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72,11,873,11],[877,1,877,13],[879,1,880,1],[879,2,880,2],[881,1,882,1],[881,2,882,2],[883,1,884,1],[883,2,884,2],[885,1,886,1],[885,2,886,2],[887,1,888,1],[887,2,888,2],[889,1,890,1],[889,2,890,2],[891,1,892,1],[891,2,892,2],[893,1,894,1],[893,2,894,2],[898,1,898,13],[900,1,901,1],[900,2,901,2],[902,1,903,1],[902,2,903,2],[904,1,905,1],[904,2,905,2],[906,1,907,1],[906,2,907,2],[908,1,909,1],[908,2,909,2],[910,1,911,1],[910,2,911,2],[912,1,913,1],[912,2,913,2],[914,1,915,1],[914,2,915,2],[919,1,919,13],[921,1,922,1],[921,2,922,2],[921,11,922,11],[923,1,924,1],[923,2,924,2],[923,11,924,11],[925,1,926,1],[925,2,926,2],[925,11,926,11],[927,1,928,1],[927,2,928,2],[927,10,928,10],[929,1,930,1],[929,2,930,2],[929,10,930,10],[931,1,932,1],[931,2,932,2],[931,10,932,10],[933,1,934,1],[933,2,934,2],[933,10,934,10],[935,1,936,1],[935,2,936,2],[935,10,936,10],[940,1,940,13],[942,1,943,1],[942,2,943,2],[944,1,945,1],[944,2,945,2],[946,1,947,1],[946,2,947,2],[948,1,949,1],[948,2,949,2],[950,1,951,1],[950,2,951,2],[952,1,953,1],[952,2,953,2],[954,1,955,1],[954,2,955,2],[956,1,957,1],[956,2,957,2],[961,1,961,13],[963,1,964,1],[963,2,964,2],[963,6,964,6],[963,7,964,7],[963,8,964,8],[963,9,964,9],[963,10,964,10],[965,1,966,1],[965,2,966,2],[965,6,966,6],[965,7,966,7],[965,8,966,8],[965,9,966,9],[965,10,966,10],[967,1,968,1],[967,2,968,2],[967,6,968,6],[967,7,968,7],[967,8,968,8],[967,9,968,9],[967,10,968,10],[969,1,970,1],[969,2,970,2],[969,6,970,6],[969,7,970,7],[969,8,970,8],[969,9,970,9],[969,10,970,10],[971,1,972,1],[971,2,972,2],[971,5,972,5],[971,6,972,6],[971,7,972,7],[971,8,972,8],[971,9,972,9],[971,10,972,10],[973,1,974,1],[973,2,974,2],[973,5,974,5],[973,6,974,6],[973,7,974,7],[973,8,974,8],[973,9,974,9],[973,10,974,10],[975,1,976,1],[975,2,976,2],[975,5,976,5],[975,6,976,6],[975,7,976,7],[975,8,976,8],[975,9,976,9],[975,10,976,10],[977,1,978,1],[977,2,978,2],[977,5,978,5],[977,6,978,6],[977,7,978,7],[977,8,978,8],[977,9,978,9],[977,10,978,10],[982,1,982,13],[984,1,985,1],[984,2,985,2],[984,6,985,6],[984,7,985,7],[984,8,985,8],[984,9,985,9],[984,10,985,10],[986,1,987,1],[986,2,987,2],[986,5,987,5],[986,6,987,6],[986,7,987,7],[986,8,987,8],[986,9,987,9],[986,10,987,10],[988,1,989,1],[988,2,989,2],[988,5,989,5],[988,6,989,6],[988,7,989,7],[988,8,989,8],[988,9,989,9],[988,10,989,10],[990,1,991,1],[990,2,991,2],[990,5,991,5],[990,6,991,6],[990,7,991,7],[990,8,991,8],[990,9,991,9],[990,10,991,10],[992,1,993,1],[992,2,993,2],[992,5,993,5],[992,6,993,6],[992,7,993,7],[992,8,993,8],[992,9,993,9],[992,10,993,10],[994,1,995,1],[994,2,995,2],[994,5,995,5],[994,6,995,6],[994,7,995,7],[994,8,995,8],[994,9,995,9],[994,10,995,10],[996,1,997,1],[996,2,997,2],[996,5,997,5],[996,6,997,6],[996,7,997,7],[996,8,997,8],[996,9,997,9],[996,10,997,10],[998,1,999,1],[998,2,999,2],[998,5,999,5],[998,6,999,6],[998,7,999,7],[998,8,999,8],[998,9,999,9],[998,10,999,10],[1003,1,1003,13],[1005,1,1006,1],[1005,2,1006,2],[1005,4,1006,4],[1005,5,1006,5],[1005,6,1006,6],[1005,7,1006,7],[1005,8,1006,8],[1005,9,1006,9],[1005,10,1006,10],[1007,1,1008,1],[1007,2,1008,2],[1007,3,1008,3],[1007,4,1008,4],[1007,5,1008,5],[1007,6,1008,6],[1007,7,1008,7],[1007,8,1008,8],[1007,9,1008,9],[1007,10,1008,10],[1009,1,1010,1],[1009,2,1010,2],[1009,3,1010,3],[1009,4,1010,4],[1009,5,1010,5],[1009,6,1010,6],[1009,7,1010,7],[1009,8,1010,8],[1009,9,1010,9],[1009,10,1010,10],[1011,1,1012,1],[1011,2,1012,2],[1011,3,1012,3],[1011,4,1012,4],[1011,5,1012,5],[1011,6,1012,6],[1011,7,1012,7],[1011,8,1012,8],[1011,9,1012,9],[1011,10,1012,10],[1013,1,1014,1],[1013,2,1014,2],[1013,3,1014,3],[1013,4,1014,4],[1013,5,1014,5],[1013,6,1014,6],[1013,7,1014,7],[1013,8,1014,8],[1013,9,1014,9],[1013,10,1014,10],[1015,1,1016,1],[1015,2,1016,2],[1015,3,1016,3],[1015,4,1016,4],[1015,5,1016,5],[1015,6,1016,6],[1015,7,1016,7],[1015,8,1016,8],[1015,9,1016,9],[1015,10,1016,10],[1017,1,1018,1],[1017,2,1018,2],[1017,3,1018,3],[1017,4,1018,4],[1017,5,1018,5],[1017,6,1018,6],[1017,7,1018,7],[1017,8,1018,8],[1017,9,1018,9],[1017,10,1018,10],[1019,1,1020,1],[1019,2,1020,2],[1019,3,1020,3],[1019,4,1020,4],[1019,5,1020,5],[1019,6,1020,6],[1019,7,1020,7],[1019,8,1020,8],[1019,9,1020,9],[1019,10,1020,10]],"merged_total":1455,"flags":["merged_cut"]}
[{"$nulls":3},"Preclinical/Clinical Compound Library  (96-well)-L3900"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 3603 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L3900-01~41;    In 10 mM Water : Plate layout L3900-42~44;"]
[{"$nulls":3},"In 2 mM DMSO : Plate layout L3900-45~46;    In 2 mM Water  : Plate layout L3900-47;"]
[{"$nulls":3},"In 2mg/ml DMSO : Plate layout L3900-48"]
[]
[]
[]
[null,"Plate layout: L3900-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1002","S1011","S1022","S1035","S1047","S1060","S1071","S1087","S1097","S1107","Empty"]
[{"$nulls":3},"ABT-737","Afatinib (BIBW2992)","Ridaforolimus (Deforolimus, MK-8669)","Pazopanib HCl (GW786034 HCl)","Vorinostat (SAHA)","Olaparib (AZD2281)","HA14-1","Iniparib (BSI-201)","BTZ043 Racemate","Danusertib (PHA-739358)"]
[null,"b","Empty","S1003","S1012","S1025","S1036","S1048","S1061","S1072","S1089","S1098","S1109","Empty"]
[{"$nulls":3},"Linifanib (ABT-869)","BMS-536924","Gefitinib (ZD1839)","Mirdametinib (PD0325901)","Tozasertib","Nutlin-3","ZSTK474","Refametinib (RDEA119)","Rucaparib (AG-014699) phosphate","BI 2536"]
[null,"c","Empty","S1004","S1013","S1026","S1038","S1049","S1064","S1076","S1090","S1100","S1110","Empty"]
[{"$nulls":3},"Veliparib (ABT-888)","Bortezomib (PS-341)","Imatinib (STI571) Mesylate","PI-103","Y-27632 2HCl","Masitinib (AB1010)","Adezmapimod (SB203580)","Abexinostat (PCI-24781)","MLN8054","Varespladib (LY315920)"]
[null,"d","Empty","S1005","S1014","S1028","S1039","S1052","S1065","S1078","S1091","S1101","S1111","Empty"]
[{"$nulls":3},"Axitinib (AG 013736)","Bosutinib (SKI-606)","Lapatinib (GW-572016) Ditosylate","Rapamycin (AY-22989)","Elesclomol (STA-4783)","Pictilisib (GDC-0941)","MK-2206 2HCl","Linsitinib (OSI-906)","Vatalanib (PTK787) 2HCl","Foretinib (GSK1363089)"]
[null,"e","Empty","S1006","S1017","S1029","S1040","S1053","S1067","S1080","S1092","S1102","S1113","Empty"]
[{"$nulls":3},"Saracatinib (AZD0530)","Cediranib (AZD2171)","Lenalidomide (CC-5013)","Sorafenib (BAY 43-9006) tosylate","Entinostat (MS-275)","SB431542","SU11274","KU-55933 (ATM Kinase Inhibitor)","U0126-EtOH","GSK690693"]
[null,"f","Empty","S1007","S1018","S1030","S1041","S1055","S1068","S1082","S1094","S1103","S1114","Empty"]
[{"$nulls":3},"Roxadustat (FG-4592)","Dovitinib (TKI-258)","Panobinostat (LBH589)","STF-62247","Enzastaurin (LY317615)","Crizotinib (PF-02341066)","Vismodegib (GDC-0449)","PF-04217903","ZM 447439","JNJ-38877605"]
[null,"g","Empty","S1008","S1020","S1032","S1042","S1056","S1069","S1084","S1095","S1105","S1115","Empty"]
[{"$nulls":3},"Selumetinib (AZD6244)","PD184352 (CI-1040)","Motesanib Diphosphate (AMG-706)","Sunitinib (SU11248) malate","AC480 (BMS-599626)","Luminespib (NVP-AUY922)","Brivanib (BMS-540215)","Dacinostat (LAQ824)","LY294002","Odanacatib (MK-0822)"]
[null,"h","Empty","S1010","S1021","S1033","S1044","S1057","S1070","S1085","S1096","S1106","S1117","Empty"]
[{"$nulls":3},"Nintedanib (BIBF 1120)","Dasatinib (BMS-354825)","Nilotinib (AMN-107)","Temsirolimus (CCI-779)","Obatoclax Mesylate (GX15-070)","PHA-665752","Belinostat (PXD101)","Quisinostat (JNJ-26481585) 2HCl","OSU-03012 (AR-12)","Triciribine (NSC 154020)"]
[]
[]
[]
[null,"Plate layout: L3900-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1119","S1134","S1148","S1159","S1171","S1185","S1195","S1206","S1218","S1229","Empty"]
[{"$nulls":3},"Cabozantinib (BMS-907351)","AT9283","Docetaxel (RP56976)","Ganetespib (STA-9090)","CYC116","Ritonavir (ABT-538)","Orteronel","Bisoprolol fumarate","Clofarabine","Fludarabine Phosphate"]
[null,"b","Empty","S1120","S1138","S1150","S1162","S1172","S1188","S1196","S1207","S1220","S1230","Empty"]
[{"$nulls":3},"Everolimus (RAD001)","Brivanib Alaninate (BMS-582664)","Paclitaxel (NSC 125973)","Pretomanid (PA-824)","Serdemetan (JNJ-26854165)","Anastrozole (ZD-1033)","Exemestane (FCE 24304)","Tivozanib (AV-951)","OSI-930","Flavopiridol (L86-8275)"]
[null,"c","Empty","S1122","S1141","S1152","S1163","S1175","S1189","S1197","S1208","S1221","S1231","Empty"]
[{"$nulls":3},"Mocetinostat (MGCD0103)","Tanespimycin (17-AAG)","PLX-4720","Onalespib (AT13387)","BIIB021","Aprepitant (MK-0869)","Finasteride","Doxorubicin (Adriamycin) HCl","Dacarbazine (NSC-45388)","Topotecan (NSC609699) HCl"]
[null,"d","Empty","S1124","S1142","S1153","S1164","S1176","S1190","S1199","S1209","S1222","S1233","Empty"]
[{"$nulls":3},"BMS-754807","Alvespimycin (17-DMAG) HCl","Roscovitine (CYC202)","Lenvatinib (E7080)","Plinabulin (NPI-2358)","Bicalutamide (ICI-176334)","Cladribine (RWJ 26251)","Fluorouracil (5-Fluorouracil, 5-FU)","Dexrazoxane HCl (ICRF-187)","2-Methoxyestradiol (2-MeOE2)"]
[null,"e","Empty","S1129","S1143","S1154","S1165","S1178","S1191","S1200","S1210","S1223","S1235","Empty"]
[{"$nulls":3},"SRT1720 HCl","AG-490 (Tyrphostin B42)","SNS-314","ABT-751 (E7010)","Regorafenib (BAY 73-4506)","Fulvestrant (ICI-182780)","Decitabine (NSC 127716)","Methotrexate (CL-14377)","Epirubicin (IMI 28) HCl","Letrozole (CGS 20267)"]
[null,"f","Empty","S1130","S1144","S1156","S1167","S1180","S1192","S1201","S1212","S1225","S1237","Empty"]
[{"$nulls":3},"Sepantronium Bromide","Ivacaftor (VX-770)","Capecitabine (RO 09-1978)","CP-724714","XAV-939","Raltitrexed","Dimesna","Bendamustine (SDX105) HCl","Etoposide (VP-16)","Temozolomide (CCRG 81045)"]
[null,"g","Empty","S1132","S1145","S1157","S1168","S1181","S1193","S1202","S1213","S1226","S1238","Empty"]
[{"$nulls":3},"3-Aminobenzamide","SNS-032 (BMS-387032)","Delanzomib (CEP-18770)","Valproic Acid (NSC 93819) sodium salt","ENMD-2076","Thalidomide (K17)","Dutasteride","Nelarabine","KU-0063794","Tamoxifen (ICI 46474)"]
[null,"h","Empty","S1133","S1147","S1158","S1169","S1183","S1194","S1204","S1214","S1227","S1241","Empty"]
[{"$nulls":3},"Alisertib (MLN8237)","Barasertib (AZD1152-HQPA)","MK-8245","TGX-221","Danoprevir (ITMN-191)","CUDC-101","Melatonin (NSC 113928)","Bleomycin (NSC125066) sulfate","Raloxifene HCl","Vincristine (NSC-67574) sulfate"]
[]
[]
[]
[null,"Plate layout: L3900-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1243","S1255","S1263","S1280","S1291","S1304","S1331","S1344","S1361","S1374","Empty"]
[{"$nulls":3},"Agomelatine (S20098)","Nepafenac","Laduviglusib (CHIR-99021)","Amisulpride","Cetirizine DiHCl","Megestrol Acetate","Fluconazole (UK 49858)","Glimepiride","MGCD-265 analog","Doripenem Hydrate"]
[null,"b","Empty","S1244","S1256","S1264","S1281","S1292","S1305","S1332","S1351","S1362","S1376","Empty"]
[{"$nulls":3},"Amuvatinib (MP-470)","Rufinamide","PD173074","Aniracetam","Chelerythrine Chloride (NSC 646662)","Mercaptopurine (6-MP)","Flumazenil (RO 15-1788)","Ivermectin (MK-933)","Rigosertib (ON-01910)","Gestodene"]
[null,"c","Empty","S1245","S1257","S1267","S1282","S1293","S1315","S1333","S1352","S1364","S1377","Empty"]
[{"$nulls":3},"Latrepirdine 2HCl","Posaconazole (SCH 56592)","Vemurafenib (PLX4032)","Artemisinin","Cilnidipine (FRC-8653)","Ki16425","Fluoxetine (Lilly 110140) HCl","TG100-115","Patupilone (Epothilone B)","Drospirenone"]
[null,"d","Empty","S1247","S1258","S1271","S1283","S1294","S1322","S1334","S1354","S1366","S1378","Empty"]
[{"$nulls":3},"Leflunomide (HWA486)","Prasugrel","Acarbose","Asenapine maleate","Cilostazol (OPC-13013)","Dexamethasone (MK-125)","Flupirtine maleate","Lansoprazole","BMS-707035","Ruxolitinib (INCB018424)"]
[null,"e","Empty","S1249","S1259","S1274","S1284","S1297","S1324","S1336","S1356","S1367","S1379","Empty"]
[{"$nulls":3},"JNJ-7706621","Ramelteon","BX-795","Benazepril HCl","Epothilone A","Doxazosin Mesylate","Fluvoxamine (DU-23000) maleate","Levetiracetam (UCB-L059)","Amonafide","Isotretinoin"]
[null,"f","Empty","S1250","S1260","S1275","S1286","S1299","S1326","S1340","S1357","S1368","S1380","Empty"]
[{"$nulls":3},"Enzalutamide (MDV3100)","Cinacalcet (AMG-073) HCl","BX-912","Budesonide","Floxuridine (NSC 27640)","Edaravone","Gatifloxacin","Lidocaine","Acitretin","Lopinavir (ABT-378)"]
[null,"g","Empty","S1251","S1261","S1276","S1287","S1300","S1328","S1342","S1358","S1369","S1381","Empty"]
[{"$nulls":3},"Dienogest","Celecoxib (SC 58635)","Adapalene","Bumetanide","Tegafur (FT-207)","Etodolac","Genistein (NPI 031L)","Loratadine (SCH29851)","Bafetinib (INNO-406)","Meropenem"]
[null,"h","Empty","S1252","S1262","S1278","S1290","S1302","S1330","S1343","S1359","S1373","S1382","Empty"]
[{"$nulls":3},"Entecavir Hydrate","Avagacestat (BMS-708163)","Altretamine","Celastrol (NSC 70931)","Ifosfamide (NSC109724)","Felbamate","Ginkgolide B","Losartan Potassium (DuP 753)","Daptomycin (LY146032)","Mianserin HCl"]
[]
[]
[]
[null,"Plate layout: L3900-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1386","S1396","S1407","S1432","S1444","S1458","S1475","S1488","S1508","S1526","Empty"]
[{"$nulls":3},"Nafamostat mesilate (FUT-175)","Resveratrol (SRT501)","Bimatoprost","Sumatriptan Succinate","Ziprasidone HCl","Neflamapimod (VX-745)","Pimasertib (AS-703026)","Naratriptan HCl","Alprostadil","Quizartinib (AC220)"]
[null,"b","Empty","S1387","S1397","S1408","S1435","S1445","S1460","S1480","S1490","S1511","S1528","Empty"]
[{"$nulls":3},"Naftopidil DiHCl","Rocuronium Bromide","Linezolid (PNU-100766)","Tamsulosin hydrochloride","Zonisamide","SP600125","Lomibuvir (VX-222)","Ponatinib (AP24534)","Lactulose","LY2811376"]
[null,"c","Empty","S1389","S1398","S1409","S1437","S1452","S1462","S1481","S1491","S1512","S1532","Empty"]
[{"$nulls":3},"Omeprazole","Stavudine (d4T)","Alfuzosin HCl","Tizanidine HCl","Ispinesib (SB-715992)","AZD6482","Zosuquidar (LY335979) 3HCl","Fludarabine (NSC 118218)","Tadalafil (IC351)","AZD7762"]
[null,"d","Empty","S1390","S1400","S1415","S1438","S1453","S1465","S1482","S1497","S1514","S1533","Empty"]
[{"$nulls":3},"Ondansetron HCl","Tenofovir (GS 1278) Disoproxil Fumarate","Clopidogrel (SR-25990C) Bisulfate","Topiramate","Tipifarnib (R115777)","Moxifloxacin (BAY12-8039) HCl","Daclatasvir (BMS-790052)","Pralatrexate (NSC 754230)","Cyclosporine","R406 (free base)"]
[null,"e","Empty","S1391","S1401","S1425","S1439","S1454","S1467","S1483","S1499","S1515","S1536","Empty"]
[{"$nulls":3},"Oxcarbazepine","Tenofovir","Ranolazine 2HCl","Tranilast (SB 252218)","PHA-680632","Doxercalciferol","Iloperidone","Cefaclor","Pracinostat (SB939)","CP-673451"]
[null,"f","Empty","S1392","S1403","S1426","S1441","S1455","S1468","S1485","S1500","S1517","S1537","Empty"]
[{"$nulls":3},"Pelitinib (EKB-569)","Tigecycline (GAR-936)","Repaglinide","Venlafaxine HCl","Cilomilast","Alfacalcidol","HMN-214","Betamethasone","Natamycin","Vadimezan (ASA404)"]
[null,"g","Empty","S1393","S1404","S1430","S1442","S1456","S1470","S1486","S1501","S1524","S1538","Empty"]
[{"$nulls":3},"Pirarubicin (NSC-333054)","Trilostane","Rolipram (ZK-62711)","Voriconazole (UK-109496)","Zibotentan (ZD4054)","Orantinib (SU6668)","AEE788 (NVP-AEE788)","Mycophenolate mofetil (RS-61443)","AT7519","Telaprevir (VX-950)"]
[null,"h","Empty","S1394","S1405","S1431","S1443","S1457","S1472","S1487","S1505","S1525","S1540","Empty"]
[{"$nulls":3},"Pizotifen Malate","Vecuronium Bromide","Sildenafil Citrate","Zileuton (A-64077)","Atazanavir (BMS-232632) Sulfate","Safinamide Mesylate","PHA-793887","Aztreonam","Adavosertib (MK-1775)","Saxagliptin (BMS-477118)"]
[]
[]
[]
[null,"Plate layout: L3900-05"]
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[null,"a","Empty","S1541","S1557","S1576","S1605","S1614","S1629","S1640","S1653","S1669","S1683","Empty"]
[{"$nulls":3},"Selisistat (EX 527)","KRN 633","Sulfasalazine (NSC 667219)","Cefdinir","Riluzole (PK 26124)","Orlistat (Ro 18-0647)","Albendazole (SKF-62979)","Tretinoin (NSC 122758)","Loteprednol etabonate","Ipratropium Bromide"]
[null,"b","Empty","S1547","S1558","S1578","S1606","S1619","S1630","S1641","S1655","S1673","S1685","Empty"]
[{"$nulls":3},"Febuxostat","AT7867","Candesartan (CV-11974)","Clotrimazole","Prilocaine","Allopurinol","Chlorothiazide","Ezetimibe (SCH-58235)","Aminophylline","Sulfanilamide"]
[null,"c","Empty","S1548","S1561","S1591","S1607","S1620","S1631","S1643","S1657","S1675","S1688","Empty"]
[{"$nulls":3},"Dapagliflozin (BMS-512148)","BMS-777607","Bestatin (NK421)","Rizatriptan Benzoate","Darunavir Ethanolate","Allopurinol Sodium","Ursodiol","Enalaprilat Dihydrate","Lubiprostone","Betamethasone Dipropionate"]
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[{"$nulls":3},"Nebivolol hydrochloride (R-65824)","Lumacaftor (VX-809)","Apixaban (BMS 562247-01)","Pyridostigmine Bromide","Prednisone (NSC-10023)","Zafirlukast (ICI-204219)","Ketoprofen","Dofetilide","Amorolfine HCl","Betamethasone Valerate"]
[null,"e","Empty","S1550","S1567","S1594","S1609","S1625","S1635","S1646","S1662","S1677","S1691","Empty"]
[{"$nulls":3},"Pimobendan","Pomalidomide (CC-4047)","Semagacestat (LY450139)","Methimazole","Ethinyl Estradiol","Erythromycin","Ketorolac","Isradipine","Chloramphenicol","Praziquantel"]
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[{"$nulls":3},"Delafloxacin (ABT-492)","Tazarotene","Reserpine","Metolazone","Naproxen Sodium","Amphotericin B","Adenosine","Estrone","Flurbiprofen","Busulfan (NSC-750)"]
[null,"g","Empty","S1555","S1573","S1603","S1611","S1627","S1638","S1649","S1666","S1680","S1693","Empty"]
[{"$nulls":3},"AZD8055","Fasudil (HA-1077) HCl","Furosemide (NSC 269420)","Cefoperazone","Nitazoxanide (NSC 697855)","Ibuprofen (NSC 256857)","Zolmitriptan","Flucytosine","Disulfiram (NSC 190940)","Carbamazepine"]
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[{"$nulls":3},"PHT-427","Doramapimod (BIRB 796)","Olmesartan Medoxomil","Silodosin","Triamcinolone Acetonide","Amprenavir (VX-478)","Telbivudine","Trichlormethiazide","Mesalamine (5-ASA)","Hydrocortisone (NSC 10483)"]
[]
[]
[]
[null,"Plate layout: L3900-06"]
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[null,"a","Empty","S1701","S1713","S1723","S1735","S1744","S1764","S1777","S1792","S1808","S1830","Empty"]
[{"$nulls":3},"Desonide","Piroxicam","Indomethacin (NSC-77541)","Mesna","Nicotinic Acid","Rifampin (NSC-113926)","Ethionamide","Simvastatin (MK 733)","Nifedipine (BAY-a-1040)","Oxfendazole"]
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[{"$nulls":3},"Didanosine","Gemcitabine (LY-188011)","Terbinafine","Methocarbamol","Nimodipine","Cefditoren Pivoxil","Trifluridine (NSC 75520)","Ramipril","Amiloride (MK-870) HCl","Carvedilol"]
[null,"c","Empty","S1703","S1715","S1727","S1737","S1748","S1770","S1782","S1794","S1813","S1832","Empty"]
[{"$nulls":3},"Divalproex Sodium","Glipizide","Levonorgestrel","Prednisolone (NSC-9900)","Nisoldipine","Sulfadiazine","Azacitidine (5-Azacytidine)","Fenofibrate (NSC-281319)","Amlodipine Besylate","Atracurium Besylate"]
[null,"d","Empty","S1704","S1716","S1729","S1738","S1754","S1771","S1784","S1799","S1816","S1833","Empty"]
[{"$nulls":3},"Emtricitabine (BW 1592)","Glyburide (Glibenclamide)","Gemfibrozil","Telmisartan","Oxybutynin","Chlorprothixene","Vidarabine","Ranolazine","Chlorpheniramine Maleate","Butoconazole nitrate"]
[null,"e","Empty","S1705","S1717","S1730","S1740","S1759","S1773","S1786","S1801","S1825","S1835","Empty"]
[{"$nulls":3},"Progesterone (NSC 9704)","Fomepizole","Indapamide","Guaifenesin","Pitavastatin (NK-104) calcium","Oxytetracycline (Terramycin)","Verteporfin (CL 318952)","Ranitidine Hydrochloride","Erdosteine","Azithromycin (CP-62993)"]
[null,"f","Empty","S1706","S1718","S1732","S1741","S1760","S1774","S1787","S1802","S1827","S1840","Empty"]
[{"$nulls":3},"Lamivudine (BCH-189)","Adefovir Dipivoxil (GS 0840)","Mitotane","Rifabutin (LM427)","Rifapentine","Thioguanine (NSC 752)","Teniposide","AICAR (Acadesine)","Betaxolol HCl","Lomustine"]
[null,"g","Empty","S1709","S1719","S1733","S1742","S1762","S1775","S1789","S1806","S1828","S1843","Empty"]
[{"$nulls":3},"Estradiol","Zalcitabine","Methylprednisolone (NSC-19987)","Nevirapine (NSC 641530)","Pyrazinamide","Thiotepa","Tetrabenazine (Xenazine)","Acipimox","Proparacaine HCl","Chenodeoxycholic Acid"]
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[{"$nulls":3},"Deferasirox (ICL-670)","Azathioprine","Meloxicam","Esomeprazole magnesium","Quetiapine (ICI-204636) fumarate","Toremifene Citrate (NK 622)","Rifaximin","Aciclovir (BW 248U)","Pranlukast","Cimetidine"]
[]
[]
[]
[null,"Plate layout: L3900-07"]
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[{"$nulls":3},"Clemastine (HS-592) fumarate","Dapoxetine HCl","Carbidopa","Amlodipine","Phenindione","Methoxsalen","Nicorandil","Fluticasone propionate","PCI-34051","Ketotifen Fumarate"]
[null,"b","Empty","S1848","S1876","S1894","S1907","S1933","S1956","S1972","S1994","S2013","S2025","Empty"]
[{"$nulls":3},"Curcumin","Valaciclovir HCl","Valsartan (CGP-48933)","Metronidazole","Triamcinolone","Miconazole Nitrate","Tamoxifen (ICI 46474) Citrate","Lacidipine","PF-573228","Urapidil HCl"]
[null,"c","Empty","S1849","S1878","S1895","S1908","S1934","S1958","S1975","S2001","S2014","S2029","Empty"]
[{"$nulls":3},"Daidzein","Ganciclovir (BW 759)","Dipyridamole (NSC 515776)","Flutamide","Nystatin (Fungicidin)","Sulbactam","Aripiprazole","Elvitegravir (JTK-303)","BMS-265246","Uridine"]
[null,"d","Empty","S1854","S1883","S1896","S1909","S1937","S1959","S1979","S2003","S2015","S2030","Empty"]
[{"$nulls":3},"Bifonazole","Idoxuridine","Hydroxyurea (NSC-32065)","Fluvastatin (XU-62-320) Sodium","Isoniazid","Tolfenamic Acid","Amiodarone (NSC 85442) HCl","Maraviroc (UK-427857)","Suplatast Tosylate","Flunarizine 2HCl"]
[null,"e","Empty","S1856","S1884","S1897","S1913","S1940","S1960","S1983","S2005","S2016","S2032","Empty"]
[{"$nulls":3},"Metoprolol Tartrate","Sparfloxacin","Potassium Iodide","Tropicamide","Levofloxacin","Pranoprofen","Adenine HCl","Raltegravir (MK-0518)","Mirtazapine","Rebamipide"]
[null,"f","Empty","S1859","S1885","S1898","S1914","S1941","S1964","S1987","S2006","S2017","S2036","Empty"]
[{"$nulls":3},"Diethylstilbestrol","Felodipine","Tropisetron HCl","Pregnenolone","Enalapril Maleate","Rimantadine","Mometasone furoate","Pyrimethamine","Benidipine HCl","Aspartame"]
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[{"$nulls":3},"Diltiazem HCl","Deflazacort","Nicotinamide (NSC 13128)","Sulfamethoxazole","Menadione (NSC 4170)","Primidone","Propylthiouracil","Sulindac","ENMD-2076 L-(+)-Tartaric acid","Candesartan Cilexetil"]
[null,"h","Empty","S1866","S1890","S1903","S1920","S1950","S1969","S1990","S2011","S2020","S2038","Empty"]
[{"$nulls":3},"Diphenhydramine HCl","Nizatidine","Diclofenac Sodium","Haloperidol","Metformin HCl","Nefiracetam","Capsaicin(Vanilloid)","Pramipexole 2HCl Monohydrate","Formoterol Hemifumarate","Phentolamine Mesylate"]
[]
[]
[]
[null,"Plate layout: L3900-08"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2040","S2052","S2064","S2077","S2087","S2102","S2116","S2131","S2158","S2173","Empty"]
[{"$nulls":3},"Nimesulide","Oxytetracycline Dihydrate","Balofloxacin","Atorvastatin Calcium","Rivastigmine Tartrate","Rasagiline Mesylate","Conivaptan HCl","Roflumilast (B9302-107)","KW-2449","Telotristat Etiprate (LX 1606 Hippurate)"]
[null,"b","Empty","S2041","S2054","S2065","S2078","S2090","S2103","S2118","S2134","S2159","S2177","Empty"]
[{"$nulls":3},"Dyclonine HCl","Orphenadrine Citrate","Lafutidine","Famotidine","Dexmedetomidine HCl","Naltrexone HCl","Ibutilide Fumarate","AZD8330","Tebipenem Pivoxil","Dichlorphenamide"]
[null,"c","Empty","S2042","S2055","S2066","S2079","S2091","S2104","S2119","S2149","S2160","S2178","Empty"]
[{"$nulls":3},"Cyproterone Acetate","Gimeracil","Moxonidine","Moexipril HCl","Betaxolol","Levosulpiride","Probucol","GSK1292263","Almorexant HCl","AG-14361"]
[null,"d","Empty","S2043","S2057","S2067","S2080","S2096","S2105","S2123","S2151","S2161","S2179","Empty"]
[{"$nulls":3},"Memantine HCl","Cyclophosphamide (NSC-26271) Monohydrate","Ozagrel HCl","Clevidipine Butyrate","Almotriptan Malate","Pantoprazole","Dextrose","Sonidegib (NVP-LDE225)","RAF265 (CHIR-265)","Gandotinib (LY2784544)"]
[null,"e","Empty","S2044","S2059","S2069","S2083","S2097","S2109","S2126","S2153","S2162","S2180","Empty"]
[{"$nulls":3},"Cyproheptadine HCl","Terazosin HCl Dihydrate","Argatroban (MCI-9038)","Procaterol HCl","Ambrisentan","Imidapril HCl","Naftopidil","CGS 21680 HCl","AZD1480","Ixazomib (MLN2238)"]
[null,"f","Empty","S2045","S2060","S2071","S2084","S2098","S2111","S2127","S2154","S2167","S2181","Empty"]
[{"$nulls":3},"Doxifluridine","Bromhexine HCl","Prulifloxacin (NM441)","Duloxetine HCl","Bexarotene (LGD1069)","Lapatinib (GW-572016)","S-(+)-Rolipram","Dabigatran (BIBR-1048) etexilate","Bazedoxifene (TSE-424) acetate","Ixazomib Citrate (MLN9708) Analogue"]
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[{"$nulls":3},"Pioglitazone HCl","Lovastatin (MK-803)","Seratrodast(AA-2414)","Trimebutine","Temocapril HCl","Cisatracurium Besylate","Bazedoxifene (WAY-140424) HCl","LY2608204","Rosuvastatin (ZD4522) calcium","SB743921 HCl"]
[null,"h","Empty","S2051","S2062","S2075","S2086","S2101","S2114","S2130","S2156","S2170","S2183","Empty"]
[{"$nulls":3},"Captopril","Tiopronin","Rosiglitazone (BRL-49653) HCl","Ivabradine HCl","Gabexate Mesylate","Dronedarone HCl","Atropine sulfate monohydrate","LY2886721","Givinostat (ITF2357)","Infigratinib (BGJ398)"]
[]
[]
[]
[null,"Plate layout: L3900-09"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2185","S2199","S2224","S2238","S2261","S2277","S2295","S2311","S2321","S2344","Empty"]
[{"$nulls":3},"Allitinib tosylate","Aliskiren Hemifumarate","UK 383367","Palomid 529 (P529)","Andrographolide","Caffeic Acid","Emodin","Hyodeoxycholic acid (HDCA)","Magnolol","Piperine"]
[null,"b","Empty","S2186","S2201","S2226","S2243","S2262","S2280","S2298","S2312","S2323","S2346","Empty"]
[{"$nulls":3},"SB505124","BMS-794833","Idelalisib","Degrasyn (WP1130)","Apigenin (LY 080400)","Chlorogenic Acid","Fisetin","Icariin","Methyl-Hesperidin","Puerarin"]
[null,"c","Empty","S2187","S2214","S2228","S2244","S2264","S2283","S2302","S2313","S2329","S2347","Empty"]
[{"$nulls":3},"Avasimibe (CI-1011)","AZ 960","Belnacasan (VX-765)","AR-42","Artemether","Cinchonine(LA40221)","Glycyrrhizin (NSC 167409)","Indole-3-carbinol","Naringin","Quercetin Dihydrate"]
[null,"d","Empty","S2192","S2215","S2229","S2246","S2265","S2284","S2303","S2314","S2334","S2350","Empty"]
[{"$nulls":3},"Sapitinib (AZD8931)","DAPT (GSI-IX)","Eltrombopag (SB497115) Olamine","Abiraterone Acetate (CB7630)","Artesunate (WR-256283)","Colchicine (NSC 757)","Gossypol Acetate","Kaempferol (NSC 407289)","Oleanolic Acid","Rutin"]
[null,"e","Empty","S2193","S2216","S2230","S2247","S2268","S2286","S2305","S2316","S2335","S2357","Empty"]
[{"$nulls":3},"GSK461364","Mubritinib (TAK 165)","Galunisertib (LY2157299)","Buparlisib (BKM120)","Baicalein","Cyclosporin A (NSC 290193)","Grape Seed Extract","Kinetin","Oridonin (NSC-250682)","Silibinin (NSC 651520)"]
[null,"f","Empty","S2194","S2217","S2231","S2248","S2269","S2287","S2308","S2317","S2336","S2358","Empty"]
[{"$nulls":3},"R406","Irinotecan (CPT-11) HCl Trihydrate","Telatinib","Silmitasertib (CX-4945)","Baicalin (NSC-661431)","Cytisine","Hesperetin","L-(+)-Rhamnose Monohydrate","Orotic acid (6-Carboxyuracil)","Silymarin"]
[null,"g","Empty","S2195","S2219","S2233","S2250","S2271","S2289","S2309","S2318","S2337","S2359","Empty"]
[{"$nulls":3},"Lexibulin (CYT997)","Momelotinib (CYT387)","Esomeprazole sodium","(-)-Epigallocatechin Gallate","Berberine chloride (NSC 646666)","Daidzin","Hesperidin","Lappaconitine","Osthole","Sinomenine"]
[null,"h","Empty","S2198","S2220","S2235","S2258","S2276","S2290","S2310","S2320","S2341","S2363","Empty"]
[{"$nulls":3},"SGI-1776 free base","SB590885","Volasertib (BI 6727)","Esculin","Bilobalide","Dihydroartemisinin (DHA)","Honokiol (NSC 293100)","Luteolin","(-)-Parthenolide","Tangeretin"]
[]
[]
[]
[null,"Plate layout: L3900-10"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2365","S2388","S2407","S2443","S2455","S2467","S2484","S2497","S2506","S2521","Empty"]
[{"$nulls":3},"Tanshinone IIA","L-carnitine","Curcumol","Tolbutamide (HLS 831)","Bethanechol chloride","Famciclovir","Milrinone","Pancuronium dibromide","Roxithromycin","Epinephrine bitartrate"]
[null,"b","Empty","S2369","S2389","S2410","S2446","S2456","S2470","S2485","S2499","S2508","S2524","Empty"]
[{"$nulls":3},"Troxerutin","Naringin Dihydrochalcone","Paeoniflorin (NSC 178886)","Levosimendan","Chlorpromazine HCl","Fluocinolone Acetonide","Mitoxantrone (NSC-301739) 2HCl","Phenoxybenzamine HCl","Scopolamine (LSM-4015) HBr","Phenytoin Sodium"]
[null,"c","Empty","S2370","S2391","S2411","S2448","S2457","S2473","S2487","S2500","S2509","S2525","Empty"]
[{"$nulls":3},"Ursolic Acid","Quercetin (NSC 9221)","Geniposide","Gambogic Acid","Clindamycin HCl","Hexestrol","Mycophenolic acid","Propafenone HCl","Sotalol HCl","Phenytoin"]
[null,"d","Empty","S2374","S2393","S2412","S2449","S2458","S2475","S2489","S2501","S2510","S2528","Empty"]
[{"$nulls":3},"5-hydroxytryptophan (5-HTP)","Sorbitol","Genipin","Colforsin","Clonidine HCl","Imatinib (STI571)","Nateglinide","Pyrantel Pamoate","Spectinomycin 2HCl","Ciclopirox"]
[null,"e","Empty","S2381","S2394","S2423","S2450","S2459","S2479","S2491","S2502","S2511","S2529","Empty"]
[{"$nulls":3},"D-Mannitol","Naringenin","(S)-10-Hydroxycamptothecin","Equol","Clozapine","Lincomycin HCl","Nitrendipine","Quinine HCl Dihydrate","Sulfadoxine","Dopamine HCl"]
[null,"f","Empty","S2382","S2399","S2425","S2451","S2460","S2480","S2493","S2503","S2512","S2533","Empty"]
[{"$nulls":3},"Evodiamine","Dihydromyricetin","Apocynin (NSC 2146)","Amantadine HCl","Pramipexole","Loperamide HCl","Olanzapine","Racecadotril","Tenoxicam","Ritodrine HCl"]
[null,"g","Empty","S2383","S2403","S2439","S2452","S2461","S2481","S2494","S2504","S2515","S2535","Empty"]
[{"$nulls":3},"Gastrodin","Tetrandrine (NSC-77037)","Guanosine","Amfebutamone (Bupropion) HCl","Domperidone","Manidipine","Olopatadine HCl","Ribavirin (ICN-1229)","Vardenafil HCl Trihydrate","Econazole nitrate"]
[null,"h","Empty","S2386","S2404","S2442","S2454","S2466","S2482","S2496","S2505","S2519","S2536","Empty"]
[{"$nulls":3},"Indirubin (NSC 105327)","Isoliquiritigenin","Inosine","Bupivacaine HCl","Estriol","Manidipine 2HCl","Ozagrel","Rosiglitazone (BRL-49653) maleate","Naphazoline HCl","Miconazole"]
[]
[]
[]
[null,"Plate layout: L3900-11"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2537","S2556","S2569","S2584","S2599","S2612","S2625","S2635","S2663","S2685","Empty"]
[{"$nulls":3},"Secnidazole","Rosiglitazone (BRL 49653)","Phenylephrine (NCI-C55641) HCl","Clobetasol propionate","L-Thyroxine","Ribitol","Fostamatinib (R788)","CCT128930","WAY-100635 Maleate","KW-2478"]
[null,"b","Empty","S2541","S2557","S2570","S2585","S2601","S2614","S2626","S2637","S2665","S2687","Empty"]
[{"$nulls":3},"Clomipramine HCl","Terbinafine HCl","Prednisolone Acetate","Brompheniramine hydrogen maleate","Gliclazide","Arecoline HBr","Rabusertib (LY2603618)","Fasiglifam(TAK-875) Hemihydrate","Ciprofibrate","Mardepodect (PF-2545920)"]
[null,"c","Empty","S2547","S2559","S2573","S2586","S2602","S2615","S2629","S2639","S2667","S2688","Empty"]
[{"$nulls":3},"Tiotropium Bromide hydrate","Cortisone acetate","Tetracaine HCl","Dimethyl Fumarate","Acemetacin","Noradrenaline bitartrate monohydrate","PNU-120596","SNX-2112 (PF-04928473)","Dolutegravir (GSK1349572)","R547"]
[null,"d","Empty","S2549","S2561","S2574","S2589","S2605","S2617","S2630","S2656","S2672","S2690","Empty"]
[{"$nulls":3},"Trospium chloride","Clomifene citrate","Tetracycline HCl","Miglitol","Idebenone","TAK-733","GW3965 HCl","PF-04929113 (SNX-5422)","PF-00562271 Besylate","ADX-47273"]
[null,"e","Empty","S2551","S2564","S2576","S2590","S2606","S2619","S2631","S2658","S2673","S2691","Empty"]
[{"$nulls":3},"Sulbactam sodium","Cloxacillin Sodium","Xylometazoline HCl","Pioglitazone (AD-4833)","Mifepristone (RU486)","MG132","URB597","Omipalisib (GSK2126458)","Trametinib (GSK1120212)","BMY 7378 Dihydrochloride"]
[null,"f","Empty","S2552","S2565","S2579","S2593","S2608","S2621","S2632","S2660","S2679","S2692","Empty"]
[{"$nulls":3},"Azelastine HCl","Amoxicillin Sodium","Zidovudine","Tolvaptan","Fluocinonide","AZD5438","BMS-378806","MK-0752","Flavopiridol (L86-8275) HCl","TG101209"]
[null,"g","Empty","S2553","S2566","S2581","S2594","S2609","S2623","S2633","S2661","S2680","S2693","Empty"]
[{"$nulls":3},"5-Aminolevulinic acid HCl","Isoprenaline (NCI-C55630) HCl","Quinapril HCl","Pramiracetam","Inulin","Omecamtiv mecarbil (CK-1827452)","NPS-2143","WYE-125132 (WYE-132)","Ibrutinib (PCI-32765)","Resminostat"]
[null,"h","Empty","S2555","S2567","S2583","S2596","S2610","S2624","S2634","S2662","S2683","S2694","Empty"]
[{"$nulls":3},"Clarithromycin","Medroxyprogesterone acetate (NSC-26386)","Thiamphenicol","Clindamycin palmitate HCl","Lonidamine (AF-1890)","OSI-027","Rebastinib (DCC-2036)","Foscenvivint (ICG-001)","CHIR-124","Turofexorate Isopropyl (XL335)"]
[]
[]
[]
[null,"Plate layout: L3900-12"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2695","S2718","S2736","S2749","S2760","S2774","S2789","S2801","S2814","S2842","Empty"]
[{"$nulls":3},"Nepicastat (SYN-117) HCl","TAK-901","Fedratinib (TG101348)","BGT226 (NVP-BGT226) maleate","Canagliflozin (JNJ 28431754)","MK-2461","Tofacitinib (CP-690550)","AZD4547","Alpelisib (BYL719)","SAR131675"]
[null,"b","Empty","S2696","S2719","S2738","S2751","S2762","S2776","S2790","S2803","S2818","S2845","Empty"]
[{"$nulls":3},"Apitolisib (GDC-0980)","AMG-900","PAC-1","Milciclib (PHA-848125)","Alectinib (CH5424802)","Devimistat (CPI-613)","Istradefylline","Galeterone","Tacedinaline (CI994)","Semaxanib (SU5416)"]
[null,"c","Empty","S2698","S2721","S2740","S2752","S2765","S2778","S2791","S2807","S2820","S2849","Empty"]
[{"$nulls":3},"RS-127445","Nilvadipine","GSK1070916","HER2-Inhibitor-1","MK-2048","GW842166X","Sotrastaurin (AEB071)","Dabrafenib (GSK2118436)","TAE226 (NVP-TAE226)","SB269970 HCl"]
[null,"d","Empty","S2699","S2722","S2741","S2753","S2768","S2781","S2792","S2808","S2822","S2851","Empty"]
[{"$nulls":3},"CH5132799","JTC-801","Niraparib (MK-4827)","Tivantinib (ARQ 197)","Dinaciclib (SCH727965)","RITA (NSC 652287)","Torcetrapib","Ipatasertib (GDC-0068)","OC000459","Baricitinib (INCB028050)"]
[null,"e","Empty","S2700","S2726","S2742","S2754","S2769","S2783","S2794","S2809","S2823","S2853","Empty"]
[{"$nulls":3},"Tirbanibulin","PH-797804","PHA-767491 HCl","Xevinapant (AT406)","Dovitinib (TKI-258) Dilactic Acid","Vistusertib (AZD2014)","Sofosbuvir (GS-7977)","MPEP","Tideglusib (NP031112)","Carfilzomib (PR-171)"]
[null,"f","Empty","S2703","S2727","S2743","S2755","S2770","S2784","S2796","S2811","S2828","S2856","Empty"]
[{"$nulls":3},"GSK1838705A","Dacomitinib (PF-00299804)","PF-04691502","Varlitinib","MK-5108 (VX-689)","TAK-285","WP1066","Sapanisertib (MLN0128)","JNJ-1661010","SB 271046 hydrochloride"]
[null,"g","Empty","S2713","S2728","S2747","S2757","S2772","S2785","S2797","S2812","S2830","S2857","Empty"]
[{"$nulls":3},"Geldanamycin (NSC 122750)","AG-1478 (Tyrphostin AG-1478)","AMG-458","Evofosfamide (TH-302)","Dalcetrapib (JTT-705)","A-803467","Lonafarnib (SCH66336)","(R)-(-)-Gossypol acetic acid","Clindamycin","(-)-Dizocilpine (MK 801) Maleate"]
[null,"h","Empty","S2717","S2730","S2748","S2759","S2773","S2787","S2799","S2813","S2840","S2858","Empty"]
[{"$nulls":3},"CP-91149","Crenolanib (CP-868596)","Anacetrapib (MK-0859)","Fimepinostat (CUDC-907)","SB705498","Laquinimod","Daporinad","Ciproxifan Maleate","Apalutamide (ARN-509)","StemRegenin 1 (SR1)"]
[]
[]
[]
[null,"Plate layout: L3900-13"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2859","S2876","S2905","S2925","S3012","S3030","S3043","S3061","S3079","S3120","Empty"]
[{"$nulls":3},"Golvatinib (E7050)","(+)-Dizocilpine (MK 801) Maleate","JNJ-7777120","Evacetrapib (LY2484595)","Pazopanib","Niclosamide (BAY2353)","Rofecoxib","Epinephrine HCl","Atovaquone","Doxepin HCl"]
[null,"b","Empty","S2864","S2884","S2906","S2926","S3015","S3031","S3045","S3062","S3080","S3121","Empty"]
[{"$nulls":3},"IMD 0354","Acesulfame Potassium","Ki16198","TDZD-8","Amoxicillin","Linagliptin (BI-1356)","Cinepazide maleate","Diclofenac Potassium","Etravirine (TMC125)","Ornidazole"]
[null,"c","Empty","S2866","S2890","S2907","S2928","S3017","S3032","S3046","S3063","S3081","S3124","Empty"]
[{"$nulls":3},"U-104","PF-562271","Pirfenidone (S-7701)","TAK-715","Aspirin (NSC 27223)","Bindarit (AF 2838)","Azilsartan","Diclofenac Diethylamine","Ulipristal Acetate (CDB 2914)","Dexamethasone Acetate"]
[null,"d","Empty","S2867","S2894","S2910","S3001","S3019","S3033","S3051","S3066","S3083","S3129","Empty"]
[{"$nulls":3},"WHI-P154","SB742457","Tempol","Clevudine","Ciclopirox ethanolamine","Vildagliptin (LAF-237)","Bosentan Hydrate","Naloxone HCl","Indacaterol Maleate","Trimethoprim"]
[null,"e","Empty","S2868","S2900","S2914","S3002","S3021","S3035","S3052","S3067","S3104","S3130","Empty"]
[{"$nulls":3},"Alogliptin (SYR-322) benzoate","Cobicistat (GS-9350)","Dapivirine (TMC120)","Rivaroxaban (BAY 59-7939)","Rimonabant (SR141716)","Daunorubicin (RP 13057) HCl","Rupatadine Fumarate","Chlorhexidine 2HCl","Moguisteine","Biotin (Vitamin B7)"]
[null,"f","Empty","S2872","S2902","S2918","S3003","S3022","S3036","S3053","S3070","S3105","S3137","Empty"]
[{"$nulls":3},"GW5074","S-Ruxolitinib (INCB018424)","HC-030031","Prostaglandin E2 (PGE2)","Cabazitaxel (XRP6258)","Pravastatin sodium","Azelnidipine","Piracetam","Nadifloxacin","Sodium salicylate"]
[null,"g","Empty","S2874","S2903","S2922","S3005","S3024","S3037","S3054","S3077","S3113","S3140","Empty"]
[{"$nulls":3},"Camostat Mesilate","Lumiracoxib","Icotinib (BPI-2009H)","Paroxetine HCl","Lamotrigine","Bepotastine Besilate","Alverine Citrate","Tazobactam","Pyridoxine HCl","Milnacipran HCl"]
[null,"h","Empty","S2875","S2904","S2924","S3008","S3026","S3038","S3057","S3078","S3117","S3144","Empty"]
[{"$nulls":3},"Prucalopride","PF-477736","Laduviglusib (CHIR-99021) HCl","Zaltoprofen","Piceatannol","Fosaprepitant dimeglumine salt","Azilsartan Medoxomil","Beclomethasone dipropionate","Oxybutynin hydrochloride","Darifenacin HBr"]
[]
[]
[]
[null,"Plate layout: L3900-14"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3147","S3163","S3183","S3212","S3622","S3653","S3668","S3697","S3719","S3729","Empty"]
[{"$nulls":3},"Entacapone","Benztropine mesylate","Amitriptyline HCl","Moclobemide (Ro 111163)","Diammonium Glycyrrhizinate","Spermidine trihydrochloride","Thymopentin","Mafenide hydrochloride","Topiroxostat","Iron sucrose"]
[null,"b","Empty","S3149","S3170","S3189","S3600","S3623","S3654","S3669","S3698","S3720","S3730","Empty"]
[{"$nulls":3},"Estradiol valerate","Ampicillin sodium","Ropinirole HCl","Schisandrin B (Sch B)","Ceftibuten dihydrate","Tauroursodeoxycholic Acid (TUDCA)","Carmustine","Nortriptyline hydrochloride","Elafibranor","Metaxalone"]
[null,"c","Empty","S3150","S3172","S3193","S3603","S3625","S3655","S3674","S3705","S3722","S3732","Empty"]
[{"$nulls":3},"Articaine HCl","Anagrelide HCl","Ticarcillin sodium","Betulinic acid","Tyramine","Cefepime Dihydrochloride Monohydrate","Levamlodipine","Chlorobutanol","Isavuconazole","Avibactam sodium"]
[null,"d","Empty","S3151","S3173","S3199","S3604","S3635","S3656","S3676","S3706","S3723","S3733","Empty"]
[{"$nulls":3},"Gliquidone","Antipyrine","Reboxetine mesylate","Triptolide (PG490)","Medroxyprogesterone","Piribedil","Carbendazim","Sarpogrelate hydrochloride","Ramosetron Hydrochloride","Boceprevir"]
[null,"e","Empty","S3154","S3175","S3200","S3608","S3637","S3657","S3681","S3711","S3724","S3735","Empty"]
[{"$nulls":3},"Butenafine HCl","Atomoxetine HCl","Triflusal","Demethylzeylasteral (T-96)","Cefpirome sulfate","Promestriene","Vitamin E Acetate","Carbasalate Calcium","Velpatasvir","Umeclidinium bromide"]
[null,"f","Empty","S3155","S3176","S3201","S3610","S3639","S3658","S3684","S3713","S3726","S3738","Empty"]
[{"$nulls":3},"Mepivacaine HCl","Betahistine 2HCl","Trifluoperazine 2HCl","Cordycepin","Tacrine hydrochloride hydrate","O6-Benzylguanine","Methacholine chloride","Moxidectin","Selexipag","Travoprost"]
[null,"g","Empty","S3160","S3178","S3207","S3612","S3647","S3659","S3692","S3714","S3727","S3739","Empty"]
[{"$nulls":3},"Ethynodiol diacetate","Brinzolamide","Iopromide","Rosmarinic acid","Mafenide Acetate","Fludrocortisone acetate","N-Ethylmaleimide (NEM)","Lifitegrast","Vilanterol Trifenate","Calcipotriene"]
[null,"h","Empty","S3161","S3180","S3208","S3621","S3648","S3666","S3693","S3716","S3728","S3741","Empty"]
[{"$nulls":3},"Sertaconazole nitrate","Eletriptan HBr","Fexofenadine HCl","Pazufloxacin mesylate","Amlexanox (AA-673)","Ilaprazole","2,6-Dihydroxypurine","Flibanserin","Grazoprevir","Benznidazole"]
[]
[]
[]
[null,"Plate layout: L3900-15"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3742","S3759","S3791","S3826","S3853","S3889","S3941","S3974","S4001","S4014","Empty"]
[{"$nulls":3},"Cholic acid","Norcantharidin","Succinic acid","Hydroxytyrosol","Perillyl alcohol","Arteether","Pinocembrin","(+)-Catechin hydrate","Cabozantinib malate","Hyoscyamine"]
[null,"b","Empty","S3745","S3765","S3796","S3834","S3856","S3897","S3944","S3977","S4002","S4019","Empty"]
[{"$nulls":3},"Balsalazide disodium","Picroside II","Rebaudioside A","Astaxanthin","Allantoin","(-)-Arctigenin","Valproic acid (VPA)","(-)-Borneol","Sitagliptin phosphate monohydrate","Avanafil"]
[null,"c","Empty","S3746","S3772","S3797","S3839","S3860","S3905","S3945","S3980","S4003","S4020","Empty"]
[{"$nulls":3},"Lumefantrine","5-Hydroxymethylfurfural","Helicide","1-Deoxynojirimycin","Allicin","Iso-Steviol","L-Cycloserine","Pyridoxine","Lithocholic acid","Sodium Picosulfate"]
[null,"d","Empty","S3747","S3775","S3804","S3842","S3866","S3922","S3951","S3984","S4004","S4021","Empty"]
[{"$nulls":3},"Levothyroxine sodium","Ligustrazine hydrochloride","Alpha-Mangostin","Isoquercitrin","Galanthamine","(-)-epigallocatechin","Tannic acid","Nordihydroguaiaretic acid (NDGA)","Ethambutol 2HCl","Tolcapone"]
[null,"e","Empty","S3750","S3777","S3805","S3846","S3868","S3925","S3959","S3992","S4007","S4022","Empty"]
[{"$nulls":3},"Sodium benzoate","Gentiopicroside","Stevioside","Eupatilin","Harmine","(-)-Epicatechin gallate","(+)-Borneol","D-(+)-Trehalose dihydrate","Pentamidine isethionate","Probenecid"]
[null,"f","Empty","S3751","S3780","S3811","S3849","S3870","S3931","S3960","S3996","S4009","S4023","Empty"]
[{"$nulls":3},"Quinidine hemisulfate hydrate","Secoisolariciresinol diglucoside","Ginsenoside Re","D-Galactose","D-Pinitol","Ginsenoside Rd","Higenamine hydrochloride","Thioctic acid","Mirabegron","Procaine HCl"]
[null,"g","Empty","S3756","S3787","S3813","S3850","S3872","S3934","S3967","S3998","S4011","S4024","Empty"]
[{"$nulls":3},"Methyl salicylate","Picroside I","Bakuchiol","Glucosamine sulfate","Guaiacol","Acetyl Resveratrol","Flavone","(+)-α-Lipoic acid","Ampiroxicam","Homatropine Methylbromide"]
[null,"h","Empty","S3758","S3788","S3817","S3851","S3876","S3937","S3968","S4000","S4012","S4025","Empty"]
[{"$nulls":3},"Sinomenine hydrochloride","Carvacrol","Harmine hydrochloride","Camphor","Indigo","Pterostilbene","Histamine","Pergolide Mesylate","Desloratadine","Homatropine Bromide"]
[]
[]
[]
[null,"Plate layout: L3900-16"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4026","S4046","S4056","S4071","S4084","S4099","S4113","S4148","S4165","S4184","Empty"]
[{"$nulls":3},"Hydroxyzine 2HCl","Estradiol Cypionate","Retapamulin","Griseofulvin","Lomerizine 2HCl","Dexlansoprazole","Desvenlafaxine","Ampicillin Trihydrate","Benzydamine HCl","Penciclovir"]
[null,"b","Empty","S4031","S4047","S4058","S4076","S4085","S4100","S4116","S4152","S4166","S4185","Empty"]
[{"$nulls":3},"Aclidinium Bromide","Bisacodyl","Ropivacaine HCl","Propranolol HCl","Levobetaxolol HCl","Esmolol HCl","Isovaleramide","Ethamsylate","Chlorpropamide","Tiratricol"]
[null,"c","Empty","S4037","S4048","S4059","S4077","S4086","S4101","S4118","S4155","S4169","S4191","Empty"]
[{"$nulls":3},"Doxapram HCl","Carbimazole","Sodium Nitroprusside Dihydrate","Mequinol","Loxapine Succinate","Voglibose","Histamine 2HCl","Chlorzoxazone","Teriflunomide","Betamipron"]
[null,"d","Empty","S4039","S4049","S4060","S4078","S4089","S4102","S4123","S4159","S4170","S4200","Empty"]
[{"$nulls":3},"Methazolamide","Valdecoxib","Erythromycin Ethylsuccinate","Mefenamic Acid","Halobetasol Propionate","Eprosartan Mesylate","Timolol Maleate","Bezafibrate","Coumarin","Tolperisone HCl"]
[null,"e","Empty","S4040","S4050","S4061","S4079","S4091","S4107","S4125","S4160","S4172","S4202","Empty"]
[{"$nulls":3},"Norethindrone","Valganciclovir HCl","Levobupivacaine HCl","Ticagrelor","Ifenprodil Tartrate","Clofazimine","Sodium Phenylbutyrate","Penicillin G Sodium","Cetylpyridinium Chloride","Verapamil (CP-16533-1) HCl"]
[null,"f","Empty","S4041","S4051","S4064","S4080","S4092","S4110","S4131","S4162","S4176","S4204","Empty"]
[{"$nulls":3},"Olsalazine Sodium","Nabumetone","Escitalopram Oxalate","Triamterene","Pramoxine HCl","Estradiol Benzoate","Levodropropizine","Benzethonium Chloride","Trometamol","Isosorbide"]
[null,"g","Empty","S4042","S4053","S4065","S4081","S4095","S4111","S4143","S4163","S4177","S4206","Empty"]
[{"$nulls":3},"Nafcillin Sodium","Sertraline HCl","Guanabenz Acetate","Sulfacetamide Sodium","Difluprednate","Dicloxacillin Sodium","Pentoxyverine Citrate","Doxycycline Hyclate (WC2031)","Uracil","Cysteamine HCl"]
[null,"h","Empty","S4045","S4054","S4068","S4082","S4096","S4112","S4147","S4164","S4181","S4210","Empty"]
[{"$nulls":3},"Pheniramine Maleate","Spironolactone","Tinidazole","Spiramycin","Droperidol","Desvenlafaxine Succinate hydrate","Azithromycin Dihydrate","Doxofylline","Nicardipine HCl","Benzocaine"]
[]
[]
[]
[null,"Plate layout: L3900-17"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4212","S4225","S4238","S4256","S4267","S4282","S4293","S4309","S4357","S4415","Empty"]
[{"$nulls":3},"Tenatoprazole","Mexiletine HCl","Cepharanthine","Buspirone HCl","Diacerein","Nelfinavir (AG 1343) Mesylate","Promethazine HCl","Bromocriptine Mesylate","Tacrine HCl","Misoprostol"]
[null,"b","Empty","S4213","S4227","S4239","S4258","S4268","S4283","S4294","S4322","S4358","S4420","Empty"]
[{"$nulls":3},"Dirithromycin","Fidaxomicin","Bergapten","Luliconazole","Flufenamic acid","Cyclobenzaprine HCl","Procainamide HCl","Disopyramide Phosphate","Pimozide","Mefloquine HCl"]
[null,"c","Empty","S4214","S4228","S4240","S4259","S4269","S4284","S4295","S4331","S4368","S4502","Empty"]
[{"$nulls":3},"Sucralose","Fluorometholone Acetate","Doxylamine Succinate","Vilazodone HCl","Vinorelbine ditartrate (KW-2307)","Chloroprocaine HCl","Meclofenamate Sodium","Meclocycline Sulfosalicylate","Carbenoxolone Sodium","Eltrombopag"]
[null,"d","Empty","S4217","S4229","S4246","S4260","S4274","S4285","S4296","S4336","S4373","S4504","Empty"]
[{"$nulls":3},"Liothyronine Sodium","Oxybuprocaine HCl","Tranylcypromine (2-PCPA) HCl","Tamibarotene","Rotigotine","Ospemifene","Salmeterol Xinafoate","Metaraminol Bitartrate","Dicyclomine HCl","6-Mercaptopurine (6-MP) Monohydrate"]
[null,"e","Empty","S4221","S4230","S4247","S4261","S4277","S4286","S4297","S4338","S4376","S4505","Empty"]
[{"$nulls":3},"Benzbromarone","Oxaprozin","Prucalopride Succinate","EUK 134","Bambuterol HCl","Anidulafungin (LY303366)","Mupirocin","Methoxamine HCl","Aceclidine HCl","Vinblastine (NSC-49842) sulfate"]
[null,"f","Empty","S4222","S4231","S4248","S4263","S4278","S4289","S4301","S4343","S4377","S4506","Empty"]
[{"$nulls":3},"Piperacillin Sodium","Pilocarpine HCl","Bromfenac Sodium","Efaproxiral Sodium","Carteolol HCl","Metoclopramide HCl","(R)-(+)-Atenolol HCl","Oxethazaine","Imipramine HCl","Acetazolamide"]
[null,"g","Empty","S4223","S4235","S4253","S4265","S4279","S4291","S4303","S4345","S4385","S4507","Empty"]
[{"$nulls":3},"Mevastatin","Phenazopyridine HCl","Epinastine HCl","Nicaraven","Demeclocycline HCl","Labetalol HCl","9-Aminoacridine","Pentoxifylline","Fosfomycin Tromethamine","17-Hydroxyprogesterone"]
[null,"h","Empty","S4224","S4237","S4255","S4266","S4281","S4292","S4307","S4353","S4387","S4514","Empty"]
[{"$nulls":3},"Erythritol","Primaquine Diphosphate","Quinacrine 2HCl","Brimonidine Tartrate","Tasimelteon","Diphenidol HCl","Auranofin","Terfenadine","Bendroflumethiazide","Acetylleucine"]
[]
[]
[]
[null,"Plate layout: L3900-18"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4515","S4536","S4548","S4588","S4601","S4622","S4636","S4650","S4662","S4678","Empty"]
[{"$nulls":3},"Ademetionine disulfate tosylate","Nitrofurantoin","Aminoguanidine hydrochloride","Docusate Sodium","Clioquinol","3,4-Diaminopyridine","Teneligliptin hydrobromide","Atipamezole","Atazanavir","Povidone iodine"]
[null,"b","Empty","S4516","S4538","S4550","S4589","S4603","S4625","S4637","S4651","S4663","S4679","Empty"]
[{"$nulls":3},"(+)-Camphor","Pantoprazole sodium","Azelaic acid","Amodiaquine dihydrochloride dihydrate","Gallic acid","Alcaftadine","Prasugrel Hydrochloride","Etoricoxib","Fusidate Sodium","Terazosin HCl"]
[null,"c","Empty","S4517","S4539","S4552","S4590","S4604","S4626","S4638","S4655","S4664","S4682","Empty"]
[{"$nulls":3},"Cefotaxime sodium","Salicylic acid","Bithionol","Dithranol","Levofloxacin hydrate","Ethosuximide","Desogestrel","Sulpiride","Molsidomine","Loxoprofen"]
[null,"d","Empty","S4521","S4541","S4564","S4593","S4609","S4630","S4640","S4656","S4666","S4683","Empty"]
[{"$nulls":3},"DEET","Triclosan","Diethylcarbamazine citrate","Chlormadinone acetate","Diflunisal","Diazoxide","Lesinurad","Parecoxib","Sivelestat sodium tetrahydrate","Sildenafil Mesylate"]
[null,"e","Empty","S4527","S4542","S4569","S4595","S4610","S4631","S4641","S4657","S4667","S4685","Empty"]
[{"$nulls":3},"Fenofibric acid","Trihexyphenidyl hydrochloride","Fluphenazine dihydrochloride","Cefazolin Sodium","Mebendazole","Prochlorperazine dimaleate salt","Tedizolid Phosphate","Eslicarbazepine Acetate","Lidocaine hydrochloride","Efavirenz"]
[null,"f","Empty","S4528","S4543","S4570","S4596","S4618","S4633","S4646","S4658","S4669","S4686","Empty"]
[{"$nulls":3},"Furazolidone","Trimetazidine dihydrochloride","Halothane","Cefixime","Fenoldopam mesylate","Isosorbide Mononitrate","Ciclesonide","Hydroquinidine","Benzocaine hydrochloride","Vitamin E"]
[null,"g","Empty","S4532","S4544","S4578","S4597","S4619","S4634","S4648","S4660","S4673","S4687","Empty"]
[{"$nulls":3},"Iopamidol","Urethane","Tyloxapol","Lercanidipine hydrochloride","Itopride hydrochloride","Sodium sulfadiazine","Dantrolene sodium hemiheptahydrate","Glycopyrrolate","Etonogestrel","Rivastigmine"]
[null,"h","Empty","S4535","S4547","S4583","S4600","S4620","S4635","S4649","S4661","S4674","S4689","Empty"]
[{"$nulls":3},"Methylene Blue","8-Hydroxyquinoline","Butamben","Benzyl alcohol","Cefuroxime sodium","Cyproheptadine hydrochloride sesquihydrate","Atipamezole hydrochloride","Tiagabine hydrochloride","Hydroxyprogesterone caproate","Deoxycholic acid"]
[]
[]
[]
[null,"Plate layout: L3900-19"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4690","S4708","S4727","S4750","S4797","S4830","S4839","S4851","S4871","S4896","Empty"]
[{"$nulls":3},"Escin","Palmitoylethanolamide","Cinnarizine","Sulfacetamide sodium salt hydrate","Nicergoline","Maltose","Mosapride","Tafluprost","Pyridoxal 5-phosphate monohydrate","Elagolix Sodium"]
[null,"b","Empty","S4693","S4709","S4728","S4751","S4803","S4831","S4844","S4852","S4872","S4908","Empty"]
[{"$nulls":3},"Guanfacine Hydrochloride","Latanoprost","3,3'-Diindolylmethane","Cisapride hydrate","Thymidine (NSC 21548)","Piperonyl butoxide","Cefcapene Pivoxil Hydrochloride","Gadopentetate Dimeglumine","Titanium tetrafluoride","SN-38"]
[null,"c","Empty","S4695","S4711","S4731","S4752","S4812","S4833","S4845","S4853","S4877","S4926","Empty"]
[{"$nulls":3},"D panthenol","Esculetin","Perphenazine","Corticosterone (NSC-9705)","Ceftizoxime","Cefoxitin sodium","Rabeprazole","Ecabet sodium","Eperisone hydrochloride","(R)-Nepicastat HCl"]
[null,"d","Empty","S4696","S4714","S4733","S4760","S4813","S4834","S4846","S4854","S4881","S4927","Empty"]
[{"$nulls":3},"CarbinoxaMine Maleate","(-)-Menthol","Retigabine","(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)","Cefuroxime axetil","Propantheline bromide","Meropenem Trihydrate","Bedaquiline fumarate","Calcium Dobesilate","Cyclen"]
[null,"e","Empty","S4697","S4715","S4734","S4761","S4815","S4835","S4847","S4862","S4883","S4931","Empty"]
[{"$nulls":3},"Saxagliptin hydrate","Benzamide","Retigabine 2HCl","Thymoquinone","L-Cysteine HCl","Aceclofenac","Faropenem Sodium","Squalene","Lynestrenol","Propiverine hydrochloride"]
[null,"f","Empty","S4698","S4719","S4737","S4769","S4816","S4836","S4848","S4865","S4885","S4935","Empty"]
[{"$nulls":3},"Vitamin K1","Kynurenic acid","Psoralen","L-5-Hydroxytryptophan","Diatrizoate sodium","Nilutamide","Dalbavancin","Cefetamet pivoxil hydrochloride","Taurolidine","Asunaprevir (BMS-650032)"]
[null,"g","Empty","S4701","S4723","S4743","S4777","S4817","S4837","S4849","S4867","S4889","S4940","Empty"]
[{"$nulls":3},"2-Deoxy-D-glucose (2-DG)","(-)Epicatechin","Wogonin","Plumbagin","Atenolol","Ibudilast","Levocetirizine Dihydrochloride","Propacetamol hydrochloride","Perospirone hydrochloride","Maltol"]
[null,"h","Empty","S4706","S4725","S4749","S4792","S4819","S4838","S4850","S4869","S4893","S4952","Empty"]
[{"$nulls":3},"Eugenol","Benzenesulfonamide","Citalopram HBr","N-Acetylneuraminic acid","Saccharin","Acotiamide hydrochloride","Flucloxacillin sodium","Sulfamethoxazole sodium","Cytosine","Fumaric acid"]
[]
[]
[]
[null,"Plate layout: L3900-20"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4958","S5002","S5012","S5025","S5052","S5065","S5075","S5106","S5177","S5217","Empty"]
[{"$nulls":3},"Glycocholic acid","Fingolimod (FTY720) HCl","Octenidine Dihydrochloride","Efinaconazole","Granisetron","Ganciclovir sodium","Acotiamide","Lanolin","Naproxen","Arformoterol Tartrate"]
