.59,"1038915-73-9",{"v":98,"d":"98.00"},198.95,"<1","N/A","http://selleckchem.com/products/mk-4827-niraparib-tosylate.html","C19H20N4O.C7H8O3S","4-?methylbenzen","Niraparib tosylate, MK 4827 tosylate, ZEJULA","CC1=CC=C(C=C1)[S](O)(=O)=O.NC(=O)C2=CC=CC3=C[N](N=C23)C4=CC=C(C=C4)C5CCCNC5",4.267,2,2,4]
["S7627","LDN-214117","e10","L3000-30","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LDN-214117 is a potent and selective BMP type I receptor kinase ALK2 inhibitor with IC50 of 24 nM.",419.52,"1627503-67-6",{"v":83,"d":"83.00"},197.85,"<1","N/A","http://selleckchem.com/products/ldn-214117.html","C25H29N3O3","free base","N/A","COC1=CC(=CC(=C1OC)OC)C2=CC(=CN=C2C)C3=CC=C(C=C3)N4CCNCC4",3.533,4,1,6]
["S7631","TH287","f10","L3000-30","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.",269.13,"1609960-30-6",{"v":53,"d":"53.00"},196.93,"<1","N/A","http://selleckchem.com/products/th287.html","C11H10Cl2N4","free base","N/A","CNC1=CC(=NC(=N1)N)C2=C(Cl)C(=CC=C2)Cl",3.449,2,2,2]
["S7632","TH588","g10","L3000-30","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.",295.17,"1609960-31-7",{"v":20,"d":"20.00"},67.76,"<1","N/A","http://selleckchem.com/products/th588.html","C13H12Cl2N4","free base","N/A","NC1=NC(=CC(=N1)NC2CC2)C3=C(Cl)C(=CC=C3)Cl",3.938,2,2,3]
["S7633","Lomitapide Mesylate","h10","L3000-30","in 10mM DMSO","MTP","Transmembrane Transporters","Lomitapide Mesylate(AEGR-733 Mesylate,BMS-2138 Mesylate) is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.",789.83,"202914-84-9",{"v":100,"d":"100.00"},126.61,"<1","N/A","http://selleckchem.com/products/lomitapide-mesylate.html","C40H41F6N3O5S","Mesylate","AEGR-733 Mesylate,BMS-2138 Mesylate","C[S](O)(=O)=O.FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)C5=C(C=CC=C5)C6=C1C=CC=C6",7.377,2,2,12]
["S7634","Cerdulatinib (PRT062070) hydrochloride","a11","L3000-30","in 10mM DMSO","JAK,Syk","JAK/STAT","Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.",{"v":482,"d":"482.00"},"1369761-01-2",{"v":43,"d":"43.00"},89.21,"<1","N/A","http://selleckchem.com/products/cerdulatinib-prt062070-prt2070.html","C20H28ClN7O3S","hydrochloride","PRT2070 hydrochloride","Cl.CC[S](=O)(=O)N1CCN(CC1)C2=CC=C(NC3=NC(=C(C=N3)C(N)=O)NC4CC4)C=C2",1.862,5,3,8]
["S7636","SU9516","b11","L3000-30","in 10mM DMSO","CDK","Cell Cycle","SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.",241.25,"377090-84-1",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/su9516.html","C13H11N3O2","free base","N/A","COC1=CC=C2NC(=O)C(=C\\C3=CN=C[NH]3)/C2=C1",0.893,3,2,2]
["S7637","DTP3","c11","L3000-30","in 10mM DMSO","DNA/RNA Synthesis,JNK,NF-κB","MAPK","DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.",{"v":525.6,"d":"525.60"},"1809784-29-9",{"v":100,"d":"100.00"},190.26,{"v":100,"d":"100.00"},190.26,"http://selleckchem.com/products/dtp3.html","C26H35N7O5","free base","N/A","CC(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC2=CC=CC=C2)C(N)=O",{"v":0,"d":"0.000"},4,7,15]
["S7638","LDC1267","d11","L3000-30","in 10mM DMSO","Axl,Mertk,Tyro3","Protein Tyrosine Kinase","LDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8.",560.55,"1361030-48-9",{"v":100,"d":"100.00"},{"v":178.4,"d":"178.40"},"<1","N/A","http://selleckchem.com/products/ldc1267.html","C30H26F2N4O5","free base","N/A","CCOC1=C[N](N=C1C(=O)NC2=CC=C(OC3=CC=NC4=CC(=C(OC)C=C34)OC)C(=C2)F)C5=CC=C(F)C=C5C",6.213,7,1,9]
["S7639","3PO","e11","L3000-30","in 10mM DMSO","PFKFB","Cell Cycle","3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.",210.23,"18550-98-6",{"v":42,"d":"42.00"},199.78,"<1","N/A","http://selleckchem.com/products/3po.html","C13H10N2O","free base","3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one","O=C(/C=C/C1=CC=CN=C1)C2=CC=NC=C2",{"v":1.4,"d":"1.400"},3,0,3]
["S7641","Remodelin hydrobromide","f11","L3000-30","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.",363.28,"1622921-15-6",{"v":72,"d":"72.00"},198.19,"<1","N/A","http://selleckchem.com/products/remodelin.html","C15H15BrN4S","hydrobromide","Remodelin HBr","Br.N#CC1=CC=C(C=C1)C2=CSC(=N2)NN=C3CCCC3",4.031,2,1,3]
["S7642","D 4476","g11","L3000-30","in 10mM DMSO","Casein Kinase","Metabolism","D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.",398.41,"301836-43-1",{"v":79,"d":"79.00"},198.29,"<1","N/A","http://selleckchem.com/products/d-4476.html","C23H18N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=CC=N3)C4=CC5=C(OCCO5)C=C4",3.464,5,2,4]
["S7644","PF-431396","h11","L3000-30","in 10mM DMSO","FAK,Pyk2","Angiogenesis","PF-431396 is a dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively.",{"v":506.5,"d":"506.50"},"717906-29-1",{"v":100,"d":"100.00"},197.43,"<1","N/A","http://selleckchem.com/products/pf-431396.html","C22H21F3N6O3S","free base","N/A","CN(C1=CC=CC=C1CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)[S](C)(=O)=O",3.102,5,3,8]
["S7645","Pilaralisib (XL147)","a2","L3000-31","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.",541.02,"934526-89-3",{"v":100,"d":"100.00"},184.84,"<1","N/A","http://selleckchem.com/products/pilaralisib-xl147.html","C25H25ClN6O4S","free base","N/A","COC1=CC(=C(Cl)C=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=CC(=C4)NC(=O)C(C)(C)N",4.012,6,4,8]
["S7646","Voxtalisib (XL765)","b2","L3000-31","in 10mM DMSO","mTOR,PI3K","Angiogenesis","Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",270.29,"934493-76-2",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/voxtalisib-xl765-sar245409.html","C13H14N6O","free base","SAR245409","CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C3=CC=N[NH]3",0.838,4,2,2]
["S7648","OTS964","c2","L3000-31","in 10mM DMSO","Apoptosis related,Autophagy,CDK,TOPK","MAPK","OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.",428.97,"1338545-07-5",{"v":85,"d":"85.00"},198.15,"<1","N/A","http://selleckchem.com/products/ots964.html","C23H24N2O2S.HCl","dihydrochloride","N/A","Cl.Cl.CC(CN(C)C)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",5.497,1,2,4]
["S7649","MI-773 (SAR405838)","d2","L3000-31","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7650","Peficitinib (ASP015K)","e2","L3000-31","in 10mM DMSO","JAK","JAK/STAT","Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.",326.39,"944118-01-8",{"v":65,"d":"65.00"},199.15,"<1","N/A","http://selleckchem.com/products/peficitinb-asp015k-jnj-54781532.html","C18H22N4O2","free base","JNJ-54781532","NC(=O)C1=C(N[CH]2C3C[CH]4CC2C[C](O)(C4)C3)C5=C([NH]C=C5)N=C1",1.023,2,3,3]
["S7651","SB225002","f2","L3000-31","in 10mM DMSO","CXCR","GPCR & G Protein","SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.",352.14,"182498-32-4",{"v":70,"d":"70.00"},198.78,"<1","N/A","http://selleckchem.com/products/sb225002.html","C13H10BrN3O4","free base","N/A","OC1=CC(=CC=C1NC(=O)NC2=C(Br)C=CC=C2)[N+]([O-])=O",2.923,1,3,3]
["S7652","OTS514 hydrochloride","g2","L3000-31","in 10mM DMSO","Apoptosis related,TOPK","MAPK","OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.",400.92,"2319647-76-0",{"v":80,"d":"80.00"},199.54,{"v":80,"d":"80.00"},199.54,"http://selleckchem.com/products/ots514.html","C21H20N2O2S.HCl","hydrochloride","N/A","Cl.CC(CN)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",4.147,1,3,3]
["S7653","PND-1186 (VS-4718)","h2","L3000-31","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","PND-1186 (VS-4718, SR-2156) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis. Phase 1.",{"v":501.5,"d":"501.50"},"1061353-68-1",{"v":24,"d":"24.00"},47.86,"<1","N/A","http://selleckchem.com/products/pnd-1186-vs-4718.html","C25H26F3N5O3","free base","SR-2156","CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3OC)N4CCOCC4",4.302,4,3,8]
["S7655","Telaglenastat (CB-839)","a3","L3000-31","in 10mM DMSO","Autophagy,Glutaminase","Proteases","Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.",571.57,"1439399-58-2",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/cb-839.html","C26H24F3N7O3S","free base","N/A","FC(F)(F)OC1=CC(=CC=C1)CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2",5.597,8,2,13]
["S7656","CPI-360","b3","L3000-31","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.",437.53,"1802175-06-9",{"v":20,"d":"20.00"},45.71,"<1","N/A","http://selleckchem.com/products/cpi-360.html","C25H31N3O4","free base","N/A","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCOCC3)C4=C2C=CC=C4)C(=O)NC(=C1)C",2.071,4,2,6]
["S7658","Kartogenin","c3","L3000-31","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.",317.34,"4727-31-5",{"v":63,"d":"63.00"},198.53,"<1","N/A","http://selleckchem.com/products/kartogenin.html","C20H15NO3","free base","KGN","OC(=O)C1=C(C=CC=C1)C(=O)NC2=CC=C(C=C2)C3=CC=CC=C3",3.762,2,1,4]
["S7660","Obeticholic Acid","d3","L3000-31","in 10mM DMSO","Autophagy,FXR","Metabolism","Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.",420.63,"459789-99-2",{"v":84,"d":"84.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/obeticholic-acid.html","C26H44O4","free base","INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid","CCC1C(O)C2C3CCC(C(C)CCC(O)=O)C3(C)CCC2C4(C)CCC(O)CC14",{"v":4.79,"d":"4.790"},1,2,5]
["S7663","Ruboxistaurin (LY333531) HCl","e3","L3000-31","in 10mM DMSO","PKC","TGF-beta/Smad","Ruboxistaurin (LY333531) HCl is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.",505.01,"169939-93-9",{"v":50,"d":"50.00"},99.01,"<1","N/A","http://selleckchem.com/products/ly333531.html","C28H28N4O3.HCl","hydrochloride","Ruboxistaurin hydrochloride,  LY333531 hydrochloride","Cl.CN(C)CC1CC[N]2C=C(C3=C2C=CC=C3)C4=C(C(=O)NC4=O)C5=C[N](CCO1)C6=C5C=CC=C6",3.861,3,1,2]
["S7664","GSK2578215A","f3","L3000-31","in 10mM DMSO","LRRK2","Autophagy","GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.",399.42,"1285515-21-0",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/gsk2578215a.html","C24H18FN3O2","free base","N/A","FC1=NC=CC(=C1)C2=CC(=C(OCC3=CC=CC=C3)C=C2)C(=O)NC4=CC=CN=C4",3.985,4,1,6]
["S7665","Zoligratinib (Debio-1347)","g3","L3000-31","in 10mM DMSO","FGFR","Angiogenesis","Zoligratinib (Debio-1347, CH5183284, FF284) is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.",356.38,"1265229-25-1",{"v":71,"d":"71.00"},199.23,"<1","N/A","http://selleckchem.com/products/ch5183284-debio-1347.html","C20H16N6O","free base","CH5183284, FF284","CC1=NC2=C([NH]1)C=C(C=C2)[N]3N=CC(=C3N)C(=O)C4=CC5=C([NH]4)C=CC=C5",3.199,3,3,3]
["S7667","SU5402","h3","L3000-31","in 10mM DMSO","FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.",296.32,"215543-92-3",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/su5402.html","C17H16N2O3","free base","N/A","CC1=C[NH]C(=C1CCC(O)=O)C=C2C(=O)NC3=C2C=CC=C3",2.723,2,2,4]
["S7668","Picropodophyllin (PPP)","a4","L3000-31","in 10mM DMSO","Apoptosis related,IGF-1R","Protein Tyrosine Kinase","Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.",414.41,"477-47-4",{"v":82,"d":"82.00"},197.87,"<1","N/A","http://selleckchem.com/products/picropodophyllin-ppp.html","C22H22O8","free base","AXL1717","COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24",2.111,7,1,4]
["S7669","NPS-1034","b4","L3000-31","in 10mM DMSO","Axl,c-Met","Protein Tyrosine Kinase","NPS-1034 is a dual Met (c-Met)/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.",551.54,"1221713-92-3",{"v":100,"d":"100.00"},181.31,"<1","N/A","http://selleckchem.com/products/nps-1034.html","C31H23F2N5O3","free base","N/A","CN1N(C(=O)C(=C1C)C(=O)NC2=CC=C(OC3=CC=NC4=C3C(=C[NH]4)C5=CC=CC=C5)C(=C2)F)C6=CC=C(F)C=C6",4.795,4,2,6]
["S7672","Omaveloxolone (RTA-408)","c4","L3000-31","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.",554.71,"1474034-05-3",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/omaveloxolone-rta-408.html","C33H44F2N2O3","free base","N/A","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C3(C)CCC5C(C)(C)C(=O)C(=CC45C)C#N)NC(=O)C(C)(F)F",5.339,3,1,2]
["S7673","L-685,458","d4","L3000-31","in 10mM DMSO","Secretase","Proteases","L-685,458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.",672.85,"292632-98-5",{"v":100,"d":"100.00"},148.62,"<1","N/A","http://selleckchem.com/products/l-685-458.html","C39H52N4O6","free base","N/A","CC(C)CC(NC(=O)C(CC(O)C(CC1=CC=CC=C1)NC(=O)OC(C)(C)C)CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(N)=O",{"v":5.62,"d":"5.620"},5,5,19]
["S7674","Savolitinib (AZD6094)","e4","L3000-31","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.",345.36,"1313725-88-0",{"v":16,"d":"16.00"},46.33,"<1","N/A","http://selleckchem.com/products/hmpl-504-azd6094-volitinib.html","C17H15N9","free base","HMPL-504, Volitinib","CC([N]1N=NC2=NC=C(N=C12)C3=C[N](C)N=C3)C4=C[N]5C=CN=C5C=C4",1.032,6,0,3]
["S7675","PF-4989216","f4","L3000-31","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.",{"v":380.4,"d":"380.40"},"1276553-09-3",{"v":76,"d":"76.00"},199.79,"<1","N/A","http://selleckchem.com/products/pf-4989216.html","C18H13FN6OS","free base","N/A","FC1=C(C=CC(=C1)C#N)C2=C(SC(=C2C#N)N3CCOCC3)C4=NC=N[NH]4",2.924,3,1,3]
["S7678","Sacubitril/valsartan (LCZ696)","g4","L3000-31","in 10mM DMSO","Angiotensin Receptor,Apoptosis related,Neprilysin","Proteases","Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.",915.98,"936623-90-4",{"v":30,"d":"30.00"},32.75,{"v":100,"d":"100.00"},109.17,"http://selleckchem.com/products/lcz696.html","C24H29N5O3.C24H29NO5.5/2H2O.3Na","Sodium salt hydrate","Sacubitril, Valsartan","[Na+].[Na+].[Na+].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[NH]3)C(C(C)C)C(O)=O.CCOC(=O)C(C)CC(CC4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)CCC(O)=O",8.591,9,2,22]
["S7679","YK-4-279","h4","L3000-31","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).",{"v":366.2,"d":"366.20"},"1037184-44-3",{"v":73,"d":"73.00"},199.34,"<1","N/A","http://selleckchem.com/products/yk-4-279.html","C17H13Cl2NO4","free base","N/A","COC1=CC=C(C=C1)C(=O)CC2(O)C(=O)NC3=C(Cl)C=CC(=C23)Cl",2.946,3,1,4]
["S7680","SP2509","a5","L3000-31","in 10mM DMSO","Apoptosis related,Autophagy,Histone Demethylase,LSD1","Epigenetics","SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of  13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.",{"v":437.9,"d":"437.90"},"1423715-09-6",{"v":38,"d":"38.00"},86.78,"<1","N/A","http://selleckchem.com/products/sp2509.html","C19H20ClN3O5S","free base","HCI-2509","CC(=N\\NC(=O)C1=CC=CC(=C1)[S](=O)(=O)N2CCOCC2)/C3=CC(=CC=C3O)Cl",1.891,5,2,5]
["S7681","OF-1","b5","L3000-31","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.",440.31,"919973-83-4",{"v":76,"d":"76.00"},172.61,"<1","N/A","http://selleckchem.com/products/of-1.html","C17H18BrN3O4S","free base","N/A","COC1=CC2=C(C=C1N[S](=O)(=O)C3=C(C)C=C(Br)C=C3)N(C)C(=O)N2C",{"v":2.81,"d":"2.810"},4,1,4]
["S7683","PIK-III","c5","L3000-31","in 10mM DMSO","Autophagy,LC3,PI3K","Autophagy","PIK-III (VPS34-IN2), which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.",319.36,"1383716-40-2",{"v":63,"d":"63.00"},197.27,"<1","N/A","http://selleckchem.com/products/pik-iii.html","C17H17N7","free base","VPS34-IN2","NC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",{"v":2.2,"d":"2.200"},5,2,5]
["S7684","Salirasib","d5","L3000-31","in 10mM DMSO","Autophagy,PPMTase,Ras","Cell Cycle","Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.",358.54,"162520-00-5","The physical form of the compound is fat, and can be dissolved in any proportion in DMSO","N/A","N/A","N/A","http://selleckchem.com/products/salirasib.html","C22H30O2S","free base","Farnesylthiosalicylic acid, FTS","CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC1=CC=CC=C1C(O)=O",{"v":7.12,"d":"7.120"},1,0,10]
["S7685","SecinH3","e5","L3000-31","in 10mM DMSO","cytohesin","Apoptosis","SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.",{"v":460.5,"d":"460.50"},"853625-60-2",{"v":92,"d":"92.00"},199.78,"<1","N/A","http://selleckchem.com/products/secinh3.html","C24H20N4O4S","free base","N/A","COC1=N[N](C2=CC=C(NC(=O)CSC3=CC=CC=C3)C=C2)C(=N1)C4=CC=C5OCOC5=C4",4.748,6,1,7]
["S7686","ML141","f5","L3000-31","in 10mM DMSO","Apoptosis related,p38 MAPK,Rho","Cell Cycle","ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.",407.49,"71203-35-5",{"v":81,"d":"81.00"},198.78,"<1","N/A","http://selleckchem.com/products/ml141.html","C22H21N3O3S","free base","CID-2950007","COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)[S](N)(=O)=O)C4=CC=CC=C4",{"v":3.87,"d":"3.870"},4,1,5]
["S7689","BG45","g5","L3000-31","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","BG45 is a class I HDAC inhibitor with IC50 of 289 nM, 2.0 µM, 2.2 µM and >20 µM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively.",214.22,"926259-99-6",{"v":42,"d":"42.00"},196.06,"<1","N/A","http://selleckchem.com/products/bg45.html","C11H10N4O","free base","N/A","NC1=CC=CC=C1NC(=O)C2=NC=CN=C2",-0.005,3,2,2]
["S7691","PS-1145","h5","L3000-31","in 10mM DMSO","IκB/IKK","NF-κB","PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.",322.75,"431898-65-6",{"v":64,"d":"64.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://selleckchem.com/products/ps-1145.html","C17H11ClN4O","free base","N/A","ClC1=CC(=C2[NH]C3=C(C=CN=C3)C2=C1)NC(=O)C4=CN=CC=C4",2.471,3,2,2]
["S7693","Ceralasertib (AZD6738)","a6","L3000-31","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2.",412.51,"1352226-88-0",{"v":82,"d":"82.00"},198.78,"<1","N/A","http://selleckchem.com/products/azd6738.html","C20H24N6O2S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=N)=O)C4=C5C=C[NH]C5=NC=C4",2.427,5,1,4]
["S7694","AZD8186","b6","L3000-31","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.",457.47,"1627494-13-6",{"v":91,"d":"91.00"},198.92,"<1","N/A","http://selleckchem.com/products/azd8186.html","C24H25F2N3O4","free base","N/A","CC(NC1=CC(=CC(=C1)F)F)C2=CC(=CC3=C2OC(=CC3=O)N4CCOCC4)C(=O)N(C)C",3.418,4,1,5]
["S7697","LY2409881","c6","L3000-31","in 10mM DMSO","IκB/IKK","NF-κB","LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.",594.43,"946518-60-1",{"v":20,"d":"20.00"},33.65,"<1","N/A","http://selleckchem.com/products/ly2409881.html","C24H32Cl4N6OS","trihydrochloride","N/A","Cl.Cl.Cl.CN1CCN(CCCNC2=NC=C(Cl)C(=N2)C3=CC4=C(S3)C=CC=C4C(=O)NC5CC5)CC1",5.147,3,2,8]
["S7704","LY2584702 Tosylate","d6","L3000-31","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.",617.62,"1082949-68-5",{"v":7,"d":"7.00"},11.33,"<1","N/A","http://selleckchem.com/products/ly2584702-tosylate.html","C28H27F4N7O3S","free base","N/A","C[N]1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=N[NH]4)C5=CC(=C(F)C=C5)C(F)(F)F.CC6=CC=C(C=C6)[S](O)(=O)=O",5.829,4,1,5]
["S7707","Verdinexor (KPT-335)","e6","L3000-31","in 10mM DMSO","CRM1","Transmembrane Transporters","Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.",442.32,"1392136-43-4",{"v":88,"d":"88.00"},198.95,"<1","N/A","http://selleckchem.com/products/verdinexor-kpt-335.html","C18H12F6N6O","free base","ATG-527","FC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)C2=N[N](\\C=C/C(=O)NNC3=CC=CC=N3)C=N2",3.496,4,2,7]
["S7709","VX-11e","f6","L3000-31","in 10mM DMSO","ERK","MAPK","VX-11e (VTX-11e, Vertex-11e) is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.",500.35,"896720-20-0",{"v":100,"d":"100.00"},199.86,"<1","N/A","http://selleckchem.com/products/vx-11e.html","C24H20Cl2FN5O2","free base","VTX-11e, Vertex-11e","CC1=CN=C(NC2=C(Cl)C=C(F)C=C2)N=C1C3=C[NH]C(=C3)C(=O)NC(CO)C4=CC=CC(=C4)Cl",5.755,3,4,7]
["S7711","CH-223191","g6","L3000-31","in 10mM DMSO","AhR","Metabolism","CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.",333.39,"301326-22-7",{"v":66,"d":"66.00"},197.97,"<1","N/A","http://selleckchem.com/products/ch-223191.html","C19H19N5O","free base","N/A","C[N]1N=CC=C1C(=O)NC2=CC=C(C=C2C)N=NC3=C(C)C=CC=C3",4.897,4,1,4]
["S7714","FIIN-2","h6","L3000-31","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","FIIN-2 is an irreversible, pan-FGFR inhibitor with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM for FGFR1/2/3/4, respectively.",634.73,"1633044-56-0",{"v":69,"d":"69.00"},108.71,"<1","N/A","http://selleckchem.com/products/fiin-2.html","C35H38N8O4","free base","N/A","COC1=CC(=CC(=C1)OC)N2CC3=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N=C3N(CC6=CC=C(NC(=O)C=C)C=C6)C2=O",5.007,6,2,10]
["S7718","BMH-21","a7","L3000-31","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.",360.41,"896705-16-1",{"v":5,"d":"5.00"},13.87,"<1","N/A","http://selleckchem.com/products/bmh-21.html","C21H20N4O2","free base","N/A","CN(C)CCNC(=O)C1=CC=CN2C(=O)C3=C(C=C4C=CC=CC4=C3)N=C12",1.552,3,1,4]
["S7719","CCG-1423","b7","L3000-31","in 10mM DMSO","Rho","Cell Cycle","CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.",454.75,"285986-88-1",{"v":90,"d":"90.00"},197.91,"<1","N/A","http://selleckchem.com/products/ccg-1423.html","C18H13ClF6N2O3","free base","N/A","CC(ONC(=O)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C(=O)NC2=CC=C(Cl)C=C2",4.553,3,2,7]
["S7720","SBE 13 HCl","c7","L3000-31","in 10mM DMSO","PLK","Cell Cycle","SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.",{"v":479.4,"d":"479.40"},"1052532-15-6",{"v":95,"d":"95.00"},198.16,"<1","N/A","http://selleckchem.com/products/sbe-13-hcl.html","C24H28Cl2N2O4","hydrochloride","N/A","Cl.COC1=CC=C(CCNCC2=CC=C(OCC3=CN=C(Cl)C=C3)C(=C2)OC)C=C1OC",4.895,5,1,11]
["S7721","Monomethyl auristatin E (MMAE)","d7","L3000-31","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .",717.98,"474645-27-7",{"v":100,"d":"100.00"},139.28,"<1","N/A","http://selleckchem.com/products/monomethyl-auristatin-e-mmae.html","C39H67N5O7","free base","SGD-1010","CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C)C(O)C2=CC=CC=C2)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C",{"v":3.46,"d":"3.460"},6,4,20]
["S7722","Bikinin","e7","L3000-31","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.",273.08,"188011-69-0",{"v":54,"d":"54.00"},197.74,"<1","N/A","http://selleckchem.com/products/bikinin.html","C9H9BrN2O3","free base","N/A","OC(=O)CCC(=O)NC1=NC=C(Br)C=C1",0.932,3,1,4]
["S7723","PRIMA-1","f7","L3000-31","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7724","Eprenetapopt (APR-246)","g7","L3000-31","in 10mM DMSO","Apoptosis related,Autophagy,p53","Apoptosis","Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.",199.25,"5291-32-7",{"v":40,"d":"40.00"},200.75,"N/A","N/A","http://selleckchem.com/products/apr-246-prima-1met.html","C10H17NO3","free base","PRIMA-1MET","COCC1(CO)N2CCC(CC2)C1=O",-0.364,2,1,3]
["S7725","BLZ945","h7","L3000-31","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","BLZ945(Sotuletinib) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.",398.48,"953769-46-5",{"v":79,"d":"79.00"},198.25,"<1","N/A","http://selleckchem.com/products/blz945.html","C20H22N4O3S","free base","Sotuletinib","CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(NC4CCCCC4O)S3",3.201,4,3,5]
["S7726","BRD73954","a8","L3000-31","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","BRD73954 is a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.",284.31,"1440209-96-0",{"v":56,"d":"56.00"},196.97,"<1","N/A","http://selleckchem.com/products/brd73954.html","C16H16N2O3","free base","N/A","ONC(=O)C1=CC=CC(=C1)C(=O)NCCC2=CC=CC=C2",1.957,2,2,5]
["S7730","NU1025","b8","L3000-31","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NU1025 (NSC 696807) is a potent PARP inhibitor with IC50 of 400 nM.",176.17,"90417-38-2",{"v":35,"d":"35.00"},198.67,"<1","N/A","http://selleckchem.com/products/nu1025.html","C9H8N2O2","free base","NSC 696807","CC1=NC2=C(C=CC=C2O)C(=O)N1",0.587,2,2,0]
["S7731","AZD3839","c8","L3000-31","in 10mM DMSO","BACE","Neuronal Signaling","AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.",431.41,"1227163-84-9",{"v":86,"d":"86.00"},199.35,"<1","N/A","http://selleckchem.com/products/azd3839.html","C24H16F3N5","free base","N/A","NC1=NC(C2=CC=CC(=C2)C3=CN=CN=C3)(C4=CC(=NC=C4)C(F)F)C5=CC=CC(=C15)F",3.574,4,1,4]
["S7732","ISO-1","d8","L3000-31","in 10mM DMSO","MIF","Immunology & Inflammation","ISO-1 (MIF Antagonist) is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.",235.24,"478336-92-4",{"v":47,"d":"47.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/iso-1.html","C12H13NO4","free base","MIF Antagonist","COC(=O)CC1CC(=NO1)C2=CC=C(O)C=C2",1.352,4,1,4]
["S7734","LFM-A13","e8","L3000-31","in 10mM DMSO","BTK","Angiogenesis","LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM, >100-fold selectivity over other protein kinases including JAK1, JAK2, HCK, EGFR,and IRK.",{"v":360,"d":"360.00"},"244240-24-2",{"v":72,"d":"72.00"},{"v":200,"d":"200.00"},"<1","N/A","http://selleckchem.com/products/lfm-a13.html","C11H8Br2N2O2","free base","N/A","C/C(O)=C(C#N)/C(=O)NC1=C(Br)C=CC(=C1)Br",2.645,1,2,2]
["S7738","PRT-060318 2HCl","f8","L3000-31","in 10mM DMSO","Syk","Angiogenesis","PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.",413.34,"1194961-19-7 (free base)",{"v":75,"d":"75.00"},181.45,{"v":75,"d":"75.00"},181.45,"http://selleckchem.com/products/prt-060318-prt318-3hcl.html","C18H24N6O.2HCl","Dihydrochloride","PRT318","Cl.Cl.CC1=CC(=CC=C1)NC2=C(C=NC(=N2)NC3CCCCC3N)C(N)=O",3.706,3,4,5]
["S7740","SAR-020106","g8","L3000-31","in 10mM DMSO","Chk","Cell Cycle","SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM.",382.85,"1184843-57-9",{"v":20,"d":"20.00"},52.24,"<1","N/A","http://selleckchem.com/products/sar-020106.html","C19H19ClN6O","free base","N/A","CC(CN(C)C)OC1=C(N=CC(=N1)NC2=NC=C3C(=CC=CC3=C2)Cl)C#N",3.925,4,1,6]
["S7741","SB239063","h8","L3000-31","in 10mM DMSO","p38 MAPK","MAPK","SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.",{"v":368.4,"d":"368.40"},"193551-21-2",{"v":60,"d":"60.00"},162.87,"<1","N/A","http://selleckchem.com/products/sb239063.html","C20H21FN4O2","free base","N/A","COC1=NC=CC(=N1)C2=C(N=C[N]2C3CCC(O)CC3)C4=CC=C(F)C=C4",3.661,4,1,4]
["S7742","SCR7","a9","L3000-31","in 10mM DMSO","CRISPR/Cas9,DNA/RNA Synthesis","DNA Damage/DNA Repair","SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).  It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos.",332.38,"14892-97-8",{"v":66,"d":"66.00"},198.57,"<1","N/A","http://selleckchem.com/products/scr7.html","C18H12N4OS","free base","N/A","O=C1NC(=S)NC2=C1N=C(C3=CC=CC=C3)C(=N2)C4=CC=CC=C4",4.496,3,2,2]
["S7743","CCT196969","b9","L3000-31","in 10mM DMSO","Raf,Src","MAPK","CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.",513.52,"1163719-56-9",{"v":100,"d":"100.00"},194.73,"<1","N/A","http://selleckchem.com/products/cct196969.html","C27H24FN7O3","free base","N/A","CC(C)(C)C1=N[N](C(=C1)NC(=O)NC2=CC=C(OC3=C4N=CC(=O)NC4=NC=C3)C=C2F)C5=CC=CC=C5",4.782,6,3,6]
["S7745","ANA-12","c9","L3000-31","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.",407.49,"219766-25-3",{"v":37,"d":"37.00"},{"v":90.8,"d":"90.80"},"<1","N/A","http://selleckchem.com/products/ana-12.html","C22H21N3O3S","free base","N/A","O=C1NCCCCC1NC(=O)C2=CC=CC=C2NC(=O)C3=CC4=C(S3)C=CC=C4",3.088,3,3,4]
["S7747","Ro-3306","d9","L3000-31","in 10mM DMSO","Apoptosis related,Bcl-2,CDK","Cell Cycle","RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.",351.45,"872573-93-8",{"v":13,"d":"13.00"},36.99,"<1","N/A","http://selleckchem.com/products/ro-3306.html","C18H13N3OS2","free base","N/A","O=C1N=C(NCC2=CC=CS2)S\\C1=C/C3=CC=C4N=CC=CC4=C3",3.712,3,1,4]
["S7748","EPZ015666 (GSK3235025)","e9","L3000-31","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.",383.44,"1616391-65-1",{"v":60,"d":"60.00"},156.48,"<1","N/A","http://selleckchem.com/products/epz015666.html","C20H25N5O3","free base","GSK3235025","OC(CNC(=O)C1=CC(=NC=N1)NC2COC2)CN3CCC4=C(C3)C=CC=C4",1.038,4,3,7]
["S7750","KNK437","f9","L3000-31","in 10mM DMSO","HSP (HSP90)","Cell Cycle","KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.",245.23,"218924-25-5",{"v":15,"d":"15.00"},61.17,"<1","N/A","http://selleckchem.com/products/knk437.html","C13H11NO4","free base","N/A","O=CN1CCC(=C/C2=CC3=C(OCO3)C=C2)/C1=O",{"v":1.22,"d":"1.220"},4,0,1]
["S7751","VER155008","g9","L3000-31","in 10mM DMSO","Autophagy,HSP (HSP90)","Cytoskeletal Signaling","VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.",{"v":556.4,"d":"556.40"},"1134156-31-2",{"v":100,"d":"100.00"},179.73,"<1","N/A","http://selleckchem.com/products/ver155008.html","C25H23Cl2N7O4","free base","C07","NC1=C2N=C(NCC3=CC=C(Cl)C(=C3)Cl)[N](C4OC(COCC5=CC=C(C=C5)C#N)C(O)C4O)C2=NC=N1",3.253,5,4,8]
["S7752","Pluripotin (SC1)","h9","L3000-31","in 10mM DMSO","ERK,S6 Kinase","MAPK","Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Pluripotin also inhibits RSK1, RSK2, RSK3 and RSK4 with IC50 of 0.5 µM, 2.5 µM, 3.3 µM and 10.0 µM, respectively.",550.53,"839707-37-8",{"v":100,"d":"100.00"},181.64,"<1","N/A","http://selleckchem.com/products/pluripotin-sc1.html","C27H25F3N8O2","free base","N/A","C[N]1N=C(C)C=C1NC2=NC=C3CN(C(=O)N(C)C3=N2)C4=CC(=CC=C4C)NC(=O)C5=CC=CC(=C5)C(F)(F)F",4.789,5,2,6]
["S7753","BPTES","a10","L3000-31","in 10mM DMSO","Glutaminase","Proteases","BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.",524.68,"314045-39-1",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/bptes.html","C24H24N6O2S3","free base","N/A","O=C(CC1=CC=CC=C1)NC2=NN=C(CCSCCC3=NN=C(NC(=O)CC4=CC=CC=C4)S3)S2",3.432,6,2,12]
["S7754","Gilteritinib (ASP2215)","b10","L3000-31","in 10mM DMSO","Axl,FLT3","Protein Tyrosine Kinase","Gilteritinib (ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).",552.71,"1254053-43-4",{"v":100,"d":"100.00"},180.93,"<1","N/A","http://selleckchem.com/products/gilteritinib-asp2215.html","C29H44N8O3","free base","N/A","CCC1=NC(=C(NC2=CC=C(N3CCC(CC3)N4CCN(C)CC4)C(=C2)OC)N=C1NC5CCOCC5)C(N)=O",2.401,5,3,9]
["S7757","6-Thio-dG","c10","L3000-31","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.",283.31,"789-61-7",{"v":56,"d":"56.00"},197.66,"<1","N/A","http://selleckchem.com/products/6-thio-dg.html","C10H13N5O3S","free base","β-TGdR","NC1=NC(=S)C2=C(N1)[N](C=N2)C3CC(O)C(CO)O3",-0.714,3,4,2]
["S7762","TRx0237 (LMTX) mesylate","d10","L3000-31","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.",477.62,"1236208-20-0",{"v":95,"d":"95.00"},{"v":198.9,"d":"198.90"},{"v":95,"d":"95.00"},{"v":198.9,"d":"198.90"},"http://selleckchem.com/products/trx0237-lmtx-mesylate.html","C16H19N3S.2CH4O3S","Dimesylate","Hydromethylthionine mesylate","C[NH+](C)C1=CC=C2NC3=C(SC2=C1)C=C(C=C3)[NH+](C)C.C[S]([O-])(=O)=O.C[S]([O-])(=O)=O",-4.637,0,1,2]
["S7763","D-Luciferin","e10","L3000-31","in 10mM DMSO","Dyes","Others","D-Luciferin (Firefly luciferin) is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications.",280.32,"2591-17-5",{"v":56,"d":"56.00"},199.77,"<1","N/A","http://selleckchem.com/products/d-luciferin.html","C11H8N2O3S2","free base","Firefly luciferin","OC(=O)C1CSC(=N1)C2=NC3=CC=C(O)C=C3S2",2.188,3,1,2]
["S7765","Dovitinib (TKI258) Lactate monohydrate","f10","L3000-31","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib (TKI258) Lactate monohydrate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.",500.52,"915769-50-5 (monohydrate)",{"v":100,"d":"100.00"},207.25,{"v":66,"d":"66.00"},136.78,"http://selleckchem.com/products/dovitinib-tki258-lactate.html","C24H29FN6O5","Lactate monohydrate","CHIR258","O.CC(O)C(O)=O.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(F)C=CC=C5NC4=O",-1.646,3,4,3]
["S7767","AZ6102","g10","L3000-31","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","AZ6102 is a potent TNKS1/2  inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.",428.53,"1645286-75-4",{"v":85,"d":"85.00"},198.35,"<1","N/A","http://selleckchem.com/products/az6102.html","C25H28N6O","free base","AZ-6102","CC1CN(CC(C)N1)C2=NC=C(C(=C2)C)C3=CC=C(C=C3)C4=NC5=C(C=C[N]5C)C(=O)N4",3.649,3,2,3]
["S7769","BP-1-102","h10","L3000-31","in 10mM DMSO","STAT","JAK/STAT","BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM.",626.59,"1334493-07-0",{"v":100,"d":"100.00"},159.59,"<1","N/A","http://selleckchem.com/products/bp-1-102.html","C29H27F5N2O6S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC(=C(C=C3)C(O)=O)O)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",5.979,4,1,9]
["S7771","STF-083010","a11","L3000-31","in 10mM DMSO","IRE1","ER stress & UPR","STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity.",317.38,"307543-71-1",{"v":63,"d":"63.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/stf-083010.html","C15H11NO3S2","free base","N/A","OC1=CC=C2C=CC=CC2=C1C=N[S](=O)(=O)C3=CC=CS3",3.454,3,1,3]
["S7772","Elacridar (GF120918)","b11","L3000-31","in 10mM DMSO","P-gp","Transmembrane Transporters","Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.",563.64,"143664-11-3",{"v":8,"d":"8.00"},14.19,"<1","N/A","http://selleckchem.com/products/elacridar-gf120918.html","C34H33N3O5","free base","GW120918, GG918, GW0918","COC1=C2NC3=C(C=CC=C3C(=O)NC4=CC=C(CCN5CCC6=C(C5)C=C(OC)C(=C6)OC)C=C4)C(=O)C2=CC=C1",5.742,5,2,8]
["S7774","SU6656","c11","L3000-31","in 10mM DMSO","Src","Angiogenesis","SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.",371.45,"330161-87-0",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://selleckchem.com/products/su6656.html","C19H21N3O3S","free base","N/A","CN(C)[S](=O)(=O)C1=CC=C2NC(=O)C(=C\\C3=CC4=C(CCCC4)[NH]3)/C2=C1",2.616,3,2,3]
["S7775","Emricasan (IDN-6556)","d11","L3000-31","in 10mM DMSO","Antiviral,Caspase","Apoptosis","Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.",{"v":569.5,"d":"569.50"},"254750-02-2",{"v":100,"d":"100.00"},175.59,"<1","N/A","http://selleckchem.com/products/emricasan-idn-6556-pf-03491390.html","C26H27F4N3O7","free base","PF 03491390, PF-03491390","CC(NC(=O)C(=O)NC1=C(C=CC=C1)C(C)(C)C)C(=O)NC(CC(O)=O)C(=O)COC2=C(F)C(=CC(=C2F)F)F",3.017,6,3,12]
["S7776","Akti-1/2","e11","L3000-31","in 10mM DMSO","Akt,Apoptosis related","PI3K/Akt/mTOR","Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.",551.64,"612847-09-3",{"v":22,"d":"22.00"},39.88,"<1","N/A","http://selleckchem.com/products/akti-1-2.html","C34H29N7O","free base","Akt Inhibitor VIII","O=C1NC2=C(C=CC=C2)N1C3CCN(CC3)CC4=CC=C(C=C4)C5=C(N=C6C=C7[NH]C=NC7=CC6=N5)C8=CC=CC=C8",5.466,4,2,5]
["S7777","Coelenterazine","f11","L3000-31","in 10mM DMSO","Dyes","Others","Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.",423.46,"55779-48-1",{"v":84,"d":"84.00"},198.37,"<1","N/A","http://selleckchem.com/products/coelenterazine.html","C26H21N3O3","free base","N/A","OC1=CC=C(CC2=NC3=C(CC4=CC=CC=C4)NC(=CN3C2=O)C5=CC=C(O)C=C5)C=C1",3.404,2,3,5]
["S7781","Sunitinib (SU11248)","g11","L3000-31","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1","N/A","http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7782","Dasatinib Monohydrate","h11","L3000-31","in 10mM DMSO","Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib Monohydrate (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.",506.02,"863127-77-9",{"v":21,"d":"21.00"},{"v":41.5,"d":"41.50"},"<1","N/A","http://selleckchem.com/products/dasatinib-monohydrate.html","C22H28ClN7O3S","Monohydrate","BMS-354825 Monohydrate","O.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.232,4,3,7]
["S7783","Combretastatin A4","a2","L3000-32","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.",316.35,"117048-59-6",{"v":63,"d":"63.00"},199.15,"<1","N/A","http://selleckchem.com/products/combretastatin-a4.html","C18H20O5","free base","N/A","COC1=C(O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",3.508,4,1,6]
["S7786","Erlotinib (OSI-774)","b2","L3000-32","in 10mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.",393.44,"183321-74-6",{"v":78,"d":"78.00"},198.25,"<1","N/A","http://selleckchem.com/products/erlotinib.html","C22H23N3O4","free base","CP358774, NSC 718781, Tarceva","COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.309,6,1,10]
["S7787","Docetaxel Trihydrate","c2","L3000-32","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",861.93,"148408-66-6",{"v":100,"d":"100.00"},116.02,"<1","N/A","http://selleckchem.com/products/docetaxel-trihydrate.html","C43H53NO14.3H2O","Trihydrate","RP56976 (NSC 628503) Trihydrate","O.O.O.CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",1.964,10,4,13]
["S7792","SRT2104 (GSK2245840)","d2","L3000-32","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.",516.64,"1093403-33-8",{"v":16,"d":"16.00"},30.97,"<1","N/A","http://selleckchem.com/products/srt2104-gsk2245840.html","C26H24N6O2S2","free base","N/A","CC1=C(SC(=N1)C2=CC=CN=C2)C(=O)NC3=C(C=CC=C3)C4=C[N]5C(=CSC5=N4)CN6CCOCC6",2.813,5,1,6]
["S7793","Purvalanol A","e2","L3000-32","in 10mM DMSO","Apoptosis related,Autophagy,CDK","Cell Cycle","Purvalanol A is a potent, and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated apoptosis and autophagy.",388.89,"212844-53-6",{"v":60,"d":"60.00"},154.29,"<1","N/A","http://selleckchem.com/products/purvalanol-a.html","C19H25ClN6O","free base","N/A","CC(C)C(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NC3=CC=CC(=C3)Cl",4.462,3,3,7]
["S7795","Iadademstat (ORY-1001) 2HCl","f2","L3000-32","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.",303.27,"1431326-61-2",{"v":5,"d":"5.00"},16.49,{"v":61,"d":"61.00"},201.14,"http://selleckchem.com/products/ory-1001-rg-6016.html","C15H22N2.2HCl","dihydrochloride","RG-6016","Cl.Cl.NC1CCC(CC1)NC2CC2C3=CC=CC=C3",2.721,0,2,3]
["S7796","GSK2879552 2HCl","g2","L3000-32","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.",{"v":437.4,"d":"437.40"},"1902123-72-1",{"v":29,"d":"29.00"},{"v":66.3,"d":"66.30"},{"v":44,"d":"44.00"},100.59,"http://selleckchem.com/products/gsk2879552-2hcl.html","C23H28N2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OC(=O)C1=CC=C(CN2CCC(CC2)CNC3CC3C4=CC=CC=C4)C=C1",1.586,1,1,7]
["S7798","GNE-317","h2","L3000-32","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GNE-317 is a potent, brain-penetrant PI3K inhibitor.",414.48,"1394076-92-6",{"v":47,"d":"47.00"},{"v":113.4,"d":"113.40"},"<1","N/A","http://selleckchem.com/products/gne-317.html","C19H22N6O3S","free base","N/A","COC1(COC1)C2=C(C)C3=C(S2)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",{"v":1.5,"d":"1.500"},7,1,4]
["S7799","Pexmetinib (ARRY-614)","a3","L3000-32","in 10mM DMSO","p38 MAPK,Tie-2","MAPK","Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor  with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.",556.63,"945614-12-0",{"v":100,"d":"100.00"},179.65,"<1","N/A","http://selleckchem.com/products/pexmetinib-arry-614.html","C31H33FN6O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NCC3=C(OC4=CC5=C(C=C4)[N](CCO)N=C5)C=CC(=C3)F)C(C)(C)C",6.271,4,3,9]
["S7804","GSK503","b3","L3000-32","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK503 is a potent and specific EZH2 methyltransferase inhibitor.",526.67,"1346572-63-1",{"v":100,"d":"100.00"},189.87,"<1","N/A","http://selleckchem.com/products/gsk503.html","C31H38N6O2","free base","N/A","CC(C)[N]1C=C(C)C2=C1C=C(C=C2C(=O)NCC3=C(C)C=C(C)NC3=O)C4=CC=C(N=C4)N5CCN(C)CC5",4.126,3,2,6]
["S7807","FRAX486","c3","L3000-32","in 10mM DMSO","PAK","Cytoskeletal Signaling","FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of  14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.",513.39,"1232030-35-1",{"v":22,"d":"22.00"},42.85,"<1","N/A","http://selleckchem.com/products/frax486.html","C25H23Cl2FN6O","free base","N/A","CCN1C(=O)C(=CC2=CN=C(NC3=CC(=C(C=C3)N4CCNCC4)F)N=C12)C5=C(Cl)C=C(Cl)C=C5",5.235,3,2,5]
["S7808","AT7519 HCl","d3","L3000-32","in 10mM DMSO","CDK","Cell Cycle","AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.",418.71,"902135-91-5",{"v":52,"d":"52.00"},124.19,{"v":43,"d":"43.00"},{"v":102.7,"d":"102.70"},"http://selleckchem.com/products/at7519-hcl.html","C16H18Cl3N5O2","Hydrochloride","N/A","Cl.ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",{"v":1.98,"d":"1.980"},3,4,4]
["S7810","Afatinib (BIBW2992) Dimaleate","e3","L3000-32","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.",717.18,"850140-73-7",{"v":100,"d":"100.00"},139.44,"<1","N/A","http://selleckchem.com/products/afatinib-bibw2992-dimaleate.html","C24H25ClFN5O3.2C4H4O4","Dimaleate","N/A","CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",{"v":0.96,"d":"0.960"},9,2,12]
["S7811","MHY1485","f3","L3000-32","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.",387.39,"326914-06-1",{"v":4,"d":"4.00"},10.33,"<1","N/A","http://selleckchem.com/products/mhy1485.html","C17H21N7O4","free base","N/A","[O-][N+](=O)C1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C=C1",2.653,5,1,5]
["S7812","Itacitinib (INCB39110)","g3","L3000-32","in 10mM DMSO","JAK","JAK/STAT","Itacitinib(INCB39110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.",553.51,"1334298-90-6",{"v":100,"d":"100.00"},180.67,"<1","N/A","http://selleckchem.com/products/itacitinib-incb39110.html","C26H23F4N9O","free base","N/A","FC1=C(C=CN=C1C(F)(F)F)C(=O)N2CCC(CC2)N3CC(CC#N)(C3)[N]4C=C(C=N4)C5=C6C=C[NH]C6=NC=N5",2.422,5,1,6]
["S7813","AMG319","h3","L3000-32","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.",{"v":385.4,"d":"385.40"},"1608125-21-8",{"v":77,"d":"77.00"},199.79,"<1","N/A","http://selleckchem.com/products/amg319.html","C21H16FN7","free base","N/A","CC(NC1=C2N=C[NH]C2=NC=N1)C3=C(N=C4C=C(F)C=CC4=C3)C5=CC=CC=N5",3.691,5,2,4]
["S7814","AI-10-49","a4","L3000-32","in 10mM DMSO","Others","Apoptosis","AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.",660.52,"1256094-72-0",{"v":100,"d":"100.00"},{"v":151.4,"d":"151.40"},"<1","N/A","http://selleckchem.com/products/ai-10-49.html","C30H22F6N6O5","Free Base","N/A","FC(F)(F)OC1=CC=C2[NH]C(=NC2=C1)C3=NC=C(OCCOCCOC4=CN=C(C=C4)C5=NC6=C([NH]5)C=CC(=C6)OC(F)(F)F)C=C3",8.991,9,2,14]
["S7815","MI-136","b4","L3000-32","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-136  can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.",470.51,"1628316-74-4",{"v":94,"d":"94.00"},199.78,"<1","N/A","http://selleckchem.com/products/mi-136.html","C23H21F3N6S","free base","N/A","FC(F)(F)CC1=CC2=C(NC3CCN(CC3)CC4=CC=C5[NH]C(=CC5=C4)C#N)N=CN=C2S1",4.886,2,2,6]
["S7816","MI-463","c4","L3000-32","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.",484.54,"1628317-18-9",{"v":96,"d":"96.00"},198.13,"<1","N/A","http://selleckchem.com/products/mi-463.html","C24H23F3N6S","free base","N/A","CC1=C2C=C([NH]C2=CC=C1CN3CCC(CC3)NC4=C5C=C(CC(F)(F)F)SC5=NC=N4)C#N",5.372,2,2,6]
["S7818","Pexidartinib (PLX3397)","d4","L3000-32","in 10mM DMSO","Apoptosis related,c-Kit,CSF-1R,FLT3","Protein Tyrosine Kinase","Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.",417.81,"1029044-16-3",{"v":83,"d":"83.00"},198.65,"<1","N/A","http://selleckchem.com/products/pexidartinib-plx3397.html","C20H15ClF3N5","free base","N/A","FC(F)(F)C1=NC=C(CNC2=NC=C(CC3=C[NH]C4=NC=C(Cl)C=C34)C=C2)C=C1",4.811,3,2,6]
["S7820","EPZ020411 2HCl","e4","L3000-32","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM.",515.52,"2070015-25-5",{"v":100,"d":"100.00"},193.98,{"v":81,"d":"81.00"},157.12,"http://selleckchem.com/products/epz020411.html","C25H40Cl2N4O3","dihydrochloride","N/A","Cl.Cl.CNCCN(C)CC1=C[NH]N=C1C2=CC=C(OC3CC(C3)OCCC4CCOCC4)C=C2",3.322,4,2,12]
["S7824","Nazartinib (EGF816)","f4","L3000-32","in 10mM DMSO","EGFR","Angiogenesis","Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.",495.02,"1508250-71-2",{"v":99,"d":"99.00"},199.99,"<1","N/A","http://selleckchem.com/products/nazartinib-egf816-nvs-816.html","C26H31ClN6O2","free base","NVS-816","CN(C)C/C=C/C(=O)N1CCCCC(C1)[N]2C(=NC3=CC=CC(=C23)Cl)NC(=O)C4=CC(=NC=C4)C",3.705,4,1,6]
["S7827","4-Hydroxytamoxifen (Afimoxifene)","g4","L3000-32","in 10mM DMSO","CRISPR/Cas9,Estrogen/progestogen Receptor","Endocrinology & Hormones","4-Hydroxytamoxifen (Afimoxifene)  is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.",387.51,"68392-35-8",{"v":77,"d":"77.00"},{"v":198.7,"d":"198.70"},"<1","N/A","http://selleckchem.com/products/4-hydroxytamoxifen-4-ht-afimoxifene.html","C26H29NO2","free base","Afimoxifene","CCC(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)C3=CC=C(OCCN(C)C)C=C3",6.077,1,1,8]
["S7828","Licochalcone A","h4","L3000-32","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.",{"v":338.4,"d":"338.40"},"58749-22-7",{"v":67,"d":"67.00"},197.99,"<1","N/A","http://selleckchem.com/products/licochalcone-a.html","C21H22O4","free base","N/A","COC1=C(/C=C/C(=O)C2=CC=C(O)C=C2)C=C(C(=C1)O)C(C)(C)C=C",4.667,2,2,6]
["S7829","CB1954","a5","L3000-32","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.",252.18,"21919-05-1",{"v":50,"d":"50.00"},198.27,"<1","N/A","http://selleckchem.com/products/cb1954.html","C9H8N4O5","free base","Tretazicar, NSC 115829","NC(=O)C1=C(C=C(C(=C1)N2CC2)[N+]([O-])=O)[N+]([O-])=O",0.601,1,1,4]
["S7832","SGC707","b5","L3000-32","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.",298.34,"1687736-54-4",{"v":59,"d":"59.00"},197.76,"<1","N/A","http://selleckchem.com/products/sgc707.html","C16H18N4O2","free base","N/A","O=C(NCC(=O)N1CCCC1)NC2=CC3=CC=NC=C3C=C2",{"v":0.43,"d":"0.430"},3,2,3]
["S7833","OICR-9429","c5","L3000-32","in 10mM DMSO","Histone Methyltransferase,WDR5","Epigenetics","OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.",555.59,"1801787-56-3",{"v":38,"d":"38.00"},{"v":68.4,"d":"68.40"},"<1","N/A","http://selleckchem.com/products/oicr-9429.html","C29H32F3N5O3","free base","N/A","CN1CCN(CC1)C2=CC=C(C=C2NC(=O)C3=CNC(=O)C=C3C(F)(F)F)C4=CC(=CC=C4)CN5CCOCC5",2.722,3,2,7]
["S7834","Cyclo (-RGDfK)","d5","L3000-32","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.",717.69,"500577-51-5",{"v":100,"d":"100.00"},139.34,{"v":84,"d":"84.00"},117.04,"http://selleckchem.com/products/cyclo-rgdfk.html","C29H42F3N9O9","free base","N/A","NCCCCC1NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O.OC(=O)C(F)(F)F",-4.172,7,8,14]
["S7835","I-BRD9","e5","L3000-32","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","I-BRD9 (GSK602) is a potent and selective BRD9 inhibitor with pIC50 of 7.3, while it displayed a pIC50 of 5.3 against BRD4.",497.55,"1714146-59-4",{"v":99,"d":"99.00"},198.97,"<1","N/A","http://selleckchem.com/products/i-brd9-gsk602.html","C22H22F3N3O3S2","free base","GSK602","CCN1C=C(C2=CC(=CC=C2)C(F)(F)F)C3=C(C=C(S3)C(=N)NC4CC[S](=O)(=O)CC4)C1=O",2.779,3,1,6]
["S7839","Endoxifen HCl","f5","L3000-32","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.",409.95,"1032008-74-4",{"v":74,"d":"74.00"},180.51,"<1","N/A","http://selleckchem.com/products/endoxifen-hcl.html","C25H28ClNO2","Hydrochloride","N/A","Cl.CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCNC)C=C3",5.923,1,2,8]
["S7843","BI-847325","g5","L3000-32","in 10mM DMSO","Aurora Kinase,MEK","MAPK","BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.",464.56,"1207293-36-4",{"v":19,"d":"19.00"},{"v":40.9,"d":"40.90"},"<1","N/A","http://selleckchem.com/products/bi-847325.html","C29H28N4O2","free base","N/A","CCNC(=O)C#CC1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4",4.041,2,3,8]
["S7844","Cyclo(RGDyK)","h5","L3000-32","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.",847.72,"250612-42-1",{"v":100,"d":"100.00"},117.96,{"v":100,"d":"100.00"},117.96,"http://selleckchem.com/products/cyclo-rgdyk.html","C31H43F6N9O12","ditrifluoroacetic acid","N/A","NCCCCC1NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O.OC=O.OC(=O)C(F)(F)F.FC(F)F",{"v":-3.67,"d":"-3.670"},8,10,14]
["S7845","SirReal2","a6","L3000-32","in 10mM DMSO","Sirtuin","Epigenetics","SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.",420.55,"709002-46-0",{"v":84,"d":"84.00"},199.74,"<1","N/A","http://selleckchem.com/products/sirreal2.html","C22H20N4OS2","free base","N/A","CC1=NC(=NC(=C1)C)SCC(=O)NC2=NC=C(CC3=CC=CC4=CC=CC=C34)S2",4.065,4,1,6]
["S7847","SGI-7079","b6","L3000-32","in 10mM DMSO","Axl","Protein Tyrosine Kinase","SGI-7079, a novel selective Axl inhibitor with an IC50 of 58 nM in vitro, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.",455.53,"1239875-86-5",{"v":91,"d":"91.00"},199.77,"<1","N/A","http://selleckchem.com/products/sgi-7079.html","C26H26FN7","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC4=C(C(=C[NH]4)C)C(=N3)C5=CC(=CC=C5)CC#N)C=C2F",5.286,2,2,5]
["S7849","BDA-366","c6","L3000-32","in 10mM DMSO","Bcl-2","Apoptosis","BDA-366 is a small-molecule Bcl2-BH4 domain antagonist and binds BH4 with high affinity and selectivity. It directly binds to Bcl2 with high binding affinity (Ki =3.3 ± 0.73 nM).",{"v":423.5,"d":"423.50"},"1909226-00-1",{"v":84,"d":"84.00"},198.35,"<1","N/A","http://selleckchem.com/products/bda-366.html","C24H29N3O4","free base","N/A","CCN(CC)CC(O)CNC1=CC=C(NCC2CO2)C3=C1C(=O)C4=CC=CC=C4C3=O",2.467,3,3,10]
["S7851","AZD3264","d6","L3000-32","in 10mM DMSO","IκB/IKK","NF-κB","AZD3264 is a novel IKK2 inhibitor.",{"v":441.5,"d":"441.50"},"1609281-86-8",{"v":88,"d":"88.00"},199.32,"<1","N/A","http://selleckchem.com/products/azd3264.html","C21H23N5O4S","free base","N/A","CC1=C(C(=NO1)C)C2=CC(=C(C=C2)C3=CC(=C(NC(N)=O)S3)C(N)=O)OC4CCNC4",1.235,5,4,6]
["S7854","Ulixertinib (BVD-523)","e6","L3000-32","in 10mM DMSO","ERK","MAPK","Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.",433.33,"869886-67-9",{"v":86,"d":"86.00"},198.46,"<1","N/A","http://selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html","C21H22Cl2N4O2","free base","VRT752271","CC(C)NC1=NC=C(Cl)C(=C1)C2=C[NH]C(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl",4.266,2,4,7]
["S7855","Brilanestrant (GDC-0810)","f6","L3000-32","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Brilanestrant (GDC-0810, ARN-810） is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.",{"v":446.9,"d":"446.90"},"1365888-06-7",{"v":89,"d":"89.00"},199.15,"<1","N/A","http://selleckchem.com/products/brilanestrant-gdc-0810-arn-810.html","C26H20ClFN2O2","free base","ARN-810","CCC(\\C1=CC=C(F)C=C1Cl)=C(C2=CC=C(\\C=C\\C(O)=O)C=C2)/C3=CC4=C([NH]N=C4)C=C3",6.808,2,1,6]
["S7856","Tenofovir Alafenamide (GS-7340)","g6","L3000-32","in 10mM DMSO","Reverse Transcriptase","Microbiology","Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.",476.47,"379270-37-8",{"v":95,"d":"95.00"},199.38,"<1","N/A","http://selleckchem.com/products/tenofovir-alafenamide-gs-7340.html","C21H29N6O5P","free base","N/A","CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C1N=CN=C2N)OC3=CC=CC=C3",1.526,8,2,12]
["S7857","8-Bromo-cAMP","h6","L3000-32","in 10mM DMSO","PKA","GPCR & G Protein","8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.",430.08,"76939-46-3",{"v":5,"d":"5.00"},11.63,{"v":80,"d":"80.00"},186.01,"http://selleckchem.com/products/8-bromo-camp.html","C10H10BrN5NaO6P","sodium salt","8-Br-Camp,8-Bromo-cAMP Sodium","NC1=NC=NC2=C1N=C(Br)[N]2C3OC4CO[P](=O)(O[Na])OC4C3O",-0.479,7,2,2]
["S7858","Dibutyryl-cAMP (Bucladesine)","a7","L3000-32","in 10mM DMSO","PDE,PKA","GPCR & G Protein","Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.",491.37,"16980-89-5",{"v":98,"d":"98.00"},199.44,{"v":98,"d":"98.00"},199.44,"http://selleckchem.com/products/dibutyryl-camp-bucladesine.html","C18H23N5NaO8P","sodium salt","dbcAMP","CCCC(=O)NC1=NC=NC2=C1N=C[N]2C3OC4CO[P](=O)(O[Na])OC4C3OC(=O)CCC",1.028,10,1,9]
["S7863","SC79","b7","L3000-32","in 10mM DMSO","Akt","PI3K/Akt/mTOR","SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.",364.78,"305834-79-1",{"v":72,"d":"72.00"},197.38,"<1","N/A","http://selleckchem.com/products/sc79.html","C17H17ClN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Cl",2.427,5,1,7]
["S7864","Oltipraz","c7","L3000-32","in 10mM DMSO","Nrf2","Immunology & Inflammation","Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.",226.34,"64224-21-1",{"v":39,"d":"39.00"},172.31,"<1","N/A","http://selleckchem.com/products/oltipraz.html","C8H6N2S3","free base","N/A","CC1=C(SSC1=S)C2=NC=CN=C2",2.225,2,0,1]
["S7867","Oleuropein","d7","L3000-32","in 10mM DMSO","Anti-infection,Apoptosis related,Aromatase,PPAR","Immunology & Inflammation","Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.",540.51,"32619-42-4",{"v":100,"d":"100.00"},185.01,{"v":100,"d":"100.00"},185.01,"http://selleckchem.com/products/oleuropein.html","C25H32O13","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C\\C)C1CC(=O)OCCC3=CC(=C(O)C=C3)O",0.166,7,6,11]
["S7870","LJH685","e7","L3000-32","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.",381.42,"1627710-50-2",{"v":76,"d":"76.00"},199.26,"<1","N/A","http://selleckchem.com/products/ljh685.html","C22H21F2N3O","free base","N/A","CN1CCN(CC1)C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(O)C(=C4)F)F",4.004,1,1,3]
["S7871","LJI308","f7","L3000-32","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.",368.38,"1627709-94-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/lji308.html","C21H18F2N2O2","free base","N/A","OC1=C(F)C=C(C=C1F)C2=C(C=CN=C2)C3=CC=C(C=C3)N4CCOCC4",3.735,2,1,3]
["S7875","NVP-CGM097","g7","L3000-32","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7877","ONO-4059 analogue","h7","L3000-32","in 10mM DMSO","BTK","Angiogenesis","ONO-4059 analogue (ONO-WG-307) is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.",{"v":456.5,"d":"456.50"},"1351635-67-0",{"v":20,"d":"20.00"},43.81,"<1","N/A","http://selleckchem.com/products/ono-4059.html","C25H24N6O3","free base","ONO-WG-307","NC1=C2N(C(=O)N(C3CCCN(C3)C(=O)C=C)C2=NC=N1)C4=CC=C(OC5=CC=CC=C5)C=C4",{"v":3.38,"d":"3.380"},5,1,5]
["S7884","AMI-1","a8","L3000-32","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.",548.45,"20324-87-2",{"v":100,"d":"100.00"},182.33,{"v":10,"d":"10.00"},18.23,"http://selleckchem.com/products/ami-1.html","C21H14N2Na2O9S2","disodium salt","N/A","OC1=C2C=CC(=CC2=CC(=C1)[S](=O)(=O)O[Na])NC(=O)NC3=CC=C4C(=CC(=CC4=C3)[S](=O)(=O)O[Na])O",2.703,3,4,6]
["S7885","SBI-0206965","b8","L3000-32","in 10mM DMSO","Apoptosis related,Autophagy,ULK","Autophagy","SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.",489.32,"1884220-36-3",{"v":97,"d":"97.00"},198.23,"<1","N/A","http://selleckchem.com/products/sbi-0206965.html","C21H21BrN4O5","free base","N/A","CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(OC)C(=C3)OC)OC",4.128,7,2,8]
["S7886","Onatasertib (CC 223)","c8","L3000-32","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.",397.47,"1228013-30-6",{"v":79,"d":"79.00"},198.76,"<1","N/A","http://selleckchem.com/products/cc-223.html","C21H27N5O3","free base","ATG-008","COC1CCC(CC1)N2C(=O)CNC3=NC=C(N=C23)C4=CN=C(C=C4)C(C)(C)O",{"v":1.66,"d":"1.660"},5,1,4]
["S7888","Spautin-1","d8","L3000-32","in 10mM DMSO","Apoptosis related,Autophagy,DUB","Autophagy","Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.",271.26,"1262888-28-7",{"v":54,"d":"54.00"},199.07,"<1","N/A","http://selleckchem.com/products/spautin-1.html","C15H11F2N3","free base","N/A","FC1=CC=C(CNC2=NC=NC3=CC=C(F)C=C23)C=C1",{"v":3.73,"d":"3.730"},2,1,3]
["S7889","Xanthohumol","e8","L3000-32","in 10mM DMSO","Acyltransferase,Apoptosis related,CMV,COX","Metabolism","Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.",{"v":354.4,"d":"354.40"},"6754-58-1",{"v":70,"d":"70.00"},197.52,"<1","N/A","http://selleckchem.com/products/xanthohumol.html","C21H22O5","free base","N/A","COC1=C(C(=C(CC=C(C)C)C(=C1)O)O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.816,2,3,6]
["S7891","CC-115","f8","L3000-32","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.",336.35,"1228013-15-7",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cc-115.html","C16H16N8O","free base","N/A","CCN1C(=O)CNC2=NC=C(N=C12)C3=C(C)N=C(C=C3)C4=N[NH]C=N4",0.664,6,2,3]
["S7892","Avadomide (CC-122)","g8","L3000-32","in 10mM DMSO","E3 Ligase ,Immunology & Inflammation related","Ubiquitin","Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.",286.29,"1015474-32-4",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/cc-122.html","C14H14N4O3","Free Base","N/A","CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N",-0.477,4,2,1]
["S7896","Sodium Tauroursodeoxycholate (TUDC)","h8","L3000-32","in 10mM DMSO","Anti-infection","Microbiology","Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.",521.69,"35807-85-3",{"v":100,"d":"100.00"},191.68,{"v":100,"d":"100.00"},191.68,"http://selleckchem.com/products/sodium-tauroursodeoxycholate-tudc.html","C26H44NNaO6S","sodium salt","N/A","CC(CCC(=O)NCC[S](=O)(=O)O[Na])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",3.088,2,3,8]
["S7898","GSK621","a9","L3000-32","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","GSK621 is a specific and potent AMPK activator.",489.91,"1346607-05-3",{"v":97,"d":"97.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/gsk621.html","C26H20ClN3O5","free base","N/A","COC1=CC(=CC=C1)N2C(=O)NC3=C([N](C(=C3)Cl)C4=CC=C(C=C4)C5=C(O)C(=CC=C5)OC)C2=O",5.217,4,2,5]
["S7900","SW033291","b9","L3000-32","in 10mM DMSO","Dehydrogenase","Metabolism","SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Ki of 1.5 nM and 0.1 nM, respectively.",412.59,"459147-39-8",{"v":83,"d":"83.00"},201.17,"<1","N/A","http://selleckchem.com/products/sw033291.html","C21H20N2OS3","free base","N/A","CCCC[S](=O)C1=C(N)C2=C(C=C(N=C2S1)C3=CC=CS3)C4=CC=CC=C4",5.295,2,1,6]
["S7906","PFI-4","c9","L3000-32","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.",380.44,"900305-37-5",{"v":17,"d":"17.00"},44.69,"<1","N/A","http://selleckchem.com/products/pfi-4.html","C21H24N4O3","free base","N/A","COC1=C(C=CC=C1)C(=O)NC2=C(C=C3N(C)C(=O)N(C)C3=C2)N4CCCC4",2.496,3,1,4]
["S7909","Dp44mT","d9","L3000-32","in 10mM DMSO","Others","Others","Dp44mT is a potent iron chelator, which shows selective antitumor activity.",285.37,"152095-12-0",{"v":57,"d":"57.00"},199.74,"<1","N/A","http://selleckchem.com/products/dp44mt.html","C14H15N5S","free base","N/A","CN(C)C(=S)N\\N=C(/C1=NC=CC=C1)C2=CC=CC=N2",2.968,3,1,5]
["S7910","Epacadostat (INCB024360)","e9","L3000-32","in 10mM DMSO","IDO/TDO","Metabolism","Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).",438.23,"1204669-58-8",{"v":87,"d":"87.00"},198.53,"<1","N/A","http://selleckchem.com/products/epacadostat-incb024360.html","C11H13BrFN7O4S","free base","N/A","N[S](=O)(=O)NCCNC1=NON=C1C(NO)=NC2=CC(=C(F)C=C2)Br",0.378,6,4,8]
["S7911","BMS-1 (PD-1/PD-L1 inhibitor 1)","f9","L3000-32","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.",475.58,"1675201-83-8",{"v":95,"d":"95.00"},199.76,{"v":95,"d":"95.00"},199.76,"http://selleckchem.com/products/pd-1-pd-l1-inhibitor-1.html","C29H33NO5","free base","PD1-PDL1-IN1","COC1=CC(=CC(=C1CN2CCCCC2C(O)=O)OC)OCC3=C(C)C(=CC=C3)C4=CC=CC=C4",2.941,4,0,9]
["S7912","BMS202 (PD-1/PD-L1 inhibitor 2)","g9","L3000-32","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","BMS202 (PD-1/PD-L1 inhibitor 2) is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.",419.52,"1675203-84-5",{"v":83,"d":"83.00"},197.85,"<1","N/A","http://selleckchem.com/products/pd-1-pd-l1-inhibitor-2.html","C25H29N3O3","free base","N/A","COC1=C(CNCCNC(C)=O)C=CC(=N1)OCC2=C(C)C(=CC=C2)C3=CC=CC=C3",4.043,4,2,10]
["S7913","MCB-613","h9","L3000-32","in 10mM DMSO","ROS","ER stress & UPR","MCB-613 is a potent steroid receptor coactivator (SRC) stimulator.",304.39,"1162656-22-5",{"v":60,"d":"60.00"},197.12,"<1","N/A","http://selleckchem.com/products/mcb-613.html","C20H20N2O","free base","N/A","CCC1C\\C(=C/C2=CC=CN=C2)C(=O)C(/C1)=C/C3=CN=CC=C3",3.544,3,0,3]
["S7914","Isoxazole 9 (ISX-9)","a10","L3000-32","in 10mM DMSO","TGF-beta/Smad,Wnt/beta-catenin","Stem Cells & Wnt","Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.",234.27,"832115-62-5",{"v":46,"d":"46.00"},196.35,"<1","N/A","http://selleckchem.com/products/isoxazole-9-isx-9.html","C11H10N2O2S","free base","N/A","O=C(NC1CC1)C2=NOC(=C2)C3=CC=CS3",2.173,3,1,3]
["S7917","Kenpaullone","b10","L3000-32","in 10mM DMSO","CDK","Cell Cycle","Kenpaullone (9-Bromopaullone, NSC-664704) is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.",327.18,"142273-20-9",{"v":65,"d":"65.00"},198.67,"<1","N/A","http://selleckchem.com/products/kenpaullone.html","C16H11BrN2O","free base","9-Bromopaullone, NSC-664704","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3C=CC=C4)C=C1",3.671,1,2,0]
["S7918","Bromodeoxyuridine (BrdU)","c10","L3000-32","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bromodeoxyuridine (BrdU, 5-Bromo-2'-deoxyuridine, BUdR) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.",{"v":307.1,"d":"307.10"},"59-14-3",{"v":61,"d":"61.00"},198.63,"<1","N/A","http://selleckchem.com/products/bromodeoxyuridine-brdu.html","C9H11BrN2O5","free base","5-Bromo-2'-deoxyuridine, BUdR","OCC1OC(CC1O)N2C=C(Br)C(=O)NC2=O",-1.232,3,3,2]
["S7921","DEL-22379","d10","L3000-32","in 10mM DMSO","ERK","MAPK","DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.",444.53,"181223-80-3",{"v":89,"d":"89.00"},200.21,"<1","N/A","http://selleckchem.com/products/del-22379.html","C26H28N4O3","free base","N/A","COC1=CC2=C([NH]C=C2C=C3C(=O)NC4=CC=C(NC(=O)CCN5CCCCC5)C=C34)C=C1",{"v":3.3,"d":"3.300"},3,3,6]
["S7922","Tiplaxtinin (PAI-039)","e10","L3000-32","in 10mM DMSO","PAI-1","Metabolism","Tiplaxtinin(PAI-039) is an orally efficacious and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 μM.",439.38,"393105-53-8",{"v":72,"d":"72.00"},163.87,"<1","N/A","http://selleckchem.com/products/tiplaxtinin-pai-039.html","C24H16F3NO4","free base","N/A","OC(=O)C(=O)C1=C[N](CC2=CC=CC=C2)C3=CC=C(C=C13)C4=CC=C(OC(F)(F)F)C=C4",7.066,3,0,7]
["S7923","SH5-07 (SH-5-07)","f10","L3000-32","in 10mM DMSO","STAT","JAK/STAT","SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.",625.61,"1456632-41-9",{"v":100,"d":"100.00"},159.84,"<1","N/A","http://selleckchem.com/products/sh5-07.html","C29H28F5N3O5S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)NO)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",5.606,4,1,9]
["S7924","Bay K 8644","g10","L3000-32","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.",{"v":356.3,"d":"356.30"},"71145-03-4",{"v":71,"d":"71.00"},199.27,"<1","N/A","http://selleckchem.com/products/bay-k-8644.html","C16H15F3N2O4","free base","N/A","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)C(F)(F)F)[N+]([O-])=O)C",2.673,2,1,5]
["S7927","WZB117","h10","L3000-32","in 10mM DMSO","GLUT","Metabolism","WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM.",368.31,"1223397-11-2",{"v":73,"d":"73.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/wzb117.html","C20H13FO6","free base","N/A","OC1=CC=CC(=C1)C(=O)OC2=C(OC(=O)C3=CC=CC(=C3)O)C(=CC=C2)F",4.415,4,2,6]
["S7928","DASA-58","a11","L3000-32","in 10mM DMSO","PKM","Metabolism","DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.",453.53,"1203494-49-8",{"v":91,"d":"91.00"},200.65,"<1","N/A","http://selleckchem.com/products/dasa-58.html","C19H23N3O6S2","free base","N/A","NC1=CC(=CC=C1)[S](=O)(=O)N2CCCN(CC2)[S](=O)(=O)C3=CC4=C(OCCO4)C=C3",0.632,6,1,4]
["S7929","BEC HCl","b11","L3000-32","in 10mM DMSO","Arginase","Immunology & Inflammation","BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.",229.49,"222638-67-7",{"v":45,"d":"45.00"},196.09,{"v":45,"d":"45.00"},196.09,"http://selleckchem.com/products/bec-hydrochloride.html","C5H12BNO4S.HCl","hydrochloride salt","N/A","Cl.[NH3+]C(CSCCB(O)O)C([O-])=O",-2.415,0,0,6]
["S7931","STF-31","c11","L3000-32","in 10mM DMSO","GLUT","Metabolism","STF-31 is a selective glucose transporter GLUT1 inhibitor.",423.53,"724741-75-7",{"v":85,"d":"85.00"},200.69,"<1","N/A","http://selleckchem.com/products/stf-31.html","C23H25N3O3S","free base","N/A","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3",3.359,4,2,7]
["S7933","VR23","d11","L3000-32","in 10mM DMSO","Proteasome","Proteases","VR23 is a potent proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes, and caspase-like proteasomes, respectively.",477.88,"1624602-30-7",{"v":31,"d":"31.00"},64.87,"<1","N/A","http://selleckchem.com/products/vr23.html","C19H16ClN5O6S","free base","N/A","[O-][N+](=O)C1=CC=C(C(=C1)[N+]([O-])=O)[S](=O)(=O)N2CCN(CC2)C3=CC=NC4=CC(=CC=C34)Cl",3.215,3,0,5]
["S7934","SR9243","e11","L3000-32","in 10mM DMSO","Liver X Receptor","Metabolism","SR9243 is a potent and selective LXR inverse agonist.",626.62,"1613028-81-1",{"v":33,"d":"33.00"},52.66,"<1","N/A","http://www.selleck.cn/products/sr9243.html","C31H32BrNO4S2","Free Base","N/A","CC1=CC(=C(C(=C1)C)[S](=O)(=O)N(CCC2=CC=CC(=C2)Br)CC3=CC=C(C=C3)C4=CC(=CC=C4)[S](C)(=O)=O)C",7.686,4,0,9]
["S7935","Y-39983 HCl","f11","L3000-32","in 10mM DMSO","ROCK","Cell Cycle","Y-39983 HCl (Y-33075) is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.",353.25,"173897-44-4",{"v":63,"d":"63.00"},178.34,{"v":63,"d":"63.00"},178.34,"http://selleckchem.com/products/y-39983-hcl.html","C16H16N4O.2HCl","dihydrochloride","Y-33075 HCl","Cl.Cl.CC(N)C1=CC=C(C=C1)C(=O)NC2=C3C=C[NH]C3=NC=C2",2.204,2,3,3]
["S7936","Belumosudil (KD025)","g11","L3000-32","in 10mM DMSO","ROCK","Cell Cycle","Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.",452.51,"911417-87-3",{"v":90,"d":"90.00"},198.89,"<1","N/A","http://selleckchem.com/products/kd025-(slx-2119).html","C26H24N6O2","free base","SLx-2119","CC(C)NC(=O)COC1=CC(=CC=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C([NH]N=C5)C=C4",{"v":4.51,"d":"4.510"},5,3,7]
["S7937","Nemiralisib","h11","L3000-32","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).",440.54,"1254036-71-9",{"v":88,"d":"88.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk2269557.html","C26H28N6O","free base","GSK2269557","CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=CC(=CC4=C3C=N[NH]4)C5=CC=CC6=C5C=C[NH]6",3.943,3,2,5]
["S7940","NSC12","a2","L3000-33","in 10mM DMSO","FGFR","Angiogenesis","NSC12 (NSC 172285) is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity.",484.52,"102586-30-1",{"v":96,"d":"96.00"},198.13,"<1","N/A","http://selleckchem.com/products/nsc12.html","C24H34F6O3","free base","NSC 172285","CC12CCC3C(CC=C4CC(O)CCC34C)C1CCC2C(O)CC(O)(C(F)(F)F)C(F)(F)F",4.884,0,2,5]
["S7941","NCT-501","b2","L3000-33","in 10mM DMSO","Dehydrogenase","Metabolism","NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.",416.52,"1802088-50-1",{"v":32,"d":"32.00"},76.83,"<1","N/A","http://selleckchem.com/products/nct-501.html","C21H32N6O3","free base","N/A","CC(C)CC[N]1C(=NC2=C1C(=O)N(C)C(=O)N2C)CN3CCN(CC3)C(=O)C4CC4",1.722,4,0,6]
["S7942","Bioymifi","c2","L3000-33","in 10mM DMSO","TNF-alpha","Apoptosis","Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.",494.32,"1420071-30-2",{"v":43,"d":"43.00"},86.99,"<1","N/A","http://selleckchem.com/products/bioymifi.html","C22H12BrN3O4S","free base","N/A","BrC1=CC=C(C=C1)N2C(=N)S\\C(=C/C3=CC=C(O3)C4=CC=C5C(=O)NC(=O)C5=C4)C2=O",4.559,4,1,3]
["S7943","O4I1","d2","L3000-33","in 10mM DMSO","OCT","Transmembrane Transporters","O4I1 is a potent Oct3/4 inducer.",{"v":253.3,"d":"253.30"},"175135-47-4",{"v":51,"d":"51.00"},201.34,"<1","N/A","http://selleckchem.com/products/o4i1.html","C16H15NO2","free base","N/A","COC1=CC=C(COC2=CC=C(CC#N)C=C2)C=C1",3.294,2,0,5]
["S7944","O4I2","e2","L3000-33","in 10mM DMSO","OCT","Transmembrane Transporters","O4I2 is a potent Oct3/4 inducer, which is suitable for iPSC generation.",282.75,"165682-93-9",{"v":56,"d":"56.00"},198.05,"<1","N/A","http://selleckchem.com/products/o4i2.html","C12H11ClN2O2S","free base","N/A","CCOC(=O)C1=CSC(=N1)NC2=CC=C(Cl)C=C2",3.674,3,1,5]
["S7946","KC7F2","f2","L3000-33","in 10mM DMSO","HIF","Angiogenesis","KC7F2 is a selective HIF-1α translation inhibitor with IC50 of 20 μM in a cell-based assay.",570.38,"927822-86-4",{"v":100,"d":"100.00"},175.32,"<1","N/A","http://selleckchem.com/products/kc7f2.html","C16H16Cl4N2O4S4","free base","N/A","ClC1=CC(=C(Cl)C=C1)[S](=O)(=O)NCCSSCCN[S](=O)(=O)C2=CC(=CC=C2Cl)Cl",5.162,4,2,11]
["S7947","PX-12","g2","L3000-33","in 10mM DMSO","COVID-19,Thioredoxin","Metabolism","PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent thioredoxin-1 (Trx-1) inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.",188.31,"141400-58-0",{"v":38,"d":"38.00"},201.79,"<1","N/A","http://selleckchem.com/products/px-12.html","C7H12N2S2","free base","DB05448, 1-methyl propyl 2-imidazolyl disulfide","CCC(C)SSC1=NC=C[NH]1",2.641,1,1,4]
["S7951","Ochromycinone (STA-21)","h2","L3000-33","in 10mM DMSO","STAT","JAK/STAT","Ochromycinone (STA-21) is a selective STAT3 inhibitor.",306.31,"111540-00-2",{"v":21,"d":"21.00"},68.56,"<1","N/A","http://selleckchem.com/products/sta-21.html","C19H14O4","free base","N/A","CC1CC(=O)C2=C(C1)C=CC3=C2C(=O)C4=C(C(=CC=C4)O)C3=O",3.339,3,1,0]
["S7952","Ozanimod (RPC1063)","a3","L3000-33","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.",404.46,"1306760-87-1",{"v":81,"d":"81.00"},200.27,"<1","N/A","http://selleckchem.com/products/ozanimod-rpc1063.html","C23H24N4O3","free base","N/A","CC(C)OC1=CC=C(C=C1C#N)C2=NC(=NO2)C3=CC=CC4=C3CCC4NCCO",3.291,4,2,7]
["S7953","ETC-1002","b3","L3000-33","in 10mM DMSO","AMPK,ATP-citrate lyase,LDL","PI3K/Akt/mTOR","ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).",344.49,"738606-46-7",{"v":68,"d":"68.00"},197.39,"<1","N/A","http://selleckchem.com/products/etc-1002.html","C19H36O5","free base","Bempedoic acid, ESP-55016","CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O",{"v":5.18,"d":"5.180"},2,1,14]
["S7954","CP21R7 (CP21)","c3","L3000-33","in 10mM DMSO","GSK-3,Wnt/beta-catenin","Stem Cells & Wnt","CP21R7 (CP21) is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.",317.34,"125314-13-8",{"v":63,"d":"63.00"},198.53,"<1","N/A","http://selleckchem.com/products/cp21r7-cp21.html","C19H15N3O2","free base","N/A","C[N]1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CC=CC(=C4)N",2.315,2,2,2]
["S7955","EPI-001","d3","L3000-33","in 10mM DMSO","Androgen Receptor,PPAR","Endocrinology & Hormones","EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.",394.89,"227947-06-0",{"v":79,"d":"79.00"},200.06,"<1","N/A","http://selleckchem.com/products/epi-001.html","C21H27ClO5","free base","N/A","CC(C)(C1=CC=C(OCC(O)CO)C=C1)C2=CC=C(OCC(O)CCl)C=C2",3.334,2,3,10]
["S7958","Lificiguat (YC-1)","e3","L3000-33","in 10mM DMSO","Guanylate Cyclase,HIF","Angiogenesis","Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).",304.34,"170632-47-0",{"v":60,"d":"60.00"},197.15,"<1","N/A","http://selleckchem.com/products/lificiguat-yc-1.html","C19H16N2O2","free base","N/A","OCC1=CC=C(O1)C2=N[N](CC3=CC=CC=C3)C4=C2C=CC=C4",4.078,2,1,4]
["S7959","SIS3 HCl","f3","L3000-33","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.",489.99,"521984-48-5",{"v":97,"d":"97.00"},197.96,"<1","N/A","https://www.selleckchem.com/products/sis3-hcl.html","C28H27N3O3.HCl","hydrochloride","N/A","Cl.COC1=CC2=C(CN(CC2)C(=O)/C=C/C3=C([N](C)C4=NC=CC=C34)C5=CC=CC=C5)C=C1OC",5.076,4,0,5]
["S7960","Larotrectinib (LOXO-101) sulfate","g3","L3000-33","in 10mM DMSO","Apoptosis related,Trk receptor","Protein Tyrosine Kinase","Larotrectinib sulfate (LOXO-101, ARRY-470) is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). Larotrectinib inhibition of TRKs induces cellular apoptosis and G1 cell-cycle arrest.",526.51,"1223405-08-0",{"v":100,"d":"100.00"},189.93,"<1","N/A","http://selleckchem.com/products/loxo-101.html","C21H22F2N6O2.H2SO4","sulfate","ARRY-470, Larotrectinib","OC1CCN(C1)C(=O)NC2=C3N=C(C=C[N]3N=C2)N4CCCC4C5=CC(=CC=C5F)F.O[S](O)(=O)=O",1.374,3,2,3]
["S7963","TIC10 (ONC201)","h3","L3000-33","in 10mM DMSO","Akt,Apoptosis related,ERK,TNF-alpha","PI3K/Akt/mTOR","TIC10 (ONC201) inactivates Akt and ERK to induce TNF-related apoptosis-inducing ligand (TRAIL) through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"1616632-77-9",{"v":77,"d":"77.00"},199.23,"<1","N/A","http://selleckchem.com/products/tic-10.html","C24H26N4O","free base","ONC201","CC1=CC=CC=C1CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25",3.212,2,0,4]
["S7964","PLX7904","a4","L3000-33","in 10mM DMSO","Raf","MAPK","PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.",512.53,"1393465-84-3",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/plx7904.html","C24H22F2N6O3S","free base","PB04","CCN(C)[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CN=C(N=C4)C5CC5",2.291,6,2,8]
["S7965","PLX8394","b4","L3000-33","in 10mM DMSO","Raf","MAPK","PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.",542.53,"1393466-87-9",{"v":100,"d":"100.00"},184.32,"<1","N/A","http://www.selleckchem.com/products/plx8394.html","C25H21F3N6O3S","Free Base","N/A","FC1CCN(C1)[S](=O)(=O)NC2=CC=C(F)C(=C2F)C(=O)C3=C[NH]C4=NC=C(C=C34)C5=CN=C(N=C5)C6CC6",2.252,6,2,7]
["S7966","AZD8835","c4","L3000-33","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).",469.54,"1620576-64-8",{"v":93,"d":"93.00"},198.07,"<1","N/A","http://selleckchem.com/products/azd8835.html","C22H31N9O3","free base","N/A","CC[N]1N=C(N=C1C2=CN=C(N)C(=N2)C3=NN=C(O3)C(C)(C)C)C4CCN(CC4)C(=O)CCO",0.942,8,2,7]
["S7968","P7C3","d4","L3000-33","in 10mM DMSO","NAMPT","Metabolism","P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.",474.19,"301353-96-8",{"v":95,"d":"95.00"},200.34,"<1","N/A","http://selleckchem.com/products/p7c3.html","C21H18Br2N2O","free base","N/A","OC(CNC1=CC=CC=C1)C[N]2C3=C(C=C(Br)C=C3)C4=C2C=CC(=C4)Br",5.972,0,2,5]
["S7971","Zorifertinib (AZD3759)","e4","L3000-33","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Zorifertinib (AZD3759) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. Phase 1.",{"v":459.9,"d":"459.90"},"1626387-80-1",{"v":91,"d":"91.00"},197.87,"<1","N/A","http://selleckchem.com/products/azd3759.html","C22H23ClFN5O3","free base","N/A","COC1=C(OC(=O)N2CCN(C)CC2C)C=C3C(=NC=NC3=C1)NC4=CC=CC(=C4F)Cl",4.635,5,1,5]
["S7974","L755507","f4","L3000-33","in 10mM DMSO","Adrenergic Receptor,CRISPR/Cas9","GPCR & G Protein","L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.",584.73,"159182-43-1",{"v":100,"d":"100.00"},171.02,"<1","N/A","http://selleckchem.com/products/l755507.html","C30H40N4O6S","free base","N/A","CCCCCCNC(=O)NC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(CCNCC(O)COC3=CC=C(O)C=C3)C=C2",4.413,4,6,17]
["S7975","Favipiravir (T-705)","g4","L3000-33","in 10mM DMSO","COVID-19,DNA/RNA Synthesis,Influenza Virus","DNA Damage/DNA Repair","Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.",{"v":157.1,"d":"157.10"},"259793-96-9",{"v":31,"d":"31.00"},197.33,{"v":5,"d":"5.00"},31.83,"http://selleckchem.com/products/favipiravir-t-705.html","C5H4FN3O2","free base","N/A","NC(=O)C1=NC(=CN=C1O)F",-0.157,3,2,1]
["S7977","Napabucasin (BBI608)","h4","L3000-33","in 10mM DMSO","STAT","JAK/STAT","Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.",240.21,"83280-65-3",{"v":10,"d":"10.00"},41.63,"<1","N/A","http://selleckchem.com/products/napabucasin.html","C14H8O4","free base","BBI608","CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O",2.234,4,0,1]
["S7979","FG-2216","a5","L3000-33","in 10mM DMSO","HIF","Angiogenesis","FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.",280.66,"223387-75-5",{"v":56,"d":"56.00"},199.53,"<1","N/A","http://selleckchem.com/products/fg-2216.html","C12H9ClN2O4","free base","N/A","OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2C(=N1)Cl",1.337,3,2,3]
["S7980","VPS34-IN1","b5","L3000-33","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates autophagy.",425.91,"1383716-33-3",{"v":85,"d":"85.00"},199.57,"<1","N/A","http://selleckchem.com/products/vps34-in1.html","C21H24ClN7O","free base","Vps34-IN-1","CC(C)(O)CNC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC(=C4)Cl",3.672,5,2,8]
["S7983","A-196","c5","L3000-33","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.",359.25,"1982372-88-2",{"v":15,"d":"15.00"},41.75,"<1","N/A","http://selleckchem.com/products/a-196.html","C18H16Cl2N4","free base","N/A","ClC1=C(Cl)C=C2C(=C1)C(=NN=C2C3=CC=NC=C3)NC4CCCC4",4.995,3,1,3]
["S7992","LDC4297 (LDC044297)","d5","L3000-33","in 10mM DMSO","CDK","Cell Cycle","LDC4297 is a novel CDK7 inhibitor (IC50=0.13±0.06 nM for CDK7 versus IC50s between 10 nM and 10,000 nM for all other analyzed CDKs).",432.52,"1453834-21-3",{"v":86,"d":"86.00"},198.83,{"v":27,"d":"27.00"},62.42,"http://selleckchem.com/products/ldc4297-ldc044297.html","C23H28N8O","free base","N/A","CC(C)C1=C2N=C(OC3CCCNC3)N=C(NCC4=CC=CC=C4[N]5C=CC=N5)[N]2N=C1",3.928,5,2,7]
["S7993","SKF38393 HCl","e5","L3000-33","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.",291.77,"62717-42-4",{"v":58,"d":"58.00"},198.79,"<1","N/A","http://selleckchem.com/products/skf38393-hcl.html","C16H17NO2.HCl","Hydrochloride","N/A","Cl.OC1=C(O)C=C2C(CNCCC2=C1)C3=CC=CC=C3",3.013,0,3,1]
["S7998","Entrectinib (RXDX-101)","f5","L3000-33","in 10mM DMSO","ALK,Autophagy,ROS1,Trk receptor","Protein Tyrosine Kinase","Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.",560.64,"1108743-60-7",{"v":100,"d":"100.00"},178.37,"<1","N/A","http://selleckchem.com/products/entrectinib-rxdx-101.html","C31H34F2N6O2","free base","NMS-E628","CN1CCN(CC1)C2=CC=C(C(=O)NC3=N[NH]C4=C3C=C(CC5=CC(=CC(=C5)F)F)C=C4)C(=C2)NC6CCOCC6",4.952,3,3,7]
["S7999","SKF96365","g5","L3000-33","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8000","Tenovin-1","h5","L3000-33","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).",369.48,"380315-80-0",{"v":74,"d":"74.00"},200.28,"<1","N/A","http://selleckchem.com/products/tenovin-1.html","C20H23N3O2S","free base","N/A","CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",4.287,2,3,6]
["S8001","Ricolinostat (ACY-1215)","a6","L3000-33","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.",{"v":433.5,"d":"433.50"},"1316214-52-4",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/rocilinostat-acy-1215.html","C24H27N5O3","free base","Rocilinostat","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",3.917,4,2,11]
["S8002","GSK2636771","b6","L3000-33","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3Kβ with >900-fold selectivity over PI3Kα/PI3Kγ and >10-fold over PI3Kδ. Sensitive to PTEN null cell lines.",433.42,"1372540-25-4",{"v":28,"d":"28.00"},{"v":64.6,"d":"64.60"},"<1","N/A","http://selleckchem.com/products/gsk2636771.html","C22H22F3N3O3","free base","N/A","CC1=NC2=C(C=C(C=C2[N]1CC3=CC=CC(=C3C)C(F)(F)F)N4CCOCC4)C(O)=O",4.303,3,0,5]
["S8003","PQ 401","c6","L3000-33","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.",341.79,"196868-63-0",{"v":32,"d":"32.00"},93.62,"<1","N/A","http://selleckchem.com/products/pq-401.html","C18H16ClN3O2","free base","N/A","COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(=C2)C)C=C(Cl)C=C1",3.639,3,2,3]
["S8004","ZM 39923 HCl","d6","L3000-33","in 10mM DMSO","JAK","JAK/STAT","ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.",367.91,"1021868-92-7",{"v":30,"d":"30.00"},81.54,"<1","N/A","http://selleckchem.com/products/zm-39923-hcl.html","C23H25NO.HCl","HCl","N/A","Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC3=CC=CC=C3",5.424,1,0,7]
["S8005","SMI-4a","e6","L3000-33","in 10mM DMSO","Pim","JAK/STAT","SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.",273.23,"438190-29-5",{"v":55,"d":"55.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/smi-4a.html","C11H6F3NO2S","free base","TCS PIM-1 4a","FC(F)(F)C1=CC(=CC=C1)\\C=C2/SC(=O)NC2=O",2.884,2,1,2]
["S8006","BIX 01294","f6","L3000-33","in 10mM DMSO","Autophagy,G9a/GLP,Histone Methyltransferase,NSD","Epigenetics","BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.",600.02,"1392399-03-9",{"v":98,"d":"98.00"},163.33,{"v":98,"d":"98.00"},163.33,"http://selleckchem.com/products/bix-01294.html","C28H38N6O2.3HCl","trihydrochloride","N/A","Cl.Cl.Cl.COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)CC4=CC=CC=C4)N5CCCN(C)CC5",5.246,4,1,7]
["S8007","VE-821","g6","L3000-33","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.",368.41,"1232410-49-9",{"v":74,"d":"74.00"},200.86,"<1","N/A","http://selleckchem.com/products/ve-821.html","C18H16N4O3S","Free Base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)C2=CN=C(N)C(=N2)C(=O)NC3=CC=CC=C3",2.007,5,2,4]
["S8009","AG-18","h6","L3000-33","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG-18 (RG-50810, Tyrphostin A23, TX 825) inhibits EGFR with IC50 of 35 μM.",186.17,"118409-57-7",{"v":37,"d":"37.00"},198.74,"<1","N/A","http://selleckchem.com/products/ag-18-tyrphostin-23.html","C10H6N2O2","free base","RG-50810, Tyrphostin A23, TX 825","OC1=C(O)C=C(C=C1)C=C(C#N)C#N",1.531,0,2,1]
["S8014","GW9508","a7","L3000-33","in 10mM DMSO","GPR","Endocrinology & Hormones","GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.",347.41,"885101-89-3",{"v":69,"d":"69.00"},198.61,"<1","N/A","http://selleckchem.com/products/gw9508.html","C22H21NO3","free base","N/A","OC(=O)CCC1=CC=C(NCC2=CC=CC(=C2)OC3=CC=CC=C3)C=C1",4.903,2,1,8]
["S8015","Agerafenib (RXDX-105)","b7","L3000-33","in 10mM DMSO","c-Kit,c-RET,CSF-1R,PDGFR,Raf","MAPK","Agerafenib (RXDX-105, CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.",517.46,"1188910-76-0",{"v":9,"d":"9.00"},17.39,"<1","N/A","http://selleckchem.com/products/cep-32496.html","C24H22F3N5O5","free base","CEP-32496","COC1=CC2=NC=NC(=C2C=C1OC)OC3=CC(=CC=C3)NC(=O)NC4=NOC(=C4)C(C)(C)C(F)(F)F",5.288,8,2,8]
["S8016","Vonoprazan Fumarate (TAK-438)","c7","L3000-33","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.",461.46,"1260141-27-2",{"v":62,"d":"62.00"},134.36,"<1","N/A","http://selleckchem.com/products/tak-438.html","C17H16FN3O2S.C4H4O4","Fumarate","N/A","CNCC1=C[N](C(=C1)C2=CC=CC=C2F)[S](=O)(=O)C3=CC=CN=C3.OC(=O)\\C=C\\C(O)=O",0.017,5,1,7]
["S8018","Nirogacestat (PF-03084014)","d7","L3000-33","in 10mM DMSO","Apoptosis related,Secretase","Proteases","Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.",489.64,"1290543-63-3",{"v":97,"d":"97.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pf-03084014-pf-3084014.html","C27H41F2N5O","free base","PF-3084014","CCCC(NC1CCC2=CC(=CC(=C2C1)F)F)C(=O)NC3=C[N](C=N3)C(C)(C)CNCC(C)(C)C",5.042,2,3,11]
["S8019","Capivasertib (AZD5363)","e7","L3000-33","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.",428.92,"1143532-39-1",{"v":86,"d":"86.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://selleckchem.com/products/azd5363.html","C21H25ClN6O2","free base","N/A","NC1(CCN(CC1)C2=NC=NC3=C2C=C[NH]3)C(=O)NC(CCO)C4=CC=C(Cl)C=C4",1.317,3,4,6]
["S8020","GW0742","f7","L3000-33","in 10mM DMSO","PPAR","Metabolism","GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.",471.49,"317318-84-6",{"v":94,"d":"94.00"},199.37,"<1","N/A","http://selleckchem.com/products/gw0742.html","C21H17F4NO3S2","free base","N/A","CC1=CC(=CC=C1OCC(O)=O)SCC2=C(C)N=C(S2)C3=CC=C(C(=C3)F)C(F)(F)F",5.795,3,0,8]
["S8023","TCS 359","g7","L3000-33","in 10mM DMSO","FLT3","Angiogenesis","TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.",360.43,"301305-73-7",{"v":15,"d":"15.00"},41.62,"<1","N/A","http://selleckchem.com/products/tcs-359.html","C18H20N2O4S","free base","N/A","COC1=CC=C(C=C1OC)C(=O)NC2=C(C(N)=O)C3=C(CCCC3)S2",2.753,4,2,5]
["S8024","Tyrphostin AG 1296","h7","L3000-33","in 10mM DMSO","Apoptosis related,c-Kit,FGFR,PDGFR","Protein Tyrosine Kinase","Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.",266.29,"146535-11-7",{"v":6,"d":"6.00"},22.53,"<1","N/A","http://selleckchem.com/products/tyrphostin-ag-1296-ag-1296.html","C16H14N2O2","free base","AG 1296","COC1=CC2=NC=C(N=C2C=C1OC)C3=CC=CC=C3",3.208,4,0,3]
["S8025","GSK3787","a8","L3000-33","in 10mM DMSO","PPAR","Metabolism","GSK3787 is a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ.",392.78,"188591-46-0",{"v":79,"d":"79.00"},201.13,"<1","N/A","http://selleckchem.com/products/gsk3787.html","C15H12ClF3N2O3S","free base","N/A","FC(F)(F)C1=CC=C(N=C1)[S](=O)(=O)CCNC(=O)C2=CC=C(Cl)C=C2",3.207,4,1,6]
["S8028","Tariquidar (XR9576)","b8","L3000-33","in 10mM DMSO","P-gp","Transmembrane Transporters","Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.",646.73,"206873-63-4",{"v":52,"d":"52.00"},{"v":80.4,"d":"80.40"},"<1","N/A","http://selleckchem.com/products/tariquidar.html","C38H38N4O6","free base","XR9576","COC1=CC2=C(CN(CCC3=CC=C(NC(=O)C4=C(NC(=O)C5=CC6=CC=CC=C6N=C5)C=C(OC)C(=C4)OC)C=C3)CC2)C=C1OC",5.573,7,2,11]
["S8031","NSC 23766","c8","L3000-33","in 10mM DMSO","Rho","Cell Cycle","NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related  targets, Cdc42 or RhoA.",530.96,"1177865-17-6",{"v":100,"d":"100.00"},188.34,{"v":100,"d":"100.00"},188.34,"http://selleckchem.com/products/nsc-23766.html","C24H35N7.3HCl","HCl","N/A","Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(N)C=C(C)N=C3C=C2)C",5.477,3,3,10]
["S8032","PRT062607 (P505-15) HCl","d8","L3000-33","in 10mM DMSO","FAK,FLT3,Mixed Lineage Kinase,PAK,Pyk2,Src,Syk","Angiogenesis","PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.",429.91,"1370261-97-4",{"v":86,"d":"86.00"},200.04,{"v":86,"d":"86.00"},200.04,"http://selleckchem.com/products/prt062607-p505-15-hcl.html","C19H23N9O.HCl","Hydrochloride","BIIB057, PRT-2607","Cl.NC1CCCCC1NC2=NC=C(C(N)=O)C(=N2)NC3=CC(=CC=C3)[N]4N=CC=N4",2.033,5,4,6]
["S8034","Apremilast (CC-10004)","e8","L3000-33","in 10mM DMSO","PDE,TNF-alpha","Metabolism","Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.",{"v":460.5,"d":"460.50"},"608141-41-9",{"v":92,"d":"92.00"},199.78,"<1","N/A","http://selleckchem.com/products/apremilast-cc-10004.html","C22H24N2O7S","free base","CC-10004","CCOC1=C(OC)C=CC(=C1)C(C[S](C)(=O)=O)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(C)=O",1.509,7,1,8]
["S8036","Butein","f8","L3000-33","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.",272.25,"487-52-5",{"v":55,"d":"55.00"},202.02,"<1","N/A","http://selleckchem.com/products/butein.html","C15H12O5","free base","N/A","OC1=CC(=C(C=C1)C(=O)\\C=C\\C2=CC(=C(O)C=C2)O)O",2.734,1,4,3]
["S8037","Necrostatin-1","g8","L3000-33","in 10mM DMSO","Apoptosis related,Autophagy,IDO/TDO,RIP kinase,TNF-alpha","Apoptosis","Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.",259.33,"4311-88-0",{"v":51,"d":"51.00"},196.66,"<1","N/A","http://selleckchem.com/products/necrostatin-1.html","C13H13N3OS","free base","Nec-1","CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S",2.472,1,2,2]
["S8038","UPF 1069","h8","L3000-33","in 10mM DMSO","PARP","DNA Damage/DNA Repair","UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.",279.29,"1048371-03-4",{"v":56,"d":"56.00"},200.51,"<1","N/A","http://selleckchem.com/products/upf-1069.html","C17H13NO3","free base","N/A","O=C(COC1=C2C=CNC(=O)C2=CC=C1)C3=CC=CC=C3",1.966,3,1,4]
["S8039","Zelavespib (PU-H71)","a9","L3000-33","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Zelavespib (PU-H71, NSC 750424) is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.",512.37,"873436-91-0",{"v":100,"d":"100.00"},195.17,{"v":34,"d":"34.00"},66.36,"http://selleckchem.com/products/pu-h71.html","C18H21IN6O2S","free base","NSC 750424","CC(C)NCCC[N]1C(=NC2=C(N)N=CN=C12)SC3=CC4=C(OCO4)C=C3I",3.162,5,2,7]
["S8040","GDC-0349","b9","L3000-33","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.",452.55,"1207360-89-1",{"v":91,"d":"91.00"},201.08,"<1","N/A","http://selleckchem.com/products/gdc-0349.html","C24H32N6O3","free base","RG-7603","CCNC(=O)NC1=CC=C(C=C1)C2=NC(=C3CCN(CC3=N2)C4COC4)N5CCOCC5C",1.982,5,2,5]
["S8041","Cobimetinib (GDC-0973)","c9","L3000-33","in 10mM DMSO","Apoptosis related,MEK","MAPK","Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.",531.31,"934660-93-2",{"v":100,"d":"100.00"},188.21,"<1","N/A","http://selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html","C21H21F3IN3O2","free base","RG7420,XL518","OC1(CN(C1)C(=O)C2=C(NC3=CC=C(I)C=C3F)C(=C(F)C=C2)F)C4CCCCN4",3.701,1,2,4]
["S8042","GW2580","d9","L3000-33","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","GW2580 (SC-203877) is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.",366.41,"870483-87-7",{"v":48,"d":"48.00"},{"v":131,"d":"131.00"},"<1","N/A","http://selleckchem.com/products/gw2580.html","C20H22N4O3","free base","SC-203877","COC1=CC=C(COC2=CC=C(CC3=C(N)N=C(N)N=C3)C=C2OC)C=C1",3.127,5,2,7]
["S8043","Scriptaid","e9","L3000-33","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Scriptaid (GCK 1026) is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.",326.35,"287383-59-9",{"v":65,"d":"65.00"},199.17,"<1","N/A","http://selleckchem.com/products/scriptaid.html","C18H18N2O4","free base","GCK 1026","ONC(=O)CCCCCN1C(=O)C2=C3C(=CC=C2)C=CC=C3C1=O",2.119,3,1,6]
["S8044","BMS-345541","f9","L3000-33","in 10mM DMSO","IκB/IKK","NF-κB","BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.",255.32,"445430-58-0",{"v":9,"d":"9.00"},35.25,"<1","N/A","http://selleckchem.com/products/bms-345541.html","C14H17N5","free base","N/A","CC1=CC=C2N=C(NCCN)C3=NC=C(C)[N]3C2=C1",1.472,2,2,3]
["S8048","Venetoclax (ABT-199)","g9","L3000-33","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.",868.44,"1257044-40-8",{"v":100,"d":"100.00"},115.15,"<1","N/A","http://selleckchem.com/products/abt-199.html","C45H50ClN7O7S","free base","GDC-0199","CC1(C)CCC(=C(C1)C2=CC=C(Cl)C=C2)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)N[S](=O)(=O)C5=CC=C(NCC6CCOCC6)C(=C5)[N+]([O-])=O)OC7=CN=C8[NH]C=CC8=C7",{"v":7.94,"d":"7.940"},6,3,13]
["S8049","Tubastatin A","h9","L3000-33","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.",{"v":335.4,"d":"335.40"},"1252003-15-8",{"v":67,"d":"67.00"},199.76,"<1","N/A","https://www.selleckchem.com/products/tubastatin-a.html","C20H21N3O2","N/A","N/A","CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=C(C=C4)C(=O)NO",3.081,1,1,3]
["S8050","ETP-46464","a10","L3000-33","in 10mM DMSO","ATM/ATR,mTOR","PI3K/Akt/mTOR","ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.",470.52,"1345675-02-6",{"v":6,"d":"6.00"},12.75,"<1","N/A","http://selleckchem.com/products/etp-46464.html","C30H22N4O2","free base","N/A","CC(C)(C#N)C1=CC=C(C=C1)N2C(=O)OCC3=C2C4=C(C=CC(=C4)C5=CN=C6C=CC=CC6=C5)N=C3",5.813,4,0,3]
["S8051","Macitentan (ACT 064992)","b10","L3000-33","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Macitentan (ACT 064992) is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.",588.27,"441798-33-0",{"v":100,"d":"100.00"},169.99,"<1","N/A","http://selleckchem.com/products/macitentan.html","C19H20Br2N6O4S","free base","ACT 064992","CCCN[S](=O)(=O)NC1=NC=NC(=C1C2=CC=C(Br)C=C2)OCCOC3=NC=C(Br)C=N3",3.671,8,2,11]
["S8054","ASP3026","c10","L3000-33","in 10mM DMSO","ALK","Protein Tyrosine Kinase","ASP3026 is a novel and selective inhibitor for ALK  with IC50 of 3.5 nM. Phase 1.",580.74,"1097917-15-1",{"v":14,"d":"14.00"},24.11,"<1","N/A","http://selleckchem.com/products/asp3026.html","C29H40N8O3S","free base","N/A","COC1=CC(=CC=C1NC2=NC(=NC=N2)NC3=CC=CC=C3[S](=O)(=O)C(C)C)N4CCC(CC4)N5CCN(C)CC5",4.554,6,2,9]
["S8056","Lomeguatrib","d10","L3000-33","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.",326.17,"192441-08-0",{"v":65,"d":"65.00"},199.28,"<1","N/A","http://selleckchem.com/products/lomeguatrib.html","C10H8BrN5OS","free base","PaTrin-2","NC1=NC2=C([NH]C=N2)C(=N1)OCC3=CC(=CS3)Br",2.131,4,2,3]
["S8057","Pacritinib (SB1518)","e10","L3000-33","in 10mM DMSO","FLT3,JAK","JAK/STAT","Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.",472.58,"937272-79-2",{"v":11,"d":"11.00"},23.28,"<1","N/A","http://selleckchem.com/products/pacritinib-sb1518.html","C28H32N4O3","free base","N/A","C1CCN(C1)CCOC2=CC=C3NC4=NC=CC(=N4)C5=CC(=CC=C5)COC\\C=C\\COCC2=C3",4.547,5,1,4]
["S8058","Riviciclib hydrochloride (P276-00)","f10","L3000-33","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Riviciclib hydrochloride (P276-00) induces apoptosis. Phase 2/3.",{"v":438.3,"d":"438.30"},"920113-03-7",{"v":88,"d":"88.00"},200.78,{"v":88,"d":"88.00"},200.78,"http://selleckchem.com/products/p276-00.html","C21H20ClNO5.HCl","hydrochloride","N/A","Cl.CN1CCC(C1CO)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,3]
["S8061","Sabutoclax","g10","L3000-33","in 10mM DMSO","Bcl-2","Apoptosis","Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50  of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.",700.78,"1228108-65-3",{"v":100,"d":"100.00"},{"v":142.7,"d":"142.70"},"<1","N/A","http://selleckchem.com/products/sabutoclax.html","C42H40N2O8","free base","BI-97C1","CC(CNC(=O)C1=C(O)C(=CC2=C1C=C(C)C(=C2O)C3=C(O)C4=CC(=C(O)C(=C4C=C3C)C(=O)NCC(C)C5=CC=CC=C5)O)O)C6=CC=CC=C6",7.549,2,8,9]
["S8065","Nutlin-3b","h10","L3000-33","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8067","Vorapaxar (MK-5348)","a11","L3000-33","in 10mM DMSO","PAR","GPCR & G Protein","Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.",492.58,"618385-01-6",{"v":99,"d":"99.00"},200.98,"<1","N/A","http://selleckchem.com/products/vorapaxar.html","C29H33FN2O4","free base","SCH 530348","CCOC(=O)NC1CCC2C(C1)CC3C(C(C)OC3=O)C2\\C=C\\C4=CC=C(C=N4)C5=CC=CC(=C5)F",5.261,5,1,6]
["S8068","Chaetocin","b11","L3000-33","in 10mM DMSO","Anti-infection,G9a/GLP,Histone Methyltransferase,Thioredoxin Reductase","Epigenetics","Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).",696.84,"28097-03-2",{"v":100,"d":"100.00"},{"v":143.5,"d":"143.50"},"<1","N/A","http://selleckchem.com/products/chaetocin.html","C30H28N6O6S4","free base","N/A","CN1C(=O)C23CC4(C(NC5=C4C=CC=C5)N2C(=O)C1(CO)SS3)C67CC89SSC(CO)(N(C)C8=O)C(=O)N9C6NC%10=C7C=CC=C%10",1.621,4,4,3]
["S8071","UNC0638","c11","L3000-33","in 10mM DMSO","Antiviral,G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.",509.73,"1255580-76-7",{"v":100,"d":"100.00"},196.18,{"v":6,"d":"6.00"},11.77,"http://selleckchem.com/products/unc0638.html","C30H47N5O2","free base","N/A","COC1=CC2=C(NC3CCN(CC3)C(C)C)N=C(N=C2C=C1OCCCN4CCCC4)C5CCCCC5",5.284,4,1,10]
["S8072","NSC 405020","d11","L3000-33","in 10mM DMSO","MMP","Proteases","NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.",260.16,"7497-07-6",{"v":52,"d":"52.00"},199.88,"<1","N/A","http://selleckchem.com/products/nsc-405020.html","C12H15Cl2NO","free base","N/A","CCCC(C)NC(=O)C1=CC=C(Cl)C(=C1)Cl",4.073,1,1,4]
["S8073","Optovin","e11","L3000-33","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Optovin is a reversible photoactivated TRPA1 activator.",315.41,"348575-88-2",{"v":63,"d":"63.00"},199.74,"<1","N/A","http://selleckchem.com/products/optovin.html","C15H13N3OS2","free base","N/A","CC1=CC(=C(C)[N]1C2=CC=CN=C2)\\C=C3\\SC(=S)NC3=O",2.858,2,1,2]
["S8076","PluriSIn #1 (NSC 14613)","f11","L3000-33","in 10mM DMSO","SCD","Metabolism","PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.",213.24,"91396-88-2",{"v":43,"d":"43.00"},201.65,"<1","N/A","http://selleckchem.com/products/PluriSIn-1-nsc-14613.html","C12H11N3O","free base","N/A","O=C(NNC1=CC=CC=C1)C2=CC=NC=C2",1.486,2,2,3]
["S8077","RI-1","g11","L3000-33","in 10mM DMSO","RAD51","DNA Damage/DNA Repair","RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.",361.61,"415713-60-9",{"v":50,"d":"50.00"},138.27,"<1","N/A","http://selleckchem.com/products/ri-1.html","C14H11Cl3N2O3","free base","RAD51 inhibitor 1","ClC1=CC=C(C=C1Cl)N2C(=O)C(=C(N3CCOCC3)C2=O)Cl",2.544,3,0,2]
["S8078","Bardoxolone Methyl","h11","L3000-33","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8094","GlyH-101","a2","L3000-34","in 10mM DMSO","CFTR","Transmembrane Transporters","GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.",493.15,"328541-79-3",{"v":98,"d":"98.00"},198.72,"<1","N/A","http://selleckchem.com/products/glyh-101.html","C19H15Br2N3O3","free base","N/A","OC1=C(Br)C(=C(/C=N/NC(=O)CNC2=CC3=CC=CC=C3C=C2)C=C1Br)O",4.265,2,4,5]
["S8095","Tubercidin","b2","L3000-34","in 10mM DMSO","DNA/RNA Synthesis,Fungal","DNA Damage/DNA Repair","Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.",266.25,"69-33-0",{"v":53,"d":"53.00"},199.06,"<1","N/A","http://selleckchem.com/products/tubercidin.html","C11H14N4O4","free base","7-deaza-adenosine","NC1=NC=NC2=C1C=C[N]2C3OC(CO)C(O)C3O",-1.103,3,4,2]
["S8096","Mirin","c2","L3000-34","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. Mirin inhibits MRN-dependent activation of ATM.",220.25,"1198097-97-0",{"v":44,"d":"44.00"},199.77,"<1","N/A","http://selleckchem.com/products/mirin.html","C10H8N2O2S","free base","N/A","OC1=CC=C(C=C1)\\C=C2/SC(=N)NC2=O",1.754,1,2,1]
["S8097","C-DIM12","d2","L3000-34","in 10mM DMSO","Dopamine Receptor,Immunology & Inflammation related","Neuronal Signaling","C-DIM12 is a Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.",356.85,"178946-89-9",{"v":71,"d":"71.00"},198.96,"<1","N/A","http://selleckchem.com/products/c-dim12.html","C23H17ClN2","free base","N/A","ClC1=CC=C(C=C1)C(C2=C[NH]C3=C2C=CC=C3)C4=C[NH]C5=C4C=CC=C5",6.339,0,2,3]
["S8100","K03861","e2","L3000-34","in 10mM DMSO","CDK","Cell Cycle","K03861 (AUZ 454，AUZ454) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.",{"v":501.5,"d":"501.50"},"853299-07-7",{"v":100,"d":"100.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://selleckchem.com/products/k03861.html","C24H26F3N7O2","free base","AUZ 454，AUZ454","CN1CCN(CC1)CC2=CC=C(NC(=O)NC3=CC=C(OC4=NC(=NC=C4)N)C=C3)C=C2C(F)(F)F",3.591,4,3,7]