[null,"b","Empty","S4975","S5003","S5013","S5027","S5054","S5066","S5077","S5109","S5179","S5222","Empty"]
[{"$nulls":3},"Fimasartan","Tacrolimus (FK506)","Ioversol","Mebeverine Hydrochloride","Rifamycin sodium salt","Pramipexole dihydrochloride","Regorafenib (BAY-734506) Monohydrate","Ademetionine","Ropivacaine Mesilate","Coluracetam"]
[null,"c","Empty","S4977","S5004","S5014","S5030","S5055","S5067","S5078","S5130","S5200","S5227","Empty"]
[{"$nulls":3},"Efonidipine","Pimecrolimus","Crisaborole (AN2728)","Dihydralazine sulphate","Milbemycin Oxime","Losartan","Osimertinib mesylate","Taurocholic acid sodium salt hydrate","Diaveridine","Erythromycin thiocyanate"]
[null,"d","Empty","S4980","S5005","S5015","S5033","S5058","S5069","S5079","S5145","S5205","S5228","Empty"]
[{"$nulls":3},"Anamorelin","Cefotiam hydrochloride","Simeprevir (TMC435)","Terconazole","Revaprazan Hydrochloride","Dabrafenib Mesylate","Sitagliptin","Protoporphyrin IX","Nilotinib hydrochloride","Minoxidil sulphate"]
[null,"e","Empty","S4994","S5006","S5016","S5034","S5059","S5070","S5082","S5154","S5206","S5229","Empty"]
[{"$nulls":3},"Methylcobalamin","Teprenone","Isoprinosine","Melitracen hydrochloride","Pixantrone Maleate","Mupirocin calcium","Vitamin K2","Tetrahydropiperine","Benzylpenicillin potassium","Isosorbide dinitrate"]
[null,"f","Empty","S4996","S5007","S5019","S5041","S5060","S5071","S5083","S5157","S5208","S5233","Empty"]
[{"$nulls":3},"Tavaborole (AN-2690)","Delamanid","Indobufen","Difloxacin hydrochloride","Metadoxine","Duloxetine","Lentinan","Thymol","Ciprofloxacin hydrochloride hydrate","Fenretinide (NSC 374551)"]
[null,"g","Empty","S4999","S5009","S5020","S5042","S5062","S5073","S5091","S5159","S5211","S5234","Empty"]
[{"$nulls":3},"Avermectin B1","Brivudine","Tilorone dihydrochloride","Bevantolol hydrochloride","Daclatasvir Dihydrochloride","Donepezil","Geranyl acetate","Doxycycline","4-Aminosalicylic acid","Nintedanib Ethanesulfonate Salt"]
[null,"h","Empty","S5001","S5010","S5023","S5049","S5063","S5074","S5100","S5174","S5215","S5238","Empty"]
[{"$nulls":3},"Tofacitinib (CP-690550) Citrate","Indometacin Sodium","Nadolol","Thiocolchicoside","Trelagliptin succinate","Argatroban Monohydrate","Pralidoxime Iodide","Kojic acid","Abacavir (1592U89)","Solifenacin (YM905)"]
[]
[]
[]
[null,"Plate layout: L3900-21"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5239","S5253","S5273","S5295","S5314","S5351","S5372","S5394","S5406","S5426","Empty"]
[{"$nulls":3},"Paroxetine mesylate","Cisapride (R 51619)","Canrenone","Lincomycin Hydrochloride Monohydrate","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","Cefmetazole sodium","Methyl Aminolevulinate Hydrochloride","Tizoxanide","Sultamicillin Tosylate","Bromopyruvic acid"]
[null,"b","Empty","S5240","S5254","S5274","S5297","S5316","S5357","S5373","S5397","S5410","S5430","Empty"]
[{"$nulls":3},"Lenvatinib (E7080) Mesylate","Dasatinib hydrochloride","GS967","Vidarabine monohydrate","NU2058","Safinamide","Pseudolaric Acid B","Chlorhexidine","Chloramphenicol sodium succinate","Metoprolol"]
[null,"c","Empty","S5241","S5255","S5278","S5298","S5319","S5358","S5385","S5398","S5411","S5435","Empty"]
[{"$nulls":3},"Lapatinib ditosylate monohydrate","Nicardipine","Tedizolid (TR-700)","Amoxicillin trihydrate","Imepitoin","Regadenoson","Imidafenacin","Nefazodone hydrochloride","Sultamicillin","Quinacrine Dihydrochloride Dihydrate"]
[null,"d","Empty","S5242","S5257","S5282","S5299","S5321","S5359","S5386","S5399","S5413","S5440","Empty"]
[{"$nulls":3},"Cediranib Maleate","Doxapram","Lactitol monohydrate","Tosufloxacin p-Toluenesulfonate Hydrate","Y15","Butoconazole","7-Dehydrocholesterol","Chlorprothixene hydrochloride","Ertugliflozin","Berberine Sulfate"]
[null,"e","Empty","S5243","S5258","S5284","S5301","S5325","S5363","S5387","S5401","S5414","S5451","Empty"]
[{"$nulls":3},"Ruxolitinib Phosphate","Revefenacin","Adenosine 5'-monophosphate monohydrate","Carglumic Acid","Nitisinone","Pikamilone","D-Tagatose","Tegaserod Maleate","Diflucortolone valerate","Ferulic acid methyl ester"]
[null,"f","Empty","S5245","S5266","S5285","S5307","S5326","S5365","S5388","S5402","S5416","S5458","Empty"]
[{"$nulls":3},"Raltegravir potassium","Stiripentol","RU58841","PSI-6206 (GS-331007)","Dolasetron","Alogliptin","Betrixaban","Dasabuvir (ABT-333)","Metyrapone","Verbascoside"]
[null,"g","Empty","S5246","S5268","S5286","S5311","S5327","S5368","S5389","S5403","S5418","S5473","Empty"]
[{"$nulls":3},"Entecavir","Solithromycin","Ramatroban","Pyridoxal phosphate","Meisoindigo","Lactitol","Betrixaban maleate","Ombitasvir (ABT-267)","Parecoxib Sodium","Pivmecillinam hydrochloride"]
[null,"h","Empty","S5250","S5269","S5293","S5312","S5350","S5371","S5392","S5404","S5420","S5476","Empty"]
[{"$nulls":3},"Darunavir","J147","Nimustine Hydrochloride","Urolithin A","Cefpodoxime proxetil","Ajmaline","Mepivacaine","Paritaprevir (ABT-450)","Clindamycin alcoholate","Rolapitant"]
[]
[]
[]
[null,"Plate layout: L3900-22"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5477","S5487","S5500","S5531","S5552","S5592","S5626","S5652","S5664","S5685","Empty"]
[{"$nulls":3},"Gefarnate","Cefoperazone sodium","Amodiaquine hydrochloride","Doripenem","Amenamevir","Vitamin A","Benzalkonium chloride","Elbasvir","Orphenadrine Hydrochloride","Desoximetasone"]
[null,"b","Empty","S5478","S5488","S5501","S5532","S5561","S5616","S5627","S5653","S5666","S5693","Empty"]
[{"$nulls":3},"Dantrolene sodium","Fluorescein","Hydrocortisone acetate","Erythromycin estolate","Ethacrynic Acid","4-Methylcatechol","Amsacrine hydrochloride","Indigo carmine","Moxisylyte hydrochloride","Levomilnacipran Hydrochloride"]
[null,"c","Empty","S5480","S5490","S5502","S5535","S5563","S5618","S5637","S5654","S5667","S5698","Empty"]
[{"$nulls":3},"Clidinium Bromide","Disopyramide","Ilaprazole sodium","Moxifloxacin","Thioridazine hydrochloride","Hippuric acid","Cefotiam Hexetil Hydrochloride","Indacaterol","Fruquintinib (HMPL-013)","Ketorolac tromethamine salt"]
[null,"d","Empty","S5481","S5491","S5503","S5537","S5566","S5619","S5638","S5655","S5669","S5701","Empty"]
[{"$nulls":3},"Molindone hydrochloride","Lomefloxacin","O-Acetyl-L-carnitine hydrochloride","Tizanidine","Dapagliflozin propanediol monohydrate","Betahistine","Cefozopran hydrochloride","Venlafaxine","Isoxsuprine hydrochloride","Alvimopan dihydrate (LY246736 dihydrate)"]
[null,"e","Empty","S5482","S5492","S5504","S5538","S5568","S5620","S5647","S5657","S5670","S5703","Empty"]
[{"$nulls":3},"Prilocaine hydrochloride","Econazole","Ropivacaine","Tropisetron","Tocofersolan","NSI-189","Emedastine Difumarate","Ertapenem sodium","Chloropyramine hydrochloride","Carvedilol Phosphate"]
[null,"f","Empty","S5484","S5493","S5507","S5539","S5570","S5621","S5648","S5658","S5673","S5709","Empty"]
[{"$nulls":3},"Rimantadine Hydrochloride","Atropine sulfate","Trimebutine maleate","Olprinone","Arachidic acid","Cilastatin","Iguratimod","Omeprazole Sodium","Mivacurium chloride","Norgestrel"]
[null,"g","Empty","S5485","S5494","S5514","S5540","S5581","S5623","S5649","S5659","S5679","S5710","Empty"]
[{"$nulls":3},"Desipramine Hydrochloride","Salbutamol","Lanthanum(III) chloride heptahydrate","Landiolol hydrochloride","Olmesartan","Bedaquiline","Hydroxyzine pamoate","Emedastine","Dolasetron Mesylate","Ambroxol"]
[null,"h","Empty","S5486","S5498","S5527","S5546","S5582","S5625","S5651","S5662","S5683","S5711","Empty"]
[{"$nulls":3},"Fluorometholone","Betahistine mesylate","Salmeterol","Sulfacetamide","Cytarabine hydrochloride","Ammonium lactate","Dexrazoxane","Ranitidine","Isoproterenol sulfate dihydrate","Deracoxib"]
[]
[]
[]
[null,"Plate layout: L3900-23"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5713","S5734","S5752","S5769","S5783","S5805","S5840","S5861","S5903","S5925","Empty"]
[{"$nulls":3},"Pravastatin","Midodrine hydrochloride","Abametapir","Fenoterol","Montelukast","Allopregnanolone","Palifosfamide","Lercanidipine","JANEX-1","Olodaterol hydrochloride"]
[null,"b","Empty","S5714","S5735","S5753","S5771","S5784","S5807","S5842","S5862","S5904","S5926","Empty"]
[{"$nulls":3},"lurasidone","Midodrine","Setipiprant (ACT-129968)","Sulforaphane","Vancomycin","HMN-176","Cabergoline","Metoclopramide","WHI-P97","Pitolisant hydrochloride"]
[null,"c","Empty","S5715","S5737","S5754","S5776","S5787","S5808","S5843","S5863","S5905","S5927","Empty"]
[{"$nulls":3},"Atorvastatin","Diclofenac Epolamine","Baricitinib phosphate","Proflavine","Dronedarone","Relugolix","Cinitapride Hydrogen Tartrate","Metronidazole Benzoate","Suberohydroxamic acid","Proguanil"]
[null,"d","Empty","S5716","S5739","S5761","S5778","S5793","S5811","S5845","S5869","S5909","S5930","Empty"]
[{"$nulls":3},"Abemaciclib (LY2835219)","Nebivolol","Citric acid","Esmolol","Motesanib (AMG-706)","Kevetrin hydrochloride","Chalcone","Cortisone","Anagliptin","PNU 282987 HCl"]
[null,"e","Empty","S5719","S5740","S5763","S5779","S5795","S5812","S5847","S5873","S5911","S5932","Empty"]
[{"$nulls":3},"Ceftizoxime sodium","Palonosetron","D-Mannose","Trimetazidine","Rasagiline","Choline Fenofibrate","Ethacrynate Sodium","Scopolamine HBr trihydrate","Bictegravir","BIA 10-2474"]
[null,"f","Empty","S5720","S5741","S5766","S5780","S5796","S5814","S5848","S5874","S5917","S5935","Empty"]
[{"$nulls":3},"Glecaprevir","Quetiapine","Alfuzosin","Prazosin","Vanoxerine dihydrochloride","cariporide","Frovatriptan Succinate","D-Carnitine hydrochloride","Solcitinib","Alvimopan"]
[null,"g","Empty","S5726","S5742","S5767","S5781","S5803","S5818","S5857","S5887","S5923","S5936","Empty"]
[{"$nulls":3},"Triiodothyronine","Deferoxamine mesylate (Ba 33112)","Aliskiren","Raloxifene","Alrestatin","acalisib (GS-9820)","Trazodone","Khellin","Celiprolol hydrochloride","Cefazolin"]
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[{"$nulls":3},"Delapril Hydrochloride","Chlorpromazine","Fenoterol hydrobromide","Doxazosin","N-Acetylcysteine amide","L-Kynurenine","Vilazodone","Canagliflozin hemihydrate","Olanexidine Hydrochloride semihydrate","Benazepril"]
[]
[]
[]
[null,"Plate layout: L3900-24"]
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[{"$nulls":3},"Bendamustine (SDX105)","VX-702","Terpinen-4-ol","Glycerol Tributyrate","Clemizole","Diroximel Fumarate","Delavirdine mesylate","Lucanthone","R112","GSK2981278"]
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[{"$nulls":3},"Bepotastine","Sodium L-lactate","Arachidonic acid","Glycolic acid","Nimorazole","Lazabemide","Bicyclol","Tinoridine hydrochloride","WHI-P180","Binimetinib (MEK162)"]
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[{"$nulls":3},"Butenafine","Isonicotinic acid","Butylated hydroxytoluene","Octanoic acid","Altiratinib","TAS-301","Docosahexaenoic Acid","Eicosapentaenoic Acid","RG14620","LCL161"]
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[{"$nulls":3},"Amodiaquine","Lactose","Levulinic acid","2-Aminoethanethiol","Apilimod (STA-5326)","Cevimeline HCl hemihydrate","Nifurtimox","uridine triacetate","Briciclib","GDC-0152"]
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[{"$nulls":3},"Fingolimod","β-Caryophyllene","Pentadecanoic acid","Chloramine-T","Azeliragon (TTP488)","Udenafil","Permethrin","fluticasone furoate","CVT-313","Merestinib (LY2801653)"]
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[{"$nulls":3},"Baloxavir marboxil","Doxycycline monohydrate","Ethyl pyruvate","Tulobuterol hydrochloride","PF 429242","Mequitazine","Tafamidis","Doravirine (MK-1439)","MTX-211","Birinapant (TL32711)"]
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[{"$nulls":3},"Disufenton sodium","Oxalacetic acid","Picolinic acid (PCL 016)","Hexetidine","Omilancor (BT-11)","Talniflumate","Fosfluconazole","X-376","ZD-4190","VS-5584 (SB2343)"]
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[{"$nulls":3},"Ataluren (PTC124)","Tridecanoic acid","N-Acetylglucosamine","Zucapsaicin","AGI 1067","Triclocarban","Trandolapril","Mitapivat","AZD2098","Embelin"]
[]
[]
[]
[null,"Plate layout: L3900-25"]
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[{"$nulls":3},"Duvelisib (IPI-145)","Oprozomib (ONX 0912)","GSK923295","(+)-JQ1","KPT-185","Ilomastat","Opaganib (ABC294640)","Losmapimod (GW856553X)","PD173955","Osimertinib (AZD9291)"]
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[{"$nulls":3},"AZD2461","LY2874455","Zotarolimus (ABT-578)","IDO-IN-2","P5091 (P005091)","Abemaciclib mesylate (LY2835219)","Siponimod (BAF312)","Alvelestat (AZD9668)","SC75741","Rilpivirine"]
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[{"$nulls":3},"RG-7112","Tezacaftor (VX-661)","PF-3758309","Zebularine (NSC 309132)","BMS-833923","Glasdegib (PF-04449913)","Molibresib (I-BET-762)","Selinexor (KPT-330)","Edoxaban tosylate Monohydrate","CPI-203"]
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[{"$nulls":3},"XL019","LY2090314","HSP990 (NVP-HSP990)","NU6027","LGK-974","Motolimod (VTX-2337)","PF-04620110","AZD2858","NMS-E973","BAY 87-2243"]
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[{"$nulls":3},"PD168393","Tepotinib (EMD 1214063)","PD123319","AMG-517","BMS-911543","Crenigacestat (LY3039478)","Olverembatinib dimesylate (HQP1351)","Onvansertib (NMS-P937)","Rociletinib (CO-1686)","Itanapraced (CHF 5074)"]
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[{"$nulls":3},"AZD3514","T0901317","Berzosertib (VE-822)","Go6976","AZD1080","Avutometinib","BIO","Beta-Lapachone","TAK-632","Tasisulam"]
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[{"$nulls":3},"CX-6258 HCl","Cilengitide trifluoroacetate","Taselisib (GDC 0032)","Tovorafenib (MLN2480)","Batimastat (BB-94)","Setanaxib (GKT137831)","Idasanutlin (RG-7388)","Vidofludimus","RG2833 (RGFP109)","IOWH032"]
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[{"$nulls":3},"Brefeldin A","Ceritinib (LDK378)","AZD1208","XL888","Marimastat (BB-2516)","Spebrutinib (CC-292)","PF-04418948","AZD1981","Apabetalone (RVX-208)","CW069"]
[]
[]
[]
[null,"Plate layout: L3900-26"]
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[{"$nulls":3},"AZD3965","Aloxistatin (E64d)","FTI 277 HCl","VGX-1027","Decernotinib (VX-509)","Darolutamide (ODM-201)","Filgotinib (GLPG0634)","Cerdulatinib (PRT062070) hydrochloride","MI-773 (SAR405838)","Ruboxistaurin (LY333531) HCl"]
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[{"$nulls":3},"ARQ 621","Calpeptin","GGTI 298 TFA salt","AZD7545","Pritelivir (BAY 57-1293)","AT13148","PX-478 2HCl","Lomitapide","Peficitinib (ASP015K)","Zoligratinib (Debio-1347)"]
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[{"$nulls":3},"PF-562271 HCl","Sorafenib (BAY 43-9006)","Triapine","Darapladib (SB-480848)","THZ1 2HCl","SAR125844","CPI-169","SU9516","SB225002","SU5402"]
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[{"$nulls":3},"Poziotinib (HM781-36B)","Ascomycin (FK520)","EHT 1864 2HCl","Afuresertib (GSK2110183)","Erythromycin Cyclocarbonate","Ledipasvir (GS5885)","Tasquinimod","DTP3","OTS514 hydrochloride","Picropodophyllin (PPP)"]
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[{"$nulls":3},"Birabresib (OTX015)","AR-A014418","MPI-0479605","Entospletinib (GS-9973)","CFI-400945","Anacardic Acid","MI-2 (Menin-MLL Inhibitor)","3PO","PND-1186 (VS-4718)","Omaveloxolone (RTA-408)"]
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[{"$nulls":3},"4EGI-1","Ribociclib (LEE011)","Uprosertib (GSK2141795)","Vactosertib (TEW-7197)","GDC-0623","SB-334867","SD-208","Pilaralisib (XL147)","Telaglenastat (CB-839)","Savolitinib (AZD6094)"]
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[{"$nulls":3},"E-64","APX-3330","(S)-crizotinib","Lorlatinib (PF-6463922)","Domatinostat (4SC-202)","N6022","Niraparib (MK-4827) tosylate","Voxtalisib (XL765)","CPI-360","Sacubitril/valsartan (LCZ696)"]
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[{"$nulls":3},"Pepstatin A","VER-49009","Trelagliptin","SB273005","CL-387785 (EKI-785)","Abscisic Acid (Dormin)","Lomitapide Mesylate","OTS964","Obeticholic Acid","Salirasib"]
[]
[]
[]
[null,"Plate layout: L3900-27"]
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[{"$nulls":3},"ML141","Eprenetapopt (APR-246)","EPZ015666 (GSK3235025)","Emricasan (IDN-6556)","SRT2104 (GSK2245840)","MI-463","BI-847325","Onatasertib (CC 223)","Tiplaxtinin (PAI-039)","ETC-1002"]
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[{"$nulls":3},"PS-1145","BLZ945","KNK437","Coelenterazine","Iadademstat (ORY-1001) 2HCl","Pexidartinib (PLX3397)","Eliglustat","Xanthohumol","STF-31","EPI-001"]
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[{"$nulls":3},"Ceralasertib (AZD6738)","NU1025","Gilteritinib (ASP2215)","Sunitinib (SU11248)","GSK2879552 2HCl","EPZ020411 2HCl","Ulixertinib (BVD-523)","CC-115","Y-39983 HCl","Larotrectinib (LOXO-101) sulfate"]
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[{"$nulls":3},"AZD8186","AZD3839","6-Thio-dG","Dasatinib Monohydrate","Pexmetinib (ARRY-614)","Nazartinib (EGF816)","Brilanestrant (GDC-0810)","Avadomide (CC-122)","Belumosudil (KD025)","TIC10 (ONC201)"]
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[{"$nulls":3},"LY2584702 Tosylate","ISO-1","TRx0237 (LMTX) mesylate","Combretastatin A4","AT7519 HCl","4-Hydroxytamoxifen (Afimoxifene)","Tenofovir Alafenamide (GS-7340)","Sodium Tauroursodeoxycholate (TUDC)","Nemiralisib","PLX8394"]
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[{"$nulls":3},"Verdinexor (KPT-335)","LFM-A13","Dovitinib (TKI258) Lactate monohydrate","Fumagillin","Afatinib (BIBW2992) Dimaleate","Licochalcone A","Oltipraz","Epacadostat (INCB024360)","GSK2292767","AZD8835"]
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[{"$nulls":3},"Monomethyl auristatin E (MMAE)","PRT-060318 2HCl","Cabotegravir (GSK1265744)","Erlotinib (OSI-774)","Itacitinib (INCB39110)","CB1954","NVP-CGM097","Kenpaullone","PX-12","P7C3"]
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[{"$nulls":3},"PRIMA-1","SB239063","Elacridar (GF120918)","Docetaxel Trihydrate","AMG319","Endoxifen HCl","BQ-123","Bromodeoxyuridine (BrdU)","Ozanimod (RPC1063)","Zorifertinib (AZD3759)"]
[]
[]
[]
[null,"Plate layout: L3900-28"]
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[{"$nulls":3},"L755507","Ricolinostat (ACY-1215)","Nirogacestat (PF-03084014)","Apremilast (CC-10004)","Pacritinib (SB1518)","SCH58261","BAY 41-2272","tirabrutinib(ONO-4059) hydrochloride","umbralisib (TGR-1202)","MK-886"]
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[{"$nulls":3},"Favipiravir (T-705)","GSK2636771","Capivasertib (AZD5363)","Zelavespib (PU-H71)","Riviciclib hydrochloride (P276-00)","ZM241385","Resiquimod (R-848)","AMG 337","MK-4101","Ponesimod"]
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[{"$nulls":3},"Napabucasin (BBI608)","PQ 401","GW0742","GDC-0349","Sabutoclax","Acalabrutinib (ACP-196)","Radotinib","Daprodustat (GSK1278863)","Enasidenib (AG-221)","Etomoxir sodium salt"]
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[{"$nulls":3},"FG-2216","SMI-4a","Empagliflozin (BI 10773)","Cobimetinib (GDC-0973)","Vorapaxar (MK-5348)","GMX1778 (CHS828)","Riociguat (BAY 63-2521)","Ro 61-8048","Ivosidenib (AG-120)","CCT245737"]
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[{"$nulls":3},"SKF38393 HCl","AG-18","Tyrphostin AG 1296","Venetoclax (ABT-199)","Bardoxolone Methyl","RHPS 4 methosulfate","Sivelestat (ONO-5046)","Verubecestat (MK-8931) Trifluoroacetate","BAY 1217389","SRT2183"]
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[{"$nulls":3},"Ripasudil (K-115) hydrochloride dihydrate","PRX-08066 Maleic acid","GSK3787","Macitentan (ACT 064992)","C-DIM12","BMS-582949","Halofuginone","Pimavanserin tartrate","Bitopertin","Tomivosertib (eFT-508)"]
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[{"$nulls":3},"Entrectinib (RXDX-101)","Agerafenib (RXDX-105)","Tariquidar (XR9576)","ASP3026","CB-5083","Pamapimod","ON123300","BFH772","NT157","SHP099 HCl"]
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[{"$nulls":3},"SKF96365","Vonoprazan Fumarate (TAK-438)","PRT062607 (P505-15) HCl","Lomeguatrib","Sotagliflozin (LX4211)","MK571","Paxalisib (GDC-0084)","Lanabecestat (AZD3293)","RS-1","MKC-3946"]
[]
[]
[]
[null,"Plate layout: L3900-29"]
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[{"$nulls":3},"VLX1570","Eganelisib (IPI-549)","AZD9496","PF-06273340","TAK-063","Belizatinib (TSR-011)","Asciminib (ABL001)","Amcasertib (BBI503)","Tirofiban Hydrochloride","Linrodostat (BMS-986205)"]
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[{"$nulls":3},"Selonsertib (GS-4997)","PF-06409577","MSC2530818","Naquotinib(ASP8273)","Citarinostat (ACY-241)","A-317491","Tofogliflozin(CSG 452)","Sitravatinib (MGCD516)","S 38093","Ipragliflozin (ASP1941)"]
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[{"$nulls":3},"Olmutinib (BI 1482694)","Miransertib (ARQ 092) HCl","LXR-623 (WAY-252623)","Stenoparib (E7449)","SRT3025 HCl","GSK2256098","Seletalisib (UCB-5857)","PRN1371","NGP 555","Reparixin (Repertaxin)"]
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[{"$nulls":3},"Ossirene","PT2385","Eltanexor (KPT-8602)","Troglitazone (CS-045)","CBL0137 HCl","GDC-0575 (ARRY-575)","IRAK4-IN-2","COTI-2","C188-9","ACY-738"]
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[{"$nulls":3},"SR-12813","Lirametostat (CPI-1205)","Mivebresib (ABBV-075)","NS-398 (NS398)","GSK2982772","Temuterkib (LY3214996)","Verubecestat (MK-8931)","Serabelisib (TAK-117)","Adenosine Dialdehyde (ADOX)","PF-06840003"]
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[{"$nulls":3},"ATI-2341","Tucatinib","Erdafitinib (JNJ-42756493)","KPT 9274 ( ATG-019)","Tanzisertib(CC-930)","Ritlecitinib (PF-06651600)","Omarigliptin (MK-3102)","Repotrectinib (TPX-0005)","Derazantinib(ARQ-087)","Pemrametostat (GSK3326595)"]
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[{"$nulls":3},"MLR-1023","NMS-P118","S49076","BAY-876","PD-166866 (PD166866)","TAS-102","Tucidinostat (Chidamide)","SF2523","Vorasidenib (AG-881)","Elimusertib (BAY-1895344) hydrochloride"]
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[{"$nulls":3},"Samotolisib (LY3023414)","BGP-15 2HCl","RRx-001","UK-371804 HCl","Fisogatinib (BLU-554)","Voxelotor (GBT440)","RXDX-106 (CEP-40783)","Pamiparib (BGB-290)","Sodium dichloroacetate (DCA)","Tenalisib (RP6530)"]
[]
[]
[]
[null,"Plate layout: L3900-30"]
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[{"$nulls":3},"ONC212","MK-8353 (SCH900353)","IACS-010759 (IACS-10759)","INCB054329","Tinostamustine(EDO-S101)","FDL169","BAY-218","Bevirimat","Ammonium Glycyrrhizate","Scopolamine"]
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[{"$nulls":3},"H3B-6527","Nemtabrutinib (ARQ 531)","Verinurad (RDEA3170)","Alofanib (RPT835)","Lanifibranor (IVA-337)","CC-90003","JNJ-38877618(OMO-1)","Berberine","Praeruptorin E","Carboprost"]
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[{"$nulls":3},"Glumetinib (SCC244)","INCB057643","Bimiralisib (PQR309)","AZ304","IDF-11774","Brepocitinib (PF-06700841)","Bentamapimod (AS602801)","Salvianolic acid A","Phellodendrine","Orcinol"]
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[{"$nulls":3},"AS1517499","ABBV-744","Avitinib (AC0010)","S55746","Evobrutinib (M-2951)","Almonertinib (HS-10296)","Letermovir (AIC246)","Anhydroicaritin","Magnoflorine chloride","D-(+)-Trehalose Anhydrous"]
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[{"$nulls":3},"Abequolixron (RGX-104)","Anlotinib (AL3818) dihydrochloride","Naporafenib (LXH254)","Iberdomide (CC220)","AZD3229","GSK3179106","Malic acid","Magnoflorine","Phellodendrine chloride","Oxalic acid"]
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[]
[]
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[{"$nulls":3},"(4S)-4-Hydroxy-L-isoleucine","Demecarium Bromide","Protriptyline hydrochloride","ASP5878","MSX-122","Belotecan (CKD-602) hydrochloride","ITD-1","CC-401 Hydrochloride","Talabostat (PT-100)","Belvarafenib (HM95573)"]
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[{"$nulls":3},"Liensinine","Methenamine Hippurate","Bepridil hydrochloride","PD153035","ABT 702 dihydrochloride","AM 095","YHO-13177","Edonerpic maleate","Navarixin (SCH-527123)","Mavacamten (MYK-461)"]
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[{"$nulls":3},"Urocanic acid","Valbenazine tosylate","Sapropterin Dihydrochloride","Irosustat (BN83495)","Avatrombopag","Radiprodil (RGH-896)","Darovasertib (LXS-196)","SB-756050","zipalertinib","NDI-091143"]
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[{"$nulls":3},"Undecanoic acid","Madecassic acid","AM580","Fosamprenavir calcium salt","Temsavir (BMS-626529)","AZD5069","SR1001","APD668","Unesbulin (PTC596)","Ziritaxestat (GLPG1690)"]
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[{"$nulls":3},"Ethotoin","Brimonidine","Vadadustat","THZ531","E-4031 dihydrochloride","PF-06282999","AX-024 HCl","S1RA","Orludodstat (BAY 2402234)","Taletrectinib (DS-6051b)"]
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[{"$nulls":3},"Benzonatate","Tiapride Hydrochloride","Bohemine","ETC-159","E7820","S107","Besifovir","Pimitespib (TAS-116)","Futibatinib (TAS-120)","Homoharringtonine (CGX-635)"]
[]
[]
[]
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[{"$nulls":3},"BI-1347","Tirapazamine","SIB 1757","Resmetirom (MGL-3196)","G150","GSK-2881078","Licofelone (ML3000)","Seclidemstat (SP-2577)","3'-Fluoro-3'-deoxythymidine (Alovudine)","VLX600"]
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[{"$nulls":3},"Temocapril","IDRA-21","Nicotinamide Riboside Chloride","Sparsentan (PS-433540, RE-021)","Olutasidenib (FT-2102)","Anavex 2-73 HCl","Rubitecan","TP-3654","Ki20227","BAY-1816032"]
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[]
[]
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[{"$nulls":3},"Relebactam","TR-14035","Silmitasertib (CX-4945) sodium salt","Dimethylcurcumin (ASC-J9)","Ningetinib","BAY 1251152","Elraglusib","Acelarin (NUC-1031)","COH-29","JNJ-42165279"]
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[{"$nulls":3},"ABX464","Treprostinil sodium","Isuzinaxib (APX-115 free base)","Gefapixant","SEL201","GSK3145095","IM156","Remibrutinib (LOU064)","Antineoplaston A10","Namodenoson (CF-102)"]
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[{"$nulls":3},"Pemigatinib (INCB054828)","SC-43","Ipragliflozin L-Proline","1-BCP","Preladenant","Mezigdomide (CC-92480)","Donafenib (Sorafenib D3)","BD-1047 dihydrobromide","Emodepside","BNC210"]
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[]
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[{"$nulls":3},"FPL 62064","NP-G2-044","Rapastinel (GLYX-13)","Navoximod","Desidustat","Batefenterol","SCH-442416","Trotabresib","Eliglustat hemitartrate","Maltose monohydrate"]
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[{"$nulls":3},"L-732138","Deoxycholic acid sodium salt","SEA0400","Atamparib (RBN-2397)","Tapinarof","CGP71683 hydrochloride","LY255283","Rhodamine 123","Ledipasvir acetone","Iohexol"]
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[{"$nulls":3},"O-304","N-Acetyl-L-leucine","Dorzagliatin","Fraxin","IACS-13909","Canertinib dihydrochloride","Tecovirimat","Sacubitril hemicalcium salt","Guanabenz","KB-R7943 mesylate"]
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[{"$nulls":3},"Barnidipine","Pyridoxal hydrochloride","Lanreotide","Pentostatin","Muramyl dipeptide","Varenicline (CP 526555) dihydrochloride","Metarrestin (ML246)","Tenofovir alafenamide hemifumarate","Trametinib DMSO solvate","Atropine"]
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[{"$nulls":3},"GSK3117391","Apatinib","APTO-253","NBQX (FG9202)","TK216","BioE-1115","Brequinar Sodium","Ertugliflozin L-pyroglutamic acid","Cetylpyridinium chloride monohydrate","Enasidenib Mesylate"]
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[]
[]
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[{"$nulls":3},"Regorafenib Hydrochloride","Ribociclib succinate","Trometamol hydrochloride","Levocetirizine","Tenofovir Disoproxil","Lusutrombopag","Amcenestrant (SAR439859)","BDTX-189","Remogliflozin etabonate (GSK189075)","KL001"]
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[{"$nulls":3},"Rucaparib","Lesinurad sodium","Pantoprazole sodium hydrate","Efonidipine hydrochloride monoethanolate","Dabigatran etexilate mesylate","Fostemsavir","Inobrodib (CCS-1477)","Elimusertib (BAY-1895344)","Cerdulatinib (PRT062070)","Cilengitide"]
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[{"$nulls":3},"Ceritinib dihydrochloride","Crizotinib hydrochloride","Ceftriaxone Sodium","L-Carnitine hydrochloride","Amlodipine maleate","Pelabresib (CPI-0610)","Vericiguat","Avexitide","BMS-986020","Y-27632"]
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[{"$nulls":3},"Ciprofloxacin hydrochloride","Cinacalcet","Megestrol","Bisoprolol","Pemetrexed","6-Iodopravadoline (AM630)","Lanraplenib (GS-9876)","DDD107498","Olodaterol (BI 1744)","Sephin-1"]
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[{"$nulls":3},"Irinotecan hydrochloride","S-(+)-Ketoprofen","Ipratropium bromide monohydrate","Metoclopramide hydrochloride hydrate","Hydrocortisone hemisuccinate","AMG 487","Farudodstat","Derenofylline (SLV320)","(R)-(-)-Ibuprofen","LY3405105"]
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[{"$nulls":3},"Levobupivacaine","L-Thyroxine sodium salt pentahydrate","Norethindrone acetate","Menadione bisulfite sodium","S(-)-Propranolol hydrochloride","ME-401","PF-00835231","Olodanrigan (EMA401)","Losartan Carboxylic Acid (EXP-3174)","Bavdegalutamide (ARV-110)"]
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[{"$nulls":3},"Perospirone","Furosemide sodium","Bromfenac sodium hydrate","Vardenafil hydrochloride","Eicosapentaenoic acid ethyl ester","Remdesivir (GS-5734)","Indisulam","Eprotirome (KB2115)","H-1152 dihydrochloride","Glycerol phenylbutyrate"]
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[]
[]
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[{"$nulls":3},"Lucitanib (E3810) hydrochloride","Danuglipron (PF-06882961)","2-Hydroxybenzylamine","Pamufetinib (TAS-115)","Vodobatinib (K0706)","Taurocholic acid sodium salt","Taprenepag","NP118809","SQ109","Deudextromethorphan (AVP-786)"]
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[{"$nulls":3},"QX-314 chloride","STM2457","Olesoxime (TRO 19622)","Fadraciclib (CYC065)","Pizuglanstat (TAS-205)","JTE-607 Dihydrochloride","Lotamilast (RVT-501)","NS 1738","Fenoldopam","Riamilovir"]
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[{"$nulls":3},"Inavolisib (GDC-0077)","MYLS22","JNJ-10229570","Azemiglitazone (MSDC-0602)","Seralutinib (GB002)","Sunvozertinib","YL 0919","FK962","Hydroxyflutamide (Hydroxyniphtholide)","Deserpidine"]
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[{"$nulls":3},"AG-636","Danicamtiv (MYK-491)","VX-150","JNJ-67856633","Gemigliptin","Asimadoline hydrochloride","Cycloguanil hydrochloride","Gusacitinib (ASN-002)","Encenicline (EVP-6124) hydrochloride","Zotiraciclib"]
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[{"$nulls":3},"Emavusertib (CA-4948)","Triheptanoin","WS-12","BMS-986299","N-Nitrosodiethylamine","Lu-135252","SD169","SB-200646A","Verubulin hydrochloride","HM43239"]
[]
[]
[]
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[{"$nulls":3},"KA2507","Deferitrin","Zapnometinib (PD0184264)","Metipranolol","Nomegestrol Acetate","Rilpivirine Hydrochloride","Upamostat (WX-671)","Kisspeptin-10 (human)","JNJ-10198409","BAM (8-22)"]
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[{"$nulls":3},"ErSO","Raclopride","JP1302","Prednicarbate","Silydianin","Oritavancin Diphosphate","Aficamten (CK-274)","AZD-9574","T-1101 tosylate","Bremelanotide Acetate"]
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[{"$nulls":3},"MSDC-0602K Potassium","Invert sugar","(R)-Avanafil","Lodenafil","Z944","AST-1306","ODM-207","DMU-212","Doxorubicin","Etelcalcetide HCl"]
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[{"$nulls":3},"Flumatinib (HH-GV-678)","Mometasone Furoate Hydrate","Senicapoc (ICA-17043)","Cedirogant","MID-1","Mitonafide","AFN-1252","Tandospirone","Cridanimod","Epitalon"]
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[{"$nulls":3},"Mericitabine","Rhamnose","Metrizoic acid","Ibiglustat succinate","Timapiprant Sodium","Segesterone acetate","AGX51","Azosemide","Ursodeoxycholic acid sodium","Oglufanide"]
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[{"$nulls":3},"AZD-6280","DPPE fumarate","Norgestimate","Esaxerenone (CS-3150)","CXD101","Rebamipide mofetil","tetrathiomolybdate","SAR407899 hydrochloride","M7583","Angstrom6"]
[]
[]
[]
[null,"Plate layout: L3900-38"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","P1216","S7108","S8587","S0099","S0504","S1217","S2815","S6145","S6897","S7739","Empty"]
[{"$nulls":3},"Box5","Encorafenib (LGX818)","Withaferin A","Asapiprant","SU14813","Cyclophosphamide","Lixivaptan (VPA-985)","PF-05221304","Epertinib hydrochloride","Telacebec (Q203)"]
[null,"b","Empty","P1218","S7817","S8719","S0113","S0733","S1522","S2975","S6549","S6961","S7791","Empty"]
[{"$nulls":3},"Disitertide(P144)","MI-503","AZD4573","Eptapirone","Tegatrabetan (BC-2059)","Tosedostat (CHR2797)","CarboxyaMidotriazole orotate","PBTZ169","Foxy-5","Phorbol 12-myristate 13-acetate (PMA)"]
[null,"c","Empty","P1220","S8162","S8832","S0164","S0803","S1575","S3020","S6594","S6984","S7926","Empty"]
[{"$nulls":3},"tat-nr2b9c","Upadacitinib (ABT-494)","Branebrutinib (BMS-986195)","AZD-7325","Danicopan (ACH-4471)","RO4929097","Romidepsin","Liarozole dihydrochloride","Dianhydrogalactitol (VAL-083)","Lifirafenib (BGB-283)"]
[null,"d","Empty","S1469","S8297","S8833","S0313","S0825","S2211","S3395","S6672","S7023","S7930","Empty"]
[{"$nulls":3},"Calcifediol","ARV-825","TAS0728","Volinanserin","MDR-652","AG-13958","Tegobuvir","PF-05175157","Z-VAD-FMK","Ixabepilone (BMS-247550)"]
[null,"e","Empty","S2841","S8344","S8879","S0338","S0851","S2221","S3494","S6731","S7109","S8055","Empty"]
[{"$nulls":3},"Bemcentinib (R428)","AZD-5153 6-hydroxy-2-naphthoic acid","Deucravacitinib (BMS-986165)","NB 598","G-1","Apatinib (YN968D1) mesylate","Vicriviroc maleate","Eliprodil (SL-820715)","Pevonedistat (MLN4924)","Lersivirine (UK-453061)"]
[null,"f","Empty","S6918","S8381","S8983","S0356","S0861","S2345","S3510","S6757","S7455","S8064","Empty"]
[{"$nulls":3},"Oleandrin (PBI-05204)","BMS-986142","MAK683","Pulrodemstat (CC-90011) besylate","Laninamivir Octanoate","Podophyllotoxin (Podofilox)","NLX-101","NVR 3-778","Resatorvid (TAK-242)","Midostaurin (PKC412)"]
[null,"g","Empty","S7048","S8421","S0014","S0428","S0872","S2653","S4614","S6767","S7554","S8220","Empty"]
[{"$nulls":3},"Talazoparib (BMN 673)","Fenebrutinib (GDC-0853)","HT-2157","Etalocib","ASTX-029","9-amino-CPT (9-Aminocamptothecin)","PNPP","GSK805","Ravoxertinib (GDC-0994)","INCB3344"]
[null,"h","Empty","S7062","S8553","S0037","S0491","S0878","S2733","S5218","S6839","S7736","S8341","Empty"]
[{"$nulls":3},"Pinometostat (EPZ5676)","Avapritinib (BLU-285)","Nidufexor (LMB-763)","Manogepix (E1210)","AT-001","AV-412 free base","Iodixanol","MRX-2843","MLN120B","TAK-243 (MLN7243)"]
[]
[]
[]
[null,"Plate layout: L3900-39"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S8524","S8708","S8834","S8890","S8968","S9676","S9898","E0077","E0616","E1179","Empty"]
[{"$nulls":3},"Edicotinib(JNJ-40346527)","AZD0364 (ATG-017)","GB1107","MK-8719","PRI-724","Ropsacitinib (PF-06826647)","Proxalutamide (GT0918)","Simufilam","Chiauranib","EZM0414"]
[null,"b","Empty","S8531","S8716","S8849","S8925","S8987","S9691","S9901","E0114","E0818","E1180","Empty"]
[{"$nulls":3},"Zimlovisertib (PF-06650833)","Pralsetinib (BLU-667)","TAS4464","Simurosertib","TNO155","BMS-986158","KB-0742 Dihydrochloride","Dilmapimod (SB-681323)","Quinupristin","Sovilnesib"]
[null,"c","Empty","S8532","S8718","S8851","S8926","S8999","S9702","S9944","E0121","E1000","E1183","Empty"]
[{"$nulls":3},"ARV-771","RMC-4550","Elexacaftor (VX-445)","Valemetostat (DS-3201)","Exatecan Mesylate","Finerenone","PRN1008","Parsaclisib (INCB050465)","Zn-C3","MRTX0902"]
[null,"d","Empty","S8535","S8720","S8858","S8939","S9516","S9726","S9970","E0142","E1013","E1184","Empty"]
[{"$nulls":3},"Galicaftor (ABBV-2222)","Imaradenant (AZD4635)","GSK3368715 (EPZ019997) 3HCl","Mizagliflozin (KWA 0711)","SB 265610","Rimiducid (AP1903)","APG-2575 (lisaftoclax)","XL092","Bemnifosbuvir Hemisulfate (AT-527)","CFT7455"]
[null,"e","Empty","S8563","S8722","S8860","S8942","S9522","S9825","S9975","E0164","E1078","E1191","Empty"]
[{"$nulls":3},"TVB-3664","Samuraciclib hydrochloride (ICEC0942 hydrochloride)","Cintirorgon (LYC-55716)","Suramin sodium salt","Valrubicin","Pirtobrutinib (LOXO-305)","ASN007","Antazoline Phosphate","Emvododstat (PTC299)","GDC-1971"]
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[{"$nulls":3},"Elenbecestat","LY3295668","UNBS5162","Sotorasib (AMG510) racemate","Etrumadenant (AB928)","Lufotrelvir (PF-07304814)","BIBO 3304 Trifluoroacetate","Eliapixant","Relacorilant","BAY 2666605"]
[null,"g","Empty","S8636","S8829","S8881","S8958","S9629","S9866","E0041","E0369","E1111","E1208","Empty"]
[{"$nulls":3},"Selitrectinib (LOXO-195)","Subasumstat (TAK-981)","DS-1001b (DS 1001)","Camizestrant (AZD9833)","Elacestrant (RAD1901) Dihydrochloride","Nirmatrelvir (PF-07321332)","Tolebrutinib (SAR442168)","Endovion (NS 3728)","VV116","NPX800"]
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[{"$nulls":3},"Tolinapant (ASTX660)","Sotorasib (AMG510)","Adagrasib (MRTX849)","T-5224","LY3143921 hydrate","LY-3475070","Evatanepag","4SC-203","Ensitrelvir fumarate","CC-99282"]
[]
[]
[]
[null,"Plate layout: L3900-40"]
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[null,"a","Empty","E1239","E2655","E2853","P1151","E4265","E4455","E1328","E1410","E2874","E2902","Empty"]
[{"$nulls":3},"Apararenone","Terevalefim","GSK626616","Difelikefalin","Pyrimidine","Monolaurin","TP-1454","Fluspirilene","Sofpironium bromide","Sodium Pyruvate"]
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[{"$nulls":3},"Pridopidine","R1530","Abarelix Acetate","PMX 205","1,3-BUTANEDIOL","Evocalcet","EG-011","Tuvusertib","Levobunolol(l-Bunolol) hydrochloride","Didox"]
[null,"c","Empty","E2227","E2658","P1032","E4048","E4354","E1056","E1342","E1427","E2876","E2944","Empty"]
[{"$nulls":3},"GLN-1062","FN-1501","CCK Octapeptide (Sincalide)","Phenyl acetate","Phenylethyl isothiocyanate","Opnurasib (JDQ-443)","Sebetralstat","MRT-2359","pemafibrate","Norepinephrine hydrochloride"]
[null,"d","Empty","E2399","E2665","P1069","E4110","E4029","E1214","E1348","E2866","E2878","E2947","Empty"]
[{"$nulls":3},"Falnidamol","Tafenoquine","Ganirelix acetate (Antagon)","Myrcene","Tyramine hydrochloride","KSQ-4279","E-7386","Sodium tetradecyl sulfate","iothalamate sodium","Recilisib"]
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[{"$nulls":3},"NVP-LCQ195","RGB-286638 free base","D-JNKI-1","Menthol","Se-Methylselenocysteine","BGB 15025","AZD1656","Naloxegol Oxalate","methylnaltrexone bromide","Toluidine Blue O"]
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[{"$nulls":3},"Paltusotine","GSK2983559 active metabolite","Linaclotide","(-)-Menthone","Oxypurinol","DPCPX","NX-2127","Trovafloxacin Mesylate","LY3000328","Norepinephrine tartrate"]
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[{"$nulls":3},"Ginsenoside Rg3","Zabedosertib","Antide","(±)-Naringenin","D-chiro-Inositol","Digitonin","BI 1015550","Clocortolone Pivalate","Dxd","Zinc sulfate heptahydrate"]
[null,"h","Empty","E2629","E2843","P1150","E4234","S7830","E1322","E1398","E2873","E2901","E2970","Empty"]
[{"$nulls":3},"Vimseltinib","Poseltinib","Saralasin Acetate","1-Octanol","Coenzyme A","GS-4224","Rilematovir","Laropiprant","(-)-Isoproterenol hydrochloride","Gramicidin"]
[]
[]
[]
[null,"Plate layout: L3900-41"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","E4010","S8908","E1495","E1657","E1775","E4467","S8545","E1445","S4684","Empty","Empty"]
[{"$nulls":3},"L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride","AB680","PF-07220060 (CDK4/6-IN-6)","Gamcemetinib (CC-99677)","2,4-Thiazolidinedione","Temozolomide Acid","TEN-010 (RG6146,Ro-6870810,(S)-JQ-35)","Palovarotene","Sildenafil"]
[null,"b","Empty","E4013","S9633","E1512","E1658","E2363","E4472","S9741","E1477","S7654","Empty","Empty"]
[{"$nulls":3},"Melanin","GS-6207","M3541","PRT543","Etrasimod(APD334)","Clavulanic acid","TAS-119","EP4-IN-1","Defactinib (VS-6063)"]
[null,"c","Empty","E4017","S9865","E1573","E1667","E2668","E4474","S9969","E1483","Empty","Empty","Empty"]
[{"$nulls":3},"Calcium chloride dihydrate","CB-5339","ARV-766","LY2880070","Cirtuvivint","Infigratinib Phosphate","RMC-4630","IK-930"]
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[{"$nulls":3},"BAR502","Fezolinetant","garsorasib (D-1553 )","BAY 2965501","Propiolactone","Lumateperone","Pyrilutamide(KX-826)","Zamaporvint (RXC004)"]
[null,"e","Empty","S1423","E1217","E1596","E1709","E2881","E4478","E1203","E1497","Empty","Empty","Empty"]
[{"$nulls":3},"Dobutamine HCl","PCLX-001 (DDD86481)","AOH1996","Fialuridine","Cefotetan disodium salt","Acetrizoic acid","Sirpiglenastat","Tulmimetostat"]
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[{"$nulls":3},"Filanesib hydrochloride","Lirafugratinib","Lotiglipron","Pimicotinib","Capadenoson","Zandelisib","Ubrogepant","Bezuclastinib"]
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[{"$nulls":3},"Olcegepant","Tinengotinib","Exarafenib","Itacnosertib (TP-0184)","S-Nitrosoglutathione","Cariprazine hydrochloride","Mavorixafor","ZEN-3694"]
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[{"$nulls":3},"CA-170 (AUPM-170)","BDTX-1535","Opevesostat (ODM208)","VX-561(CTP-656, Deutivacaftor)","Saquinavir Mesylate","INDY","LY3537982 (KRAS G12C inhibitor 19)","Pasireotide"]
[]
[]
[]
[null,"Plate layout: L3900-42"]
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[{"$nulls":3},"Perifosine (KRX-0401)","Biapenem","Cidofovir","Tranexamic Acid","Lisinopril dihydrate","Tobramycin","L-NAME HCl","(R)-baclofen","Ceftazidime","Phytic acid"]
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[{"$nulls":3},"Palbociclib (PD-0332991) HCl","Dorzolamide HCl","Ibuprofen Lysine","Levamisole hydrochloride","Fudosteine","NAD+","AMD3465 hexahydrobromide","Caspofungin (MK-0991) Acetate","Penicillin V potassium salt","L-Citrulline"]
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[{"$nulls":3},"Pemetrexed (LY-231514) disodium","Mizoribine","Palbociclib (PD0332991) Isethionate","Ticlopidine HCl","Gabapentin","Lomefloxacin HCl","Zanamivir","Creatinine","Pirenzepine dihydrochloride","L-Theanine"]
[null,"d","Empty","S1149","S1395","S1624","S1985","S2315","S2560","S3013","S3122","S3667","S3973","Empty"]
[{"$nulls":3},"Gemcitabine (LY-188011) HCl","Polymyxin B sulphate","Alendronate sodium trihydrate","ATP disodium","Kanamycin sulfate","Amiloride HCl dihydrate","Plerixafor (AMD3100) 8HCl","Amikacin hydrate","Imipenem","L-SelenoMethionine"]
[null,"e","Empty","S1311","S1399","S1648","S1995","S2416","S2563","S3048","S3148","S3737","S4008","Empty"]
[{"$nulls":3},"Pamidronate Disodium","Teicoplanin","Cytarabine (U-19920A)","Procarbazine HCl","Chondroitin sulfate","Oxacillin sodium monohydrate","Solifenacin succinate","Ibandronate sodium monohydrate","Cangrelor Tetrasodium","Pemirolast potassium"]
[null,"f","Empty","S1338","S1440","S1749","S1998","S2462","S2568","S3050","S3165","S3748","S4013","Empty"]
[{"$nulls":3},"Gabapentin HCl","Varenicline Tartrate (CP 526555-18)","L-Glutamine","D-Cycloserine","Donepezil HCl","Neomycin sulfate","Palonosetron HCl","Abacavir sulfate","Acamprosate Calcium","Sodium Monofluorophosphate"]
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[{"$nulls":3},"Galanthamine HBr","Ralimetinib (LY2228820) dimesylate","Gadodiamide Hydrate","Sodium butyrate","Neostigmine Bromide","Streptomycin sulfate","Miltefosine","L-Arginine HCl (L-Arg)","isoleucine","Flavoxate HCl"]
[null,"h","Empty","S1345","S1506","S1853","S2048","S2507","S2575","S3065","S3211","S3753","S4028","Empty"]
[{"$nulls":3},"Granisetron HCl","Perindopril Erbumine","Penicillamine","Clindamycin Phosphate","Salbutamol Sulfate","Vancomycin HCl","Amikacin disulfate","Thiamine HCl (Vitamin B1)","L-Leucine","Dexamethasone Sodium Phosphate"]
[]
[]
[]
[null,"Plate layout: L3900-43"]
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[{"$nulls":3},"Colistin Sulfate","Mildronate","Proflavine Hemisulfate","Sisomicin sulfate","Creatine phosphate disodium salt","L-carnosine","Ectoine","Aminomalonic acid","Rilmenidine Phosphate","Bivalirudin Trifluoroacetate"]
[null,"b","Empty","S4030","S4146","S4254","S4567","S4827","S5252","S5631","S6176","S7785","P1011","Empty"]
[{"$nulls":3},"Gentamicin Sulfate","Bacitracin","Apramycin Sulfate","Eprodisate disodium","Manganese chloride","Ozagrel sodium","L-Alanine","Scyllo-Inositol","Pemetrexed Disodium Hydrate","Eptifibatide Acetate"]
[null,"c","Empty","S4052","S4157","S4271","S4575","S4972","S5296","S5634","S6460","S8199","P1017","Empty"]
[{"$nulls":3},"Netilmicin Sulfate","Chloroquine diphosphate","Isepamicin Sulphate","Pralidoxime chloride","Choline Glycerophosphate","Cephradine monohydrate","L-arginine","Sugammadex (sodium)","Ruxotemitide (LTX 315)","Octreotide (SMS 201-995) acetate"]
[null,"d","Empty","S4093","S4158","S4287","S4582","S5048","S5384","S5635","S6488","S8442","P1025","Empty"]
[{"$nulls":3},"Bismuth Subcitrate Potassium","Ceftriaxone disodium salt hemi (heptahydrate)","Micafungin (FK 463) Sodium","Eflornithine (MDL-71782) hydrochloride hydrate","Fosfomycin Disodium","UTP Trisodium Salt","L-cysteine","Gadoxetate sodium","TAK-659","Atosiban Acetate"]
[null,"e","Empty","S4108","S4174","S4298","S4606","S5097","S5412","S5660","S6592","S8454","P1029","Empty"]
[{"$nulls":3},"Clodronate Disodium","Sodium Gluconate","Amifostine trihydrate","Glutathione","Methotrexate disodium","Loxoprofen Sodium","Clodronate disodium tetrahydrate","Diquafosol Tetrasodium","ATN-161 (Ac-PHSCN-NH2)","Oxytocin (Syntocinon)"]
[null,"f","Empty","S4117","S4180","S4314","S4653","S5131","S5524","S5721","S7204","S8501","P1030","Empty"]
[{"$nulls":3},"Histamine Phosphate","Nefopam HCl","Ceftazidime Pentahydrate","L-Ornithine hydrochloride","Homotaurine","Spermine Tetrahydrochloride","Edetate calcium disodium","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","Adaptavir (DAPTA)","Salmon Calcitonin Acetate"]
[null,"g","Empty","S4121","S4183","S4392","S4671","S5136","S5533","S5801","S7537","S8549","P1034","Empty"]
[{"$nulls":3},"Succinylcholine Chloride Dihydrate","Paromomycin Sulfate","Potassium Canrenoate","Cefradine","Calcium folinate","Tobramycin sulfate","Ala-Gln","LB-100","AUNP-12","Terlipressin Acetate"]
[null,"h","Empty","S4127","S4234","S4430","S4702","S5220","S5588","S6023","S7547","S9367","P1039","Empty"]
[{"$nulls":3},"Terbutaline Sulfate","Capreomycin Sulfate","Hydroxychloroquine Sulfate (NSC 4375)","Sarcosine","D-Pantethine","Creatine","Creatine monohydrate","XL413 (BMS-863233)","Adenosine disodium triphosphate hydrate","Somatostatin Acetate"]
[]
[]
[]
[null,"Plate layout: L3900-44"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","P1049","S2433","S8414","S5260","S6289","S3736","S6482","E2895","Empty","Empty","Empty"]
[{"$nulls":3},"GHRP-2","DL-Buthionine-Sulfoximine","PACAP 1-27","ATP","Gentamicin","Fondaparinux Sodium (Org 31540)","Fosphenytoin (disodium)","Sodium Bicarbonate"]
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[{"$nulls":3},"Desmopressin Acetate","Sodium stibogluconate","PACAP 1-38","Amikacin Sulfate Salt","Merbromin","PACAP 6-38","Prednisolone disodium phosphate","Potassium Chloride"]
[null,"c","Empty","P1085","S8670","P1201","S5964","E0510","S8505","E0178","S2542","Empty","Empty","Empty"]
[{"$nulls":3},"Angiotensin II human Acetate","Vipivotide tetraxetan (PSMA-617)","LL37 (Human cathelicidin)","Gatifloxacin hydrochloride","Cidofovir hydrate","LY2510924","Cysteamine bitartrate","Phenformin (NSC-756501) HCl"]
[null,"d","Empty","P1087","S4933","S1314","S9803","E0525","S9725","P1148","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Carperitide Acetate","Lithium carbonate","Zoledronic acid (ZOL 446)","Elamipretide (MTP-131)","Colistin","Balixafortide (POL6326)","BPC157"]
[null,"e","Empty","S1671","S9665","S3497","S2967","E0532","E1223","E4258","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"(6-)ε-​Aminocaproic acid","Motixafortide (BL-8040)","Gadobutrol","XE991 dihydrochloride","Menotropin","RGX-202","L-Norleucine"]
[null,"f","Empty","S3076","P1088","S4494","S7920","E2635","E2035","E4111","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Foscarnet Sodium","Lanreotide acetate","Methionine","L-NMMA acetate","Bicinchoninic acid disodium salt","Larazotide","Phytic acid (dodecasodium salt hydrate)"]
[null,"g","Empty","S5865","S3327","S4879","S9489","E2830","P1019","E2759","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Hyaluronic acid","Disodium 5'-inosinate monohydrate","Tenofovir hydrate","Sodium citrate","Cyclocreatine","Cetrorelix Acetate","L-(+)-Ergothioneine"]
[null,"h","Empty","S3948","S3346","S5022","S9820","P1137","P1027","E4018","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Spermine","1-Methylnicotinamide chloride","Varenicline Hydrochloride","Angiotensin (1-7)","Thymulin","Melanotan II","Ammonium sulfate"]
[]
[]
[]
[null,"Plate layout: L3900-45"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1019","S1288","S1519","S1977","S2206","S2684","S3891","S5116","S6642","S7698","Empty"]
[{"$nulls":3},"Canertinib (CI-1033)","Camptothecin (NSC-100880)","CCT129202","Sarafloxacin HCl","Fostamatinib (R788) disodium","Pidnarulex (CX-5461)","Vincamine","Bilibubin","Branaplam (LMI070)","LY2584702"]
[null,"b","Empty","S1023","S1327","S1615","S1986","S2232","S2735","S4126","S5232","S6719","S7756","Empty"]
[{"$nulls":3},"Erlotinib (OSI-774) HCl","Ellagic acid","Risperidone","Meclizine 2HCl","Ketanserin","MK-8776 (SCH 900776)","Retinyl (Vitamin A) Palmitate","Alectinib (CH5424802) hydrochloride","E6446 dihydrochloride","Indoximod (NLG-8189）"]
[null,"c","Empty","S1043","S1353","S1642","S2035","S2251","S2788","S4218","S5499","S7004","S7819","Empty"]
[{"$nulls":3},"Tandutinib (MLN518)","Ketoconazole (R 41400)","Methyldopa","Epalrestat (ONO-2235)","(-)-Huperzine A (HupA)","Capmatinib (INCB28060)","Amoxapine","Amantadine","EPZ005687","BLU9931"]
[null,"d","Empty","S1046","S1360","S1698","S2047","S2292","S2920","S4262","S5601","S7035","S7842","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)","GSK1059615","Torsemide","Lornoxicam","Diosmin","Mozavaptan","Ebastine","Balofloxacin Dihydrate","XL388","LY3009120"]
[null,"e","Empty","S1108","S1371","S1707","S2110","S2476","S3041","S4605","S5712","S7061","S7846","Empty"]
[{"$nulls":3},"TAE684 (NVP-TAE684)","Cefoselis Sulfate","Eplerenone (CGP 30083)","Vinpocetine","Itraconazole (R 51211)","Droxidopa","Folic acid","Zofenopril calcium","GSK126","Dubermatinib(TP-0903)"]
[null,"f","Empty","S1112","S1424","S1724","S2150","S2582","S3064","S4642","S5908","S7128","S8012","Empty"]
[{"$nulls":3},"SGX-523","Prazosin HCl","Paliperidone","Neratinib (HKI-272)","Trazodone HCl","Ambroxol HCl","Dolutegravir Sodium","Garenoxacin","Tazemetostat (EPZ-6438)","Otenabant (CP-945598) HCl"]
[null,"g","Empty","S1205","S1507","S1851","S2152","S2597","S3636","S4654","S6001","S7221","S8138","Empty"]
[{"$nulls":3},"PIK-75 HCl","Irbesartan","Oxibendazole","Sitafloxacin Hydrate","Oseltamivir Phosphate","Cefadroxil hydrate","Netupitant","pomaglumetad (LY404039)","Vesatolimod (GS-9620)","Molidustat (BAY 85-3934)"]
[null,"h","Empty","S1211","S1509","S1929","S2157","S2628","S3721","S4930","S6632","S7518","S8229","Empty"]
[{"$nulls":3},"Imiquimod (R-837)","Norfloxacin","Irsogladine","Taladegib (LY2940680)","Gedatolisib (PKI-587)","Bilastine","Cetilistat","Mirogabalin (DS-5565)","Voreloxin (SNS-595) hydrochloride","Brigatinib (AP26113)"]
[]
[]
[]
[null,"Plate layout: L3900-46"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S8548","S6949","S9464","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Roblitinib (FGF401)","OTX008","Tranylcypromine Sulfate"]
[null,"b","Empty","S8568","S4482","S9826","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"G1T38","Palbociclib","TPX-0046"]
[null,"c","Empty","S8724","E0524","S9872","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Lazertinib","Spinosad","AG-270"]
[null,"d","Empty","S5098","S3309","E4468","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Gefitinib hydrochloride","Solasodine","Cabotegravir Sodium"]
[null,"e","Empty","S8927","S7178","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"GSK2983559 (compound 3)","Prexasertib HCl (LY2606368)"]
[null,"f","Empty","S1502","S3570","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Cephalexin","ARRY-382"]
[null,"g","Empty","S8875","S6385","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"MKC8866","Prexasertib (LY2606368)"]
[null,"h","Empty","S0063","S7089","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"RG3039","SM-164"]
[]
[]
[]
[null,"Plate layout: L3900-47"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1346","S4067","S2050","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Heparin sodium","Deferiprone","Strontium Ranelate"]
[null,"b","Empty","S1428","S4226","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Risedronate Sodium","Minocycline (CL 59806) HCl"]
[null,"c","Empty","S1911","S4694","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Disodium Cromoglycate","Alosetron Hydrochloride"]
[null,"d","Empty","S1982","S5355","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Adenine sulfate","Piperaquine phosphate"]
[null,"e","Empty","S2106","S5695","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Azasetron HCl","Icatibant Acetate"]
[null,"f","Empty","S2562","S8030","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Hydralazine HCl","Plerixafor (AMD3100)"]
[null,"g","Empty","S3055","S5650","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Besifloxacin HCl","Sodium Hyaluronate"]
[null,"h","Empty","S3749","S2095","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Calcium gluconate monohydrate","Fosinopril Sodium"]
[]
[]
[]
[null,"Plate layout: L3900-48"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4444","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Hypromellose"]
[null,"b","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L3900-Clinical-3603 cpds","index":1,"n_rows":3604,"n_cols":23,"rows_kept":3604}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1002","ABT-737","a2","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Mitophagy","Apoptosis","ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.",813.43,"852808-04-9",{"v":100,"d":"100.00"},122.94,"<1","N/A","http://selleckchem.com/products/ABT-737.html","C42H45ClN6O5S2","free base","N/A","CN(C)CCC(CSC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[S](=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=C(C=CC=C5)C6=CC=C(Cl)C=C6",8.198,3,2,16]
["S1003","Linifanib (ABT-869)","b2","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,CSF-1R,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.",375.41,"796967-16-3",{"v":75,"d":"75.00"},199.78,"<1","N/A","http://selleckchem.com/products/ABT-869.html","C21H18FN5O","free base","AL39324,RG3635","CC1=CC(=C(F)C=C1)NC(=O)NC2=CC=C(C=C2)C3=C4C(=N[NH]C4=CC=C3)N",4.169,2,4,3]
["S1004","Veliparib (ABT-888)","c2","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,PARP","DNA Damage/DNA Repair","Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.",244.29,"912444-00-9",{"v":17,"d":"17.00"},69.59,"<1","N/A","http://selleckchem.com/products/ABT-888.html","C13H16N4O","free base","NSC 737664","CC1(CCCN1)C2=NC3=C(C=CC=C3[NH]2)C(N)=O",0.986,2,3,2]
["S1005","Axitinib (AG 013736)","d2","L3900-01","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.",386.47,"319460-85-0",{"v":35,"d":"35.00"},90.56,"<1","N/A","http://selleckchem.com/products/Axitinib.html","C22H18N4OS","free base","AG 013736","CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=N[NH]3)\\C=C\\C4=CC=CC=N4",4.492,3,2,5]
["S1006","Saracatinib (AZD0530)","e2","L3900-01","in 10mM DMSO","Autophagy,EGFR,Src","Angiogenesis","Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.",542.03,"379231-04-6",{"v":35,"d":"35.00"},64.57,"<1","N/A","http://selleckchem.com/products/AZD0530.html","C27H32ClN5O5","free base","N/A","CN1CCN(CCOC2=CC(=C3C(=NC=NC3=C2)NC4=C(Cl)C=CC5=C4OCO5)OC6CCOCC6)CC1",3.814,7,1,8]
["S1007","Roxadustat (FG-4592)","f2","L3900-01","in 10mM DMSO","Ferroptosis,HIF","Angiogenesis","Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.",352.34,"808118-40-3",{"v":70,"d":"70.00"},198.67,"<1","N/A","http://selleckchem.com/products/fg-4592.html","C19H16N2O5","free base","ASP1517","CC1=NC(=C(O)C2=C1C=C(OC3=CC=CC=C3)C=C2)C(=O)NCC(O)=O",2.306,4,2,5]
["S1008","Selumetinib (AZD6244)","g2","L3900-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","Selumetinib (AZD6244, ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2. It  also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Selumetinib suppresses cell proliferation, migration and trigger apoptosis. Phase 3.",457.68,"606143-52-6",{"v":91,"d":"91.00"},198.83,"<1","N/A","http://selleckchem.com/products/AZD6244.html","C17H15BrClFN4O3","free base","ARRY-142886","C[N]1C=NC2=C(F)C(=C(C=C12)C(=O)NOCCO)NC3=CC=C(Br)C=C3Cl",3.234,3,3,6]
["S1010","Nintedanib (BIBF 1120)","h2","L3900-01","in 10mM DMSO","FGFR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","Nintedanib (BIBF 1120, Intedanib, Vargatef, Ofev) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM in cell-free assays. Phase 3.",539.62,"656247-17-5",{"v":6,"d":"6.00"},11.12,"<1","N/A","http://selleckchem.com/products/BIBF1120.html","C31H33N5O4","free base","Intedanib, Vargatef, Ofev","COC(=O)C1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(C)CC4)/C5=CC=CC=C5",2.965,4,2,8]
["S1011","Afatinib (BIBW2992)","a3","L3900-01","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.",485.94,"850140-72-6",{"v":97,"d":"97.00"},199.61,"<1","N/A","http://selleckchem.com/products/BIBW2992.html","C24H25ClFN5O3","Free Base","BIBW2992","CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC=C(F)C(=C3)Cl)N=CN=C2C=C1OC4CCOC4",3.917,5,2,8]
["S1012","BMS-536924","b3","L3900-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","BMS-536924 (CS-0117) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.",479.96,"468740-43-4",{"v":96,"d":"96.00"},200.02,"<1","N/A","http://selleckchem.com/products/BMS-536924.html","C25H26ClN5O3","free base","CS-0117","CC1=C2N=C([NH]C2=CC(=C1)N3CCOCC3)C4=C(NCC(O)C5=CC=CC(=C5)Cl)C=CNC4=O",2.385,3,4,6]
["S1013","Bortezomib (PS-341)","c3","L3900-01","in 10mM DMSO","Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome","Proteases","Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.",384.24,"179324-69-7",{"v":76,"d":"76.00"},197.79,"<1","N/A","http://selleckchem.com/products/Bortezomib.html","C19H25BN4O4","Free Base","Velcade, LDP-341, MLM341, NSC 681239,PS-341","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O",2.183,4,2,9]
["S1014","Bosutinib (SKI-606)","d3","L3900-01","in 10mM DMSO","Autophagy,Bcr-Abl,ERK,S6 Kinase,Src,STAT","Angiogenesis","Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.",530.45,"380843-75-4",{"v":100,"d":"100.00"},188.52,"<1","N/A","http://selleckchem.com/products/Bosutinib.html","C26H29Cl2N5O3","free base","SKI-606","COC1=C(Cl)C=C(Cl)C(=C1)NC2=C(C=NC3=CC(=C(OC)C=C23)OCCCN4CCN(C)CC4)C#N",4.883,4,1,9]
["S1017","Cediranib (AZD2171)","e3","L3900-01","in 10mM DMSO","Autophagy,c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.",450.51,"288383-20-0",{"v":90,"d":"90.00"},199.77,"<1","N/A","http://selleckchem.com/products/Cediranib.html","C25H27FN4O3","free base","NSC-732208","COC1=C(OCCCN2CCCC2)C=C3N=CN=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.761,5,1,8]
["S1018","Dovitinib (TKI-258)","f3","L3900-01","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.",392.43,"405169-16-6",{"v":30,"d":"30.00"},76.45,"<1","N/A","http://selleckchem.com/products/CHIR-258.html","C21H21FN6O","Citrate","CHIR-258","CN1CCN(CC1)C2=CC3=C(C=C2)N=C([NH]3)C4=C(N)C5=C(NC4=O)C=CC=C5F",1.781,2,3,2]
["S1020","PD184352 (CI-1040)","g3","L3900-01","in 10mM DMSO","Apoptosis related,MEK","MAPK","PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. PD184352 (CI-1040) selectively induces apoptosis.",478.67,"212631-79-3",{"v":96,"d":"96.00"},200.56,"<1","N/A","http://selleckchem.com/products/CI-1040-(PD184352).html","C17H14ClF2IN2O2","free base","N/A","FC1=CC=C(C(=O)NOCC2CC2)C(=C1F)NC3=CC=C(I)C=C3Cl",4.907,2,2,6]
["S1021","Dasatinib (BMS-354825)","h3","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.",488.01,"302962-49-8",{"v":98,"d":"98.00"},200.82,"<1","N/A","http://selleckchem.com/products/Dasatinib.html","C22H26ClN7O2S","free base","BMS-354825","CC1=NC(=CC(=N1)N2CCN(CCO)CC2)NC3=NC=C(S3)C(=O)NC4=C(Cl)C=CC=C4C",3.439,4,3,7]
["S1022","Ridaforolimus (Deforolimus, MK-8669)","a4","L3900-01","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.",990.21,"572924-54-0",{"v":198,"d":"198.00"},199.96,"<1","N/A","http://selleckchem.com/products/Deforolimus.html","C53H84NO14P","free base","AP23573","COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.303,12,1,8]
["S1025","Gefitinib (ZD1839)","b4","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,EGFR","Protein Tyrosine Kinase","Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.",{"v":446.9,"d":"446.90"},"184475-35-2",{"v":89,"d":"89.00"},199.15,"<1","N/A","http://selleckchem.com/products/Gefitinib.html","C22H24ClFN4O3","free base","Iressa,ZD1839","COC1=C(OCCCN2CCOCC2)C=C3C(=NC=NC3=C1)NC4=CC=C(F)C(=C4)Cl",4.203,5,1,8]
["S1026","Imatinib (STI571) Mesylate","c4","L3900-01","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.",589.71,"220127-57-1",{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Imatinib-Mesylate.html","C29H31N7O.CH4SO3","Mesylate","Gleevec, Glivec, CGP-57148B,STI571","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5.C[S](O)(=O)=O",3.806,4,2,7]
["S1028","Lapatinib (GW-572016) Ditosylate","d4","L3900-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.",925.46,"388082-77-7",{"v":100,"d":"100.00"},108.05,"<1","N/A","http://selleckchem.com/products/Lapatinib-Ditosylate.html","C29H26ClFN4O4S.2C7H8O3S","Ditosylat","GW-572016","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(=C7)F)C(=C6)Cl)C5=C4",9.339,6,2,13]
["S1029","Lenalidomide (CC-5013)","e4","L3900-01","in 10mM DMSO","Apoptosis related,Caspase,E3 Ligase ,E3 ligase Ligand,TNF-alpha,VEGFR","Ubiquitin","Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.",259.26,"191732-72-6",{"v":52,"d":"52.00"},200.57,"<1","N/A","https://www.selleckchem.com/products/lenalidomide-s1029.html","C13H13N3O3","free base","CC-5013","NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",-0.515,3,2,1]
["S1030","Panobinostat (LBH589)","f4","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC,HIV Protease","Epigenetics","Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.",349.43,"404950-80-7",{"v":69,"d":"69.00"},197.46,"<1","N/A","http://selleckchem.com/products/LBH-589.html","C21H23N3O2","Free Base","NVP-LBH589","CC1=C(CCNCC2=CC=C(\\C=C\\C(=O)NO)C=C2)C3=C([NH]1)C=CC=C3",3.194,1,3,7]
["S1032","Motesanib Diphosphate (AMG-706)","g4","L3900-01","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3.",569.44,"857876-30-3",{"v":100,"d":"100.00"},175.61,{"v":19,"d":"19.00"},33.37,"http://selleckchem.com/products/Motesanib-Diphosphate.html","C22H23N5O.2H3PO4","Diphosphate","N/A","CC1(C)CNC2=CC(=CC=C12)NC(=O)C3=C(NCC4=CC=NC=C4)N=CC=C3.O[P](O)(O)=O.O[P](O)(O)=O",1.783,3,3,5]
["S1033","Nilotinib (AMN-107)","h4","L3900-01","in 10mM DMSO","AMPK,Autophagy,Bcr-Abl","Angiogenesis","Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.",529.52,"641571-10-0",{"v":27,"d":"27.00"},50.99,"<1","N/A","http://selleckchem.com/products/Nilotinib.html","C28H22F3N7O","free base","AMN-107","CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CC=C5",5.084,5,2,7]
["S1035","Pazopanib HCl (GW786034 HCl)","a5","L3900-01","in 10mM DMSO","Autophagy,c-Kit,CSF-1R,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.",473.98,"635702-64-6",{"v":17,"d":"17.00"},35.87,"<1","N/A","http://selleckchem.com/products/Pazopanib-Hydrochloride.html","C21H23N7O2S.HCl","Hydrochloride","GW786034 HCl","Cl.C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",4.123,5,2,5]
["S1036","Mirdametinib (PD0325901)","b5","L3900-01","in 10mM DMSO","MEK","MAPK","Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.",482.19,"391210-10-9",{"v":96,"d":"96.00"},199.09,"<1","N/A","http://selleckchem.com/products/PD-0325901.html","C16H14F3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C=C1)F",2.578,2,4,7]
["S1038","PI-103","c5","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.",348.36,"371935-74-9",{"v":24,"d":"24.00"},68.89,"<1","N/A","http://selleckchem.com/products/PI-103.html","C19H16N4O3","free base","N/A","OC1=CC(=CC=C1)C2=NC3=C(OC4=C3C=CC=N4)C(=N2)N5CCOCC5",2.798,5,1,2]
["S1039","Rapamycin (AY-22989)","d5","L3900-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1","N/A","http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1040","Sorafenib (BAY 43-9006) tosylate","e5","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate)  is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",637.03,"475207-59-1",{"v":127,"d":"127.00"},199.36,0.01,0.02,"http://selleckchem.com/products/Sorafenib-Tosylate.html","C21H16ClF3N4O3.C7H8O3S","Tosylate","BAY 43-9006 tosylate,NSC-724772 tosylate","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O",5.824,4,3,7]
["S1041","STF-62247","f5","L3900-01","in 10mM DMSO","Autophagy","Autophagy","STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).",267.35,"315702-99-9",{"v":53,"d":"53.00"},198.24,"<1","N/A","http://selleckchem.com/products/STF-62247.html","C15H13N3S","free base","N/A","CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3",3.659,2,1,3]
["S1042","Sunitinib (SU11248) malate","g5","L3900-01","in 10mM DMSO","Apoptosis related,c-Kit,IRE1,Mitophagy,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.",532.56,"341031-54-7",{"v":15,"d":"15.00"},28.17,"<1","N/A","http://selleckchem.com/products/Sunitinib-Malate-(Sutent).html","C22H27FN4O2.C4H6O5","Malate","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=CC=C(F)C=C23.OC(CC(O)=O)C(O)=O",-1.049,4,4,10]
["S1044","Temsirolimus (CCI-779)","h5","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis.",1030.29,"162635-04-3",{"v":67,"d":"67.00"},65.03,"<1","N/A","http://selleckchem.com/products/Temsirolimus.html","C56H87NO16","free base","NSC 683864,CCI-779","COC1CC(CCC1OC(=O)C(C)(CO)CO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.039,12,3,11]
["S1047","Vorinostat (SAHA)","a6","L3900-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1","N/A","http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1048","Tozasertib","b6","L3900-01","in 10mM DMSO","Aurora Kinase,Autophagy,Bcr-Abl,FLT3","Cell Cycle","Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.",464.59,"639089-54-6",{"v":93,"d":"93.00"},200.18,"<1","N/A","http://selleckchem.com/products/VX-680(MK-0457).html","C23H28N8OS","free base","VX-680, MK-0457","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)SC4=CC=C(NC(=O)C5CC5)C=C4",4.445,4,3,7]
["S1049","Y-27632 2HCl","c6","L3900-01","in 10mM DMSO","Autophagy,ROCK","Cell Cycle","Y-27632 2HCl is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",320.26,"129830-38-2",{"v":64,"d":"64.00"},199.84,{"v":14,"d":"14.00"},43.71,"http://selleckchem.com/products/Y-27632.html","C14H21N3O.2HCl","Dihydrochloride","N/A","Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.871,2,2,3]
["S1052","Elesclomol (STA-4783)","d6","L3900-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.",{"v":400.5,"d":"400.50"},"488832-69-5",{"v":80,"d":"80.00"},199.75,"<1","N/A","http://selleckchem.com/products/Elesclomol.html","C19H20N4O2S2","free base","N/A","CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2",2.885,2,2,8]
["S1053","Entinostat (MS-275)","e6","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.",376.41,"209783-80-2",{"v":75,"d":"75.00"},199.25,"<1","N/A","http://selleckchem.com/products/MS-275.html","C21H20N4O3","free base","SNDX-275","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC(=O)OCC3=CN=CC=C3)C=C2",2.071,4,3,7]
["S1055","Enzastaurin (LY317615)","f6","L3900-01","in 10mM DMSO","PKC","TGF-beta/Smad","Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.",515.61,"170364-57-5",{"v":30,"d":"30.00"},58.18,"<1","N/A","http://selleckchem.com/products/Enzastaurin.html","C32H29N5O2","free base","N/A","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](C5CCN(CC5)CC6=NC=CC=C6)C7=CC=CC=C47",{"v":4.32,"d":"4.320"},3,1,5]
["S1056","AC480 (BMS-599626)","g6","L3900-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.",530.55,"714971-09-2",{"v":113,"d":"113.00"},212.99,"<1","N/A","http://selleckchem.com/products/BMS-599626.html","C27H27FN8O3","free base","N/A","CC1=C2[N](C=C1NC(=O)OCC3COCCN3)N=CN=C2NC4=CC5=C(C=C4)[N](CC6=CC=CC(=C6)F)N=C5",3.726,6,3,8]
["S1057","Obatoclax Mesylate (GX15-070)","h6","L3900-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1","N/A","http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","a7","L3900-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,"N/A","N/A","http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1061","Nutlin-3","b7","L3900-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1064","Masitinib (AB1010)","c7","L3900-01","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","Masitinib is a novel inhibitor for Kit (c-Kit) and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3.",498.64,"790299-79-5",{"v":100,"d":"100.00"},200.55,"<1","N/A","http://selleckchem.com/products/Masitinib-(AB1010).html","C28H30N6OS","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC(=C(C)C=C3)NC4=NC(=CS4)C5=CC=CN=C5",4.475,3,2,7]
["S1065","Pictilisib (GDC-0941)","d7","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,PI3K","PI3K/Akt/mTOR","Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.",513.64,"957054-30-7",{"v":44,"d":"44.00"},85.66,"<1","N/A","http://selleckchem.com/products/GDC-0941.html","C23H27N7O3S2","free base","RG7321","C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6",2.153,6,1,5]
["S1067","SB431542","e7","L3900-01","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.",384.39,"301836-41-9",{"v":76,"d":"76.00"},197.72,"<1","N/A","http://selleckchem.com/products/SB-431542.html","C22H16N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=NC=CC=C3)C4=CC5=C(OCO5)C=C4",3.447,5,2,4]
["S1068","Crizotinib (PF-02341066)","f7","L3900-01","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",450.34,"877399-52-5",{"v":9,"d":"9.00"},19.98,"<1","N/A","http://selleckchem.com/products/PF-2341066.html","C21H22Cl2FN5O","free base","PF-02341066","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S1069","Luminespib (NVP-AUY922)","g7","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),IGF-1R","Cytoskeletal Signaling","Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.",465.54,"747412-49-3",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/NVP-AUY922.html","C26H31N3O5","free base","AUY-922, VER-52296","CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C",4.069,4,3,7]
["S1070","PHA-665752","h7","L3900-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM in cell-free assays,  >50-fold selectivity for c-Met than RTKs or STKs.",641.61,"477575-56-7",{"v":128,"d":"128.00"},{"v":199.5,"d":"199.50"},"<1","N/A","http://selleckchem.com/products/PHA-665752.html","C32H34Cl2N4O4S","free base","N/A","CC1=C(C(=C([NH]1)/C=C/2C(=O)NC3=C2C=C(C=C3)[S](=O)(=O)CC4=C(Cl)C=CC=C4Cl)C)C(=O)N5CCCC5CN6CCCC6",5.689,4,2,7]
["S1071","HA14-1","a8","L3900-01","in 10mM DMSO","Bcl-2","Apoptosis","HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.",409.23,"65673-63-4",{"v":82,"d":"82.00"},200.38,"<1","N/A","http://selleckchem.com/products/HA14-1.html","C17H17BrN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Br",2.511,5,1,7]
["S1072","ZSTK474","b8","L3900-01","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2.",417.41,"475110-96-4",{"v":21,"d":"21.00"},50.31,"<1","N/A","http://selleckchem.com/products/ZSTK474.html","C19H21F2N7O2","free base","N/A","FC(F)C1=NC2=C(C=CC=C2)[N]1C3=NC(=NC(=N3)N4CCOCC4)N5CCOCC5",3.366,6,0,4]
["S1076","Adezmapimod (SB203580)","c8","L3900-01","in 10mM DMSO","Mitophagy,p38 MAPK","MAPK","Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.",377.43,"152121-47-6",{"v":43,"d":"43.00"},113.93,"<1","N/A","http://selleckchem.com/products/SB-203580.html","C21H16FN3OS","Free Base","RWJ 64809, PB 203580","C[S](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",3.883,3,1,4]
["S1078","MK-2206 2HCl","d8","L3900-01","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.",480.39,"1032350-13-2",{"v":14,"d":"14.00"},29.14,"<1","N/A","http://selleckchem.com/products/MK-2206.html","C25H21N5O.2HCl","Dihydrochloride","N/A","Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6",4.183,3,2,3]
["S1080","SU11274","e8","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Met","Protein Tyrosine Kinase","SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest.",568.09,"658084-23-2",{"v":92,"d":"92.00"},161.95,"<1","N/A","http://selleckchem.com/products/SU11274.html","C28H30CIN5O4S","free base","PKI-SU11274","CN1CCN(CC1)C(=O)C2=C(C)[NH]C(=C2C)/C=C/3C(=O)NC4=C3C=C(C=C4)[S](=O)(=O)N(C)C5=CC(=CC=C5)Cl",3.477,4,2,5]
["S1082","Vismodegib (GDC-0449)","f8","L3900-01","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.",{"v":421.3,"d":"421.30"},"879085-55-9",{"v":84,"d":"84.00"},199.38,"<1","N/A","http://selleckchem.com/products/GDC-0449.html","C19H14Cl2N2O3S","free base","GDC-0449","C[S](=O)(=O)C1=CC=C(C(=C1)Cl)C(=O)NC2=CC(=C(Cl)C=C2)C3=NC=CC=C3",4.265,4,1,4]
["S1084","Brivanib (BMS-540215)","g8","L3900-01","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.",370.38,"649735-46-6",{"v":74,"d":"74.00"},199.79,"<1","N/A","http://selleckchem.com/products/Brivanib.html","C19H19FN4O3","free base","N/A","CC(O)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.481,4,2,5]
["S1085","Belinostat (PXD101)","h8","L3900-01","in 10mM DMSO","Autophagy,HDAC","Epigenetics","Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.",318.35,"866323-14-0",{"v":64,"d":"64.00"},201.04,"<1","N/A","http://selleckchem.com/products/Belinostat.html","C15H14N2O4S","free base","PXD101,NSC726630, PX-105684","ONC(=O)/C=C/C1=CC(=CC=C1)[S](=O)(=O)NC2=CC=CC=C2",{"v":1.8,"d":"1.800"},3,2,5]
["S1087","Iniparib (BSI-201)","a9","L3900-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Iniparib (BSI-201, NSC-746045, IND-71677) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.",292.03,"160003-66-7",{"v":58,"d":"58.00"},198.61,"<1","N/A","http://selleckchem.com/products/BSI-201.html","C7H5IN2O3","free base","NSC-746045, IND-71677","NC(=O)C1=CC(=C(I)C=C1)[N+]([O-])=O",1.304,1,1,2]
["S1089","Refametinib (RDEA119)","b9","L3900-01","in 10mM DMSO","MEK","MAPK","Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.",572.34,"923032-37-5",{"v":100,"d":"100.00"},174.72,"<1","N/A","http://selleckchem.com/products/refametinib-rdea119-bay86-9766.html","C19H20F3IN2O5S","free base","Bay 86-9766","COC1=C(N[S](=O)(=O)C2(CC2)CC(O)CO)C(=C(F)C(=C1)F)NC3=CC=C(I)C=C3F",2.827,3,4,9]
["S1090","Abexinostat (PCI-24781)","c9","L3900-01","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.",397.42,"783355-60-2",{"v":80,"d":"80.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/PCI-24781.html","C21H23N3O5","free base","CRA-024781","CN(C)CC1=C(OC2=CC=CC=C12)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO",2.353,4,2,8]
["S1091","Linsitinib (OSI-906)","d9","L3900-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.",421.49,"867160-71-2",{"v":84,"d":"84.00"},199.29,"<1","N/A","http://selleckchem.com/products/OSI-906.html","C26H23N5O","free base","N/A","CC1(O)CC(C1)C2=NC(=C3[N]2C=CN=C3N)C4=CC=C5C=CC(=NC5=C4)C6=CC=CC=C6",3.757,3,1,3]
["S1092","KU-55933 (ATM Kinase Inhibitor)","e9","L3900-01","in 10mM DMSO","ATM/ATR,Autophagy,ULK","DNA Damage/DNA Repair","KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.",395.49,"587871-26-9",{"v":33,"d":"33.00"},83.44,"<1","N/A","http://selleckchem.com/products/KU-55933.html","C21H17NO3S2","free base","N/A","O=C1C=C(OC(=C1)C2=CC=CC3=C2SC4=CC=CC=C4S3)N5CCOCC5",4.393,3,0,2]
["S1094","PF-04217903","f9","L3900-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1.",372.38,"956905-27-4",{"v":5,"d":"5.00"},13.43,"<1","N/A","http://selleckchem.com/products/PF-04217903.html","C19H16N8O","free base","N/A","OCC[N]1C=C(C=N1)C2=NC3=C(N=C2)N=N[N]3CC4=CC5=CC=CN=C5C=C4",1.561,6,1,5]
["S1095","Dacinostat (LAQ824)","g9","L3900-01","in 10mM DMSO","HDAC,p21","Epigenetics","Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.",379.46,"404951-53-7",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/LAQ824(NVP-LAQ824).html","C22H25N3O3","free base","NVP-LAQ824","OCCN(CCC1=C[NH]C2=C1C=CC=C2)CC3=CC=C(\\C=C\\C(=O)NO)C=C3",3.045,1,3,9]
["S1096","Quisinostat (JNJ-26481585) 2HCl","h9","L3900-01","in 10mM DMSO","HDAC","Epigenetics","Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.",467.39,"875320-31-3",{"v":79,"d":"79.00"},169.02,"<1","N/A","http://selleckchem.com/products/JNJ-26481585.html","C21H28Cl2N6O2","Dihydrochloride","N/A","Cl.Cl.C[N]1C=C(CNCC2CCN(CC2)C3=NC=C(C=N3)C(=O)NO)C4=CC=CC=C14",2.749,3,2,6]
["S1097","BTZ043 Racemate","a10","L3900-01","in 10mM DMSO","Bacterial","Microbiology","BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.",431.39,"957217-65-1",{"v":22,"d":"22.00"},{"v":51,"d":"51.00"},"<1","N/A","http://selleckchem.com/products/BTZ043.html","C17H16F3N3O5S","free base","N/A","CC1COC2(CCN(CC2)C3=NC(=O)C4=CC(=CC(=C4S3)[N+]([O-])=O)C(F)(F)F)O1",3.515,4,0,3]
["S1098","Rucaparib (AG-014699) phosphate","b10","L3900-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.",421.36,"459868-92-9",{"v":84,"d":"84.00"},199.35,"<1","N/A","http://selleckchem.com/products/AG-014699.html","C19H18FN3O.H3PO4","Phosphate","PF-01367338","CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)[NH]2)F.O[P](O)(O)=O",{"v":2.49,"d":"2.490"},1,3,3]
["S1100","MLN8054","c10","L3900-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.",476.86,"869363-13-3",{"v":95,"d":"95.00"},199.22,"<1","N/A","http://selleckchem.com/products/MLN8054.html","C25H15ClF2N4O2","free base","N/A","OC(=O)C1=CC=C(NC2=NC3=C(CN=C(C4=CC(=CC=C34)Cl)C5=C(F)C=CC=C5F)C=N2)C=C1",6.192,4,1,4]
["S1101","Vatalanib (PTK787) 2HCl","d10","L3900-01","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Vatalanib 2HCl (PTK787, ZK 222584, cpg-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM in a cell-free assay, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 3.",419.73,"212141-51-0",{"v":85,"d":"85.00"},202.51,{"v":10,"d":"10.00"},23.82,"http://selleckchem.com/products/Vatalanib,Dihydrochloride-Salt.html","C20H15ClN4.2HCl","Dihydrochloride","ZK 222584 (cpg-79787) 2HCl","Cl.Cl.ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C24)C=C1",5.469,3,1,4]
["S1102","U0126-EtOH","e10","L3900-01","in 10mM DMSO","Antiviral,Autophagy,MEK,Mitophagy","MAPK","U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.",426.56,"1173097-76-1",{"v":85,"d":"85.00"},199.27,"<1","N/A","http://selleckchem.com/products/U0126.html","C18H16N6S2.C2H6O","Ethanolate","N/A","CCO.N\\C(SC1=CC=CC=C1N)=C(C#N)\\C(C#N)=C(N)/SC2=CC=CC=C2N",2.169,0,5,5]
["S1103","ZM 447439","f10","L3900-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.",513.59,"331771-20-1",{"v":103,"d":"103.00"},200.55,"<1","N/A","http://selleckchem.com/products/ZM-447439.html","C29H31N5O4","free base","N/A","COC1=C(OCCCN2CCOCC2)C=C3N=CN=C(NC4=CC=C(NC(=O)C5=CC=CC=C5)C=C4)C3=C1",4.118,6,2,10]
["S1105","LY294002","g10","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase,DNA-PK,PI3K","PI3K/Akt/mTOR","LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.",307.34,"154447-36-6",{"v":36,"d":"36.00"},117.13,"<1","N/A","http://selleckchem.com/products/LY294002.html","C19H17NO3","free base","SF 1101, NSC 697286","O=C1C=C(OC2=C(C=CC=C12)C3=CC=CC=C3)N4CCOCC4",3.342,3,0,2]
["S1106","OSU-03012 (AR-12)","h10","L3900-01","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.",460.45,"742112-33-0",{"v":11,"d":"11.00"},23.89,"<1","N/A","http://selleckchem.com/products/OSU-03012.html","C26H19F3N4O","free base","N/A","NCC(=O)NC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC4=C(C=C3)C5=C(C=CC=C5)C=C4)C(F)(F)F",5.212,2,2,5]
["S1107","Danusertib (PHA-739358)","a11","L3900-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,Bcr-Abl,c-RET,FGFR,Trk receptor","Cell Cycle","Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.",474.55,"827318-97-8",{"v":95,"d":"95.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHA-739358(Danusertib).html","C26H30N6O3","free base","N/A","COC(C(=O)N1CC2=C(C1)C(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CCN(C)CC4)C5=CC=CC=C5",2.337,4,2,6]
["S1109","BI 2536","b11","L3900-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Myc,PLK","Cell Cycle","BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.",521.66,"755038-02-9",{"v":21,"d":"21.00"},40.26,"<1","N/A","http://selleckchem.com/products/BI-2536.html","C28H39N7O3","free base","N/A","CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5",3.548,5,2,7]
["S1110","Varespladib (LY315920)","c11","L3900-01","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.",380.39,"172732-68-2",{"v":76,"d":"76.00"},199.79,"<1","N/A","http://selleckchem.com/products/LY315920(Varespladib).html","C21H20N2O5","free base","N/A","CCC1=C(C(=O)C(N)=O)C2=C(C=CC=C2OCC(O)=O)[N]1CC3=CC=CC=C3",3.078,4,1,8]
["S1111","Foretinib (GSK1363089)","d11","L3900-01","in 10mM DMSO","c-Kit,c-Met,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Foretinib (GSK1363089, EXEL-2880, XL-880, GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.",632.65,"849217-64-7",{"v":100,"d":"100.00"},158.07,"<1","N/A","http://selleckchem.com/products/XL880(GSK1363089,EXEL-2880).html","C34H34F2N4O6","free base","EXEL-2880, XL-880, GSK089","COC1=CC2=C(C=C1OCCCN3CCOCC3)N=CC=C2OC4=C(F)C=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4",4.437,7,2,12]
["S1113","GSK690693","e11","L3900-01","in 10mM DMSO","Akt,AMPK,Autophagy,DAPK,PKA,PKC,STING,ULK","PI3K/Akt/mTOR","GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.",425.48,"937174-76-0",{"v":39,"d":"39.00"},91.66,"<1","N/A","http://selleckchem.com/products/GSK690693.html","C21H27N7O3","free base","N/A","CC[N]1C(=NC2=C1C(=CN=C2C#CC(C)(C)O)OCC3CCCNC3)C4=NON=C4N",1.839,6,2,7]
["S1114","JNJ-38877605","f11","L3900-01","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Phase 1.",377.35,"943540-75-8",{"v":37,"d":"37.00"},98.05,"<1","N/A","http://selleckchem.com/products/JNJ-38877605.html","C19H13F2N7","free base","N/A","C[N]1C=C(C=N1)C2=N[N]3C(=NN=C3C(F)(F)C4=CC5=C(C=C4)N=CC=C5)C=C2",3.052,5,0,3]
["S1115","Odanacatib (MK-0822)","g11","L3900-01","in 10mM DMSO","Cysteine Protease","Proteases","Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.",525.56,"603139-19-1",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/Odanacatib-(MK0822).html","C25H27F4N3O3S","free base","N/A","CC(C)(F)CC(NC(C1=CC=C(C=C1)C2=CC=C(C=C2)[S](C)(=O)=O)C(F)(F)F)C(=O)NC3(CC3)C#N",3.978,3,2,10]
["S1117","Triciribine (NSC 154020)","h11","L3900-01","in 10mM DMSO","Akt,DNA/RNA Synthesis,HIV","PI3K/Akt/mTOR","Triciribine (NSC 154020, VD-0002, vqd-002, API-2, TCN) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.",{"v":320.3,"d":"320.30"},"35943-35-2",{"v":64,"d":"64.00"},199.81,"<1","N/A","http://selleckchem.com/products/Triciribine.html","C13H16N6O4","free base","VD-0002, vqd-002, API-2, TCN","CN1N=C(N)C2=C[N](C3OC(CO)C(O)C3O)C4=C2C1=NC=N4",-1.119,4,4,2]
["S1119","Cabozantinib (BMS-907351)","a2","L3900-02","in 10mM DMSO","Apoptosis related,Axl,c-Met,VEGFR","Protein Tyrosine Kinase","Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.",501.51,"849217-68-1",{"v":100,"d":"100.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://selleckchem.com/products/XL184.html","C28H24FN3O5","Free Base","XL184,BMS-907351","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3",4.342,6,2,8]
["S1120","Everolimus (RAD001)","b2","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1","N/A","http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1122","Mocetinostat (MGCD0103)","c2","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.",396.44,"726169-73-9",{"v":13,"d":"13.00"},32.79,"<1","N/A","http://selleckchem.com/products/MGCD0103(Mocetinostat).html","C23H20N6O","free base","MG0103","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC3=NC=CC(=N3)C4=CC=CN=C4)C=C2",2.798,4,3,6]
["S1124","BMS-754807","d2","L3900-02","in 10mM DMSO","c-Met,IGF-1R,RON,Trk receptor","Protein Tyrosine Kinase","BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.",461.49,"1001350-96-4",{"v":92,"d":"92.00"},199.35,"<1","N/A","http://selleckchem.com/products/BMS-754807.html","C23H24FN9O","free base","N/A","CC1(CCCN1C2=N[N]3C=CC=C3C(=N2)NC4=N[NH]C(=C4)C5CC5)C(=O)NC6=CC=C(F)N=C6",4.069,5,3,6]
["S1129","SRT1720 HCl","e2","L3900-02","in 10mM DMSO","Autophagy,Sirtuin","Epigenetics","SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.",506.02,"1001645-58-4",{"v":38,"d":"38.00"},{"v":75.1,"d":"75.10"},"<1","N/A","http://selleckchem.com/products/SRT1720.html","C25H23N7OS.HCl","Hydrochloride","N/A","Cl.O=C(NC1=CC=CC=C1C2=C[N]3C(=CSC3=N2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5",3.018,4,2,5]
["S1130","Sepantronium Bromide","f2","L3900-02","in 10mM DMSO","Autophagy,IAP,Survivin","Apoptosis","Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.",443.29,"781661-94-7",{"v":55,"d":"55.00"},124.07,{"v":89,"d":"89.00"},200.77,"http://selleckchem.com/products/YM155.html","C20H19BrN4O3","Bromide","YM155","[Br-].COCC[N]1C(=[N+](CC2=CN=CC=N2)C3=C1C(=O)C4=C(C=CC=C4)C3=O)C",-0.733,5,0,5]
["S1132","3-Aminobenzamide","g2","L3900-02","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.",136.15,"3544-24-9",{"v":27,"d":"27.00"},198.31,"<1","N/A","https://www.selleckchem.com/products/3-aminobenzamide.html","C7H8N2O","free base","3-ABA , 3-amino Benzamide, 3-AB","NC(=O)C1=CC(=CC=C1)N",0.085,1,2,1]
["S1133","Alisertib (MLN8237)","h2","L3900-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy","Cell Cycle","Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.",518.92,"1028486-01-2",{"v":27,"d":"27.00"},52.03,"<1","N/A","http://selleckchem.com/products/MLN8237.html","C27H20ClFN4O4","free base","N/A","COC1=C(C(=CC=C1)F)C2=NCC3=C(N=C(NC4=CC(=C(C=C4)C(O)=O)OC)N=C3)C5=C2C=C(Cl)C=C5",5.954,6,1,6]
["S1134","AT9283","a3","L3900-02","in 10mM DMSO","Aurora Kinase,Bcr-Abl,JAK","JAK/STAT","AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I).",381.43,"896466-04-9",{"v":76,"d":"76.00"},199.25,"<1","N/A","http://selleckchem.com/products/AT9283.html","C19H23N7O2","free base","N/A","O=C(NC1CC1)NC2=C[NH]N=C2C3=NC4=CC(=CC=C4[NH]3)CN5CCOCC5",{"v":1.51,"d":"1.510"},4,4,5]
["S1138","Brivanib Alaninate (BMS-582664)","b3","L3900-02","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.",441.46,"649735-63-7",{"v":88,"d":"88.00"},199.34,"<1","N/A","http://selleckchem.com/products/Brivanib-alaninate.html","C22H24FN5O4","Alaninate","N/A","CC(N)C(=O)OC(C)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.383,6,2,8]
["S1141","Tanespimycin (17-AAG)","c3","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),Mitophagy","Cytoskeletal Signaling","Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.",585.69,"75747-14-7",{"v":100,"d":"100.00"},170.74,"<1","N/A","http://selleckchem.com/products/17-AAG(Geldanamycin).html","C31H43N3O8","free base","CP127374, NSC-330507, KOS 953","COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.524,7,4,7]
["S1142","Alvespimycin (17-DMAG) HCl","d3","L3900-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay.",653.21,"467214-21-7",{"v":131,"d":"131.00"},200.55,"<1","N/A","http://selleckchem.com/products/17-DMAG,Hydrochloride-Salt.html","C32H48N4O8.HCl","Hydrochloride","NSC 707545,BMS 826476 HCl,KOS 1022","Cl.COC1CC(C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.428,7,4,8]
["S1143","AG-490 (Tyrphostin B42)","e3","L3900-02","in 10mM DMSO","EGFR,JAK","Protein Tyrosine Kinase","AG-490 (Tyrphostin B42, Zinc02557947) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.",{"v":294.3,"d":"294.30"},"133550-30-8",{"v":58,"d":"58.00"},197.08,"<1","N/A","http://selleckchem.com/products/AG-490.html","C17H14N2O3","free base","Zinc02557947","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NCC2=CC=CC=C2",2.444,1,3,4]
["S1144","Ivacaftor (VX-770)","f3","L3900-02","in 10mM DMSO","CFTR","Transmembrane Transporters","Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.",392.49,"873054-44-5",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/VX-770.html","C24H28N2O3","free base","VX-770","CC(C)(C)C1=CC(=C(NC(=O)C2=CNC3=C(C=CC=C3)C2=O)C=C1O)C(C)(C)C",4.516,2,3,4]
["S1145","SNS-032 (BMS-387032)","g3","L3900-02","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.",380.53,"345627-80-7",{"v":76,"d":"76.00"},199.72,"<1","N/A","http://selleckchem.com/products/SNS-032.html","C17H24N4O2S2","free base","N/A","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1",{"v":2.07,"d":"2.070"},4,2,6]
["S1147","Barasertib (AZD1152-HQPA)","h3","L3900-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.",507.56,"722544-51-6",{"v":102,"d":"102.00"},200.96,"<1","N/A","http://selleckchem.com/products/AZD1152-HQPA.html","C26H30FN7O3","free base","AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib","CCN(CCO)CCCOC1=CC=C2C(=NC=NC2=C1)NC3=CC(=N[NH]3)CC(=O)NC4=CC=CC(=C4)F",3.493,5,4,13]
["S1148","Docetaxel (RP56976)","a4","L3900-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",807.88,"114977-28-5",{"v":100,"d":"100.00"},123.78,"<1","N/A","http://selleckchem.com/products/Docetaxel(Taxotere).html","C43H53NO14","Free Base","NSC 628503,RP56976","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",2.586,10,4,13]
["S1150","Paclitaxel (NSC 125973)","b4","L3900-02","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.",853.91,"33069-62-4",{"v":171,"d":"171.00"},200.26,"<1","N/A","http://selleckchem.com/products/Paclitaxel(Taxol).html","C47H51NO14","free base","PTX, Taxol, Onxal, Abraxane,NSC 125973","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S1152","PLX-4720","c4","L3900-02","in 10mM DMSO","Raf","MAPK","PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.",413.83,"918505-84-7",{"v":83,"d":"83.00"},200.57,"<1","N/A","http://selleckchem.com/products/PLX-4720.html","C17H14ClF2N3O3S","free base","N/A","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(Cl)C=C23",3.435,4,2,6]
["S1153","Roscovitine (CYC202)","d4","L3900-02","in 10mM DMSO","CDK","Cell Cycle","Roscovitine (CYC202, Seliciclib, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6. Phase 2.",354.45,"186692-46-6",{"v":71,"d":"71.00"},200.31,"<1","N/A","http://selleckchem.com/products/Roscovitine.html","C19H26N6O","free base","Seliciclib, R-roscovitine","CCC(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=CC=C3",{"v":3.32,"d":"3.320"},3,3,8]
["S1154","SNS-314","e4","L3900-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.",430.93,"1057249-41-8",{"v":105,"d":"105.00"},243.66,{"v":6,"d":"6.00"},13.92,"http://selleckchem.com/products/sns-314-mesylate.html","C18H15ClN6OS2","Mesylate","N/A","C[S](O)(=O)=O.ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.539,4,3,6]
["S1156","Capecitabine (RO 09-1978)","f4","L3900-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis","DNA Damage/DNA Repair","Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.",359.35,"154361-50-9",{"v":72,"d":"72.00"},200.36,{"v":6,"d":"6.00"},{"v":16.7,"d":"16.70"},"http://selleckchem.com/products/Capecitabine(Xeloda).html","C15H22FN3O6","free base","RO 09-1978","CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2OC(C)C(O)C2O",{"v":0.82,"d":"0.820"},5,3,7]
["S1157","Delanzomib (CEP-18770)","g4","L3900-02","in 10mM DMSO","Proteasome","Proteases","Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2.",413.28,"847499-27-8",{"v":83,"d":"83.00"},200.83,"<1","N/A","http://selleckchem.com/products/cep-18770.html","C21H28BN3O5","free base","N/A","CC(C)C(CNC(=O)C(NC(=O)C1=NC(=CC=C1)C2=CC=CC=C2)C(C)O)B(O)O",2.646,3,3,9]
["S1158","MK-8245","h4","L3900-02","in 10mM DMSO","SCD","Metabolism","MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.",467.25,"1030612-90-8",{"v":93,"d":"93.00"},199.04,"<1","N/A","http://selleckchem.com/products/mk-8245.html","C17H16BrFN6O4","free base","N/A","OC(=O)C[N]1N=NC(=N1)C2=CC(=NO2)N3CCC(CC3)OC4=CC(=CC=C4Br)F",2.991,7,0,6]
["S1159","Ganetespib (STA-9090)","a5","L3900-02","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.",{"v":364.4,"d":"364.40"},"888216-25-9",{"v":40,"d":"40.00"},109.77,"<1","N/A","http://selleckchem.com/products/ganetespib-sta-9090.html","C20H20N4O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)[N](C)C=C4",3.866,2,3,3]
["S1162","Pretomanid (PA-824)","b5","L3900-02","in 10mM DMSO","Bacterial","Microbiology","PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.Phase 2.",359.26,"187235-37-6",{"v":72,"d":"72.00"},200.41,"<1","N/A","http://selleckchem.com/products/pa-824.html","C14H12F3N3O5","free base","N/A","[O-][N+](=O)C1=C[N]2CC(COC2=N1)OCC3=CC=C(OC(F)(F)F)C=C3",4.301,4,0,6]
["S1163","Onalespib (AT13387)","c5","L3900-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.",409.52,"912999-49-6",{"v":25,"d":"25.00"},61.05,"<1","N/A","http://selleckchem.com/products/at13387.html","C24H31N3O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C(=O)N2CC3=C(C2)C=C(CN4CCN(C)CC4)C=C3",3.322,1,2,4]
["S1164","Lenvatinib (E7080)","d5","L3900-02","in 10mM DMSO","c-Kit,c-RET,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Lenvatinib (E7080) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3.",426.85,"417716-92-8",{"v":40,"d":"40.00"},93.71,"<1","N/A","http://selleckchem.com/products/E7080.html","C21H19ClN4O4","free base","N/A","COC1=C(C=C2C(=CC=NC2=C1)OC3=CC(=C(NC(=O)NC4CC4)C=C3)Cl)C(N)=O",2.832,5,3,6]
["S1165","ABT-751 (E7010)","e5","L3900-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.",371.41,"141430-65-1",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/ABT-751.html","C18H17N3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(NC3=CC=C(O)C=C3)N=CC=C2",2.997,4,3,6]
["S1167","CP-724714","f5","L3900-02","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.",469.53,"537705-08-1",{"v":94,"d":"94.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://selleckchem.com/products/CP-724714.html","C27H27N5O3","free base","N/A","COCC(=O)NC/C=C/C1=CC=C2N=CN=C(NC3=CC=C(OC4=CC=C(C)N=C4)C(=C3)C)C2=C1",3.987,6,2,9]
["S1168","Valproic Acid (NSC 93819) sodium salt","g5","L3900-02","in 10mM DMSO","Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1α","Neuronal Signaling","Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.",166.19,"1069-66-5",{"v":33,"d":"33.00"},198.57,{"v":33,"d":"33.00"},198.57,"http://selleckchem.com/products/Sodium-valproate.html","C8H15NaO2","Sodium salt","Sodium valproate,NSC 93819,2-Propylpentanoic Acid","CCCC(CCC)C(=O)O[Na]",1.275,0,0,5]
["S1169","TGX-221","h5","L3900-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, 1000-fold more selective for p110β than p110α.",364.44,"663619-89-4",{"v":12,"d":"12.00"},32.93,"<1","N/A","http://selleckchem.com/products/TGX-221.html","C21H24N4O2","free base","N/A","CC(NC1=CC=CC=C1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.373,3,1,4]
["S1171","CYC116","a6","L3900-02","in 10mM DMSO","Aurora Kinase,VEGFR","Cell Cycle","CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.",368.46,"693228-63-6",{"v":24,"d":"24.00"},65.14,"<1","N/A","http://selleckchem.com/products/CYC116.html","C18H20N6OS","free base","N/A","CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.743,4,2,4]
["S1172","Serdemetan (JNJ-26854165)","b6","L3900-02","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1175","BIIB021","c6","L3900-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.",318.76,"848695-25-0",{"v":64,"d":"64.00"},200.78,"<1","N/A","http://selleckchem.com/products/BIIB021.html","C14H15ClN6O","free base","CNF2024","COC1=C(C)C=NC(=C1C)C[N]2C=NC3=C(Cl)N=C(N)N=C23",2.223,5,1,3]
["S1176","Plinabulin (NPI-2358)","d6","L3900-02","in 10mM DMSO","Microtubule Associated,VDA","Angiogenesis","Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.",336.39,"714272-27-2",{"v":54,"d":"54.00"},160.53,"<1","N/A","http://selleckchem.com/products/NPI-2358.html","C19H20N4O2","free base","N/A","CC(C)(C)C1=C(/C=C/2NC(=O)C(/NC2=O)=C/C3=CC=CC=C3)N=C[NH]1",1.921,3,3,3]
["S1178","Regorafenib (BAY 73-4506)","e6","L3900-02","in 10mM DMSO","Autophagy,c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY 73-4506,Fluoro-Sorafenib, Resihance, Stivarga) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.",482.82,"755037-03-7",{"v":97,"d":"97.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://selleckchem.com/products/BAY-73-4506.html","C21H15ClF4N4O3","free base","Fluoro-Sorafenib, Resihance, Stivarga,BAY 73-4506","CNC(=O)C1=CC(=CC=N1)OC2=CC(=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)F",4.381,4,3,6]
["S1180","XAV-939","f6","L3900-02","in 10mM DMSO","PARP,Wnt/beta-catenin","Stem Cells & Wnt","XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.",312.31,"284028-89-3",{"v":12,"d":"12.00"},38.42,"<1","N/A","http://selleckchem.com/products/XAV-939.html","C14H11F3N2OS","free base","NVP-XAV939","OC1=C2CSCCC2=NC(=N1)C3=CC=C(C=C3)C(F)(F)F",3.676,2,1,2]
["S1181","ENMD-2076","g6","L3900-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,CSF-1R,FGFR,FLT3,PDGFR,Src,VEGFR","Angiogenesis","ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.",375.47,"934353-76-1",{"v":105,"d":"105.00"},279.65,{"v":1,"d":"1.00"},2.66,"http://selleckchem.com/products/enmd-2076.html","C21H25N7","Tartaric Acid","N/A","CN1CCN(CC1)C2=CC(=NC(=N2)\\C=C\\C3=CC=CC=C3)NC4=N[NH]C(=C4)C",4.015,3,2,5]
["S1183","Danoprevir (ITMN-191)","h6","L3900-02","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Danoprevir (ITMN-191, RG7227) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2.",731.83,"850876-88-9",{"v":144,"d":"144.00"},196.77,"<1","N/A","http://selleckchem.com/products/Danoprevir.html","C35H46FN5O9S","free base","RG7227","CC(C)(C)OC(=O)NC1CCCCC\\C=C/C2CC2(NC(=O)C3CC(CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)N[S](=O)(=O)C6CC6",2.922,9,3,8]
["S1185","Ritonavir (ABT-538)","a7","L3900-02","in 10mM DMSO","Apoptosis related,COVID-19,HIV Protease,P450 (e.g. CYP17)","Proteases","Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.",720.94,"155213-67-5",{"v":100,"d":"100.00"},138.71,"<1","N/A","http://selleckchem.com/products/Ritonavir.html","C37H48N6O5S2","free base","ABT-538,A 84538, RTV, Norvir, Norvir Softgel","CC(C)C(NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)CC4=CC=CC=C4",4.978,6,4,18]
["S1188","Anastrozole (ZD-1033)","b7","L3900-02","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Anastrozole (Arimidex,ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.",293.37,"120511-73-1",{"v":59,"d":"59.00"},201.11,"<1","N/A","http://selleckchem.com/products/Anastrozole.html","C17H19N5","free base","Arimidex,ZD-1033","CC(C)(C#N)C1=CC(=CC(=C1)C[N]2C=NC=N2)C(C)(C)C#N",2.965,2,0,4]
["S1189","Aprepitant (MK-0869)","c7","L3900-02","in 10mM DMSO","CSF-1R,HIV,Interleukins,Neurokinin Receptor,TNF-alpha","Neuronal Signaling","Aprepitant (MK-0869, L-754030, Emend) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.",534.43,"170729-80-3",{"v":107,"d":"107.00"},200.21,"<1","N/A","http://selleckchem.com/products/Aprepitant.html","C23H21F7N4O3","free base","MK-0869, L-754030, Emend","CC(OC1OCCN(CC2=NNC(=O)N2)C1C3=CC=C(F)C=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",4.635,4,2,8]
["S1190","Bicalutamide (ICI-176334)","d7","L3900-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.",430.37,"90357-06-5",{"v":86,"d":"86.00"},199.83,"<1","N/A","http://selleckchem.com/products/Bicalutamide(Casodex).html","C18H14F4N2O4S","free base","ICI-176334","CC(O)(C[S](=O)(=O)C1=CC=C(F)C=C1)C(=O)NC2=CC=C(C#N)C(=C2)C(F)(F)F",2.926,3,1,6]
["S1191","Fulvestrant (ICI-182780)","e7","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor","Endocrinology & Hormones","Fulvestrant (ICI-182780, ZD 9238, ZM 182780) is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity.",606.77,"129453-61-8",{"v":100,"d":"100.00"},164.81,"<1","N/A","http://selleckchem.com/products/Fulvestrant.html","C32H47F5O3S","free base","ICI-182780, ZD 9238, ZM 182780","CC12CCC3C(C(CCCCCCCCC[S](=O)CCCC(F)(F)C(F)(F)F)CC4=C3C=CC(=C4)O)C1CCC2O",8.437,1,2,15]
["S1192","Raltitrexed","f7","L3900-02","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.",458.49,"112887-68-0",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/Raltitrexed.html","C21H22N4O6S","free base","ZD-1694, ICI-D1694, D1694","CN(CC1=CC2=C(C=C1)N=C(C)NC2=O)C3=CC=C(S3)C(=O)NC(CCC(O)=O)C(O)=O",1.528,5,2,9]
["S1193","Thalidomide (K17)","g7","L3900-02","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.",258.23,"50-35-1",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Thalidomide.html","C13H10N2O4","free base","K17","O=C1CCC(N2C(=O)C3=C(C=CC=C3)C2=O)C(=O)N1",0.097,4,1,1]
["S1194","CUDC-101","h7","L3900-02","in 10mM DMSO","EGFR,HDAC,HER2","Epigenetics","CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.",434.49,"1012054-59-9",{"v":20,"d":"20.00"},46.03,"<1","N/A","http://selleckchem.com/products/CUDC-101.html","C24H26N4O4","free base","N/A","COC1=CC2=C(C=C1OCCCCCCC(=O)NO)C(=NC=N2)NC3=CC(=CC=C3)C#C",5.376,5,2,11]
["S1195","Orteronel","a8","L3900-02","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Orteronel(TAK-700) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). TAK-700 (Orteronel) is an androgen biosynthesis inhibitor. Phase 3.",307.35,"426219-18-3",{"v":61,"d":"61.00"},198.47,"<1","N/A","http://selleckchem.com/products/TAK-700.html","C18H17N3O2","free base","TAK-700","CNC(=O)C1=CC=C2C=C(C=CC2=C1)C3(O)CC[N]4C=NC=C34",1.075,2,1,2]
["S1196","Exemestane (FCE 24304)","b8","L3900-02","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Exemestane (Aromasin,FCE24304, PNU155971,EXE) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.",{"v":296.4,"d":"296.40"},"107868-30-4",{"v":54,"d":"54.00"},182.19,"<1","N/A","http://selleckchem.com/products/Exemestane.html","C20H24O2","free base","Aromasin,FCE24304, PNU155971,EXE","CC12CCC3C(CC(=C)C4=CC(=O)C=CC34C)C1CCC2=O",3.606,2,0,0]
["S1197","Finasteride","c8","L3900-02","in 10mM DMSO","5-alpha Reductase","Endocrinology & Hormones","Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).",372.54,"98319-26-7",{"v":75,"d":"75.00"},201.32,"<1","N/A","http://selleckchem.com/products/Finasteride.html","C23H36N2O2","free base","MK-906","CC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C",3.174,2,2,2]
["S1199","Cladribine (RWJ 26251)","d8","L3900-02","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.",285.69,"4291-63-8",{"v":57,"d":"57.00"},199.52,"<1","N/A","http://selleckchem.com/products/Cladribine.html","C10H12ClN5O3","free base","Leustatin,2-CdA,2-Chloro-2′-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251","NC1=NC(=NC2=C1N=C[N]2C3CC(O)C(CO)O3)Cl",-0.259,4,3,2]
["S1200","Decitabine (NSC 127716)","e8","L3900-02","in 10mM DMSO","Apoptosis related,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","Epigenetics","Decitabine (Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.",228.21,"2353-33-5",{"v":45,"d":"45.00"},197.19,{"v":10,"d":"10.00"},43.82,"http://selleckchem.com/products/Decitabine.html","C8H12N4O4","free base","Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716","NC1=NC(=O)N(C=N1)C2CC(O)C(CO)O2",-1.093,4,3,2]
["S1201","Dimesna","f8","L3900-02","in 10mM DMSO","Others","Others","Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity.",326.34,"16208-51-8",{"v":65,"d":"65.00"},199.18,{"v":65,"d":"65.00"},199.18,"http://selleckchem.com/products/Dimesna.html","C4H8Na2O6S4","Disodium salt","BNP-7787","[Na+].[Na+].[O-][S](=O)(=O)CCSSCC[S]([O-])(=O)=O",-4.295,0,0,7]
["S1202","Dutasteride","g8","L3900-02","in 10mM DMSO","5-alpha Reductase","Endocrinology & Hormones","Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).",528.53,"164656-23-9",{"v":62,"d":"62.00"},117.31,"<1","N/A","http://selleckchem.com/products/Dutasteride.html","C27H30F6N2O2","free base","GI198745, GG-745","CC12CCC3C(CCC4NC(=O)C=CC34C)C1CCC2C(=O)NC5=CC(=CC=C5C(F)(F)F)C(F)(F)F",5.703,2,2,4]
["S1204","Melatonin (NSC 113928)","h8","L3900-02","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1","N/A","http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1206","Bisoprolol fumarate","a9","L3900-02","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker.",441.52,"104344-23-2",{"v":88,"d":"88.00"},199.31,{"v":88,"d":"88.00"},199.31,"http://selleckchem.com/products/Bisoprolol-Fumarate.html","C22H35NO8","fumarate","EMD33512","CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.OC(=O)\\C=C\\C(O)=O",-0.635,5,2,14]
["S1207","Tivozanib (AV-951)","b9","L3900-02","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Tivozanib (AV-951, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.",454.86,"475108-18-0",{"v":20,"d":"20.00"},43.97,"<1","N/A","http://selleckchem.com/products/AV-951.html","C22H19ClN4O5","free base","KRN-951","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)NC4=NOC(=C4)C)C(=C3)Cl",4.039,7,2,6]
["S1208","Doxorubicin (Adriamycin) HCl","c9","L3900-02","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1209","Fluorouracil (5-Fluorouracil, 5-FU)","d9","L3900-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,HIV,Nucleoside Analog/Antimetabolite,Thymidylate Synthase","DNA Damage/DNA Repair","Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.",130.08,"51-21-8",{"v":26,"d":"26.00"},199.88,"<1","N/A","http://selleckchem.com/products/Adrucil(Fluorouracil).html","C4H3FN2O2","free base","NSC 19893,5-Fluorouracil, 5-FU","FC1=CNC(=O)NC1=O",-1.102,2,2,0]
["S1210","Methotrexate (CL-14377)","e9","L3900-02","in 10mM DMSO","ADC Cytotoxin,DHFR","Metabolism","Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.",454.44,"59-05-2",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/Abitrexate.html","C20H22N8O5","free base","NCI-C04671, Amethopterin, CL14377, WR19039, abitrexate","CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",0.114,7,3,9]
["S1212","Bendamustine (SDX105) HCl","f9","L3900-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.",394.72,"3543-75-7",{"v":78,"d":"78.00"},197.61,{"v":2,"d":"2.00"},5.07,"http://selleckchem.com/products/Bendamustine-Hydrochloride.html","C16H21Cl2N3O2.HCl","Hydrochloride","Cytostasane HCl","Cl.C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCC(O)=O",3.988,2,0,9]
["S1213","Nelarabine","g9","L3900-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.",297.27,"121032-29-9",{"v":60,"d":"60.00"},201.84,{"v":3,"d":"3.00"},10.09,"http://selleckchem.com/products/Arranon.html","C11H15N5O5","free base","506U78,Arranon","COC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)N",-1.376,5,4,3]
["S1214","Bleomycin (NSC125066) sulfate","h9","L3900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Bleomycin Sulfate (Blenoxane,NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.",1512.62,"9041-93-4",{"v":100,"d":"100.00"},{"v":66,"d":"66.00"},"N/A","N/A","http://www.selleckchem.com/products/Bleomycin-sulfate.html","C55H85N17O25S4","Sulfate","Blenoxane,NSC125066","CC(O)C(NC(=O)C(C)C(O)C(C)NC(=O)C(NC(=O)C1=C(C)C(=NC(=N1)C(CC(N)=O)NCC(N)C(N)=O)N)C(OC2OC(CO)C(O)C(O)C2OC3OC(CO)C(O)C(OC(N)=O)C3O)C4=C[NH]C=N4)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C.O[S]([O-])(=O)=O","N/A","N/A","N/A","N/A"]