["S8101","CB-5083","f2","L3000-34","in 10mM DMSO","ATPase,p97","Transmembrane Transporters","CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.",413.47,"1542705-92-9",{"v":82,"d":"82.00"},198.32,"<1","N/A","http://selleckchem.com/products/cb-5083.html","C24H23N5O2","free base","N/A","CC1=CC2=C(C=CC=C2C(N)=O)[N]1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5",3.748,4,2,5]
["S8102","Z-VAD(OH)-FMK (Caspase Inhibitor VI)","g2","L3000-34","in 10mM DMSO","Caspase","Apoptosis","Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.",453.46,"161401-82-7",{"v":90,"d":"90.00"},198.47,"<1","N/A","http://selleckchem.com/products/z-vad(oh)-fmk.html","C21H28FN3O7","free base","N/A","CC(C)C(NC(=O)OCC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC(O)=O)C(=O)CF",1.246,6,3,13]
["S8104","SCH58261","h2","L3000-34","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.",345.36,"160098-96-4",{"v":69,"d":"69.00"},199.79,"<1","N/A","http://selleckchem.com/products/sch58261.html","C18H15N7O","free base","N/A","NC1=NC2=C(C=N[N]2CCC3=CC=CC=C3)C4=NC(=N[N]14)C5=CC=CO5",{"v":2.74,"d":"2.740"},5,1,4]
["S8105","ZM241385","a3","L3000-34","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.",337.34,"139180-30-6",{"v":67,"d":"67.00"},198.61,"<1","N/A","http://selleckchem.com/products/zm241385.html","C16H15N7O2","free base","N/A","NC1=NC(=NC2=NC(=N[N]12)C3=CC=CO3)NCCC4=CC=C(O)C=C4",2.917,5,3,5]
["S8106","NSC59984","b3","L3000-34","in 10mM DMSO","p53","Apoptosis","NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.",265.27,"803647-40-7",{"v":53,"d":"53.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/nsc59984.html","C12H15N3O4","free base","N/A","CN1CCN(CC1)C(=O)\\C=C\\C2=CC=C(O2)[N+]([O-])=O",1.083,2,0,3]
["S8111","GSK591","c3","L3000-34","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.",380.48,"1616391-87-7",{"v":76,"d":"76.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk591-epz015866-gsk3203591.html","C22H28N4O2","free base","EPZ015866, GSK3203591","OC(CNC(=O)C1=CC(=NC=C1)NC2CCC2)CN3CCC4=C(C3)C=CC=C4",2.467,2,3,7]
["S8112","MS023","d3","L3000-34","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.",{"v":287.4,"d":"287.40"},"1831110-54-3",{"v":57,"d":"57.00"},198.33,"<1","N/A","http://selleckchem.com/products/ms023.html","C17H25N3O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[NH]C=C2CN(C)CCN",2.396,1,2,7]
["S8116","Acalabrutinib (ACP-196)","e3","L3000-34","in 10mM DMSO","BTK","Angiogenesis","Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.",465.51,"1420477-60-6",{"v":93,"d":"93.00"},199.78,"<1","N/A","http://selleckchem.com/products/acalabrutinib.html","C26H23N7O2","free base","N/A","CC#CC(=O)N1CCCC1C2=NC(=C3[N]2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC=C5",2.699,5,2,5]
["S8117","GMX1778 (CHS828)","f3","L3000-34","in 10mM DMSO","Apoptosis related,NAMPT","Metabolism","GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.",371.86,"200484-11-3",{"v":74,"d":"74.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/gmx1778-chs828.html","C19H22ClN5O","free base","N/A","ClC1=CC=C(OCCCCCCNC(NC2=CC=NC=C2)=NC#N)C=C1",{"v":3.84,"d":"3.840"},3,2,11]
["S8118","RHPS 4 methosulfate","g3","L3000-34","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.",458.48,"390362-78-4",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/rhps4-nsc714187.html","C22H17F2N2.CH3O4S","methyl sulfate","NSC714187","CO[S]([O-])(=O)=O.CN1C2=CC=C(F)C=C2C3=[N+](C)C4=C(C=C(F)C=C4)C5=CC(=CC1=C35)C",3.363,1,0,1]
["S8125","Pamapimod","h3","L3000-34","in 10mM DMSO","p38 MAPK","MAPK","Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.",406.38,"449811-01-2",{"v":81,"d":"81.00"},199.32,"<1","N/A","http://selleckchem.com/products/pamapimod-r-1503-ro4402257.html","C19H20F2N4O4","free base","R-1503,Ro4402257","CN1C(=O)C(=CC2=CN=C(NC(CCO)CCO)N=C12)OC3=C(F)C=C(F)C=C3",1.298,4,3,8]
["S8132","Deguelin","a4","L3000-34","in 10mM DMSO","Akt,PI3K","PI3K/Akt/mTOR","Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an  PI3K/AKT Inhibitor.",394.42,"522-17-8",{"v":78,"d":"78.00"},197.76,"<1","N/A","http://selleckchem.com/products/deguelin.html","C23H22O6","free base","(-)-Deguelin, (-)-cis-Deguelin","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C5C=CC(C)(C)OC5=CC=C4C3=O",3.567,6,0,2]
["S8133","Resiquimod (R-848)","b4","L3000-34","in 10mM DMSO","HCV,IFN,Interleukins,TLR,TNF-alpha","Immunology & Inflammation","Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2.",314.38,"144875-48-9",{"v":63,"d":"63.00"},200.39,"<1","N/A","http://selleckchem.com/products/resiquimod.html","C17H22N4O2","free base","S28463","CCOCC1=NC2=C([N]1CC(C)(C)O)C3=C(C=CC=C3)N=C2N",1.919,3,1,5]
["S8134","Radotinib","c4","L3000-34","in 10mM DMSO","Bcr-Abl","Angiogenesis","Radotinib (IY-5511) is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.",{"v":530.5,"d":"530.50"},"926037-48-1",{"v":100,"d":"100.00"},{"v":188.5,"d":"188.50"},"<1","N/A","http://selleckchem.com/products/radotinib.html","C27H21F3N8O","free base","IY-5511","CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=NC=CN=C5",4.362,6,2,7]
["S8135","Riociguat (BAY 63-2521)","d4","L3000-34","in 10mM DMSO","Guanylate Cyclase","GPCR & G Protein","Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.",422.42,"625115-55-1",{"v":84,"d":"84.00"},198.85,"<1","N/A","http://selleckchem.com/products/riociguat-bay-63-2521.html","C20H19FN8O2","free base","N/A","COC(=O)N(C)C1=C(N)N=C(N=C1N)C2=N[N](CC3=CC=CC=C3F)C4=NC=CC=C24",2.341,6,2,5]
["S8136","Sivelestat (ONO-5046)","e4","L3000-34","in 10mM DMSO","Serine Protease","Proteases","Sivelestat (ONO5046, LY544349, EI546) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.",434.46,"127373-66-4",{"v":86,"d":"86.00"},197.95,"<1","N/A","http://selleckchem.com/products/sivelestat-ono-5046.html","C20H22N2O7S","Free Base","ONO5046, LY544349, EI546","CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC(O)=O",2.321,6,2,9]
["S8137","Capsazepine","f4","L3000-34","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Capsazepine acts as a competitive antagonist of capsaicin and a transient receptor potential vanilloid type 1(TRPV1) antagonist. If you want to do cell experiments, please select batch 01.",{"v":376.9,"d":"376.90"},"138977-28-3",{"v":75,"d":"75.00"},198.99,"<1","N/A","http://selleckchem.com/products/capsazepine.html","C19H21ClN2O2S","free base","N/A","OC1=CC2=C(CN(CCC2)C(=S)NCCC3=CC=C(Cl)C=C3)C=C1O",5.393,0,3,5]
["S8140","GNF-7","g4","L3000-34","in 10mM DMSO","Bcr-Abl","Angiogenesis","GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.",547.53,"839706-07-9",{"v":20,"d":"20.00"},36.53,"<1","N/A","http://selleckchem.com/products/gnf-7.html","C28H24F3N7O2","free base","N/A","CN1C(=O)N(CC2=CN=C(NC3=CC=C(C)N=C3)N=C12)C4=CC(=CC=C4C)NC(=O)C5=CC=CC(=C5)C(F)(F)F",4.864,5,2,6]
["S8141","Cl-amidine","h4","L3000-34","in 10mM DMSO","Apoptosis related,Immunology & Inflammation related,PAD","Immunology & Inflammation","Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis.",{"v":424.8,"d":"424.80"},"1043444-18-3",{"v":84,"d":"84.00"},197.74,{"v":70,"d":"70.00"},164.78,"http://selleckchem.com/products/cl-amidine.html","C14H19ClN4O2.C2HF3O2","trifluoroacetate","N/A","NC(=O)C(CCCNC(=N)CCl)NC(=O)C1=CC=CC=C1.OC(=O)C(F)(F)F",1.333,3,3,10]
["S8144","Halofuginone","a5","L3000-34","in 10mM DMSO","DNA/RNA Synthesis,TGF-beta/Smad","DNA Damage/DNA Repair","Halofuginone (RU-19110) is the competitively inhibitor of  prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.",414.68,"55837-20-2",{"v":20,"d":"20.00"},48.23,"<1","N/A","http://selleckchem.com/products/halofuginone.html","C16H17BrClN3O3","free base","RU-19110","OC1CCCNC1CC(=O)CN2C=NC3=CC(=C(Cl)C=C3C2=O)Br",1.648,3,2,4]
["S8148","PD0166285","b5","L3000-34","in 10mM DMSO","Apoptosis related,Chk,Wee1","Cell Cycle","PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.",512.43,"185039-89-8",{"v":100,"d":"100.00"},195.15,"<1","N/A","http://selleckchem.com/products/pd0166285.html","C26H27Cl2N5O2","free base","N/A","CCN(CC)CCOC1=CC=C(NC2=NC3=C(C=N2)C=C(C(=O)N3C)C4=C(Cl)C=CC=C4Cl)C=C1",5.917,4,1,9]
["S8149","NSC348884","c5","L3000-34","in 10mM DMSO","Apoptosis related,p53","Apoptosis","NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.",636.79,"81624-55-7",{"v":100,"d":"100.00"},157.04,"<1","N/A","http://selleckchem.com/products/nsc348884.html","C38H40N10","free base","N/A","CC1=CC2=C(C=C1)N=C(CN(CCN(CC3=NC4=C([NH]3)C=C(C)C=C4)CC5=NC6=C([NH]5)C=C(C)C=C6)CC7=NC8=C([NH]7)C=C(C)C=C8)[NH]2",7.572,4,4,11]
["S8155","RSL3","d5","L3000-34","in 10mM DMSO","Ferroptosis,Peroxidases","Metabolism","RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.",440.88,"1219810-16-8",{"v":88,"d":"88.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/rsl3.html","C23H21ClN2O5","free base","(1S,3R)-RSL3","COC(=O)C1CC2=C([NH]C3=C2C=CC=C3)C(N1C(=O)CCl)C4=CC=C(C=C4)C(=O)OC",3.558,5,1,6]
["S8156","ARS-853 (ARS853)","e5","L3000-34","in 10mM DMSO","Apoptosis related,Ras","Cell Cycle","ARS-853 is a selective, covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. ARS-853 also induces apoptosis.",432.94,"1629268-00-3",{"v":86,"d":"86.00"},198.64,"<1","N/A","http://selleckchem.com/products/ars-853.html","C22H29ClN4O3","free base","N/A","CC1(CC1)C2=C(Cl)C=C(O)C(=C2)NCC(=O)N3CCN(CC3)C4CN(C4)C(=O)C=C",2.256,2,2,6]
["S8157","GDC-0326","f5","L3000-34","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GDC-0326 is a potent and selective inhibitor of PI3Kα with Ki value of 0.2 nM; remarkably selective over the other class I isoforms in enzymatic assays.",382.42,"1282514-88-8",{"v":76,"d":"76.00"},198.73,"<1","N/A","http://selleckchem.com/products/gdc-0326.html","C19H22N6O3","free base","N/A","CC(C)[N]1N=CN=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)OC(C)C(N)=O",2.017,6,1,5]
["S8161","ON123300","g5","L3000-34","in 10mM DMSO","AMPK,CDK,c-RET,FGFR,PDGFR,Src","Cell Cycle","ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn, respectively.",429.52,"1357470-29-1",{"v":29,"d":"29.00"},67.52,"<1","N/A","http://selleckchem.com/products/on123300.html","C24H27N7O","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C4C=C(C#N)C(=O)N(C5CCCC5)C4=N3)C=C2",{"v":3.65,"d":"3.650"},3,1,4]
["S8163","Paxalisib (GDC-0084)","h5","L3000-34","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.",382.42,"1382979-44-3",{"v":8,"d":"8.00"},20.92,"<1","N/A","http://selleckchem.com/products/gdc-0084.html","C18H22N8O2","free base","RG7666","CC1(C)OCC[N]2C3=C(N=C12)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",0.588,7,1,2]
["S8165","Cucurbitacin B","a6","L3000-34","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of microtubule polymerization.",{"v":558.7,"d":"558.70"},"6199-67-3",{"v":100,"d":"100.00"},178.99,"<1","N/A","http://selleckchem.com/products/cucurbitacin-b.html","C32H46O8","free base","N/A","CC(=O)OC(C)(C)/C=C/C(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C",2.312,5,2,6]
["S8166","tirabrutinib(ONO-4059) hydrochloride","b6","L3000-34","in 10mM DMSO","BTK","Angiogenesis","Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with an IC50 of 2.2 nM.",490.94,"1439901-97-9",{"v":98,"d":"98.00"},199.62,"<1","N/A","http://selleckchem.com/products/ono-4059-gs-4059.html","C25H22N6O3.HCl","hydrochloride","GS-4059","Cl.CC#CC(=O)N1CCC(C1)N2C(=O)N(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C25",3.706,5,1,5]
["S8167","AMG 337","c6","L3000-34","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM.",463.46,"1173699-31-4",{"v":95,"d":"95.00"},204.98,"<1","N/A","http://selleckchem.com/products/amg-337.html","C23H22FN7O3","free base","N/A","COCCOC1=CC2=C(C=CN(C(C)C3=NN=C4[N]3C=C(C=C4F)C5=C[N](C)N=C5)C2=O)N=C1",1.188,7,0,7]
["S8171","Daprodustat (GSK1278863)","d6","L3000-34","in 10mM DMSO","HIF","Angiogenesis","Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.",393.43,"960539-70-2",{"v":10,"d":"10.00"},25.42,"<1","N/A","http://selleckchem.com/products/daprodustat.html","C19H27N3O6","free base","N/A","OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C3CCCCC3)C1=O",1.747,5,1,5]
["S8172","Ro 61-8048","e6","L3000-34","in 10mM DMSO","Hydroxylase","Metabolism","Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.",421.45,"199666-03-0",{"v":84,"d":"84.00"},199.31,"<1","N/A","http://selleckchem.com/products/ro-61-8048.html","C17H15N3O6S2","free base","N/A","COC1=C(OC)C=C(C=C1)[S](=O)(=O)NC2=NC(=CS2)C3=CC=CC(=C3)[N+]([O-])=O",3.123,5,1,7]
["S8174","VO-Ohpic trihydrate","f6","L3000-34","in 10mM DMSO","PTEN","PI3K/Akt/mTOR","VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.",{"v":415.2,"d":"415.20"},"476310-60-8",{"v":72,"d":"72.00"},173.41,"<1","N/A","http://selleckchem.com/products/vo-ohpic.html","C12H9N2O8V.3H2O.H","trihydrate","N/A","O.O.O.OC1=CC=CN|2=C1C(=O)O[VH]3|2(O)(=O)OC(=O)C4=NC=CC=C4O3",-0.342,7,1,0]
["S8177","BH3I-1","g6","L3000-34","in 10mM DMSO","Bcl-2","Apoptosis","BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.",400.31,"300817-68-9",{"v":64,"d":"64.00"},159.88,"<1","N/A","http://selleckchem.com/products/bh3i-1.html","C15H14BrNO3S2","free base","N/A","CC(C)C(N1C(=S)S\\C(=C/C2=CC=C(Br)C=C2)C1=O)C(O)=O",4.604,2,0,4]
["S8179","BI-7273","h6","L3000-34","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BI-7273 is a potent, selective, and cell-permeable BRD9 BD inhibitor with IC50s of 19 nM and 117 nM for BRD9 and BRD7 respectively in alpha assay.",353.41,"1883429-21-7",{"v":70,"d":"70.00"},198.07,"<1","N/A","http://selleckchem.com/products/bi-7273.html","C20H23N3O3","free base","N/A","COC1=C(CN(C)C)C(=CC(=C1)C2=CN(C)C(=O)C3=C2C=CN=C3)OC",1.301,4,0,5]
["S8180","PF-CBP1 HCl","a7","L3000-34","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.",525.08,"2070014-93-4",{"v":100,"d":"100.00"},190.45,{"v":100,"d":"100.00"},190.45,"http://selleckchem.com/products/pf-cbp1.html","C29H36N4O3.HCl","Hydrochloride","N/A","Cl.CCCOC1=CC=C(CCC2=NC3=CC(=CC=C3[N]2CCN4CCOCC4)C5=C(C)ON=C5C)C=C1",5.432,5,0,10]
["S8181","SBI-0640756","b7","L3000-34","in 10mM DMSO","eIF","Cell Cycle","SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.",404.82,"1821280-29-8",{"v":80,"d":"80.00"},197.62,"<1","N/A","http://selleckchem.com/products/sbi-0640756.html","C23H14ClFN2O2","free base","N/A","FC1=CC(=CN=C1)\\C=C\\C(=O)C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(=C4)Cl",4.273,3,1,4]
["S8182","NSC87877","c7","L3000-34","in 10mM DMSO","phosphatase","Metabolism","NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.",503.42,"56932-43-5",{"v":100,"d":"100.00"},198.64,{"v":100,"d":"100.00"},198.64,"http://selleckchem.com/products/nsc87877.html","C19H13N3O7S2.2Na","sodium salt","N/A","OC1=C2N=CC=CC2=C(C=C1N=NC3=CC4=CC=C(C=C4C=C3)[S](=O)(=O)O[Na])[S](=O)(=O)O[Na]",3.899,5,1,6]
["S8183","Pimavanserin tartrate","d7","L3000-34","in 10mM DMSO","5-HT Receptor","GPCR & G Protein","Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.",{"v":1005.2,"d":"1005.20"},"706782-28-7",{"v":100,"d":"100.00"},99.48,{"v":100,"d":"100.00"},99.48,"http://selleckchem.com/products/pimavanserin.html","C50H68F2N6O4.C4H6O6","tartrate","ACP-103","CC(C)COC1=CC=C(CNC(=O)N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)C=C1.CC(C)COC4=CC=C(CNC(=O)N(CC5=CC=C(F)C=C5)C6CCN(C)CC6)C=C4.OC(C(O)C(O)=O)C(O)=O",0.735,6,4,19]
["S8188","BFH772","e7","L3000-34","in 10mM DMSO","VEGFR","Angiogenesis","BFH772 is a novel potent oral VEGFR2 inhibitor, targeting VEGFR2 kinase with IC50 of 3 nM.",439.39,"890128-81-1",{"v":87,"d":"87.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/bfh772.html","C23H16F3N3O3","free base","BFH 772, BFH-772","OCC1=CC(=NC=N1)OC2=CC=C3C(=C2)C=CC=C3C(=O)NC4=CC(=CC=C4)C(F)(F)F",4.396,4,2,6]
["S8189","BAW2881 (NVP-BAW2881)","f7","L3000-34","in 10mM DMSO","c-RET,Raf,VEGFR","Protein Tyrosine Kinase","BAW2881 (NVP-BAW2881) is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor that potently inhibits VEGFR1-3 at 1.0-4.3 nanomolar (nM) concentrations and inhibits PDGFRβ, c-Kit, and RET (c-RET) at 45-72 nM concentrations.",424.38,"861875-60-7",{"v":84,"d":"84.00"},197.94,"<1","N/A","http://selleckchem.com/products/baw2881-nvp-baw2881.html","C22H15F3N4O2","free base","N/A","NC1=NC(=CC=N1)OC2=CC=C3C(=C2)C=CC=C3C(=O)NC4=CC(=CC=C4)C(F)(F)F",{"v":4.56,"d":"4.560"},4,2,5]
["S8190","CPI-637","g7","L3000-34","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM and 0.051μM for CBP and EP300 respectively in TR-FRET assay. It is highly selective against other bromodomains, displaying substantial biochemical activity only against BRD9.",386.45,"1884712-47-3",{"v":27,"d":"27.00"},69.87,"<1","N/A","http://selleckchem.com/products/cpi-637.html","C22H22N6O","free base","N/A","CC1CC(=O)NC2=C(N1)C(=CC=C2)C3=CC4=C(C=C3)[N](C)N=C4C5=C[N](C)N=C5",3.035,3,2,2]
["S8192","SUN11602","h7","L3000-34","in 10mM DMSO","FGFR","Angiogenesis","SUN11602 is a small synthetic compound that mimics the neuroprotective activities of bFGF and activates key molecules in the FGF receptor-1-mitogen-activated protein kinase/extracellular signal-regulated kinase-1/2 kinase (FGFR-1-MEK/ERK) signaling pathway.",{"v":451.6,"d":"451.60"},"704869-38-5",{"v":90,"d":"90.00"},199.29,"<1","N/A","http://selleckchem.com/products/sun11602.html","C26H37N5O2","free base","N/A","CN(C1CCN(CC1)CC2=CC=C(C=C2)C(N)=O)C(=O)CNC3=C(C)C(=C(N)C(=C3C)C)C",2.799,2,3,7]
["S8194","umbralisib (TGR-1202)","a8","L3000-34","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Umbralisib (TGR-1202, Rp-5264), a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively.",571.55,"1532533-67-7",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/tgr-1202.html","C31H24F3N5O3","free base","Rp-5264","CC(C)OC1=C(F)C=C(C=C1)C2=N[N](C(C)C3=C(C4=CC(=CC=C4)F)C(=O)C5=CC(=CC=C5O3)F)C6=C2C(=NC=N6)N",6.393,6,1,6]
["S8196","ML264","b8","L3000-34","in 10mM DMSO","KLF","MAPK","ML264 (CID-51003603), a selectively inhibitor of kruppel-like factor 5 (KLF5),potently Inhibits Growth of Colorectal Cancer.",384.88,"1550008-55-3",{"v":76,"d":"76.00"},197.46,"<1","N/A","http://selleckchem.com/products/ml264.html","C17H21ClN2O4S","free base","CID-51003603","CN(C1CC[S](=O)(=O)CC1)C(=O)CNC(=O)/C=C/C2=CC(=CC=C2)Cl",1.006,4,1,5]
["S8200","MK-4101","c8","L3000-34","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.",493.47,"935273-79-3",{"v":98,"d":"98.00"},198.59,"<1","N/A","http://selleckchem.com/products/mk-4101.html","C24H24F5N5O","free base","N/A","C[N]1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(F)(F)C5)C6=CC=CC=C6C(F)(F)F",4.784,5,0,5]
["S8201","BI-78D3","d8","L3000-34","in 10mM DMSO","JNK","MAPK","BI-78D3 is a competitive JNK inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.",379.37,"883065-90-5",{"v":100,"d":"100.00"},263.59,"<1","N/A","http://selleckchem.com/products/bi-78d3.html","C13H9N5O5S2","free base","N/A","OC1=NN=C(SC2=NC=C(S2)[N+]([O-])=O)[N]1C3=CC=C4OCCOC4=C3",2.738,5,1,4]
["S8202","PF-06447475","e8","L3000-34","in 10mM DMSO","LRRK2","Autophagy","PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.",305.33,"1527473-33-1",{"v":61,"d":"61.00"},199.78,"<1","N/A","http://selleckchem.com/products/pf-06447475.html","C17H15N5O","free base","N/A","N#CC1=CC=CC(=C1)C2=C[NH]C3=NC=NC(=C23)N4CCOCC4",{"v":2.33,"d":"2.330"},3,1,2]
["S8205","Enasidenib (AG-221)","f8","L3000-34","in 10mM DMSO","Dehydrogenase","Metabolism","Enasidenib (AG-221) is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme.",473.38,"1446502-11-9",{"v":94,"d":"94.00"},198.57,"<1","N/A","http://selleckchem.com/products/ag-221-enasidenib.html","C19H17F6N7O","free base","N/A","CC(C)(O)CNC1=NC(=NC(=N1)NC2=CC=NC(=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F",4.878,5,2,8]
["S8206","Ivosidenib (AG-120)","g8","L3000-34","in 10mM DMSO","Dehydrogenase","Metabolism","Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.",582.96,"1448347-49-6",{"v":100,"d":"100.00"},171.54,"<1","N/A","http://selleckchem.com/products/ag-120-Ivosidenib.html","C28H22ClF3N6O3","free base","N/A","FC1=CN=CC(=C1)N(C(C(=O)NC2CC(F)(F)C2)C3=C(Cl)C=CC=C3)C(=O)C4CCC(=O)N4C5=NC=CC(=C5)C#N",3.004,5,1,7]
["S8209","HLCL-61 HCL","h8","L3000-34","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.",380.91,"1158279-20-9",{"v":76,"d":"76.00"},199.52,"<1","N/A","http://selleckchem.com/products/hlcl-61-hydrochloride.html","C23H24N2O.HCl","hydrochloride","HLCL61","Cl.CC[N]1C2=CC=CC=C2C3=C1C=CC(=C3)CNCC4=C(OC)C=CC=C4",5.364,1,1,6]
["S8215","BAY 1217389","a9","L3000-34","in 10mM DMSO","MPS1","Cell Cycle","BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.",{"v":561.5,"d":"561.50"},"1554458-53-5",{"v":100,"d":"100.00"},178.09,"<1","N/A","http://selleckchem.com/products/bay-1217389.html","C27H24F5N5O3","free base","N/A","COC1=CC=C(OC2=N[N]3C(=CN=C3C(=C2)NCCC(F)(F)F)C4=CC(=C(C=C4)C(=O)NC5CC5)C)C(=C1F)F",5.255,5,2,10]
["S8218","PF-8380","b9","L3000-34","in 10mM DMSO","PDE","Metabolism","PF-8380 is a potent autotaxin (ATX) inhibitor with IC50 of 2.8 nM in an in vitro enzyme assay.",478.33,"1144035-53-9",{"v":95,"d":"95.00"},198.61,"<1","N/A","http://selleckchem.com/products/pf-8380.html","C22H21Cl2N3O5","free base","N/A","ClC1=CC(=CC(=C1)Cl)COC(=O)N2CCN(CC2)CCC(=O)C3=CC=C4NC(=O)OC4=C3",4.106,5,1,7]
["S8219","Bitopertin","c9","L3000-34","in 10mM DMSO","Amino acid transporter,GlyT","Neuronal Signaling","Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.",543.46,"845614-11-1",{"v":100,"d":"100.00"},184.01,"<1","N/A","http://selleckchem.com/products/bitopertin-rg1678-ro-4917838.html","C21H20F7N3O4S","free base","RG1678, RO-4917838","CC(OC1=CC=C(C=C1C(=O)N2CCN(CC2)C3=NC=C(C=C3F)C(F)(F)F)[S](C)(=O)=O)C(F)(F)F",4.304,5,0,7]
["S8228","NT157","d9","L3000-34","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.",412.26,"1384426-12-3",{"v":82,"d":"82.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/nt157.html","C16H14BrNO5S","free base","N/A","OC1=CC(=CC(=C1O)O)CNC(=S)/C=C/C2=CC(=C(O)C(=C2)Br)O",3.721,0,6,5]
["S8234","RS-1","e9","L3000-34","in 10mM DMSO","CRISPR/Cas9,RAD51","DNA Damage/DNA Repair","RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.",524.23,"312756-74-4",{"v":100,"d":"100.00"},190.76,"<1","N/A","http://selleckchem.com/products/rs-1.html","C20H16Br2N2O3S","free base","N/A","BrC1=CC=C(NC(=O)C2=CC=C(Br)C(=C2)[S](=O)(=O)NCC3=CC=CC=C3)C=C1",4.606,3,2,6]
["S8236","MK-886","f9","L3000-34","in 10mM DMSO","FLAP","Immunology & Inflammation","MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.",472.08,"118414-82-7",{"v":94,"d":"94.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-886-l-663-536.html","C27H34ClNO2S","free base","L-663,536","CC(C)C1=CC=C2[N](CC3=CC=C(Cl)C=C3)C(=C(SC(C)(C)C)C2=C1)CC(C)(C)C(O)=O",8.114,1,0,8]
["S8237","IC261","g9","L3000-34","in 10mM DMSO","Casein Kinase","Metabolism","IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.",311.33,"186611-52-9",{"v":62,"d":"62.00"},199.15,"<1","N/A","http://selleckchem.com/products/ic261.html","C18H17NO4","free base","SU-5607","COC1=CC(=C(\\C=C/2C(=O)NC3=C2C=CC=C3)C(=C1)OC)OC",2.681,4,1,4]
["S8238","SB366791","h9","L3000-34","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SB-366791 is a novel, potent, and selective, cinnamide TRPV1 antagonist with an IC50 of 5.7 nM.",287.74,"472981-92-3",{"v":57,"d":"57.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/sb366791.html","C16H14ClNO2","free base","N/A","COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(Cl)C=C2",{"v":3.73,"d":"3.730"},2,1,4]
["S8240","SMER28","a10","L3000-34","in 10mM DMSO","Autophagy","Autophagy","SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells.",264.12,"307538-42-7",{"v":52,"d":"52.00"},196.88,"<1","N/A","http://selleckchem.com/products/smer28.html","C11H10BrN3","free base","N/A","BrC1=CC=C2N=CN=C(NCC=C)C2=C1",3.101,2,1,3]
["S8241","Ponesimod","b10","L3000-34","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.",460.97,"854107-55-4",{"v":92,"d":"92.00"},199.58,"<1","N/A","http://selleckchem.com/products/ponesimod-act-128800.html","C23H25ClN2O4S","free base","ACT-128800","CCCN=C1S\\C(=C/C2=CC=C(OCC(O)CO)C(=C2)Cl)C(=O)N1C3=CC=CC=C3C",4.941,3,2,8]
["S8242","EAI045","c10","L3000-34","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but spares the wild-type receptor.",{"v":383.4,"d":"383.40"},"1942114-09-1",{"v":76,"d":"76.00"},198.23,"<1","N/A","http://selleckchem.com/products/eai045.html","C19H14FN3O3S","free base","N/A","OC1=CC=C(F)C=C1C(N2CC3=C(C=CC=C3)C2=O)C(=O)NC4=NC=CS4",2.313,3,2,4]
["S8244","Etomoxir sodium salt","d10","L3000-34","in 10mM DMSO","Apoptosis related,CPT,Transferase","Metabolism","Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.",320.74,"828934-41-4",{"v":64,"d":"64.00"},199.54,{"v":64,"d":"64.00"},199.54,"http://selleckchem.com/products/etomoxir-na-salt.html","C15H18ClO4.Na","sodium salt","(R)-(+)-Etomoxir sodium salt","[Na]OC(=O)C1(CCCCCCOC2=CC=C(Cl)C=C2)CO1",3.847,4,0,10]
["S8245","Thiomyristoyl","e10","L3000-34","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.",581.85,"1429749-41-6",{"v":100,"d":"100.00"},171.87,"<1","N/A","http://selleckchem.com/products/thiomyristoyl.html","C34H51N3O3S","free base","TM","CCCCCCCCCCCCCC(=S)NCCCCC(NC(=O)OCC1=CC=CC=C1)C(=O)NC2=CC=CC=C2",9.441,3,3,24]
["S8246","RK-33","f10","L3000-34","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis","Cell Cycle","RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.",428.44,"1070773-09-9",{"v":85,"d":"85.00"},198.39,"<1","N/A","http://selleckchem.com/products/rk-33.html","C23H20N6O3","free base","N/A","COC1=CC=C(C[N]2C=NC3=C2N=CN=C4N(CC5=CC=C(OC)C=C5)C(=O)N=C34)C=C1",2.687,7,0,6]
["S8248","IQ-1","g10","L3000-34","in 10mM DMSO","PP2A,Wnt/beta-catenin","Stem Cells & Wnt","IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.",362.42,"331001-62-8",{"v":72,"d":"72.00"},198.66,"<1","N/A","http://selleckchem.com/products/iq-1.html","C21H22N4O2","free base","N/A","CC(=O)C1=CC=C(C=C1)N=N\\C(C(N)=O)=C2\\NC(C)(C)CC3=C2C=CC=C3",3.005,4,2,4]
["S8249","HPI-4 (Ciliobrevin A)","h10","L3000-34","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","HPI-4 (Ciliobrevin A, Hedgehog Pathway Inhibitor 4) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.",358.18,"302803-72-1",{"v":71,"d":"71.00"},198.22,"<1","N/A","http://selleckchem.com/products/hpi-4-ciliobrevin-a.html","C17H9Cl2N3O2","free base","Hedgehog Pathway Inhibitor 4","ClC1=CC(=C(C=C1)C(=O)\\C(C#N)=C/2NC(=O)C3=C(N2)C=CC=C3)Cl",3.847,2,2,2]
["S8250","79-6 (CID5721353)","a11","L3000-34","in 10mM DMSO","Bcl-6","Apoptosis","79-6 (CID5721353) (BCL6 inhibitor) is a BCL6 inhibitor with Kd value of 138 μM.",457.28,"301356-95-6",{"v":91,"d":"91.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/79-6-cid5721353-bcl6-inhibitor.html","C15H9BrN2O6S2","free base","BCL6 inhibitor","OC(=O)CC(N1C(=S)S/C(C1=O)=C/2C(=O)NC3=CC=C(Br)C=C23)C(O)=O",2.057,4,1,4]
["S8251","Necrosulfonamide","b11","L3000-34","in 10mM DMSO","Mixed Lineage Kinase","MAPK","Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).",461.47,"1360614-48-7",{"v":92,"d":"92.00"},199.36,"<1","N/A","http://selleckchem.com/products/necrosulfonamide.html","C18H15N5O6S2","free base","N/A","COC1=C(N[S](=O)(=O)C2=CC=C(NC(=O)\\C=C\\C3=CC=C(S3)[N+]([O-])=O)C=C2)N=CC=N1",2.303,6,2,8]
["S8253","CCT245737","c11","L3000-34","in 10mM DMSO","Chk","Cell Cycle","CCT245737 (SRA737, PNT-737) is an orally active CHK1 inhibitor with The IC50 of 1.4 nM. It exhibits >1,000-fold selectivity against CHK2 and CDK1.",379.34,"1489389-18-5",{"v":75,"d":"75.00"},197.71,"<1","N/A","http://selleckchem.com/products/cct245737.html","C16H16F3N7O","free base","SRA737, PNT-737","FC(F)(F)C1=CN=C(NC2=CN=C(C=N2)C#N)C=C1NCC3CNCCO3",{"v":1.46,"d":"1.460"},4,3,6]
["S8261","GSK583","d11","L3000-34","in 10mM DMSO","Interleukins,RIP kinase,TNF-alpha","Apoptosis","GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.",398.45,"1346547-00-9",{"v":79,"d":"79.00"},198.27,"<1","N/A","http://selleckchem.com/products/gsk583.html","C20H19FN4O2S","free base","N/A","CC(C)(C)[S](=O)(=O)C1=CC=C2N=CC=C(NC3=N[NH]C4=C3C=C(F)C=C4)C2=C1",4.412,4,2,4]
["S8265","GSK6853","e11","L3000-34","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.",409.48,"1910124-24-1",{"v":81,"d":"81.00"},197.81,"<1","N/A","http://selleckchem.com/products/gsk6853.html","C22H27N5O3","free base","N/A","COC1=CC=CC=C1C(=O)NC2=CC3=C(C=C2N4CCNCC4C)N(C)C(=O)N3C",1.834,3,2,4]
["S8270","SRT2183","f11","L3000-34","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.",468.57,"1001908-89-9",{"v":93,"d":"93.00"},198.48,"<1","N/A","http://selleckchem.com/products/srt2183.html","C27H24N4O2S","free base","N/A","OC1CCN(C1)CC2=CSC3=NC(=C[N]23)C4=C(NC(=O)C5=CC6=C(C=CC=C6)C=C5)C=CC=C4",{"v":3.6,"d":"3.600"},2,2,5]
["S8272","XMD8-87","g11","L3000-34","in 10mM DMSO","ACK","Protein Tyrosine Kinase","XMD8-87 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations.",445.52,"1234480-46-6",{"v":65,"d":"65.00"},{"v":145.9,"d":"145.90"},"<1","N/A","http://selleckchem.com/products/xmd8-87.html","C24H27N7O2","free base","N/A","COC1=CC(=CC=C1NC2=NC3=C(NC(=O)C4=C(C=CC=C4)N3C)C=N2)N5CCN(C)CC5",3.475,4,2,4]
["S8273","XMD16-5","h11","L3000-34","in 10mM DMSO","ACK","Protein Tyrosine Kinase","XMD16-5 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 16 nmol/L and 77 nmol/L for the D163E and R806Q mutations.",416.48,"1345098-78-3",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/xmd16-5.html","C23H24N6O2","free base","N/A","CN1C2=C(C=CC=C2)C(=O)NC3=C1N=C(NC4=CC=C(C=C4)N5CCC(O)CC5)N=C3",2.967,3,3,3]
["S8275","Tomivosertib (eFT-508)","a2","L3000-35","in 10mM DMSO","eIF,MNK,PD-1/PD-L1","MAPK","Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.",340.38,"1849590-01-7",{"v":13,"d":"13.00"},38.19,"<1","N/A","http://selleckchem.com/products/eft-508.html","C17H20N6O2","free base","N/A","CC1=C2N(C(=O)C(=C1)NC3=NC=NC(=C3)N)C4(CCCCC4)NC2=O",0.717,4,3,2]
["S8276","FCCP","b2","L3000-35","in 10mM DMSO","ATPase,OXPHOS","Apoptosis","FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.",254.17,"370-86-5",{"v":50,"d":"50.00"},196.72,"<1","N/A","http://selleckchem.com/products/fccp.html","C10H5F3N4O","free base","Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone","FC(F)(F)OC1=CC=C(NN=C(C#N)C#N)C=C1",3.924,2,1,4]
["S8278","SHP099 HCl","c2","L3000-35","in 10mM DMSO","phosphatase","Metabolism","SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.",388.72,"2200214-93-1",{"v":77,"d":"77.00"},{"v":181.1,"d":"181.10"},{"v":2,"d":"2.00"},{"v":4.7,"d":"4.70"},"http://selleckchem.com/products/shp099-dihydrochloride.html","C16H20Cl3N5","Dihydrochloride","N/A","Cl.CC1(N)CCN(CC1)C2=CN=C(C(=N2)N)C3=CC=CC(=C3Cl)Cl",{"v":3.41,"d":"3.410"},2,2,2]
["S8279","(±)-Shikonin","d2","L3000-35","in 10mM DMSO","Anti-infection,Chloride Channel,COVID-19,NF-κB,PKM,Proteasome,TNF-alpha","Metabolism","(±)-Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.",{"v":288.3,"d":"288.30"},"54952-43-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/shikonin.html","C16H16O5","free base","Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["S8280","IMR-1","e2","L3000-35","in 10mM DMSO","Notch","Stem Cells & Wnt","IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.",353.41,"310456-65-6",{"v":70,"d":"70.00"},198.07,"<1","N/A","http://selleckchem.com/products/imr-1.html","C15H15NO5S2","free base","N/A","CCOC(=O)COC1=CC=C(C=C1OC)\\C=C2/SC(=S)NC2=O",2.864,5,1,7]
["S8281","CCF642","f2","L3000-35","in 10mM DMSO","PDI","ER stress & UPR","CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.",378.45,"346640-08-2",{"v":15,"d":"15.00"},39.64,"<1","N/A","http://selleckchem.com/products/ccf642.html","C15H10N2O4S3","free base","AC1LYELL","COC1=CC=C(C=C1)N2C(=S)S\\C(=C/C3=CC=C(S3)[N+]([O-])=O)C2=O",4.579,2,0,4]
["S8283","SQ22536","g2","L3000-35","in 10mM DMSO","cAMP","GPCR & G Protein","SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.",205.22,"17318-31-9",{"v":41,"d":"41.00"},199.79,{"v":41,"d":"41.00"},199.79,"http://selleckchem.com/products/sq22536.html","C9H11N5O","free base","9-(tetrahydrofuran-2-yl)-9h-purin-6-amine","NC1=C2N=C[N](C3CCCO3)C2=NC=N1",0.035,4,1,1]
["S8284","Fatostatin (125B11) HBr","h2","L3000-35","in 10mM DMSO","Fatty Acid Synthase,SREBP","Metabolism","Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.",375.33,"298197-04-3",{"v":7,"d":"7.00"},18.65,"<1","N/A","https://www.selleckchem.com/products/fatostatin-hbr.html","C18H18N2S.HBr","hydrobromide","Fatostatin A","Br.CCCC1=CC(=CC=N1)C2=NC(=CS2)C3=CC=C(C)C=C3",5.389,2,0,4]
["S8286","MKC-3946","a3","L3000-35","in 10mM DMSO","IRE1","ER stress & UPR","MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.",380.46,"1093119-54-0",{"v":38,"d":"38.00"},99.88,"<1","N/A","http://selleckchem.com/products/mkc-3946.html","C21H20N2O3S","free base","N/A","CN1CCN(CC1)C(=O)C2=CC=C(S2)C3=CC4=CC=C(O)C(=C4C=C3)C=O",{"v":3.39,"d":"3.390"},2,1,3]
["S8287","CPI-455 HCl","b3","L3000-35","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","CPI-455  HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.",314.77,"2095432-28-1",{"v":10,"d":"10.00"},31.77,"<1","N/A","https://www.selleckchem.com/products/cpi-455-hcl.html","C16H15ClN4O","hydrochloride","N/A","Cl.CC(C)C1=C(NC2=C(C=N[N]2C1=O)C#N)C3=CC=CC=C3",3.195,2,1,2]
["S8288","VLX1570","c3","L3000-35","in 10mM DMSO","DUB","Ubiquitin","VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.",469.39,"1431280-51-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://selleckchem.com/products/vlx1570.html","C23H17F2N3O6","free base","N/A","[O-][N+](=O)C1=C(F)C=CC(=C1)\\C=C2/CCN(C\\C(=C/C3=CC=C(F)C(=C3)[N+]([O-])=O)C2=O)C(=O)C=C",4.385,2,0,5]
["S8289","NQDI-1","d3","L3000-35","in 10mM DMSO","ASK","Apoptosis","NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.",319.31,"175026-96-7",{"v":21,"d":"21.00"},65.77,"<1","N/A","http://selleckchem.com/products/nqdi-1.html","C19H13NO4","free base","N/A","CCOC(=O)C1=C2C3=C(C=CC=C3)C(=O)C4=C2C(=CC=C4)NC1=O",2.469,4,1,3]
["S8291","Atractylenolide I","e3","L3000-35","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.",{"v":230.3,"d":"230.30"},"73069-13-3",{"v":46,"d":"46.00"},199.74,"<1","N/A","http://selleckchem.com/products/atractylenolide-i.html","C15H18O2","free base","N/A","CC1=C2CC3C(=C)CCCC3(C)C=C2OC1=O",3.323,2,0,0]
["S8292","Selonsertib (GS-4997)","f3","L3000-35","in 10mM DMSO","ASK","Apoptosis","Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.",445.49,"1448428-04-3",{"v":36,"d":"36.00"},80.81,"<1","N/A","http://selleckchem.com/products/selonsertib-gs-4997.html","C24H24FN7O","free base","N/A","CC(C)[N]1C=NN=C1C2=CC=CC(=N2)NC(=O)C3=CC(=C(C)C=C3F)[N]4C=NC(=C4)C5CC5",4.054,5,1,6]
["S8294","Olmutinib (BI 1482694)","g3","L3000-35","in 10mM DMSO","BTK,EGFR","Protein Tyrosine Kinase","Olmutinib (BI 1482694) is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of Bruton's tyrosine kinase.",486.59,"1353550-13-6",{"v":97,"d":"97.00"},199.35,"<1","N/A","http://selleckchem.com/products/olmutinib-hm61713-bi-1482694.html","C26H26N6O2S","free base","HM61713","CN1CCN(CC1)C2=CC=C(NC3=NC(=C4SC=CC4=N3)OC5=CC=CC(=C5)NC(=O)C=C)C=C2",5.449,4,2,7]
["S8296","dBET1","h3","L3000-35","in 10mM DMSO","Epigenetic Reader Domain,PROTAC","Epigenetics","dBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment.",785.27,"1799711-21-9",{"v":100,"d":"100.00"},127.34,"<1","N/A","http://www.selleck.cn/products/bet1.html","C38H37ClN8O7S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C6CCC(=O)NC6=O)C5=O)N=C2C7=CC=C(Cl)C=C7)C",2.976,10,3,12]
["S8298","CZ415","a4","L3000-35","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.",459.56,"1429639-50-8",{"v":91,"d":"91.00"},198.02,"<1","N/A","http://selleckchem.com/products/cz415.html","C22H29N5O4S","free base","N/A","CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C[S](=O)(=O)C3(C)C)C(=N2)N4CCOCC4C",{"v":2.2,"d":"2.200"},6,2,4]
["S8299","HA15","b4","L3000-35","in 10mM DMSO","HSP (HSP90)","ER stress & UPR","HA15 is a molecule that targets specifically HSPA5 (Heat shock 70kDa protein 5) also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.",466.58,"1609402-14-3",{"v":93,"d":"93.00"},199.32,"<1","N/A","http://selleckchem.com/products/ha15.html","C23H22N4O3S2","free base","N/A","CN(C)C1=CC=CC2=C1C=CC=C2[S](=O)(=O)NC3=CC(=CC=C3)C4=CSC(=N4)NC(C)=O",3.452,4,2,6]
["S8301","Ossirene","c4","L3000-35","in 10mM DMSO","Immunology & Inflammation related,Interleukins","Immunology & Inflammation","AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.",312.05,"106566-58-9",{"v":62,"d":"62.00"},198.69,"<1","N/A","http://selleckchem.com/products/as101.html","C2H4Cl3O2Te.H4N","Coordination Co","AS101","[NH4+].Cl[Te-]1(Cl)(Cl)OCCO1",-0.379,2,0,0]
["S8302","SR-12813","d4","L3000-35","in 10mM DMSO","HMG-CoA Reductase","Metabolism","SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.",504.53,"126411-39-0",{"v":100,"d":"100.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/sr-12813.html","C24H42O7P2","free base","N/A","CCO[P](=O)(OCC)C(=CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)[P](=O)(OCC)OCC",4.891,4,1,13]
["S8303","Kobe0065","e4","L3000-35","in 10mM DMSO","Ras","Cell Cycle","Kobe0065 is an H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.",449.79,"436133-68-5",{"v":89,"d":"89.00"},197.87,"<1","N/A","http://selleckchem.com/products/kobe0065.html","C15H11ClF3N5O4S","free base","N/A","CC1=C(Cl)C=C(NC(=S)NNC2=C(C=C(C=C2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)C=C1",5.921,0,3,8]
["S8305","TRC051384","f4","L3000-35","in 10mM DMSO","HSP (HSP90)","Metabolism","TRC051384 is an inducer of heat shock protein 70 (HSP70) and potent anti-inflammatory agent.",465.54,"867164-40-7",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/trc051384.html","C25H31N5O4","free base","N/A","O=C(NCCN1CCOCC1)NC2=CC=C(C=C2)C(=O)\\C=C\\C3=CC=CC(=N3)N4CCOCC4",2.311,5,2,8]
["S8306","Leukadherin-1","g4","L3000-35","in 10mM DMSO","Complement System,Integrin","Cytoskeletal Signaling","Leukadherin-1 (LA1) is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1(an agonist for the complement receptor 3 (CD11b/CD18)).",421.49,"344897-95-6",{"v":15,"d":"15.00"},35.59,"<1","N/A","http://selleckchem.com/products/leukadherin-1.html","C22H15NO4S2","free base","N/A","OC(=O)C1=CC=C(C=C1)C2=CC=C(O2)/C=C/3SC(=S)N(CC4=CC=CC=C4)C3=O",5.465,3,0,5]
["S8309","ATI-2341","h4","L3000-35","in 10mM DMSO","CXCR","GPCR & G Protein","ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.",2256.82,"1337878-62-2",{"v":100,"d":"100.00"},44.31,"<1","N/A","http://selleckchem.com/products/ati-2341.html","C104H178N26O25S2","free base","N/A","CCCCCCCCCCCCCCCC(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=C(O)C=C2)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O",-5.119,19,28,89]
["S8312","NSC228155","a5","L3000-35","in 10mM DMSO","EGFR","Angiogenesis","NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.",290.25,"113104-25-9",{"v":15,"d":"15.00"},51.68,"<1","N/A","http://selleckchem.com/products/nsc228155.html","C11H6N4O4S","free base","N/A","[O-][N+](=O)C1=CC=C(SC2=CC=CC=[N+]2[O-])C3=NON=C13",1.957,3,0,3]
["S8314","5-Iodotubercidin","b5","L3000-35","in 10mM DMSO","Adenosine Kinase","Neuronal Signaling","5-Iodotubercidin (NSC 113939, 5-ITu) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.",392.15,"24386-93-4",{"v":78,"d":"78.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/5-iodotubercidin.html","C11H13IN4O4","free base","NSC 113939, 5-ITu","NC1=NC=NC2=C1C(=C[N]2C3OC(CO)C(O)C3O)I",-0.525,3,4,2]
["S8317","3BDO","c5","L3000-35","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.",327.33,"890405-51-3",{"v":65,"d":"65.00"},198.58,"<1","N/A","http://selleckchem.com/products/3bdo.html","C18H17NO5","free base","3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one","[O-][N+](=O)C1=C(OCC2CC(CC3=CC=CC=C3)C(=O)O2)C=CC=C1",3.782,3,0,6]
["S8318","Alantolactone","d5","L3000-35","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Alantolactone (helenin, helenine, Eupatal), a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction.",232.32,"546-43-0",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/alantolactone.html","C15H20O2","free base","helenin, helenine, Eupatal","CC1CCCC2(C)CC3OC(=O)C(=C)C3C=C12",3.311,2,0,0]
["S8319","7,8-Dihydroxyflavone","e5","L3000-35","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","7,8-Dihydroxyflavone (7,8-DHF) acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).",254.24,"38183-03-8",{"v":50,"d":"50.00"},196.66,"<1","N/A","http://selleckchem.com/products/7-8-dihydroxyflavone.html","C15H10O4","free base","7,8-DHF","OC1=CC=C2C(=O)C=C(OC2=C1O)C3=CC=CC=C3",2.652,2,2,1]
["S8320","SKL2001","f5","L3000-35","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.",286.29,"909089-13-0",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/skl2001.html","C14H14N4O3","free base","N/A","O=C(NCCC[N]1C=CN=C1)C2=NOC(=C2)C3=CC=CO3",0.929,5,1,6]
["S8322","Samotolisib (LY3023414)","g5","L3000-35","in 10mM DMSO","DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.",406.48,"1386874-06-1",{"v":47,"d":"47.00"},115.63,"<1","N/A","http://selleckchem.com/products/ly3023414.html","C23H26N4O3","free base","GTPL8918","COC(C)CN1C(=O)N(C)C2=C1C3=CC(=CC=C3N=C2)C4=CC(=CN=C4)C(C)(C)O",1.883,4,0,5]
["S8323","ITSA-1 (ITSA1)","h5","L3000-35","in 10mM DMSO","HDAC","Epigenetics","ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors.",292.12,"200626-61-5",{"v":58,"d":"58.00"},198.55,"<1","N/A","http://selleckchem.com/products/itsa-1-itsa1.html","C13H7Cl2N3O","free base","N/A","ClC1=CC=C(C(=C1)Cl)C(=O)[N]2N=NC3=CC=CC=C23",4.418,3,0,1]
["S8324","ZK756326 2HCl","a6","L3000-35","in 10mM DMSO","CCR","Microbiology","ZK756326 is a full agonist of CCR8（Chemokine receptor 8） with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.",429.38,"874911-96-3",{"v":39,"d":"39.00"},90.83,{"v":78,"d":"78.00"},181.66,"http://selleckchem.com/products/zk756326.html","C21H28N2O3.2HCl","Dihydrochloride","N/A","Cl.Cl.OCCOCCN1CCN(CC1)CC2=CC(=CC=C2)OC3=CC=CC=C3",3.514,2,1,9]
["S8326","Saccharin 1-methylimidazole (SMI)","b6","L3000-35","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.",265.29,"482333-74-4",{"v":53,"d":"53.00"},199.78,{"v":53,"d":"53.00"},199.78,"http://selleckchem.com/products/saccharin-1-methylimidazole-smi.html","C7H5NO3S.C4H6N2","free base","N/A","C[NH+]1C=CN=C1.[O-]C2=N[S](=O)(=O)C3=CC=CC=C23",-1.429,4,0,0]
["S8327","KYA1797K","c6","L3000-35","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).",442.51,"1956356-56-1",{"v":29,"d":"29.00"},65.54,{"v":29,"d":"29.00"},65.54,"http://selleckchem.com/products/kya1797k.html","C17H11N2O6S2.K","potassium salt","N/A","[O-][N+](=O)C1=CC=C(C=C1)C2=CC=C(O2)\\C=C3/SC(=S)N(CCC(=O)O[K])C3=O",3.967,4,0,7]
["S8329","CeMMEC13","d6","L3000-35","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).",336.34,"1790895-25-8",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cemmec13.html","C19H16N2O4","free base","N/A","CN1C(=O)C=C(C(=O)NC2=CC3=C(OCCO3)C=C2)C4=CC=CC=C14",1.989,4,1,2]
["S8330","Eganelisib (IPI-549)","e6","L3000-35","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Eganelisib (IPI-549) is a potent inhibitor of PI3K-γ with >100-fold selectivity over other lipid and protein kinases. The biochemical IC50 for PI3K-γ is 16 nM.",528.56,"1693758-51-8",{"v":100,"d":"100.00"},189.19,"<1","N/A","http://selleckchem.com/products/ipi-549.html","C30H24N8O2","free base","N/A","CC(NC(=O)C1=C2N=CC=C[N]2N=C1N)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)C#CC6=C[N](C)N=C6",2.732,5,2,6]
["S8334","XMU-MP-1","f6","L3000-35","in 10mM DMSO","MST","Hippo","XMU-MP-1 is an inhibitor of MST1/2 with IC50 values of 71.1±12.9 nM and 38.1±6.9 nM against MST1 and MST2, respectively.",416.48,"2061980-01-4",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/xmu-mp-1.html","C17H16N6O3S2","free base","N/A","CN1C(=O)C2=C(C=CS2)N(C)C3=NC(=NC=C13)NC4=CC=C(C=C4)[S](N)(=O)=O",2.236,5,2,3]
["S8335","PF-06409577","g6","L3000-35","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.",341.79,"1467057-23-3",{"v":68,"d":"68.00"},198.95,"<1","N/A","http://selleckchem.com/products/pf-06409577.html","C19H16ClNO3","free base","N/A","OC(=O)C1=C[NH]C2=CC(=C(C=C12)C3=CC=C(C=C3)C4(O)CCC4)Cl",4.133,1,1,3]
["S8337","1400W 2HCl","h6","L3000-35","in 10mM DMSO","NOS","Immunology & Inflammation","1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS).",250.17,"214358-33-5",{"v":35,"d":"35.00"},{"v":139.9,"d":"139.90"},{"v":35,"d":"35.00"},{"v":139.9,"d":"139.90"},"http://selleckchem.com/products/1400w.html","C10H15N3.2HCl","dihydrochloride","N-(3-(Aminomethyl)benzyl)acetamidine","Cl.Cl.CC(=N)NCC1=CC=CC(=C1)CN",0.881,0,2,4]
["S8339","Miransertib (ARQ 092) HCl","a7","L3000-35","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.",468.98,"1313883-00-9",{"v":75,"d":"75.00"},159.92,"<1","N/A","http://selleckchem.com/products/arq-092.html","C27H25ClN6","hydrochloride","Miransertib","Cl.NC1=NC=CC=C1C2=NC3=CC=C(N=C3[N]2C4=CC=C(C=C4)C5(N)CCC5)C6=CC=CC=C6",{"v":4.98,"d":"4.980"},3,2,4]
["S8340","SGC2085","b7","L3000-35","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.",312.41,"1821908-48-8",{"v":62,"d":"62.00"},198.46,"<1","N/A","http://selleckchem.com/products/sgc2085.html","C19H24N2O2","free base","N/A","CC(N)C(=O)NCC1=CC=C(OC2=CC(=CC(=C2)C)C)C(=C1)C",3.498,2,2,5]
["S8352","PT2385","c7","L3000-35","in 10mM DMSO","HIF","Epigenetics","PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.",383.34,"1672665-49-4",{"v":77,"d":"77.00"},200.87,"<1","N/A","http://www.selleckchem.com/products/pt2385.html","C17H12F3NO4S","Free Base","N/A","C[S](=O)(=O)C1=CC=C(OC2=CC(=CC(=C2)F)C#N)C3=C1C(O)C(F)(F)C3",2.732,3,1,3]
["S8353","Lirametostat (CPI-1205)","d7","L3000-35","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.",518.57,"1621862-70-1",{"v":100,"d":"100.00"},192.84,"<1","N/A","http://selleckchem.com/products/cpi-1205.html","C27H33F3N4O3","free base","CPI 1205, CPI1205","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCN(CC3)CC(F)(F)F)C4=C2C=CC=C4)C(=O)NC(=C1)C",3.348,3,2,8]
["S8355","APS-2-79 HCl","e7","L3000-35","in 10mM DMSO","MEK","MAPK","APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. IC50=120 ± 23 nM.",423.89,"2002381-31-7",{"v":97,"d":"97.00"},228.83,"<1","N/A","http://selleckchem.com/products/aps-2-79.html","C23H21N3O3.HCl","hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=C(OC4=CC=CC=C4)C=C3C",5.873,5,1,6]
["S8358","WNK463","f7","L3000-35","in 10mM DMSO","Serine/threonin kinase","Apoptosis","WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4) with IC50 of 5nM, 1nM, 6nM, and 9nM.",463.46,"2012607-27-9",{"v":92,"d":"92.00"},198.51,"<1","N/A","http://selleckchem.com/products/wnk463.html","C21H24F3N7O2","free base","N/A","CC(C)(C)NC(=O)C1=CN=C[N]1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F",2.173,6,1,6]
["S8359","UNC3866","g7","L3000-35","in 10mM DMSO","Histone Methyltransferase","Epigenetics","UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains.",795.02,"1872382-47-2",{"v":100,"d":"100.00"},125.78,"<1","N/A","http://selleckchem.com/products/unc3866.html","C43H66N6O8","free base","N/A","CCN(CC)CCCCC(NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C(=O)NC(CO)C(=O)OC",4.291,7,6,25]
["S8362","Tucatinib","h7","L3000-35","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Tucatinib (Irbinitinib, ONT-380, ARRY-380) is an oral, potent, selective, reversible and ATP-competitive small-molecule inhibitor of ErbB-2 (also called HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively in cell-based assays, showing ~500-fold selective for HER2 vs EGFR. It has potential antineoplastic activity.",480.52,"937263-43-9",{"v":96,"d":"96.00"},199.78,"<1","N/A","http://selleckchem.com/products/arry-380-ont-380.html","C26H24N8O2","free base","Irbinitinib, ONT-380, ARRY-380","CC1=CC(=CC=C1OC2=CC3=NC=N[N]3C=C2)NC4=NC=NC5=CC=C(NC6=NC(C)(C)CO6)C=C45",4.744,7,2,6]
["S8363","NMS-P118","a8","L3000-35","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).",395.42,"1262417-51-5",{"v":24,"d":"24.00"},60.69,"<1","N/A","http://selleckchem.com/products/nms-p118.html","C20H24F3N3O2","free base","N/A","NC(=O)C1=CC(=CC2=C1C(=O)N(C2)C3CCN(CC3)C4CCC(F)(F)CC4)F",1.422,2,1,3]
["S8365","Apoptozole","b8","L3000-35","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.",625.56,"1054543-47-3",{"v":100,"d":"100.00"},159.86,"<1","N/A","http://selleckchem.com/products/apoptozole.html","C33H25F6N3O3","free base","Apoptosis Activator VII","COC1=CC=C(C=C1)C2=C([N](CC3=CC=C(C=C3)C(N)=O)C(=N2)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=CC=C(OC)C=C5",8.042,4,1,10]
["S8366","CRT0066101 dihydrochloride","c8","L3000-35","in 10mM DMSO","PKD","GPCR & G Protein","CRT0066101 dihydrochloride is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.",411.33,"1883545-60-5",{"v":25,"d":"25.00"},60.78,{"v":82,"d":"82.00"},199.35,"https://www.selleckchem.com/products/crt0066101-dihydrochloride.html","C18H22N6O.2HCl","dihydrochloride","CRT0066101 2HCl","Cl.Cl.CCC(N)CNC1=NC(=NC=C1)C2=C(O)C=CC(=C2)C3=C[N](C)N=C3",2.781,3,3,6]
["S8368","LM10","d8","L3000-35","in 10mM DMSO","IDO/TDO","Metabolism","LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50 values of 0.62 and 2 μM for human and mouse TDO, respectively.",229.21,"1316695-35-8",{"v":45,"d":"45.00"},196.33,"<1","N/A","http://selleckchem.com/products/lm10.html","C11H8FN5","free base","N/A","FC1=CC=C2C(=C1)[NH]C=C2\\C=C\\C3=NN=N[NH]3",1.826,3,2,2]
["S8369","Lys05","e8","L3000-35","in 10mM DMSO","Autophagy","Autophagy","Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.",549.75,"1391426-24-6",{"v":9,"d":"9.00"},16.37,{"v":3,"d":"3.00"},5.46,"http://selleckchem.com/products/lys05.html","C23H23Cl2N5.3HCl","Trihydrochloride","N/A","Cl.Cl.Cl.CN(CCNC1=CC=NC2=C1C=CC(=C2)Cl)CCNC3=C4C=CC(=CC4=NC=C3)Cl",6.082,2,2,8]
["S8370","BGP-15 2HCl","f8","L3000-35","in 10mM DMSO","PARP","DNA Damage/DNA Repair","BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.",351.27,"66611-37-8",{"v":70,"d":"70.00"},199.28,{"v":70,"d":"70.00"},199.28,"http://selleckchem.com/products/bgp-15.html","C14H22N4O2.2HCl","dihydrochloride","N/A","Cl.Cl.NC(=N\\OCC(O)CN1CCCCC1)/C2=CC=CN=C2",1.097,3,2,6]
["S8372","AZD9496","g8","L3000-35","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.",442.47,"1639042-08-2",{"v":88,"d":"88.00"},198.88,"<1","N/A","http://selleckchem.com/products/azd9496.html","C25H25F3N2O2","free base","N/A","CC1CC2=C([NH]C3=CC=CC=C23)C(N1CC(C)(C)F)C4=C(F)C=C(\\C=C\\C(O)=O)C=C4F",2.903,1,1,5]
["S8379","YU238259","h8","L3000-35","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.",459.95,"1943733-16-1",{"v":91,"d":"91.00"},197.85,"<1","N/A","http://selleckchem.com/products/yu238259.html","C22H22ClN3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=CC=C(Cl)C=N3",3.076,5,2,9]
["S8382","ML390","a9","L3000-35","in 10mM DMSO","Dehydrogenase","Metabolism","ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.",{"v":406.4,"d":"406.40"},"2029049-79-2",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/ml390.html","C21H21F3N2O3","free base","N/A","FC(F)(F)OC1=CC=C(C=C1)C(=O)NCCC(=O)NC2CCCC3=C2C=CC=C3",5.065,3,2,7]
["S8387","MSC2530818","b9","L3000-35","in 10mM DMSO","CDK","Cell Cycle","MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.",340.81,"1883423-59-3",{"v":68,"d":"68.00"},199.52,"<1","N/A","http://selleckchem.com/products/msc2530818.html","C18H17ClN4O","free base","N/A","CC1=N[NH]C2=C1C=C(C=N2)C(=O)N3CCCC3C4=CC=C(Cl)C=C4",2.956,3,1,2]
["S8388","ML-7 HCl","c9","L3000-35","in 10mM DMSO","MLCK,PKA,PKC","Cytoskeletal Signaling","ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. ML-7 also inhibits PKA and PKC with Ki of 21 μM and 42 μM, respectively.",452.74,"110448-33-4",{"v":90,"d":"90.00"},198.79,"<1","N/A","http://selleckchem.com/products/ml-7.html","C15H17IN2O2S.HCl","hydrochloride","N/A","Cl.IC1=C2C=CC=C(C2=CC=C1)[S](=O)(=O)N3CCCNCC3",2.299,2,1,2]
["S8390","LXR-623 (WAY-252623)","d9","L3000-35","in 10mM DMSO","Liver X Receptor","Metabolism","LXR-623 (WAY-252623) is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.",422.78,"875787-07-8",{"v":84,"d":"84.00"},198.68,"<1","N/A","http://selleckchem.com/products/lxr-623-way-252623.html","C21H12ClF5N2","free base","N/A","FC1=CC=C(C=C1)C2=C3C=CC=C(C3=N[N]2CC4=CC=C(F)C=C4Cl)C(F)(F)F",7.227,1,0,4]
["S8397","Eltanexor (KPT-8602)","e9","L3000-35","in 10mM DMSO","CRM1","Transmembrane Transporters","Eltanexor (KPT-8602, ONO-7706，ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.",428.29,"1642300-52-4",{"v":85,"d":"85.00"},198.46,"<1","N/A","http://selleckchem.com/products/kpt-8602.html","C17H10F6N6O","free base","ONO-7706，ATG-016","NC(=O)/C(=C/[N]1C=NC(=N1)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3=CN=CN=C3",2.002,5,1,6]
["S8400","Mivebresib (ABBV-075)","f9","L3000-35","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain","Epigenetics","Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.",459.47,"1445993-26-9",{"v":91,"d":"91.00"},198.05,"<1","N/A","http://selleckchem.com/products/mivebresib-abbv-075.html","C22H19F2N3O4S","free base","N/A","CC[S](=O)(=O)NC1=CC(=C(OC2=C(F)C=C(F)C=C2)C=C1)C3=CN(C)C(=O)C4=C3C=C[NH]4",3.027,4,2,6]
["S8401","Erdafitinib (JNJ-42756493)","g9","L3000-35","in 10mM DMSO","Apoptosis related,c-Kit,c-RET,CSF-1R,FGFR,PDGFR,VEGFR","Angiogenesis","Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Erdafitinib also binds to RET (c-RET), CSF-1R, PDGFR-α/PDGFR-β, FLT4, Kit (c-Kit) and VEGFR-2 and induces cellular apoptosis.",446.54,"1346242-81-6",{"v":89,"d":"89.00"},199.31,"<1","N/A","http://selleckchem.com/products/jnj-42756493-erdafitinib.html","C25H30N6O2","free base","N/A","COC1=CC(=CC(=C1)N(CCNC(C)C)C2=CC3=NC(=CN=C3C=C2)C4=C[N](C)N=C4)OC",3.943,5,1,9]
["S8402","KRIBB11","h9","L3000-35","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","KRIBB11 abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. It is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1). KRIBB11 induces growth arrest and apoptosis.",284.27,"342639-96-7",{"v":3,"d":"3.00"},10.55,"<1","N/A","http://selleckchem.com/products/kribb11.html","C13H12N6O2","free base","N/A","CNC1=CC=C(C(=N1)NC2=CC=C3[NH]N=CC3=C2)[N+]([O-])=O",2.654,2,3,4]
["S8403","MX69","a10","L3000-35","in 10mM DMSO","MDM2/MDMX","Apoptosis","MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment.",474.57,"1005264-47-0",{"v":95,"d":"95.00"},200.18,"<1","N/A","http://selleckchem.com/products/mx69.html","C27H26N2O4S","free base","N/A","CC1=C(C)C=C(N[S](=O)(=O)C2=CC3=C(NC(C4CC=CC34)C5=CC=C(C=C5)C(O)=O)C=C2)C=C1",5.082,3,2,5]
["S8404","S49076","b10","L3000-35","in 10mM DMSO","Axl,c-Met,FGFR,Mertk","Protein Tyrosine Kinase","S49076 is a novel, potent inhibitor of Met (c-Met), AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L.",{"v":438.5,"d":"438.50"},"1265965-22-7",{"v":87,"d":"87.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/s49076.html","C22H22N4O4S","free base","N/A","O=C1CSC(=O)N1CC2=CC=C3NC(=O)C(=C\\C4=CC(=C[NH]4)CN5CCOCC5)/C3=C2",1.882,4,2,5]
["S8405","RRx-001","c10","L3000-35","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. RRx-001 triggers apoptosis and exhibits anticancer activity.",268.02,"925206-65-1",{"v":53,"d":"53.00"},197.75,"<1","N/A","http://selleckchem.com/products/rrx-001.html","C5H6BrN3O5","free base","N/A","[O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O",0.473,1,0,3]
["S8412","Naquotinib(ASP8273)","d10","L3000-35","in 10mM DMSO","EGFR","Angiogenesis","Naquotinib (ASP8273) is an orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.",562.71,"1448232-80-1",{"v":52,"d":"52.00"},92.41,"<1","N/A","http://selleckchem.com/products/naquotinib-asp8273.html","C30H42N8O3","free base","N/A","CCC1=NC(=C(NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(C)CC4)N=C1OC5CCN(C5)C(=O)C=C)C(N)=O",2.756,5,2,9]
["S8419","Stenoparib (E7449)","e10","L3000-35","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.",317.34,"1140964-99-3",{"v":4,"d":"4.00"},{"v":12.6,"d":"12.60"},"<1","N/A","http://selleckchem.com/products/e7449.html","C18H15N5O","free base","2X-121, MGI25036","O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5",1.436,3,2,2]
["S8420","R-IMPP","f10","L3000-35","in 10mM DMSO","PCSK9","Metabolism","R-IMPP is an inhibitor of PCSK9 secretion, half maximal inhibitory concentration [IC50] = 4.8 μM.",389.49,"2133832-83-2",{"v":77,"d":"77.00"},197.69,{"v":7,"d":"7.00"},17.97,"http://selleckchem.com/products/r-impp.html","C24H27N3O2","free base","N/A","COC1=CC=C(CCC(=O)N(C2CCCNC2)C3=C4C=CC=CC4=CC=N3)C=C1",3.684,3,1,6]
["S8426","10074-G5","g10","L3000-35","in 10mM DMSO","Myc","Cell Cycle","10074-G5 is a c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 µM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC50 = 146 µM).",332.31,"413611-93-5",{"v":60,"d":"60.00"},180.55,"<1","N/A","http://selleckchem.com/products/10074-g5.html","C18H12N4O3","free base","N/A","[O-][N+](=O)C1=CC=C(NC2=C(C=CC=C2)C3=CC=CC=C3)C4=NON=C14",4.362,3,1,4]
["S8427","LTURM34","h10","L3000-35","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM.",414.48,"1879887-96-3",{"v":82,"d":"82.00"},197.84,"<1","N/A","http://selleckchem.com/products/lturm34.html","C24H18N2O3S","free base","N/A","O=C1N=C(OC2=C1C=CC=C2C3=C4SC5=C(C=CC=C5)C4=CC=C3)N6CCOCC6",4.946,4,0,2]
["S8429","PNU-74654","a11","L3000-35","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4.",320.34,"113906-27-7",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/pnu-74654.html","C19H16N2O3","free base","N/A","CC1=CC=C(O1)/C=N/NC(=O)C2=CC=CC=C2OC3=CC=CC=C3",3.784,4,1,5]
["S8432","Troglitazone (CS-045)","b11","L3000-35","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,PPAR","Metabolism","Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced ferroptosis and lipid peroxidation in Pfa1 cells.",441.54,"97322-87-7",{"v":88,"d":"88.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/troglitazone-cs-045.html","C24H27NO5S","free base","Rezulin, Romglizone, Prelay, Romozin","CC1=C(O)C(=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C)C",5.682,4,2,5]
["S8433","NS-398 (NS398)","c11","L3000-35","in 10mM DMSO","COX","Neuronal Signaling","NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.",314.36,"123653-11-2",{"v":62,"d":"62.00"},197.23,"<1","N/A","http://selleckchem.com/products/ns-398-ns398.html","C13H18N2O5S","free base","N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide","C[S](=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O",2.477,3,1,5]
["S8434","B02","d11","L3000-35","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).",339.39,"1290541-46-6",{"v":67,"d":"67.00"},197.41,"<1","N/A","http://selleckchem.com/products/b02.html","C22H17N3O","free base","N/A","O=C1N(CC2=CC=CC=C2)C(=NC3=C1C=CC=C3)/C=C/C4=CC=CN=C4",{"v":3.6,"d":"3.600"},3,0,4]
["S8438","T-3775440 HCl","e11","L3000-35","in 10mM DMSO","Histone Demethylase,LSD1","Methylation","T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.",346.85,"1422535-52-1",{"v":69,"d":"69.00"},198.93,{"v":22,"d":"22.00"},63.43,"http://www.selleck.cn/products/t-3775440-hcl.html","C18H23ClN4O","HCl","N/A","Cl.C[N]1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4",2.262,2,2,6]
["S8439","Monastrol","f11","L3000-35","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) with an IC50 of 14μM, which is essential for maintaining separation of the half-spindles.",292.35,"329689-23-8",{"v":58,"d":"58.00"},198.39,"<1","N/A","http://selleckchem.com/products/monastrol.html","C14H16N2O3S","free base","(±)-Monastrol","CCOC(=O)C1=C(C)NC(=S)NC1C2=CC(=CC=C2)O",2.459,2,3,4]
["S8441","LW 6","g11","L3000-35","in 10mM DMSO","HIF","Angiogenesis","LW 6 (CAY10585, AC1-001) is a hypoxia-inducible factor 1(HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. LW6 inhibits HIF and MDH2 expression with IC50 values of 4.4 and 6.3 μM, respectively.",435.51,"934593-90-5",{"v":13,"d":"13.00"},29.85,"<1","N/A","http://selleckchem.com/products/lw-6.html","C26H29NO5","free base","CAY10585, AC1-001","COC(=O)C1=CC(=C(O)C=C1)NC(=O)COC2=CC=C(C=C2)[C]34CC5[CH2][CH](C[CH]([CH2]5)C3)C4",4.472,4,2,7]
["S8443","MK-8617","h11","L3000-35","in 10mM DMSO","HIF","Angiogenesis","MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.",443.45,"1187990-87-9",{"v":20,"d":"20.00"},{"v":45.1,"d":"45.10"},"<1","N/A","http://selleckchem.com/products/mk-8617.html","C24H21N5O4","free base","N/A","COC1=CC=C(C=C1)C(NC(=O)C2=C(O)N=C(N=C2)C3=NN=CC=C3)C4=CC=C(OC)C=C4",3.149,7,2,7]
["S8444","KPT 9274 ( ATG-019)","a2","L3000-36","in 10mM DMSO","NAMPT,PAK","Metabolism","KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.",610.62,"1643913-93-2",{"v":100,"d":"100.00"},163.77,"<1","N/A","http://selleckchem.com/products/kpt-9274.html","C35H29F3N4O3","free base","N/A","NC1=NC=C(C=C1)\\C=C\\C(=O)NCC2=CC3=C(O2)C(=CC(=C3)C4=CC=C(C=C4)C(=O)N5CCC(F)(F)CC5)C6=CC=C(F)C=C6",{"v":5.59,"d":"5.590"},4,2,7]
["S8446","Importazole","b2","L3000-36","in 10mM DMSO","Apoptosis related","Apoptosis","Importazole is a small molecule inhibitor of the transport receptor importin-β (Karyopherin beta) specifically blocking importin-β-mediated nuclear import. Importazole induces apoptosis and inhibits tumor growth.",318.42,"662163-81-7",{"v":63,"d":"63.00"},197.85,"<1","N/A","http://selleckchem.com/products/importazole.html","C20H22N4","free base","N/A","CC(NC1=NC(=NC2=CC=CC=C12)N3CCCC3)C4=CC=CC=C4",4.841,2,1,4]
["S8448","ZINC00881524 (ROCK inhibitor)","c2","L3000-36","in 10mM DMSO","ROCK","Cell Cycle","ZINC00881524 is a ROCK inhibitor.",380.46,"557782-81-7",{"v":76,"d":"76.00"},199.76,"<1","N/A","http://selleckchem.com/products/zinc00881524-rock-inhibitor.html","C21H20N2O3S","free base","N/A","COC1=C(OC)C=C(CC(=O)NC2=NC3=C(CCC4=CC=CC=C34)S2)C=C1",4.031,4,1,5]
["S8452","BAY-876","d2","L3000-36","in 10mM DMSO","GLUT","Metabolism","BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4.",496.42,"1799753-84-6",{"v":99,"d":"99.00"},199.43,"<1","N/A","http://selleckchem.com/products/bay-876.html","C24H16F4N6O2","free base","N/A","CC1=C(NC(=O)C2=CC(=NC3=CC(=CC=C23)F)C(N)=O)C(=N[N]1CC4=CC=C(C=C4)C#N)C(F)(F)F",4.065,4,2,6]
["S8459","TAK-063","e2","L3000-36","in 10mM DMSO","PDE","Metabolism","TAK-063 (Balipodect) is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM.",428.42,"1238697-26-1",{"v":85,"d":"85.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/tak-063.html","C23H17FN6O2","free base","Balipodect","COC1=CN(N=C(C1=O)C2=CC=N[N]2C3=CC=CC=C3)C4=CC=C(C=C4F)[N]5C=CC=N5",3.983,5,0,5]
["S8460","Salermide","f2","L3000-36","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.",394.47,"1105698-15-4",{"v":78,"d":"78.00"},197.73,"<1","N/A","http://selleckchem.com/products/salermide.html","C26H22N2O2","free base","N/A","CC(C(=O)NC1=CC=CC(=C1)N=CC2=C(O)C=CC3=CC=CC=C23)C4=CC=CC=C4",5.374,2,2,5]
["S8464","Citarinostat (ACY-241)","g2","L3000-36","in 10mM DMSO","HDAC","Epigenetics","Citarinostat (ACY-241, HDAC-IN-2) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.",467.95,"1316215-12-9",{"v":41,"d":"41.00"},87.62,"<1","N/A","http://selleckchem.com/products/citarinostat-acy-241.html","C24H26ClN5O3","free base","HDAC-IN-2","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=C(Cl)C=CC=C3",4.582,4,2,11]
["S8465","GSK'872 (GSK2399872A)","h2","L3000-36","in 10mM DMSO","RIP kinase","Apoptosis","GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.",383.49,"1346546-69-7",{"v":76,"d":"76.00"},198.18,"<1","N/A","http://selleckchem.com/products/GSK872-GSK2399872A.html","C19H17N3O2S2","free base","N/A","CC(C)[S](=O)(=O)C1=CC=C2N=CC=C(NC3=CC4=C(SC=N4)C=C3)C2=C1",3.902,4,1,4]
["S8469","CCG-203971","a3","L3000-36","in 10mM DMSO","Rho","Cell Cycle","CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.",408.88,"1443437-74-8",{"v":81,"d":"81.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/ccg-203971.html","C23H21ClN2O3","free base","N/A","ClC1=CC=C(NC(=O)C2CCCN(C2)C(=O)C3=CC(=CC=C3)C4=CC=CO4)C=C1",4.213,3,1,4]
["S8474","LF3","b3","L3000-36","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.",416.56,"664969-54-4",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/lf3.html","C20H24N4O2S2","free base","N/A","N[S](=O)(=O)C1=CC=C(NC(=S)N2CCN(CC2)C\\C=C\\C3=CC=CC=C3)C=C1",3.762,2,2,7]
["S8479","LLY-284","c3","L3000-36","in 10mM DMSO","PRMT","Epigenetics","LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.",342.35,"2226515-75-7",{"v":68,"d":"68.00"},198.63,"<1","N/A","https://www.selleckchem.com/products/lly-284.html","C17H18N4O4","free base","N/A","NC1=NC=NC2=C1C=C[N]2C3OC(C(O)C3O)C(O)C4=CC=CC=C4",0.509,3,4,3]
["S8481","SRT3025 HCl","d3","L3000-36","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.",{"v":606.2,"d":"606.20"},"2070015-26-6",{"v":100,"d":"100.00"},164.96,"<1","N/A","http://selleckchem.com/products/srt3025.html","C31H31N5O2S2.HCl","hydrochloride","N/A","Cl.COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=CC(=CN=C5S4)CN6CCCC6",5.849,5,1,10]
["S8483","CBL0137 HCl","e3","L3000-36","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8489","GSK180736A (GSK180736)","f3","L3000-36","in 10mM DMSO","GRK","GPCR & G Protein","GSK180736A (GSK180736), developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.",365.36,"817194-38-0",{"v":73,"d":"73.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/gsk180736a.html","C19H16FN5O2","free base","N/A","CC1=C(C(NC(=O)N1)C2=CC=C(F)C=C2)C(=O)NC3=CC4=C([NH]N=C4)C=C3",1.843,3,4,3]
["S8493","PD-166866 (PD166866)","g3","L3000-36","in 10mM DMSO","FGFR","Angiogenesis","PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.",396.44,"192705-79-6",{"v":14,"d":"14.00"},35.31,"<1","N/A","http://selleckchem.com/products/pd-166866.html","C20H24N6O3","free base","N/A","COC1=CC(=CC(=C1)C2=CC3=C(N=C(N)N=C3)N=C2NC(=O)NC(C)(C)C)OC",2.279,6,3,5]
["S8494","PF-06726304","h3","L3000-36","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM.",446.33,"1616287-82-1",{"v":10,"d":"10.00"},{"v":22.4,"d":"22.40"},"<1","N/A","http://selleckchem.com/products/pf-06726304.html","C22H21Cl2N3O3","free base","PF-6726304","CC1=CC(=C(CN2CCC3=C(Cl)C=C(C(=C3C2=O)Cl)C4=C(C)ON=C4C)C(=O)N1)C",3.398,4,1,3]
["S8495","WT161","a4","L3000-36","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","WT161 is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 values of 0.4 nM, 8.35 nM and 15.4 nM for HDAC6, HDAC1 and HDAC2, respectively; shown to have >100-fold selectivity over other HDACs. WT161 induces apoptosis.",458.55,"1206731-57-8",{"v":86,"d":"86.00"},187.55,"<1","N/A","http://selleckchem.com/products/wt161.html","C27H30N4O3","free base","N/A","ONC(=O)CCCCCCC(=O)N/N=C/C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",5.406,3,2,12]
["S8496","EED226","b4","L3000-36","in 10mM DMSO","Epigenetic Reader Domain,Histone Methyltransferase","Epigenetics","EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.",{"v":369.4,"d":"369.40"},"2083627-02-3",{"v":73,"d":"73.00"},197.62,"<1","N/A","http://selleckchem.com/products/eed226.html","C17H15N5O3S","free base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)C2=CN=C(NCC3=CC=CO3)[N]4C=NN=C24",2.136,6,1,5]
["S8502","TMP195","c4","L3000-36","in 10mM DMSO","HDAC","Epigenetics","TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with Ki of 59, 60, 26 and 15nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.",456.42,"1314891-22-9",{"v":91,"d":"91.00"},199.38,"<1","N/A","http://selleckchem.com/products/tmp195.html","C23H19F3N4O3","free base","TFMO 2","CC(C)(CNC(=O)C1=CC(=CC=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4",4.525,6,1,7]
["S8503","Fisogatinib (BLU-554)","d4","L3000-36","in 10mM DMSO","FGFR","Angiogenesis","Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.",503.38,"1707289-21-1",{"v":100,"d":"100.00"},198.66,"<1","N/A","http://selleckchem.com/products/blu-554.html","C24H24Cl2N4O4","free base","N/A","COC1=CC(=C(Cl)C(=C1Cl)C2=CC3=C(C=C2)N=C(NC4COCCC4NC(=O)C=C)N=C3)OC",4.229,6,2,7]
["S8511","Belizatinib (TSR-011)","e4","L3000-36","in 10mM DMSO","ALK,Trk receptor","Protein Tyrosine Kinase","\"Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C).\n\n\"",577.73,"1357920-84-3",{"v":100,"d":"100.00"},173.09,"<1","N/A","http://selleckchem.com/products/tsr-011-belizatinib.html","C33H44FN5O3","free base","N/A","CC(C)NC(=O)C1CCC(CC1)N2C(NC3=CC=C(CN4CCC(CC4)C(C)(C)O)C=C23)=NC(=O)C5=CC=C(F)C=C5",4.827,3,2,7]
["S8518","AD80","f4","L3000-36","in 10mM DMSO","c-RET,S6 Kinase,Src","Protein Tyrosine Kinase","AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.",473.43,"1384071-99-1",{"v":94,"d":"94.00"},198.55,"<1","N/A","http://selleckchem.com/products/ad80.html","C22H19F4N7O","free base","N/A","CC(C)[N]1N=C(C2=CC=C(NC(=O)NC3=CC(=CC=C3F)C(F)(F)F)C=C2)C4=C(N)N=CN=C14",4.406,4,3,5]
["S8520","Senexin A","g4","L3000-36","in 10mM DMSO","CDK","Cell Cycle","Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.",274.32,"1366002-50-7",{"v":54,"d":"54.00"},196.85,"<1","N/A","http://selleckchem.com/products/senexin-a.html","C17H14N4","free base","N/A","N#CC1=CC=C2N=CN=C(NCCC3=CC=CC=C3)C2=C1",3.519,2,1,4]
["S8523","GSK2256098","h4","L3000-36","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM. GSK2256098 inhibits cancer cell growth and induces apoptosis.",414.89,"1224887-10-8",{"v":82,"d":"82.00"},197.64,"<1","N/A","http://selleckchem.com/products/gsk2256098.html","C20H23ClN6O2","free base","GTPL7939","CONC(=O)C1=CC=CC=C1NC2=C(Cl)C=NC(=C2)NC3=CC(=N[N]3C(C)C)C",{"v":3.82,"d":"3.820"},4,3,7]
["S8526","GDC-0575 (ARRY-575)","a5","L3000-36","in 10mM DMSO","Chk","Cell Cycle","GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2 nM.",378.27,"1196541-47-5",{"v":75,"d":"75.00"},198.27,"<1","N/A","http://www.selleckchem.com/products/gdc-0575.html","C16H20BrN5O","Free Base","RG7741","NC1CCCN(C1)C2=C(Br)C=NC3=C2C(=C[NH]3)NC(=O)C4CC4",1.621,2,3,3]
["S8534","Temuterkib (LY3214996)","b5","L3000-36","in 10mM DMSO","ERK","MAPK","Temuterkib (LY3214996) is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.",453.56,"1951483-29-6",{"v":27,"d":"27.00"},59.53,"<1","N/A","http://selleckchem.com/products/ly3214996.html","C22H27N7O2S","free base","N/A","C[N]1N=CC=C1NC2=NC(=CC=N2)C3=CC4=C(S3)C(C)(C)N(CCN5CCOCC5)C4=O",2.664,5,1,6]
["S8539","TAS-102","c5","L3000-36","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.",435.76,"733030-01-8",{"v":100,"d":"100.00"},114.74,{"v":15,"d":"15.00"},17.21,"http://selleckchem.com/products/tas-102.html","C10H11F3N2O5.0.5C9H11ClN4O2.0.5HCl","hydrochloride","Trifluridine-Tipiracil Hydrochloride Mixture","Cl.OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F.OCC3OC(CC3O)N4C=C(C(=O)NC4=O)C(F)(F)F.ClC5=C(CN6CCCC6=N)NC(=O)NC5=O",-1.951,8,8,8]
["S8555","Asciminib (ABL001)","d5","L3000-36","in 10mM DMSO","Bcr-Abl","Angiogenesis","Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of 0.5-0.8 nM and selectivity to the myristoyl pocket of ABL1.",449.84,"1492952-76-7",{"v":89,"d":"89.00"},197.85,"N/A","N/A","http://selleckchem.com/products/asciminib-abl001.html","C20H18ClF2N5O3","free base","N/A","OC1CCN(C1)C2=C(C=C(C=N2)C(=O)NC3=CC=C(OC(F)(F)Cl)C=C3)C4=CC=N[NH]4",4.196,4,3,6]
["S8556","AZ31","e5","L3000-36","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ).",{"v":420.5,"d":"420.50"},"2088113-98-6",{"v":53,"d":"53.00"},126.04,"<1","N/A","http://www.selleckchem.com/products/az31.html","C24H28N4O3","Free Base","N/A","COCC1=NC=C(C=C1)C2=CC=C3N=CC(=C(NC(C)C4CCOCC4)C3=C2)C(N)=O",{"v":2.01,"d":"2.010"},5,2,7]
["S8557","IDO inhibitor 1","f5","L3000-36","in 10mM DMSO","IDO/TDO","Metabolism","IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM.",497.63,"1668565-74-9",{"v":99,"d":"99.00"},198.94,"N/A","N/A","http://selleckchem.com/products/ido-inhibitor-1.html","C29H35N7O","free base","N/A","CC(C)CN(CC(C)C)C1=CC=C(C=C1NC(=O)NC2=CC=C(C)C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4",6.102,4,3,9]
["S8558","Tofogliflozin(CSG 452)","g5","L3000-36","in 10mM DMSO","SGLT","GPCR & G Protein","Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.",404.45,"1201913-82-7",{"v":84,"d":"84.00"},207.69,{"v":4,"d":"4.00"},9.89,"http://selleckchem.com/products/tofogliflozin-csg-452.html","C22H26O6.H2O","hydrate","N/A","O.CCC1=CC=C(CC2=CC3=C(COC34OC(CO)C(O)C(O)C4O)C=C2)C=C1",{"v":1.92,"d":"1.920"},2,4,4]
["S8561","HJC0152","h5","L3000-36","in 10mM DMSO","STAT","JAK/STAT","HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.",406.65,"1420290-99-8",{"v":88,"d":"88.00"},{"v":216.4,"d":"216.40"},"<1","N/A","http://selleckchem.com/products/hjc0152.html","C15H13Cl2N3O4.HCl","hydrochloride","N/A","Cl.NCCOC1=C(C=C(Cl)C=C1)C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.374,2,2,6]
["S8562","IRAK4-IN-2","a6","L3000-36","in 10mM DMSO","IL Receptor,IRAK,TLR","Immunology & Inflammation","IRAK4-IN-2 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades.",417.42,"1801343-74-7",{"v":30,"d":"30.00"},71.87,"<1","N/A","https://www.selleckchem.com/products/irak4-in-2.html","C21H19N7O3","free base","N/A","NC1=CC=C(C=N1)C2=CC=CC(=N2)C(=O)NC3=CC4=C(N=C3)N=C(O4)N5CCOCC5",1.443,7,2,4]
["S8564","Verubecestat (MK-8931)","b6","L3000-36","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.",409.41,"1286770-55-5",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/verubecestat.html","C17H17F2N5O3S","free base","N/A","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3",1.314,4,2,3]
["S8567","Tucidinostat (Chidamide)","c6","L3000-36","in 10mM DMSO","HDAC","Epigenetics","Tucidinostat (Chidamide, HBI-8000, CS-055) is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.",390.41,"1616493-44-7",{"v":78,"d":"78.00"},199.79,"<1","N/A","http://selleckchem.com/products/tucidinostat-chidamide.html","C22H19FN4O2","free base","HBI-8000, CS-055","NC1=C(NC(=O)C2=CC=C(CNC(=O)\\C=C\\C3=CC=CN=C3)C=C2)C=C(F)C=C1",2.182,3,3,6]
["S8570","RXDX-106 (CEP-40783)","d6","L3000-36","in 10mM DMSO","Axl,c-Met,Mertk,Tyro3","Protein Tyrosine Kinase","RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.",588.56,"1437321-24-8",{"v":10,"d":"10.00"},16.99,"<1","N/A","http://selleckchem.com/products/rxdx-106-cep-40783.html","C31H26F2N4O6","free base","N/A","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=C(F)C=C(NC(=O)C4=CN(C(C)C)C(=O)N(C4=O)C5=CC=C(F)C=C5)C=C3",4.572,7,1,8]
["S8572","Amcasertib (BBI503)","e6","L3000-36","in 10mM DMSO","Stemness kinase","Stem Cells & Wnt","Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.",539.69,"1129403-56-0",{"v":14,"d":"14.00"},25.94,"<1","N/A","http://selleckchem.com/products/amcasertib-bbi503.html","C31H33N5O2S","free base","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)\\C=C/2C(=O)NC3=CC=C(C=C23)C4=CSC(=N4)C5=CC=CC=C5",5.119,3,3,9]
["S8573","Sitravatinib (MGCD516)","f6","L3000-36","in 10mM DMSO","Axl,c-Kit,Ephrin receptor,Trk receptor,VEGFR","Protein Tyrosine Kinase","Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.",629.68,"1123837-84-2",{"v":100,"d":"100.00"},158.81,"<1","N/A","http://selleckchem.com/products/sitravatinib-mgcd516.html","C33H29F2N5O4S","free base","MG-516","COCCNCC1=CC=C(N=C1)C2=CC3=C(S2)C(=CC=N3)OC4=CC=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4F",5.029,6,3,12]
["S8575","A2AR antagonist 1","g6","L3000-36","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively.",{"v":309.3,"d":"309.30"},"443103-97-7",{"v":61,"d":"61.00"},197.22,"<1","N/A","http://selleckchem.com/products/a2ar-antagonist-1.html","C16H12FN5O","free base","N/A","NC1=NC2=C(C=N[N]2CC3=CC=CC=C3F)C(=N1)C4=CC=CO4",3.005,4,1,3]
["S8576","EAD1","h6","L3000-36","in 10mM DMSO","Autophagy","Autophagy","EAD1 is a potent autophagy inhibitor with an IC50 of 5.8 μM in the BxPC3 cells. It has antiproliferative activities in lung and pancreatic cancer cells.",598.45,"2320427-95-8",{"v":100,"d":"100.00"},{"v":167.1,"d":"167.10"},{"v":100,"d":"100.00"},{"v":167.1,"d":"167.10"},"http://selleckchem.com/products/ead1.html","C26H28Cl2F3N7O2","Trifluoroacetate","N/A","CN(CCNCC1=C[N](CC2=CC=C(Cl)C=C2)N=N1)CCNC3=CC=NC4=CC(=CC=C34)Cl.OC(=O)C(F)(F)F",2.308,4,2,12]
["S8578","PRN1371","a7","L3000-36","in 10mM DMSO","CSF-1R,FGFR","Angiogenesis","PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.",561.46,"1802929-43-6",{"v":100,"d":"100.00"},178.11,"<1","N/A","http://selleckchem.com/products/prn1371.html","C26H30Cl2N6O4","free base","N/A","CNC1=NC=C2C=C(C(=O)N(CCCN3CCN(CC3)C(=O)C=C)C2=N1)C4=C(Cl)C(=CC(=C4Cl)OC)OC",3.438,6,1,9]
["S8580","COTI-2","b7","L3000-36","in 10mM DMSO","p53","Apoptosis","COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.",366.48,"1039455-84-9",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/coti-2.html","C19H22N6S","free base","N/A","S=C(N\\N=C/1CCCC2=C1N=CC=C2)N3CCN(CC3)C4=NC=CC=C4",3.825,3,1,4]
["S8581","Serabelisib (TAK-117)","c7","L3000-36","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.",363.37,"1268454-23-4",{"v":16,"d":"16.00"},44.03,"<1","N/A","http://selleckchem.com/products/tak-117-ink-1117-mln-1117.html","C19H17N5O3","free base","INK-1117, MLN-1117","NC1=NC2=C(O1)C=CC(=C2)C3=C[N]4C(=NC=C4C(=O)N5CCOCC5)C=C3",0.939,5,1,2]
["S8583","Repotrectinib (TPX-0005)","d7","L3000-36","in 10mM DMSO","ALK,ROS1,Src,Trk receptor","Protein Tyrosine Kinase","Repotrectinib (TPX-0005) is a novel ALK/ROS1/TRK inhibitor with the IC50 values of 1.01 nM for WT ALK, 1.26 nM for ALK(G1202R), and 1.08 nM for ALK(L1196M); also a potent SRC inhibitor (IC50 5.3 nM).",355.37,"1802220-02-5",{"v":70,"d":"70.00"},196.98,"<1","N/A","http://selleckchem.com/products/tpx-0005.html","C18H18FN5O2","free base","N/A","CC1CNC(=O)C2=C3N=C(NC(C)C4=C(O1)C=CC(=C4)F)C=C[N]3N=C2",2.005,4,2,0]
["S8588","ACSS2 inhibitor","e7","L3000-36","in 10mM DMSO","ACSS2,RSV","Metabolism","ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).",410.51,"508186-14-9",{"v":30,"d":"30.00"},73.08,"<1","N/A","http://selleckchem.com/products/acss2-inhibitor.html","C20H18N4O2S2","free base","N/A","COCCNC(=O)NC1=CC2=C(C=C1)N=C(C3=CC=CS3)C(=N2)C4=CC=CS4",{"v":4.08,"d":"4.080"},4,2,6]
["S8589","SF2523","f7","L3000-36","in 10mM DMSO","DNA-PK,Epigenetic Reader Domain,mTOR,PI3K","PI3K/Akt/mTOR","SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.",371.41,"1174428-47-7",{"v":29,"d":"29.00"},78.08,"<1","N/A","http://selleckchem.com/products/sf2523.html","C19H17NO5S","free base","N/A","O=C1C=C(OC2=C1SC=C2C3=CC=C4OCCOC4=C3)N5CCOCC5",3.081,5,0,2]
["S8591","FX1","g7","L3000-36","in 10mM DMSO","Apoptosis related,Bcl-6","Apoptosis","FX1 is a selective BCL6 BTB inhibitor with an IC50 value of 35 μM in reporter assays. FX1 shows great selectivity against a panel of 50 different kinases. 10 μM FX1 fails to significantly inhibit of any of these kinases. FX1 induces apoptosis.",368.82,"1426138-42-2",{"v":73,"d":"73.00"},197.93,"<1","N/A","http://selleckchem.com/products/fx1.html","C14H9ClN2O4S2","free base","N/A","OC(=O)CCN1C(=S)SC(/C1=O)=C/2C(=O)NC3=C2C=C(Cl)C=C3",2.356,3,1,3]
["S8592","Pamiparib (BGB-290)","h7","L3000-36","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Pamiparib (BGB-290) is a potent and selective inhibitor of PARP1 and PARP2 with IC50 values of 0.83 and 0.11 nM, respectively in biochemical assays. It shows high selectivity over other PARP enzymes.",298.31,"1446261-44-4",{"v":59,"d":"59.00"},197.78,"<1","N/A","http://www.selleckchem.com/products/bgb-290.html","C16H15FN4O","Free Base","N/A","CC12CCCN1CC3=NNC(=O)C4=CC(=CC5=C4C3=C2[NH]5)F",2.078,2,2,0]
["S8594","Tirofiban Hydrochloride","a8","L3000-36","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.",495.07,"150915-40-5",{"v":95,"d":"95.00"},191.89,{"v":95,"d":"95.00"},191.89,"http://selleckchem.com/products/tirofiban-hydrochlorid.html","C22H36N2O5S.HCl.H2O","hydrochloride hydrate","MK-383 Hydrochloride","O.Cl.CCCC[S](=O)(=O)NC(CC1=CC=C(OCCCCC2CCNCC2)C=C1)C(O)=O",0.922,4,2,14]
["S8596","Autophinib","b8","L3000-36","in 10mM DMSO","Autophagy,PI3K","Autophagy","Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.",346.73,"1644443-47-9",{"v":69,"d":"69.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/autophinib.html","C14H11ClN6O3","free base","N/A","CC1=CC(=N[NH]1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+]([O-])=O)Cl",4.118,4,2,5]
["S8597","LYN-1604","c8","L3000-36","in 10mM DMSO","Autophagy,ULK","Autophagy","LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.",657.54,"2088939-99-3",{"v":50,"d":"50.00"},76.04,{"v":100,"d":"100.00"},152.08,"http://selleckchem.com/products/lyn-1604.html","C33H45Cl4N3O2","dihydrochloride","N/A","Cl.Cl.CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(OCC2=CC=C3C=CC=CC3=C2)C4=CC=C(Cl)C=C4Cl",7.992,2,0,12]
["S8598","S 38093","d8","L3000-36","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.",288.38,"862896-30-8",{"v":57,"d":"57.00"},197.66,"<1","N/A","http://selleckchem.com/products/S-38093.html","C17H24N2O2","free base","N/A","NC(=O)C1=CC=C(OCCCN2CC3CCCC3C2)C=C1",2.201,2,1,6]
["S8605","C188-9","e8","L3000-36","in 10mM DMSO","STAT","JAK/STAT","C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.",471.52,"432001-19-9",{"v":94,"d":"94.00"},199.36,"<1","N/A","http://selleckchem.com/products/c188-9.html","C27H21NO5S","free base","TTI 101","COC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=C(O)C3=CC=CC=C23)C4=C(O)C=CC5=C4C=CC=C5",5.152,3,3,5]
["S8607","JQ-EZ-05 (JQEZ5)","f8","L3000-36","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","JQ-EZ-05 (JQEZ5) is a specific and reversible EZH1/2 inhibitor.",542.68,"1913252-04-6",{"v":24,"d":"24.00"},44.22,"N/A","N/A","http://selleckchem.com/products/jq-ez-05-jqez5.html","C30H38N8O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=NC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.379,5,2,8]
["S8608","Adenosine Dialdehyde (ADOX)","g8","L3000-36","in 10mM DMSO","SAM MTase,Transferase","Metabolism","Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.",265.23,"34240-05-6",{"v":19,"d":"19.00"},71.64,{"v":3,"d":"3.00"},11.31,"http://selleckchem.com/products/adenosine-dialdehyde-adox.html","C10H11N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C(OC(CO)C=O)C=O",-1.346,6,2,6]
["S8609","Derazantinib(ARQ-087)","h8","L3000-36","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT.",468.57,"1234356-69-4",{"v":93,"d":"93.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/derazantinib.html","C29H29FN4O","Free Base","N/A","COCCNCCC1=CC(=CC=C1)NC2=NC3=C(CC(C4=CC=CC=C4F)C5=C3C=CC=C5)C=N2",5.887,3,2,9]
["S8611","Vorasidenib (AG-881)","a9","L3000-36","in 10mM DMSO","Dehydrogenase","Metabolism","Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2).",414.74,"1644545-52-7",{"v":82,"d":"82.00"},197.71,"<1","N/A","http://selleckchem.com/products/ag-881.html","C14H13ClF6N6","free base","N/A","CC(NC1=NC(=NC(=N1)C2=CC=CC(=N2)Cl)NC(C)C(F)(F)F)C(F)(F)F",5.146,4,2,7]
["S8612","α-cyano-4-hydroxycinnamic acid(α-CHCA)","b9","L3000-36","in 10mM DMSO","MCT","Transmembrane Transporters","4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.",189.17,"28166-41-8",{"v":37,"d":"37.00"},195.59,"<1","N/A","http://selleckchem.com/products/alpha-cyano-4-hydroxycinnamic-acid-alpha-chca.html","C10H7NO3","free base","N/A","OC(=O)/C(=C/C1=CC=C(O)C=C1)C#N",1.524,1,1,2]
["S8615","Sodium dichloroacetate (DCA)","c9","L3000-36","in 10mM DMSO","Apoptosis related,Dehydrogenase,NKCC,ROS","Metabolism","Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.",150.92,"2156-56-1",{"v":30,"d":"30.00"},198.78,{"v":30,"d":"30.00"},198.78,"http://selleckchem.com/products/sodium-dichloroacetate-dca.html","C2HCl2O2.Na","sodium salt","Dichloroacetic acid, bichloroacetic acid, BCA","[Na]OC(=O)C(Cl)Cl",1.081,2,0,2]
["S8616","PKM2 inhibitor(compound 3k)","d9","L3000-36","in 10mM DMSO","PKM","Metabolism","PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.",345.48,"94164-88-2",{"v":6,"d":"6.00"},17.37,"<1","N/A","http://selleckchem.com/products/pkm2-inhibitor-compound-3k.html","C18H19NO2S2","free base","PKM2-IN-1","CC1=C(CSC(=S)N2CCCCC2)C(=O)C3=CC=CC=C3C1=O",5.039,2,0,4]
["S8619","NCT-503","e9","L3000-36","in 10mM DMSO","Dehydrogenase","Metabolism","NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with the IC50 value of 2.5 μM. It is inactive against a panel of other dehydrogenases and shows minimal cross-reactivity in a panel of 168 GPCRs.",408.48,"1916571-90-8",{"v":81,"d":"81.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://selleckchem.com/products/nct-503.html","C20H23F3N4S","free base","N/A","CC1=CC(=NC(=C1)C)NC(=S)N2CCN(CC2)CC3=CC=C(C=C3)C(F)(F)F",5.688,1,1,6]
["S8627","OSS_128167","f9","L3000-36","in 10mM DMSO","HBV,Sirtuin","Epigenetics","OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.",366.32,"887686-02-4",{"v":73,"d":"73.00"},199.28,"<1","N/A","http://selleckchem.com/products/oss-128167.html","C19H14N2O6","free base","SIRT6-IN-1","OC(=O)C1=CC(=CC=C1O)NC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=CO3",2.182,4,3,5]
["S8628","3-TYP","g9","L3000-36","in 10mM DMSO","Sirtuin","Cytoskeletal Signaling","3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.",146.15,"120241-79-4",{"v":29,"d":"29.00"},198.43,{"v":5,"d":"5.00"},34.21,"http://selleckchem.com/products/3-typ.html","C7H6N4","free base","3-(1H-1,2,3-triazol-4-yl) pyridine","[NH]1C=C(N=N1)C2=CC=CN=C2",0.602,3,1,1]
["S8629","Linrodostat (BMS-986205)","h9","L3000-36","in 10mM DMSO","IDO/TDO","Metabolism","Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.",410.91,"1923833-60-6",{"v":82,"d":"82.00"},199.56,"<1","N/A","https://www.selleckchem.com/products/bms-986205.html","C24H24ClFN2O","free base","ONO-7701","CC(C1CCC(CC1)C2=CC=NC3=C2C=C(F)C=C3)C(=O)NC4=CC=C(Cl)C=C4",6.125,2,1,4]
["S8632","Chk2 Inhibitor II (BML-277)","a10","L3000-36","in 10mM DMSO","Apoptosis related,Chk","Cell Cycle","Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Chk2 Inhibitor II (BML-277) dose dependently protects human CD4(+) and CD8(+) T-cells from apoptosis due to ionizing radiation.",{"v":363.8,"d":"363.80"},"516480-79-8",{"v":72,"d":"72.00"},197.91,"<1","N/A","http://selleckchem.com/products/chk2-inhibitor-2-bml-277.html","C20H14ClN3O2","free base","N/A","NC(=O)C1=CC=C2[NH]C(=NC2=C1)C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3",4.497,3,2,4]
["S8639","Diphenyleneiodonium chloride (DPI)","b10","L3000-36","in 10mM DMSO","NADPH-oxidase,NOS,ROS,TRP Channel","Immunology & Inflammation","Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).",314.55,"4673-26-1",{"v":13,"d":"13.00"},41.33,"<1","N/A","http://selleckchem.com/products/diphenyleneiodonium-chloride-dpi.html","C12H8I.Cl","chloride","N/A","[Cl-].[I+]1C2=CC=CC=C2C3=C1C=CC=C3",1.101,0,0,0]
["S8640","Reparixin (Repertaxin)","c10","L3000-36","in 10mM DMSO","CXCR","Immunology & Inflammation","Reparixin (Repertaxin, DF 1681Y) is a potent and specific inhibitor of CXCR1 with IC50 of 1 nM. Reparixin (Repertaxin) inhibits PMN migration induced by CXCL8 (IC50 = 1 nM) and rodent PMN chemotaxis induced by CXCL1 and CXCL2. Repertaxin inhibits the response of human PMN to CXCL1, which interacts with CXCR2 (IC50 = 400 nM).",283.39,"266359-83-5",{"v":56,"d":"56.00"},197.61,"<1","N/A","http://selleckchem.com/products/reparixin-repertaxin.html","C14H21NO3S","free base","DF 1681Y","CC(C)CC1=CC=C(C=C1)C(C)C(=O)N[S](C)(=O)=O",{"v":2.76,"d":"2.760"},3,1,5]
["S8641","Necrostatin 2 racemate (Nec-1s)","d10","L3000-36","in 10mM DMSO","RIP kinase","Apoptosis","Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.",277.71,"852391-15-2",{"v":56,"d":"56.00"},201.65,"<1","N/A","http://www.selleckchem.com/products/nec-1s-7-cl-o-nec1.html","C13H12ClN3O2","racemate","7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S","CN1C(=O)NC(CC2=C[NH]C3=C(Cl)C=CC=C23)C1=O",2.043,2,2,2]
["S8644","GNF-6231","e10","L3000-36","in 10mM DMSO","PORCN","Stem Cells & Wnt","GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.",448.49,"1243245-18-2",{"v":89,"d":"89.00"},198.44,"<1","N/A","http://selleckchem.com/products/gnf-6231.html","C24H25FN6O2","free base","N/A","CC(=O)N1CCN(CC1)C2=CC=C(NC(=O)CC3=CC(=C(N=C3)C4=CC(=NC=C4)F)C)N=C2",2.135,5,1,5]
["S8645","IWP-O1","f10","L3000-36","in 10mM DMSO","PORCN","Stem Cells & Wnt","IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.",432.48,"2074607-48-8",{"v":86,"d":"86.00"},198.85,"<1","N/A","http://selleckchem.com/products/iwp-O1.html","C26H20N6O","free base","N/A","O=C(C[N]1N=NC(=C1C2=CC=CC=C2)C3=CC=NC=C3)NC4=NC=C(C=C4)C5=CC=CC=C5",4.161,5,1,6]
["S8647","iCRT3","g10","L3000-36","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.",394.53,"901751-47-1",{"v":78,"d":"78.00"},{"v":197.7,"d":"197.70"},"<1","N/A","http://selleckchem.com/products/icrt3.html","C23H26N2O2S","free base","N/A","CCC1=CC=C(C=C1)C2=NC(=C(C)O2)CSCC(=O)NCCC3=CC=CC=C3",4.468,3,1,9]
["S8648","ACY-738","h10","L3000-36","in 10mM DMSO","HDAC","Epigenetics","ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.",270.29,"1375465-91-0",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/acy-738.html","C14H14N4O2","free base","N/A","ONC(=O)C1=CN=C(NC2(CC2)C3=CC=CC=C3)N=C1",1.325,3,2,4]
["S8650","BTSA1","a11","L3000-36","in 10mM DMSO","Bcl-2","Apoptosis","BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.",430.51,"314761-14-3",{"v":81,"d":"81.00"},188.15,"<1","N/A","http://selleckchem.com/products/btsa1.html","C21H14N6OS2","free base","N/A","O=C1N(N=C(C2=CC=CC=C2)\\C1=N/NC3=NC=CS3)C4=NC(=CS4)C5=CC=CC=C5",4.439,5,1,5]
["S8652","Skp2 inhibitor C1 (SKPin C1)","b11","L3000-36","in 10mM DMSO","E3 Ligase","Ubiquitin","Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.",465.34,"432001-69-9",{"v":93,"d":"93.00"},199.85,"<1","N/A","http://selleckchem.com/products/skp2-inhibitor-c1-skpin-c1.html","C18H13BrN2O4S2","free base/salt","N/A","OC(=O)COC1=C(C=C(Br)C=C1)\\C=C2/SC(=S)N(CC3=CN=CC=C3)C2=O",3.693,4,0,6]
["S8654","ex229 (compound 991)","c11","L3000-36","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.",431.87,"1219739-36-2",{"v":12,"d":"12.00"},27.79,"<1","N/A","http://www.selleckchem.com/products/ex229-compound-991.html","C24H18ClN3O3","Free Base","N/A","C[N]1C=CC2=C1C=CC(=C2)C3=C(Cl)C=C4[NH]C(=NC4=C3)OC5=CC(=C(C)C=C5)C(O)=O",6.245,3,1,4]
["S8657","PF-06840003","d11","L3000-36","in 10mM DMSO","IDO/TDO","Metabolism","PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.",232.21,"198474-05-4",{"v":46,"d":"46.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pf-06840003.html","C12H9FN2O2","free base","EOS200271","FC1=CC=C2[NH]C=C(C3CC(=O)NC3=O)C2=C1",1.201,2,2,1]
["S8660","GI254023X","e11","L3000-36","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.GI254023X can inhibit MMP9.",{"v":391.5,"d":"391.50"},"260264-93-5",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://selleckchem.com/products/gi254023x.html","C21H33N3O4","free base","GI 4023, SRI028594","CNC(=O)C(NC(=O)C(CCCC1=CC=CC=C1)C(C)N(O)C=O)C(C)(C)C",2.517,3,2,10]
["S8661","CA3 (CIL56)","f11","L3000-36","in 10mM DMSO","Ferroptosis,ROS,TEAD,YAP","Hippo","CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).",489.61,"300802-28-2",{"v":97,"d":"97.00"},198.12,"<1","N/A","http://selleckchem.com/products/ca3.html","C23H27N3O5S2","free base","N/A","O/N=C1/C2=CC(=CC=C2C3=C1C=C(C=C3)[S](=O)(=O)N4CCCCC4)[S](=O)(=O)N5CCCCC5",3.058,5,0,4]
["S8662","PTC-028","g11","L3000-36","in 10mM DMSO","BMI-1","Cell Cycle","PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification.",405.32,"1782970-28-8",{"v":81,"d":"81.00"},199.84,"<1","N/A","http://selleckchem.com/products/ptc-028.html","C19H12F5N5","free base","N/A","CC1=NC2=C(C=C(F)C(=C2)F)[N]1C3=CN=CC(=N3)NC4=CC=C(C=C4)C(F)(F)F",5.069,3,1,4]
["S8663","Takinib (EDHS-206)","h11","L3000-36","in 10mM DMSO","Apoptosis related,IRAK,TAK1","MAPK","Takinib (EDHS-206) is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM, more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib induces apoptosis.",322.36,"1111556-37-6",{"v":64,"d":"64.00"},198.54,"<1","N/A","http://selleckchem.com/products/takinib.html","C18H18N4O2","free base","EDHS-206","CCC[N]1C(=NC2=CC=CC=C12)NC(=O)C3=CC(=CC=C3)C(N)=O",2.752,3,2,5]
["S8664","Pemrametostat (GSK3326595)","a2","L3000-37","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.",452.55,"1616392-22-3",{"v":90,"d":"90.00"},198.87,"<1","N/A","http://selleckchem.com/products/gsk3326595-epz015938.html","C24H32N6O3","free base","EPZ015938","CC(=O)N1CCC(CC1)NC2=CC(=NC=N2)C(=O)NCC(O)CN3CCC4=C(C3)C=CC=C4",0.692,4,3,7]
["S8666","Elimusertib (BAY-1895344) hydrochloride","b2","L3000-37","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.",411.89,"1876467-74-1(free base)",{"v":82,"d":"82.00"},199.08,{"v":82,"d":"82.00"},199.08,"https://www.selleckchem.com/products/bay-1895344-hcl.html","C20H22ClN7O","hydrochloride","BAY-1895344 HCl","Cl.CC1COCCN1C2=CC(=C3C=CN=C(C4=CC=N[NH]4)C3=N2)C5=CC=N[N]5C",3.156,5,1,3]
["S8672","Tenalisib (RP6530)","c2","L3000-37","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.",415.42,"1639417-53-0",{"v":75,"d":"75.00"},180.54,"<1","N/A","http://selleckchem.com/products/tenalisib-rp6530.html","C23H18FN5O2","free base","N/A","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=C(C(=O)C4=CC=CC=C4O3)C5=CC=CC(=C5)F",{"v":4.07,"d":"4.070"},5,2,5]
["S8673","ONC212","d2","L3000-37","in 10mM DMSO","GPR","GPCR & G Protein","ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132. ONC212 is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity.",440.46,"1807861-48-8",{"v":88,"d":"88.00"},199.79,"<1","N/A","http://selleckchem.com/products/onc212.html","C24H23F3N4O","free base","N/A","FC(F)(F)C1=CC=C(CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25)C=C1",3.668,2,0,5]
["S8675","H3B-6527","e2","L3000-37","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3 (IC50 values of 320, 1,290 and 1,060 nM respectively).",629.54,"1702259-66-2",{"v":50,"d":"50.00"},79.42,"<1","N/A","http://selleckchem.com/products/h3b-6527.html","C29H34Cl2N8O4","free base","N/A","CCN1CCN(CC1)C2=CC(=C(NC3=CC(=NC=N3)N(C)C(=O)NC4=C(Cl)C(=CC(=C4Cl)OC)OC)C=C2)NC(=O)C=C",{"v":5.16,"d":"5.160"},6,3,10]
["S8676","Glumetinib (SCC244)","f2","L3000-37","in 10mM DMSO","c-Met,RON","Protein Tyrosine Kinase","Glumetinib (SCC244) is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3.",459.48,"1642581-63-2",{"v":11,"d":"11.00"},23.94,"<1","N/A","http://www.selleck.cn/products/glumetinib.html","C21H17N9O2S","free base","N/A","C[N]1C=C(C=N1)C2=C[N]3C(=NC=C3[S](=O)(=O)[N]4N=CC5=NC=C(C=C45)C6=C[N](C)N=C6)C=C2",1.725,7,0,4]
["S8677","Cu-CPT22","g2","L3000-37","in 10mM DMSO","TLR","Immunology & Inflammation","CU-CPT22 shows dose-dependent inhibitory effects blocking Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 ± 0.09 µM while no significant inhibition to TLR2/6. It demonstrates minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4).",362.37,"1416324-85-0",{"v":72,"d":"72.00"},198.69,"<1","N/A","http://selleckchem.com/products/cu-cpt22.html","C19H22O7","free base","N/A","CCCCCCOC(=O)C1=CC2=C(C(=C(O)C(=C2)OC)O)C(=O)C(=C1)O",3.358,4,3,8]
["S8680","AZD1390","h2","L3000-37","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.",477.57,"2089288-03-7",{"v":14,"d":"14.00"},29.32,"<1","N/A","http://selleckchem.com/products/azd1390.html","C27H32FN5O2","free base","N/A","CC(C)N1C(=O)N(C)C2=C1C3=CC(=C(F)C=C3N=C2)C4=CC=C(OCCCN5CCCCC5)N=C4",4.231,4,0,7]
["S8685","AS1517499","a3","L3000-37","in 10mM DMSO","STAT","JAK/STAT","AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.",397.86,"919486-40-1",{"v":79,"d":"79.00"},198.56,"<1","N/A","http://selleckchem.com/products/as1517499.html","C20H20ClN5O2","free base","N/A","NC(=O)C1=CN=C(NCCC2=CC=C(O)C(=C2)Cl)N=C1NCC3=CC=CC=C3",3.641,3,4,8]
["S8686","PHTPP","b3","L3000-37","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","PHTPP is an ERβ selective antagonist with 36-fold selective for ER βover ERα.",423.31,"805239-56-9",{"v":50,"d":"50.00"},118.12,"<1","N/A","http://selleckchem.com/products/phtpp.html","C20H11F6N3O","free base","N/A","OC1=CC=C(C=C1)C2=C3N=C(C=C([N]3N=C2C4=CC=CC=C4)C(F)(F)F)C(F)(F)F",6.068,2,1,4]
["S8689","Abequolixron (RGX-104)","c3","L3000-37","in 10mM DMSO","Liver X Receptor","Metabolism","Abequolixron (RGX-104) is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene.",632.54,"610318-03-1",{"v":100,"d":"100.00"},158.09,"<1","N/A","http://www.selleckchem.com/products/rgx-104.html","C34H34Cl2F3NO3","Free Base","N/A","Cl.CC(CCOC1=CC=CC(=C1)CC(O)=O)N(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F",{"v":5.85,"d":"5.850"},2,0,14]