["S1218","Clofarabine","a10","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.",303.68,"123318-82-1",{"v":60,"d":"60.00"},197.58,"<1","N/A","http://selleckchem.com/products/Clofarabine.html","C10H11ClFN5O3","free base","Clolar","NC1=C2N=C[N](C3OC(CO)C(O)C3F)C2=NC(=N1)Cl",-0.085,4,3,2]
["S1220","OSI-930","b10","L3900-02","in 10mM DMSO","c-Kit,CSF-1R,VEGFR","Protein Tyrosine Kinase","OSI-930 is a potent inhibitor of Kit (c-Kit), KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. Phase 1.",443.44,"728033-96-3",{"v":89,"d":"89.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/OSI-930.html","C22H16F3N3O2S","free base","N/A","FC(F)(F)OC1=CC=C(NC(=O)C2=C(NCC3=CC=NC4=CC=CC=C34)C=CS2)C=C1",6.266,3,2,7]
["S1221","Dacarbazine (NSC-45388)","c10","L3900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.",182.18,"4342-03-4",{"v":12,"d":"12.00"},65.87,{"v":2,"d":"2.00"},10.98,"http://selleckchem.com/products/Dacarbazine.html","C6H10N6O","free base","DTIC-Dome, Imidazole Carboxamide,NSC-45388","CN(C)N=NC1=C(N=C[NH]1)C(N)=O",-0.344,4,2,3]
["S1222","Dexrazoxane HCl (ICRF-187)","d10","L3900-02","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Dexrazoxane HCl (ADR-529,Totect, ICRF-187, Zinecard, Cardioxane) is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent; also an inhibitor of topoisomerase II",304.73,"149003-01-0",{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},"http://selleckchem.com/products/Dexrazoxane-Hydrochloride.html","C11H16N4O4.HCl","Hydrochloride","ADR-529,Totect, ICRF-187, Zinecard, Cardioxane","Cl.CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-1.722,4,2,3]
["S1223","Epirubicin (IMI 28) HCl","e10","L3900-02","in 10mM DMSO","Apoptosis related,Topoisomerase","DNA Damage/DNA Repair","Epirubicin HCl (Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin induces apoptosis.",579.98,"56390-09-1",{"v":100,"d":"100.00"},172.42,{"v":100,"d":"100.00"},172.42,"http://selleckchem.com/products/Ellence.html","C27H29NO11.HCl","Hydrochloride","Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1225","Etoposide (VP-16)","f10","L3900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II  inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.",588.56,"33419-42-0",{"v":100,"d":"100.00"},169.91,"<1","N/A","http://selleckchem.com/products/Etopophos.html","C29H32O13","free base","VP-16213,Vepesid,VP-16","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)C6=C2C=C7OCOC7=C6",0.935,10,3,5]
["S1226","KU-0063794","g10","L3900-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.",465.54,"938440-64-3",{"v":16,"d":"16.00"},34.37,"<1","N/A","http://selleckchem.com/products/KU-0063794.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=NC(=NC(=C3C=C2)N4CCOCC4)N5CC(C)OC(C)C5",3.274,6,1,5]
["S1227","Raloxifene HCl","h10","L3900-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (LY156758, Keoxifene) HCl is a selective and orally active estrogen receptor modulator (SERM), which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.",510.04,"82640-04-8",{"v":100,"d":"100.00"},196.06,"<1","N/A","http://selleckchem.com/products/Evista.html","C28H27NO4S.HCl","Hydrochloride","LY156758 (Keoxifene) HCl","Cl.OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.843,2,2,7]
["S1229","Fludarabine Phosphate","a11","L3900-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.",365.21,"75607-67-9",{"v":73,"d":"73.00"},199.88,{"v":2,"d":"2.00"},5.48,"http://selleckchem.com/products/Fludara.html","C10H13FN5O7P","Phosphate","F-ara-A (NSC 312887) Phosphate","NC1=NC(=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O)F",-1.384,5,3,4]
["S1230","Flavopiridol (L86-8275)","b11","L3900-02","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.",401.84,"146426-40-6",{"v":15,"d":"15.00"},37.33,"<1","N/A","http://selleckchem.com/products/Flavopiridol.html","C21H20ClNO5","Free Base","NSC 649890 HCl, HMR-1275, Alvocidib","CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",3.108,2,3,2]
["S1231","Topotecan (NSC609699) HCl","c11","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,Topoisomerase","DNA Damage/DNA Repair","Topotecan HCl (Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.",457.91,"119413-54-6",{"v":91,"d":"91.00"},198.73,{"v":91,"d":"91.00"},198.73,"http://selleckchem.com/products/Topotecan-Hydrochloride.html","C23H23N3O5.HCl","Hydrochloride","Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.959,4,1,3]
["S1233","2-Methoxyestradiol (2-MeOE2)","d11","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,HIF,Microtubule Associated","Angiogenesis","2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.",302.41,"362-07-2",{"v":60,"d":"60.00"},198.41,"<1","N/A","http://selleckchem.com/products/2-Methoxyestradiol(2ME2).html","C19H26O3","free base","NSC 659853, 2-ME2","COC1=C(O)C=C2CCC3C(CCC4(C)C(O)CCC34)C2=C1",3.821,1,2,1]
["S1235","Letrozole (CGS 20267)","e11","L3900-02","in 10mM DMSO","Aromatase,Autophagy","Endocrinology & Hormones","Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.",{"v":285.3,"d":"285.30"},"112809-51-5",{"v":57,"d":"57.00"},199.79,"<1","N/A","http://selleckchem.com/products/Letrozole.html","C17H11N5","free base","CGS 20267,Femara, Piroxicam","N#CC1=CC=C(C=C1)C([N]2C=NC=N2)C3=CC=C(C=C3)C#N",2.749,2,0,3]
["S1237","Temozolomide (CCRG 81045)","f11","L3900-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.",194.15,"85622-93-1",{"v":38,"d":"38.00"},195.72,"<1","N/A","http://selleckchem.com/products/Methazolastone.html","C6H6N6O2","free base","NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal","CN1N=NC2=C(N=C[N]2C1=O)C(N)=O",0.052,5,1,1]
["S1238","Tamoxifen (ICI 46474)","g11","L3900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,ATPase,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Angiogenesis","Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.",371.51,"10540-29-1",{"v":74,"d":"74.00"},199.19,"<1","N/A","http://selleckchem.com/products/Nolvadex.html","C26H29NO","Free Base","ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1241","Vincristine (NSC-67574) sulfate","h11","L3900-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.",923.04,"2068-78-2",{"v":100,"d":"100.00"},108.34,{"v":60,"d":"60.00"},{"v":65,"d":"65.00"},"http://selleckchem.com/products/Vincristine-Sulfate.html","C46H58N4O14S","free base","Leurocristine, Oncovin, NSC-67574, 22-Oxovincaleukoblastine","CCC1(O)CC2CN(CCC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=CC6=C(C=C5OC)N(C=O)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC67C89)C(=O)OC)C1.O[S](O)(=O)=O",3.365,8,1,10]
["S1243","Agomelatine (S20098)","a2","L3900-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Agomelatine (Valdoxan, Melitor, Thymanax,S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.",{"v":243.3,"d":"243.30"},"138112-76-2",{"v":48,"d":"48.00"},197.29,"<1","N/A","http://selleckchem.com/products/Agomelatine.html","C15H17NO2","free base","Valdoxan, Melitor, Thymanax,S20098","COC1=CC2=C(CCNC(C)=O)C=CC=C2C=C1",{"v":2.17,"d":"2.170"},2,1,4]
["S1244","Amuvatinib (MP-470)","b2","L3900-03","in 10mM DMSO","Apoptosis related,c-Kit,c-Met,c-RET,FLT3,PDGFR,RAD51","Protein Tyrosine Kinase","Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.",447.51,"850879-09-3",{"v":32,"d":"32.00"},71.51,"<1","N/A","http://selleckchem.com/products/MP-470.html","C23H21N5O3S","free base","HPK 56","S=C(NCC1=CC=C2OCOC2=C1)N3CCN(CC3)C4=NC=NC5=C4OC6=CC=CC=C56",4.867,5,1,5]
["S1245","Latrepirdine 2HCl","c2","L3900-03","in 10mM DMSO","5-HT Receptor,GluR,Histamine Receptor","Neuronal Signaling","Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.",392.37,"97657-92-6",{"v":24,"d":"24.00"},61.17,"<1","N/A","http://selleckchem.com/products/Dimebon.html","C21H25N3.2HCl","Dihydrochloride","N/A","Cl.Cl.CN1CCC2=C(C1)C3=C(C=CC(=C3)C)[N]2CCC4=CC=C(C)N=C4",4.769,1,0,3]
["S1247","Leflunomide (HWA486)","d2","L3900-03","in 10mM DMSO","AhR,Dehydrogenase","Metabolism","Leflunomide (HWA486, RS-34821, SU101, Arava) is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of Leflunomide is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). Leflunomide is also an agonist of the AhR.",270.21,"75706-12-6",{"v":54,"d":"54.00"},199.84,"<1","N/A","http://selleckchem.com/products/Leflunomide.html","C12H9F3N2O2","free base","HWA486, RS-34821, SU101, Arava","CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F",2.156,3,1,3]
["S1249","JNJ-7706621","e2","L3900-03","in 10mM DMSO","Aurora Kinase,CDK","Cell Cycle","JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.",394.36,"443797-96-4",{"v":79,"d":"79.00"},200.32,"<1","N/A","http://selleckchem.com/products/JNJ-7706621.html","C15H12F2N6O3S","free base","N/A","NC1=NC(=N[N]1C(=O)C2=C(F)C=CC=C2F)NC3=CC=C(C=C3)[S](N)(=O)=O",2.226,5,3,4]
["S1250","Enzalutamide (MDV3100)","f2","L3900-03","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. Enzalutamide is shown to increase autophagy.",464.44,"915087-33-1",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/MDV3100.html","C21H16F4N4O2S","free base","MDV3100","CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC=C(C#N)C(=C3)C(F)(F)F",4.954,2,1,4]
["S1251","Dienogest","g2","L3900-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.",311.42,"65928-58-7",{"v":62,"d":"62.00"},199.09,"<1","N/A","http://selleckchem.com/products/Dienogest.html","C20H25NO2","free base","STS 557","CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC#N",3.046,1,0,1]
["S1252","Entecavir Hydrate","h2","L3900-03","in 10mM DMSO","Reverse Transcriptase","Microbiology","Entecavir Hydrate (ETV, Baraclude,BMS200475 Hydrate,SQ34676 Hydrate), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).",295.29,"209216-23-9",{"v":59,"d":"59.00"},{"v":199.8,"d":"199.80"},"<1","N/A","https://www.selleckchem.com/products/s1252-entecavir.html","C12H15N5O3.H2O","Hydrate","ETV, Baraclude,BMS200475 Hydrate,SQ34676 Hydrate","O.NC1=NC(=O)C2=C(N1)[N](C=N2)C3CC(O)C(CO)C3=C",-1.611,3,4,2]
["S1255","Nepafenac","a3","L3900-03","in 10mM DMSO","COX","Neuronal Signaling","Nepafenac (AHR 9434, AL 6515) is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.",254.28,"78281-72-8",{"v":50,"d":"50.00"},196.63,"<1","N/A","http://selleckchem.com/products/Nepafenac.html","C15H14N2O2","free base","AHR 9434, AL 6515","NC(=O)CC1=CC=CC(=C1N)C(=O)C2=CC=CC=C2",1.524,2,2,4]
["S1256","Rufinamide","b3","L3900-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Rufinamide (CGP 33101,E 2080,RUF 331,Banzel) is a voltage-gated sodium channel blocker, used an anticonvulsant medication.",238.19,"106308-44-5",{"v":18,"d":"18.00"},75.57,"<1","N/A","http://selleckchem.com/products/Rufinamide.html","C10H8F2N4O","free base","CGP 33101,E 2080,RUF 331,Banzel","NC(=O)C1=C[N](CC2=C(F)C=CC=C2F)N=N1",1.437,3,1,3]
["S1257","Posaconazole (SCH 56592)","c3","L3900-03","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Posaconazole (SCH 56592,POS,Noxafil) is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.",700.78,"171228-49-2",{"v":100,"d":"100.00"},{"v":142.7,"d":"142.70"},"<1","N/A","http://selleckchem.com/products/Posaconazole.html","C37H42F2N8O4","free base","SCH 56592,POS,Noxafil","CCC(C(C)O)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C5)(C[N]6C=NC=N6)C7=CC=C(F)C=C7F)C=C4",5.096,6,1,12]
["S1258","Prasugrel","d3","L3900-03","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Prasugrel (Effient, Efient, Prasita,CS-747, LY640315,PCR 4099) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.",373.44,"150322-43-3",{"v":30,"d":"30.00"},80.33,"<1","N/A","http://selleckchem.com/products/Prasugrel.html","C20H20FNO3S","Free Base","Effient, Efient, Prasita,CS-747, LY640315,PCR 4099","CC(=O)OC1=CC2=C(CCN(C2)C(C(=O)C3CC3)C4=CC=CC=C4F)S1",3.801,3,0,6]
["S1259","Ramelteon","e3","L3900-03","in 10mM DMSO","MT Receptor","GPCR & G Protein","Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.",259.34,"196597-26-9",{"v":52,"d":"52.00"},200.51,"<1","N/A","http://selleckchem.com/products/Ramelteon.html","C16H21NO2","free base","TAK-375","CCC(=O)NCCC1CCC2=CC=C3OCCC3=C12",2.826,2,1,4]
["S1260","Cinacalcet (AMG-073) HCl","f3","L3900-03","in 10mM DMSO","CaSR","GPCR & G Protein","Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.",393.87,"364782-34-3",{"v":79,"d":"79.00"},200.57,"<1","N/A","http://selleckchem.com/products/Cinacalcet-hydrochloride.html","C22H22F3N.HCl","Hydrochloride","Mimpara, Sensipar,AMG-073","Cl.CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=C2C=CC=C3",6.338,0,1,7]
["S1261","Celecoxib (SC 58635)","g3","L3900-03","in 10mM DMSO","COX","Neuronal Signaling","Celecoxib (Celebrex, Celebra,SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.",381.37,"169590-42-5",{"v":76,"d":"76.00"},199.28,"<1","N/A","http://selleckchem.com/products/Celecoxib.html","C17H14F3N3O2S","free base","Celebrex, Celebra,SC 58635","CC1=CC=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)(F)F",4.428,3,1,4]
["S1262","Avagacestat (BMS-708163)","h3","L3900-03","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.",520.88,"1146699-66-2",{"v":104,"d":"104.00"},199.66,"<1","N/A","http://selleckchem.com/products/BMS-708163.html","C20H17ClF4N4O4S","free base","N/A","NC(=O)C(CCC(F)(F)F)N(CC1=C(F)C=C(C=C1)C2=NOC=N2)[S](=O)(=O)C3=CC=C(Cl)C=C3",3.364,6,1,10]
["S1263","Laduviglusib (CHIR-99021)","a4","L3900-03","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.",465.34,"252917-06-9",{"v":10,"d":"10.00"},21.49,"<1","N/A","http://selleckchem.com/products/CHIR-99021.html","C22H18Cl2N8","free base","CT99021","CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=CC=C(C=N3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.476,4,3,7]
["S1264","PD173074","b4","L3900-03","in 10mM DMSO","Apoptosis related,FGFR,VEGFR","Angiogenesis","PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.",523.67,"219580-11-7",{"v":100,"d":"100.00"},190.96,"<1","N/A","http://selleckchem.com/products/PD-173074.html","C28H41N7O3","free base","N/A","CCN(CC)CCCCNC1=NC=C2C=C(C(=NC2=N1)NC(=O)NC(C)(C)C)C3=CC(=CC(=C3)OC)OC",4.313,6,3,13]
["S1267","Vemurafenib (PLX4032)","c4","L3900-03","in 10mM DMSO","Autophagy,Raf","MAPK","Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.",489.92,"918504-65-1",{"v":97,"d":"97.00"},197.99,"<1","N/A","http://selleckchem.com/products/PLX-4032.html","C23H18ClF2N3O3S","free base","RG7204, RO5185426,PLX4032","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CC=C(Cl)C=C4",4.953,4,2,7]
["S1271","Acarbose","d4","L3900-03","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.",{"v":645.6,"d":"645.60"},"56180-94-0",{"v":100,"d":"100.00"},154.89,{"v":100,"d":"100.00"},154.89,"http://selleckchem.com/products/Acarbose.html","C25H43NO18","free base","BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421","CC1OC(OC2C(O)C(O)C(OC2CO)OC3C(O)C(O)C(O)OC3CO)C(O)C(O)C1NC4C=C(CO)C(O)C(O)C4O",-6.839,5,13,9]
["S1274","BX-795","e4","L3900-03","in 10mM DMSO","Autophagy,IκB/IKK,PDPK1,TBK1","PI3K/Akt/mTOR","BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.",591.47,"702675-74-9",{"v":100,"d":"100.00"},169.07,"<1","N/A","http://selleckchem.com/products/bx-795.html","C23H26IN7O2S","free base","N/A","IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4",3.704,4,4,9]
["S1275","BX-912","f4","L3900-03","in 10mM DMSO","PDK","PI3K/Akt/mTOR","BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.",471.35,"702674-56-4",{"v":94,"d":"94.00"},199.43,"<1","N/A","http://selleckchem.com/products/bx-912.html","C20H23BrN8O","free base","N/A","BrC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCC4=CN=C[NH]4",2.798,4,4,7]
["S1276","Adapalene","g4","L3900-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.",412.52,"106685-40-9",{"v":8,"d":"8.00"},19.39,"<1","N/A","http://selleckchem.com/products/Adapalene.html","C28H28O3","free base","CD-271","COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(O)=O)[C]45CC6[CH2][CH](C[CH]([CH2]6)C4)C5",6.279,2,0,4]
["S1278","Altretamine","h4","L3900-03","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.",210.28,"645-05-6",{"v":15,"d":"15.00"},71.33,"<1","N/A","http://selleckchem.com/products/Altretamine.html","C9H18N6","free base","Hexamethylmelamine, NSC13875, ENT50852","CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C",1.995,3,0,3]
["S1280","Amisulpride","a5","L3900-03","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.",369.48,"71675-85-9",{"v":73,"d":"73.00"},197.57,"<1","N/A","http://selleckchem.com/products/Amisulpride.html","C17H27N3O4S","free base","DAN-2163","CCN1CCCC1CNC(=O)C2=CC(=C(N)C=C2OC)[S](=O)(=O)CC",1.127,4,2,7]
["S1281","Aniracetam","b5","L3900-03","in 10mM DMSO","AMPA Receptor-kainate Receptor-NMDA Receptor","Neuronal Signaling","Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug.",219.24,"72432-10-1",{"v":44,"d":"44.00"},200.69,"<1","N/A","http://selleckchem.com/products/Aniracetam.html","C12H13NO3","free base","RO 13-5057","COC1=CC=C(C=C1)C(=O)N2CCCC2=O",1.267,3,0,2]
["S1282","Artemisinin","c5","L3900-03","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.",282.33,"63968-64-9",{"v":57,"d":"57.00"},201.89,"<1","N/A","http://selleckchem.com/products/Artemisinin.html","C15H22O5","free base","Qinghaosu,Artemisinine,Coartem,NSC 369397","CC1CCC2C(C)C(=O)OC3OC4(C)CCC1C23OO4",1.998,5,0,0]
["S1283","Asenapine maleate","d5","L3900-03","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor","Neuronal Signaling","Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.",401.84,"85650-56-2",{"v":80,"d":"80.00"},199.08,"<1","N/A","http://selleckchem.com/products/Asenapine.html","C17H16ClNO.C4H4O4","Maleate","Org 5222","CN1CC2C(C1)C3=C(OC4=C2C=CC=C4)C=CC(=C3)Cl.OC(=O)\\C=C/C(O)=O",0.883,3,0,2]
["S1284","Benazepril HCl","e5","L3900-03","in 10mM DMSO","RAAS","Endocrinology & Hormones","Benazepril HCl (CGS 14824A) is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.",460.95,"86541-74-4",{"v":92,"d":"92.00"},199.59,{"v":19,"d":"19.00"},41.22,"http://selleckchem.com/products/Benazepril-hydrochloride.html","C24H28N2O5.HCl","Hydrochloride","CGS 14824A HCl","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=C(C=CC=C3)N(CC(O)=O)C2=O",1.003,4,1,10]
["S1286","Budesonide","f5","L3900-03","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Budesonide(Labazenit) is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.",430.53,"51333-22-3",{"v":86,"d":"86.00"},199.75,"<1","N/A","http://selleckchem.com/products/Budesonide.html","C25H34O6","free base","Labazenit","CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(O1)C(=O)CO",2.198,4,2,4]
["S1287","Bumetanide","g5","L3900-03","in 10mM DMSO","NKCC","Transmembrane Transporters","Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.",364.42,"28395-03-1",{"v":73,"d":"73.00"},200.32,"<1","N/A","http://selleckchem.com/products/Bumetanide.html","C17H20N2O5S","free base","N/A","CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)[S](N)(=O)=O",2.862,4,2,8]
["S1290","Celastrol (NSC 70931)","h5","L3900-03","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1291","Cetirizine DiHCl","a6","L3900-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cetirizine DiHCl (Zyrtec, Reactine,UCB P071) is an antihistamine.",461.81,"83881-52-1",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/Cetirizine-Dihydrochloride.html","C21H25ClN2O3.2HCl","Dihydrochloride","Zyrtec, Reactine,UCB P071","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S1292","Chelerythrine Chloride (NSC 646662)","b6","L3900-03","in 10mM DMSO","PKC","TGF-beta/Smad","Chelerythrine Chloride (NSC 646662, Broussonpapyrine) is a potent, selective antagonist of PKC with IC50 of 0.66 μM.",384.83,"3895-92-9",{"v":4,"d":"4.00"},10.39,"<1","N/A","http://www.selleck.cn/products/Chelerythrine-chloride.html","C21H18NO4.HCl","Chloride","Broussonpapyrine chloride","Cl.COC1=CC=C2C(=C1OC)C=[N+](C)C3=C2C=CC4=C3C=C5OCOC5=C4",4.568,4,0,2]
["S1293","Cilnidipine (FRC-8653)","c6","L3900-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cilnidipine (FRC-8653) is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.",492.52,"132203-70-4",{"v":99,"d":"99.00"},201.01,"<1","N/A","http://selleckchem.com/products/Cilnidipine.html","C27H28N2O7","free base","FRC-8653","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC\\C=C\\C3=CC=CC=C3)C",3.686,5,1,12]
["S1294","Cilostazol (OPC-13013)","d6","L3900-03","in 10mM DMSO","PDE","Metabolism","Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.",369.46,"73963-72-1",{"v":74,"d":"74.00"},200.29,"<1","N/A","http://selleckchem.com/products/Cilostazol.html","C20H27N5O2","free base","Pletal,OPC-13013","O=C1CCC2=C(N1)C=CC(=C2)OCCCCC3=NN=N[N]3C4CCCCC4",{"v":3.23,"d":"3.230"},5,1,7]
["S1297","Epothilone A","e6","L3900-03","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.",493.66,"152044-53-6",{"v":99,"d":"99.00"},200.54,"<1","N/A","http://selleckchem.com/products/Epothilone-A.html","C26H39NO6S","free base","N/A","CC1CCCC2OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.574,5,2,2]
["S1299","Floxuridine (NSC 27640)","f6","L3900-03","in 10mM DMSO","Apoptosis related,CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.",246.19,"50-91-9",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/Floxuridine.html","C9H11FN2O5","free base","Deoxyfluorouridine, FUDR,NSC 27640","OCC1OC(CC1O)N2C=C(F)C(=O)NC2=O",-1.775,3,3,2]
["S1300","Tegafur (FT-207)","g6","L3900-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.",200.17,"17902-23-7",{"v":40,"d":"40.00"},199.83,{"v":8,"d":"8.00"},39.97,"http://selleckchem.com/products/Ftorafur.html","C8H9FN2O3","free base","NSC 148958,Fluorafur,FT-207","FC1=CN(C2CCCO2)C(=O)NC1=O",-0.625,3,1,1]
["S1302","Ifosfamide (NSC109724)","h6","L3900-03","in 10mM DMSO","DNA alkylator,DNA/RNA Synthesis","DNA Damage/DNA Repair","Ifosfamide (Mitoxana, Ifex,Isophosphamide,NSC109724) is a nitrogen mustard alkylating agent used in the treatment of cancer.",261.09,"3778-73-2",{"v":52,"d":"52.00"},199.17,{"v":52,"d":"52.00"},199.17,"http://selleckchem.com/products/Ifosfamide.html","C7H15Cl2N2O2P","free base","Mitoxana, Ifex,Isophosphamide,NSC109724","ClCCN[P]1(=O)OCCCN1CCCl",0.144,2,1,5]
["S1304","Megestrol Acetate","a7","L3900-03","in 10mM DMSO","Androgen Receptor,Estrogen/progestogen Receptor","Endocrinology & Hormones","Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.",384.51,"595-33-5",{"v":33,"d":"33.00"},85.82,"<1","N/A","http://selleckchem.com/products/Megestrol-Acetate.html","C24H32O4","free base","BDH1298, SC10363","CC(=O)OC1(CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C)C(C)=O",3.505,4,0,3]
["S1305","Mercaptopurine (6-MP)","b7","L3900-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",152.18,"50-44-2",{"v":30,"d":"30.00"},197.13,"<1","N/A","http://selleckchem.com/products/Mercaptopurine.html","C5H4N4S","free base","6-MP","S=C1N=CNC2=C1[NH]C=N2",0.367,2,2,0]
["S1315","Ki16425","c7","L3900-03","in 10mM DMSO","LPA Receptor","GPCR & G Protein","Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively, shows no activity at LPA4, LPA5, LPA6.",474.96,"355025-24-0",{"v":94,"d":"94.00"},197.91,"<1","N/A","http://selleckchem.com/products/Ki16425.html","C23H23ClN2O5S","free base","N/A","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(CSCCC(O)=O)C=C2)C3=C(Cl)C=CC=C3",5.043,5,1,10]
["S1322","Dexamethasone (MK-125)","d7","L3900-03","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1324","Doxazosin Mesylate","e7","L3900-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.",547.58,"77883-43-3",{"v":15,"d":"15.00"},27.39,"<1","N/A","http://selleckchem.com/products/Doxazosin-mesylate.html","C23H25N5O5.CH4O3S","Mesylate","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCN(CC3)C(=O)C4COC5=C(O4)C=CC=C5)N.C[S](O)(=O)=O",2.071,7,1,4]
["S1326","Edaravone","f7","L3900-03","in 10mM DMSO","Antioxidant","ER stress & UPR","Edaravone (MCI-186) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke.",{"v":174.2,"d":"174.20"},"89-25-8",{"v":35,"d":"35.00"},200.92,"<1","N/A","http://selleckchem.com/products/Edaravone.html","C10H10N2O","free base","MCI-186","CC1=NN(C(=O)C1)C2=CC=CC=C2",1.123,2,0,1]
["S1328","Etodolac","g7","L3900-03","in 10mM DMSO","COX","Neuronal Signaling","Etodolac(AY-24236) is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.",287.35,"41340-25-4",{"v":58,"d":"58.00"},201.84,"<1","N/A","http://selleckchem.com/products/Etodolac.html","C17H21NO3","free base","AY-24236","CCC1=CC=CC2=C1[NH]C3=C2CCOC3(CC)CC(O)=O",3.723,2,1,4]
["S1330","Felbamate","h7","L3900-03","in 10mM DMSO","NMDAR","Neuronal Signaling","Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.",238.24,"25451-15-4",{"v":48,"d":"48.00"},201.48,"<1","N/A","http://selleckchem.com/products/Felbamate.html","C11H14N2O4","free base","Felbatol, ADD-03055,W-554","NC(=O)OCC(COC(N)=O)C1=CC=CC=C1",0.984,4,2,7]
["S1331","Fluconazole (UK 49858)","a8","L3900-03","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Fluconazole (Diflucan, Trican, Alfumet,UK 49858) is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.",306.27,"86386-73-4",{"v":61,"d":"61.00"},199.17,"<1","N/A","http://selleckchem.com/products/Fluconazole.html","C13H12F2N6O","free base","Diflucan, Trican, Alfumet,UK 49858","OC(C[N]1C=NC=N1)(C[N]2C=NC=N2)C3=C(F)C=C(F)C=C3",{"v":0.75,"d":"0.750"},4,0,5]
["S1332","Flumazenil (RO 15-1788)","b8","L3900-03","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.",303.29,"78755-81-4",{"v":5,"d":"5.00"},16.49,"<1","N/A","http://selleckchem.com/products/Flumazenil.html","C15H14FN3O3","free base","RO 15-1788","CCOC(=O)C1=C2CN(C)C(=O)C3=CC(=CC=C3[N]2C=N1)F",1.583,4,0,3]
["S1333","Fluoxetine (Lilly 110140) HCl","c8","L3900-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.",345.79,"56296-78-7",{"v":69,"d":"69.00"},199.54,{"v":4,"d":"4.00"},11.57,"http://selleckchem.com/products/Fluoxetine-hydrochloride.html","C17H18F3NO.HCl","Hydrochloride","Prozac, Sarafem,LY-110140","Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2",4.415,1,1,7]
["S1334","Flupirtine maleate","d8","L3900-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.",420.39,"75507-68-5",{"v":84,"d":"84.00"},199.81,"<1","N/A","http://selleckchem.com/products/Flupirtine-maleate.html","C15H17FN4O2.C4H4O4","Maleate","N/A","CCOC(=O)NC1=C(N)N=C(NCC2=CC=C(F)C=C2)C=C1.OC(=O)\\C=C\\C(O)=O",{"v":2.76,"d":"2.760"},5,3,8]
["S1336","Fluvoxamine (DU-23000) maleate","e8","L3900-03","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Fluvoxamine maleate (DU-23000, MK-264) is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.",434.41,"61718-82-9",{"v":87,"d":"87.00"},200.27,"<1","N/A","http://selleckchem.com/products/Fluvoxamine-maleate.html","C19H25F3N2O6","Maleate","MK-264,DU-23000 maleate","COCCCCC(=N\\OCCN)/C1=CC=C(C=C1)C(F)(F)F.OC(=O)\\C=C/C(O)=O",0.111,5,1,12]
["S1340","Gatifloxacin","f8","L3900-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Gatifloxacin (AM-1155, CG5501, BMS-206584) is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.",375.39,"112811-59-3",{"v":7,"d":"7.00"},18.65,"<1","N/A","http://selleckchem.com/products/Gatifloxacin.html","C19H22FN3O4","free base","AM-1155, CG5501, BMS-206584","COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CCNC(C)C3)F)C4CC4",-0.909,3,1,4]
["S1342","Genistein (NPI 031L)","g8","L3900-03","in 10mM DMSO","EGFR,Topoisomerase","Protein Tyrosine Kinase","Genistein (NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK)  which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.",270.24,"446-72-0",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Genistein.html","C15H10O5","free base","NPI 031L","OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O",{"v":2.14,"d":"2.140"},2,3,1]
["S1343","Ginkgolide B","h8","L3900-03","in 10mM DMSO","PAFR","GPCR & G Protein","Ginkgolide B (BN52021) is a PAFR antagonist with IC50 of 3.6 μM.",{"v":424.4,"d":"424.40"},"15291-77-7",{"v":85,"d":"85.00"},200.28,"<1","N/A","http://selleckchem.com/products/Ginkgolide-B.html","C20H24O10","free base","BN52021","CC1C(=O)OC2C(O)C34C5CC(C(C)(C)C)C36C(O)C(=O)OC6OC4(C(=O)O5)C12O",-0.854,7,2,1]
["S1344","Glimepiride","a9","L3900-03","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glimepiride(HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.",490.62,"93479-97-1",{"v":11,"d":"11.00"},22.42,"<1","N/A","http://selleckchem.com/products/Glimepiride.html","C24H34N4O5S","free base","HOE-490","CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCC(C)CC3)C1=O",3.781,5,3,7]
["S1351","Ivermectin (MK-933)","b9","L3900-03","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1","N/A","http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1352","TG100-115","c9","L3900-03","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.",346.34,"677297-51-7",{"v":9,"d":"9.00"},25.99,"<1","N/A","http://selleckchem.com/products/TG100-115.html","C18H14N6O2","free base","N/A","NC1=NC2=NC(=C(N=C2C(=N1)N)C3=CC(=CC=C3)O)C4=CC=CC(=C4)O",2.687,4,4,2]
["S1354","Lansoprazole","d9","L3900-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.",369.36,"103577-45-3",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/Lansoprazole.html","C16H14F3N3O2S","free base","A-65006, AG-1749","CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2",3.442,4,1,6]
["S1356","Levetiracetam (UCB-L059)","e9","L3900-03","in 10mM DMSO","AChR,Calcium Channel","Transmembrane Transporters","Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.",170.21,"102767-28-2",{"v":34,"d":"34.00"},199.75,{"v":34,"d":"34.00"},199.75,"http://selleckchem.com/products/Levetiracetam.html","C8H14N2O2","free base","UCB-L059, SIB-S1","CCC(N1CCCC1=O)C(N)=O",-0.304,2,1,3]
["S1357","Lidocaine","f9","L3900-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.",234.34,"137-58-6",{"v":47,"d":"47.00"},200.56,{"v":9,"d":"9.00"},38.41,"http://selleckchem.com/products/Lidocaine.html","C14H22N2O","Free Base","Alphacaine","CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",2.626,1,1,5]
["S1358","Loratadine (SCH29851)","g9","L3900-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Loratadine (Alavert,Claritin,SCH29851) is a histamine H1 receptor antagonist, used to treat allergies. Also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 μM.",382.88,"79794-75-5",{"v":17,"d":"17.00"},{"v":44.4,"d":"44.40"},"<1","N/A","http://selleckchem.com/products/Loratadine.html","C22H23ClN2O2","free base","Alavert,Claritin,SCH29851","CCOC(=O)N1CCC(CC1)=C2C3=C(CCC4=C2N=CC=C4)C=C(Cl)C=C3",{"v":5,"d":"5.000"},3,0,2]
["S1359","Losartan Potassium (DuP 753)","h9","L3900-03","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.",462.01,"124750-99-8",{"v":92,"d":"92.00"},199.13,{"v":92,"d":"92.00"},199.13,"http://selleckchem.com/products/losartan-potassium.html","C22H23ClKN6O","Potassium salt","MK 954,DuP 753","[KH].CCCCC1=NC(=C(CO)[N]1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4)Cl",4.241,4,2,8]
["S1361","MGCD-265 analog","a10","L3900-03","in 10mM DMSO","c-Met,RON,Tie-2,VEGFR","Protein Tyrosine Kinase","MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively; also inhibits Ron and Tie2. Phase 1/2.",{"v":517.6,"d":"517.60"},"875337-44-3",{"v":104,"d":"104.00"},200.93,"<1","N/A","https://www.selleckchem.com/products/mgcd-265-analog.html","C26H20FN5O2S2","free base","N/A","C[N]1C=NC(=C1)C2=CC3=NC=CC(=C3S2)OC4=CC=C(NC(=S)NC(=O)CC5=CC=CC=C5)C=C4F",6.037,4,2,8]
["S1362","Rigosertib (ON-01910)","b10","L3900-03","in 10mM DMSO","Akt,Apoptosis related,PI3K,PLK","Cell Cycle","Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.",473.47,"1225497-78-8",{"v":95,"d":"95.00"},200.65,{"v":95,"d":"95.00"},200.65,"http://selleckchem.com/products/ON-01910.html","C21H24NNaO8S","Sodium Salt","N/A","[Na+].COC1=CC(=C(\\C=C\\[S](=O)(=O)CC2=CC=C(OC)C(=C2)NCC([O-])=O)C(=C1)OC)OC",0.632,6,1,11]
["S1364","Patupilone (Epothilone B)","c10","L3900-03","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.",507.68,"152044-54-7",{"v":102,"d":"102.00"},200.91,"<1","N/A","http://selleckchem.com/products/Epothilone-B.html","C27H41NO6S","free base","EPO906","CC1CCCC2(C)OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.779,5,2,2]
["S1366","BMS-707035","d10","L3900-03","in 10mM DMSO","Integrase","Microbiology","BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.",410.42,"729607-74-3",{"v":38,"d":"38.00"},92.59,"<1","N/A","http://selleckchem.com/products/BMS-707035.html","C17H19FN4O5S","free base","N/A","CN1C(=O)C(=C(N=C1N2CCCC[S]2(=O)=O)C(=O)NCC3=CC=C(F)C=C3)O",0.385,5,2,4]
["S1367","Amonafide","e10","L3900-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.",283.33,"69408-81-7",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://selleckchem.com/products/Amonafide.html","C16H17N3O2","free base","NSC308847,AS1413","CN(C)CCN1C(=O)C2=C3C(=CC=C2)C=C(N)C=C3C1=O",1.162,2,1,3]
["S1368","Acitretin","f10","L3900-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.",326.43,"55079-83-9",{"v":20,"d":"20.00"},61.27,"<1","N/A","http://selleckchem.com/products/Acitretin.html","C21H26O3","free base","Etretin, RO 10-1670","COC1=CC(=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(=C1C)C)C",5.665,2,0,6]
["S1369","Bafetinib (INNO-406)","g10","L3900-03","in 10mM DMSO","Bcr-Abl","Angiogenesis","Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.",576.62,"859212-16-1",{"v":100,"d":"100.00"},173.42,"<1","N/A","http://selleckchem.com/products/Bafetinib.html","C30H31F3N8O","free base","NS-187","CN(C)C1CCN(C1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CN=C5",4.197,5,2,9]
["S1373","Daptomycin (LY146032)","h10","L3900-03","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Bacterial,DNA/RNA Synthesis","DNA Damage/DNA Repair","Daptomycin (Cubicin,LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.",1620.67,"103060-53-3",{"v":100,"d":"100.00"},{"v":61.7,"d":"61.70"},{"v":100,"d":"100.00"},{"v":61.7,"d":"61.70"},"http://selleckchem.com/products/Daptomycin.html","C72H101N17O26","free base","Cubicin,LY146032","CCCCCCCCCC(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC3C(C)OC(=O)C(CC(=O)C4=CC=CC=C4N)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCN)NC(=O)CNC3=O)C(C)CC(O)=O",-7.895,21,18,35]
["S1374","Doripenem Hydrate","a11","L3900-03","in 10mM DMSO","Antibiotics","Microbiology","Doripenem Hydrate (S-4661) is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections.",438.52,"364622-82-2",{"v":36,"d":"36.00"},82.09,{"v":26,"d":"26.00"},59.29,"http://selleckchem.com/products/Doripenem-Hydrate.html","C15H24N4O6S2.H2O","Hydrate","S-4661","O.CC(O)C1C2C(C)C(=C(N2C1=O)C(O)=O)SC3CNC(CN[S](N)(=O)=O)C3",-5.546,4,4,7]
["S1376","Gestodene","b11","L3900-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Gestodene (SH B 331,WL 70) is a progestogen hormonal contraceptive.",310.43,"60282-87-3",{"v":62,"d":"62.00"},199.72,"<1","N/A","http://selleckchem.com/products/Gestodene.html","C21H26O2","free base","SH B 331,WL 70","CCC12CCC3C(CCC4=CC(=O)CCC34)C1C=CC2(O)C#C",4.462,1,0,1]
["S1377","Drospirenone","c11","L3900-03","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.",366.49,"67392-87-4",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/Drospirenone.html","C24H30O3","free base","ZK 3059","CC12CCC(=O)C=C1C3CC3C4C2CCC5(C)C4C6CC6C57CCC(=O)O7",3.383,3,0,0]
["S1378","Ruxolitinib (INCB018424)","d11","L3900-03","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",306.37,"941678-49-5",{"v":61,"d":"61.00"},199.11,"<1","N/A","http://selleckchem.com/products/INCB18424.html","C17H18N6","free base","INCB018424","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S1379","Isotretinoin","e11","L3900-03","in 10mM DMSO","Hydroxylase","Metabolism","Isotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.",300.44,"4759-48-2",{"v":60,"d":"60.00"},199.71,"<1","N/A","http://selleckchem.com/products/Isotretinoin.html","C20H28O2","free base","13-cis retinoic acid","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C/C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1380","Lopinavir (ABT-378)","f11","L3900-03","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.",{"v":628.8,"d":"628.80"},"192725-17-0",{"v":126,"d":"126.00"},200.38,"<1","N/A","http://selleckchem.com/products/Lopinavir.html","C37H48N4O5","free base","ABT-378","CC(C)C(N1CCCNC1=O)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)COC3=C(C)C=CC=C3C)CC4=CC=CC=C4",4.926,4,4,15]
["S1381","Meropenem","g11","L3900-03","in 10mM DMSO","Antibiotics","Microbiology","Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.",383.46,"96036-03-2",{"v":76,"d":"76.00"},{"v":198.2,"d":"198.20"},{"v":8,"d":"8.00"},20.86,"http://selleckchem.com/products/Meropenem.html","C17H25N3O5S","free base","SM 7338","CC(O)C1C2C(C)C(=C(N2C1=O)C(O)=O)SC3CNC(C3)C(=O)N(C)C",-4.129,3,2,5]
["S1382","Mianserin HCl","h11","L3900-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Mianserin (Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.",300.83,"21535-47-7",{"v":60,"d":"60.00"},199.45,{"v":30,"d":"30.00"},99.72,"http://selleckchem.com/products/mianserin-hydrochloride.html","C18H20N2.HCl","Hydrochloride","Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride","Cl.CN1CCN2C(C1)C3=C(CC4=C2C=CC=C4)C=CC=C3",4.088,0,0,0]
["S1386","Nafamostat mesilate (FUT-175)","a2","L3900-04","in 10mM DMSO","Apoptosis related,COVID-19,SARS-CoV,Serine Protease","Proteases","Nafamostat mesilate (Futhan, FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.",539.58,"82956-11-4",{"v":20,"d":"20.00"},37.07,{"v":53,"d":"53.00"},98.22,"http://selleckchem.com/products/Nafamostat-mesylate.html","C19H17N5O2.2CH4O3S","Dimesylate","Futhan, FUT-175","C[S](O)(=O)=O.C[S](O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(N)=N",1.364,2,3,6]
["S1387","Naftopidil DiHCl","b2","L3900-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Naftopidil DiHCl (Flivas, KT-611, Avishot,BM-15275) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.",465.41,"57149-08-3",{"v":41,"d":"41.00"},88.09,"<1","N/A","http://selleckchem.com/products/Naftopidil-Dihydrochloride.html","C24H28N2O3.2HCl","Dihydrochloride","Flivas, KT-611, Avishot,BM-15275","Cl.Cl.COC1=CC=CC=C1N2CCN(CC2)CC(O)COC3=C4C=CC=CC4=CC=C3",4.726,2,1,7]
["S1389","Omeprazole","c2","L3900-04","in 10mM DMSO","ATPase,Autophagy,Proton Pump","Transmembrane Transporters","Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.",345.42,"73590-58-6",{"v":69,"d":"69.00"},199.76,"<1","N/A","http://selleckchem.com/products/Omeprazole.html","C17H19N3O3S","free base","N/A","COC1=CC=C2[NH]C(=NC2=C1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.904,5,1,5]
["S1390","Ondansetron HCl","d2","L3900-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ondansetron HCl (Ondemet, Emeset, Emetron,GR 38032F,SN 307) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.",329.82,"99614-01-4",{"v":66,"d":"66.00"},200.11,{"v":24,"d":"24.00"},72.77,"http://selleckchem.com/products/Ondansetron-hydrochloride.html","C18H19N3O.HCl","Hydrochloride","Ondemet, Emeset, Emetron,GR 38032F,SN 307","Cl.C[N]1C2=C(C(=O)C(CC2)C[N]3C=CN=C3C)C4=CC=CC=C14",3.016,2,0,2]
["S1391","Oxcarbazepine","e2","L3900-04","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.",252.27,"28721-07-5",{"v":7,"d":"7.00"},27.75,"<1","N/A","http://selleckchem.com/products/Oxcarbazepine.html","C15H12N2O2","free base","GP47680","NC(=O)N1C2=C(CC(=O)C3=C1C=CC=C3)C=CC=C2",2.131,2,1,0]
["S1392","Pelitinib (EKB-569)","f2","L3900-04","in 10mM DMSO","EGFR,MEK,Src","Protein Tyrosine Kinase","Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Pelitinib (EKB-569) also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282 nM, 800 nM and 1255 nM, respectively. Phase2.",467.92,"257933-82-7",{"v":13,"d":"13.00"},27.78,"<1","N/A","http://selleckchem.com/products/Pelitinib.html","C24H23ClFN5O2","free base","N/A","CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(=C2NC3=CC(=C(F)C=C3)Cl)C#N",4.455,3,2,8]
["S1393","Pirarubicin (NSC-333054)","g2","L3900-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Pirarubicin (NSC-333054,THP) is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.",627.64,"72496-41-4",{"v":7,"d":"7.00"},11.15,"<1","N/A","http://selleckchem.com/products/Pirarubicin.html","C32H37NO12","free base","NSC-333054,THP","COC1=CC=CC2=C1C(=O)C3=C(O)C4=C(CC(O)(CC4OC5CC(N)C(OC6CCCCO6)C(C)O5)C(=O)CO)C(=C3C2=O)O",1.091,8,4,7]
["S1394","Pizotifen Malate","h2","L3900-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Pizotifen Malate (Sandomigran, pizotyline,BC-105) is a benzocycloheptane based agent used for recurrent migraine headaches.",429.53,"5189-11-7",{"v":21,"d":"21.00"},48.89,"<1","N/A","http://selleckchem.com/products/Pizotifen-malate.html","C19H21NS.C4H6O5","Malate","Sandomigran, pizotyline,BC-105","CN1CCC(CC1)=C2C3=C(CCC4=C2C=CC=C4)SC=C3.OC(CC(O)=O)C(O)=O",0.292,2,1,3]
["S1396","Resveratrol (SRT501)","a3","L3900-04","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1","N/A","http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1397","Rocuronium Bromide","b3","L3900-04","in 10mM DMSO","AChR","Neuronal Signaling","Rocuronium Bromide (ORG 9426) is a competitive AchR antagonist, used in modern anaesthesia.",609.68,"119302-91-9",{"v":122,"d":"122.00"},{"v":200.1,"d":"200.10"},{"v":122,"d":"122.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Rocuronium-bromide.html","C32H53N2O4.Br","Bromide","ORG 9426","[Br-].CC(=O)OC1C(CC2C3CCC4CC(O)C(CC4(C)C3CCC12C)N5CCOCC5)[N+]6(CCCC6)CC=C",0.282,3,1,6]
["S1398","Stavudine (d4T)","c3","L3900-04","in 10mM DMSO","Reverse Transcriptase","Microbiology","Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.",224.21,"3056-17-5",{"v":45,"d":"45.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/Stavudine.html","C10H12N2O4","free base","BMY-27857, Sanilvudine, NSC 163661,d4T","CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O",-0.515,3,2,2]
["S1400","Tenofovir (GS 1278) Disoproxil Fumarate","d3","L3900-04","in 10mM DMSO","HIV,Reverse Transcriptase","Microbiology","Tenofovir Disoproxil Fumarate (Tenofovir DF,GS-1278 Disoproxil Fumarate) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.",635.51,"202138-50-9",{"v":100,"d":"100.00"},157.35,"<1","N/A","http://selleckchem.com/products/Tenofovir-Disoproxil-Fumarate.html","C19H30N5O10P.C4H4O4","Fumarate","Tenofovir DF,GS-1278 Disoproxil Fumarate","CC(C)OC(=O)OCO[P](=O)(COC(C)C[N]1C=NC2=C1N=CN=C2N)OCOC(=O)OC(C)C.OC(=O)/C=C/C(O)=O",1.729,14,1,19]
["S1401","Tenofovir","e3","L3900-04","in 10mM DMSO","Antiviral,COVID-19,Reverse Transcriptase","Microbiology","Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.",287.21,"147127-20-6",{"v":4,"d":"4.00"},13.93,{"v":2,"d":"2.00"},6.96,"http://selleckchem.com/products/Tenofovir.html","C9H14N5O4P","free base","GS-1278","CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O",-0.772,4,1,5]
["S1403","Tigecycline (GAR-936)","f3","L3900-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Bacterial","Microbiology","Tigecycline (Tygacil, GAR-936, WAY-GAR-936, TBG-MINO) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline induces autophagy by downregulating the PI3K-AKT-mTOR pathway.",585.65,"220620-09-7",{"v":100,"d":"100.00"},170.75,{"v":100,"d":"100.00"},170.75,"http://selleckchem.com/products/Tigecycline.html","C29H39N5O8","free base","Tygacil, GAR-936, WAY-GAR-936, TBG-MINO","CN(C)C1C2CC3CC4=C(C(=C(NC(=O)CNC(C)(C)C)C=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",-0.381,4,6,7]
["S1404","Trilostane","g3","L3900-04","in 10mM DMSO","Dehydrogenase","Metabolism","Trilostane (WIN 24540) is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.",329.43,"13647-35-3",{"v":65,"d":"65.00"},197.31,"<1","N/A","http://selleckchem.com/products/Trilostane.html","C20H27NO3","free base","WIN 24540","CC12CCC3C(CCC45OC4C(=C(CC35C)C#N)O)C1CCC2O",2.434,1,2,0]
["S1405","Vecuronium Bromide","h3","L3900-04","in 10mM DMSO","AChR","Neuronal Signaling","Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.",637.73,"50700-72-6",{"v":100,"d":"100.00"},156.81,{"v":4,"d":"4.00"},6.27,"http://selleckchem.com/products/Vecuronium-Bromide.html","C34H57N2O4.Br","Bromide","ORG NC45","[Br-].CC(=O)OC1CC2CCC3C(CCC4(C)C3CC(C4OC(C)=O)[N+]5(C)CCCCC5)C2(C)CC1N6CCCCC6",{"v":1.73,"d":"1.730"},4,0,6]
["S1407","Bimatoprost","a4","L3900-04","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Bimatoprost(AGN 192024) is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.",415.57,"155206-00-1",{"v":36,"d":"36.00"},86.63,"<1","N/A","http://selleckchem.com/products/Bimatoprost.html","C25H37NO4","free base","AGN 192024","CCNC(=O)CCC\\C=C/CC1C(O)CC(O)C1/C=C/C(O)CCC2=CC=CC=C2",{"v":3.03,"d":"3.030"},1,4,12]
["S1408","Linezolid (PNU-100766)","b4","L3900-04","in 10mM DMSO","Antibiotics","Microbiology","Linezolid (Zyvoxid, Zyvoxam,PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.",337.35,"165800-03-3",{"v":67,"d":"67.00"},198.61,"<1","N/A","http://selleckchem.com/products/Linezolid(Zyvox).html","C16H20FN3O4","free base","Zyvoxid, Zyvoxam,PNU-100766","CC(=O)NCC1CN(C(=O)O1)C2=CC=C(N3CCOCC3)C(=C2)F",0.894,4,1,4]
["S1409","Alfuzosin HCl","c4","L3900-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Alfuzosin HCI(SL 77499 HCl)  is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).",425.91,"81403-68-1",{"v":85,"d":"85.00"},199.57,{"v":85,"d":"85.00"},199.57,"http://selleckchem.com/products/Alfuzosin-hydrochloride.html","C19H27N5O4.HCl","Hydrochloride","SL 77499 HCl","Cl.COC1=C(OC)C=C2C(=NC(=NC2=C1)N(C)CCCNC(=O)C3CCCO3)N",{"v":1.8,"d":"1.800"},6,2,8]
["S1415","Clopidogrel (SR-25990C) Bisulfate","d4","L3900-04","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Clopidogrel Bisulfate (SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix) is an oral, thienopyridine class antiplatelet agent.",{"v":419.9,"d":"419.90"},"120202-66-6",{"v":83,"d":"83.00"},197.67,{"v":78,"d":"78.00"},185.76,"http://selleckchem.com/products/Clopidogrel-bisulfate.html","C16H16ClNO2S.H2SO4","Bisulfate","SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix","COC(=O)C(N1CCC2=C(C1)C=CS2)C3=C(Cl)C=CC=C3.O[S](O)(=O)=O",3.128,2,0,4]
["S1425","Ranolazine 2HCl","e4","L3900-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine 2HCl (RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.",500.46,"95635-56-6",{"v":100,"d":"100.00"},199.82,{"v":100,"d":"100.00"},199.82,"http://selleckchem.com/products/Ranolazine-dihydrochloride.html","C24H33N3O4.2HCl","Dihydrochloride","RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride","Cl.Cl.COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",3.755,3,2,9]
["S1426","Repaglinide","f4","L3900-04","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Repaglinide (AG-EE 623 ZW) is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.",452.59,"135062-02-1",{"v":91,"d":"91.00"},201.06,"<1","N/A","http://selleckchem.com/products/Repaglinide.html","C27H36N2O4","free base","AG-EE 623 ZW","CCOC1=C(C=CC(=C1)CC(=O)NC(CC(C)C)C2=CC=CC=C2N3CCCCC3)C(O)=O",5.307,3,1,10]
["S1430","Rolipram (ZK-62711)","g4","L3900-04","in 10mM DMSO","PDE","Metabolism","The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.",275.34,"61413-54-5",{"v":55,"d":"55.00"},199.75,"<1","N/A","http://selleckchem.com/products/Rolipram.html","C16H21NO3","free base","ZK-62711, SB 95952","COC1=C(OC2CCCC2)C=C(C=C1)C3CNC(=O)C3",2.349,3,1,4]
["S1431","Sildenafil Citrate","h4","L3900-04","in 10mM DMSO","PDE","Metabolism","Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.",{"v":666.7,"d":"666.70"},"171599-83-0",{"v":20,"d":"20.00"},{"v":30,"d":"30.00"},"<1","N/A","http://selleckchem.com/products/Sildenafil-citrate.html","C22H30N6O4S.C6H8O7","Citrate","N/A","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.OC(=O)CC(O)(CC(O)=O)C(O)=O",-2.107,9,1,12]
["S1432","Sumatriptan Succinate","a5","L3900-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Sumatriptan Succinate (GR 43175) is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.",413.49,"103628-48-4",{"v":83,"d":"83.00"},200.73,{"v":83,"d":"83.00"},200.73,"http://selleckchem.com/products/Sumatriptan-succinate.html","C14H21N3O2S.C4H6O4","Succinate","GR 43175","CN[S](=O)(=O)CC1=CC=C2[NH]C=C(CCN(C)C)C2=C1.OC(=O)CCC(O)=O",-1.958,4,2,9]
["S1435","Tamsulosin hydrochloride","b5","L3900-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tamsulosin (Flomax) hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.",444.97,"106463-17-6",{"v":89,"d":"89.00"},200.01,"<1","N/A","https://www.selleckchem.com/products/Tamsulosin-hydrochloride.html","C20H28N2O5S.HCl","HCl","Flomax hydrochloride","CCOC1=C(OCCNC(C)CC2=CC=C(OC)C(=C2)[S](N)(=O)=O)C=CC=C1",2.719,5,2,11]
["S1437","Tizanidine HCl","c5","L3900-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.",290.17,"64461-82-1",{"v":10,"d":"10.00"},34.46,{"v":15,"d":"15.00"},51.69,"http://selleckchem.com/products/Tizanidine-hydrochloride.html","C9H8ClN5S.HCl","Hydrochloride","DS 103-282","Cl.ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1",2.199,3,2,2]
["S1438","Topiramate","d5","L3900-04","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.",339.36,"97240-79-4",{"v":68,"d":"68.00"},200.38,"<1","N/A","http://selleckchem.com/products/Topiramate.html","C12H21NO8S","free base","MCN 4853, RWJ 17021","CC1(C)OC2COC3(CO[S](N)(=O)=O)OC(C)(C)OC3C2O1",-1.932,6,1,3]
["S1439","Tranilast (SB 252218)","e5","L3900-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tranilast (SB 252218, MK-341, Rizaben, MK 341, Tranpro) is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.",327.33,"53902-12-8",{"v":66,"d":"66.00"},201.63,"<1","N/A","http://selleckchem.com/products/Tranilast.html","C18H17NO5","free base","SB 252218, MK-341, Rizaben, MK 341, Tranpro","COC1=C(OC)C=C(\\C=C\\C(=O)NC2=CC=CC=C2C(O)=O)C=C1",2.679,4,1,6]
["S1441","Venlafaxine HCl","f5","L3900-04","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Venlafaxine HCl(Wy 453 HCl) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.",313.86,"99300-78-4",{"v":55.5,"d":"55.50"},176.83,{"v":55.5,"d":"55.50"},176.83,"http://selleckchem.com/products/Venlafaxine-hydrochloride.html","C17H27NO2.HCl","Hydrochloride","Wy 453 HCl","Cl.COC1=CC=C(C=C1)C(CN(C)C)C2(O)CCCCC2",3.404,1,0,5]
["S1442","Voriconazole (UK-109496)","g5","L3900-04","in 10mM DMSO","Fungal,P450 (e.g. CYP17)","Metabolism","Voriconazole (Vfend,UK-109496) is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.",349.31,"137234-62-9",{"v":70,"d":"70.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/Voriconazole.html","C16H14F3N5O","free base","Vfend,UK-109496","CC(C1=NC=NC=C1F)C(O)(C[N]2C=NC=N2)C3=CC=C(F)C=C3F",2.071,4,0,5]
["S1443","Zileuton (A-64077)","h5","L3900-04","in 10mM DMSO","Apoptosis related,Ferroptosis,Lipoxygenase","Metabolism","Zileuton (A-64077, Abbott 64077, ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. Zileuton induces apoptosis while inhibits ferroptosis.",236.29,"111406-87-2",{"v":47,"d":"47.00"},198.91,"<1","N/A","http://selleckchem.com/products/Zileuton.html","C11H12N2O2S","free base","A-64077, Abbott 64077, ZYFLO","CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1",2.184,1,1,2]
["S1444","Ziprasidone HCl","a6","L3900-04","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.",{"v":449.4,"d":"449.40"},"122883-93-6",{"v":90,"d":"90.00"},200.27,"<1","N/A","http://selleckchem.com/products/Ziprasidone-hydrochloride.html","C21H21ClN4OS.HCl","Hydrochloride","CP-88059","Cl.ClC1=CC2=C(CC(=O)N2)C=C1CCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.641,2,1,4]
["S1445","Zonisamide","b6","L3900-04","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.",212.23,"68291-97-4",{"v":42,"d":"42.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/Zonisamide.html","C8H8N2O3S","free base","Zonegran,CI-912,AD 810","N[S](=O)(=O)CC1=NOC2=CC=CC=C12",0.411,4,1,2]
["S1452","Ispinesib (SB-715992)","c6","L3900-04","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death.",517.06,"336113-53-2",{"v":103,"d":"103.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Ispinesib-mesilate(SB-715992).html","C30H33ClN4O2","free base","CK0238273","CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4",5.259,3,1,9]
["S1453","Tipifarnib (R115777)","d6","L3900-04","in 10mM DMSO","FTase,Transferase","Metabolism","Tipifarnib (R115777, IND 58359) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.",{"v":489.4,"d":"489.40"},"192185-72-1",{"v":14,"d":"14.00"},28.61,"<1","N/A","http://selleckchem.com/products/Tipifarnib(R115777).html","C27H22Cl2N4O","free base","IND 58359","C[N]1C=NC=C1C(N)(C2=CC=C(Cl)C=C2)C3=CC4=C(C=C3)N(C)C(=O)C=C4C5=CC(=CC=C5)Cl",4.808,2,1,4]
["S1454","PHA-680632","e6","L3900-04","in 10mM DMSO","Aurora Kinase","Cell Cycle","PHA-680632 is a potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.",501.62,"398493-79-3",{"v":100,"d":"100.00"},199.35,"<1","N/A","http://selleckchem.com/products/PHA-680632.html","C28H35N7O2","free base","N/A","CCC1=CC=CC(=C1NC(=O)N2CC3=C(C2)C(=N[NH]3)NC(=O)C4=CC=C(C=C4)N5CCN(C)CC5)CC",4.339,3,3,6]
["S1455","Cilomilast","f6","L3900-04","in 10mM DMSO","PDE","Metabolism","Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.",343.42,"153259-65-5",{"v":69,"d":"69.00"},200.92,"<1","N/A","http://selleckchem.com/products/Cilomilast(SB-207499).html","C20H25NO4","free base","SB-207499","COC1=C(OC2CCCC2)C=C(C=C1)C3(CCC(CC3)C(O)=O)C#N",4.174,3,0,5]
["S1456","Zibotentan (ZD4054)","g6","L3900-04","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.",424.43,"186497-07-4",{"v":24,"d":"24.00"},56.55,"<1","N/A","http://selleckchem.com/products/Zibotentan(ZD4054).html","C19H16N6O4S","free base","N/A","COC1=NC(=CN=C1N[S](=O)(=O)C2=CC=CN=C2C3=CC=C(C=C3)C4=NN=CO4)C",1.456,9,1,6]
["S1457","Atazanavir (BMS-232632) Sulfate","h6","L3900-04","in 10mM DMSO","HIV Protease","Proteases","Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.",802.93,"229975-97-7",{"v":104,"d":"104.00"},129.53,"<1","N/A","http://selleckchem.com/products/Atazanavir.html","C38H52N6O7.H2SO4","Sulfate","BMS-232632-05, Reyataz","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C.O[S](O)(=O)=O",4.083,7,5,18]
["S1458","Neflamapimod (VX-745)","a7","L3900-04","in 10mM DMSO","p38 MAPK","MAPK","Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.",436.26,"209410-46-8",{"v":15,"d":"15.00"},34.38,"<1","N/A","http://selleckchem.com/products/VX-745.html","C19H9Cl2F2N3OS","free base","N/A","FC1=CC(=C(SC2=NN3C=NC(=O)C(=C3C=C2)C4=C(Cl)C=CC=C4Cl)C=C1)F",5.342,3,0,3]
["S1460","SP600125","b7","L3900-04","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,FLT3,JNK,Serine/threonin kinase,Trk receptor","MAPK","SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.",220.23,"129-56-6",{"v":44,"d":"44.00"},199.79,"<1","N/A","http://selleckchem.com/products/SP600125.html","C14H8N2O","free base","Nsc75890","O=C1C2=C(C=CC=C2)C3=N[NH]C4=CC=CC1=C34",2.994,2,1,0]
["S1462","AZD6482","c7","L3900-04","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.",408.45,"1173900-33-8",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://selleckchem.com/products/azd6482.html","C22H24N4O4","free base","KIN-193","CC(NC1=CC=CC=C1C(O)=O)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.003,4,1,5]
["S1465","Moxifloxacin (BAY12-8039) HCl","d7","L3900-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Moxifloxacin (Avelox, Avalox,BAY12-8039 HCl) is a fourth-generation synthetic fluoroquinolone antibacterial agent.",437.89,"186826-86-8",{"v":87,"d":"87.00"},198.68,{"v":60,"d":"60.00"},137.02,"https://www.selleckchem.com/products/Moxifloxacin-hcl.html","C21H24FN3O4.HCl","Hydrochloride","Avelox, Avalox,BAY12-8039 HCl","Cl.COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CC4CCCNC4C3)F)C5CC5",{"v":-0.32,"d":"-0.320"},3,1,4]
["S1467","Doxercalciferol","e7","L3900-04","in 10mM DMSO","Vitamin","Metabolism","Doxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.",412.65,"54573-75-0",{"v":83,"d":"83.00"},201.14,"<1","N/A","http://selleckchem.com/products/Doxercalciferol(Hectorol).html","C28H44O2","free base","1α-hydroxyvitamin D2","CC(C)C(C)/C=C/C(C)C1CCC2C(/CCCC12C)=C/C=C/3CC(O)CC(O)C3=C",6.337,0,2,5]
["S1468","Alfacalcidol","f7","L3900-04","in 10mM DMSO","Vitamin","Metabolism","Alfacalcidol (1-hydroxycholecalciferol) is a non-selective VDR activator medication.",400.64,"41294-56-8",{"v":80,"d":"80.00"},199.68,"<1","N/A","http://selleckchem.com/products/Alfacalcidol.html","C27H44O2","free base","1-hydroxycholecalciferol","CC(C)CCCC(C)C1CCC2/C(CCCC12C)=C\\C=C3/CC(O)CC(O)C3=C",{"v":6.53,"d":"6.530"},0,2,6]
["S1470","Orantinib (SU6668)","g7","L3900-04","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.",310.35,"252916-29-3",{"v":62,"d":"62.00"},199.77,"<1","N/A","http://selleckchem.com/products/TSU-68(SU6668).html","C18H18N2O3","free base","TSU-68","CC1=C(CCC(O)=O)C(=C([NH]1)/C=C/2C(=O)NC3=CC=CC=C23)C",2.868,2,2,4]
["S1472","Safinamide Mesylate","h7","L3900-04","in 10mM DMSO","MAO","Metabolism","Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.",398.45,"202825-46-5",{"v":80,"d":"80.00"},200.78,{"v":80,"d":"80.00"},200.78,"http://selleckchem.com/products/Safinamide-mesilate.html","C17H19FN2O2.CH4O3S","Mesylate","PNU-151774E,FCE28073","CC(NCC1=CC=C(OCC2=CC(=CC=C2)F)C=C1)C(N)=O.C[S](O)(=O)=O",2.064,2,2,7]
["S1475","Pimasertib (AS-703026)","a8","L3900-04","in 10mM DMSO","MEK","MAPK","Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.",{"v":431.2,"d":"431.20"},"1236699-92-5",{"v":86,"d":"86.00"},199.44,"<1","N/A","http://selleckchem.com/products/AS703026.html","C15H15FIN3O3","free base","MSC1936369B, SAR 245509","OCC(O)CNC(=O)C1=CC=NC=C1NC2=C(F)C=C(I)C=C2",1.171,2,4,6]
["S1480","Lomibuvir (VX-222)","b8","L3900-04","in 10mM DMSO","HCV Protease","Proteases","Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.",445.61,"1026785-59-0",{"v":89,"d":"89.00"},199.73,"<1","N/A","http://selleckchem.com/products/VX-222.html","C25H35NO4S","free base","VCH-222","CC1CCC(CC1)C(=O)N(C2CCC(O)CC2)C3=C(SC(=C3)C#CC(C)(C)C)C(O)=O",6.021,2,1,6]
["S1481","Zosuquidar (LY335979) 3HCl","c8","L3900-04","in 10mM DMSO","P-gp","Transmembrane Transporters","Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.",636.99,"167465-36-3",{"v":100,"d":"100.00"},156.99,{"v":23,"d":"23.00"},36.11,"http://selleckchem.com/products/LY335979.html","C32H31F2N3O2.3HCl","Trihydrochlorid","RS 33295-198 (D06387) 3HCl","Cl.Cl.Cl.OC(COC1=CC=CC2=C1C=CC=N2)CN3CCN(CC3)C4C5=C(C=CC=C5)C6C(C7=C4C=CC=C7)C6(F)F",5.845,2,1,6]
["S1482","Daclatasvir (BMS-790052)","d8","L3900-04","in 10mM DMSO","HCV Protease","Proteases","Daclatasvir (BMS-790052, EBP883) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.",738.88,"1009119-64-5",{"v":148,"d":"148.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/BMS-790052.html","C40H50N8O6","free base","EBP883","COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C([NH]5)C6CCCN6C(=O)C(NC(=O)OC)C(C)C",5.048,8,4,13]
["S1483","Iloperidone","e8","L3900-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Iloperidone (HP873) is a dopamine (D2)/serotonin (5-HT2) receptor antagonist, used for the treatment of schizophrenia.",426.48,"133454-47-4",{"v":27,"d":"27.00"},63.31,"<1","N/A","http://selleckchem.com/products/Iloperidone(Fanapt).html","C24H27FN2O4","free base","HP873","COC1=C(OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C=CC(=C1)C(C)=O",4.016,5,0,8]
["S1485","HMN-214","f8","L3900-04","in 10mM DMSO","PLK","Cell Cycle","HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.",424.47,"173529-46-9",{"v":12,"d":"12.00"},28.27,"<1","N/A","http://selleckchem.com/products/HMN-214.html","C22H20N2O5S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)N(C(C)=O)C2=C(C=CC=C2)\\C=C\\C3=CC=[N+]([O-])C=C3",2.282,4,0,6]
["S1486","AEE788 (NVP-AEE788)","g8","L3900-04","in 10mM DMSO","EGFR,HER2,VEGFR","Protein Tyrosine Kinase","AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.",440.58,"497839-62-0",{"v":88,"d":"88.00"},199.74,"<1","N/A","http://selleckchem.com/products/AEE788.html","C27H32N6","free base","N/A","CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC(C)C5=CC=CC=C5)N=CN=C4[NH]3",5.042,2,2,7]
["S1487","PHA-793887","h8","L3900-04","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1.",361.48,"718630-59-2",{"v":72,"d":"72.00"},199.18,"<1","N/A","http://selleckchem.com/products/PHA-793887.html","C19H31N5O2","free base","N/A","CC(C)CC(=O)NC1=N[NH]C2=C1CN(C(=O)C3CCN(C)CC3)C2(C)C",1.895,3,2,4]
["S1488","Naratriptan HCl","a9","L3900-04","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Naratriptan HCl is a triptan agent that is used for the treatment of migraine headaches.",371.93,"143388-64-1",{"v":74,"d":"74.00"},198.96,{"v":22,"d":"22.00"},59.15,"http://selleckchem.com/products/Naratriptan(Amerge).html","C17H25N3O2S.HCl","Hydrochloride","N/A","Cl.CN[S](=O)(=O)CCC1=CC=C2[NH]C=C(C3CCN(C)CC3)C2=C1",2.435,2,2,5]
["S1490","Ponatinib (AP24534)","b9","L3900-04","in 10mM DMSO","Autophagy,Bcr-Abl,FGFR,PDGFR,Src,VEGFR","Angiogenesis","Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.",532.56,"943319-70-8",{"v":30,"d":"30.00"},56.33,"<1","N/A","http://selleckchem.com/products/AP24534.html","C29H27F3N6O","free base","AP24534","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F",4.884,3,1,7]
["S1491","Fludarabine (NSC 118218)","c9","L3900-04","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite,STAT","JAK/STAT","Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.",285.23,"21679-14-1",{"v":57,"d":"57.00"},199.84,"<1","N/A","http://selleckchem.com/products/Fludarabine(Fludara).html","C10H12FN5O4","Free Base","FaraA, Fludarabinum, NSC 118218","NC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)F",-1.312,4,4,2]
["S1497","Pralatrexate (NSC 754230)","d9","L3900-04","in 10mM DMSO","Apoptosis related,DHFR","Metabolism","Pralatrexate (NSC 754230) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.",477.47,"146464-95-1",{"v":28,"d":"28.00"},58.64,"<1","N/A","http://selleckchem.com/products/Pralatrexate(Folotyn).html","C23H23N7O5","free base","NSC 754230","NC1=NC(=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1)N",{"v":1.94,"d":"1.940"},7,3,10]
["S1499","Cefaclor","e9","L3900-04","in 10mM DMSO","Antibiotics","Microbiology","Cefaclor (Cefachlor, Cefaclorum) is a cephalosporin antibiotic.",385.82,"70356-03-5",{"v":11,"d":"11.00"},28.51,"<1","N/A","http://selleckchem.com/products/Cefaclor-(Ceclor).html","C15H14ClN3O4S.H2O","monohydrate","Cefachlor, Cefaclorum","O.NC(C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)Cl)C3=CC=CC=C3",{"v":-2.54,"d":"-2.540"},3,2,4]
["S1500","Betamethasone","f9","L3900-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.",392.46,"378-44-9",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Betamethasone-(Celestone).html","C22H29FO5","Free Base","NSC-39470, SCH-4831","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1501","Mycophenolate mofetil (RS-61443)","g9","L3900-04","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Mycophenolate Mofetil (RS 61443, Mycophenolic acid morpholinoethyl ester, CellCept, TM-MMF) is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Mycophenolate Mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.",433.49,"128794-94-5",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/Mycophenolate-mofetil-(CellCept).html","C23H31NO7","free base","Mycophenolic acid morpholinoethyl ester, CellCept, RS 61443, TM-MMF","COC1=C(C)C2=C(C(=O)OC2)C(=C1C\\C=C(C)\\CCC(=O)OCCN3CCOCC3)O",3.209,6,1,10]
["S1505","Aztreonam","h9","L3900-04","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.",435.43,"78110-38-0",{"v":87,"d":"87.00"},{"v":199.8,"d":"199.80"},{"v":11,"d":"11.00"},25.26,"http://selleckchem.com/products/Aztreonam(Azactam).html","C13H17N5O8S2","free base","SQ 26776","CC1C(NC(=O)\\C(=N/OC(C)(C)C(O)=O)C2=CSC(=N2)N)C(=O)N1[S](O)(=O)=O",-1.035,6,2,7]
["S1508","Alprostadil","a10","L3900-04","in 10mM DMSO","PGES","Endocrinology & Hormones","Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.",354.48,"745-65-3",{"v":71,"d":"71.00"},200.29,"<1","N/A","http://selleckchem.com/products/Alprostadil(Caverject).html","C20H34O5","free base","Prostaglandin-E1, PGE1, Edex, Muse, Liprostin","CCCCCC(O)/C=C/C1C(O)CC(=O)C1CCCCCCC(O)=O",3.644,2,2,13]
["S1511","Lactulose","b10","L3900-04","in 10mM DMSO","Others","Others","Lactulose, a disaccharide composed of galactose and fructose, is a stimulator of health-promoting bacterium growth in the gastrointestinal tract, used to treat chronic constipation and hepatic encephalopathy.",{"v":342.3,"d":"342.30"},"4618-18-2",{"v":68,"d":"68.00"},198.66,{"v":68,"d":"68.00"},198.66,"http://selleckchem.com/products/Lactulose(Enulose).html","C12H22O11","free base","N/A","OCC(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)C(=O)CO",-4.621,3,8,8]
["S1512","Tadalafil (IC351)","c10","L3900-04","in 10mM DMSO","PDE","Metabolism","Tadalafil (IC351) is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibits PDE11",{"v":389.4,"d":"389.40"},"171596-29-5",{"v":78,"d":"78.00"},200.31,"<1","N/A","http://selleckchem.com/products/Tadalafil(Cialis).html","C22H19N3O4","free base","IC351","CN1CC(=O)N2C(CC3=C([NH]C4=C3C=CC=C4)C2C5=CC=C6OCOC6=C5)C1=O",2.183,4,1,1]
["S1514","Cyclosporine","d10","L3900-04","in 10mM DMSO","Immunology & Inflammation related,phosphatase","Metabolism","Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.",1202.61,"79217-60-0",{"v":100,"d":"100.00"},83.15,"<1","N/A","http://selleckchem.com/products/Cyclosporine.html","C62H111N11O12","free base","Neoral","CCC1NC(=O)C(C(O)C(C)C\\C=C\\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C",4.333,11,5,15]
["S1515","Pracinostat (SB939)","e10","L3900-04","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.",358.48,"929016-96-6",{"v":72,"d":"72.00"},200.85,"<1","N/A","http://selleckchem.com/products/SB939.html","C20H30N4O2","free base","N/A","CCCCC1=NC2=CC(=CC=C2[N]1CCN(CC)CC)\\C=C\\C(=O)NO",{"v":3.71,"d":"3.710"},2,1,10]
["S1517","Natamycin","f10","L3900-04","in 10mM DMSO","Fungal","Microbiology","Natamycin (Pimaricin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil; with little to no flavour interference",665.73,"7681-93-8",{"v":7,"d":"7.00"},10.51,"<1","N/A","http://selleckchem.com/products/Natamycin(Pimaricin).html","C33H47NO13","free base","Pimaricin","CC1C/C=C/C=C/C=C/C=C/C(CC2OC(O)(CC(O)CC3OC3/C=C/C(=O)O1)CC(O)C2C(O)=O)OC4OC(C)C(O)C(N)C4O",-2.824,7,5,3]
["S1524","AT7519","g10","L3900-04","in 10mM DMSO","Apoptosis related,CDK,GSK-3","Cell Cycle","AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also decrease GSK3β phosphorylation. AT7519 induces apoptosis. Phase 2.",382.24,"844442-38-2",{"v":10,"d":"10.00"},26.16,"<1","N/A","http://selleckchem.com/products/AT7519.html","C16H17Cl2N5O2","Free Base","N/A","ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",1.599,3,4,4]
["S1525","Adavosertib (MK-1775)","h10","L3900-04","in 10mM DMSO","Wee1","Cell Cycle","Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.",{"v":500.6,"d":"500.60"},"955365-80-7",{"v":80,"d":"80.00"},159.81,"N/A","N/A","http://selleckchem.com/products/MK-1775.html","C27H32N8O2","free base","AZD1775","CN1CCN(CC1)C2=CC=C(NC3=NC4=C(C=N3)C(=O)N(CC=C)N4C5=NC(=CC=C5)C(C)(C)O)C=C2",4.158,4,1,7]
["S1526","Quizartinib (AC220)","a11","L3900-04","in 10mM DMSO","Apoptosis related,FLT3,Target Protein Ligand","Angiogenesis","Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.",560.67,"950769-58-1",{"v":33,"d":"33.00"},58.86,"<1","N/A","http://selleckchem.com/products/AC-220.html","C29H32N6O4S","free base","N/A","CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=C[N]4C(=N3)SC5=CC(=CC=C45)OCCN6CCOCC6",5.064,6,2,8]
["S1528","LY2811376","b11","L3900-04","in 10mM DMSO","BACE,Beta Amyloid","Proteases","LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.",320.36,"1194044-20-6",{"v":16,"d":"16.00"},49.94,"<1","N/A","http://selleckchem.com/products/LY2811376.html","C15H14F2N4S","free base","N/A","CC1(CCSC(=N1)N)C2=CC(=C(F)C=C2F)C3=CN=CN=C3",2.478,3,1,2]
["S1532","AZD7762","c11","L3900-04","in 10mM DMSO","Chk","Cell Cycle","AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.",362.42,"860352-01-8",{"v":50,"d":"50.00"},137.96,"<1","N/A","http://selleckchem.com/products/AZD7762.html","C17H19FN4O2S","free base","N/A","NC(=O)NC1=C(SC(=C1)C2=CC(=CC=C2)F)C(=O)NC3CCCNC3",2.009,2,4,4]
["S1533","R406 (free base)","d11","L3900-04","in 10mM DMSO","Apoptosis related,FLT3,Syk","Angiogenesis","R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 (free base) triggers apoptosis. Phase 1.",470.45,"841290-80-0",{"v":21,"d":"21.00"},44.64,"<1","N/A","http://selleckchem.com/products/R406(free-base).html","C22H23FN6O5","free base","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC(=C(F)C=N2)NC3=NC4=C(OC(C)(C)C(=O)N4)C=C3)OC",3.881,8,3,7]
["S1536","CP-673451","e11","L3900-04","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.",{"v":417.5,"d":"417.50"},"343787-29-1",{"v":28,"d":"28.00"},67.07,"<1","N/A","http://selleckchem.com/products/CP-673451.html","C24H27N5O2","free base","N/A","COCCOC1=CC=C2[N](C=NC2=C1)C3=NC4=C(C=CC=C4C=C3)N5CCC(N)CC5",3.011,4,1,6]
["S1537","Vadimezan (ASA404)","f11","L3900-04","in 10mM DMSO","Antiviral,IFN,STING,TNF-alpha,VDA","Angiogenesis","Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.",282.29,"117570-53-3",{"v":7,"d":"7.00"},{"v":24.8,"d":"24.80"},"<1","N/A","http://selleckchem.com/products/DMXAA(ASA404).html","C17H14O4","free base","NSC 640488, DMXAA","CC1=C(C)C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(O)=O",3.601,3,0,2]
["S1538","Telaprevir (VX-950)","g11","L3900-04","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Telaprevir (VX-950, LY-570310, MP-424) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.",679.85,"402957-28-2",{"v":136,"d":"136.00"},200.04,"<1","N/A","http://selleckchem.com/products/Telaprevir(VX-950).html","C36H53N7O6","free base","LY-570310, MP-424,VX-950","CCCC(NC(=O)C1C2CCCC2CN1C(=O)C(NC(=O)C(NC(=O)C3=NC=CN=C3)C4CCCCC4)C(C)(C)C)C(=O)C(=O)NC5CC5",2.685,8,4,14]
["S1540","Saxagliptin (BMS-477118)","h11","L3900-04","in 10mM DMSO","DPP","Proteases","Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",315.41,"361442-04-8",{"v":63,"d":"63.00"},199.74,{"v":63,"d":"63.00"},199.74,"http://selleckchem.com/products/Saxagliptin(Onglyza).html","C18H25N3O2","Free Base","Onglyza,BMS-477118","NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.275,1,1,2]
["S1541","Selisistat (EX 527)","a2","L3900-05","in 10mM DMSO","Sirtuin","Epigenetics","Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.",248.71,"49843-98-3",{"v":49,"d":"49.00"},197.02,"<1","N/A","http://selleckchem.com/products/EX-527.html","C13H13ClN2O","free base","SEN0014196","NC(=O)C1CCCC2=C1[NH]C3=C2C=C(Cl)C=C3",3.149,1,2,1]
["S1547","Febuxostat","b2","L3900-05","in 10mM DMSO","ROS","Immunology & Inflammation","Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.",316.37,"144060-53-7",{"v":63,"d":"63.00"},199.13,"<1","N/A","http://selleckchem.com/products/Febuxostat(Uloric).html","C16H16N2O3S","free base","TMX 67, TEI-6720","CC(C)COC1=C(C=C(C=C1)C2=NC(=C(S2)C(O)=O)C)C#N",3.468,3,0,5]
["S1548","Dapagliflozin (BMS-512148)","c2","L3900-05","in 10mM DMSO","SGLT","GPCR & G Protein","Dapagliflozin (BMS-512148) is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.",408.87,"461432-26-8",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Dapagliflozin.html","C21H25ClO6","free base","BMS-512148","CCOC1=CC=C(CC2=CC(=CC=C2Cl)C3OC(CO)C(O)C(O)C3O)C=C1",2.409,2,4,6]
["S1549","Nebivolol hydrochloride (R-65824)","d2","L3900-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Nebivolol HCl (R-65824) selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.",{"v":441.9,"d":"441.90"},"152520-56-4",{"v":88,"d":"88.00"},199.14,"<1","N/A","http://selleckchem.com/products/Nebivolol(Bystolic).html","C22H25F2NO4.HCl","Hydrochloride","R-65824 hydrochloride","Cl.OC(CNCC(O)C1CCC2=C(O1)C=CC(=C2)F)C3CCC4=CC(=CC=C4O3)F",3.939,2,3,6]
["S1550","Pimobendan","e2","L3900-05","in 10mM DMSO","PDE","Metabolism","Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.",334.37,"74150-27-9",{"v":67,"d":"67.00"},200.38,"<1","N/A","http://selleckchem.com/products/Pimobendan(Vetmedin).html","C19H18N4O2","free base","UD-CG 115 BS","COC1=CC=C(C=C1)C2=NC3=CC(=CC=C3[NH]2)C4=NNC(=O)CC4C",2.936,4,2,3]
["S1553","Delafloxacin (ABT-492)","f2","L3900-05","in 10mM DMSO","Anti-infection","Immunology & Inflammation","Delafloxacin (ABT-492, RX-3341, WQ-3034) is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.",440.76,"189279-58-1, 339591-82-1 (sodium salt)",{"v":88,"d":"88.00"},199.66,"<1","N/A","http://www.selleck.cn/products/ABT-492.html","C18H12ClF3N4O4","free base","RX-3341J, WQ-3034","NC1=C(F)C=C(F)C(=N1)N2C=C(C(O)=O)C(=O)C3=CC(=C(N4CC(O)C4)C(=C23)Cl)F",2.682,3,2,3]
["S1555","AZD8055","g2","L3900-05","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.",465.54,"1009298-09-2",{"v":50,"d":"50.00"},{"v":107.4,"d":"107.40"},"<1","N/A","http://selleckchem.com/products/AZD8055.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=C(C=C2)C(=NC(=N3)N4CCOCC4C)N5CCOCC5C",3.274,6,1,5]
["S1556","PHT-427","h2","L3900-05","in 10mM DMSO","Akt,PDPK1","PI3K/Akt/mTOR","PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.",409.61,"1191951-57-1",{"v":82,"d":"82.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHT-427.html","C20H31N3O2S2","free base","CS-0223","CCCCCCCCCCCCC1=CC=C(C=C1)[S](=O)(=O)NC2=NN=CS2",6.296,4,1,14]
["S1557","KRN 633","a3","L3900-05","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell.",416.86,"286370-15-8",{"v":9,"d":"9.00"},21.59,"<1","N/A","http://selleckchem.com/products/KRN-633.html","C20H21ClN4O4","free base","N/A","CCCNC(=O)NC1=CC=C(OC2=NC=NC3=CC(=C(OC)C=C23)OC)C=C1Cl",4.107,6,2,7]
["S1558","AT7867","b3","L3900-05","in 10mM DMSO","Akt,S6 Kinase","PI3K/Akt/mTOR","AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.",337.85,"857531-00-1",{"v":68,"d":"68.00"},201.27,"<1","N/A","http://selleckchem.com/products/AT7867.html","C20H20ClN3","free base","N/A","ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=C[NH]N=C4",{"v":3.85,"d":"3.850"},1,2,3]
["S1561","BMS-777607","c3","L3900-05","in 10mM DMSO","Axl,c-Met,RON,Tyro3","Protein Tyrosine Kinase","BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.",512.89,"1025720-94-8",{"v":47,"d":"47.00"},91.64,"<1","N/A","http://selleckchem.com/products/BMS-777607.html","C25H19ClF2N4O4","free base","BMS 817378","CCOC1=C(C(=O)NC2=CC=C(OC3=CC=NC(=C3Cl)N)C(=C2)F)C(=O)N(C=C1)C4=CC=C(F)C=C4",3.517,5,2,7]
["S1565","Lumacaftor (VX-809)","d3","L3900-05","in 10mM DMSO","CFTR","Transmembrane Transporters","Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.",452.41,"936727-05-8",{"v":90,"d":"90.00"},198.93,"<1","N/A","http://selleckchem.com/products/VX-809.html","C24H18F2N2O5","free base","VRT 826809","CC1=C(N=C(NC(=O)C2(CC2)C3=CC4=C(OC(F)(F)O4)C=C3)C=C1)C5=CC=CC(=C5)C(O)=O",6.411,5,1,5]
["S1567","Pomalidomide (CC-4047)","e3","L3900-05","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.",273.24,"19171-19-8",{"v":54,"d":"54.00"},197.63,"<1","N/A","http://selleckchem.com/products/Pomalidomide(CC-4047).html","C13H11N3O4","free base","CC-4047","NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",{"v":-0.65,"d":"-0.650"},4,2,1]
["S1569","Tazarotene","f3","L3900-05","in 10mM DMSO","Retinoid Receptor","Metabolism","Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.",351.46,"118292-40-3",{"v":10,"d":"10.00"},28.45,"<1","N/A","http://selleckchem.com/products/Tazarotene(Avage).html","C21H21NO2S","free base","AGN190168","CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(SCCC3(C)C)C=C2",4.951,3,0,5]
["S1573","Fasudil (HA-1077) HCl","g3","L3900-05","in 10mM DMSO","Autophagy,Calcium Channel,MLCK,PKA,PKC,PKG,Rho,ROCK","Cell Cycle","Fasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.",327.83,"105628-07-7",{"v":5,"d":"5.00"},15.25,{"v":65,"d":"65.00"},198.27,"http://selleckchem.com/products/Fasudil-HCl(HA-1077).html","C14H17N3O2S.HCl","Hydrochloride","AT-877,HA-1077 HCl","Cl.O=[S](=O)(N1CCCNCC1)C2=C3C=CN=CC3=CC=C2",{"v":0.57,"d":"0.570"},3,1,2]
["S1574","Doramapimod (BIRB 796)","h3","L3900-05","in 10mM DMSO","JNK,p38 MAPK,Raf,Src","MAPK","Doramapimod (BIRB 796) is a  pan-p38 MAPK inhibitor with IC50 of  38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2.",527.66,"285983-48-4",{"v":100,"d":"100.00"},189.52,"<1","N/A","http://selleckchem.com/products/BIRB-796-(Doramapimod).html","C31H37N5O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5)C(C)(C)C",5.907,4,2,8]
["S1576","Sulfasalazine (NSC 667219)","a4","L3900-05","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1","N/A","http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1578","Candesartan (CV-11974)","b4","L3900-05","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.",440.45,"139481-59-7",{"v":88,"d":"88.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/Candesartan(Atacand).html","C24H20N6O3","free base","CV-11974","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5)C(=CC=C2)C(O)=O",4.626,6,1,7]
["S1591","Bestatin (NK421)","c4","L3900-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bestatin (Ubenimex,NK421) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.",308.37,"58970-76-6",{"v":4,"d":"4.00"},12.97,"<1","N/A","http://www.selleck.cn/products/Ubenimex(Bestatin).html","C16H24N2O4","Free Base","Ubenimex,NK421","CC(C)CC(NC(=O)C(O)C(N)CC1=CC=CC=C1)C(O)=O",{"v":-1.34,"d":"-1.340"},2,3,8]
["S1593","Apixaban (BMS 562247-01)","d4","L3900-05","in 10mM DMSO","Factor Xa","Metabolism","Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.",{"v":459.5,"d":"459.50"},"503612-47-3",{"v":18,"d":"18.00"},39.17,"<1","N/A","http://selleckchem.com/products/Apixaban(BMS-562247-01).html","C25H25N5O4","free base","BMS 562247-01","COC1=CC=C(C=C1)[N]2N=C(C(N)=O)C3=C2C(=O)N(CC3)C4=CC=C(C=C4)N5CCCCC5=O",2.865,5,1,5]
["S1594","Semagacestat (LY450139)","e4","L3900-05","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.",361.44,"425386-60-3",{"v":72,"d":"72.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Semagacestat(LY450139).html","C19H27N3O4","free base","N/A","CC(C)C(O)C(=O)NC(C)C(=O)NC1C(=O)N(C)CCC2=C1C=CC=C2",0.632,3,3,5]
["S1601","Reserpine","f4","L3900-05","in 10mM DMSO","VMAT","Transmembrane Transporters","Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).",608.68,"50-55-5",{"v":13,"d":"13.00"},21.36,"<1","N/A","http://selleckchem.com/products/Reserpine.html","C33H40N2O9","free base","N/A","COC1C(CC2CN3CCC4=C([NH]C5=C4C=CC(=C5)OC)C3CC2C1C(=O)OC)OC(=O)C6=CC(=C(OC)C(=C6)OC)OC",4.242,9,1,10]
["S1603","Furosemide (NSC 269420)","g4","L3900-05","in 10mM DMSO","NKCC","Transmembrane Transporters","Furosemide (NSC 269420) is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.",330.74,"54-31-9",{"v":66,"d":"66.00"},199.55,"<1","N/A","http://selleckchem.com/products/Furosemide(Lasix).html","C12H11ClN2O5S","free base","NSC 269420","N[S](=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O",1.403,4,2,5]
["S1604","Olmesartan Medoxomil","h4","L3900-05","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Olmesartan Medoxomil (CS-866,RNH-6270) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.",558.59,"144689-63-4",{"v":89,"d":"89.00"},159.33,"<1","N/A","http://selleckchem.com/products/olmesartan-medoxomil-Benicar.html","C29H30N6O6","free base","CS-866,RNH-6270","CCCC1=NC(=C([N]1CC2=CC=C(C=C2)C3=CC=CC=C3C4=N[NH]N=N4)C(=O)OCC5=C(C)OC(=O)O5)C(C)(C)O",4.814,9,1,11]
["S1605","Cefdinir","a5","L3900-05","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.",395.41,"91832-40-5",{"v":79,"d":"79.00"},199.79,"<1","N/A","http://selleckchem.com/products/Cefdinir(Omnicef).html","C14H13N5O5S2","free base","FK 482, PD 134393, CI-983","NC1=NC(=CS1)C(=N/O)/C(=O)NC2C3SCC(=C(N3C2=O)C(O)=O)C=C",-0.172,5,2,5]
["S1606","Clotrimazole","b5","L3900-05","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Fungal","Microbiology","Clotrimazole (BAY b 5097, FB 5097) alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.",344.84,"23593-75-1",{"v":11,"d":"11.00"},{"v":31.9,"d":"31.90"},"<1","N/A","http://selleckchem.com/products/Clotrimazole(Canesten).html","C22H17ClN2","free base","BAY b 5097, FB 5097","ClC1=C(C=CC=C1)C([N]2C=CN=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.222,1,0,4]
["S1607","Rizatriptan Benzoate","c5","L3900-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Rizatriptan Benzoate (MK-462) is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.",391.47,"145202-66-0",{"v":20,"d":"20.00"},51.09,{"v":46,"d":"46.00"},117.51,"http://selleckchem.com/products/Rizatriptan-Benzoate(Maxalt).html","C22H25N5O2","Benzoate","MK-462 Benzoate","CN(C)CCC1=C[NH]C2=C1C=C(C[N]3C=NC=N3)C=C2.OC(=O)C4=CC=CC=C4",0.492,3,1,6]
["S1608","Pyridostigmine Bromide","d5","L3900-05","in 10mM DMSO","AChR","Neuronal Signaling","Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.",261.12,"101-26-8",{"v":52,"d":"52.00"},199.14,{"v":52,"d":"52.00"},199.14,"http://selleckchem.com/products/Pyridostigmine-Bromide(Mestinon).html","C9H13BrN2O2","Bromide","N/A","[Br-].CN(C)C(=O)OC1=C[N+](=CC=C1)C",-1.014,2,0,2]
["S1609","Methimazole","e5","L3900-05","in 10mM DMSO","Others","Others","Methimazole (Tapazole, Thiamazole) is an antithyroid medicine.",114.17,"60-56-0",{"v":23,"d":"23.00"},201.45,{"v":23,"d":"23.00"},201.45,"http://selleckchem.com/products/Methimazole(Tapazole).html","C4H6N2S","free base","Tapazole, Thiamazole","CN1C=CNC1=S",0.414,0,1,0]
["S1610","Metolazone","f5","L3900-05","in 10mM DMSO","Others","Others","Metolazone (SR 720-22) is a diuretic that primarily used to treat congestive heart failure and high blood pressure.",365.83,"17560-51-9",{"v":73,"d":"73.00"},199.55,"<1","N/A","http://selleckchem.com/products/Metolazone(Zaroxolyn).html","C16H16ClN3O3S","free base","SR 720-22","CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)[S](N)(=O)=O)Cl",2.463,3,2,2]
["S1611","Cefoperazone","g5","L3900-05","in 10mM DMSO","Antibiotics","Microbiology","Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.",645.67,"62893-19-0",{"v":100,"d":"100.00"},154.88,"<1","N/A","http://selleckchem.com/products/cefoperazone-cefobid.html","C25H27N9O8S2","free base","N/A","CCN1CCN(C(=O)NC(C(=O)NC2C3SCC(=C(N3C2=O)C(O)=O)CSC4=NN=N[N]4C)C5=CC=C(O)C=C5)C(=O)C1=O",-0.792,9,3,9]
["S1613","Silodosin","h5","L3900-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Silodosin (KAD 3213, KMD 3213) is a highly selective α1A-adrenoceptor antagonist, used in treatment of benign prostatic hyperplasia.",495.53,"160970-54-7",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/Silodosin(Rapaflo).html","C25H32F3N3O4","free base","KAD 3213, KMD 3213","CC(CC1=CC2=C(N(CCCO)CC2)C(=C1)C(N)=O)NCCOC3=CC=CC=C3OCC(F)(F)F",3.451,3,3,14]
["S1614","Riluzole (PK 26124)","a6","L3900-05","in 10mM DMSO","GluR,Sodium Channel","Transmembrane Transporters","Riluzole (PK 26124, RP-54274) is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.",{"v":234.2,"d":"234.20"},"1744-22-5",{"v":46,"d":"46.00"},196.41,"<1","N/A","http://selleckchem.com/products/Riluzole(Rilutek).html","C8H5F3N2OS","free base","RP-54274, PK 26124","NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2",3.828,2,1,2]
["S1619","Prilocaine","b6","L3900-05","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Prilocaine (NSC 40027) is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.",220.31,"721-50-6",{"v":44,"d":"44.00"},199.72,"<1","N/A","http://selleckchem.com/products/Prilocaine.html","C13H20N2O","free base","NSC 40027","CCCNC(C)C(=O)NC1=C(C)C=CC=C1",2.263,1,2,5]
["S1620","Darunavir Ethanolate","c6","L3900-05","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.",593.73,"635728-49-3",{"v":100,"d":"100.00"},168.43,"<1","N/A","http://selleckchem.com/products/Darunavir-Ethanolate(Prezista).html","C27H37N3O7S.C2H5OH","Ethanolate","TMC-114, UIC 94017","CCO.CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2COC3OCCC23)[S](=O)(=O)C4=CC=C(N)C=C4",2.622,6,4,12]
["S1622","Prednisone (NSC-10023)","d6","L3900-05","in 10mM DMSO","Glucocorticoid Receptor,Immunology & Inflammation related","Endocrinology & Hormones","Prednisone (NSC-10023, Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.",358.43,"53-03-2",{"v":71,"d":"71.00"},198.09,"<1","N/A","http://selleckchem.com/products/Prednisone.html","C21H26O5","free base","Adasone,NSC-10023","CC12CC(=O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO",1.217,3,1,2]
["S1625","Ethinyl Estradiol","e6","L3900-05","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.",{"v":296.4,"d":"296.40"},"57-63-6",{"v":59,"d":"59.00"},199.06,"<1","N/A","http://selleckchem.com/products/Ethinyl-Estradiol.html","C20H24O2","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2(O)C#C",4.886,0,1,0]
["S1626","Naproxen Sodium","f6","L3900-05","in 10mM DMSO","COX","Neuronal Signaling","Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.",252.24,"26159-34-2",{"v":3,"d":"3.00"},11.89,{"v":50,"d":"50.00"},198.22,"http://selleckchem.com/products/Naproxen-Sodium(Aleve).html","C14H13NaO3","Sodium Salt","RS-3650","[Na+].COC1=CC=C2C=C(C=CC2=C1)C(C)C([O-])=O",1.375,1,0,3]
["S1627","Nitazoxanide (NSC 697855)","g6","L3900-05","in 10mM DMSO","Autophagy,Influenza Virus,mTOR,Serotonin Transporter","Microbiology","Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.",307.28,"55981-09-4",{"v":62,"d":"62.00"},201.77,"<1","N/A","http://selleckchem.com/products/Nitazoxanide(Alinia).html","C12H9N3O5S","free base","NTZ, NSC 697855","CC(=O)OC1=C(C=CC=C1)C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.398,4,1,5]
["S1628","Triamcinolone Acetonide","h6","L3900-05","in 10mM DMSO","Glucocorticoid Receptor","Metabolism","Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.",{"v":434.5,"d":"434.50"},"76-25-5",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/Triamcinolone-Acetonide.html","C24H31FO6","free base","N/A","CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CO",1.157,4,2,2]
["S1629","Orlistat (Ro 18-0647)","a7","L3900-05","in 10mM DMSO","Apoptosis related,Fatty Acid Synthase,Lipase","Metabolism","Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.",495.73,"96829-58-2",{"v":99,"d":"99.00"},199.71,"<1","N/A","http://selleckchem.com/products/Orlistat(Alli).html","C29H53NO5","free base","Tetrahydrolipstatin,Ro 18-0647","CCCCCCCCCCCC(CC1OC(=O)C1CCCCCC)OC(=O)C(CC(C)C)NC=O",8.333,5,1,23]
["S1630","Allopurinol","b7","L3900-05","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.",136.11,"315-30-0",{"v":27,"d":"27.00"},198.37,{"v":4,"d":"4.00"},29.39,"http://selleckchem.com/products/Allopurinol(Zyloprim).html","C5H4N4O","Free Base","N/A","O=C1N=CN=C2NNC=C12",-2.125,3,2,0]
["S1631","Allopurinol Sodium","c7","L3900-05","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol Sodium  is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.",{"v":159.1,"d":"159.10"},"17795-21-0",{"v":32,"d":"32.00"},201.13,{"v":32,"d":"32.00"},201.13,"http://selleckchem.com/products/Allopurinol-Sodium(Aloprim).html","C5H4N4NaO","Sodium Salt","N/A","[Na+].O=C1NC=NC2=C1C=N[NH]2",-0.681,3,2,0]
["S1633","Zafirlukast (ICI-204219)","d7","L3900-05","in 10mM DMSO","LTR","Immunology & Inflammation","Zafirlukast (ICI-204219) is an oral leukotriene receptor antagonist (LTRA), used to prevent asthma symptoms.",575.68,"107753-78-6",{"v":100,"d":"100.00"},173.71,"<1","N/A","http://selleckchem.com/products/Zafirlukast(Accolate).html","C31H33N3O6S","free base","ICI-204219","COC1=CC(=CC=C1CC2=C[N](C)C3=C2C=C(NC(=O)OC4CCCC4)C=C3)C(=O)N[S](=O)(=O)C5=CC=CC=C5C",6.299,6,2,9]
["S1635","Erythromycin","e7","L3900-05","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture","Microbiology","Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).",733.93,"114-07-8",{"v":147,"d":"147.00"},200.29,{"v":3,"d":"3.00"},4.09,"http://selleckchem.com/products/Erythromycin(E-Mycin).html","C37H67NO13","Free Base","E-Mycin","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O",1.792,8,3,7]
["S1636","Amphotericin B","f7","L3900-05","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture","Microbiology","Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.",924.08,"1397-89-3",{"v":22,"d":"22.00"},23.81,"<1","N/A","http://selleckchem.com/products/Amphotericin-B(Abelcet).html","C47H73NO17","free base","NSC 527017","CC1OC(OC/2CC3OC(O)(CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)OC(C)C(C)C(O)C(C)\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C2)CC(O)C3C(O)=O)C(O)C(N)C1O",-2.617,6,10,3]
["S1638","Ibuprofen (NSC 256857)","g7","L3900-05","in 10mM DMSO","COX","Neuronal Signaling","Ibuprofen (NSC 256857, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.",206.28,"15687-27-1",{"v":41,"d":"41.00"},198.76,"<1","N/A","http://selleckchem.com/products/Ibuprofen(Advil).html","C13H18O2","free base","Dolgesic,NSC 256857","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S1639","Amprenavir (VX-478)","h7","L3900-05","in 10mM DMSO","HIV Protease","Proteases","Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.",505.63,"161814-49-9",{"v":16,"d":"16.00"},31.64,"<1","N/A","http://selleckchem.com/products/Amprenavir-(Agenerase).html","C25H35N3O6S","free base","141W94, VX-478, KVX-478","CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)[S](=O)(=O)C3=CC=C(N)C=C3",2.429,5,3,12]
["S1640","Albendazole (SKF-62979)","a8","L3900-05","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.",265.33,"54965-21-8",{"v":17,"d":"17.00"},64.07,"<1","N/A","http://selleckchem.com/products/Albendazole(Albenza).html","C12H15N3O2S","free base","SKF-62979","CCCSC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",3.065,3,2,5]
["S1641","Chlorothiazide","b8","L3900-05","in 10mM DMSO","Others","Others","Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)",295.72,"58-94-6",{"v":59,"d":"59.00"},199.51,"<1","N/A","http://selleckchem.com/products/Chlorothiazide(Diuril).html","C7H6ClN3O4S2","free base","N/A","N[S](=O)(=O)C1=C(Cl)C=C2N=CN[S](=O)(=O)C2=C1",-0.177,5,2,1]
["S1643","Ursodiol","c8","L3900-05","in 10mM DMSO","FXR","GPCR & G Protein","Ursodiol (Ursodeoxycholic acid, UDCA) reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)",392.57,"128-13-2",{"v":79,"d":"79.00"},201.24,"<1","N/A","http://selleckchem.com/products/Ursodiol(Actigal).html","C24H40O4","free base","Ursodeoxycholic acid, UDCA","CC(CCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",4.014,1,2,4]
["S1645","Ketoprofen","d8","L3900-05","in 10mM DMSO","COX","Neuronal Signaling","Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.",254.28,"22071-15-4",{"v":51,"d":"51.00"},200.57,"<1","N/A","http://selleckchem.com/products/Ketoprofen(Actron).html","C16H14O3","free base","RP-19583","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S1646","Ketorolac","e8","L3900-05","in 10mM DMSO","COX","Neuronal Signaling","Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.",255.27,"74103-06-3",{"v":75,"d":"75.00"},293.81,"<1","N/A","http://selleckchem.com/products/Ketorolac-Tromethamine(Toradol).html","C15H13N1O3","free base","N/A","OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",2.832,2,0,3]
["S1647","Adenosine","f8","L3900-05","in 10mM DMSO","Adenosine Receptor,Nucleoside Analog/Antimetabolite","GPCR & G Protein","Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.",267.24,"58-61-7",{"v":12,"d":"12.00"},{"v":44.9,"d":"44.90"},"<1","N/A","http://selleckchem.com/products/Adenosine(Adenocard).html","C10H13N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-1.881,4,4,2]
["S1649","Zolmitriptan","g8","L3900-05","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Zolmitriptan(BW-311C90) is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.",287.36,"139264-17-8",{"v":58,"d":"58.00"},201.84,"<1","N/A","http://selleckchem.com/products/Zolmitriptan(Zomig).html","C16H21N3O2","free base","BW-311C90","CN(C)CCC1=C[NH]C2=C1C=C(CC3COC(=O)N3)C=C2",2.457,2,2,5]
["S1651","Telbivudine","h8","L3900-05","in 10mM DMSO","Reverse Transcriptase","Microbiology","Telbivudine(NV 02B) is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.",242.23,"3424-98-4",{"v":48,"d":"48.00"},198.16,{"v":48,"d":"48.00"},198.16,"http://selleckchem.com/products/Telbivudine(Sebivo).html","C10H14N2O5","free base","NV 02B","CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O",-1.238,3,3,2]
["S1653","Tretinoin (NSC 122758)","a9","L3900-05","in 10mM DMSO","Retinoid Receptor","Metabolism","Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.",{"v":300.4,"d":"300.40"},"302-79-4",{"v":60,"d":"60.00"},199.73,"<1","N/A","http://selleckchem.com/products/Tretinoin(Aberela).html","C20H28O2","free base","Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1655","Ezetimibe (SCH-58235)","b9","L3900-05","in 10mM DMSO","LDL","Metabolism","Ezetimibe (SCH-58235) is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.",{"v":409.4,"d":"409.40"},"163222-33-1",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/Ezetimibe(Zetia).html","C24H21F2NO3","free base","SCH-58235","OC(CCC1C(N(C1=O)C2=CC=C(F)C=C2)C3=CC=C(O)C=C3)C4=CC=C(F)C=C4",4.633,1,2,6]
["S1657","Enalaprilat Dihydrate","c9","L3900-05","in 10mM DMSO","RAAS","Endocrinology & Hormones","Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.",{"v":348.4,"d":"348.40"},"84680-54-6",{"v":70,"d":"70.00"},200.92,"<1","N/A","http://selleckchem.com/products/Enalaprilat.html","C18H24N2O5.2H2O","Dihydrate","MK-422 Dihydrate","O.O.CC(NC(CCC1=CC=CC=C1)C(O)=O)C(=O)N2CCCC2C(O)=O",{"v":-1.53,"d":"-1.530"},3,1,8]
["S1658","Dofetilide","d9","L3900-05","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Dofetilide (UK-68798) is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.",441.56,"115256-11-6",{"v":88,"d":"88.00"},199.29,"<1","N/A","http://selleckchem.com/products/Dofetilide(Tikosyn).html","C19H27N3O5S2","free base","UK-68798","CN(CCOC1=CC=C(N[S](C)(=O)=O)C=C1)CCC2=CC=C(N[S](C)(=O)=O)C=C2",1.679,5,2,11]
["S1662","Isradipine","e9","L3900-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Isradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.",371.39,"75695-93-1",{"v":74,"d":"74.00"},199.25,"<1","N/A","http://selleckchem.com/products/Isradipine(Dynacirc).html","C19H21N3O5","free base","PN 200-110","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC3=NON=C23)C(=O)OC(C)C)C",2.168,7,1,6]
["S1665","Estrone","f9","L3900-05","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estrone is an estrogenic hormone.",270.37,"53-16-7",{"v":54,"d":"54.00"},199.73,"<1","N/A","http://selleckchem.com/products/Estrone.html","C18H22O2","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2=O",3.938,1,1,0]
["S1666","Flucytosine","g9","L3900-05","in 10mM DMSO","Fungal","Microbiology","Flucytosine (5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915) is an antifungal drug with IC50 of 0.93 μM in C. albicans.",129.09,"2022-85-7",{"v":8,"d":"8.00"},61.97,{"v":5,"d":"5.00"},38.73,"http://selleckchem.com/products/Flucytosine(Ancobon).html","C4H4FN3O","free base","5-Fluorocytosine, 5-FC, NSC 103805, Ro 2-9915","NC1=NC(=O)NC=C1F",-1.048,2,2,0]
["S1667","Trichlormethiazide","h9","L3900-05","in 10mM DMSO","Others","Others","Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide.",380.66,"133-67-5",{"v":54,"d":"54.00"},141.86,"<1","N/A","http://selleckchem.com/products/Trichlormethiazide(Achletin).html","C8H8Cl3N3O4S2","free base","N/A","N[S](=O)(=O)C1=C(Cl)C=C2NC(N[S](=O)(=O)C2=C1)C(Cl)Cl",1.046,4,3,2]
["S1669","Loteprednol etabonate","a10","L3900-05","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.",466.95,"82034-46-6",{"v":93,"d":"93.00"},199.16,"<1","N/A","http://selleckchem.com/products/Loteprednol-etabonate.html","C24H31ClO7","free base","N/A","CCOC(=O)OC1(CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C)C(=O)OCCl",3.865,6,1,7]
["S1673","Aminophylline","b10","L3900-05","in 10mM DMSO","PDE","Metabolism","Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.",420.43,"317-34-0",{"v":53,"d":"53.00"},126.06,{"v":84,"d":"84.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Aminophylline(Truphylline).html","C16H24N10O4","Ethylenediamine","Phyllocontin","CN1C(=O)N(C)C2=C([NH]C=N2)C1=O.CN3C(=O)N(C)C4=C([NH]C=N4)C3=O.NCCN",-2.089,6,4,1]
["S1675","Lubiprostone","c10","L3900-05","in 10mM DMSO","Chloride Channel","Transmembrane Transporters","Lubiprostone (RU 0211,SPI-0211) is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.",390.46,"136790-76-6",{"v":78,"d":"78.00"},199.76,"<1","N/A","http://selleckchem.com/products/Lubiprostone(Amitiza).html","C20H32F2O5","Free Base","RU 0211,SPI-0211","CCCCC(F)(F)C(=O)CCC1C(O)CC(=O)C1CCCCCCC(O)=O",3.831,3,1,14]
["S1676","Amorolfine HCl","d10","L3900-05","in 10mM DMSO","Fungal","Microbiology","Amorolfine HCl(Ro 14-4767 HCl) is an antifungal reagent.",353.97,"78613-38-4",{"v":28,"d":"28.00"},{"v":79.1,"d":"79.10"},{"v":9,"d":"9.00"},25.43,"http://selleckchem.com/products/Amorolfine-Hydrochloride.html","C21H35NO.HCl","Hydrochloride","Ro 14-4767 HCl","Cl.CCC(C)(C)C1=CC=C(CC(C)CN2CC(C)OC(C)C2)C=C1",5.681,1,0,6]
["S1677","Chloramphenicol","e10","L3900-05","in 10mM DMSO","Antibiotics for Plant Cell Culture,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.",323.13,"56-75-7",{"v":65,"d":"65.00"},201.16,"<1","N/A","http://selleckchem.com/products/Chloramphenicol(Chloromycetin).html","C11H12Cl2N2O5","free base","Chloromycetin","OCC(NC(=O)C(Cl)Cl)C(O)C1=CC=C(C=C1)[N+]([O-])=O",1.025,1,3,6]
["S1679","Flurbiprofen","f10","L3900-05","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).",244.26,"5104-49-4",{"v":49,"d":"49.00"},200.61,"<1","N/A","http://selleckchem.com/products/Flurbiprofen(Ansaid).html","C15H13FO2","free base","N/A","CC(C(O)=O)C1=CC(=C(C=C1)C2=CC=CC=C2)F",{"v":3.68,"d":"3.680"},1,0,3]
["S1680","Disulfiram (NSC 190940)","g10","L3900-05","in 10mM DMSO","Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis","Metabolism","Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).",296.54,"97-77-8",{"v":59,"d":"59.00"},198.96,"<1","N/A","http://selleckchem.com/products/Disulfiram(Antabuse).html","C10H20N2S4","free base","NSC 190940, Tetraethylthiuram disulfide, TETD","CCN(CC)C(=S)SSC(=S)N(CC)CC",{"v":5.6,"d":"5.600"},0,0,9]
["S1681","Mesalamine (5-ASA)","h10","L3900-05","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK","NF-κB","Mesalamine (5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.",153.14,"89-57-6",{"v":31,"d":"31.00"},202.43,"<1","N/A","http://selleckchem.com/products/Mesalamine(Lialda).html","C7H7NO3","free base","5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa","NC1=CC=C(O)C(=C1)C(O)=O",0.471,1,2,1]
["S1683","Ipratropium Bromide","a11","L3900-05","in 10mM DMSO","AChR","Neuronal Signaling","Ipratropium Bromide is an antagonist of M3 type muscarinic acetylcholine receptors, used for the treatment of chronic obstructive pulmonary disease (COPD).",412.37,"22254-24-6",{"v":83,"d":"83.00"},201.28,{"v":83,"d":"83.00"},201.28,"http://selleckchem.com/products/Ipratropium-bromide.html","C20H30BrNO3","Bromide","N/A","[Br-].CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",-1.326,2,1,6]
["S1685","Sulfanilamide","b11","L3900-05","in 10mM DMSO","Bacterial","Microbiology","Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.",{"v":172.2,"d":"172.20"},"63-74-1",{"v":34,"d":"34.00"},197.44,"<1","N/A","http://selleckchem.com/products/Sulfanilamide.html","C6H8N2O2S","free base","N/A","NC1=CC=C(C=C1)[S](N)(=O)=O",-0.212,2,2,1]
["S1688","Betamethasone Dipropionate","c11","L3900-05","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.",504.59,"5593-20-4",{"v":100,"d":"100.00"},198.18,"<1","N/A","http://selleckchem.com/products/Betamethasone-Dipropionate(Diprolene).html","C28H37FO7","Free Base","SCH 11460","CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C",{"v":3.8,"d":"3.800"},6,1,8]
["S1690","Betamethasone Valerate","d11","L3900-05","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.",476.58,"2152-44-5",{"v":95,"d":"95.00"},199.34,"<1","N/A","http://selleckchem.com/products/Betamethasone-valerate(Betnovate).html","C27H37FO6","free base","N/A","CCCCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CO",3.666,4,2,7]
["S1691","Praziquantel","e11","L3900-05","in 10mM DMSO","COVID-19,Parasite","Microbiology","Praziquantel is an anthelmintic effective against flatworms.",312.41,"55268-74-1",{"v":63,"d":"63.00"},201.66,"<1","N/A","http://selleckchem.com/products/Praziquantel(Biltricide).html","C19H24N2O2","free base","N/A","O=C1CN(CC2N1CCC3=CC=CC=C23)C(=O)C4CCCCC4",2.477,2,0,1]
["S1692","Busulfan (NSC-750)","f11","L3900-05","in 10mM DMSO","Apoptosis related,DNA alkylator","DNA Damage/DNA Repair","Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.",{"v":246.3,"d":"246.30"},"55-98-1",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/Busulfan(Busulfex).html","C6H14O6S2","free base","NSC-750","C[S](=O)(=O)OCCCCO[S](C)(=O)=O",-0.289,2,0,7]
["S1693","Carbamazepine","g11","L3900-05","in 10mM DMSO","Autophagy,Sodium Channel","Transmembrane Transporters","Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.",236.27,"298-46-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/Carbamazepine(Carbatrol).html","C15H12N2O","free base","NSC 169864","NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",2.679,1,1,0]
["S1696","Hydrocortisone (NSC 10483)","h11","L3900-05","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.",362.46,"50-23-7",{"v":73,"d":"73.00"},{"v":201.4,"d":"201.40"},"<1","N/A","http://selleckchem.com/products/Hydrocortisone.html","C21H30O5","free base","Cortisol","CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)CO)C4(C)CC(O)C23",1.283,2,2,2]
["S1701","Desonide","a2","L3900-06","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Desonide is a low potency topical corticosteroid.",416.51,"638-94-8",{"v":83,"d":"83.00"},199.27,"<1","N/A","http://selleckchem.com/products/Desonide.html","C24H32O6","free base","N/A","CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(O1)C(=O)CO",1.028,4,2,2]
["S1702","Didanosine","b2","L3900-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.",236.23,"69655-05-6",{"v":47,"d":"47.00"},198.96,"<1","N/A","http://selleckchem.com/products/Didanosine(Videx).html","C10H12N4O3","free base","N/A","OCC1CCC(O1)[N]2C=NC3=C2N=CNC3=O",-0.844,4,2,2]
["S1703","Divalproex Sodium","c2","L3900-06","in 10mM DMSO","HDAC","Epigenetics","Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.",310.41,"76584-70-8",{"v":62,"d":"62.00"},199.74,{"v":62,"d":"62.00"},199.74,"http://selleckchem.com/products/Divalproex-sodium.html","C8H16O2.C8H15O2.Na","Sodium Salt","N/A","[Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O",4.025,1,0,10]
["S1704","Emtricitabine (BW 1592)","d2","L3900-06","in 10mM DMSO","HBV,HIV,Reverse Transcriptase","Microbiology","Emtricitabine (BW1592, FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor. Intracellular half-life is 39 h.",247.25,"143491-57-0",{"v":49,"d":"49.00"},198.18,{"v":49,"d":"49.00"},198.18,"http://selleckchem.com/products/Emtricitabine.html","C8H10FN3O3S","free base","FTC, BW1592","NC1=NC(=O)N(C=C1F)C2CSC(CO)O2",{"v":-0.68,"d":"-0.680"},3,2,2]
["S1705","Progesterone (NSC 9704)","e2","L3900-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Progesterone (NSC 9704, NSC 64377, Pregn-4-ene-3,20-dione) is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.",314.46,"57-83-0",{"v":22,"d":"22.00"},69.96,"<1","N/A","http://selleckchem.com/products/Progesterone(Prometrium).html","C21H30O2","free base","NSC 64377, Pregn-4-ene-3,20-dione,NSC 9704","CC(=O)C1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",{"v":3.86,"d":"3.860"},2,0,1]
["S1706","Lamivudine (BCH-189)","f2","L3900-06","in 10mM DMSO","COVID-19,Reverse Transcriptase","Microbiology","Lamivudine (BCH-189, GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.",229.26,"134678-17-4",{"v":46,"d":"46.00"},200.65,{"v":46,"d":"46.00"},200.65,"http://selleckchem.com/products/Lamivudine(Epivir).html","C8H11N3O3S","free base","GR109714X, BCH-189","NC1=NC(=O)N(C=C1)C2CSC(CO)O2",{"v":-0.59,"d":"-0.590"},3,2,2]
["S1709","Estradiol","g2","L3900-06","in 10mM DMSO","Estrogen/progestogen Receptor,Interleukins","Endocrinology & Hormones","Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.",272.38,"50-28-2",{"v":54,"d":"54.00"},198.25,"<1","N/A","http://selleckchem.com/products/Estradiol.html","C18H24O2","free base","17β-estradiol, β-Estradiol, E2, 17β-Oestradiol","CC12CCC3C(CCC4=C3C=CC(=C4)O)C1CCC2O",3.838,0,2,0]
["S1712","Deferasirox (ICL-670)","h2","L3900-06","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17)","Proteases","Deferasirox (ICL-670, CGP-72670) is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.",373.36,"201530-41-8",{"v":74,"d":"74.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Deferasirox(Exjade).html","C21H15N3O4","free base","CGP-72670, ICL-670","OC(=O)C1=CC=C(C=C1)[N]2N=C(N=C2C3=CC=CC=C3O)C4=CC=CC=C4O",4.063,3,2,4]
["S1713","Piroxicam","a3","L3900-06","in 10mM DMSO","COX","Neuronal Signaling","Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.",331.35,"36322-90-4",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/Piroxicam(Feldene).html","C15H13N3O4S","free base","CP 16171","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.501,4,2,2]
["S1714","Gemcitabine (LY-188011)","b3","L3900-06","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.",{"v":263.2,"d":"263.20"},"95058-81-4",{"v":52,"d":"52.00"},197.57,{"v":52,"d":"52.00"},197.57,"http://selleckchem.com/products/Gemcitabine(Gemzar).html","C9H11F2N3O4","Free Base","LY-188011, NSC 613327","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.394,3,3,2]
["S1715","Glipizide","c3","L3900-06","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glipizide (CP-28720,K 4024) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.",445.54,"29094-61-9",{"v":89,"d":"89.00"},199.76,"<1","N/A","http://selleckchem.com/products/Glipizide(Glucotrol).html","C21H27N5O4S","free base","CP-28720,K 4024","CC1=NC=C(N=C1)C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCCCC3",1.902,6,3,7]
["S1716","Glyburide (Glibenclamide)","d3","L3900-06","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.",{"v":494,"d":"494.00"},"10238-21-8",{"v":99,"d":"99.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/Glyburide(Diabeta).html","C23H28ClN3O5S","free base","Glibenclamide","COC1=C(C=C(Cl)C=C1)C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCCCC3",{"v":4.14,"d":"4.140"},5,3,8]
["S1717","Fomepizole","e3","L3900-06","in 10mM DMSO","Dehydrogenase","Metabolism","Fomepizole (4-methylpyrazole, Antizol, Antizol-Vet) is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.",{"v":82.1,"d":"82.10"},"7554-65-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/Fomepizole(Antizol).html","C4H6N2","free base","4-methylpyrazole, Antizol, Antizol-Vet","CC1=C[NH]N=C1",{"v":0.76,"d":"0.760"},1,1,0]
["S1718","Adefovir Dipivoxil (GS 0840)","f3","L3900-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).",501.47,"142340-99-6",{"v":100,"d":"100.00"},199.41,"<1","N/A","http://selleckchem.com/products/Adefovir-Dipivoxil(Preveon).html","C20H32N5O8P","free base","GS 0840","CC(C)(C)C(=O)OCO[P](=O)(COCC[N]1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C",1.666,10,1,15]
["S1719","Zalcitabine","g3","L3900-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).",211.22,"7481-89-2",{"v":7,"d":"7.00"},33.14,{"v":42,"d":"42.00"},198.84,"http://selleckchem.com/products/Zalcitabine.html","C9H13N3O3","free base","NSC 606170, Ro 24-2027/000","NC1=NC(=O)N(C=C1)C2CCC(CO)O2",-0.991,3,2,2]
["S1721","Azathioprine","h3","L3900-06","in 10mM DMSO","Rho","Cell Cycle","Azathioprine(BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.",277.26,"446-86-6",{"v":54,"d":"54.00"},194.76,"<1","N/A","http://selleckchem.com/products/Azathioprine(Azasan).html","C9H7N7O2S","free base","BW 57-322","C[N]1C=NC(=C1SC2=C3[NH]C=NC3=NC=N2)[N+]([O-])=O",1.071,4,1,3]
["S1723","Indomethacin (NSC-77541)","a4","L3900-06","in 10mM DMSO","COX","Neuronal Signaling","Indomethacin (NSC-77541, Indometacin) is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.",357.79,"53-86-1",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/Indomethacin(Indocid).html","C19H16ClNO4","free base","Indometacin,NSC-77541","COC1=CC=C2[N](C(=C(CC(O)=O)C2=C1)C)C(=O)C3=CC=C(Cl)C=C3",4.235,3,0,4]
["S1725","Terbinafine","b4","L3900-06","in 10mM DMSO","Fungal","Microbiology","Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.",291.43,"91161-71-6",{"v":58,"d":"58.00"},199.02,"<1","N/A","http://selleckchem.com/products/Terbinafine(Lamisil).html","C21H25N","Free Base","SF 86-327,TDT 067","CN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C12",5.335,0,0,6]