["S8690","RAF709","d3","L3000-37","in 10mM DMSO","Raf","MAPK","RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.",542.55,"1628838-42-5",{"v":100,"d":"100.00"},184.31,"<1","N/A","http://selleckchem.com/products/raf709.html","C28H29F3N4O4","free base","N/A","CC1=NC=C(NC(=O)C2=CC=CC(=C2)C(F)(F)F)C=C1C3=CC(=C(OC4CCOCC4)N=C3)N5CCOCC5",{"v":3.27,"d":"3.270"},6,1,7]
["S8691","ML204","e3","L3000-37","in 10mM DMSO","TRP Channel","Transmembrane Transporters","ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.",226.32,"5465-86-1",{"v":45,"d":"45.00"},198.83,"N/A","N/A","http://selleckchem.com/products/ml204.html","C15H18N2","free base","N/A","CC1=CC(=NC2=CC=CC=C12)N3CCCCC3",4.121,1,0,1]
["S8694","CID16020046","f3","L3000-37","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","CID16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast. It demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptor.",425.44,"834903-43-4",{"v":85,"d":"85.00"},199.79,"<1","N/A","https://www.selleckchem.com/products/cid16020046.html","C25H19N3O4","free base","C390-0219","CC1=CC=C(C=C1)C2=N[NH]C3=C2C(N(C3=O)C4=CC=C(C=C4)C(O)=O)C5=CC=CC(=C5)O",4.742,3,2,4]
["S8696","2-D08","g3","L3000-37","in 10mM DMSO","SUMO","Ubiquitin","2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation.",270.24,"144707-18-6",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/2-d08.html","C15H10O5","free base","2',3',4'-trihydroxy flavone","OC1=CC=C(C(=C1O)O)C2=CC(=O)C3=CC=CC=C3O2",{"v":2.41,"d":"2.410"},2,3,1]
["S8699","SNS-314 Mesylate","h3","L3000-37","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.",527.04,"1146618-41-8",{"v":100,"d":"100.00"},189.74,"<1","N/A","http://selleckchem.com/products/sns-314.html","C18H15ClN6OS2.CH4O3S","Mesylate","N/A","ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.953,4,3,6]
["S8701","MK-8353 (SCH900353)","a4","L3000-37","in 10mM DMSO","ERK","MAPK","MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).",691.84,"1184173-73-6",{"v":50,"d":"50.00"},72.27,"<1","N/A","http://www.selleck.cn/products/mk-8353-sch900353.html","C37H41N9O3S","Free Base","N/A","CSC1(CCN(CC(=O)N2CCC(=CC2)C3=CC=C(C=C3)C4=N[N](C)C=N4)C1)C(=O)NC5=CC=C6[NH]N=C(C7=CC=C(OC(C)C)N=C7)C6=C5",4.176,7,2,10]
["S8704","iCRT14","b4","L3000-37","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","iCRT14 is a β-catenin/Tcf inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay.",375.44,"677331-12-3",{"v":37,"d":"37.00"},98.55,"<1","N/A","http://www.selleck.cn/products/icrt14.html","C21H17N3O2S","free base","N/A","CC1=CC(=C(C)[N]1C2=CN=CC=C2)\\C=C3/SC(=O)N(C4=CC=CC=C4)C3=O",3.741,3,0,3]
["S8706","UM-164","c4","L3000-37","in 10mM DMSO","p38 MAPK,Src","Protein Tyrosine Kinase","UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.",640.68,"903564-48-7",{"v":100,"d":"100.00"},156.08,"<1","N/A","http://selleckchem.com/products/um-164.html","C30H31F3N8O3S","free base","N/A","CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(F)(F)F)N5CCN(CCO)CC5",4.501,5,4,10]
["S8711","Nemtabrutinib (ARQ 531)","d4","L3000-37","in 10mM DMSO","BTK","Angiogenesis","Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.",478.93,"2095393-15-8",{"v":95,"d":"95.00"},198.36,"<1","N/A","https://www.selleckchem.com/products/arq531.html","C25H23ClN4O4","free base","MK-1026","OCC1CCC(CO1)NC2=C3C(=NC=N2)[NH]C=C3C(=O)C4=CC=C(OC5=CC=CC=C5)C=C4Cl",4.368,5,3,7]
["S8714","INCB057643","e4","L3000-37","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones.",415.46,"1820889-23-3",{"v":83,"d":"83.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/incb057643.html","C20H21N3O5S","Free Base","N/A","CN1C=C(C2=C([NH]C=C2)C1=O)C3=CC(=CC4=C3OC(C)(C)C(=O)N4C)[S](C)(=O)=O",1.114,5,1,2]
["S8721","PDGFR inhibitor 1","f4","L3000-37","in 10mM DMSO","c-Kit,CSF-1R,PDGFR,VEGFR","Protein Tyrosine Kinase","PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of Kit (c-Kit) and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.",489.47,"1225278-16-9",{"v":97,"d":"97.00"},198.17,"<1","N/A","https://www.selleckchem.com/products/pdgfr-inhibitor-1.html","C26H21F2N5O3","free base/salt","N/A","C[N]1C=C(C=N1)C2=NC=CC(=C2)OC3=CC(=C(NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)C=C3F)F",3.841,5,2,7]
["S8723","ABBV-744","g4","L3000-37","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.",491.55,"2138861-99-9",{"v":98,"d":"98.00"},199.37,"<1","N/A","http://www.selleckchem.com/products/abbv-744.html","C28H30FN3O4","Free Base","N/A","CCNC(=O)C1=CC2=C([NH]1)C(=O)N(C)C=C2C3=C(OC4=C(C)C=C(F)C=C4C)C=CC(=C3)C(C)(C)O",{"v":4.36,"d":"4.360"},3,2,6]
["S8725","A-804598","h4","L3000-37","in 10mM DMSO","P2 Receptor","Neuronal Signaling","A-804598 is a selective P2X7R antagonist with high affinity at rat (IC50 = 10 nM), mouse (IC50 = 9 nM) and human (IC50 = 11 nM) P2X7 receptors.",315.37,"1125758-85-1",{"v":63,"d":"63.00"},199.77,"<1","N/A","http://selleckchem.com/products/a-804598.html","C19H17N5","free base","N/A","CC(NC(NC#N)=NC1=C2C=CC=NC2=CC=C1)C3=CC=CC=C3",3.286,2,2,5]
["S8726","Anlotinib (AL3818) dihydrochloride","a5","L3000-37","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Anlotinib (AL3818) is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. It has broad-spectrum antitumor potential in clinical trials. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.",480.36,"1360460-82-7",{"v":96,"d":"96.00"},199.85,{"v":96,"d":"96.00"},199.85,"http://selleckchem.com/products/anlotinib-al3818.html","C23H22FN3O3.2HCl","dihydrochloride","N/A","Cl.Cl.COC1=C(OCC2(N)CC2)C=C3N=CC=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.469,4,2,6]
["S8727","Atuveciclib (BAY-1143572)","b5","L3000-37","in 10mM DMSO","CDK","Cell Cycle","Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.",387.43,"1414943-88-6",{"v":77,"d":"77.00"},198.75,"<1","N/A","http://www.selleckchem.com/products/atuveciclib-bay-1143572.html","C18H18FN5O2S","Free Base","N/A","COC1=CC(=CC=C1C2=NC(=NC=N2)NC3=CC(=CC=C3)C[S](C)(=N)=O)F",3.699,5,1,6]
["S8728","PK11000","c5","L3000-37","in 10mM DMSO","p53","Apoptosis","PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.",236.63,"38275-34-2",{"v":47,"d":"47.00"},198.62,{"v":47,"d":"47.00"},198.62,"https://www.selleckchem.com/products/pk11000.html","C6H5ClN2O4S","free base","N/A","C[S](=O)(=O)C1=NC=C(Cl)C(=N1)C(O)=O",{"v":0.82,"d":"0.820"},5,0,2]
["S8729","AZ32","d5","L3000-37","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.",328.37,"2288709-96-4",{"v":66,"d":"66.00"},200.99,"<1","N/A","http://www.selleckchem.com/products/az32.html","C20H16N4O","Free Base","N/A","CNC(=O)C1=CC=C(C=C1)C2=CN=C3C=NC(=C[N]23)C4=CC=CC=C4",2.521,3,1,3]
["S8731","IACS-010759 (IACS-10759)","e5","L3000-37","in 10mM DMSO","OXPHOS","Apoptosis","IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.",562.56,"1570496-34-2",{"v":27,"d":"27.00"},47.99,"<1","N/A","http://www.selleckchem.com/products/iacs-010759-iacs-10759.html","C25H25F3N6O4S","Free Base","N/A","CC1=NC(=N[N]1CC2=CC(=CC=C2)N3CCC(CC3)[S](C)(=O)=O)C4=NC(=NO4)C5=CC=C(OC(F)(F)F)C=C5",4.909,8,0,8]
["S8735","BI-3812","f5","L3000-37","in 10mM DMSO","Bcl-6","Apoptosis","BI-3812 is a highly potent and efficacious BCL6 inhibitor probe compound with an IC50 less than 3 nM.",558.03,"2166387-64-8",{"v":25,"d":"25.00"},{"v":44.8,"d":"44.80"},"<1","N/A","http://www.selleck.cn/products/bi-3812.html","C26H32ClN7O5","free base","N/A","CNC(=O)COC1=CC2=C(N(C)C1=O)C(=CC(=C2)NC3=NC(=NC=C3Cl)N4CCC(CC4)C(=O)N(C)C)OC",1.733,7,2,8]
["S8736","Verinurad (RDEA3170)","g5","L3000-37","in 10mM DMSO","OAT","Transmembrane Transporters","Verinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter with an IC50 of 25 nM for inhibiting transport activity of human URAT1. It inhibits the related URAT1 homologs OAT4 and OAT1 with approximately 200-fold lower affinity compared to URAT1 with IC50 values of 5.9 µM and 4.6 µM, respectively.",348.42,"1352792-74-5",{"v":70,"d":"70.00"},200.91,"<1","N/A","http://selleckchem.com/products/verinurad-rdea3170.html","C20H16N2O2S","free base","N/A","CC(C)(SC1=C(C=NC=C1)C2=C3C=CC=CC3=C(C=C2)C#N)C(O)=O",3.804,2,0,4]
["S8738","Bimiralisib (PQR309)","h5","L3000-37","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.",411.38,"1225037-39-7",{"v":6,"d":"6.00"},14.59,"<1","N/A","http://www.selleckchem.com/products/pqr309-bimiralisib.html","C17H20F3N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C(=C1)C(F)(F)F",1.891,6,1,4]
["S8739","PLX51107","a6","L3000-37","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range).",438.48,"1627929-55-8",{"v":88,"d":"88.00"},200.69,"<1","N/A","http://www.selleck.cn/products/plx51107.html","C26H22N4O3","Free Base","N/A","CC([N]1C=C(C2=CC=C(C=C2)C(O)=O)C3=NC=C(C=C13)C4=C(C)ON=C4C)C5=CC=CC=N5",4.288,5,0,5]
["S8741","Avitinib (AC0010)","b6","L3000-37","in 10mM DMSO","BTK,EGFR","Protein Tyrosine Kinase","Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.",487.53,"1557267-42-1",{"v":97,"d":"97.00"},198.96,"<1","N/A","http://www.selleckchem.com/products/avitinib-ac0010.html","C26H26FN7O2","Free Base","Abivertinib","CN1CCN(CC1)C2=C(F)C=C(NC3=NC4=C(C=C[NH]4)C(=N3)OC5=CC(=CC=C5)NC(=O)C=C)C=C2",4.857,4,3,7]
["S8743","SKLB-23bb","c6","L3000-37","in 10mM DMSO","HDAC","Epigenetics","SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.",396.44,"1815580-06-3",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://www.selleck.cn/products/sklb-23bb.html","C21H24N4O4","free base","N/A","COC1=C(OCCCC(=O)NO)C=C(C=C1)N(C)C2=NC(=NC3=CC=CC=C23)C",3.042,5,1,8]
["S8744","PHY34","d6","L3000-37","in 10mM DMSO","Autophagy","Autophagy","PHY34 is a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo.",582.55,"2130033-55-3",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://www.selleckchem.com/products/phy34.html","C30H30O12","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=C3C(=O)OCC3=C2OC4OC(CO)C5OC(C)(C)OC5C4O)C6=CC=C7OCOC7=C6",2.164,10,2,6]
["S8745","Naporafenib (LXH254)","e6","L3000-37","in 10mM DMSO","Raf","MAPK","Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.",502.49,"1800398-38-2",{"v":100,"d":"100.00"},199.01,"<1","N/A","http://www.selleckchem.com/products/lxh254.html","C25H25F3N4O4","Free Base","N/A","CC1=CC=C(NC(=O)C2=CC(=NC=C2)C(F)(F)F)C=C1C3=CC(=NC(=C3)OCCO)N4CCOCC4",4.061,5,2,8]
["S8746","H3B-5942","f6","L3000-37","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","H3B-5942 is a selective and irreversible estrogen receptor covalent antagonist, inactivates both ERα WT and ERα mutation. The Ki values are 1 nM and 0.41 nM, respectively.",494.63,"2052128-15-9",{"v":99,"d":"99.00"},200.15,"<1","N/A","http://www.selleck.cn/products/h3b-5942.html","C31H34N4O2","free base","N/A","CC\\C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC\\C=C\\C(=O)N(C)C)C=C2)/C3=CC4=C([NH]N=C4)C=C3",5.374,3,2,11]
["S8747","BAY-8002","g6","L3000-37","in 10mM DMSO","MCT","Transmembrane Transporters","BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.",415.85,"724440-27-1",{"v":83,"d":"83.00"},199.59,"<1","N/A","http://www.selleck.cn/products/bay-8002.html","C20H14ClNO5S","Free Base","N/A","OC(=O)C1=C(NC(=O)C2=C(Cl)C=CC(=C2)[S](=O)(=O)C3=CC=CC=C3)C=CC=C1",4.011,4,1,5]
["S8749","MBQ-167","h6","L3000-37","in 10mM DMSO","Rho","Cell Cycle","MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.",338.41,"2097938-73-1",{"v":68,"d":"68.00"},200.94,"<1","N/A","http://www.selleckchem.com/products/mbq-167.html","C22H18N4","Free Base","N/A","CC[N]1C2=C(C=CC=C2)C3=CC(=CC=C13)[N]4N=NC=C4C5=CC=CC=C5",5.446,2,0,3]
["S8750","NGI-1 (ML414)","a7","L3000-37","in 10mM DMSO","Antiviral","Microbiology","NGI-1 (ML414) is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit antiviral activity against flaviviruses.",394.51,"790702-57-7",{"v":79,"d":"79.00"},200.25,"<1","N/A","http://www.selleckchem.com/products/ngi-1ml414.html","C17H22N4O3S2","Free Base","N/A","CN(C)[S](=O)(=O)C1=CC=C(N2CCCC2)C(=C1)C(=O)NC3=NC=C(C)S3",1.497,4,1,5]
["S8753","INCB054329","b7","L3000-37","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","INCB054329 (INCB-054329, INCB-54329) is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM for BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2, respectively.",348.36,"1628607-64-6",{"v":70,"d":"70.00"},200.94,"˂1","N/A","http://www.selleck.cn/products/incb054329.html","C19H16N4O3","Free Base","INCB-054329, INCB-54329","CC1=C(C(=NO1)C)C2=CC=C3NC(=O)N4C(COC2=C34)C5=NC=CC=C5",1.884,5,1,2]
["S8754","Alofanib (RPT835)","c7","L3000-37","in 10mM DMSO","FGFR","Angiogenesis","Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.",{"v":413.4,"d":"413.40"},"1612888-66-0",{"v":83,"d":"83.00"},200.77,"<1","N/A","http://www.selleckchem.com/products/alofanib-rpt835.html","C19H15N3O6S","Free Base","N/A","CC1=CC(=C(N[S](=O)(=O)C2=CC=CC(=C2)C(O)=O)C=C1C3=CC=CN=C3)[N+]([O-])=O",2.695,4,1,6]
["S8755","AZ304","d7","L3000-37","in 10mM DMSO","Raf","MAPK","AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies.",451.52,"942507-42-8",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://www.selleck.cn/products/az304.html","C27H25N5O2","free base","N/A","COC1=CC2=C(C=C1)C(=NC=N2)NC3=CC(=CC=C3C)NC(=O)C4=CC=CC(=C4)C(C)(C)C#N",5.524,4,2,6]
["S8756","XRK3F2","e7","L3000-37","in 10mM DMSO","Others,RUNX","Cell Cycle","XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.",435.89,"2375193-43-2",{"v":87,"d":"87.00"},199.59,"<1","N/A","http://www.selleckchem.com/products/xrk3f2.html","C23H24ClF2NO3","Free Base","N/A","Cl.OCCNCC1=CC=C(OCC2=CC=C(F)C=C2)C(=C1)OCC3=CC=C(F)C=C3",4.755,2,2,10]
["S8757","Ripretinib (DCC-2618)","f7","L3000-37","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.",510.36,"1442472-39-0",{"v":100,"d":"100.00"},195.94,"<1","N/A","http://www.selleckchem.com/products/ripretinib-dcc-2618.html","C24H21BrFN5O2","Free Base","N/A","CCN1C(=O)C(=CC2=C1C=C(NC)N=C2)C3=C(Br)C=C(F)C(=C3)NC(=O)NC4=CC=CC=C4",4.129,3,3,5]
["S8759","S55746","g7","L3000-37","in 10mM DMSO","Bcl-2","Apoptosis","S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.",710.82,"1448584-12-0",{"v":100,"d":"100.00"},140.68,"<1","N/A","http://www.selleckchem.com/products/s55746-s055746-bcl201.html","C43H42N4O6","Free Base","S 055746,BCL201","OC1=CC=C(C=C1)N(C(=O)C2=C3CCCC[N]3C(=C2)C4=C(C=C5OCOC5=C4)C(=O)N6CC7=C(CC6CN8CCOCC8)C=CC=C7)C9=CC=CC=C9",6.817,5,1,7]
["S8760","Iberdomide (CC220)","h7","L3000-37","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,Immunology & Inflammation related","Immunology & Inflammation","Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.",{"v":449.5,"d":"449.50"},"1323403-33-3",{"v":90,"d":"90.00"},200.22,"<1","N/A","http://www.selleck.cn/products/iberdomide.html","C25H27N3O5","free base","N/A","O=C1CCC(N2CC3=C(OCC4=CC=C(CN5CCOCC5)C=C4)C=CC=C3C2=O)C(=O)N1",{"v":1.56,"d":"1.560"},5,1,6]
["S8761","Adavivint (SM04690)","a8","L3000-37","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.",505.55,"1467093-03-3",{"v":30,"d":"30.00"},59.34,"<1","N/A","http://www.selleckchem.com/products/adavivint.html","C29H24FN7O","Free Base","Lorecivivint","CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C([NH]N=C3C4=NC5=C([NH]4)C(=CN=C5)C6=CC=CC(=C6)F)C=C2",4.779,5,3,6]
["S8762","dBET6","b8","L3000-37","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Myc,PROTAC","Epigenetics","dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis.",841.37,"1950634-92-0",{"v":100,"d":"100.00"},118.85,"<1","N/A","http://www.selleck.cn/products/dbet6.html","C42H45ClN8O7S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCCCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C6CCC(=O)NC6=O)C5=O)N=C2C7=CC=C(Cl)C=C7)C",{"v":4.8,"d":"4.800"},10,3,16]
["S8764","IITZ-01","c8","L3000-37","in 10mM DMSO","Autophagy","Autophagy","IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.",482.51,"1807988-47-1",{"v":100,"d":"100.00"},207.25,"<1","N/A","http://www.selleckchem.com/products/iitz-01.html","C26H23FN8O","Free Base","N/A","FC1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)NC4=CC=C(C=C4)C5=NC6=C([NH]5)C=CC=C6)C=C1",6.104,5,3,6]
["S8769","Tinostamustine(EDO-S101)","d8","L3000-37","in 10mM DMSO","HDAC","Epigenetics","Tinostamustine(EDO-S101) is a first-in-class alkylating deacetylase inhibitor with IC50 values of 9 nM, 9 nM, 25 nM and 107 nM for HDAC1, HDAC2, HDAC3 and HDAC8 (Class 1 HDACs) respectively and 6 nM, 72 nM for HDAC6 and HDAC10 (Class II HDACs).",415.36,"1236199-60-2",{"v":14,"d":"14.00"},33.71,"<1","N/A","http://www.selleck.cn/products/tinostamustine.html","C19H28Cl2N4O2","Free Base","N/A","C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCCCCC(=O)NO",{"v":4.36,"d":"4.360"},2,1,12]
["S8770","Lanifibranor (IVA-337)","e8","L3000-37","in 10mM DMSO","PPAR","Metabolism","Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively.",434.92,"927961-18-0",{"v":87,"d":"87.00"},200.04,"<1","N/A","http://www.selleckchem.com/products/lanifibranor-iva-337.html","C19H15ClN2O4S2","Free Base","N/A","OC(=O)CCCC1=CC2=CC(=CC=C2[N]1[S](=O)(=O)C3=CC4=C(C=C3)N=CS4)Cl",4.676,4,0,6]
["S8771","IDF-11774","f8","L3000-37","in 10mM DMSO","HIF","Angiogenesis","IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.",368.51,"1429054-28-3",{"v":15,"d":"15.00"},{"v":40.7,"d":"40.70"},"<1","N/A","http://www.selleckchem.com/products/idf-11774.html","C23H32N2O2","Free Base","N/A","CN1CCN(CC1)C(=O)COC2=CC=C(C=C2)[C]34C[CH]5[CH2]C([CH2][CH](C5)C3)C4",3.446,2,0,4]
["S8772","LY 3200882","g8","L3000-37","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.",435.52,"1898283-02-7",{"v":87,"d":"87.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/ly3200882.html","C24H29N5O3","Free Base","N/A","CC(C)(O)C1=NC=CC(=C1)NC2=NC=CC(=C2)OC3=C[N](N=C3C4CCOCC4)C5CC5",3.363,5,1,7]
["S8773","TH34","h8","L3000-37","in 10mM DMSO","HDAC","Epigenetics","TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3.  In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM).",{"v":256.3,"d":"256.30"},"2196203-96-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/th34.html","C15H16N2O2","Free Base","N/A","CC1=CC=C(C=C1NCC2=CC=CC=C2)C(=O)NO",2.723,1,2,4]
["S8775","HS-1371","a9","L3000-37","in 10mM DMSO","RIP kinase","Apoptosis","HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.",384.47,"2158197-70-5",{"v":13,"d":"13.00"},33.81,"<1","N/A","http://www.selleckchem.com/products/hs-1371.html","C24H24N4O","Free Base","N/A","CC1=CC=C(OC2=CC=NC3=CC(=CC=C23)C4=C[N](N=C4)C5CCNCC5)C=C1",3.805,3,1,4]
["S8776","WM-1119","b9","L3000-37","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.",389.38,"2055397-28-7",{"v":78,"d":"78.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/wm-1119.html","C18H13F2N3O3S","Free Base","N/A","FC1=CC(=CC(=C1)C(=O)NN[S](=O)(=O)C2=CC=CC=C2F)C3=NC=CC=C3",2.781,4,2,5]
["S8777","Evobrutinib (M-2951)","c9","L3000-37","in 10mM DMSO","BTK","Protein Tyrosine Kinase","Evobrutinib (M-2951, MSC-2364447C) is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity.",429.51,"1415823-73-2",{"v":86,"d":"86.00"},200.23,"<1","N/A","http://www.selleckchem.com/products/evobrutinib.html","C25H27N5O2","Free Base","MSC-2364447C","NC1=C(C(=NC=N1)NCC2CCN(CC2)C(=O)C=C)C3=CC=C(OC4=CC=CC=C4)C=C3",3.916,4,2,7]
["S8778","UPGL00004","d9","L3000-37","in 10mM DMSO","Glutaminase","Proteases","UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.",534.66,"1890169-95-5",{"v":25,"d":"25.00"},46.76,"<1","N/A","http://www.selleck.cn/products/upgl00004.html","C25H26N8O2S2","free base","N/A","O=C(CC1=CC=CC=C1)NC2=NN=C(NC3CCN(CC3)C4=NN=C(NC(=O)CC5=CC=CC=C5)S4)S2",3.091,6,3,9]
["S8780","AZD3229","e9","L3000-37","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","AZD3229 is a potent, pan-Kit (c-Kit) mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant Kit (c-Kit) driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).",479.51,"2248003-60-1",{"v":96,"d":"96.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://www.selleck.cn/products/azd3229.html","C24H26FN7O3","free base","N/A","COCCOC1=CC(=C2C(=NC=NC2=C1)NC3=CC=C(NC(=O)C[N]4C=C(N=N4)C(C)C)C=C3)F",3.766,7,2,10]
["S8787","GSK'547","f9","L3000-37","in 10mM DMSO","RIP kinase","Apoptosis","GSK'547 is a highly selective and potent inhibitor of RIP1 (RIPK1) exhibiting a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963",396.39,"2226735-55-1",{"v":29,"d":"29.00"},73.16,"<1","N/A","http://www.selleck.cn/products/gsk547.html","C20H18F2N6O","free base","N/A","FC1=CC(=CC(=C1)F)C2CC=NN2C(=O)C3CCN(CC3)C4=NC=NC(=C4)C#N",2.776,4,0,3]
["S8788","CH7057288","g9","L3000-37","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.",569.67,"2095616-82-1",{"v":100,"d":"100.00"},175.54,"<1","N/A","http://www.selleck.cn/products/ch7057288.html","C32H31N3O5S","Free Base","N/A","CC1=CC(=CC(=N1)C#CC2=CC3=C(C=C2)C4=C(O3)C(C)(C)C5=CC(=CC=C5C4=O)N[S](C)(=O)=O)C(=O)NC(C)(C)C",5.151,6,2,6]
["S8789","SSE15206","h9","L3000-37","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.",371.45,"1370046-40-4",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://www.selleckchem.com/products/sse15206.html","C19H21N3O3S","Free Base","N/A","COC1=C(OC)C(=CC(=C1)C2CC(=NN2C(N)=S)C3=CC=CC=C3)OC",3.483,4,1,6]
["S8790","ML385","a10","L3000-37","in 10mM DMSO","Ferroptosis,Nrf2","Immunology & Inflammation","ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.",511.59,"846557-71-9",{"v":74,"d":"74.00"},144.65,"<1","N/A","http://www.selleckchem.com/products/ml385.html","C29H25N3O4S","Free Base","N/A","CC1=C(N=C(NC(=O)CC2=CC3=C(OCO3)C=C2)S1)C4=CC=C5N(CCC5=C4)C(=O)C6=C(C)C=CC=C6",5.058,5,1,5]
["S8791","Zanubrutinib (BGB-3111)","b10","L3000-37","in 10mM DMSO","BTK","Protein Tyrosine Kinase","Zanubrutinib (BGB-3111) is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR.",471.55,"1691249-45-2",{"v":94,"d":"94.00"},199.34,"<1","N/A","http://www.selleck.cn/products/zanubrutini-bgb-3111.html","C27H29N5O3","Free Base","N/A","NC(=O)C1=C2NCCC(C3CCN(CC3)C(=O)C=C)[N]2N=C1C4=CC=C(OC5=CC=CC=C5)C=C4",3.478,4,2,6]
["S8793","ULK-101","c10","L3000-37","in 10mM DMSO","Autophagy,ULK","Autophagy","ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.",460.45,"2443816-45-1",{"v":92,"d":"92.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/ulk-101.html","C22H16F4N4OS","Free Base","N/A","FC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CSC(=C4)C(=O)NC(C5CC5)C(F)(F)F",4.363,3,1,6]
["S8795","FDL169","d10","L3000-37","in 10mM DMSO","CFTR","Transmembrane Transporters","FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.",486.49,"1628416-28-3",{"v":33,"d":"33.00"},67.83,"<1","N/A","http://www.selleck.cn/products/fdl169.html","C27H23FN4O4","Free Base","N/A","CCOC1=CC=C2C(=C1)C(=O)N(CC(=O)N(C)C3=CC=C4N=C(C)OC4=C3)N=C2C5=CC(=CC=C5)F",{"v":3.87,"d":"3.870"},6,0,6]
["S8801","CC-90003","e10","L3000-37","in 10mM DMSO","ERK","MAPK","CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay.",458.44,"1621999-82-3",{"v":92,"d":"92.00"},200.68,"<1","N/A","http://www.selleckchem.com/products/cc-90003.html","C22H21F3N6O2","Free Base","N/A","COC1=CC(=C(C)C=N1)NC2=NC(=C(C=N2)C(F)(F)F)NC3=C(NC(=O)C=C)C=C(C)C=C3",5.316,5,3,8]
["S8803","MK-3903","f10","L3000-37","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.",{"v":454.9,"d":"454.90"},"1219737-12-8",{"v":91,"d":"91.00"},200.04,"<1","N/A","http://www.selleckchem.com/products/mk-3903.html","C27H19ClN2O3","Free Base","N/A","CC1=CC=C(OC2=NC3=CC(=C(C=C3[NH]2)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C=C1C(O)=O",7.264,3,1,5]
["S8807","PFK158","g10","L3000-37","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.",328.29,"1462249-75-7",{"v":14,"d":"14.00"},42.65,"<1","N/A","http://www.selleck.cn/products/pfk158.html","C18H11F3N2O","free base","N/A","FC(F)(F)C1=CC=C2C=CC(=NC2=C1)\\C=C\\C(=O)C3=CC=NC=C3",4.108,3,0,4]
["S8808","DC661","h10","L3000-37","in 10mM DMSO","Apoptosis related,Autophagy","Autophagy","DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis.",552.58,"1872387-43-3",{"v":62,"d":"62.00"},{"v":112.2,"d":"112.20"},"<1","N/A","http://www.selleck.cn/products/dc661.html","C31H39Cl2N5","free base","N/A","CN(CCCCCCNC1=CC=NC2=CC(=CC=C12)Cl)CCCCCCNC3=CC=NC4=C3C=CC(=C4)Cl",8.045,2,2,16]
["S8810","SPHINX31","a11","L3000-37","in 10mM DMSO","Serine/threonin kinase","Protein Tyrosine Kinase","SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold).",507.51,"1818389-84-2",{"v":25,"d":"25.00"},49.26,"<1","N/A","http://www.selleck.cn/products/sphinx31.html","C27H24F3N5O2","free base","N/A","FC(F)(F)C1=CC(=C(C=C1)N2CCN(CC2)CC3=CC=CC=N3)NC(=O)C4=CC=C(O4)C5=CC=NC=C5",4.378,4,1,7]
["S8813","LIT-927","b11","L3000-37","in 10mM DMSO","CXCR","Immunology & Inflammation","LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.",328.75,"2172879-52-4",{"v":66,"d":"66.00"},200.76,"<1","N/A","http://www.selleckchem.com/products/lit-927.html","C17H13ClN2O3","Free Base","N/A","COC1=CC(=CC=C1O)C2=CC(=NC(=O)N2)C3=CC=C(Cl)C=C3",3.599,3,2,3]
["S8817","Almonertinib (HS-10296)","c11","L3000-37","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Almonertinib (Aumolertinib, HS-10296, Ameile) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.",525.64,"1899921-05-1",{"v":100,"d":"100.00"},190.24,"<1","N/A","http://www.selleck.cn/products/hs-10296.html","C30H35N7O2","Free Base","Aumolertinib, Ameile","COC1=C(NC2=NC(=CC=N2)C3=C[N](C4CC4)C5=C3C=CC=C5)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",{"v":5.16,"d":"5.160"},4,2,11]
["S8818","V-9302","d11","L3000-37","in 10mM DMSO","Amino acid transporter","Transmembrane Transporters","V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.",538.68,"1855871-76-9",{"v":100,"d":"100.00"},185.64,{"v":100,"d":"100.00"},185.64,"http://www.selleck.cn/products/v-9302.html","C34H38N2O4","free base","N/A","CC1=CC(=CC=C1)COC2=C(CN(CCC(N)C(O)=O)CC3=CC=CC=C3OCC4=CC=CC(=C4)C)C=CC=C2",3.409,3,1,14]
["S8826","BAY-293","e11","L3000-37","in 10mM DMSO","Ras","Cell Cycle","BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM.",448.58,"2244904-70-7",{"v":90,"d":"90.00"},200.63,"<1","N/A","http://www.selleck.cn/products/bay-293.html","C25H28N4O2S","free base","N/A","CNCC1=C(C=CC=C1)C2=CSC(=C2)C(C)NC3=NC(=NC4=CC(=C(OC)C=C34)OC)C",4.522,4,2,8]
["S8840","SEL120 (SEL120-34A) hydrochloride","f11","L3000-37","in 10mM DMSO","CDK","Cell Cycle","SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.",{"v":450.6,"d":"450.60"},"1609452-30-3",{"v":11,"d":"11.00"},24.41,{"v":90,"d":"90.00"},199.73,"http://www.selleck.cn/products/sel120.html","C15H18Br2N4.xHCl","hydrochloride","SEL120-34","Cl.CC1=C2N=C(N3CCNCC3)[N]4CCCC(=C24)C(=C1Br)Br",4.572,1,1,1]
["S8842","BAY-218","g11","L3000-37","in 10mM DMSO","AhR","Metabolism","BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.",401.82,"2162982-11-6",{"v":80,"d":"80.00"},199.09,"<1","N/A","http://www.selleck.cn/products/bay-218.html","C20H17ClFN3O3","free base","N/A","CC(CO)NC(=O)C1=CC(=NN(C2=CC=CC(=C2)F)C1=O)C3=CC=C(Cl)C=C3",3.106,3,2,5]
["S8846","compound 3i (666-15)","h11","L3000-37","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Compound 3i (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription (IC50 = 0.081 ± 0.04 μM) and also potently inhibits cancer cell growth without harming normal cells.",620.52,"1433286-70-4",{"v":100,"d":"100.00"},161.16,"<1","N/A","http://www.selleck.cn/products/compound-3i.html","C33H31Cl2N3O5","Free Base","N/A","Cl.NCCCOC1=C(C=C2C=CC=CC2=C1)C(=O)NCCOC3=CC4=CC=CC=C4C=C3C(=O)NC5=CC=C(Cl)C=C5O",5.293,4,4,11]
["S8854","JNJ-38877618(OMO-1)","a2","L3000-38","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).",374.35,"943540-74-7",{"v":10,"d":"10.00"},26.71,"<1","N/A","http://www.selleck.cn/products/jnj-38877618.html","C20H12F2N6","free base","N/A","FC(F)(C1=CC2=C(C=C1)N=CC=C2)C3=NN=C4C=CC(=N[N]34)C5=CC=NC=C5",3.252,5,0,3]
["S8859","BMS-1166","b2","L3000-38","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.",641.11,"1818314-88-3",{"v":100,"d":"100.00"},155.98,"<1","N/A","http://www.selleck.cn/products/bms-1166.html","C36H33ClN2O7","free base","N/A","CC1=C(C=CC=C1COC2=CC(=C(CN3CC(O)CC3C(O)=O)C=C2Cl)OCC4=CC(=CC=C4)C#N)C5=CC6=C(OCCO6)C=C5",3.323,5,1,10]
["S8864","ZT-12-037-01","c2","L3000-38","in 10mM DMSO","Serine/threonin kinase","Apoptosis","ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.",{"v":385.5,"d":"385.50"},"2328073-61-4",{"v":41,"d":"41.00"},106.36,"<1","N/A","http://www.selleck.cn/products/zt-12-037-01.html","C21H31N5O2","free base","N/A","COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)C(C)C)NC4CC4",3.359,4,2,7]
["S8867","Bentamapimod (AS602801)","d2","L3000-38","in 10mM DMSO","JNK","MAPK","Bentamapimod (AS602801) is a novel, orally active JNK inhibitor with IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively.",457.55,"848344-36-5",{"v":24,"d":"24.00"},52.45,"<1","N/A","http://www.selleck.cn/products/bentamapimod.html","C25H23N5O2S","free base","N/A","N#CC(C1=NC2=CC=CC=C2S1)C3=NC(=NC=C3)OCC4=CC=C(CN5CCOCC5)C=C4",4.228,5,0,7]
["S8872","GSK8612","e2","L3000-38","in 10mM DMSO","TBK1","Immunology & Inflammation","GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified.",520.33,"2361659-62-1",{"v":100,"d":"100.00"},192.19,"<1","N/A","http://www.selleck.cn/products/gsk8612.html","C17H17BrF3N7O2S","free base","N/A","CC1=N[N](CC(F)(F)F)C=C1NC2=NC=C(Br)C(=N2)NCC3=CC=C(C=C3)[S](N)(=O)=O",3.447,5,3,8]
["S9007","2'-deoxyguanosine","f2","L3000-38","in 10mM DMSO","Others","Others","2'-deoxyguanosine is a kind of purine nucleoside.",267.24,"961-07-9",{"v":53,"d":"53.00"},198.32,"N/A","N/A","https://www.selleckchem.com/products/2-deoxyguanosine-monohydrate.html","C10H13N5O4","free base","2'-Deoxy-D-guanosine","NC1=NC2=C(N=C[N]2C3CC(O)C(CO)O3)C(=O)N1",-1.613,4,4,2]
["S9009","23-Hydroxybetulinic acid","g2","L3000-38","in 10mM DMSO","Others","Others","23-Hydroxybetulinic acid is a natural lupanetype pentacyclic triterpene isolated from the root of traditional Chinese herb Pulsatilla chinensis with remarkable antineoplastic activities.",{"v":472.7,"d":"472.70"},"85999-40-2",{"v":94,"d":"94.00"},198.86,"N/A","N/A","https://www.selleckchem.com/products/23-hydroxybetulinic-acid.html","C30H48O4","free base","Anemosapoginin","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C12)C(O)=O",5.456,1,2,3]
["S9017","Columbianadin","h2","L3000-38","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Columbianadin (Zosimin, 2-Butenoic acid), a natural coumarin from Angelica decursiva, is known to have various biological activities including calcium-channel blocking activity, cytotoxic activity against various cancer cell lines, analgesic activities, intestinal absorption and transportation, anti-inflammatory and anti-cancer effects.",328.36,"5058-13-9",{"v":10,"d":"10.00"},30.45,"N/A","N/A","https://www.selleckchem.com/products/columbianadin.html","C19H20O5","free base","Zosimin, 2-Butenoic acid","C\\C=C(C)/C(=O)OC(C)(C)C1CC2=C(O1)C=CC3=C2OC(=O)C=C3",3.955,5,0,4]
["S9018","Luteoloside","a3","L3000-38","in 10mM DMSO","3C-Like Protease,ADC Cytotoxin,Enterovirus","Microbiology","Luteoloside (Cynaroside, Luteolin 7-β-D-Glucopyranoside) is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM.",448.38,"5373-11-5",{"v":10,"d":"10.00"},{"v":22.3,"d":"22.30"},"N/A","N/A","https://www.selleckchem.com/products/luteoloside.html","C21H20O11","free base","Cynaroside, Luteolin 7-β-D-Glucopyranoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",0.238,4,7,4]
["S9021","(20R)Ginsenoside Rg3","b3","L3000-38","in 10mM DMSO","ROS","Immunology & Inflammation","(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.",785.01,"38243-03-7",{"v":10,"d":"10.00"},12.74,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rg3.html","C42H72O13","free base","OG15964","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["S9022","20S-Ginsenoside Rg3","c3","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.",785.01,"14197-60-5",{"v":10,"d":"10.00"},12.74,"N/A","N/A","https://www.selleckchem.com/products/20s-ginsenoside-rg3.html","C42H72O13","free base","3b-[2-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]-dammar-24-ene-12b, 20 diol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["S9023","20S-Ginsenoside Rh2","d3","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.",622.87,"78214-33-2",{"v":10,"d":"10.00"},16.05,"N/A","N/A","https://www.selleckchem.com/products/20s-ginsenoside-rh2.html","C36H62O8","free base","(3b, 12b)-12, 20-Dihydroxydammar-24-en-3-yl b-D-glucopyranoside; Δ20(22)-Ginsenoside Rg6; (20E)-Ginsenoside F4","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5O)C(C)(C)C4CCC23C",4.042,2,5,7]
["S9031","Gambogenic acid","e3","L3000-38","in 10mM DMSO","EZH1/2,FGFR","Angiogenesis","Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.",630.77,"173932-75-7",{"v":10,"d":"10.00"},15.85,"N/A","N/A","https://www.selleckchem.com/products/gambogenic-acid.html","C38H46O8","free base","N/A","CC(C)=CCC/C(C)=C/CC1=C(O)C2=C(OC34C5CC(C=C3C2=O)C(=O)C4(C\\C=C(\\C)C(O)=O)OC5(C)C)C(=C1O)CC=C(C)C",7.717,5,2,10]
["S9032","Sanguinarine","f3","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.",332.33,"2447-54-3",{"v":44,"d":"44.00"},{"v":132.4,"d":"132.40"},"N/A","N/A","https://www.selleckchem.com/products/sanguinarine.html","C20H14NO4","free base","Pseudochelerythrine, Sanguinarin, Sanguinarium","C[N+]1=CC2=C3OCOC3=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4",3.987,4,0,0]
["S9036","(20R)Ginsenoside Rh2","g3","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","(20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.,",622.87,"112246-15-8",{"v":100,"d":"100.00"},160.55,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rh2.html","C36H62O8","free base","FG73845","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5O)C(C)(C)C4CCC23C",4.042,2,5,7]
["S9038","Calycosin","h3","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Calycosin (3'-Hydroxyformononetin), an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects.",284.26,"20575-57-9",{"v":57,"d":"57.00"},200.52,"N/A","N/A","https://www.selleckchem.com/products/calycosin.html","C16H12O5","free base","3'-Hydroxyformononetin","COC1=C(O)C=C(C=C1)C2=COC3=C(C=CC(=C3)O)C2=O",2.366,3,2,2]
["S9040","Maslinic acid","a4","L3000-38","in 10mM DMSO","NF-κB","NF-κB","Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.",{"v":472.7,"d":"472.70"},"4373-41-5",{"v":10,"d":"10.00"},21.16,"N/A","N/A","https://www.selleckchem.com/products/maslinic-acid.html","C30H48O4","free base","Crategolic Acid, 2α-Hydroxyoleanoic Acid","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",{"v":5.48,"d":"5.480"},1,2,1]
["S9041","Corosolic acid","b4","L3000-38","in 10mM DMSO","NF-κB","NF-κB","Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells.",{"v":472.7,"d":"472.70"},"4547-24-4",{"v":95,"d":"95.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/corosolic-acid.html","C30H48O4","free base","Glucosol, Colosic acid, 2α-Hydroxyursolic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",5.525,1,2,1]
["S9042","Wedelolactone","c4","L3000-38","in 10mM DMSO","Caspase,IκB/IKK","NF-κB","Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.",314.25,"524-12-9",{"v":63,"d":"63.00"},200.48,"N/A","N/A","https://www.selleckchem.com/products/wedelolactone.html","C16H10O7","free base","FW73945","COC1=CC2=C(C(=C1)O)C3=C(C(=O)O2)C4=C(O3)C=C(O)C(=C4)O",2.803,4,3,1]
["S9043","6-Shogaol","d4","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.,",276.37,"555-66-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/6-shogaol.html","C17H24O3","free base","FS42771","CCCCC/C=C/C(=O)CCC1=CC=C(O)C(=C1)OC",4.717,2,1,9]
["S9046","Berberine","e4","L3000-38","in 10mM DMSO","Bacterial","Microbiology","Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.",336.36,"2086-83-1",{"v":45,"d":"45.00"},133.78,"N/A","N/A","https://www.selleckchem.com/products/berberine.html","C20H18NO4","free base","Umbellatine","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4",3.962,4,0,2]
["S9047","Leonurine Hydrochloride","f4","L3000-38","in 10mM DMSO","Others","Others","Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.",347.79,"24735-18-0",{"v":70,"d":"70.00"},201.27,"N/A","N/A","https://www.selleckchem.com/products/leonurine-hydrochloride.html","C14H22ClN3O5","free base","SCM-198 HCl","Cl.COC1=C(O)C(=CC(=C1)C(=O)OCCCCNC(N)=N)OC",1.472,4,3,10]
["S9048","(+)-Gallocatechin","g4","L3000-38","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","(+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant.",306.27,"970-73-0",{"v":10,"d":"10.00"},32.65,"N/A","N/A","https://www.selleckchem.com/products/gallocatechin.html","C15H14O7","free base","(2S, 3R)-3, 4-Dihydro-2-(3, 4, 5-trihydroxyphenyl)-2H-1-benzopyran-3, 5, 7-triol; (2S-trans)-3, 4-Dihydro-2-(3, 4, 5-trihydroxyphenyl)-2H-1-benzopyran-3, 5, 7-triol; (-)-Gallocatechol; Gallocatechin","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S9052","Auraptene","h4","L3000-38","in 10mM DMSO","Immunology & Inflammation related,Interleukins,MMP","Immunology & Inflammation","Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).",298.38,"495-02-3",{"v":10,"d":"10.00"},33.51,"N/A","N/A","https://www.selleckchem.com/products/auraptene.html","C19H22O3","free base","7-geranyloxycoumarin","CC(C)=CCC/C(C)=C/COC1=CC2=C(C=CC(=O)O2)C=C1",5.175,3,0,6]
["S9057","Sinigrin","a5","L3000-38","in 10mM DMSO","Fungal,Immunology & Inflammation related","Microbiology","Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.",397.46,"3952-98-5",{"v":10,"d":"10.00"},25.16,"N/A","N/A","https://www.selleckchem.com/products/sinigrin.html","C10H16KNO9S2","free base","Allylglucosinolate, 2-Propenylglucosinolate","[K+].OCC1OC(S\\C(CC=C)=N\\O[S]([O-])(=O)=O)C(O)C(O)C1O",-3.447,3,4,7]
["S9058","Gallocatechin gallate","b5","L3000-38","in 10mM DMSO","Others","Others","Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds.",458.37,"4233-96-9",{"v":10,"d":"10.00"},21.82,"N/A","N/A","https://www.selleckchem.com/products/gallocatechin-gallate.html","C22H18O11","free base","FG40482","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S9061","Hydroxy safflor yellow A","c5","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.",612.53,"78281-02-4",{"v":10,"d":"10.00"},16.33,"N/A","N/A","https://www.selleckchem.com/products/hydroxy-safflor-yellow-a.html","C27H32O16","free base","2, 4-Di-b-D-glucopyranosyl-3, 4, 5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)-2, 5-cyclohexadien-1-one; Safflomin A","OCC1OC(C(O)C(O)C1O)C2=C(O)C(O)(C3OC(CO)C(O)C(O)C3O)C(=C(C(=O)\\C=C\\C4=CC=C(O)C=C4)C2=O)O",-4.096,4,11,7]
["S9063","Harringtonine","d5","L3000-38","in 10mM DMSO","Antiviral","Microbiology","Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.",531.59,"26833-85-2",{"v":10,"d":"10.00"},18.81,"N/A","N/A","https://www.selleckchem.com/products/harringtonine.html","C28H37NO9","free base","FH15975","COC(=O)CC(O)(CCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",1.961,7,0,10]
["S9065","Songorine","e5","L3000-38","in 10mM DMSO","ADC Cytotoxin,GABA Receptor","Neuronal Signaling","Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.",357.49,"509-24-0",{"v":10,"d":"10.00"},27.97,"N/A","N/A","https://www.selleckchem.com/products/songorine.html","C22H31NO3","free base","FS145273","CCN1CC2(C)CCC(O)C34C1C(CC23)C56CC(C(=C)C5O)C(=O)CC46",1.035,1,2,1]
["S9066","Specnuezhenide","f5","L3000-38","in 10mM DMSO","Others","Others","Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects.",686.66,"449733-84-0",{"v":10,"d":"10.00"},14.56,"N/A","N/A","https://www.selleckchem.com/products/specnuezhenide.html","C31H42O17","free base","Nuezhenide","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C/C)C1CC(=O)OCC3OC(OCCC4=CC=C(O)C=C4)C(O)C(O)C3O",-1.339,9,8,14]
["S9070","Isoxanthohumol","g5","L3000-38","in 10mM DMSO","HSV","Microbiology","Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).",{"v":354.4,"d":"354.40"},"70872-29-6",{"v":10,"d":"10.00"},28.22,"N/A","N/A","https://www.selleckchem.com/products/isoxanthohumol.html","C21H22O5","free base","FI45719","COC1=CC(=C(CC=C(C)C)C2=C1C(=O)CC(O2)C3=CC=C(O)C=C3)O",4.456,3,2,4]
["S9072","Sweroside","h5","L3000-38","in 10mM DMSO","Fungal,Immunology & Inflammation related","Microbiology","Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.",358.34,"14215-86-2",{"v":10,"d":"10.00"},27.91,"N/A","N/A","https://www.selleckchem.com/products/sweroside.html","C16H22O9","free base","FS73846","OCC1OC(OC2OC=C3C(CCOC3=O)C2C=C)C(O)C(O)C1O",-1.408,5,4,4]
["S9073","Lithospermoside","a6","L3000-38","in 10mM DMSO","Others","Others","Lithospermoside (Griffonin), extracted from the roots of Lithospermum purpurocaeruleum and L.officinale (Borginaceae), and Thalictrum rugosum and T. dasycarpum (Ranunculaceae), has anti-oxidant, anti-tumor promoting activities.",{"v":329.3,"d":"329.30"},"63492-69-3",{"v":10,"d":"10.00"},30.37,"N/A","N/A","https://www.selleckchem.com/products/lithospermoside.html","C14H19NO8","free base","Griffonin","OCC1OC(OC\\2C(O)C(O)C=CC2=C/C#N)C(O)C(O)C1O",-2.505,2,6,3]
["S9075","Mulberroside A","b6","L3000-38","in 10mM DMSO","Caspase,ERK,Interleukins,JNK,NF-κB,p38 MAPK,TNF-alpha","Immunology & Inflammation","Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. Mulberroside A decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38.",568.52,"102841-42-9",{"v":10,"d":"10.00"},17.59,"N/A","N/A","https://www.selleckchem.com/products/mulberroside-a.html","C26H32O14","free base","FM74212","OCC1OC(OC2=CC=C(/C=C/C3=CC(=CC(=C3)O)OC4OC(CO)C(O)C(O)C4O)C(=C2)O)C(O)C(O)C1O",-1.012,4,10,8]
["S9078","Epigoitrin","c6","L3000-38","in 10mM DMSO","Antiviral","Microbiology","Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.",129.18,"1072-93-1",4.89,37.85,"N/A","N/A","https://www.selleckchem.com/products/epigoitrin.html","C5H7NOS","free base","Goitrin, BA-51-090278","C=CC1CNC(=S)O1",1.574,1,1,1]
["S9080","Anhydroicaritin","d6","L3000-38","in 10mM DMSO","Others","Apoptosis","Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.",368.38,"118525-40-9",{"v":10,"d":"10.00"},27.15,"N/A","N/A","https://www.selleckchem.com/products/anhydroicaritin.html","C21H20O6","free base","Cycloicaritin","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C(=C3O2)CC=C(C)C",3.954,3,3,4]
["S9082","Manninotriose","e6","L3000-38","in 10mM DMSO","Others","Others","Manninotriose, found in many foods, is a novel and important player in the RFO metabolism of red dead deadnettle.",504.44,"13382-86-0",{"v":10,"d":"10.00"},19.82,"N/A","N/A","https://www.selleckchem.com/products/manninotriose.html","C18H32O16","free base","N/A","OCC1OC(OCC2OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C2O)C(O)C(O)C1O",-6.285,5,11,11]
["S9083","Rhapontin","f6","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity.",420.41,"155-58-8",{"v":10,"d":"10.00"},23.79,"N/A","N/A","https://www.selleckchem.com/products/rhapontin.html","C21H24O9","free base","Ponticin, Rhaponticin, Rhapontigenin glucoside","COC1=C(O)C=C(C=C1)/C=C/C2=CC(=CC(=C2)O)OC3OC(CO)C(O)C(O)C3O",1.144,3,6,6]
["S9084","Rhoifolin","g6","L3000-38","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.",578.52,"17306-46-6",{"v":10,"d":"10.00"},17.29,"N/A","N/A","https://www.selleckchem.com/products/rhoifolin.html","C27H30O14","free base","Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC4=C(C(=C3)O)C(=O)C=C(O4)C5=CC=C(O)C=C5)C(O)C(O)C1O",-0.378,6,8,6]
["S9085","Corynoline","h6","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.",{"v":367.4,"d":"367.40"},"18797-79-0",{"v":10,"d":"10.00"},27.22,"N/A","N/A","https://www.selleckchem.com/products/corynoline.html","C21H21NO5","free base","N/A","CN1CC2=C(C=CC3=C2OCO3)C4(C)C(O)CC5=C(C=C6OCOC6=C5)C14",2.732,4,1,0]
["S9088","Calycosin-7-O-beta-D-glucoside","a7","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.",{"v":446.4,"d":"446.40"},"20633-67-4",{"v":10,"d":"10.00"},{"v":22.4,"d":"22.40"},"N/A","N/A","https://www.selleckchem.com/products/calycosin-7-o-beta-d-glucoside.html","C22H22O10","free base","N/A","COC1=C(O)C=C(C=C1)C2=COC3=C(C=CC(=C3)OC4OC(CO)C(O)C(O)C4O)C2=O",0.436,5,5,5]
["S9090","Corilagin","b7","L3000-38","in 10mM DMSO","Immunology & Inflammation related,TNF-alpha","Apoptosis","Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.",634.45,"23094-69-1",{"v":10,"d":"10.00"},15.76,"N/A","N/A","https://www.selleckchem.com/products/corilagin.html","C27H22O18","free base","N/A","OC1C2COC(=O)C3=CC(=C(O)C(=C3C4=C(C=C(O)C(=C4O)O)C(=O)OC1C(O)C(O2)OC(=O)C5=CC(=C(O)C(=C5)O)O)O)O",1.127,7,11,3]
["S9091","10-Gingerol","c7","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.",350.49,"23513-15-7",{"v":10,"d":"10.00"},28.53,"N/A","N/A","https://www.selleckchem.com/products/10-gingerol.html","C21H34O4","free base","N/A","CCCCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",5.463,2,2,14]
["S9093","Nardosinone","d7","L3000-38","in 10mM DMSO","Others","Others","Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities.",250.33,"23720-80-1",{"v":50,"d":"50.00"},199.73,"N/A","N/A","https://www.selleckchem.com/products/nardosinone.html","C15H22O3","free base","N/A","CC1CCC=C2C(=O)CC3OOC(C)(C)C3C12C",{"v":2.18,"d":"2.180"},3,0,0]
["S9094","Pogostone","e7","L3000-38","in 10mM DMSO","Anti-infection","Microbiology","Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.",224.25,"23800-56-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/pogostone.html","C12H16O4","free base","N/A","CC(C)CCC(=O)C1=C(O)C=C(C)OC1=O",1.821,3,1,4]
["S9095","Senegenin","f7","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.",537.13,"2469-34-3",{"v":10,"d":"10.00"},18.62,"N/A","N/A","https://www.selleckchem.com/products/senegenin.html","C30H45ClO6","free base","Tenuigenin","CC1(C)CCC2(CCC3=C(C(CCl)CC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O",{"v":4.91,"d":"4.910"},2,2,3]
["S9097","Alisol B Acetate","g7","L3000-38","in 10mM DMSO","Caspase","Apoptosis","Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.",514.74,"26575-95-1",{"v":100,"d":"100.00"},194.27,"N/A","N/A","https://www.selleckchem.com/products/alisol-b-acetate.html","C32H50O5","free base","N/A","CC(CC(OC(C)=O)C1OC1(C)C)C2=C3CC(O)C4C5(C)CCC(=O)C(C)(C)C5CCC4(C)C3(C)CC2",5.161,4,1,6]
["S9100","Fraxinellone","h7","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.",232.27,"28808-62-0",{"v":46,"d":"46.00"},198.04,"N/A","N/A","https://www.selleckchem.com/products/fraxinellone.html","C14H16O3","free base","N/A","CC1=C2C(=O)OC(C3=COC=C3)C2(C)CCC1",2.995,3,0,1]
["S9101","Ingenol","a8","L3000-38","in 10mM DMSO","PKC","Cytoskeletal Signaling","Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.",348.43,"30220-46-3",{"v":69,"d":"69.00"},198.03,"N/A","N/A","https://www.selleckchem.com/products/ingenol.html","C20H28O5","free base","N/A","CC1CC2C(C3C=C(CO)C(O)C4(O)C(O)C(=CC14C3=O)C)C2(C)C",0.543,1,3,1]
["S9106","Eleutheroside E","b8","L3000-38","in 10mM DMSO","Immunology & Inflammation related,NF-κB","NF-κB","Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.",742.72,"39432-56-9",{"v":10,"d":"10.00"},13.46,"N/A","N/A","https://www.selleckchem.com/products/eleutheroside-e.html","C34H46O18","free base","N/A","COC1=C(OC2OC(CO)C(O)C(O)C2O)C(=CC(=C1)C3OCC4C3COC4C5=CC(=C(OC6OC(CO)C(O)C(O)C6O)C(=C5)OC)OC)OC",-1.709,10,8,12]
["S9107","Glycitein","c8","L3000-38","in 10mM DMSO","ROS","Immunology & Inflammation","Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.",284.26,"40957-83-3",{"v":10,"d":"10.00"},35.18,"N/A","N/A","https://www.selleckchem.com/products/glycitein.html","C16H12O5","free base","N/A","COC1=CC2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O",2.366,3,2,2]
["S9108","Timosaponin A3","d8","L3000-38","in 10mM DMSO","Others","Others","Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity.",740.92,"41059-79-4",{"v":100,"d":"100.00"},134.97,"N/A","N/A","https://www.selleckchem.com/products/timosaponin-a3.html","C39H64O13","free base","Filiferin B, AneMarsaponin A3","CC1CCC2(OC1)OC3CC4C5CCC6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O",{"v":1.39,"d":"1.390"},6,7,6]
["S9112","Kaempferitrin","e8","L3000-38","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.",578.52,"482-38-2",{"v":100,"d":"100.00"},172.86,"N/A","N/A","https://www.selleckchem.com/products/kaempferitrin.html","C27H30O14","free base","Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside","CC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(O)C=C4)OC5OC(C)C(O)C(O)C5O)C(O)C(O)C1O",-0.211,6,8,5]
["S9113","Ononin","f8","L3000-38","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.",{"v":430.4,"d":"430.40"},"486-62-4",{"v":86,"d":"86.00"},199.81,"N/A","N/A","https://www.selleckchem.com/products/ononin.html","C22H22O9","free base","Formononetin glucoside, Formononetin 7-O-glucoside","COC1=CC=C(C=C1)C2=COC3=C(C=CC(=C3)OC4OC(CO)C(O)C(O)C4O)C2=O",0.678,5,4,5]
["S9114","Polyphyllin I","g8","L3000-38","in 10mM DMSO","JNK","MAPK","Polyphyllin I, a small molecular monomer extracted from Rhizoma of Paris polyphyllin, is used in the treatment of infectious disease and cancer. Polyphyllin I inhibits proliferation and induces apoptotic cell death in U251 cells. Polyphyllin I is an activator of the JNK signaling pathway with a potential anti-glioma effect.",855.02,"50773-41-6",{"v":100,"d":"100.00"},116.96,"N/A","N/A","https://www.selleckchem.com/products/polyphyllin-i.html","C44H70O16","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(CO)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",0.792,8,8,8]
["S9115","Wogonoside","h8","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.",460.39,"51059-44-0",{"v":38,"d":"38.00"},82.54,"N/A","N/A","https://www.selleckchem.com/products/wogonoside.html","C22H20O11","free base","Oroxindin, Wogonin 7-O-glucuronide, Glychionide B","COC1=C(OC2OC(C(O)C(O)C2O)C(O)=O)C=C(O)C3=C1OC(=CC3=O)C4=CC=CC=C4",0.833,6,4,5]
["S9120","Scutellarein","a9","L3000-38","in 10mM DMSO","Antiviral,Immunology & Inflammation related","Immunology & Inflammation","Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities",286.24,"529-53-3",{"v":57,"d":"57.00"},199.14,"N/A","N/A","https://www.selleckchem.com/products/scutellarein.html","C15H10O6","free base/salt","6-Hydroxyapigenin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)O",2.168,2,4,1]
["S9122","Tectorigenin","b9","L3000-38","in 10mM DMSO","Bacterial,Estrogen/progestogen Receptor","Microbiology","Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunbergiana Benth, Belamcanda chinensis, and Iris unguicularis. It has been reported to exert pharmacological actions, including antitumor and antibacterial effects, free radical neutralization, and selective estrogen receptor modulation.",300.26,"548-77-6",{"v":60,"d":"60.00"},199.82,"N/A","N/A","https://www.selleckchem.com/products/tectorigenin.html","C16H12O6","free base","N/A","COC1=C(O)C2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O",2.124,3,3,2]
["S9125","Apigetrin","c9","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.",432.38,"578-74-5",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/apigetrin.html","C21H20O10","free base","Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9126","Schizandrol B","d9","L3000-38","in 10mM DMSO","Others","Others","Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.",416.46,"58546-54-6",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/schizandrol-b.html","C23H28O7","free base","Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)(O)C2)C=C4OCOC4=C3OC",3.851,6,0,4]
["S9127","Carnosol","e9","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.",330.42,"5957-80-2",{"v":66,"d":"66.00"},199.75,"N/A","N/A","https://www.selleckchem.com/products/carnosol.html","C20H26O4","free base","N/A","CC(C)C1=CC2=C(C(=C1O)O)C34CCCC(C)(C)C3CC2OC4=O",4.387,2,2,1]
["S9132","Harpagide","f9","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.",364.35,"6926-08-5",{"v":72,"d":"72.00"},197.61,"N/A","N/A","https://www.selleckchem.com/products/harpagide.html","C15H24O10","free base","N/A","CC1(O)CC(O)C2(O)C=COC(OC3OC(CO)C(O)C(O)C3O)C12",-3.902,3,5,3]
["S9133","Chicoric acid","g9","L3000-38","in 10mM DMSO","Others","Others","Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects.",474.37,"70831-56-0",{"v":94,"d":"94.00"},198.16,"N/A","N/A","https://www.selleckchem.com/products/chicoric-acid.html","C22H18O12","free base","Dicaffeoyltartaric acid","OC(=O)C(OC(=O)\\C=C\\C1=CC(=C(O)C=C1)O)C(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C(O)=O",{"v":2.39,"d":"2.390"},6,4,11]
["S9135","Artemisic acid","h9","L3000-38","in 10mM DMSO","Bacterial","Microbiology","Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.",234.33,"80286-58-4",{"v":46,"d":"46.00"},{"v":196.3,"d":"196.30"},"N/A","N/A","https://www.selleckchem.com/products/artemisic-acid.html","C15H22O2","free base","Artemisinic acid","CC1CCC(C2C=C(C)CCC12)C(=C)C(O)=O",3.942,1,0,2]
["S9136","Neochlorogenic acid","a10","L3000-38","in 10mM DMSO","Antiviral,Bacterial,Immunology & Inflammation related","Immunology & Inflammation","Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.",354.31,"906-33-2",{"v":70,"d":"70.00"},197.57,"N/A","N/A","https://www.selleckchem.com/products/neochlorogenic-acid.html","C16H18O9","free base","Neochlorogenate, 5-O-Caffeoylquinic acid","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S9137","Erianin","b10","L3000-38","in 10mM DMSO","IDO/TDO","Metabolism","Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis.",318.36,"95041-90-0",{"v":63,"d":"63.00"},197.89,"N/A","N/A","https://www.selleckchem.com/products/erianin.html","C18H22O5","free base","N/A","COC1=C(O)C=C(CCC2=CC(=C(OC)C(=C2)OC)OC)C=C1",3.953,4,1,7]
["S9140","Pulegone","c10","L3000-38","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient.pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations.",152.23,"89-82-7","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/pulegone.html","C10H16O","free base","N/A","CC1CCC(=C(C)C)C(=O)C1",2.891,1,0,0]
["S9141","Berbamine","d10","L3000-38","in 10mM DMSO","Apoptosis related,Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",608.72,"478-61-5",{"v":100,"d":"100.00"},164.28,"N/A","N/A","https://www.selleckchem.com/products/berbamine.html","C37H40N2O6","free base","BA, BBM","COC1=C2OC3=C4C(CC5=CC=C(O)C(=C5)OC6=CC=C(CC7N(C)CCC(=C1)C7=C2)C=C6)N(C)CCC4=CC(=C3OC)OC",6.992,5,1,3]
["S9148","Peiminine","e10","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.",429.64,"18059-10-4",{"v":85.9,"d":"85.90"},199.94,"N/A","N/A","https://www.selleckchem.com/products/peiminine.html","C27H43NO3","free base","Verticinone, Zhebeinone, Raddeanine","CC1CCC2N(C1)CC3C4CC5C(CC(=O)C6CC(O)CCC56C)C4CCC3C2(C)O",3.354,1,1,0]
["S9150","Daurisoline","f10","L3000-38","in 10mM DMSO","Autophagy","Autophagy","Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.",610.74,"70553-76-3",{"v":64,"d":"64.00"},104.79,"N/A","N/A","https://www.selleckchem.com/products/daurisoline.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1O)C(CC3=CC(=C(O)C=C3)OC4=CC=C(CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C=C4)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9153","Betulinicaldehyde","g10","L3000-38","in 10mM DMSO","Others","Others","Betulinicaldehyde (Betulinal, Betunal),  isolated from the bark of tectona grandis., is an anti-tumor agent.",{"v":440.7,"d":"440.70"},"13159-28-9",{"v":10,"d":"10.00"},22.69,"N/A","N/A","https://www.selleckchem.com/products/betulinicaldehyde.html","C30H48O2","free base","Betulinal, Betunal","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C=O",6.568,1,1,2]
["S9154","Chelidonine","h10","L3000-38","in 10mM DMSO","AChR","Neuronal Signaling","Chelidonine (Stylophorin, Helidonine), a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.",353.37,"476-32-4",{"v":5,"d":"5.00"},14.15,"N/A","N/A","https://www.selleckchem.com/products/chelidonine.html","C20H19NO5","free base","Stylophorin, Helidonine","CN1CC2=C(C=CC3=C2OCO3)C4C(O)CC5=C(C=C6OCOC6=C5)C14",2.329,4,1,0]
["S9160","Ziyu-glycoside I","a11","L3000-38","in 10mM DMSO","Others","Others","Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.",766.95,"35286-58-9",{"v":100,"d":"100.00"},130.39,"N/A","N/A","https://www.selleckchem.com/products/ziyu-glycoside-i.html","C41H66O13","free base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1(C)O)C(=O)OC7OC(CO)C(O)C(O)C7O",2.178,5,7,6]
["S9162","Rubimaillin","b11","L3000-38","in 10mM DMSO","Acyltransferase","Metabolism","Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.",284.31,"55481-88-4",{"v":22,"d":"22.00"},77.38,"N/A","N/A","https://www.selleckchem.com/products/rubimaillin.html","C17H16O4","free base","Mollugin","COC(=O)C1=C(O)C2=C(C=CC=C2)C3=C1C=CC(C)(C)O3",3.139,3,1,2]
["S9163","Rhapontigenin","c11","L3000-38","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).",258.27,"500-65-2",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/rhapontigenin.html","C15H14O4","free base","Protigenin","COC1=CC=C(/C=C/C2=CC(=CC(=C2)O)O)C=C1O",3.073,1,3,3]
["S9164","Curdione","d11","L3000-38","in 10mM DMSO","Others","Others","Curdione, one of the major components of Curcuma zedoaria, shows an excellent antithrombotic activity in vivo.",236.35,"13657-68-6",{"v":47,"d":"47.00"},198.86,"N/A","N/A","https://www.selleckchem.com/products/curdione.html","C15H24O2","free base","N/A","CC(C)C1CC(=O)C(C)CC\\C=C(C)\\CC1=O",3.351,2,0,1]
["S9166","Griffonilide","e11","L3000-38","in 10mM DMSO","Others","Others","Griffonilide is a natural product that has been reported to induce bone remodeling activity resulting in structural changes.",168.15,"61371-55-9",{"v":34,"d":"34.00"},{"v":202.2,"d":"202.20"},"N/A","N/A","https://www.selleckchem.com/products/griffonilide.html","C8H8O4","free base","N/A","OC1C=CC2=CC(=O)OC2C1O",-0.423,2,2,0]
["S9167","Columbin","f11","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug.",358.39,"546-97-4",{"v":71,"d":"71.00"},198.11,"N/A","N/A","https://www.selleckchem.com/products/columbin.html","C20H22O6","free base","N/A","CC12CC(OC(=O)C1CCC3(C)C2C4OC(=O)C3(O)C=C4)C5=COC=C5",1.849,5,0,1]
["S9178","Sinapine thiocyanate","g11","L3000-38","in 10mM DMSO","Others","Immunology & Inflammation","Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.",368.45,"7431-77-8",{"v":73,"d":"73.00"},198.13,"N/A","N/A","https://www.selleckchem.com/products/sinapine-thiocyanate.html","C17H24N2O5S","free base","N/A","COC1=CC(=CC(=C1O)OC)/C=C/C(=O)OCC[N+](C)(C)C.[S-]C#N",1.287,4,1,8]
["S9180","Tussilagone","h11","L3000-38","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies.",390.51,"104012-37-5",{"v":78,"d":"78.00"},199.74,"N/A","N/A","https://www.selleckchem.com/products/tussilagone.html","C23H34O5","free base","N/A","CC/C(C)=C/C(=O)OC1CC(C(C)C)C2C(CC(=O)C2C(C)OC(C)=O)C1=C",4.326,5,0,8]
["S9181","Periplocin","a2","L3000-39","in 10mM DMSO","ATPase","Transmembrane Transporters","Periplocin (Periplocoside), extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.",696.82,"13137-64-9",{"v":100,"d":"100.00"},143.51,"N/A","N/A","https://www.selleckchem.com/products/periplocin.html","C36H56O13","free base","Periplocoside","COC1CC(OC(C)C1OC2OC(CO)C(O)C(O)C2O)OC3CCC4(C)C5CCC6(C)C(CCC6(O)C5CCC4(O)C3)C7=CC(=O)OC7",0.742,7,4,7]
["S9182","Crebanine","b2","L3000-39","in 10mM DMSO","Apoptosis related","Apoptosis","Crebanine, an aporphine alkaloid isolated from the crude hexane extract of the dried tuber of Stephania venosa, exhibits anti-cancer effects.",339.39,"25127-29-1",{"v":68,"d":"68.00"},200.36,"N/A","N/A","https://www.selleckchem.com/products/crebanine.html","C20H21NO4","free base","N/A","COC1=C(OC)C2=C(C=C1)C3=C4C(C2)N(C)CCC4=CC5=C3OCO5",3.335,4,0,2]
["S9184","Forsythoside B","c2","L3000-39","in 10mM DMSO","Immunology & Inflammation related,Interleukins,IκB/IKK,NF-κB,TNF-alpha","Immunology & Inflammation","Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.",{"v":756.7,"d":"756.70"},"81525-13-5",{"v":100,"d":"100.00"},132.15,"N/A","N/A","https://www.selleckchem.com/products/forsythoside-b.html","C34H44O19","free base","N/A","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(COC4OCC(O)(CO)C4O)C2OC(=O)/C=C/C5=CC(=C(O)C=C5)O)C(O)C(O)C1O",-0.925,8,10,14]
["S9185","Nitidine Chloride","d2","L3000-39","in 10mM DMSO","Anti-infection","Microbiology","Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.",383.82,"13063-04-2",{"v":11,"d":"11.00"},28.66,"N/A","N/A","https://www.selleckchem.com/products/nitidine-chloride.html","C21H18ClNO4","free base","N/A","[Cl-].COC1=CC2=C(C=C1OC)C3=C(C4=C(C=C3)C=C5OCOC5=C4)[N+](=C2)C",1.512,4,0,2]
["S9189","Oroxin A","e2","L3000-39","in 10mM DMSO","PPAR","Metabolism","Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.",432.38,"57396-78-8",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-a.html","C21H20O10","free base","Baicalein 7-O-glucoside","OCC1OC(OC2=CC3=C(C(=O)C=C(O3)C4=CC=CC=C4)C(=C2O)O)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9190","Oroxin B","f2","L3000-39","in 10mM DMSO","Akt,Apoptosis related,COX,PI3K,PTEN","Apoptosis","Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.",594.52,"114482-86-9",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-b.html","C27H30O15","free base","Hypocretin-2","OCC1OC(OCC2OC(OC3=C(O)C(=C4C(=O)C=C(OC4=C3)C5=CC=CC=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.267,6,9,7]
["S9193","Aristolochic acid A","g2","L3000-39","in 10mM DMSO","AP-1,NF-κB","NF-κB","Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae.Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities.",341.27,"313-67-7",{"v":6,"d":"6.00"},17.58,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/aristolochic-acid-a.html","C17H11NO7","Free Base","Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736","COC1=CC=CC2=C3C4=C(OCO4)C=C(C(O)=O)C3=C(C=C12)[N+]([O-])=O",2.922,4,0,3]
["S9201","Levistilide A","h2","L3000-39","in 10mM DMSO","P-gp","Neuronal Signaling","Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.",380.48,"88182-33-6",{"v":76,"d":"76.00"},199.75,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/levistilide-a.html","C24H28O4","Free Base","Diligustilide","CCC/C=C/1OC(=O)C2=C1CCC3C4CCC5(C23)\\C(OC(=O)C5=C4)=C\\CCC",{"v":4.97,"d":"4.970"},4,0,4]
["S9204","Oroxylin A","a3","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.",284.26,"480-11-5",{"v":56.9,"d":"56.90"},200.17,"N/A","N/A","https://www.selleckchem.com/products/oroxylin-a.html","C16H12O5","free base","6-Methoxybaicalein","COC1=C(O)C2=C(OC(=CC2=O)C3=CC=CC=C3)C=C1O",2.636,3,2,2]
["S9205","Hydroxygenkwanin","b3","L3000-39","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis., Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis.",300.26,"20243-59-8",{"v":60,"d":"60.00"},199.82,"N/A","N/A","https://www.selleckchem.com/products/hydroxygenkwanin.html","C16H12O6","free base","7-O-Methylluteolin","COC1=CC2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=C(O)C(=C3)O",2.394,3,3,2]
["S9211","Eriocitrin","c3","L3000-39","in 10mM DMSO","Others","Others","Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.",596.53,"13463-28-0",{"v":100,"d":"100.00"},167.64,"N/A","N/A","https://www.selleckchem.com/products/eriocitrin.html","C27H32O15","free base","eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside","CC1OC(OCC2OC(OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C(=C5)O)O)C(O)C(O)C2O)C(O)C(O)C1O",-0.657,6,9,6]
["S9217","Complanatuside","d3","L3000-39","in 10mM DMSO","Others","Others","Complanatuside, a flavonoid compound isolated from Astragalus complanatus and Lysimachia christinae, has anti-inflammation, lipid-lowering and hepatoprotective effects.",624.54,"116183-66-5",{"v":100,"d":"100.00"},160.12,"N/A","N/A","https://www.selleckchem.com/products/complanatuside.html","C28H32O16","free base","N/A","COC1=CC2=C(C(=C1)O)C(=O)C(=C(O2)C3=CC=C(OC4OC(CO)C(O)C(O)C4O)C=C3)OC5OC(CO)C(O)C(O)C5O",-1.762,7,9,8]
["S9221","Ferulaldehyde","e3","L3000-39","in 10mM DMSO","Heme Oxygenase","Immunology & Inflammation","Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.",178.18,"458-36-6",{"v":35,"d":"35.00"},196.43,"N/A","N/A","https://www.selleckchem.com/products/ferulaldehyde.html","C10H10O3","free base","Coniferaldehyde, Ferulyl aldehyde","COC1=CC(=CC=C1O)\\C=C\\C=O",1.691,2,1,3]
["S9225","Santalol","f3","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.",220.35,"11031-45-1","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/santalol.html","C15H24O","free base","N/A","CC(\\CO)=C/CCC1(C)C2CCC(C2)C1=C",3.662,0,1,4]
["S9226","Steviolbioside","g3","L3000-39","in 10mM DMSO","Bacterial","Microbiology","Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.",642.73,"41093-60-1",{"v":100,"d":"100.00"},155.59,"N/A","N/A","https://www.selleckchem.com/products/steviolbioside.html","C32H50O13","free base","CCRIS-6025","CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(O)=O",{"v":0.2,"d":"0.200"},5,7,7]
["S9228","Schisandrin C","h3","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.",384.42,"61301-33-5",{"v":76.9,"d":"76.90"},200.04,"N/A","N/A","https://www.selleckchem.com/products/schisandrin-c.html","C22H24O6","free base","N/A","COC1=C2OCOC2=CC3=C1C4=C(CC(C)C(C)C3)C=C5OCOC5=C4OC",4.868,6,0,2]
["S9230","Vaccarin","a4","L3000-39","in 10mM DMSO","Others","Others","Vaccarin, a major flavonoid glycoside found in Semen vaccariae, exhibits extensive biological activities including vascular endothelial cell protective effects.",726.63,"53452-16-7",{"v":100,"d":"100.00"},137.62,"N/A","N/A","https://www.selleckchem.com/products/vaccarin.html","C32H38O19","free base","N/A","OCC1OC(OC2=CC=C(C=C2)C3=CC(=O)C4=C(O)C(=C(O)C=C4O3)C5OC(CO)C(O)C(O)C5OC6OCC(O)C(O)C6O)C(O)C(O)C1O",-3.147,7,12,8]
["S9234","Schaftoside","b4","L3000-39","in 10mM DMSO","Lipase,MyD88,TLR","Metabolism","Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.",564.49,"51938-32-0",{"v":100,"d":"100.00"},177.15,"N/A","N/A","https://www.selleckchem.com/products/schaftoside.html","C26H28O14","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC=C(O)C=C4)C(=C2O)C5OCC(O)C(O)C5O",-1.862,4,10,4]
["S9240","Isofraxidin","c4","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.",222.19,"486-21-5",{"v":44,"d":"44.00"},198.03,"N/A","N/A","https://www.selleckchem.com/products/isofraxidin.html","C11H10O5","free base","6,8-Dimethoxyumbelliferone","COC1=CC2=C(OC(=O)C=C2)C(=C1O)OC",1.625,4,1,2]
["S9243","Protosappanin B","d4","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.",304.29,"102036-29-3",{"v":61,"d":"61.00"},200.46,"N/A","N/A","https://www.selleckchem.com/products/protosappanin-b.html","C16H16O6","free base","FT-0689654, Q-100961","OCC1(O)COC2=CC(=CC=C2C3=CC(=C(O)C=C3C1)O)O",1.486,1,4,1]
["S9249","Securinine","e4","L3000-39","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.",217.26,"5610-40-2",{"v":44,"d":"44.00"},202.52,"N/A","N/A","https://www.selleckchem.com/products/securinine.html","C13H15NO2","free base","N/A","O=C1OC23CC(C=CC2=C1)N4CCCCC34",1.449,2,0,0]
["S9250","Isosilybin","f4","L3000-39","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Isosilybin (Silymarin, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.",482.44,"72581-71-6",{"v":97,"d":"97.00"},201.06,"N/A","N/A","https://www.selleckchem.com/products/isosilybin.html","C25H22O10","free base","Silymarin, Isosilybinin, Q-100795","COC1=C(O)C=CC(=C1)C2OC3=C(OC2CO)C=C(C=C3)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S9251","Oxypeucedanin","g4","L3000-39","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.",286.28,"737-52-0",{"v":24,"d":"24.00"},83.83,"N/A","N/A","https://www.selleckchem.com/products/oxypeucedanin.html","C16H14O5","free base","N/A","CC1(C)OC1COC2=C3C=CC(=O)OC3=CC4=C2C=CO4",2.485,5,0,3]
["S9258","(+)-Isocorynoline","h4","L3000-39","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Isocorynoxeine, a major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM and shows various beneficial effects, including lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage.",{"v":341.4,"d":"341.40"},"475-67-2",{"v":32,"d":"32.00"},93.73,"N/A","N/A","https://www.selleckchem.com/products/isocorynoline.html","C20H23NO4","free base","N/A","COC1=C(O)C2=C(CC3N(C)CCC4=C3C2=C(OC)C(=C4)OC)C=C1",3.308,3,1,3]
["S9265","7-Epitaxol","a5","L3000-39","in 10mM DMSO","Others","Others","7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug.",853.91,"105454-04-4",{"v":100,"d":"100.00"},117.11,"N/A","N/A","https://www.selleckchem.com/products/7-epitaxol.html","C47H51NO14","free base/salt","7-Epipaclitaxel","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S9272","Koumine","b5","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.",{"v":306.4,"d":"306.40"},"1358-76-5",{"v":15,"d":"15.00"},48.96,"N/A","N/A","https://www.selleckchem.com/products/koumine.html","C20H22N2O","free base","N/A","CN1CC2(C=C)C3CC4OCC3C1CC25C4=NC6=CC=CC=C56",1.879,2,0,1]
["S9275","Isoguanosine","c5","L3000-39","in 10mM DMSO","FLT3,HDAC","Angiogenesis","Isoguanosine (Crotonoside) inhibits FLT3 and HDAC3/6 for the treatment of AML.Isoguanosine is a naturally occurring active isomer of guanosine that is found in the seeds of Croton tiglium.",283.24,"1818-71-9",{"v":57,"d":"57.00"},201.24,"N/A","N/A","https://www.selleckchem.com/products/isoguanosine.html","C10H13N5O5","free base","Crotonoside","NC1=NC(=O)NC2=C1N=C[N]2C3OC(CO)C(O)C3O",{"v":-2.38,"d":"-2.380"},4,5,2]
["S9276","Alisol B","d5","L3000-39","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.",{"v":472.7,"d":"472.70"},"18649-93-9",{"v":95,"d":"95.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/alisol-b.html","C30H48O4","free base","N/A","CC(CC(O)C1OC1(C)C)C2=C3CC(O)C4C5(C)CCC(=O)C(C)(C)C5CCC4(C)C3(C)CC2",4.782,2,2,4]
["S9277","Alisol A","e5","L3000-39","in 10mM DMSO","Others","Metabolism","Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes.",490.71,"19885-10-0",{"v":98,"d":"98.00"},199.71,"N/A","N/A","https://www.selleckchem.com/products/alisol-a.html","C30H50O5","free base","N/A","CC(CC(O)C(O)C(C)(C)O)C1=C2CC(O)C3C4(C)CCC(=O)C(C)(C)C4CCC3(C)C2(C)CC1",4.015,1,3,5]
["S9280","Demethoxycurcumin","f5","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.",338.35,"22608-11-3",{"v":68,"d":"68.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/demethoxycurcumin.html","C20H18O5","free base","N/A","COC1=CC(=CC=C1O)\\C=C\\C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",{"v":3.57,"d":"3.570"},3,2,7]
["S9284","Aloesin","g5","L3000-39","in 10mM DMSO","Tyrosinase","Proteases","Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.",394.37,"30861-27-9",{"v":78,"d":"78.00"},197.78,"N/A","N/A","https://www.selleckchem.com/products/aloesin.html","C19H22O9","free base","Aloe resin B","CC(=O)CC1=CC(=O)C2=C(C)C=C(O)C(=C2O1)C3OC(CO)C(O)C(O)C3O",-0.765,4,5,4]
["S9286","Neobavaisoflavone","h5","L3000-39","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.",322.35,"41060-15-5",{"v":64,"d":"64.00"},198.54,"N/A","N/A","https://www.selleckchem.com/products/neobavaisoflavone.html","C20H18O4","free base","N/A","CC(C)=CCC1=CC(=CC=C1O)C2=COC3=C(C=CC(=C3)O)C2=O",4.239,2,2,3]
["S9287","Genkwanin","a6","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities.",284.26,"437-64-9",{"v":57,"d":"57.00"},200.52,"N/A","N/A","https://www.selleckchem.com/products/genkwanin.html","C16H12O5","free base","Apigenin 7-methyl ether","COC1=CC2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=C(O)C=C3",2.636,3,2,2]
["S9289","Astragalin","b6","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.",448.38,"480-10-4",{"v":90,"d":"90.00"},200.72,"N/A","N/A","https://www.selleckchem.com/products/astragalin.html","C21H20O11","free base","kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside","OCC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC=C(O)C=C4)C(O)C(O)C1O",-0.058,4,7,4]
["S9291","Isopimpinellin","c6","L3000-39","in 10mM DMSO","Others","Metabolism","Isopimpinellin (5,8-Dimethoxypsoralen) is a natural product synthesized by numerous plant species. It may acts as an anticarcinogen.",246.22,"482-27-9",{"v":49,"d":"49.00"},199.01,"N/A","N/A","https://www.selleckchem.com/products/isopimpinellin.html","C13H10O5","free base","5,8-Dimethoxypsoralen","COC1=C2OC(=O)C=CC2=C(OC)C3=C1OC=C3",{"v":2.17,"d":"2.170"},5,0,2]
["S9293","Isoliquiritin","d6","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.",418.39,"5041-81-6",{"v":84,"d":"84.00"},200.77,"N/A","N/A","https://www.selleckchem.com/products/isoliquiritin.html","C21H22O9","free base","Neoisoliquritin","OCC1OC(OC2=CC=C(\\C=C\\C(=O)C3=C(O)C=C(O)C=C3)C=C2)C(O)C(O)C1O",1.046,3,6,6]
["S9295","Dauricine","e6","L3000-39","in 10mM DMSO","NF-κB","NF-κB","Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells.",624.77,"524-17-4",{"v":100,"d":"100.00"},160.06,"N/A","N/A","https://www.selleckchem.com/products/dauricine.html","C38H44N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(OC4=C(O)C=CC(=C4)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C=C3)N(C)CC2",7.245,5,1,10]
["S9297","Kirenol","f6","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.",338.48,"52659-56-0",{"v":68,"d":"68.00"},{"v":200.9,"d":"200.90"},"N/A","N/A","https://www.selleckchem.com/products/kirenol.html","C20H34O4","free base","N/A","CC1(CO)CC(O)CC2(C)C3CCC(C)(C=C3CCC12)C(O)CO",1.769,0,4,3]
["S9298","Corylin","g6","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.",320.34,"53947-92-5",{"v":64,"d":"64.00"},199.79,"N/A","N/A","https://www.selleckchem.com/products/corylin.html","C20H16O4","free base","N/A","CC1(C)OC2=CC=C(C=C2C=C1)C3=COC4=CC(=CC=C4C3=O)O",3.412,3,1,1]
["S9299","Ginsenoside F1","h6","L3000-39","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Ginsenoside F1, a pharmaceutical component of ginseng, is known to have antiaging, antioxidant, anticancer, and keratinocyte protective effects. Ginsenoside F1 exhibits competitive inhibition of the activity of CYP3A4 with Ki values of 67.8 ± 16.2 μM. Ginsenoside F1 also exhibited a weaker inhibition of the activity of CYP2D6.",638.87,"53963-43-2",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/ginsenoside-f1.html","C36H62O9","free base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(O)CC34C",2.873,2,7,7]
["S9302","Polyphyllin VI","a7","L3000-39","in 10mM DMSO","Pyroptosis","Apoptosis","Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.",{"v":738.9,"d":"738.90"},"55916-51-3",{"v":100,"d":"100.00"},135.34,"N/A","N/A","https://www.selleckchem.com/products/polyphyllin-vi.html","C39H62O13","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3(O)C2C)OC7OC(CO)C(O)C(O)C7OC8OC(C)C(O)C(O)C8O",1.381,6,6,5]
["S9307","Shanzhiside methyl ester","b7","L3000-39","in 10mM DMSO","Glucagon Receptor","GPCR & G Protein","Shanzhiside methylester is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist.",406.38,"64421-28-9",{"v":81,"d":"81.00"},199.32,"N/A","N/A","https://www.selleckchem.com/products/shanzhiside-methyl-ester.html","C17H26O11","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C1C(O)CC3(C)O",{"v":-3.07,"d":"-3.070"},5,5,5]
["S9312","Cyanidin-3-O-glucoside chloride","c7","L3000-39","in 10mM DMSO","Others","Others","Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects.",484.84,"7084-24-4",{"v":97,"d":"97.00"},200.07,"N/A","N/A","https://www.selleckchem.com/products/cyanidin-3-o-glucoside-chloride.html","C21H21ClO11","free base","Kuromanin chloride, Chrysontemin chloride, Glucocyanidin chloride","[Cl-].OCC1OC(OC2=C([O+]=C3C=C(O)C=C(O)C3=C2)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",-1.566,2,8,4]
["S9313","Atractylenolide III","d7","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities.",248.32,"73030-71-4",{"v":50,"d":"50.00"},201.36,"N/A","N/A","https://www.selleckchem.com/products/atractylenolide-iii.html","C15H20O3","free base","N/A","CC1=C2CC3C(=C)CCCC3(C)CC2(O)OC1=O",2.924,2,0,0]
["S9314","Atractylenolide II","e7","L3000-39","in 10mM DMSO","Others","Others","Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.",232.32,"73069-14-4",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"N/A","N/A","https://www.selleckchem.com/products/atractylenolide-ii.html","C15H20O2","free base","Asterolide, 2-Atractylenolide","CC1=C2CC3C(=C)CCCC3(C)CC2OC1=O",3.573,2,0,0]
["S9318","(20R)-Ginsenoside Rh1","f7","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","(20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.",638.87,"80952-71-2",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rh1.html","C36H62O9","free base","N/A","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(CC23C)OC5OC(CO)C(O)C(O)C5O",2.873,2,6,7]
["S9321","Topotecan","g7","L3000-39","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.",421.45,"123948-87-8",{"v":84,"d":"84.00"},199.31,"N/A","N/A","https://www.selleckchem.com/products/topotecan.html","C23H23N3O5","free base","NSC609699,Nogitecan,SKFS 104864A","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.577,4,1,3]
["S9328","5,6,7-Trimethoxyflavone","h7","L3000-39","in 10mM DMSO","Antiviral,Bacterial","Microbiology","5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.",312.32,"973-67-1",{"v":10,"d":"10.00"},32.02,"N/A","N/A","https://www.selleckchem.com/products/trimethoxyflavone.html","C18H16O5","free base","Baicalein Trimethyl Ether","COC1=CC2=C(C(=O)C=C(O2)C3=CC=CC=C3)C(=C1OC)OC",3.087,5,0,4]
["S9330","6-Hydroxy-4-methylcoumarin","a8","L3000-39","in 10mM DMSO","Others","Metabolism","6-Hydroxy-4-methylcoumarin is a chemical.",176.17,"2373-31-1",{"v":35,"d":"35.00"},198.67,"N/A","N/A","https://www.selleckchem.com/products/6-hydroxy-4-methylcoumarin.html","C10H8O3","free base","N/A","CC1=CC(=O)OC2=C1C=C(O)C=C2",2.104,2,1,0]
["S9336","Ethyl Coumarin-3-carboxylate","b8","L3000-39","in 10mM DMSO","Others","Others","Ethyl coumarin-3-carboxylate occupies an important position in the organic synthesis and is used in production of biologically active compounds.",218.21,"1846-76-0",{"v":43,"d":"43.00"},197.06,"N/A","N/A","https://www.selleckchem.com/products/ethyl-coumarin-3-carboxylate.html","C12H10O4","free base","N/A","CCOC(=O)C1=CC2=C(OC1=O)C=CC=C2",2.064,4,0,3]
["S9338","Octyl gallate","c8","L3000-39","in 10mM DMSO","Others","Microbiology","Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.",282.33,"1034-01-1",{"v":56,"d":"56.00"},198.35,"N/A","N/A","https://www.selleckchem.com/products/octyl-gallate.html","C15H22O5","free base","Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester","CCCCCCCCOC(=O)C1=CC(=C(O)C(=C1)O)O",4.112,2,3,9]
["S9339","S-(-)-Cotinine","d8","L3000-39","in 10mM DMSO","Others","Others","S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.,",176.22,"486-56-6","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/s-cotinine.html","C10H12N2O","free base","N/A","CN1C(CCC1=O)C2=CN=CC=C2",0.296,2,0,1]
["S9341","3,4-Dimethoxycinnamic acid","e8","L3000-39","in 10mM DMSO","Anti-infection","Microbiology","3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.",208.21,"2316-26-9",{"v":42,"d":"42.00"},201.72,"N/A","N/A","https://www.selleckchem.com/products/3-4-dimethoxycinnamic-acid.html","C11H12O4","free base","Caffeic acid dimethyl ether","COC1=CC=C(/C=C/C(O)=O)C=C1OC",1.894,3,0,4]
["S9347","Allitol","f8","L3000-39","in 10mM DMSO","Others","Others","Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds.",182.17,"488-44-8",{"v":36,"d":"36.00"},197.62,"N/A","N/A","https://www.selleckchem.com/products/allitol.html","C6H14O6","free base","Allodulcitol","OCC(O)C(O)C(O)C(O)CO",-2.941,0,6,5]
["S9354","Oxalic acid","g8","L3000-39","in 10mM DMSO","Others","Others","Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.",90.03,"144-62-7",{"v":18,"d":"18.00"},199.92,"N/A","N/A","https://www.selleckchem.com/products/oxalic-acid.html","C2H2O4","free base","Ethanedioic acid, Wood bleach","OC(=O)C(O)=O",-0.429,2,0,1]
["S9359","Anthraquinone-2-carboxylic Acid","h8","L3000-39","in 10mM DMSO","Others","Others","Anthraquinone-2-carboxylic Acid is a novel electron shuttling mediator, showing potent anti-inflammatory and antinociceptive activities in vivo.",252.22,"117-78-2",{"v":50,"d":"50.00"},198.24,"N/A","N/A","https://www.selleckchem.com/products/anthraquinone-2-carboxylic-acid.html","C15H8O4","free base","N/A","OC(=O)C1=CC=C2C(=O)C3=C(C=CC=C3)C(=O)C2=C1",2.438,3,0,1]
["S9360","4-Hydroxyquinazoline","a9","L3000-39","in 10mM DMSO","PARP","DNA Damage/DNA Repair","4-Hydroxyquinazoline (Quinazolin-4-ol, 4-Quinazolinol) is a PARP inhibitor with a high potency for PARP-1 with IC50 of 9.5 μM.",146.15,"491-36-1",{"v":29,"d":"29.00"},198.43,"N/A","N/A","https://www.selleckchem.com/products/4-hydroxyquinazoline-.html","C8H6N2O","free base","Quinazolin-4-ol, 4-Quinazolinol","O=C1NC=NC2=CC=CC=C12",{"v":0.75,"d":"0.750"},2,1,0]
["S9361","Coumarin-3-carboxylic acid","b9","L3000-39","in 10mM DMSO","Others","Others","Coumarin-3-carboxylic acid is used as a detector for hydroxyl radicals (.OH) in aqueous solution.",190.15,"531-81-7",{"v":38,"d":"38.00"},199.84,"N/A","N/A","https://www.selleckchem.com/products/coumarin-3-carboxylic-acid.html","C10H6O4","free base","N/A","OC(=O)C1=CC2=C(OC1=O)C=CC=C2",1.489,3,0,1]
["S9364","6-Hydroxycoumarin","c9","L3000-39","in 10mM DMSO","Others","Others","6-Hydroxycoumarin demonstrates cytotoxic effect against the cancer cell lines.",162.14,"6093-68-1",{"v":32,"d":"32.00"},197.36,"N/A","N/A","https://www.selleckchem.com/products/6-hydroxycoumarin.html","C9H6O3","free base","N/A","OC1=CC2=C(OC(=O)C=C2)C=C1",1.657,2,1,0]
["S9366","5'-Adenylic acid","d9","L3000-39","in 10mM DMSO","Others","Others","AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.",347.22,"61-19-8",{"v":34.9,"d":"34.90"},100.51,"N/A","N/A","https://www.selleckchem.com/products/5-adenylic-acid.html","C10H14N5O7P","free base","AMP, Adenosine monophosphate","NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O",-1.952,5,3,4]
["S9368","ADP","e9","L3000-39","in 10mM DMSO","Others","Others","ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.",{"v":427.2,"d":"427.20"},"58-64-0",{"v":6,"d":"6.00"},14.04,"N/A","N/A","https://www.selleckchem.com/products/adp.html","C10H15N5O10P2","free base","Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate","NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(=O)O[P](O)(O)=O)C(O)C3O",-2.239,6,3,6]
["S9372","Ethyl palmitate","f9","L3000-39","in 10mM DMSO","Others","Others","Ethyl palmitate (Ethyl hexadecanoate, Palmitic acid ethyl ester) is a long-chain fatty acid ethyl ester that is used as a hair- and skin-conditioning agent.",284.48,"628-97-7","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/ethyl-palmitate.html","C18H36O2","free base","Ethyl hexadecanoate, Palmitic acid ethyl ester","CCCCCCCCCCCCCCCC(=O)OCC",6.967,2,0,16]
["S9379","Dihydrocoumarin","g9","L3000-39","in 10mM DMSO","Others","Others","Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps.",148.16,"119-84-6","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/dihydrocoumarin.html","C9H8O2","free base","N/A","O=C1CCC2=C(O1)C=CC=C2",1.923,2,0,0]
["S9382","Thymine","h9","L3000-39","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.",126.11,"65-71-4",{"v":25,"d":"25.00"},198.23,"N/A","N/A","https://www.selleckchem.com/products/thymine.html","C5H6N2O2","free base","5-methyluracil","CC1=CNC(=O)NC1=O",-0.566,2,2,0]
["S9384","Sophocarpine Monohydrate","a10","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.",264.36,"145572-44-7",{"v":52,"d":"52.00"},{"v":196.7,"d":"196.70"},"N/A","N/A","https://www.selleckchem.com/products/sophocarpine-monohydrate.html","C15H24N2O2","free base","N/A","O.O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.187,1,0,0]
["S9387","Maackiain","b10","L3000-39","in 10mM DMSO","Anti-infection","Microbiology","Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.",284.26,"19908-48-6",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"N/A","N/A","https://www.selleckchem.com/products/maackiain.html","C16H12O5","free base","Demethylpterocarpin","OC1=CC2=C(C=C1)C3OC4=C(C=C5OCOC5=C4)C3CO2",2.467,4,1,0]
["S9392","Praeruptorin B","c10","L3000-39","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.",426.46,"73069-28-0",{"v":32,"d":"32.00"},75.04,"N/A","N/A","https://www.selleckchem.com/products/praeruptorin-b.html","C24H26O7","free base","N/A","C\\C=C(C)/C(=O)OC1C(OC(=O)\\C(C)=C/C)C(C)(C)OC2=C1C3=C(C=CC(=O)O3)C=C2",5.048,7,0,6]
["S9395","N-Benzoyl-(2R,3S)-3-phenylisoserine","d10","L3000-39","in 10mM DMSO","Others","Others","N-Benzoyl-(2R,3S)-3-phenylisoserine, also known as taxol side chain, is important for strong antitumor activity of taxol.",285.29,"132201-33-3",{"v":57,"d":"57.00"},199.79,"N/A","N/A","https://www.selleckchem.com/products/n-benzoyl-2r-3s-3-phenylisoserine.html","C16H15NO4","free base","taxol side chain","OC(C(NC(=O)C1=CC=CC=C1)C2=CC=CC=C2)C(O)=O",1.727,2,2,5]
["S9397","Alliin","e10","L3000-39","in 10mM DMSO","Others","Others","Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.",177.22,"556-27-4",{"v":3,"d":"3.00"},16.93,"N/A","N/A","https://www.selleckchem.com/products/alliin.html","C6H11NO3S","free base","S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine","NC(C[S](=O)CC=C)C(O)=O",-3.391,2,1,5]
["S9401","3,6'-Disinapoyl sucrose","f10","L3000-39","in 10mM DMSO","Others","Others","3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.",754.69,"139891-98-8",{"v":100,"d":"100.00"},132.51,"N/A","N/A","https://www.selleckchem.com/products/3-6-disinapoyl-sucrose.html","C34H42O19","free base","Disinapoyl sucrose","COC1=CC(=CC(=C1O)OC)\\C=C\\C(=O)OCC2OC(OC3(CO)OC(CO)C(O)C3OC(=O)/C=C/C4=CC(=C(O)C(=C4)OC)OC)C(O)C(O)C2O",0.162,11,8,17]
["S9402","(20R)-Protopanaxadiol","g10","L3000-39","in 10mM DMSO","VEGFR","Angiogenesis","(20R)-Protopanaxadiol, isolated from the roots of Panax ginseng, has protective effect on myocardial ischemia.",460.73,"7755-01-3",{"v":10,"d":"10.00"},{"v":21.7,"d":"21.70"},"N/A","N/A","https://www.selleckchem.com/products/20r-protopanaxadiol.html","C30H52O3","free base","N/A","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4CCC23C",5.789,0,2,4]
["S9404","Pristimerin","h10","L3000-39","in 10mM DMSO","Lipase","Metabolism","Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.",464.64,"1258-84-0",{"v":12,"d":"12.00"},25.83,"N/A","N/A","https://www.selleckchem.com/products/pristimerin.html","C30H40O4","free base","N/A","COC(=O)C1(C)CCC2(C)CCC3(C)C4=CC=C5C(=C(O)C(=O)C=C5C4(C)CCC3(C)C2C1)C",{"v":5.7,"d":"5.700"},3,1,2]
["S9406","Sauchinone","a11","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.",356.37,"177931-17-8",{"v":27,"d":"27.00"},75.76,"N/A","N/A","https://www.selleckchem.com/products/sauchinone.html","C20H20O6","free base","N/A","CC1CC2C3C(C1C)C4=C(OC35OCOC5=CC2=O)C=C6OCOC6=C4",2.787,6,0,0]
["S9407","Angoroside C","b11","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.",784.75,"115909-22-3",{"v":100,"d":"100.00"},127.43,"N/A","N/A","https://www.selleckchem.com/products/angoroside-c.html","C36H48O19","free base","N/A","COC1=CC=C(CCOC2OC(COC3OCC(O)C(O)C3O)C(OC(=O)/C=C/C4=CC=C(O)C(=C4)OC)C(OC5OC(C)C(O)C(O)C5O)C2O)C=C1O",-0.301,10,9,15]
["S9408","Beta-Elemonic acid","c11","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.",454.68,"28282-25-9",{"v":35,"d":"35.00"},76.98,"N/A","N/A","https://www.selleckchem.com/products/beta-elemonic.html","C30H46O3","free base","3-Oxotirucallenoic Acid","CC(C)=CCCC(C1CCC2(C)C3=C(CCC12C)C4(C)CCC(=O)C(C)(C)C4CC3)C(O)=O",7.153,2,0,5]
["S9411","Liensinine","d11","L3000-39","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"2586-96-1",{"v":100,"d":"100.00"},163.74,"N/A","N/A","https://www.selleckchem.com/products/liensinine.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9412","Flavokawain B","e11","L3000-39","in 10mM DMSO","Others","Others","Flavokawain B is a natural chalcone first isolated from extracts of kava roots that induces apoptosis in cancer cells.",284.31,"1775-97-9",{"v":42,"d":"42.00"},147.73,"N/A","N/A","https://www.selleckchem.com/products/flavokawain-b.html","C17H16O4","free base","N/A","COC1=CC(=C(C(=C1)O)C(=O)\\C=C\\C2=CC=CC=C2)OC",3.427,3,1,5]
["S9413","Yangonin","f11","L3000-39","in 10mM DMSO","Cannabinoid Receptor,Fungal","GPCR & G Protein","Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.",258.27,"500-62-9",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/yangonin.html","C15H14O4","free base","Y100550","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=O)O2)OC",2.211,4,0,4]
["S9414","Cyasterone","g11","L3000-39","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Cyasterone is the main phytoecdysteroid component found in Cyathula capitata. It is a natural EGFR inhibitor and maybe a promising anti-cancer agent.",520.65,"17086-76-9",{"v":100,"d":"100.00"},192.07,"N/A","N/A","https://www.selleckchem.com/products/cyasterone.html","C29H44O8","free base","N/A","CC1OC(=O)C(C)C1CC(O)C(C)(O)C2CCC3(O)C4=CC(=O)C5CC(O)C(O)CC5(C)C4CCC23C",1.476,3,3,4]
["S9421","Demethylnobiletin","h11","L3000-39","in 10mM DMSO","Leukotriene,Lipoxygenase","Metabolism","Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.",388.37,"2174-59-6",{"v":32,"d":"32.00"},{"v":82.4,"d":"82.40"},"N/A","N/A","https://www.selleckchem.com/products/demethylnobiletin.html","C20H20O8","free base","5-Demethylnobiletin","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C(=C(OC)C(=C3O)OC)OC",2.812,7,1,6]
["S9422","Diosbulbin B","a2","L3000-40","in 10mM DMSO","Others","Others","Diosbulbin B is the main hepatotoxic compound in Airpotato yam, which is traditionally used for treating thyroid disease and cancer.",344.36,"20086-06-0",{"v":27,"d":"27.00"},78.41,"N/A","N/A","https://www.selleckchem.com/products/diosbulbin-b.html","C19H20O6","free base","N/A","CC12CC(OC13CC(OC3=O)C4C5CC(CC24)OC5=O)C6=COC=C6",1.223,6,0,1]
["S9423","Narcissoside","b2","L3000-40","in 10mM DMSO","Others","Others","Narcissoside has antioxidant and antiproliferative activity in cancer.",624.54,"604-80-8",{"v":100,"d":"100.00"},160.12,"N/A","N/A","https://www.selleckchem.com/products/narcissoside.html","C28H32O16","free base","N/A","COC1=C(O)C=CC(=C1)C2=C(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)C(=O)C5=C(O)C=C(O)C=C5O2",-0.933,7,9,7]
["S9425","Trifolirhizin","c2","L3000-40","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening.",{"v":446.4,"d":"446.40"},"6807-83-6",{"v":89,"d":"89.00"},199.37,"N/A","N/A","https://www.selleckchem.com/products/trifolirhizin.html","C22H22O10","free base","N/A","OCC1OC(OC2=CC3=C(C=C2)C4OC5=C(C=C6OCOC6=C5)C4CO3)C(O)C(O)C1O",0.537,6,4,3]
["S9428","Brazilin","d2","L3000-40","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.",286.28,"474-07-7",{"v":57,"d":"57.00"},199.11,"N/A","N/A","https://www.selleckchem.com/products/brazilin.html","C16H14O5","free base","Natural Red 24","OC1=CC2=C(C=C1)C3C4=CC(=C(O)C=C4CC3(O)CO2)O",1.933,1,3,0]
["S9431","Dehydrocorydalin","e2","L3000-40","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.",366.43,"30045-16-0",{"v":73,"d":"73.00"},199.22,"N/A","N/A","https://www.selleckchem.com/products/dehydrocorydalin.html","C22H24NO4","free base","N/A","COC1=CC=C2C(=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC)C",4.648,4,0,4]
["S9432","Ginkgolic Acid","f2","L3000-40","in 10mM DMSO","Histone Acetyltransferase,SUMO","Ubiquitin","Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).",{"v":346.5,"d":"346.50"},"22910-60-7",{"v":69,"d":"69.00"},199.13,"N/A","N/A","https://www.selleckchem.com/products/ginkgolic-acid-s9432.html","C22H34O3","free base","N/A","CCCCCC\\C=C/CCCCCCCC1=CC=CC(=C1C(O)=O)O",7.646,1,1,14]
["S9434","8-Gingerol","g2","L3000-40","in 10mM DMSO","Others","Others","8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect.",322.44,"23513-08-8",{"v":64,"d":"64.00"},198.49,"N/A","N/A","https://www.selleckchem.com/products/8-gingerol.html","C19H30O4","free base","N/A","CCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",4.551,2,2,12]
["S9442","Bergaptol","h2","L3000-40","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol  is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.",202.16,"486-60-2",{"v":40,"d":"40.00"},197.86,"N/A","N/A","https://www.selleckchem.com/products/bergaptol.html","C11H6O4","free base","5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin","OC1=C2C=COC2=CC3=C1C=CC(=O)O3",1.961,3,1,0]
["S9449","Urocanic acid","a3","L3000-40","in 10mM DMSO","Others","Others","Urocanic acid is an intermediate in the catabolism of L-histidine.",138.12,"104-98-3",{"v":28,"d":"28.00"},202.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/urocanic-acid.html","C6H6N2O2","Free Base","N/A","OC(=O)/C=C/C1=C[NH]C=N1",0.243,2,1,2]
["S9455","Isorhamnetin 3-O-neohesperoside","b3","L3000-40","in 10mM DMSO","Others","Metabolism","Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has signiﬁcant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.",624.54,"55033-90-4",{"v":100,"d":"100.00"},160.12,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/isorhamnetin-3-o-neohesperoside.html","C28H32O16","Free Base","N/A","COC1=CC(=CC=C1O)C2=C(OC3OC(CO)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C(=O)C5=C(O2)C=C(O)C=C5O",-0.933,7,9,7]
["S9459","Mecamylamine Hydrochloride","c3","L3000-40","in 10mM DMSO","AChR","Neuronal Signaling","Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.",203.75,"826-39-1",{"v":41,"d":"41.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","N/A","C11H21N · HCl","Hydrochloride","N/A","Cl.CNC1(C)C2CCC(C2)C1(C)C",2.565,0,1,1]
["S9463","Demecarium Bromide","d3","L3000-40","in 10mM DMSO","AChR","Neuronal Signaling","Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent.",716.59,"56-94-0",{"v":100,"d":"100.00"},139.55,{"v":-1,"d":"-1.00"},"N/A","N/A","C32H52Br2N4O4","Bromide","N/A","[Br-].[Br-].CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C",-0.615,4,0,17]
["S9485","Waltonitone","e3","L3000-40","in 10mM DMSO","Others","Others","Waltonitone, an ursane-type pentacyclic triterpene extracted from Gentiana waltonii Burkill, exerts anti-tumor effect.",{"v":440.7,"d":"440.70"},"1252676-55-3",{"v":15,"d":"15.00"},34.04,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/waltonitone.html","C30H48O2","Free Base","N/A","CC1CCC2(CO)CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C2C1C",6.359,1,1,1]
["S9488","Lobetyolin","f3","L3000-40","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Praeruptorin D, a major pyranocoumarin isolated from Radix Peucedani, exhibits antitumor and anti-inflammatory activities.",396.43,"129277-38-9",{"v":20,"d":"20.00"},50.45,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/praeruptorin-d.html","C20H28O8","Free Base","N/A","C\\C=C\\C#CC#CC(O)C(OC1OC(CO)C(O)C(O)C1O)/C=C/CCCO",0.318,2,6,11]
["S9502","Madecassic acid","g3","L3000-40","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.",{"v":504.7,"d":"504.70"},"18449-41-7",{"v":100,"d":"100.00"},198.13,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/madecassic-acid.html","C30H48O6","Free Base","Brahmic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(O)=O",3.265,1,4,2]
["S9505","Oleanonic Acid","h3","L3000-40","in 10mM DMSO","Others","Cell Cycle","Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents.",454.68,"17990-42-0",{"v":91,"d":"91.00"},"200.14 <1","<1","N/A","http://www.selleckchem.com/products/oleanonic-acid.html","C30H46O3","Free Base","3-Ketooleanolic Acid, 3-Oxooleanolic acid","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C2C1)C(O)=O",6.547,2,0,1]
["S9507","(−)-Norepinephrine","a4","L3000-40","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.",169.18,"51-41-2",{"v":11,"d":"11.00"},65.02,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/norepinephrine.html","C8H11NO3","Free Base","Arterenol, Levarterenol, L-Noradrenaline","NCC(O)C1=CC(=C(O)C=C1)O",-0.059,0,4,2]
["S9510","Protriptyline hydrochloride","b4","L3000-40","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake.",299.84,"1225-55-4",{"v":60,"d":"60.00"},200.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/protriptyline-hydrochloride.html","C19H22ClN","hydrochloride","N/A","Cl.CNCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",4.423,0,1,4]
["S9511","Crocin I","c4","L3000-40","in 10mM DMSO","Others","Metabolism","Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice.",976.96,"94238-00-3",{"v":100,"d":"100.00"},102.36,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/crocin-i.html","C44H64O24","Free Base","N/A","CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)\\C=C\\C=C(C)\\C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O",-2.722,10,14,20]