["S1727","Levonorgestrel","c4","L3900-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.",312.45,"797-63-7",{"v":45,"d":"45.00"},144.02,"<1","N/A","http://selleckchem.com/products/Levonorgestrel(Levonelle).html","C21H28O2","free base","D-Norgestrel","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S1729","Gemfibrozil","d4","L3900-06","in 10mM DMSO","PPAR","Metabolism","Gemfibrozil (CI-719) is an activator of peroxisome proliferator-activated receptor-alpha (PPARα), used for the treatment of hypercholesterolemia and hypertriglyceridemia.",250.33,"25812-30-0",{"v":50,"d":"50.00"},199.74,"<1","N/A","http://selleckchem.com/products/Gemfibrozil(Lopid).html","C15H22O3","free base","CI-719","CC1=CC(=C(C)C=C1)OCCCC(C)(C)C(O)=O",4.172,2,0,6]
["S1730","Indapamide","e4","L3900-06","in 10mM DMSO","Others","Others","Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.",365.83,"26807-65-8",{"v":73,"d":"73.00"},199.55,"<1","N/A","http://selleckchem.com/products/Indapamide(Lozol).html","C16H16ClN3O3S","free base","N/A","CC1CC2=C(C=CC=C2)N1NC(=O)C3=CC=C(Cl)C(=C3)[S](N)(=O)=O",2.664,3,2,3]
["S1732","Mitotane","f4","L3900-06","in 10mM DMSO","Others","Others","Mitotane (NCI-C04933), is an antineoplastic medication used in the treatment of adrenocortical carcinoma.",320.04,"53-19-0",{"v":64,"d":"64.00"},199.98,"<1","N/A","http://selleckchem.com/products/Mitotane(Lysodren).html","C14H10Cl4","free base","NCI-C04933","ClC(Cl)C(C1=CC=C(Cl)C=C1)C2=C(Cl)C=CC=C2",5.745,0,0,3]
["S1733","Methylprednisolone (NSC-19987)","g4","L3900-06","in 10mM DMSO","ACE,Apoptosis related,Autophagy,Glucocorticoid Receptor,Immunology & Inflammation related,Interleukins","Endocrinology & Hormones","Methylprednisolone (NSC-19987,U 7532) is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.",374.47,"83-43-2",{"v":75,"d":"75.00"},200.28,"<1","N/A","http://selleckchem.com/products/Methylprednisolone.html","C22H30O5","free base","NSC-19987,U 7532","CC1CC2C3CCC(O)(C(=O)CO)C3(C)CC(O)C2C4(C)C=CC(=O)C=C14",1.512,2,2,2]
["S1734","Meloxicam","h4","L3900-06","in 10mM DMSO","COX","Neuronal Signaling","Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.",{"v":351.4,"d":"351.40"},"71125-38-7",{"v":30,"d":"30.00"},85.37,"<1","N/A","http://selleckchem.com/products/Meloxicam(Mobic).html","C14H13N3O4S2","free base","N/A","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=C(C)S3",0.255,4,2,2]
["S1735","Mesna","a5","L3900-06","in 10mM DMSO","Others","Others","Mesna, a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.",164.18,"19767-45-4",{"v":33,"d":"33.00"},{"v":201,"d":"201.00"},{"v":7,"d":"7.00"},42.64,"http://selleckchem.com/products/Mesna(Uromitexan).html","C2H5NaO3S2","Sodium Salt","N/A","[Na+].[O-][S](=O)(=O)CCS",-2.227,0,0,2]
["S1736","Methocarbamol","b5","L3900-06","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.",241.24,"532-03-6",{"v":48,"d":"48.00"},198.97,{"v":2,"d":"2.00"},8.29,"http://selleckchem.com/products/Methocarbamol(Robaxin).html","C11H15NO5","free base","AHR 85","COC1=C(OCC(O)COC(N)=O)C=CC=C1",0.916,4,2,7]
["S1737","Prednisolone (NSC-9900)","c5","L3900-06","in 10mM DMSO","Glucocorticoid Receptor,Immunology & Inflammation related","Endocrinology & Hormones","Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.",360.44,"50-24-8",{"v":72,"d":"72.00"},199.76,"<1","N/A","http://selleckchem.com/products/Prednisolone(Hydroretrocortine).html","C21H28O5","Free Base","NSC-9900","CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO",{"v":1.26,"d":"1.260"},2,2,2]
["S1738","Telmisartan","d5","L3900-06","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.",514.62,"144701-48-4",{"v":13,"d":"13.00"},25.26,"<1","N/A","http://selleckchem.com/products/Telmisartan(Micardis).html","C33H30N4O2","free base","BIBR 277","CCCC1=NC2=C(C=C(C=C2C)C3=NC4=C(C=CC=C4)[N]3C)[N]1CC5=CC=C(C=C5)C6=CC=CC=C6C(O)=O",7.799,3,0,7]
["S1740","Guaifenesin","e5","L3900-06","in 10mM DMSO","Others","Others","Guaifenesin is an expectorant used to relieve chest congestion.",198.22,"93-14-1",{"v":40,"d":"40.00"},{"v":201.8,"d":"201.80"},{"v":25,"d":"25.00"},126.12,"http://selleckchem.com/products/Guaifenesin(Guaiphenesin).html","C10H14O4","free base","N/A","COC1=C(OCC(O)CO)C=CC=C1",0.747,2,2,5]
["S1741","Rifabutin (LM427)","f5","L3900-06","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.",{"v":847,"d":"847.00"},"72559-06-9",{"v":60,"d":"60.00"},70.84,"<1","N/A","http://selleckchem.com/products/Rifabutin(Mycobutin).html","C46H62N4O11","free base","LM427, Ansamycin","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=O)C(=C5NC6(CCN(CC6)CC(C)C)N=C45)NC(=O)/C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C",3.931,9,5,5]
["S1742","Nevirapine (NSC 641530)","g5","L3900-06","in 10mM DMSO","Reverse Transcriptase","Microbiology","Nevirapine (NSC 641530,NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.",{"v":266.3,"d":"266.30"},"129618-40-2",{"v":53,"d":"53.00"},199.02,"<1","N/A","http://selleckchem.com/products/Nevirapine(Viramune).html","C15H14N4O","free base","NSC 641530,NVP","CC1=CC=NC2=C1NC(=O)C3=C(N=CC=C3)N2C4CC4",2.293,3,1,1]
["S1743","Esomeprazole magnesium","h5","L3900-06","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.",713.12,"161973-10-0",{"v":143,"d":"143.00"},200.53,"<1","N/A","http://selleckchem.com/products/nexium-esomeprazole-magnesium.html","C34H36MgN6O6S2","Magnesium salt","NEXIUM","[Mg++].COC1=CC2=C([N-]C(=N2)[S](=O)CC3=C(C)C(=C(C)C=N3)OC)C=C1.COC4=CC5=C([N-]C(=N5)[S](=O)CC6=NC=C(C)C(=C6C)OC)C=C4",{"v":6.1,"d":"6.100"},10,0,10]
["S1744","Nicotinic Acid","a6","L3900-06","in 10mM DMSO","Vitamin","Metabolism","Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family.",123.11,"59-67-6",{"v":25,"d":"25.00"},203.07,{"v":2,"d":"2.00"},16.25,"http://selleckchem.com/products/Niacin(Nicotinic-acid).html","C6H5NO2","free base","N/A","OC(=O)C1=CC=CN=C1",0.309,2,0,1]
["S1747","Nimodipine","b6","L3900-06","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.",418.44,"66085-59-4",{"v":84,"d":"84.00"},200.75,"<1","N/A","http://selleckchem.com/products/Nimodipine(Nimotop).html","C21H26N2O7","free base","BAY E 9736","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C",2.361,5,1,10]
["S1748","Nisoldipine","c6","L3900-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.",388.41,"63675-72-9",{"v":77,"d":"77.00"},198.24,"<1","N/A","http://selleckchem.com/products/Nisoldipine(Sular).html","C20H24N2O6","free base","BAY K 5552","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC=C2[N+]([O-])=O)C(=O)OCC(C)C)C",2.958,4,1,8]
["S1754","Oxybutynin","d6","L3900-06","in 10mM DMSO","AChR","Neuronal Signaling","Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.",357.49,"5633-20-5",{"v":71,"d":"71.00"},198.61,"<1","N/A","http://selleckchem.com/products/Oxybutynin(Ditropan).html","C22H31NO3","Free Base","N/A","CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C2=CC=CC=C2",4.646,2,0,10]
["S1759","Pitavastatin (NK-104) calcium","e6","L3900-06","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1760","Rifapentine","f6","L3900-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.",877.03,"61379-65-5",{"v":100,"d":"100.00"},114.02,"<1","N/A","http://selleckchem.com/products/Rifapentine(Priftin).html","C47H64N4O12","free base","MDL473","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(CC5)C6CCCC6",4.664,8,6,6]
["S1762","Pyrazinamide","g6","L3900-06","in 10mM DMSO","Bacterial","Microbiology","Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.",123.11,"98-96-4",{"v":25,"d":"25.00"},203.07,{"v":12,"d":"12.00"},97.47,"http://selleckchem.com/products/Pyrazinamide(Pyrazinoic-acid-amide).html","C5H5N3O","free base","Pyrazinoic Acid Amide","NC(=O)C1=NC=CN=C1",-1.041,3,1,1]
["S1763","Quetiapine (ICI-204636) fumarate","h6","L3900-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Quetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.",883.09,"111974-72-2",{"v":36,"d":"36.00"},40.77,"<1","N/A","http://selleckchem.com/products/Quetiapine-fumarate(Seroquel).html","C46H54N6O8S2","Fumarate","ICI-204636 fumarate","OCCOCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=CC=C4.OCCOCCN5CCN(CC5)C6=NC7=CC=CC=C7SC8=C6C=CC=C8.OC(=O)\\C=C\\C(O)=O",-0.718,6,2,14]
["S1764","Rifampin (NSC-113926)","a7","L3900-06","in 10mM DMSO","Antibiotics for Plant Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Rifampin (NSC-113926, Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.",822.94,"13292-46-1",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Rifampin(Rifadin).html","C43H58N4O12","free base","Rimactane, Rifampicin,NSC-113926","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(C)CC5",3.262,8,6,5]
["S1768","Cefditoren Pivoxil","b7","L3900-06","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria.",620.72,"117467-28-4",{"v":100,"d":"100.00"},{"v":161.1,"d":"161.10"},"<1","N/A","http://selleckchem.com/products/Cefditoren-pivoxil.html","C25H28N6O7S3","free base","ME-1207","CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)\\C=C/C3=C(C)N=CS3)C4=CSC(=N4)N",1.926,10,2,12]
["S1770","Sulfadiazine","c7","L3900-06","in 10mM DMSO","Antibiotics","Microbiology","Sulfadiazine is a sulfonamide antibiotic.",250.28,"68-35-9",{"v":50,"d":"50.00"},199.78,"<1","N/A","http://selleckchem.com/products/Sulfadiazine.html","C10H10N4O2S","free base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NC2=NC=CC=N2",0.313,4,2,3]
["S1771","Chlorprothixene","d7","L3900-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Chlorprothixene(Minithixen,Truxal) has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.",315.86,"113-59-7",{"v":6,"d":"6.00"},{"v":19,"d":"19.00"},"<1","N/A","http://selleckchem.com/products/Chlorprothixene.html","C18H18ClNS","free base","Minithixen,Truxal","CN(C)CC/C=C1/C2=CC=CC=C2SC3=C1C=C(Cl)C=C3",5.123,0,0,3]
["S1773","Oxytetracycline (Terramycin)","e7","L3900-06","in 10mM DMSO","Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Others","Oxytetracycline(Terramycin) is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.",460.43,"79-57-2",{"v":92,"d":"92.00"},199.81,"<1","N/A","http://selleckchem.com/products/Oxytetracycline(Terramycin).html","C22H24N2O9","free base","Terramycin","CN(C)C1C2C(O)C3C(=C(O)C4=C(C=CC=C4O)C3(C)O)C(=O)C2(O)C(=O)C(=C1O)C(N)=O",-1.904,3,5,2]
["S1774","Thioguanine (NSC 752)","f7","L3900-06","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1775","Thiotepa","g7","L3900-06","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.",189.22,"52-24-4",{"v":100,"d":"100.00"},528.49,{"v":100,"d":"100.00"},528.49,"http://selleckchem.com/products/thiotepa-thioplex.html","C6H12N3PS","free base","Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide","S=[P](N1CC1)(N2CC2)N3CC3",-0.762,0,0,3]
["S1776","Toremifene Citrate (NK 622)","h7","L3900-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Toremifene Citrate (NK 622, NSC 613680) is an oral selective estrogen receptor modulator (SERM), used in the treatment of advanced breast cancer.",598.08,"89778-27-8",{"v":100,"d":"100.00"},{"v":167.2,"d":"167.20"},"<1","N/A","http://selleckchem.com/products/Toremifene-Citrate(Fareston).html","C32H36ClNO8","Citrate","NSC 613680,NK 622 Citrate","CN(C)CCOC1=CC=C(C=C1)\\C(=C(CCCl)/C2=CC=CC=C2)C3=CC=CC=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.945,4,0,14]
["S1777","Ethionamide","a8","L3900-06","in 10mM DMSO","Antibiotics","Microbiology","Ethionamide (Bayer 5312) is an antibiotic used in the treatment of tuberculosis.",166.24,"536-33-4",{"v":33,"d":"33.00"},198.51,"<1","N/A","http://selleckchem.com/products/Ethionamide.html","C8H10N2S","free base","Bayer 5312","CCC1=NC=CC(=C1)C(N)=S",1.498,1,1,2]
["S1778","Trifluridine (NSC 75520)","b8","L3900-06","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.",{"v":296.2,"d":"296.20"},"70-00-8",{"v":59,"d":"59.00"},199.19,{"v":59,"d":"59.00"},199.19,"http://selleckchem.com/products/Trifluridine(Viroptic).html","C10H11F3N2O5","free base","NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT","OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F",-0.782,3,3,3]
["S1782","Azacitidine (5-Azacytidine)","c8","L3900-06","in 10mM DMSO","Autophagy,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.",{"v":244.2,"d":"244.20"},"320-67-2",{"v":48,"d":"48.00"},196.56,"<1","N/A","http://selleckchem.com/products/Azacitidine(Vidaza).html","C8H12N4O5","free base","5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine","NC1=NC(=O)N(C=N1)C2OC(CO)C(O)C2O",-2.505,4,4,2]
["S1784","Vidarabine","d8","L3900-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.",267.24,"5536-17-4",{"v":53,"d":"53.00"},198.32,{"v":3,"d":"3.00"},11.23,"http://selleckchem.com/products/Vidarabine(Vira-A).html","C10H13N5O4","free base","N/A","NC1=C2N=C[N](C3OC(CO)C(O)C3O)C2=NC=N1",-1.881,4,4,2]
["S1786","Verteporfin (CL 318952)","e8","L3900-06","in 10mM DMSO","Apoptosis related,Autophagy,TEAD,VDA,YAP","Angiogenesis","Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.  It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.",718.79,"129497-78-5",{"v":100,"d":"100.00"},139.12,"<1","N/A","http://selleckchem.com/products/Verteporfin(Visudyne).html","C41H42N4O8","free base","CL 318952, Visudyne","COC(=O)CCC1=C(C)C2=CC3=NC(=CC4=C(C)C(=C([NH]4)C=C5N=C(C=C1[NH]2)C(=C5C)CCC(O)=O)C=C)C6=CC=C(C(C(=O)OC)C36C)C(=O)OC",7.789,9,2,12]
["S1787","Teniposide","f8","L3900-06","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Teniposide (NSC 122819, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).",656.65,"29767-20-2",{"v":40,"d":"40.00"},60.92,"<1","N/A","http://selleckchem.com/products/Teniposide(Vumon).html","C32H32O13S","free base","NSC 122819, VM-26","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(OC5C(O)C4O)C6=CC=CS6)C7=CC8=C(OCO8)C=C27",2.516,10,3,6]
["S1789","Tetrabenazine (Xenazine)","g8","L3900-06","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Tetrabenazine(Xenazine,Ro 1-9569) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2.",317.42,"58-46-8",{"v":58,"d":"58.00"},182.72,"<1","N/A","http://selleckchem.com/products/Tetrabenazine(Nitoman).html","C19H27NO3","free base","Xenazine,Ro 1-9569","COC1=CC2=C(C=C1OC)C3CC(=O)C(CC(C)C)CN3CC2",3.365,3,0,4]
["S1790","Rifaximin","h8","L3900-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.",785.88,"80621-81-4",{"v":47,"d":"47.00"},59.81,"<1","N/A","http://selleckchem.com/products/Rifaximin(Xifaxan).html","C43H51N3O11","free base","N/A","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=C(NC(=O)\\C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C5=C4N=C6C=C(C)C=C[N]56)O",4.805,8,5,3]
["S1792","Simvastatin (MK 733)","a9","L3900-06","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1793","Ramipril","b9","L3900-06","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Ramipril(HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.",416.51,"87333-19-5",{"v":83,"d":"83.00"},199.27,"<1","N/A","http://selleckchem.com/products/Ramipril(Altace).html","C23H32N2O5","free base","HOE-498","CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(O)=O",0.308,4,1,10]
["S1794","Fenofibrate (NSC-281319)","c9","L3900-06","in 10mM DMSO","Autophagy,P450 (e.g. CYP17),PPAR","Metabolism","Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.",360.83,"49562-28-9",{"v":72,"d":"72.00"},199.54,"<1","N/A","http://selleckchem.com/products/Fenofibrate(Tricor).html","C20H21ClO4","free base","NSC-281319","CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2",5.111,4,0,7]
["S1799","Ranolazine","d9","L3900-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine (CVT 303, RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.",427.54,"95635-55-5",{"v":86,"d":"86.00"},201.15,"<1","N/A","http://selleckchem.com/products/Ranolazine(Ranexa).html","C24H33N3O4","Free Base","CVT 303, RS 43285-003","COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",2.991,3,2,9]
["S1801","Ranitidine Hydrochloride","e9","L3900-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.",350.86,"66357-59-3",{"v":70,"d":"70.00"},199.51,{"v":70,"d":"70.00"},199.51,"http://selleckchem.com/products/Ranitidine-hydrochloride(Zantac).html","C13H22N4O3S.HCl","Hydrochloride","AH19065","Cl.CNC(/NCCSCC1=CC=C(CN(C)C)O1)=C\\[N+]([O-])=O",1.421,1,2,10]
["S1802","AICAR (Acadesine)","f9","L3900-06","in 10mM DMSO","AMPK,Mitophagy","PI3K/Akt/mTOR","AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.",258.23,"2627-69-2",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Acadesine.html","C9H14N4O5","free base","NSC105823, AICA Riboside","NC(=O)C1=C(N)[N](C=N1)C2OC(CO)C(O)C2O",-2.913,3,5,3]
["S1806","Acipimox","g9","L3900-06","in 10mM DMSO","Others","Others","Acipimox (Olbemox,K-9321) is a niacin derivative used as a hypolipidemic agent.",154.12,"51037-30-0",{"v":31,"d":"31.00"},201.14,"<1","N/A","http://selleckchem.com/products/Acipimox.html","C6H6N2O3","free base","Olbemox,K-9321","CC1=CN=C(C=[N+]1[O-])C(O)=O",-0.975,2,0,1]
["S1807","Aciclovir (BW 248U)","h9","L3900-06","in 10mM DMSO","Antiviral,Apoptosis related,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","Microbiology","Acyclovir (Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011,BW 248U) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.",{"v":225.2,"d":"225.20"},"59277-89-3",{"v":45,"d":"45.00"},199.82,"<1","N/A","http://selleckchem.com/products/Acyclovir(Aciclovir).html","C8H11N5O3","free base","Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011,BW 248U","NC1=NC2=C(N=C[N]2COCCO)C(=O)N1",-1.423,4,3,4]
["S1808","Nifedipine (BAY-a-1040)","a10","L3900-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.",346.33,"21829-25-4",{"v":69,"d":"69.00"},199.23,"<1","N/A","http://selleckchem.com/products/Nifedipine(Adalat).html","C17H18N2O6","free base","BAY-a-1040","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC)C",1.766,4,1,6]
["S1811","Amiloride (MK-870) HCl","b10","L3900-06","in 10mM DMSO","Calcium Channel,Serine Protease,Sodium Channel","Transmembrane Transporters","Amiloride (MK-870 HCl) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).",266.09,"2016-88-8",{"v":53,"d":"53.00"},199.18,{"v":6,"d":"6.00"},22.55,"http://selleckchem.com/products/Amiloride-hydrochloride(Midamor).html","C6H8ClN7O.HCl","Hydrochloride","MK-870 HCl","Cl.NC(=N)NC(=O)C1=NC(=C(N)N=C1N)Cl",-0.366,3,4,2]
["S1813","Amlodipine Besylate","c10","L3900-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",567.05,"111470-99-6",{"v":113,"d":"113.00"},199.28,"<1","N/A","http://selleckchem.com/products/Amlodipine-besylate(Norvasc).html","C20H25ClN2O5.C6H6O3S","Besylate","N/A","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C.O[S](=O)(=O)C3=CC=CC=C3",2.739,5,2,11]
["S1816","Chlorpheniramine Maleate","d10","L3900-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Chlorpheniramine Maleate (Chlorpheniramine maleate, Chlorphenamine, NCI-C55265) is an histamine H1 receptor antagonist with IC50 of 12 nM.",390.86,"113-92-8",{"v":78,"d":"78.00"},199.56,{"v":78,"d":"78.00"},199.56,"http://selleckchem.com/products/Chlorpheniramine-maleate.html","C16H19ClN2.C4H4O4","Maleate","NCI-C55265","CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":0.7,"d":"0.700"},3,0,7]
["S1825","Erdosteine","e10","L3900-06","in 10mM DMSO","NF-κB","NF-κB","Erdosteine (KW-9144,RV 144) is a mucolytic which is used in treatment of excessive viscous mucus. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation.",249.31,"84611-23-4",{"v":50,"d":"50.00"},200.55,"<1","N/A","http://selleckchem.com/products/erdosteine.html","C8H11NO4S2","free base","KW-9144,RV 144","OC(=O)CSCC(=O)NC1CCSC1=O",-0.382,3,1,5]
["S1827","Betaxolol HCl","f10","L3900-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Betaxolol (SL 75212) is a β1 adrenergic receptor blocker with IC50 of 6 μM.",343.89,"63659-19-8",{"v":69,"d":"69.00"},200.65,{"v":69,"d":"69.00"},200.65,"http://selleckchem.com/products/betaxolol-hydrochloride-betoptic.html","C18H29NO3.HCl","Hydrochloride","SL 75212 HCl","Cl.CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1",2.959,2,2,11]
["S1828","Proparacaine HCl","g10","L3900-06","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.",330.85,"5875-06-9",{"v":12,"d":"12.00"},36.27,{"v":66,"d":"66.00"},199.49,"http://selleckchem.com/products/proparacaine-hcl.html","C16H26N2O3.HCl","Hydrochloride","Proxymetacaine Hydrochloride","Cl.CCCOC1=C(N)C=C(C=C1)C(=O)OCCN(CC)CC",3.013,3,1,10]
["S1829","Pranlukast","h10","L3900-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Pranlukast (ONO-1078,ono-rs-411) is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.",{"v":481.5,"d":"481.50"},"103177-37-3",{"v":11,"d":"11.00"},22.85,"<1","N/A","http://selleckchem.com/products/pranlukast.html","C27H23N5O4","free base","ONO-1078,ono-rs-411","O=C(NC1=CC2=C(C=C1)C(=O)C=C(O2)C3=NN=N[NH]3)C4=CC=C(OCCCCC5=CC=CC=C5)C=C4",4.232,7,2,9]
["S1830","Oxfendazole","a11","L3900-06","in 10mM DMSO","Parasite","Microbiology","Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.",315.35,"53716-50-0",{"v":10,"d":"10.00"},31.71,"<1","N/A","http://selleckchem.com/products/oxfendazole.html","C15H13N3O3S","free base","RS-8858,Fenbendazole sulfoxide","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)[S](=O)C3=CC=CC=C3",2.657,4,2,4]
["S1831","Carvedilol","b11","L3900-06","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.",406.47,"72956-09-3",{"v":81,"d":"81.00"},199.28,"<1","N/A","http://selleckchem.com/products/carvedilol.html","C24H26N2O4","free base","BM-14190, SKF 105517","COC1=CC=CC=C1OCCNCC(O)COC2=C3C(=CC=C2)[NH]C4=C3C=CC=C4",4.014,3,3,10]
["S1832","Atracurium Besylate","c11","L3900-06","in 10mM DMSO","AChR","Neuronal Signaling","Atracurium Besylate (BW 33A, 51W89) is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.",1243.48,"64228-81-5",{"v":100,"d":"100.00"},80.42,{"v":33,"d":"33.00"},26.54,"http://selleckchem.com/products/atracurium-besylate.html","C53H72N2O12.2(C6H5O3S)","Dibesylate","BW 33A, 51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S1833","Butoconazole nitrate","d11","L3900-06","in 10mM DMSO","Fungal,IFN,Interleukins,TNF-alpha","Microbiology","Butoconazole nitrate (RS-35887) is an anti-fungal agent that inhibits PHA-stimulated release of cytokines-- IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively).",474.79,"64872-77-1",{"v":95,"d":"95.00"},200.09,"<1","N/A","http://selleckchem.com/products/butoconazole-nitrate.html","C19H17Cl3N2S.HNO3","Nitrate","RS-35887","O[N+]([O-])=O.ClC1=CC=C(CCC(C[N]2C=CN=C2)SC3=C(Cl)C=CC=C3Cl)C=C1",5.238,1,0,7]
["S1835","Azithromycin (CP-62993)","e11","L3900-06","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Autophagy,Bacterial,COVID-19","Autophagy","Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.",748.98,"83905-01-5",{"v":100,"d":"100.00"},133.51,"<1","N/A","http://selleckchem.com/products/azithromycin-zithromax.html","C38H72N2O12","Free Base","XZ-450,CP-62993","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",2.078,7,3,7]
["S1840","Lomustine","f11","L3900-06","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.",{"v":233.7,"d":"233.70"},"13010-47-4",{"v":46,"d":"46.00"},196.83,"<1","N/A","http://selleckchem.com/products/Lomustine(CeeNU).html","C9H16ClN3O2","free base","NSC79037, Gleostine, CeeNU, CCNU","ClCCN(N=O)C(=O)NC1CCCCC1",2.394,2,1,4]
["S1843","Chenodeoxycholic Acid","g11","L3900-06","in 10mM DMSO","FXR","Metabolism","Chenodeoxycholic Acid (Chenodiol, Chenodesoxycholic acid, Chenocholic acid,CDCA) is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.",392.57,"474-25-9",{"v":79,"d":"79.00"},201.24,"<1","N/A","http://selleckchem.com/products/Chenodeoxycholic-acid.html","C24H40O4","free base","Chenodiol, Chenodesoxycholic acid, Chenocholic acid,CDCA","CC(CCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",4.014,1,2,4]
["S1845","Cimetidine","h11","L3900-06","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cimetidine (SKF-92334), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.",252.34,"51481-61-9",{"v":51,"d":"51.00"},202.11,"<1","N/A","http://selleckchem.com/products/Cimetidine(Tagamet).html","C10H16N6S","free base","SKF-92334","CNC(NCCSCC1=C(C)[NH]C=N1)=NC#N",0.007,2,3,7]
["S1847","Clemastine (HS-592) fumarate","a2","L3900-07","in 10mM DMSO","Autophagy,Histamine Receptor,mTOR","Neuronal Signaling","Clemastine Fumarate (HS-592, Meclastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Clemastine stimulates autophagy via mTOR pathway.",459.96,"14976-57-9",{"v":35,"d":"35.00"},76.09,"<1","N/A","http://selleckchem.com/products/Clemastine-Fumarate.html","C21H26ClNO.C4H4O4","Fumarate","HS-592 fumarate, Meclastine fumarate","CN1CCCC1CCOC(C)(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.OC(=O)\\C=C\\C(O)=O",{"v":1.81,"d":"1.810"},3,0,8]
["S1848","Curcumin","b2","L3900-07","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S1849","Daidzein","c2","L3900-07","in 10mM DMSO","PPAR","Metabolism","Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.",254.24,"486-66-8",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Daidzein.html","C15H10O4","free base","N/A","OC1=CC=C(C=C1)C2=COC3=CC(=CC=C3C2=O)O",2.382,2,2,1]
["S1854","Bifonazole","d2","L3900-07","in 10mM DMSO","Fungal","Microbiology","Bifonazole (Bay h 4502,(±)-bifonazole) is a substituted imidazole antifungal agent.",310.39,"60628-96-8",{"v":62,"d":"62.00"},199.75,"<1","N/A","http://selleckchem.com/products/bifonazole.html","C22H18N2","free base","Bay h 4502,(±)-bifonazole","C1=CC=C(C=C1)C([N]2C=CN=C2)C3=CC=C(C=C3)C4=CC=CC=C4",4.637,1,0,4]
["S1856","Metoprolol Tartrate","e2","L3900-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Metoprolol Tartrate (CGP 2175E) is a selective β1 receptor blocker medication, used to treat hypertension and heart failure.",684.81,"56392-17-7",{"v":100,"d":"100.00"},146.03,{"v":100,"d":"100.00"},146.03,"http://selleckchem.com/products/metoprolol-tartrate.html","2C15H25NO3.C4H6O6","Tartrate","CGP 2175E","COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC2=CC=C(OCC(O)CNC(C)C)C=C2.OC(C(O)C(O)=O)C(O)=O",-3.559,6,6,21]
["S1859","Diethylstilbestrol","f2","L3900-07","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Diethylstilbestrol (Stilbestrol) is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.",268.35,"56-53-1",{"v":54,"d":"54.00"},201.23,"<1","N/A","http://selleckchem.com/products/Diethylstilbestrol(Stilbestrol).html","C18H20O2","free base","Stilbestrol","CCC(/C1=CC=C(O)C=C1)=C(CC)\\C2=CC=C(O)C=C2",5.137,0,2,4]
["S1865","Diltiazem HCl","g2","L3900-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.",450.98,"33286-22-5",{"v":90,"d":"90.00"},199.57,{"v":90,"d":"90.00"},199.57,"http://selleckchem.com/products/Diltiazem-HCl(Tiazac).html","C22H26N2O4S.HCl","Hydrochloride","RG 83606 HCl","Cl.COC1=CC=C(C=C1)C2SC3=C(C=CC=C3)N(CCN(C)C)C(=O)C2OC(C)=O",3.475,4,0,7]
["S1866","Diphenhydramine HCl","h2","L3900-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Diphenhydramine HCl is a first-generation histamine H1 receptor antagonist, used in various allergic conditions such as rhinitis, urticaria and conjunctivitis.",291.82,"147-24-0",{"v":58,"d":"58.00"},198.75,{"v":58,"d":"58.00"},198.75,"http://selleckchem.com/products/Diphenhydramine-hydrochloride(Benadryl).html","C17H21NO.HCl","Hydrochloride","N/A","Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2",3.766,1,0,6]
["S1869","Dapoxetine HCl","a3","L3900-07","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.",341.87,"129938-20-1",{"v":68,"d":"68.00"},198.91,{"v":68,"d":"68.00"},198.91,"http://selleckchem.com/products/Dapoxetine-hydrochloride(Priligy).html","C21H23NO.HCl","Hydrochloride","LY-210448","Cl.CN(C)C(CCOC1=C2C=CC=CC2=CC=C1)C3=CC=CC=C3",4.917,1,0,6]
["S1876","Valaciclovir HCl","b3","L3900-07","in 10mM DMSO","CMV","Microbiology","Valaciclovir HCl, an aciclovir prodrug, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV).",{"v":360.8,"d":"360.80"},"124832-27-5",{"v":14,"d":"14.00"},{"v":38.8,"d":"38.80"},{"v":72,"d":"72.00"},199.56,"http://selleckchem.com/products/valaciclovir-hcl.html","C13H20N6O4.HCl","Hydrochloride","N/A","Cl.CC(C)C(N)C(=O)OCCOC[N]1C=NC2=C1N=C(N)NC2=O",-0.296,6,3,8]
["S1878","Ganciclovir (BW 759)","c3","L3900-07","in 10mM DMSO","CMV","Microbiology","Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.",255.23,"82410-32-0",{"v":27,"d":"27.00"},105.79,"<1","N/A","http://selleckchem.com/products/ganciclovir.html","C9H13N5O4","free base","RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine","NC1=NC2=C(N=C[N]2COC(CO)CO)C(=O)N1",-1.934,4,4,5]
["S1883","Idoxuridine","d3","L3900-07","in 10mM DMSO","Antiviral","Microbiology","Idoxuridine (NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.",{"v":354.1,"d":"354.10"},"54-42-2",{"v":35,"d":"35.00"},98.84,"<1","N/A","http://selleckchem.com/products/idoxuridine.html","C9H11IN2O5","free base","NSC 39661, SKF 14287,5-Iodo-2′-deoxyuridine,5-IUdR,IdUrd","OCC1OC(CC1O)N2C=C(I)C(=O)NC2=O",-1.402,3,3,2]
["S1884","Sparfloxacin","e3","L3900-07","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sparfloxacin (AT-4140, CI-978, PD 131501,Zagam) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.",{"v":392.4,"d":"392.40"},"110871-86-8",{"v":9,"d":"9.00"},22.94,"<1","N/A","http://selleckchem.com/products/sparfloxacin.html","C19H22F2N4O3","free base","AT-4140, CI-978, PD 131501,Zagam","CC1CN(CC(C)N1)C2=C(F)C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(O)=O",-1.056,2,2,3]
["S1885","Felodipine","f3","L3900-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Felodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.",384.25,"72509-76-3",{"v":77,"d":"77.00"},200.39,"<1","N/A","http://selleckchem.com/products/Felodipine(Plendil).html","C18H19Cl2NO4","free base","CGH-869","CCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",3.549,4,1,6]
["S1888","Deflazacort","g3","L3900-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.",441.52,"14484-47-0",{"v":88,"d":"88.00"},199.31,"<1","N/A","http://selleckchem.com/products/Deflazacor.html","C25H31NO6","free base","MDL 458","CC(=O)OCC(=O)C12N=C(C)OC1CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC23C",{"v":1.67,"d":"1.670"},6,1,4]
["S1890","Nizatidine","h3","L3900-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.",331.46,"76963-41-2",{"v":66,"d":"66.00"},199.12,{"v":28,"d":"28.00"},84.47,"http://selleckchem.com/products/Nizatidine(Axid).html","C12H21N5O2S2","free base","N/A","CNC(/NCCSCC1=CSC(=N1)CN(C)C)=C/[N+]([O-])=O",0.643,1,2,10]
["S1891","Carbidopa","a4","L3900-07","in 10mM DMSO","Decarboxylase","Metabolism","Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.",226.23,"28860-95-9",{"v":4,"d":"4.00"},17.68,"<1","N/A","http://selleckchem.com/products/Carbidopa.html","C10H14N2O4","free base","N/A","CC(CC1=CC(=C(O)C=C1)O)(NN)C(O)=O",0.364,1,4,4]
["S1894","Valsartan (CGP-48933)","b4","L3900-07","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.",435.52,"137862-53-4",{"v":87,"d":"87.00"},199.76,"<1","N/A","http://selleckchem.com/products/Valsartan(Diovan).html","C24H29N5O3","free base","CGP-48933","CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=N[NH]N=N3)C(C(C)C)C(O)=O",4.538,5,1,10]
["S1895","Dipyridamole (NSC 515776)","c4","L3900-07","in 10mM DMSO","PDE","Metabolism","Dipyridamole (NSC-515776, Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.",504.63,"58-32-2",{"v":101,"d":"101.00"},200.15,"<1","N/A","http://selleckchem.com/products/Dipyridamole(Permole,-Persantine).html","C24H40N8O4","free base","Persantine,NSC-515776","OCCN(CCO)C1=NC2=C(N=C(N=C2N3CCCCC3)N(CCO)CCO)C(=N1)N4CCCCC4",2.483,4,4,12]
["S1896","Hydroxyurea (NSC-32065)","d4","L3900-07","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,HIV","DNA Damage/DNA Repair","Hydroxyurea (NSC-32065, NCI-C04831, Hydroxycarbamide) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.",76.05,"127-07-1",{"v":15,"d":"15.00"},197.24,{"v":15,"d":"15.00"},197.24,"http://selleckchem.com/products/Hydroxyurea(Cytodrox).html","CH4N2O2","free base","NCI-C04831, Hydroxycarbamide,NSC-32065","NC(=O)NO",{"v":-1.03,"d":"-1.030"},1,2,0]
["S1897","Potassium Iodide","e4","L3900-07","in 10mM DMSO","Others","Others","Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.",{"v":166,"d":"166.00"},"7681-11-0",{"v":33,"d":"33.00"},{"v":198.8,"d":"198.80"},{"v":33,"d":"33.00"},{"v":198.8,"d":"198.80"},"http://selleckchem.com/products/Potassium-iodide.html","K+I-","Inorganic salt","N/A","[K+].[I-]",-3.113,0,0,0]
["S1898","Tropisetron HCl","f4","L3900-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tropisetron HCl (ICS 205-930) is a potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist, used to treat nausea and vomiting following chemotherapy.",320.81,"105826-92-4",{"v":35,"d":"35.00"},{"v":109.1,"d":"109.10"},{"v":46,"d":"46.00"},143.39,"http://selleckchem.com/products/Tropisetron-hydrochloride.html","C17H20N2O2.HCl","Hydrochloride","ICS 205-930","Cl.CN1C2CCC1CC(C2)OC(=O)C3C=NC4=CC=CC=C34",2.366,3,0,3]
["S1899","Nicotinamide (NSC 13128)","g4","L3900-07","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide (Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.",122.12,"98-92-0",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/Nicotinamide(Niacinamide).html","C6H6N2O","free base","Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128","NC(=O)C1=CC=CN=C1",-0.319,2,1,1]
["S1903","Diclofenac Sodium","h4","L3900-07","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac Sodium (GP 45840) is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.",318.13,"15307-79-6",{"v":64,"d":"64.00"},201.18,{"v":14,"d":"14.00"},44.01,"http://selleckchem.com/products/Diclofenac-sodium.html","C14H10Cl2NNaO2","Sodium Salt","GP 45840","[Na+].[O-]C(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",2.899,0,1,4]
["S1905","Amlodipine","a5","L3900-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",408.88,"88150-42-9",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Amlodipine(Norvasc).html","C20H25ClN2O5","free base","UK-48340","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C",1.576,5,2,10]
["S1907","Metronidazole","b5","L3900-07","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.",171.15,"443-48-1",{"v":34,"d":"34.00"},198.66,"<1","N/A","http://selleckchem.com/products/Metronidazole(Flagyl).html","C6H9N3O3","free base","N/A","CC1=NC=C([N]1CCO)[N+]([O-])=O",-0.337,1,1,3]
["S1908","Flutamide","c5","L3900-07","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.",276.21,"13311-84-7",{"v":55,"d":"55.00"},199.12,"<1","N/A","http://selleckchem.com/products/Flutamide(Eulexin).html","C11H11F3N2O3","free base","SCH-13521","CC(C)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F",2.916,1,1,4]
["S1909","Fluvastatin (XU-62-320) Sodium","d5","L3900-07","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Fluvastatin Sodium (Vastin,XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.",433.45,"93957-55-2",{"v":87,"d":"87.00"},200.72,{"v":1,"d":"1.00"},2.31,"http://selleckchem.com/products/Fluvastatin-Sodium(Lescol).html","C24H25FNNaO4","Sodium","Vastin,XU-62-320","[Na+].CC(C)[N]1C2=C(C=CC=C2)C(=C1\\C=C\\C(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3",{"v":2.77,"d":"2.770"},0,2,8]
["S1913","Tropicamide","e5","L3900-07","in 10mM DMSO","AChR","Neuronal Signaling","Tropicamide(Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.",284.35,"1508-75-4",{"v":57,"d":"57.00"},200.46,"<1","N/A","http://selleckchem.com/products/tropicamide.html","C17H20N2O2","free base","Ro 1-7683","CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2",1.432,2,1,6]
["S1914","Pregnenolone","f5","L3900-07","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.",316.48,"145-13-1",{"v":22,"d":"22.00"},69.51,"<1","N/A","http://selleckchem.com/products/pregnenolone.html","C21H32O2","free base","3β-Hydroxy-5-pregnen-20-one","CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C",3.624,1,1,1]
["S1915","Sulfamethoxazole","g5","L3900-07","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sulfamethoxazole(Ro 4-2130) is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.",253.28,"723-46-6",{"v":51,"d":"51.00"},201.36,"<1","N/A","http://selleckchem.com/products/Sulfamethoxazole.html","C10H11N3O3S","free base","Ro 4-2130","CC1=CC(=NO1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.709,4,2,3]
["S1920","Haloperidol","h5","L3900-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Haloperidol (Haldol) is an antipsychotic and butyrophenone.",375.86,"52-86-8",{"v":75,"d":"75.00"},199.54,"<1","N/A","http://selleckchem.com/products/Haloperidol(Haldol).html","C21H23ClFNO2","free base","N/A","OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3",3.887,1,0,6]
["S1921","Phenindione","a6","L3900-07","in 10mM DMSO","Vitamin","Metabolism","Phenindione (Rectadione, phenylindandione) is an anticoagulant which functions as a Vitamin K antagonist.",222.24,"83-12-5",{"v":44,"d":"44.00"},197.98,"<1","N/A","http://selleckchem.com/products/Phenindione(Rectadione).html","C15H10O2","free base","Rectadione, phenylindandione","O=C1C(C2=CC=CC=C2)C(=O)C3=CC=CC=C13",2.819,2,0,1]
["S1933","Triamcinolone","b6","L3900-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.",394.43,"124-94-7",{"v":78,"d":"78.00"},197.75,"<1","N/A","http://selleckchem.com/products/Triamcinolone(Aristocort).html","C21H27FO6","free base","N/A","CC12CC(O)C3(F)C(CCC4=CC(=O)C=CC34C)C1CC(O)C2(O)C(=O)CO",0.422,2,3,2]
["S1934","Nystatin (Fungicidin)","c6","L3900-07","in 10mM DMSO","Antibiotics for Mammalian Cell Culture,Fungal","Microbiology","Nystatin(Fungicidin), which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.",1056.24,"62997-67-5",{"v":19,"d":"19.00"},17.99,"<1","N/A","http://selleckchem.com/products/Nystatin(Mycostatin).html","C53H85NO20","free base","Fungicidin","CC1OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)CC2(O)CC(O)C(C(CC(OC3OC(C)C(O)C(N)C3O)/C=C/C=C/C=C/C=C/CC/C=C/C=C/C(C)C(O)C1C)O2)C(O)=O",-2.265,8,11,5]
["S1937","Isoniazid","d6","L3900-07","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.",137.14,"54-85-3",{"v":27,"d":"27.00"},196.88,{"v":27,"d":"27.00"},196.88,"http://selleckchem.com/products/Isoniazid(Tubizid).html","C6H7N3O","free base","N/A","NNC(=O)C1=CC=NC=C1",-0.811,2,2,1]
["S1940","Levofloxacin","e6","L3900-07","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.",361.37,"100986-85-4",{"v":24,"d":"24.00"},66.41,{"v":11,"d":"11.00"},30.44,"http://selleckchem.com/products/levofloxacin-levaquin.html","C18H20FN3O4","Free Base","Fluoroquinolone","CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F",-1.374,3,0,2]
["S1941","Enalapril Maleate","f6","L3900-07","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.",492.52,"76095-16-4",{"v":99,"d":"99.00"},201.01,"<1","N/A","http://selleckchem.com/products/Enalapril-maleate(Vasotec).html","C20H28N2O5.C4H4O4","Maleate","MK-421 Maleate","CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(O)=O.OC(=O)\\C=C/C(O)=O",-0.502,6,1,12]
["S1949","Menadione (NSC 4170)","g6","L3900-07","in 10mM DMSO","CDK,DNA/RNA Synthesis,phosphatase","Metabolism","Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.",172.18,"58-27-5",{"v":34,"d":"34.00"},197.47,"<1","N/A","http://selleckchem.com/products/Menadione.html","C11H8O2","free base","Vitamin K3,NSC 4170","CC1=CC(=O)C2=CC=CC=C2C1=O",2.204,2,0,0]
["S1950","Metformin HCl","h6","L3900-07","in 10mM DMSO","Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK","Metabolism","Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",165.62,"1115-70-4",{"v":33,"d":"33.00"},199.25,{"v":33,"d":"33.00"},199.25,"http://selleckchem.com/products/Metformin-hydrochloride(Glucophage).html","C4H11N5.HCl","Hydrochloride","1,1-Dimethylbiguanide HCl","Cl.CN(C)C(=N)NC(N)=N",{"v":-0.36,"d":"-0.360"},0,2,3]
["S1952","Methoxsalen","a7","L3900-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.",216.19,"298-81-7",{"v":43,"d":"43.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Methoxsalen(Oxsoralen).html","C12H8O4","free base","Xanthotoxin, NCI-C55903","COC1=C2OC=CC2=CC3=C1OC(=O)C=C3",2.187,4,0,1]
["S1956","Miconazole Nitrate","b7","L3900-07","in 10mM DMSO","Fungal","Microbiology","Miconazole (NSC 169434) Nitrate is an imidazole antifungal agent by inhibiting ergosterol biosynthesis and inducing ROS, used to treat vaginal yeast infections.",479.14,"22832-87-7",{"v":96,"d":"96.00"},200.36,"<1","N/A","http://selleckchem.com/products/Miconazole-nitrate.html","C18H14Cl4N2O.HNO3","Nitrate","NSC 169434 Nitrate","O[N+]([O-])=O.ClC1=CC=C(COC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C(=C1)Cl",4.387,2,0,6]
["S1958","Sulbactam","c7","L3900-07","in 10mM DMSO","Anti-infection","Microbiology","Sulbactam(CP45899) is a beta-lactamase inhibitor with an average IC50 of 0.8 μM.",233.24,"68373-14-8",{"v":47,"d":"47.00"},201.51,{"v":47,"d":"47.00"},201.51,"http://selleckchem.com/products/sulbactam.html","C8H11NO5S","free base","CP45899","CC1(C)C(N2C(CC2=O)[S]1(=O)=O)C(O)=O",-0.671,4,0,1]
["S1959","Tolfenamic Acid","d7","L3900-07","in 10mM DMSO","COX","Neuronal Signaling","Tolfenamic Acid(Clotam) is a COX-2 inhibitor with IC50 of 0.2 μM.",{"v":261.7,"d":"261.70"},"13710-19-5",{"v":52,"d":"52.00"},{"v":198.7,"d":"198.70"},"<1","N/A","http://selleckchem.com/products/tolfenamic-acid.html","C14H12ClNO2","free base","Clotam","CC1=C(Cl)C=CC=C1NC2=C(C=CC=C2)C(O)=O",{"v":4.16,"d":"4.160"},1,1,3]
["S1960","Pranoprofen","e7","L3900-07","in 10mM DMSO","COX,PGES","Neuronal Signaling","Pranoprofen (Pyranoprofen,Pranopulin) is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.",255.27,"52549-17-4",{"v":51,"d":"51.00"},199.79,"<1","N/A","http://selleckchem.com/products/pranoprofen.html","C15H13NO3","free base","Pyranoprofen,Pranopulin","CC(C(O)=O)C1=CC2=C(OC3=NC=CC=C3C2)C=C1",{"v":3.05,"d":"3.050"},3,0,2]
["S1964","Rimantadine","f7","L3900-07","in 10mM DMSO","Influenza Virus","Microbiology","Rimantadine (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM.",{"v":179.3,"d":"179.30"},"13392-28-4",{"v":33,"d":"33.00"},184.05,{"v":33,"d":"33.00"},184.05,"http://selleckchem.com/products/rimantadine-flumadine.html","C12H21N","free base","N/A","CC(N)[C]12C[CH]3[CH2]C([CH2][CH](C3)C1)C2",2.204,0,1,1]
["S1965","Primidone","g7","L3900-07","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Primidone (NCI-C56360) is an anticonvulsant of the pyrimidinedione class.",218.25,"125-33-7",{"v":44,"d":"44.00"},{"v":201.6,"d":"201.60"},"<1","N/A","http://selleckchem.com/products/Primidone(Mysoline).html","C12H14N2O2","free base","NCI-C56360","CCC1(C(=O)NCNC1=O)C2=CC=CC=C2",0.931,2,2,2]
["S1969","Nefiracetam","h7","L3900-07","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Nefiracetam (DZL 221) is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. Phase 2.",{"v":246.3,"d":"246.30"},"77191-36-7",{"v":49,"d":"49.00"},198.94,{"v":5,"d":"5.00"},{"v":20.3,"d":"20.30"},"http://selleckchem.com/products/Nefiracetam(Translon).html","C14H18N2O2","free base","DZL 221","CC1=CC=CC(=C1NC(=O)CN2CCCC2=O)C",1.443,2,1,3]
["S1971","Nicorandil","a8","L3900-07","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).",211.17,"65141-46-0",{"v":42,"d":"42.00"},198.89,{"v":17,"d":"17.00"},{"v":80.5,"d":"80.50"},"http://selleckchem.com/products/Nicorandil(Ikorel).html","C8H9N3O4","free base","SG-75","[O-][N+](=O)OCCNC(=O)C1=CC=CN=C1",1.758,3,1,5]
["S1972","Tamoxifen (ICI 46474) Citrate","b8","L3900-07","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Endocrinology & Hormones","Tamoxifen Citrate (Istubal,ICI 46474 Citrate) is a selective estrogen receptor modulator (SERM). Tamoxifen Citrate is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis and autophagy.",563.64,"54965-24-1",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://selleckchem.com/products/Tamoxifen-Citrate(Nolvadex).html","C26H29NO.C6H8O7","Citrate","Istubal,ICI 46474 Citrate","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1975","Aripiprazole","c8","L3900-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.",448.39,"129722-12-9",{"v":90,"d":"90.00"},200.72,"<1","N/A","http://selleckchem.com/products/aripiprazole-abilify.html","C23H27Cl2N3O2","free base","OPC-14597","ClC1=CC=CC(=C1Cl)N2CCN(CCCCOC3=CC=C4CCC(=O)NC4=C3)CC2",4.998,2,1,7]
["S1979","Amiodarone (NSC 85442) HCl","d8","L3900-07","in 10mM DMSO","Autophagy,Potassium Channel","Transmembrane Transporters","Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.",681.77,"19774-82-4",{"v":23,"d":"23.00"},33.74,"<1","N/A","http://selleckchem.com/products/amiodarone-hcl.html","C25H29I2NO3.HCl","Hydrochloride","Amiodar,Amiodarone hydrochloride,Nexterone","Cl.CCCCC1=C(C(=O)C2=CC(=C(OCCN(CC)CC)C(=C2)I)I)C3=C(O1)C=CC=C3",{"v":7.62,"d":"7.620"},3,0,11]
["S1983","Adenine HCl","e8","L3900-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Adenine HCl(6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.",171.59,"2922-28-3",{"v":8,"d":"8.00"},46.62,{"v":4,"d":"4.00"},23.31,"http://selleckchem.com/products/adenine-hydrochloride.html","C5H5N5.HCl","Hydrochloride","6-Aminopurine hydrochloride","Cl.NC1=NC=NC2=C1N=C[NH]2",{"v":-0.06,"d":"-0.060"},3,2,0]
["S1987","Mometasone furoate","f8","L3900-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Mometasone Furoate (SCH-32088,mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.",521.43,"83919-23-7",{"v":6,"d":"6.00"},11.51,"<1","N/A","http://selleckchem.com/products/mometasone-furoate.html","C27H30Cl2O6","Furoate","SCH-32088,mometasone 17-furoate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1(OC(=O)C5=CC=CO5)C(=O)CCl",4.616,5,1,5]
["S1988","Propylthiouracil","g8","L3900-07","in 10mM DMSO","Peroxidases","Metabolism","Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.",170.23,"51-52-5",{"v":34,"d":"34.00"},199.73,"<1","N/A","http://selleckchem.com/products/Propylthiouracil.html","C7H10N2OS","free base","NSC 6498, NSC 70461","CCCC1=CC(=O)NC(=S)N1",1.575,1,2,2]
["S1990","Capsaicin(Vanilloid)","h8","L3900-07","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Capsaicin (Qutenza, Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.",305.41,"404-86-4",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://selleckchem.com/products/capsaicin.html","C18H27NO3","free base","Qutenza, Vanilloid","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C\\C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S1992","Fluticasone propionate","a9","L3900-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.",500.57,"80474-14-2",{"v":100,"d":"100.00"},199.77,"<1","N/A","http://selleckchem.com/products/fluticasone-propionate-Flonase-Veramyst.html","C25H31F3O5S","free base","CCI-187881","CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)SCF",4.086,4,1,6]
["S1994","Lacidipine","b9","L3900-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.",455.54,"103890-78-4",{"v":91,"d":"91.00"},199.76,"<1","N/A","http://selleckchem.com/products/lacidipine-lacipil-motens.html","C26H33NO6","free base","GX-1048, GR-43659X, SN-305","CCOC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)\\C=C\\C(=O)OC(C)(C)C)C(=O)OCC)C",3.824,6,1,11]
["S2001","Elvitegravir (JTK-303)","c9","L3900-07","in 10mM DMSO","Integrase","Microbiology","Elvitegravir (GS-9137,JTK-303,D06677) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM in cell-free assays, respectively.",447.88,"697761-98-1",{"v":89,"d":"89.00"},198.71,"<1","N/A","http://selleckchem.com/products/Elvitegravir.html","C23H23ClFNO5","free base","GS-9137,JTK-303,D06677","COC1=CC2=C(C=C1CC3=C(F)C(=CC=C3)Cl)C(=O)C(=CN2C(CO)C(C)C)C(O)=O",4.665,3,1,7]
["S2003","Maraviroc (UK-427857)","d9","L3900-07","in 10mM DMSO","CCR,HIV","Microbiology","Maraviroc (Celsentri,UK-427857) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.",513.67,"376348-65-1",{"v":100,"d":"100.00"},194.68,"<1","N/A","http://selleckchem.com/products/Maraviroc.html","C29H41F2N5O","free base","Celsentri,UK-427857","CC(C)C1=NN=C(C)[N]1C2CC3CCC(C2)N3CCC(NC(=O)C4CCC(F)(F)CC4)C5=CC=CC=C5",3.921,3,1,8]
["S2005","Raltegravir (MK-0518)","e9","L3900-07","in 10mM DMSO","Integrase","Microbiology","Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.",444.42,"518048-05-0",{"v":88,"d":"88.00"},198.01,"<1","N/A","http://selleckchem.com/products/Raltegravir-(MK-0518).html","C20H21FN6O5","free base","MK-0518","CN1C(=O)C(=C(N=C1C(C)(C)NC(=O)C2=NN=C(C)O2)C(=O)NCC3=CC=C(F)C=C3)O",-0.291,7,3,6]
["S2006","Pyrimethamine","f9","L3900-07","in 10mM DMSO","DHFR","Metabolism","Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.",248.71,"58-14-0",{"v":10,"d":"10.00"},40.21,"<1","N/A","http://selleckchem.com/products/Pyrimethamine.html","C12H13ClN4","free base","RP 4753","CCC1=NC(=NC(=C1C2=CC=C(Cl)C=C2)N)N",{"v":2.75,"d":"2.750"},2,2,2]
["S2007","Sulindac","g9","L3900-07","in 10mM DMSO","COX","Neuronal Signaling","Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.",356.41,"38194-50-2",{"v":71,"d":"71.00"},199.21,"<1","N/A","http://selleckchem.com/products/Sulindac(Clinoril).html","C20H17FO3S","free base","MK-231","CC1=C(CC(O)=O)C2=C(C=CC(=C2)F)\\C1=C/C3=CC=C(C=C3)[S](C)=O",3.639,2,0,4]
["S2011","Pramipexole 2HCl Monohydrate","h9","L3900-07","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.",302.26,"191217-81-9",{"v":41,"d":"41.00"},135.64,{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/Pramipexole-dihydrochloride-monohydrate.html","C10H17N3S.2HCl.H2O","Dihydrochloride monohydrate","N/A","O.Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",{"v":1.94,"d":"1.940"},1,2,3]
["S2012","PCI-34051","a10","L3900-07","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.",296.32,"950762-95-5",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/pci-34051.html","C17H16N2O3","free base","N/A","COC1=CC=C(C[N]2C=CC3=C2C=C(C=C3)C(=O)NO)C=C1",2.911,2,1,4]
["S2013","PF-573228","b10","L3900-07","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis.",491.49,"869288-64-2",{"v":26,"d":"26.00"},{"v":52.9,"d":"52.90"},"<1","N/A","http://selleckchem.com/products/pf-573228.html","C22H20F3N5O3S","free base","N/A","C[S](=O)(=O)C1=CC(=CC=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(NC(=O)CC4)C=C3",3.967,5,3,7]
["S2014","BMS-265246","c10","L3900-07","in 10mM DMSO","CDK","Cell Cycle","BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.",345.34,"582315-72-8",{"v":20,"d":"20.00"},57.91,"<1","N/A","http://selleckchem.com/products/bms-265246.html","C18H17F2N3O2","free base","N/A","CCCCOC1=C2C=N[NH]C2=NC=C1C(=O)C3=C(F)C=C(C)C=C3F",4.135,4,1,6]
["S2015","Suplatast Tosylate","d10","L3900-07","in 10mM DMSO","Interleukins","Immunology & Inflammation","Suplatast Tosylate (IPD-1151T, Suplatast Tosilate) is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.",499.64,"94055-76-2",{"v":100,"d":"100.00"},200.14,{"v":100,"d":"100.00"},200.14,"http://selleckchem.com/products/suplatast-tosilate.html","C23H33NO7S2","Tosylate","IPD-1151T, Suplatast Tosilate","CCOCC(O)COC1=CC=C(NC(=O)CC[S+](C)C)C=C1.CC2=CC=C(C=C2)[S]([O-])(=O)=O",0.877,3,2,11]
["S2016","Mirtazapine","e10","L3900-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Mirtazapine (Org3770,6-Azamianserin) is an adrenergic and seroton receptor antagonist, used to treat depression.",265.35,"85650-52-8",{"v":53,"d":"53.00"},199.74,"<1","N/A","http://selleckchem.com/products/mirtazapine-remeron-avanza.html","C17H19N3","free base","Org3770,6-Azamianserin","CN1CCN2C(C1)C3=C(CC4=C2N=CC=C4)C=CC=C3",3.094,1,0,0]
["S2017","Benidipine HCl","f10","L3900-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Benidipine HCl (KW-3049,(±)- Benidipine) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.",542.02,"91599-74-5",{"v":8,"d":"8.00"},14.76,"<1","N/A","http://selleckchem.com/products/benidipine-hydrochloride.html","C28H31N3O6.HCl","Hydrochloride","KW-3049,(±)- Benidipine","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC3CCCN(C3)CC4=CC=CC=C4)C",{"v":4.36,"d":"4.360"},4,1,9]
["S2018","ENMD-2076 L-(+)-Tartaric acid","g10","L3900-07","in 10mM DMSO","Aurora Kinase,FLT3,VEGFR","Angiogenesis","ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.",525.56,"1291074-87-7",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/enmd-2076-l-tartaric-acid.html","C25H31N7O6","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)\\C=C\\C4=CC=CC=C4.OC(C(O)C(O)=O)C(O)=O",-0.683,5,4,8]
["S2020","Formoterol Hemifumarate","h10","L3900-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).",{"v":402.4,"d":"402.40"},"43229-80-7",{"v":80,"d":"80.00"},198.81,"<1","N/A","http://selleckchem.com/products/formoterol-hemifumarate.html","C19H24N2O4.1/2C4H4O4","Hemifumarate","Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate","COC1=CC=C(CC(C)NCC(O)C2=CC=C(O)C(=C2)NC=O)C=C1.COC3=CC=C(CC(C)NCC(O)C4=CC=C(O)C(=C4)NC=O)C=C3.OC(=O)\\C=C\\C(O)=O",-1.526,6,8,18]
["S2024","Ketotifen Fumarate","a11","L3900-07","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ketotifen Fumarate(HC 20511 fumarate) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.",{"v":425.5,"d":"425.50"},"34580-14-8",{"v":8,"d":"8.00"},{"v":18.8,"d":"18.80"},"<1","N/A","http://selleckchem.com/products/ketotifen-fumarate-zaditor.html","C19H19NOS.C4H4O4","Fumarate","HC 20511 fumarate","CN1CCC(CC1)=C2C3=C(CC(=O)C4=C2C=CS4)C=CC=C3.OC(=O)\\C=C\\C(O)=O",0.772,3,0,2]
["S2025","Urapidil HCl","b11","L3900-07","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.",423.94,"64887-14-5",{"v":24,"d":"24.00"},56.61,{"v":85,"d":"85.00"},{"v":200.5,"d":"200.50"},"http://selleckchem.com/products/urapidil-hydrochloride.html","C20H29N5O3.HCl","Hydrochloride","N/A","Cl.COC1=CC=CC=C1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2",1.808,3,1,7]
["S2029","Uridine","c11","L3900-07","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.",{"v":244.2,"d":"244.20"},"58-96-8",{"v":49,"d":"49.00"},200.66,{"v":49,"d":"49.00"},200.66,"http://selleckchem.com/products/uridine.html","C9H12N2O6","free base","NSC 20256,β-Uridine, Uridin","OCC1OC(C(O)C1O)N2C=CC(=O)NC2=O",-2.451,3,4,2]
["S2030","Flunarizine 2HCl","d11","L3900-07","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Flunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.",477.42,"30484-77-6",{"v":5,"d":"5.00"},10.47,"<1","N/A","http://selleckchem.com/products/flunarizine-dihydrochloride.html","C26H26F2N2.2HCl","2HCl","KW-3149, R14950","Cl.Cl.FC1=CC=C(C=C1)C(N2CCN(CC2)C\\C=C\\C3=CC=CC=C3)C4=CC=C(F)C=C4",6.699,0,0,6]
["S2032","Rebamipide","e11","L3900-07","in 10mM DMSO","CCK receptor","GPCR & G Protein","Rebamipide (OPC-12759,Proamipide) is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.",370.79,"90098-04-7",{"v":74,"d":"74.00"},199.57,"<1","N/A","http://selleckchem.com/products/rebamipide.html","C19H15ClN2O4","free base","OPC-12759,Proamipide","OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C3=CC=C(Cl)C=C3",2.606,3,2,5]
["S2036","Aspartame","f11","L3900-07","in 10mM DMSO","Others","Others","Aspartame (SC-18862,Nutrasweet) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages.",{"v":294.3,"d":"294.30"},"22839-47-0",{"v":33,"d":"33.00"},112.13,{"v":4,"d":"4.00"},13.59,"http://selleckchem.com/products/aspartame.html","C14H18N2O5","free base","SC-18862,Nutrasweet","COC(=O)C(CC1=CC=CC=C1)NC(=O)C(N)CC(O)=O",-2.455,4,2,8]
["S2037","Candesartan Cilexetil","g11","L3900-07","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension.",610.66,"145040-37-5",{"v":122,"d":"122.00"},199.78,"<1","N/A","http://selleckchem.com/products/Candesartan-cilexetil-Atacand.html","C33H34N6O6","free base","TCV-116","CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=N[NH]5)C(=CC=C2)C(=O)OC(C)OC(=O)OC6CCCCC6",6.913,10,1,13]
["S2038","Phentolamine Mesylate","h11","L3900-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Phentolamine Mesylate(Phentolamine methanesulfonate) is a reversible and nonselective alpha-adrenergic receptor antagonist, used for the prevention or control of hypertensive episodes.",377.46,"65-28-1",{"v":76,"d":"76.00"},201.35,{"v":76,"d":"76.00"},201.35,"http://selleckchem.com/products/phentolamine-mesilate.html","C17H19N3O.CH4O3S","Mesylate","Phentolamine methanesulfonate","CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.C[S](O)(=O)=O",2.555,1,2,4]
["S2040","Nimesulide","a2","L3900-08","in 10mM DMSO","COX","Neuronal Signaling","Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.",308.31,"51803-78-2",{"v":62,"d":"62.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://selleckchem.com/products/Nimesulide.html","C13H12N2O5S","free base","N/A","C[S](=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O",2.195,3,1,5]
["S2041","Dyclonine HCl","b2","L3900-08","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Dyclonine HCl(Dyclocaine HCl) is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.",325.87,"536-43-6",{"v":15,"d":"15.00"},46.03,{"v":6,"d":"6.00"},18.41,"http://selleckchem.com/products/dyclonine-hydrochloride.html","C18H27NO2.HCl","Hydrochloride","Dyclocaine HCl","Cl.CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2",4.435,2,0,8]
["S2042","Cyproterone Acetate","c2","L3900-08","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.",416.94,"427-51-0",{"v":83,"d":"83.00"},199.07,"<1","N/A","http://selleckchem.com/products/cyproterone-acetate.html","C24H29ClO4","free base","N/A","CC(=O)OC1(CCC2C3C=C(Cl)C4=CC(=O)C5CC5C4(C)C3CCC12C)C(C)=O",3.314,4,0,3]
["S2043","Memantine HCl","d2","L3900-08","in 10mM DMSO","NMDAR","Neuronal Signaling","Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.",215.76,"41100-52-1",{"v":43,"d":"43.00"},{"v":199.3,"d":"199.30"},{"v":30,"d":"30.00"},139.04,"http://selleckchem.com/products/memantine-hydrochloride-namenda.html","C12H21N.HCl","Hydrochloride","N/A","Cl.CC12C[CH]3CC(C)([CH2]1)C[C](N)(C3)C2",2.289,0,1,0]
["S2044","Cyproheptadine HCl","e2","L3900-08","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Cyproheptadine HCl(Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.",323.86,"969-33-5",{"v":65,"d":"65.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/cyproheptadine-hydrochloride-periactin.html","C21H21N.HCl","Hydrochloride","Periactin","Cl.CN1CCC(CC1)=C2C3=C(C=CC=C3)C=CC4=C2C=CC=C4",4.744,0,0,0]
["S2045","Doxifluridine","f2","L3900-08","in 10mM DMSO","Phosphorylase","Metabolism","Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).",246.19,"3094-09-5",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/doxifluridine.html","C9H11FN2O5","free base","5'-DFUR, AMC 0101","CC1OC(C(O)C1O)N2C=C(F)C(=O)NC2=O",-1.653,3,3,1]
["S2046","Pioglitazone HCl","g2","L3900-08","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17),PPAR","Metabolism","Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.",{"v":392.9,"d":"392.90"},"112529-15-4",{"v":79,"d":"79.00"},201.07,"<1","N/A","http://selleckchem.com/products/pioglitazone-hydrochloride-actos.html","C19H20N2O3S.HCl","Hydrochloride","AD-4833, U-72107E","Cl.CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",4.289,4,1,7]
["S2051","Captopril","h2","L3900-08","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.",217.29,"62571-86-2",{"v":43,"d":"43.00"},197.89,{"v":2,"d":"2.00"},{"v":9.2,"d":"9.20"},"http://selleckchem.com/products/captopril-capoten.html","C9H15NO3S","free base","SQ 14225,Capoten","CC(CS)C(=O)N1CCCC1C(O)=O",0.667,2,0,3]
["S2052","Oxytetracycline Dihydrate","a3","L3900-08","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.",496.46,"6153-64-6",{"v":5,"d":"5.00"},10.07,"<1","N/A","http://selleckchem.com/products/oxytetracycline-dihydrate.html","C22H24N2O9.2H2O","Dihydrate","N/A","O.O.CN(C)C1C2C(O)C3C(=C(O)C2(O)C(=O)C(=C1O)C(N)=O)C(=O)C4=C(O)C=CC=C4C3(C)O",-2.309,3,5,2]
["S2054","Orphenadrine Citrate","b3","L3900-08","in 10mM DMSO","AChR","Neuronal Signaling","Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.",{"v":461.5,"d":"461.50"},"4682-36-4",{"v":92,"d":"92.00"},199.35,"<1","N/A","http://selleckchem.com/products/orphenadrine-citrate-norflex.html","C18H23NO.C6H8O7","Citrate","N/A","CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2C.OC(=O)CC(O)(CC(O)=O)C(O)=O",-0.483,4,0,11]
["S2055","Gimeracil","c3","L3900-08","in 10mM DMSO","Dehydrogenase","Metabolism","Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.",145.54,"103766-25-2",{"v":29,"d":"29.00"},199.26,"<1","N/A","http://selleckchem.com/products/gimeracil.html","C5H4ClNO2","free base","N/A","OC1=CC(=O)NC=C1Cl",-0.493,1,2,0]
["S2057","Cyclophosphamide (NSC-26271) Monohydrate","d3","L3900-08","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.",{"v":279.1,"d":"279.10"},"6055-19-2",{"v":55,"d":"55.00"},197.06,{"v":7,"d":"7.00"},25.08,"http://selleckchem.com/products/cyclophosphamide-monohydrate.html","C7H15Cl2N2O2P.H2O","Monohydrate","Cytoxan Monohydrate","O.ClCCN(CCCl)[P]1(=O)NCCCO1",-0.063,2,1,5]
["S2059","Terazosin HCl Dihydrate","e3","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Terazosin HCl is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).",459.92,"70024-40-7",{"v":26,"d":"26.00"},56.53,"<1","N/A","http://selleckchem.com/products/terazosin-hydrochloride-hytrin.html","C19H25N5O4.HCl.2H2O","HCl & Dihydrate","N/A","O.O.Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N",1.348,6,1,4]
["S2060","Bromhexine HCl","f3","L3900-08","in 10mM DMSO","Others","Others","Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.",412.59,"611-75-6",{"v":6,"d":"6.00"},14.54,"<1","N/A","http://selleckchem.com/products/bromhexine-hydrochloride.html","C14H20Br2N2.HCl","HCl","N/A","Cl.CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2",4.894,0,1,3]
["S2061","Lovastatin (MK-803)","g3","L3900-08","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Lovastatin (MK-803, Mevinolin,Mevacor) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.",404.54,"75330-75-5",{"v":8,"d":"8.00"},19.78,"<1","N/A","http://selleckchem.com/products/lovastatin-mevacor.html","C24H36O5","free base","Mevinolin,Mevacor","CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.218,4,1,7]
["S2062","Tiopronin","h3","L3900-08","in 10mM DMSO","ROS","Immunology & Inflammation","Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.",163.19,"1953-02-2",{"v":32,"d":"32.00"},196.09,{"v":32,"d":"32.00"},196.09,"http://selleckchem.com/products/tiopronin-thiola.html","C5H9NO3S","free base","N/A","CC(S)C(=O)NCC(O)=O",-0.362,2,1,3]
["S2064","Balofloxacin","a4","L3900-08","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Balofloxacin (Q-35,Q-roxin) is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.",389.42,"127294-70-6",{"v":5,"d":"5.00"},12.84,"<1","N/A","http://selleckchem.com/products/balofloxacin.html","C20H24FN3O4","free base","Q-35,Q-roxin","CNC1CCCN(C1)C2=C(OC)C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O",-0.615,3,1,5]
["S2065","Lafutidine","b4","L3900-08","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lafutidine (FRG-8813), a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.",431.55,"118288-08-7",{"v":86,"d":"86.00"},199.28,"<1","N/A","http://selleckchem.com/products/lafutidine.html","C22H29N3O4S","free base","FRG-8813","O=C(C[S](=O)CC1=CC=CO1)NC\\C=C/COC2=CC(=CC=N2)CN3CCCCC3",1.987,5,1,11]
["S2066","Moxonidine","c4","L3900-08","in 10mM DMSO","Imidazoline Receptor","GPCR & G Protein","Moxonidine (BDF5895) is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.",241.68,"75438-57-2",{"v":24,"d":"24.00"},{"v":99.3,"d":"99.30"},"<1","N/A","http://selleckchem.com/products/moxonidine.html","C9H12ClN5O","free base","BDF5895","COC1=NC(=NC(=C1NC2=NCCN2)Cl)C",0.598,4,2,3]
["S2067","Ozagrel HCl","d4","L3900-08","in 10mM DMSO","P450 (e.g. CYP17),Prostaglandin Receptor","Metabolism","Ozagrel HCl (OKY-046) is a selective <n>thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.",264.71,"78712-43-3",{"v":52,"d":"52.00"},196.44,{"v":52,"d":"52.00"},196.44,"http://selleckchem.com/products/ozagrel-hydrochloride.html","C13H12N2O2.HCl","HCl","OKY-046 HCl","Cl.OC(=O)/C=C/C1=CC=C(C[N]2C=CN=C2)C=C1",1.986,2,0,4]
["S2069","Argatroban (MCI-9038)","e4","L3900-08","in 10mM DMSO","Thrombin","Proteases","Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.",508.63,"74863-84-6",{"v":9,"d":"9.00"},17.69,"<1","N/A","http://selleckchem.com/products/argatroban.html","C23H36N6O5S","free base","MCI-9038","CC1CCN(C(C1)C(O)=O)C(=O)C(CCCNC(N)=N)N[S](=O)(=O)C2=CC=CC3=C2NCC(C)C3",1.266,4,4,10]
["S2071","Prulifloxacin (NM441)","f4","L3900-08","in 10mM DMSO","COVID-19","Microbiology","Prulifloxacin (NM441, AF 3013), the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent.",461.46,"123447-62-1",{"v":11,"d":"11.00"},23.84,"<1","N/A","http://www.selleckchem.com/products/prulifloxacin-pruvel.html","C21H20FN3O6S","Free Base","AF 3013","CC1SC2=C(C(O)=O)C(=O)C3=CC(=C(C=C3N12)N4CCN(CC4)CC5=C(C)OC(=O)O5)F",0.031,5,0,4]
["S2072","Seratrodast(AA-2414)","g4","L3900-08","in 10mM DMSO","Prostaglandin Receptor","Metabolism","Seratrodast (AA-2414, ABT-001) is a potent and selective thromboxane A2 receptor (TP) antagonist which is used primarily in the treatment of asthma and used as anti-inflammatory agent.",354.44,"112665-43-7",{"v":71,"d":"71.00"},200.32,"<1","N/A","http://www.selleck.cn/products/seratrodast.html","C22H26O4","Free Base","ABT-001","CC1=C(C)C(=O)C(=C(C)C1=O)C(CCCCCC(O)=O)C2=CC=CC=C2",5.216,3,0,8]
["S2075","Rosiglitazone (BRL-49653) HCl","h4","L3900-08","in 10mM DMSO","PPAR","Metabolism","Rosiglitazone HCl (BRL-49653) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.",393.89,"302543-62-0",{"v":79,"d":"79.00"},200.56,"<1","N/A","http://selleckchem.com/products/rosiglitazone-hydrochloride.html","C18H19N3O3S.HCl","HCl","BRL-49653 HCl","Cl.CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",{"v":3.65,"d":"3.650"},4,1,7]
["S2077","Atorvastatin Calcium","a5","L3900-08","in 10mM DMSO","Apoptosis related,Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.",1155.34,"134523-03-8",{"v":100,"d":"100.00"},86.55,"<1","N/A","http://selleckchem.com/products/atorvastatin-calcium-lipitor.html","2(C33H34FN2O5).Ca","Calcium","N/A","[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8",8.163,2,6,24]
["S2078","Famotidine","b5","L3900-08","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.",337.45,"76824-35-6",{"v":67,"d":"67.00"},198.55,"<1","N/A","http://selleckchem.com/products/famotidine-pepcid.html","C8H15N7O2S3","free base","MK208","NC(=N)NC1=NC(=CS1)CSCCC(=N)N[S](N)(=O)=O",-1.328,3,4,9]
["S2079","Moexipril HCl","c5","L3900-08","in 10mM DMSO","ACE,COVID-19,RAAS","Endocrinology & Hormones","Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.",535.03,"82586-52-5",{"v":20,"d":"20.00"},37.38,"<1","N/A","http://selleckchem.com/products/moexipril-hydrochloride.html","C27H34N2O7.HCl","Hydrochloride","RS-10085","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC(=C(OC)C=C3CC2C(O)=O)OC",1.005,6,1,12]
["S2080","Clevidipine Butyrate","d5","L3900-08","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Clevidipine Butyrate(Cleviprex) is a dihydropyridine calcium channel blocker,  uses as an agent for the reduction of blood pressure.",456.32,"167221-71-8",{"v":91,"d":"91.00"},199.42,"<1","N/A","http://selleckchem.com/products/cleviprex-clevidipine.html","C21H23Cl2NO6","free base","Cleviprex","CCCC(=O)OCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",4.145,6,1,10]
["S2083","Procaterol HCl","e5","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Procaterol HCl (OPC-2009) is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma",326.82,"62929-91-3",{"v":65,"d":"65.00"},198.89,{"v":65,"d":"65.00"},198.89,"http://www.selleckchem.com/products/procaterol-hcl.html","C16H22N2O3.HCl","hydrochloride","OPC-2009","Cl.CCC(NC(C)C)C(O)C1=CC=C(O)C2=C1C=CC(=O)N2",2.781,1,4,5]
["S2084","Duloxetine HCl","f5","L3900-08","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Duloxetine HCl (LY-248686) is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).",333.88,"136434-34-9",{"v":67,"d":"67.00"},200.67,"<1","N/A","http://selleckchem.com/products/duloxetine-hcl-cymbalta.html","C18H19NOS.HCl","HCl","LY-248686 HCl","Cl.CNCCC(OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3",4.228,1,1,6]
["S2085","Trimebutine","g5","L3900-08","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Trimebutine (Mebutin) is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.",387.47,"39133-31-8",{"v":50,"d":"50.00"},129.04,"<1","N/A","http://selleckchem.com/products/trimebutine.html","C22H29NO5","free base","Mebutin","CCC(COC(=O)C1=CC(=C(OC)C(=C1)OC)OC)(N(C)C)C2=CC=CC=C2",4.115,5,0,10]
["S2086","Ivabradine HCl","h5","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.",505.05,"148849-67-6",{"v":101,"d":"101.00"},199.98,{"v":82,"d":"82.00"},162.36,"http://selleckchem.com/products/ivabradine-hcl-procoralan.html","C27H36N2O5.HCl","HCl","S 16257-2,S-18982 D6 hydrochloride","Cl.COC1=CC2=C(CC(=O)N(CCCN(C)CC3CC4=CC(=C(OC)C=C34)OC)CC2)C=C1OC",3.753,5,0,10]
["S2087","Rivastigmine Tartrate","a6","L3900-08","in 10mM DMSO","AChR","Neuronal Signaling","Rivastigmine Tartrate (ENA 713) is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.",400.42,"129101-54-8",{"v":42,"d":"42.00"},104.89,{"v":80,"d":"80.00"},199.79,"http://selleckchem.com/products/rivastigmine-tartrate-exelon.html","C14H22N2O2.C4H6O6","Tartrate","ENA 713","CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.OC(C(O)C(O)=O)C(O)=O",-2.099,4,2,8]
["S2090","Dexmedetomidine HCl","b6","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.",236.74,"145108-58-3",{"v":48,"d":"48.00"},202.75,"<1","N/A","http://selleckchem.com/products/dexmedetomidine-hcl-precedex.html","C13H16N2.HCl","HCl","(+)-Medetomidine Hydrochloride","Cl.CC(C1=CN=C[NH]1)C2=CC=CC(=C2C)C",3.378,1,1,2]
["S2091","Betaxolol","c6","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Betaxolol (SL 75212,Dextrobetaxolol) is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.",307.43,"63659-18-7",{"v":62,"d":"62.00"},201.67,{"v":62,"d":"62.00"},201.67,"http://selleckchem.com/products/betaxolol-betoptic.html","C18H29NO3","free base","SL 75212,Dextrobetaxolol","CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1",2.577,2,2,11]
["S2096","Almotriptan Malate","d6","L3900-08","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Almotriptan Malate (LAS 31416) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.",469.55,"181183-52-8",{"v":94,"d":"94.00"},200.19,"<1","N/A","http://selleckchem.com/products/almotriptan-malate-axert.html","C17H25N3O2S.C4H6O5","Malate","LAS 31416","CN(C)CCC1=C[NH]C2=CC=C(C[S](=O)(=O)N3CCCC3)C=C12.OC(CC(O)=O)C(O)=O",-1.943,4,2,9]
["S2097","Ambrisentan","e6","L3900-08","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Ambrisentan (LU-208075, BSF-208075) is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).",378.42,"177036-94-1",{"v":76,"d":"76.00"},200.84,"<1","N/A","http://selleckchem.com/products/ambrisentan.html","C22H22N2O4","free base","LU-208075, BSF-208075","COC(C(OC1=NC(=CC(=N1)C)C)C(O)=O)(C2=CC=CC=C2)C3=CC=CC=C3",3.659,5,0,7]
["S2098","Bexarotene (LGD1069)","f6","L3900-08","in 10mM DMSO","Retinoid Receptor","Metabolism","Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.",{"v":348,"d":"348.00"},"153559-49-0",{"v":8,"d":"8.00"},22.99,"<1","N/A","http://selleckchem.com/products/bexarotene.html","C24H28O2","free base","Targretin","CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(O)=O)C(C)(C)CCC2(C)C",6.405,1,0,3]
["S2099","Temocapril HCl","g6","L3900-08","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.",513.07,"110221-44-8",{"v":103,"d":"103.00"},200.75,"<1","N/A","http://selleckchem.com/products/temocapril-hcl.html","C23H28N2O5S2.HCl","Hydrochloride","CS-622 HCl","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(CC(O)=O)C2=O)C3=CC=CS3",0.787,4,1,11]
["S2101","Gabexate Mesylate","h6","L3900-08","in 10mM DMSO","Serine Protease","Proteases","Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.",417.48,"56974-61-9",{"v":83,"d":"83.00"},198.81,{"v":12,"d":"12.00"},28.74,"http://selleckchem.com/products/gabexate-mesylate.html","C16H23N3O4.CH4O3S","Mesylate","FOY","CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1.C[S](O)(=O)=O",1.774,4,2,12]
["S2102","Rasagiline Mesylate","a7","L3900-08","in 10mM DMSO","MAO","Metabolism","Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.",267.34,"161735-79-1",{"v":53,"d":"53.00"},198.25,{"v":53,"d":"53.00"},198.25,"http://selleckchem.com/products/rasagiline-mesylate.html","C12H13N.CH4O3S","Mesylate","TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate","C[S](O)(=O)=O.C#CCNC1CCC2=CC=CC=C12",2.705,0,1,2]
["S2103","Naltrexone HCl","b7","L3900-08","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Naltrexone HCl(PTI-901) is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.",377.86,"16676-29-2",{"v":14,"d":"14.00"},37.05,{"v":14,"d":"14.00"},37.05,"http://selleckchem.com/products/naltrexone-hcl.html","C20H23NO4.HCl","Hydrochloride","PTI-901","Cl.OC1=CC=C2CC3N(CCC45C(OC1=C24)C(=O)CCC35O)CC6CC6",2.039,2,1,2]
["S2104","Levosulpiride","c7","L3900-08","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Levosulpiride(RV-12309,S-(-)-Sulpiride) is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.",341.43,"23672-07-3",{"v":69,"d":"69.00"},202.09,"<1","N/A","http://selleckchem.com/products/levosulpiride-levogastrol.html","C15H23N3O4S","free base","RV-12309,S-(-)-Sulpiride","CCN1CCCC1CNC(=O)C2=C(OC)C=CC(=C2)[S](N)(=O)=O",0.704,4,2,6]
["S2105","Pantoprazole","d7","L3900-08","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",383.37,"102625-70-7",{"v":76,"d":"76.00"},198.24,"<1","N/A","http://selleckchem.com/products/pantoprazole-protonix.html","C16H15F2N3O4S","free base","SKFSKF96022, BY-1023","COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=CC=C(OC(F)F)C=C3[NH]2",2.737,6,1,7]
["S2109","Imidapril HCl","e7","L3900-08","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.",441.91,"89396-94-1",{"v":88,"d":"88.00"},199.14,{"v":54,"d":"54.00"},{"v":122.2,"d":"122.20"},"http://selleckchem.com/products/imidapril-tanatril.html","C20H27N3O6.HCl","Hydrochloride","TA-6366","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C)C2=O)C(O)=O",-1.197,5,1,10]
["S2111","Lapatinib (GW-572016)","f7","L3900-08","in 10mM DMSO","Autophagy,EGFR,Ferroptosis,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.",581.06,"231277-92-2",{"v":100,"d":"100.00"},{"v":172.1,"d":"172.10"},"<1","N/A","http://selleckchem.com/products/lapatinib.html","C29H26ClFN4O4S","free base","GSK572016, GW2016","C[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(=C5)F)C(=C4)Cl)C3=C2",6.041,6,2,11]
["S2113","Cisatracurium Besylate","g7","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Cisatracurium Besylate(51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.",1243.48,"96946-42-8",{"v":249,"d":"249.00"},200.24,{"v":47,"d":"47.00"},{"v":37.8,"d":"37.80"},"http://selleckchem.com/products/cisatracurium-besylate-nimbex.html","C53H72N2O12.2C6H5O3S","Besylate","51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S2114","Dronedarone HCl","h7","L3900-08","in 10mM DMSO","Calcium Channel,Potassium Channel,Sodium Channel","Transmembrane Transporters","Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).",593.22,"141625-93-6",{"v":80,"d":"80.00"},134.86,"<1","N/A","http://selleckchem.com/products/dronedarone-hcl-multaq.html","C31H44N2O5S.HCl","HCl","SR33589","Cl.CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=CC=C(N[S](C)(=O)=O)C=C23",7.397,5,1,18]
["S2116","Conivaptan HCl","a8","L3900-08","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Conivaptan HCl(YM 087) is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia.",535.04,"168626-94-6",{"v":107,"d":"107.00"},199.99,"<1","N/A","http://selleckchem.com/products/conivaptan-hcl-vaprisol.html","C32H26N4O2.HCl","HCl","YM 087","Cl.CC1=NC2=C([NH]1)C3=C(C=CC=C3)N(CC2)C(=O)C4=CC=C(NC(=O)C5=C(C=CC=C5)C6=CC=CC=C6)C=C4",{"v":5.68,"d":"5.680"},3,2,4]
["S2118","Ibutilide Fumarate","b8","L3900-08","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ibutilide Fumarate (U-70226E,Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.",885.23,"122647-32-9",{"v":89,"d":"89.00"},100.54,{"v":89,"d":"89.00"},100.54,"http://selleckchem.com/products/ibutilide-fumarate.html","(C20H36N2O3S)2.C4H4O4","Fumarate","U-70226E,Corvert Fumarate","CCCCCCCN(CC)CCCC(O)C1=CC=C(N[S](C)(=O)=O)C=C1.CCCCCCCN(CC)CCCC(O)C2=CC=C(N[S](C)(=O)=O)C=C2.OC(=O)\\C=C\\C(O)=O",1.954,6,4,30]
["S2119","Probucol","c8","L3900-08","in 10mM DMSO","LDL","Metabolism","Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.",516.84,"23288-49-5",{"v":103,"d":"103.00"},199.29,"<1","N/A","http://selleckchem.com/products/probucol.html","C31H48O2S2","free base","DH-581","CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(O)C(=C2)C(C)(C)C)C(C)(C)C",9.779,0,2,8]
["S2123","Dextrose","d8","L3900-08","in 10mM DMSO","Others","Others","Dextrose (D-glucose), a simple sugar (monosaccharide), is an important carbohydrate in biology.",180.16,"50-99-7",{"v":36,"d":"36.00"},199.82,{"v":36,"d":"36.00"},199.82,"http://selleckchem.com/products/Dextrose(D-glucose).html","C6H12O6","free base","D-glucose","OCC(O)C(O)C(O)C(O)C=O",-2.791,1,5,5]
["S2126","Naftopidil","e8","L3900-08","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Naftopidil (KT-611) is a selective α1-adrenergic receptor antagonist with Ki of 3.7 nM, 20 nM, and 1.2 nM for α1a, α1b, and α1d, respectively, used for the treatment of benign prostatic hyperplasia.",392.49,"57149-07-2",{"v":79,"d":"79.00"},201.28,"<1","N/A","http://selleckchem.com/products/Naftopidil(Flivas).html","C24H28N2O3","Free Base","KT-611","COC1=CC=CC=C1N2CCN(CC2)CC(O)COC3=C4C=CC=CC4=CC=C3",3.962,2,1,7]
["S2127","S-(+)-Rolipram","f8","L3900-08","in 10mM DMSO","PDE","Metabolism","S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.",275.34,"85416-73-5",{"v":55,"d":"55.00"},199.75,"<1","N/A","http://selleckchem.com/products/sRolipram.html","C16H21NO3","free base","N/A","COC1=C(OC2CCCC2)C=C(C=C1)C3CNC(=O)C3",2.349,3,1,4]
["S2128","Bazedoxifene (WAY-140424) HCl","g8","L3900-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bazedoxifene HCl (WAY-140424, TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of  23 nM and 89 nM, respectively.",507.06,"198480-56-7",{"v":101,"d":"101.00"},199.19,"<1","N/A","http://selleckchem.com/products/bazedoxifene-hcl.html","C30H34N2O3.HCl","Hydrochloride","TSE-424","Cl.CC1=C([N](CC2=CC=C(OCCN3CCCCCC3)C=C2)C4=CC=C(O)C=C14)C5=CC=C(O)C=C5",7.602,1,2,7]
["S2130","Atropine sulfate monohydrate","h8","L3900-08","in 10mM DMSO","AChR,ADC Cytotoxin","Neuronal Signaling","Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.",694.83,"5908-99-6",{"v":139,"d":"139.00"},200.05,{"v":139,"d":"139.00"},200.05,"http://selleckchem.com/products/Atropine-sulfate-monohydrate.html","2(C17H23NO3).H2O.H2SO4","Sulfate monohydrate","N/A","O.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.628,4,2,10]
["S2131","Roflumilast (B9302-107)","a9","L3900-08","in 10mM DMSO","PDE","Metabolism","Roflumilast (APTA 2217, B9302-107, BY 217, BYK 20869) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.",403.21,"162401-32-3",{"v":81,"d":"81.00"},200.89,"<1","N/A","http://selleckchem.com/products/Roflumilast(Daxas).html","C17H14Cl2F2N2O3","free base","APTA 2217, B9302-107, BY 217, BYK 20869","FC(F)OC1=CC=C(C=C1OCC2CC2)C(=O)NC3=C(Cl)C=NC=C3Cl",4.402,4,1,7]
["S2134","AZD8330","b9","L3900-08","in 10mM DMSO","MEK","MAPK","AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.",461.23,"869357-68-6",{"v":92,"d":"92.00"},199.47,"<1","N/A","http://selleckchem.com/products/AZD8330(ARRY-424704).html","C16H17FIN3O4","free base","ARRY704","CN1C(=O)C(=CC(=C1NC2=C(F)C=C(I)C=C2)C(=O)NOCCO)C",1.653,3,3,6]
["S2149","GSK1292263","c9","L3900-08","in 10mM DMSO","GPR","Endocrinology & Hormones","GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. Phase 2.",456.56,"1032823-75-8",{"v":34,"d":"34.00"},74.47,"<1","N/A","http://selleckchem.com/products/GSK1292263.html","C23H28N4O4S","free base","N/A","CC(C)C1=NOC(=N1)N2CCC(CC2)COC3=CN=C(C=C3)C4=CC=C(C=C4)[S](C)(=O)=O",3.893,7,0,7]
["S2151","Sonidegib (NVP-LDE225)","d9","L3900-08","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.",{"v":485.5,"d":"485.50"},"956697-53-3",{"v":97,"d":"97.00"},199.79,"<1","N/A","http://selleckchem.com/products/LDE225(NVP-LDE225).html","C26H26F3N3O3","free base","Erismodegib","CC1CN(CC(C)O1)C2=CC=C(NC(=O)C3=C(C)C(=CC=C3)C4=CC=C(OC(F)(F)F)C=C4)C=N2",6.732,4,1,6]
["S2153","CGS 21680 HCl","e9","L3900-08","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor.",535.98,"124431-80-7",{"v":100,"d":"100.00"},186.57,"<1","N/A","http://selleckchem.com/products/CGS-21680-hydrochloride.html","C23H29N7O6.HCl","Hydrochloride","N/A","Cl.CCNC(=O)C1OC(C(O)C1O)[N]2C=NC3=C2N=C(NCCC4=CC=C(CCC(O)=O)C=C4)N=C3N",0.911,6,5,10]
["S2154","Dabigatran (BIBR-1048) etexilate","f9","L3900-08","in 10mM DMSO","Thrombin","Proteases","Dabigatran Etexilate (BIBR-1048) is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.",627.73,"211915-06-9",{"v":126,"d":"126.00"},200.72,"<1","N/A","http://selleckchem.com/products/BIBR-1048(Dabigatran-etexilate).html","C34H41N7O5","free base","BIBR-1048","CCCCCCOC(=O)N=C(N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)[N]2C)C=C1",5.751,8,2,17]
["S2155","LY2608204","g9","L3900-08","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.",559.81,"1234703-40-2",{"v":112,"d":"112.00"},200.07,"<1","N/A","http://selleckchem.com/products/ly2608204.html","C28H37N3O3S3","free base","N/A","O=C(NC1=NC=C(SCCN2CCCC2)S1)C3(CC3C4CCCCC4)C5=CC=C(C=C5)[S](=O)(=O)C6CC6",5.393,4,1,10]
["S2156","LY2886721","h9","L3900-08","in 10mM DMSO","BACE","Neuronal Signaling","LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.",390.41,"1262036-50-9",{"v":9,"d":"9.00"},23.05,"<1","N/A","http://selleckchem.com/products/LY-2886721.html","C18H16F2N4O2S","free base","N/A","NC1=NC2(COCC2CS1)C3=CC(=CC=C3F)NC(=O)C4=NC=C(F)C=C4",2.134,4,2,3]
["S2158","KW-2449","a10","L3900-08","in 10mM DMSO","Aurora Kinase,Bcr-Abl,FLT3","Angiogenesis","KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.",{"v":332.4,"d":"332.40"},"1000669-72-6",{"v":67,"d":"67.00"},201.56,"<1","N/A","http://selleckchem.com/products/KW-2449.html","C20H20N4O","free base","N/A","O=C(N1CCNCC1)C2=CC=C(C=C2)/C=C/C3=N[NH]C4=C3C=CC=C4",2.723,2,2,3]
["S2159","Tebipenem Pivoxil","b10","L3900-08","in 10mM DMSO","Antibiotics","Microbiology","Tebipenem pivoxil (L-084, ME1211,TBPM-PI,LJC 11036) is an oral carbapenem antibiotic, use to treat otolaryngologic and respiratory infections.",497.63,"161715-24-8",{"v":99,"d":"99.00"},198.94,"<1","N/A","http://selleckchem.com/products/Tebipenem-pivoxil(L-084).html","C22H31N3O6S2","free base","L-084, ME1211,TBPM-PI,LJC 11036","CC(O)C1C2C(C)C(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)SC3CN(C3)C4=NCCS4",1.782,6,1,10]
["S2160","Almorexant HCl","c10","L3900-08","in 10mM DMSO","OX Receptor","GPCR & G Protein","Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.",549.02,"913358-93-7",{"v":72,"d":"72.00"},131.14,"<1","N/A","http://selleckchem.com/products/almorexant-hcl.html","C29H32ClF3N2O3","Hydrochloride","ACT-078573 HCl","Cl.CNC(=O)C(N1CCC2=C(C=C(OC)C(=C2)OC)C1CCC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C4",6.438,3,1,9]
["S2161","RAF265 (CHIR-265)","d10","L3900-08","in 10mM DMSO","Apoptosis related,Raf,VEGFR","MAPK","RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.",518.41,"927880-90-8",{"v":100,"d":"100.00"},{"v":192.9,"d":"192.90"},"<1","N/A","http://selleckchem.com/products/RAF265(CHIR-265).html","C24H16F6N6O","free base","N/A","C[N]1C(=NC2=C1C=CC(=C2)OC3=CC=NC(=C3)C4=NC=C([NH]4)C(F)(F)F)NC5=CC=C(C=C5)C(F)(F)F",6.469,4,2,7]
["S2162","AZD1480","e10","L3900-08","in 10mM DMSO","JAK","JAK/STAT","AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.",348.77,"935666-88-9",{"v":70,"d":"70.00"},200.71,"<1","N/A","http://www.selleck.cn/products/AZD1480.html","C14H14ClFN8","free base","N/A","CC(NC1=NC=C(Cl)C(=N1)NC2=N[NH]C(=C2)C)C3=NC=C(F)C=N3",2.645,5,3,5]
["S2167","Bazedoxifene (TSE-424) acetate","f10","L3900-08","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Bazedoxifene Acetate (WAY-140424,TSE-424 acetate) is a third generation selective estrogen receptor modulator (SERM).",530.65,"198481-33-3",{"v":100,"d":"100.00"},188.45,"<1","N/A","http://selleckchem.com/products/Bazedoxifene-acetate.html","C30H34N2O3.C2H4O2","Acetate","WAY-140424,TSE-424 acetate","CC(O)=O.CC1=C([N](CC2=CC=C(OCCN3CCCCCC3)C=C2)C4=CC=C(O)C=C14)C5=CC=C(O)C=C5",3.981,2,2,7]
["S2169","Rosuvastatin (ZD4522) calcium","g10","L3900-08","in 10mM DMSO","COVID-19,HMG-CoA Reductase","Metabolism","Rosuvastatin Calcium (ZD4522 calcium) is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.",500.57,"147098-20-2",{"v":100,"d":"100.00"},199.77,"<1","N/A","http://selleckchem.com/products/Rosuvastatin-calcium(Crestor).html","C22H28FN3O6S.1/2Ca","Calcium salt","ZD4522 calcium","[Ca++].CC(C)C1=C(\\C=C\\C(O)CC(O)CC([O-])=O)C(=NC(=N1)N(C)[S](C)(=O)=O)C2=CC=C(F)C=C2.CC(C)C3=C(\\C=C\\C(O)CC(O)CC([O-])=O)C(=NC(=N3)N(C)[S](C)(=O)=O)C4=CC=C(F)C=C4",1.906,8,4,20]
["S2170","Givinostat (ITF2357)","h10","L3900-08","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.",475.97,"732302-99-7",{"v":95,"d":"95.00"},199.59,"<1","N/A","http://selleckchem.com/products/ITF2357(Givinostat).html","C24H27N3O4.HCl.H2O","Chloride","N/A","O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC3=CC=C(C=C3)C(=O)NO)C=C2",4.046,3,2,9]
["S2173","Telotristat Etiprate (LX 1606 Hippurate)","a11","L3900-08","in 10mM DMSO","Hydroxylase","Metabolism","Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.",754.15,"1137608-69-5",{"v":100,"d":"100.00"},{"v":132.6,"d":"132.60"},"<1","N/A","http://selleckchem.com/products/telotristat-etiprate-lx-1606-hippurate.html","C27H26ClF3N6O3.C9H9NO3","Hippuric acid","N/A","CCOC(=O)C(N)CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=CC=C(Cl)C=C3[N]4C=CC(=N4)C)C(F)(F)F.OC(=O)CNC(=O)C5=CC=CC=C5",3.747,8,3,14]
["S2177","Dichlorphenamide","b11","L3900-08","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Dichlorphenamide (Diclofenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.",305.16,"120-97-8",{"v":61,"d":"61.00"},199.89,"N/A","N/A","http://www.selleckchem.com/products/Dichlorphenamide(Diclofenamide).html","C6H6Cl2N2O4S2","Free Base","Diclofenamide","N[S](=O)(=O)C1=CC(=C(Cl)C(=C1)[S](N)(=O)=O)Cl","N/A","N/A","N/A","N/A"]
["S2178","AG-14361","c11","L3900-08","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.",320.39,"328543-09-5",{"v":12,"d":"12.00"},37.45,"<1","N/A","http://selleckchem.com/products/AG14361.html","C19H20N4O","free base","N/A","CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3[N]2CCNC4=O",2.576,2,1,3]
["S2179","Gandotinib (LY2784544)","d11","L3900-08","in 10mM DMSO","JAK","JAK/STAT","Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.",469.94,"1229236-86-5",{"v":94,"d":"94.00"},200.03,"<1","N/A","http://selleckchem.com/products/LY2784544.html","C23H25ClFN7O","free base","N/A","CC1=N[NH]C(=C1)NC2=N[N]3C(=C(C)N=C3C(=C2)CN4CCOCC4)CC5=CC=C(Cl)C=C5F",3.938,4,2,6]
["S2180","Ixazomib (MLN2238)","e11","L3900-08","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.",361.03,"1072833-77-2",{"v":72,"d":"72.00"},199.43,"<1","N/A","http://selleckchem.com/products/MLN-2238.html","C14H19BCl2N2O4","Free Base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B(O)O",3.344,2,2,7]
["S2181","Ixazomib Citrate (MLN9708) Analogue","f11","L3900-08","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.",517.12,"1201902-80-8",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://selleckchem.com/products/MLN9708.html","C20H23BCl2N2O9","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)CC(CC(O)=O)(O2)C(O)=O",3.497,7,2,10]
["S2182","SB743921 HCl","g11","L3900-08","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.",553.52,"940929-33-9",{"v":111,"d":"111.00"},200.53,{"v":22,"d":"22.00"},39.75,"http://selleckchem.com/products/SB-743921.html","C31H33N2O3.HCl","Hydrochloride","N/A","Cl.CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=C(CC3=CC=CC=C3)C(=O)C4=C(O2)C=C(Cl)C=C4",6.536,3,1,9]
["S2183","Infigratinib (BGJ398)","h11","L3900-08","in 10mM DMSO","FGFR","Angiogenesis","Infigratinib (BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.",560.48,"872511-34-7",{"v":27,"d":"27.00"},48.17,"<1","N/A","http://www.selleck.cn/products/bgj398-nvp-bgj398.html","C26H31Cl2N7O3","Free Base","NVP-BGJ398","CCN1CCN(CC1)C2=CC=C(NC3=NC=NC(=C3)N(C)C(=O)NC4=C(Cl)C(=CC(=C4Cl)OC)OC)C=C2",5.342,5,2,8]
["S2185","Allitinib tosylate","a2","L3900-09","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Allitinib tosylate (AST-1306 TsOH, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.",621.08,"1050500-29-2",{"v":124,"d":"124.00"},199.65,"<1","N/A","https://www.selleckchem.com/products/allitinib-tosylate.html","C24H18ClFN4O2,C7H8O3S","Mesylate","AST-1306 TsOH, AST-6","CC1=CC=C(C=C1)[S](O)(=O)=O.FC2=CC(=CC=C2)COC3=CC=C(NC4=C5C=C(NC(=O)C=C)C=CC5=NC=N4)C=C3Cl",7.381,4,2,8]
["S2186","SB505124","b2","L3900-09","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.",{"v":335.4,"d":"335.40"},"694433-59-5",{"v":67,"d":"67.00"},199.76,"<1","N/A","http://selleckchem.com/products/sb-505124.html","C20H21N3O2","free base","N/A","CC1=CC=CC(=N1)C2=C(N=C([NH]2)C(C)(C)C)C3=CC4=C(OCO4)C=C3",4.609,4,1,3]
["S2187","Avasimibe (CI-1011)","c2","L3900-09","in 10mM DMSO","Acyltransferase,P450 (e.g. CYP17)","Metabolism","Avasimibe (CI-1011, PD-148515) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.",501.72,"166518-60-1",{"v":100,"d":"100.00"},199.31,"<1","N/A","http://selleckchem.com/products/Avasimibe(CI-1011).html","C29H43NO4S","free base","PD-148515","CC(C)C1=CC(=C(CC(=O)N[S](=O)(=O)OC2=C(C=CC=C2C(C)C)C(C)C)C(=C1)C(C)C)C(C)C",8.227,2,1,10]
["S2192","Sapitinib (AZD8931)","d2","L3900-09","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.",473.93,"848942-61-0",{"v":40,"d":"40.00"},{"v":84.4,"d":"84.40"},"<1","N/A","http://selleckchem.com/products/AZD8931.html","C23H25ClFN5O3","free base","N/A","CNC(=O)CN1CCC(CC1)OC2=C(OC)C=C3N=CN=C(NC4=C(F)C(=CC=C4)Cl)C3=C2",3.485,5,2,7]
["S2193","GSK461364","e2","L3900-09","in 10mM DMSO","PLK","Cell Cycle","GSK461364 (GSK461364A) inhibits purified Plk1 with Ki of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3.",{"v":543.6,"d":"543.60"},"929095-18-1",{"v":10,"d":"10.00"},{"v":18.4,"d":"18.40"},"<1","N/A","http://selleckchem.com/products/GSK461364.html","C27H28F3N5O2S","free base","GSK461364A","CC(OC1=C(SC(=C1)[N]2C=NC3=C2C=C(CN4CCN(C)CC4)C=C3)C(N)=O)C5=CC=CC=C5C(F)(F)F",5.125,3,1,8]
["S2194","R406","f2","L3900-09","in 10mM DMSO","Apoptosis related,FLT3,Syk","Angiogenesis","R406 is a potent Syk inhibitor with IC50 of 41 nM in cell-free assays, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 induces apoptosis. Phase 1.",628.63,"841290-81-1",{"v":100,"d":"100.00"},159.08,"<1","N/A","http://selleckchem.com/products/R406.html","C22H23FN6O5.C6H6O3S","Besylate","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC(=C(F)C=N2)NC3=NC4=C(OC(C)(C)C(=O)N4)C=C3)OC.O[S](=O)(=O)C5=CC=CC=C5",5.044,8,3,8]
["S2195","Lexibulin (CYT997)","g2","L3900-09","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.",434.53,"917111-44-5",{"v":86,"d":"86.00"},197.91,"<1","N/A","http://selleckchem.com/products/CYT997.html","C24H30N6O2","free base","SRI-32007","CCCC(NC1=C(C)C=NC(=N1)C2=CC(=C(NC(=O)NCC)C=C2)OC)C3=CC=CN=C3",3.744,5,3,9]
["S2198","SGI-1776 free base","h2","L3900-09","in 10mM DMSO","Apoptosis related,Autophagy,FLT3,Haspin Kinase,Pim","JAK/STAT","SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.",405.42,"1025065-69-3",{"v":81,"d":"81.00"},199.79,"<1","N/A","http://selleckchem.com/products/SGI-1776.html","C20H22F3N5O","free base","N/A","CN1CCC(CC1)CNC2=N[N]3C(=NC=C3C4=CC=CC(=C4)OC(F)(F)F)C=C2",5.206,3,1,6]
["S2199","Aliskiren Hemifumarate","a3","L3900-09","in 10mM DMSO","RAAS","Endocrinology & Hormones","Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.",609.83,"173334-58-2",{"v":100,"d":"100.00"},163.98,{"v":100,"d":"100.00"},163.98,"http://selleckchem.com/products/Aliskiren-hemifumarate.html","C30H53N3O6.1/2C4H4O4","fumarate salt","CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.COCCCOC2=C(OC)C=CC(=C2)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.OC(=O)\\C=C\\C(O)=O",1.735,12,8,40]
["S2201","BMS-794833","b3","L3900-09","in 10mM DMSO","c-Met,RON,VEGFR","Protein Tyrosine Kinase","BMS-794833 is a potent ATP competitive inhibitor of Met (c-Met)/VEGFR2 with IC50 of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1.",468.84,"1174046-72-0",{"v":94,"d":"94.00"},200.49,"<1","N/A","http://selleckchem.com/products/BMS-794833.html","C23H15ClF2N4O3","free base","N/A","NC1=NC=CC(=C1Cl)OC2=CC=C(NC(=O)C3=CNC=C(C3=O)C4=CC=C(F)C=C4)C=C2F",{"v":2.85,"d":"2.850"},4,3,5]
["S2214","AZ 960","c3","L3900-09","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.",354.36,"905586-69-8",{"v":71,"d":"71.00"},200.36,"<1","N/A","http://selleckchem.com/products/AZ-960.html","C18H16F2N6","free base","N/A","CC(NC1=NC(=C(F)C=C1C#N)NC2=N[NH]C(=C2)C)C3=CC=C(F)C=C3",4.495,2,3,5]
["S2215","DAPT (GSI-IX)","d3","L3900-09","in 10mM DMSO","Apoptosis related,Autophagy,Beta Amyloid,Secretase","Proteases","DAPT (GSI-IX, LY-374973) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.",432.46,"208255-80-5",{"v":86,"d":"86.00"},198.86,"<1","N/A","http://selleckchem.com/products/DAPT-GSI-IX.html","C23H26F2N2O4","free base","LY-374973","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC(C(=O)OC(C)(C)C)C2=CC=CC=C2",3.385,4,2,9]
["S2216","Mubritinib (TAK 165)","e3","L3900-09","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line.",468.47,"366017-09-6",{"v":13,"d":"13.00"},27.75,"<1","N/A","http://selleckchem.com/products/Mubritinib-TAK-165.html","C25H23F3N4O2","free base","N/A","FC(F)(F)C1=CC=C(\\C=C\\C2=NC(=CO2)COC3=CC=C(CCCC[N]4C=CN=N4)C=C3)C=C1",5.844,5,0,11]
["S2217","Irinotecan (CPT-11) HCl Trihydrate","f3","L3900-09","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.",677.18,"136572-09-3",{"v":100,"d":"100.00"},147.67,{"v":1,"d":"1.00"},1.48,"http://selleckchem.com/products/Irinotecan-Hcl-Trihydrate-Campto.html","C33H38N4O6.HCl.3H2O","HCl & trihydrat","CPT-11 HCl Trihydrate","O.O.O.Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=CC=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C15)C(O)(CC)C(=O)OC4",3.446,6,0,5]
["S2219","Momelotinib (CYT387)","g3","L3900-09","in 10mM DMSO","Apoptosis related,Autophagy,JAK","JAK/STAT","Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.",414.46,"1056634-68-4",{"v":74,"d":"74.00"},178.55,"<1","N/A","http://selleckchem.com/products/Cyt387.html","C23H22N6O2","free base","LM-1149 , CYT11387","O=C(NCC#N)C1=CC=C(C=C1)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.857,4,2,6]
["S2220","SB590885","h3","L3900-09","in 10mM DMSO","Raf","MAPK","SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM in a cell-free assay, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.",453.54,"405554-55-4",{"v":5,"d":"5.00"},11.02,"<1","N/A","http://selleckchem.com/products/SB590885.html","C27H27N5O2","free base","N/A","CN(C)CCOC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=C\\4C(=C3)CCC4=N\\O)C5=CC=NC=C5",4.503,4,1,7]
["S2224","UK 383367","a4","L3900-09","in 10mM DMSO","Procollagen C Proteinase","Metabolism","UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.",324.38,"348622-88-8",{"v":65,"d":"65.00"},200.38,"<1","N/A","http://selleckchem.com/products/UK-383367.html","C15H24N4O4","free base","N/A","NC(=O)C1=NOC(=N1)C(CCCC2CCCCC2)CC(=O)NO",1.731,5,2,8]
["S2226","Idelalisib","b4","L3900-09","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.",415.42,"870281-82-6",{"v":83,"d":"83.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/CAL-101.html","C22H18FN7O","free base","CAL-101, GS-1101","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=NC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)F",3.624,5,2,5]
["S2228","Belnacasan (VX-765)","c4","L3900-09","in 10mM DMSO","Caspase","Apoptosis","Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.",{"v":509,"d":"509.00"},"273404-37-8",{"v":100,"d":"100.00"},196.46,"<1","N/A","http://selleckchem.com/products/VX-765.html","C24H33ClN4O6","free base","N/A","CCOC1OC(=O)CC1NC(=O)C2CCCN2C(=O)C(NC(=O)C3=CC(=C(N)C=C3)Cl)C(C)(C)C",1.698,6,3,8]
["S2229","Eltrombopag (SB497115) Olamine","d4","L3900-09","in 10mM DMSO","TpoR","Immunology & Inflammation","Eltrombopag Olamine (SB-497115-GR, Revolade, Promacta,Promacta Olamine) is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).",564.63,"496775-62-3",{"v":89,"d":"89.00"},157.63,"<1","N/A","http://selleckchem.com/products/Eltrombopag-SB-497115-GR.html","C29H36N6O6","diolamine","SB-497115-GR, Revolade, Promacta,Promacta Olamine","CC1=CC=C(C=C1C)N2N=C(C)C(=N/NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(O)=O)/C2=O.NCCO.NCCO",-0.151,4,6,7]
["S2230","Galunisertib (LY2157299)","e4","L3900-09","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Galunisertib (LY2157299) is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay. Phase 2/3.",369.42,"700874-72-2",{"v":74,"d":"74.00"},200.31,"<1","N/A","http://selleckchem.com/products/ly2157299.html","C22H19N5O","free base","N/A","CC1=CC=CC(=N1)C2=N[N]3CCCC3=C2C4=CC=NC5=C4C=C(C=C5)C(N)=O",3.095,4,1,3]
["S2231","Telatinib","f4","L3900-09","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. Phase 2.",409.83,"332012-40-5",{"v":82,"d":"82.00"},200.08,"<1","N/A","http://selleckchem.com/products/Telatinib-BAY-57-9352.html","C20H16ClN5O3","free base","BAY 57-9352","CNC(=O)C1=NC=CC(=C1)COC2=NN=C(NC3=CC=C(Cl)C=C3)C4=C2OC=C4",3.861,6,2,6]
["S2233","Esomeprazole sodium","g4","L3900-09","in 10mM DMSO","ATPase","Transmembrane Transporters","Esomeprazole Sodium((S)-Omeprazole sodium, (-)-Omeprazole sodium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.",{"v":367.4,"d":"367.40"},"161796-78-7",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://selleckchem.com/products/esomeprazole-sodium.html","C17H18N3O3S.Na","Sodium salt","(S)-Omeprazole sodium, (-)-Omeprazole sodium","COC1=CC=C2[N]([Na])C(=NC2=C1)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S2235","Volasertib (BI 6727)","h4","L3900-09","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.",618.81,"755038-65-4",{"v":20,"d":"20.00"},32.32,"<1","N/A","http://selleckchem.com/products/BI6727-Volasertib.html","C34H50N8O3","free base","N/A","CCC1N(C(C)C)C2=C(C=NC(=N2)NC3=CC=C(C=C3OC)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)N(C)C1=O",4.838,5,2,10]
["S2238","Palomid 529 (P529)","a5","L3900-09","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.",406.43,"914913-88-5",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/Palomid-529-P529.html","C24H22O6","free base","SG 00529","COC1=CC=C(COC2=C(OC)C=C3C(=C2)OC(=O)C4=C3C=CC(=C4)C(C)O)C=C1",4.257,5,1,6]
["S2243","Degrasyn (WP1130)","b5","L3900-09","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,DUB","Angiogenesis","Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.",384.27,"856243-80-6",{"v":77,"d":"77.00"},200.38,"<1","N/A","http://selleckchem.com/products/WP1130.html","C19H18BrN3O","free base","N/A","CCCC(NC(=O)/C(=C/C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",4.546,2,1,6]
["S2244","AR-42","c5","L3900-09","in 10mM DMSO","HDAC","Epigenetics","AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.",312.36,"935881-37-1",{"v":63,"d":"63.00"},201.69,"<1","N/A","http://selleckchem.com/products/AR-42-HDAC-42.html","C18H20N2O3","free base","HDAC-42","CC(C)C(C(=O)NC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",2.834,2,2,5]
["S2246","Abiraterone Acetate (CB7630)","d5","L3900-09","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Abiraterone Acetate (CB7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.",391.55,"154229-18-2",{"v":20,"d":"20.00"},51.08,"<1","N/A","http://www.selleck.cn/products/Abiraterone-Acetate-CB7630.html","C26H33NO2","Acetate","CB7630, CB-7630","CC(=O)OC1CCC2(C)C3CCC4(C)C(CC=C4C5=CC=CN=C5)C3CC=C2C1",4.602,3,0,3]
["S2247","Buparlisib (BKM120)","e5","L3900-09","in 10mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.",410.39,"944396-07-0",{"v":82,"d":"82.00"},199.81,"<1","N/A","http://selleckchem.com/products/BKM-120.html","C18H21F3N6O2","free base","NVP-BKM120","NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F",2.342,5,1,4]
["S2248","Silmitasertib (CX-4945)","f5","L3900-09","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase","Metabolism","Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.",349.77,"1009820-21-6",{"v":16,"d":"16.00"},45.74,"<1","N/A","http://selleckchem.com/products/cx-4945-silmitasertib.html","C19H12ClN3O2","free base","N/A","OC(=O)C1=CC2=C(C=C1)C3=CN=CC=C3C(=N2)NC4=CC(=CC=C4)Cl",4.157,3,1,3]
["S2250","(-)-Epigallocatechin Gallate","g5","L3900-09","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2258","Esculin","h5","L3900-09","in 10mM DMSO","Others","Others","Esculin (Aesculin) is a glucoside found in horse chestnuts.",340.28,"531-75-9",{"v":68,"d":"68.00"},199.84,{"v":2,"d":"2.00"},5.88,"http://selleckchem.com/products/Aesculin(Esculin).html","C15H16O9","free base","Aesculin","OCC1OC(OC2=C(O)C=C3OC(=O)C=CC3=C2)C(O)C(O)C1O",-0.514,4,5,3]
["S2261","Andrographolide","a6","L3900-09","in 10mM DMSO","NF-κB","NF-κB","Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.",350.45,"5508-58-7",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/Andrographolide.html","C20H30O5","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C\\3C(O)COC3=O)C(=C)CCC12",2.056,2,3,3]
["S2262","Apigenin (LY 080400)","b6","L3900-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Apigenin (NSC 83244, LY 080400) is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.",270.24,"520-36-5",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Apigenin.html","C15H10O5","free base","NSC 83244","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",{"v":2.41,"d":"2.410"},2,3,1]
["S2264","Artemether","c6","L3900-09","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.",298.37,"71963-77-4",{"v":60,"d":"60.00"},201.09,"<1","N/A","http://selleckchem.com/products/Artemether(SM-224).html","C16H26O5","free base","SM-224, CGP 56696","COC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3",2.029,5,0,1]
["S2265","Artesunate (WR-256283)","d6","L3900-09","in 10mM DMSO","ADC Cytotoxin,STAT","JAK/STAT","Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.",384.42,"88495-63-0",{"v":77,"d":"77.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/Artesunate.html","C19H28O8","free base","WR-256283","CC1CCC2C(C)C(OC3OC4(C)CCC1C23OO4)OC(=O)CCC(O)=O",1.845,7,0,5]
["S2268","Baicalein","e6","L3900-09","in 10mM DMSO","P450 (e.g. CYP17),PREP","Metabolism","Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.",270.24,"491-67-8",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Baicalein.html","C15H10O5","free base","N/A","OC1=C(O)C(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)O",{"v":2.41,"d":"2.410"},2,3,1]
["S2269","Baicalin (NSC-661431)","f6","L3900-09","in 10mM DMSO","GABA Receptor,PREP","Neuronal Signaling","Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.",446.36,"21967-41-9",{"v":89,"d":"89.00"},199.39,"<1","N/A","http://selleckchem.com/products/Baicalin.html","C21H18O11","free base","N/A","OC1C(O)C(OC(C1O)C(O)=O)OC2=C(O)C(=C3C(=O)C=C(OC3=C2)C4=CC=CC=C4)O",0.608,5,5,4]
["S2271","Berberine chloride (NSC 646666)","g6","L3900-09","in 10mM DMSO","Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase","Microbiology","Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.",371.81,"633-65-8",{"v":40,"d":"40.00"},107.58,"<1","N/A","http://selleckchem.com/products/Berberine-Hydrochloride.html","C20H18NO4.Cl","chloride","Natural Yellow 18 chloride","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4",1.289,4,0,2]
["S2276","Bilobalide","h6","L3900-09","in 10mM DMSO","Others","Others","Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.",{"v":326.3,"d":"326.30"},"33570-04-6",{"v":65,"d":"65.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Bilobalide.html","C15H18O8","free base","N/A","CC(C)(C)C1(O)CC2OC(=O)CC23C(=O)OC4OC(=O)C(O)C134",-0.641,6,1,1]
["S2277","Caffeic Acid","a7","L3900-09","in 10mM DMSO","Lipoxygenase,TRP Channel","Transmembrane Transporters","Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).",180.16,"331-39-5",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/Caffeic-acid.html","C9H8O4","free base","N/A","OC(=O)/C=C/C1=CC=C(O)C(=C1)O",1.443,1,2,2]
["S2280","Chlorogenic Acid","b7","L3900-09","in 10mM DMSO","Others","Others","Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.",354.31,"327-97-9",{"v":71,"d":"71.00"},200.39,{"v":18,"d":"18.00"},{"v":50.8,"d":"50.80"},"http://selleckchem.com/products/Chlorogenic-acid.html","C16H18O9","free base","NSC 407296, Heriguard","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S2283","Cinchonine(LA40221)","c7","L3900-09","in 10mM DMSO","5-alpha Reductase","Angiogenesis","Cinchonine (LA40221) is an alkaloid and a stereoisomer and pseudo-enantiomer of cinchonidine.",{"v":294.4,"d":"294.40"},"118-10-5",{"v":9,"d":"9.00"},30.57,"N/A","N/A","http://selleckchem.com/products/cinchonine.html","C19H22N2O","free base","N/A","OC(C1CC2CCN1CC2C=C)C3=CC=NC4=CC=CC=C34",{"v":2.75,"d":"2.750"},1,1,3]
["S2284","Colchicine (NSC 757)","d7","L3900-09","in 10mM DMSO","Microtubule Associated","Cell Cycle","Colchicine (NSC 757, Colchineos, Colchisol, Colcin) is a microtubule polymerization inhibitor with an IC50 of 3 nM.",399.44,"64-86-8",{"v":80,"d":"80.00"},200.28,{"v":80,"d":"80.00"},200.28,"http://selleckchem.com/products/colchicine.html","C22H25NO6","free base","Colchineos, Colchisol, Colcin,NSC 757","COC1=CC=C2C(=CC1=O)C(CCC3=C2C(=C(OC)C(=C3)OC)OC)NC(C)=O",2.044,6,1,5]
["S2286","Cyclosporin A (NSC 290193)","e7","L3900-09","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Complement System,Immunology & Inflammation related,phosphatase","Immunology & Inflammation","Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.",1202.61,"59865-13-3",{"v":100,"d":"100.00"},83.15,"<1","N/A","http://selleckchem.com/products/Cyclosporin-A(Cyclosporine-A).html","C62H111N11O12","free base","Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193","CCC1NC(=O)C(C(O)C(C)C\\C=C\\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C",4.333,11,5,15]
["S2287","Cytisine","f7","L3900-09","in 10mM DMSO","AChR","Neuronal Signaling","Cytisine (Baphitoxine, Sophorine) is a nicotinic acetylcholine receptor agonist.",190.24,"485-35-8",{"v":38,"d":"38.00"},199.75,{"v":38,"d":"38.00"},199.75,"http://selleckchem.com/products/Cytisine(Baphitoxine,-Sophorine).html","C11H14N2O","free base","Baphitoxine,Sophorine","O=C1C=CC=C2C3CNCC(C3)CN12",-0.338,1,1,0]
["S2289","Daidzin","g7","L3900-09","in 10mM DMSO","Dehydrogenase","Metabolism","Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside), a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).",416.38,"552-66-9",{"v":83,"d":"83.00"},199.34,"<1","N/A","http://selleckchem.com/products/Daidzin.html","C21H20O9","Free Base","Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside","OCC1OC(OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",0.452,4,5,4]
["S2290","Dihydroartemisinin (DHA)","h7","L3900-09","in 10mM DMSO","Apoptosis related,Autophagy,NF-κB","NF-κB","Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.",284.35,"71939-50-9",{"v":56,"d":"56.00"},196.94,"<1","N/A","http://selleckchem.com/products/Dihydroartemisinin(DHA).html","C15H24O5","free base","Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol","CC1CCC2C(C)C(O)OC3OC4(C)CCC1C23OO4",1.621,4,0,0]
["S2295","Emodin","a8","L3900-09","in 10mM DMSO","Dehydrogenase","Metabolism","Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).",270.24,"518-82-1",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Emodin.html","C15H10O5","free base","N/A","CC1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(O)C=C3O)C2=O",2.568,2,3,0]
["S2298","Fisetin","b8","L3900-09","in 10mM DMSO","Sirtuin","Epigenetics","Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.",286.24,"528-48-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","http://selleckchem.com/products/Fisetin(Fustel).html","C15H10O6","free base","N/A","OC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC(=C(O)C=C3)O)O",1.872,2,4,1]