["S9514","Rotundic acid","d4","L3000-40","in 10mM DMSO","Akt,mTOR,p38 MAPK","PI3K/Akt/mTOR","Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.",{"v":488.7,"d":"488.70"},"20137-37-5",{"v":98,"d":"98.00"},200.53,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/rotundic-acid.html","C30H48O5","Free Base","Rutundic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1(C)O)C(O)=O",4.253,1,2,2]
["S9515","Polyphyllin VII","e4","L3000-40","in 10mM DMSO","Others","Others","Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.",{"v":1049.2,"d":"1049.20"},"76296-75-8",{"v":100,"d":"100.00"},95.31,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/polyphyllin-vii.html","C51H84O22","Free Base","Y-0166","COC1(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C1C)OC7OC(CO)C(OC8OC(CO)C(O)C8O)C(OC9OC(C)C(O)C(O)C9O)C7O",-1.313,10,12,16]
["S9554","Bakkenolide A","f4","L3000-40","in 10mM DMSO","Others","Others","Bakkenolide A (Fukinanolid), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation.",234.33,"19906-72-0",{"v":47,"d":"47.00"},200.57,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bakkenolide-a.html","C15H22O2","Free Base","Fukinanolid","CC1CCCC2CC3(CC12C)C(=C)COC3=O",3.389,2,0,0]
["S2933","AM580","g4","L3000-40","in 10mM DMSO","Retinoid Receptor","Metabolism","AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.",351.44,"102121-60-8",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://www.selleck.cn/products/am580.html","C22H25NO3","Free Base","N/A","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S2934","Ensartinib (X-396) dihydrochloride","h4","L3000-40","in 10mM DMSO","ALK","Angiogenesis","Ensartinib (X-396) is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.",634.36,"2137030-98-7",{"v":100,"d":"100.00"},157.64,{"v":27,"d":"27.00"},42.56,"http://www.selleck.cn/products/ensartinib-dihydrochloride.html","C26H29Cl4FN6O3","Dihydrochloride","N/A","Cl.Cl.CC1CN(CC(C)N1)C(=O)C2=CC=C(NC(=O)C3=NN=C(N)C(=C3)OC(C)C4=C(Cl)C(=CC=C4Cl)F)C=C2",5.051,5,3,6]
["S4421","Josamycin","a5","L3000-40","in 10mM DMSO","Antibiotics","Microbiology","Josamycin (EN-141, Kitasamycin A3, Leucomycin A3, Turimycin A5) is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.",827.99,"16846-24-5",{"v":100,"d":"100.00"},120.77,"<1","N/A","http://www.selleck.cn/products/josamycin.html","C42H69NO15","Free Base","EN-141, Kitasamycin A3, Leucomycin A3, Turimycin A5","COC1C(CC(=O)OC(C)C/C=C/C=C/C(O)C(C)CC(CC=O)C1OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(C2O)N(C)C)OC(C)=O",2.957,12,2,14]
["S6526","SKLB 610","b5","L3000-40","in 10mM DMSO","FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR.",415.37,"1125780-41-7",{"v":83,"d":"83.00"},199.82,"<1","N/A","http://www.selleck.cn/products/sklb610.html","C21H16F3N3O3","Free Base","N/A","CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)C3=CC=CC(=C3)C(F)(F)F)C=C2",3.603,4,2,6]
["S6530","EBE-A22","c5","L3000-40","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.",374.23,"229476-53-3",{"v":9,"d":"9.00"},24.05,"<1","N/A","http://www.selleck.cn/products/ebe-a22.html","C17H16BrN3O2","Free Base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)N(C)C3=CC=CC(=C3)Br",4.398,4,0,4]
["S6531","Bohemine","d5","L3000-40","in 10mM DMSO","CDK","Cell Cycle","Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.",340.42,"189232-42-6",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://www.selleck.cn/products/bohemine.html","C18H24N6O","Free Base","N/A","CC(C)[N]1C=NC2=C1N=C(NCCCO)N=C2NCC3=CC=CC=C3",2.482,3,3,8]
["S6534","CZC-54252","e5","L3000-40","in 10mM DMSO","LRRK2","Autophagy","CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively.",504.99,"1191911-27-9",{"v":100,"d":"100.00"},198.02,"<1","N/A","http://www.selleck.cn/products/czc-54252.html","C22H25ClN6O4S","Free Base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3N[S](C)(=O)=O)C=CC(=C1)N4CCOCC4",{"v":3.62,"d":"3.620"},6,3,8]
["S6539","ASP5878","f5","L3000-40","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.",407.37,"1453208-66-6",{"v":81,"d":"81.00"},198.84,"<1","N/A","http://www.selleck.cn/products/asp5878.html","C18H19F2N5O4","Free Base","N/A","COC1=C(F)C(=C(F)C(=C1)OC)COC2=CN=C(NC3=C[N](CCO)N=C3)N=C2",2.178,6,2,9]
["S6540","NG 52","g5","L3000-40","in 10mM DMSO","CDK","Cell Cycle","NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively.",346.81,"212779-48-1",{"v":69,"d":"69.00"},198.96,"<1","N/A","http://www.selleck.cn/products/ng-52.html","C16H19ClN6O","Free Base","N/A","CC(C)[N]1C=NC2=C1N=C(NCCO)N=C2NC3=CC(=CC=C3)Cl",3.242,3,3,6]
["S6546","PD153035","h5","L3000-40","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM).",360.21,"153436-54-5",{"v":6,"d":"6.00"},16.66,"<1","N/A","http://www.selleck.cn/products/pd153035.html","C16H14BrN3O2","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=NC=N2)NC3=CC(=CC=C3)Br",4.193,4,1,4]
["S6552","CYM5541","a6","L3000-40","in 10mM DMSO","S1P Receptor","GPCR & G Protein","CYM5541 (ML249) is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM.",316.44,"945128-26-7",{"v":32,"d":"32.00"},101.13,"<1","N/A","http://www.selleck.cn/products/cym5541.html","C19H28N2O2","Free Base","ML249","O=C(N(C1CCCCC1)C2CCCCC2)C3=NOC(=C3)C4CC4",4.746,3,0,4]
["S6558","Irosustat (BN83495)","b6","L3000-40","in 10mM DMSO","Others","Metabolism","Irosustat (STX64, BN83495), a tricyclic coumarin sulfamate, is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor with an IC50 of 8 nM.",309.34,"288628-05-7",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://www.selleck.cn/products/irosustat.html","C14H15NO5S","Free Base","STX64","N[S](=O)(=O)OC1=CC=C2C3=C(CCCCC3)C(=O)OC2=C1",2.527,3,1,2]
["S6564","ML348","c6","L3000-40","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.",415.79,"899713-86-1",{"v":83,"d":"83.00"},199.62,"<1","N/A","http://www.selleck.cn/products/ml348.html","C18H17ClF3N3O3","Free Base","GNF-Pf-1127","FC(F)(F)C1=CC(=C(Cl)C=C1)NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3",2.839,3,1,5]
["S6568","ML346","d6","L3000-40","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.",272.26,"100872-83-1",{"v":27,"d":"27.00"},99.17,"<1","N/A","http://www.selleck.cn/products/ml346.html","C14H12N2O4","Free Base","N/A","COC1=CC=C(\\C=C\\C=C2C(=O)NC(=O)NC2=O)C=C1",1.315,4,2,3]
["S6572","ML335","e6","L3000-40","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.",373.25,"825658-06-8",{"v":75,"d":"75.00"},200.94,"<1","N/A","http://www.selleck.cn/products/ml335.html","C15H14Cl2N2O3S","Free Base","N/A","C[S](=O)(=O)NC1=CC=C(C=C1)C(=O)NCC2=C(Cl)C=C(Cl)C=C2",2.861,3,2,5]
["S6589","Norethisterone Enanthate","f6","L3000-40","in 10mM DMSO","Others","Others","Norethisterone Enanthate (Norethindrone Enanthate) is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women.",410.59,"3836-23-5",{"v":82,"d":"82.00"},199.71,"<1","N/A","http://www.selleck.cn/products/norethisterone-enanthate.html","C27H38O3","Free Base","Norethindrone Enanthate","CCCCCCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4C3CCC12C)C#C",7.186,3,0,7]
["S6593","Methylprednisolone sodium succinate","g6","L3000-40","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methylprednisolone sodium succinate (U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium) is a corticosteroid medication that reduces inflammation.",496.53,"2375-03-3",{"v":99,"d":"99.00"},199.38,{"v":99,"d":"99.00"},199.38,"http://www.selleck.cn/products/methylprednisolone-sodium-succinate.html","C26H33NaO8","Sodium succinate","U-9088, 6α-Methylprednisolone 21-hemisuccinate Sodium","[Na+].CC1CC2C3CCC(O)(C(=O)COC(=O)CCC([O-])=O)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",0.262,4,1,7]
["S6595","THZ531","h6","L3000-40","in 10mM DMSO","CDK","Cell Cycle","THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively.",558.07,"1702809-17-3",{"v":100,"d":"100.00"},179.19,"<1","N/A","http://www.selleck.cn/products/thz531.html","C30H32ClN7O2","Free Base","N/A","CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)N2CCCC(C2)NC3=NC(=C(Cl)C=N3)C4=C[NH]C5=C4C=CC=C5",4.645,4,3,8]
["S6596","AG-126","a7","L3000-40","in 10mM DMSO","ERK","MAPK","AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.",215.16,"118409-62-4",{"v":43,"d":"43.00"},199.85,"<1","N/A","http://www.selleck.cn/products/ag-126.html","C10H5N3O3","Free Base","N/A","OC1=CC(=CC=C1[N+]([O-])=O)C=C(C#N)C#N",1.668,0,1,2]
["S6598","IRAK-1-4 Inhibitor I","b7","L3000-40","in 10mM DMSO","IRAK","Immunology & Inflammation","IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested.",395.41,"509093-47-4",{"v":11,"d":"11.00"},27.82,"<1","N/A","http://www.selleck.cn/products/irak-1-4-inhibitor-i.html","C20H21N5O4","Free Base","N/A","[O-][N+](=O)C1=CC=CC(=C1)C(=O)NC2=NC3=C(C=CC=C3)[N]2CCN4CCOCC4",2.598,3,1,6]
["S6599","KM11060","c7","L3000-40","in 10mM DMSO","CFTR","Transmembrane Transporters","KM11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation.",422.33,"774549-97-2",{"v":84,"d":"84.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://www.selleck.cn/products/km11060.html","C19H17Cl2N3O2S","Free Base","N/A","ClC1=CC=C(C=C1)[S](=O)(=O)N2CCN(CC2)C3=CC=NC4=C3C=CC(=C4)Cl",4.091,3,0,3]
["S6602","TB5","d7","L3000-40","in 10mM DMSO","MAO","Metabolism","TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.",336.25,"948841-07-4",{"v":67,"d":"67.00"},199.26,"<1","N/A","http://www.selleck.cn/products/tb5.html","C15H14BrNOS","Free Base","N/A","CN(C)C1=CC=C(\\C=C\\C(=O)C2=CC=C(Br)S2)C=C1",4.385,1,0,4]
["S6607","YL-109","e7","L3000-40","in 10mM DMSO","Others","Metabolism","YL-109 is a novel antitumor agent that has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.",257.31,"36341-25-0",{"v":51,"d":"51.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://www.selleck.cn/products/yl-109.html","C14H11NO2S","Free Base","N/A","COC1=CC(=CC=C1O)C2=NC3=CC=CC=C3S2",{"v":3.58,"d":"3.580"},2,1,2]
["S6616","ETC-159","f7","L3000-40","in 10mM DMSO","PORCN","Stem Cells & Wnt","ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.",391.38,"1638250-96-0",{"v":78,"d":"78.00"},199.29,"<1","N/A","http://www.selleck.cn/products/etc-159.html","C19H17N7O3","Free Base","ETC-1922159","CN1C(=O)N(C)C2=C([N](CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4)C=N2)C1=O",1.404,6,1,4]
["S6617","MSX-122","g7","L3000-40","in 10mM DMSO","CXCR","Immunology & Inflammation","MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).",292.34,"897657-95-3",{"v":3,"d":"3.00"},10.26,"<1","N/A","http://www.selleck.cn/products/msx-122.html","C16H16N6","Free Base","Q-122","C(NC1=NC=CC=N1)C2=CC=C(CNC3=NC=CC=N3)C=C2",2.099,4,2,6]
["S6619","ABT 702 dihydrochloride","h7","L3000-40","in 10mM DMSO","Adenosine Kinase","Neuronal Signaling","ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation.",536.25,"1188890-28-9",{"v":100,"d":"100.00"},186.48,"<1","N/A","http://www.selleck.cn/products/abt-702-dihydrochloride.html","C22H21BrCl2N6O","Dihydrochloride","N/A","Cl.Cl.NC1=C2C(=NC=N1)N=C(C=C2C3=CC(=CC=C3)Br)C4=CN=C(C=C4)N5CCOCC5",4.441,5,1,3]
["S6620","Danirixin (GSK1325756)","a8","L3000-40","in 10mM DMSO","CXCR,Interleukins","Immunology & Inflammation","Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 (IL-8) binding = 12.5 nM), selective, and reversible CXCR2 antagonist.",{"v":441.9,"d":"441.90"},"954126-98-8",{"v":88,"d":"88.00"},199.14,"<1","N/A","http://www.selleck.cn/products/danirixin.html","C19H21ClFN3O4S","Free Base","N/A","CC1=C(NC(=O)NC2=C(O)C(=C(Cl)C=C2)[S](=O)(=O)C3CCCNC3)C=CC=C1F",3.255,3,4,4]
["S6623","APY29","b8","L3000-40","in 10mM DMSO","IRE1","ER stress & UPR","APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM).",332.36,"1216665-49-4",{"v":32,"d":"32.00"},96.28,"<1","N/A","http://www.selleck.cn/products/apy29.html","C17H16N8","Free Base","N/A","C1CC1C2=CC(=N[NH]2)NC3=NC(=NC=C3)NC4=CC=C5N=C[NH]C5=C4",3.613,4,4,5]
["S6625","Temsavir (BMS-626529)","c8","L3000-40","in 10mM DMSO","HIV Protease","Microbiology","Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.",473.48,"701213-36-7",{"v":95,"d":"95.00"},200.64,"<1","N/A","http://www.selleck.cn/products/temsavir-bms-626529.html","C24H23N7O4","Free Base","N/A","COC1=CN=C([N]2C=NC(=N2)C)C3=C1C(=C[NH]3)C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5",1.174,7,1,5]
["S6626","Brequinar (DUP785)","d8","L3000-40","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.",375.37,"96187-53-0",{"v":37,"d":"37.00"},98.57,"<1","N/A","http://www.selleck.cn/products/brequinar.html","C23H15F2NO2","Free Base","NSC 368390","CC1=C(N=C2C=CC(=CC2=C1C(O)=O)F)C3=CC=C(C=C3)C4=C(F)C=CC=C4",6.008,2,0,3]
["S6628","E7820","e8","L3000-40","in 10mM DMSO","Others","Angiogenesis","E7820 is a unique angiogenesis inhibitor with antitumor activities.",336.37,"289483-69-8",{"v":67,"d":"67.00"},199.19,"<1","N/A","http://www.selleck.cn/products/e7820.html","C17H12N4O2S","Free Base","N/A","CC1=C2C(=C(N[S](=O)(=O)C3=CC(=CC=C3)C#N)C=C1)[NH]C=C2C#N",2.855,2,2,3]
["S6629","GNE-617","f8","L3000-40","in 10mM DMSO","NAMPT","Metabolism","GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.",427.42,"1362154-70-8",{"v":42,"d":"42.00"},98.26,"<1","N/A","http://www.selleck.cn/products/gne-617.html","C21H15F2N3O3S","Free Base","N/A","FC1=CC(=CC(=C1)[S](=O)(=O)C2=CC=C(CNC(=O)C3=C[N]4C=CN=C4C=C3)C=C2)F",2.875,4,1,5]
["S6631","Belotecan (CKD-602) hydrochloride","g8","L3000-40","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.",469.96,"213819-48-8",{"v":47,"d":"47.00"},100.01,{"v":4,"d":"4.00"},8.51,"http://www.selleck.cn/products/belotecan-ckd-602-hydrochloride.html","C25H28ClN3O4","Hydrochloride","N/A","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=CC5=C4CCNC(C)C)C2=O",2.713,4,1,5]
["S6633","AM 095","h8","L3000-40","in 10mM DMSO","LPA Receptor","GPCR & G Protein","AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.",456.49,"1228690-36-5",{"v":91,"d":"91.00"},199.35,"<1","N/A","http://www.selleck.cn/products/am-095.html","C27H24N2O5","Free Base","N/A","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(C=C2)C3=CC=C(CC(O)=O)C=C3)C4=CC=CC=C4",5.284,5,1,8]
["S6637","HC-067047","a9","L3000-40","in 10mM DMSO","TRP Channel","Transmembrane Transporters","HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively.",471.51,"883031-03-6",{"v":94,"d":"94.00"},199.36,"<1","N/A","http://www.selleck.cn/products/hc-067047.html","C26H28F3N3O2","Free Base","N/A","CC1=C(C=C([N]1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F",{"v":4.7,"d":"4.700"},2,1,8]
["S6643","R-7050","b9","L3000-40","in 10mM DMSO","TNF-alpha","Apoptosis","R-7050 is a cell permeable TNF-α receptor antagonist and is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.",380.77,"303997-35-5",{"v":18,"d":"18.00"},47.27,"<1","N/A","http://www.selleck.cn/products/r-7050.html","C16H8ClF3N4S","Free Base","N/A","FC(F)(F)C1=NN=C2[N]1C3=C(C=CC(=C3)Cl)N=C2SC4=CC=CC=C4",5.606,3,0,3]
["S6645","AZD5069","c9","L3000-40","in 10mM DMSO","CXCR","Immunology & Inflammation","AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.",476.52,"878385-84-3",{"v":95,"d":"95.00"},199.36,"<1","N/A","http://www.selleck.cn/products/azd-5069.html","C18H22F2N4O5S2","Free Base","N/A","CC(OC1=NC(=NC(=C1)N[S](=O)(=O)N2CCC2)SCC3=C(F)C(=CC=C3)F)C(O)CO",{"v":1.88,"d":"1.880"},5,3,10]
["S6646","Ciforadenant (CPI-444)","d9","L3000-40","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.",407.43,"1202402-40-1",{"v":81,"d":"81.00"},198.81,"<1","N/A","http://www.selleck.cn/products/cpi-444.html","C20H21N7O3","Free Base","V81444","CC1=CC=C(O1)C2=C3N=N[N](CC4=NC(=CC=C4)COC5CCOC5)C3=NC(=N2)N",1.769,8,1,6]
["S6655","WM-8014","e9","L3000-40","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.",384.42,"2055397-18-5",{"v":77,"d":"77.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://www.selleck.cn/products/wm-8014.html","C20H17FN2O3S","Free Base","N/A","CC1=CC(=CC(=C1F)C(=O)NN[S](=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3",3.784,3,2,5]
["S6710","SGC-GAK-1","f9","L3000-40","in 10mM DMSO","Serine/threonin kinase","Metabolism","SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase.",389.24,"2226517-76-4",{"v":78,"d":"78.00"},200.39,"<1","N/A","http://www.selleck.cn/products/sgc-gak-1.html","C18H17BrN2O3","Free Base","N/A","COC1=CC(=CC(=C1OC)OC)NC2=C3C=C(Br)C=CC3=NC=C2",4.265,4,1,5]
["S6711","IQ-1S","g9","L3000-40","in 10mM DMSO","JNK","MAPK","IQ-1S is a JNK3 inhibitor with Kd values of 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively.",247.25,"23146-22-7",{"v":49,"d":"49.00"},198.18,"<1","N/A","http://www.selleck.cn/products/iq-1s.html","C15H9N3O","Free Base","N/A","O\\N=C\\1C2=CC=CC=C2C3=NC4=CC=CC=C4N=C13",3.311,3,0,0]
["S6713","ITD-1","h9","L3000-40","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I (TGFBR1) or type II (TGFBR2) TGFβ receptors but potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A.",415.52,"1099644-42-4",{"v":83,"d":"83.00"},199.75,"<1","N/A","http://www.selleck.cn/products/itd-1.html","C27H29NO3","Free Base","N/A","CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C)(C)C2",4.434,3,1,5]
["S6714","INH14","a10","L3000-40","in 10mM DMSO","IκB/IKK,NF-κB","NF-κB","INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.",{"v":240.3,"d":"240.30"},"200134-22-1",{"v":48,"d":"48.00"},199.75,"<1","N/A","http://www.selleck.cn/products/inh14.html","C15H16N2O","Free Base","N/A","CCC1=CC=C(NC(=O)NC2=CC=CC=C2)C=C1",3.465,1,2,3]
["S6715","YHO-13177","b10","L3000-40","in 10mM DMSO","BCRP","Transmembrane Transporters","YHO-13177, a novel acrylonitrile derivative, is a potent BCRP/ABCG2 inhibitor.",370.47,"912287-56-0",{"v":74,"d":"74.00"},199.75,"<1","N/A","http://www.selleck.cn/products/yho-13177.html","C20H22N2O3S","Free Base","N/A","COC1=C(OC)C=C(C=C1)/C(=C/C2=CC=C(S2)N3CCC(O)CC3)C#N",3.295,2,1,5]
["S6716","NSC 185058","c10","L3000-40","in 10mM DMSO","Autophagy","Autophagy","NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways.",215.27,"39122-38-8",{"v":43,"d":"43.00"},199.75,"<1","N/A","http://www.selleck.cn/products/nsc-185058.html","C11H9N3S","Free Base","N/A","S=C(NC1=NC=CC=C1)C2=NC=CC=C2",2.652,2,1,3]
["S6717","TCS-OX2-29","d10","L3000-40","in 10mM DMSO","OX Receptor","GPCR & G Protein","TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively).",397.51,"372523-75-6",{"v":87,"d":"87.00"},218.86,"<1","N/A","http://www.selleck.cn/products/tcs-ox2-29.html","C23H31N3O3","Free Base","N/A","COC1=CC2=C(CN(CC2)C(=O)C(NCC3=CC=NC=C3)C(C)(C)C)C=C1OC",2.709,4,1,7]
["S6718","MKT-077","e10","L3000-40","in 10mM DMSO","Dyes","Others","MKT-077 (FJ-776) is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems.",{"v":432,"d":"432.00"},"147366-41-4",{"v":13,"d":"13.00"},30.09,{"v":86,"d":"86.00"},199.07,"http://www.selleck.cn/products/mkt-077.html","C21H22ClN3OS2","Free Base","FJ-776","[Cl-].CCN\\1C(=O)\\C(SC1=C\\C2=CC=CC=[N+]2CC)=C3/SC4=CC=CC=C4N3C",2.489,1,0,3]
["S6723","Darovasertib (LXS-196)","f10","L3000-40","in 10mM DMSO","PKC","Cytoskeletal Signaling","Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC).",472.47,"1874276-76-2",{"v":22,"d":"22.00"},46.56,"<1","N/A","http://www.selleck.cn/products/lxs-196.html","C22H23F3N8O","Free Base","IDE-196","CC1(N)CCN(CC1)C2=CC=CN=C2NC(=O)C3=NC(=CN=C3N)C4=NC=CC=C4C(F)(F)F",{"v":1.6,"d":"1.600"},5,3,5]
["S6724","SR1001","g10","L3000-40","in 10mM DMSO","ROR","Transmembrane Transporters","SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for  RORα and RORγ respectively.",{"v":477.4,"d":"477.40"},"1335106-03-0",{"v":95,"d":"95.00"},198.99,"<1","N/A","http://www.selleck.cn/products/sr1001.html","C15H13F6N3O4S2","Free Base","N/A","CC(=O)NC1=NC(=C(S1)[S](=O)(=O)NC2=CC=C(C=C2)C(O)(C(F)(F)F)C(F)(F)F)C",2.137,4,2,7]
["S6726","MK1064","h10","L3000-40","in 10mM DMSO","OX Receptor","GPCR & G Protein","MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.",{"v":461.9,"d":"461.90"},"1207253-08-4",{"v":92,"d":"92.00"},199.18,"<1","N/A","http://www.selleck.cn/products/mk1064.html","C24H20ClN5O3","Free Base","N/A","COC1=C(OC)N=C(CNC(=O)C2=CC(=CN=C2C3=NC=CC=C3)C4=CC(=CN=C4)Cl)C=C1",3.298,7,1,7]
["S6727","AX-024 HCl","a11","L3000-40","in 10mM DMSO","CD markers,IFN,Interleukins,TNF-alpha","Transmembrane Transporters","AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.",375.86,"1704801-24-0",{"v":75,"d":"75.00"},199.54,{"v":4,"d":"4.00"},10.64,"http://www.selleck.cn/products/ax-024-hcl.html","C21H23ClFNO2","Hydrochloride","N/A","Cl.COC1=CC2=C(OCC(=C2C3=CC=C(F)C=C3)CN4CCCC4)C=C1",4.579,2,0,4]
["S6728","IDO-IN-1","b11","L3000-40","in 10mM DMSO","IDO/TDO","Metabolism","IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.",316.09,"914638-30-5",{"v":63,"d":"63.00"},199.31,"<1","N/A","http://www.selleck.cn/products/ido-in-1.html","C9H7BrFN5O2","Free Base","N/A","NC1=NON=C1C(NO)=NC2=CC=C(F)C(=C2)Br",1.661,4,2,3]
["S6730","CC-401 Hydrochloride","c11","L3000-40","in 10mM DMSO","JNK","MAPK","CC-401 is a potent inhibitor of JNK with at least 40-fold selectivity against other related kinases.",424.93,"1438391-30-0",{"v":85,"d":"85.00"},200.03,{"v":85,"d":"85.00"},200.03,"http://www.selleck.cn/products/cc-401-hydrochloride.html","C22H25ClN6O","Hydrochloride","N/A","Cl.C1CCN(CC1)CCOC2=CC(=CC=C2)C3=N[NH]C4=CC=C(C=C34)C5=NC=N[NH]5",4.527,4,2,6]
["S6732","7ACC2","d11","L3000-40","in 10mM DMSO","MCT","Transmembrane Transporters","7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.",309.32,"1472624-85-3",{"v":62,"d":"62.00"},200.44,"<1","N/A","http://www.selleck.cn/products/7acc2.html","C18H15NO4","Free Base","N/A","CN(CC1=CC=CC=C1)C2=CC3=C(C=C2)C=C(C(O)=O)C(=O)O3",3.235,3,0,4]
["S6734","PF-670462","e11","L3000-40","in 10mM DMSO","Casein Kinase","Metabolism","PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively.",410.32,"950912-80-8",{"v":82,"d":"82.00"},199.84,{"v":82,"d":"82.00"},199.84,"http://www.selleck.cn/products/pf-670462.html","C19H22Cl2FN5","Free Base","N/A","Cl.Cl.NC1=NC=CC(=N1)C2=C(N=C[N]2C3CCCCC3)C4=CC=C(F)C=C4",4.931,3,1,3]
["S6735","JD-5037","f11","L3000-40","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","JD-5037 is a peripherally restricted (PR) cannabinoid-1 receptor blocker with an IC50 value of 2 nM for CB1 receptor and > 1000 nM for CB2 receptor.",572.51,"1392116-14-1",{"v":100,"d":"100.00"},174.67,"<1","N/A","http://www.selleck.cn/products/id-5037.html","C27H27Cl2N5O3S","Free Base","N/A","CC(C)C(N=C(N[S](=O)(=O)C1=CC=C(Cl)C=C1)N2CC(C3=CC=CC=C3)C(=N2)C4=CC=C(Cl)C=C4)C(N)=O",5.552,5,2,9]
["S6737","C7280948","g11","L3000-40","in 10mM DMSO","PRMT","Methylation","C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro.",276.35,"587850-67-7",{"v":55,"d":"55.00"},199.02,"<1","N/A","http://www.selleck.cn/products/c7280948.html","C14H16N2O2S","Free Base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NCCC2=CC=CC=C2",1.899,2,2,5]
["S6739","MN 64","h11","L3000-40","in 10mM DMSO","PARP","DNA Damage/DNA Repair","MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.",264.32,"92831-11-3",{"v":53,"d":"53.00"},200.51,"<1","N/A","http://www.selleck.cn/products/mn-64.html","C18H16O2","Free Base","N/A","CC(C)C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC=C3",{"v":4.33,"d":"4.330"},2,0,2]
["S6740","DB07268","a2","L3000-41","in 10mM DMSO","Chk,JNK","MAPK","DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM and exhibits at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK.",321.33,"929007-72-7",{"v":64,"d":"64.00"},199.17,"<1","N/A","http://www.selleck.cn/products/db07268.html","C17H15N5O2","Free Base","N/A","NC(=O)C1=CC=CC=C1NC2=NC(=NC=C2)NC3=CC=CC(=C3)O",2.971,3,4,5]
["S6742","Etofenamate","b2","L3000-41","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.",369.34,"30544-47-9","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","http://www.selleck.cn/products/etofenamate.html","C18H18F3NO4","Free Base","N/A","OCCOCCOC(=O)C1=C(NC2=CC=CC(=C2)C(F)(F)F)C=CC=C1",3.507,3,2,10]
["S6744","Inauhzin","c2","L3000-41","in 10mM DMSO","Sirtuin","Epigenetics","Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.",469.58,"309271-94-1",{"v":94,"d":"94.00"},200.18,"<1","N/A","http://www.selleck.cn/products/inauhzin.html","C25H19N5OS2","Free Base","N/A","CCC(SC1=NN=C2C(=N1)[NH]C3=C2C=CC=C3)C(=O)N4C5=C(SC6=CC=CC=C46)C=CC=C5",6.482,4,1,4]
["S6745","JW55","d2","L3000-41","in 10mM DMSO","PARP,Wnt/beta-catenin","Stem Cells & Wnt","JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).",434.49,"664993-53-7",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://www.selleck.cn/products/jw55.html","C25H26N2O5","Free Base","N/A","COC1=CC=C(C=C1)C2(CCOCC2)CNC(=O)C3=CC=C(NC(=O)C4=CC=CO4)C=C3",2.926,5,2,7]
["S6746","APD668","e2","L3000-41","in 10mM DMSO","GPR","Endocrinology & Hormones","APD668 (JNJ28630368) is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively.",477.51,"832714-46-2",{"v":96,"d":"96.00"},201.04,"<1","N/A","http://www.selleck.cn/products/apd668.html","C21H24FN5O5S","Free Base","JNJ28630368","CC(C)OC(=O)N1CCC(CC1)OC2=NC=NC3=C2C=N[N]3C4=CC=C(C=C4F)[S](C)(=O)=O",{"v":2.67,"d":"2.670"},8,0,6]
["S6747","SW-044248","f2","L3000-41","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.",421.52,"522650-83-5",{"v":14,"d":"14.00"},33.21,"<1","N/A","http://www.selleck.cn/products/sw-044248.html","C22H23N5O2S","Free Base","N/A","CCC(SC1=NC2=C(N=N1)C3=CC=CC=C3[N]2CC)C(=O)NC4=CC=CC=C4OC",{"v":4.95,"d":"4.950"},5,1,7]
["S6748","ML364","g2","L3000-41","in 10mM DMSO","DUB","Ubiquitin","ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.",517.54,"1991986-30-1",{"v":50,"d":"50.00"},96.61,"<1","N/A","http://www.selleck.cn/products/ml364.html","C24H18F3N3O3S2","Free Base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=CC=C2C(=O)NC3=NC(=CS3)C4=CC=CC=C4)C(F)(F)F",5.475,4,2,7]
["S6749","ASP-9521","h2","L3000-41","in 10mM DMSO","Dehydrogenase","Metabolism","ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5).",330.42,"1126084-37-4",{"v":66,"d":"66.00"},199.75,"<1","N/A","http://www.selleck.cn/products/asp-9521.html","C19H26N2O3","Free Base","N/A","COC1=CC2=C([NH]C(=C2)C(=O)N3CCC(CC3)CC(C)(C)O)C=C1",2.794,2,1,4]
["S6751","Brevianamide F","a3","L3000-41","in 10mM DMSO","Others","Others","Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..",283.33,"38136-70-8",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://www.selleck.cn/products/brevianamide-f.html","C16H17N3O2","Free Base","N/A","O=C1NC(CC2=C[NH]C3=C2C=CC=C3)C(=O)N4CCCC14",1.255,2,2,2]
["S6752","Y16","b3","L3000-41","in 10mM DMSO","Rho","Cell Cycle","Y16 is an inhibitor of G-protein-coupled Rho GEFs. It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM).",384.43,"429653-73-6",{"v":39,"d":"39.00"},101.45,"<1","N/A","http://www.selleck.cn/products/y16.html","C24H20N2O3","Free Base","N/A","CC1=CC=CC(=C1)COC2=CC=CC(=C2)/C=C/3C(=O)NN(C3=O)C4=CC=CC=C4",4.305,3,1,5]
["S6758","I-CBP112","c3","L3000-41","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","I-CBP112 is a potent and selective CBP/p300 inhibitor with dissociation constant (KD) of 151 ± 6 nM and 167 ± 8 nM for CBP and p300, respectively.",468.59,"1640282-31-0",{"v":94,"d":"94.00"},{"v":200.6,"d":"200.60"},{"v":94,"d":"94.00"},{"v":200.6,"d":"200.60"},"http://www.selleck.cn/products/i-cbp112.html","C27H36N2O5","Free Base","N/A","CCC(=O)N1CCOC2=C(OCC3CCCN(C)C3)C=C(C=C2C1)C4=CC=C(OC)C(=C4)OC",3.796,5,0,7]
["S7716","Pimitespib (TAS-116)","d3","L3000-41","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).",454.53,"1260533-36-5",{"v":91,"d":"91.00"},200.21,"<1","N/A","http://www.selleck.cn/products/tas-116.html","C25H26N8O","Free Base","N/A","CCC1=C(C=CC(=C1)C(N)=O)[N]2N=C(C(C)C)C3=C(C=CN=C23)[N]4C=NC(=C4)C5=C[N](C)N=C5",3.927,5,1,6]
["S8455","Talabostat (PT-100)","e3","L3000-41","in 10mM DMSO","DPP","Proteases","Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.",310.18,"150080-09-4",{"v":62,"d":"62.00"},199.88,{"v":62,"d":"62.00"},199.88,"http://www.selleck.cn/products/talabostat.html","C10H23BN2O6S","Free Base","Val-boroPro","CC(C)C(N)C(=O)N1CCCC1B(O)O.C[S](O)(=O)=O",{"v":0.33,"d":"0.330"},1,1,3]
["S8506","Navarixin (SCH-527123)","f3","L3000-41","in 10mM DMSO","CXCR","Immunology & Inflammation","Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.",397.42,"473727-83-2",{"v":79,"d":"79.00"},198.78,"<1","N/A","http://www.selleck.cn/products/sch-527123.html","C21H23N3O5","Free Base","MK-7123, PS-291822","CCC(NC1=C(NC2=C(O)C(=CC=C2)C(=O)N(C)C)C(=O)C1=O)C3=CC=C(C)O3",1.635,4,3,7]
["S8774","DT-061 (SMAP)","g3","L3000-41","in 10mM DMSO","PP2A","PI3K/Akt/mTOR","DT-061 (SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.",520.52,"1809427-19-7",{"v":100,"d":"100.00"},192.12,"<1","N/A","http://www.selleck.cn/products/dt-061-smap.html","C25H23F3N2O5S","Free Base","N/A","OC1C(CCCC1N2C3=CC=CC=C3OC4=C2C=CC=C4)N[S](=O)(=O)C5=CC=C(OC(F)(F)F)C=C5",6.459,4,2,6]
["S8781","Selpercatinib (LOXO-292)","h3","L3000-41","in 10mM DMSO","c-RET","Apoptosis","Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET (c-RET) inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively.",{"v":525.6,"d":"525.60"},"2152628-33-4",{"v":25,"d":"25.00"},47.56,"<1","N/A","http://www.selleck.cn/products/loxo-292.html","C29H31N7O3","Free Base","ARRY-192","COC1=NC=C(CN2C3CC2CN(C3)C4=NC=C(C=C4)C5=CC(=C[N]6N=CC(=C56)C#N)OCC(C)(C)O)C=C1",2.884,5,0,8]
["S8814","zipalertinib","a4","L3000-41","in 10mM DMSO","EGFR","Angiogenesis","TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.",396.44,"1661854-97-2",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://www.selleck.cn/products/tas6417.html","C23H20N6O","Free Base","CLN-081, TPC-064,TAS6417","CC1=CC(C[N]2C3=NC=NC(=C3C(=C12)C4=CC5=CC=CC=C5N=C4)N)NC(=O)C=C",3.124,4,2,3]
["S8820","Unesbulin (PTC596)","b4","L3000-41","in 10mM DMSO","Apoptosis related,Bcl-2,BMI-1","Cell Cycle","Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.",420.34,"1610964-64-1",{"v":84,"d":"84.00"},199.84,"<1","N/A","http://www.selleck.cn/products/ptc596.html","C19H13F5N6","Free Base","N/A","CC1=NC2=CC=C(F)C=C2[N]1C3=NC(=C(F)C(=N3)N)NC4=CC=C(C=C4)C(F)(F)F",5.366,3,2,4]
["S8828","Gboxin","c4","L3000-41","in 10mM DMSO","ATPase,OXPHOS","Apoptosis","Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. Gboxin inhibits the activity of F0F1 ATP synthase. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.",392.96,"2101315-36-8",{"v":39,"d":"39.00"},99.25,{"v":2,"d":"2.00"},5.09,"http://www.selleck.cn/products/gboxin.html","C22H33ClN2O2","Free Base","N/A","[Cl-].CCC1=[N+](C)C2=CC=CC=C2[N]1CC(=O)OC3CC(C)CCC3C(C)C",3.086,2,0,6]
["S8839","Borussertib","d4","L3000-41","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Borussertib is a covalent-allosteric inhibitor of protein kinase Akt with an IC50 of 0.8 nM and a Ki of 2.2 nM for WT Akt.",596.68,"1800070-77-2",{"v":100,"d":"100.00"},167.59,"<1","N/A","http://www.selleck.cn/products/borussertib.html","C36H32N6O3","Free Base","N/A","C=CC(=O)NC1=CC2=C(NC(=O)N2C3CCN(CC3)CC4=CC=C(C=C4)C5=NC6=C(C=C5C7=CC=CC=C7)C(=O)NC=C6)C=C1",4.051,4,3,7]
["S8843","AZD7648","e4","L3000-41","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases.",{"v":380.4,"d":"380.40"},"2230820-11-6",{"v":6,"d":"6.00"},15.77,"<1","N/A","http://www.selleck.cn/products/azd7648.html","C18H20N8O2","Free Base","N/A","CN1C(=O)N(C2CCOCC2)C3=NC(=NC=C13)NC4=C[N]5N=CN=C5C=C4C",1.059,6,1,3]
["S8847","Orludodstat (BAY 2402234)","f4","L3000-41","in 10mM DMSO","Dehydrogenase","Metabolism","Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.",520.84,"2225819-06-5",{"v":100,"d":"100.00"},{"v":192,"d":"192.00"},"<1","N/A","http://www.selleck.cn/products/bay-2402234.html","C21H18ClF5N4O4","Free Base","N/A","CCN1C(=NN(C1=O)C2=C(F)C=C(C(=O)NC3=C(F)C=CC=C3Cl)C(=C2)OC(C)C(F)(F)F)CO",4.103,4,2,8]
["S8848","Futibatinib (TAS-120)","g4","L3000-41","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","Futibatinib (TAS-120) is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 1.8 nM, 1.4 nM, 1.6 nM and 3.7 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.",418.45,"1448169-71-8",{"v":84,"d":"84.00"},200.74,"<1","N/A","http://www.selleck.cn/products/tas-120.html","C22H22N6O3","Free Base","N/A","COC1=CC(=CC(=C1)C#CC2=N[N](C3CCN(C3)C(=O)C=C)C4=NC=NC(=C24)N)OC",2.402,6,1,6]
["S8853","Belvarafenib (HM95573)","h4","L3000-41","in 10mM DMSO","Raf","MAPK","Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively.",478.93,"1446113-23-0",{"v":96,"d":"96.00"},200.45,"<1","N/A","http://www.selleck.cn/products/belvarafenib.html","C23H16ClFN6OS","Free Base","GDC5573, RG6185","CC1=C(NC(=O)C2=CSC3=C2N=CN=C3N)C4=C(C=C1)C(=NC=C4)NC5=C(F)C(=CC=C5)Cl",5.121,4,3,4]
["S8862","PDD00017273","a5","L3000-41","in 10mM DMSO","PARG","Metabolism","PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with an IC50 of 26 nM. PDD00017273 exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3.",514.62,"1945950-21-9",{"v":100,"d":"100.00"},194.32,"<1","N/A","http://www.selleck.cn/products/pdd00017273.html","C23H26N6O4S2","Free Base","N/A","C[N]1N=C(C)C=C1CN2C(=O)N(CC3=CN=C(C)S3)C(=O)C4=CC(=CC=C24)[S](=O)(=O)NC5(C)CC5",1.554,6,1,7]
["S8865","BAI1","b5","L3000-41","in 10mM DMSO","Bcl-2","Apoptosis","BAI1 is a direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.",{"v":467.2,"d":"467.20"},"335165-68-9",{"v":18,"d":"18.00"},38.53,"<1","N/A","http://www.selleck.cn/products/bai1.html","C19H21Br2N3O","Free Base","N/A","OC(CN1CCNCC1)C[N]2C3=C(C=C(Br)C=C3)C4=C2C=CC(=C4)Br",4.075,0,2,4]
["S8868","NG25","c5","L3000-41","in 10mM DMSO","MAP4K,TAK1","MAPK","NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.",537.58,"1315355-93-1",{"v":100,"d":"100.00"},186.02,"<1","N/A","http://www.selleck.cn/products/ng25.html","C29H30F3N5O2","Free Base","N/A","CCN1CCN(CC1)CC2=CC=C(NC(=O)C3=CC=C(C)C(=C3)OC4=C5C=C[NH]C5=NC=C4)C=C2C(F)(F)F",5.325,3,2,8]
["S8877","Imidazole ketone erastin (PUN30119)","d5","L3000-41","in 10mM DMSO","Ferroptosis","Metabolism","Imidazole ketone erastin (PUN30119, IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis.",655.14,"1801530-11-9",{"v":100,"d":"100.00"},152.64,"<1","N/A","http://www.selleck.cn/products/imidazole-ketone-erastin.html","C35H35ClN6O5","Free Base","IKE","CC(C)OC1=CC=C(C=C1N2C(=NC3=CC=CC=C3C2=O)CN4CCN(CC4)C(=O)COC5=CC=C(Cl)C=C5)C(=O)C[N]6C=CN=C6",4.057,7,0,11]
["S8878","NDI-091143","e5","L3000-41","in 10mM DMSO","ATP-citrate lyase","Metabolism","NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an  IC50 of 2.1 nM in the ADP-Glo assay.",453.84,"2375840-87-0",{"v":91,"d":"91.00"},200.51,"<1","N/A","http://www.selleck.cn/products/ndi-091143.html","C20H14ClF2NO5S","Free Base","N/A","COC(=O)C1=CC(=C(O)C(=C1)[S](=O)(=O)NC2=C(F)C=C(F)C(=C2)C3=CC=CC=C3)Cl",4.524,4,2,6]
["S8895","Ziritaxestat (GLPG1690)","f5","L3000-41","in 10mM DMSO","PDE","Metabolism","Ziritaxestat (GLPG1690) is a selective autotaxin inhibitor with an IC50 of 131 nM and Ki of 15 nM.",{"v":588.7,"d":"588.70"},"1628260-79-6",{"v":100,"d":"100.00"},169.87,"<1","N/A","http://www.selleck.cn/products/ziritaxestat.html","C30H33FN8O2S","Free Base","N/A","CCC1=C(N(C)C2=NC(=C(S2)C#N)C3=CC=C(F)C=C3)[N]4C=C(C=C(C)C4=N1)N5CCN(CC5)CC(=O)N6CC(O)C6",4.314,3,1,7]
["S8899","FF-10101","g5","L3000-41","in 10mM DMSO","FLT3","Angiogenesis","FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.",530.66,"1472797-69-5",{"v":100,"d":"100.00"},188.44,"<1","N/A","http://www.selleck.cn/products/ff-10101.html","C29H38N8O2","Free Base","N/A","CCCNC1=NC(=NC=C1C#CCCCNC(=O)C(C)N(C)C(=O)\\C=C\\CN(C)C)NC2=CC=C(C=C2)C#N",4.153,4,3,15]
["S8901","Taletrectinib (DS-6051b)","h5","L3000-41","in 10mM DMSO","ROS1,Trk receptor","Immunology & Inflammation","Taletrectinib (DS-6051b, AB-106) is a new-generation selective ROS1/NTRK inhibitor with ic50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM for ROS1,NTRK1,NTRK2 and NTRK3,respectively.",551.61,"1505515-69-4",{"v":50,"d":"50.00"},90.64,"<1","N/A","http://www.selleck.cn/products/ds-6051b.html","C29H34FN5O5","Free Base","AB-106","CC(N)COC1=CC=C(C=C1)C2=CN=C3C=CC(=N[N]23)NC(C)C4=CC(=CC=C4)F.OC(=O)CCCCC(O)=O",{"v":2.17,"d":"2.170"},5,2,12]
["S9015","Homoharringtonine (CGX-635)","a6","L3000-41","in 10mM DMSO","STAT","JAK/STAT","Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.",545.62,"26833-87-4",{"v":10,"d":"10.00"},18.33,"N/A","N/A","https://www.selleckchem.com/products/homoharringtonine.html","C29H39NO9","free Base","Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633","COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",2.418,7,0,11]
["S9024","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)","b6","L3000-41","in 10mM DMSO","Lipoxygenase","Metabolism","3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.",512.72,"67416-61-9",{"v":100,"d":"100.00"},195.04,"N/A","N/A","https://www.selleckchem.com/products/akba.html","C32H48O5","Salt","FA42758","CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C",6.081,4,0,3]
["S9050","Boldine","c6","L3000-41","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.",327.37,"476-70-0",{"v":10,"d":"10.00"},30.55,"N/A","N/A","https://www.selleckchem.com/products/boldine.html","C19H21NO4","free base","1, 10-Dimethoxy-2, 9-dihydroxyaporphine; ex Peumus boldus","COC1=C(O)C=C2CC3N(C)CCC4=CC(=C(OC)C(=C34)C2=C1)O",3.083,2,2,2]
["S9086","Dihydrocapsaicin","d6","L3000-41","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.DHC is a selective TRPV1 agonist.",307.43,"19408-84-5",{"v":10,"d":"10.00"},32.53,"N/A","N/A","https://www.selleckchem.com/products/dihydrocapsaicin.html","C18H29NO3","free base","6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589","COC1=C(O)C=CC(=C1)CNC(=O)CCCCCCC(C)C",4.354,2,2,10]
["S9102","Magnolin","e6","L3000-41","in 10mM DMSO","ERK","MAPK","Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).",416.46,"31008-18-1",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/magnolin.html","C23H28O7","free Base","N/A","COC1=C(OC)C=C(C=C1)C2OCC3C2COC3C4=CC(=C(OC)C(=C4)OC)OC",2.618,7,0,7]
["S9110","Morin","f6","L3000-41","in 10mM DMSO","Others","Others","Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.",302.24,"480-16-0",{"v":10,"d":"10.00"},33.09,"N/A","N/A","https://www.selleckchem.com/products/morin.html","C15H10O7","free base","Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum","OC1=CC(=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S9111","Isorhamnetin","g6","L3000-41","in 10mM DMSO","Tyrosinase","Proteases","Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.",316.26,"480-19-3",{"v":63,"d":"63.00"},{"v":199.2,"d":"199.20"},"N/A","N/A","https://www.selleckchem.com/products/isorhamnetin.html","C16H12O7","free base","3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol","COC1=C(O)C=CC(=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",1.856,3,4,2]
["S9123","Eriodictyol","h6","L3000-41","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.",288.25,"552-58-9",{"v":57,"d":"57.00"},197.74,"N/A","N/A","https://www.selleckchem.com/products/eriodictyol.html","C15H12O6","free base","N/A","OC1=CC2=C(C(=O)CC(O2)C3=CC(=C(O)C=C3)O)C(=C1)O",2.131,2,4,1]
["S9183","Ruscogenin","a7","L3000-41","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities.",430.62,"472-11-7",{"v":86,"d":"86.00"},199.71,"N/A","N/A","https://www.selleckchem.com/products/ruscogenin.html","C27H42O4","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(O)CC(O)C6(C)C5CCC4(C)C3C2C",3.408,2,2,0]
["S9192","Vitexin","b7","L3000-41","in 10mM DMSO","Others","Others","Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.",432.38,"3681-93-4",{"v":47,"d":"47.00"},{"v":108.7,"d":"108.70"},"N/A","N/A","https://www.selleckchem.com/products/vitexin.html","C21H20O10","free base","Apigenin-8-C-glucoside","OCC1OC(C(O)C(O)C1O)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=CC=C(O)C=C4",0.018,3,7,3]
["S9224","Dehydroandrographolide Succinate","c7","L3000-41","in 10mM DMSO","Antiviral,Bacterial","Microbiology","Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.",532.58,"786593-06-4",{"v":100,"d":"100.00"},187.77,"N/A","N/A","https://www.selleckchem.com/products/dehydroandrographolide-succinate.html","C28H36O10","free base","N/A","CC1(COC(=O)CCC(O)=O)C(CCC2(C)C1CCC(=C)C2\\C=C\\C3=CCOC3=O)OC(=O)CCC(O)=O",3.027,8,0,13]
["S9248","Homoorientin","d7","L3000-41","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent.",448.38,"4261-42-1",{"v":90,"d":"90.00"},200.72,"N/A","N/A","https://www.selleckchem.com/products/homoorientin.html","C21H20O11","free Base","Isoorientin, Luteolin-6-C-glucoside","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC(=C(O)C=C4)O)C=C2O",-0.224,3,8,3]
["S9270","Dracohodin perochlorate","e7","L3000-41","in 10mM DMSO","Others","Others","Dracohodin perochlorate, extracted from Dragon's blood, is widely used in traditional Chinese medicine, especially in wound healing.",366.75,"125536-25-6",{"v":73,"d":"73.00"},199.05,"N/A","N/A","https://www.selleckchem.com/products/dracohodin-perochlorate.html","C17H15ClO7","free base","N/A","COC1=C(C)C(=CC2=C1C=CC(=[O+]2)C3=CC=CC=C3)O.[O-][Cl](=O)(=O)=O",1.785,1,1,2]
["S9285","Fargesin","f7","L3000-41","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.",{"v":370.4,"d":"370.40"},"31008-19-2",{"v":36,"d":"36.00"},97.19,"N/A","N/A","https://www.selleckchem.com/products/fargesin.html","C21H22O6","free base","N/A","COC1=CC=C(C=C1OC)C2OCC3C2COC3C4=CC5=C(OCO5)C=C4",2.436,6,0,4]
["S9288","Casticin","g7","L3000-41","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.",374.34,"479-91-4",{"v":75,"d":"75.00"},200.35,"N/A","N/A","https://www.selleckchem.com/products/casticin.html","C19H18O8","free base","Vitexicarpin","COC1=C(O)C=C(C=C1)C2=C(OC)C(=O)C3=C(O2)C=C(OC)C(=C3O)OC",2.291,6,2,5]
["S9294","Gelsemine","h7","L3000-41","in 10mM DMSO","GlyR","Transmembrane Transporters","Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., is a highly toxic compound and may be a glycine receptor agonist with significantly higher binding affinity for some of these receptors than its native agonist, glycine.",{"v":322.4,"d":"322.40"},"509-15-9",{"v":64,"d":"64.00"},198.51,"N/A","N/A","https://www.selleckchem.com/products/gelsemine.html","C20H22N2O2","free base","N/A","CN1CC2(C=C)C3CC4OCC3C1C2C45C(=O)NC6=CC=CC=C56",0.891,2,1,1]
["S9416","Triptonide","a8","L3000-41","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.",358.39,"38647-11-9",{"v":71,"d":"71.00"},198.11,"N/A","N/A","https://www.selleckchem.com/products/triptonide.html","C20H22O6","free base","N/A","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2=O",1.259,6,0,1]
["S9519","Fadrozole (CGS16949A)","b8","L3000-41","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.",223.27,"102676-47-1",{"v":45,"d":"45.00"},201.55,"<1","N/A","http://www.selleck.cn/products/fadrozole.html","C14H13N3","Free Base","CGS16949A","N#CC1=CC=C(C=C1)C2CCCC3=CN=C[N]23",2.271,1,0,1]
["S9520","Lasofoxifene Tartrate","c8","L3000-41","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator (SERM) which binds with high affinity to the human estrogen receptor-α with IC50 value of 1.5 nM.",563.64,"190791-29-8",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://www.selleck.cn/products/lasofoxifene-tartrate.html","C32H37NO8","Free Base","N/A","OC(C(O)C(O)=O)C(O)=O.OC1=CC2=C(C=C1)C(C(CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4",1.554,3,3,9]
["S9138","Picfeltarraenin IA","d8","L3000-41","in 10mM DMSO","AChR,Complement System","Neuronal Signaling","Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.",762.92,"97230-47-2",{"v":100,"d":"100.00"},131.07,"N/A","N/A","https://www.selleckchem.com/products/picfeltarraenin-ia.html","C41H62O13","free base","N/A","CC(C)C1=CC(=O)C(C)(O1)C2C(O)CC3(C)C4CC=C5C(CCC(OC6OCC(O)C(O)C6OC7OC(C)C(O)C(O)C7O)C5(C)C)C4(C)C(=O)CC23C",{"v":1.72,"d":"1.720"},7,6,6]
["S9159","momordin-Ic","e8","L3000-41","in 10mM DMSO","SUMO","Ubiquitin","Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.",764.94,"96990-18-0",{"v":100,"d":"100.00"},130.73,"N/A","N/A","https://www.selleckchem.com/products/momordin-ic.html","C41H64O13","free base","N/A","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(O)C(OC7OCC(O)C(O)C7O)C6O)C(O)=O)C(C)(C)C5CCC34C)C2C1)C(O)=O",3.591,6,5,6]
["S1054","AG99","f8","L3000-41","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG99 (Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is a potent and selective inhibitor of EGFR.",204.18,"122520-85-8",{"v":41,"d":"41.00"},{"v":200.8,"d":"200.80"},"<1","N/A","http://www.selleck.cn/products/ag99.html","C10H8N2O3","Free Base","Tyrphostin 46,Tyrphostin A46,Tyrphostin B40","NC(=O)\\C(=C\\C1=CC=C(O)C(=C1)O)C#N",0.655,1,3,2]
["S1058","BI-1347","g8","L3000-41","in 10mM DMSO","CDK","Cell Cycle","BI-1347 is a small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.",356.42,"2163056-91-3",{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://www.selleck.cn/products/bi-1347.html","C22H20N4O","Free Base","N/A","CN(C)C(=O)C[N]1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC4=CC=CC=C34",{"v":2.54,"d":"2.540"},3,0,4]
["S1059","KDM4D-IN-1","h8","L3000-41","in 10mM DMSO","Histone Demethylase","Epigenetics","KDM4D-IN-1 is a potent inhibitor of KDM4D with an IC50 of 0.41 μM.",225.21,"2098902-68-0",{"v":6,"d":"6.00"},26.64,"<1","N/A","http://www.selleck.cn/products/kdm4d-in1.html","C11H7N5O","Free Base","N/A","CC1=N[N]2C(=C1C#N)NC(=O)C3=CC=CN=C23",0.685,3,1,0]
["S1073","BML-210 (CAY10433)","a9","L3000-41","in 10mM DMSO","HDAC","Epigenetics","BML-210 (CAY10433) is a small molecule inhibitor of HDAC.BML-210 inhibits the HDAC4-VP16-driven reporter signal in a dose-dependent manner with an apparent IC50 of ∼5 µM.",339.43,"537034-17-6",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://www.selleck.cn/products/bml210-cay10433.html","C20H25N3O2","Free Base","N/A","NC1=CC=CC=C1NC(=O)CCCCCCC(=O)NC2=CC=CC=C2",3.028,2,3,9]
["S1099","SKLB4771 (FLT3-IN-1)","b9","L3000-41","in 10mM DMSO","FLT3","Angiogenesis","SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM.",537.66,"1370256-78-2",{"v":50,"d":"50.00"},{"v":93,"d":"93.00"},"<1","N/A","http://www.selleck.cn/products/sklb4771-flt3-in1.html","C25H27N7O3S2","Free Base","N/A","CC1=CC=C(NC(=O)NC2=NN=C(S2)SC3=C4C=CC(=CC4=NC=N3)OCCCN5CCOCC5)C=C1",4.112,7,2,9]
["S2002","CZC-25146","c9","L3000-41","in 10mM DMSO","LRRK2","Autophagy","CZC-25146 is a potent and selective LRRK2 inhibitor with IC50 of 4.76 nM and 6.87 nM for human wild type LRRK2 and G2019S LRRK2, respectively.",488.54,"1191911-26-8",{"v":98,"d":"98.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://www.selleck.cn/products/czc-25146.html","C22H25FN6O4S","Free Base","N/A","COC1=CC(=CC=C1NC2=NC=C(F)C(=N2)NC3=CC=CC=C3N[S](C)(=O)=O)N4CCOCC4",3.161,6,3,8]
["S2009","Indirubin-3'-monoxime","d9","L3000-41","in 10mM DMSO","CDK","Cell Cycle","Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.",277.28,"160807-49-8",{"v":55,"d":"55.00"},198.36,"<1","N/A","http://www.selleck.cn/products/indirubin-3-monoxime.html","C16H11N3O2","Free Base","Indirubin-3'-oxime","O/N=C1/C(NC2=C1C=CC=C2)=C3\\C(=O)NC4=C3C=CC=C4",1.943,2,2,0]
["S2070","ISCK03","e9","L3000-41","in 10mM DMSO","c-Kit","Protein Tyrosine Kinase","ISCK03 (N-(4-imidazol-1-yl phenyl)sulfonamide) is a cell-permeable inhibitor of stem-cell factor (SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation.",355.45,"945526-43-2",{"v":71,"d":"71.00"},199.75,"<1","N/A","http://www.selleck.cn/products/isck03.html","C19H21N3O2S","Free Base","N-(4-imidazol-1-yl phenyl)sulfonamide","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(C=C2)[N]3C=CN=C3",3.387,3,1,5]
["S2115","RG 13022","f9","L3000-41","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","RG 13022 (Tyrphostin RG13022) inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with IC50 of 4 µM.",266.29,"136831-48-6",{"v":53,"d":"53.00"},199.03,"<1","N/A","http://www.selleck.cn/products/rg-13022.html","C16H14N2O2","Free Base","Tyrphostin RG13022","COC1=CC=C(C=C1OC)\\C=C(C#N)/C2=CC=CN=C2",2.471,3,0,4]
["S2132","SR-4370","g9","L3000-41","in 10mM DMSO","HDAC","Epigenetics","SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.",304.33,"1816294-67-3",{"v":61,"d":"61.00"},200.44,"<1","N/A","http://www.selleck.cn/products/sr4370.html","C17H18F2N2O","Free Base","N/A","CCCCNNC(=O)C1=CC=C(C=C1)C2=C(F)C(=CC=C2)F",3.804,1,2,6]
["S2184","WDR5-0103","h9","L3000-41","in 10mM DMSO","Histone Methyltransferase,WDR5","Epigenetics","WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.",383.44,"890190-22-4",{"v":77,"d":"77.00"},200.81,"<1","N/A","http://www.selleck.cn/products/wdr5-0103.html","C21H25N3O4","Free Base","WD-Repeat Protein 5-0103","COC(=O)C1=CC=C(N2CCN(C)CC2)C(=C1)NC(=O)C3=CC=CC(=C3)OC",2.573,4,1,6]
["S2210","Sphingosine","a10","L3000-41","in 10mM DMSO","Others","Others","Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.",299.49,"123-78-4",{"v":19,"d":"19.00"},63.44,"<1","N/A","http://www.selleck.cn/products/sphingosine.html","C18H37NO2","Free Base","2-amino-4-trans-octadecene-1,3-diol,C18 Sphingosine","CCCCCCCCCCCCC/C=C/C(O)C(N)CO",4.824,0,3,15]
["S2212","AIM-100","b10","L3000-41","in 10mM DMSO","ACK","Protein Tyrosine Kinase","AIM-100 is a potent small molecule inhibitor of Ack1 with IC50 of 24nM.",371.43,"873305-35-2",{"v":74,"d":"74.00"},199.23,"<1","N/A","http://www.selleck.cn/products/aim-100.html","C23H21N3O2","Free Base","N/A","C1COC(C1)CNC2=NC=NC3=C2C(=C(O3)C4=CC=CC=C4)C5=CC=CC=C5",4.588,4,1,5]
["S2234","BIBF-0775","c10","L3000-41","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM.",494.63,"334951-90-5",{"v":14,"d":"14.00"},{"v":28.3,"d":"28.30"},"<1","N/A","http://www.selleck.cn/products/bibf-0775.html","C31H34N4O2","Free Base","N/A","CCN(C)C(=O)C1=CC2=C(C=C1)\\C(C(=O)N2)=C(\\NC3=CC=C(CN4CCCCC4)C=C3)C5=CC=CC=C5",4.574,2,2,7]
["S2272","Indoprofen","d10","L3000-41","in 10mM DMSO","COX,Others,PDPK1","PI3K/Akt/mTOR","Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein.",281.31,"31842-01-0",{"v":52,"d":"52.00"},184.85,"<1","N/A","http://www.selleck.cn/products/indoprofen.html","C17H15NO3","Free Base","N/A","CC(C(O)=O)C1=CC=C(C=C1)N2CC3=C(C=CC=C3)C2=O",2.701,2,0,3]
["S2307","Roquinimex","e10","L3000-41","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α.",308.33,"84088-42-6",{"v":62,"d":"62.00"},201.08,"<1","N/A","http://www.selleck.cn/products/roquinimex.html","C18H16N2O3","Free Base","FCF 89, Linomide, LS 2616","CN(C1=CC=CC=C1)C(=O)C2=C(O)C3=C(C=CC=C3)N(C)C2=O",1.871,2,1,2]
["S2426","Tirapazamine","f10","L3000-41","in 10mM DMSO","Others","Others","Tirapazamine (NSC 130181, SR 259075, SR 4233, Tirazone, WIN 59075) is a new anticancer drug in solid tumours. Tirapazamine exhibits preferential tumour cell killing and high specific toxicity to cells at low oxygen tensions.",178.15,"27314-97-2",{"v":36,"d":"36.00"},202.08,"<1","N/A","http://www.selleck.cn/products/tirapazamine.html","C7H6N4O2","Free Base","NSC 130181, SR 259075, SR 4233, Tirazone, WIN 59075","NC1=[N+]([O-])C2=CC=CC=C2[N+](=N1)[O-]",-0.565,1,1,0]
["S2465","CPI-1189","g10","L3000-41","in 10mM DMSO","TNF-alpha","Apoptosis","CPI-1189 (REN 1654, REN 1189) is the proapoptotic cytokine tumor necrosis factor (TNF) alpha inhibitor. CPI-1189 intracellularly inhibits the p38 mitogen-activated protein kinase phosphoactivation and shows neuroprotective effects.",234.29,"183619-38-7",{"v":47,"d":"47.00"},200.61,"<1","N/A","http://www.selleck.cn/products/cpi-1189.html","C13H18N2O2","Free Base","REN 1654, REN 1189","CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C",1.089,2,2,3]
["S2643","4-IPP","h10","L3000-41","in 10mM DMSO","MIF","Immunology & Inflammation","4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) and a specific suicide substrate for MIF. 4-IPP can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro.",282.08,"41270-96-6",{"v":56,"d":"56.00"},198.53,"<1","N/A","http://www.selleck.cn/products/4-ipp.html","C10H7IN2","Free Base","4-Iodo-6-phenylpyrimidine","IC1=CC(=NC=N1)C2=CC=CC=C2",3.103,2,0,1]
["S6514","SU5408","a11","L3000-41","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and selective inhibitor of VEGFR2 Kinase with IC50 of 70 nM.",310.35,"15966-93-5",{"v":6,"d":"6.00"},19.33,"<1","N/A","http://www.selleck.cn/products/su5408.html","C18H18N2O3","Free Base","VEGFR2 Kinase Inhibitor I","CCOC(=O)C1=C(C)[NH]C(=C1C)\\C=C2/C(=O)NC3=C2C=CC=C3",2.952,3,2,4]
["S6548","NKL 22","b11","L3000-41","in 10mM DMSO","HDAC","Epigenetics","NKL 22 is a selective inhibitor of HDAC with IC50 of 78 µM.",{"v":325.4,"d":"325.40"},"537034-15-4",{"v":65,"d":"65.00"},199.75,"<1","N/A","http://www.selleck.cn/products/nkl-22.html","C19H23N3O2","Free Base","N/A","NC1=CC=CC=C1NC(=O)CCCCCC(=O)NC2=CC=CC=C2",2.572,2,3,8]
["S6647","Bardoxolone","c11","L3000-41","in 10mM DMSO","Nrf2","Immunology & Inflammation","Bardoxolone (CDDO, RTA 401), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2  that induce programmed cell death (apoptosis) in cancer cells.",491.66,"218600-44-3",{"v":6,"d":"6.00"},{"v":12.2,"d":"12.20"},"<1","N/A","http://www.selleck.cn/products/bardoxolone.html","C31H41NO4","Free Base","CDDO, RTA 401","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C5(C)C=C(C#N)C(=O)C(C)(C)C5CCC34C)C(O)=O",5.573,3,0,1]
["S6649","E7046 (ER-886406)","d11","L3000-41","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","E7046 (ER-886406, Palupiprant, AN0025) is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM.",483.39,"1369489-71-3",{"v":100,"d":"100.00"},206.87,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/e7046.html","C22H18F5N3O4","Free Base","Palupiprant, AN0025","CC(NC(=O)C1=C(OC2=CC=CC(=C2)C(F)(F)F)[N](C)N=C1C(F)F)C3=CC=C(C=C3)C(O)=O",4.787,4,1,8]
["S6651","G15 (GRB-G15)","e11","L3000-41","in 10mM DMSO","Estrogen/progestogen Receptor,GPR,GPR","Endocrinology & Hormones","G15 is a cell-permeable high affinity and selective  G-protein coupled estrogen receptor 1 (GPER, GPR30)  antagonist with an affinity of approximately 20 nM that displays no affinity for ERα and ERβ at concentrations up to 10 μM.",370.24,"1161002-05-6",{"v":74,"d":"74.00"},199.87,"<1","N/A","http://www.selleck.cn/products/g15.html","C19H16BrNO2","Free Base","N/A","BrC1=CC2=C(OCO2)C=C1C3NC4=C(C=CC=C4)C5C=CCC35",4.509,2,1,1]
["S6652","H-151","f11","L3000-41","in 10mM DMSO","STING","Immunology & Inflammation","H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.",279.34,"941987-60-6",{"v":56,"d":"56.00"},200.47,"<1","N/A","http://www.selleck.cn/products/h-151.html","C17H17N3O","Free Base","N/A","CCC1=CC=C(NC(=O)NC2=C[NH]C3=CC=CC=C23)C=C1",3.758,1,3,3]
["S6658","ETC-206 (AUM 001)","g11","L3000-41","in 10mM DMSO","MNK","MAPK","ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively.",408.45,"1464151-33-4",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://www.selleck.cn/products/etc-206.html","C25H20N4O2","Free Base","ETC-1907206","O=C(N1CCOCC1)C2=CC=C(C=C2)C3=C[N]4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3",3.016,3,0,3]
["S6660","B-Raf inhibitor 1 (Compound 13) dihydrochloride","h11","L3000-41","in 10mM DMSO","Raf","MAPK","B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.",551.86,"1191385-19-9",{"v":100,"d":"100.00"},181.21,"<1","N/A","http://www.selleck.cn/products/b-raf-inhibitor-1-dihydrochlorid.html","C26H21Cl3N8","dihydrochloride","N/A","Cl.Cl.CC1=C(NC2=NC=CC=C2C3=C4N=C[NH]C4=NC=N3)C5=CC=NC(=C5C=C1)NC6=CC=C(Cl)C=C6",6.412,5,3,5]
["S6662","AST-487 (NVP-AST487)","a2","L3000-42","in 10mM DMSO","Bcr-Abl,c-Kit,c-RET,FLT3","Angiogenesis","AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.",529.56,"630124-46-8",{"v":100,"d":"100.00"},188.84,"<1","N/A","http://www.selleck.cn/products/ast-487.html","C26H30F3N7O2","Free Base","N/A","CCN1CCN(CC1)CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC=NC(=C4)NC)C=C3)C=C2)C(F)(F)F",4.513,4,3,9]
["S6666","FT113","b2","L3000-42","in 10mM DMSO","Fatty Acid Synthase","Metabolism","FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM.",409.41,"1630808-89-7",{"v":28,"d":"28.00"},68.39,"<1","N/A","http://www.selleck.cn/products/ft113.html","C22H20FN3O4","Free Base","N/A","OC1(CC1)C(=O)N2CCN(CC2)C(=O)C3=CC=C(C=C3)C4=NC5=C(O4)C=C(F)C=C5",2.004,4,0,3]
["S6667","STING inhibitor C-178","c2","L3000-42","in 10mM DMSO","STING","Immunology & Inflammation","C-178 is a covalent inhibitor of STING,covalently bind to Cys91.",322.27,"329198-87-0",{"v":32,"d":"32.00"},{"v":99.3,"d":"99.30"},"<1","N/A","http://www.selleck.cn/products/c-178.html","C17H10N2O5","Free Base","N/A","[O-][N+](=O)C1=CC=C(O1)C(=O)NC2=CC3=C(C=C2)C4=CC=CC=C4O3",3.532,3,1,3]
["S6673","CCG-222740","d2","L3000-42","in 10mM DMSO","Actin,Rho","Cell Cycle","CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.",444.86,"1922098-69-8",{"v":89,"d":"89.00"},200.06,"<1","N/A","http://www.selleck.cn/products/ccg-222740.html","C23H19ClF2N2O3","Free Base","N/A","FC1(F)CC(CN(C1)C(=O)C2=CC(=CC=C2)C3=CC=CO3)C(=O)NC4=CC=C(Cl)C=C4",{"v":3.99,"d":"3.990"},3,1,4]
["S6674","Cytosporone B","e2","L3000-42","in 10mM DMSO","Nur77","Cell Cycle","Cytosporone B  is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.",{"v":322.4,"d":"322.40"},"321661-62-5",{"v":64,"d":"64.00"},198.51,"<1","N/A","http://www.selleck.cn/products/cytosporone-b.html","C18H26O5","Free Base","N/A","CCCCCCCC(=O)C1=C(O)C=C(O)C=C1CC(=O)OCC",4.272,3,2,11]
["S6676","Ebselen","f2","L3000-42","in 10mM DMSO","COVID-19,HIV","Microbiology","Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.",274.18,"60940-34-3",{"v":55,"d":"55.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://www.selleck.cn/products/ebselen.html","C13H9NOSe","Free Base","DR 3305, SPI-1005, PZ-51, CCG-39161","O=C1N([Se]C2=C1C=CC=C2)C3=CC=CC=C3",3.227,1,0,1]
["S6680","L-779450","g2","L3000-42","in 10mM DMSO","Raf","MAPK","L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM.",{"v":347.8,"d":"347.80"},"303727-31-3",{"v":70,"d":"70.00"},201.27,"<1","N/A","http://www.selleck.cn/products/l-779450.html","C20H14ClN3O","Free Base","L-779,450","OC1=CC(=CC=C1Cl)C2=C(N=C([NH]2)C3=CC=CC=C3)C4=CC=NC=C4",{"v":4.67,"d":"4.670"},2,2,3]
["S6689","Merimepodib","h2","L3000-42","in 10mM DMSO","Dehydrogenase,HCV","Metabolism","Merimepodib (Merimempodib, MMPD, VI-21,497, VX-497) is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.",452.46,"198821-22-6",{"v":90,"d":"90.00"},198.91,"<1","N/A","http://www.selleck.cn/products/merimepodib.html","C23H24N4O6","Free Base","Merimempodib; MMPD; VI-21,497; VX-497","COC1=CC(=CC=C1C2=CN=CO2)NC(=O)NC3=CC(=CC=C3)CNC(=O)OC4CCOC4",1.762,7,3,8]
["S6690","TOFA (5-(Tetradecyloxy)-2-furoic acid)","a3","L3000-42","in 10mM DMSO","Acetyl-CoA carboxylase","Metabolism","TOFA (5-(Tetradecyloxy)-2-furoic acid, Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). Inside the cell, TOFA is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner.",324.45,"54857-86-2",{"v":65,"d":"65.00"},200.34,"<1","N/A","http://www.selleck.cn/products/tofa-rmi14514.html","C19H32O4","Free Base","RMI14514, MDL14514","CCCCCCCCCCCCCCOC1=CC=C(O1)C(O)=O",6.853,3,0,15]
["S8500","BAY1125976","b3","L3000-42","in 10mM DMSO","Akt","PI3K/Akt/mTOR","BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).",383.45,"1402608-02-9",{"v":11,"d":"11.00"},28.69,"<1","N/A","http://www.selleck.cn/products/bay1125976.html","C23H21N5O","Free Base","N/A","NC(=O)C1=N[N]2C(=NC(=C2C3=CC=CC=C3)C4=CC=C(C=C4)C5(N)CCC5)C=C1",3.335,3,2,4]
["S8882","ODM-203","c3","L3000-42","in 10mM DMSO","FGFR,VEGFR","Angiogenesis","ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.",505.54,"1430723-35-5",{"v":100,"d":"100.00"},197.81,"<1","N/A","http://www.selleck.cn/products/odm-203.html","C26H21F2N5O2S","Free Base","N/A","C[N]1C=C(C=N1)C2=CC3=C(C=C2)[N](C=N3)C4=CC(=CC(=C4)N[S](=O)(=O)C5CC5)C6=C(F)C=C(F)C=C6",4.626,4,1,6]
["S8904","USP25/28 inhibitor AZ1","d3","L3000-42","in 10mM DMSO","DUB","Ubiquitin","AZ1 is a  potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.",422.21,"2165322-94-9",{"v":84,"d":"84.00"},198.95,"<1","N/A","http://www.selleck.cn/products/usp25-28-inhibitor-az1.html","C17H16BrF4NO2","Free Base","N/A","OCCNCC1=C(OCC2=CC(=C(F)C=C2)C(F)(F)F)C=CC(=C1)Br",4.291,1,2,8]
["S8909","UBCS039","e3","L3000-42","in 10mM DMSO","Sirtuin","Epigenetics","UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.",247.29,"358721-70-7",{"v":49,"d":"49.00"},198.15,"<1","N/A","http://www.selleck.cn/products/ubcs039.html","C16H13N3","Free Base","N/A","N1C(C2=CN=CC=C2)C3=CC=C[N]3C4=CC=CC=C14",2.914,1,1,1]
["S8949","Olutasidenib (FT-2102)","f3","L3000-42","in 10mM DMSO","Dehydrogenase","Metabolism","Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively.",354.79,"1887014-12-1",{"v":71,"d":"71.00"},200.12,"<1","N/A","http://www.selleck.cn/products/olutasidenib-ft-2102.html","C18H15ClN4O2","Free Base","N/A","CC(NC1=CC=C(C#N)N(C)C1=O)C2=CC3=C(NC2=O)C=CC(=C3)Cl",1.234,2,2,3]
["S9044","Ginsenoside F2","g3","L3000-42","in 10mM DMSO","Others","Others","Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.",785.01,"62025-49-4",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleck.cn/products/ginsenoside-f2.html","C42H72O13","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C",2.295,4,9,10]
["S9116","Chikusetsusaponin IVa","h3","L3000-42","in 10mM DMSO","AMPK,Immunology & Inflammation related","Immunology & Inflammation","Chikusetsusaponin IVa (Calenduloside F), a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity. Chikusetsusaponin IVa is a novel AMPK activator.",794.97,"51415-02-2",{"v":100,"d":"100.00"},125.79,{"v":100,"d":"100.00"},125.79,"http://www.selleck.cn/products/chikusetsusaponin-iva.html","C42H66O14","Free Base","Calenduloside F","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(O)C(O)C6O)C(O)=O)C(C)(C)C5CCC34C)C2C1)C(=O)OC7OC(CO)C(O)C(O)C7O",2.898,6,7,7]
["S9117","(20S)Ginsenoside Rg2","a4","L3000-42","in 10mM DMSO","Others","Others","(20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells.",785.01,"52286-74-5",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleck.cn/products/20s-ginsenoside-rg2.html","C42H72O13","Free Base","N/A","CC1OC(OC2C(O)C(O)C(CO)OC2OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(O)CCC=C(C)C)C6(C)CCC(O)C(C)(C)C36)C(O)C(O)C1O",2.014,4,8,9]
["S9131","Punicalagin","b4","L3000-42","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects., Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.",1084.72,"65995-63-3",{"v":100,"d":"100.00"},92.19,{"v":100,"d":"100.00"},92.19,"http://www.selleck.cn/products/punicalagin.html","C48H28O30","Free Base","N/A","OC1COC(=O)C2=CC(=C(O)C(=C2C3=C4C(=O)OC5=C(O)C(=C(C6=C5C4=C(OC6=O)C(=C3O)O)C7=C(C=C(O)C(=C7O)O)C(=O)OC1C8OC(=O)C9=CC(=C(O)C(=C9C%10=C(C=C(O)C(=C%10O)O)C(=O)OC8C=O)O)O)O)O)O",3.128,13,17,2]
["S9144","Solasonine","c4","L3000-42","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.",884.06,"19121-58-5",{"v":100,"d":"100.00"},113.11,"<1","N/A","http://www.selleck.cn/products/solasonine.html","C45H73NO16","Free Base","N/A","CC1CCC2(NC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C7OC9OC(C)C(O)C(O)C9O",0.015,7,10,8]
["S9145","Solamargine","d4","L3000-42","in 10mM DMSO","P-gp","Neuronal Signaling","Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.",868.06,"20311-51-7",{"v":100,"d":"100.00"},{"v":115.2,"d":"115.20"},"<1","N/A","http://www.selleck.cn/products/solamargine.html","C45H73NO15","Free Base","N/A","CC1CCC2(NC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",0.903,7,9,7]
["S9235","Didymin","e4","L3000-42","in 10mM DMSO","p53","Apoptosis","Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.",594.56,"14259-47-3",{"v":100,"d":"100.00"},168.19,{"v":100,"d":"100.00"},168.19,"http://www.selleck.cn/products/didymin.html","C28H34O14","Free Base","Neoponcirin, Isosakuranetin-7-O-rutinoside","COC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O",-0.189,7,7,7]
["S9305","Toosendanin","f4","L3000-42","in 10mM DMSO","Others","Others","Toosendanin, a triterpenoid extracted from Melia toosendan Sieb et Zucc, possesses broad biological actions from blocking neurotransmission and antibotulism to inducing cell differentiation and apoptosis.",574.62,"58812-37-6",{"v":100,"d":"100.00"},174.03,"<1","N/A","http://www.selleck.cn/products/toosendanin.html","C30H38O11","Free Base","N/A","CC(=O)OC1CC(O)C23COC(O)C1(C)C2CC(O)C4(C)C3C(=O)C(OC(C)=O)C5(C)C(CC6OC456)C7=COC=C7",-0.559,8,2,5]
["S0102","L 189","g4","L3000-42","in 10mM DMSO","CRISPR/Cas9,DNA/RNA Synthesis","DNA Damage/DNA Repair","L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.",246.29,"64232-83-3",{"v":49,"d":"49.00"},198.95,"˂1","N/A","http://www.selleckchem.com/products/l-189.html","C11H10N4OS","Free Base","N/A","NC1=C(N=CC2=CC=CC=C2)C(=O)NC(=S)N1",1.163,2,3,2]
["S0103","ML327","h4","L3000-42","in 10mM DMSO","Apoptosis related,Myc","Cell Cycle","ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis.",366.37,"1883510-31-3",{"v":50,"d":"50.00"},136.47,"<1","N/A","http://www.selleckchem.com/products/ml327.html","C19H18N4O4","Free Base","N/A","O=C(NCCCNC(=O)C1=CC=CNC1=O)C2=NOC(=C2)C3=CC=CC=C3",0.455,5,3,7]
["S0108","AZ-33","a5","L3000-42","in 10mM DMSO","Decarboxylase,LDH","Metabolism","AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.",497.56,"1370290-34-8",{"v":100,"d":"100.00"},200.98,"˂1","N/A","http://www.selleckchem.com/products/az-33.html","C25H27N3O6S","Free Base","LDHA Inhibitor 33","CC1=NC2=C(S1)C=C(NC(=O)CCNC(=O)CCCC3=CC=C(CC(C(O)=O)C(O)=O)C=C3)C=C2",2.941,5,2,12]
["S0328","MMAF","b5","L3000-42","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","MMAF (Monomethylauristatin F) is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization. MMAF (Monomethylauristatin F) is applied as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin, ABT-414 and SGN-CD19A.",731.96,"745017-94-1",{"v":100,"d":"100.00"},136.62,{"v":100,"d":"100.00"},136.62,"http://www.selleckchem.com/products/mmaf.html","C39H65N5O8","Free Base","Monomethylauristatin F","CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(CC2=CC=CC=C2)C(O)=O)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C",0.827,7,3,21]
["S0469","ML216","c5","L3000-42","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.",383.32,"1430213-30-1",{"v":38,"d":"38.00"},99.13,"˂1","N/A","http://www.selleckchem.com/products/ml216.html","C15H9F4N5OS","Free Base","CID-49852229","FC1=CC=C(NC(=O)NC2=NN=C(S2)C3=CC=NC=C3)C=C1C(F)(F)F",2.919,4,2,4]
["S0487","Sulfatinib","d5","L3000-42","in 10mM DMSO","CSF-1R,FGFR,VEGFR","Protein Tyrosine Kinase","Sulfatinib (HMPL-012, Sufatinib, Surfatinib, Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1, VEGFR2, VEGFR3, FGFR1 and CSF1R with IC50 of 2 nM, 24 nM, 1 nM, 15 nM and 4 nM, respectively. Sulfatinib shows encouraging antitumor activity and manageable toxicities in patients with advanced NETs.",480.58,"1308672-74-3",{"v":96,"d":"96.00"},199.76,"˂1","N/A","http://www.selleckchem.com/products/sulfatinib.html","C24H28N6O3S","Free Base","HMPL-012, Sufatinib, Surfatinib, Surufatinib","CN(C)CCN[S](=O)(=O)CC1=CC(=CC=C1)NC2=NC=CC(=N2)OC3=CC4=C([NH]C(=C4)C)C=C3",3.717,5,3,10]
["S0788","ML 210","e5","L3000-42","in 10mM DMSO","Ferroptosis,Peroxidases","Metabolism","ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.",475.32,"1360705-96-9",{"v":15,"d":"15.00"},31.56,"<1","N/A","http://www.selleckchem.com/products/ml210.html","C22H20Cl2N4O4","Free Base","CID 49766530","CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)[N+]([O-])=O",4.648,3,0,5]
["S2288","Rubitecan","f5","L3000-42","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.",393.35,"91421-42-0",{"v":58,"d":"58.00"},147.45,"<1","N/A","http://www.selleckchem.com/products/rubitecan.html","C20H15N3O6","Free Base","9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=C(C5=C4)[N+]([O-])=O)C2=O",{"v":1.64,"d":"1.640"},4,0,2]
["S2427","Triglycidyl Isocyanurate (Teroxirone)","g5","L3000-42","in 10mM DMSO","DNA/RNA Synthesis,p53","Apoptosis","Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.",297.26,"2451-62-9",{"v":59,"d":"59.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/triglycidyl-isocyanurat.html","C12H15N3O6","Free Base","Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC","O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4",-0.894,6,0,6]
["S2447","Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)","h5","L3000-42","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.",635.14,"66584-72-3",{"v":100,"d":"100.00"},157.45,"<1","N/A","http://www.selleckchem.com/products/ansamitocin-p-3-maytansinol-isobutyrate.html","C32H43ClN2O9","Free Base","Antibiotic C 15003P3","COC1\\C=C\\C=C(C)\\CC2=CC(=C(Cl)C(=C2)OC)N(C)C(=O)CC(OC(=O)C(C)C)C3(C)OC3C(C)C4CC1(O)NC(=O)O4",4.445,8,1,5]
["S2477","2'-Deoxy-5-Fluorocytidine","a6","L3000-42","in 10mM DMSO","DNA Methyltransferase","Endocrinology & Hormones","2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors.",245.21,"10356-76-0",{"v":49,"d":"49.00"},199.83,{"v":12,"d":"12.00"},48.94,"http://www.selleckchem.com/products/2-feoxy-5-fluorocytidine.html","C9H12FN3O4","Free Base","5-fluoro-2(')-deoxycytidine, FCdR","NC1=NC(=O)N(C=C1F)C2CC(O)C(CO)O2",{"v":-1.72,"d":"-1.720"},3,3,2]
["S2650","RN-1734","b6","L3000-42","in 10mM DMSO","TRP Channel","Transmembrane Transporters","RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.",353.31,"946387-07-1",{"v":71,"d":"71.00"},200.96,"<1","N/A","http://www.selleckchem.com/products/rn-1734.html","C14H22Cl2N2O2S","Free Base","TRPV4 Antagonist I","CC(C)NCCN(C(C)C)[S](=O)(=O)C1=CC=C(Cl)C=C1Cl",3.331,2,1,7]
["S6722","Seclidemstat (SP-2577)","c6","L3000-42","in 10mM DMSO","LSD1","Methylation","Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.",450.94,"1423715-37-0",{"v":90,"d":"90.00"},199.58,"˂1","N/A","http://www.selleckchem.com/products/seclidemstat.html","C20H23ClN4O4S","Free Base","SP-2577 mesylate","CN1CCN(CC1)[S](=O)(=O)C2=CC=CC(=C2)C(=O)N\\N=C(C)\\C3=C(O)C=CC(=C3)Cl",{"v":2.16,"d":"2.160"},4,2,5]
["S6777","NSC95397","d6","L3000-42","in 10mM DMSO","CDK,phosphatase","Metabolism","NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.",310.39,"93718-83-3",{"v":62,"d":"62.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/nsc95397.html","C14H14O4S2","Free Base","N/A","OCCSC1=C(SCCO)C(=O)C2=C(C=CC=C2)C1=O",1.171,2,2,6]
["S6778","TM5441","e6","L3000-42","in 10mM DMSO","PAI-1","Metabolism","TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 ranging between 9.7 μM and 60.3 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines.",428.82,"1190221-43-2",{"v":86,"d":"86.00"},200.55,"<1","N/A","http://www.selleckchem.com/products/tm5441.html","C21H17ClN2O6","Free Base","N/A","OC(=O)C1=C(NC(=O)COCC(=O)NC2=CC=CC(=C2)C3=COC=C3)C=CC(=C1)Cl",2.239,5,2,8]
["S6790","Ellipticine hydrochloride","f6","L3000-42","in 10mM DMSO","Others,P450 (e.g. CYP17),Topoisomerase","Metabolism","Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.",282.77,"5081-48-1",{"v":3,"d":"3.00"},10.61,"˂1","N/A","http://www.selleckchem.com/products/ellipticine-hydrochloride.html","C17H15ClN2","Hydrochloride","NSC 71795 hydrochloride, PZE","Cl.CC1=C2C=CN=CC2=C(C)C3=C1[NH]C4=CC=CC=C34",4.435,1,1,0]
["S6799","DIM-C-pPhOH","g6","L3000-42","in 10mM DMSO","Nur77","Cell Cycle","DIM-C-pPhOH (C-DIM8, CDIM8) is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.",{"v":338.4,"d":"338.40"},"151358-47-3",{"v":68,"d":"68.00"},200.95,"<1","N/A","http://www.selleckchem.com/products/dim-c-pphoh.html","C23H18N2O","Free Base","C-DIM8, CDIM8","OC1=CC=C(C=C1)C(C2=C[NH]C3=C2C=CC=C3)C4=C[NH]C5=C4C=CC=C5",5.433,0,3,3]
["S6805","Tyrphostin AG-528","h6","L3000-42","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Tyrphostin AG-528 (Tyrphostin B66) is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.",306.32,"133550-49-9",{"v":61,"d":"61.00"},199.14,"˂1","N/A","http://www.selleckchem.com/products/tyrphostin-ag-528.html","C18H14N2O3","Free Base","Tyrphostin B66, AG 528","OC1=C(O)C=C(C=C1)/C=C(C#N)/C(=O)N2CCC3=C2C=CC=C3",2.718,1,2,2]
["S6813","Mobocertinib (TAK788)","a7","L3000-42","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Mobocertinib (TAK788, AP32788), an investigational TKI, is a potent, selective preclinical inhibitor of epidermal growth factor receptor (EGFR) and HER2 mutations. Mobocertinib (TAK788) is an antineoplastic agent.",{"v":585.7,"d":"585.70"},"1847461-43-1",{"v":9,"d":"9.00"},15.37,"<1","N/A","http://www.selleckchem.com/products/tak788.html","C32H39N7O4","Free Base","AP32788","COC1=C(NC2=NC=C(C(=O)OC(C)C)C(=N2)C3=C[N](C)C4=CC=CC=C34)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",5.252,6,2,13]
["S6819","Luminol","b7","L3000-42","in 10mM DMSO","Dyes","Others","Luminol (Diogenes reagent, 3-Aminophthalhydrazide) is a versatile chemical exhibiting chemiluminescence with a blue glow, when mixed with an appropriate oxidizing agent. Luminol is uesed in forensic investigations to detect trace amounts of blood at crime scenes and in biological researches to detect copper, iron, and cyanides, as well as specific proteins by western blot. Luminol recently displayes promising applications for the treatment of cancer in deep tissues.",177.16,"521-31-3",{"v":35,"d":"35.00"},197.56,"<1","N/A","http://www.selleckchem.com/products/luminol.html","C8H7N3O2","Free Base","Diogenes reagent, 3-Aminophthalhydrazide","NC1=CC=CC2=C1C(=O)NNC2=O",-0.706,2,3,0]
["S6833","BCI-121","c7","L3000-42","in 10mM DMSO","SMYD","Methylation","BCI-121 is a potent inhibitor of SMYD3 that impairs the proliferation of many kinds of cancer cells.",340.22,"432529-82-3",{"v":68,"d":"68.00"},199.87,"˂1","N/A","http://www.selleckchem.com/products/bcl-121.html","C14H18BrN3O2","Free Base","N/A","NC(=O)C1CCN(CC1)CC(=O)NC2=CC=C(Br)C=C2",1.179,2,2,4]
["S6838","BCTC","d7","L3000-42","in 10mM DMSO","TRP Channel","Transmembrane Transporters","BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.",372.89,"393514-24-4",{"v":74,"d":"74.00"},198.45,"˂1","N/A","http://www.selleckchem.com/products/bctc.html","C20H25ClN4O","Free Base","N/A","CC(C)(C)C1=CC=C(NC(=O)N2CCN(CC2)C3=NC=CC=C3Cl)C=C1",4.234,2,1,3]
["S6843","Vorolanib","e7","L3000-42","in 10mM DMSO","PDGFR,VEGFR","Protein Tyrosine Kinase","Vorolanib (X-82,CM082) is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.",{"v":439.4,"d":"439.40"},"1013920-15-4",{"v":89,"d":"89.00"},202.55,"˂1","N/A","http://www.selleckchem.com/products/vorolanib.html","C23H26FN5O3","Free Base","X-82,CM082","CN(C)C(=O)N1CCC(C1)NC(=O)C2=C(C)[NH]C(=C2C)\\C=C\\3C(=O)NC4=C3C=C(F)C=C4",1.671,3,3,3]
["S6848","3'-Fluoro-3'-deoxythymidine (Alovudine)","f7","L3000-42","in 10mM DMSO","DNA/RNA Synthesis,HIV,Reverse Transcriptase","Microbiology","3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the  chemotherapy of pancreatic cancer.",244.22,"25526-93-6",{"v":49,"d":"49.00"},200.64,{"v":20,"d":"20.00"},81.89,"http://www.selleckchem.com/products/3-fluoro-3-deoxythymidine.html","C10H13FN2O4","Free Base","CL 184824, FddThd, FLT, MIV-310","CC1=CN(C2CC(F)C(CO)O2)C(=O)NC1=O",-0.298,3,2,2]
["S7688","Ki20227","g7","L3000-42","in 10mM DMSO","c-Kit,CSF-1R,PDGFR,VEGFR","Protein Tyrosine Kinase","Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase(CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR-2), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor beta (PDGFRβ), respectively.",480.54,"623142-96-1",{"v":96,"d":"96.00"},199.78,"˂1","N/A","http://www.selleckchem.com/products/ki20227.html","C24H24N4O5S","Free Base","KI-20227","COC1=C(NC(=O)NC(C)C2=NC=CS2)C=CC(=C1)OC3=C4C=C(OC)C(=CC4=NC=C3)OC",{"v":3.36,"d":"3.360"},7,2,8]
["S7821","Bufalin","h7","L3000-42","in 10mM DMSO","ATPase,Others","Transmembrane Transporters","Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.",386.52,"465-21-4",{"v":78,"d":"78.00"},{"v":201.8,"d":"201.80"},"˂1","N/A","http://www.selleckchem.com/products/bufalin.html","C24H34O4","Free Base","BF","CC12CCC(O)CC1CCC3C2CCC4(C)C(CCC34O)C5=COC(=O)C=C5",3.313,2,1,1]
["S7862","Rottlerin","a8","L3000-42","in 10mM DMSO","PKC","TGF-beta/Smad","Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ(from baculovirus-infected Sf9 insect cells), PKCδ(from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.",516.54,"82-08-6",{"v":11,"d":"11.00"},{"v":21.3,"d":"21.30"},"˂1","N/A","http://www.selleckchem.com/products/rottlerin.html","C30H28O8","Free Base","Mallotoxin, NSC 56346, NSC 94525","CC(=O)C1=C(O)C(=C(O)C(=C1O)C)CC2=C(O)C(=C3OC(C)(C)C=CC3=C2O)C(=O)\\C=C\\C4=CC=CC=C4",{"v":5.48,"d":"5.480"},3,5,6]
["S7969","THZ2","b8","L3000-42","in 10mM DMSO","CDK","Cell Cycle","THZ2, a THZ1 analog, is a selective inhibitor of CDK7 with IC50 of 13.9 nM. THZ2 efficiently suppresses the clonogenic growth of TNBC cells with IC50 of ~10 nM.",566.05,"1604810-84-5",{"v":100,"d":"100.00"},176.66,"˂1","N/A","http://www.selleckchem.com/products/thz2.html","C31H28ClN7O2","Free Base","N/A","CN(C)C\\C=C\\C(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=CC=CC=C45",5.619,4,4,9]
["S8784","PQR620","c8","L3000-42","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.",445.47,"1927857-56-4",{"v":20,"d":"20.00"},{"v":44.9,"d":"44.90"},"˂1","N/A","http://www.selleckchem.com/products/pqr620.html","C21H25F2N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3C4CCC3COC4)N5C6CCC5COC6)C(=C1)C(F)F",2.434,6,1,4]
["S8876","RK-287107","d8","L3000-42","in 10mM DMSO","PARP","DNA Damage/DNA Repair","RK-287107 is a novel, potent and selective tankyrase inhibitor with antitumor activity. RK-287107 inhibits tankyrase-1 and tankyrase-2 in vitro with IC50 of 14.3 nM and 10.6 nM.",416.46,"2171386-10-8",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"˂1","N/A","http://www.selleckchem.com/products/pk-287107.html","C22H26F2N4O2","Free Base","N/A","OCCN1CC2(CCN(CC2)C3=NC4=C(CCCC4)C(=O)N3)C5=C1C=C(F)C=C5F",2.731,2,2,3]
["S8883","LLY-283","e8","L3000-42","in 10mM DMSO","PRMT","Methylation","LLY-283 is a novel and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). LLY-283 inhibits PRMT5 enzymatic activity in vitro and in cells with IC50 of 22 nM and 25 nM, respectively. LLY-283 shows antitumor activity.",342.35,"2040291-27-6",{"v":68,"d":"68.00"},198.63,{"v":5,"d":"5.00"},{"v":14.6,"d":"14.60"},"http://www.selleckchem.com/products/lly-283.html","C17H18N4O4","Free Base","N/A","NC1=NC=NC2=C1C=C[N]2C3OC(C(O)C3O)C(O)C4=CC=CC=C4",0.509,3,4,3]
["S8885","UT-34","f8","L3000-42","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","UT-34 is a potent, selective and orally bioavailable second-generation androgen receptor (AR) pan antagonist and degrader with IC50 of 203.46 nM, 80.78 nM and 94.17 nM for wild-type, T877A and W741L AR, respectively. UT-34 is a potential next-generation therapeutic for enzalutamide-resistant prostate cancer.",356.27,"2168525-92-4",{"v":71,"d":"71.00"},199.29,"<1","N/A","http://www.selleckchem.com/products/ut-34.html","C15H12F4N4O2","Free Base","N/A","CC(O)(C[N]1C=C(F)C=N1)C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F",{"v":2.05,"d":"2.050"},2,1,5]
["S8889","MZ-1","g8","L3000-42","in 10mM DMSO","Epigenetic Reader Domain,PROTAC","Epigenetics","MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4). MZ-1 binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2BD1, Brd2BD2, Brd3BD1, Brd3BD2, Brd4BD1 and Brd4BD2.",1002.64,"1797406-69-9",{"v":100,"d":"100.00"},99.74,"<1","N/A","http://www.selleckchem.com/products/mz-1.html","C49H60ClN9O8S2","Free Base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(O)CC4C(=O)NCC5=CC=C(C=C5)C6=C(C)N=CS6)C(C)(C)C)N=C2C7=CC=C(Cl)C=C7)C",3.605,11,4,21]
["S8892","JHU395","h8","L3000-42","in 10mM DMSO","Glutaminase","Proteases","JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.",447.48,"2079938-92-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/jhu395.html","C22H29N3O7","Free Base","N/A","CC(C)OC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)OC(OC(=O)C(C)(C)C)C1=CC=CC=C1",4.148,7,1,14]
["S8894","SR-4835","a9","L3000-42","in 10mM DMSO","CDK","Cell Cycle","SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.",499.36,"2387704-62-1",{"v":100,"d":"100.00"},200.26,"<1","N/A","http://www.selleckchem.com/products/sr-4835.html","C21H20Cl2N10O","Free Base","N/A","C[N]1C=C(C=N1)[N]2C=NC3=C2N=C(N=C3NCC4=NC5=C([NH]4)C=C(Cl)C(=C5)Cl)N6CCOCC6",3.538,6,2,5]
["S8900","SR18662","b9","L3000-42","in 10mM DMSO","KLF","MAPK","SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis.",420.31,"2505001-62-5",{"v":84,"d":"84.00"},199.85,"<1","N/A","http://www.selleckchem.com/products/sr18662.html","C16H19Cl2N3O4S","Free Base","N/A","C[S](=O)(=O)N1CCN(CC1)C(=O)CNC(=O)/C=C/C2=CC(=C(Cl)C=C2)Cl",1.108,4,1,5]
["S8915","C75 trans","c9","L3000-42","in 10mM DMSO","Fatty Acid Synthase","Metabolism","C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.",254.32,"191282-48-1",{"v":51,"d":"51.00"},200.53,"<1","N/A","http://www.selleckchem.com/products/c75.html","C14H22O4","Free Base","trans-C75, (±)-C75","CCCCCCCCC1OC(=O)C(=C)C1C(O)=O",3.711,3,0,8]
["S8922","TBK1/IKKε-IN-1(compound 1)","d9","L3000-42","in 10mM DMSO","IκB/IKK,TBK1","NF-κB","TBK1/IKKε-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and  IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.",513.59,"1893397-65-3",{"v":10,"d":"10.00"},19.47,"˂1","N/A","http://www.selleckchem.com/products/tbk1-IKKe-in-1-compound1.html","C28H31N7O3","Free Base","N/A","N#CC1=CC(=CC=C1OC2CCOCC2)C3=NC=NC(=N3)NC4=CC=C(C=C4)N5CCN(CC5)C6COC6",3.176,6,1,7]
["S8933","ONO-7475","e9","L3000-42","in 10mM DMSO","Axl,Mertk","Protein Tyrosine Kinase","ONO-7475 is a potent, selective, and orally active novel inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 of 0.7 nM and 1.0 nM for AXL and MER, respectively. ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells. ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells.",562.57,"1646839-59-9",{"v":100,"d":"100.00"},177.76,"<1","N/A","http://www.selleckchem.com/products/ono-7475.html","C32H26N4O6","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CN=C(NC(=O)C4=CC5=C(CCCC5=O)N(C4=O)C6=CC=CC=C6)C=C3",3.872,8,1,7]
["S8943","VLX600","f9","L3000-42","in 10mM DMSO","Autophagy,Mitochondrial Metabolism,OXPHOS","Apoptosis","VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.",317.35,"327031-55-0",{"v":13,"d":"13.00"},40.96,"˂1","N/A","http://www.selleckchem.com/products/vlx600.html","C17H15N7","Free Base","N/A","CC1=C2[NH]C3=NC(=NN=C3C2=CC=C1)N\\N=C(C)/C4=CC=CC=N4",3.589,5,2,3]
["S8945","BAY-1816032","g9","L3000-42","in 10mM DMSO","Serine/threonin kinase","Metabolism","BAY-1816032 is a potent and oral available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase with IC50 of 6.1 nM for recombinant catalytic domain of human BUB1. BAY-1816032 has antitumor activity.",534.51,"1891087-61-8",{"v":50,"d":"50.00"},93.54,"<1","N/A","http://www.selleckchem.com/products/bay-1816032.html","C27H24F2N6O4","Free Base","N/A","COC1=C(NC2=NC(=NC=C2OC)C3=N[N](CC4=C(F)C=C(OCCO)C=C4F)C5=C3C=CC=C5)C=CN=C1",4.294,7,2,10]
["S8947","SX-682","h9","L3000-42","in 10mM DMSO","CXCR","Immunology & Inflammation","SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.",{"v":467.2,"d":"467.20"},"1648843-04-2",{"v":93,"d":"93.00"},199.06,"˂1","N/A","http://www.selleckchem.com/products/sx-682.html","C19H14BF4N3O4S","Free Base","N/A","OB(O)C1=CC=C(OC(F)(F)F)C=C1CSC2=NC=C(C=N2)C(=O)NC3=CC=C(F)C=C3",5.761,4,1,8]
["S8953","ASP4132","a10","L3000-42","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.",937.06,"1640294-30-9",{"v":100,"d":"100.00"},106.72,"<1","N/A","http://www.selleckchem.com/products/asp4132.html","C46H51F3N6O8S2","Free Base","N/A","COC1=NC=C(CN2CCC(CC2)C3=CC=C4[NH]C(=NC4=C3)C(=O)N5CCN(CC5)CC6=CC=C(C=C6)C(F)(F)F)C=C1.CC7=CC=C(C=C7)[S](O)(=O)=O.CC8=CC=C(C=C8)[S](O)(=O)=O",8.594,4,1,10]
["S8961","Alobresib (GS-5829)","b10","L3000-42","in 10mM DMSO","Akt,Apoptosis related,Epigenetic Reader Domain,ERK,Myc,NF-κB","Epigenetics","Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Alobresib (GS-5829) inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. Alobresib (GS-5829) also inhibits NF-κB signaling.",437.49,"1637771-14-2",{"v":87,"d":"87.00"},198.86,"˂1","N/A","http://www.selleckchem.com/products/alobresib.html","C26H23N5O2","Free Base","N/A","CC1=C(C(=NO1)C)C2=CC(=C3N=C([NH]C3=C2)C4CC4)C(O)(C5=CC=CC=N5)C6=CC=CC=N6",3.767,5,1,5]
["S8963","HLM006474","c10","L3000-42","in 10mM DMSO","CDK","Cell Cycle","HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 µM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.",399.48,"353519-63-8",{"v":10,"d":"10.00"},25.03,"˂1","N/A","http://www.selleckchem.com/products/hlm006474.html","C25H25N3O2","Free Base","N/A","CCOC1=C(C)C=C(C=C1)C(NC2=CC=CC=N2)C3=C(O)C4=C(C=CC(=N4)C)C=C3",5.268,3,2,6]
["S8995","BAY 2416964","d10","L3000-42","in 10mM DMSO","AhR","Metabolism","BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.",387.82,"2242464-44-2",{"v":78,"d":"78.00"},201.12,"<1","N/A","http://www.selleckchem.com/products/bay-2416964.html","C18H18ClN5O3","Free Base","N/A","CC(CO)NC(=O)C1=CC(=NN(C1=O)C2=C[N](C)N=C2)C3=CC=C(Cl)C=C3",{"v":1.55,"d":"1.550"},4,2,5]
["S0085","BMS-813160","e10","L3000-42","in 10mM DMSO","CCR","Immunology & Inflammation","BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.",484.64,"1286279-29-5",{"v":97,"d":"97.00"},200.15,"<1","N/A","http://www.selleckchem.com/products/bms813160.html","C25H40N8O2","free base","N/A","CC(=O)NC1CC(CCC1N2CCC(NC3=NC=NC4=CC(=N[N]34)C(C)(C)C)C2=O)NC(C)(C)C",1.774,5,3,7]
["S0094","SR 0987","f10","L3000-42","in 10mM DMSO","Interleukins,PD-1/PD-L1,ROR","Immunology & Inflammation","SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer.",{"v":397.7,"d":"397.70"},"303126-97-8",{"v":80,"d":"80.00"},201.16,"<1","N/A","http://www.selleckchem.com/products/sr0987.html","C16H10ClF6NO2","free base","N/A","OC(C1=CC=C(NC(=O)C2=CC=CC=C2Cl)C=C1)(C(F)(F)F)C(F)(F)F",4.574,1,1,5]
["S0135","JMS-17-2","g10","L3000-42","in 10mM DMSO","GPR","GPCR & G Protein","JMS-17-2 is a potent and selective small-molecule antagonist of CX3C chemokine receptor 1 (CX3CR1/GPR13) with IC50 of 0.32 nM. JMS-17-2 is used in the research of  metastatic disease in breast cancer patients.",419.95,"1380392-05-1",{"v":40,"d":"40.00"},95.25,"<1","N/A","http://www.selleckchem.com/products/jms-17-2.html","C25H26ClN3O","free base","N/A","ClC1=CC=C(C=C1)C2CCN(CCCN3C(=O)C4=CC=C[N]4C5=CC=CC=C35)CC2",5.224,1,0,5]
["S0225","IMR-1A","h10","L3000-42","in 10mM DMSO","Notch","Neuronal Signaling","IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.",325.36,"331862-41-0",{"v":6,"d":"6.00"},18.44,"<1","N/A","http://www.selleckchem.com/products/imr-1a.html","C13H11NO5S2","free base","N/A","COC1=CC(=CC=C1OCC(O)=O)\\C=C/2SC(=S)NC2=O",{"v":2.29,"d":"2.290"},4,1,5]
["S0407","XCT790","a11","L3000-42","in 10mM DMSO","Apoptosis related,Estrogen/progestogen Receptor","Endocrinology & Hormones","XCT-790 (Compound 12) is a potent and selective inverse agonist for estrogen-related receptor α (ERRα) with IC50 of 0.37 μM. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ. XCT-790 (Compound 12) significantly inhibits in vivo tumor growth and angiogenesis, and induces apoptosis.",596.42,"725247-18-7",{"v":8,"d":"8.00"},13.41,"<1","N/A","http://www.selleckchem.com/products/xct-790.html","C23H13F9N4O3S","free base","Compound 12","COC1=CC(=CC=C1OCC2=C(C=C(C=C2)C(F)(F)F)C(F)(F)F)\\C=C(C#N)\\C(=O)NC3=NN=C(S3)C(F)(F)F",6.179,5,1,10]
["S0444","Indibulin","b11","L3000-42","in 10mM DMSO","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.",389.83,"204205-90-3",{"v":40,"d":"40.00"},102.61,"<1","N/A","http://www.selleckchem.com/products/Indibulin.html","C22H16ClN3O2","free base","ZIO 301, D 24851, Zybulin","ClC1=CC=C(C[N]2C=C(C(=O)C(=O)NC3=CC=NC=C3)C4=CC=CC=C24)C=C1",4.097,3,1,5]
["S0445","SC-43","c11","L3000-42","in 10mM DMSO","Apoptosis related,phosphatase,STAT","Metabolism","SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.",{"v":431.8,"d":"431.80"},"1400989-25-4",{"v":86,"d":"86.00"},199.17,"<1","N/A","http://www.selleckchem.com/products/sc-43.html","C21H13ClF3N3O2","free base","N/A","FC(F)(F)C1=CC(=CC=C1Cl)NC(=O)NC2=CC=CC(=C2)OC3=CC=C(C=C3)C#N",5.568,2,2,5]
["S0790","CADD522","d11","L3000-42","in 10mM DMSO","RUNX","Cell Cycle","CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA binding with IC50 of 10 nM. CADD522 exhibits anticancer activity.",326.17,"199735-88-1",{"v":65,"d":"65.00"},199.28,"<1","N/A","http://www.selleckchem.com/products/cadd522.html","C15H13Cl2NO3","free base","N/A","OC(=O)C1C2CC(C=C2)C1C(=O)NC3=CC(=C(Cl)C=C3)Cl",2.821,2,1,3]
["S0818","STAT3-IN-1","e11","L3000-42","in 10mM DMSO","STAT","JAK/STAT","STAT3-IN-1 (compound 7d)  is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.",475.53,"2059952-75-7",{"v":95,"d":"95.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/stat3-in-1.html","C28H29NO6","free base","N/A","COC1=CC(=CC(=C1)OC)\\C=C\\C2=CC=C(NC(=O)\\C=C\\C3=CC(=C(OC)C(=C3)OC)OC)C=C2",4.986,6,1,10]
["S0853","SR-717 lithium","f11","L3000-42","in 10mM DMSO","STING","Immunology & Inflammation","SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.",351.19,"2375421-09-1",{"v":40,"d":"40.00"},{"v":113.9,"d":"113.90"},"<1","N/A","http://www.selleckchem.com/products/sr-717.html","C15H8F2LiN5O3","free base","N/A","[Li]OC(=O)C1=C(NC(=O)C2=NN=C(C=C2)[N]3C=CN=C3)C=C(F)C(=C1)F",1.765,6,1,5]
["S0906","6-Methoxydihydrosanguinarine","g11","L3000-42","in 10mM DMSO","Bacterial","Immunology & Inflammation","6-Methoxydihydrosanguinarine is an lkaloid isolated from the fruits of M.cordata. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.",363.36,"72401-54-8",{"v":73,"d":"73.00"},{"v":200.9,"d":"200.90"},"<1","N/A","https://www.selleckchem.com/products/6-methoxydihydroavicine.html","C21H17NO5","free base","6-Methoxy Dihydrosanguinarine","COC1N(C)C2=C(C=CC3=C2C=C4OCOC4=C3)C5=CC6=C(OCO6)C=C15",3.777,5,0,1]
["S1001","Navitoclax (ABT-263)","h11","L3000-42","in 10mM DMSO","Bcl-2","Apoptosis","Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.",974.61,"923564-51-6",{"v":100,"d":"100.00"},102.61,"<1","N/A","http://www.selleckchem.com/products/ABT-263.html","C47H55ClF3N5O6S3","free base","N/A","CC1(C)CCC(=C(CN2CCN(CC2)C3=CC=C(C=C3)C(=O)N[S](=O)(=O)C4=CC(=C(NC(CCN5CCOCC5)CSC6=CC=CC=C6)C=C4)[S](=O)(=O)C(F)(F)F)C1)C7=CC=C(Cl)C=C7",10.495,6,2,17]
["S2440","Vindesine sulfate","a2","L3000-43","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.",{"v":852,"d":"852.00"},"59917-39-4",{"v":100,"d":"100.00"},117.37,{"v":100,"d":"100.00"},117.37,"http://www.selleckchem.com/products/vindesine-sulfate.html","C43H57N5O11S","sulfate","Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(N)=O)C1.O[S](O)(=O)=O",3.047,4,3,7]
["S3215","2-O-α-D-Glucopyranosyl-L-ascorbic acid","b2","L3000-43","in 10mM DMSO","Others","Others","2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G), which is a glucoside derivative of ascorbic acid (AA), shows vitamin C activity after enzymatic hydrolysis to ascorbic acid. The antitumor activity of AA-2G is caused by ROS generated by AA released by rapid hydrolysis of AA-2G.",338.26,"129499-78-1",{"v":68,"d":"68.00"},201.03,{"v":68,"d":"68.00"},201.03,"http://www.selleckchem.com/products/2-o-a-d-glucopyranosyl-l-ascorbic-acid.html","C12H18O11","free base","AA-2G, 2-OaD-Glucopyranosyl-L-ascorbic acid, 2-O-alpha-D-Glucopyranosyl-L-ascorbic Acid, Ascorbic acid 2-glucoside, Ascorbyl glucoside","OCC(O)C1OC(=O)C(=C1O)OC2OC(CO)C(O)C(O)C2O",-3.639,4,7,5]
["S3224","Cinobufagin","c2","L3000-43","in 10mM DMSO","Akt,Apoptosis related,ATM/ATR,Bcl-2,Caspase,CDK,Chk,PI3K","Cell Cycle","Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT  and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.",442.54,"470-37-1",{"v":100,"d":"100.00"},225.97,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cinobufagin.html","C26H34O6","free base","Cinobufagine","CC(=O)OC1C2OC23C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C6=COC(=O)C=C6",2.593,5,1,3]
["S3227","5,7-Dimethoxyflavone","d2","L3000-43","in 10mM DMSO","BCRP,P450 (e.g. CYP17)","Metabolism","5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.",282.29,"21392-57-4",{"v":100,"d":"100.00"},354.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/5-7-dimethoxyflavone.html","C17H14O4","free base","5,7-DMF","COC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)OC",3.103,4,0,3]
["S3235","Sinapine","e2","L3000-43","in 10mM DMSO","P-gp","Transmembrane Transporters","Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.",310.36,"18696-26-9",{"v":100,"d":"100.00"},322.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/sinapine.html","C16H24NO5","free base","N/A","COC1=C(O)C(=CC(=C1)\\C=C\\C(=O)OCC[N+](C)(C)C)OC",0.662,4,1,8]
["S3238","Resibufogenin","f2","L3000-43","in 10mM DMSO","Akt,Apoptosis related,Bcl-2,Caspase,CDK,GSK-3,Mixed Lineage Kinase,PI3K,RIP kinase,ROS,Wnt/beta-catenin","Apoptosis","Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.",384.51,"465-39-4",{"v":100,"d":"100.00"},260.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/resibufogenin.html","C24H32O4","free base","Bufogenin, Recibufogenin","CC12CCC(O)CC1CCC3C2CCC4(C)C(CC5OC345)C6=COC(=O)C=C6",3.113,3,1,1]
["S3244","H3B-120","g2","L3000-43","in 10mM DMSO","CPSase","Metabolism","H3B-120 is a competitive, selective and allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits anti-tumor activity.",372.48,"2194903-42-7",{"v":74,"d":"74.00"},198.67,"<1","N/A","http://www.selleckchem.com/products/h3b-120.html","C19H24N4O2S","free base","N/A","CN(CC1=CC=CC=C1)C(=O)N2CCC(CC2)C(=O)NC3=NC(=CS3)C",1.901,3,1,4]
["S3245","Nodakenetin","h2","L3000-43","in 10mM DMSO","AChR,Aldose Reductase,Apoptosis related,BACE,BChE,Bcl-2,Carbohydrate Metabolism,phosphatase","Metabolism","Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.",246.26,"495-32-9",{"v":100,"d":"100.00"},406.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/nodakenetin.html","C14H14O4","free base","NANI","CC(C)(O)C1CC2=C(O1)C=C3OC(=O)C=CC3=C2",2.029,3,0,1]
["S3246","Picfeltarraenin IB","a3","L3000-43","in 10mM DMSO","AChR","Neuronal Signaling","Picfeltarraenin IB, a cucurbitacin glycoside isolated from Picriafel-terrae, is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.",792.95,"97230-46-1",{"v":100,"d":"100.00"},126.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/picfeltarraenin-ib.html","C42H64O14","free base","N/A","CC(C)C1=CC(=O)C(CO1)C2C(O)CC3(C)C4CC=C5C(CCC(OC6OC(CO)C(O)C(O)C6OC7OC(C)C(O)C(O)C7O)C5(C)C)C4(C)C(=O)CC23C",1.051,7,7,7]
["S3271","Caudatin","b3","L3000-43","in 10mM DMSO","Apoptosis related","Apoptosis","Caudatin (Cauldatin), one species of C‑21 steroidal from Cynanchum auriculatum (C. auriculatum), effectively inhibits human glioma growth in vitro and in vivo through triggering cell cycle arrest and apoptosis.",490.63,"38395-02-7",{"v":100,"d":"100.00"},203.82,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/caudatin.html","C28H42O7","free base","Cauldatin","CC(C)/C(C)=C/C(=O)OC1CC2C3(C)CCC(O)CC3=CCC2(O)C4(O)CCC(O)(C(C)=O)C14C",{"v":2.46,"d":"2.460"},3,1,5]
["S3273","Hypericin","c3","L3000-43","in 10mM DMSO","Hydroxylase,MAO,P450 (e.g. CYP17),PKC,Reverse Transcriptase,Telomerase","Metabolism","Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).",504.44,"548-04-9",{"v":100,"d":"100.00"},198.24,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hypericin.html","C30H16O8","free base","Hyp, HY","CC1=C2C3=C(C)C=C(O)C4=C3C5=C6C2=C(C(=C1)O)C(=O)C7=C6C(=C(O)C=C7O)C8=C(O)C=C(O)C(=C58)C4=O",{"v":5.04,"d":"5.040"},2,6,0]
["S3279","Polyphyllin B (Formosanin C)","d3","L3000-43","in 10mM DMSO","Anti-infection","Immunology & Inflammation","Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.",1015.18,"50773-42-7",{"v":100,"d":"100.00"},{"v":98.5,"d":"98.50"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/polyphyllin-b-formosanin-c-.html","C51H82O20","free base","FC","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(C)C(OC9OC(C)C(O)C(O)C9O)C(O)C8O)C(O)C7OC%10OC(C)C(O)C(O)C%10O",{"v":0.31,"d":"0.310"},10,10,9]
["S3289","Daphnoretin","e3","L3000-43","in 10mM DMSO","Akt,Apoptosis related,PKC","TGF-beta/Smad","Daphnoretin (Dephnoretin, Thymelol), a biologically active compound isolated from Wikstroemia indica C.A. Mey., is a protein kinase C (PKC) activator. Daphnoretin inhibits the proliferation, invasion, and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.",352.29,"2034-69-7",{"v":100,"d":"100.00"},283.86,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/daphnoretin.html","C19H12O7","free base","Dephnoretin, Thymelol","COC1=C(O)C=C2OC(=O)C(=CC2=C1)OC3=CC4=C(C=CC(=O)O4)C=C3",2.975,6,1,3]
["S3292","Falcarindiol","f3","L3000-43","in 10mM DMSO","ERK,Interleukins,JNK,NOS,STAT,TNF-alpha","Immunology & Inflammation","Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.",260.37,"225110-25-8",{"v":52,"d":"52.00"},199.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/falcarindiol.html","C17H24O2","free base","FAD, (3R,8S)-Falcarindiol, FaDOH","CCCCCCC\\C=C/C(O)C#CC#CC(O)C=C",4.713,0,2,11]
["S3296","Hispidulin","g3","L3000-43","in 10mM DMSO","Akt,AMPK,Apoptosis related,Mitochondrial Metabolism,PI3K,Pim","JAK/STAT","Hispidulin (Dinatin), an active natrual ingredient in a number of traditional Chinese medicinal herbs, exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71 μM. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.",300.26,"1447-88-7",{"v":100,"d":"100.00"},333.04,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hispidulin.html","C16H12O6","free base","Dinatin","COC1=C(O)C=C2OC(=CC(=O)C2=C1O)C3=CC=C(O)C=C3",2.394,3,3,2]
["S3300","Desoxyrhaponticin","h3","L3000-43","in 10mM DMSO","Apoptosis related,Carbohydrate Metabolism,Fatty Acid Synthase","Metabolism","Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.",404.41,"30197-14-9",{"v":100,"d":"100.00"},247.27,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/desoxyrhaponticin.html","C21H24O8","free base","DC, DES","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)OC3OC(CO)C(O)C(O)C3O",1.386,3,5,6]
["S6570","TPI-1","a4","L3000-43","in 10mM DMSO","phosphatase","Metabolism","TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent inhibitor of SHP-1 with IC50 of 40 nM for recombinant SHP-1. TPI-1 exhibits anticancer activity.",253.08,"79756-69-7",{"v":51,"d":"51.00"},201.52,"<1","N/A","http://www.selleckchem.com/products/tpi-1.html","C12H6Cl2O2","free base","Tyrosine Phosphatase Inhibitor 1","ClC1=CC(=C(Cl)C=C1)C2=CC(=O)C=CC2=O",3.495,2,0,1]
["S6630","Dimethylcurcumin (ASC-J9)","b4","L3000-43","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.",396.43,"52328-98-0",{"v":79,"d":"79.00"},199.28,"<1","N/A","http://www.selleckchem.com/products/dimethylcurcumin-asc-j9.html","C23H24O6","free base","Dimethyl curcumin, ASCJ 9, GO-Y025","COC1=CC=C(/C=C/C(O)=C/C(=O)/C=C/C2=CC=C(OC)C(=C2)OC)C=C1OC",4.024,5,1,9]
["S6762","Bozitinib (PLB-1001)","c4","L3000-43","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.",424.38,"1440964-89-5",{"v":85,"d":"85.00"},200.29,"<1","N/A","http://www.selleckchem.com/products/bozitinib.html","C20H15F3N8","free base","CBT-101, APL-101, CBI-3103","C[N]1C=C2C=C(C(=CC2=N1)F)C(F)(F)C3=NN=C4C=CC(=N[N]34)C5=C[N](N=C5)C6CC6",3.548,5,0,4]
["S6850","NE 52-QQ57","d4","L3000-43","in 10mM DMSO","cAMP,COX,GPR,Interleukins,NOS,PGES,TNF-alpha","GPCR & G Protein","NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).",416.52,"1401728-56-0",{"v":20,"d":"20.00"},48.02,"<1","N/A","http://www.selleckchem.com/products/ne-52-qq57.html","C24H28N6O","free base","N/A","CCC1=N[N]2C(=CC(=NC2=C1CC3=CC=C(C=C3)C4=NN=C(O4)C5CCNCC5)C)C",3.242,5,1,5]
["S6851","RA-190","e4","L3000-43","in 10mM DMSO","Autophagy,p53,Proteasome","Ubiquitin","RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.",596.76,"1617495-03-0",{"v":100,"d":"100.00"},167.57,"<1","N/A","http://www.selleckchem.com/products/ra-190.html","C28H23Cl5N2O2","free base","N/A","Cl.NC(CC1=CC=CC=C1)C(=O)N2CC(=C/C3=CC(=C(Cl)C=C3)Cl)/C(=O)C(/C2)=C\\C4=CC(=C(Cl)C=C4)Cl",7.285,2,1,5]
["S6852","Gossypol","f4","L3000-43","in 10mM DMSO","Apoptosis related,Bcl-2,Dehydrogenase","Apoptosis","Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.",518.55,"303-45-7",{"v":100,"d":"100.00"},192.85,"<1","N/A","http://www.selleckchem.com/products/gossypol.html","C30H30O8","free base","BL 193","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C)O",6.592,2,6,5]
["S6853","ONC206","g4","L3000-43","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","ONC206 is a selective antagonist of  DRD2/3/4 with broad-spectrum anti-tumor activity.",408.44,"1638178-87-6",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://www.selleckchem.com/products/onc206.html","C23H22F2N4O","free base","N/A","FC1=CC(=C(CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25)C=C1)F",3.137,2,0,4]
["S6870","Ningetinib","h4","L3000-43","in 10mM DMSO","Axl,c-Met,VEGFR","Protein Tyrosine Kinase","Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.",556.58,"1394820-69-9",{"v":20,"d":"20.00"},35.93,"<1","N/A","http://www.selleckchem.com/products/ningetinib.html","C31H29FN4O5","free base","CT-053, DE-120, CT053PTSA","CN1N(C(=O)C(=C1C)C(=O)NC2=CC(=C(OC3=C4C=CC(=CC4=NC=C3)OCC(C)(C)O)C=C2)F)C5=CC=CC=C5",3.942,5,1,8]
["S6877","EOAI3402143","a5","L3000-43","in 10mM DMSO","Apoptosis related,DUB","Ubiquitin","EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.",503.42,"1699750-95-2",{"v":100,"d":"100.00"},198.64,"<1","N/A","http://www.selleckchem.com/products/eoai3402143.html","C25H28Cl2N4O3","free base","N/A","CCCC(NC(=O)/C(=C/C1=C(Cl)C=CC(=N1)Cl)C#N)C2=CC=C(OCCN3CCOCC3)C=C2",4.911,4,1,10]
["S6880","SRT-1460","b5","L3000-43","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.",{"v":507.6,"d":"507.60"},"925432-73-1",{"v":20,"d":"20.00"},{"v":39.4,"d":"39.40"},"<1","N/A","http://www.selleckchem.com/products/srt-1460.html","C26H29N5O4S","free base","N/A","COC1=C(OC)C(=CC(=C1)C(=O)NC2=CC=CC=C2C3=C[N]4C(=CSC4=N3)CN5CCNCC5)OC",2.694,5,2,8]
["S6882","HI-TOPK-032","c5","L3000-43","in 10mM DMSO","Apoptosis related,Caspase,ERK,p53,PARP,TOPK","MAPK","HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.",{"v":369.4,"d":"369.40"},"487020-03-1",{"v":4,"d":"4.00"},10.83,"<1","N/A","http://www.selleckchem.com/products/hi-topk-032.html","C20H11N5OS","free base","N/A","O=C(NC1=CC2=C(C#N)C3=C(N=C4C=CC=CC4=N3)[N]2C=C1)C5=CC=CS5",3.567,3,1,2]
["S6905","MCP110","d5","L3000-43","in 10mM DMSO","Raf,Ras","MAPK","MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.",508.65,"521310-51-0",{"v":100,"d":"100.00"},{"v":196.6,"d":"196.60"},"<1","N/A","http://www.selleckchem.com/products/mcp110.html","C33H36N2O3","free base","N/A","COC1=CC(=CC=C1OCC2=CC=CC=C2)CN(CCC3=NC=CC=C3)C(=O)CCCCC4=CC=CC=C4",6.677,4,0,14]
["S7773","CDKI-73","e5","L3000-43","in 10mM DMSO","CDK","Cell Cycle","CDKI-73 (LS-007) is a potent CDK inhibitor in vitro with IC50 of 8.17 nM, 3.27 nM, 8.18 nM, and 5.78 nM for CDK1, CDK2, CDK4, and CDK9, respectively. CDKI-73 induces apoptosis in cancer cells. CDKI-73 is an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia.",394.45,"1421693-22-2",{"v":79,"d":"79.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/cdki-73.html","C15H15FN6O2S2","free base","N/A","CNC1=NC(=C(S1)C2=C(F)C=NC(=N2)NC3=CC(=CC=C3)[S](N)(=O)=O)C",2.359,5,3,5]
["S7803","GSK484 HCl","f5","L3000-43","in 10mM DMSO","PAD","Epigenetics","GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 50 nM in the absence of Calcium.",510.03,"1652591-81-5",{"v":100,"d":"100.00"},196.07,{"v":8,"d":"8.00"},15.69,"http://www.selleckchem.com/products/gsk484-hcl.html","C27H32ClN5O3","hydrochloride","GSK484 hydrochloride","Cl.COC1=CC(=CC2=C1[N](C)C(=N2)C3=CC4=C(C=CC=C4)[N]3CC5CC5)C(=O)N6CCC(O)C(N)C6",3.437,3,2,5]
["S8543","ARN-3236","g5","L3000-43","in 10mM DMSO","Apoptosis related,SIK","Immunology & Inflammation","ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.",336.41,"1613710-01-2",{"v":67,"d":"67.00"},199.16,"<1","N/A","http://www.selleckchem.com/products/arn-3236.html","C19H16N2O2S","free base","N/A","COC1=CC(=C(C=C1)C2=C[NH]C3=NC=CC(=C23)C4=CSC=C4)OC",3.837,3,1,4]
["S8574","BI 894999","h5","L3000-43","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BI 894999 is a potent and selective BET inhibitor with IC50 of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI 894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1.",429.51,"1660117-38-3",{"v":86,"d":"86.00"},200.23,"<1","N/A","http://www.selleckchem.com/products/bi894999.html","C25H27N5O2","free base","N/A","CC([N]1C2=CC(=NC=C2N=C1C3=NN(C)C(=O)C(=C3)C)C4CCOCC4)C5=CC=CC=C5",3.677,5,0,4]
["S8590","GSK 2837808A","a6","L3000-43","in 10mM DMSO","Dehydrogenase,LDH","Metabolism","GSK2837808A is a selective LDHA (lactate dehydrogenase A) inhibitor with IC50 of 2.6 nM and 43 nM for hLDHA and hLDHB, respectively.",649.62,"1445879-21-9",{"v":100,"d":"100.00"},153.94,"<1","N/A","http://www.selleckchem.com/products/gsk-2837808A.html","C31H25F2N5O7S","free base","N/A","COC1=NC=C(C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(O)=O)OC5=CC(=CC(=C5)F)F)[S](=O)(=O)NC6CC6)C(=N1)OC",5.335,9,2,11]
["S8730","BAY 1251152","b6","L3000-43","in 10mM DMSO","CDK","Cell Cycle","BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.",404.43,"1610358-56-9",{"v":81,"d":"81.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/bay1251152.html","C19H18F2N4O2S","free base","(+)-BAY-1251152","COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)C[S](C)(=N)=O",4.677,4,1,6]
["S8783","JSH-150","c6","L3000-43","in 10mM DMSO","CDK","Cell Cycle","JSH-150 is a highly selective and potent inhibitor of CDK9 with IC50 of 1 nM.",505.08,"2247481-21-4",{"v":100,"d":"100.00"},197.99,{"v":100,"d":"100.00"},197.99,"http://www.selleckchem.com/products/jsh-150.html","C24H33ClN6O2S","free base","N/A","COCCNC1CCC(CC1)NC2=NC=C(Cl)C(=C2)C3=CSC(=N3)NCC4(CCOCC4)C#N",3.162,4,3,10]
["S8824","EMD638683","d6","L3000-43","in 10mM DMSO","SGK","Metabolism","EMD638683 is a highly selective inhibitor of serum- and glucocorticoid-inducible kinase 1 (SGK1) with IC50 of 3 μM. EMD638683 exhibits antihypertensive potency and anti-tumor activity.",364.34,"1181770-72-8",{"v":73,"d":"73.00"},200.36,"<1","N/A","http://www.selleckchem.com/products/emd638683.html","C18H18F2N2O4","free base","N/A","CCC1=C(C)C(=CC=C1C(=O)NNC(=O)C(O)C2=CC(=CC(=C2)F)F)O",2.851,2,4,5]
["S8845","GSK3145095","e6","L3000-43","in 10mM DMSO","RIP kinase","Apoptosis","GSK3145095 is a potent and orally active RIP1 kinase inhibitor with IC50 of 6.3 nM with potential antineoplastic and immunomodulatory activities.",397.38,"1622849-43-7",{"v":79,"d":"79.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://www.selleckchem.com/products/gsk3145095.html","C20H17F2N5O2","free base","N/A","FC1=CC2=C(NC(=O)C(CC2)NC(=O)C3=N[NH]C(=N3)CC4=CC=CC=C4)C(=C1)F",2.573,4,3,4]
["S8850","JH-RE-06","f6","L3000-43","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).",468.72,"1361227-90-8",{"v":12,"d":"12.00"},{"v":25.6,"d":"25.60"},"<1","N/A","http://www.selleckchem.com/products/jh-re-06.html","C20H16Cl3N3O4","free base","N/A","CC(C)CC(=O)C1=C(NC2=CC=C(Cl)C=C2Cl)NC3=C(Cl)C=CC(=C3C1=O)[N+]([O-])=O",6.232,2,2,6]
["S8905","MYCi361","g6","L3000-43","in 10mM DMSO","Myc","Cell Cycle","MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.",594.86,"2289690-31-7",{"v":100,"d":"100.00"},168.11,"<1","N/A","http://www.selleckchem.com/products/myci361.html","C26H16ClF9N2O2","free base","NUCC-0196361","C[N]1N=C(C=C1C2=C(O)C(=C(OCC3=CC=C(Cl)C=C3)C=C2)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C(F)(F)F",9.052,2,1,8]
["S8906","MYCi975","h6","L3000-43","in 10mM DMSO","Myc","Cell Cycle","MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.",{"v":561.3,"d":"561.30"},"2289691-01-4",{"v":100,"d":"100.00"},178.16,"<1","N/A","http://www.selleckchem.com/products/myci975.html","C25H16Cl2F6N2O2","free base","NUCC-0200975","C[N]1N=C(C=C1C2=C(O)C(=C(OCC3=CC=C(Cl)C=C3)C=C2)C4=CC(=C(Cl)C=C4)C(F)(F)F)C(F)(F)F",8.775,2,1,7]
["S8916","BI-3406","a7","L3000-43","in 10mM DMSO","Ras","Cell Cycle","BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhibits anti-tumor activities.",462.46,"2230836-55-0",{"v":92,"d":"92.00"},198.94,"<1","N/A","http://www.selleckchem.com/products/bi-3406.html","C23H25F3N4O3","free base","N/A","COC1=C(OC2CCOC2)C=C3C(=NC(=NC3=C1)C)NC(C)C4=CC(=CC(=C4)N)C(F)(F)F",3.594,5,2,7]
["S8918","MS1943","b7","L3000-43","in 10mM DMSO","Histone Methyltransferase","Epigenetics","MS1943 is an orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity.",718.93,"2225938-17-8",{"v":100,"d":"100.00"},{"v":139.1,"d":"139.10"},"<1","N/A","http://www.selleckchem.com/products/ms1943.html","C42H54N8O3","free base","N/A","CC(C)[N]1N=CC2=C1C=C(C=C2C(=O)NCC3=C(C)C=C(C)NC3=O)C4=CN=C(C=C4)N5CCN(CCNC(=O)CC67CC8CC(CC(C8)C6)C7)CC5",4.773,5,3,11]
["S8929","GCN2iB","c7","L3000-43","in 10mM DMSO","Serine/threonin kinase","Metabolism","GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.",451.83,"2183470-12-2",{"v":15,"d":"15.00"},{"v":33.2,"d":"33.20"},"<1","N/A","http://www.selleckchem.com/products/gcn2ib.html","C18H12ClF2N5O3S","free base","N/A","COC1=NC=C(Cl)C=C1[S](=O)(=O)NC2=C(F)C(=C(F)C=C2)C#CC3=CN=C(N)N=C3",2.869,6,2,6]
["S8965","BO-264","d7","L3000-43","in 10mM DMSO","Apoptosis related,FGFR,TACC3","Cytoskeletal Signaling","BO-264 is a potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3) with IC50 of 188 nM and Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces SAC-dependent mitotic arrest, apoptosis and DNA damage with antitumor activities.",353.38,"2408648-20-2",{"v":71,"d":"71.00"},200.92,"<1","N/A","http://www.selleckchem.com/products/bo-264.html","C18H19N5O3","free base","N/A","COC1=CC=C(C=C1)C2=NOC(=C2)NC3=NC(=NC=C3)N4CCOCC4",{"v":3.02,"d":"3.020"},6,1,5]
["S8975","Mezigdomide (CC-92480)","e7","L3000-43","in 10mM DMSO","E3 Ligase","Ubiquitin","Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.",567.61,"2259648-80-9",{"v":100,"d":"100.00"},176.18,"<1","N/A","http://www.selleckchem.com/products/cc-92480.html","C32H30FN5O4","free base","N/A","FC1=CC(=CC=C1N2CCN(CC2)CC3=CC=C(COC4=CC=CC5=C4CN(C6CCC(=O)NC6=O)C5=O)C=C3)C#N",3.586,4,1,7]
["S8992","RBN012759","f7","L3000-43","in 10mM DMSO","PARP","DNA Damage/DNA Repair","RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.",378.46,"2360851-29-0",{"v":76,"d":"76.00"},200.81,"<1","N/A","http://www.selleckchem.com/products/rbn012759.html","C19H23FN2O3S","free base","N/A","OC1CCC(CC1)SCC2=NC3=CC(=CC(=C3C(=O)N2)F)OCC4CC4",2.941,3,2,6]
["S9602","Elraglusib","g7","L3000-43","in 10mM DMSO","Apoptosis related,GSK-3","PI3K/Akt/mTOR","Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.",404.35,"1034895-42-5",{"v":81,"d":"81.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/9-ing-41.html","C22H13FN2O5","free base","9-ing-41","C[N]1C=C(C2=CC3=C(OCO3)C=C12)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(F)C=C6",3.339,5,1,2]
["S9604","IM156","h7","L3000-43","in 10mM DMSO","AMPK,Apoptosis related,OXPHOS","PI3K/Akt/mTOR","IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.",315.29,"1422365-93-2",{"v":63,"d":"63.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/im156.html","C13H16F3N5O","free base","HL156A","FC(F)(F)OC1=CC=C(NC(=N)NC(=N)N2CCCC2)C=C1",3.622,1,2,7]
["S9611","ABTL-0812","a8","L3000-43","in 10mM DMSO","Akt,Autophagy,mTOR,ROS","PI3K/Akt/mTOR","ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.",296.44,"57818-44-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/abtl-0812.html","C18H32O3","free base","α-Hydroxylinoleic acid","CCCCC\\C=C/C\\C=C/CCCCCCC(O)C(O)=O",5.629,1,1,14]
["S9621","Donafenib (Sorafenib D3)","b8","L3000-43","in 10mM DMSO","Raf,VEGFR","MAPK","Donafenib (Sorafenib D3, Bay 43-9006 D3, CM-4307) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively.",467.84,"1130115-44-4",{"v":94,"d":"94.00"},200.92,"<1","N/A","http://www.selleckchem.com/products/donafenib-sorafenib-d3.html","C21H13D3ClF3N4O3","free base","Bay 43-9006 D3, CM-4307","C(NC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)([2H])([2H])[2H]",4.175,4,3,7]
["S9634","Phenoxodiol (Haginin E)","c8","L3000-43","in 10mM DMSO","Apoptosis related,Caspase,IAP,Topoisomerase","Apoptosis","Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.",240.25,"81267-65-4",{"v":48,"d":"48.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/phenoxodiol.html","C15H12O3","free base","Idronoxil, Dehydroequol, NV 06, PXD","OC1=CC=C(C=C1)C2=CC3=CC=C(O)C=C3OC2",3.029,1,2,1]
["S9639","VX-803 (M4344)","d8","L3000-43","in 10mM DMSO","ATM/ATR,Chk","PI3K/Akt/mTOR","VX-803 (M4344, ATR inhibitor 2) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.",541.55,"1613191-99-3",{"v":15,"d":"15.00"},{"v":27.7,"d":"27.70"},"<1","N/A","http://www.selleckchem.com/products/vx803-m4344.html","C25H29F2N9O3","free base","ATR inhibitor 2","NC1=N[N]2C=C(F)C=NC2=C1C(=O)NC3=C(N4CCC(CC4)C(=O)N5CCN(CC5)C6COC6)C(=CN=C3)F",-0.338,6,2,5]
["S9648","NEO2734","e8","L3000-43","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.",435.44,"2081072-29-7",{"v":87,"d":"87.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/neo2734.html","C22H24F3N3O3","free base","EP31670","CN1C=C(C=C(C)C1=O)C2=CC=C3N=C(C4CCOCC4)[N](CCOC(F)(F)F)C3=C2",4.151,4,0,6]
["S9649","Acelarin (NUC-1031)","f8","L3000-43","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM.",580.47,"840506-29-8",{"v":100,"d":"100.00"},172.27,"<1","N/A","http://www.selleckchem.com/products/acelarin-nuc-1031.html","C25H27F2N4O8P","free base","CPF-31, MTL-007, GTPL7389","CC(N[P](=O)(OCC1OC(N2C=CC(=NC2=O)N)C(F)(F)C1O)OC3=CC=CC=C3)C(=O)OCC4=CC=CC=C4",{"v":1.69,"d":"1.690"},7,3,12]
["S9658","SP-96","g8","L3000-43","in 10mM DMSO","Aurora Kinase","Cell Cycle","SP-96 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).",453.47,"2682114-54-9",{"v":91,"d":"91.00"},200.67,"<1","N/A","http://www.selleckchem.com/products/sp-146.html","C25H20FN7O","free base","N/A","CC1N=CC(=N1)C2=CC=C3C(=NC=NC3=C2)NC4=CC=CC(=C4)NC(=O)NC5=CC(=CC=C5)F",4.413,5,3,5]
["S0056","(E/Z)-BCI","h8","L3000-43","in 10mM DMSO","Apoptosis related,phosphatase,ROS","Metabolism","(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.",317.42,"15982-84-0",{"v":63,"d":"63.00"},198.48,"<1","N/A","https://www.selleckchem.com/products/dual-specificity-protein-phosphatase-1-6-Inhibitor-bcl.html","C22H23NO","Free Base","BCI, NSC 150117","O=C1\\C(=C/C2=CC=CC=C2)C(NC3CCCCC3)C4=CC=CC=C14",{"v":4.84,"d":"4.840"},1,1,3]
["S0140","KS176","a9","L3000-43","in 10mM DMSO","BCRP","Transmembrane Transporters","KS176 (compound 9) is a potent and selective inhibitor of the breast cancer resistance protein (BCRP, ABCG2) multidrug transporter with IC50 of 1.39 μM and 0.59 μM in Hoechst 33342 assay and Pheo A assay, respectively.",{"v":405.4,"d":"405.40"},"1253452-78-6",{"v":81,"d":"81.00"},{"v":199.8,"d":"199.80"},"<1","N/A","https://www.selleckchem.com/products/ks176.html","C22H19N3O5","Free Base","N/A","OCCC1=CC=C(NC(=O)C2=CC=CC=C2NC(=O)C3=CC=C(C=C3)[N+]([O-])=O)C=C1",{"v":3.01,"d":"3.010"},2,3,7]
["S0148","HAMNO","b9","L3000-43","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","HAMNO (NSC-111847) is a potent and selective replication protein A (RPA) inhibitor with anti-tumor activity. HAMNO inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR.",263.29,"138736-73-9",{"v":53,"d":"53.00"},{"v":201.3,"d":"201.30"},"<1","N/A","https://www.selleckchem.com/products/nsc111847.html","C17H13NO2","Free Base","NSC-111847","OC1=CC=CC=C1N/C=C/2C(=O)C=CC3=CC=CC=C23",2.908,1,2,2]
["S0149","C-DIM5","c9","L3000-43","in 10mM DMSO","Apoptosis related,Nur77","Cell Cycle","C-DIM5 (DIM-C-pPhOCH3) is an agonist of Nur77 (Nerve growth factor-induced Bα (NGFI-Bα)/nuclear receptor 4A1 (NR4A1)) which is an orphan nuclear receptor. C-DIM5 (DIM-C-pPhOCH3) decreases survival and induces apoptosis in RKO colon cancer cells.",352.43,"33985-68-1",{"v":70,"d":"70.00"},198.62,"<1","N/A","https://www.selleckchem.com/products/c-dim5.html","C24H20N2O","Free Base","DIM-C-pPhOCH3","COC1=CC=C(C=C1)C(C2=C[NH]C3=CC=CC=C23)C4=C[NH]C5=CC=CC=C45",5.659,1,2,4]
["S0267","TRi-1","d9","L3000-43","in 10mM DMSO","Thioredoxin Reductase","Metabolism","TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. TRi-1 exhibits anti-cancer activity while having little mitochondrial toxicity.",328.73,"246020-68-8",{"v":28,"d":"28.00"},85.18,"<1","N/A","https://www.selleckchem.com/products/tri-1.html","C12H9ClN2O5S","Free Base","HUN20688, TXNRD1 inhibitor 1","COC1=NC(=C(C=C1)[N+]([O-])=O)[S](=O)(=O)C2=CC=C(Cl)C=C2",3.402,4,0,4]
["S0283","COH-29","e9","L3000-43","in 10mM DMSO","RNR","DNA Damage/DNA Repair","COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.",420.44,"1190932-38-7",{"v":40,"d":"40.00"},95.14,{"v":60,"d":"60.00"},142.71,"https://www.selleckchem.com/products/coh-29.html","C22H16N2O5S","Free Base","RNR Inhibitor COH29","OC1=C(O)C=C(C=C1)C(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC(=C(O)C=C4)O",{"v":4.4,"d":"4.400"},2,5,4]
["S0323","Antineoplaston A10","f9","L3000-43","in 10mM DMSO","Ras","Apoptosis","Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.",246.26,"91531-30-5",{"v":49,"d":"49.00"},198.98,"<1","N/A","https://www.selleckchem.com/products/antineoplaston-a10.html","C13H14N2O3","Free Base","N/A","O=C1CCC(NC(=O)CC2=CC=CC=C2)C(=O)N1",0.307,3,2,3]
["S0344","Y06036","g9","L3000-43","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Y06036 (Compound 6i) is a potent and selective inhibitor of BET with antitumor activity. Y06036 binds to the BRD4(1) bromodomain with Kd of 82 nM.",427.27,"1832671-96-1",{"v":85,"d":"85.00"},198.94,"<1","N/A","https://www.selleckchem.com/products/y06036.html","C16H15BrN2O5S","Free Base","N/A","COC1=C(N[S](=O)(=O)C2=C(OC)C=CC(=C2)Br)C=C3C(=NOC3=C1)C",2.969,6,1,5]
["S0354","Alsterpaullone","h9","L3000-43","in 10mM DMSO","Apoptosis related,Caspase,CDK,GSK-3","Cell Cycle","Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.",293.28,"237430-03-4",{"v":25,"d":"25.00"},85.24,"<1","N/A","https://www.selleckchem.com/products/alsterpaullone.html","C16H11N3O3","Free Base","Alp, 9-Nitropaullone, NSC 705701","[O-][N+](=O)C1=CC2=C([NH]C3=C2CC(=O)NC4=CC=CC=C34)C=C1",2.817,1,2,1]
["S0431","ML281","a10","L3000-43","in 10mM DMSO","Serine/threonin kinase","Apoptosis","ML281 is a potent and selective inhibitor of Serine/threonine kinase 33 (STK33) with IC50 of 0.014 μM. ML281 is selectively toxic to KRAS-dependent cancer cell lines.",389.47,"1404437-62-2",{"v":78,"d":"78.00"},200.27,"<1","N/A","https://www.selleckchem.com/products/ml281.html","C22H19N3O2S","Free Base","N/A","CC(C)C1=CC(=C(NC(=O)C2=CC=CS2)C=C1)C3=NC4=CC=CC=C4NC3=O",4.439,3,2,4]
["S0765","MAZ51","b10","L3000-43","in 10mM DMSO","Akt,Apoptosis related,GSK-3,Rho,VEGFR","Protein Tyrosine Kinase","MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.",314.38,"163655-37-6",{"v":15,"d":"15.00"},47.71,"<1","N/A","https://www.selleckchem.com/products/maz51.html","C21H18N2O","Free Base","N/A","CN(C)C1=CC=C(\\C=C/2C(=O)NC3=CC=CC=C23)C4=CC=CC=C14",3.801,1,1,2]
["S0780","Oncrasin-1","c10","L3000-43","in 10mM DMSO","DNA/RNA Synthesis,PKC","Cell Cycle","Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.",269.73,"75629-57-1",{"v":54,"d":"54.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/oncrasin-1.html","C16H12ClNO","Free Base","N/A","ClC1=CC=C(C[N]2C=C(C=O)C3=C2C=CC=C3)C=C1",4.336,1,0,3]
["S0884","RA-9","d10","L3000-43","in 10mM DMSO","Apoptosis related,DUB","Ubiquitin","RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.",365.34,"919091-63-7",{"v":8,"d":"8.00"},{"v":21.9,"d":"21.90"},"<1","N/A","https://www.selleckchem.com/products/ra-9.html","C19H15N3O5","Free Base","N/A","[O-][N+](=O)C1=CC=C(C=C1)\\C=C2/CNC\\C(=C/C3=CC=C(C=C3)[N+]([O-])=O)C2=O",{"v":3.16,"d":"3.160"},1,1,4]
["S0978","TBOPP","e10","L3000-43","in 10mM DMSO","DOCK","GPCR & G Protein","TBOPP is a selective inhibitor of dedicator of cytokinesis (DOCK1, Dock180) that inhibits DOCK1-mediated Rac activation with IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with Kd of 7.1 μM. TBOPP exhibits anti-tumor activity.",490.49,"1996629-79-8",{"v":98,"d":"98.00"},{"v":199.8,"d":"199.80"},"<1","N/A","https://www.selleckchem.com/products/tbopp.html","C24H21F3N2O4S","Free Base","N/A","FC(F)(F)C1=CC=CC(=C1)C2=CC=C(C=C2)C(=O)CN3C=C(C=CC3=O)[S](=O)(=O)N4CCCC4",2.881,4,0,7]
["S0989","ML-180","f10","L3000-43","in 10mM DMSO","Others","Others","ML-180 (SR1848) is a potent inverse agonist of orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) with IC50 of 3.7 μM. ML-180 has the potential for LRH-1-dependent cancers.",388.89,"863588-32-3",{"v":10,"d":"10.00"},25.71,"<1","N/A","https://www.selleckchem.com/products/ml-180.html","C20H25ClN4O2","Free Base","SR1848","ClC1=CC=CC(=C1)N2CCN(CC2)C3=CC(=O)N(C4CCCCC4)C(=O)N3",4.094,2,1,3]
["S1198","Irinotecan (CPT-11)","g10","L3000-43","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11, (+)-Irinotecan) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.",586.68,"97682-44-5",{"v":51,"d":"51.00"},86.93,"<1","N/A","https://www.selleckchem.com/products/Irinotecan-cpt-11.html","C33H38N4O6","Free Base","(+)-Irinotecan,CPT-11","CCC1=C2C=C(OC(=O)N3CCC(CC3)N4CCCCC4)C=CC2=NC5=C1CN6C(=O)C7=C(C=C56)C(O)(CC)C(=O)OC7",3.686,6,0,5]
["S1273","Amarogentin","h10","L3000-43","in 10mM DMSO","Akt,AMPK,Apoptosis related,PI3K,Taste Receptor,TNF-alpha","GPCR & G Protein","Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.",586.54,"21018-84-8",{"v":100,"d":"100.00"},170.49,"<1","N/A","https://www.selleckchem.com/products/amarogentin.html","C29H30O13","Free Base","AG","OCC1OC(OC2OC=C3C(CCOC3=O)C2C=C)C(OC(=O)C4=C(O)C=C(O)C=C4C5=CC=CC(=C5)O)C(O)C1O",1.428,7,6,8]
["S2937","SYP-5","a11","L3000-43","in 10mM DMSO","HIF","Angiogenesis","SYP-5 is an inhibitor of Hypoxia-inducible factor-1 (HIF-1) that suppresses tumor cell migration and invasion, as well as tumor angiogenesis.",312.38,"1384268-04-5",{"v":62,"d":"62.00"},198.48,"<1","N/A","https://www.selleckchem.com/products/syp-5.html","C18H16O3S","Free Base","N/A","CC1(C)OC2=C(C=C1)C(=C(C=C2)C(=O)\\C=C\\C3=CC=CS3)O",{"v":4.2,"d":"4.200"},2,1,3]
["S2942","EB-3D","b11","L3000-43","in 10mM DMSO","AMPK,Apoptosis related,Choline kinase","Cell Cycle","EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.",644.44,"1839150-63-8",{"v":50,"d":"50.00"},77.59,{"v":25,"d":"25.00"},38.79,"https://www.selleckchem.com/products/eb-3d.html","C30H36Br2N4O2","Free Base","N/A","[Br-].[Br-].CN(C)C1=CC=[N+](CC2=CC=C(OCCOC3=CC=C(C[N+]4=CC=C(C=C4)N(C)C)C=C3)C=C2)C=C1",{"v":1.31,"d":"1.310"},2,0,11]
["S2962","NP-G2-044","c11","L3000-43","in 10mM DMSO","Fascin","Stem Cells & Wnt","NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.",399.37,"1807454-59-6",{"v":80,"d":"80.00"},200.32,"<1","N/A","https://www.selleckchem.com/products/np-g2-044.html","C21H16F3N3O2","Free Base","N/A","CC1=C(C=CO1)C(=O)NC2=N[N](CC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C24",4.778,3,1,5]
["S2986","9-Methoxycanthin-6-one","d11","L3000-43","in 10mM DMSO","Others","Others","9-Methoxycanthin-6-one is present in intact plant parts and in callus tissues of different explants with anti-tumour activity.",250.25,"74991-91-6",{"v":10,"d":"10.00"},39.96,"<1","N/A","https://www.selleckchem.com/products/9-methoxycanthin-6-one.html","C15H10N2O2","Free Base","N/A","COC1=CC2=C(C=C1)C3=C4[N]2C(=O)C=CC4=NC=C3",2.876,3,0,1]
["S3095","Itaconic acid","e11","L3000-43","in 10mM DMSO","Others","Others","Itaconic acid, a macrophage-specific (Mϕ-specific) metabolite, mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid is also a precursor of polymers, chemicals, and fuels that can be synthesized by many fungi.",{"v":130.1,"d":"130.10"},"97-65-4",{"v":26,"d":"26.00"},199.85,{"v":5,"d":"5.00"},38.43,"https://www.selleckchem.com/products/itaconic-acid.html","C5H6O4","Free Base","N/A","OC(=O)CC(=C)C(O)=O",0.117,2,0,3]
["S3141","Maleimide","f11","L3000-43","in 10mM DMSO","ADC Linker,Dyes","Others","Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.",97.07,"541-59-3",{"v":19,"d":"19.00"},195.74,{"v":19,"d":"19.00"},195.74,"https://www.selleckchem.com/products/maleimide.html","C4H3NO2","Free Base","N/A","O=C1NC(=O)C=C1",-0.395,2,1,0]
["S3313","Nudifloric Acid","g11","L3000-43","in 10mM DMSO","Others","Others","Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid), isolated from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities.",153.14,"3719-45-7",{"v":30,"d":"30.00"},{"v":195.9,"d":"195.90"},"<1","N/A","https://www.selleckchem.com/products/nudifloric-acid.html","C7H7NO3","Free Base","1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid","CN1C=C(C=CC1=O)C(O)=O",-0.528,2,0,1]
["S3337","L-Histidinol dihydrochloride","h11","L3000-43","in 10mM DMSO","Others","Metabolism","L-Histidinol dihydrochloride, a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.",214.09,"1596-64-1",{"v":43,"d":"43.00"},200.85,{"v":43,"d":"43.00"},200.85,"https://www.selleckchem.com/products/l-histidinol-dihydrochloride.html","C6H13Cl2N3O","Dihydrochloride","N/A","Cl.Cl.NC(CO)CC1=CN=C[NH]1",-0.598,1,3,3]
["S5248","Apatinib","a2","L3000-44","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,c-RET,Src,VEGFR","Protein Tyrosine Kinase","Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis.",397.47,"811803-05-1",{"v":79,"d":"79.00"},198.76,"<1","N/A","https://www.selleckchem.com/products/apatinib.html","C24H23N5O","Free Base","Rivoceranib, YN968D1","O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=C(NCC4=CC=NC=C4)N=CC=C3",3.578,3,2,6]
["S6901","MSAB","b2","L3000-44","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.",305.35,"173436-66-3",{"v":61,"d":"61.00"},199.77,"<1","N/A","https://www.selleckchem.com/products/msab.html","C15H15NO4S","Free Base","N/A","COC(=O)C1=CC=CC(=C1)N[S](=O)(=O)C2=CC=C(C)C=C2",2.659,4,1,5]
["S6934","AMG-9810","c2","L3000-44","in 10mM DMSO","TLR,TRP Channel","Transmembrane Transporters","AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.",337.41,"545395-94-6",{"v":67,"d":"67.00"},198.57,"<1","N/A","https://www.selleckchem.com/products/amg-9810.html","C21H23NO3","Free Base","N/A","CC(C)(C)C1=CC=C(/C=C/C(=O)NC2=CC=C3OCCOC3=C2)C=C1",4.268,3,1,4]
["S6948","Lanreotide","d2","L3000-44","in 10mM DMSO","GHSR","Endocrinology & Hormones","Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum), an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.",1096.32,"108736-35-2",{"v":100,"d":"100.00"},91.21,{"v":100,"d":"100.00"},91.21,"https://www.selleckchem.com/products/lanreotide.html","C54H69N11O10S2","Free Base","Laromustine, Angiopeptin, BIM 23014, BIM 23014C, BM 23014, Dermopeptin, Ipstyl, ITM-014, ITM-014T, Somatulina, Somatuline, Lanreotidum","CC(C)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(C(C)O)C(N)=O)NC(=O)C(N)CC5=CC6=CC=CC=C6C=C5",1.704,8,13,17]
["S6957","β-Elemene","e2","L3000-44","in 10mM DMSO","Apoptosis related,Autophagy","Apoptosis","β-Elemene ((-)-β-Elemene, Levo-β-elemene) is a sesquiterpene compound extracted from the herb Curcuma Rhizoma with antitumor activities. β-elemene can inhibit cell proliferation, arrest the cell cycle, and induce cell apoptosis or autophagy.",204.35,"515-13-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/b-elemene.html","C15H24","Free Base","(-)-β-Elemene, Levo-β-elemene","CC(=C)C1CCC(C)(C=C)C(C1)C(C)=C",4.788,0,0,3]
["S6958","Treosulfan","f2","L3000-44","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.",{"v":278.3,"d":"278.30"},"299-75-2",{"v":56,"d":"56.00"},201.22,{"v":56,"d":"56.00"},201.22,"https://www.selleckchem.com/products/treosulfan.html","C6H14O8S2","Free Base","NSC 39069, Treosulphan","C[S](=O)(=O)OCC(O)C(O)CO[S](C)(=O)=O",-1.953,2,2,7]
["S6962","TPEN","g2","L3000-44","in 10mM DMSO","Apoptosis related,NOS","Apoptosis","TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling. TPEN (TPEDA) may be a potential therapeutic strategy for APL (acute promyelocytic leukemia).",424.54,"16858-02-9",{"v":85,"d":"85.00"},200.22,"<1","N/A","https://www.selleckchem.com/products/tpen.html","C26H28N6","Free Base","TPEDA","C(CN(CC1=NC=CC=C1)CC2=NC=CC=C2)N(CC3=NC=CC=C3)CC4=NC=CC=C4",{"v":3.05,"d":"3.050"},4,0,11]
["S6963","APTO-253","h2","L3000-44","in 10mM DMSO","Apoptosis related,KLF,Myc,p21","Cell Cycle","APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Kr&uuml;ppel-like factor 4).",367.38,"916151-99-0",{"v":73,"d":"73.00"},{"v":198.7,"d":"198.70"},"<1","N/A","https://www.selleckchem.com/products/apto-253.html","C22H14FN5","Free Base","LOR-253, LT-253","CC1=C(C2=NC3=C([NH]2)C4=CC=CN=C4C5=C3C=CC=N5)C6=C([NH]1)C=CC(=C6)F",4.287,3,2,1]
["S8351","PT2399","a3","L3000-44","in 10mM DMSO","HIF","Angiogenesis","PT2399 is a potent and orally available antagonist of HIF-2 that selectively disrupts the heterodimerization of HIF-2α with HIF-1β.",419.32,"1672662-14-4",{"v":84,"d":"84.00"},200.32,"<1","N/A","https://www.selleckchem.com/products/pt2399.html","C17H10F5NO4S","Free Base","N/A","OC1C2=C(C=CC(=C2CC1(F)F)OC3=CC(=CC(=C3)F)C#N)[S](=O)(=O)C(F)F",3.554,3,1,4]
["S8919","LY-3381916","b3","L3000-44","in 10mM DMSO","IDO/TDO","Metabolism","LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.",396.45,"2166616-75-5",{"v":79,"d":"79.00"},199.27,"<1","N/A","https://www.selleckchem.com/products/ly-3381916.html","C23H25FN2O3","Free Base","IDO1-IN-5","CC(NC(=O)C1=CC=C(F)C=C1)C2=CC=C3N(CCC3=C2)C(=O)C4CCOCC4",2.962,3,1,4]
["S8957","Navoximod","c3","L3000-44","in 10mM DMSO","IDO/TDO","Metabolism","Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.",316.37,"1402837-78-8",{"v":63,"d":"63.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/navoximod.html","C18H21FN2O2","Free Base","GDC-0919, NLG-919","OC1CCC(CC1)C(O)CC2[N]3C=NC=C3C4=C2C(=CC=C4)F",2.224,1,2,3]
["S8993","Atamparib (RBN-2397)","d3","L3000-44","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Atamparib (RBN-2397) is a potent, selective and orally active NAD+ competitive inhibitor PARP7 with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment.",523.43,"2381037-82-5",{"v":100,"d":"100.00"},191.05,"<1","N/A","https://www.selleckchem.com/products/rbn-2397.html","C20H23F6N7O3","Free Base","N/A","CC(COCCC(=O)N1CCN(CC1)C2=NC=C(C=N2)C(F)(F)F)NC3=C(C(=O)NN=C3)C(F)(F)F",0.907,6,2,10]
["S9029","Prim-o-glucosylcimifugin","e3","L3000-44","in 10mM DMSO","COX,NOS","Immunology & Inflammation","Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.",468.45,"80681-45-4",{"v":94,"d":"94.00"},200.66,{"v":94,"d":"94.00"},200.66,"https://www.selleckchem.com/products/prim-o-glucosylcimifugin.html","C22H28O11","Free Base","Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside","COC1=C2CC(OC2=CC3=C1C(=O)C=C(COC4OC(CO)C(O)C(O)C4O)O3)C(C)(C)O",{"v":-0.62,"d":"-0.620"},6,4,6]
["S9037","Tenacissoside H","f3","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects.",794.97,"191729-45-0",{"v":100,"d":"100.00"},125.79,"<1","N/A","https://www.selleckchem.com/products/tenacissoside-h.html","C42H66O14","Free Base","N/A","CCC(C)C(=O)OC1C(OC(C)=O)C2(C)C(CCC23OC34CCC5CC(CCC5(C)C14)OC6CC(OC)C(OC7OC(C)C(O)C(OC)C7O)C(C)O6)C(C)=O",2.827,12,2,13]
["S9074","Buddlejasaponin IVb","g3","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.",943.12,"152580-79-5",{"v":100,"d":"100.00"},106.03,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/buddlejasaponin-ivb.html","C48H78O18","Free Base","Saikosaponin 1b","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC5=C6CC(C)(C)CCC6(CO)C(O)CC45C)C2(C)CO)C(OC7OC(CO)C(O)C(O)C7O)C(OC8OC(CO)C(O)C(O)C8O)C1O",-0.583,6,12,10]
["S9156","Chonglou Saponin VII","h3","L3000-44","in 10mM DMSO","GSK-3","Stem Cells & Wnt","Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.",1031.18,"68124-04-9",{"v":100,"d":"100.00"},96.98,"<1","N/A","https://www.selleckchem.com/products/chonglou-saponin-vii.html","C51H82O21","Free Base","Dioscinin, Polyphyllin-VII, Paris saponin-VII","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3(O)C2C)OC7OC(CO)C(OC8OC(C)C(OC9OC(C)C(O)C(O)C9O)C(O)C8O)C(O)C7OC%10OC(C)C(O)C(O)C%10O",-0.337,10,10,9]
["S9203","Notopterol","a4","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities.",{"v":354.4,"d":"354.40"},"88206-46-6",{"v":71,"d":"71.00"},200.34,"<1","N/A","https://www.selleckchem.com/products/notopterol.html","C21H22O5","Free Base","N/A","CC(C)=CC(O)CC(/C)=C/COC1=C2C=COC2=CC3=C1C=CC(=O)O3",4.377,4,1,6]
["S9208","Ginsenoside Rb3","b4","L3000-44","in 10mM DMSO","COX,NF-κB,NOS","NF-κB","Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL).",1079.27,"68406-26-8",{"v":100,"d":"100.00"},92.66,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/ginsenoside-rb3.html","C53H90O22","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-0.688,8,14,15]
["S9210","Ginsenoside Rk1","c4","L3000-44","in 10mM DMSO","Others","Others","Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity.",{"v":767,"d":"767.00"},"494753-69-4",{"v":100,"d":"100.00"},130.38,{"v":100,"d":"100.00"},130.38,"https://www.selleckchem.com/products/ginsenoside-rk1.html","C42H70O12","Free Base","N/A","CC(C)=CCCC(=C)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",3.315,4,8,10]
["S9237","Berberrubine","d4","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.",357.79,"15401-69-1",{"v":72,"d":"72.00"},201.24,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/berberrubine.html","C19H16ClNO4","Free Base","Beroline, 9-Berberoline","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1O)C=C5OCOC5=C4",1.063,3,1,1]
["S9247","Isoliensinine","e4","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"6817-41-0",{"v":100,"d":"100.00"},163.74,"<1","N/A","https://www.selleckchem.com/products/isoliensinine.html","C37H42N2O6","Free Base","N/A","COC1=CC=C(CC2N(C)CCC3=C2C=C(OC4=C(O)C=CC(=C4)CC5N(C)CCC6=C5C=C(O)C(=C6)OC)C(=C3)OC)C=C1",{"v":7.02,"d":"7.020"},4,2,9]
["S9262","Raddeanin A","f4","L3000-44","in 10mM DMSO","HDAC","Epigenetics","Raddeanin A (Raddeanin R3, NSC382873), a triterpenoid saponin from Anemone raddeana Regel, displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity.",{"v":897.1,"d":"897.10"},"89412-79-3",{"v":100,"d":"100.00"},111.47,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/raddeanin-a.html","C47H76O16","Free Base","Raddeanin R3, NSC382873","CC1OC(OC2C(O)C(O)C(CO)OC2OC3C(O)C(O)COC3OC4CCC5(C)C(CCC6(C)C5CC=C7C8CC(C)(C)CCC8(CCC67C)C(O)=O)C4(C)C)C(O)C(O)C1O",2.605,7,8,8]
["S9266","Ginsenoside Rc","g4","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.",1079.27,"11021-14-0",{"v":100,"d":"100.00"},92.66,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/ginsenoside-rc.html","C53H90O22","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-0.688,8,14,16]
["S9269","Epmedin C","h4","L3000-44","in 10mM DMSO","Others","Others","Epimedin C (Baohuoside VI), a flavonoid isolated from the herbs of Epimedium brevicornum Maxim, exhibits immunostimulatory and anticancer activities.",{"v":822.8,"d":"822.80"},"110642-44-9 (119760-73-5)",{"v":100,"d":"100.00"},121.54,{"v":100,"d":"100.00"},121.54,"https://www.selleckchem.com/products/epmedin-c.html","C39H50O19","Free Base","Baohuoside VI","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C(=O)C5=C(O2)C(=C(OC6OC(CO)C(O)C(O)C6O)C=C5O)CC=C(C)C",0.124,9,10,11]
["S9300","Methylprotodioscin","a5","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and\n\nanticancer activities.",1063.23,"54522-52-0",{"v":100,"d":"100.00"},94.05,{"v":100,"d":"100.00"},94.05,"https://www.selleckchem.com/products/methylprotodioscin.html","C52H86O22","Free Base","N/A","COC1(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C1C)OC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",-0.936,10,12,15]
["S9433","Tubeimoside II","b5","L3000-44","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects.",1335.43,"115810-12-3",{"v":100,"d":"100.00"},74.88,{"v":100,"d":"100.00"},74.88,"https://www.selleckchem.com/products/tubeimoside-ii.html","C63H98O30","Free Base","Tubeimoside B","CC1OC2OC3C(O)C(O)COC3OC(=O)C45CCC(C)(C)CC4C6=CCC7C8(C)CC(O)C(OC9OC(CO)C(O)C(O)C9OC%10OCC(OC(=O)CC(C)(O)CC(=O)OC1C(OC%11OCC(O)C(O)C%11O)C2O)C(O)C%10O)C(C)(CO)C8CCC7(C)C6(C)CC5O",-2.708,15,14,4]
["S9521","Pentostatin","c5","L3000-44","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.",268.27,"53910-25-1",{"v":54,"d":"54.00"},201.29,{"v":54,"d":"54.00"},201.29,"https://www.selleckchem.com/products/pentostatin.html","C11H16N4O4","Free Base","CI-825,Deoxycoformycin","OCC1OC(CC1O)[N]2C=NC3=C2NC=NCC3O",-1.965,3,4,2]
["S9636","DRB18","d5","L3000-44","in 10mM DMSO","GLUT","Metabolism","DRB18 is a pan-GLUT (glucose transporters) inhibitor that inhibits growth and proliferation in several different cancer types with IC50 high nM range.",382.88,"unknown",{"v":76,"d":"76.00"},{"v":198.5,"d":"198.50"},"<1","N/A","https://www.selleckchem.com/products/drb18.html","C22H23ClN2O2","Free Base","N/A","CC1=CC=C(CNC2=C(NCC3=CC(=C(C)C=C3)O)C=C(Cl)C=C2)C=C1O",5.767,0,4,6]
["S9645","CBR-5884","e5","L3000-44","in 10mM DMSO","Dehydrogenase","Metabolism","CBR-5884 is a selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and was selectively toxic to cancer cell lines with high serine biosynthetic activity.",336.39,"681159-27-3",{"v":67,"d":"67.00"},199.17,"<1","N/A","https://www.selleckchem.com/products/cbr-5884.html","C14H12N2O4S2","Free Base","N/A","CCOC(=O)C1=C(C)C(=C(NC(=O)C2=CC=CO2)S1)SC#N",3.252,4,1,6]
["S9677","NCGC00378430","f5","L3000-44","in 10mM DMSO","Others","Epigenetics","NCGC00378430 is an inhibitor of the SIX1/EYA2 complex that significantly suppresses breast cancer-associated metastasis in vivo without significantly altering primary tumor growth.",{"v":441.5,"d":"441.50"},"920650-00-6",{"v":88,"d":"88.00"},199.32,"<1","N/A","https://www.selleckchem.com/products/ncgc00378430.html","C22H23N3O5S","Free Base","N/A","COC1=C(C=C(NC(=O)C2=CC(=CC=C2)[N]3C=CC=C3)C=C1)[S](=O)(=O)N4CCOCC4",2.279,5,1,6]
["S9681","MSA-2","g5","L3000-44","in 10mM DMSO","STING","Immunology & Inflammation","MSA-2 is an orally available non-nucleotide human STING agonist with antitumor activity.",294.32,"129425-81-6",{"v":59,"d":"59.00"},200.46,"<1","N/A","https://www.selleckchem.com/products/msa-2.html","C14H14O5S","Free Base","N/A","COC1=C(OC)C=C2C=C(SC2=C1)C(=O)CCC(O)=O",2.535,4,0,6]
["S9689","FDI-6","h5","L3000-44","in 10mM DMSO","FOXM1","Cell Cycle","FDI-6 (NCGC00099374) is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) with IC50 of 22.5 μM.",437.43,"313380-27-7",{"v":87,"d":"87.00"},198.89,"<1","N/A","https://www.selleckchem.com/products/fdi-6.html","C19H11F4N3OS2","Free Base","NCGC00099374","NC1=C(SC2=NC(=CC(=C12)C(F)(F)F)C3=CC=CS3)C(=O)NC4=CC=C(F)C=C4",5.117,2,2,4]
["S9695","iHAP1","a6","L3000-44","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","iHAP1 is a well-established microtubule poison, blocks microtubule polymerization fully at 5 µM which is independent of deregulated transcription, causes marked sensitization when deleting Rod1 gene in HeLa cells.",367.85,"105925-39-1",{"v":20,"d":"20.00"},54.37,"<1","N/A","https://www.selleckchem.com/products/ihap1.html","C20H14ClNO2S","Free Base","N/A","COC1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4",5.333,2,0,2]
["S9698","Ezatiostat","b6","L3000-44","in 10mM DMSO","Apoptosis related,ERK,JNK,Transferase","Metabolism","Ezatiostat (TER199, TLK199, Telintra), a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1). Ezatiostat activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis.",643.67,"168682-53-9",{"v":100,"d":"100.00"},155.36,"<1","N/A","https://www.selleckchem.com/products/ezatiostat.html","C29H36F3N3O8S","Free Base","TER199, TLK199, Telintra","CCOC(=O)C(N)CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C(=O)OCC)C2=CC=CC=C2.OC(=O)C(F)(F)F",0.745,7,3,18]
["S9703","IACS-13909","c6","L3000-44","in 10mM DMSO","phosphatase","Metabolism","IACS-13909  is a specific and potent allosteric inhibitor of SHP2 (Src homology 2 domain-containing phosphatase) that suppresses signaling through the MAPK pathway.",377.27,"2160546-07-4",{"v":75,"d":"75.00"},{"v":198.8,"d":"198.80"},"<1","N/A","https://www.selleckchem.com/products/iacs-13909.html","C17H18Cl2N6","Free Base","BBP-398","CC1(N)CCN(CC1)C2=CN=C3C(=N2)[NH]N=C3C4=CC=CC(=C4Cl)Cl",3.125,3,2,2]
["S9712","Fluzoparib (SHR-3162)","d6","L3000-44","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity, with an IC50 of 1.46±0.72 nM for PARP1.",{"v":472.4,"d":"472.40"},"1358715-18-0",{"v":94,"d":"94.00"},198.98,"<1","N/A","https://www.selleckchem.com/products/fluzoparib.html","C22H16F4N6O2","Free Base","HS10160","FC1=CC=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1C(=O)N4CC[N]5N=C(N=C5C4)C(F)(F)F",2.757,5,1,4]
["S9718","TK216","e6","L3000-44","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.",376.23,"1903783-48-1",{"v":75,"d":"75.00"},199.35,"<1","N/A","https://www.selleckchem.com/products/tk216.html","C19H15Cl2NO3","Free Base","ONCT 216, SPH-8216","OC1(CC(=O)C2=CC=C(C=C2)C3CC3)C(=O)NC4=C(Cl)C=CC(=C14)Cl",3.785,2,1,4]
["S9719","CB-103","f6","L3000-44","in 10mM DMSO","Notch","Neuronal Signaling","CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.",242.32,"218457-67-1",{"v":48,"d":"48.00"},198.09,"<1","N/A","https://www.selleckchem.com/products/cb-103.html","C15H18N2O","Free Base","N/A","CC(C)(C)C1=CC=C(OC2=CC=C(N)C=N2)C=C1",3.432,2,1,3]
["S9785","Fatostatin","g6","L3000-44","in 10mM DMSO","Apoptosis related,Fatty Acid Synthase,SREBP","Metabolism","Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.",294.41,"125256-00-0",{"v":75,"d":"75.00"},254.75,"<1","N/A","https://www.selleckchem.com/products/fatostatin.html","C18H18N2S","Free Base","125B11","CCCC1=CC(=CC=N1)C2=NC(=CS2)C3=CC=C(C)C=C3",4.898,2,0,4]
["S0503","Estrogen receptor modulator 1","h6","L3000-44","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM) with pIC50 of 0.46. Estrogen receptor modulator 1 exhibits potential anti-tumor activity.",242.29,"63676-22-2",{"v":48,"d":"48.00"},198.11,"<1","N/A","http://www.selleckchem.com/products/estrogen-receptor-modulator-1.html","C14H10O2S","Free Base","N/A","OC1=CC=C(C=C1)C2=CC3=C(S2)C=C(O)C=C3",4.017,0,2,1]
["S0522","CM10","a7","L3000-44","in 10mM DMSO","Dehydrogenase","Metabolism","CM10 is a potent and selective inhibitor of aldehyde dehydrogenase 1A family (ALDH1A) with IC50 of 1700 nM, 740 nM and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively. CM10 exhibits anti-cancer activity.",321.42,"692269-09-3",{"v":64,"d":"64.00"},199.12,"<1","N/A","http://www.selleckchem.com/products/cm10.html","C20H23N3O","Free Base","N/A","CCC[N]1C(=NC2=CC=CC=C12)NCC3=CC=CC(=C3O)CC=C",5.123,1,2,7]
["S2968","CTPI-2","b7","L3000-44","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs).",356.74,"68003-38-3",{"v":71,"d":"71.00"},199.02,"<1","N/A","http://www.selleckchem.com/products/ctpi-2.html","C13H9ClN2O6S","Free Base","N/A","OC(=O)C1=CC=CC=C1N[S](=O)(=O)C2=CC(=C(Cl)C=C2)[N+]([O-])=O",2.506,3,1,5]
["S2995","4-Hydroxyphenylpyruvic acid","c7","L3000-44","in 10mM DMSO","COX","Immunology & Inflammation","4-Hydroxyphenylpyruvic acid (4-HPPA), an abundant colon metabolite of polyphenols, is a potent scavenger that suppresses levels of free radicals and cyclooxygenase-2 (COX-2) and contributes to reduced risk of colon cancer development.",180.16,"156-39-8",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/4-hydroxyphenylpyruvic-acid.html","C9H8O4","Free Base","4-HPPA","OC(=O)C(=O)CC1=CC=C(O)C=C1",1.128,2,1,3]
["S3168","cis-Resveratrol","d7","L3000-44","in 10mM DMSO","Apoptosis related,COX,DNA/RNA Synthesis,IκB/IKK,Lipoxygenase,Nrf2,Sirtuin","Immunology & Inflammation","cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.",228.24,"61434-67-1",{"v":46,"d":"46.00"},201.54,"<1","N/A","http://www.selleckchem.com/products/cis-resveratrol.html","C14H12O3","Free Base","cis-RESV, cRes, (Z)-Resveratrol","OC1=CC=C(C=C1)\\C=C/C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S3472","Metarrestin (ML246)","e7","L3000-44","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.",{"v":474.6,"d":"474.60"},"1443414-10-5",{"v":21,"d":"21.00"},44.25,"<1","N/A","http://www.selleckchem.com/products/metarrestin.html","C31H30N4O","Free Base","N/A","OC1CCC(CC1)N2C=NC3=C(C2=N)C(=C([N]3CC4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CC=C6",5.968,1,1,5]
["S3573","Trotabresib","f7","L3000-44","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Trotabresib(BMS-986378,CC-90010) is a reversible, orally active and central nervous system-penetrant inhibitor of bromodomain and extra-terminal (BET) proteins. CC-90010 is applied in the study for advanced solid tumors.",383.46,"1706738-98-8",{"v":77,"d":"77.00"},{"v":200.8,"d":"200.80"},"<1","N/A","http://www.selleckchem.com/products/cc-90010.html","C21H21NO4S","Free Base","BMS-986378,CC-90010","CN1C=C(C2=CC=CC=C2C1=O)C3=C(OCC4CC4)C=CC(=C3)[S](C)(=O)=O",2.741,4,0,5]
["S4418","Phenol Red sodium salt","g7","L3000-44","in 10mM DMSO","Dyes,Estrogen/progestogen Receptor","Others","Phenol Red sodium salt (Phenolsulfonephthalein sodium salt) is used ubiquitously as a pH indicator in tissue culture media ranging from 6.8 (yellow) to 8.2 (red). Phenol red binds to the estrogen receptor of MCF-7 human breast cancer cells.",376.36,"34487-61-1",{"v":75,"d":"75.00"},199.28,{"v":15,"d":"15.00"},39.86,"http://www.selleckchem.com/products/phenol-red-sodium-salt.html","C19H13NaO5S","Sodium salt","Phenolsulfonephthalein sodium salt","[Na+].OC1=CC=C(C=C1)C2(O[S](=O)(=O)C3=CC=CC=C23)C4=CC=C([O-])C=C4",{"v":2.82,"d":"2.820"},1,1,2]
["S4489","Tetraethylammonium chloride","h7","L3000-44","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.",{"v":165.7,"d":"165.70"},"56-34-8",{"v":33,"d":"33.00"},199.16,{"v":33,"d":"33.00"},199.16,"http://www.selleckchem.com/products/tetraethylammonium-chloride.html","C8H20ClN","Free Base","TEA chloride","[Cl-].CC[N+](CC)(CC)CC",-2.314,0,0,4]
["S4643","KB-R7943 mesylate","a8","L3000-44","in 10mM DMSO","Autophagy,JNK,NCX","Transmembrane Transporters","KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.",{"v":427.5,"d":"427.50"},"182004-65-5",{"v":86,"d":"86.00"},201.17,"<1","N/A","http://www.selleckchem.com/products/kb-r7943-mesylate.html","C17H21N3O6S2","Mesylate","N/A","C[S](O)(=O)=O.NC(=N)SCCC1=CC=C(OCC2=CC=C(C=C2)[N+]([O-])=O)C=C1",3.376,1,1,8]
["S4967","Ceritinib dihydrochloride","b8","L3000-44","in 10mM DMSO","ALK,IGF-1R,Serine/threonin kinase","Protein Tyrosine Kinase","Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.",631.06,"1380575-43-8",{"v":13,"d":"13.00"},{"v":20.6,"d":"20.60"},"<1","N/A","http://www.selleckchem.com/products/ceritinib-dihydrochloride.html","C28H38Cl3N5O3S","Dihydrochloride","Zykadia, LDK378 dihydrochloride","Cl.Cl.CC(C)OC1=C(NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4",7.243,5,3,9]
["S5080","Neticonazole","c8","L3000-44","in 10mM DMSO","Fungal","Microbiology","Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity.",302.43,"130726-68-0",{"v":60,"d":"60.00"},198.39,{"v":60,"d":"60.00"},198.39,"http://www.selleckchem.com/products/neticonazole.html","C17H22N2OS","Free Base","SS717","CCCCCOC1=CC=CC=C1C(=C\\SC)/[N]2C=CN=C2",3.456,2,0,8]
["S5190","Crizotinib hydrochloride","d8","L3000-44","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",{"v":486.8,"d":"486.80"},"1415560-69-8",{"v":97,"d":"97.00"},199.26,{"v":97,"d":"97.00"},199.26,"http://www.selleckchem.com/products/crizotinib-hydrochloride.html","C21H23Cl3FN5O","Hydrochloride","Xalkori, PF-02341066 hydrochloride","Cl.CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",4.075,3,2,5]
["S5738","Megestrol","e8","L3000-44","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.",342.47,"3562-63-8",{"v":68,"d":"68.00"},198.56,"<1","N/A","http://www.selleckchem.com/products/megestrol.html","C22H30O3","Free Base","Megace","CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C",3.126,2,0,1]
["S5958","Metformin","f8","L3000-44","in 10mM DMSO","AMPK,Apoptosis related,JNK,Mitophagy,p38 MAPK","PI3K/Akt/mTOR","Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",129.16,"657-24-9",{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},"http://www.selleckchem.com/products/metformin.html","C4H11N5","Free Base","1,1-Dimethylbiguanide","CN(C)C(=N)NC(N)=N",-0.742,0,2,3]
["S5978","Gallein","g8","L3000-44","in 10mM DMSO","Dyes,PI3K","PI3K/Akt/mTOR","Gallein (Pyrogallol phthalein) is an inhibitor of G protein βγ (G beta-gamma complex, Gβγ) subunit interaction with PI3 kinase. Gallein inhibits β-ionone effects and exhibits anti-tumor activity. Gallein can be used as a biological stain.",364.31,"2103-64-2",{"v":73,"d":"73.00"},200.38,"<1","N/A","http://www.selleckchem.com/products/gallein.html","C20H12O7","Free Base","Pyrogallol phthalein","OC1=C(O)C2=C(C=C1)C3(OC(=O)C4=CC=CC=C34)C5=C(O2)C(=C(O)C=C5)O",3.253,3,4,0]
["S7853","Pelabresib (CPI-0610)","h8","L3000-44","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Pelabresib (CPI-0610) is a potent and selective benzoisoxazoloazepine BET bromodomain inhibitor with an IC50 of 39 nM for BRD4-BD1 in TR-FRET assay and currently undergoing human clinical trials for hematological malignancies. CPI-0610 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",365.81,"1380087-89-7",{"v":73,"d":"73.00"},199.56,"<1","N/A","http://www.selleckchem.com/products/cpi-0610.html","C20H16ClN3O2","Free Base","N/A","CC1=NOC2=C1C3=CC=CC=C3C(=NC2CC(N)=O)C4=CC=C(Cl)C=C4",3.483,4,1,3]
["S8033","6-Iodopravadoline (AM630)","a9","L3000-44","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","6-Iodopravadoline (AM630) is a selective cannabinoid CB2 receptor antagonist with Ki of 31.2 nM.",504.36,"164178-33-0",{"v":50,"d":"50.00"},99.14,"<1","N/A","http://www.selleckchem.com/products/6-iodopravadoline.html","C23H25IN2O3","Free Base","N/A","COC1=CC=C(C=C1)C(=O)C2=C(C)[N](CCN3CCOCC3)C4=C2C=CC(=C4)I",4.267,3,0,6]
["S8920","(Rac)-JBJ-04-125-02","b9","L3000-44","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","(Rac)-JBJ-04-125-02 (JBJ-04-125-02 racemate) is a mutant-selective allosteric inhibitor of Epidermal growth factor receptor (EGFR) with potential anticancer activity.",543.61,"2140807-05-0",{"v":100,"d":"100.00"},183.96,"<1","N/A","http://www.selleckchem.com/products/jbj-04-125-02.html","C29H26FN5O3S","Free Base","JBJ-04-125-02 racemate","OC1=CC=C(F)C=C1C(N2CC3=C(C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)C2=O)C(=O)NC6=NC=CS6",3.415,3,3,6]
["S8932","Remdesivir (GS-5734)","c9","L3000-44","in 10mM DMSO","Antiviral,COVID-19,DNA/RNA Synthesis","Microbiology","Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.",602.58,"1809249-37-3",{"v":100,"d":"100.00"},165.95,"<1","N/A","http://www.selleckchem.com/products/remdesivir.html","C27H35N6O8P","Free Base","N/A","CCC(CC)COC(=O)C(C)N[P](=O)(OCC1OC(C#N)(C(O)C1O)C2=CC=C3[N]2N=CN=C3N)OC4=CC=CC=C4",2.174,7,4,14]
["S8948","SRX3207","d9","L3000-44","in 10mM DMSO","Epigenetic Reader Domain,PI3K,Syk","Angiogenesis","SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.",555.65,"2254693-15-5",{"v":33,"d":"33.00"},59.39,"<1","N/A","http://www.selleckchem.com/products/srx3207.html","C29H29N7O3S","Free Base","N/A","CC1=N[N](C=C1CN2CCC2)C3=CC=NC(=N3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7",{"v":4.59,"d":"4.590"},6,1,7]
["S8956","(Z)-4-Hydroxytamoxifen","e9","L3000-44","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","(Z)-4-Hydroxytamoxifen ((Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen) is a selective modulator of estrogen receptor (SERM) with IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor.",387.51,"68047-06-3",{"v":78,"d":"78.00"},201.29,"<1","N/A","http://www.selleckchem.com/products/z-4-hydroxytamoxifen.html","C26H29NO2","Free Base","(Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3",6.077,1,1,8]
["S8988","Rhosin hydrochloride","f9","L3000-44","in 10mM DMSO","Apoptosis related,Rho","Cell Cycle","Rhosin (G04) hydrochloride (HCl) is a potent, specific inhibitor of RhoA subfamily Rho GTPases with Kd of ~ 0.4 uM. Rhosin hydrochloride induces cell apoptosis.",394.86,"1281870-42-5",{"v":93,"d":"93.00"},235.53,{"v":93,"d":"93.00"},235.53,"http://www.selleckchem.com/products/rhosin-hydrochloride.html","C20H19ClN6O","Hydrochloride","G04 hydrochloride, Rhosin HCl","Cl.NC(CC1=C[NH]C2=CC=CC=C12)C(=O)N\\N=C\\C3=CC4=NC=CN=C4C=C3",2.237,4,3,5]
["S9609","Amcenestrant (SAR439859)","g9","L3000-44","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation.",554.48,"2114339-57-8",{"v":100,"d":"100.00"},180.35,"<1","N/A","http://www.selleckchem.com/products/sar439859.html","C31H30Cl2FNO3","Free Base","N/A","OC(=O)C1=CC2=C(C=C1)C(=C(CCC2)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(OC5CCN(CCCF)C5)C=C4",{"v":4.73,"d":"4.730"},2,0,8]
["S9667","Inobrodib (CCS-1477)","h9","L3000-44","in 10mM DMSO","Androgen Receptor,Epigenetic Reader Domain,Myc","Epigenetics","Inobrodib (CCS1477; CBP-IN-1; CBP/p300-IN-4）is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.",{"v":534.6,"d":"534.60"},"2222941-37-7",{"v":100,"d":"100.00"},187.06,"<1","N/A","http://www.selleckchem.com/products/ccs-1477-cbp-in-1-.html","C30H32F2N4O3","Free Base","CBP-IN-1, CBP/p300-IN-4","COC1CCC(CC1)[N]2C(=NC3=CC(=CC=C23)C4=C(C)ON=C4C)C5CCCC(=O)N5C6=CC(=C(F)C=C6)F",5.343,5,0,5]
["S9668","PKR-IN-C16","a10","L3000-44","in 10mM DMSO","Apoptosis related,eIF,Interleukins,PKR","ER stress & UPR","PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.",268.29,"608512-97-6",{"v":13,"d":"13.00"},48.46,"<1","N/A","http://www.selleckchem.com/products/pkr-in-c16.html","C13H8N4OS","Free Base","imoxin, C16, Imidazolo-oxindole PKR inhibitor C16","O=C1NC2=CC=C3N=CSC3=C2\\C1=C\\C4=CN=C[NH]4",0.993,3,2,1]
["S9721","Farudodstat","b10","L3000-44","in 10mM DMSO","AP-1,Apoptosis related,Dehydrogenase","Metabolism","Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.",356.32,"1035688-66-4",{"v":71,"d":"71.00"},199.26,"<1","N/A","http://www.selleckchem.com/products/aslan003.html","C19H14F2N2O3","Free Base","LAS 186323,ASLAN003","COC1=CC=CC(=C1)C2=CC(=C(NC3=NC=CC=C3C(O)=O)C(=C2)F)F",4.311,3,1,5]
["S9723","CDDO-Im","c10","L3000-44","in 10mM DMSO","Nrf2,PPAR","Immunology & Inflammation","CDDO-Im (CDDO-Imidazolide, RTA-403, TP-235) is an activator of nuclear factor erythroid 2–related factor 2 (Nrf2) and peroxisome proliferator-activated receptor (PPAR). CDDO-Im binds to PPARα and PPARγ with Ki of 232 nM and 344 nM, respectively. CDDO-Im inhibits inflammatory response and tumor growth in vivo.",541.72,"443104-02-7",{"v":56,"d":"56.00"},103.37,"<1","N/A","http://www.selleckchem.com/products/cddo-im.html","C34H43N3O3","Free Base","CDDO-Imidazolide, RTA-403, TP-235","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C5(C)C=C(C#N)C(=O)C(C)(C)C5CCC34C)C(=O)[N]6C=CN=C6",5.484,4,0,1]
["S9724","SZL P1-41","d10","L3000-44","in 10mM DMSO","Apoptosis related,E3 Ligase","Ubiquitin","SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.",420.52,"222716-34-9",{"v":5,"d":"5.00"},11.89,"<1","N/A","http://www.selleckchem.com/products/szl-p1-41.html","C24H24N2O3S","Free Base","N/A","CCC1=C(O)C(=C2OC=C(C(=O)C2=C1)C3=NC4=C(S3)C=CC=C4)CN5CCCCC5",5.048,3,1,4]
["S9742","Indisulam","e10","L3000-44","in 10mM DMSO","Carbonic Anhydrase,CDK","Metabolism","Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.",385.85,"165668-41-7",{"v":77,"d":"77.00"},199.56,"<1","N/A","http://www.selleckchem.com/products/indisulam.html","C14H12ClN3O4S2","Free Base","E7070","N[S](=O)(=O)C1=CC=C(C=C1)[S](=O)(=O)NC2=C3[NH]C=C(Cl)C3=CC=C2",{"v":1.98,"d":"1.980"},4,3,4]
["S9783","6-Aminonicotinamide","f10","L3000-44","in 10mM DMSO","Dehydrogenase","Metabolism","6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM.",137.14,"329-89-5",{"v":27,"d":"27.00"},196.88,"<1","N/A","http://www.selleckchem.com/products/6-aminonicotinamide.html","C6H7N3O","Free Base","6AN","NC(=O)C1=CC=C(N)N=C1",-0.526,2,2,1]
["S9786","BDTX-189","g10","L3000-44","in 10mM DMSO","EGFR,HER2,RIP kinase","Protein Tyrosine Kinase","BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.",561.03,"2414572-47-5",{"v":100,"d":"100.00"},178.24,"<1","N/A","http://www.selleckchem.com/products/bdtx-189.html","C29H29ClN6O4","Free Base","N/A","ClC1=C(OCC2=NC=CC=C2)C=CC(=C1)NC3=NC=NC4=C3C=C(NC(=O)C=C)C(=C4)OCCN5CCOCC5",4.401,7,2,11]
["S9806","DTHIB","h10","L3000-44","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities.",309.68,"897326-30-6",{"v":86,"d":"86.00"},277.71,"<1","N/A","http://www.selleckchem.com/products/dthib.html","C13H9ClFN3O3","Free Base","N/A","[O-][N+](=O)C1=CC(=CC=C1Cl)NC(=O)NC2=CC=C(F)C=C2",3.287,1,2,3]
["S9807","EN4","a11","L3000-44","in 10mM DMSO","Myc","Cell Cycle","EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.",416.47,"1197824-15-9",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://www.selleckchem.com/products/en4.html","C25H24N2O4","Free Base","N/A","CCOC1=CC=C(OC2=C(NC(=O)C3=CC=C(CNC(=O)C=C)C=C3)C=CC=C2)C=C1",4.332,4,2,9]
["S9864","Elimusertib (BAY-1895344)","b11","L3000-44","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.",375.43,"1876467-74-1",{"v":17,"d":"17.00"},45.28,"<1","N/A","http://www.selleckchem.com/products/elimusertib-bay-1895344-.html","C20H21N7O","Free Base","N/A","CC1COCCN1C2=CC(=C3C=CN=C(C4=CC=N[NH]4)C3=N2)C5=CC=N[N]5C",2.774,5,1,3]
["S0472","EC330","c11","L3000-44","in 10mM DMSO","Interleukins","Immunology & Inflammation","EC330 is a steroidal inhibitor of leukemia inhibitory factor (LIF, an interleukin 6 class cytokine). EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.",462.57,"2016795-77-8",{"v":12,"d":"12.00"},25.94,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ec330.html","C30H32F2O2","Free Base","N/A","CC12CC(C3=CC=C(C=C3)C4CC4)C5=C6CCC(=O)C=C6CCC5C1CCC2(O)C(F)(F)C#C",6.858,1,0,3]
["S0817","SKI-V","d11","L3000-44","in 10mM DMSO","Apoptosis related,PI3K,S1P Receptor,SPHK","Immunology & Inflammation","SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.",254.24,"24418-86-8",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ski-v.html","C15H10O4","Free Base","N/A","OC1=C(O)C=C(C=C1)C=C2OC3=CC=CC=C3C2=O",2.652,2,2,1]
["S0982","m-3M3FBS","e11","L3000-44","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells.",343.36,"200933-14-8",{"v":69,"d":"69.00"},200.96,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/m-3m3fbs.html","C16H16F3NO2S","Free Base","N/A","CC1=CC(=C(C(=C1)C)[S](=O)(=O)NC2=CC=CC(=C2)C(F)(F)F)C",4.718,2,1,4]
["S4453","NPD8733","f11","L3000-44","in 10mM DMSO","p97","Ubiquitin","NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.",309.32,"696655-62-6",{"v":31,"d":"31.00"},100.22,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/npd8733.html","C18H15NO4","Free Base","N/A","COC1=CC=C(C=C1)C(=O)C2=C(NC(C)=O)C3=CC=CC=C3O2",2.933,4,1,4]
["S6060","HPK1-IN-2","g11","L3000-44","in 10mM DMSO","FLT3,Serine/threonin kinase,Src","Metabolism","HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1, a serine/threonine Ste20-related protein kinase), Lck and Flt3 with IC50 of <0.05 μM, IC50 of <0.5 μM and IC50 of <0.05 μM, respectively. HPK1-IN-2 exhibits antitumor activity.",380.47,"2056122-11-1",{"v":76,"d":"76.00"},199.75,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/hpk1-in-2.html","C19H20N6OS","Free Base","N/A","CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(NC4=O)SC=C5",1.362,2,3,2]
["S6193","YUM70","h11","L3000-44","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.",398.84,"423145-35-1",{"v":80,"d":"80.00"},200.58,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/yum70.html","C21H19ClN2O4","Free Base","N/A","CCCC(=O)NC(C1=CC2=C(OCO2)C=C1)C3=CC(=C4C=CC=NC4=C3O)Cl",4.069,4,2,5]
["S6965","Bavdegalutamide (ARV-110)","a2","L3000-45","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.",812.29,"2222112-77-6",{"v":100,"d":"100.00"},123.11,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/arv-110.html","C41H43ClFN9O6","Free Base","N/A","FC1=CC2=C(C=C1N3CCN(CC3)CC4CCN(CC4)C5=NN=C(C=C5)C(=O)NC6CCC(CC6)OC7=CC=C(C#N)C(=C7)Cl)C(=O)N(C8CCC(=O)NC8=O)C2=O",4.677,8,2,9]
["S6966","MT-802","b2","L3000-45","in 10mM DMSO","BTK","Angiogenesis","MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).",787.82,"2231744-29-7",{"v":100,"d":"100.00"},126.93,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/mt-802.html","C41H41N9O8","Free Base","N/A","NC1=C2C(=NC=N1)[N](N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)C5CCN(CCOCCOCC(=O)NC6=CC7=C(C=C6)C(=O)N(C8CCC(=O)NC8=O)C7=O)CC5",2.152,11,3,14]
["S7647","Lucitanib (E3810) hydrochloride","c2","L3000-45","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Lucitanib (E-3810, AL3810) hydrochloride is a dual inhibitor of Vascular endothelial growth factor receptor (VEGFR) and Fibroblast growth factor receptor (FGFR). Lucitanib hydrochloride (E-3810, AL3810) potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50 of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.",479.96,"1058137-23-7",{"v":59,"d":"59.00"},122.93,{"v":59,"d":"59.00"},122.93,"http://www.selleckchem.com/products/lucitanib.html","C26H26ClN3O4","Hydrochloride","AL3810","[Cl-].CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=CC=NC4=CC(=C(OC)C=C34)OCC5([NH3+])CC5",-0.502,5,1,7]
["S9607","A939572","d2","L3000-45","in 10mM DMSO","SCD","Metabolism","A939572 is a potent and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.",387.86,"1032229-33-6",{"v":39,"d":"39.00"},100.55,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/a939572.html","C20H22ClN3O3","Free Base","N/A","CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl",2.629,3,2,4]
["S9776","AG-636","e2","L3000-45","in 10mM DMSO","Dehydrogenase","Metabolism","AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.",343.38,"1623416-31-8",{"v":35,"d":"35.00"},101.93,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ag-636.html","C21H17N3O2","Free Base","N/A","C[N]1N=NC2=CC(=CC(=C12)C(O)=O)C3=CC=C(C=C3)C4=CC=CC=C4C",4.793,3,0,3]
["S9779","Emavusertib (CA-4948)","f2","L3000-45","in 10mM DMSO","FLT3,IRAK","Immunology & Inflammation","Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity.",{"v":491.5,"d":"491.50"},"1801344-14-8",{"v":49,"d":"49.00"},99.69,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ca-4948.html","C24H25N7O5","Free Base","N/A","CC1=NC=CC(=C1)C2=NC(=CO2)C(=O)NC3=C(N=C4N=C(OC4=C3)N5CCOCC5)N6CCC(O)C6",1.031,8,2,5]
["S9835","OSMI-1","g2","L3000-45","in 10mM DMSO","Transferase","Metabolism","OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 μM for full length human OGT (ncOGT).",563.64,"1681056-61-0",{"v":100,"d":"100.00"},177.42,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/osmi-1.html","C28H25N3O6S2","Free Base","N/A","COC1=CC=CC=C1C(N[S](=O)(=O)C2=CC3=C(NC(=O)C=C3)C=C2)C(=O)N(CC4=CC=CO4)CC5=CC=CS5",{"v":3.22,"d":"3.220"},6,2,10]
["S9859","BSJ-4-116","h2","L3000-45","in 10mM DMSO","CDK","Cell Cycle","BSJ-4-116 is a specific degrader of cyclin-dependent kinase 12 (CDK12). BSJ-4-116 exhibits potent antiproliferative effects.",837.38,"2519823-34-6",{"v":100,"d":"100.00"},119.42,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/bsj-4-116.html","C40H49ClN8O8S","Free Base","N/A","CC(C)[S](=O)(=O)C1=C(NC2=NC(=NC=C2Cl)NC3CCCN(CCCCCCCNC(=O)COC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)C3)C=CC=C1",4.985,10,4,18]
["S9871","BTYNB","a3","L3000-45","in 10mM DMSO","Myc,NF-κB","Cell Cycle","BTYNB (BTYNB IMP1 Inhibitor, MDK6620) is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). BTYNB disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association.",309.18,"304456-62-0",{"v":62,"d":"62.00"},200.53,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/btynb.html","C12H9BrN2OS","Free Base","BTYNB IMP1 Inhibitor, MDK6620","NC(=O)C1=CC=CC=C1N=CC2=CC=C(Br)S2",{"v":2.95,"d":"2.950"},2,1,3]
["S9880","MS140","b3","L3000-45","in 10mM DMSO","CDK","Cell Cycle","MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).",{"v":760.8,"d":"760.80"},"2229974-83-6",{"v":10,"d":"10.00"},13.14,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ms140.html","C39H40N10O7","Free Base","N/A","CC(=O)C1=C(C)C2=C(N=C(NC3=NC=C(C=C3)N4CCN(CC4)C(=O)CNC5=CC=CC6=C5C(=O)N(C7CCC(=O)NC7=O)C6=O)N=C2)N(C8CCCC8)C1=O",2.188,10,3,9]
["S9882","PFI-90","c3","L3000-45","in 10mM DMSO","Histone Demethylase","Epigenetics","PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.",214.22,"53995-62-3",{"v":43,"d":"43.00"},200.73,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pfi-90.html","C11H10N4O","Free Base","N/A","O=C(NNC1=NC=CC=C1)C2=NC=CC=C2",1.303,3,2,3]
["S9885","MYLS22","d3","L3000-45","in 10mM DMSO","Others","Others","MYLS22  is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity.",443.52,"306959-01-3",{"v":81,"d":"81.00"},182.63,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/myls22.html","C24H21N5O2S","Free Base","N/A","CN1N(C(=O)C(=C1C)NC(=O)C2=CC3=C(S2)[N](N=C3C)C4=CC=CC=C4)C5=CC=CC=C5",3.247,3,1,4]
["S9900","JNJ-63576253 (TRC-253)","e3","L3000-45","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM.  JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.",538.97,"2110428-64-1",{"v":100,"d":"100.00"},185.54,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/jnj-63576253-trc-253.html","C23H22ClF3N6O2S","Free Base","N/A","Cl.FC(F)(F)C1=CC(=CN=C1C#N)N2C(=O)C3(CCC3)N(C2=S)C4=CN=C(OC5CCNCC5)C=C4",4.367,4,1,5]
["S9919","Pimonidazole","f3","L3000-45","in 10mM DMSO","Others","Others","Pimonidazole (Ro 03-8799) is a novel hypoxia marker used for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.",254.29,"70132-50-2",{"v":51,"d":"51.00"},200.56,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pimonidazole.html","C11H18N4O3","Free Base","Ro 03-8799","OC(CN1CCCCC1)C[N]2C=CN=C2[N+]([O-])=O",0.904,1,1,5]
["E0010","Hypocrellin A","g3","L3000-45","in 10mM DMSO","Antiviral,Bacterial,PKC","TGF-beta/Smad","Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.",546.52,"77029-83-5",{"v":25,"d":"25.00"},45.74,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/hypocrellin-a.html","C30H26O10","Free Base","N/A","COC1=CC(=C2C(=O)C(=C3CC(C)(O)C(C(C)=O)C4=C(OC)C(=O)C5=C(O)C=C(OC)C6=C1C2=C3C4=C56)OC)O",1.955,7,2,5]
["E0011","Linderalactone","h3","L3000-45","in 10mM DMSO","Bcl-2,JAK,STAT","Apoptosis","Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.",244.29,"728-61-0",{"v":49,"d":"49.00"},200.58,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/linderalactone.html","C15H16O3","Free Base","N/A","CC/1=C\\CCC2=CC(OC2=O)C3=C(C1)OC=C3C",3.391,3,0,0]
["E0022","Ophiopogonin D","a4","L3000-45","in 10mM DMSO","AMPK,Immunology & Inflammation related,NF-κB","PI3K/Akt/mTOR","Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.",855.02,"945619-74-9",{"v":100,"d":"100.00"},116.96,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ophiopogonin-d.html","C44H70O16","Free Base","OJV-VI, Deacetylophiopogonin C","CC1CCC2(OC1)OC3CC4C5CC=C6CC(O)CC(OC7OC(C)C(O)C(OC8OCC(O)C(O)C8O)C7OC9OC(C)C(O)C(O)C9O)C6(C)C5CCC4(C)C3C2C",0.454,8,8,6]
["E0035","CP-31398 Dihydrochloride","b4","L3000-45","in 10mM DMSO","p53","Apoptosis","CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.",435.39,"1217195-61-3",{"v":87,"d":"87.00"},199.82,{"v":87,"d":"87.00"},199.82,"http://www.selleckchem.com/products/cp-31398-dihydrochloride.html","C22H28Cl2N4O","Dihydrochloride","N/A","Cl.Cl.COC1=CC=C(C=C1)/C=C/C2=NC3=CC=CC=C3C(=N2)NCCCN(C)C",4.772,3,1,8]
["S6812","Z-Guggulsterone","c4","L3000-45","in 10mM DMSO","Apoptosis related,Immunology & Inflammation related","Immunology & Inflammation","Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.",312.45,"39025-23-5",{"v":5,"d":"5.00"},{"v":16,"d":"16.00"},"<1","N/A","http://www.selleckchem.com/products/z-guggulsterone.html","C21H28O2","Free Base","(Z)-Guggulsterone","C/C=C/1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",{"v":4.03,"d":"4.030"},2,0,0]
["S9706","OT-82","d4","L3000-45","in 10mM DMSO","NAMPT","Metabolism","OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.",424.47,"1800487-55-1",{"v":85,"d":"85.00"},200.25,"<1","N/A","http://www.selleckchem.com/products/ot-82.html","C26H21FN4O","Free Base","N/A","FC1=CC=C(C=C1)C#CC2=CC(=CC=C2C3=CC=NC=C3)C(=O)NCCCC4=C[NH]N=C4",{"v":4.53,"d":"4.530"},3,2,8]
["S9782","Sulfopin","e4","L3000-45","in 10mM DMSO","Others","Metabolism","Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.",{"v":281.8,"d":"281.80"},"2451481-08-4",{"v":56,"d":"56.00"},198.72,{"v":3,"d":"3.00"},10.65,"http://www.selleckchem.com/products/sulfopin.html","C11H20ClNO3S","Free Base","PIN1-3","CC(C)(C)CN(C1CC[S](=O)(=O)C1)C(=O)CCl",{"v":1.09,"d":"1.090"},3,0,4]
["S9954","SGN-2FF","f4","L3000-45","in 10mM DMSO","Transferase","Metabolism","SGN‐2FF (2-fluorofucose) is an orally bioavailable small‐molecule inhibitor of fucosyltransferase that demonstrated encouraging preclinical antitumor activity in mouse models.",166.15,"2089647-47-0",{"v":33,"d":"33.00"},198.62,{"v":33,"d":"33.00"},198.62,"http://www.selleckchem.com/products/sgn-2ff.html","C6H11FO4","Free Base","2-fluorofucose","CC1OC(O)C(F)C(O)C1O",{"v":-0.69,"d":"-0.690"},1,2,0]
["E0108","LQZ-7I","g4","L3000-45","in 10mM DMSO","Survivin","Apoptosis","LQZ-7I is a novel selectively inhibitor of survivin dimerization with IC50s of 4.8 µM and 3.1 µM in prostate cancer cell lines PC-3 and  C4-2, respectively. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.",348.35,"195822-23-2",{"v":70,"d":"70.00"},200.95,"<1","N/A","http://www.selleckchem.com/products/lqz-7i.html","C₂₀H₁₄F₂N₄","Free Base","N/A","FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1",{"v":5.88,"d":"5.880"},2,2,4]
["E0112","INH154","h4","L3000-45","in 10mM DMSO","Others","Cell Cycle","INH154 is a potent inhibitor of Nek2 and Hec1 binding. NH154 binds to Hec1, thus blocking Hec1 phosphorylation by NEK2, and kills cancer cells at the nanomolar range.",392.52,"1587705-63-2",{"v":79,"d":"79.00"},201.26,"<1","N/A","http://www.selleckchem.com/products/inh154.html","C22H24N4OS","Free Base","N/A","CC1=C(C(=CC(=C1)N2CCCCC2)C)C3=CSC(=N3)NC(=O)C4=CC=NC=C4",{"v":4.46,"d":"4.460"},3,1,4]
["S0057","N-Succinimidyl-S-acetylthioacetate (SATA)","a5","L3000-45","in 10mM DMSO","Others","Others","N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent which introduces thiol-groups into protein molecules. N-Succinimidyl-S-acetylthioacetate (SATA) adds sulfhydryl groups to proteins and other amine-containing molecules in a protected form.",231.23,"76931-93-6",{"v":46,"d":"46.00"},198.94,"<1","N/A","http://www.selleckchem.com/products/n-succinimidyl-s-acetylthioacetate-sata.html","C8H9NO5S","free base","N/A","CC(=O)SCC(=O)ON1C(=O)CCC1=O",-0.692,5,0,5]
["S0090","NS6180","b5","L3000-45","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","NS-6180 is a highly selective inhibitor of KCa3.1 ion channel with IC50 value of 9 nM, which inhibits T cell activation and inflammation.",323.33,"353262-04-1",{"v":65,"d":"65.00"},201.03,"<1","N/A","http://www.selleckchem.com/products/ns6180.html","C16H12F3NOS","free base","N/A","FC(F)(F)C1=CC(=CC=C1)CN2C(=O)CSC3=CC=CC=C23",3.909,1,0,3]
["S0150","ML239","c5","L3000-45","in 10mM DMSO","Others","Metabolism","ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line.",{"v":346.6,"d":"346.60"},"1378872-36-6",{"v":69,"d":"69.00"},199.08,"<1","N/A","http://www.selleckchem.com/products/ml239.html","C13H10Cl3N3O2","free base","N/A","ClC1=CC(=C(OCC(=O)N\\N=C\\C2=CC=C[NH]2)C(=C1)Cl)Cl",3.897,3,2,5]
["S0307","BTR-1","d5","L3000-45","in 10mM DMSO","Apoptosis related","Apoptosis","BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.",249.35,"18331-34-5",{"v":13,"d":"13.00"},52.14,"<1","N/A","http://www.selleckchem.com/products/btr-1.html","C12H11NOS2","free base","N/A","CCN1C(=S)S\\C(=C/C2=CC=CC=C2)C1=O",3.396,1,0,2]
["S0311","SKA-31","e5","L3000-45","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","SKA-31(Naphtho[1,2-d]thiazol-2-ylamine) is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively.",200.26,"40172-65-4",{"v":40,"d":"40.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/ska-31.html","C11H8N2S","free base","Naphtho[1,2-d]thiazol-2-ylamine","NC1=NC2=C3C=CC=CC3=CC=C2S1",2.617,1,1,0]
["S0510","Myoseverin","f5","L3000-45","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Myoseverin is a microtubule-binding trisubstituted purine, reversibly altering cellular function, directly binds tubulin and disrupts the structure of the microtubule cytoskeleton resulting in myotube fission at 20 μM.",432.52,"267402-71-1",{"v":87,"d":"87.00"},201.15,"<1","N/A","http://www.selleckchem.com/products/myoseverin.html","C24H28N6O2","free base","N/A","COC1=CC=C(CNC2=NC(=C3N=C[N](C(C)C)C3=N2)NCC4=CC=C(OC)C=C4)C=C1",4.509,5,2,9]
["S0730","(Rac)-Antineoplaston A10","g5","L3000-45","in 10mM DMSO","Ras","Apoptosis","(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.",246.26,"77658-84-5",{"v":49,"d":"49.00"},198.98,"<1","N/A","http://www.selleckchem.com/products/-rac--antineoplaston-a10.html","C13H14N2O3","free base","N/A","O=C1CCC(NC(=O)CC2=CC=CC=C2)C(=O)N1",0.307,3,2,3]
["S0739","PD184161","h5","L3000-45","in 10mM DMSO","MEK","MAPK","PD184161, an orally active MEK inhibitor with IC50 of 10-100 nM in a time- and concentration-dependent manner, inhibits cell proliferation and induces apoptosis, and produces depressive-like behavior.",557.56,"212631-67-9",{"v":100,"d":"100.00"},179.35,"<1","N/A","http://www.selleckchem.com/products/pd184161.html","C17H13BrClF2IN2O2","free base","N/A","FC1=C(Br)C=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl",5.656,2,2,6]
["S0762","SC 236","a6","L3000-45","in 10mM DMSO","COX","Immunology & Inflammation","SC-236 is a potent, selective, orally active inhibitor of COX-2 with an IC50 of 10 nM and approximately 18,000-fold COX-2 selectivity.",401.79,"170569-86-5",{"v":80,"d":"80.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/sc-236.html","C16H11ClF3N3O2S","free base","N/A","N[S](=O)(=O)C1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(Cl)C=C3)C(F)(F)F",4.606,3,1,4]
["S0763","Tyrphostin AG1433","b6","L3000-45","in 10mM DMSO","PDGFR,VEGFR","Protein Tyrosine Kinase","Tyrphostin AG1433 (AG1433, SU1433) is a selective platelet-derived growth factor receptor β (PDGFRβ) and vascular endothelial growth factor receptor 2 (VEGFR-2, Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively.",{"v":266.3,"d":"266.30"},"168835-90-3",{"v":53,"d":"53.00"},199.02,"<1","N/A","http://www.selleckchem.com/products/tyrphostin-ag1433.html","C16H14N2O2","free base","SU1433, AG1433","CC1=C(C)C=C2N=C(C=NC2=C1)C3=CC=C(O)C(=C3)O",3.729,2,2,1]
["S0767","NL-1","c6","L3000-45","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.",335.46,"188532-26-5",{"v":67,"d":"67.00"},199.73,"<1","N/A","http://www.selleckchem.com/products/nl-1.html","C18H25NO3S","free base","N/A","CC(C)(C)C1=C(O)C(=CC(=C1)CC2SC(=O)NC2=O)C(C)(C)C",4.644,2,2,4]
["S0770","Camalexin","d6","L3000-45","in 10mM DMSO","Fungal,ROS","Microbiology","Camalexin, a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae), can induce reactive oxygen species (ROS) production. Camalexin has antibacterial, antifungal, antiproliferative and anticancer activities.",200.26,"135531-86-1",{"v":40,"d":"40.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/camalexin.html","C11H8N2S","free base","N/A","[NH]1C=C(C2=NC=CS2)C3=C1C=CC=C3",2.504,1,1,1]
["S0871","Gusacitinib (ASN-002)","e6","L3000-45","in 10mM DMSO","JAK,Syk","Angiogenesis","Gusacitinib (ASN-002) is a novel and potent dual inhibitor of spleen tyrosine kinase (SYK) and Janus kinases (JAK) with IC50 values of 5-46 nM in biochemical assays.",460.53,"1425381-60-7",{"v":92,"d":"92.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/gusacitinib.html","C24H28N8O2","free base","N/A","OC1CCN(CC1)C2=CC=C(NC3=NC(=NC4=C3C(=O)NN=C4)N5CCC(CC5)CC#N)C=C2",2.467,4,3,5]
["S0888","Rsva 405","f6","L3000-45","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Rsva 405, a novel small-molecule activator of AMPK, is a potent inhibitor of adipogenesis and thus may have therapeutic potential against obesity.",312.37,"140405-36-3",{"v":62,"d":"62.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/rsva-405.html","C17H20N4O2","free base","N/A","CCN(CC)C1=CC=C(/C=N/NC(=O)C2=CC=NC=C2)C(=C1)O",{"v":2.15,"d":"2.150"},3,2,6]
["S0901","SP141","g6","L3000-45","in 10mM DMSO","MDM2/MDMX","Apoptosis","SP141 is a new class of MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation, and reduces levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation and ability to form tumors in nude mice. SP141 inhibits human pancreatic cancer cell growth with IC50 values of less than 0.5 μM (0.38–0.50 μM) in a p53-independent manner.",324.38,"1253491-42-7",{"v":65,"d":"65.00"},200.38,"<1","N/A","http://www.selleckchem.com/products/sp141.html","C22H16N2O","free base","N/A","COC1=CC2=C([NH]C3=C2C=CN=C3C4=C5C=CC=CC5=CC=C4)C=C1",5.011,2,1,2]
["S0936","Aloin B","h6","L3000-45","in 10mM DMSO","Antiviral","Microbiology","Aloin B (Isobarbaloin), isolated from Aloe vera, is one isomer of Aloin and has anti-hepatitis B virus (HBV) acyivity.",418.39,"28371-16-6",{"v":84,"d":"84.00"},200.77,{"v":-1,"d":"-1.00"},-2.39,"http://www.selleckchem.com/products/aloin-b.html","C21H22O9","free base","Isobarbaloin","OCC1OC(C(O)C(O)C1O)C2C3=CC=CC(=C3C(=O)C4=C2C=C(CO)C=C4O)O",-0.404,2,7,3]
["S0986","SC-1","a7","L3000-45","in 10mM DMSO","STAT","JAK/STAT","SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.",{"v":431.8,"d":"431.80"},"1313019-65-6",{"v":86,"d":"86.00"},199.17,"<1","N/A","http://www.selleckchem.com/products/sc-1.html","C21H13ClF3N3O2","free base","1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7","FC(F)(F)C1=CC(=CC=C1Cl)NC(=O)NC2=CC=C(OC3=CC=C(C=C3)C#N)C=C2",5.568,2,2,5]
["S1239","TAK-960","b7","L3000-45","in 10mM DMSO","PLK","Cell Cycle","TAK-960 is a novel, investigational, orally bioavailable, potent, and selective PLK1 inhibitor that has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1).",{"v":561.6,"d":"561.60"},"1137868-52-0",{"v":13,"d":"13.00"},23.15,"<1","N/A","http://www.selleckchem.com/products/tak-960.html","C27H34F3N7O3","free base","N/A","COC1=C(NC2=NC=C3N(C)C(=O)C(F)(F)CN(C4CCCC4)C3=N2)C=C(F)C(=C1)C(=O)NC5CCN(C)CC5",3.451,5,2,6]
["S1349","SC99","c7","L3000-45","in 10mM DMSO","JAK,STAT","JAK/STAT","SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway by docking into the ATP-binding pocket of JAK2, also inhibits phosphorylation of JAK2and STAT3 with no effects on the other kinases associated with STAT3 signaling.",336.15,"882290-02-0",{"v":67,"d":"67.00"},199.32,"<1","N/A","http://www.selleckchem.com/products/sc99.html","C15H8Cl2FN3O","free base","N/A","FC1=C(Cl)C=C(N/N=C(C#N)/C(=O)C2=CC=C(Cl)C=C2)C=C1",4.864,2,1,4]
["S2089","Fenoldopam","d7","L3000-45","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA .",305.76,"67227-56-9",{"v":77,"d":"77.00"},251.83,{"v":10,"d":"10.00"},32.71,"http://www.selleckchem.com/products/fenoldopam-corlopam.html","C16H16ClNO3","free base","SKF 82526","OC1=CC=C(C=C1)C2CNCCC3=C(Cl)C(=C(O)C=C23)O",3.053,0,4,1]
["S2174","Hydroxyflutamide (Hydroxyniphtholide)","e7","L3000-45","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Hydroxyflutamide (SCH-16423, Hydroxyniphtholide) is an androgen receptor (AR) antagonist and possesses an IC50 of 0.7 μM for the androgen receptor.",292.21,"52806-53-8",{"v":58,"d":"58.00"},198.49,"<1","N/A","http://www.selleckchem.com/products/hydroxyflutamide-sch-16423-hydroxyniphtholide.html","C11H11F3N2O4","free base","Hydroxy-flutamide, SCH-16423","CC(C)(O)C(=O)NC1=CC=C(C(=C1)C(F)(F)F)[N+]([O-])=O",{"v":1.91,"d":"1.910"},1,1,4]
["S2880","GW843682X","f7","L3000-45","in 10mM DMSO","PLK","Cell Cycle","GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ~30 other kinases.",477.46,"660868-91-7",{"v":95,"d":"95.00"},198.97,"<1","N/A","http://www.selleckchem.com/products/gw-843682x.html","C22H18F3N3O4S","free base","N/A","COC1=C(OC)C=C2[N](C=NC2=C1)C3=CC(=C(S3)C(N)=O)OCC4=C(C=CC=C4)C(F)(F)F",4.684,5,1,8]
["S2917","Cutamesine Dihydrochloride","g7","L3000-45","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.",441.43,"165377-44-6",{"v":22,"d":"22.00"},49.84,{"v":88,"d":"88.00"},199.35,"http://www.selleckchem.com/products/sa-4503.html","C23H32N2O2.2HCl","Dihydrochloride","SA4503 dihydrochloride, AGY94806 dihydrochloride","Cl.Cl.COC1=C(OC)C=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1",5.274,2,0,9]
["S3374","Verubulin hydrochloride","h7","L3000-45","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.",{"v":315.8,"d":"315.80"},"917369-31-4",{"v":56,"d":"56.00"},200.47,{"v":56,"d":"56.00"},200.47,"http://www.selleckchem.com/products/verubulin-hydrochloride.html","C17H18ClN3O","hydrochloride","MPC 6827 hydrochloride","Cl.COC1=CC=C(C=C1)N(C)C2=C3C=CC=CC3=NC(=N2)C",4.004,3,0,3]
["S3534","AM966","a8","L3000-45","in 10mM DMSO","LPA Receptor","GPCR & G Protein","AM966 is a high affinity, selective, oral Lysophosphatidic acid receptor 1 (LPA1) antagonist, which can inhibit LPA-stimulated intracellular calcium release (IC50=17 nM, by Ca flux assay).",490.93,"1228690-19-4",{"v":98,"d":"98.00"},199.62,"<1","N/A","http://www.selleckchem.com/products/am966.html","C27H23ClN2O5","free base","N/A","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(C=C2)C3=CC=C(CC(O)=O)C=C3)C4=C(Cl)C=CC=C4",5.948,5,1,8]
["S3552","SIS3","b8","L3000-45","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.",453.53,"1009104-85-1",{"v":91,"d":"91.00"},200.65,"<1","N/A","http://www.selleckchem.com/products/sis3.html","C28H27N3O3","free base","N/A","COC1=CC2=C(CN(CC2)C(=O)\\C=C\\C3=C([N](C)C4=NC=CC=C34)C5=CC=CC=C5)C=C1OC",5.429,4,0,5]
["S3586","URB937","c8","L3000-45","in 10mM DMSO","FAAH","Metabolism","URB937 is an orally active and peripherally restricted FAAH inhibitor with IC50 of 26.8 nM and increases anandamide levels.",{"v":354.4,"d":"354.40"},"1357160-72-5",{"v":71,"d":"71.00"},200.34,"<1","N/A","http://www.selleckchem.com/products/urb937.html","C20H22N2O4","free base","N/A","NC(=O)C1=CC=CC(=C1)C2=CC(=CC=C2O)OC(=O)NC3CCCCC3",{"v":3.73,"d":"3.730"},3,3,5]
["S5893","Poloxin","d8","L3000-45","in 10mM DMSO","PLK","Cell Cycle","Poloxin is a non-ATP competitive Polo-like Kinase 1 polo-box domain (Plk1 PBD) inhibitor with an apparent IC50 of 4.8 μM. Poloxin's IC50 values against the PBDs of Plk2 and Plk3 as Plk1 are approximately 4-fold and 11-fold higher, respectively in fluorescence polarization assays.",297.35,"321688-88-4",{"v":59,"d":"59.00"},198.42,"<1","N/A","http://www.selleckchem.com/products/poloxin.html","C18H19NO3","free base","N/A","CC(C)C1=CC(=N/OC(=O)C2=CC=CC=C2C)/C(=CC1=O)C",4.329,4,0,4]
["S6004","CCI-007","e8","L3000-45","in 10mM DMSO","Bcl-2","Apoptosis","CCI-007 is a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.",336.36,"939228-52-1",{"v":67,"d":"67.00"},199.19,"<1","N/A","http://www.selleckchem.com/products/cci-007.html","C15H16N2O5S","free base","N/A","CCOC(=O)COC1=CC=C(C=C1OC)\\C=C2\\SC(=NC2=O)N",2.019,6,1,7]
["S6397","Thalidomide-NH-C4-NH-Boc","f8","L3000-45","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Thalidomide-NH-C4-NH-Boc is a novel, potent, and selective class of Bromodomain-containing protein 4 (BRD4) and Bromodomain-containing protein 2 (BRD2) degrader for the development of therapeutics to treat cancers.",444.48,"2093388-52-2",{"v":89,"d":"89.00"},200.23,"<1","N/A","http://www.selleckchem.com/products/thalidomide-nh-c4-nh-boc.html","C22H28N4O6","free base","N/A","CC(C)(C)OC(=O)NCCCCNC1=CC=CC2=C1C(=O)N(C3CCC(=O)NC3=O)C2=O",1.315,6,3,9]
["S6810","Diarylpropionitrile (DPN)","g8","L3000-45","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β (ERβ) agonist with EC50 of 0.85 nM, 72-fold more selective for ERβ than ERα.",239.27,"1428-67-7",{"v":48,"d":"48.00"},200.61,"<1","N/A","http://www.selleckchem.com/products/diarylpropionitrile.html","C15H13NO2","free base","2,3-bis (4-Hydroxyphenyl) Propionitrile","OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1",{"v":3.21,"d":"3.210"},0,2,3]
["S6973","TJ191","h8","L3000-45","in 10mM DMSO","Others","Apoptosis","TJ191 is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.",255.38,"1522415-97-9",{"v":51,"d":"51.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://www.selleckchem.com/products/tj191.html","C13H21NO2S","free base","N/A","CCCCCCCC1=CC(=C(N)S1)C(=O)OC",3.818,2,1,8]
["S7002","Zotiraciclib","a9","L3000-45","in 10mM DMSO","FLT3,JAK","Cell Cycle","Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.",372.46,"937270-47-8",{"v":74,"d":"74.00"},355.41,"<1","N/A","http://www.selleckchem.com/products/sb1317-tg02.html","C23H24N4O","free base","SB1317 (TG02)","CN1C/C=C/CCOC2=CC(=CC=C2)C3=CC=NC(=NC4=CC=CC(=C4)C1)N3",3.296,3,1,0]
["S7274","HLY78","b9","L3000-45","in 10mM DMSO","Apoptosis related","Apoptosis","HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway.",267.32,"854847-61-3",{"v":53,"d":"53.00"},198.26,"<1","N/A","http://www.selleckchem.com/products/hly78.html","C17H17NO2","free base","N/A","CCC1=C2N(C)CC3=CC4=C(OCO4)C=C3C2=CC=C1",3.974,2,0,1]
["S7478","AF38469","c9","L3000-45","in 10mM DMSO","Others","Neuronal Signaling","AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.",324.26,"1531634-31-7",{"v":65,"d":"65.00"},200.46,"<1","N/A","http://www.selleckchem.com/products/af38469.html","C15H11F3N2O3","free base","N/A","CC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2C(O)=O)C(F)(F)F",2.857,3,1,4]
["S7715","FIIN-3","d9","L3000-45","in 10mM DMSO","FGFR","Angiogenesis","FIIN-3 is an irreversible inhibitor of FGFR with an IC50 of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.",691.61,"1637735-84-2",{"v":100,"d":"100.00"},144.59,"<1","N/A","http://www.selleckchem.com/products/fiin-3.html","C34H36Cl2N8O4","free base","N/A","COC1=CC(=C(Cl)C(=C1Cl)NC(=O)N(CC2=CC=C(NC(=O)C=C)C=C2)C3=NC=NC(=C3)NC4=CC=C(C=C4)N5CCN(C)CC5)OC",6.395,6,3,11]
["S9738","RS504393","e9","L3000-45","in 10mM DMSO","CCR","Microbiology","RS504393, an extremely selective CC chemokine receptor (CCR) 2 antagonist with IC50 of 98 nM, also targets multiple receptors for inhibition of CCR2b and CCR1 receptors when administrated in higher concentration.",{"v":417.5,"d":"417.50"},"300816-15-3",{"v":10,"d":"10.00"},23.95,"<1","N/A","http://www.selleckchem.com/products/rs504393.html","C25H27N3O3","free base","N/A","CC1=CC=C2NC(=O)OC3(CCN(CCC4=C(C)OC(=N4)C5=CC=CC=C5)CC3)C2=C1",3.815,4,1,4]
["S9819","C75","f9","L3000-45","in 10mM DMSO","Others","Metabolism","C75 (4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid) , a more stable synthetic mimic of cerulenin, inhibits fatty-acid synthase (FAS/FASN) with an IC50 of 15.53 μM and has potential therapeutic effects in several cancer models. C75 is also a potent CPT1A activator.",254.32,"218137-86-1",{"v":51,"d":"51.00"},200.53,"<1","N/A","http://www.selleckchem.com/products/c-75.html","C14H22O4","free base","N/A","CCCCCCCCC1OC(=O)C(=C)C1C(O)=O",3.711,3,0,8]
["S9833","BAY-3827","g9","L3000-45","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration.",468.53,"2377576-35-5",{"v":12,"d":"12.00"},25.61,"<1","N/A","http://www.selleckchem.com/products/bay-3827.html","C27H25FN6O","free base","N/A","CCC1=CC=CC=C1C(=O)NC2=N[NH]C3=C2C=C(C4C(=C(C)N(C)C(=C4C#N)C)C#N)C(=C3C)F",5.056,2,2,4]
["S9849","5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA)","h9","L3000-45","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","5-(N-Ethyl-N-isopropyl)-Amiloride (EIPA) acts as an inhibitor of macropinocytosis and sodium-hydrogen exchangers(NHE)  (IC50=0.033μg/mL). EIPA blocks the activity of Na(+)/H(+) exchanger, which are plasma membrane proteins implicated in all forms of macropinocytosis.",299.76,"1154-25-2",{"v":60,"d":"60.00"},200.16,{"v":2,"d":"2.00"},6.67,"http://www.selleckchem.com/products/5-n-ethyl-n-isopropyl-amiloride-eipa.html","C11H18ClN7O","free base","N/A","CCN(C(C)C)C1=C(Cl)N=C(C(=N1)N)C(=O)NC(N)=N",1.236,3,3,5]
["S9892","HM43239","a10","L3000-45","in 10mM DMSO","FLT3","Angiogenesis","HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s' of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.",501.07,"2569527-64-4",{"v":50,"d":"50.00"},99.79,"<1","N/A","http://www.selleckchem.com/products/hm43239.html","C29H33ClN6","free base","N/A","CC1CN(CC(C)N1)CC2=CC(=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC(=C5)C)C6CC6",6.586,2,3,6]
["S9893","Venadaparib(IDX-1197)","b10","L3000-45","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Venadaparib (IDX-1197), a potent PARP1/2 inhibitor with IC50 values of 1.4 nM and 1.0 nM respectively, prevents the repair of DNA single-strand breaks (SSB) and promotes the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells.",406.45,"1681017-83-3",{"v":81,"d":"81.00"},199.29,"<1","N/A","http://www.selleckchem.com/products/venadaparib-idx-1197.html","C23H23FN4O2","free base","N/A","FC1=C(C=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1)C(=O)N4CC(CNC5CC5)C4",{"v":2.12,"d":"2.120"},3,2,6]
["S9905","SU0268","c10","L3000-45","in 10mM DMSO","OGG1","DNA Damage/DNA Repair","SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1), with the IC50 of 0.059 μM.",475.56,"2210228-45-6",{"v":95,"d":"95.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/su0268.html","C26H25N3O4S","free base","N/A","NC(=O)C1=CC=CC(=C1)C2=CC=C(C=C2)[S](=O)(=O)NC3=CC4=C(CCCN4C(=O)C5CC5)C=C3",3.453,4,2,6]
["S9929","VB124","d10","L3000-45","in 10mM DMSO","MCT","Transmembrane Transporters","VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism.",426.89,"2230186-18-0",{"v":85,"d":"85.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/vb124.html","C23H23ClN2O4","free base","N/A","CC(C)(OCC1=N[N](C2=C(Cl)C=CC=C2)C(=C1)C3=CC(=CC=C3)OC4CC4)C(O)=O",{"v":5.3,"d":"5.300"},4,0,8]
["S9934","KA2507","e10","L3000-45","in 10mM DMSO","HDAC","Epigenetics","KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.",322.32,"1636894-46-6",{"v":64,"d":"64.00"},198.56,{"v":64,"d":"64.00"},198.56,"http://www.selleckchem.com/products/ka2507.html","C16H14N6O2","free base","N/A","ONC(=O)C1=CC=C(CN(C2=NC=CN=C2)C3=NC=CN=C3)C=C1",{"v":0.66,"d":"0.660"},5,1,5]
["S9943","ErSO","f10","L3000-45","in 10mM DMSO","Others","ER stress & UPR","ErSO activates the anticipatory unfolded protein response (a-UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro.",453.33,"2407860-35-7",{"v":91,"d":"91.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/erso.html","C22H13F6NO3","free base","N/A","OC1=CC=C(C=C1)C2(C(=O)NC3=C(C=CC=C23)C(F)(F)F)C4=CC=C(OC(F)(F)F)C=C4",6.583,2,2,5]
["S9945","G140","g10","L3000-45","in 10mM DMSO","cGAS","Immunology & Inflammation","G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.",379.24,"2369751-07-3",{"v":76,"d":"76.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://www.selleckchem.com/products/g140.html","C17H16Cl2N4O2","free base","N/A","C[N]1C=CC(=N1)C2=C3C4=C(CCN(C4)C(=O)CO)[NH]C3=C(Cl)C(=C2)Cl",2.789,2,2,2]
["S9963","paquinimod","h10","L3000-45","in 10mM DMSO","COVID-19,SARS-CoV","Microbiology","Paquinimod (ABR 25757), a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.",350.41,"248282-01-1",{"v":70,"d":"70.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/paquinimod.html","C21H22N2O3","free base","ABR 25757","CCN(C(=O)C1=C(O)C2=C(CC)C=CC=C2N(C)C1=O)C3=CC=CC=C3",3.162,2,1,4]
["S9965","M435-1279","a11","L3000-45","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","M435-1279 is a UBE2T inhibitor, inhibiting the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.",419.48,"1359431-16-5",{"v":9,"d":"9.00"},21.46,"<1","N/A","http://www.selleckchem.com/products/m435-1279.html","C18H17N3O5S2","free base","N/A","N[S](=O)(=O)C1=CC=C(NC(=O)C2=C(O)C3=C(NC2=O)SC4=C3CCCC4)C=C1",1.334,4,4,3]
["S9973","Flumatinib (HH-GV-678)","b11","L3000-45","in 10mM DMSO","Bcr-Abl,c-Kit,PDGFR","Angiogenesis","Flumatinib (HH-GV-678) is a novel inhibitor of Bcr-Abl with IC50 values of 1.2  nM, 307.6  nM and 665.5  nM for c-Abl, PDGFRβand c-Kit, respectively.",562.59,"895519-90-1",{"v":100,"d":"100.00"},177.75,"<1","N/A","http://www.selleckchem.com/products/flumatinib-hh-gv-678.html","C29H29F3N8O","free base","HH-GV678","CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CN=C(C)C(=C3)NC4=NC(=CC=N4)C5=CN=CC=C5",3.808,5,2,8]
["E0051","SJ-172550","c11","L3000-45","in 10mM DMSO","MDM2/MDMX","Apoptosis","SJ 172550 is the first MDMX inhibitor that binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.",428.87,"431979-47-4",{"v":86,"d":"86.00"},200.53,"<1","N/A","http://www.selleckchem.com/products/sj-172550.html","C₂₂H₂₁ClN₂O₅","free base","N/A","CCOC1=C(OCC(=O)OC)C(=CC(=C1)\\C=C2/C(=NN(C2=O)C3=CC=CC=C3)C)Cl",4.456,6,0,8]
["E0068","NiCur","d11","L3000-45","in 10mM DMSO","Histone Acetyltransferase,p53","Epigenetics","NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.",324.38,"63476-70-0",{"v":8,"d":"8.00"},24.66,"<1","N/A","http://www.selleckchem.com/products/nicur.html","C22H16N2O","free base","N/A","O=C\\1/C(CCCC1=C\\C2=CC(=CC=C2)C#N)=C/C3=CC(=CC=C3)C#N",4.895,1,0,2]
["E0079","Compound W","e11","L3000-45","in 10mM DMSO","Secretase","Proteases","Compound W (3,5-Bis(4-nitrophenoxy)benzoic acid) is a 3,3'-diiodothyronine sulfate (3,3'-T2S) cross-reactive material in maternal serum, which can inhibit γ-secretase.",396.31,"173550-33-9",{"v":79,"d":"79.00"},199.34,"<1","N/A","http://www.selleckchem.com/products/compound-w.html","C19H12N2O8","free base","3,5-Bis(4-nitrophenoxy)benzoic acid","OC(=O)C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+]([O-])=O)OC3=CC=C(C=C3)[N+]([O-])=O",4.369,3,0,7]
["E0081","FIDAS-3","f11","L3000-45","in 10mM DMSO","Transferase","Metabolism","FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.",259.29,"1266684-01-8",{"v":52,"d":"52.00"},200.55,"<1","N/A","http://www.selleckchem.com/products/fidas-3.html","C₁₆H₁₅F₂N","free base","N/A","CN(C)C1=CC=C(C=C1)/C=C/C2=C(F)C=CC=C2F",5.123,0,0,3]
["E0097","Mericitabine","g11","L3000-45","in 10mM DMSO","HCV Protease","Proteases","Mericitabine (RG 7128, R-7128, PSI 6130 diisobutyrate) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.",399.41,"940908-79-2",{"v":80,"d":"80.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://www.selleckchem.com/products/mericitabine.html","C18H26FN3O6","free base","RG 7128, R-7128, PSI 6130 diisobutyrate","CC(C)C(=O)OCC1OC(N2C=CC(=NC2=O)N)C(C)(F)C1OC(=O)C(C)C",1.766,7,1,8]
["E0190","Invert sugar","h11","L3000-45","in 10mM DMSO","Others","Others","Invert Sugar is a popular sweetener.",360.31,"8013-17-0","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/invert-sugar.html","C12H24O12","free base","N/A","OCC(O)C(O)C(O)C(O)C=O.OCC(O)C(O)C(O)C(=O)CO",-5.664,2,10,10]
["E0211","Dihydroberberine","a2","L3000-46","in 10mM DMSO","Immunology & Inflammation related,NF-κB","NF-κB","Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.",337.37,"483-15-8",{"v":34,"d":"34.00"},100.78,{"v":-1,"d":"-1.00"},-2.96,"http://www.selleckchem.com/products/dihydroberberine.html","C20H19NO4","free base","N/A","COC1=CC=C2C=C3N(CCC4=C3C=C5OCOC5=C4)CC2=C1OC",{"v":3.15,"d":"3.150"},4,0,2]
["E0233","14-Deoxy-11,12-didehydroandrographolide","b2","L3000-46","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees with hypotensive, anti-inflammatory, anti-asthma, and anti-cancer activities.",332.43,"42895-58-9",{"v":66,"d":"66.00"},198.54,{"v":-1,"d":"-1.00"},-3.01,"http://www.selleckchem.com/products/14-deoxy-11-12-didehydroandrographolide.html","C20H28O4","free base","deAND","CC1(CO)C(O)CCC2(C)C1CCC(=C)C2/C=C/C3=CCOC3=O",3.313,2,2,3]
["E0245","Rhamnose","c2","L3000-46","in 10mM DMSO","Others","Others","Rhamnose(L-Rhamnose) is an important 6-deoxy sugar present in many natural products, glycoproteins, and structural polysaccharides.",164.16,"3615-41-6",{"v":33,"d":"33.00"},201.02,{"v":-1,"d":"-1.00"},-6.09,"http://www.selleckchem.com/products/rhamnose.html","C6H12O5","free base","L-Rhamnose","CC(O)C(O)C(O)C(O)C=O",-1.903,1,4,4]
["E0246","β-Anhydroicaritin","d2","L3000-46","in 10mM DMSO","Others","Endocrinology & Hormones","β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has antiosteoporosis, estrogen regulation and antitumor properties.",368.38,"38226-86-7",{"v":9,"d":"9.00"},24.43,{"v":-1,"d":"-1.00"},-2.71,"http://www.selleckchem.com/products/beta-anhydroicaritin.html","C21H20O6","free base","N/A","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C4OC(C)(C)CCC4=C3O2",3.437,4,2,2]
["E0247","Militarine","e2","L3000-46","in 10mM DMSO","Others","Neuronal Signaling","Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.",726.72,"58139-23-4",{"v":100,"d":"100.00"},{"v":137.6,"d":"137.60"},{"v":-1,"d":"-1.00"},-1.38,"http://www.selleckchem.com/products/militarine.html","C34H46O17","free base","N/A","CC(C)CC(O)(CC(=O)OCC1=CC=C(OC2OC(CO)C(O)C(O)C2O)C=C1)C(=O)OCC3=CC=C(OC4OC(CO)C(O)C(O)C4O)C=C3",-0.194,8,8,17]
["E0334","BAMB-4","f2","L3000-46","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","BAMB-4 (ITPKA-IN-C14) is a new type of membrane permeable ITPKA inhibitor, and IC50 is 37 μM in the Kinase ADP-Glo assay.",252.27,"891025-25-5",{"v":50,"d":"50.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://www.selleckchem.com/products/bamb-4.html","C15H12N2O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NC2=NOC3=CC=CC=C23",3.293,3,1,2]
["E0338","AKI603","g2","L3000-46","in 10mM DMSO","Aurora Kinase","Cell Cycle","AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.",409.45,"1432515-73-5",{"v":82,"d":"82.00"},200.27,"<1","N/A","http://www.selleckchem.com/products/aki603.html","C19H23N9O2","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)NC4=CC=C(C=C4)[N;v5](=O)=O",3.893,3,3,6]
["E0376","DPPE fumarate","h2","L3000-46","in 10mM DMSO","Others","Others","DPPE fumarate (Tesmilifene fumarate) is a novel potentiator of chemotherapy, which is found to potentiate a wide range of cytotoxics and to protect normal cells.",399.48,"1185241-83-1",{"v":80,"d":"80.00"},200.26,{"v":80,"d":"80.00"},200.26,"http://www.selleckchem.com/products/dppe-fumarate.html","C19H25NO.C4H4O4","fumarate","Tesmilifene fumarate","CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.OC(=O)\\C=C\\C(O)=O",2.362,3,0,10]
["E0378","PAP-1","a3","L3000-46","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","PAP-1 (5-(4-phenoxybutoxy)psoralen), a Kv1.3 antagonist with an EC50 of 2 nM, inhibits the proliferation of human T cells and suppresses delayed type hypersensitivity in rats.",350.37,"870653-45-5",{"v":70,"d":"70.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/pap-1.html","C21H18O5","free base","5-(4-Phenoxybutoxy)psoralen","O=C1OC2=CC3=C(C=CO3)C(=C2C=C1)OCCCCOC4=CC=CC=C4",4.461,5,0,7]
["E0380","Hepln-13","b3","L3000-46","in 10mM DMSO","Serine/threonin kinase","Metabolism","Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM, can be used for the research of metastatic prostate cancer.",{"v":325.2,"d":"325.20"},"64369-13-7",{"v":65,"d":"65.00"},199.88,"<1","N/A","http://www.selleckchem.com/products/hepln-13.html","C17H13BrN2","free base","N/A","BrC1=CC=C(C=C1)C2NC3=CC=CC4=CC=CC(=C34)N2",4.706,0,2,1]
["E0394","YK 3-237","c3","L3000-46","in 10mM DMSO","p53,Sirtuin","Epigenetics","YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.",372.18,"1215281-19-8",{"v":74,"d":"74.00"},198.83,"<1","N/A","http://www.selleckchem.com/products/yk-3-237.html","C19H21BO7","free base","N/A","COC1=C(OC)C(=CC(=C1)C(=O)/C=C/C2=CC=C(OC)C(=C2)B(O)O)OC",{"v":3.59,"d":"3.590"},5,0,8]
["E0395","Vercirnon","d3","L3000-46","in 10mM DMSO","CCR","GPCR & G Protein","Vercirnon (GSK1605786A, CCX-282, Traficet-EN), an orally bioavailable, selective, and potent antagonist of CCR9, is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9.",444.93,"698394-73-9",{"v":45,"d":"45.00"},101.14,"<1","N/A","http://www.selleckchem.com/products/vercirnon.html","C22H21ClN2O4S","free base","GSK-1605786, CCX-282, Traficet-EN","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(Cl)C=C2C(=O)C3=CC=[N](=O)C=C3",3.791,3,1,6]
["E0400","AS1949490","e3","L3000-46","in 10mM DMSO","SHIP","Metabolism","AS1949490, a competitive inhibitor of 5'-lipid phosphatase SHIP2 with IC50 values of 0.62 µM and 0.34 µM for human (Ki value is 0.44 µM) and mouse respectively, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons.",371.88,"1203680-76-5",{"v":74,"d":"74.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/as1949490.html","C20H18ClNO2S","free base","N/A","CC(NC(=O)C1=C(OCC2=CC=C(Cl)C=C2)C=CS1)C3=CC=CC=C3",5.184,2,1,6]
["E0401","BI6015","f3","L3000-46","in 10mM DMSO","Others","Metabolism","BI6015, a hepatocyte nuclear factor 4α (HNF4α) antagonist, induces loss of HNF4α expression and hepatic steatosis in vivo. BI6015 is cytotoxic to human hepatocellular carcinoma (HCC).",331.35,"93987-29-2",{"v":33,"d":"33.00"},99.59,"<1","N/A","http://www.selleckchem.com/products/bi6015.html","C15H13N3O4S","free base","N/A","CC1=CC=C(C=C1[S](=O)(=O)[N]2C(=NC3=CC=CC=C23)C)[N+]([O-])=O",3.344,3,0,3]
["E0459","Robinetin","g3","L3000-46","in 10mM DMSO","DNA/RNA Synthesis,Integrase","Microbiology","Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manne, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.",302.24,"490-31-3",{"v":60,"d":"60.00"},198.52,"<1","N/A","http://www.selleckchem.com/products/robinetin.html","C15H10O7","free base","3,3',4',5',7-Pentahydroxyflavone","OC1=CC=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["E0466","Adarotene","h3","L3000-46","in 10mM DMSO","Others","Cell Cycle","Adarotene (ST1926) causes a dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 µM, causes cell accumulation in G1/S or S phase of cell cycle depending on tumor cells, exhibiting a potent antiproliferative activity.",374.47,"496868-77-0",{"v":75,"d":"75.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/adarotene.html","C25H26O3","free base","ST1926","OC(=O)/C=C/C1=CC=C(C=C1)C2=CC=C(O)C(=C2)C34CC5CC(CC(C5)C3)C4",5.613,1,1,4]
["E0469","GW 610","a4","L3000-46","in 10mM DMSO","Others","Metabolism","GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines.",289.33,"872726-44-8",{"v":3,"d":"3.00"},10.37,"<1","N/A","http://www.selleckchem.com/products/gw-610.html","C15H12FNO2S","free base","NSC 721648","COC1=CC=C(C=C1OC)C2=NC3=CC(=CC=C3S2)F",4.011,3,0,3]
["E0474","7BIO","b4","L3000-46","in 10mM DMSO","CDK,GSK-3","Cell Cycle","7-bromoindirubin-3-oxime (7BIO), an indirubin derivative derived from indirubin-3-oxime, possesses inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β), also potently inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, and activation of astrocytes and microglia.",356.17,"916440-85-2",{"v":71,"d":"71.00"},199.34,"<1","N/A","http://www.selleckchem.com/products/7bio.html","C16H10BrN3O2","free base","7-bromoindirubin-3-oxime","O\\N=C1\\C(NC2=CC=CC=C12)=C/3C(=O)NC4=C(Br)C=CC=C34",2.692,2,2,0]
["E0480","MRT-81","c4","L3000-46","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells, exerting potent hedgehog (Hh) signaling pathway inhibiting activity.",555.64,"1263132-08-6",{"v":100,"d":"100.00"},179.97,"<1","N/A","http://www.selleckchem.com/products/mrt-81.html","C31H29N3O5S","free base","N/A","COC1=C(OC)C(=CC(=C1)C(=O)NC(=S)NC2=CC=C(C)C(=C2)NC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)OC",6.506,5,3,10]
["E0483","Calmidazolium chloride","d4","L3000-46","in 10mM DMSO","ATPase,PDE","Metabolism","Calmidazolium chloride (R 24571) is a calmodulin (CaM) antagonist, antagonizing CaM-stimulated fraction of rat brain phosphodiesterase and CaM-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively, also shows a CaM-binding Kd value of 3 nM.",{"v":687.7,"d":"687.70"},"57265-65-3",{"v":100,"d":"100.00"},145.41,"<1","N/A","http://www.selleckchem.com/products/calmidazolium-chloride.html","C31H23Cl6N2O.Cl","Chloride","R 24571","[Cl-].ClC1=CC=C(C=C1)C([N]2C=C[N+](=C2)CC(OCC3=CC=C(Cl)C=C3Cl)C4=C(Cl)C=C(Cl)C=C4)C5=CC=C(Cl)C=C5",8.838,1,0,9]
["E0484","CNQX","e4","L3000-46","in 10mM DMSO","GluR","Neuronal Signaling","CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is an AMPA and kainate receptor antagonist with IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively. CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.",232.15,"115066-14-3",{"v":46,"d":"46.00"},198.15,"<1","N/A","http://www.selleckchem.com/products/cnqx.html","C9H4N4O4","free base","6-cyano-7-nitroquinoxaline-2,3-dione","[O-][N+](=O)C1=CC2=C(NC(=O)C(=O)N2)C=C1C#N",-0.176,2,2,1]
["E0486","C-021","f4","L3000-46","in 10mM DMSO","CCR","Immunology & Inflammation","C-021 is a potent CCR4 antagonist with IC50 values are 0.14 μM and 39 nM  for inhibition of chemotaxis in human and mouse respectively.",467.65,"864289-85-0",{"v":94,"d":"94.00"},201.01,"<1","N/A","http://www.selleckchem.com/products/c-021.html","C27H41N5O2","free base","N/A","COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCCCCC3)N4CCC(CC4)N5CCCCC5",5.728,4,1,6]
["E0487","SP-8356","g4","L3000-46","in 10mM DMSO","Others","NF-κB","SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.",300.35,"1454885-45-0",{"v":60,"d":"60.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/sp-8356.html","C18H20O4","free base","N/A","COC1=C(O)C(=CC(=C1)/C=C/C2=CC(=O)C3CC2C3(C)C)O",3.815,2,2,3]
["E0500","Firocoxib (ML 1785713)","h4","L3000-46","in 10mM DMSO","COX","Immunology & Inflammation","Firocoxib (ML 1785713) is a cyclooxygenase (COX)-2 inhibitor and a nonsteroidal anti-inflammatory drug. In vitro firocoxib inhibits COX-1 and COX-2 with an IC50 of 7.5 mM and 0.13 mM respectively in feline blood.",{"v":336.4,"d":"336.40"},"189954-96-9",{"v":67,"d":"67.00"},199.17,"<1","N/A","http://www.selleckchem.com/products/firocoxib.html","C17H20O5S","free base","ML 1785713","CC1(C)OC(=O)C(=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3CC3",2.483,5,0,5]
["E0501","Senicapoc (ICA-17043)","a5","L3000-46","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Senicapoc (ICA-17043) is a Gardos channel(Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.",323.34,"289656-45-7",{"v":65,"d":"65.00"},201.03,"<1","N/A","http://www.selleckchem.com/products/senicapoc-ica-17043.html","C20H15F2NO","free base","N/A","NC(=O)C(C1=CC=CC=C1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3",4.221,1,1,4]
["E0527","Norgestimate","b5","L3000-46","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity.",{"v":369.5,"d":"369.50"},"35189-28-7",{"v":74,"d":"74.00"},200.27,"<1","N/A","http://www.selleckchem.com/products/norgestimate.html","C23H31NO3","free base","N/A","CCC12CCC3C(CCC4=C/C(CCC34)=N/O)C1CCC2(OC(C)=O)C#C",5.218,3,0,3]
["E0528","Flecainide","c5","L3000-46","in 10mM DMSO","Others","Neuronal Signaling","Flecainide is a common medication used to help restore and maintain sinus rhythm in patients with atrial fibrillation.",414.34,"54143-55-4",{"v":83,"d":"83.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/flecainide.html","C17H20F6N2O3","free base","N/A","FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC2CCCCN2",3.568,3,2,9]
["E0530","Prednicarbate","d5","L3000-46","in 10mM DMSO","Others","Endocrinology & Hormones","Prednicarbate (Dermatop) is a medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.",488.57,"73771-04-7",{"v":98,"d":"98.00"},200.59,"<1","N/A","http://www.selleckchem.com/products/prednicarbate.html","C27H36O8","free base","Dermatop","CCOC(=O)OC1(CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C)C(=O)COC(=O)CC",3.677,7,1,9]
["E0531","TMS","e5","L3000-46","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive human cytochrome P450s B1 (CYP1B1) inhibitor with an IC50 of 6 nM.",300.35,"24144-92-1",{"v":60,"d":"60.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/tms.html","C18H20O4","free base","(E)-2,3',4,5'-tetramethoxystilbene","COC1=CC=C(\\C=C\\C2=CC(=CC(=C2)OC)OC)C(=C1)OC",{"v":3.75,"d":"3.750"},4,0,6]
["E0609","Methyl methanesulfonate","f5","L3000-46","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.",110.13,"66-27-3","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/methyl-methanesulfonate.html","C2H6O3S","free base","MMS","CO[S](C)(=O)=O",-0.375,1,0,1]
["E0650","γ-Terpinene","g5","L3000-46","in 10mM DMSO","Antioxidant","Apoptosis","γ-Terpinene (γ-TPN), a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly.,",136.23,"99-85-4","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/gamma-terpinen.html","C10H16","free base","γ-TPN","CC(C)C1=CCC(=CC1)C",3.448,0,0,1]
["E0653","Trans-ferulic acid","h5","L3000-46","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Trans-ferulic acid is  a potent activator of AMPKunder high glucose condition.",194.18,"537-98-4","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/trans-ferulic-acid.html","C10H10O4","free base","N/A","COC1=C(O)C=CC(=C1)\\C=C\\C(O)=O",2.403,2,1,3]
["E0656","7-Methylcoumarin","a6","L3000-46","in 10mM DMSO","Antibiotics","Microbiology","7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.",160.17,"2445-83-2",{"v":32,"d":"32.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/7-methylcoumarin.html","C10H8O2","free base","N/A","CC1=CC2=C(C=C1)C=CC(=O)O2",2.386,2,0,0]
["E0671","Deacetylasperulosidic acid","b6","L3000-46","in 10mM DMSO","Antioxidant,SOD","Immunology & Inflammation","Deacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice.",390.34,"14259-55-3",{"v":78,"d":"78.00"},199.83,{"v":19,"d":"19.00"},48.68,"http://www.selleckchem.com/products/deacetylasperulosidic-acid.html","C16H22O11","free base","N/A","OCC1OC(OC2OC=C(C3C(O)C=C(CO)C23)C(O)=O)C(O)C(O)C1O",-3.326,4,6,5]
["E0704","Esaxerenone (CS-3150)","c6","L3000-46","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Esaxerenone (CS-3150), a selective nonsteroidal mineralocorticoid receptor (MR) antagonist, binds to mineralocorticoid receptor and inhibits (3)H-aldosterone binding to mineralocorticoid receptor with an IC50 value of 9.4 nM. Esaxerenone (CS-3150) also has the property of increasing the likelihood of albuminuria returning to normal levels and reducing progression of albuminuria to higher levels.",466.48,"1632006-28-0",{"v":93,"d":"93.00"},199.37,{"v":-1,"d":"-1.00"},-2.14,"http://www.selleckchem.com/products/esaxerenone.html","C22H21F3N2O4S","free base","N/A","CC1=C([N](CCO)C=C1C(=O)NC2=CC=C(C=C2)[S](C)(=O)=O)C3=CC=CC=C3C(F)(F)F",4.139,3,2,7]
["E0707","Nomegestrol Acetate","d6","L3000-46","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Nomegestrol Acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.",370.48,"58652-20-3",{"v":74,"d":"74.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/nomegestrol-acetate.html","C23H30O4","free base","N/A","CC(=O)OC1(CCC2C3C=C(C)C4=CC(=O)CCC4C3CCC12C)C(C)=O",3.299,4,0,3]
["E0749","Coumalic acid","e6","L3000-46","in 10mM DMSO","Anti-infection","Microbiology","Coumalic acid is a valuable platform compound which can be prepared from malic acid, can be used in the flavours, fragrances and cosmetics industries, as polymer components, and as pharmaceutical scaffolds displaying anti-bronchial and -malarial activity.",140.09,"500-05-0",{"v":28,"d":"28.00"},199.87,{"v":2,"d":"2.00"},14.28,"http://www.selleckchem.com/products/coumalic-acid.html","C6H4O4","free base","N/A","OC(=O)C1=COC(=O)C=C1",-0.087,3,0,1]
["E0750","Dihydrouracil","f6","L3000-46","in 10mM DMSO","Others","Others","Dihydrouracil (5,6-Dihydrouracil) is an intermediate in the catabolism of uracil. Dihydrouracil (5,6-Dihydrouracil) can be used as a standard for ureido group in the colorimentric assay of transfer ribonucleic acid (tRNA).",{"v":114.1,"d":"114.10"},"504-07-4",{"v":23,"d":"23.00"},201.58,{"v":11,"d":"11.00"},96.41,"http://www.selleckchem.com/products/dihydrouracil.html","C4H6N2O2","free base","5,6-Dihydrouracil","O=C1CCNC(=O)N1",-0.913,2,2,0]
["E0758","Silydianin","g6","L3000-46","in 10mM DMSO","phosphatase","Metabolism","Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities.",482.44,"29782-68-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/silydianin.html","C25H22O10","free base","N/A","COC1=C(O)C=CC(=C1)C2C3COC4(O)C3C(=CC2C4=O)C5OC6=CC(=CC(=C6C(=O)C5O)O)O",1.059,5,4,3]
["E0760","Neotuberostemonine","h6","L3000-46","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Neotuberostemonine (NTS), one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, has a significant effect on BLM-induced pulmonary fibrosis by inhibiting macrophage recruitment and M2 polarization protective effect.",{"v":375.5,"d":"375.50"},"143120-46-1",{"v":75,"d":"75.00"},199.73,"<1","N/A","http://www.selleckchem.com/products/neotuberostemonine.html","C22H33NO4","free base","NTS","CCC1C2CCCCN3C(CC(C4C(C)C(=O)OC14)C23)C5CC(C)C(=O)O5",3.603,4,0,2]
["E0779","Paprotrain","a7","L3000-46","in 10mM DMSO","DYRK,Kinesin","Cell Cycle","Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.",245.28,"57046-73-8",{"v":49,"d":"49.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/paprotrain.html","C16H11N3","free base","N/A","N#C\\C(=C/C1=CN=CC=C1)C2=C[NH]C3=CC=CC=C23",2.798,1,1,2]
["E0781","BAZ1A-IN-1","b7","L3000-46","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein), exerting a Kd value of 0.52 μM against BAZ1A bromodomain, shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A.",340.36,"941521-45-5",{"v":68,"d":"68.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/baz1a-in-1.html","C16H12N4O3S","free base","N/A","[O-][N+](=O)C1=CC(=CC=C1)NC(=O)NC2=NC(=CS2)C3=CC=CC=C3",3.361,2,2,4]
["E0783","SM-7368","c7","L3000-46","in 10mM DMSO","MMP,NF-κB","NF-κB","SM-7368 is a potent NF-κB inhibitor that targets downstream of MAPK p38 activation, also inhibits TNF-α-induced MMP-9 upregulation.",328.69,"380623-76-7",{"v":66,"d":"66.00"},{"v":200.8,"d":"200.80"},"<1","N/A","http://www.selleckchem.com/products/sm-7368.html","C10H5ClN4O5S","free base","N/A","[O-][N+](=O)C1=CN=C(NC(=O)C2=CC=C(C(=C2)Cl)[N+]([O-])=O)S1",2.189,2,1,4]
["E0786","N-Desmethyltamoxifen","d7","L3000-46","in 10mM DMSO","Glucosylceramide Synthase,PKC","TGF-beta/Smad","N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.",357.49,"31750-48-8",{"v":72,"d":"72.00"},{"v":201.4,"d":"201.40"},"<1","N/A","http://www.selleckchem.com/products/n-desmethyltamoxifen.html","C25H27NO","free base","N/A","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCNC)C=C3",5.783,1,1,8]
["E0789","SC-58125","e7","L3000-46","in 10mM DMSO","COX","Immunology & Inflammation","SC-58125 is a potent and selective inhibitor of human cyclooxygenase 2 (hCOX-2) and triple mutant of hCOX-2, with an IC50 of 0.04 μM and 1 µM, respectively.",384.35,"162054-19-5",{"v":77,"d":"77.00"},200.34,"<1","N/A","http://www.selleckchem.com/products/sc-58125.html","C17H12F4N2O2S","free base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(F)C=C3)C(F)(F)F",4.968,3,0,4]
["E0790","ILK-IN-3","f7","L3000-46","in 10mM DMSO","Integrin","Cytoskeletal Signaling","ILK-IN-3 is an integrin linked kinase (ILK) inhibitor with antitumor activity.",232.24,"6975-75-3",{"v":46,"d":"46.00"},198.07,"<1","N/A","http://www.selleckchem.com/products/ilk-in-3.html","C10H12N6O","free base","N/A","COC1=CC=C(C=C1)N=NC2=C(N)[NH]N=C2N",1.797,4,3,3]
["E0792","SW-106065","g7","L3000-46","in 10mM DMSO","Others","Metabolism","SW-106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST), which can inhibit ATP consumption of sporadic MPNST and other models of MPNST with an EC50 of 1 µM.",204.25,"62289-81-0",{"v":41,"d":"41.00"},200.73,"<1","N/A","http://www.selleckchem.com/products/sw-106065.html","C10H8N2OS","free base","N/A","O=C(NC1=CC=CN=C1)C2=CC=CS2",1.417,2,1,2]
["E0793","G5-7","h7","L3000-46","in 10mM DMSO","JAK","JAK/STAT","G5-7 is an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2.",383.39,"939681-36-4",{"v":38,"d":"38.00"},99.12,"<1","N/A","http://www.selleckchem.com/products/g5-7.html","C22H19F2NO3","free base","N/A","CCOC(=O)N1CC(=C/C2=CC=CC=C2F)/C(=O)C(/C1)=C\\C3=CC=CC=C3F",{"v":4.57,"d":"4.570"},3,0,4]
["E0795","COH-SR4","a8","L3000-46","in 10mM DMSO","AMPK,mTOR","PI3K/Akt/mTOR","COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.",350.03,"73439-19-7",{"v":70,"d":"70.00"},199.98,"<1","N/A","http://www.selleckchem.com/products/coh-sr4.html","C13H8Cl4N2O","free base","N/A","ClC1=CC(=CC(=C1)NC(=O)NC2=CC(=CC(=C2)Cl)Cl)Cl",{"v":5.18,"d":"5.180"},1,2,2]
["E0808","BI-6C9","b8","L3000-46","in 10mM DMSO","Apoptosis related","Apoptosis","BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons.",{"v":471.6,"d":"471.60"},"791835-21-7",{"v":94,"d":"94.00"},199.32,"<1","N/A","http://www.selleckchem.com/products/bl-6C9.html","C23H25N3O4S2","free base","N/A","COC1=CC=C(C=C1)[S;v6](=O)(=O)NCCCC(=O)NC2=CC=C(SC3=CC=C(N)C=C3)C=C2",3.302,4,3,10]
["E0812","CXD101","c8","L3000-46","in 10mM DMSO","HDAC","NF-κB","CXD101 (HDAC-IN-4) is a potent, selective and orally active class I histone deacetylase (HDAC) inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively.",403.52,"934828-12-3",{"v":81,"d":"81.00"},200.73,"<1","N/A","http://www.selleckchem.com/products/cxd101.html","C24H29N5O","free base","HDAC-IN-4","C[N]1C=C(CN2CCC(CC2)C3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N)C(=N1)C",3.075,2,2,5]
["E0814","Masitinib mesylate","d8","L3000-46","in 10mM DMSO","c-Kit,FAK,FGFR,PDGFR,Src","Protein Tyrosine Kinase","Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit with IC50 of 200 nM for human recombinant c-Kit, also inhibits PDGFRα/β with IC50s of 540/800 nM, Lyn with IC50 of 510 nM for LynB, and, to a lesser extent, FGFR3 and FAK.",594.75,"1048007-93-7",{"v":100,"d":"100.00"},168.14,{"v":100,"d":"100.00"},168.14,"https://www.selleckchem.com/products/masitinib-mesylate.html","C28H30N6OS.CH4O3S","Mesylate","AB-1010 mesylate","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC(=CS4)C5=CN=CC=C5.C[S](O)(=O)=O",4.795,3,2,7]
["E0822","AST-1306","e8","L3000-46","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AST-1306 (Allitinib) is an orally active and irreversible EGFR, ErbB2 and   inhibitor with IC50s of 0.5, 3 and 0.8 nM, respectively.",448.88,"897383-62-9",{"v":90,"d":"90.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://www.selleckchem.com/products/ast-1306.html","C24H18ClFN4O2","free base","Allitinib","FC1=CC=CC(=C1)COC2=C(Cl)C=C(NC3=NC=NC4=C3C=C(NC(=O)C=C)C=C4)C=C2",5.732,4,2,7]
["E0828","Mitonafide","f8","L3000-46","in 10mM DMSO","Bacterial","Microbiology","Mitonafide inhibits the activity of Mycobacterium tuberculosis NAD+ dependent DNA ligase A at concentrations of 50 µM.",313.31,"54824-17-8",{"v":32,"d":"32.00"},102.14,"<1","N/A","http://www.selleckchem.com/products/mitonafide.html","C16H15N3O4","free base","N/A","CN(C)CCN1C(=O)C2=CC=CC3=C2C(=CC(=C3)[N;v5](=O)=O)C1=O",1.803,2,0,4]
["E0832","Compound 10w","g8","L3000-46","in 10mM DMSO","Others","Metabolism","Compound 10w, a substituted pyrazolo [1,5-a] pyrimidine amide derivative, shows good anticancer activity against HeLa cell line, with IC50 of less than 10 µM against HeLa cell.",462.45,"1336890-05-1",{"v":46,"d":"46.00"},99.47,"<1","N/A","http://www.selleckchem.com/products/compound-10w.html","C20H24F2N8O3","free base","N/A","COC1=C2N=C(C(F)F)[N](C3=NC(=NC(=N3)N4CCOCC4)N5CCOCC5)C2=CC(=C1)N",2.603,7,1,5]
["E0944","IMD-0560","h8","L3000-46","in 10mM DMSO","IκB/IKK","NF-κB","IMD-0560 is an Inhibitor of nuclear factor kappa-B kinase (IKK) which can suppress the production of inflammatory cytokines and chemokines.",428.12,"439144-66-8",{"v":86,"d":"86.00"},200.88,"<1","N/A","http://www.selleckchem.com/products/imd-0560.html","C15H8BrF6NO2","free base","N/A","OC1=CC=C(Br)C=C1C(=O)NC2=CC(=CC=C2C(F)(F)F)C(F)(F)F",5.005,1,2,4]
["E0945","BIA","a9","L3000-46","in 10mM DMSO","Akt,Calcium Channel","Transmembrane Transporters","BIA (TMBIM6 antagonist BIA), a potential TMBIM6 antagonist, is an inhibitor of the interaction between TMBIM6 (Transmembrane B cell lymphoma 2-associated X protein (BAX) inhibitor motif-containing 6) and mTORC2, which ultimately blocks AKT activation and cancer progression.",268.27,"134271-74-2",{"v":54,"d":"54.00"},201.29,"<1","N/A","http://www.selleckchem.com/products/bia.html","C15H12N2O3","free base","TMBIM6 antagonist BIA","NC1=CC=CC=C1C(=O)\\C=C\\C2=CC=CC(=C2)[N+]([O-])=O",2.849,1,1,4]
["E0956","MP07-66","b9","L3000-46","in 10mM DMSO","phosphatase","PI3K/Akt/mTOR","MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation.",323.47,"1938056-90-6","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/mp07-66.html","C19H33NO3","free base","N/A","CCCCCCOC1=CC=C(CNCC(OCC)OCC)C=C1",4.227,3,1,14]
["E1014","Upamostat (WX-671)","c9","L3000-46","in 10mM DMSO","Serine Protease","Proteases","Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.",629.81,"590368-25-5",{"v":100,"d":"100.00"},158.78,"<1","N/A","http://www.selleckchem.com/products/upamostat-wx-671.html","C32H47N5O6S","free base","WX-671","CCOC(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=N)NO)N[S](=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C",4.907,5,2,13]
["E1061","TRULI","d9","L3000-46","in 10mM DMSO","LATS","Hippo","TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.",{"v":334.4,"d":"334.40"},"1424635-83-5",{"v":67,"d":"67.00"},200.36,"<1","N/A","http://www.selleckchem.com/products/turi.html","C18H14N4OS","free base","N/A","O=C(N=C1SC=CN1CC2=CC=CC=C2)C3=C[NH]C4=NC=CC=C34",2.636,3,1,3]
["E1063","Piperazine Erastin","e9","L3000-46","in 10mM DMSO","Ferroptosis","Apoptosis","Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.",645.19,"1538593-71-3",{"v":100,"d":"100.00"},154.99,"<1","N/A","http://www.selleckchem.com/products/piperazine-erastin.html","C35H41ClN6O4","free base","N/A","CC(C)OC1=CC=C(CN2CCNCC2)C=C1N3C(=NC4=C(C=CC=C4)C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(Cl)C=C6",4.203,5,1,10]
["E1065","SBP-3264","f9","L3000-46","in 10mM DMSO","Serine/threonin kinase","Metabolism","SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in acute myeloid leukemia (AML).",369.85,"N/A",{"v":74,"d":"74.00"},200.08,"<1","N/A","http://www.selleckchem.com/products/sbp-3264.html","N/A","free base","N/A","CC(=O)NC1CCN(CC1)C2=C3C(=NC=N2)[NH]C=C3C4=CC(=CC=C4)Cl",2.592,3,2,3]
["E1081","MiTMAB","g9","L3000-46","in 10mM DMSO","Dynamin","Cytoskeletal Signaling","MiTMAB is a selective dynamin inhibitor that targets the dynamin-phospholipid interaction. MiTMAB inhibits dynamin GTPase activity with a Ki of 940 nM.",336.39,"2253617-91-1",{"v":67,"d":"67.00"},199.17,{"v":67,"d":"67.00"},199.17,"http://www.selleckchem.com/products/mitmab.html","C17H38N.Br","free base","N/A","[Br-].CCCCCCCCCCCCCC[N+](C)(C)C",2.438,0,0,13]
["E1087","5-amino-2,4-dimethylpyridine (5A-DMP)","h9","L3000-46","in 10mM DMSO","E3 Ligase","Ubiquitin","5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts.",122.17,"1193-71-1",{"v":24,"d":"24.00"},196.45,{"v":24,"d":"24.00"},196.45,"http://www.selleckchem.com/products/5-amino-2-4-dimethylpyridine-5a-dmp.html","C7H10N2","free base","N/A","CC1=NC=C(N)C(=C1)C",0.701,1,1,0]
["E1095","ODM-207","a10","L3000-46","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.",375.42,"1801503-93-4",{"v":38,"d":"38.00"},101.22,"<1","N/A","http://www.selleckchem.com/products/odm-207.html","C22H21N3O3","free base","N/A","COC1=C(C=C2C=C(C)C(=O)N(CC3=CC=CC=N3)C2=C1)C4=C(C)ON=C4C",2.937,5,0,4]
["E1107","CTB","b10","L3000-46","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","CTB is a p300 activator and the lowest docked energy for CTB and p300 is 7.72 kcal/mol.",343.73,"451491-47-7",{"v":69,"d":"69.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/ctb.html","C16H13ClF3NO2","free base","N/A","CCOC1=CC=CC=C1C(=O)NC2=CC=C(Cl)C(=C2)C(F)(F)F",4.553,2,1,5]
["E1123","K145","c10","L3000-46","in 10mM DMSO","S1P Receptor","GPCR & G Protein","K145 is a selective, substrate-competitive and orally active sphingosine kinase-2 (SphK2) inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM in biochemical assays.",348.46,"1309444-75-4",{"v":70,"d":"70.00"},200.88,{"v":2,"d":"2.00"},5.74,"http://www.selleckchem.com/products/k145.html","C18H24N2O3S","free base","N/A","CCCCOC1=CC=C(CC\\C=C2/SC(=O)N(CCN)C2=O)C=C1",3.543,3,1,9]
["E1132","CHR-6494","d10","L3000-46","in 10mM DMSO","Haspin Kinase","Cell Cycle","CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM, inhibits histone H3T3 phosphorylation, and can be used in the research of cancer.",292.34,"1333377-65-3",{"v":58,"d":"58.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://www.selleckchem.com/products/chr-6494.html","C16H16N6","free base","N/A","CCCNC1=N[N]2C(=NC=C2C3=CC4=C([NH]N=C4)C=C3)C=C1",2.914,3,2,4]
["E1136","SKLB-197","e10","L3000-46","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.",{"v":424.5,"d":"424.50"},"2713577-16-1",{"v":85,"d":"85.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/sklb-197.html","C25H24N6O","free base","N/A","CC1COCCN1C2=NC(=NC3=C2C=C(C=C3)C4=CC=N[N]4C)C5=C6C=C[NH]C6=CC=C5",4.527,4,1,3]
["E1142","GSK2033","f10","L3000-46","in 10mM DMSO","Liver X Receptor","Metabolism","GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα and LXRβ, respectively.",591.66,"1221277-90-2",{"v":25,"d":"25.00"},42.25,"<1","N/A","http://www.selleckchem.com/products/gsk2033.html","C29H28F3NO5S2","free base","N/A","CC1=CC(=C(C(=C1)C)[S](=O)(=O)N(CC2=CC=C(O2)C(F)(F)F)CC3=CC=C(C=C3)C4=CC(=CC=C4)[S](C)(=O)=O)C",7.032,5,0,9]
["E1146","CHD1Li 6.11","g10","L3000-46","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","CHD1Li 6.11, a potent oncogenic chromodomain helicase DNA binding protein 1 like (CHD1L) inhibitor and an orally bioavailable antitumor agent, shows the enzymatic inhibition of the catalytic CHD1L (cat-CHD1L) recombinant protein with IC50 of 3.3 µM, and significantly reduces the tumor volume of colorectal cancer (CRC) xenografts generated from isolated quasi mesenchymal cells (M-Phenotype).",{"v":472.4,"d":"472.40"},"2716890-91-2",{"v":94,"d":"94.00"},198.98,"<1","N/A","http://www.selleckchem.com/products/chd1li-6-11.html","C21H22BrN5OS","free base","N/A","CC1=CC(=NC(=N1)N2CCCC2)NC3=CC=C(NC(=O)CC4=CC(=CS4)Br)C=C3",5.088,3,2,6]
["E1150","SIRT7 inhibitor 97491","h10","L3000-46","in 10mM DMSO","Sirtuin","Epigenetics","SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.",285.73,"1807758-81-1",{"v":57,"d":"57.00"},199.49,"<1","N/A","http://www.selleckchem.com/products/sirt7-inhibitor-97491.html","C15H12ClN3O","free base","N/A","NC1=CC=CC(=C1)NC2=NC=C(O2)C3=CC=C(Cl)C=C3",3.546,2,2,3]
["E1151","JR-AB2-011","a11","L3000-46","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","JR-AB2-011 is a potent inhibitor of mTOR-mLST8-mSIN1-Rictor complex (mTORC2) which can block mTORC2 signaling and Rictor association with mTOR at lower effective concentrations.",398.28,"2411853-34-2",{"v":80,"d":"80.00"},200.86,"<1","N/A","http://www.selleckchem.com/products/jr-ab2-011.html","C17H14Cl2FN3OS","free base","N/A","CC1CN(C(=O)NC2=CC(=C(Cl)C=C2)Cl)C(S1)=NC3=CC=C(F)C=C3",5.705,2,1,2]
["E1152","AGX51","b11","L3000-46","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization.",431.52,"330834-54-3","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/agx51.html","C27H29NO4","free base","N/A","CCC(=O)N(CCC(C1=CC2=C(OCO2)C=C1)C3=C(OC)C=CC=C3)CC4=CC=CC=C4",5.226,4,0,9]
["E1153","LMT-28","c11","L3000-46","in 10mM DMSO","Interleukins","Immunology & Inflammation","LMT-28 is a novel synthetic interleukin-6 (IL-6) inhibitor that functions through direct binding to gp130.",311.42,"1239600-18-0","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/lmt-28.html","C17H29NO4","free base","N/A","CCCCCC(=C)C(O)C(C)C(=O)N1C(COC1=O)C(C)C",4.001,3,1,8]
["E1158","CAY10444","d11","L3000-46","in 10mM DMSO","S1P Receptor","GPCR & G Protein","CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist, which can inhibit S1P response of S1P3 cell line with 78% inhibition rate and IC50 of 4.6 μM.",287.46,"298186-80-8",{"v":29,"d":"29.00"},100.88,"<1","N/A","http://www.selleckchem.com/products/cay10444.html","C15H29NO2S","free base","BML-241","CCCCCCCCCCCC1NC(CS1)C(O)=O",2.048,1,1,11]
["E1166","tetrathiomolybdate","e11","L3000-46","in 10mM DMSO","ATPase","Transmembrane Transporters","Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson’s disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.",{"v":224.2,"d":"224.20"},"16330-92-0",{"v":45,"d":"45.00"},200.71,"<1","N/A","http://www.selleckchem.com/products/tetrathiomolybdate.html","MoS4","free base","N/A","S=[Mo--;v8](=S)(=S)=S",3.503,0,0,0]
["E1170","R162","f11","L3000-46","in 10mM DMSO","Dehydrogenase","Metabolism","R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.",264.28,"64302-87-0",{"v":7,"d":"7.00"},26.49,"<1","N/A","http://www.selleckchem.com/products/r162.html","C17H12O3","free base","N/A","OC1=C(CC=C)C=CC2=C1C(=O)C3=CC=CC=C3C2=O",3.574,2,1,2]
["E1178","FHD-286","g11","L3000-46","in 10mM DMSO","ATPase","Transmembrane Transporters","FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.",562.66,"2671128-05-3",{"v":100,"d":"100.00"},177.73,"<1","N/A","http://www.selleckchem.com/products/fhd-286.html","C24H30N6O6S2","free base","N/A","COCC(NC(=O)C1=C[N](C=C1)[S;v6](C)(=O)=O)C(=O)NC2=NC(=CS2)C3=CC=CC(=N3)N4CC(C)OC(C)C4",1.919,8,2,9]
["E1189","TES-1025","h11","L3000-46","in 10mM DMSO","Decarboxylase","Metabolism","TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.",383.45,"1883602-21-8",{"v":38,"d":"38.00"},{"v":99.1,"d":"99.10"},"<1","N/A","http://www.selleckchem.com/products/tes-1025.html","C18H13N3O3S2","free base","N/A","OC(=O)CC1=CC=CC(=C1)CSC2=NC(=O)C(=C(N2)C3=CC=CS3)C#N",3.243,3,1,6]
["E1190","UC2288","a2","L3000-47","in 10mM DMSO","p21","Cell Cycle","UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.",481.82,"1394011-91-6",{"v":96,"d":"96.00"},199.24,"<1","N/A","http://www.selleckchem.com/products/uc2288.html","C20H18ClF6N3O2","free base","N/A","FC(F)(F)C1=CC=C(OC2CCC(CC2)NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)N=C1",5.676,3,2,6]
["E1281","Dimethyl itaconate","b2","L3000-47","in 10mM DMSO","NLRP3,Nrf2","Immunology & Inflammation","Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.",158.15,"617-52-7",{"v":32,"d":"32.00"},202.34,{"v":32,"d":"32.00"},202.34,"http://www.selleckchem.com/products/dimethyl-itaconate.html","C7H10O4","free base","N/A","COC(=O)CC(=C)C(=O)OC",0.569,4,0,5]
["E2037","Kisspeptin-10 (human)","c2","L3000-47","in 10mM DMSO","GPR","GPCR & G Protein","Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis, acts as a tumor metastasis suppressor via its receptor GPR54, inducing osteoblast differentiation via NFATc4-mediated BMP2 expression.",1302.44,"374675-21-5",{"v":100,"d":"100.00"},76.78,{"v":25,"d":"25.00"},19.19,"http://www.selleckchem.com/products/kisspeptin-10.html","C63H83N17O14","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CC(N)=O)NC(=O)C(N)CC4=CC=C(O)C=C4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC5=CC=CC=C5)C(N)=O",-2.442,12,18,39]
["E2147","AZD-9574","d2","L3000-47","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AZD-9574 is a novel PARP inhibitor which combines PARP1 selectivity, trapping and high CNS penetration in a single molecule.",428.44,"2756333-39-6",{"v":86,"d":"86.00"},200.73,"<1","N/A","http://www.selleckchem.com/products/azd-9574.html","C21H22F2N6O2","free base","N/A","CNC(=O)C1=NC(=C(C=C1)N2CCN(CC2)CC3=CC=C4N=C(C)C(=O)NC4=C3F)F",1.815,4,2,4]
["E2203","DMU-212","e2","L3000-47","in 10mM DMSO","ERK","MAPK","DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein.",300.35,"134029-62-2",{"v":30,"d":"30.00"},99.88,"<1","N/A","http://www.selleckchem.com/products/dmu-212.html","C18H20O4","free base","N/A","COC1=CC=C(C=C1)/C=C/C2=CC(=C(OC)C(=C2)OC)OC",{"v":3.75,"d":"3.750"},4,0,6]
["E2354","Valepotriate","f2","L3000-47","in 10mM DMSO","Bcl-2,Caspase,Decarboxylase,GABA Receptor","Transmembrane Transporters","Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.",422.47,"18296-44-1","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/valepotriate.html","C22H30O8","free base","N/A","CC(C)CC(=O)OC1OC=C(COC(C)=O)C2=CC(OC(=O)CC(C)C)C3(CO3)C12",2.193,8,0,11]
["E2365","Glutaminase C-IN-1","g2","L3000-47","in 10mM DMSO","Glutaminase","Proteases","Glutaminase C-IN-1 is an allosteric inhibitor of Glutaminase C (GAC) that inhibits cancer cell growth without affecting their normal cellular counterparts.",475.42,"311795-38-7",{"v":48,"d":"48.00"},100.96,"<1","N/A","http://www.selleckchem.com/products/glutaminase-c-in-1.html","C27H27BrN2O","free base","N/A","CN(C)C1=C(Br)C=C(C=C1)C2NC3=C(C4=C2C(=O)CC(C)(C)C4)C5=CC=CC=C5C=C3",6.181,1,1,2]
["E2373","CAN508","h2","L3000-47","in 10mM DMSO","CDK","Cell Cycle","CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM, exhibits a 38-fold selectivity for CDK9/cyclin T1 over other CDK/cyclin complexes.",218.22,"140651-18-9",{"v":44,"d":"44.00"},201.63,"<1","N/A","http://www.selleckchem.com/products/can508.html","C9H10N6O","free base","N/A","NC1=C(N=NC2=CC=C(O)C=C2)C(=N[NH]1)N",1.571,3,4,2]
["E2374","PI-273","a3","L3000-47","in 10mM DMSO","Apoptosis related,PI4K","PI3K/Akt/mTOR","PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.",{"v":381.9,"d":"381.90"},"925069-34-7",{"v":6,"d":"6.00"},15.71,"<1","N/A","http://www.selleckchem.com/products/pi-273.html","C16H16ClN3O2S2","free base","N/A","CCC1=C(C)SC(=C1C(N)=O)NC(=S)NC(=O)C2=CC=C(Cl)C=C2",4.307,2,3,6]
["E2376","KY-05009","b3","L3000-47","in 10mM DMSO","MAP4K,Wnt/beta-catenin","Hippo","KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM, which inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells.",352.41,"1228280-29-2",{"v":70,"d":"70.00"},198.63,"<1","N/A","http://www.selleckchem.com/products/ky-05009.html","C18H16N4O2S","free base","N/A","CC1=CC=C(C=C1)C(=O)NC2=C(N=C(NC3=CC=CC=C3)S2)C(N)=O",3.203,3,3,5]
["E2388","PKR-IN-2","c3","L3000-47","in 10mM DMSO","PKR","ER stress & UPR","PKR-IN-2 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160, which can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.",468.57,"1628428-01-2",{"v":94,"d":"94.00"},200.61,"<1","N/A","http://www.selleckchem.com/products/pkr-in-2.html","C24H28N4O4S","free base","N/A","CC(C)CC1(O)CCN(CC1)C(=O)C2=CC=C(N[S;v6](=O)(=O)C3=CC=CC4=C3N=CC=N4)C=C2",2.065,5,1,6]
["E2393","JNJ-10198409","d3","L3000-47","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.",325.34,"627518-40-5",{"v":65,"d":"65.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/jnj-10198409.html","C18H16FN3O2","free base","N/A","COC1=CC2=C(C=C1OC)C3=C(C2)C(=N[NH]3)NC4=CC=CC(=C4)F",{"v":4.49,"d":"4.490"},3,2,4]
["E2400","1A-116","e3","L3000-47","in 10mM DMSO","Rho","Cell Cycle","1A-116 is a Rac1 inhibitor, with antitumoral and antimetastatic effects in several types of cancer, such as breast cancer, prevents Rac1-regulated processes involved in the primary tumorigenesis and metastastic processes.",307.31,"1430208-73-3",{"v":61,"d":"61.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://www.selleckchem.com/products/1a-116.html","C16H16F3N3","free base","N/A","CC1=CC(=CC(=C1)NC(=N)NC2=C(C=CC=C2)C(F)(F)F)C",4.492,0,2,5]
["E2402","T-1101 tosylate","f3","L3000-47","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity.",665.81,"2250404-95-4",{"v":100,"d":"100.00"},150.19,"<1","N/A","http://www.selleckchem.com/products/t-1101-tosylate.html","C24H23N5O3S2.C7H8O3S","tosylate","TAI-95 tosylate","COCCOC1=CN=C(SC2=CC(=C(C(=C2)C)C3=CSC(=N3)NC(=O)C4=CC=NC=C4)C)C=N1.CC5=CC=C(C=C5)[S](O)(=O)=O",6.511,7,1,10]
["E2511","ZINC05007751","g3","L3000-47","in 10mM DMSO","Others","Cell Cycle","ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line.",{"v":304.3,"d":"304.30"},"591239-68-8",{"v":61,"d":"61.00"},200.46,"<1","N/A","http://www.selleckchem.com/products/zinc05007751.html","C18H12N2O3","free base","N/A","CC\\1=C(C#N)C(=O)NC(=O)C1=C\\C2=CC=C(O2)C3=CC=CC=C3",3.042,3,1,2]
["E2516","Doxorubicin","h3","L3000-47","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM.",543.52,"23214-92-8",{"v":100,"d":"100.00"},183.99,{"v":50,"d":"50.00"},91.99,"http://www.selleckchem.com/products/doxorubicin.html","C27H29NO11","free base","Adriamycin,Hydroxydaunorubicin","COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",-0.044,6,5,5]
["E2548","N-(p-Coumaroyl) Serotonin","a4","L3000-47","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","N-(p-Coumaroyl) Serotonin (p-coumaroylserotonin) is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties, can inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca2+ release from sarcoplasmic reticulum.",322.36,"68573-24-0",{"v":64,"d":"64.00"},198.54,"<1","N/A","http://www.selleckchem.com/products/n--p-coumaroyl--serotonin.html","C19H18N2O3","free base","p-coumaroylserotonin","NA","NA","NA","NA","NA"]
["E2631","Colcemid","b4","L3000-47","in 10mM DMSO","Apoptosis related","Apoptosis","Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor which can incuces cell apoptosis and can be used for cancer research.",371.43,"477-30-5",{"v":75,"d":"75.00"},201.92,{"v":75,"d":"75.00"},201.92,"http://www.selleckchem.com/products/colcemid.html","C21H25NO5","free base","Demecolcine","CNC1CCC2=CC(=C(OC)C(=C2C3=CC=C(OC)C(=O)C=C13)OC)OC",2.454,5,1,5]
["E2632","Norharmane","c4","L3000-47","in 10mM DMSO","MAO","Neuronal Signaling","Norharmane (Norharman) is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM.",168.19,"244-63-3",{"v":34,"d":"34.00"},202.15,"<1","N/A","http://www.selleckchem.com/products/norharmane.html","C11H8N2","free base","Norharman, β-Carboline","[NH]1C2=C(C=CC=C2)C3=C1C=NC=C3",2.172,1,1,0]
["E2633","Tris(2-chloroethyl) phosphate","d4","L3000-47","in 10mM DMSO","Others","Others","Tris(2-chloroethyl) phosphate is served as flame retardants.",285.49,"115-96-8","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/tris-2-chloroethyl--phosphate.html","C6H12Cl3O4P","free base","N/A","ClCCO[P](=O)(OCCCl)OCCCl",1.644,3,0,9]
["E2641","trans-Chalcone","e4","L3000-47","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.",208.26,"614-47-1",{"v":42,"d":"42.00"},201.67,"<1","N/A","http://www.selleckchem.com/products/trans-chalcone.html","C15H12O","free base","N/A","O=C(\\C=C\\C1=CC=CC=C1)C2=CC=CC=C2",3.701,1,0,3]
["E2642","CGP60474","f4","L3000-47","in 10mM DMSO","CDK","Cell Cycle","CGP60474, a highly potent anti-endotoxemic  agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively).",355.82,"164658-13-3",{"v":71,"d":"71.00"},199.54,"<1","N/A","http://www.selleckchem.com/products/cgp60474.html","C18H18ClN5O","free base","N/A","OCCCNC1=NC=CC(=C1)C2=NC(=NC=C2)NC3=CC=CC(=C3)Cl",3.453,3,3,7]
["E2659","DMAT","g4","L3000-47","in 10mM DMSO","Casein Kinase","Metabolism","DMAT is a high affinity and selective casein kinase-2 (CK2) inhibitor with IC50 of ~0.14 μM and Ki of ~40 nM.",476.79,"749234-11-5",{"v":95,"d":"95.00"},199.25,"<1","N/A","http://www.selleckchem.com/products/dmat.html","C9H7Br4N3","free base","N/A","CN(C)C1=NC2=C(Br)C(=C(Br)C(=C2[NH]1)Br)Br",5.042,1,1,1]
["E2663","BT2","h4","L3000-47","in 10mM DMSO","Bcl-2","Apoptosis","BT2 is a novel branched-chain α-ketoacid dehydrogenase complex kinase (BDK) inhibitor wieh an IC50 of 3.19 μM.",{"v":247.1,"d":"247.10"},"34576-94-8",{"v":49,"d":"49.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://www.selleckchem.com/products/bt2.html","C9H4Cl2O2S","free base","N/A","OC(=O)C1=C(Cl)C2=CC=C(Cl)C=C2S1",3.941,1,0,1]
["E2664","Cridanimod","a5","L3000-47","in 10mM DMSO","STING","Immunology & Inflammation","Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).",253.25,"38609-97-1",{"v":51,"d":"51.00"},201.38,"<1","N/A","http://www.selleckchem.com/products/cridanimod.html","C15H11NO3","free base","N/A","OC(=O)CN1C2=CC=CC=C2C(=O)C3=C1C=CC=C3",2.641,2,0,2]
["E2682","RPI-1","b5","L3000-47","in 10mM DMSO","Akt,JNK","MAPK","RPI-1 inhibits proliferation of human papillary thyroid carcinoma cell line TPC-1 by inducing accumulation of cells at the G2 cell cycle phase, abolishes Ret/Ptc1 tyrosine phosphorylation along with its binding to Shc and phospholipase Cg, also abolishes the activation of JNK2 and AKT.",297.31,"269730-03-2",{"v":59,"d":"59.00"},198.45,"<1","N/A","http://www.selleckchem.com/products/rpi-1.html","C17H15NO4","free base","N/A","COC1=C(OC)C=C/2C(=C1)NC(=O)C2=C/C3=CC=C(O)C=C3",2.456,3,2,3]
["E2684","Icilin","c5","L3000-47","in 10mM DMSO","TRP Channel","Neuronal Signaling","Icilin is an agonist of the transient receptor potential M8 (TRPM8) ion channel with an EC50 of 1.4 μM.",311.29,"36945-98-9",{"v":62,"d":"62.00"},199.17,"<1","N/A","http://www.selleckchem.com/products/icilin.html","C16H13N3O4","free base","N/A","OC1=C(C=CC=C1)N2CC=C(NC2=O)C3=CC(=CC=C3)[N;v5](=O)=O",2.306,1,2,3]
["E2697","TCPP","d5","L3000-47","in 10mM DMSO","Others","Others","TCPP (Tris(2-chloroethyl) phosphate) is a pervasive flame retardant.",327.57,"13674-84-5","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/tcpp.html","C9H18Cl3O4P","free base","Tris (clorisopropyl)phosphate","CC(CCl)O[P;v5](=O)(OC(C)CCl)OC(C)CCl",2.776,3,0,9]
["E2699","Tris(2-butoxyethyl) phosphate","e5","L3000-47","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Oral exposure to low-dose Tris (2-butoxyethyl) phosphate (TBEP) levels equivalent to tolerable daily intake may exacerbate allergic pulmonary inflammation by promoting a skewed T-helper 2 cell response, upregulation of ERα and dysregulation of both MLN and BM microenvironments.",398.47,"78-51-3","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/tris-2-butoxyethyl-phosphate.html","C18H39O7P","free base","TBEP","CCCCOCCO[P;v5](=O)(OCCOCCCC)OCCOCCCC",3.242,6,0,21]
["E2826","Hematein","f5","L3000-47","in 10mM DMSO","Akt,Casein Kinase","Metabolism","Hematein inhibits casein kinase II activity in a selective, dose-dependent and ATP non-competitive manner in vitro, with IC50 of 0.55 μM in the presence of 10 μM ATP.",300.26,"475-25-2",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://www.selleckchem.com/products/hematein.html","C16H12O6","free base","N/A","OC1=CC2=C(C=C1O)C3=C4C=CC(=O)C(=C4OCC3(O)C2)O",0.558,2,3,0]
["E2829","Alkannin","g5","L3000-47","in 10mM DMSO","PKM","Metabolism","Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).",289.37,"517-88-4",{"v":100,"d":"100.00"},345.58,"<1","N/A","http://www.selleckchem.com/products/alkannin.html","C16H16O5","free base","N/A","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["E2832","LCS-1","h5","L3000-47","in 10mM DMSO","SOD","Metabolism","LCS-1 is an inhibitor of superoxide dismutase 1(SOD1) with IC50 of 1.07 μM.",{"v":255.1,"d":"255.10"},"41931-13-9",{"v":51,"d":"51.00"},199.92,"<1","N/A","http://www.selleckchem.com/products/lcs-1.html","C11H8Cl2N2O","free base","N/A","CC1=CC(=CC=C1)N2N=CC(=C(Cl)C2=O)Cl",2.701,2,0,1]
["E2833","1,5-Anhydro-D-glucitol","a6","L3000-47","in 10mM DMSO","Others","Others","1,5-Anhydro-D-glucitol (1,5-Anhydroglucitol, 1,5-AG) is a naturally occurring monosaccharide found in nearly all foods, supporting reliable evidences for early forecast and screening of diabetes mellitus.",164.16,"154-58-5",{"v":33,"d":"33.00"},201.02,{"v":33,"d":"33.00"},201.02,"http://www.selleckchem.com/products/1-5-anhydro-d-glucitol.html","C6H12O5","free base","N/A","OCC1OCC(O)C(O)C1O",-2.174,1,4,1]
["E2847","TPPU","b6","L3000-47","in 10mM DMSO","Epoxide Hydrolase","Metabolism","TPPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 37 and 3.7 nM for monkey and human sEH, respectively.",359.34,"1222780-33-7",{"v":72,"d":"72.00"},200.37,"<1","N/A","http://www.selleckchem.com/products/tppu.html","C16H20F3N3O3","free base","N/A","CCC(=O)N1CCC(CC1)NC(=O)NC2=CC=C(OC(F)(F)F)C=C2",3.103,3,2,5]
["P1107","Alamandine","c6","L3000-47","in 10mM DMSO","Ras","MAPK","Alamandine is a component of the renin-angiotensin system, which regulates blood pressure.",{"v":855,"d":"855.00"},"1176306-10-7",{"v":50,"d":"50.00"},58.48,{"v":50,"d":"50.00"},58.48,"http://www.selleckchem.com/products/alamandine.html","C40H62N12O9","free base","N/A","CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(C)N)C(C)C)C(=O)NC(CC2=C[NH]C=N2)C(=O)N3CCCC3C(O)=O",-3.207,8,10,24]
["P1110","Etelcalcetide HCl","d6","L3000-47","in 10mM DMSO","CaSR","GPCR & G Protein","Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.",1084.71,"1334237-71-6",{"v":100,"d":"100.00"},92.19,{"v":100,"d":"100.00"},92.19,"http://www.selleckchem.com/products/etelcalcetide-hcl.html","C38H74ClN21O10S2","hydrochloride","AMG 416","Cl.CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(S)C(N)(S)C(O)=O)NC(C)=O)C(=O)NC(CCCN=C(N)N)C(N)=O",-9.149,13,17,34]
["P1116","Epitalon","e6","L3000-47","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Epitalon is an anti-aging agent and a telomerase activator, with an inhibitory effect of the on the development of spontaneous tumors in mice, as well as geroprotective actions and intranasal administration increases neuronal activity, also can be used for cancer, old age and Retinitis Pigmentosa.",390.35,"307297-39-8",{"v":78,"d":"78.00"},199.82,{"v":78,"d":"78.00"},199.82,"http://www.selleckchem.com/products/epitalon.html","C14H22N4O9","free base","Epithalon","CC(N)C(=O)NC(CCC(O)=O)C(=O)NC(CC(O)=O)C(=O)NCC(O)=O",{"v":-5.93,"d":"-5.930"},6,4,12]
["P1134","diprotin A","f6","L3000-47","in 10mM DMSO","DPP","Proteases","Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).",341.45,"90614-48-5",{"v":68,"d":"68.00"},199.15,{"v":68,"d":"68.00"},199.15,"http://www.selleckchem.com/products/diprotin-a.html","C17H31N3O4","Diacetate","Ile-Pro-Ile","CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(O)=O",-1.157,3,2,8]
["P1136","HIV Peptide T","g6","L3000-47","in 10mM DMSO","gp120/CD4","Immunology & Inflammation","HIV Peptide T (Peptide T), a synthetic octapeptide and an antiviral agent for use in HIV infection, of which mechanism of action consists of competitive inhibition of the binding of gp120 (a surface protein of HIV) to the CD4 receptor, homologous binding to vasointestinal peptide (VIP) receptors, and blockade of cytokine production and function.",857.86,"106362-33-8",{"v":100,"d":"100.00"},116.57,{"v":100,"d":"100.00"},116.57,"http://www.selleckchem.com/products/hiv-peptide-t.html","C35H55N9O16","Diacetate","Peptide T","CC(N)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(C(C)O)C(O)=O",-9.217,9,15,24]
["P1152","Oglufanide","h6","L3000-47","in 10mM DMSO","Antiviral,Bacterial,VEGFR","Protein Tyrosine Kinase","Oglufanide (H-Glu-Trp-OH, L-Glutamyl-L-tryptophan), a dipeptide immunomodulator isolated from calf thymus, inhibits vascular endothelial growth factor (VEGF), also stimulates the immune response to hepatitic C virus (HCV) and intracellular bacterial infections.",333.34,"38101-59-6",{"v":34,"d":"34.00"},{"v":102,"d":"102.00"},"<1","N/A","http://www.selleckchem.com/products/qglufanide.html","C16H19N3O5","free base","H-Glu-Trp-OH, L-Glutamyl-L-tryptophan","NC(CCC(O)=O)C(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(O)=O",-2.066,3,3,8]
["P1153","PKG inhibitor peptide","a7","L3000-47","in 10mM DMSO","PKG","GPCR & G Protein","PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.",943.11,"82801-73-8",{"v":100,"d":"100.00"},106.03,{"v":100,"d":"100.00"},106.03,"http://www.selleckchem.com/products/pkg-inhibitor-peptide.html","C38H74N18O10","free base","N/A","CC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(O)=O)C(O)=O",-10.841,8,15,39]
["P1161","Angstrom6","b7","L3000-47","in 10mM DMSO","CD markers","Immunology & Inflammation","Angstrom6 (A6 Peptide) is a capped, eight l-amino acid peptide (Ac-KPSSPPEE-NH2) derived from the biologically active connecting peptide domain of the serine protease, human urokinase plasminogen activator (uPA), which can binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.",910.97,"220334-14-5",{"v":100,"d":"100.00"},109.77,{"v":100,"d":"100.00"},109.77,"http://www.selleckchem.com/products/angstrom6.html","C39H62N10O15","free base","A6 Peptide","CC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CO)C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(N)=O",-8.457,11,9,25]
["P1216","Box5","c7","L3000-47","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.",666.76,"881188-48-3",{"v":100,"d":"100.00"},149.98,{"v":2,"d":"2.00"},{"v":3,"d":"3.00"},"http://www.selleckchem.com/products/box5.html","C25H42N6O11S2","free base","N/A","CSCCC(N)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CS)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(O)=O",{"v":-5.2,"d":"-5.200"},8,6,22]
["P1236","CYN154806","d7","L3000-47","in 10mM DMSO","SSTR","Endocrinology & Hormones","CYN154806, a cyclic octapeptide, is a potent and selective somatostatin SST2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant SST2, SST1, SST3, SST4 and SST5 receptors respectively.",1197.34,"183658-72-2",{"v":100,"d":"100.00"},83.52,{"v":50,"d":"50.00"},41.76,"http://www.selleckchem.com/products/cyn154806.html","C56H68N12O14S2","free base","N/A","CC(O)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(CC5=CC=C(O)C=C5)C(N)=O)NC(=O)C(CC6=CC=C(C=C6)[N;v5](=O)=O)NC(C)=O",1.182,9,14,20]
["S0947","Cafestol","e7","L3000-47","in 10mM DMSO","Apoptosis related,Immunology & Inflammation related,PI3K,ROS","PI3K/Akt/mTOR","Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.",316.43,"469-83-0",{"v":63,"d":"63.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://www.selleckchem.com/products/cafestol.html","C20H28O3","free base","N/A","CC12CCC3=C(C=CO3)C1CCC45CC(CCC24)C(O)(CO)C5",2.845,1,1,1]
["S0969","Heterophyllin B","f7","L3000-47","in 10mM DMSO","Others","Metabolism","Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla, which provides a novel strategy for the treatment of esophageal cancer.",778.94,"145459-19-4",{"v":100,"d":"100.00"},128.38,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/heterophyllin-b.html","C40H58N8O8","free base","N/A","CCC(C)C1NC(=O)C2CCCN2C(=O)C3CCCN3C(=O)C4CCCN4C(=O)C(CC(C)C)NC(=O)CNC(=O)CNC(=O)C(CC5=CC=CC=C5)NC1=O",0.424,8,5,6]
["S1469","Calcifediol","g7","L3000-47","in 10mM DMSO","Vitamin","Metabolism","Calcifediol (Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).",400.64,"19356-17-3",{"v":80,"d":"80.00"},199.68,"<1","N/A","http://www.selleckchem.com/products/Calcifediol.html","C27H44O2","free base","Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol","CC(CCCC(C)(C)O)C1CCC2/C(CCCC12C)=C/C=C3/CC(O)CCC3=C",6.404,0,1,6]
["S2841","Bemcentinib (R428)","h7","L3000-47","in 10mM DMSO","Axl","Protein Tyrosine Kinase","Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).",506.64,"1037624-75-1",{"v":6,"d":"6.00"},11.84,"<1","N/A","http://www.selleckchem.com/products/r428.html","C30H34N8","free base","BGB324","NC1=NC(=N[N]1C2=NN=C3C(=C2)CCCC4=CC=CC=C34)NC5=CC=C6CCC(CCC6=C5)N7CCCC7",7.035,4,2,4]
["S3290","Procyanidin B2","a8","L3000-47","in 10mM DMSO","NLRP3,PPAR","Metabolism","Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.",578.52,"29106-49-8",{"v":100,"d":"100.00"},172.85,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/procyanidin-b2.html","C30H26O12","free base","PCB2","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C(=C(O)C=C2O)C4C(O)C(OC5=CC(=CC(=C45)O)O)C6=CC(=C(O)C=C6)O",3.565,2,10,3]
["S6918","Oleandrin (PBI-05204)","b8","L3000-47","in 10mM DMSO","ATPase","Transmembrane Transporters","Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) is an inhibitor of Na+/K+-ATPase with IC50 of 0.62 μM. Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro.",576.72,"465-16-7",{"v":100,"d":"100.00"},173.39,"<1","N/A","http://www.selleckchem.com/products/oleandrin-pbi-05204.html","C32H48O9","free base","Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol","COC1CC(OC(C)C1O)OC2CCC3(C)C(CCC4C3CCC5(C)C(C(CC45O)OC(C)=O)C6=CC(=O)OC6)C2",{"v":2.78,"d":"2.780"},7,1,6]
["S7048","Talazoparib (BMN 673)","c8","L3000-47","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Talazoparib (BMN 673, LT-673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.",380.35,"1207456-01-6",{"v":38,"d":"38.00"},99.91,"<1","N/A","http://www.selleckchem.com/products/bmn-673.html","C19H14F2N6O","free base","LT-673","C[N]1N=CN=C1C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(F)C=C5",2.467,4,2,2]
["S7062","Pinometostat (EPZ5676)","d8","L3000-47","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.",562.71,"1380288-87-8",{"v":100,"d":"100.00"},177.71,"<1","N/A","http://www.selleckchem.com/products/epz-5676.html","C30H42N8O3","free base","N/A","CC(C)N(CC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N)C4CC(CCC5=NC6=CC=C(C=C6[NH]5)C(C)(C)C)C4",3.567,5,4,9]
["S7101","SCH772984","e8","L3000-47","in 10mM DMSO","ERK","MAPK","SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay, respectively, And show robust efficacy in RAS- or BRAF-mutant cancer cells.",587.67,"942183-80-4",{"v":14,"d":"14.00"},23.82,"<1","N/A","http://www.selleckchem.com/products/sch772984.html","C33H33N9O2","free base","N/A","O=C(CN1CCC(C1)C(=O)NC2=CC=C3[NH]N=C(C4=CC=NC=C4)C3=C2)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7",2.432,6,2,7]
["S7108","Encorafenib (LGX818)","f8","L3000-47","in 10mM DMSO","Raf","MAPK","Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3.",540.01,"1269440-17-6",{"v":100,"d":"100.00"},185.18,"<1","N/A","http://www.selleckchem.com/products/lgx818.html","C22 H27 Cl F N7 O4 S","free base","N/A","COC(=O)NC(C)CNC1=NC=CC(=N1)C2=C[N](N=C2C3=C(F)C(=CC(=C3)Cl)N[S;v6](C)(=O)=O)C(C)C",3.645,7,3,10]
["S7428","Rocaglamide","g8","L3000-47","in 10mM DMSO","eIF,HSP (HSP90),NF-κB","ER stress & UPR","Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.",505.56,"84573-16-0",{"v":100,"d":"100.00"},{"v":197.8,"d":"197.80"},"<1","N/A","http://www.selleckchem.com/products/rocaglamide.html","C29H31NO7","free base","Roc-A","COC1=CC=C(C=C1)C23OC4=C(C(=CC(=C4)OC)OC)C2(O)C(O)C(C3C5=CC=CC=C5)C(=O)N(C)C",2.737,5,1,6]
["S7580","Leptomycin B","h8","L3000-47","in 10mM DMSO","CRM1","Transmembrane Transporters","Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.",540.73,"87081-35-4",{"v":100,"d":"100.00"},184.94,"<1","N/A","http://www.selleckchem.com/products/leptomycinb.html","C33H48O6","free base","LMB, CI 940, Elactocin,  Mantuamycin, NSC 364372","CCC(/C=C/C1OC(=O)C=CC1C)=C/C(C)C/C=C/C(C)=C/C(C)C(=O)C(C)C(O)C(C)C\\C(C)=C\\C(O)=O",7.507,4,1,15]
["S7817","MI-503","a9","L3000-47","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.",564.63,"1857417-13-0",{"v":100,"d":"100.00"},177.11,"<1","N/A","http://www.selleckchem.com/products/mi-503.html","C28H27F3N8S","free base","N/A","CC1=C2C=C(C#N)[N](CC3=C[NH]N=C3)C2=CC=C1CN4CCC(CC4)NC5=C6C=C(CC(F)(F)F)SC6=NC=N5",5.606,3,2,8]
["S8162","Upadacitinib (ABT-494)","b9","L3000-47","in 10mM DMSO","JAK","JAK/STAT","Upadacitinib (ABT-494) is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM),  with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1.",380.37,"1310726-60-3",{"v":76,"d":"76.00"},199.81,"<1","N/A","http://www.selleckchem.com/products/upadacitinib.html","C17H19F3N6O","free base","N/A","CCC1CN(CC1C2=CN=C3C=NC4=C(C=C[NH]4)[N]23)C(=O)NCC(F)(F)F",1.967,3,2,4]
["S8297","ARV-825","c9","L3000-47","in 10mM DMSO","Epigenetic Reader Domain,PROTAC","Epigenetics","ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC.",923.43,"1818885-28-7",{"v":100,"d":"100.00"},108.29,"<1","N/A","http://www.selleckchem.com/products/arv-825.html","C46H47ClN8O9S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(OCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C7CCC(=O)NC7=O)C6=O)C=C4)N=C2C8=CC=C(Cl)C=C8)C",4.266,12,3,19]
["S8553","Avapritinib (BLU-285)","d9","L3000-47","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).",498.56,"1703793-34-3",{"v":66,"d":"66.00"},132.38,"<1","N/A","http://www.selleckchem.com/products/blu-285.html","C26H27FN10","free base","N/A","C[N]1C=C(C=N1)C2=C[N]3N=CN=C(N4CCN(CC4)C5=NC=C(C=N5)C(C)(N)C6=CC=C(F)C=C6)C3=C2",2.799,5,1,5]
["S8587","Withaferin A","e9","L3000-47","in 10mM DMSO","NF-κB","NF-κB","Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.",{"v":470.6,"d":"470.60"},"5119-48-2",{"v":94,"d":"94.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/withaferin-a.html","C28H38O6","free base","WA, WFA","CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(=O)C6(C)C4CCC23C",3.388,4,2,3]
["S8719","AZD4573","f9","L3000-47","in 10mM DMSO","CDK","Cell Cycle","AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.",429.94,"2057509-72-3",{"v":86,"d":"86.00"},200.03,"<1","N/A","http://www.selleckchem.com/products/azd4573.html","C22H28ClN5O2","free base","N/A","CC(=O)NC1CCCC(C1)C(=O)NC2=CC(=C(Cl)C=N2)C3=C4CC(C)(C)C[N]4N=C3",2.786,4,2,4]
["S8809","MC180295","g9","L3000-47","in 10mM DMSO","CDK","Cell Cycle","MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.",358.41,"2237942-08-2",{"v":72,"d":"72.00"},200.89,"<1","N/A","http://www.selleckchem.com/products/mc180295.html","C17H18N4O3S","free base","(rel)-MC180295","NC1=C(SC(=N1)NC2CC3CCC2C3)C(=O)C4=C(C=CC=C4)[N;v5](=O)=O",{"v":3.62,"d":"3.620"},2,2,5]
["S8833","TAS0728","h9","L3000-47","in 10mM DMSO","HER2","Protein Tyrosine Kinase","TAS0728 (TPC 107) is a potent, selective, orally active, irreversible and covalent-binding inhibitor of HER2 (human epidermal growth factor receptor 2) with IC50 of 13 nM. TAS0728 inihibits BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2 with IC50 of 4.9 nM, 8.5 nM, 31 nM, 65 nM, 33 nM, 25 nM, 86 nM and 36 nM, respectively. TAS0728 shows antitumor activity.",504.58,"2088323-16-2",{"v":100,"d":"100.00"},198.18,"<1","N/A","http://www.selleckchem.com/products/tas0728.html","C26H32N8O3","free base","TPC 107","CN(C)C(=O)CC1=CC=C(NC(=O)C2=N[N](C3CCCN(C3)C(=O)C=C)C4=NC=NC(=C24)N)C(=C1C)C",2.112,6,2,6]
["S8983","MAK683","a10","L3000-47","in 10mM DMSO","Histone Methyltransferase","Epigenetics","MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.",376.39,"1951408-58-4",{"v":20,"d":"20.00"},53.14,"<1","N/A","http://www.selleckchem.com/products/mak683.html","C20H17FN6O","free base","EED inhibitor-1","CC1=C(C=CC=N1)C2=CN=C(NCC3=C(F)C=CC4=C3CCO4)[N]5C=NN=C25",2.824,5,1,4]
["S9014","AstragalosideⅠ","b10","L3000-47","in 10mM DMSO","Others","Others","AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.",869.04,"84680-75-1",{"v":100,"d":"100.00"},115.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/astragaloside-i.html","C45H72O16","free base","N/A","CC(=O)OC1C(O)COC(OC2CCC34CC35CCC6(C)C(C(O)CC6(C)C5CC(OC7OC(CO)C(O)C(O)C7O)C4C2(C)C)C8(C)CCC(O8)C(C)(C)O)C1OC(C)=O",{"v":0.41,"d":"0.410"},9,6,11]
["S9213","Jujuboside A","c10","L3000-47","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis.",1207.35,"55466-04-1",{"v":100,"d":"100.00"},82.83,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/jujuboside-a.html","C58H94O26","free base","N/A","CC1OC(OC2C(OCC(O)C2OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3OC5OCC(O)C(O)C5O)OC6CCC7(C)C(CCC8(C)C7CCC9C%10C(C)(O)CC(OC%10%11CC89CO%11)C=C(C)C)C6(C)C)C(O)C(O)C1O",-2.433,12,13,13]
["S9659","UNC6852","d10","L3000-47","in 10mM DMSO","Epigenetic Reader Domain,Histone Methyltransferase,PROTAC","Epigenetics","UNC6852 is a selective degrader that targets polycomb repressive complex 2 (PRC2) with IC50 of 247 nM for EED. UNC6852 is based on PROTAC and contains an EED226-derived ligand and a ligand for VHL.",832.97,"2688842-08-0",{"v":100,"d":"100.00"},120.05,"<1","N/A","http://www.selleckchem.com/products/unc6852.html","C43H48N10O6S","free base","N/A","CC1=C(SC=N1)C2=CC=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)CCCNC(=O)C4=CC=C(C=C4)C5=CN=C(NCC6=CC=CO6)[N]7C=NN=C57)C(C)(C)C)C=C2",3.011,9,5,16]
["S9690","Caerulein (FI-6934)","e10","L3000-47","in 10mM DMSO","CCK receptor","GPCR & G Protein","Caerulein (Ceruletide, Cerulein, FI-6934), a cholecystokinin (CCK) receptor agonist, is a safe and effective cholecystokinetic agent and small bowel and exocrine pancreatic stimulant.",{"v":1352.4,"d":"1352.40"},"17650-98-5",{"v":100,"d":"100.00"},73.94,"<1","N/A","http://www.selleckchem.com/products/caerulein.html","C58H73N13O21S2","free base","Ceruletide, Cerulein","CSCCC(NC(=O)C(CC1=C[NH]C2=C1C=CC=C2)NC(=O)CNC(=O)C(NC(=O)C(CC3=CC=C(O[S](O)(=O)=O)C=C3)NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C4CCC(=O)N4)C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CC5=CC=CC=C5)C(N)=O",-3.991,15,14,38]
["E0201","Hypaconitine","f10","L3000-47","in 10mM DMSO","Others","TGF-beta/Smad","Hypaconitine (Deoxymesaconitine) is an active diterpene alkaloid derived from Aconitum species. Hypaconitine inhibits TGF-β1-induced epithelial–mesenchymal transition.",615.71,"6900-87-4",{"v":100,"d":"100.00"},162.41,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hypaconitine.html","C33H45NO10","free base","Deoxymesaconitine","COCC12CCC(OC)C34C5CC6(O)C(OC)C(O)C(OC(C)=O)(C5C6OC(=O)C7=CC=CC=C7)C(C(OC)C13)C4N(C)C2",-0.102,8,1,10]
["E0675","Quercetagetin","g10","L3000-47","in 10mM DMSO","Pim","Epigenetics","Quercetagetin (6-Hydroxyquercetin), a flavonoid, is a moderately potent and selective, cell-permeable Pim-1 kinase inhibitor with IC50 of 0.34 μM.",318.24,"90-18-6",{"v":64,"d":"64.00"},201.11,"<1","N/A","http://www.selleckchem.com/products/quercetagetin.html","C15H10O8","free base","6-Hydroxyquercetin","OC1=CC=C(C=C1O)C2=C(O)C(=O)C3=C(O)C(=C(O)C=C3O2)O",1.388,2,6,1]
["E2748","EGCG Octaacetate","h10","L3000-47","in 10mM DMSO","Others","Others","EGCG Octaacetate(AcEGCG) is a pro-drug of epigallocatechin-3-gallate (EGCG). EGCG have potent anti-oxidative, anti-mitotic and anti-angiogenic properties.",794.67,"148707-39-5",{"v":100,"d":"100.00"},125.84,"<1","N/A","http://www.selleckchem.com/products/egcg-octaacetate.html","C38H34O19","free base","AcEGCG","CC(=O)OC1=CC2=C(CC(OC(=O)C3=CC(=C(OC(C)=O)C(=C3)OC(C)=O)OC(C)=O)C(O2)C4=CC(=C(OC(C)=O)C(=C4)OC(C)=O)OC(C)=O)C(=C1)OC(C)=O",3.174,19,0,20]
["S0078","1V209 (TLR7 agonist T7)","a11","L3000-47","in 10mM DMSO","TLR","Immunology & Inflammation","1V209 (T7, TLR7 agonist T7) is an agonist of Toll-like receptor 7 (TLR7) with anti-tumor effects. 1V209 can be used as vaccine adjuvants, enhances antigen specific humoral and cellular immune responses.",359.34,"1062444-54-5",{"v":72,"d":"72.00"},200.37,"<1","N/A","http://www.selleckchem.com/products/1v209-tlr7-agonist-t7.html","C16H17N5O5","Free base","T7","COCCOC1=NC(=C2NC(=O)N(CC3=CC=C(C=C3)C(O)=O)C2=N1)N",1.038,6,2,7]
["S0356","Pulrodemstat (CC-90011) besylate","b11","L3000-47","in 10mM DMSO","Histone Demethylase,LSD1","Methylation","Pulrodemstat (CC-90011) besylate (LSD1-IN-7 benzenesulfonate) is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.",609.64,"2097523-60-7",{"v":100,"d":"100.00"},164.03,"<1","N/A","http://www.selleckchem.com/products/cc-90011.html","C30H29F2N5O5S","Besylate","LSD1-IN-7 benzenesulfonate","COC1=C(F)C=C(C=C1)C2=C(N=C(N(C)C2=O)N3CCC(N)CC3)C4=CC(=C(C=C4)C#N)F.O[S](=O)(=O)C5=CC=CC=C5",3.467,3,1,5]
["S0428","Etalocib","c11","L3000-47","in 10mM DMSO","LTR","GPCR & G Protein","Etalocib(LY293111, VML295) is a leukotriene B4 receptor (LTB4R) antagonist that blocks activation of human neutrophils.",544.61,"161172-51-6",{"v":100,"d":"100.00"},183.62,"<1","N/A","http://www.selleckchem.com/products/ly-293111.html","C33H33FO6","Free base","LY293111, VML295","CCCC1=C(OCCCOC2=C(CC)C=C(C(=C2)O)C3=CC=C(F)C=C3)C=CC=C1OC4=CC=CC=C4C(O)=O",8.521,4,1,13]
["S0504","SU14813","d11","L3000-47","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.",442.48,"627908-92-3",{"v":88,"d":"88.00"},198.88,"<1","N/A","http://www.selleckchem.com/products/su14813.html","C23H27FN4O4","Free base","SU 014813","CC1=C(C(=C([NH]1)\\C=C\\2C(=O)NC3=C2C=C(F)C=C3)C)C(=O)NCC(O)CN4CCOCC4",1.477,3,4,6]
["S0733","Tegatrabetan (BC-2059)","e11","L3000-47","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.",588.74,"1227637-23-1",{"v":100,"d":"100.00"},169.85,{"v":100,"d":"100.00"},169.85,"http://www.selleckchem.com/products/tegatrabetan.html","C28H36N4O6S2","Free base","N/A","CC1CC(C)CN(C1)[S](=O)(=O)C2=CC3=C(C=C2)C(N=O)C4=C(C=C(C=C4)[S](=O)(=O)N5CC(C)CC(C)C5)C3N=O",5.076,6,0,6]
["S0872","ASTX-029","f11","L3000-47","in 10mM DMSO","ERK","MAPK","ASTX-029 is an orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. ASTX-029 inhibits ERK-dependent tumor cell proliferation and survival.",584.04,"2095719-92-7",{"v":100,"d":"100.00"},171.22,"<1","N/A","http://www.selleckchem.com/products/astx-029.html","C29H31ClFN5O5","Free base","N/A","COC1=CC(=CC(=C1)C(CO)NC(=O)C(C)N2CC3=CC=C(C=C3C2=O)C4=NC(=NC=C4Cl)NC5CCOCC5)F",2.806,6,3,9]
["S1217","Cyclophosphamide","g11","L3000-47","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.",261.09,"50-18-0",{"v":52,"d":"52.00"},199.17,{"v":43,"d":"43.00"},164.69,"http://www.selleckchem.com/products/Clafen.html","C7H15Cl2N2O2P","Free base","NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane","ClCCN(CCCl)[P]1(=O)NCCCO1",0.144,2,1,5]
["S1522","Tosedostat (CHR2797)","h11","L3000-47","in 10mM DMSO","Aminopeptidase","Metabolism","Tosedostat (CHR2797) is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively, and does not effectively inhibit either PILSAP, MetAP-2, LTA4 hydrolase, or MetAP-2. Phase 2.",406.47,"238750-77-1",{"v":51,"d":"51.00"},125.47,"<1","N/A","http://www.selleckchem.com/products/CHR-2797(Tosedostat).html","C21H30N2O6","Free base","N/A","CC(C)CC(C(O)C(=O)NO)C(=O)NC(C(=O)OC1CCCC1)C2=CC=CC=C2",2.406,4,3,10]
["S1575","RO4929097","a2","L3000-48","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.",{"v":469.4,"d":"469.40"},"847925-91-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://www.selleckchem.com/products/RO4929097.html","C22H20F5N3O3","Free base","RG-4733","CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)NC1C(=O)NC2=CC=CC=C2C3=C1C=CC=C3",3.184,3,3,6]
["S2221","Apatinib (YN968D1) mesylate","b2","L3000-48","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.",493.58,"1218779-75-9",{"v":22,"d":"22.00"},44.57,"<1","N/A","http://www.selleckchem.com/products/Apatinib-YN968D1.html","C25H27N5O4S","Mesylate","YN968D1, Rivoceranib","C[S](O)(=O)=O.O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=CC=CN=C3NCC4=CC=NC=C4",3.164,3,2,6]
["S2653","9-amino-CPT (9-Aminocamptothecin)","c2","L3000-48","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.",363.37,"91421-43-1",{"v":25,"d":"25.00"},{"v":68.8,"d":"68.80"},"<1","N/A","http://www.selleckchem.com/products/9-amino-cpt.html","C20H17N3O4","Free base","9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=C(N)C5=C4)C2=O",0.999,4,1,1]
["S2733","AV-412 free base","d2","L3000-48","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.51, 0.79, 2.30, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.",{"v":507,"d":"507.00"},"451492-95-8",{"v":100,"d":"100.00"},197.24,"<1","N/A","http://www.selleckchem.com/products/av-412-free-base.html","C27H28ClFN6O","Free base","MP-412 free base","CN1CCN(CC1)C(C)(C)C#CC2=CC3=C(C=C2NC(=O)C=C)C(=NC=N3)NC4=CC(=C(F)C=C4)Cl",5.369,3,2,7]
["S2975","CarboxyaMidotriazole orotate","e2","L3000-48","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate inhibits angiogenesis, tumor growth, invasion, and metastasis.",580.76,"187739-60-2",{"v":25,"d":"25.00"},43.05,"<1","N/A","http://www.selleckchem.com/products/carboxyamidotriazole-orotate.html","C22H16Cl3N7O6","Orotate","L-651582 Orotate, CAI Orotate","NC(=O)C1=C(N)[N](CC2=CC(=C(C(=C2)Cl)C(=O)C3=CC=C(Cl)C=C3)Cl)N=N1.OC(=O)C4=CC(=O)NC(=O)N4",{"v":2.65,"d":"2.650"},7,4,6]
["S3020","Romidepsin","f2","L3000-48","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.",{"v":540.7,"d":"540.70"},"128517-07-7",{"v":10,"d":"10.00"},18.49,"<1","N/A","http://www.selleckchem.com/products/Romidepsin-FK228.html","C24H36N4O6S2","Free base","FK228, Depsipeptide, FR 901228, NSC 630176,","C\\C=C1/NC(=O)C2CSSCC/C=C/C(CC(=O)NC(C(C)C)C(=O)N2)OC(=O)C(NC1=O)C(C)C",1.689,6,4,2]
["S3494","Vicriviroc maleate","g2","L3000-48","in 10mM DMSO","CCR,HIV Protease","GPCR & G Protein","Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.",{"v":649.7,"d":"649.70"},"599179-03-0",{"v":100,"d":"100.00"},153.92,{"v":50,"d":"50.00"},76.96,"http://www.selleckchem.com/products/vicriviroc-maleate.html","C32H42F3N5O6","Maleate","SCH-417690 maleate, SCH-D maleate","COCC(N1CCN(CC1C)C2(C)CCN(CC2)C(=O)C3=C(C)N=CN=C3C)C4=CC=C(C=C4)C(F)(F)F.OC(=O)\\C=C/C(O)=O",-2.926,6,0,9]
["S3520","AZ10606120 dihydrochloride","h2","L3000-48","in 10mM DMSO","P2 Receptor","Neuronal Signaling","AZ10606120 dihydrochloride (2HCl) is a potent and selective antagonist for P2X7 receptor (P2X7R) with IC50 of ~10 nM. AZ10606120 dihydrochloride exhibits anti-depressant effects and reduces tumour growth.",495.48,"607378-18-7",{"v":99,"d":"99.00"},199.81,{"v":17,"d":"17.00"},34.31,"http://www.selleckchem.com/products/az10606120-dihydrochloride.html","C25H36Cl2N4O2","Dihydrochloride","AZ10606120 2HCl","Cl.Cl.OCCNCCNC1=NC2=C(C=C1)C(=CC=C2)NC(=O)CC34CC5CC(CC(C5)C3)C4",3.902,2,4,9]
["S3522","2OH-BNPP1","a3","L3000-48","in 10mM DMSO","Serine/threonin kinase","Metabolism","2OH-BNPP1 is an inhibitor of the kinase activity of BUB1 (budding uninhibited by benzimidazoles-1, BUB1 Mitotic Checkpoint Serine/Threonine Kinase) that can be used for the treatment of cancer.",297.36,"833481-73-5",{"v":59,"d":"59.00"},198.41,"<1","N/A","http://www.selleckchem.com/products/2oh-bnpp1.html","C16H19N5O","Free base","N/A","CC(C)(C)[N]1N=C(CC2=CC=CC=C2O)C3=C(N)N=CN=C13",2.563,3,2,3]
["S3523","AZD7507","b3","L3000-48","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.",{"v":454.5,"d":"454.50"},"1041852-85-0",{"v":91,"d":"91.00"},200.22,"<1","N/A","http://www.selleckchem.com/products/azd7507.html","C23H27FN6O3","Free base","N/A","COC1=CC2=C(C=C1N3CCN(CCO)CC3)C(=C(N=N2)C(N)=O)NC4=C(F)C=C(C)C=C4",2.785,4,3,7]
["S3576","TVB-3166","c3","L3000-48","in 10mM DMSO","Apoptosis related,Fatty Acid Synthase","Metabolism","TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth.",384.47,"1533438-83-3",{"v":77,"d":"77.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/tvb-3166.html","C24H24N4O","Free base","N/A","CC1=C(C)C(=N[NH]1)C2=C(C)C=C(C)C(=C2)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N",4.479,2,1,3]
["S4455","iGOT1-01","d3","L3000-48","in 10mM DMSO","GOT","Metabolism","iGOT1-01, a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor, possesses anti-cancer activity.",320.39,"882256-55-5",{"v":100,"d":"100.00"},312.12,"<1","N/A","http://www.selleckchem.com/products/igot1-01.html","C19H20N4O","Free base","N/A","O=C(NC1=CC=CC=C1)N2CCN(CC2)C3=C4C=C[NH]C4=CC=C3",3.075,1,2,2]
["S4476","PCNA-I1","e3","L3000-48","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","PCNA-I1 is a selective inhibitor of proliferating cell nuclear antigen (PCNA, a potential anticancer target). PCNA-I1 selectively binds to PCNA trimers with Kd of ~0.2 to 0.4 μM. PCNA-I1 inhibits the growth of tumor cells of various tissue types with IC50 of ~0.2 μM. PCNA-I1 induces DNA damage and apoptosis in both LNCaP and PC-3 cells. PCNA-I1 also induces autophagy in PC-3 cells.",310.37,"444930-42-1",{"v":62,"d":"62.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/pcna-i1.html","C17H14N2O2S","Free base","N/A","CC1=C(SC=C1)C(=O)N\\N=C\\C2=C(O)C3=CC=CC=C3C=C2",3.789,2,2,3]
["S6248","Fasnall","f3","L3000-48","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.",338.47,"929978-58-5",{"v":13,"d":"13.00"},38.41,"<1","N/A","http://www.selleckchem.com/products/fasnall.html","C19H22N4S","Free base","N/A","CC1=C(C)C2=C(NC3CCN(C3)CC4=CC=CC=C4)N=CN=C2S1",3.723,2,1,4]
["S6594","Liarozole dihydrochloride","g3","L3000-48","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Liarozole Dihydrochloride is identified as a modest inhibitor of P450 with IC50 of 2.2–6.0 μM and 260 nM for CYP26 and rat CYP17 respectively.",381.69,"1883548-96-6",{"v":76,"d":"76.00"},199.11,{"v":76,"d":"76.00"},199.11,"http://www.selleckchem.com/products/liarozole-dihydrochloride.html","C₁₇H₁₅Cl₃N₄","Dihydrochloride","N/A","Cl.Cl.ClC1=CC=CC(=C1)C([N]2C=CN=C2)C3=CC4=C(C=C3)N=C[NH]4",4.062,2,1,3]
["S6661","VcMMAE","h3","L3000-48","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","VcMMAE (mc-vc-PAB-MMAE), a MMAE derivative with valine-citrulline (Vc) linker,is an Drug-linker Conjugate for antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro  and exert cytotoxic activity.",1316.63,"646502-53-6",{"v":100,"d":"100.00"},75.95,"<1","N/A","http://www.selleckchem.com/products/vcmmae.html","C68H105N11O15","Free base","mc-vc-PAB-MMAE","CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C)C(O)C2=CC=CC=C2)OC)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C(=O)OCC3=CC=C(NC(=O)C(CCCNC(N)=O)NC(=O)C(NC(=O)CCCCCN4C(=O)C=CC4=O)C(C)C)C=C3)C(C)C",{"v":4.79,"d":"4.790"},14,8,39]
["S6839","MRX-2843","a4","L3000-48","in 10mM DMSO","FLT3,Mertk","Protein Tyrosine Kinase","MRX-2843 (UNC2371) is an orally active dual inhibitor of tyrosine kinases MERTK and FLT3 with IC50 of 1.3 nM and 0.64 nM, respectively.",488.67,"1429882-07-4",{"v":98,"d":"98.00"},200.54,"<1","N/A","http://www.selleckchem.com/products/mrx-2843.html","C29H40N6O","Free base","UNC2371","CN1CCN(CC1)CC2=CC=C(C=C2)C3=C[N](C4CCC(O)CC4)C5=NC(=NC=C35)NCCC6CC6",4.459,2,2,8]
["S6840","OSU-T315","b4","L3000-48","in 10mM DMSO","Integrin","Cytoskeletal Signaling","OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.",533.59,"2070015-22-2",{"v":100,"d":"100.00"},187.41,"<1","N/A","http://www.selleckchem.com/products/osu-t315.html","C30H30F3N5O","Free base","ILK-IN-2","CNC(=O)CCC1=CC(=N[N]1C2=CC=C(C=C2)N3CCNCC3)C4=CC=C(C=C4)C5=CC=C(C=C5)C(F)(F)F",5.616,2,2,8]
["S6897","Epertinib hydrochloride","c4","L3000-48","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4 with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity.",596.48,"2071195-74-7",{"v":100,"d":"100.00"},167.65,"<1","N/A","http://www.selleckchem.com/products/epertinib-hydrochloride.html","C30H28Cl2FN5O3","Hydrochloride","Epertinib HCl, S-222611 hydrochloride, S-222611 HCl","Cl.CC#CC(=N\\OCC1COCCN1)/C2=CC3=C(C=C2)N=CN=C3NC4=CC=C(OCC5=CC(=CC=C5)F)C(=C4)Cl",6.684,6,2,10]
["S6961","Foxy-5","d4","L3000-48","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer.",694.77,"881188-51-8",{"v":100,"d":"100.00"},143.93,"<1","N/A","http://www.selleckchem.com/products/foxy5.html","C26H42N6O12S2","Free base","N/A","CSCCC(NC=O)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CS)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(O)=O",-2.779,9,6,23]
["S6984","Dianhydrogalactitol (VAL-083)","e4","L3000-48","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.",146.14,"23261-20-3",{"v":29,"d":"29.00"},198.44,{"v":29,"d":"29.00"},198.44,"http://www.selleckchem.com/products/dianhydrogalactitol-val-083.html","C6H10O4","Free base","Dianhydrodulcitol, Dulcitol Diepoxide","OC(C(O)C1CO1)C2CO2",-1.408,2,2,3]
["S7109","Pevonedistat (MLN4924)","f4","L3000-48","in 10mM DMSO","E1 Activating","Ubiquitin","MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.",443.52,"905579-51-3",{"v":88,"d":"88.00"},198.41,"<1","N/A","http://www.selleckchem.com/products/mln-4924.html","C21H25N5O4S","Free base","N/A","N[S;v6](=O)(=O)OCC1CC(CC1O)[N]2C=CC3=C(NC4CCC5=CC=CC=C45)N=CN=C23",1.543,3,3,6]
["S7554","Ravoxertinib (GDC-0994)","g4","L3000-48","in 10mM DMSO","ERK","MAPK","Ravoxertinib (GDC-0994) is a potent, orally available  and highly selective ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1.",439.85,"1453848-26-4",{"v":87,"d":"87.00"},197.79,"<1","N/A","http://www.selleckchem.com/products/gdc-0994.html","C21H18ClFN6O2","Free base","N/A","C[N]1N=CC=C1NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)C(CO)C4=CC(=C(Cl)C=C4)F",2.798,4,2,6]
["S7682","SAR405","h4","L3000-48","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells.",443.85,"1523406-39-4",{"v":88,"d":"88.00"},198.27,"<1","N/A","http://www.selleckchem.com/products/sar405.html","C19H21ClF3N5O2","Free base","N/A","CC1COCCN1C2=CC(=O)N3CCC(N(CC4=CN=CC(=C4)Cl)C3=N2)C(F)(F)F",2.488,4,0,4]
["S7736","MLN120B","a5","L3000-48","in 10mM DMSO","IκB/IKK","NF-κB","MLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive inhibitor of IkappaB kinase beta (IKKβ) with an IC50 of 45 nM for recombinant IKKβ. MLN120B does not inhibit other IKK isoforms at IC50 below 50 μM.",{"v":366.8,"d":"366.80"},"783348-36-7",{"v":73,"d":"73.00"},199.02,"<1","N/A","http://www.selleckchem.com/products/mln120b.html","C19H15ClN4O2","Free base","ML120B","COC1=C(NC(=O)C2=CC=CN=C2C)C3=C(C=C1Cl)C4=C([NH]3)C=NC=C4",2.737,4,2,3]
["S7801","A-1331852","b5","L3000-48","in 10mM DMSO","Bcl-2","Apoptosis","A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.",658.81,"1430844-80-6",{"v":100,"d":"100.00"},151.79,"<1","N/A","http://www.selleckchem.com/products/a-1331852.html","C38H38N6O3S","Free base","N/A","CC1=C(C=N[N]1CC23CC4CC(CC(C4)C2)C3)C5=CC=C(N=C5C(O)=O)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=C(S8)C=CC=C9",7.295,5,1,7]
["S7926","Lifirafenib (BGB-283)","c5","L3000-48","in 10mM DMSO","EGFR,Raf","MAPK","Lifirafenib (BGB-283, Beigene-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.",478.42,"1446090-79-4",{"v":95,"d":"95.00"},198.57,"<1","N/A","http://www.selleckchem.com/products/bgb-283-bgb283.html","C25H17F3N4O3","Free base","Beigene-283","FC(F)(F)C1=CC=C2N=C([NH]C2=C1)C3C4OC5=CC=C(OC6=C7CCC(=O)N=C7NC=C6)C=C5C34",3.338,5,2,4]
["S7930","Ixabepilone (BMS-247550)","d5","L3000-48","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Ixabepilone (Azaepothilone B, BMS-247550, Ixempra, Aza-epothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.",{"v":506.7,"d":"506.70"},"219989-84-1",{"v":100,"d":"100.00"},197.36,"<1","N/A","http://www.selleckchem.com/products/ixabepilone-bms-247550.html","C27H42N2O5S","Free base","Azaepothilone B, BMS-247550, Ixempra, Aza-epothilone B","CC1CCCC2(C)OC2CC(NC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)C(/C)=C/C3=CSC(=N3)C",3.132,4,3,2]
["S8064","Midostaurin (PKC412)","e5","L3000-48","in 10mM DMSO","PKC","Cytoskeletal Signaling","Midostaurin (pkc412, CGP 41251) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.",570.64,"120685-11-2",{"v":100,"d":"100.00"},175.24,"<1","N/A","http://www.selleckchem.com/products/midostaurin-pkc412.html","C35H30N4O4","Free base","CGP 41251","COC1C(CC2OC1(C)[N]3C4=C(C=CC=C4)C5=C3C6=C(C7=C(C=CC=C7)[N]26)C8=C5CNC8=O)N(C)C(=O)C9=CC=CC=C9",5.279,4,1,3]
["S8129","Salinomycin (from Streptomyces albus)","f5","L3000-48","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Salinomycin (Coxistac, Bio-cox, Procoxacin), traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects.",{"v":751,"d":"751.00"},"53003-10-4",{"v":100,"d":"100.00"},133.16,"<1","N/A","http://www.selleckchem.com/products/salinomycin.html","C42H70O11","Free base","Coxistac, Bio-cox, Procoxacin","CCC(C1CCC(C)C(O1)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O",5.904,7,2,12]
["S8341","TAK-243 (MLN7243)","g5","L3000-48","in 10mM DMSO","Apoptosis related,E1 Activating,NF-κB","Ubiquitin","TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NFκB pathway activation and promotes apoptosis.",519.52,"1450833-55-2",{"v":100,"d":"100.00"},192.49,"<1","N/A","http://www.selleckchem.com/products/tak-243-mln243.html","C19H20F3N5O5S2","Free base","N/A","N[S;v6](=O)(=O)OCC1CC(NC2=CC=NC3=CC(=N[N]23)C4=CC(=CC=C4)SC(F)(F)F)C(O)C1O",2.805,3,4,8]
["S8524","Edicotinib(JNJ-40346527)","h5","L3000-48","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM.",{"v":461.6,"d":"461.60"},"1142363-52-7",{"v":92,"d":"92.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/edicotinib.html","C27H35N5O2","Free base","N/A","CC1(C)CCC(=CC1)C2=NC(=CC=C2NC(=O)C3=NC=C([NH]3)C#N)C4CC(C)(C)OC(C)(C)C4",{"v":4.56,"d":"4.560"},4,2,4]
["S8532","ARV-771","a6","L3000-48","in 10mM DMSO","PROTAC","Others","ARV-771 is a potent pan-(bromodomain and extra-terminal)BET degrader, a novel BET-PROTAC(proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.",986.64,"1949837-12-0",{"v":100,"d":"100.00"},101.35,"<1","N/A","http://www.selleckchem.com/products/arv-771.html","C49H60ClN9O7S2","Free base","N/A","CC(NC(=O)C1CC(O)CN1C(=O)C(NC(=O)COCCCOCCNC(=O)CC2N=C(C3=CC=C(Cl)C=C3)C4=C(SC(=C4C)C)[N]5C(=NN=C25)C)C(C)(C)C)C6=CC=C(C=C6)C7=C(C)N=CS7",4.176,10,4,19]
["S8563","TVB-3664","b6","L3000-48","in 10mM DMSO","Fatty Acid Synthase","Metabolism","TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.",468.47,"2097262-58-1",{"v":94,"d":"94.00"},200.65,"<1","N/A","http://www.selleckchem.com/products/tvb-3664.html","C25H23F3N4O2","Free base","N/A","COCC1=C([NH]C(=N1)C(F)(F)F)C2=C(C)C=C(C)C(=C2)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N",4.522,3,1,6]
["S8636","Selitrectinib (LOXO-195)","c6","L3000-48","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.",380.42,"2097002-61-2",{"v":38,"d":"38.00"},99.89,"<1","N/A","http://www.selleckchem.com/products/loxo-195.html","C20H21FN6O","Free base","BAY 2731954","CC1CCC2=C(C=C(F)C=N2)C3CCCN3C4=NC5=C(C=N[N]5C=C4)C(=O)N1",2.056,4,1,0]
["S8665","GNE-781","d6","L3000-48","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.",525.59,"1936422-33-1",{"v":100,"d":"100.00"},190.26,"<1","N/A","http://www.selleckchem.com/products/gne-781.html","C27H33F2N7O2","Free base","N/A","CNC(=O)N1CCC2=C(C1)C(=N[N]2C3CCOCC3)N4CCCC5=C4C=C(C(F)F)C(=C5)C6=C[N](C)N=C6",3.172,4,1,4]
["S8681","Tolinapant (ASTX660)","e6","L3000-48","in 10mM DMSO","IAP","Metabolism","Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.",539.68,"1799328-86-1",{"v":100,"d":"100.00"},185.29,"<1","N/A","http://www.selleckchem.com/products/astx660.html","C30H42FN5O3","Free base","N/A","CC1CN(CC(=O)N2CC(C)(C)C3=C2C=C(CC4=CC=C(F)C=C4)C(=N3)CO)C(CN1)CN5CCOCC5C",{"v":2.93,"d":"2.930"},3,2,7]
["S8707","ARS-1620","f6","L3000-48","in 10mM DMSO","Ras","Cell Cycle","ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRASG12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.",430.84,"1698055-85-4",{"v":86,"d":"86.00"},199.61,"<1","N/A","http://www.selleckchem.com/products/ars-1620.html","C21H17ClF2N4O2","Free base","N/A","OC1=CC=CC(=C1C2=C(F)C3=C(C=C2Cl)C(=NC=N3)N4CCN(CC4)C(=O)C=C)F",4.355,3,1,3]
["S8708","AZD0364 (ATG-017)","g6","L3000-48","in 10mM DMSO","ERK","MAPK","AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2.",{"v":494.5,"d":"494.50"},"2097416-76-5",{"v":99,"d":"99.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://www.selleckchem.com/products/azd0364.html","C24H24F2N8O2","Free base","N/A","COCC1C[N]2C=C(N=C2C(=O)N1CC3=CC(=C(F)C=C3)F)C4=NC(=NC=C4C)NC5=CC=N[N]5C",3.383,6,1,7]
["S8716","Pralsetinib (BLU-667)","h6","L3000-48","in 10mM DMSO","c-RET","Apoptosis","Pralsetinib (BLU-667, CS 3009, Gavreto) is a highly potent and selective RET (c-RET) inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T).",{"v":533.6,"d":"533.60"},"2097132-94-8",{"v":100,"d":"100.00"},187.41,"<1","N/A","http://www.selleckchem.com/products/blu-667.html","C27H32FN9O2","Free base","CS 3009, Gavreto","COC1(CCC(CC1)C2=NC(=CC(=N2)NC3=N[NH]C(=C3)C)C)C(=O)NC(C)C4=CN=C(C=C4)[N]5C=C(F)C=N5",3.716,7,3,8]
["S8718","RMC-4550","a7","L3000-48","in 10mM DMSO","phosphatase","Metabolism","RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.",437.36,"2172651-73-7",{"v":100,"d":"100.00"},228.64,"<1","N/A","http://www.selleckchem.com/products/rmc-4550.html","C21H26Cl2N4O2","Free base","N/A","CC1OCC2(CCN(CC2)C3=C(CO)N=C(C(=N3)C)C4=C(Cl)C(=CC=C4)Cl)C1N",2.936,3,2,3]
["S8720","Imaradenant (AZD4635)","b7","L3000-48","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.",315.73,"1321514-06-0",{"v":63,"d":"63.00"},199.54,"<1","N/A","http://www.selleckchem.com/products/adz-4635.html","C15H11ClFN5","Free base","HTL1071","CC1=CC(=CC(=N1)Cl)C2=NN=C(N)N=C2C3=CC=C(F)C=C3",3.463,4,1,2]
["S8722","Samuraciclib hydrochloride (ICEC0942 hydrochloride)","c7","L3000-48","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.",430.97,"1805789-54-1",{"v":86,"d":"86.00"},199.55,{"v":86,"d":"86.00"},199.55,"http://www.selleckchem.com/products/icec0942-hydrochloride.html","C22H31ClN6O","Hydrochloride","CT7001 hydrochloride","Cl.CC(C)C1=C2N=C(NCC3CCNCC3O)C=C(NCC4=CC=CC=C4)[N]2N=C1",{"v":3.15,"d":"3.150"},2,4,7]
["S8782","LY3295668","d7","L3000-48","in 10mM DMSO","Aurora Kinase","Cell Cycle","LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.",489.95,"1919888-06-4",{"v":98,"d":"98.00"},200.02,"<1","N/A","http://www.selleckchem.com/products/ly3295668.html","C24H26ClF2N5O2","Free base","AK-01","CC1CC(CCN1CC2=C(F)C(=CC=C2)Cl)(CC3=NC(=CC=C3F)NC4=N[NH]C(=C4)C)C(O)=O",2.403,3,2,7]
["S8829","Subasumstat (TAK-981)","e7","L3000-48","in 10mM DMSO","SUMO","Ubiquitin","Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.",{"v":578.1,"d":"578.10"},"1858276-04-6",{"v":100,"d":"100.00"},172.98,"<1","N/A","http://www.selleckchem.com/products/tak-981.html","C25H28ClN5O5S2","Free base","N/A","CC1=C(C=C(S1)C(=O)C2=C(NC3CC(O)C(CO[S](N)(=O)=O)C3)N=CN=C2)C4NCCC5=C4C=C(Cl)C=C5",2.094,4,4,8]
["S8830","Sotorasib (AMG510)","f7","L3000-48","in 10mM DMSO","Ras","Cell Cycle","Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.",560.59,"2296729-00-3",{"v":100,"d":"100.00"},178.38,"<1","N/A","http://www.selleckchem.com/products/amg510.html","C30H30F2N6O3","Free base","N/A","CC(C)C1=C(N2C(=O)N=C(N3CCN(CC3C)C(=O)C=C)C4=CC(=C(N=C24)C5=C(F)C=CC=C5O)F)C(=CC=N1)C",5.357,5,1,5]
["S8834","GB1107","g7","L3000-48","in 10mM DMSO","Galectin","Immunology & Inflammation","GB1107 is a potent, selective, inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3.",522.32,"1978336-61-6",{"v":100,"d":"100.00"},191.45,"<1","N/A","http://www.selleckchem.com/products/gb1107.html","C20H16Cl2F3N3O4S","Free base","N/A","OCC1OC(SC2=CC=C(Cl)C(=C2)Cl)C(O)C(C1O)[N]3C=C(N=N3)C4=CC(=C(F)C(=C4)F)F",4.479,3,3,5]
["S8849","TAS4464","h7","L3000-48","in 10mM DMSO","E1 Activating","Ubiquitin","TAS4464 is a potent and highly selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. TAS4464 exhibits superior antitumor activity with prolonged target inhibition.",506.51,"1848959-10-3",{"v":100,"d":"100.00"},197.43,"<1","N/A","http://www.selleckchem.com/products/tas4464.html","C21H23FN6O6S","Free base","N/A","CCOC1=CC=CC(=C1C#CC2=C[N](C3OC(CN[S](N)(=O)=O)C(O)C3O)C4=C2C(=NC=N4)N)F",0.246,6,5,8]
["S8858","GSK3368715 (EPZ019997) 3HCl","a8","L3000-48","in 10mM DMSO","PRMT","Methylation","GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.",475.92,"2227587-26-8",{"v":81,"d":"81.00"},{"v":170.2,"d":"170.20"},{"v":81,"d":"81.00"},{"v":170.2,"d":"170.20"},"http://www.selleckchem.com/products/gsk3368715.html","C20H41Cl3N4O2","Trihydrochloride","N/A","Cl.Cl.Cl.CCOCC1(CCC(CC1)C2=N[NH]C=C2CN(C)CCNC)COCC",3.296,3,2,12]
["S8860","Cintirorgon (LYC-55716)","b8","L3000-48","in 10mM DMSO","ROR","Metabolism","Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.",603.53,"2055536-64-4",{"v":100,"d":"100.00"},165.69,"<1","N/A","http://www.selleckchem.com/products/cintirorgon-lyc-55716.html","C27H23F6NO6S","Free base","N/A","CC(C)(CC1CN(C2=CC(=CC=C2O1)C3=CC(=CC(=C3)F)OC(F)F)[S;v6](=O)(=O)C4=CC(=CC=C4)C(F)(F)F)C(O)=O",6.756,5,0,9]
["S8869","UNBS5162","c8","L3000-48","in 10mM DMSO","CXCR","Immunology & Inflammation","UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity (IC50 range of 0.5-5 µM) against a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7).",326.35,"956590-23-1",{"v":17,"d":"17.00"},52.09,"<1","N/A","http://www.selleckchem.com/products/unbs5162.html","C17H18N4O3","Free base","N/A","CN(C)CCN1C(=O)C2=CC=CC3=C2C(=CC(=C3)NC(N)=O)C1=O",0.819,3,2,4]
["S8881","DS-1001b (DS 1001)","d8","L3000-48","in 10mM DMSO","Dehydrogenase","Metabolism","DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier.",608.92,"1898207-64-1",{"v":14,"d":"14.00"},22.99,"<1","N/A","http://www.selleckchem.com/products/ds-1001b.html","C29H29Cl3FN3O4","Free base","DS-1001","CC1=C[N](C(=O)C2=C(ON=C2C3=C(Cl)C=C(Cl)C=C3Cl)C(C)(C)F)C4=CC=CC(=C14)\\C=C\\C(O)=O.CC(C)(C)N",{"v":5.77,"d":"5.770"},4,1,5]
["S8884","Adagrasib (MRTX849)","e8","L3000-48","in 10mM DMSO","Ras","Cell Cycle","Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling.",604.12,"2326521-71-3",{"v":100,"d":"100.00"},165.53,"<1","N/A","http://www.selleckchem.com/products/mrtx849.html","C32H35ClFN7O2","Free base","N/A","CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN(C(CC#N)C6)C(=O)C(F)=C",5.325,4,0,7]
["S8925","Simurosertib","f8","L3000-48","in 10mM DMSO","CDK","Cell Cycle","Simurosertib (TAK-931), an oral cell division cycle 7 (CDC7)-selective inhibitor with an IC50<0.3 nM, induces S phase delay and replication stress and causes mitotic aberrations through centrosome dysregulation and chromosome missegregation, resulting in irreversible antiproliferative effects in cancer cells.",341.43,"1330782-76-7",{"v":68,"d":"68.00"},199.16,"<1","N/A","http://www.selleckchem.com/products/simurosertib.html","C17H19N5OS","Free base","TAK-931","CC1=N[NH]C=C1C2=CC3=C(S2)C(=O)NC(=N3)C4CC5CCN4CC5",2.218,3,2,2]
["S8926","Valemetostat (DS-3201)","g8","L3000-48","in 10mM DMSO","EZH1/2","Methylation","Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor.",488.02,"1809336-39-7",{"v":100,"d":"100.00"},204.91,"<1","N/A","http://www.selleckchem.com/products/valemetostat-ds-3201.html","C26H34ClN3O4","Free base","DS-3201b","CN(C)C1CCC(CC1)C2(C)OC3=C(Cl)C=C(C(=O)NCC4=C(C)C=C(C)NC4=O)C(=C3O2)C",3.963,4,2,5]
["S8934","VTP50469","h8","L3000-48","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.",630.82,"2169916-18-9",{"v":100,"d":"100.00"},158.52,"<1","N/A","http://www.selleckchem.com/products/vtp50469.html","C32H47FN6O4S","Free base","N/A","CC(C)N(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](C)(=O)=O)C3)C=CC(=C1)F",4.089,6,1,10]
["S8955","Sotorasib (AMG510) racemate","a9","L3000-48","in 10mM DMSO","Ras","Cell Cycle","Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.",560.59,"2252403-56-6",{"v":100,"d":"100.00"},178.38,"<1","N/A","http://www.selleckchem.com/products/amg-510-racemate.html","C30H30F2N6O3","Free base","N/A","CC(C)C1=C(N2C(=O)N=C(N3CCN(CC3C)C(=O)C=C)C4=CC(=C(N=C24)C5=C(F)C=CC=C5O)F)C(=CC=N1)C",5.357,5,1,5]
["S8958","Camizestrant (AZD9833)","b9","L3000-48","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Camizestrant (AZD9833) is an orally available and selective estrogen receptor (ER) antagonist with antineoplastic activity.",476.51,"2222844-89-3",{"v":95,"d":"95.00"},199.37,"<1","N/A","http://www.selleckchem.com/products/azd9833.html","C24H28F4N6","Free base","N/A","CC1CC2=C(C=CC3=C2C=N[NH]3)C(N1CC(F)(F)F)C4=NC=C(NC5CN(CCCF)C5)C=C4",4.048,2,2,8]
["S8987","TNO155","c9","L3000-48","in 10mM DMSO","phosphatase","Metabolism","TNO155 is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2 /src homology region 2 domain phosphatase /PTPN11) with IC50 of 0.011 µM. TNO155 has potential antineoplastic activity.",421.95,"1801765-04-7",{"v":84,"d":"84.00"},199.08,"<1","N/A","http://www.selleckchem.com/products/tno155.html","C18H24ClN7OS","Free base","N/A","CC1OCC2(CCN(CC2)C3=CN=C(SC4=C(Cl)C(=NC=C4)N)C(=N3)N)C1N",1.523,4,3,3]
["S8999","Exatecan Mesylate","d9","L3000-48","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Exatecan Mesylate (DX-8951f) is a water-soluble and non-pro-drug analog of camptothecin and shows significant topoisomerase I inhibition with IC50 of 0.975 μg/ml.",531.55,"169869-90-3",{"v":12.5,"d":"12.50"},23.52,{"v":12.5,"d":"12.50"},23.52,"http://www.selleckchem.com/products/exatecan-mesylate.html","C24H22FN3O4.CH4O3S","Mesylate","DX-8951 Mesylate","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C5C(N)CCC6=C5C(=CC(=C6C)F)N=C34)C2=O.C[S](O)(=O)=O",1.689,4,1,1]
["S9522","Valrubicin","e9","L3000-48","in 10mM DMSO","PKC","TGF-beta/Smad","Valrubicin(AD-32) is a chemotherapy drug used to treat bladder cancer. Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively.",723.64,"56124-62-0",{"v":100,"d":"100.00"},138.19,"<1","N/A","http://www.selleckchem.com/products/valrubicin.html","C34H36F3NO13","Free base","AD-32","CCCCC(=O)OCC(=O)C1(O)CC(OC2CC(NC(=O)C(F)(F)F)C(O)C(C)O2)C3=C(C1)C(=C4C(=O)C5=C(C(=O)C4=C3O)C(=CC=C5)OC)O",3.024,9,4,12]
["S9608","Etrumadenant (AB928)","f9","L3000-48","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Etrumadenant (AB928, A2aR/A2bR antagonist-1) is a novel dual A2aR/A2bR antagonist with Kd of 1.4 nM and 2 nM for A2aR and A2bR, respectively.",426.47,"2239273-34-6",{"v":85,"d":"85.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/ab928.html","C23H22N8O","Free base","A2aR/A2bR antagonist-1","CC1=C(C=CC=C1C#N)C2=CC(=NC(=N2)N)C3=C[N](CC4=CC=CC(=N4)C(C)(C)O)N=N3",{"v":3.75,"d":"3.750"},5,1,5]
["S9629","Elacestrant (RAD1901) Dihydrochloride","g9","L3000-48","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Elacestrant (RAD1901) Dihydrochloride is an orally available selective estrogen receptor degrader (SERD) with IC50 of 48 nM and 870 nM for ERα and ERβ, respectively.",531.56,"1349723-93-8",{"v":100,"d":"100.00"},188.13,{"v":25,"d":"25.00"},47.03,"http://www.selleckchem.com/products/elacestrant.html","C30H40Cl2N2O2","Dihydrochloride","N/A","Cl.Cl.CCNCCC1=CC=C(CN(CC)C2=C(C=CC(=C2)OC)C3CCC4=C(C3)C=CC(=C4)O)C=C1",7.434,1,2,10]
["S9638","BRD0705","h9","L3000-48","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).",321.42,"2056261-41-5",{"v":64,"d":"64.00"},199.12,"<1","N/A","http://www.selleckchem.com/products/brd0705.html","C20H23N3O","Free base","N/A","CCC1(C2=CC=CC=C2)C3=CNNC3=NC4=C1C(=O)CC(C)(C)C4",2.053,2,2,2]
["S9650","LY3143921 hydrate","a10","L3000-48","in 10mM DMSO","CDK","Cell Cycle","LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.",327.31,"1627696-53-0",{"v":65,"d":"65.00"},198.59,"<1","N/A","http://www.selleckchem.com/products/ly3143921-hydrate.html","C16H14FN5O2","Hydrate","N/A","O.CC1(NC(=O)C2=CC(=CC=C12)C3=C[NH]N=C3)C4=NC=NC=C4F",1.219,4,2,2]
["S9691","BMS-986158","b10","L3000-48","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BMS-986158 is a potent inhibitor of BET with IC50s of 6.6 nM and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.",495.62,"1800340-40-2",{"v":25,"d":"25.00"},50.44,"<1","N/A","http://www.selleckchem.com/products/bms-986158.html","C30H33N5O2","Free base","N/A","C[N]1N=NC(=C1C2=CC3=C(N=C2)C4=C(C=C(C=C4)C(C)(C)O)[N]3C(C5CCOCC5)C6=CC=CC=C6)C",5.091,4,0,5]
["S9726","Rimiducid (AP1903)","c10","L3000-48","in 10mM DMSO","FKBP","Apoptosis","Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target FKBP fusion protein while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM.",1411.63,"195514-63-7",{"v":100,"d":"100.00"},70.84,"<1","N/A","http://www.selleckchem.com/products/rimiducid-ap1903.html","C78H98N4O20","Free base","N/A","CCC(C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(OC)C=C2)OC)C3=CC(=CC=C3)OCC(=O)NCCNC(=O)COC4=CC=CC(=C4)C(CCC5=CC(=C(OC)C=C5)OC)OC(=O)C6CCCCN6C(=O)C(CC)C7=CC(=C(OC)C(=C7)OC)OC)C8=CC(=C(OC)C(=C8)OC)OC",11.602,20,2,39]
["S9825","Pirtobrutinib (LOXO-305)","d10","L3000-48","in 10mM DMSO","BTK","Angiogenesis","Pirtobrutinib (LOXO-305, LY 3527727, RXC-005) is a highly selective, non-covalent, next generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells. Pirtobrutinib shows more than 300-fold selective for BTK over 98% of 370 other kinases.",479.43,"2101700-15-4",{"v":96,"d":"96.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/pirtobrutinib-loxo-305.html","C22H21F4N5O3","Free base","LY 3527727, RXC-005","COC1=CC=C(F)C=C1C(=O)NCC2=CC=C(C=C2)C3=N[N](C(C)C(F)(F)F)C(=C3C(N)=O)N",3.172,4,3,8]
["S9867","LY-3475070","e10","L3000-48","in 10mM DMSO","CD markers","Transmembrane Transporters","LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).",286.33,"2375815-63-5",{"v":57,"d":"57.00"},199.07,"<1","N/A","http://www.selleckchem.com/products/ly-3475070.html","C15H18N4O2","Free base","N/A","CC(C)C1CC1C2=CC(=NN=C2C)C3=CNC(=O)NC3=O",1.342,4,2,3]
["S9901","KB-0742 Dihydrochloride","f10","L3000-48","in 10mM DMSO","CDK","Cell Cycle","KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.",360.33,"2416874-75-2",{"v":72,"d":"72.00"},199.82,{"v":72,"d":"72.00"},199.82,"http://www.selleckchem.com/products/kb-0742-dihydrochloride.html","C16H25N5.2ClH","Dihydrochloride","N/A","Cl.Cl.CCC(CC)C1=NC2=CC=N[N]2C(=C1)NC3CCC(N)C3",3.291,2,2,5]
["S9970","APG-2575 (lisaftoclax)","g10","L3000-48","in 10mM DMSO","Bcl-2","Apoptosis","APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.",882.43,"2180923-05-9",{"v":100,"d":"100.00"},113.32,"<1","N/A","http://www.selleckchem.com/products/apg-2575-lisaftoclax.html","C45H48ClN7O8S","Free base","N/A","ClC1=CC=C(C=C1)C2=C(CCC3(CCC3)C2)CN4CCN(CC4)C5=CC(=C(C=C5)C(=O)N[S;v6](=O)(=O)C6=CC(=C(NCC7COCCO7)C=C6)[N;v5](=O)=O)OC8=CN=C9[NH]C=CC9=C8",7.191,7,3,13]
["S9975","ASN007","h10","L3000-48","in 10mM DMSO","ERK","MAPK","ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations.",473.93,"2055597-12-9",{"v":95,"d":"95.00"},200.45,"<1","N/A","https://www.selleckchem.com/products/asn007.html","C22H25ClFN7O2","Free base","ERAS 007,ERK-IN-3","CC1=CN=C(NC2CCOCC2)N=C1[N]3C=NC(=C3)C(=O)NC(CN)C4=CC(=CC(=C4)F)Cl",2.206,5,3,7]
["E0142","XL092","a11","L3000-48","in 10mM DMSO","Axl,c-Met,Mertk,VEGFR","Protein Tyrosine Kinase","XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.",528.53,"2367004-54-2",{"v":100,"d":"100.00"},{"v":189.2,"d":"189.20"},"<1","N/A","http://www.selleckchem.com/products/xl092.html","C29H25FN4O5","Free base","JUN04542","CNC(=O)C1=CC2=C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3)C=CN=C2C=C1OC",3.567,6,3,8]
["E0146","PF-9363 (CTx-648)","b11","L3000-48","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","PF-9363 (CTx-648) is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.",444.46,"2569009-58-9",{"v":89,"d":"89.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/pf-9363-ctx-648.html","C20H20N4O6S","Free base","N/A","COC1=CC(=CC2=C1C(=NO2)N[S](=O)(=O)C3=C(OC)C=CC=C3OC)C[N]4C=CC=N4",2.694,8,1,8]
["E0369","Endovion (NS 3728)","c11","L3000-48","in 10mM DMSO","VRAC","Transmembrane Transporters","Endovion (NS 3728, SCO-101) is a potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).",495.18,"265646-85-3",{"v":100,"d":"100.00"},201.95,"<1","N/A","http://www.selleckchem.com/products/endovion-ns-3728.html","C16H9BrF6N6O","Free base","SCO-101","FC(F)(F)C1=CC(=CC(=C1)NC(=O)NC2=CC=C(Br)C=C2C3=NN=N[NH]3)C(F)(F)F",4.185,4,3,5]
["E0488","BC-LI-0186","d11","L3000-48","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","BC-LI-0186 is a selective blocker of Leucyl-tRNA synthetase (LRS, LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (LRS-RagD interaction) (IC50 = 46.11 nM) by competing against RagD for LRS VC domain binding (KD = 42.1 nM), thereby inhibiting lysosomal localization of LRS and mTORC1 activity. It also effectively suppresses the activity of cancer-associated mTOR mutants and the growth of rapamycin-resistant cancer cells.",429.53,"695207-56-8",{"v":86,"d":"86.00"},413.04,"<1","N/A","http://www.selleckchem.com/products/bc-li-0186.html","C9H12BNO4","Free base","N/A","CC(C)C1=C(C)N(C)N(C1=O)C2=CC=C(C=C2)[S](=O)(=O)NCCOC3=CC=CC=C3",2.916,4,1,8]
["E0496","ZLc002","e11","L3000-48","in 10mM DMSO","NOS","Immunology & Inflammation","ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain.",231.25,"308277-46-5",{"v":46,"d":"46.00"},198.92,{"v":46,"d":"46.00"},198.92,"http://www.selleckchem.com/products/zlc002.html","C10H17NO5","Free base","N/A","COC(=O)CC(=O)NC(C(C)C)C(=O)OC",0.444,5,1,7]
["E0499","4SC-203","f11","L3000-48","in 10mM DMSO","VEGFR","Epigenetics","4SC-203 (SC71710) is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs).",642.77,"895533-09-2",{"v":100,"d":"100.00"},155.58,"<1","N/A","http://www.selleckchem.com/products/4sc-203.html","C33H38N8O4S","Free base","SC 71710","COC1=C(NC(=O)NC2=NC3=C(S2)C=C(NC4=NC=NC5=CC(=C(OC)C=C45)OCCCN6CCN(C)CC6)C=C3)C=C(C)C=C1",5.391,7,3,11]
["E0616","Chiauranib","g11","L3000-48","in 10mM DMSO","Aurora Kinase,c-Kit,CSF-1R,PDGFR,VEGFR","Protein Tyrosine Kinase","Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.",{"v":435.5,"d":"435.50"},"1256349-48-0",{"v":87,"d":"87.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/chiauranib.html","C27H21N3O3","Free base","CS2164","COC1=CC2=C(C=C1)C(=CC=N2)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=C(N)C=CC=C5",4.506,4,2,5]
["E0742","Melengestrol Acetate","h11","L3000-48","in 10mM DMSO","CYP450","Metabolism","Melengestrol Acetate, progestational steroid  suppress the AT3 tumour.",396.52,"2919-66-6",{"v":10,"d":"10.00"},25.22,"<1","N/A","http://www.selleckchem.com/products/melengestrol-acetate.html","C25H32O4","Acetate","N/A","CC(=O)OC1(C(C)=O)C(=C)CC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C",3.696,4,0,3]
["E1000","Zn-C3","a2","L3000-49","in 10mM DMSO","Wee1","Cell Cycle","ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.",526.63,"2376146-48-2",{"v":100,"d":"100.00"},189.89,"<1","N/A","http://www.selleckchem.com/products/zn-c3.html","C29H34N8O2","Free base","N/A","CCC1(O)CCC2=CC=C(N=C12)N3N(CC=C)C(=O)C4=CN=C(NC5=CC=C(C=C5)N6CCN(C)CC6)N=C34",4.864,4,1,7]
["E1037","ZZW-115","b2","L3000-49","in 10mM DMSO","Others","Others","ZZW-115 is a potent NUPR1 inhibitor with IC50s of 0.42 μM in Hep2G cells and 7.75 μM in SaOS-2 cells. ZZW-115 shows evident antitumor activity through its interaction with NUPR1.",573.97,"10122-45-9",{"v":93,"d":"93.00"},162.03,{"v":46,"d":"46.00"},80.14,"http://www.selleckchem.com/products/zzw-115.html","C₂₄H₃₄Cl₃F₃N₄S","Free base","N/A","Cl.Cl.Cl.CN(C)CCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CC1",6.259,0,0,8]
["E1091","Relacorilant","c2","L3000-49","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.",586.56,"1496510-51-0",{"v":100,"d":"100.00"},170.49,"<1","N/A","http://www.selleckchem.com/products/relacorilant.html","C27H22F4N6O3S","Free base","CORT125134","C[N]1C=C(C=N1)[S;v6](=O)(=O)N2CCC3=CC4=C(CC3(C2)C(=O)C5=CC(=CC=N5)C(F)(F)F)C=N[N]4C6=CC=C(F)C=C6",4.117,6,0,6]
["E1103","AU-15330","d2","L3000-49","in 10mM DMSO","PROTAC","Others","AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, which can induce potent inhibition of tumor growth in xenograft models of prostate cancer.",755.93,"2380274-50-8",{"v":100,"d":"100.00"},132.29,"<1","N/A","http://www.selleckchem.com/products/au-15330.html","C39H49N9O5S","Free base","N/A","CC(NC(=O)C1CC(O)CN1C(=O)C(NC(=O)CN2CCN(CC2)C3=C(N)N=NC(=C3)C4=C(O)C=CC=C4)C(C)(C)C)C5=CC=C(C=C5)C6=C(C)N=CS6",2.829,6,5,11]
["E1113","GSK215","e2","L3000-49","in 10mM DMSO","FAK","Protein Tyrosine Kinase","GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader, which exerts FAK degradation in A549 non-small-cell lung cancer cells with DC50 of 1.3 nM by a strong time-dependence way and maximal degradation (Dmax) near the limit of the assay quantification (Dmax 99%).",985.13,"2743427-26-9",{"v":100,"d":"100.00"},101.51,"<1","N/A","http://www.selleckchem.com/products/gsk215.html","C50H59F3N10O6S","Free base","N/A","CNC(=O)C1=C(NC2=CC(=NC=C2C(F)(F)F)NC3=C(OC)C=C(C=C3)N4CCN(CC4)CC(=O)NC(C(=O)N5CC(O)CC5C(=O)NC(C)C6=CC=C(C=C6)C7=C(C)N=CS7)C(C)(C)C)C=CC=C1",5.572,7,6,17]
["E1149","BAY-179","f2","L3000-49","in 10mM DMSO","OXPHOS","Metabolism","BAY-179 is an excellent in vivo suitable tool with which to probe the biological relevance of complex I inhibition in cancer indications.",415.51,"2764880-87-5",{"v":5,"d":"5.00"},12.03,"<1","N/A","http://www.selleckchem.com/products/bay-179.html","C23H21N5OS","Free base","N/A","C1CN(CCC1C2=NC(=CS2)C3=CC4=CC=CC=C4O3)CC5=NC6=NC=CC=C6[NH]5",4.052,4,1,4]
["E1179","EZM0414","g2","L3000-49","in 10mM DMSO","SETD","Methylation","EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.",400.49,"2411748-50-8",{"v":40,"d":"40.00"},99.88,"<1","N/A","http://www.selleckchem.com/products/ezm0414.html","C22H29FN4O2","Free base","N/A","CC(=O)N1CCN(CC1)C2CCCC(C2)NC(=O)C3=CC4=C(F)C=CC(=C4[NH]3)C",2.707,2,2,3]
["E1180","Sovilnesib","h2","L3000-49","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.",564.65,"2410796-79-9",{"v":100,"d":"100.00"},{"v":177.1,"d":"177.10"},"<1","N/A","http://www.selleckchem.com/products/sovilnesib.html","C26H34F2N6O4S","Free base","AMG 650","CC1=CC(=NC(=N1)N2CCC(F)(F)CC2)NC(=O)C3=C(C=C(N[S;v6](=O)(=O)CCO)C=C3)N4CCC5(CC4)CC5",2.699,5,3,8]
["E1183","MRTX0902","a3","L3000-49","in 10mM DMSO","Others","Others","MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM.",388.47,"2654743-22-1",{"v":100,"d":"100.00"},257.42,"<1","N/A","http://www.selleckchem.com/products/mrtx0902.html","C22H24N6O","Free base","N/A","CC(NC1=NN=C(C)C2=C1C=C(N=C2)N3CCOCC3)C4=C(C)C(=CC=C4)C#N",3.315,4,1,4]
["E1184","CFT7455","b3","L3000-49","in 10mM DMSO","Others","Others","CFT7455 is an orally active zinc finger transcription factors (IKZF1) (Ikaros) and IKZF3 (Aiolos) degrader. It binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM). It is used in the treatment of multiple myeloma & non-Hodgkin’s lymphoma.",469.53,"2504235-67-8",{"v":94,"d":"94.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/cft7455.html","C28H27N3O4","Free base","N/A","O=C1CCC(N2C(=O)C3=C4C2=CC=C(CC5=CC=C(CN6CCOCC6)C=C5)C4=CC=C3)C(=O)N1",2.869,4,1,5]
["E1191","GDC-1971","c3","L3000-49","in 10mM DMSO","phosphatase","Metabolism","GDC-1971 (compound 199) is a SHP2 inhibitor.",454.54,"2377352-49-1",{"v":91,"d":"91.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/gdc-1971.html","C25H26N8O","Free base","compound 199","NC1C2=CC=CC=C2OC13CCN(CC3)C4=CN=C5C(=N4)[NH]N=C5N6CCCC7=NC=CC=C67",2.597,5,2,2]
["E1204","NVP-DKY709","d3","L3000-49","in 10mM DMSO","Others","Others","NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.",985.13,"2291360-73-9",{"v":10,"d":"10.00"},10.15,"<1","N/A","http://www.selleckchem.com/products/nvp-dky709.html","C50H59F3N10O6S","Free base","N/A","O=C1CCC(N2CC3=CC(=CC=C3C2=O)C4CCN(CC4)CC5=CC=CC=C5)C(=O)N1",2.507,3,1,4]
["E1205","BAY 2666605","e3","L3000-49","in 10mM DMSO","PDE","Metabolism","BAY 2666605 is an orally active phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) inhibitor with IC50s of 87 nM and 50 nM, respectively.",352.28,"2275774-60-0",{"v":70,"d":"70.00"},198.71,"<1","N/A","http://www.selleckchem.com/products/bay-2666605.html","C17H12F4N2O2","Free base","N/A","CC1OC(=O)NN=C1C2=CC=C(C3=CC=C(F)C=C3)C(=C2)C(F)(F)F",4.479,3,1,3]
["E1208","NPX800","f3","L3000-49","in 10mM DMSO","HSP (HSP90)","Metabolism","NPX800 is a potent heat shock factor 1 (HSF1) inhibitor, which has the potential for cancer research.",569.63,"1693734-80-3",{"v":100,"d":"100.00"},175.55,"<1","N/A","http://www.selleckchem.com/products/npx800.html","C32H32FN5O4","Free base","N/A","CCN1CCN(CC1)CC2=NC3=C(C=C2)C=C(C=C3)C(=O)NC4=CC(=CC=C4F)NC(=O)C5=CC=C6OCCOC6=C5",4.171,5,2,7]
["E1212","CC-99282","g3","L3000-49","in 10mM DMSO","E3 ligase Ligand","Others","CC-99282 (Golcadomide) is an orally active cereblon (CRBN)  E3 ligase  modulator (CELMoD). Ikaros and Aiolos are degraded potently and specifically by CC-99282, which co-opts CRBN.",535.57,"2379572-34-4",{"v":100,"d":"100.00"},186.72,"<1","N/A","http://www.selleckchem.com/products/cc-99282.html","C28H30FN5O5","Free base","Golcadomide","FC1=C(CNC2=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=CC(=C1)CN5CC(C5)N6CCOCC6",1.442,5,2,7]
["E1245","Ro5-3335","h3","L3000-49","in 10mM DMSO","Others","Others","Ro5-3335 is an inhibitor of Core binding factor leukemia (CBF leukemia), by interacting with RUNX1 and CBFβ directly, repressing RUNX1/CBFB-dependent transactivation and runx1-dependent hematopoiesis.",259.69,"30195-30-3",{"v":52,"d":"52.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/ro5-3335.html","C13H10ClN3O","Free base","N/A","ClC1=CC=C2NC(=O)CN=C(C3=CC=C[NH]3)C2=C1",{"v":2.35,"d":"2.350"},2,2,1]
["E1275","FR054","a4","L3000-49","in 10mM DMSO","Others","Others","FR054 is a novel inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3 with a remarkable anti-breast cancer effect.",{"v":329.3,"d":"329.30"},"35954-65-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/fr054.html","C14H19NO8","Free base","N/A","CC(=O)OCC1OC2OC(=NC2C(OC(C)=O)C1OC(C)=O)C",-0.379,9,0,7]
["E2375","PI3K/mTOR Inhibitor-2","b4","L3000-49","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with antitumor activity.",478.86,"1848242-58-9",{"v":96,"d":"96.00"},200.48,"<1","N/A","https://www.selleckchem.com/products/pi3k-mtor-inhibitor-2.html","C20H13ClF2N4O4S","Free base","N/A","COC1=NC=C(C=C1N[S;v6](=O)(=O)C2=C(F)C=C(F)C=C2)C3=CN4C(=O)C(=CN=C4C=C3)Cl",1.879,6,1,5]
["E2397","hVEGF-IN-1","c4","L3000-49","in 10mM DMSO","VEGFR","Angiogenesis","hVEGF-IN-1, a quinazoline derivative, specifically binds to the G-rich sequence in the internal ribosome entry site A (IRES-A) with a Kd of 0.928 μM, therefore destabilizes the G-quadruplex structure, , also hinders tumor cells migration and represses tumor growth by decreasing VEGF-A protein expression.",581.75,"1637443-98-1",{"v":25,"d":"25.00"},42.97,"<1","N/A","http://www.selleckchem.com/products/hvegf-in-1.html","C34H43N7O2","Free base","N/A","CCN(CC)CCOC1=CC=C(NC2=NC(=NC3=C2C=CC=C3)C4=C(NC(=O)CCN5CCN(C)CC5)C=CC=C4)C=C1",5.249,4,2,13]
["E2398","STAT5-IN-2","d4","L3000-49","in 10mM DMSO","STAT","JAK/STAT","STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.",397.51,"2111834-61-6",{"v":80,"d":"80.00"},201.25,"<1","N/A","http://www.selleckchem.com/products/stat5-in-2.html","C26H27N3O","Free base","N/A","CC1(C)CCN(CCOC2=CC3=C([NH]C=C3)C=C2)C4=C1C=C(C=C4)C5=CN=CC=C5",5.274,2,1,5]
["E2399","Falnidamol","e4","L3000-49","in 10mM DMSO","EGFR,p38 MAPK","Protein Tyrosine Kinase","Falnidamol (BIBX1382) is a selective inhibitor of epidermal growth factor receptor (EGFR), exerting anti-cancer role in human head and neck squamous cell carcinomas both in vitro and in vivo through suppressing mitogen-activated protein kinases (MAPKs) signaling.",387.84,"196612-93-8",{"v":20,"d":"20.00"},51.57,"<1","N/A","http://www.selleckchem.com/products/falnidamol.html","C18H19ClFN7","Free base","BIBX1382","CN1CCC(CC1)NC2=NC=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=N2",3.437,4,2,4]
["E2404","NVP-LCQ195","f4","L3000-49","in 10mM DMSO","CDK","Cell Cycle","NVP-LCQ195 (AT9311, LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.",460.34,"902156-99-4",{"v":92,"d":"92.00"},199.85,"<1","N/A","https://www.selleckchem.com/products/nvp-lcq195.html","C17H19Cl2N5O4S","Free base","LCQ-195, AT9311","C[S;v6](=O)(=O)N1CCC(CC1)NC(=O)C2=N[NH]C=C2NC(=O)C3=C(Cl)C=CC=C3Cl",1.185,5,3,5]
["E2438","Ginsenoside Rg3","g4","L3000-49","in 10mM DMSO","Others","Others","Ginsenoside Rg3 is a ginsenoside found in Panax japonicus var. and Panax ginseng, mainly used for the study of tumor diseases.",{"v":785,"d":"785.00"},"11019-45-7",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleckchem.com/products/ginsenoside-rg3.html","C42H72O13","Free base","N/A","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["E2629","Vimseltinib","h4","L3000-49","in 10mM DMSO","c-Kit,CSF-1R","Protein Tyrosine Kinase","Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.",431.49,"1628606-05-2",{"v":86,"d":"86.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/vimseltinib.html","C23H25N7O2","Free base","DCC-3014","CC(C)NC1=NC=C(C(=O)N1C)C2=CC=C(OC3=CC=NC(=C3)C4=C[N](C)N=C4)C(=N2)C",2.226,6,1,6]
["E2656","R1530","a5","L3000-49","in 10mM DMSO","FGFR,VEGFR","Angiogenesis","R1530 is a highly potent, orally bioavailable, dual-acting mitosis/angiogenesis inhibitor for the treatment of solid tumors, which can inhibit vascular endothelial growth factor receptor 2 (VEGFR2) and fibroblast growth factor receptors 1 (FGFR1) with IC50s of 10 nM and 28 nM, respectively.",356.78,"882531-87-5",{"v":71,"d":"71.00"},{"v":199,"d":"199.00"},"<1","N/A","http://www.selleckchem.com/products/r1530.html","C18H14ClFN4O","Free base","N/A","COC1=C(F)C=C2C(=C1)N=C3NNC(=C3N=C2C4=CC=CC=C4Cl)C",3.036,3,2,2]
["E2658","FN-1501","b5","L3000-49","in 10mM DMSO","CDK,FLT3","Cell Cycle","FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively.",431.49,"1429515-59-2",{"v":86,"d":"86.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/fn-1501.html","C22H25N9O","Free base","N/A","CN1CCN(CC1)CC2=CC=C(NC(=O)C3=N[NH]C=C3NC4=C5C=C[NH]C5=NC=N4)C=C2",2.321,4,4,6]
["E2821","RGB-286638 free base","c5","L3000-49","in 10mM DMSO","CDK,GSK-3,JAK,MEK,TAK1","Cell Cycle","RGB-286638 free base is a Cyclin-dependent kinase (CDK) inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.",545.63,"784210-88-4",{"v":100,"d":"100.00"},183.27,"<1","N/A","http://www.selleckchem.com/products/rgb-286638-free-base.html","C29H35N7O4","Free base","N/A","COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=N[NH]C4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6",2.022,5,3,8]
["P1005","Abarelix Acetate","d5","L3000-49","in 10mM DMSO","Others","Endocrinology & Hormones","Abarelix Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.",1476.12,"785804-17-3",{"v":100,"d":"100.00"},67.75,{"v":100,"d":"100.00"},67.75,"http://www.selleckchem.com/peptide/abarelix-acetate.html","C74H99ClN14O16","Acetate","Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(ipr)-Pro-D-Ala-NH2","CC(C)CC(NC(=O)C(CC(N)=O)NC(=O)C(CC1=CC=C(O)C=C1)N(C)C(=O)C(CO)NC(=O)C(CC2=CN=CC=C2)NC(=O)C(CC3=CC=C(Cl)C=C3)NC(=O)C(CC4=CC5=C(C=CC=C5)C=C4)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N6CCCC6C(=O)NC(C)C(N)=O.CC(O)=O",-0.464,14,13,38]
["P1144","Antide","e5","L3000-49","in 10mM DMSO","Apoptosis related,GNRH Receptor","Endocrinology & Hormones","Antide(Iturelix), a gonadotropin-releasing hormone (GNRH) antagonist, inhibits apoptosis of preovulatory follicle cells in the rat ovary.",{"v":1591.3,"d":"1591.30"},"112568-12-4",{"v":100,"d":"100.00"},62.84,{"v":50,"d":"50.00"},31.42,"http://www.selleckchem.com/products/antide.html","C82H108ClN17O14","Free base","Iturelix","CC(C)CC(NC(=O)C(CCCCNC(=O)C1=CN=CC=C1)NC(=O)C(CCCCNC(=O)C2=CN=CC=C2)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(Cl)C=C4)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N7CCCC7C(=O)NC(C)C(N)=O",{"v":2.35,"d":"2.350"},16,14,46]
["E0444","LDC203974 (IMT1B)","f5","L3000-49","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","LDC203974 (IMT1B) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. LDC203974 has anti-tumour effects.",473.88,"2304621-06-3",{"v":95,"d":"95.00"},200.47,"<1","N/A","https://www.selleckchem.com/products/ldc203974-imt1b.html","C24H21ClFNO6","free base","IMT1B","CC(OC1=CC=C2C(=C1)OC(=O)C=C2C3=C(Cl)C=C(F)C=C3)C(=O)N4CCCC(C4)C(O)=O",4.218,5,0,5]
["E1221","CIA1","g5","L3000-49","in 10mM DMSO","Others","Others","CIA 1 (COUP-TFII inhibitor A1) is a specific inhibitor of the nuclear receptor COUP-TFII with IC50 of 1.2 μM to 7.6 μM in prostate cancer cell lines.",365.88,"1049691-47-5",{"v":73,"d":"73.00"},199.52,"<1","N/A","https://www.selleckchem.com/products/cia1.html","C17H19N3O2S.ClH","Chloride","COUP-TFII inhibitor A1","Cl.COC1=C(OC)C=C(CCNC2=C3C=C(C)SC3=NC=N2)C=C1",3.859,4,1,6]
["E1267","MDL-800","h5","L3000-49","in 10mM DMSO","Sirtuin","Epigenetics","MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM.",{"v":626.3,"d":"626.30"},"2275619-53-7",{"v":100,"d":"100.00"},159.67,"<1","N/A","https://www.selleckchem.com/products/mdl-800.html","C21H16BrCl2FN2O6S2","chloride","N/A","COC(=O)C1=C(C=CC(=C1)N[S](=O)(=O)C2=CC(=CC(=C2)Cl)Cl)[S](=O)(=O)NC3=C(C)C=C(F)C(=C3)Br",5.429,6,2,8]
["E1297","BGB 15025","a6","L3000-49","in 10mM DMSO","MAP4K","MAPK","BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.",536.64,"2766481-17-6",{"v":100,"d":"100.00"},186.34,"<1","N/A","https://www.selleckchem.com/products/bgb-15025.html","C28H37FN8O2","free base","N/A","CN1CCC(CC1)[N]2C=C(OC3=C(N)N=CC(=N3)C4=CC(=C(C(=C4)C)C(=O)NCCN5CCC(F)C5)C)C=N2",2.757,5,2,8]
["E1305","RBN013209","b6","L3000-49","in 10mM DMSO","CD markers","Transmembrane Transporters","RBN013209 is a potent inhibitor of CD38 with an IC50 of 0.01-0.1 μM for human CD38. It can be used for the research of cancer.",384.43,"2597933-17-8",{"v":19,"d":"19.00"},49.42,"<1","N/A","https://www.selleckchem.com/products/rbn013209.html","C19H24N6O3","free base","N/A","COCCOC1CCC(CC1)NC(=O)C2=C3[NH]C=CC3=NC(=N2)[N]4C=CN=C4",1.499,6,2,7]
["E1322","GS-4224","c6","L3000-49","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.",691.61,"2374856-75-2",{"v":100,"d":"100.00"},144.59,"<1","N/A","https://www.selleckchem.com/products/gs-4224.html","C34H36Cl2N8O4","free base","Evixapodlin, PD-1/PD-L1-IN 7","COC1=C(CNCC2CCC(=O)N2)N=CC(=N1)C3=CC=CC(=C3Cl)C4=C(Cl)C(=CC=C4)C5=NC(=C(CNCC6CCC(=O)N6)N=C5)OC",3.472,8,4,13]
["E1328","TP-1454","d6","L3000-49","in 10mM DMSO","PKM","Metabolism","TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.",462.46,"2490276-04-3",{"v":92,"d":"92.00"},198.94,"<1","N/A","https://www.selleckchem.com/products/tp-1454.html","C19H22F4N4O3S","free base","N/A","NC1=CC=CC(=C1CN(CCC2CC[S](=O)(=O)CC2)C(=O)C3=CC(=N[NH]3)C(F)(F)F)F",2.929,4,2,7]
["E1329","K-975","e6","L3000-49","in 10mM DMSO","TEAD","Hippo","K-975 is a potent, selective and orally active TEAD inhibitor that directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma.",287.74,"2563855-03-6",{"v":58,"d":"58.00"},201.57,"<1","N/A","https://www.selleckchem.com/products/k-975.html","C16H14CINO2","free base","N/A","CC1=CC=C(NC(=O)C=C)C=C1OC2=CC=C(Cl)C=C2",4.358,2,1,4]
["E1330","Usp22i-S02","f6","L3000-49","in 10mM DMSO","DUB","Ubiquitin","Usp22i-S02(USP22-IN-1, compound S02) is a potent inhibitor of ubiquitin specific peptidase 22 (USP22). It showed anticancer activity by suppressing Foxp3 expression in T-regulatory cells.",338.41,"309735-96-4",{"v":68,"d":"68.00"},200.94,"<1","N/A","https://www.selleckchem.com/products/usp22i-s02.html","C22H18N4","free base","USP22-IN-1, compound S02","N#CC1=C2CCCCC2=C(NC3=CC=CC=C3)[N]4C5=CC=CC=C5N=C14",5.817,1,1,2]
["E1388","ISA-2011B","g6","L3000-49","in 10mM DMSO","Others","PI3K/Akt/mTOR","ISA-2011B is an inhibitor of phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα). ISA-2011B exhibits anti-proliferative activity and induces apoptosis in prostate cancer cells.",423.85,"1395347-24-6",{"v":85,"d":"85.00"},200.54,"<1","N/A","https://www.selleckchem.com/products/isa-2011b.html","C22H18ClN3O4","free base","N/A","CN1CC(=O)N2C(CC3=CC4=C(OCO4)C=C3C2C5=C[NH]C6=CC=C(Cl)C=C56)C1=O",2.663,4,1,1]
["E1411","Tuvusertib","h6","L3000-49","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines.",370.32,"1613200-51-3",{"v":12,"d":"12.00"},{"v":32.4,"d":"32.40"},"<1","N/A","https://www.selleckchem.com/products/tuvusertib.html","C16H12F2N8O","free base","M1774, ATR inhibitor 1","C[N]1C=NC=C1C2=C(F)C=NC=C2NC(=O)C3=C4N=CC(=C[N]4N=C3N)F",-0.157,5,2,3]
["E1421","A2ti-1","a7","L3000-49","in 10mM DMSO","Anti-infection","Microbiology","A2ti-1 is a selective and high-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t) with IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. It also prevents human papillomavirus type 16 (HPV16) infection.",382.48,"570390-00-0",{"v":77,"d":"77.00"},201.32,"<1","N/A","https://www.selleckchem.com/products/a2ti-1.html","C20H22N4O2S","free base","N/A","CCC1=C(C=CC=C1)[N]2C(=NN=C2SCC(N)=O)COC3=C(C)C=CC=C3",4.102,4,1,8]
["E1425","Nesuparib","b7","L3000-49","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Nesuparib (JPI-547, NOV140201) is a potential inhibitor of both PARP and tankyrases, with IC50 of 0.005 μM, 0.001 μM, 0.002 μM, and ND for TNKS1, TNKS2, PARP1, and PARP2, respectively. Nesuparib exhibits anti-tumor activity in BRCA-deficient xenograft models.",400.48,"2055357-64-5",{"v":26,"d":"26.00"},64.92,"<1","N/A","https://www.selleckchem.com/products/nesuparib.html","C23H24N6O","free base","JPI-547, NOV140201","O=C1NC2=CC(=CC=C2C3=C1CCCN3)CN4CCN(CC4)C5=CC=C(C=N5)C#N",1.949,2,2,3]
["E1427","MRT-2359","c7","L3000-49","in 10mM DMSO","E3 Ligase","Ubiquitin","MRT-2359 is a potent degrader of GSPT1. It exhibits anti-tumor activity in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.",495.38,"2803881-11-8",{"v":100,"d":"100.00"},201.87,"<1","N/A","https://www.selleckchem.com/products/mrt-2359.html","C22H17F4N3O6","free base","N/A","FC1=CC=C(OC(F)(F)F)C=C1NC(=O)OCC2=CC=C3CN(C4CCC(=O)NC4=O)C(=O)C3=C2",3.904,6,2,7]
["E1428","Mps1-IN-6 (Compound 9)","d7","L3000-49","in 10mM DMSO","Mps1","Cytoskeletal Signaling","Mps1-IN-6 (Compound 9)  is a potent Mps1 inhibitor with IC50 of 6.4 nM. It also exhibits antiproliferative and anti-tumor activity in breast cancer cells.",445.52,"2489220-49-5",{"v":30,"d":"30.00"},67.34,"<1","N/A","https://www.selleckchem.com/products/mps1-in-6-compound-9-.html","C24H27N7O2","free base","N/A","COC1=C(NC2=NC(=C3C(=N2)[NH]C=C3C#N)NC4CCCCC4)C=CC(=C1)N5CCCC5=O",4.265,4,3,6]
["E1429","T1-44","e7","L3000-49","in 10mM DMSO","PRMT","Epigenetics","T1-44 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It exhibits anti-tumor activity in pancreatic cancers.",478.63,"N/A",{"v":96,"d":"96.00"},200.57,"<1","N/A","https://www.selleckchem.com/products/t1-44.html","N/A","free base","N/A","CN1CCN(CC1)C2=NC(=CC(=C2)C(=O)NCC(O)CN3CCC4=C(C3)C=CC=C4)NC5CCC5",3.125,2,3,8]
["E1436","A2ti-2","f7","L3000-49","in 10mM DMSO","Anti-infection","Microbiology","A2ti-2 is a selective and low-affinity inhibitor of annexin A2/S100A10 heterotetramer (A2t)with an IC50 of 230 μM. It specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10 and also prevents human papillomavirus type 16 (HPV16) infection.",354.43,"482646-13-9",{"v":71,"d":"71.00"},200.32,"<1","N/A","https://www.selleckchem.com/products/a2ti-2.html","C18H18N4O2S","free base","N/A","CC1=C(OCC2=NN=C(SCC(N)=O)[N]2C3=CC=CC=C3)C=CC=C1",{"v":3.16,"d":"3.160"},4,1,7]
["E1468","MSU-42011","g7","L3000-49","in 10mM DMSO","Retinoid Receptor","Metabolism","MSU-42011 is an orally active agonist of retinoid X receptor (RXR). MSU-42011 inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research.",382.54,"2456434-36-7",{"v":38,"d":"38.00"},99.34,"<1","N/A","https://www.selleckchem.com/products/msu-42011.html","C24H34N2O2","free base","N/A","CC(C)CN(C1=CC(=CC(=C1)C(C)(C)C)C(C)(C)C)C2=CC=C(C=N2)C(O)=O",6.596,2,0,7]
["E1485","IDE397 (GSK-4362676)","h7","L3000-49","in 10mM DMSO","MAT2A","Methylation","IDE397 (GSK-4362676) is a potent inhibitor of  MAT2A(methionine adenosyltransferase 2A) and exhibits anti-tumor activity in MTAP-deleted PDX models.",340.69,"2439277-80-0",{"v":23,"d":"23.00"},67.51,"<1","N/A","https://www.selleckchem.com/products/ide397-gsk-4362676.html","C14H8ClF3N4O","free base","N/A","NC1=NC(=O)N(C2=C(Cl)C=CC=C2)C3=NC(=CC=C13)C(F)(F)F",3.825,3,1,2]
["E1502","Deutenzalutamide","a8","L3000-49","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Deutenzalutamide (HC-1119, MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. It can be used in a treatment of advanced prostate cancer.",467.46,"1443331-82-5",{"v":93,"d":"93.00"},198.95,"<1","N/A","https://www.selleckchem.com/products/deutenzalutamide.html","C21H13D3F4N4O2S","free base","HC-1119, MDV3100","C(NC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC(=C(C=C3)C#N)C(F)(F)F)([2H])([2H])[2H]",4.954,2,1,5]
["E2430","Allocholic acid","b8","L3000-49","in 10mM DMSO","Others","Others","Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. Allocholic acid is also a potent and specific stimulant of the adult olfactory system.",408.57,"2464-18-8",{"v":82,"d":"82.00"},{"v":200.7,"d":"200.70"},{"v":-1,"d":"-1.00"},-2.45,"https://www.selleckchem.com/products/allocholic-acid.html","C24H40O5","free base","N/A","CC(CCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",2.912,1,3,4]
["E2862","(+/-)-Naringenin","c8","L3000-49","in 10mM DMSO","Others","Others","(±)-Naringenin, a natural flavonoid present in citrus fruits, induces apoptosis and cytotoxicity in cancer cells.",272.25,"93602-28-9",{"v":54,"d":"54.00"},198.35,"<1","N/A","https://www.selleckchem.com/products/------naringenin.html","C15H12O5","free base","N/A","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["E2880","methylnaltrexone bromide","d8","L3000-49","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Methylnaltrexone bromide is an antagonist of µ-opioid receptor that reduces the viability of lung cancer cells by inhibiting Src activation.",436.34,"73232-52-7",{"v":100,"d":"100.00"},229.18,{"v":100,"d":"100.00"},229.18,"https://www.selleckchem.com/products/methylnaltrexone-bromide.html","C21H26NO4.Br","bromide","N/A","[Br-].C[N+]1(CCC23C4OC5=C(O)C=CC(=C25)CC1C3(O)CCC4=O)CC6CC6",-2.116,2,1,2]
["E2910","bisBenzimide H 33258 Trihydrochloride","e8","L3000-49","in 10mM DMSO","Others","Others","bisBenzimide H 33258 Trihydrochloride(Hoechst 33258 trihydrochloride; H 33258 trihydrochloride) is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. It binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity. Therefore, Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution. It exhibits anti-tumor activity IC50 of 51.31±4.56 μM in HeLa cells.",533.88,"23491-45-4",{"v":31,"d":"31.00"},58.07,{"v":23,"d":"23.00"},43.08,"https://www.selleckchem.com/products/bisbenzimide-h-33258.html","C25H24N6O.3ClH","Trihydrochloride","Hoechst 33258 trihydrochloride; H 33258 trihydrochloride","Cl.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=CC=C5N=C([NH]C5=C4)C6=CC=C(O)C=C6",{"v":4.97,"d":"4.970"},2,3,3]
["E2914","5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside","f8","L3000-49","in 10mM DMSO","Casein Kinase","Metabolism","5,6-Dichlorobenzimidazole riboside(DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. It trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.",319.14,"53-85-0",{"v":64,"d":"64.00"},200.54,"<1","N/A","https://www.selleckchem.com/products/5-6-dichlorobenzimidazole-1-beta-d-ribofuranoside.html","C12H12Cl2N2O4","dichloride","DRB","OCC1OC(C(O)C1O)[N]2C=NC3=CC(=C(Cl)C=C23)Cl",1.235,2,3,2]
["E2932","SI-2 Hydrochloride","g8","L3000-49","in 10mM DMSO","Others","Neuronal Signaling","SI-2 hydrochloride (EPH 116 hydrochloride) is an inhibitor of Steroid receptor coactivator 3 (SRC-3), with IC50 of 3–20 nM, it can significantly inhibit breast tumor growth.",301.77,"1992052-49-9",{"v":20,"d":"20.00"},66.28,{"v":8,"d":"8.00"},26.51,"https://www.selleckchem.com/products/si-2-hydrochloride.html","C15H15N5.ClH","hydrochloride","EPH 116 Hydrochloride","Cl.C[N]1C(=NC2=CC=CC=C12)NN=C(C)C3=CC=CC=N3",3.352,3,1,3]
["E2933","MOMIPP","h8","L3000-49","in 10mM DMSO","PIKfyve","PI3K/Akt/mTOR","MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.",292.33,"1363421-46-8",{"v":15,"d":"15.00"},51.31,"<1","N/A","https://www.selleckchem.com/products/momipp.html","C18H16N2O2","free base","N/A","COC1=CC=C2[NH]C(=C(\\C=C\\C(=O)C3=CC=NC=C3)C2=C1)C",2.974,3,1,4]
["E2939","Didox","a9","L3000-49","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","Didox (3,4-dihydroxy-benzohydroxamic acid)  is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells.",169.14,"69839-83-4",{"v":34,"d":"34.00"},201.02,{"v":34,"d":"34.00"},201.02,"https://www.selleckchem.com/products/didox.html","C7H7NO4","free base","3,4-dihydroxy-benzohydroxamic acid","ONC(=O)C1=CC(=C(O)C=C1)O",{"v":0.36,"d":"0.360"},1,3,1]
["E2943","Pifithrin-β","b9","L3000-49","in 10mM DMSO","p53","Apoptosis","Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.",268.38,"60477-34-1",{"v":27,"d":"27.00"},{"v":100.6,"d":"100.60"},"<1","N/A","https://www.selleckchem.com/products/pifithrin-beta.html","C16H16N2S","free base","PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide","CC1=CC=C(C=C1)C2=C[N]3C4=C(CCCC4)SC3=N2",4.125,1,0,1]
["E2954","Ethyl methanesulfonate","c9","L3000-49","in 10mM DMSO","Others","Others","Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. It induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes.",124.16,"62-50-0",{"v":25,"d":"25.00"},201.35,{"v":25,"d":"25.00"},201.35,"https://www.selleckchem.com/products/ethyl-methanesulfonate.html","C3H8O3S","free base","N/A","CCO[S](C)(=O)=O",-0.026,1,0,2]
["E4010","L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride","d9","L3000-49","in 10mM DMSO","Others","Others","L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride(Melevodopa hydrochloride) is a precursor to L-DOPA. It is an antiparkinsonian agent L-DOPA methyl ester that  elicits antitumor functionality in leukemia and melanoma.",247.68,"1421-65-4",{"v":50,"d":"50.00"},201.87,{"v":50,"d":"50.00"},201.87,"https://www.selleckchem.com/products/l-3,4-dihydroxyphenylalanine-methyl-ester-hydrochloride.html","C10H13NO4.ClH","hydrochloride","Melevodopa hydrochloride","Cl.COC(=O)C(N)CC1=CC(=C(O)C=C1)O",0.997,2,3,4]
["E4030","N-p-Tosyl-L-phenylalanine chloromethyl ketone","e9","L3000-49","in 10mM DMSO","Others","Proteases","N-p-Tosyl-L-phenylalanine chloromethyl ketone (Tosyl phenylalanyl chloromethyl ketone, TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis.",351.85,"402-71-1",{"v":70,"d":"70.00"},198.95,"<1","N/A","https://www.selleckchem.com/products/n-p-tosyl-l-phenylalanine-chloromethyl-ketone.html","C17H18ClNO3S","chloride","Tosyl phenylalanyl chloromethyl ketone, TPCK","CC1=CC=C(C=C1)[S](=O)(=O)NC(CC2=CC=CC=C2)C(=O)CCl",3.381,3,1,7]
["S0984","KCC-07","f9","L3000-49","in 10mM DMSO","Others","Epigenetics","KCC-07 is a potent, selective and brain-penetrant inhibitor of MBD2 (methyl-CpG-binding domain protein 2) with anticancer activity. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.",269.32,"315702-75-1",{"v":54,"d":"54.00"},{"v":200.5,"d":"200.50"},"<1","N/A","https://www.selleckchem.com/products/kcc-07.html","C14H11N3OS","free base","N/A","OC1=CC=CC(=C1)NC2=NC(=CS2)C3=CC=CC=N3",{"v":3.36,"d":"3.360"},2,2,3]
["S3493","APS6-45","g9","L3000-49","in 10mM DMSO","RAS","MAPK","APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.",548.39,"2188236-41-9",{"v":100,"d":"100.00"},182.35,"<1","N/A","https://www.selleckchem.com/products/aps6-45.html","C23H16F8N4O3","free base","N/A","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=C(F)C=CC(=C3)C(F)(C(F)(F)F)C(F)(F)F)C=C2",5.009,4,3,8]
["S8473","CA-170 (AUPM-170)","h9","L3000-49","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and  VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.",360.32,"1673534-76-3",{"v":72,"d":"72.00"},199.82,"<1","N/A","https://www.selleckchem.com/products/ca-170.html","C12H20N6O7","amine","AUPM-170, PD-1-IN-1","CC(O)C(NC(=O)NC(CC(N)=O)C1=NC(=NO1)C(N)CO)C(O)=O",{"v":-6.28,"d":"-6.280"},6,6,9]
["E1217","PCLX-001 (DDD86481)","a10","L3000-49","in 10mM DMSO","Others","Others","PCLX-001 (DDD86481) is an orally active dual N-myristoyltransferase (NMT) inhibitor. It inhibits NMT1 and NMT2 with IC50 of 5 nM and 8 nM, respectively, in vitro. PCLX-001 inhibits early B-cell receptor (BCR) signalling, which can be used in B-cell malignancy research.",537.51,"1215011-08-7",{"v":13,"d":"13.00"},24.19,"<1","N/A","https://www.selleckchem.com/products/pclx-001-ddd86481.html","C24H30Cl2N6O2S","free base","DDD86481","CC(C)CC1=N[N](C)C(=C1N[S](=O)(=O)C2=C(Cl)C=C(C=C2Cl)C3=CC=NC(=C3)N4CCNCC4)C",4.589,4,2,7]
["E1478","BDTX-1535","b10","L3000-49","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","BDTX-1535 (EGFR-IN-76) is an orally available, highly potent, selective, and irreversible EGFR inhibitor that can penetrate the blood-brain barrier, with the potential to treat Glioblastoma or Non-Small Cell Lung Cancer.",561.05,"2607829-38-7",{"v":100,"d":"100.00"},178.24,"<1","N/A","https://www.selleckchem.com/products/bdtx-1535.html","C30H30ClFN6O2","free base","EGFR-IN-76","CN1CC2CC2(C1)C#CC3=CC4=C(C=C3NC(=O)\\C=C\\CN5CCOCC5)C(=NC=N4)NC6=C(F)C(=CC=C6)Cl",{"v":4.5,"d":"4.500"},4,2,8]
["E1480","DJ4","c10","L3000-49","in 10mM DMSO","ROCK","Cell Cycle","DJ4 (EX-A7863) is a potent, selective ATP-competitive inhibitor of ROCK1/2 and MRCKα/β with IC50 of 5/50 nM and 10/100 nM respectively. It blocks stress fiber formation and inhibits migration and invasion of multiple cancer cell line",350.44,"N/A",{"v":10,"d":"10.00"},28.54,"<1","N/A","https://www.selleckchem.com/products/dj4.html","N/A","free base","EX-A7863","O=C\\1NC(SC1=C/C2=CNC3N=CC=CC23)=NCCC4=CC=CC=C4",2.198,3,2,4]
["E1512","M3541","d10","L3000-49","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","M3541 is a potent and selective inhibitor of ATM kinase activity with an IC50 value of 0.25 nM in cell-free assays. M3541 suppresses double-strand breaks (DSB) repair, clonogenic cancer cell growth and potentiates antitumor activity of ionizing radiation in cancer cell lines.",428.42,"1360628-91-6",{"v":11,"d":"11.00"},25.68,"<1","N/A","https://www.selleckchem.com/products/m3541.html","C23H17FN6O2","free base","N/A","COC1=C(C=C2C(=C1)N=CC3=C2N(C(=O)N3C)C4=C(F)C=C(C=C4)C#N)C5=C[N](C)N=C5",3.103,4,0,3]
["E1538","PRGL493","e10","L3000-49","in 10mM DMSO","Others","Others","PRGL493 is a potent and selective inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research.",451.48,"2479378-45-3",{"v":8,"d":"8.00"},17.72,"<1","N/A","https://www.selleckchem.com/products/prgl493.html","C25H21N7O2","free base","N/A","CC(=O)NC1=NC(N2C(=N1)NC3=CC=CC=C23)C4=C[N](N=C4C5=CC=C(C)O5)C6=CC=CC=C6",4.299,5,2,4]
["E1549","AZD0095","f10","L3000-49","in 10mM DMSO","MCT","Transmembrane Transporters","AZD0095 is a selective and orally active Monocarboxylate transporter 4 (MCT4) inhibitor with IC50 of 1.3 nM and effectively inhibits the tumor growth in NCI-H358 xenografts in combination with Cediranib.",{"v":500.6,"d":"500.60"},"2750001-23-9",{"v":13,"d":"13.00"},25.97,"<1","N/A","https://www.selleckchem.com/products/azd0095.html","C27H32N8O2","free base","N/A","CC1=N[N]2C(=C(OC3CCN(C3)C4=CC=C(C=C4)C5=CC=C(CN6CCOCC6)N=N5)C(=NC2=N1)C)C",2.771,7,0,6]
["E1574","FSEN1","g10","L3000-49","in 10mM DMSO","Ferroptosis","Apoptosis","FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. It triggers iron death in cancer cells by inhibiting FSP1 and can be used in research of cancer.",484.41,"862808-01-3",{"v":8,"d":"8.00"},16.51,"<1","N/A","https://www.selleckchem.com/products/fsen1.html","C22H22BrN5OS","free base","N/A","COC1=CC=C(C=C1)N2CCN(CC2)CC3=C[N]4C(=NN=C4C5=CC=C(Br)C=C5)S3",4.489,3,0,5]
["E1578","garsorasib (D-1553 )","h10","L3000-49","in 10mM DMSO","Ras","GPCR & G Protein","Garsorasib (D-1553 ) is a potent and selective oral KRAS<sup>G12C</sup> inhibitor with antitumor activity. It has the potential to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC).",598.65,"2559761-14-5",{"v":100,"d":"100.00"},167.04,"<1","N/A","https://www.selleckchem.com/products/d-1553.html","C32H32F2N8O2","free base","N/A","CC1CN(C(C)CN1C(=O)C=C)C2=NC(=O)N(C3=NC(=C(F)C=C23)C4=C(F)C=CC=C4N)C5=C(N=CN=C5C6CC6)C7CC7",4.785,6,1,6]
["E1596","AOH1996","a11","L3000-49","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.",426.46,"2089314-64-5",{"v":85,"d":"85.00"},199.32,"<1","N/A","https://www.selleckchem.com/products/aoh1996.html","C26H22N2O4","free base","N/A","COC1=CC=CC(=C1)OC2=C(NC(=O)CNC(=O)C3=CC=CC4=C3C=CC=C4)C=CC=C2",4.126,4,2,7]
["E1598","VT103","b11","L3000-49","in 10mM DMSO","TEAD","Hippo","VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation with anti-proliferative and anti-tumor activity. It also inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation and disrupts interaction between YAP/TAZ and TEAD.",410.42,"2290608-13-6",{"v":82,"d":"82.00"},{"v":199.8,"d":"199.80"},"<1","N/A","https://www.selleckchem.com/products/vt103.html","C18H17F3N4O2S","free base","N/A","CN[S](=O)(=O)C1=CC(=C(NC2=CC=C(C=C2)C(F)(F)F)C=C1)C3=C[N](C)C=N3",3.273,3,2,6]
["E1603","ACT001(DMAMCL)","c11","L3000-49","in 10mM DMSO","PAI-1","Metabolism","ACT001(DMAMCL, dimethylaminomicheliolide) is a PAI-1 inhibitor and exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo. It also exerts synergistic effects in combination with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway.",{"v":293.4,"d":"293.40"},"1403357-81-2",{"v":59,"d":"59.00"},201.09,{"v":59,"d":"59.00"},201.09,"https://www.selleckchem.com/products/act001-dmamcl.html","C17H27NO3","free base","DMAMCL, dimethylaminomicheliolide","CN(C)CC1C2CCC(=C3CCC(C)(O)C3C2OC1=O)C",1.913,2,0,2]
["E1605","Avotaciclib trihydrochloride","d11","L3000-49","in 10mM DMSO","CDK","Cell Cycle","Avotaciclib trihydrochloride(BEY1107 trihydrochloride) is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). It can be used for the research of locally advanced or metastatic pancreatic cancer.",390.66,"1983984-01-5",{"v":4,"d":"4.00"},10.24,{"v":78,"d":"78.00"},199.66,"https://www.selleckchem.com/products/avotaciclib-trihydrochloride.html","C13H11N7O.3ClH","Trihydrochloride","BEY1107 trihydrochloride","Cl.NC1=NC=CC(=N1)C2=NC(=C(O)C=C2)C3=NC(=NC=C3)N",1.561,5,3,2]
["E1649","Exarafenib","e11","L3000-49","in 10mM DMSO","Raf","MAPK","Exarafenib(KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.",521.58,"2639957-39-2",{"v":100,"d":"100.00"},191.73,"<1","N/A","https://www.selleckchem.com/products/exarafenib.html","C26H34F3N5O3","free base","KIN-002787, KIN-2787, RAF/KIN_2787","CC(CO)NC1=NC(=CC(=C1)C2=CC(=CC=C2C)NC(=O)N3CCC(C3)CC(F)(F)F)N4CCOCC4",4.073,3,3,8]
["E1650","Opevesostat (ODM208)","f11","L3000-49","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Opevesostat (ODM208) is the first-in-class, selective, nonsteroidal, oral CYP11A1 inhibitor. ODM208 exhibits a rapid, complete, durable, and reversible inhibition of the steroid hormone biosynthesis in an adrenocortical carcinoma cell model in vitro, in adult noncastrated male mice and dogs, and in patients with CRPC.",418.51,"2231294-96-3",{"v":7,"d":"7.00"},16.73,"<1","N/A","https://www.selleckchem.com/products/odm208.html","C21H26N2O5S","free base","N/A","C[S](=O)(=O)N1CCC(CC1)COC2=COC(=CC2=O)CN3CC4=CC=CC=C4C3",0.869,5,0,6]
["E1651","CD532","g11","L3000-49","in 10mM DMSO","Aurora Kinase","Epigenetics","CD532 is a potent  Aurora A kinase inhibitor with an IC50 of 45 nM. It breaks the native conformation of Aurora-A, drives the degradation of  N-Myc in N-Myc-driven cancers, and also exhibits anti-proliferative effects.",522.53,"1639009-81-6",{"v":100,"d":"100.00"},191.38,"<1","N/A","https://www.selleckchem.com/products/cd532.html","C26H25F3N8O","free base","N/A","FC(F)(F)C1=CC=CC(=C1)NC(=O)NC2=CC=C(NC3=NC=CC(=N3)NC4=N[NH]C(=C4)C5CCCC5)C=C2",6.645,4,5,8]
["E1658","PRT543","h11","L3000-49","in 10mM DMSO","PRMT","Epigenetics","PRT543 is a  potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM.",376.79,"1989620-03-2",{"v":75,"d":"75.00"},199.05,"<1","N/A","https://www.selleckchem.com/products/prt543.html","C17H17ClN4O4","free base","N/A","NC1=C2C=C[N](C3OC(C(O)C3O)C(O)C4=CC=C(Cl)C=C4)C2=NC=N1",1.174,3,4,3]
["E1667","LY2880070","a2","L3000-50","in 10mM DMSO","Chk","Cell Cycle","LY2880070 is an orally active inhibitor of CHK1. LY2880070 can be used as an anticancer agent and shows promise in preclinical models of pancreatic ductal adenocarcinoma (PDAC) when used in combination with DNA-damaging agents.",381.43,"1375637-35-6",{"v":76,"d":"76.00"},199.25,"<1","N/A","https://www.selleckchem.com/products/ly2880070.html","C19H23N7O2","free base","N/A","COC1=C(C=CC(=N1)C)C2=CC(=N[NH]2)NC3=NC(=CN=C3)OC4CCCNC4",{"v":2.68,"d":"2.680"},6,3,6]
["E1684","C1632","b2","L3000-50","in 10mM DMSO","Others","Others","C1632 (Lin28-let-7 antagonist 1)  is a RNA-binding protein and a potent antagonist of Lin28/pre-let-7 interaction. It inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM as well as inhibits proliferation in human cancer cells.",281.31,"108825-65-6",{"v":56,"d":"56.00"},199.07,{"v":2,"d":"2.00"},7.11,"https://www.selleckchem.com/products/c1632.html","C15H15N5O","free base","Lin28-let-7 antagonist 1","CN(C(C)=O)C1=CC=CC(=C1)C2=N[N]3C(=NN=C3C=C2)C",1.387,4,0,2]
["E1692","BAY 2965501","c2","L3000-50","in 10mM DMSO","Others","Metabolism","BAY 2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level, and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill.",414.46,"2732902-08-6",{"v":83,"d":"83.00"},200.26,"<1","N/A","https://www.selleckchem.com/products/bay-2965501.html","C20H19FN4O3S","free base","N/A","COC1=CC=C(C=C1)C(=O)C2=C(N)N=C(S2)N(C(C)C(N)=O)C3=CC=C(F)C=C3",3.598,4,2,7]
["E1716","SR9011","d2","L3000-50","in 10mM DMSO","Others","Metabolism","SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi.",479.04,"1379686-29-9",{"v":96,"d":"96.00"},{"v":200.4,"d":"200.40"},"<1","N/A","https://www.selleckchem.com/products/sr9011.html","C23H31ClN4O3S","free base","N/A","CCCCCNC(=O)N1CCC(CN(CC2=CC=C(S2)[N](=O)=O)CC3=CC=C(Cl)C=C3)C1",5.189,1,1,11]
["E1727","Pimicotinib","e2","L3000-50","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","Pimicotinib (ABSK021) is an orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R). It enhances antitumor T-cell immune responses and inhibits the proliferation of tumor cells having potential immunomodulatory and antineoplastic activities.",420.47,"2253123-16-7",{"v":84,"d":"84.00"},199.78,"<1","N/A","https://www.selleckchem.com/products/pimicotinib.html","C22H24N6O3","free base","ABSK021","C[N]1C=C(C=N1)C2=CC(=CC=N2)OC3=C(C)N=C(NC(=O)N4CCC(C)(C)C4=O)C=C3",2.748,6,1,4]
["E1731","JW74","f2","L3000-50","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","JW74 is a specific inhibitor of the canonical Wnt signaling with IC50 790 nM in the ST-Luc assay. It inhibit the growth of tumor cells in both mouse xenograft model of colorectal cancer and in Apc<sup>Min</sup> mice.",456.52,"863405-60-1",{"v":46,"d":"46.00"},100.76,"<1","N/A","https://www.selleckchem.com/products/jw74.html","C24H20N6O2S","free base","N/A","COC1=CC=C(C=C1)[N]2C(=NN=C2C3=CC=NC=C3)SCC4=NC(=NO4)C5=CC=C(C)C=C5",4.471,7,0,7]
["E1732","Itacnosertib (TP-0184)","g2","L3000-50","in 10mM DMSO","ALK","Protein Tyrosine Kinase","Itacnosertib (TP-0184) is a small-molecule inhibitor of the BMP type 1 receptor ALK2 (also known as ACVR1). Itacnosertib reduces hepcidin induction and elevated serum iron levels in turpentine and lung cancer mouse models of ACD.",468.55,"1628870-27-8",{"v":15,"d":"15.00"},32.01,"<1","N/A","https://www.selleckchem.com/products/itacnosertib.html","C26H28N8O","free base","TP-0184","COC1=C(C=CC(=C1)NC2=NC=CC(=N2)NC3=C(N=CC=C3)C4=CC=CC=N4)N5CCN(C)CC5",4.388,5,2,7]
["E1733","PBIT","h2","L3000-50","in 10mM DMSO","Histone Demethylase","Epigenetics","PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. It inhibits JARID1B (KDM5B/PLU1), JARID1Aand JARID1C with an IC50 of 3 μM, 6 μM and 4.9 μM respectively. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1.",241.31,"2514-30-9",{"v":48,"d":"48.00"},198.91,"<1","N/A","https://www.selleckchem.com/products/pbit.html","C14H11NOS","free base","N/A","CC1=CC=C(C=C1)N2SC3=CC=CC=C3C2=O",3.644,1,0,1]
["E1735","PK11007","a3","L3000-50","in 10mM DMSO","p53","Apoptosis","PK11007 is a thiol-reactive anticancer agent that stabilizes  p53  via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant  p53  cancer cell death by increasing reactive oxygen species (ROS) levels.",427.86,"874146-69-7",{"v":86,"d":"86.00"},{"v":201,"d":"201.00"},"<1","N/A","https://www.selleckchem.com/products/pk11007.html","C15H11ClFN5O3S2","free base","N/A","CC1=NN=C(NC(=O)C2=NC(=NC=C2Cl)[S](=O)(=O)CC3=CC=C(F)C=C3)S1",2.499,7,1,5]
["E1739","MST-312","b3","L3000-50","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM).",380.35,"368449-04-1",{"v":76,"d":"76.00"},199.82,"<1","N/A","https://www.selleckchem.com/products/mst-312.html","C20H16N2O6","free base","Telomerase Inhibitor IX","OC1=CC=CC(=C1O)C(=O)NC2=CC(=CC=C2)NC(=O)C3=C(O)C(=CC=C3)O",2.431,2,6,4]
["E1742","Reversan","c3","L3000-50","in 10mM DMSO","P-gp","Transmembrane Transporters","Reversan (CBLC4H10) is a selective and nontoxic inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp), with the potential to treat neuroblastoma and other MRP1-overexpressing drug-refractory tumors.",441.53,"313397-13-6",{"v":18,"d":"18.00"},40.77,"<1","N/A","https://www.selleckchem.com/products/reversan.html","C26H27N5O2","free base","CBLC4H10","O=C(NCCCN1CCOCC1)C2=C3N=C(C=C([N]3N=C2)C4=CC=CC=C4)C5=CC=CC=C5",3.093,4,1,7]
["E1812","N6F11","d3","L3000-50","in 10mM DMSO","Ferroptosis","Apoptosis","N6F11 is an inducer of ferroptosis. N6F11 is bound to the RING domain of the E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of glutathione peroxidase 4 (GPX4), resulting in proteasomal degradation.",311.19,"851398-76-0",{"v":20,"d":"20.00"},64.27,"<1","N/A","https://www.selleckchem.com/products/n6f11.html","C13H8Cl2N2OS","free base","N/A","ClCC1=NC(=O)C2=C(N1)C=C(S2)C3=CC=C(Cl)C=C3",3.789,2,1,2]
["E2668","Cirtuvivint","e3","L3000-50","in 10mM DMSO","CDK","Cell Cycle","Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimized for Wnt pathway inhibition. Cirtuvivint inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity. Cirtuvivint can be used for solid tumor research.",{"v":427.5,"d":"427.50"},"2143917-62-6",{"v":22,"d":"22.00"},51.46,"<1","N/A","https://www.selleckchem.com/products/cirtuvivint.html","C24H25N7O","free base","SM08502","CN1CCN(CC1)C2=CC(=CC=N2)C(=O)NC3=CC4=C(C=CC(=C4)C5=C[N](C)N=C5)C=N3",2.587,4,1,4]
["E4024","Poly-D-lysine hydrobromide","f3","L3000-50","in 10mM DMSO","Others","Others","Poly-D-lysine hydrobromide is a synthetic polymeric substrate most widely used in neural cell culture. It removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC.",{"v":227.1,"d":"227.10"},"27964-99-4",{"v":45,"d":"45.00"},198.15,{"v":45,"d":"45.00"},198.15,"https://www.selleckchem.com/products/poly-d-lysine-hydrobromide.html","(C6H14N2O2)x.xBrH","hydrobromide","N/A","Br.NCCCCC(N)C(O)=O",-2.749,1,2,5]
["E4312","CSRM617 hydrochloride","g3","L3000-50","in 10mM DMSO","Others","Others","CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor  ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. It induces apoptosis by appearance of cleaved Caspase-3 and PARP and  is well tolerated in the prostate cancer mouse model.",291.69,"1353749-74-2",{"v":58,"d":"58.00"},198.84,{"v":14,"d":"14.00"},{"v":48,"d":"48.00"},"https://www.selleckchem.com/products/csrm617-hydrochloride.html","C10H13N3O5.ClH","free base","N/A","Cl.NC(CO)C(=O)NN=CC1=C(O)C(=C(O)C=C1)O",-0.691,2,6,4]
["E4467","Temozolomide Acid","h3","L3000-50","in 10mM DMSO","Others","Others","Temozolomide acid is a carboxylic acid derivative of Temozolomide. It has an anticancer activity by causing breaks in DNA double strand, cell cycle arrest, and eventually cell death.",195.14,"113942-30-6",{"v":39,"d":"39.00"},199.86,"<1","N/A","https://www.selleckchem.com/products/temozolomide-acid.html","C6H5N5O3","free base","N/A","CN1N=NC2=C(N=C[N]2C1=O)C(O)=O",0.679,5,0,1]
["E4474","Infigratinib Phosphate","a4","L3000-50","in 10mM DMSO","FGFR","Angiogenesis","Infigratinib Phosphate (NVP-BGJ398 phosphate) is the phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human  fibroblast growth factor receptors (FGFRs)  with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for  FGFR1, FGFR2, FGFR3, and FGFR4 respectively. It also has potential antiangiogenic, antineoplastic and antitumor activities.",658.47,"1310746-10-1",{"v":100,"d":"100.00"},151.87,"<1","N/A","https://www.selleckchem.com/products/infigratinib-phosphate.html","C26H31Cl2N7O3.H3O4P","Phosphate","NVP-BGJ398 phosphate","CCN1CCN(CC1)C2=CC=C(NC3=CC(=NC=N3)N(C)C(=O)NC4=C(Cl)C(=CC(=C4Cl)OC)OC)C=C2.O[P](O)(O)=O",4.874,5,2,8]
["E4477","Lumateperone","b4","L3000-50","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Lumateperone (ITI-007) is an antagonist of 5-HT2A receptor with Ki of 0.54 nM. It has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.",{"v":393.5,"d":"393.50"},"313368-91-1",{"v":79,"d":"79.00"},200.76,"<1","N/A","https://www.selleckchem.com/products/lumateperone.html","C24H28FN3O","free base","ITI-007","CN1CCN2C3CCN(CCCC(=O)C4=CC=C(F)C=C4)CC3C5=CC=CC1=C25",3.765,1,0,5]
["S0987","MYCMI-6","c4","L3000-50","in 10mM DMSO","Myc","Cell Cycle","MYCMI-6 (NSC354961) is a potent and selective endogenous inhibitor of MYC:MAX protein interactions. MYCMI-6 blocks MYC-driven transcription and binds to the MYC bHLHZip domain with Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 of <0.5 μM. MYCMI-6 induces apoptosis.",373.41,"681282-09-7",{"v":38,"d":"38.00"},101.76,"<1","N/A","https://www.selleckchem.com/products/mycmi-6.html","C20H19N7O","free base","NSC354961","CCOC1=CC2=C(N)C3=C(C=C(C=C3)N=NC4=C(N)N=C(N)C=C4)N=C2C=C1",3.742,5,3,4]
["S3575","Zandelisib","d4","L3000-50","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Zandelisib(ME-401; PWT-143) is an orally bioavailable inhibitor of the phosphatidylinositide 3-kinase (PI3K). It selectively inhibits the delta isoform of PI3K (p110δ)  and prevents the activation of the PI3K/AKT signaling pathway with an IC50 of 3.5 nM. It functions as an antineoplastic agent.",576.68,"1401436-95-0",{"v":13,"d":"13.00"},22.54,"<1","N/A","https://www.selleckchem.com/products/zandelisib.html","C31H38F2N8O","free base","ME-401; PWT-143","CN1CCC(CC1)C2=C(CC(C)(C)NC3=NC(=NC(=N3)[N]4C(=NC5=CC=CC=C45)C(F)F)N6CCOCC6)C=CC=C2",6.503,5,1,8]
["S8395","INDY","e4","L3000-50","in 10mM DMSO","DYRK","Cell Cycle","INDY, a benzothiazole derivative is a potent and ATP-competitive inhibitor of Dyrk1A and Dyrk1B with an IC50 value of 0.24 μM and Ki value of 0.18 μM, respectively. INDY diminishes the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells.",{"v":235.3,"d":"235.30"},"1169755-45-6",{"v":47,"d":"47.00"},199.75,"<1","N/A","https://www.selleckchem.com/products/indy.html","C12H13NO2S","free base","N/A","CCN1/C(SC2=CC=C(O)C=C12)=C/C(C)=O",2.799,1,1,2]
["S8545","TEN-010 (RG6146,Ro-6870810,(S)-JQ-35)","f4","L3000-50","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","TEN-010 (RG6146, Ro-6870810,(S)-JQ-35) is an inhibitor of the Bromodomain and Extra-Terminal(BET) family bromodomain-containing proteins with potential antineoplastic activity.",540.13,"1349719-98-7",{"v":33,"d":"33.00"},{"v":61.1,"d":"61.10"},{"v":100,"d":"100.00"},185.14,"https://www.selleckchem.com/products/ten-010.html","C27H34ClN7OS","chloride","RG6146, Ro-6870810, (S)-JQ-35","CN1CCN(CCCNC(=O)CC2N=C(C3=CC=C(Cl)C=C3)C4=C(SC(=C4C)C)[N]5C(=NN=C25)C)CC1",3.533,4,1,7]
["S8617","Acriflavine","g4","L3000-50","in 10mM DMSO","HIF","Angiogenesis","Acriflavine is a HIF-1 dimerization inhibitor and have potent inhibitory effects on tumor growth and vascularization. It is used as fluorescent dye for labeling high molecular weight RNA.",468.98,"8048-52-0",{"v":94,"d":"94.00"},200.43,{"v":94,"d":"94.00"},200.43,"https://www.selleckchem.com/products/acriflavine.html","C14H14N3.C13H11N3.Cl","chloride","N/A","[Cl-].C[N+]1=C2C=C(N)C=CC2=CC3=C1C=C(N)C=C3.NC4=CC5=C(C=C4)C=C6C=CC(=CC6=N5)N",1.527,1,4,0]
["S9741","TAS-119","h4","L3000-50","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAS-119 is a potent, selective, and orally active inhibitor of Aurora A, including Aurora B with an IC50 of 1.0 nM and 95 nM, respectively. It exhibits antitumor activities.",506.36,"1453099-83-6",{"v":100,"d":"100.00"},197.49,"<1","N/A","https://www.selleckchem.com/products/tas-119.html","C23H22Cl2FN5O3","Chloride","N/A","CC1=CC(=N[NH]1)NC2=NC(=CC=C2F)CC3(CCN(CC3)C(=O)C4=C(Cl)C(=CC=C4)Cl)C(O)=O",4.859,4,2,6]
["S9969","RMC-4630","a5","L3000-50","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","RMC-4630 (SSE15206) is an inhibitor of microtubule polymerization with a GI50 of 197 nM in HCT116 cells. It can overcome multidrug resistance and cause aberrant mitosis, resulting in G2/M arrest due to incomplete spindle formation in cancer cells.",450.99,"2172652-48-9",{"v":45,"d":"45.00"},99.78,"<1","N/A","https://www.selleckchem.com/products/rmc-4630.html","C20H27ClN6O2S","Chloride","SSE15206","CC1OCC2(CCN(CC2)C3=NC(=C(SC4=CC=NC(=C4Cl)N)N=C3CO)C)C1N",1.624,4,3,4]
["E0305","UNC 3230","b5","L3000-50","in 10mM DMSO","Others","Others","UNC3230 is a potent, selective and ATP-competitive  PIP5K1C  inhibitor with an IC50 of ~41 nM and also inhibits  PIP4K2C . It also has antinociceptive and anticancer effects.",344.43,"1031602-63-7",{"v":69,"d":"69.00"},200.33,"<1","N/A","https://www.selleckchem.com/products/unc-3230.html","C₁₇H₂₀N₄O₂S","Free Base","N/A","NC(=O)C1=C(NC(=O)C2CCCCC2)SC(=N1)NC3=CC=CC=C3",3.179,3,3,5]
["E1028","POMHEX","c5","L3000-50","in 10mM DMSO","Others","Metabolism","POMHEX,  is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.",{"v":423.4,"d":"423.40"},"2004714-34-3",{"v":85,"d":"85.00"},200.76,{"v":5,"d":"5.00"},11.81,"https://www.selleckchem.com/products/pomhex.html","C17H30NO9P","phosphate","N/A","CC(C)(C)C(=O)OCO[P](=O)(OCOC(=O)C(C)(C)C)C1CCCN(O)C1=O",{"v":1.9,"d":"1.900"},7,0,11]
["E1203","Sirpiglenastat","d5","L3000-50","in 10mM DMSO","Glutaminase","Proteases","Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities.",441.48,"2079939-05-0",{"v":88,"d":"88.00"},199.33,"<1","N/A","https://www.selleckchem.com/products/sirpiglenastat.html","C22H27N5O5","free base","DRP-104","CC(C)OC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(C)=O",1.729,5,3,12]
["E1409","Zidesamtinib","e5","L3000-50","in 10mM DMSO","ROS1","Protein Tyrosine Kinase","Zidesamtinib (NVL-520) is a potent brain-penetrating inhibitor of ROS1 tyrosine kinase with IC50 of 0.7 nM for wild-type ROS1 . It acts as a potential antineoplastic agent and can be used for the research of cancer.",419.46,"2739829-00-4",{"v":84,"d":"84.00"},200.26,"<1","N/A","https://www.selleckchem.com/products/zidesamtinib.html","C22H22FN7O","free base","NVL-520, NVL520","CC[N]1N=CC2=C1C3=CC(=C(N)N=C3)OC(C)C4=CC(=CC=C4C5=N[N](C)N=C5C2)F",3.529,5,1,1]
["E1469","ITF3756","f5","L3000-50","in 10mM DMSO","HDAC6 selective inhibitors","DNA Damage/DNA Repair","ITF3756 is a selective histone deacetylase 6 (HDAC6) inhibitor bearing a pentaheterocyclic scaffold. It can be used in research of autoimmune disorders, neurodegenerative diseases, and cancer.",301.33,"2247608-27-9",{"v":60,"d":"60.00"},199.12,"<1","N/A","https://www.selleckchem.com/products/itf3756.html","C13H11N5O2S","free base","N/A","ONC(=O)C1=CC=C(C[N]2N=NN=C2C3=CC=CS3)C=C1",1.617,4,1,4]
["E1477","EP4-IN-1","g5","L3000-50","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor. It exhibits prospects in tumor immunity and anti-inflammatory analgesia research.",440.49,"2455480-28-9",{"v":88,"d":"88.00"},199.78,"<1","N/A","https://www.selleckchem.com/products/kf-0210.html","C27H24N2O4","free base","N/A","OC(=O)C12CC(C1)(C2)C3(CC3)NC(=O)C4=C5[N](CC6=CC7=CC=CC=C7O6)C=CC5=CC=C4",4.172,3,1,6]
["E1483","IK-930","h5","L3000-50","in 10mM DMSO","TEAD","Hippo","IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.",424.44,"2563892-44-2",{"v":85,"d":"85.00"},200.26,"<1","N/A","https://www.selleckchem.com/products/ik-930.html","C19H19F3N4O2S","free base","N/A","CN[S](=O)(=O)C1=CC(=C(NCC2=CC=C(C=C2)C(F)(F)F)C=C1)C3=C[N](C)C=N3",3.115,3,2,7]
["E1486","Zamaporvint (RXC004)","a6","L3000-50","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. It targets membrane-bound o-acyltransferase Porcupine and inhibits Wnt ligand palmitoylation, secretion, and pathway activation. RXC004 exhibits potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines and possesses multiple antitumor mechanisms.",439.39,"1900754-56-4",{"v":88,"d":"88.00"},200.28,"<1","N/A","https://www.selleckchem.com/products/rxc004.html","C21H16F3N7O","free base","N/A","CC1=C(N=C[N]1CC(=O)NC2=CC=C(C=N2)C3=NC=CN=C3)C4=CC=NC(=C4)C(F)(F)F",1.906,6,1,6]
["E1497","Tulmimetostat","b6","L3000-50","in 10mM DMSO","EZH1/2","Epigenetics","Tulmimetostat (CPI-0209) is an orally bioavailable and selective inhibitor of EZH2 that has therapeutic potential for androgen receptor-dependent prostate cancer.",562.12,"2567686-02-4",{"v":100,"d":"100.00"},{"v":177.9,"d":"177.90"},"<1","N/A","https://www.selleckchem.com/products/tulmimetostat.html","C28H36ClN3O5S","Chloride","CPI-0209","COC1CN(C1)C2CCC(CC2)C3(C)OC4=C(Cl)C=C(C(=O)NCC5=C(SC)C=C(C)NC5=O)C(=C4O3)C",{"v":3.48,"d":"3.480"},5,2,7]
["E1517","ZEN-3694","c6","L3000-50","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ZEN-3694 is an orally bioavailable  bromodomain extraterminal inhibitor (BETi)  that leads to down-regulation of expression of AR-signaling in metastatic castrationresistant prostate cancer (mCRPC) models.",333.39,"1643947-30-1",{"v":67,"d":"67.00"},200.97,"<1","N/A","https://www.selleckchem.com/products/zen-3694.html","C19H19N5O","free base","N/A","CNC1=NC2=NC=C(C=C2[N]1CC3=CC=CC=C3)C4=C(C)ON=C4C",{"v":2.93,"d":"2.930"},4,1,4]
["E1537","MMRi62","d6","L3000-50","in 10mM DMSO","MDM2/MDMX","Apoptosis","MMRi62 is a ferroptosis inducer, targeting MDM2-MDM4 with Kd value of 1.39 μM. It exhibits a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy.",396.27,"352693-80-2",{"v":79,"d":"79.00"},199.36,"<1","N/A","https://www.selleckchem.com/products/mmri62.html","C21H15Cl2N3O","free base","N/A","OC1=C(C=CC2=C1N=CC=C2)C(NC3=CC=CC=N3)C4=C(Cl)C(=CC=C4)Cl",5.496,2,2,4]
["S4684","Sildenafil","e6","L3000-50","in 10mM DMSO","PDE","Metabolism","Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.",474.58,"139755-83-2","N/A",">10","N/A","N/A","http://selleckchem.com/products/sildenafil.html","C22H30N6O4S","free base","Revatio, UK-92480, Viagra","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4",2.247,6,1,7]
["S7654","Defactinib (VS-6063)","f6","L3000-50","in 10mM DMSO","FAK","Angiogenesis","Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.",510.49,"1073154-85-4",{"v":100,"d":"100.00"},{"v":195.8,"d":"195.80"},"<1","N/A","http://selleckchem.com/products/defactinib.html","C20H21F3N8O3S","free base","PF-04554878","CNC(=O)C1=CC=C(NC2=NC(=C(C=N2)C(F)(F)F)NCC3=C(N=CC=N3)N(C)[S](C)(=O)=O)C=C1",1.774,7,3,9]
["S1037","Perifosine (KRX-0401)","a2","L3000-51","in 10mM Water","Akt","PI3K/Akt/mTOR","Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.",461.66,"157716-52-4","<1","N/A",{"v":8,"d":"8.00"},17.33,"http://selleckchem.com/products/Perifosine.html","C25H52NO4P","free base","NSC639966, D21266","CCCCCCCCCCCCCCCCCCO[P]([O-])(=O)OC1CC[N+](C)(C)CC1",4.607,2,0,20]
["S1116","Palbociclib (PD-0332991) HCl","b2","L3000-51","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",483.99,"827022-32-2",{"v":3,"d":"3.00"},{"v":6.2,"d":"6.20"},{"v":30,"d":"30.00"},61.98,"http://selleckchem.com/products/PD-0332991.html","C24H29N7O2.HCl","Hydrochloride","N/A","Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O",3.183,5,2,5]
["S1135","Pemetrexed (LY-231514) disodium","c2","L3000-51","in 10mM Water","Apoptosis related,Autophagy,DHFR,DNA/RNA Synthesis,Thymidylate Synthase","Metabolism","Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.",471.37,"150399-23-8","<1","N/A",{"v":94,"d":"94.00"},199.42,"http://selleckchem.com/products/Pemetrexed-disodium.html","C20H19N5Na2O6","Disodium salt","LY-231514 disodium","[Na+].[Na+].NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N1",-1.804,3,4,9]
["S1149","Gemcitabine (LY-188011) HCl","d2","L3000-51","in 10mM Water","Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.",299.66,"122111-03-9","<1","N/A",{"v":19,"d":"19.00"},63.41,"http://selleckchem.com/products/Gemcitabine-Hydrochloride(Gemzar).html","C9H11F2N3O4.HCI","Hydrochloride","NSC 613327,LY-188011 HCl","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.012,3,3,2]
["S1311","Pamidronate Disodium","e2","L3000-51","in 10mM Water","Others","Others","Pamidronate Disodium (CGP 23339AE) is a nitrogen containing bisphosphonate, used to prevent osteoporosis.",279.03,"57248-88-1","<1","N/A",{"v":56,"d":"56.00"},{"v":200.7,"d":"200.70"},"http://selleckchem.com/products/Pamidronate-Disodium.html","C3H9NNa2O7P2","Disodium salt","CGP 23339AE","[Na+].[Na+].NCCC(O)([P](O)([O-])=O)[P](O)([O-])=O",-5.016,0,1,4]
["S1339","Galanthamine HBr","f2","L3000-51","in 10mM Water","AChR,ADC Cytotoxin","Neuronal Signaling","Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.",368.27,"1953-04-4","<1","N/A",{"v":36,"d":"36.00"},97.75,"http://selleckchem.com/products/Galanthamine-hydrobromide.html","C17H21NO3.HBr","Hydrobromide","N/A","Br.COC1=CC=C2CN(C)CCC34C=CC(O)CC3OC1=C24",1.933,2,1,1]
["S1345","Granisetron HCl","g2","L3000-51","in 10mM Water","5-HT Receptor","Neuronal Signaling","Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.",348.87,"107007-99-8",{"v":1,"d":"1.00"},2.87,{"v":69,"d":"69.00"},197.78,"http://selleckchem.com/products/Granisetron-Hydrochloride.html","C18H24N4O.HCl","Hydrochloride","N/A","Cl.CN1C2CCCC1CC(C2)NC(=O)C3=N[N](C)C4=CC=CC=C34",2.783,2,1,2]
["S1375","Dorzolamide HCl","h2","L3000-51","in 10mM Water","Carbonic Anhydrase","Metabolism","Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.",{"v":360.9,"d":"360.90"},"130693-82-2","<1","N/A",{"v":14,"d":"14.00"},38.79,"http://selleckchem.com/products/Dorzolamide-HCL.html","C10H16N2O4S3.HCl","Hydrochloride","MK-507 (L-671152) HCl","Cl.CCNC1CC(C)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",0.527,4,2,3]
["S1440","Varenicline Tartrate (CP 526555-18)","a3","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Varenicline Tartrate (CP 526555-18, Chantix, Champix) is a nicotinic AChR partial agonist, used to treat nicotine addiction.",361.35,"375815-87-5",{"v":1,"d":"1.00"},2.77,{"v":72,"d":"72.00"},199.25,"http://selleckchem.com/products/Varenicline-tartrate.html","C13H13N3.C4H6O6","Tartrate","Chantix, Champix,CP 526555-18","OC(C(O)C(O)=O)C(O)=O.C1NCC2CC1C3=C2C=C4N=CC=NC4=C3",{"v":-3.33,"d":"-3.330"},4,3,3]
["S1494","Ralimetinib (LY2228820) dimesylate","b3","L3000-51","in 10mM Water","p38 MAPK","MAPK","Ralimetinib (LY2228820) dimesylate is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, does not alter p38 MAPK activation. Phase 1/2.",612.74,"862507-23-1",{"v":4,"d":"4.00"},6.53,{"v":100,"d":"100.00"},{"v":163.2,"d":"163.20"},"http://selleckchem.com/products/LY2228820.html","C24H29FN6.2CH4O3S","dimesylate","N/A","CC(C)(C)C[N]1C(=NC2=CC=C(N=C12)C3=C(N=C([NH]3)C(C)(C)C)C4=CC=C(F)C=C4)N.C[S;v6](O)(=O)=O",5.117,3,2,5]
["S1506","Perindopril Erbumine","c3","L3000-51","in 10mM Water","RAAS","Endocrinology & Hormones","Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.",{"v":441.6,"d":"441.60"},"107133-36-8","<1","N/A",{"v":88,"d":"88.00"},199.28,"http://selleckchem.com/products/Perindopril-Erbumine(Aceon).html","C19H32N2O5.C4H11N","t-Butylamine","S9490-3","CCCC(NC(C)C(=O)N1C2CCCCC2CC1C(O)=O)C(=O)OCC.CC(C)(C)N",0.016,4,2,9]
["S1516","Cidofovir","d3","L3000-51","in 10mM Water","CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Cidofovir (HPMPC,Vistide,GS 0504) suppresses virus replication by selective inhibition of viral DNA synthesis.",279.19,"113852-37-2",{"v":2,"d":"2.00"},7.16,{"v":12,"d":"12.00"},42.98,"http://selleckchem.com/products/Cidofovir.html","C8H14N3O6P","Free Base","HPMPC,Vistide,GS 0504","NC1=NC(=O)N(CC(CO)OC[P](O)(O)=O)C=C1",-2.175,3,2,6]
["S1518","Ibuprofen Lysine","e3","L3000-51","in 10mM Water","COX","Neuronal Signaling","Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.",352.47,"57469-77-9","<1","N/A",{"v":71,"d":"71.00"},201.44,"http://selleckchem.com/products/Ibuprofen-Lysine(Motrin).html","C19H32N2O4","Lysine","N/A","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O.NCCCCC(N)C(O)=O",-2.112,2,2,9]
["S1579","Palbociclib (PD0332991) Isethionate","f3","L3000-51","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",573.66,"827022-33-3","<1","N/A",{"v":10,"d":"10.00"},17.43,"http://selleckchem.com/products/pd-0332991-palbociclib-isethionate.html","C24H29N7O2.C2H6O4S","Isethionate","N/A","CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O.OCC[S](O)(=O)=O",1.847,5,3,7]
["S1624","Alendronate sodium trihydrate","g3","L3000-51","in 10mM Water","Others","Metabolism","Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.",326.13,"121268-17-5","<1","N/A",{"v":20,"d":"20.00"},61.33,"http://selleckchem.com/products/Alendronate-Sodium(Fosamax).html","C4H13NO7P2.3H2O.Na","Sodium Salt","G-704650, MK-217","O.O.O.NCCCC(O)([P](O)(O)=O)[P](O)(=O)O[Na]",{"v":0,"d":"0.000"},0,0,0]
["S1648","Cytarabine (U-19920A)","h3","L3000-51","in 10mM Water","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459,U-19920A) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.",243.22,"147-94-4",{"v":1,"d":"1.00"},4.11,{"v":48,"d":"48.00"},197.35,"http://selleckchem.com/products/Cytarabine(Cytosar-U).html","C9H13N3O5","free base","Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459,U-19920A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S1853","Penicillamine","a4","L3000-51","in 10mM Water","Others","Others","Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease.",149.21,"52-67-5","<1","N/A",{"v":30,"d":"30.00"},201.06,"http://selleckchem.com/products/Penicillamine(Cuprimine).html","C5H11NO2S","free base","Dimethyl Cysteine","CC(C)(S)C(N)C(O)=O",-2.496,1,1,2]
["S1857","Etidronate","b4","L3000-51","in 10mM Water","phosphatase","Metabolism","Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.",206.03,"2809-21-4","<1","N/A",{"v":41,"d":"41.00"},{"v":199,"d":"199.00"},"http://selleckchem.com/products/etidronate-didronel.html","C2H8O7P2","free base","N/A","CC(O)([P](O)(O)=O)[P](O)(O)=O",-0.701,0,0,2]
["S1875","Tranexamic Acid","c4","L3000-51","in 10mM Water","Others","Others","Tranexamic Acid(Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.",157.21,"1197-18-8","<1","N/A",{"v":31,"d":"31.00"},197.19,"http://selleckchem.com/products/tranexamic-acid-transamin.html","C8H15NO2","free base","Transamin","NCC1CCC(CC1)C(O)=O",-1.753,1,1,2]
["S1984","Ticlopidine HCl","d4","L3000-51","in 10mM Water","P2 Receptor","Neuronal Signaling","Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.",300.25,"53885-35-1",{"v":1,"d":"1.00"},3.33,{"v":4,"d":"4.00"},13.32,"http://selleckchem.com/products/ticlopidine-hydrochloride.html","C14H14ClNS.HCl","Hydrochloride","N/A","Cl.ClC1=C(CN2CCC3=C(C2)C=CS3)C=CC=C1",4.275,0,0,2]
["S1995","Procarbazine HCl","e4","L3000-51","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.",257.76,"366-70-1","<1","N/A",{"v":52,"d":"52.00"},201.74,"http://selleckchem.com/products/procarbazine-hydrochloride-matulane.html","C12H19N3O.HCl","Hydrochloride","NSC-77213 HCl","Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C",{"v":1.12,"d":"1.120"},1,3,5]
["S1999","Sodium butyrate","f4","L3000-51","in 10mM Water","Apoptosis related,Autophagy,HDAC","Epigenetics","Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.",110.09,"156-54-7","<1","N/A",{"v":22,"d":"22.00"},199.84,"http://selleckchem.com/products/Sodium-butyrate.html","C4H7NaO2","Sodium Salt","NaB, Butanoic acid sodium salt","[Na+].CCCC([O-])=O",-0.556,0,0,2]
["S2000","Sodium orthovanadate","g4","L3000-51","in 10mM Water","ATPase","Transmembrane Transporters","Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.",183.91,"13721-39-6","<1","N/A",{"v":36,"d":"36.00"},195.75,"http://selleckchem.com/products/Sodium-orthovanadate.html","Na3O4V","Sodium Salt","N/A","[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O",-3.177,0,0,0]
["S2008","Taurine","h4","L3000-51","in 10mM Water","Others","Others","Taurine is an organic acid widely distributed in animal tissues.",125.15,"107-35-7","<1","N/A",{"v":20,"d":"20.00"},159.81,"http://selleckchem.com/products/Taurine.html","C2H7NO3S","free base","N/A","NCC[S](O)(=O)=O",-1.243,0,1,2]
["S2048","Clindamycin Phosphate","a5","L3000-51","in 10mM Water","Antibiotics","Microbiology","Clindamycin Phosphate (NSC 618653) is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM.",504.96,"24729-96-2","<1","N/A",{"v":101,"d":"101.00"},200.02,"http://selleckchem.com/products/clindamycin-phosphate.html","C18H34ClN2O8PS","free base","NSC 618653","CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O[P](O)(O)=O)C(O)C2O",1.205,3,3,9]
["S2076","Lisinopril dihydrate","b5","L3000-51","in 10mM Water","ACE,RAAS","Endocrinology & Hormones","Lisinopril dihydrate(MK-521 dihydrate) is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.",441.52,"83915-83-7","<1","N/A",{"v":20,"d":"20.00"},49.32,"http://selleckchem.com/products/lisinopril-zestril.html","C21H35N3O7","free base","MK-521 dihydrate","NCCCCC(NC(CCC1=CC=CC=C1)C(O)=O)C(=O)N2CCCC2C(O)=O",-3.673,3,2,12]
["S2129","Fudosteine","c5","L3000-51","in 10mM Water","Others","Metabolism","Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.",179.24,"13189-98-5","<1","N/A",{"v":36,"d":"36.00"},200.85,"http://selleckchem.com/products/Fudosteine.html","C6H13NO3S","free base","N/A","NC(CSCCCO)C(O)=O",-3.373,1,2,6]
["S2133","Gabapentin","d5","L3000-51","in 10mM Water","GABA Receptor","Neuronal Signaling","Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.",171.24,"60142-96-3","<1","N/A",{"v":34,"d":"34.00"},198.55,"http://selleckchem.com/products/Gabapentin(Neurontin).html","C9H17NO2","Free Base","N/A","NCC1(CCCCC1)CC(O)=O",-1.486,1,1,3]
["S2420","Aloperine","e5","L3000-51","in 10mM Water","Antiviral,Bacterial","Microbiology","Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.",232.36,"56293-29-9",{"v":2,"d":"2.00"},8.61,{"v":12,"d":"12.00"},51.64,"http://selleckchem.com/products/aloperine.html","C15H24N2","Free Base","N/A","C1CCN2CC3CC(C=C4CCCNC34)C2C1",1.998,0,1,0]
["S2462","Donepezil HCl","f5","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.",{"v":416,"d":"416.00"},"120011-70-3","<1","N/A",{"v":5,"d":"5.00"},12.02,"http://selleckchem.com/products/Donepezil-hydrochloride(Aricept).html","C24H29NO3.HCl","Hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)CC2=C1",4.951,3,0,6]
["S2490","Neostigmine Bromide","g5","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.",{"v":303.2,"d":"303.20"},"114-80-7","<1","N/A",{"v":60,"d":"60.00"},197.89,"http://selleckchem.com/products/Neostigmine-bromide(Prostigmin).html","C12H19N2O2.Br","Bromide","N/A","[Br-].CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C",-1.907,2,0,3]
["S2507","Salbutamol Sulfate","h5","L3000-51","in 10mM Water","Adrenergic Receptor","Neuronal Signaling","Salbutamol Sulfate (Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.",337.39,"51022-70-9","<1","N/A",{"v":68,"d":"68.00"},201.55,"http://selleckchem.com/products/Salbutamol-sulfate(Albuterol).html","C13H21NO3.H2SO4","Sulfate","Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent","CC(C)(C)NCC(O)C1=CC=C(O)C(=C1)CO.O[S](O)(=O)=O",0.334,0,4,5]
["S2527","Methacycline HCl","a6","L3000-51","in 10mM Water","Antibiotics","Microbiology","Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.",478.88,"3963-95-9",{"v":3,"d":"3.00"},6.26,{"v":5,"d":"5.00"},10.44,"http://selleckchem.com/products/Methacycline-hydrochloride-Physiomycine.html","C22H22N2O8.HCl","Hydrochloride","Rondomycin","Cl.CN(C)C1C2C(O)C3C(=C)C4=CC=CC(=C4C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O)O",-0.565,3,5,2]
["S2539","Lomefloxacin HCl","b6","L3000-51","in 10mM Water","Antibiotics","Microbiology","Lomefloxacin HCl is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic.",387.81,"98079-52-8",{"v":1,"d":"1.00"},2.58,{"v":6,"d":"6.00"},15.47,"http://selleckchem.com/products/Lomefloxacin-hydrochloride-Maxaquin.html","C17H19F2N3O3.HCl","Hydrochloride","N/A","Cl.CCN1C=C(C(O)=O)C(=O)C2=CC(=C(N3CCNC(C)C3)C(=C12)F)F",-0.446,2,1,3]
["S2877","L-NAME HCl","c6","L3000-51","in 10mM Water","NOS","Immunology & Inflammation","L-NAME HCl (NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester) is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.",269.69,"51298-62-5","<1","N/A",{"v":54,"d":"54.00"},200.23,"http://selleckchem.com/products/l-name-hcl.html","C7H15N5O4.HCl","Hydrochloride","NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester","Cl.COC(=O)C(N)CCCNC(=N)N[N+]([O-])=O",1.463,2,3,9]
["S2879","AMD3465 hexahydrobromide","d6","L3000-51","in 10mM Water","CXCR","GPCR & G Protein","AMD3465 is a monomacrocyclic CXCR4 antagonist.",896.07,"185991-07-5, 185991-24-6 (free base)",{"v":2,"d":"2.00"},2.23,{"v":98,"d":"98.00"},109.37,"http://selleckchem.com/products/amd3465.html","C24H38N6.6HBr","HBr","N/A","Br.Br.Br.Br.Br.Br.C1CNCCNCCCN(CCNC1)CC2=CC=C(CNCC3=NC=CC=C3)C=C2",3.787,1,4,6]
["S3013","Plerixafor (AMD3100) 8HCl","e6","L3000-51","in 10mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.",794.47,"155148-31-5","<1","N/A",{"v":100,"d":"100.00"},125.87,"http://selleckchem.com/products/plerixafor-8hcl-db06809.html","C28H54N8.8HCl","Octahydrochloride","JM 3100 8HCl,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride","Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",2.536,0,6,4]
["S3048","Solifenacin succinate","f6","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.",480.55,"242478-38-2",{"v":3,"d":"3.00"},6.24,{"v":96,"d":"96.00"},199.77,"http://selleckchem.com/products/solifenacin-succinate.html","C23H26N2O.C4H6O4","Succinate","YM905","OC(=O)CCC(O)=O.O=C(OC1CN2CCC1CC2)N3CCC4=C(C=CC=C4)C3C5=CC=CC=C5",0.635,4,0,6]
["S3050","Palonosetron HCl","g6","L3000-51","in 10mM Water","5-HT Receptor","Neuronal Signaling","Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.",332.87,"135729-62-3","<1","N/A",{"v":67,"d":"67.00"},201.28,"http://selleckchem.com/products/palonosetron-hcl.html","C19H24N2O.HCl","HCL","RS 25259, RS 25259 197","Cl.O=C1N(CC2CCCC3=CC=CC1=C23)C4CN5CCC4CC5",3.127,1,0,1]
["S3056","Miltefosine","h6","L3000-51","in 10mM Water","Akt","PI3K/Akt/mTOR","Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.",407.57,"58066-85-6","<1","N/A",{"v":81,"d":"81.00"},198.74,"http://selleckchem.com/products/miltefosine-hexadecylphosphocholine.html","C21H46NO4P","free base","Hexadecylphosphocholine","CCCCCCCCCCCCCCCCO[P]([O-])(=O)OCC[N+](C)(C)C",3.722,2,0,20]
["S3058","Danofloxacin Mesylate","a7","L3000-51","in 10mM Water","Bacterial","Microbiology","Danofloxacin (CP-76136-27) is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM.",453.48,"119478-55-6","<1","N/A",{"v":91,"d":"91.00"},200.67,"http://selleckchem.com/products/danofloxacin-mesylate.html","C19H20FN3O3.CH4O3S","Mesylate","CP-76136-27","CN1CC2CC1CN2C3=CC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(O)=O.C[S](O)(=O)=O",-1.539,2,0,3]
["S3072","(R)-baclofen","b7","L3000-51","in 10mM Water","GABA Receptor","Neuronal Signaling","(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.",213.66,"69308-37-8","<1","N/A",{"v":8,"d":"8.00"},37.44,"http://selleckchem.com/products/r-baclofen.html","C10H12ClNO2","free base","STX 209","NCC(CC(O)=O)C1=CC=C(Cl)C=C1",{"v":-1.06,"d":"-1.060"},1,1,4]
["S3146","Tripelennamine HCl","c7","L3000-51","in 10mM Water","Histamine Receptor","Neuronal Signaling","Tripelennamine (Pyribenzamine) is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.",291.82,"154-69-8",{"v":2,"d":"2.00"},6.85,{"v":58,"d":"58.00"},198.75,"http://selleckchem.com/products/tripelennamine-hydrochloride.html","C16H21N3.HCl","HCl","Pyribenzamine HCl","Cl.CN(C)CCN(CC1=CC=CC=C1)C2=NC=CC=C2",3.484,1,0,6]
["S3148","Ibandronate sodium monohydrate","d7","L3000-51","in 10mM Water","Others","Others","Ibandronate (BM-21.0955, BM-210955, RPR-102289A) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.",360.23,"138926-19-9","<1","N/A",{"v":72,"d":"72.00"},199.87,"http://selleckchem.com/products/ibandronate-sodium.html","C9H23NO7P2.Na.H2O","sodium monohydrate","BM-21.0955, BM-210955, RPR-102289A","O.[NaH].CCCCCN(C)CCC(O)([P](O)(O)=O)[P](O)(O)=O",0.477,0,0,9]
["S3174","L-Arginine HCl (L-Arg)","e7","L3000-51","in 10mM Water","NOS","Immunology & Inflammation","L-Arginine(L-Arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.",210.66,"1119-34-2","<1","N/A",{"v":42,"d":"42.00"},199.37,"http://selleckchem.com/products/l-Arginine-hydrochloride.html","C6H14N4O2.HCl","HCl","(S)-(+)-Arginine hydrochloride","Cl.NC(CCCNC(N)=N)C(O)=O",-3.449,1,3,6]
["S3649","Ceftazidime","f7","L3000-51","in 10mM Water","Anti-infection,Selection Antibiotics for Transfected Cell","Microbiology","Ceftazidime(GR20263) is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.",546.58,"72558-82-8",{"v":4,"d":"4.00"},7.32,{"v":100,"d":"100.00"},182.96,"http://selleckchem.com/products/ceftazidime.html","C22H22N6O7S2","inner salt","GR20263","CC(C)(O\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3=CC=CC=C3)C4=CSC(=N4)N)C(O)=O",-0.693,6,2,9]
["S3662","Pirenzepine dihydrochloride","g7","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.",424.32,"29868-97-1",{"v":1,"d":"1.00"},2.36,{"v":84,"d":"84.00"},197.96,"http://selleckchem.com/products/pirenzepine-dihydrochloride.html","C19H21N5O2.2HCl","dihydrochloride","N/A","Cl.Cl.CN1CCN(CC1)CC(=O)N2C3=C(C=CC=C3)C(=O)NC4=CC=CN=C24",1.803,3,1,2]
["S3667","Imipenem","h7","L3000-51","in 10mM Water","β-lactamase","Microbiology","Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections.",317.36,"74431-23-5",{"v":1,"d":"1.00"},3.15,{"v":63,"d":"63.00"},198.51,"http://selleckchem.com/products/imipenem.html","C12H17N3O4S.H2O","hydrate","N/A","O.CC(O)C1C2CC(=C(N2C1=O)C(O)=O)SCCNC=N",-1.825,2,2,7]
["S3748","Acamprosate Calcium","a8","L3000-51","in 10mM Water","GABA Receptor","Transmembrane Transporters","Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.",200.24,"77337-73-6","<1","N/A",{"v":40,"d":"40.00"},199.76,"http://selleckchem.com/products/acamprosate-calcium.html","C5H11NO4S.1/2Ca","calcium salt","N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate,N-acetylhomotaurinate","CC(=O)NCCC[S]([O-])(=O)=O",{"v":-2.67,"d":"-2.670"},1,1,4]
["S3752","isoleucine","b8","L3000-51","in 10mM Water","Others","Others","Isoleucine (Ile) is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins.",131.17,"73-32-5","<1","N/A",{"v":26,"d":"26.00"},198.22,"http://selleckchem.com/products/isoleucine.html","C6H13NO2","free base","Ile","CCC(C)C(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3861","Sodium Demethylcantharidate","c8","L3000-51","in 10mM Water","PP2A","PI3K/Akt/mTOR","Demethylcantharidin (norcantharidin) is a synthetic analogue of cantharidin and has potent antitumor activity.",208.14,"13114-29-9","<1","N/A",{"v":41,"d":"41.00"},196.98,"http://selleckchem.com/products/sodium-demethylcantharidate.html","C8H9O5.Na","free base","Sodium norcantharidin","OC(=O)C1C2CCC(O2)C1C(=O)O[Na]",{"v":0,"d":"0.000"},0,0,0]
["S3963","DL-Glutamine","d8","L3000-51","in 10mM Water","Others","Others","DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes.",146.14,"6899-04-3","<1","N/A",{"v":29,"d":"29.00"},198.44,"http://selleckchem.com/products/dl-glutamine.html","C5H10N2O3","free base","Glutamin, 2-amino-4-carbamoylbutanoic acid","NC(CCC(N)=O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3973","L-SelenoMethionine","e8","L3000-51","in 10mM Water","ROS","Immunology & Inflammation","L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.",196.11,"3211-76-5","<1","N/A",{"v":39,"d":"39.00"},198.87,"http://selleckchem.com/products/l-selenomethionine.html","C5H11NO2Se","free base","N/A","C[Se]CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4008","Pemirolast potassium","f8","L3000-51","in 10mM Water","Histamine Receptor","Neuronal Signaling","Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.",{"v":266.3,"d":"266.30"},"100299-08-9","<1","N/A",{"v":53,"d":"53.00"},199.02,"http://selleckchem.com/products/pemirolast-bmy-26517-potassium.html","C10H7N6O.K","Potassium","BMY26517","[K+].CC1=CC=CN2C(=O)C(=CN=C12)C3=NN=N[N-]3",-1.246,5,0,1]
["S4027","Flavoxate HCl","g8","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Flavoxate (NSC-114649) is a muscarinic AChR antagonist with IC50 of 12.2 μM.",427.92,"3717-88-2",{"v":3,"d":"3.00"},7.01,{"v":10,"d":"10.00"},23.37,"http://selleckchem.com/products/flavoxate-hcl.html","C24H25NO4.HCl","hydrochloride","NSC-114649","Cl.CC1=C(OC2=C(C=CC=C2C(=O)OCCN3CCCCC3)C1=O)C4=CC=CC=C4",4.876,4,0,6]
["S4028","Dexamethasone Sodium Phosphate","h8","L3000-51","in 10mM Water","Autophagy,Complement System,COVID-19,COX,IL Receptor","Immunology & Inflammation","Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":516.4,"d":"516.40"},"55203-24-2","<1","N/A",{"v":103,"d":"103.00"},199.46,"http://selleckchem.com/products/dexamethasone-sodium-phosphate.html","C22H30FO8P.2Na","Disodium salt","Dexamethasone 21-phosphate disodium salt","[Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O",-0.541,3,1,4]
["S4030","Gentamicin Sulfate","a9","L3000-51","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.","N/A","1405-41-0","<1","N/A",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"http://selleckchem.com/products/gentamicin-sulfate.html","H2SO4.xUnspecified","Sulfate","NSC-82261, SCH9724","CCN.CNC(C)C.CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(CCC3N)[R])C2O.CC(C)N.O[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4069","Hexamethonium Dibromide","b9","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.",362.19,"55-97-0","<1","N/A",{"v":73,"d":"73.00"},201.55,"http://selleckchem.com/products/hexamethonium-bromide.html","C12H30N2.2Br","Bromide","N/A","[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C",-5.532,0,0,7]
["S4094","Tetramisole HCl","c9","L3000-51","in 10mM Water","Parasite","Microbiology","Tetramisole(R-829,(±)-Tetramisole hydrochloride) is a mixture of dextro- and levo isomers used as an anthelmintic.",240.75,"5086-74-8","<1","N/A",{"v":41,"d":"41.00"},{"v":170.3,"d":"170.30"},"http://selleckchem.com/products/tetramisole-hcl.html","C11H12N2S.HCl","Hydrochloride","R-829,(±)-Tetramisole hydrochloride","Cl.C1CN2CC(N=C2S1)C3=CC=CC=C3",2.672,1,0,1]
["S4108","Clodronate Disodium","d9","L3000-51","in 10mM Water","Others","Metabolism","Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.",288.86,"22560-50-5","<1","N/A",{"v":72,"d":"72.00"},249.26,"http://selleckchem.com/products/clodronate-disodium.html","CH4Cl2O6P0.2Na","Disodium salt","N/A","[Na+].[Na+].O[P]([O-])(=O)C(Cl)(Cl)[P](O)([O-])=O",-1.706,0,0,2]
["S4117","Histamine Phosphate","e9","L3000-51","in 10mM Water","Histamine Receptor","Neuronal Signaling","Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.",307.14,"51-74-1","<1","N/A",{"v":42,"d":"42.00"},136.75,"http://selleckchem.com/products/histamine-phosphate.html","C5H9N.2H3O4P","Phosphate","Histamine diphosphate","NCCC1=C[NH]C=N1.O[P](O)(O)=O.O[P](O)(O)=O",-1.651,1,2,2]
["S4121","Succinylcholine Chloride Dihydrate","f9","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Succinylcholine Chloride Dihydrate (Suxamethonium) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.",397.34,"6101-15-1",{"v":1,"d":"1.00"},2.52,{"v":79,"d":"79.00"},198.82,"http://selleckchem.com/products/succinylcholine-suxamethonium-chloride-dihydrate.html","C14H30N2O4.2Cl.2H2O","Chloride","Suxamethonium Chloride Dihydrate","O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C",-8.102,4,0,11]
["S4127","Terbutaline Sulfate","g9","L3000-51","in 10mM Water","Adrenergic Receptor","GPCR & G Protein","Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.",548.65,"23031-32-5","<1","N/A",{"v":100,"d":"100.00"},182.27,"http://selleckchem.com/products/terbutaline-sulfate.html","C24H38N2O6.H2SO4","Sulfate","Terbutaline hemisulfate","CC(C)(C)NCC(O)C1=CC(=CC(=C1)O)O.CC(C)(C)NCC(O)C2=CC(=CC(=C2)O)O.O[S](O)(=O)=O",2.001,0,8,8]
["S4144","Amprolium HCl","h9","L3000-51","in 10mM Water","Vitamin","Metabolism","Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.",315.24,"137-88-2",{"v":2,"d":"2.00"},6.34,{"v":63,"d":"63.00"},199.85,"http://selleckchem.com/products/amprolium-hcl.html","C14H19N4.HCl.Cl","Hydrochloride","N/A","Cl.[Cl-].CCCC1=NC=C(C[N+]2=C(C)C=CC=C2)C(=N1)N",-0.036,2,1,4]
["S4157","Chloroquine diphosphate","a10","L3000-51","in 10mM Water","Anti-infection,ATM/ATR,Autophagy,COVID-19,TLR","PI3K/Akt/mTOR","Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).",515.86,"50-63-5","<1","N/A",{"v":100,"d":"100.00"},193.85,"http://selleckchem.com/products/chloroquine-phosphate.html","C18H26ClN3.2H3O4P","diphosphate","N/A","CCN(CC)CCCC(C)NC1=CC=NC2=C1C=CC(=C2)Cl.O[P](O)(O)=O.O[P](O)(O)=O",3.408,1,1,8]
["S4158","Ceftriaxone disodium salt hemi (heptahydrate)","b10","L3000-51","in 10mM Water","Antibiotics","Microbiology","Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.",{"v":661.6,"d":"661.60"},"104376-79-6",{"v":1,"d":"1.00"},1.51,{"v":100,"d":"100.00"},151.15,"http://selleckchem.com/products/ceftriaxone-sodium-trihydrate.html","C18H16N8O7S3.7/2H2O.2Na","disodium salt hemi","N/A","O.[Na;v0].CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)CSC3=NC(=O)C(=O)NN3C)C4=CSC(=N4)N",-1.716,8,2,8]
["S4183","Paromomycin Sulfate","c10","L3000-51","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Paromomycin Sulfate(Aminosidine sulfate) is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.",713.71,"1263-89-4","<1","N/A",{"v":100,"d":"100.00"},140.11,"http://selleckchem.com/products/paromomycin-sulfate.html","C23H45N5O14.xH2SO4","Sulfate","Aminosidine sulfate","NCC1OC(OC2C(O)C(OC2CO)OC3C(O)C(N)CC(N)C3OC4OC(CO)C(O)C(O)C4N)C(N)C(O)C1O.O[S](O)(=O)=O",-9.277,6,13,9]
["S4236","Proflavine Hemisulfate","d10","L3000-51","in 10mM Water","Anti-infection,DNA/RNA Synthesis","Microbiology","Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.",258.25,"1811-28-5","<1","N/A",{"v":22,"d":"22.00"},85.19,"http://selleckchem.com/products/proflavine-hemisulfate.html","C13H11N3.1/2H2SO4","Sulfate","N/A","NC1=CC=C2C=C3C=CC(=CC3=NC2=C1)N.NC4=CC=C5C=C6C=CC(=CC6=NC5=C4)N.O[S](O)(=O)=O",3.113,2,4,0]
["S4245","Sodium ascorbate","e10","L3000-51","in 10mM Water","Vitamin","Metabolism","Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.",198.11,"134-03-2",{"v":2,"d":"2.00"},9.94,{"v":40,"d":"40.00"},198.88,"http://selleckchem.com/products/sodium-ascorbate.html","C6H7NaO6","Sodium Salt","Sodium Vitamin C","[NaH].OCC(O)C1OC(=O)C(O)C1O",-2.229,2,4,2]
["S4254","Apramycin Sulfate","f10","L3000-51","in 10mM Water","Antibiotics","Microbiology","Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA.",637.66,"65710-07-8","<1","N/A",{"v":100,"d":"100.00"},156.82,"http://selleckchem.com/products/apramycin-sulfate.html","C21H41N5O11.xH2SO4","Sulfate","Ai3-29795","CNC1C(O)C2OC(OC3C(N)CC(N)C(O)C3O)C(N)CC2OC1OC4OC(CO)C(N)C(O)C4O.O[S](O)(=O)=O",{"v":-7.63,"d":"-7.630"},5,11,6]
["S4360","Tolmetin Sodium","g10","L3000-51","in 10mM Water","COX","Immunology & Inflammation","Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.",{"v":315.3,"d":"315.30"},"64490-92-2","<1",{"v":0,"d":"0.00"},{"v":63,"d":"63.00"},199.81,"http://www.selleckchem.com/products/tolmetin-sodium.html","C15H14NO3.Na.2H2O","sodium","MCN2559","O.O.C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(=O)O[Na]",2.943,3,0,5]
["S4430","Hydroxychloroquine Sulfate (NSC 4375)","h10","L3000-51","in 10mM Water","Anti-infection,Autophagy,COVID-19,TLR","Autophagy","Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.",433.95,"747-36-4","<1","N/A",{"v":67,"d":"67.00"},{"v":154.4,"d":"154.40"},"http://selleckchem.com/products/hydroxychloroquine-sulfate.html","C18H28ClN3O5S","Sulfate","HCQ","CCN(CCO)CCCC(C)NC1=CC=NC2=CC(=CC=C12)Cl.O[S](O)(=O)=O",{"v":2.85,"d":"2.850"},1,2,9]
["S4575","Pralidoxime chloride","a11","L3000-51","in 10mM Water","AChR","Neuronal Signaling","Pralidoxime chloride (2-PAM) is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.",172.61,"51-15-0","<1","N/A",{"v":34,"d":"34.00"},196.98,"http://selleckchem.com/products/pralidoxime-chloride.html","C7H9N2O.Cl","chloride","2-PAM (chloride)","[Cl-].C[N+]1=C(C=CC=C1)\\C=N\\O",-1.122,1,0,1]
["S4582","Eflornithine (MDL-71782) hydrochloride hydrate","b11","L3000-51","in 10mM Water","Decarboxylase","Metabolism","Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.",236.64,"96020-91-6","<1","N/A",{"v":47,"d":"47.00"},198.61,"http://selleckchem.com/products/eflornithine-hydrochloride-hydrate.html","C6H12F2N2O2.HCl.H2O","hydrochloride hydrate","Difluoromethylornithine hydrochloride hydrate, DFMO hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate","O.Cl.NCCCC(N)(C(F)F)C(O)=O",-3.046,1,2,5]
["S4606","Glutathione","c11","L3000-51","in 10mM Water","Glutathione","Metabolism","Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.",307.32,"70-18-8","<1","N/A",{"v":61,"d":"61.00"},198.49,"http://selleckchem.com/products/glutathione.html","C10H17N3O6S","free base","Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine","NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O",-4.772,4,3,9]
["S4653","L-Ornithine hydrochloride","d11","L3000-51","in 10mM Water","Others","Others","L-ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.",168.62,"3184-13-2","<1","N/A",{"v":26,"d":"26.00"},196.73,"https://www.selleckchem.com/products/l-ornithine-hydrochloride.html","C5H13ClN2O2","free base","(S)-2,5-Diaminopentanoic acid","Cl.NCCCC(N)C(O)=O",-3.697,1,2,4]
["S4671","Cefradine","e11","L3000-51","in 10mM Water","Antibiotics","Microbiology","Cefradine (Cephradine, Sefril, Anspor, Velosef) is a semi-synthetic cephalosporin antibiotic.",{"v":349.4,"d":"349.40"},"38821-53-3","<1","N/A",{"v":10,"d":"10.00"},28.62,"http://selleckchem.com/products/cefradine.html","C16H19N3O4S","free base","Cephradine, Sefril, Anspor, Cephradin, Velosef","CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CCC=CC3)C2=O)C(O)=O",-2.277,3,2,4]
["S4700","4-Aminobutyric acid (GABA)","f11","L3000-51","in 10mM Water","GABA Receptor","Neuronal Signaling","4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.",103.12,"56-12-2","<1","N/A",{"v":20,"d":"20.00"},193.95,"http://selleckchem.com/products/4-aminobutyric-acid.html","C4H9NO2","free base","4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid","NCCCC(O)=O",-3.076,1,1,3]
["S4702","Sarcosine","g11","L3000-51","in 10mM Water","Amino acid transporter,GlyT,NMDAR","Neuronal Signaling","Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.",89.09,"107-97-1","<1","N/A",{"v":17,"d":"17.00"},190.82,"http://selleckchem.com/products/sarcosine.html","C3H7NO2","free base","N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine","CNCC(O)=O",-3.439,1,1,2]
["S4740","Sodium ferulate","h11","L3000-51","in 10mM Water","5-HT Receptor","Neuronal Signaling","Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.",216.17,"24276-84-4",{"v":2,"d":"2.00"},9.25,{"v":43,"d":"43.00"},198.92,"http://selleckchem.com/products/ferulic-acid-sodium.html","C10H9O4.Na","Sodium salt","Ferulic acid sodium salt","[Na+].COC1=CC(=CC=C1O)\\C=C\\C([O-])=O",0.195,1,1,3]
["S4741","Danshensu","a2","L3000-52","in 10mM Water","P450 (e.g. CYP17)","Metabolism","Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. Danshensu inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively.",198.17,"76822-21-4","<1","N/A",{"v":23,"d":"23.00"},116.06,"http://selleckchem.com/products/danshensu.html","C9H10O5","free base","Salvianic acid A","OC(CC1=CC=C(O)C(=C1)O)C(O)=O",0.679,1,3,3]
["S4786","S-Methyl-L-cysteine","b2","L3000-52","in 10mM Water","Others","Others","S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis.",135.18,"1187-84-4","<1","N/A",{"v":27,"d":"27.00"},199.73,"http://selleckchem.com/products/s-methyl-l-cysteine.html","C4H9NO2S","free base","S-Methylcysteine","CSCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4791","S-allyl-L-cysteine","c2","L3000-52","in 10mM Water","Others","Apoptosis","S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.",161.22,"21593-77-1","<1","N/A",{"v":32,"d":"32.00"},198.49,"http://selleckchem.com/products/s-allyl-l-cysteine.html","C6H11NO2S","free base","S-Allylcysteine","NC(CSCC=C)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4993","Timonacic","d2","L3000-52","in 10mM Water","Others","Others","Timonacic (Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid) is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities.",133.17,"444-27-9",{"v":1,"d":"1.00"},7.51,{"v":27,"d":"27.00"},202.75,"http://www.selleckchem.com/products/timonacic.html","C4H7NO2S","Free Base","Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid","OC(=O)C1CSCN1",-2.889,1,1,1]
["S5097","Methotrexate disodium","e2","L3000-52","in 10mM Water","Dehydrogenase,DHFR","Metabolism","Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.",{"v":498.4,"d":"498.40"},"7413-34-5","<1","N/A",{"v":99,"d":"99.00"},198.64,"http://selleckchem.com/products/methotrexate-disodium.html","C20H20N8O5.2Na","disodium salt","N/A","[Na+].[Na+].CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O",-2.834,5,3,9]
["S5131","Homotaurine","f2","L3000-52","in 10mM Water","GABA Receptor","Neuronal Signaling","Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.",139.17,"3687-18-1","N/A","N/A",{"v":27,"d":"27.00"},194.01,"http://selleckchem.com/products/homotaurine.html","C3H9NO3S","free base","Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid","NCCC[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S5136","Calcium folinate","g2","L3000-52","in 10mM Water","DHFR","Metabolism","Calcium folinate (Leucovorin calcium, Folinic acid calcium salt, Wellcovorin) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.",{"v":511.5,"d":"511.50"},"1492-18-8","<1","N/A",{"v":100,"d":"100.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/calcium-folinate.html","C20H21N7O7.Ca","calcium salt","Leucovorin calcium, Folinic acid calcium salt, Wellcovorin","[Ca++].NC1=NC(=C2N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)CNC2=N1)O",{"v":0,"d":"0.000"},0,0,0]
["S5137","O-Phospho-L-serine","h2","L3000-52","in 10mM Water","GluR","Neuronal Signaling","O-Phospho-L-serine (Dexfosfoserine), a molecule that mimics the phosphatidylserine head group and partially blocks microglial phagocytosis of apoptotic cells, is a specific group III metabotropic glutamate receptor (mGluR) agonist.",185.07,"407-41-0","<1","N/A",{"v":37,"d":"37.00"},199.92,"http://selleckchem.com/products/o-phospho-l-serine.html","C3H8NO6P","free base","Dexfosfoserine","NC(CO[P](O)(O)=O)C(O)=O",-4.121,2,1,4]
["S5267","Nylidrin Hydrochloride","a3","L3000-52","in 10mM Water","Adrenergic Receptor","Neuronal Signaling","Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.",335.87,"849-55-8","N/A",{"v":0,"d":"0.00"},{"v":67,"d":"67.00"},199.48,"https://www.selleckchem.com/products/nylidrin-hydrochloride.html","C19H25NO2.HCl","hydrochloride","Buphenine HCl","Cl.CC(CCC1=CC=CC=C1)NC(C)C(O)C2=CC=C(O)C=C2",4.112,0,3,7]
["S5384","UTP Trisodium Salt","b3","L3000-52","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.",550.09,"19817-92-6","<1","N/A",{"v":100,"d":"100.00"},181.79,"http://selleckchem.com/products/utp-trisodium-salt.html","C9H15N2O15P3.3Na","Trisodium salt","N/A","[Na+].[Na+].[Na+].OC1C(O)C(OC1CO[P]([O-])(=O)O[P]([O-])(=O)O[P](O)([O-])=O)N2C=CC(=O)NC2=O",-7.518,6,3,8]
["S5524","Spermine Tetrahydrochloride","c3","L3000-52","in 10mM Water","Others","Others","Spermine (Gerontine, Neuridine, Musculamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.",348.18,"306-67-2","<1","N/A",{"v":69,"d":"69.00"},198.17,"http://selleckchem.com/products/spermine-tetrahydrochloride.html","C10H26N4.4HCl","tetrahydrochloride","Gerontine tetrahydrochloride, Neuridine tetrahydrochloride, Musculamine tetrahydrochloride","Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN",0.024,0,4,11]
["S5526","β-Alanine","d3","L3000-52","in 10mM Water","Others","Others","β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors.",89.09,"107-95-9","<1","N/A",{"v":17,"d":"17.00"},190.82,"http://www.selleckchem.com/products/beta-alanine.html","C3H7NO2","Free Base","beta-Alanine, 3-Aminopropanoic acid","NCCC(O)=O",-3.397,1,1,2]
["S5533","Tobramycin sulfate","e3","L3000-52","in 10mM Water","Antibiotics,Bacterial","Microbiology","Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity.",1425.42,"49842-07-1","<1","N/A",{"v":100,"d":"100.00"},70.15,"https://www.selleckchem.com/products/tobramycin-sulfate.html","C36H84N10O38S5","free base","N/A","NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O.NCC4OC(OC5C(N)CC(N)C(OC6OC(CO)C(O)C(N)C6O)C5O)C(N)CC4O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-16.755,8,20,12]
["S5545","DL-Serine","f3","L3000-52","in 10mM Water","PKM","Metabolism","Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.",105.09,"302-84-1","<1","N/A",{"v":8,"d":"8.00"},76.13,"http://selleckchem.com/products/dl-serine.html","C3H7NO3","salt","N/A","NC(CO)C(O)=O",-4.049,1,2,2]
["S5572","Azetidine-2-carboxylic acid","g3","L3000-52","in 10mM Water","Others","Others","Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding.",{"v":101.1,"d":"101.10"},"2517-04-6","<1","N/A",{"v":20,"d":"20.00"},197.82,"http://selleckchem.com/products/azetidine-2-carboxylic-acid.html","C4H7NO2","free base","N/A","OC(=O)C1CCN1",-3.423,1,1,1]
["S5584","Citronellol","h3","L3000-52","in 10mM Water","Apoptosis related,Caspase,RIP kinase,ROS,TNF-alpha","Apoptosis","Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.",156.27,"106-22-9","<1","N/A",{"v":31,"d":"31.00"},198.37,"http://selleckchem.com/products/citronellol.html","C10H20O","free base","Dihydrogeraniol, (±)-β-Citronellol","CC(CCO)CCC=C(C)C",3.049,0,1,5]
["S5660","Clodronate disodium tetrahydrate","a4","L3000-52","in 10mM Water","Others","Others","Clodronate disodium tetrahydrate (clodronic acid) is a diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.",360.92,"88416-50-6","<1","N/A",{"v":72,"d":"72.00"},199.49,"https://www.selleckchem.com/products/clodronate-disodium-tetrahydrate.html","CH10Cl2Na2O10P2","free base","clodronic acid disodium tetrahydrate","O.O.O.O.[Na+].[Na+].O[P]([O-])(=O)C(Cl)(Cl)[P](O)([O-])=O",-2.534,0,0,2]
["S5706","Edetate Trisodium","b4","L3000-52","in 10mM Water","Others","Others","Edetate Trisodium (EDTA trisodium salt, ethylenediaminetetraacetic acid) is the organic sodium salt of ethylenediaminetetraacetic acid (EDTA). EDTA is a chelating agent capable of removing a heavy metal, such as lead or mercury, from the blood.",358.19,"150-38-9","<1","N/A",{"v":36,"d":"36.00"},100.51,"https://www.selleckchem.com/products/edetate-trisodium.html","C10H13N2Na3O8","free base","EDTA Trisodium, ethylenediaminetetraacetic acid Trisodium","[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O",-9.072,1,0,11]
["S6023","Creatine monohydrate","c4","L3000-52","in 10mM Water","Others","Others","Creatine (Methylguanidoacetic acid) is a key player in the phosphagen energy system, the primary source of ATP during short-term, high intensity activities.",149.15,"6020-87-7","N/A","N/A",5.96,39.94,"http://www.selleck.cn/products/creatine-monohydrate.html","C4H11N3O3","monohydrate","Methylguanidoacetic acid monohydrate","O.CN(CC(O)=O)C(N)=N",-1.302,1,1,3]
["S6129","Aminomalonic acid","d4","L3000-52","in 10mM Water","Others","Others","Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite.",119.08,"1068-84-4","N/A","N/A",{"v":11,"d":"11.00"},92.37,"http://www.selleck.cn/products/aminomalonic-acid.html","C3H5NO4","free base","Aminomalonate, Aminopropanedioic acid","NC(C(O)=O)C(O)=O",-3.815,2,1,2]
["S6334","DL-Norvaline","e4","L3000-52","in 10mM Water","Arginase","Immunology & Inflammation","DL-Norvaline (2-Aminopentanoic acid, H-DL-Nva-OH, 2-Aminovaleric acid, α-Aminopentanoic acid) is an important pharmaceutical intermediate.",117.15,"760-78-1","N/A","N/A",23.43,{"v":200,"d":"200.00"},"http://www.selleck.cn/products/dl-norvaline.html","C5H11NO2","free base","2-Aminopentanoic acid, H-DL-Nva-OH, 2-Aminovaleric acid, α-Aminopentanoic acid","CCCC(N)C(O)=O",-2.181,1,1,3]
["S6445","Chlorophyllin (sodium copper salt)","f4","L3000-52","in 10mM Water","Others","Others","Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent.",724.15,"11006-34-1","<1","N/A",{"v":13,"d":"13.00"},17.95,"http://www.selleck.cn/products/chlorophyllin.html","C34H31CuN4Na3O6","sodium copper salt","N/A","[Na+].[Na+].[Na+].[Cu++]|1|2|3|[N-]4C5=C(C)C(=C4C=C6N|1=C(C=C7[N-]|2C(=C(CC([O-])=O)C8=N|3C(=C5)C(C)C8CCC([O-])=O)C(=C7C)C([O-])=O)C(=C6C)CC)C=C",-1.452,0,0,8]
["S6488","Gadoxetate sodium","g4","L3000-52","in 10mM Water","Others","Others","Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection.",725.71,"135326-22-6","N/A","N/A",{"v":100,"d":"100.00"},{"v":137.8,"d":"137.80"},"http://www.selleck.cn/products/gadoxetate-sodium.html","C23H28GdN3Na2O11","sodium","N/A","[Na+].[Na+].[Gd+3]|1|2|3|4|5|6|7|[O-]C(=O)CN|1(CCN|2(CC([O-]|3)=O)CC([O-]|4)=O)CC(CC8=CC=C(OCC)C=C8)N|5(CC([O-]|6)=O)CC([O-]|7)=O",{"v":-3.48,"d":"-3.480"},1,0,4]
["S7204","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","h4","L3000-52","in 10mM Water","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.",440.29,"168555-66-6","<1","N/A",{"v":28,"d":"28.00"},63.59,"http://selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html","C18H19O8P.2Na","Disodium salt","CA 4DP","[Na+].[Na+].COC1=C(O[P]([O-])([O-])=O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",1.077,5,0,8]
["S7306","Dorsomorphin (Compound C) 2HCl","a5","L3000-52","in 10mM Water","AMPK,Autophagy,TGF-beta/Smad","PI3K/Akt/mTOR","Dorsomorphin 2HCl (BML-275, Compound C) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line.",472.41,"1219168-18-9","<1","N/A",{"v":94,"d":"94.00"},198.98,"http://selleckchem.com/products/dorsomorphin-2hcl.html","C24H25N5O.2HCl","Dihydrochloride","BML-275 2HCl,Compound C 2HCl","Cl.Cl.C1CCN(CC1)CCOC2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC=C5",3.792,4,0,6]
["S7362","AZD5582","b5","L3000-52","in 10mM Water","Apoptosis related,IAP","Apoptosis","AZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15",1015.29,"1258392-53-8","N/A","N/A",{"v":100,"d":"100.00"},98.49,"http://selleckchem.com/products/azd5582.html","C58H78N8O8","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3C(CC4=C3C=CC=C4)OCC#CC#CCOC5CC6=C(C=CC=C6)C5NC(=O)C7CCCN7C(=O)C(NC(=O)C(C)NC)C8CCCCC8",5.317,8,6,21]
["S7507","LDN-193189 2HCl","c5","L3000-52","in 10mM Water","TGF-beta/Smad","TGF-beta/Smad","LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.",{"v":479.4,"d":"479.40"},"1435934-00-1","<1","N/A",{"v":52,"d":"52.00"},108.47,"http://selleckchem.com/products/ldn-193189-2hcl.html","C25H24Cl2N6","Hydrochloride","DM-3189 2HCl","Cl.C1CN(CCN1)C2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC6=C5C=CC=C6",3.291,3,1,3]
["S7537","LB-100","d5","L3000-52","in 10mM Water","PP2A","PI3K/Akt/mTOR","LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.",268.31,"1026680-07-8","<1","N/A",{"v":53,"d":"53.00"},197.53,"http://selleckchem.com/products/lb-100.html","C13H20N2O4","free base","N/A","CN1CCN(CC1)C(=O)C2C3CCC(O3)C2C(O)=O",-3.624,3,0,2]
["S7547","XL413 (BMS-863233)","e5","L3000-52","in 10mM Water","CDK","Cell Cycle","XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.",326.18,"1169562-71-3","<1","N/A",{"v":46,"d":"46.00"},141.03,"http://selleckchem.com/products/xl413-bms-863233.html","C14H13Cl2N3O2","free base","N/A","Cl.ClC1=CC2=C(OC3=C2N=C(NC3=O)C4CCCN4)C=C1",2.537,3,2,1]
["S7785","Pemetrexed Disodium Hydrate","f5","L3000-52","in 10mM Water","Apoptosis related,Autophagy,DHFR","Metabolism","Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.",516.42,"357166-30-4","<1","N/A",{"v":100,"d":"100.00"},193.64,"http://selleckchem.com/products/pemetrexed-disodium-hydrate.html","C20H21N5O6.5/2H2O.2Na","Disodium Hydrate","LY-231514 Disodium Hydrate","NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O[Na])C(=O)O[Na])N1",{"v":2.06,"d":"2.060"},7,4,11]
["S7873","Disodium (R)-2-Hydroxyglutarate","g5","L3000-52","in 10mM Water","ROS","Immunology & Inflammation","Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.",192.08,"103404-90-6","<1","N/A",{"v":38,"d":"38.00"},197.83,"http://selleckchem.com/products/disodium-r-2-hydroxyglutarate.html","C5H6Na2O5","disodium salt","D-α-Hydroxyglutaric acid disodium","OC(CCC(=O)O[Na])C(=O)O[Na]",-0.509,4,1,6]
["S8008","RGD (Arg-Gly-Asp) Peptides","h5","L3000-52","in 10mM Water","Integrin","Cytoskeletal Signaling","RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.",346.34,"99896-85-2","<1","N/A",{"v":12,"d":"12.00"},34.65,"http://selleckchem.com/products/rgd-arg-gly-asp-peptides.html","C12H22N6O6","free base","N/A","NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC(O)=O)C(O)=O",-5.846,4,5,12]
["S8199","Ruxotemitide (LTX 315)","a6","L3000-52","in 10mM Water","Bcl-2","Apoptosis","Ruxotemitide (LTX 315, Oncopore) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.",1439.79,"1345407-05-7","N/A","N/A",{"v":100,"d":"100.00"},69.45,"http://selleckchem.com/products/ltx-315.html","C78H106N18O9","free base","Oncopore","NCCCCC(N)C(=O)NC(CCCCN)C(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC3=C[NH]C4=C3C=CC=C4)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC5=C[NH]C6=C5C=CC=C6)C(=O)NC(C(C7=CC=CC=C7)C8=CC=CC=C8)C(=O)NC(CCCCN)C(N)=O",3.102,9,18,46]
["S8442","TAK-659","b6","L3000-52","in 10mM Water","FLT3,Syk","Angiogenesis","TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.",380.85,"1952251-28-3","<1","N/A",{"v":4,"d":"4.00"},{"v":10.5,"d":"10.50"},"http://selleckchem.com/products/tak-659.html","C17H21FN6.HCl","hydrochloride","N/A","Cl.C[N]1C=C(C=N1)C2=C3C(=O)NCC3=C(F)C(=N2)NC4CCCCC4N",1.774,3,3,3]
["S8454","ATN-161 (Ac-PHSCN-NH2)","c6","L3000-52","in 10mM Water","Integrin","Cytoskeletal Signaling","ATN-161 (Ac-PHSCN-NH2) is  a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.",597.64,"262438-43-7","N/A","N/A",{"v":13,"d":"13.00"},21.75,"http://selleckchem.com/products/atn-161.html","C23H35N9O8S","free base","N/A","CC(=O)N1CCCC1C(=O)NC(CC2=C[NH]C=N2)C(=O)NC(CO)C(=O)NC(CS)C(=O)NC(CC(N)=O)C(N)=O",-5.261,8,8,15]
["S8501","Adaptavir (DAPTA)","d6","L3000-52","in 10mM Water","CCR","Immunology & Inflammation","Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.",856.88,"106362-34-9","N/A","N/A",{"v":100,"d":"100.00"},{"v":116.7,"d":"116.70"},"http://selleckchem.com/products/dapta.html","C35H56N10O15","free base","D-Ala-peptide T-amide, peptide T","CC(N)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(C(C)O)C(N)=O",-7.366,9,16,24]
["S8549","AUNP-12","e6","L3000-52","in 10mM Water","PD-1/PD-L1","Immunology & Inflammation","AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.",3261.55,"1353563-85-5","N/A","N/A",{"v":100,"d":"100.00"},30.66,"http://selleckchem.com/products/aunp-12.html","C142H226N40O48","free base","Aur-012, Aurigene-012, Aurigene NP-12","CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCC(O)=O)NN)C(=O)NC(CCC(N)=O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C)C(=O)C(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCNNC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C=O)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(N)CO)C(C)O)C(C)C)C(C)O",-25.604,36,47,115]
["S8651","bpV (HOpic)","f6","L3000-52","in 10mM Water","PTEN","PI3K/Akt/mTOR","bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.",347.24,"722494-26-0","<1","N/A",{"v":69,"d":"69.00"},198.71,"http://selleckchem.com/products/bpv-hopic.html","C6H4NO8V.2K","potassium","Bisperoxovanadium (HOpic)","[K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O",-1.876,0,1,0]
["S8674","GO-203","g6","L3000-52","in 10mM Water","Others","Metabolism","GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.",2426.77,"1222186-26-6","N/A","N/A",{"v":100,"d":"100.00"},41.21,"http://selleckchem.com/products/go-203.html","C87H170N52O19S2.C2HF3O2","trifluoroacetate","N/A","NCCCCC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CS)NC(=O)C(CCC(N)=O)NC(=O)C(CS)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC(N)=O)C(O)=O.OC(=O)C(F)(F)F",-21.045,19,41,98]
["S9353","L-serine","h6","L3000-52","in 10mM Water","Others","Others","L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.",105.09,"56-45-1","N/A",{"v":0,"d":"0.00"},{"v":21,"d":"21.00"},199.82,"https://www.selleckchem.com/products/l-serine.html","C3H7NO3","free base","N/A","NC(CO)C(O)=O",-4.049,1,2,2]
["P1011","Eptifibatide Acetate","a7","L3000-52","in 10mM Water","5-alpha Reductase","Angiogenesis","Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.",{"v":832.4,"d":"832.40"},"148031-34-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/eptifibatide-acetate.html","C35H49N11O9S2","Acetate","Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2","NC(=N)NCCCCC1NC(=O)CCSSCC(NC(=O)C2CCCN2C(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC(=O)C(CC(O)=O)NC(=O)CNC1=O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["P1017","Octreotide (SMS 201-995) acetate","b7","L3000-52","in 10mM Water","N/A","Neuronal Signaling","Octreotide (SMS 201-995) acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.","1019.28 (free base)","79517-01-4","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/octreotide-acetate.html","C49H66N10O10S2.xC2H4O2","Acetate","D-Phe-c[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol","CC(O)C(CO)NC(=O)C1CSSCC(NC(=O)C(N)CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=C[NH]C5=C4C=CC=C5)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)N1",{"v":0,"d":"0.000"},0,0,0]
["P1025","Atosiban Acetate","c7","L3000-52","in 10mM Water","N/A","Angiogenesis","Atosiban Acetate is a competitive oxytocin and vasopressin antagonist by exhibiting high affinity for both receptors. It is used to treat preterm labors.",{"v":994.2,"d":"994.20"},"90779-69-4","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/peptide/atosiban-acetate.html","C43H67N11O12S2","Acetate","c[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2","CCOC1=CC=C(CC2NC(=O)CCSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(NC2=O)C(C)CC)C(C)O)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(N)=O)C=C1",{"v":0,"d":"0.000"},0,0,0]
["P1030","Salmon Calcitonin Acetate","d7","L3000-52","in 10mM Water","N/A","N/A","Salmon Calcitonin Acetate, which is more potent and longer lasting than human CT, has been used widely for the treatment of osteoporosis, paget's disease, hypercalcemic shock and chronic pain in terminal cancer patients.",3431.85,"47931-85-1","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/peptide/salmon-calcitonin-acetate.html","C145H240N44O48S2","Acetate","N/A","CC(C)CC(NNC(CCC(N)=O)C(=O)NC(C(C)O)C(=O)C(=O)C(CC1=CC=C(O)C=C1)NN2CCCC2C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N3CCCC3C(N)=O)C(=O)C(=O)C(CCCCN)NC(=O)C(CC4=CN=C[NH]4)NC(=O)C(CC(C)C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(NC(=O)C5CSSCC(N)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)N5)C(C)C",{"v":0,"d":"0.000"},0,0,0]
["P1039","Somatostatin Acetate","e7","L3000-52","in 10mM Water","5-alpha Reductase","Neuronal Signaling","Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.",1637.88,"38916-34-6",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},61.05,"http://www.selleck.cn/products/somatostatin-acetate.html","C76H104N18O19S2","Free Base","Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(Cys3-Cys14)","CC(N)C(=O)NCC(=O)NC1CSSCC(NC(=O)C(CO)NC(=O)C(NC(=O)C(CC2=CC=CC=C2)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC1=O)C(C)O)C(C)O)C(O)=O.CC(O)=O",-8.729,16,21,26]
["P1084","Desmopressin Acetate","f7","L3000-52","in 10mM Water","Vasopressin Receptor","GPCR & G Protein","Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).",1129.27,"62288-83-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/desmopressin-acetate-.html","C46H64N14O12S2.C2H4O2","Acetate","N/A","CC(O)=O.NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)C2CSSCCC(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O",{"v":0,"d":"0.000"},0,0,0]
["P1085","Angiotensin II human Acetate","g7","L3000-52","in 10mM Water","Angiotensin Receptor","GPCR & G Protein","Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.",1106.23,"68521-88-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/angiotensin-ii-human-acetate.html","C52H75N13O14","Acetate","N/A","CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC2=C[NH]C=N2)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(O)=O.CC(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S1671","(6-)ε-​Aminocaproic acid","h7","L3000-52","in 10mM Water","Others","Others","(6-)ε-​Aminocaproic acid is a derivative and analogue of the amino acid lysine.",131.17,"60-32-2","N/A","N/A",{"v":26,"d":"26.00"},198.22,"http://selleckchem.com/products/Aminocaproic-acid(Amicar).html","C6H13NO2","free base","N/A","NCCCCCC(O)=O",-2.164,1,1,5]
["S3076","Foscarnet Sodium","a8","L3000-52","in 10mM Water","Reverse Transcriptase","Microbiology","Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.",191.95,"63585-09-1","N/A","N/A",{"v":3,"d":"3.00"},15.63,"http://selleckchem.com/products/foscarnet-sodium.html","CNa3O5P","Sodium","Phosphonoformate","[Na+].[Na+].[Na+].[O-]C(=O)[P]([O-])([O-])=O",-4.033,0,0,1]
["S4519","Citric acid trilithium salt tetrahydrate","b8","L3000-52","in 10mM Water","Others","Others","Citric acid trilithium salt tetrahydrate (Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material. It is commonly used in HPLC gradient elution for quantification of amino acids.",281.98,"6080-58-6","N/A","N/A",{"v":56,"d":"56.00"},{"v":198.6,"d":"198.60"},"http://selleckchem.com/products/citric-acid-trilithium-salt-tetrahydrate.html","C6H5Li3O7&bull;4H2O","free base","Trilithium citrate tetrahydrate, Lithium citrate tribasic tetrahydrate","O.O.O.O.[Li]OC(=O)CC(O)(CC(=O)O[Li])C(=O)O[Li]",-1.875,6,0,8]
["S2441","Estramustine phosphate sodium","c8","L3000-52","in 10mM Water","Microtubule Associated","Cytoskeletal Signaling","Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.",564.35,"52205-73-9","<1","N/A",{"v":100,"d":"100.00"},{"v":177.2,"d":"177.20"},"http://www.selleck.cn/products/estramustine-phosphate-sodium.html","C23H30Cl2NNa2O6P","phosphate sodium","EMP, Emcyt, Estracyt","[Na+].[Na+].CC12CCC3C(CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl)C1CCC2O[P]([O-])([O-])=O",3.131,3,0,8]
["S8670","Vipivotide tetraxetan (PSMA-617)","d8","L3000-52","in 10mM Water","Drug-Linker Conjugates for ADC","Others","Vipivotide tetraxetan (PSMA-617) is a chemically modified PSMA(prostate-specific membrane antigen) inhibitor with a Ki of 0.37 nM.",1042.14,"1702967-37-0",{"v":-1,"d":"-1.00"},-0.96,{"v":100,"d":"100.00"},95.96,"http://www.selleckchem.com/products/vipivotide-tetraxetan.html","C49H71N9O16","Free Base","N/A","OC(=O)CCC(NC(=O)NC(CCCCNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C3CCC(CC3)CNC(=O)CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)C(O)=O",-11.549,10,5,27]
["S6894","BCH","e8","L3000-52","in 10mM Water","Amino acid transporter,Apoptosis related","Transmembrane Transporters","BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.",155.19,"20448-79-7",{"v":1,"d":"1.00"},6.44,{"v":31,"d":"31.00"},199.76,"http://www.selleckchem.com/products/bch.html","C8H13NO2","free base","2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1","NC1(CC2CCC1C2)C(O)=O",-1.974,1,1,1]
["S8620","6-Diazo-5-oxo-L-norleucine","f8","L3000-52","in 10mM Water","Glutaminase","Proteases","6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1  mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.",171.15,"157-03-9","<1","N/A",{"v":34,"d":"34.00"},198.66,"http://www.selleckchem.com/products/6-diazo-5-oxo-l-norleucine.html","C6H9N3O3","free base","Diazooxonorleucine, 6-Diazo-5-oxo-L-nor-Leucine, L-6-Diazo-5-oxonorleucine, DON","NC(CCC(=O)C=[N+]=[N-])C(O)=O",-3.117,2,1,5]
["S9665","Motixafortide (BL-8040)","g8","L3000-52","in 10mM Water","Apoptosis related,Bcl-2,CDK,CXCR,ERK,MicroRNA","Immunology & Inflammation","Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.",2159.52,"664334-36-5",{"v":-1,"d":"-1.00"},-0.46,{"v":100,"d":"100.00"},46.31,"http://www.selleckchem.com/products/motixafortide-bl-8040-.html","C97H144FN33O19S2","free base","BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140","NCCCCC1NC(=O)C(CCCNC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CSSCC(NC(=O)C(CCCNC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C4CCCN4C(=O)C(CCCCN)NC1=O)C(=O)NC(CCCNC(N)=N)C(N)=O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C7=CC=C(F)C=C7",-3.895,17,30,53]
["P1088","Lanreotide acetate","h8","L3000-52","in 10mM Water","GHSR","Endocrinology & Hormones","Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate, an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.",1156.38,"2378114-72-6",{"v":-1,"d":"-1.00"},"N/A",{"v":23,"d":"23.00"},19.89,"https://www.selleckchem.com/products/lanreotide-acetate.html","C56H73N11O12S2","Acetate","Laromustine, Angiopeptin, BIM 23014, BIM 23014C, BM 23014, Dermopeptin, Ipstyl, ITM-014, ITM-014T, Somatulina, Somatuline, Lanreotidum","CC(C)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(C(C)O)C(N)=O)NC(=O)C(N)CC5=CC6=CC=CC=C6C=C5.CC(O)=O",-0.979,9,13,17]
["S1325","L-2-Hydroxyglutaric acid disodium","a9","L3000-52","in 10mM Water","Histone Demethylase","Epigenetics","L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.",192.08,"63512-50-5","<1","N/A",{"v":38,"d":"38.00"},197.83,"https://www.selleckchem.com/products/l-2-hydroxyglutaric-acid-disodium.html","C5H6Na2O5","Disodium","(S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG","[Na+].[Na+].OC(CCC([O-])=O)C([O-])=O",-3.639,0,1,4]
["S2996","L-DAB HBR","b9","L3000-52","in 10mM Water","GABA Receptor","Neuronal Signaling","L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity.",199.05,"73143-97-2","<1","N/A",{"v":23,"d":"23.00"},{"v":194.7,"d":"194.70"},"https://www.selleckchem.com/products/ldab-hbr.html","C4H11BrN2O2","Hydrobromide","L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide","Br.NCCC(N)C(O)=O",-3.786,1,2,3]
["S3096","L-Histidine monohydrochloride monohydrate","c9","L3000-52","in 10mM Water","Others","Metabolism","L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.",209.63,"5934-29-2","<1","N/A",{"v":42,"d":"42.00"},200.35,"https://www.selleckchem.com/products/l-histidine-monohydrochloride-monohydrate.html","C6H12ClN3O3","Monohydrate","L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O","O.Cl.NC(CC1=CN=C[NH]1)C(O)=O",-3.538,2,2,3]
["S3346","1-Methylnicotinamide chloride","d9","L3000-52","in 10mM Water","Prostaglandin Receptor","GPCR & G Protein","1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.",172.61,"1005-24-9","<1","N/A",{"v":35,"d":"35.00"},202.77,"https://www.selleckchem.com/products/1-methylnicotinamide-chloride.html","C7H9ClN2O","Chloride","1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium chloride, Trigonellamide chloride","[Cl-].C[N+]1=CC=CC(=C1)C(N)=O",-2.237,1,1,1]
["S8415","PACAP 1-38","e9","L3000-52","in 10mM Water","cAMP","GPCR & G Protein","PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.",4534.26,"137061-48-4",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},22.05,"https://www.selleckchem.com/products/pacap-1-38.html","C203H331N63O53S","Free Base","Pituitary Adenylate Cyclase Activating Polypeptide 38","CCC(C)C(NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=C[NH]1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=CC=C(O)C=C4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)C(=O)C(CC5=CC=C(O)C=C5)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC6=CC=C(O)C=C6)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NN)C(C)C)C(C)C",-21.727,44,66,164]
["S9728","BSO (L-Buthionine-(S,R)-sulfoximine)","f9","L3000-52","in 10mM Water","γGCS","Metabolism","BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine, l-BSO) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.",222.31,"83730-53-4","<1","N/A",{"v":40,"d":"40.00"},179.93,"https://www.selleckchem.com/products/bso-l-buthionine-s-r-sulfoximine.html","C8H18N2O3S","Free Base","L-Buthionine sulfoximine, l-BSO","CCCC[S](=N)(=O)CCC(N)C(O)=O",{"v":-2.18,"d":"-2.180"},2,1,7]
["P1202","TMPyP4 tosylate","g9","L3000-52","in 10mM Water","G-quadruplex,Telomerase","DNA Damage/DNA Repair","TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.",{"v":1363.6,"d":"1363.60"},"36951-72-1",{"v":-1,"d":"-1.00"},"N/A",{"v":50,"d":"50.00"},36.67,"http://www.selleckchem.com/products/tmpyp4-tosylate.html","C72H66N8O12S4","Tosylate","TMP 1363","CC1=CC=C(C=C1)[S]([O-])(=O)=O.CC2=CC=C(C=C2)[S]([O-])(=O)=O.CC3=CC=C(C=C3)[S]([O-])(=O)=O.CC4=CC=C(C=C4)[S]([O-])(=O)=O.C[N+]5=CC=C(C=C5)C6=C7C=CC(=N7)C(=C8[NH]C(=C(C9=CC=[N+](C)C=C9)C%10=NC(=C(C%11=CC=C6[NH]%11)C%12=CC=[N+](C)C=C%12)C=C%10)C=C8)C%13=CC=[N+](C)C=C%13",7.273,2,2,8]
["S1314","Zoledronic acid (ZOL 446)","h9","L3000-52","in 10mM Water","Apoptosis related,Autophagy,Ras,Rho","Cell Cycle","Zoledronic acid (ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast), a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. Zoledronic acid (ZA) also induces autophagy.",272.09,"118072-93-8","<1","N/A",{"v":4,"d":"4.00"},{"v":14.7,"d":"14.70"},"http://www.selleckchem.com/products/Zoledronic-Acid.html","C5H10N2O7P2","Free Base","ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast","OC(C[N]1C=CN=C1)([P](O)(O)=O)[P](O)(O)=O",-1.209,1,0,4]
["S6289","Gentamicin","a10","L3000-52","in 10mM Water","Antiviral","Microbiology","Gentamicin, an aminoglycoside class of bactericidal antibiotic, is effective against gram-negative bacterial infections.",1390.71,"1403-66-3","<1","N/A",{"v":100,"d":"100.00"},71.91,"http://www.selleckchem.com/products/gentamicin.html","C60H123N15O21","free base","N/A","CNC(C)C1CCC(N)C(O1)OC2C(N)CC(N)C(OC3OCC(C)(O)C(NC)C3O)C2O.CNC4C(O)C(OCC4(C)O)OC5C(N)CC(N)C(OC6OC(CN)CCC6N)C5O.CNC7C(O)C(OCC7(C)O)OC8C(N)CC(N)C(OC9OC(CCC9N)C(C)N)C8O",-12.679,12,21,19]
["S6872","Merbromin","b10","L3000-52","in 10mM Water","3C-Like Protease,Bacterial","Proteases","Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro.",752.68,"129-16-8","<1","N/A",{"v":100,"d":"100.00"},132.86,"http://www.selleckchem.com/products/merbromin.html","C20H10Br2HgO6.2Na","free base","Mercurochrome, Merbromine, Mercurocol, Sodium mercurescein, Asceptichrome, Supercrome, Brocasept, Cinfacromin","[NaH].[NaH].O[Hg]C1=C(O)C(=CC2=C1OC3=CC(=C(Br)C=C3C24OC(=O)C5=C4C=CC=C5)O)Br",4.622,3,2,1]
["E0532","Menotropin","c10","L3000-52","in 10mM Water","Estrogen/progestogen Receptor","Endocrinology & Hormones","Menotropin (Human Menopausal Gonadotrophin) is a hormonally active medication for the treatment of fertility disturbances, which are extracted from the urine of postmenopausal women.",142.24,"61489-71-2","<1","N/A",{"v":28,"d":"28.00"},196.85,"http://www.selleckchem.com/products/menotropin.html","C9H18O","free base","Human Menopausal Gonadotrophin","CC(C)(C)CCCCC=O",2.767,1,0,5]
["E0654","D-Arginine","d10","L3000-52","in 10mM Water","Decarboxylase","Metabolism","D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.",{"v":174.2,"d":"174.20"},"157-06-2","<1","N/A",{"v":35,"d":"35.00"},200.92,"http://www.selleckchem.com/products/d-arginine.html","C6H14N4O2","free base","N/A","NC(CCCN=C(N)N)C(O)=O",-3.831,2,3,5]
["E2638","Tricine","e10","L3000-52","in 10mM Water","Others","Others","Tricine (N-[Tris(hydroxymethyl)methyl]glycine) is a buffer component for separation of low molecular weight peptides.",179.17,"5704-04-1","<1","N/A",{"v":36,"d":"36.00"},200.93,"http://www.selleckchem.com/products/tricine.html","C6H13NO5","free base","N-[Tris(hydroxymethyl)methyl]glycine","OCC(CO)(CO)NCC(O)=O",-5.173,1,4,6]
["E2688","Glufosinate-ammonium","f10","L3000-52","in 10mM Water","Others","Others","Glufosinate-ammonium (Glufosinate ammonium), a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin), exerting neurotoxic activity.",198.16,"77182-82-2","<1","N/A",{"v":40,"d":"40.00"},201.86,"http://www.selleckchem.com/products/glufosinate-ammonium.html","C5H12NO4P.H3N","ammonium salt","Glufosinate ammonium","N.C[P](O)(=O)CCC(N)C(O)=O",-3.595,2,1,4]
["E2830","Cyclocreatine","g10","L3000-52","in 10mM Water","Others","Others","Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by preserving high levels of ATP.",143.14,"35404-50-3","<1","N/A",{"v":7,"d":"7.00"},{"v":48.9,"d":"48.90"},"http://www.selleckchem.com/products/cyclocreatine.html","C5H9N3O2","free base","N/A","NC1=NCCN1CC(O)=O",{"v":-1.07,"d":"-1.070"},2,1,2]
["P1137","Thymulin","h10","L3000-52","in 10mM Water","CCR,Interleukins","Immunology & Inflammation","Thymulin (FTS) is a neuroendocrine hormone with immunoregulatory actions, with anti-inflammatory potential by downregulating the release of inflammatory mediators, such as cytokines and chemokines, upregulating anti-inflammatory factors, such as interleukin (IL)-10, exerting molecular control via the regulation of transcription factors and mediators.",858.85,"63958-90-7","<1","N/A",{"v":100,"d":"100.00"},116.43,"http://www.selleckchem.com/products/thymulin.html","C33H54N12O15","free base","FTS","CC(NC(=O)C1CCC(=O)N1)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CC(N)=O)C(O)=O",-11.877,12,14,28]
["P1213","gp91ds-tat","a11","L3000-52","in 10mM Water","NADPH-oxidase","Others","gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.",{"v":2673.3,"d":"2673.30"},"N/A",{"v":-1,"d":"-1.00"},-0.37,{"v":49,"d":"49.00"},18.33,"http://www.selleckchem.com/products/gp91ds-tat.html","C109H202N52O25S1","free base","N/A","CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CO)NC(=O)C(CS)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(N)CCCNC(N)=N)C(C)O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(N)=O",-15.881,20,43,101]
["S8164","YAP-TEAD Inhibitor 1 (Peptide 17)","b11","L3000-52","in 10mM Water","TEAD,YAP","Hippo","YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.",2019.86,"1659305-78-8","<1","N/A",{"v":100,"d":"100.00"},49.51,"http://www.selleckchem.com/products/yap-tead-inhibitor-1-peptide-17.html","C93H144ClN23O21S2","Free base","N/A","CCCCC1NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCSSCC(NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(C)NC(=O)C3CCCN3C1=O)C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCC(O)=O)C(N)=O)NC(=O)C(CC6=CC(=CC=C6)Cl)NC(=O)C7CCCN7C(=O)C(NC(C)=O)C(C)C",{"v":-4.13,"d":"-4.130"},19,19,40]
["S8197","APTSTAT3-9R","c11","L3000-52","in 10mM Water","STAT","JAK/STAT","APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.",4947.51,"N/A","<1","N/A",{"v":98,"d":"98.00"},19.81,"http://www.selleckchem.com/products/aptstat3-9r.html","C223H330N80O51","Free base","N/A","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(NC(=O)C(CC5=C[NH]C6=CC=CC=C56)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC7=C[NH]C8=CC=CC=C78)NC(=O)C(NC(=O)C(CC9=C[NH]C%10=CC=CC=C9%10)NC(=O)C(CO)NC(=O)CNC(=O)C%11CCCN%11C(=O)C(CC%12=C[NH]C%13=CC=CC=C%12%13)NC(=O)C(CCC(N)=O)NC(=O)C(CC%14=CC=CC=C%14)NC(=O)CNC(=O)C(N)CC%15=C[NH]C=N%15)C(C)O)C(C)O)C(=O)NC(CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(O)=O",-24.945,45,74,170]
["S8416","PACAP 6-38","d11","L3000-52","in 10mM Water","cAMP","GPCR & G Protein","PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.",4024.74,"143748-18-9","<1","N/A",{"v":100,"d":"100.00"},24.85,"http://www.selleckchem.com/products/pacap-6-38.html","C182H300N56O45S","Free base","N/A","CSCCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(N)CC3=CC=CC=C3)C(C)O)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC4=CC=C(O)C=C4)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC5=CC=C(O)C=C5)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(N)=O",{"v":-15.97,"d":"-15.970"},37,59,146]
["S8505","LY2510924","e11","L3000-52","in 10mM Water","CXCR","Immunology & Inflammation","LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0.38 nmol/L.",1189.45,"1088715-84-7","<1","N/A",{"v":100,"d":"100.00"},84.07,"http://www.selleckchem.com/products/ly2510924.html","C62H88N14O10","Free base","N/A","CC(C)NCCCCC(NC(=O)C1CCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CCCCNC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=CC5=C(C=CC=C5)C=C4)C(=O)NCC(=O)N1)C(N)=O",1.764,9,14,26]
["S9725","Balixafortide (POL6326)","f11","L3000-52","in 10mM Water","CXCR","Immunology & Inflammation","Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.",1864.11,"1051366-32-5","<1","N/A",{"v":100,"d":"100.00"},53.64,"http://www.selleckchem.com/products/balixafortide-pol6326.html","C84H118N24O21S2","Free base","N/A","CC1NNC(CC2=CN=C[NH]2)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC7CSSCC(NC1=O)C(=O)NC(CO)C(=O)NC(C)C(=O)N8CCCC8C(=O)NC(CCN)C(=O)NC(CCCNC(N)=N)C(=O)C(=O)C(CC9=CC=C(O)C=C9)NC7=O",-6.059,18,23,23]
["E1223","RGX-202","g11","L3000-52","in 10mM Water","Apoptosis related","Metabolism","RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo.",131.13,"353-09-3","<1","N/A",{"v":26,"d":"26.00"},198.28,"https://www.selleckchem.com/products/rgx-202.html","C4H9N3O2","Free base","N/A","NC(=N)NCCC(O)=O",-1.052,1,2,4]
["S5961","Prednisolone disodium phosphate","h11","L3000-52","in 10mM Water","Anti-infection","Microbiology","Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.",484.39,"125-02-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/products/prednisolone-disodium-phosphate.html","C21H27Na2O8P","Phosphate","Hydeltrasol, Prednisolone 21-phosphate disodium","[Na+].[Na+].CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO[P]([O-])([O-])=O",-0.989,3,1,4]
["E1723","NSC16168","a2","L3000-53","in 10mM Water","Others","Others","NSC16168 is a specific inhibitor of ERCC1-XPF, and exhibits an IC50 value of 0.42 μM in a high throughput screen (HTS) assay, respectively. NSC16168 inhibits DNA repair and potentiates cisplatin efficacy in cancer.",{"v":473.5,"d":"473.50"},"6837-93-0",{"v":4,"d":"4.00"},8.45,{"v":95,"d":"95.00"},200.63,"https://www.selleckchem.com/products/nsc16168.html","C17H15NO9S3","Free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)OC2=CC(=CC3=C2C(=CC(=C3)[S](O)(=O)=O)N)[S](O)(=O)=O",2.278,1,1,5]
["S2542","Phenformin (NSC-756501) HCl","b2","L3000-53","in 10mM Water","AMPK","PI3K/Akt/mTOR","Phenformin HCl (NSC-756501, Phenethylbiguanide) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.",241.72,"834-28-6","N/A","N/A","N/A",">10","http://selleckchem.com/products/Phenformin-hydrochloride.html","C10H15N5.HCl","Hydrochloride","Phenethylbiguanide HCl","Cl.NC(=N)NC(=N)NCCC1=CC=CC=C1",1.339,0,3,6]
["S1019","Canertinib (CI-1033)","a2","L3000-54","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Canertinib (CI-1033, PD183805) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.",485.94,"267243-28-7",{"v":2,"d":"2.00"},4.12,"<1","N/A","http://selleckchem.com/products/CI-1033(Canertinib).html","C24H25ClFN5O3","Free Base","PD183805","FC1=C(Cl)C=C(NC2=NC=NC3=CC(=C(NC(=O)C=C)C=C23)OCCCN4CCOCC4)C=C1",4.037,5,2,9]
["S1023","Erlotinib (OSI-774) HCl","b2","L3000-54","in 2mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781) HCl is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.",{"v":429.9,"d":"429.90"},"183319-69-9",{"v":4,"d":"4.00"},{"v":9.3,"d":"9.30"},"<1","N/A","http://selleckchem.com/products/Erlotinib-Hydrochloride.html","C22H23N3O4.HCl","Hydrochloride","CP358774, NSC 718781,OSI-774 HCl","Cl.COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.691,6,1,10]
["S1043","Tandutinib (MLN518)","c2","L3000-54","in 2mM DMSO","FLT3","Angiogenesis","Tandutinib (MLN518, CT53518, NSC726292) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.",{"v":562.7,"d":"562.70"},"387867-13-2",{"v":5,"d":"5.00"},8.89,"<1","N/A","http://selleckchem.com/products/Tandutinib-(MLN518).html","C31H42N6O4","Free Base","CT 53518, NSC726292, MLN518","COC1=CC2=C(C=C1OCCCN3CCCCC3)N=CN=C2N4CCN(CC4)C(=O)NC5=CC=C(OC(C)C)C=C5",4.674,6,1,10]
["S1046","Vandetanib (ZD6474)","d2","L3000-54","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1108","TAE684 (NVP-TAE684)","e2","L3000-54","in 2mM DMSO","ALK,Apoptosis related","Protein Tyrosine Kinase","TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.",{"v":614.2,"d":"614.20"},"761439-42-3",{"v":3,"d":"3.00"},4.88,"<1","N/A","http://selleckchem.com/products/NVP-TAE684.html","C30H40ClN7O3S","Free Base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.342,5,2,9]
["S1112","SGX-523","f2","L3000-54","in 2mM DMSO","c-Met","Protein Tyrosine Kinase","SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1.",359.41,"1022150-57-7",{"v":3,"d":"3.00"},8.35,"<1","N/A","http://selleckchem.com/products/SGX-523.html","C18H13N7S","free base","N/A","C[N]1C=C(C=N1)C2=N[N]3C(=NN=C3C=C2)SC4=CC=C5N=CC=CC5=C4",{"v":3.58,"d":"3.580"},5,0,3]
["S1118","XL147 analogue","g2","L3000-54","in 2mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2.",448.52,"956958-53-5",{"v":3,"d":"3.00"},6.69,"<1","N/A","http://selleckchem.com/products/XL147.html","C21H16N6O2S2","Free Base","SAR245408","CC1=CC=C(C=C1)[S](=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4",5.024,6,2,5]
["S1205","PIK-75 HCl","h2","L3000-54","in 2mM DMSO","DNA-PK,PI3K","PI3K/Akt/mTOR","PIK-75 HCl is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.",488.74,"372196-77-5",{"v":4,"d":"4.00"},8.18,"<1","N/A","http://selleckchem.com/products/PIK-75-Hydrochloride.html","C16H14BrN5O4S.HCl","Hydrochloride","N/A","Cl.CN(/N=C/C1=CN=C2C=CC(=C[N]12)Br)[S](=O)(=O)C3=C(C)C=CC(=C3)[N+]([O-])=O",3.272,4,0,5]
["S1211","Imiquimod (R-837)","a3","L3000-54","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Imiquimod (Aldara,R-837,S-26308) is a novel synthetic agent with immune response modifying activity.",{"v":240.3,"d":"240.30"},"99011-02-6",{"v":1,"d":"1.00"},4.16,"<1","N/A","http://selleckchem.com/products/Imiquimod.html","C14H16N4","free base","Aldara,R-837, S-26308","CC(C)C[N]1C=NC2=C(N)N=C3C=CC=CC3=C12",2.722,2,1,2]
["S1288","Camptothecin (NSC-100880)","b3","L3000-54","in 2mM DMSO","ADC Cytotoxin,Apoptosis related,MicroRNA,Topoisomerase","DNA Damage/DNA Repair","Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.",348.35,"7689-03-4",{"v":3,"d":"3.00"},8.61,"<1","N/A","http://selleckchem.com/products/Camptothecine.html","C20H16N2O4","Free Base","CPT, Campathecin, (S)-(+)-Camptothecin","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=CC5=C4)C2=O",1.746,4,0,1]
["S1327","Ellagic acid","c3","L3000-54","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property.",302.19,"476-66-4",{"v":3,"d":"3.00"},9.93,"<1","N/A","http://selleckchem.com/products/Ellagic-acid.html","C14H6O8","free base","Elagostasine, Gallogen","OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S1353","Ketoconazole (R 41400)","d3","L3000-54","in 2mM DMSO","Androgen Receptor,Fungal,P450 (e.g. CYP17)","Metabolism","Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.",531.43,"65277-42-1",{"v":5,"d":"5.00"},9.41,"<1","N/A","http://selleckchem.com/products/Ketoconazole.html","C26H28Cl2N4O4","free base","R 41400","CC(=O)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=CN=C4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",{"v":3.61,"d":"3.610"},5,0,7]
["S1360","GSK1059615","e3","L3000-54","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Phase 1.",333.36,"958852-01-2",{"v":2,"d":"2.00"},{"v":6,"d":"6.00"},"<1","N/A","http://selleckchem.com/products/GSK1059615.html","C18H11N3O2S","Free Base","N/A","O=C1NC(=O)/C(S1)=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2",2.496,4,1,2]
["S1424","Prazosin HCl","f3","L3000-54","in 2mM DMSO","Adrenergic Receptor","GPCR & G Protein","Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.",419.86,"19237-84-4",{"v":4,"d":"4.00"},9.53,"<1","N/A","http://selleckchem.com/products/Prazosin-hydrochloride.html","C19H21N5O4.HCl","Hydrochloride","cp-12299-1","Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N",2.489,6,1,4]
["S1463","Ofloxacin","g3","L3000-54","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ofloxacin (DL8280) is a synthetic broad-spectrum antimicrobial agent.",361.37,"82419-36-1",{"v":1,"d":"1.00"},2.77,"<1","N/A","http://www.selleck.cn/products/Ofloxacin(Floxin).html","C18H20FN3O4","Free Base","DL8280","CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F",-1.374,3,0,2]
["S1464","Marbofloxacin","h3","L3000-54","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.",362.36,"115550-35-1",{"v":3,"d":"3.00"},8.28,"<1","N/A","http://selleckchem.com/products/Marbofloxacin.html","C17H19FN4O4","free base","N/A","CN1CCN(CC1)C2=C(F)C=C3C(=O)C(=CN4N(C)COC2=C34)C(O)=O",-2.038,3,0,2]
["S1507","Irbesartan","a4","L3000-54","in 2mM DMSO","Angiotensin Receptor","GPCR & G Protein","Irbesartan (BMS-186295, SR-47436,APROVEL) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.",428.53,"138402-11-6",{"v":4,"d":"4.00"},9.33,"<1","N/A","http://selleckchem.com/products/Irbesartan(Avapro).html","C25H28N6O","free base","BMS-186295, SR-47436,APROVEL","CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5",{"v":0,"d":"0.000"},0,0,0]
["S1509","Norfloxacin","b4","L3000-54","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Norfloxacin (MK-0366) is a broad-spectrum antibiotic. Norfloxacin (MK-0366) targets bacterial gyrase and topoisomerase IV enzymes.",319.33,"70458-96-7",{"v":3,"d":"3.00"},9.39,"<1","N/A","http://selleckchem.com/products/Norfloxacin(Norxacin).html","C16H18FN3O3","free base","MK-0366","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(C=C12)N3CCNCC3)F",{"v":0,"d":"0.000"},0,0,0]
["S1519","CCT129202","c4","L3000-54","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.",497.02,"942947-93-5",{"v":3,"d":"3.00"},6.04,"<1","N/A","http://selleckchem.com/products/CCT129202.html","C23H25ClN8OS","Free Base","N/A","CN(C)C1=CC=C(C=C1)C2=NC3=C(N4CCN(CC4)CC(=O)NC5=NC=CS5)C(=CN=C3[NH]2)Cl",2.898,4,2,6]
["S1615","Risperidone","d4","L3000-54","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Risperidone (R-64766) is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.",410.48,"106266-06-2",{"v":4,"d":"4.00"},9.74,"<1","N/A","http://selleckchem.com/products/Risperidone(Risperdal).html","C23H27FN4O2","free base","R-64766","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCCC5=N1",3.317,4,0,4]
["S1617","Sulfapyridine","e4","L3000-54","in 2mM DMSO","Bacterial","Microbiology","Sulfapyridine  is a sulfonamide antibacterial.",249.29,"144-83-2",{"v":2,"d":"2.00"},8.02,"<1","N/A","http://selleckchem.com/products/Sulfapyridine(Dagenan).html","C11H11N3O2S","free base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CC=C2",0.959,3,2,3]
["S1642","Methyldopa","f4","L3000-54","in 2mM DMSO","5-HT Receptor,Adrenergic Receptor,Decarboxylase,Dopamine Receptor","Metabolism","Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.",211.21,"555-30-6",{"v":2,"d":"2.00"},9.47,"<1","N/A","http://selleckchem.com/products/Methyldopa(Aldomet).html","C10H13NO4","free base","N/A","CC(N)(CC1=CC(=C(O)C=C1)O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S1698","Torsemide","g4","L3000-54","in 2mM DMSO","Chloride Channel","Transmembrane Transporters","Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.",348.42,"56211-40-6",{"v":3,"d":"3.00"},8.61,"<1","N/A","http://selleckchem.com/products/Torsemide(Demadex).html","C16H20N4O3S","free base","AC-4464, JDL-464","CC(C)NC(=O)N[S](=O)(=O)C1=C(NC2=CC(=CC=C2)C)C=CN=C1",{"v":0,"d":"0.000"},0,0,0]
["S1707","Eplerenone (CGP 30083)","h4","L3000-54","in 2mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Eplerenone (CGP 30083, SC-66110) is a mineralocorticoid receptor antagonist, and blocks the action of aldosterone, used to control high blood pressure.",414.49,"107724-20-9",{"v":4,"d":"4.00"},9.65,"<1","N/A","http://selleckchem.com/products/Eplerenone(Inspra).html","C24H30O6","free base","CGP 30083, SC-66110","COC(=O)C1CC2=CC(=O)CCC2(C)C34OC3CC5(C)C(CCC56CCC(=O)O6)C14",{"v":0,"d":"0.000"},0,0,0]
["S1724","Paliperidone","a5","L3000-54","in 2mM DMSO","Dopamine Receptor","Neuronal Signaling","Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.",426.48,"144598-75-4",{"v":4,"d":"4.00"},9.38,"<1","N/A","http://selleckchem.com/products/Paliperidone(Invega).html","C23H27FN4O3","free base","N/A","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCC(O)C5=N1",{"v":0,"d":"0.000"},0,0,0]
["S1837","Flubendazole","b5","L3000-54","in 2mM DMSO","Autophagy,Parasite","Autophagy","Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.",313.28,"31430-15-6",{"v":3,"d":"3.00"},9.58,"<1","N/A","http://selleckchem.com/products/flubendazole-flutelmium.html","C16H12FN3O3","free base","Flumoxanal, NSC 313680","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)C(=O)C3=CC=C(F)C=C3",{"v":3.26,"d":"3.260"},4,2,4]
["S1851","Oxibendazole","c5","L3000-54","in 2mM DMSO","Parasite","Microbiology","Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.",249.27,"20559-55-1",{"v":1,"d":"1.00"},4.01,"<1","N/A","http://selleckchem.com/products/oxibendazole.html","C12H15N3O3","Free Base","N/A","CCCOC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",2.506,4,2,5]
["S1977","Sarafloxacin HCl","d5","L3000-54","in 2mM DMSO","Antibiotics","Microbiology","Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.",421.83,"91296-87-6",{"v":4,"d":"4.00"},9.48,"<1","N/A","http://selleckchem.com/products/sarafloxacin-hydrochloride.html","C20H17F2N3O3.HCl","Hydrochloride","A-56620 HCl","Cl.OC(=O)C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(=C3)N4CCNCC4)C1=O",{"v":0,"d":"0.000"},0,0,0]
["S1986","Meclizine 2HCl","e5","L3000-54","in 2mM DMSO","CAR,Histamine Receptor","Neuronal Signaling","Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.",463.87,"1104-22-9",{"v":4,"d":"4.00"},8.62,"<1","N/A","http://selleckchem.com/products/meclizine-dihydrochloride.html","C25H27Cl2N2.2HCl","Dihydrochloride","NSC 28728,Meclozine dihydrochloride","Cl.Cl.CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(Cl)C=C4",{"v":0,"d":"0.000"},0,0,0]
["S2047","Lornoxicam","f5","L3000-54","in 2mM DMSO","COX","Neuronal Signaling","Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.",371.82,"70374-39-9",{"v":3,"d":"3.00"},8.07,"<1","N/A","http://selleckchem.com/products/lornoxicam-xefo.html","C13H10ClN3O4S2","free base","Chlortenoxicam","CN1C(=C(O)C2=C(C=C(Cl)S2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.913,4,2,2]
["S2110","Vinpocetine","g5","L3000-54","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","Vinpocetine (RGH-4405,Ethyl apovincaminate,AY 27255) is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia  and Alzheimer's disease.",350.45,"42971-09-5",{"v":3,"d":"3.00"},8.56,"<1","N/A","http://selleckchem.com/products/vinpocetine-cavinton.html","C22H26N2O2","free base","RGH-4405,Ethyl apovincaminate,AY 27255","CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)[N]1C5=CC=CC=C45",{"v":0,"d":"0.000"},0,0,0]
["S2150","Neratinib (HKI-272)","h5","L3000-54","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.",557.04,"698387-09-6",{"v":5,"d":"5.00"},8.98,"<1","N/A","http://selleckchem.com/products/Neratinib(HKI-272).html","C30H29ClN6O3","free base","N/A","CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(=C2NC3=CC=C(OCC4=NC=CC=C4)C(=C3)Cl)C#N",4.881,5,2,11]
["S2157","Taladegib (LY2940680)","a6","L3000-54","in 2mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Taladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. Phase 1/2.",{"v":512.5,"d":"512.50"},"1258861-20-9",{"v":5,"d":"5.00"},9.76,"<1","N/A","http://selleckchem.com/products/ly2940680.html","C26H24F4N6O","free base","N/A","C[N]1N=CC=C1C2=NN=C(N3CCC(CC3)N(C)C(=O)C4=C(C=C(F)C=C4)C(F)(F)F)C5=C2C=CC=C5",{"v":0,"d":"0.000"},0,0,0]
["S2206","Fostamatinib (R788) disodium","b6","L3000-54","in 2mM DMSO","Syk","Angiogenesis","Fostamatinib disodium  (R788, Tamatinib Fosdium), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.",624.42,"1025687-58-4",{"v":6,"d":"6.00"},9.61,"<1","N/A","http://selleckchem.com/products/R788(Fostamatinib-disodium).html","C23H24FN6O9P.2Na","Sodium Salt","Tamatinib Fosdium","[Na+].[Na+].COC1=C(OC)C(=CC(=C1)NC2=NC=C(F)C(=N2)NC3=CC=C4OC(C)(C)C(=O)N(CO[P]([O-])([O-])=O)C4=N3)OC",{"v":0,"d":"0.000"},0,0,0]
["S2251","(-)-Huperzine A (HupA)","c6","L3000-54","in 2mM DMSO","AChR,GluR","Neuronal Signaling","(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.",242.32,"102518-79-6",0.66,2.72,"<1","N/A","http://selleckchem.com/products/(-)-Huperzine-A.html","C15H18N2O","Free Base","N/A","C\\C=C/1C2CC3=C(C=CC(=O)N3)C1(N)CC(=C2)C",1.056,1,2,0]
["S2292","Diosmin","d6","L3000-54","in 2mM DMSO","AhR","Metabolism","Diosmin is an agonist of the aryl hydrocarbon receptor (AhR). Diosmin is a semisynthetic phlebotropic agent and a flavonoid found in a variety of citrus fruits.",608.55,"520-27-4",{"v":6,"d":"6.00"},9.86,"<1","N/A","http://selleckchem.com/products/Diosmin.html","C28H32O15","Free Base","N/A","COC1=C(O)C=C(C=C1)C2=CC(=O)C3=C(O2)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O",-0.395,7,8,7]
["S2395","Rheochrysidin","e6","L3000-54","in 2mM DMSO","Anti-infection","Microbiology","Rheochrysidin (Physcione) is an anthraquinone from roots of Rheum officinale Baill.",284.26,"521-61-9",{"v":1,"d":"1.00"},3.52,"<1","N/A","http://selleckchem.com/products/Rheochrysidin-Physcione.html","C16H12O5","Free Base","Physcione","COC1=CC2=C(C(=C1)O)C(=O)C3=C(O)C=C(C)C=C3C2=O",2.794,3,2,1]
["S2476","Itraconazole (R 51211)","f6","L3000-54","in 2mM DMSO","Autophagy,Fungal,Hedgehog/Smoothened,P450 (e.g. CYP17)","Stem Cells & Wnt","Itraconazole (R 51211) is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.",705.65,"84625-61-6",{"v":7,"d":"7.00"},9.92,"<1","N/A","http://selleckchem.com/products/Itraconazole(Sporanox).html","C35H38Cl2N8O4","free base","R 51211","CCC(C)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C[N]6C=NC=N6)(O5)C7=CC=C(Cl)C=C7Cl)C=C4",6.434,7,0,11]
["S2530","7-Aminocephalosporanic acid","g6","L3000-54","in 2mM DMSO","Antibiotics","Microbiology","7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates.",272.28,"957-68-6",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/7-Aminocephalosporanic-acid.html","C10H12N2O5S","Free Base","N/A","CC(=O)OCC1=C(N2C(SC1)C(N)C2=O)C(O)=O",-3.745,4,1,4]
["S2582","Trazodone HCl","h6","L3000-54","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Trazodone HCl (AF-1161, KB-831) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.",408.32,"25332-39-2",{"v":4,"d":"4.00"},{"v":9.8,"d":"9.80"},"<1","N/A","http://selleckchem.com/products/trazodone-hydrochloride-desyrel.html","C19H22ClN5O.HCl","Hydrochloride","AF-1161, KB-831","Cl.ClC1=CC(=CC=C1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2",{"v":0,"d":"0.000"},0,0,0]
["S2597","Oseltamivir Phosphate","a7","L3000-54","in 2mM DMSO","Influenza Virus,Neuraminidase","Microbiology","Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.",{"v":410.4,"d":"410.40"},"204255-11-8",{"v":4,"d":"4.00"},9.75,"<1","N/A","http://selleckchem.com/products/oseltamivir-phosphate-Tamiflu.html","C16H28N2O4.H3PO4","Phosphate salt","Tamiflu","CCOC(=O)C1=CC(OC(CC)CC)C(NC(C)=O)C(N)C1.O[P](O)(O)=O",0.577,4,2,8]
["S2628","Gedatolisib (PKI-587)","b7","L3000-54","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.",615.73,"1197160-78-3",{"v":2,"d":"2.00"},3.25,"<1","N/A","http://selleckchem.com/products/pki587.html","C32H41N9O4","Free Base","PF-05212384","CN(C)C1CCN(CC1)C(=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C=C2",2.525,7,2,7]
["S2638","NU7441 (KU-57788)","c7","L3000-54","in 2mM DMSO","CRISPR/Cas9,DNA-PK,mTOR,PI3K","DNA Damage/DNA Repair","NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.",413.49,"503468-95-9",{"v":4,"d":"4.00"},9.67,"<1","N/A","http://selleckchem.com/products/nu7441.html","C25H19NO3S","free base","N/A","O=C1C=C(OC2=C1C=CC=C2C3=CC=CC4=C3SC5=C4C=CC=C5)N6CCOCC6",5.403,3,0,2]
["S2684","Pidnarulex (CX-5461)","d7","L3000-54","in 2mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.",513.61,"1138549-36-6",{"v":2,"d":"2.00"},3.89,"<1","N/A","http://www.selleck.cn/products/cx-5461.html","C27H27N7O2S","Free Base","N/A","CN1CCCN(CC1)C2=CC=C3C(=O)C(=C4SC5=C(C=CC=C5)N4C3=N2)C(=O)NCC6=CN=C(C)C=N6",3.188,5,1,4]
["S2704","LY2109761","e7","L3000-54","in 2mM DMSO","Apoptosis related,Autophagy,TGF-beta/Smad","TGF-beta/Smad","LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.",441.52,"700874-71-1",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/ly2109761.html","C26H27N5O2","Free Base","N/A","C1C[N]2N=C(C3=NC=CC=C3)C(=C2C1)C4=CC=NC5=C4C=CC(=C5)OCCN6CCOCC6",{"v":3.62,"d":"3.620"},5,0,6]
["S2735","MK-8776 (SCH 900776)","f7","L3000-54","in 2mM DMSO","CDK,Chk","Cell Cycle","MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.",376.25,"891494-63-6",{"v":3,"d":"3.00"},7.97,"<1","N/A","http://selleckchem.com/products/sch-900776.html","C15H18BrN7","Free Base","N/A","C[N]1C=C(C=N1)C2=C3N=C(C4CCCNC4)C(=C(N)[N]3N=C2)Br",{"v":1.32,"d":"1.320"},3,2,2]
["S2744","CCT137690","g7","L3000-54","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.",551.48,"1095382-05-0",{"v":4,"d":"4.00"},7.25,"<1","N/A","http://selleckchem.com/products/cct137690.html","C26H31BrN8O","Free Base","N/A","CN1CCN(CC1)C2=CC=C(C=C2)C3=NC4=C(N5CCN(CC5)CC6=NOC(=C6)C)C(=CN=C4[NH]3)Br",3.704,4,1,5]
["S2788","Capmatinib (INCB28060)","h7","L3000-54","in 2mM DMSO","Apoptosis related,c-Met,Wnt/beta-catenin","Protein Tyrosine Kinase","Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.",412.42,"1029712-80-8",{"v":2,"d":"2.00"},4.85,"<1","N/A","http://selleckchem.com/products/incb28060.html","C23H17FN6O","Free Base","INC280, NVP-INC280","CNC(=O)C1=CC=C(C=C1F)C2=N[N]3C(=CN=C3N=C2)CC4=CC=C5N=CC=CC5=C4",3.246,5,1,4]
["S2805","LY364947","a8","L3000-54","in 2mM DMSO","Casein Kinase,Mixed Lineage Kinase,RIP kinase,TGF-beta/Smad","TGF-beta/Smad","LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.",{"v":272.3,"d":"272.30"},"396129-53-6",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/ly364947.html","C17H12N4","Free Base","HTS 466284","[NH]1C=C(C2=C3C=CC=CC3=NC=C2)C(=N1)C4=NC=CC=C4",3.203,3,1,2]
["S2827","Torin 1","b8","L3000-54","in 2mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.",607.62,"1222998-36-8",{"v":2,"d":"2.00"},3.29,"<1","N/A","http://selleckchem.com/products/torin-1.html","C35H28F3N5O2","Free Base","N/A","CCC(=O)N1CCN(CC1)C2=CC=C(C=C2C(F)(F)F)N3C(=O)C=CC4=C3C5=CC(=CC=C5N=C4)C6=CC7=CC=CC=C7N=C6",5.914,4,0,5]
["S2870","TG100713","c8","L3000-54","in 2mM DMSO","PI3K","PI3K/Akt/mTOR","TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.",254.25,"925705-73-3",{"v":2,"d":"2.00"},7.87,"<1","N/A","http://selleckchem.com/products/tg-100713.html","C12H10N6","Free Base","N/A","NC1=NC(=C2N=C(C=NC2=N1)C3=CC(=CC=C3)O)N",0.982,4,3,1]
["S2893","NU7026","d8","L3000-54","in 2mM DMSO","Apoptosis related,DNA-PK,PI3K","DNA Damage/DNA Repair","NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.",281.31,"154447-35-5",{"v":1,"d":"1.00"},3.55,"<1","N/A","http://selleckchem.com/products/nu7026.html","C17H15NO3","Free Base","LY293646","O=C1C=C(OC2=C1C=CC3=C2C=CC=C3)N4CCOCC4",2.732,3,0,1]
["S2920","Mozavaptan","e8","L3000-54","in 2mM DMSO","Vasopressin Receptor","GPCR & G Protein","Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.",427.54,"137975-06-5",{"v":1,"d":"1.00"},2.34,"<1","N/A","http://selleckchem.com/products/mozavaptan.html","C27H29N3O2","Free Base","OPC-31260","CN(C)C1CCCN(C(=O)C2=CC=C(NC(=O)C3=C(C)C=CC=C3)C=C2)C4=C1C=CC=C4",4.654,2,1,4]
["S3042","Purmorphamine","f8","L3000-54","in 2mM DMSO","Autophagy,Hedgehog/Smoothened","Stem Cells & Wnt","Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.",520.62,"483367-10-8",{"v":4,"d":"4.00"},7.68,"<1","N/A","http://selleckchem.com/products/purmorphamine.html","C31H32N6O2","Free Base","Shh Signaling Antagonist VI","C1CCC(CC1)[N]2C=NC3=C2N=C(OC4=C5C=CC=CC5=CC=C4)N=C3NC6=CC=C(C=C6)N7CCOCC7",6.758,5,1,6]
["S3059","Enrofloxacin","g8","L3000-54","in 2mM DMSO","Antibiotics","Microbiology","Enrofloxacin (BAY-Vp2674, PD160788) is a fluoroquinolone antibiotic.",359.39,"93106-60-6",{"v":3,"d":"3.00"},8.35,"<1","N/A","http://selleckchem.com/products/enrofloxacin.html","C19H22FN3O3","free base","BAY-Vp2674, PD160788","CCN1CCN(CC1)C2=CC3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3614","Lupeol","h8","L3000-54","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.",426.72,"545-47-1",{"v":1,"d":"1.00"},2.34,"<1","N/A","http://selleckchem.com/products/lupeol.html","C30H50O","free base","(3β,13ξ)-Lup-20(29)-en-3-ol, Clerodol, Monogynol B, Fagarasterol, Farganasterol","CC(=C)C1CCC2(C)CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12",7.403,0,1,1]
["S3770","Sodium Aescinate","a9","L3000-54","in 2mM DMSO","NF-κB","NF-κB","Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.  Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.",1123.21,"20977-05-3",{"v":10,"d":"10.00"},{"v":8.9,"d":"8.90"},"N/A","N/A","http://selleckchem.com/products/sodium-aescinate.html","C54H83NaO23","sodium salt","Escin sodium salt","CC(OC(C)=O)C(C)C(=O)OCC12C(O)C3OC1CC4(C)C(=CCC5C6(C)CCC(OC7OC(C(OC8OC(CO)C(O)C(O)C8O)C(O)C7OC9OCC(O)C(O)C9O)C(=O)O[Na])C(C)(CO)C6CCC45C)C2CC3(C)C",-0.485,13,10,17]
["S3801","Sodium Houttuyfonate","b9","L3000-54","in 2mM DMSO","Anti-infection","Microbiology","Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.",330.42,"1847-58-1",{"v":2,"d":"2.00"},6.05,"<1","N/A","http://selleckchem.com/products/sodium-houttuyfonate.html","C14H27O5S.Na","sodium salt","N/A","[Na+].CCCCCCCCCCCCOC(=O)C[S]([O-])(=O)=O",2.026,2,0,14]
["S3821","Nuciferine","c9","L3000-54","in 2mM DMSO","5-HT Receptor,5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.",295.38,"475-83-2",{"v":2,"d":"2.00"},6.77,"<1","N/A","http://selleckchem.com/products/nuciferine.html","C19H21NO2","free base","Sanjoinine E, (-)-Nuciferine, VLT 049","COC1=C(OC)C2=C3C(CC4=C2C=CC=C4)N(C)CCC3=C1",3.567,2,0,2]
["S3891","Vincamine","d9","L3000-54","in 2mM DMSO","Others","Others","Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.",354.44,"1617-90-9",{"v":3,"d":"3.00"},8.46,"N/A","N/A","http://selleckchem.com/products/vincamine.html","C21H26N2O3","free base","Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan","CCC12CCCN3CCC4=C(C13)[N](C5=CC=CC=C45)C(O)(C2)C(=O)OC",3.546,2,0,3]
["S4033","Sennoside A","e9","L3000-54","in 2mM DMSO","MAO","Metabolism","Sennoside A (NSC 112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.",862.74,"81-27-6","N/A",{"v":2,"d":"2.00"},"<1","N/A","http://selleckchem.com/products/sennoside-a.html","C42H38O20","Free Base","NSC 112929","OCC1OC(OC2=CC=CC3=C2C(=O)C4=C(O)C=C(C=C4C3C5C6=C(C(=O)C7=C(O)C=C(C=C57)C(O)=O)C(=CC=C6)OC8OC(CO)C(O)C(O)C8O)C(O)=O)C(O)C(O)C1O",0.409,8,10,9]
["S4126","Retinyl (Vitamin A) Palmitate","f9","L3000-54","in 2mM DMSO","Vitamin","Metabolism","Retinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid.",524.86,"79-81-2",{"v":3,"d":"3.00"},5.72,"<1","N/A","http://selleckchem.com/products/vitamin-a-palmitate.html","C36H60O2","Free Base","Vitamin A palmitate","CCCCCCCCCCCCCCCC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C",12.293,2,0,21]
["S4262","Ebastine","g9","L3000-54","in 2mM DMSO","Histamine Receptor","Neuronal Signaling","Ebastine(LAS-W 090,RP64305) is a potent H1-histamine receptor antagonist, used for allergic disorders.",469.66,"90729-43-4",{"v":4,"d":"4.00"},8.52,"<1","N/A","http://selleckchem.com/products/ebastine.html","C32H39NO2","free base","LAS-W 090,RP64305","CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4",6.582,2,0,10]
["S4605","Folic acid","h9","L3000-54","in 2mM DMSO","Vitamin","Metabolism","Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.",{"v":441.4,"d":"441.40"},"59-30-3",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/folic-acid.html","C19H19N7O6","free base","Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate","NC1=NC(=O)C2=C(N1)N=CC(=N2)CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",-0.232,7,4,9]
["S4642","Dolutegravir Sodium","a10","L3000-54","in 2mM DMSO","Integrase","Microbiology","Dolutegravir Sodium (GSK-1349572A) is a HIV integrase inhibitor with IC50 of 2.7 nM.",441.36,"1051375-19-9",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://www.selleck.cn/products/dolutegravir-sodium.html","C20H19F2N3O5.Na","Sodium","GSK-1349572A","CC1CCOC2CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(=C3C(=O)N12)O[Na]",0.391,5,1,4]
["S5018","Mebhydrolin napadisylate","b10","L3000-54","in 2mM DMSO","ADC Cytotoxin,Histamine Receptor","Neuronal Signaling","Mebhydrolin Napadisylate (Diazoline, Diazolin, Incidal, Omeril) is classified as an antihistamine drug classes used to treat allergies.",841.05,"6153-33-9",{"v":8,"d":"8.00"},9.51,"N/A","N/A","http://selleckchem.com/products/mebhydrolin-napadisylate.html","C48H48N4O6S2","salt","Diazoline, Diazolin, Incidal, Omeril","CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=CC=C4.CN5CCC6=C(C5)C7=C(C=CC=C7)[N]6CC8=CC=CC=C8.O[S](=O)(=O)C9=C%10C=CC=C(C%10=CC=C9)[S](O)(=O)=O",9.536,0,0,6]
["S5232","Alectinib (CH5424802) hydrochloride","c10","L3000-54","in 2mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.",519.08,"1256589-74-8",{"v":2,"d":"2.00"},3.85,"<1","N/A","http://selleckchem.com/products/alectinib-hydrochloride.html","C30H34N4O2.HCl","hydrochloride","AF802, RO5424802, RG-7853","Cl.CCC1=C(C=C2C(=C1)C(=O)C3=C([NH]C4=C3C=CC(=C4)C#N)C2(C)C)N5CCC(CC5)N6CCOCC6",5.585,2,1,3]
["S5249","Coptisine chloride","d10","L3000-54","in 2mM DMSO","IDO/TDO","Metabolism","Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM.",355.77,"6020-18-4",{"v":3,"d":"3.00"},8.43,"<1","N/A","http://selleckchem.com/products/coptisine-chloride.html","C19H14NO4.Cl","chloride","Q-100696, NSC-119754","[Cl-].C1OC2=CC3=C(C=C2O1)C4=CC5=C(C=[N+]4CC3)C6=C(OCO6)C=C5",1.089,4,0,0]
["S5272","Toceranib phosphate","e10","L3000-54","in 2mM DMSO","PDGFR,VEGFR","Protein Tyrosine Kinase","Toceranib phosphate (Palladia, SU11654), the phosphate salt of toceranib, is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR, and Kit with Ki values of 6 nM and 5 nM for Flk-1/KDR and PDGFRβ, respectively.",494.45,"874819-74-6",{"v":2,"d":"2.00"},4.04,{"v":2,"d":"2.00"},4.04,"https://www.selleckchem.com/products/toceranib-phosphate.html","C22H25FN4O2.H3O4P","phosphate","Palladia, SU11654","CC1=C(C(=C([NH]1)\\C=C2/C(=O)NC3=C2C=C(F)C=C3)C)C(=O)NCCN4CCCC4.O[P](O)(O)=O",2.292,2,3,5]
["S5516","Ellagic Acid hydrate","f10","L3000-54","in 2mM DMSO","Casein Kinase","Metabolism","Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.",320.21,"314041-08-2",{"v":2,"d":"2.00"},6.25,"N/A","N/A","http://selleckchem.com/products/ellagic-acid-hydrate.html","C14H6O8.H2O","monohydrate","N/A","O.OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",1.377,4,4,0]
["S5577","6-Biopterin","g10","L3000-54","in 2mM DMSO","NOS","Immunology & Inflammation","6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.",237.22,"22150-76-1",{"v":1,"d":"1.00"},4.22,"<1","N/A","https://www.selleckchem.com/products/6-biopterin.html","C9H11N5O3","free base","L-Biopterin, L-Erythro-Biopterin","CC(O)C(O)C1=NC2=C(NC(=NC2=O)N)N=C1",-1.131,4,4,2]
["S5677","Xanthopterin Hydrate","h10","L3000-54","in 2mM DMSO","Others","Others","Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species.",197.15,"5979-01-1",{"v":1,"d":"1.00"},5.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/xanthopterin-hydrate.html","C6H7N5O3","Hydrate","N/A","O.NC1=NC(=C2N=C(O)C=NC2=N1)O",-0.128,4,3,0]
["S6642","Branaplam (LMI070)","a11","L3000-54","in 2mM DMSO","SMN","DNA Damage/DNA Repair","Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM.",393.48,"1562338-42-4",{"v":3,"d":"3.00"},7.62,"<1","N/A","http://www.selleck.cn/products/branaplam-lmi070.html","C22H27N5O2","Free Base","N/A","CC1(C)CC(CC(C)(C)N1)OC2=NN=C(C=C2)C3=C(O)C=C(C=C3)C4=C[NH]N=C4",3.141,4,3,4]
["S7004","EPZ005687","b11","L3000-54","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.",539.67,"1396772-26-1",{"v":2,"d":"2.00"},3.71,"<1","N/A","http://selleckchem.com/products/epz005687.html","C32H37N5O3","Free Base","N/A","CC1=CC(=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C4CCCC4)C5=CC=C(CN6CCOCC6)C=C5)C(=O)N1)C",3.919,4,2,7]
["S7035","XL388","c11","L3000-54","in 2mM DMSO","mTOR","PI3K/Akt/mTOR","XL388 is a highly potent, selective, ATP-competitive inhibitor of  mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.",{"v":455.5,"d":"455.50"},"1251156-08-7",1.25,2.74,"<1","N/A","http://selleckchem.com/products/xl388.html","C23H22FN3O4S","free base","N/A","CC1=C(F)C(=CC=C1C(=O)N2CCOC3=CC=C(C=C3C2)C4=CN=C(N)C=C4)[S](C)(=O)=O",3.007,5,1,3]
["S7061","GSK126","d11","L3000-54","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases.",526.67,"1346574-57-9",{"v":3,"d":"3.00"},{"v":5.7,"d":"5.70"},"<1","N/A","http://selleckchem.com/products/gsk126.html","C31H38N6O2","Free Base","GSK2816126A, GSK2816126","CCC(C)[N]1C=C(C)C2=C(C=C(C=C12)C3=CC=C(N=C3)N4CCNCC4)C(=O)NCC5=C(C)C=C(C)NC5=O",4.114,3,3,7]
["S7085","IWP-2","e11","L3000-54","in 2mM DMSO","Casein Kinase,Wnt/beta-catenin","Stem Cells & Wnt","IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.",{"v":466.6,"d":"466.60"},"686770-61-6",{"v":4,"d":"4.00"},8.57,"<1","N/A","http://selleckchem.com/products/iwp-2.html","C22H18N4O2S3","Free Base","N/A","CC1=CC2=C(C=C1)N=C(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3C5=CC=CC=C5)S2",4.277,4,1,5]
["S7105","BAM7","f11","L3000-54","in 2mM DMSO","Bcl-2","Apoptosis","BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.",405.47,"331244-89-4",{"v":2,"d":"2.00"},4.93,"<1","N/A","http://selleckchem.com/products/bam7.html","C21H19N5O2S","Free Base","N/A","CCOC1=CC=CC=C1N\\N=C2/C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C",{"v":4.1,"d":"4.100"},5,1,6]
["S7128","Tazemetostat (EPZ-6438)","g11","L3000-54","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.",572.74,"1403254-99-8",{"v":5,"d":"5.00"},8.73,"<1","N/A","http://selleckchem.com/products/epz-6438.html","C34H44N4O4","free base","E7438","CCN(C1CCOCC1)C2=C(C)C(=CC(=C2)C3=CC=C(CN4CCOCC4)C=C3)C(=O)NCC5=C(C)C=C(C)NC5=O",3.506,4,2,9]
["S7164","GSK343","h11","L3000-54","in 2mM DMSO","Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. GSK343 induces autophagy.",541.69,"1346704-33-3",{"v":2,"d":"2.00"},3.69,"<1","N/A","http://www.selleck.cn/products/gsk343.html","C31H39N7O2","Free Base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC(=NC=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.902,4,2,8]
["S7221","Vesatolimod (GS-9620)","a2","L3000-55","in 2mM DMSO","TLR","Immunology & Inflammation","Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7.",410.51,"1228585-88-3",{"v":1,"d":"1.00"},2.44,"<1","N/A","http://selleckchem.com/products/gs-9620.html","C22H30N6O2","Free Base","N/A","CCCCOC1=NC(=C2NC(=O)CN(CC3=CC=CC(=C3)CN4CCCC4)C2=N1)N",3.302,4,2,8]
["S7342","UNC2250","b2","L3000-55","in 2mM DMSO","Mertk","Protein Tyrosine Kinase","UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.",440.58,"1493694-70-4",{"v":2,"d":"2.00"},4.54,"<1","N/A","http://selleckchem.com/products/unc2250.html","C24H36N6O2","Free Base","N/A","CCCCNC1=NC(=C(C=N1)C2=CC=C(CN3CCOCC3)C=N2)NC4CCC(O)CC4",3.236,4,3,9]
["S7400","ISRIB (trans-isomer)","c2","L3000-55","in 2mM DMSO","PERK","Apoptosis","ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.",451.34,"1597403-47-8",{"v":4,"d":"4.00"},8.86,"<1","N/A","http://selleckchem.com/products/isrib-trans-isomer.html","C22H24Cl2N2O4","Free Base","N/A","ClC1=CC=C(OCC(=O)NC2CCC(CC2)NC(=O)COC3=CC=C(Cl)C=C3)C=C1",4.055,4,2,8]
["S7485","CCT007093","d2","L3000-55","in 2mM DMSO","phosphatase","Others","CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.",272.39,"176957-55-4",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/cct007093.html","C15H12OS2","Free Base","N/A","O=C1C(/CC\\C1=C/C2=CC=CS2)=C/C3=CC=CS3",4.588,1,0,2]
["S7518","Voreloxin (SNS-595) hydrochloride","e2","L3000-55","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.",{"v":437.9,"d":"437.90"},"175519-16-1",{"v":1,"d":"1.00"},2.28,{"v":1,"d":"1.00"},2.28,"http://selleckchem.com/products/voreloxin-sns-595.html","C18H20ClN5O4S","hydrochloride","Vosaroxin","Cl.CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(O)=O",-1.138,5,1,5]
["S7698","LY2584702","f2","L3000-55","in 2mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.",445.42,"1082949-67-4",{"v":1,"d":"1.00"},2.25,"<1","N/A","http://selleckchem.com/products/ly2584702.html","C21H19F4N7","Free Base","N/A","C[N]1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=N[NH]4)C5=CC=C(F)C(=C5)C(F)(F)F",{"v":4.18,"d":"4.180"},4,1,4]
["S7756","Indoximod (NLG-8189）","g2","L3000-55","in 2mM DMSO","IDO/TDO","Metabolism","Indoximod (NLG-8189, 1-Methyl-D-tryptophan, 1-MT), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!",218.25,"110117-83-4",{"v":1,"d":"1.00"},4.58,"<1","N/A","http://selleckchem.com/products/indoximod-nlg-8189.html","C12H14N2O2","Free Base","1-Methyl-D-tryptophan, 1-MT","C[N]1C=C(CC(N)C(O)=O)C2=CC=CC=C12",-1.106,1,1,3]
["S7790","A-1210477","h2","L3000-55","in 2mM DMSO","Bcl-2","Apoptosis","A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.",850.04,"1668553-26-1",{"v":3,"d":"3.00"},3.53,"<1","N/A","http://selleckchem.com/products/a-1210477.html","C46H55N7O7S","Free Base","N/A","CN(C)[S](=O)(=O)N1CCN(CC1)C2=CC=C(OCC3=C(C(=N[N]3C)C)C4=C5[N](CCN6CCOCC6)C(=C(CCCOC7=C8C=CC=CC8=CC=C7)C5=CC=C4)C(O)=O)C=C2",3.151,7,0,16]
["S7819","BLU9931","a3","L3000-55","in 2mM DMSO","FGFR","Angiogenesis","BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.",509.38,"1538604-68-0",{"v":4,"d":"4.00"},7.85,"<1","N/A","http://selleckchem.com/products/blu9931.html","C26H22Cl2N4O3","Free Base","N/A","COC1=CC(=C(Cl)C(=C1Cl)C2=CC3=CN=C(NC4=C(NC(=O)C=C)C=CC=C4C)N=C3C=C2)OC",6.577,5,2,7]
["S7840","Dorsomorphin (Compound C)","b3","L3000-55","in 2mM DMSO","AMPK,Autophagy,TGF-beta/Smad","PI3K/Akt/mTOR","Dorsomorphin (Compound C, BML-275) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble <a target='_blank' href='https://www.selleckchem.com/products/dorsomorphin-2hcl.html'>S7306 Dorsomorphin (Compound C) 2HCl</a> is recommended.",399.49,"866405-64-3",{"v":1,"d":"1.00"},{"v":2.5,"d":"2.50"},"<1","N/A","http://selleckchem.com/products/dorsomorphin.html","C24H25N5O","Free Base","BML-275,Compound C","C1CCN(CC1)CCOC2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC=C5",3.028,4,0,6]
["S7842","LY3009120","c3","L3000-55","in 2mM DMSO","Autophagy,Raf","MAPK","LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. LY03009120 induces autophagy. Phase 1.",424.51,"1454682-72-4",{"v":3,"d":"3.00"},7.07,"<1","N/A","http://selleckchem.com/products/ly3009120.html","C23H29FN6O","Free Base","DP-4978","CNC1=NC=C2C=C(C(=NC2=N1)C)C3=CC(=C(F)C=C3C)NC(=O)NCCC(C)(C)C",4.158,4,3,6]
["S7846","Dubermatinib(TP-0903)","d3","L3000-55","in 2mM DMSO","Apoptosis related,Axl","Protein Tyrosine Kinase","TP-0903 is a potent and selective AXL Inhibitor with IC50 of 27 nM. TP-0903 is highly effective in inducing apoptosis.",516.06,"1341200-45-0",{"v":3,"d":"3.00"},5.81,"<1","N/A","http://selleckchem.com/products/tp-0903.html","C24H30ClN7O2S","Free Base","N/A","CN1CCN(CC1)CC2=CC=C(NC3=NC=C(Cl)C(=N3)NC4=CC=CC=C4[S](=O)(=O)N(C)C)C=C2",4.023,4,2,8]
["S8113","BI-9564","e3","L3000-55","in 2mM DMSO","Epigenetic Reader Domain","Epigenetics","BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains with the IC50 of 75 nM and 3.4 µM, respectively.",353.41,"1883429-22-8",{"v":3,"d":"3.00"},8.49,"<1","N/A","http://selleckchem.com/products/bi-9564.html","C20H23N3O3","Free Base","N/A","COC1=C(CN(C)C)C=C(OC)C(=C1)C2=CN(C)C(=O)C3=C2C=CN=C3",1.301,4,0,5]
["S8229","Brigatinib (AP26113)","f3","L3000-55","in 2mM DMSO","ALK,EGFR,FLT3,IGF-1R,ROS1","Angiogenesis","Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.",584.09,"1197953-54-0",{"v":3,"d":"3.00"},5.14,"<1","N/A","http://www.selleck.cn/products/brigatinib-ap26113.html","C29H39ClN7O2P","Free Base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)NC3=CC=CC=C3[P](C)(C)=O)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.084,6,2,8]
["S8527","ROC-325","g3","L3000-55","in 2mM DMSO","Autophagy","Autophagy","ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.",503.06,"1859141-26-6",{"v":4,"d":"4.00"},7.95,"<1","N/A","http://selleckchem.com/products/roc-325.html","C28H27ClN4OS","free base","N/A","CN(CCNC1=CC=NC2=C1C=CC(=C2)Cl)CCNC3=CC=C(C)C4=C3C(=O)C5=CC=CC=C5S4",6.264,2,2,8]
["S8548","Roblitinib (FGF401)","h3","L3000-55","in 2mM DMSO","FGFR","Protein Tyrosine Kinase","Roblitinib (FGF401) is an FGFR4-selective inhibitor with an IC50 of 1.9 nM. It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.",506.56,"1708971-55-4",{"v":5,"d":"5.00"},9.87,"<1","N/A","http://selleckchem.com/products/fgf401.html","C25H30N8O4","free base","N/A","COCCNC1=C(C=NC(=C1)NC(=O)N2CCCC3=C2N=C(C=O)C(=C3)CN4CCN(C)CC4=O)C#N",0.939,6,2,8]
["S8568","G1T38","a4","L3000-55","in 2mM DMSO","CDK","Cell Cycle","G1T38 (Lerociclib) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively.",{"v":474.6,"d":"474.60"},"1628256-23-4",{"v":2,"d":"2.00"},4.21,"<1","N/A","http://www.selleck.cn/products/g1t38.html","C26H34N8O","free base","Lerociclib","CC(C)N1CCN(CC1)C2=CN=C(NC3=NC4=C(C=N3)C=C5[N]4C6(CCCCC6)CNC5=O)C=C2",4.087,4,2,4]
["S8724","Lazertinib","b4","L3000-55","in 2mM DMSO","EGFR","Protein Tyrosine Kinase","Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.",554.64,"1903008-80-9",{"v":4,"d":"4.00"},7.21,"<1","N/A","http://selleckchem.com/products/lazertinib-yh25448-gns-1480.html","C30H34N8O3","free base","YH25448,GNS-1480","COC1=CC(=C(NC(=O)C=C)C=C1NC2=NC=CC(=N2)[N]3C=C(CN(C)C)C(=N3)C4=CC=CC=C4)N5CCOCC5",{"v":4.56,"d":"4.560"},6,2,10]
["S9067","Pseudoprotodioscin","c4","L3000-55","in 2mM DMSO","Immunology & Inflammation related,MicroRNA,SREBP","Immunology & Inflammation","Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.",1031.18,"102115-79-7",{"v":10,"d":"10.00"},{"v":9.7,"d":"9.70"},"N/A","N/A","https://www.selleckchem.com/products/pseudoprotodioscin.html","C51H82O21","free base","OP31761","CC(CCC1=C(C)C2C(CC3C4CC=C5CC(CCC5(C)C4CCC23C)OC6OC(CO)C(OC7OC(C)C(O)C(O)C7O)C(O)C6OC8OC(C)C(O)C(O)C8O)O1)COC9OC(CO)C(O)C(O)C9O",-0.502,9,12,14]
["S9081","Anemoside B4","d4","L3000-55","in 2mM DMSO","Others","Others","Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10.",1221.38,"129741-57-7",{"v":10,"d":"10.00"},8.19,"N/A","N/A","https://www.selleckchem.com/products/anemoside-b4.html","C59H96O26","Salt","Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4","CC1OC(OC2C(O)C(O)C(OCC3OC(OC(=O)C45CCC(C4C6CCC7C8(C)CCC(OC9OCC(O)C(O)C9OC%10OC(C)C(O)C(O)C%10O)C(C)(CO)C8CCC7(C)C6(C)CC5)C(C)=C)C(O)C(O)C3O)OC2CO)C(O)C(O)C1O",-1.175,11,15,15]
["S9246","Tiliroside","e4","L3000-55","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.",594.52,"20316-62-5",{"v":3,"d":"3.00"},5.05,"N/A","N/A","https://www.selleckchem.com/products/tiliroside.html","C30H26O13","free base","N/A","OC1C(O)C(COC(=O)\\C=C\\C2=CC=C(O)C=C2)OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC=C(O)C=C5)C1O",2.212,6,7,8]
["S9257","Acetylshikonin","f4","L3000-55","in 2mM DMSO","P450 (e.g. CYP17)","Metabolism","Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.",330.33,"24502-78-1",{"v":2,"d":"2.00"},6.05,"N/A","N/A","https://www.selleckchem.com/products/acetylshikonin.html","C18H18O6","free base","N/A","CC(C)=CCC(OC(C)=O)C1=CC(=O)C2=C(C(=CC=C2O)O)C1=O",2.824,4,2,5]
["S5098","Gefitinib hydrochloride","g4","L3000-55","in 2mM DMSO","EGFR","Protein Tyrosine Kinase","Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.",483.36,"184475-55-6","N/A",{"v":2,"d":"2.00"},{"v":1,"d":"1.00"},2.07,"http://selleckchem.com/products/gefitinib-hydrochloride.html","C22H24ClFN4O3.HCl","hydrochloride","ZD1839 hydrochloride","Cl.COC1=CC2=C(C=C1OCCCN3CCOCC3)C(=NC=N2)NC4=CC(=C(F)C=C4)Cl",4.585,5,1,8]
["S1502","Cephalexin","h4","L3000-55","in 2mM DMSO","Antibiotics,Bacterial","Microbiology","Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.",347.39,"15686-71-2","N/A",{"v":2,"d":"2.00"},"N/A","N/A","http://selleckchem.com/products/Cephalexin-(Cefalexin).html","C16H17N3O4S","free base","Cefalexin","CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CC=CC=C3)C2=O)C(O)=O",-2.255,3,2,4]
["S3299","Demethyleneberberine","a5","L3000-55","in 2mM DMSO","AMPK,Interleukins,NF-κB,Peroxidases,TNF-alpha","Immunology & Inflammation","Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.",324.35,"25459-91-0",{"v":3,"d":"3.00"},9.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/demethyleneberberine.html","C19H18NO4","free base","DMB","COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(O)C=C4CC3)O",{"v":3.71,"d":"3.710"},2,2,2]
["S3304","Stylopine","b5","L3000-55","in 2mM DMSO","COX,Interleukins,NOS,PGES,TNF-alpha","Immunology & Inflammation","Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.",323.34,"4312-32-7",{"v":2.5,"d":"2.50"},7.73,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/stylopine-trahydocoptisine-.html","C19H17NO4","free base","(R,S)-Stylopine, Tetrahydrocoptisine","C1OC2=CC3=C(C=C2O1)C4CC5=CC=C6OCOC6=C5CN4CC3",3.201,4,0,0]
["S6949","OTX008","c5","L3000-55","in 2mM DMSO","Galectin","Immunology & Inflammation","OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with anti-tumoural activity.",937.18,"286936-40-1",{"v":3,"d":"3.00"},{"v":3.2,"d":"3.20"},"<1","N/A","https://www.selleckchem.com/products/otx008.html","C52H72N8O8","Free Base","Calixarene 0118, PTX-008","CN(C)CCNC(=O)COC1=C2CC3=CC=CC(=C3OCC(=O)NCCN(C)C)CC4=CC=CC(=C4OCC(=O)NCCN(C)C)CC5=CC=CC(=C5OCC(=O)NCCN(C)C)CC1=CC=C2",4.626,8,4,24]
["E0124","Chelerythrine","d5","L3000-55","in 2mM DMSO","Bcl-2,PKC","TGF-beta/Smad","Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.",348.37,"34316-15-9",{"v":2,"d":"2.00"},5.74,"<1","N/A","http://www.selleckchem.com/products/chelerythrine.html","C21H18NO4","Free Base","Toddaline, Broussonpapyrine","COC1=C(OC)C2=C[N+](=C3C(=C2C=C1)C=CC4=CC5=C(OCO5)C=C34)C",{"v":4.19,"d":"4.190"},4,0,2]
["E0524","Spinosad","e5","L3000-55","in 2mM DMSO","AChR,Anti-infection","Neuronal Signaling","Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete, is a biological neurotoxic insecticide with a broader action spectrum, targeting the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system.",731.96,"168316-95-8",{"v":3,"d":"3.00"},{"v":4.1,"d":"4.10"},"<1","N/A","http://www.selleckchem.com/products/spinosad.html","C41H65NO10","free base","N/A","NA","NA","NA","NA","NA"]
["S3309","Solasodine","f5","L3000-55","in 2mM DMSO","Akt,MicroRNA,MMP,PI3K","Proteases","Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.",413.64,"126-17-0",{"v":2,"d":"2.00"},4.84,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/solasodine.html","C27H43NO2","free base","Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine","CC1CCC2(NC1)OC3CC4C5CC=C6CC(O)CCC6(C)C5CCC4(C)C3C2C",4.367,1,2,0]
["S7178","Prexasertib HCl (LY2606368)","g5","L3000-55","in 2mM DMSO","Chk","Cell Cycle","Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay.",438.31,"1234015-54-3",{"v":2,"d":"2.00"},4.56,"<1","N/A","http://www.selleckchem.com/products/ly2606368.html","C18H19N7O2.2HCl","dihydrochloride","N/A","Cl.Cl.COC1=CC=CC(=C1C2=CC(=N[NH]2)NC3=NC=C(N=C3)C#N)OCCCN",2.682,5,3,8]
["S3570","ARRY-382","h5","L3000-55","in 2mM DMSO","CSF-1R","Protein Tyrosine Kinase","ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.",564.68,"1313407-95-2",{"v":5,"d":"5.00"},8.85,"<1","N/A","http://www.selleckchem.com/products/arry-382.html","C32H36N8O2","Free base","N/A","CN1CCN(CCOC2=CC3=NC=C([N]3C=C2)C(=O)NC4=C5C(=CC=C4)[N](CC6=CC=CC(=N6)C)N=C5C7CC7)CC1",3.684,5,1,9]
["S6385","Prexasertib (LY2606368)","a6","L3000-55","in 2mM DMSO","Chk,S6 Kinase","Cell Cycle","Prexasertib (LY2606368, ACR 368) is a selective ATP competitor inhibitor of Chk1 and Chk2 with IC50s of 1 nM and 8 nM in cell-free assays, respectively. Prexasertib also inhibits RSK1 with an IC50 of 9 nM in cell-free assay.",365.39,"1234015-52-1",{"v":3,"d":"3.00"},8.21,"<1","N/A","http://www.selleckchem.com/products/prexasertib-ly2606368.html","C18H19N7O2","Free base","ACR 368","COC1=C(C2=CC(=N[NH]2)NC3=CN=C(C=N3)C#N)C(=CC=C1)OCCCN",1.918,5,3,8]
["S6937","BI-3802","b6","L3000-55","in 2mM DMSO","Bcl-6","Apoptosis","BI-3802 is a highly potent oncogenic transcription factor BCL6 degrader with strong de-repression of target genes anti-proliferative effects. BI-3802 inhibits the BTB domain of BCL6 with IC50 of ≤3 nM. BI-3802 exhibits antitumor activity.",484.98,"2166387-65-9",{"v":3,"d":"3.00"},6.19,"<1","N/A","http://www.selleckchem.com/products/bi-3802.html","C24H29ClN6O3","Free base","N/A","CNC(=O)COC1=CC2=C(C=CC(=C2)NC3=NC(=NC=C3Cl)N4CC(C)CC(C)C4)N(C)C1=O",{"v":3.42,"d":"3.420"},5,2,6]
["S7089","SM-164","c6","L3000-55","in 2mM DMSO","IAP","Apoptosis","SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces apoptosis and tumor regression.",1121.42,"957135-43-2",{"v":3,"d":"3.00"},2.68,"<1","N/A","http://www.selleckchem.com/products/sm-164.html","C62H84N14O6","Free base","N/A","CNC(C)C(=O)NC1CCCCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=C[N](CCCCC5=CC=C(CCCC[N]6C=C(N=N6)C(NC(=O)C7CCC8CCCCC(NC(=O)C(C)NC)C(=O)N78)C9=CC=CC=C9)C=C5)N=N4",6.779,10,6,24]
["S9826","TPX-0046","d6","L3000-55","in 2mM DMSO","c-RET,Src","Protein Tyrosine Kinase","TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.",424.43,"2359650-19-2",{"v":2,"d":"2.00"},4.71,"<1","N/A","http://www.selleckchem.com/products/tpx-0046.html","C21H21FN6O3","Free base","N/A","CC1CNC(=O)C2=C3N=C4N(CC5=C(O1)N=CC(=C5)F)C6CCCC6OC4=C[N]3N=C2",2.146,6,1,0]
["S9872","AG-270","e6","L3000-55","in 2mM DMSO","MAT2A","Methylation","AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels  and MTAP-null–selective antiproliferative activity.",489.57,"2201056-66-6",{"v":3,"d":"3.00"},6.13,"<1","N/A","https://www.selleckchem.com/products/ag-270.html","C30H27N5O2","Free base","N/A","COC1=CC=C(C=C1)C2=C(NC3=CC=CC=N3)NC4=C(C5=CCCCC5)C(=N[N]4C2=O)C6=CC=CC=C6",6.837,4,2,6]
["S4586","4-Chloro-DL-phenylalanine","f6","L3000-55","in 2mM DMSO","Hydroxylase","Metabolism","4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase,  a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.",199.63,"7424-00-2","N/A",{"v":2,"d":"2.00"},"N/A","N/A","http://selleckchem.com/products/4-chloro-dl-phenylalanine.html","C9H10ClNO2","Free Base","Fenclonine, PCPA, CP-10188","NC(CC1=CC=C(Cl)C=C1)C(O)=O",-0.941,1,1,3]
["E1484","PDS-0330","g6","L3000-55","in 2mM DMSO","Others","Others","PDS-0330 is an inhibitor of Claudin-1, which inhibits claudin1-mediated signalling by interfering with its binding to Src. PDS-0330 exhibits an antitumor effect and enhances apoptosis in colorectal cancer cells.",423.49,"2904682-19-3",{"v":3,"d":"3.00"},7.08,"<1","N/A","https://www.selleckchem.com/products/pds-0330.html","C25H17N3O2S","free base","N/A","O=C(NC(=S)NC1=CC=C(C=C1)C2=NC3=CC=CC=C3O2)C4=CC5=C(C=CC=C5)C=C4",6.125,3,2,5]
["E1678","SPOP-i-6lc","h6","L3000-55","in 2mM DMSO","E3 Ligase","Ubiquitin","SPOP-i-6lc is a selective speckle-type POZ protein (SPOP) E3 ubiquitin ligase inhibitor with IC50 of 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively. In vitro, It suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines.",505.64,"2136270-56-7",{"v":5,"d":"5.00"},9.89,"<1","N/A","https://www.selleckchem.com/products/spop-i-6lc.html","C26H31N7O2S","free base","N/A","CN1CCN(CCNC(=O)C2=CC3=C(N=C4N(C=CC=C4C)C3=O)N(CCC5=CC=CS5)C2=N)CC1",1.368,3,1,7]
["S1911","Disodium Cromoglycate","a2","L3000-56","in 2mM Water","Calcium Channel","Transmembrane Transporters","Disodium Cromoglycate (Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium) is an antiallergic drug with IC50 of 39 μg/mL.",512.33,"15826-37-6","<1","N/A",{"v":2,"d":"2.00"},{"v":3.9,"d":"3.90"},"http://selleckchem.com/products/disodium-Cromoglycate.html","C23H14O11.2Na","Disodium Salt","Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium","[Na+].[Na+].OC(COC1=C2C(=O)C=C(OC2=CC=C1)C([O-])=O)COC3=CC=CC4=C3C(=O)C=C(O4)C([O-])=O",-1.178,6,1,8]
["S2106","Azasetron HCl","b2","L3000-56","in 2mM Water","5-HT Receptor","Neuronal Signaling","Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.",386.27,"123040-16-4","<1","N/A",{"v":3,"d":"3.00"},7.77,"http://selleckchem.com/products/azasetron-hcl.html","C17H20ClN3O3.HCl","HCl","Y-25130 HCl","Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC3CN4CCC3CC4",1.616,3,1,2]
["S2562","Hydralazine HCl","c2","L3000-56","in 2mM Water","Potassium Channel","Transmembrane Transporters","Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.",196.64,"304-20-1","<1","N/A",{"v":1,"d":"1.00"},5.09,"http://selleckchem.com/products/Hydralazine-hydrochloride.html","C8H8N4.HCl","Hydrochloride","N/A","Cl.N/N=C/1NN=CC2=C1C=CC=C2",0.798,2,2,0]
["S4067","Deferiprone","d2","L3000-56","in 2mM Water","Others","Others","Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.",139.15,"30652-11-0","<1","N/A",{"v":1,"d":"1.00"},7.19,"http://selleckchem.com/products/deferiprone.html","C7H9NO2","Free Base","CP20","CN1C=CC(=O)C(=C1C)O",-0.139,1,1,0]
["S4226","Minocycline (CL 59806) HCl","e2","L3000-56","in 2mM Water","Antibiotics","Microbiology","Minocycline (CL 59806,Minocin) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.",493.94,"13614-98-7","<1","N/A",{"v":1,"d":"1.00"},2.02,"http://selleckchem.com/products/minocycline-hcl.html","C23H27N3O7.HCl","Hydrochloride","Minocin","Cl.CN(C)C1C2CC3CC4=C(C(=CC=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["S4694","Alosetron Hydrochloride","f2","L3000-56","in 2mM Water","5-HT Receptor","Neuronal Signaling","Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.",330.81,"122852-69-1","<1","N/A",{"v":1,"d":"1.00"},3.02,"http://selleckchem.com/products/alosetron-hydrochloride.html","C17H18N4O.HCl","hydrochloride","GR 68755C, GR 68755, GR 68755X, Lotronex, GR-68755, GR68755","Cl.C[N]1C2=C(C(=O)N(CC2)CC3=C(C)N=C[NH]3)C4=C1C=CC=C4",2.036,2,1,2]
["S8030","Plerixafor (AMD3100)","g2","L3000-56","in 2mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.",502.78,"110078-46-1","<1","N/A",{"v":3,"d":"3.00"},5.97,"http://selleckchem.com/products/plerixafor.html","C28H54N8","Free Base","JM 3100, SID791","C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",{"v":-0.52,"d":"-0.520"},0,6,4]
["S5650","Sodium Hyaluronate","h2","L3000-56","in 2mM Water","Others","Others","Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans.",{"v":401.3,"d":"401.30"},"9067-32-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A",{"v":2,"d":"2.00"},"https://www.selleckchem.com/products/sodium-hyaluronate.html","C14H20NNaO11R","free base","N/A","[Na+].CC(=O)NC1C(C(O)C(CO)OC1OC2C(O)C(O)C(O[*])OC2C([O-])=O)[*]",-4.314,5,5,6]
["S2095","Fosinopril Sodium","a3","L3000-56","in 2mM Water","ACE,RAAS","Endocrinology & Hormones","Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.",585.64,"88889-14-9","N/A","N/A","N/A",{"v":2,"d":"2.00"},"http://selleckchem.com/products/fosinopril-sodium-monopril.html","C30H45NO7P.Na","Sodium Salt","SQ28555","[Na+].CCC(=O)OC(O[P](=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C([O-])=O)C3CCCCC3)C(C)C",4.129,5,0,15]