["S2302","Glycyrrhizin (NSC 167409)","c8","L3900-09","in 10mM DMSO","Dehydrogenase,High-mobility Group,MAO","Metabolism","Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).",822.93,"1405-86-3",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Glycyrrhizic-acid.html","C42H62O16","free base","N/A","CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",2.417,8,5,7]
["S2303","Gossypol Acetate","d8","L3900-09","in 10mM DMSO","Dehydrogenase","Metabolism","Gossypol Acetate (Gossypol Acetic acid, Pogosin, AT101) is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.",578.61,"12542-36-8",{"v":100,"d":"100.00"},172.83,"<1","N/A","https://www.selleckchem.com/products/gossypol-acetate.html","C32H34O10","Acetate","Gossypol Acetic acid, Pogosin, AT101","CC(C)C1=C2C=C(C)C(=C(O)C2=C(C=O)C(=C1O)O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C.CC(O)=O",6.388,3,6,5]
["S2305","Grape Seed Extract","e8","L3900-09","in 10mM DMSO","Others","Others","Grape Seed Extract are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs.","N/A","84929-27-1",{"v":94,"d":"94.00"},{"v":10,"d":"10.00"},"<1","N/A","http://selleckchem.com/products/Grape-Seed-Extract.html","N/A","Polyphenols","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S2308","Hesperetin","f8","L3900-09","in 10mM DMSO","Histamine Receptor,TGF-beta/Smad","TGF-beta/Smad","Hesperetin is a bioflavonoid and, to be more specific, a flavanone.",302.27,"520-33-2",{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/Hesperetin.html","C16H14O6","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.357,3,3,2]
["S2309","Hesperidin","g8","L3900-09","in 10mM DMSO","Others","Others","Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits.",610.56,"520-26-3",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/Hesperidin.html","C28H34O15","free base","Cirantin","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",-0.431,7,8,7]
["S2310","Honokiol (NSC 293100)","h8","L3900-09","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2311","Hyodeoxycholic acid (HDCA)","a9","L3900-09","in 10mM DMSO","GPCR19","GPCR & G Protein","Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.",392.57,"83-49-8",{"v":78,"d":"78.00"},198.69,"<1","N/A","http://selleckchem.com/products/Hyodeoxycholic-acid(HDCA).html","C24H40O4","free base","NSC 60672","CC(CCC(O)=O)C1CCC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C",4.014,1,2,4]
["S2312","Icariin","b9","L3900-09","in 10mM DMSO","PDE","Metabolism","Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.",676.66,"489-32-7",{"v":50,"d":"50.00"},73.89,"<1","N/A","http://selleckchem.com/products/Icariin.html","C33H40O15","free base","N/A","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O2)C(=C(OC5OC(CO)C(O)C(O)C5O)C=C4O)CC=C(C)C",0.983,7,8,9]
["S2313","Indole-3-carbinol","c9","L3900-09","in 10mM DMSO","NF-κB","NF-κB","Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.",147.18,"700-06-1",{"v":29,"d":"29.00"},197.04,{"v":7,"d":"7.00"},47.56,"http://selleckchem.com/products/Indole-3-carbinol.html","C9H9NO","free base","N/A","OCC1=C[NH]C2=C1C=CC=C2",1.518,0,2,1]
["S2314","Kaempferol (NSC 407289)","d9","L3900-09","in 10mM DMSO","Estrogen/progestogen Receptor,Fatty Acid Synthase","Endocrinology & Hormones","Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.",286.23,"520-18-3",{"v":57,"d":"57.00"},199.14,"<1","N/A","http://selleckchem.com/products/Kaempferol.html","C15H10O6","free base","Robigenin","OC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.872,2,4,1]
["S2316","Kinetin","e9","L3900-09","in 10mM DMSO","Others","Others","Kinetin (6-Furfuryladenine) is a type of cytokinin, a class of plant hormone that promotes cell division.",215.21,"525-79-1",{"v":8,"d":"8.00"},37.17,"<1","N/A","http://selleckchem.com/products/Kinetin(6-Furfuryladenine).html","C10H9N5O","free base","6-Furfuryladenine","C(NC1=NC=NC2=C1[NH]C=N2)C3=CC=CO3",0.875,4,2,3]
["S2317","L-(+)-Rhamnose Monohydrate","f9","L3900-09","in 10mM DMSO","Others","Others","L(+)-Rhamnose (Rham) is a naturally-occurring deoxy sugar that is found primarily in plants and some bacteria.",182.17,"10030-85-0",{"v":36,"d":"36.00"},197.62,{"v":36,"d":"36.00"},197.62,"http://selleckchem.com/products/l-positive-rotation-rhamnose-monohydrate.html","C6H12O5.H2O","Monohydrate","N/A","O.CC1OC(O)C(O)C(O)C1O",-1.833,1,3,0]
["S2318","Lappaconitine","g9","L3900-09","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc.",{"v":584.7,"d":"584.70"},"32854-75-4",{"v":16,"d":"16.00"},27.36,"N/A","N/A","http://selleckchem.com/products/lappaconitine.html","C32H44N2O8","free base","N/A","CCN1CC2(CCC(OC)C34C2CC(C13)C5(O)CC(OC)C6CC4C5(O)C6OC)OC(=O)C7=CC=CC=C7NC(C)=O",0.029,6,1,8]
["S2320","Luteolin","h9","L3900-09","in 10mM DMSO","ADC Cytotoxin,PDE","Metabolism","Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.",286.24,"491-70-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/luteolin.html","C15H10O6","free base","Luteoline, Luteolol, Digitoflavone","OC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=C(O)C(=C3)O)O",2.168,2,4,1]
["S2321","Magnolol","a10","L3900-09","in 10mM DMSO","Fungal,NF-κB","NF-κB","Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.",266.33,"528-43-8",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Magnolol(2,2-Bichavicol).html","C18H18O2","free base","NSC 293099","OC1=C(C=C(CC=C)C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2323","Methyl-Hesperidin","b10","L3900-09","in 10mM DMSO","Akt,PKC","PI3K/Akt/mTOR","Methyl Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin.",624.59,"11013-97-1",{"v":100,"d":"100.00"},155.62,{"v":100,"d":"100.00"},155.62,"http://selleckchem.com/products/Methyl-Hesperidin.html","C29H36O15","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(OC)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",{"v":-0.79,"d":"-0.790"},7,8,7]
["S2329","Naringin","c10","L3900-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.",580.53,"10236-47-2",{"v":100,"d":"100.00"},172.26,"<1","N/A","http://selleckchem.com/products/Naringin(Naringoside).html","C27H32O14","free base","Naringoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C=C5)O)C(O)C(O)C1O",-0.415,6,8,6]
["S2334","Oleanolic Acid","d10","L3900-09","in 10mM DMSO","Antiviral","Microbiology","Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.",{"v":456.7,"d":"456.70"},"508-02-1",{"v":21,"d":"21.00"},45.98,"<1","N/A","http://selleckchem.com/products/Oleanolic-Acid(Caryophyllin).html","C30H48O3","free base","Caryophyllin","CC1(C)CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",6.282,1,1,1]
["S2335","Oridonin (NSC-250682)","e10","L3900-09","in 10mM DMSO","Akt,Bacterial","PI3K/Akt/mTOR","Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.",364.43,"28957-04-2",{"v":72,"d":"72.00"},197.57,"<1","N/A","http://selleckchem.com/products/Oridonin(Isodonol).html","C20H28O6","free base","Isodonol, Rubescenin","CC1(C)CCC(O)C23COC(O)(C(O)C12)C45C(O)C(CCC34)C(=C)C5=O",{"v":0.2,"d":"0.200"},2,3,0]
["S2336","Orotic acid (6-Carboxyuracil)","f10","L3900-09","in 10mM DMSO","Others","Others","Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.",{"v":156.1,"d":"156.10"},"65-86-1",{"v":2,"d":"2.00"},12.81,"<1","N/A","http://selleckchem.com/products/Orotic-acid(6-Carboxyuracil).html","C5H4N2O4","free base","N/A","OC(=O)C1=CC(=O)NC(=O)N1",-1.152,3,2,1]
["S2337","Osthole","g10","L3900-09","in 10mM DMSO","Others","Others","Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.",244.29,"484-12-8",{"v":49,"d":"49.00"},200.58,"<1","N/A","http://selleckchem.com/products/Osthole(Osthol).html","C15H16O3","free base","Osthol","COC1=CC=C2C=CC(=O)OC2=C1CC=C(C)C",{"v":3.74,"d":"3.740"},3,0,3]
["S2341","(-)-Parthenolide","h10","L3900-09","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2344","Piperine","a11","L3900-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.",285.34,"94-62-2",{"v":57,"d":"57.00"},199.76,"<1","N/A","http://selleckchem.com/products/Piperine(1-Piperoylpiperidine).html","C17H19NO3","free base","1-Piperoylpiperidine","O=C(\\C=C\\C=C\\C1=CC2=C(OCO2)C=C1)N3CCCCC3",2.864,3,0,3]
["S2346","Puerarin","b11","L3900-09","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.",416.38,"3681-99-0",{"v":86,"d":"86.00"},206.54,"<1","N/A","http://selleckchem.com/products/Puerarin(Kakonein).html","C21H20O9","free base","Kakonein","OCC1OC(OC2=C(O)C=CC3=C2OC=C(C3=O)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S2347","Quercetin Dihydrate","c11","L3900-09","in 10mM DMSO","PI3K,Sirtuin","PI3K/Akt/mTOR","Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.",338.27,"6151-25-3",{"v":67,"d":"67.00"},198.07,"<1","N/A","http://selleckchem.com/products/Quercetin-dihydrate(Sophoretin).html","C15H10O7.2H2O","Dihydrate","Sophoretin","O.O.OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",1.216,2,5,1]
["S2350","Rutin","d11","L3900-09","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1","N/A","http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2357","Silibinin (NSC 651520)","e11","L3900-09","in 10mM DMSO","Others","Others","Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.",482.44,"22888-70-6",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silibinin(Silybin).html","C25H22O10","free base","Silybin, Silibinin A, Silymarin I, Flavobin","COC1=CC(=CC=C1O)C2OC3=CC(=CC=C3OC2CO)C4OC5=CC(=CC(=C5C(=O)C4O)O)O",2.592,5,5,4]
["S2358","Silymarin","f11","L3900-09","in 10mM DMSO","Antioxidant","Angiogenesis","Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.",482.44,"65666-07-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silymarin(Silybin-B).html","C25H22O10","free base","Silybin B","COC1=CC(=CC=C1O)C2OC3=CC=C(C=C3OC2CO)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S2359","Sinomenine","g11","L3900-09","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.",329.39,"115-53-7",{"v":65,"d":"65.00"},197.33,{"v":65,"d":"65.00"},197.33,"http://selleckchem.com/products/Sinomenine(Cucoline).html","C19H23NO4","free base","Cucoline, Kukoline","COC1=CC2C3CC4=C(C(=C(OC)C=C4)O)C2(CCN3C)CC1=O",1.674,3,1,2]
["S2363","Tangeretin","h11","L3900-09","in 10mM DMSO","Antioxidant","Apoptosis","Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.",372.37,"481-53-8",{"v":8,"d":"8.00"},21.48,"<1","N/A","http://selleckchem.com/products/Tangeretin(Tangeritin).html","C20H20O7","free base","Tangeritin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.054,7,0,6]
["S2365","Tanshinone IIA","a2","L3900-10","in 10mM DMSO","Lipase","Metabolism","Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.",294.34,"568-72-9",{"v":5,"d":"5.00"},16.99,"<1","N/A","http://selleckchem.com/products/Tanshinone-IIA(Tanshinone-B).html","C19H18O3","free base","Tanshinone B","CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C",{"v":4.66,"d":"4.660"},3,0,0]
["S2369","Troxerutin","b2","L3900-10","in 10mM DMSO","NLR,ROS","Immunology & Inflammation","Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.",742.68,"7085-55-4",{"v":100,"d":"100.00"},134.65,{"v":100,"d":"100.00"},134.65,"http://selleckchem.com/products/Troxerutin.html","C33H42O19","free base","N/A","CC1OC(OCC2OC(OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(OCCO)C=C5)OCCO)C(O)C(O)C2O)C(O)C(O)C1O",{"v":-2.1,"d":"-2.100"},9,10,15]
["S2370","Ursolic Acid","c2","L3900-10","in 10mM DMSO","Others","Others","Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.",{"v":456.7,"d":"456.70"},"77-52-1",{"v":91,"d":"91.00"},199.26,"<1","N/A","http://selleckchem.com/products/Ursolic-acid(Malol).html","C30H48O3","free base","NSC 167406, NSC-4060, Prunol, Urson, Malol","CC1CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",6.327,1,1,1]
["S2374","5-hydroxytryptophan (5-HTP)","d2","L3900-10","in 10mM DMSO","Others","Others","5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.",220.22,"56-69-9",{"v":44,"d":"44.00"},{"v":199.8,"d":"199.80"},{"v":4,"d":"4.00"},18.16,"http://selleckchem.com/products/5-hydroxytryptophan(5-HTP).html","C11H12N2O3","free base","NSC-92523","NC(CC1=C[NH]C2=CC=C(O)C=C12)C(O)=O",-1.554,1,3,3]
["S2381","D-Mannitol","e2","L3900-10","in 10mM DMSO","Others","Others","D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.",182.17,"69-65-8",{"v":36,"d":"36.00"},197.62,{"v":36,"d":"36.00"},197.62,"http://selleckchem.com/products/D-Mannitol(Osmitrol).html","C6H14O6","free base","Osmitrol","OCC(O)C(O)C(O)C(O)CO",-2.941,0,6,5]
["S2382","Evodiamine","f2","L3900-10","in 10mM DMSO","NF-κB","NF-κB","Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.",303.36,"518-17-2",{"v":12,"d":"12.00"},39.56,"<1","N/A","http://www.selleck.cn/products/Evodiamine(Isoevodiamine).html","C19H17N3O","Free Base","Isoevodiamine","CN1C2N(CCC3=C2[NH]C4=CC=CC=C34)C(=O)C5=C1C=CC=C5",3.673,1,1,0]
["S2383","Gastrodin","g2","L3900-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.",286.28,"62499-27-8",{"v":50,"d":"50.00"},174.65,"<1","N/A","http://selleckchem.com/products/Gastrodin(Gastrodine).html","C13H18O7","free base","Gastrodine","OCC1OC(OC2=CC=C(CO)C=C2)C(O)C(O)C1O",-0.947,2,5,4]
["S2386","Indirubin (NSC 105327)","h2","L3900-10","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Indirubin (NSC 105327) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.",262.26,"479-41-4",{"v":53,"d":"53.00"},202.09,"<1","N/A","http://selleckchem.com/products/Indirubin.html","C16H10N2O2","free base","NSC 105327","O=C1NC2=CC=CC=C2\\C1=C3/NC4=C(C=CC=C4)C3=O",1.876,2,2,0]
["S2388","L-carnitine","a3","L3900-10","in 10mM DMSO","Others","Others","L-carnitine (Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine) is constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.",{"v":161.2,"d":"161.20"},"541-15-1",{"v":12,"d":"12.00"},74.44,{"v":32,"d":"32.00"},198.51,"http://selleckchem.com/products/L-carnitine(Levocarnitine).html","C7H15NO3","quaternary-N  salt","Levocarnitine,Carnitor, vitamin BT, Karnitin,L(-)-Carnitine","C[N+](C)(C)CC(O)CC([O-])=O",{"v":-3.29,"d":"-3.290"},0,1,4]
["S2389","Naringin Dihydrochalcone","b3","L3900-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.",582.55,"18916-17-1",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://selleckchem.com/products/Naringin-Dihydrochalcone(Naringin-DC).html","C27H34O14","free base","N/A","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C(C(=O)CCC4=CC=C(O)C=C4)C(=C3)O)O)C(O)C(O)C1O",-0.032,5,9,9]
["S2391","Quercetin (NSC 9221)","c3","L3900-10","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src","Epigenetics","Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.",302.24,"117-39-5",{"v":61,"d":"61.00"},201.83,"<1","N/A","http://selleckchem.com/products/Quercetin(Sophoretin).html","C15H10O7","Free Base","Sophoretin, C.I. 75720","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S2393","Sorbitol","d3","L3900-10","in 10mM DMSO","Others","Others","Sorbitol (Glucitol) is a sugar alcohol and a sugar substitute.",182.17,"50-70-4",{"v":36,"d":"36.00"},197.62,{"v":36,"d":"36.00"},197.62,"http://selleckchem.com/products/Sorbitol(Glucitol).html","C6H14O6","free base","Glucitol","OCC(O)C(O)C(O)C(O)CO",-2.941,0,6,5]
["S2394","Naringenin","e3","L3900-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.",272.25,"480-41-1",{"v":54,"d":"54.00"},198.35,"<1","N/A","http://selleckchem.com/products/naringenin.html","C15H12O5","free base","NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["S2399","Dihydromyricetin","f3","L3900-10","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2403","Tetrandrine (NSC-77037)","g3","L3900-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.",622.75,"518-34-3",{"v":7,"d":"7.00"},11.24,"<1","N/A","http://www.selleck.cn/products/Tetrandrine-Fanchinine.html","C38H42N2O6","Free Base","Fanchinine, d-Tetrandrine","COC1=CC=C2CC3N(C)CCC4=CC(=C(OC)C(=C34)OC5=C(OC)C=C6CCN(C)C(CC7=CC=C(OC1=C2)C=C7)C6=C5)OC",7.218,6,0,4]
["S2404","Isoliquiritigenin","h3","L3900-10","in 10mM DMSO","Aldose Reductase","Metabolism","Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.",256.25,"961-29-5",{"v":12,"d":"12.00"},46.83,"<1","N/A","http://selleckchem.com/products/Isoliquiritigenin.html","C15H12O4","free base","N/A","OC1=CC=C(C=C1)\\C=C\\C(=O)C2=C(O)C=C(O)C=C2",2.975,1,3,3]
["S2407","Curcumol","a4","L3900-10","in 10mM DMSO","JAK","JAK/STAT","Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.",236.35,"4871-97-0",{"v":47,"d":"47.00"},198.86,"<1","N/A","http://selleckchem.com/products/Curcumol.html","C15H24O2","free base","N/A","CC(C)C1CC23OC1(O)CC(=C)C2CCC3C",2.786,1,0,1]
["S2410","Paeoniflorin (NSC 178886)","b4","L3900-10","in 10mM DMSO","COX,HIF","Immunology & Inflammation","Paeoniflorin (NSC 178886,Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin reduces COX-2 expression. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.",480.46,"23180-57-6",{"v":96,"d":"96.00"},199.81,{"v":96,"d":"96.00"},199.81,"http://selleckchem.com/products/paeoniflorin.html","C23H28O11","free base","NSC 178886,Peoniflorin","CC12CC3(O)OC(O1)C4(COC(=O)C5=CC=CC=C5)C3CC24OC6OC(CO)C(O)C(O)C6O",-1.283,6,4,7]
["S2411","Geniposide","c4","L3900-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis.",388.37,"24512-63-8",{"v":78,"d":"78.00"},200.84,{"v":78,"d":"78.00"},200.84,"http://selleckchem.com/products/geniposide.html","C17H24O10","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C1CC=C3CO",-2.066,5,5,6]
["S2412","Genipin","d4","L3900-10","in 10mM DMSO","Apoptosis related","Apoptosis","Genipin((+)-Genipin) is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.",226.23,"6902-77-8",{"v":45,"d":"45.00"},198.91,"<1","N/A","http://selleckchem.com/products/genipin.html","C11H14O5","free base","(+)-Genipin","COC(=O)C1=COC(O)C2C1CC=C2CO",-0.319,3,1,3]
["S2423","(S)-10-Hydroxycamptothecin","e4","L3900-10","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.",364.35,"19685-09-7",{"v":8,"d":"8.00"},21.96,"<1","N/A","http://selleckchem.com/products/10-hydroxycamptothecin.html","C20H16N2O5","free base","10-HCPT","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=CC(=CC=C5N=C34)O)C2=O",1.504,4,1,1]
["S2425","Apocynin (NSC 2146)","f4","L3900-10","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.",166.17,"498-02-2",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/apocynin-acetovanillone.html","C9H10O3","free base","Acetovanillone, NSC 209524","COC1=C(O)C=CC(=C1)C(C)=O",1.311,2,1,2]
["S2439","Guanosine","g4","L3900-10","in 10mM DMSO","Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.",283.24,"118-00-3",{"v":56,"d":"56.00"},197.71,"<1","N/A","http://selleckchem.com/products/guanosine.html","C10H13N5O5","free base","N/A","NC1=NC2=C(N=C[N]2C3OC(CO)C(O)C3O)C(=O)N1",{"v":-2.38,"d":"-2.380"},4,5,2]
["S2442","Inosine","h4","L3900-10","in 10mM DMSO","Others","Others","Inosine (NSC 20262, INO 495) is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.",268.23,"58-63-9",{"v":53,"d":"53.00"},197.59,{"v":47,"d":"47.00"},175.22,"http://selleckchem.com/products/inosine.html","C10H12N4O5","free base","NSC 20262, INO 495","OCC1OC(C(O)C1O)[N]2C=NC3=C2N=CNC3=O",-2.249,4,4,2]
["S2443","Tolbutamide (HLS 831)","a5","L3900-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.",270.35,"64-77-7",{"v":54,"d":"54.00"},199.74,"<1","N/A","http://selleckchem.com/products/tolbutamide.html","C12H18N2O3S","free base","HLS 831","CCCCNC(=O)N[S](=O)(=O)C1=CC=C(C)C=C1",2.336,3,2,5]
["S2446","Levosimendan","b5","L3900-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levosimendan(OR1259,OR1855,Simsndan) is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.",280.28,"141505-33-1",{"v":56,"d":"56.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/levosimendan.html","C14H12N6O","free base","OR1259,OR1855,Simsndan","CC1CC(=O)NN=C1C2=CC=C(NN=C(C#N)C#N)C=C2",1.486,3,2,3]
["S2448","Gambogic Acid","c5","L3900-10","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.",628.75,"2752-65-0",{"v":100,"d":"100.00"},159.05,"<1","N/A","http://selleckchem.com/products/gambogic-acid.html","C38H44O8","free base","Guttatic Acid, Guttic Acid, Beta-Guttiferrin","CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(=C2C=C1)O)C(=O)C4=CC5CC6C(C)(C)OC(C\\C=C(C)/C(O)=O)(C5=O)C46O3",6.957,6,1,8]
["S2449","Colforsin","d5","L3900-10","in 10mM DMSO","Autophagy,cAMP,FXR","GPCR & G Protein","Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.",{"v":410.5,"d":"410.50"},"66575-29-9",{"v":82,"d":"82.00"},199.76,"<1","N/A","http://selleckchem.com/products/forskolin.html","C22H34O7","free base","Forskolin, HL 362, Coleonol","CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C3(O)C(=O)CC(C)(OC13C)C=C",0.837,4,2,3]
["S2450","Equol","e5","L3900-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.",242.27,"531-95-3",{"v":48,"d":"48.00"},198.13,"<1","N/A","http://selleckchem.com/products/equol.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=CC(=CC=C3C2)O",3.211,1,2,1]
["S2451","Amantadine HCl","f5","L3900-10","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Amantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus.",{"v":187.7,"d":"187.70"},"665-66-7",{"v":38,"d":"38.00"},202.45,{"v":38,"d":"38.00"},202.45,"http://selleckchem.com/products/Amantadine-hydrochloride(Symmetrel).html","C10H17N.HCl","Hydrochloride","1-adamantanamine HCl","Cl.N[C]12CC3[CH2][CH](C[CH]([CH2]3)C1)C2",1.877,0,1,0]
["S2452","Amfebutamone (Bupropion) HCl","g5","L3900-10","in 10mM DMSO","AChR,Dopamine Receptor","Neuronal Signaling","Amfebutamone (Bupropion) HCl(Wellbutrin) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.",{"v":276.2,"d":"276.20"},"31677-93-7",{"v":8,"d":"8.00"},28.96,"<1","N/A","http://selleckchem.com/products/Amfebutamone-hydrochloride(Bupropion).html","C13H18ClNO.HCl","Hydrochloride","Wellbutrin","Cl.CC(NC(C)(C)C)C(=O)C1=CC=CC(=C1)Cl",3.501,1,1,4]
["S2454","Bupivacaine HCl","h5","L3900-10","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.",324.89,"18010-40-7",{"v":65,"d":"65.00"},200.07,{"v":23,"d":"23.00"},70.79,"http://selleckchem.com/products/Bupivacaine-hydrochloride(Marcain).html","C18H28N2O.HCl","Hydrochloride","N/A","Cl.CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.692,1,1,5]
["S2455","Bethanechol chloride","a6","L3900-10","in 10mM DMSO","AChR","Neuronal Signaling","Bethanechol chloride(Myocholine,Urecholine) is a selective muscarinic receptor agonist without any effect on nicotinic receptors.",196.68,"590-63-6",{"v":39,"d":"39.00"},198.29,{"v":39,"d":"39.00"},198.29,"http://selleckchem.com/products/Carbamyl-beta-methylcholine-chloride(Bethanechol-chloride).html","C7H17N2O2.Cl","quaternary-N Chloride salt","Myocholine,Urecholine","[Cl-].CC(C[N+](C)(C)C)OC(N)=O",-3.702,2,1,4]
["S2456","Chlorpromazine HCl","b6","L3900-10","in 10mM DMSO","Dopamine Receptor,Potassium Channel","Neuronal Signaling","Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.",355.33,"69-09-0",{"v":71,"d":"71.00"},199.81,{"v":71,"d":"71.00"},199.81,"http://selleckchem.com/products/Chlorpromazine-hydrochloride(Sonazine).html","C17H19ClN2S.HCl","Hydrochloride","Sonazine","Cl.CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",5.121,0,0,4]
["S2457","Clindamycin HCl","c6","L3900-10","in 10mM DMSO","Bacterial","Microbiology","Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.",461.44,"21462-39-5",{"v":92,"d":"92.00"},199.38,{"v":92,"d":"92.00"},199.38,"http://selleckchem.com/products/Clindamycin-hydrochloride(Dalacin).html","C18H33ClN2O5S.HCl","Hydrochloride","N/A","Cl.CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O)C(O)C2O",1.659,2,4,7]
["S2458","Clonidine HCl","d6","L3900-10","in 10mM DMSO","Adrenergic Receptor,Autophagy","Neuronal Signaling","Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.",{"v":266.5,"d":"266.50"},"4205-91-8",{"v":53,"d":"53.00"},198.87,{"v":53,"d":"53.00"},198.87,"http://selleckchem.com/products/Clonidine-hydrochloride(Catapres).html","C9H9Cl2N3.HCl","Hydrochloride","Kapvay","Cl.ClC1=C(NC2=NCCN2)C(=CC=C1)Cl",2.736,1,2,2]
["S2459","Clozapine","e6","L3900-10","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Clozapine (HF 1854, LX 100-129) is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.",326.82,"5786-21-0",{"v":65,"d":"65.00"},198.89,"<1","N/A","http://selleckchem.com/products/Clozapine(Clozaril).html","C18H19ClN4","free base","HF 1854, LX 100-129","CN1CCN(CC1)C2=NC3=C(NC4=C2C=CC=C4)C=CC(=C3)Cl",3.422,1,1,1]
["S2460","Pramipexole","f6","L3900-10","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.",211.33,"104632-26-0",{"v":42,"d":"42.00"},198.74,"<1","N/A","http://selleckchem.com/products/Pramipexole-Mirapex.html","C10H17N3S","Free Base","SND 919,Mirapexin,Sifrol,Mirapex","CCCNC1CCC2=C(C1)SC(=N2)N",1.383,1,2,3]
["S2461","Domperidone","g6","L3900-10","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.",425.91,"57808-66-9",{"v":48,"d":"48.00"},{"v":112.7,"d":"112.70"},"<1","N/A","http://selleckchem.com/products/Domperidone(Motilium).html","C22H24ClN5O2","free base","N/A","ClC1=CC2=C(C=C1)N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)N2",2.453,2,2,5]
["S2466","Estriol","h6","L3900-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estriol (NSC-12169) is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.",288.39,"50-27-1",{"v":57,"d":"57.00"},197.65,"<1","N/A","http://selleckchem.com/products/Estriol(Oestriol).html","C18H24O3","free base","NSC-12169","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CC(O)C2O",2.871,0,3,0]
["S2467","Famciclovir","a7","L3900-10","in 10mM DMSO","Antiviral","Microbiology","Famciclovir (BRL-42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.",321.34,"104227-87-4",{"v":64,"d":"64.00"},199.17,{"v":64,"d":"64.00"},199.17,"http://selleckchem.com/products/Famciclovir(Famvir).html","C14H19N5O4","free base","BRL-42810","CC(=O)OCC(CC[N]1C=NC2=CN=C(N)N=C12)COC(C)=O",-0.294,7,1,9]
["S2470","Fluocinolone Acetonide","b7","L3900-10","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor.",{"v":452.5,"d":"452.50"},"67-73-2",{"v":90,"d":"90.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Fluocinolone-acetonide(Flucort-N).html","C24H30F2O6","free base","Flucort-N","CC1(C)OC2CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CO",0.995,4,2,2]
["S2473","Hexestrol","c7","L3900-10","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Hexestrol (Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.",270.37,"84-16-2",{"v":42,"d":"42.00"},155.34,"<1","N/A","http://selleckchem.com/products/Hexestrol(Bibenzyl).html","C18H22O2","free base","Bibenzyl","CCC(C(CC)C1=CC=C(O)C=C1)C2=CC=C(O)C=C2",5.192,0,2,5]
["S2475","Imatinib (STI571)","d7","L3900-10","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571,Gleevec, Glivec, CGP057148B) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.",{"v":493.6,"d":"493.60"},"152459-95-5",{"v":33,"d":"33.00"},66.86,"<1","N/A","http://selleckchem.com/products/Imatinib(STI571).html","C29H31N7O","free base","STI571,Gleevec, Glivec, CGP057148B","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",{"v":4.22,"d":"4.220"},4,2,7]
["S2479","Lincomycin HCl","e7","L3900-10","in 10mM DMSO","Antibiotics for Mammalian Cell Culture,Anti-infection","Microbiology","Lincomycin  hydrochloride (Lincocin, NSC 70731,U10149A) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis.",{"v":443,"d":"443.00"},"859-18-7",{"v":89,"d":"89.00"},{"v":200.9,"d":"200.90"},{"v":89,"d":"89.00"},{"v":200.9,"d":"200.90"},"http://selleckchem.com/products/Lincomycin-hydrochloride(Lincocin).html","C18H34N2O6S.HCl","Hydrochloride","Lincocin, NSC 70731,U10149A","Cl.CCCC1CC(N(C)C1)C(=O)NC(C(C)O)C2OC(SC)C(O)C(O)C2O",0.454,2,5,7]
["S2480","Loperamide HCl","f7","L3900-10","in 10mM DMSO","Autophagy,Opioid Receptor","Neuronal Signaling","Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.",{"v":513.5,"d":"513.50"},"34552-83-5",{"v":22,"d":"22.00"},42.84,"<1","N/A","http://selleckchem.com/products/Loperamide-hydrochloride.html","C29H33ClN2O2.HCl","Hydrochloride","ADL 2-1294,R-18553 hydrochloride","Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.017,1,0,7]
["S2481","Manidipine","g7","L3900-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.",{"v":610.7,"d":"610.70"},"89226-50-6",{"v":122,"d":"122.00"},199.77,"<1","N/A","http://selleckchem.com/products/Manidipine(Manyper).html","C35H38N4O6","free base","CV-4093,(±)-Manidipine","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.058,4,1,12]
["S2482","Manidipine 2HCl","h7","L3900-10","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.",683.62,"89226-75-5",{"v":21,"d":"21.00"},30.72,"<1","N/A","http://selleckchem.com/products/Manidipine-dihydrochloride(CV-4093).html","C35H38N4O6.2HCl","Dihydrochloride","CV-4093","Cl.Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.822,4,1,12]
["S2484","Milrinone","a8","L3900-10","in 10mM DMSO","PDE","Metabolism","Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.",211.22,"78415-72-2",{"v":42,"d":"42.00"},198.84,"<1","N/A","http://selleckchem.com/products/Milrinone(Primacor).html","C12H9N3O","free base","Win 47203,Primacor","CC1=C(C=C(C#N)C(=O)N1)C2=CC=NC=C2",0.356,2,1,1]
["S2485","Mitoxantrone (NSC-301739) 2HCl","b8","L3900-10","in 10mM DMSO","Apoptosis related,COVID-19,PKC,Topoisomerase","DNA Damage/DNA Repair","Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.",{"v":517.4,"d":"517.40"},"70476-82-3",{"v":89,"d":"89.00"},172.01,{"v":89,"d":"89.00"},172.01,"http://selleckchem.com/products/Mitoxantrone-Hydrochloride.html","C22H29ClN4O6.2HCl","Dihydrochloride","NSC-301739 2HCl","Cl.Cl.OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C3=C(O)C=CC(=C3C2=O)O",0.832,2,8,12]
["S2487","Mycophenolic acid","c8","L3900-10","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dehydrogenase,Selection Antibiotics for Transfected Cell","Metabolism","Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.",320.34,"24280-93-1",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/Mycophenolic-acid(Mycophenolate).html","C17H20O6","free base","Mycophenolate, RS-61443","COC1=C(C)C2=C(C(=C1C\\C=C(/C)CCC(O)=O)O)C(=O)OC2",3.157,4,1,6]
["S2489","Nateglinide","d8","L3900-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Nateglinide (Starlix,A-4166,SDZ DJN 608) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.",317.42,"105816-04-4",{"v":63,"d":"63.00"},198.48,"<1","N/A","http://selleckchem.com/products/Nateglinide(Starlix).html","C19H27NO3","free base","Starlix,A-4166,SDZ DJN 608","CC(C)C1CCC(CC1)C(=O)NC(CC2=CC=CC=C2)C(O)=O",3.981,2,1,6]
["S2491","Nitrendipine","e8","L3900-10","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.",360.37,"39562-70-4",{"v":72,"d":"72.00"},199.79,"<1","N/A","http://selleckchem.com/products/Nitrendipine.html","C18H20N2O6","free base","Bayotensin","CCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC)C",2.115,4,1,7]
["S2493","Olanzapine","f8","L3900-10","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.",312.44,"132539-06-1",{"v":62,"d":"62.00"},198.44,"<1","N/A","http://selleckchem.com/products/Olanzapine(Zyprexa).html","C17H20N4S","free base","LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera","CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3",{"v":2.69,"d":"2.690"},1,1,1]
["S2494","Olopatadine HCl","g8","L3900-10","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Olopatadine HCl(ALO4943A,KW4679) is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine.",373.87,"140462-76-6",{"v":75,"d":"75.00"},{"v":200.6,"d":"200.60"},{"v":13,"d":"13.00"},34.77,"http://selleckchem.com/products/Olopatadine-hydrochloride(Opatanol).html","C21H23NO3.HCl","Hydrochloride","ALO4943A,KW4679","Cl.CN(C)CC\\C=C/1C2=C(COC3=C1C=C(CC(O)=O)C=C3)C=CC=C2",{"v":0.92,"d":"0.920"},2,0,5]
["S2496","Ozagrel","h8","L3900-10","in 10mM DMSO","P450 (e.g. CYP17),Prostaglandin Receptor","GPCR & G Protein","Ozagrel (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.",228.25,"82571-53-7",{"v":46,"d":"46.00"},201.53,"<1","N/A","http://selleckchem.com/products/Ozagrel.html","C13H12N2O2","free base","OKY-046","OC(=O)/C=C/C1=CC=C(C[N]2C=CN=C2)C=C1",1.604,2,0,4]
["S2497","Pancuronium dibromide","a9","L3900-10","in 10mM DMSO","AChR","Neuronal Signaling","Pancuronium dibromide(Pavulon) is a competitive nicotinic acetylcholine receptor antagonist, used as a muscle relaxant.",732.67,"15500-66-0",{"v":100,"d":"100.00"},136.49,{"v":100,"d":"100.00"},136.49,"http://selleckchem.com/products/Pancuronium-bromide(Pavulon).html","C35H60N2O4.2Br","di-quaternary-N bromide salt","Pavulon","[Br-].[Br-].CC(=O)OC1CC2CCC3C(CCC4(C)C3CC(C4OC(C)=O)[N+]5(C)CCCCC5)C2(C)CC1[N+]6(C)CCCCC6",-2.043,4,0,6]
["S2499","Phenoxybenzamine HCl","b9","L3900-10","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.",{"v":340.3,"d":"340.30"},"63-92-3",{"v":68,"d":"68.00"},199.82,{"v":17,"d":"17.00"},49.96,"http://selleckchem.com/products/Phenoxybenzamine-hydrochloride.html","C18H22ClNO.HCl","HCl","NSC 37448, NCI-c01661","Cl.CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2",{"v":4.96,"d":"4.960"},1,0,8]
["S2500","Propafenone HCl","c9","L3900-10","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.",{"v":377.9,"d":"377.90"},"34183-22-7",{"v":69,"d":"69.00"},182.59,"<1","N/A","http://selleckchem.com/products/Propafenone(Rytmonorm).html","C21H27NO3.HCl","Hydrochloride","N/A","CCCNCC(O)COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2",3.673,2,2,11]
["S2501","Pyrantel Pamoate","d9","L3900-10","in 10mM DMSO","Parasite","Microbiology","Pyrantel pamoate (Pyrantel Embonate), a broad-spectrum anthelmintic drug, is used to treat a number of parasitic worm infections.",594.69,"22204-24-6",{"v":100,"d":"100.00"},168.15,"<1","N/A","http://selleckchem.com/products/Pyrantel-pamoate(Pyrantel-embonate).html","C23H16O6.C11H14N2S","salt","Pyrantel Embonate","CN1CCCN=C1\\C=C\\C2=CC=CS2.OC(=O)C3=CC4=CC=CC=C4C(=C3O)CC5=C6C=CC=CC6=CC(=C5O)C(O)=O",6.203,3,2,6]
["S2502","Quinine HCl Dihydrate","e9","L3900-10","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.",396.91,"6119-47-7",{"v":79,"d":"79.00"},199.04,{"v":43,"d":"43.00"},108.34,"http://selleckchem.com/products/Quinine-hydrochloride-dihydrate.html","C20H24N2O2.HCl.2H2O","Hydrochloride dihydrate","N/A","O.O.Cl.COC1=CC2=C(C=C1)N=CC=C2C(O)C3CC4CCN3CC4C=C",2.701,2,1,4]
["S2503","Racecadotril","f9","L3900-10","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Racecadotril (Acetorphan) is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μM.",385.48,"81110-73-8",{"v":22,"d":"22.00"},57.07,"<1","N/A","http://selleckchem.com/products/Racecadotril(Acetorphan).html","C21H23NO4S","free base","Acetorphan","CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2",3.128,4,1,11]
["S2504","Ribavirin (ICN-1229)","g9","L3900-10","in 10mM DMSO","Antiviral","Microbiology","Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.",244.21,"36791-04-5",{"v":49,"d":"49.00"},200.65,{"v":49,"d":"49.00"},200.65,"http://selleckchem.com/products/Ribavirin(Copegus).html","C8H12N4O5","free base","NSC-163039, RTCA, Tribavirin","NC(=O)C1=N[N](C=N1)C2OC(CO)C(O)C2O",-2.745,4,4,3]
["S2505","Rosiglitazone (BRL-49653) maleate","h9","L3900-10","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",{"v":473.5,"d":"473.50"},"155141-29-0",{"v":94,"d":"94.00"},198.52,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-maleate.html","C18H19N3O3S.C4H4O4","Maleate","BRL-49653C","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=NC=CC=C3.OC(=O)\\C=C/C(O)=O",3.307,6,1,9]
["S2506","Roxithromycin","a10","L3900-10","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics","Microbiology","Roxithromycin (Roxl-150, Roxo, Surlid, Rulide, Biaxsig, Roxar, Roximycin, Roxomycin, Tirabicin, Coroxin,RU-28965) is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections.",837.07,"80214-83-1",{"v":167,"d":"167.00"},199.51,"<1","N/A","http://selleckchem.com/products/Roxithromycin(Roxl-150).html","C41H76N2O15","free base","Roxl-150, Roxo, Surlid, Rulide, Biaxsig, Roxar, Roximycin, Roxomycin, Tirabicin, Coroxin,RU-28965","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)/C(C)C(O)C1(C)O",1.619,11,3,13]
["S2508","Scopolamine (LSM-4015) HBr","b10","L3900-10","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.",384.26,"114-49-8",{"v":76,"d":"76.00"},197.78,{"v":76,"d":"76.00"},197.78,"http://selleckchem.com/products/Scopolamine-hydrobromide.html","C17H21NO4.HBr","Hydrobromide","LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide","Br.CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",1.314,3,1,5]
["S2509","Sotalol HCl","c10","L3900-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Sotalol(MJ-1999)  is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.",308.82,"959-24-0",{"v":61,"d":"61.00"},197.53,{"v":61,"d":"61.00"},197.53,"http://selleckchem.com/products/Sotalol-hydrochloride(Betapace).html","C12H20N2O3S.HCl","Hydrochloride","MJ-1999","Cl.CC(C)NCC(O)C1=CC=C(N[S](C)(=O)=O)C=C1",0.876,2,3,6]
["S2510","Spectinomycin 2HCl","d10","L3900-10","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis.",405.27,"21736-83-4",{"v":81,"d":"81.00"},199.87,{"v":81,"d":"81.00"},199.87,"http://selleckchem.com/products/Spectinomycin-hydrochloride.html","C14H24N2O7.2HCl","dihydrochloride","Actinospectacin","Cl.Cl.CNC1C(O)C(NC)C2OC3(O)C(OC(C)CC3=O)OC2C1O",-1.566,4,4,2]
["S2511","Sulfadoxine","e10","L3900-10","in 10mM DMSO","Anti-infection","Microbiology","Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.",310.33,"2447-57-6",{"v":62,"d":"62.00"},199.78,"<1","N/A","http://selleckchem.com/products/Sulfadoxine(Sulphadoxine).html","C12H14N4O4S","free base","Sulphadoxine","COC1=C(OC)C(=NC=N1)N[S](=O)(=O)C2=CC=C(N)C=C2",0.837,6,2,5]
["S2512","Tenoxicam","f10","L3900-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.",337.38,"59804-37-4",{"v":68,"d":"68.00"},201.55,"<1","N/A","http://selleckchem.com/products/Tenoxicam(Mobiflex).html","C13H11N3O4S2","free base","Ro-12-0068","CN1C(=C(O)C2=C(C=CS2)[S]1(=O)=O)C(=O)NC3=CC=CC=N3",0.454,4,2,2]
["S2515","Vardenafil HCl Trihydrate","g10","L3900-10","in 10mM DMSO","PDE","Metabolism","Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.",579.11,"330808-88-3",{"v":100,"d":"100.00"},172.68,{"v":10,"d":"10.00"},17.27,"http://selleckchem.com/products/Vardenafil(Vivanza).html","C23H32N6O4S.HCl.3H2O","Hydrochloride trihydrate","BAY38-9456","O.O.O.Cl.CCCC1=NC(=C2[N]1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(CC)CC4)C",2.109,6,1,8]
["S2519","Naphazoline HCl","h10","L3900-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.",246.74,"550-99-2",{"v":17,"d":"17.00"},{"v":68.9,"d":"68.90"},{"v":49,"d":"49.00"},198.59,"http://selleckchem.com/products/Naphazoline-hydrochloride-Naphcon.html","C14H14N2.HCl","Hydrochloride","N/A","Cl.C1CN=C(CC2=C3C=CC=CC3=CC=C2)N1",2.442,1,1,2]
["S2521","Epinephrine bitartrate","a11","L3900-10","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Epinephrine bitartrate (Adrenalinium) is an alpha- and beta-adrenergic receptor stimulator.",333.29,"51-42-3",{"v":67,"d":"67.00"},201.03,{"v":67,"d":"67.00"},201.03,"http://selleckchem.com/products/Epinephrine-bitartrate-Adrenalinium.html","C9H13NO3.C4H6O6","tartrate","Adrenalinium","CNCC(O)C1=CC(=C(O)C=C1)O.OC(C(O)C(O)=O)C(O)=O",-3.996,2,6,6]
["S2524","Phenytoin Sodium","b11","L3900-10","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Phenytoin Sodium (Aleviatin, Diphenylhydantoin sodium, Eptoin, Phenytoin soluble, Prompt; Phenytek,Dilantin sodium, Diphantoine) is an inactive voltage-gated sodium channel stabilizer.",274.25,"630-93-3",{"v":32,"d":"32.00"},116.68,{"v":3,"d":"3.00"},10.94,"http://selleckchem.com/products/Phenytoin-sodium-Dilantin.html","C15H11N2NaO2","Sodium Salt","Aleviatin, Diphenylhydantoin sodium, Eptoin, Phenytoin soluble, Prompt,Phenytek,Dilantin sodium, Diphantoine","[Na+].[O-]C1=NC(=O)C(N1)(C2=CC=CC=C2)C3=CC=CC=C3",2.084,2,1,2]
["S2525","Phenytoin","c11","L3900-10","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.",252.27,"57-41-0",{"v":50,"d":"50.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Phenytoin-Lepitoin.html","C15H12N2O2","Free Base","Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722","O=C1NC(=O)C(N1)(C2=CC=CC=C2)C3=CC=CC=C3",2.105,2,2,2]
["S2528","Ciclopirox","d11","L3900-10","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator.",207.27,"29342-05-0",{"v":42,"d":"42.00"},202.63,"<1","N/A","http://selleckchem.com/products/Ciclopirox-Penlac.html","C12H17NO2","Free Base","HOE 296b, Penlac","CC1=CC(=O)N(O)C(=C1)C2CCCCC2",2.489,1,0,1]
["S2529","Dopamine HCl","e11","L3900-10","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Dopamine HCl(ASL279, NSC 173182) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.",189.64,"62-31-7",{"v":38,"d":"38.00"},200.38,{"v":38,"d":"38.00"},200.38,"http://selleckchem.com/products/Dopamine-hydrochloride-Inotropin.html","C8H11NO2.HCl","Hydrochloride","ASL279, NSC 173182","Cl.NCCC1=CC(=C(O)C=C1)O",1.155,0,3,2]
["S2533","Ritodrine HCl","f11","L3900-10","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.",323.81,"23239-51-2",{"v":65,"d":"65.00"},200.73,{"v":65,"d":"65.00"},200.73,"http://selleckchem.com/products/Ritodrine-hydrochloride-Yutopar.html","C17H21NO3.HCl","Hydrochloride","NSC 291565,DU 21220, Ritodrine","Cl.CC(NCCC1=CC=C(O)C=C1)C(O)C2=CC=C(O)C=C2",3.037,0,4,6]
["S2535","Econazole nitrate","g11","L3900-10","in 10mM DMSO","Calcium Channel,Fungal","Transmembrane Transporters","Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.",{"v":444.7,"d":"444.70"},"24169-02-6",{"v":89,"d":"89.00"},200.13,"<1","N/A","http://selleckchem.com/products/Econazole-nitrate-Spectazole.html","C18H15Cl3N2O.HNO3","Nitrate","NSC 243115,Spectazole","O[N+]([O-])=O.ClC1=CC=C(COC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C=C1",3.722,2,0,6]
["S2536","Miconazole","h11","L3900-10","in 10mM DMSO","Fungal","Microbiology","Miconazole (Monistat,R18134) is an imidazole antifungal agent.",416.13,"22916-47-8",{"v":83,"d":"83.00"},199.46,"<1","N/A","http://selleckchem.com/products/Miconazole-Monistat.html","C18H14Cl4N2O","Free Base","Monistat,R18134","ClC1=CC=C(COC(C[N]2C=CN=C2)C3=C(Cl)C=C(Cl)C=C3)C(=C1)Cl",5.645,2,0,6]
["S2537","Secnidazole","a2","L3900-11","in 10mM DMSO","Anti-infection","Microbiology","Secnidazole (Flagentyl, PM 185184, RP 14539) is a nitroimidazole anti-infective.",185.18,"3366-95-8",{"v":37,"d":"37.00"},199.81,{"v":37,"d":"37.00"},199.81,"http://selleckchem.com/products/Secnidazole-Flagentyl.html","C7H11N3O3","free base","PM 185184, RP 14539","CC(O)C[N]1C(=NC=C1[N+]([O-])=O)C",{"v":0.04,"d":"0.040"},1,1,3]
["S2541","Clomipramine HCl","b2","L3900-11","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Clomipramine HCl(Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.",351.31,"17321-77-6",{"v":70,"d":"70.00"},199.25,{"v":70,"d":"70.00"},199.25,"http://selleckchem.com/products/Clomipramine-hydrochloride-Anafranil.html","C19H23ClN2.HCl","Hydrochloride","Anafranil","Cl.CN(C)CCCN1C2=C(CCC3=C1C=C(Cl)C=C3)C=CC=C2",5.434,0,0,4]
["S2547","Tiotropium Bromide hydrate","c2","L3900-11","in 10mM DMSO","AChR","Neuronal Signaling","Tiotropium Bromide hydrate (BA 679BR) is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.",490.43,"139404-48-1",{"v":8,"d":"8.00"},16.31,"<1","N/A","http://selleckchem.com/products/Tiotropium-Bromide-hydrate.html","C19H22NO4S2.Br.xH2O","quaternary-N bromide salt&hydr","BA 679BR","O.[Br-].C[N+]1(C)C2CC(CC1C3OC23)OC(=O)C(O)(C4=CC=CS4)C5=CC=CS5",-1.727,3,0,5]
["S2549","Trospium chloride","d2","L3900-11","in 10mM DMSO","AChR","Neuronal Signaling","Trospium chloride  is a competitive muscarinic cholinergic receptor antagonist.",427.96,"10405-02-4",{"v":41,"d":"41.00"},{"v":95.8,"d":"95.80"},{"v":86,"d":"86.00"},200.95,"http://selleckchem.com/products/Trospium-chloride-Sanctura.html","C25H30NO3.Cl","quaternary-N chloride salt","N/A","[Cl-].OC(C(=O)OC1CC2CCC(C1)[N+]23CCCC3)(C4=CC=CC=C4)C5=CC=CC=C5",-0.324,2,0,5]
["S2551","Sulbactam sodium","e2","L3900-11","in 10mM DMSO","β-lactamase","Microbiology","Sulbactam sodium (Unasyn, CP-45899-2) is an irreversible β-lactamase inhibitor.",255.22,"69388-84-7",{"v":3,"d":"3.00"},11.75,{"v":51,"d":"51.00"},199.83,"http://selleckchem.com/products/sulbactam-sodium-unasyn.html","C8H10NO5S.Na","Sodium  salt","Unasyn, CP-45899-2","[Na+].CC1(C)C(N2C(CC2=O)[S]1(=O)=O)C([O-])=O",-2.145,3,0,1]
["S2552","Azelastine HCl","f2","L3900-11","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.",418.36,"79307-93-0",{"v":28,"d":"28.00"},66.93,{"v":35,"d":"35.00"},83.66,"http://selleckchem.com/products/azelastine.html","C22H24ClN3O.HCl","Hydrochloride","N/A","Cl.CN1CCCC(CC1)N2N=C(CC3=CC=C(Cl)C=C3)C4=CC=CC=C4C2=O",4.476,2,0,3]
["S2553","5-Aminolevulinic acid HCl","g2","L3900-11","in 10mM DMSO","Others","Others","5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.",167.59,"5451-09-2",{"v":34,"d":"34.00"},202.88,{"v":34,"d":"34.00"},202.88,"http://selleckchem.com/products/5-Aminolevulinic-acid-hydrochloride.html","C5H9NO3.HCl","Hydrochloride","5-ALA hydrochloride","Cl.NCC(=O)CCC(O)=O",-3.318,2,1,4]
["S2555","Clarithromycin","h2","L3900-11","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.",747.95,"81103-11-9",{"v":25,"d":"25.00"},33.42,"<1","N/A","http://selleckchem.com/products/clarithromycin.html","C38H69NO13","free base","A-56268","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(CC(C)C(=O)C(C)C(O)C1(C)O)OC",{"v":2.2,"d":"2.200"},9,3,8]
["S2556","Rosiglitazone (BRL 49653)","a3","L3900-11","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",357.43,"122320-73-4",{"v":71,"d":"71.00"},198.64,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-Avandia.html","C18H19N3O3S","Free Base","BRL 49653","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",3.268,4,1,7]
["S2557","Terbinafine HCl","b3","L3900-11","in 10mM DMSO","Fungal","Microbiology","Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug.",327.89,"78628-80-5",{"v":66,"d":"66.00"},201.29,"<1","N/A","http://selleckchem.com/products/Terbinafine-hydrochloride-Lamisil.html","C21H25N.HCl","Hydrochloride","KWD 201,KWD 2019,TDT 067 hydrochloride","Cl.CN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC2=C1C=CC=C2",5.717,0,0,6]
["S2559","Cortisone acetate","c3","L3900-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Cortisone acetate (Cortone, NSC 49420) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.",402.48,"50-04-4",{"v":7,"d":"7.00"},17.39,"<1","N/A","http://selleckchem.com/products/Cortisone-acetate-Cortone.html","C23H30O6","free base","Cortone,NSC 49420","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(=O)CC12C",1.619,5,0,4]
["S2561","Clomifene citrate","d3","L3900-11","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Clomifene citrate (NSC 35770, Clomiphene citrate) is a selective estrogen receptor modulator, used in the treatment of ovulation induction.",598.08,"50-41-9",{"v":120,"d":"120.00"},200.64,"<1","N/A","http://selleckchem.com/products/Clomifene-citrate-Serophene.html","C26H28ClNO.C6H8O7","Citrate","NSC 35770, Clomiphene citrate","CCN(CC)CCOC1=CC=C(C=C1)C(=C(Cl)/C2=CC=CC=C2)/C3=CC=CC=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",2.129,4,0,14]
["S2564","Cloxacillin Sodium","e3","L3900-11","in 10mM DMSO","Anti-infection","Microbiology","Cloxacillin Sodium(Cloxacap,BRL 1621 sodium salt) is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin.",475.88,"7081-44-9",{"v":55,"d":"55.00"},115.58,{"v":55,"d":"55.00"},115.58,"http://selleckchem.com/products/Cloxacillin-sodium-Cloxacap.html","C19H19ClN3NaO6S","Sodium Salt & hydrate","Cloxacap,BRL 1621 sodium salt","O.[Na+].CC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C([O-])=O)C(=NO1)C4=CC=CC=C4Cl",0.619,4,1,4]
["S2565","Amoxicillin Sodium","f3","L3900-11","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin Sodium (Clavulanate,Amoxycillin sodium) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.",387.39,"34642-77-8",{"v":78,"d":"78.00"},201.35,{"v":78,"d":"78.00"},201.35,"http://selleckchem.com/products/amoxicillin-amox.html","C16H18N3O5S.Na","Sodium Salt","Clavulanate,Amoxycillin sodium","[Na+].CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C([O-])=O",-1.534,2,3,4]
["S2566","Isoprenaline (NCI-C55630) HCl","g3","L3900-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.",247.72,"51-30-9",{"v":50,"d":"50.00"},201.84,{"v":50,"d":"50.00"},201.84,"http://selleckchem.com/products/Isoprenaline-hydrochloride.html","C11H17NO3.HCl","Hydrochloride","NCI-c55630,Isoproterenol hydrochloride","Cl.CC(C)NCC(O)C1=CC=C(O)C(=C1)O",1.481,0,4,4]
["S2567","Medroxyprogesterone acetate (NSC-26386)","h3","L3900-11","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Medroxyprogesterone acetate (MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.",386.52,"71-58-9",{"v":12,"d":"12.00"},31.05,"<1","N/A","http://selleckchem.com/products/Medroxyprogesterone-acetate.html","C24H34O4","Free Base","MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin","CC1CC2C(CCC3(C)C2CCC3(OC(C)=O)C(C)=O)C4(C)CCC(=O)C=C14",3.755,4,0,3]
["S2569","Phenylephrine (NCI-C55641) HCl","a4","L3900-11","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Phenylephrine HCl (NCI-c55641,Phenylephrine hydrochloride,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride) is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.",203.67,"61-76-7",{"v":41,"d":"41.00"},201.31,{"v":41,"d":"41.00"},201.31,"http://selleckchem.com/products/Phenylephrine-hydrochloride.html","C9H13NO2.HCl","Hydrochloride","NCI-c55641,Phenylephrine hydrochloride,(R)-(-)-Phenylephrine hydrochloride, L-Phenylephrine hydrochloride","Cl.CNCC(O)C1=CC(=CC=C1)O",0.997,0,3,3]
["S2570","Prednisolone Acetate","b4","L3900-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.",402.48,"52-21-1",{"v":81,"d":"81.00"},201.25,"<1","N/A","http://selleckchem.com/products/Prednisolone-acetate-Omnipred.html","C23H30O6","free base","Omnipred,Prednisolone-21-acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C",1.639,4,1,4]
["S2573","Tetracaine HCl","c4","L3900-11","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Tetracaine HCl (Amethocaine hydrochloride) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.",300.82,"136-47-0",{"v":60,"d":"60.00"},199.45,{"v":60,"d":"60.00"},199.45,"http://selleckchem.com/products/tetracaine-hydrochloride-pontocaine.html","C15H24N2O2.HCl","Hydrochloride","Amethocaine hydrochloride","Cl.CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C",3.343,2,1,9]
["S2574","Tetracycline HCl","d4","L3900-11","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Tetracycline HCl (NCI-c55561) is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic.",{"v":480.9,"d":"480.90"},"64-75-5",{"v":96,"d":"96.00"},199.63,{"v":96,"d":"96.00"},199.63,"http://selleckchem.com/products/tetracycline-hydrochloride.html","C22H24N2O8.HCl","Hydrochloride","NCI-c55561","Cl.CN(C)C1C2CC3C(=C(O)C2(O)C(=O)C(=C1O)C(N)=O)C(=O)C4=C(O)C=CC=C4C3(C)O",-0.513,3,4,2]
["S2576","Xylometazoline HCl","e4","L3900-11","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.",280.84,"1218-35-5",{"v":27,"d":"27.00"},96.14,{"v":56,"d":"56.00"},{"v":199.4,"d":"199.40"},"http://selleckchem.com/products/xylometazoline-hcl.html","C16H24N2.HCl","HCl","N/A","Cl.CC1=C(CC2=NCCN2)C(=CC(=C1)C(C)(C)C)C",3.906,1,1,3]
["S2579","Zidovudine","f4","L3900-11","in 10mM DMSO","CRISPR/Cas9,Reverse Transcriptase","Microbiology","Zidovudine (ZDV, Azidothymidine, NSC 602670,Retrovir) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.",267.24,"30516-87-1",{"v":53,"d":"53.00"},198.32,{"v":53,"d":"53.00"},198.32,"http://selleckchem.com/products/zidovudine-retrovir.html","C10H13N5O4","free base","Azidothymidine, NSC 602670,Retrovir","CC1=CN(C2CC(N=[N+]=[N-])C(CO)O2)C(=O)NC1=O",0.064,4,2,3]
["S2581","Quinapril HCl","g4","L3900-11","in 10mM DMSO","RAAS","Endocrinology & Hormones","Quinapril HCl (CI-906, PD-109452-2) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.",474.98,"82586-55-8",{"v":18,"d":"18.00"},{"v":37.9,"d":"37.90"},{"v":95,"d":"95.00"},200.01,"http://selleckchem.com/products/quinapril-hydrochloride-accupril.html","C25H30N2O5.HCl","Hydrochloride","CI-906, PD-109452-2","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=C(CC2C(O)=O)C=CC=C3",1.038,4,1,10]
["S2583","Thiamphenicol","h4","L3900-11","in 10mM DMSO","Antibiotics","Microbiology","Thiamphenicol (Thiophenicol,Dextrosulphenidol) is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol.",356.22,"15318-45-3",{"v":71,"d":"71.00"},199.32,"<1","N/A","http://selleckchem.com/products/thiamphenicol-thiophenicol.html","C12H15Cl2NO5S","free base","Thiophenicol,Dextrosulphenidol","C[S](=O)(=O)C1=CC=C(C=C1)C(O)C(CO)NC(=O)C(Cl)Cl",0.657,3,3,6]
["S2584","Clobetasol propionate","a5","L3900-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.",466.97,"25122-46-7",{"v":93,"d":"93.00"},199.16,"<1","N/A","http://selleckchem.com/products/clobetasol-propionate.html","C25H32ClFO5","free base","CGP9555, CCl 4725","CCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.958,4,1,5]
["S2585","Brompheniramine hydrogen maleate","b5","L3900-11","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Brompheniramine hydrogen maleate(Brompheniramine maleate) is a histamine H1 receptors antagonist.",435.31,"980-71-2",{"v":87,"d":"87.00"},199.86,{"v":46,"d":"46.00"},105.67,"http://selleckchem.com/products/brompheniramine.html","C16H19BrN2.C4H4","Maleate","Brompheniramine maleate","CN(C)CCC(C1=CC=C(Br)C=C1)C2=CC=CC=N2.OC(=O)\\C=C/C(O)=O",0.784,3,0,7]
["S2586","Dimethyl Fumarate","c5","L3900-11","in 10mM DMSO","Nrf2","Immunology & Inflammation","Dimethyl fumarate (DMF,Tecfidera,BG-12) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.",144.13,"624-49-7",{"v":29,"d":"29.00"},201.21,"<1","N/A","http://selleckchem.com/products/dimethyl-Fumarate.html","C6H8O4","free base","DMF,Tecfidera,BG-12","COC(=O)\\C=C\\C(=O)OC",{"v":0.49,"d":"0.490"},4,0,4]
["S2589","Miglitol","d5","L3900-11","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Miglitol (BAY-M-1099,Glyset) is an oral anti-diabetic drug.",207.22,"72432-03-2",{"v":3,"d":"3.00"},14.48,"<1","N/A","http://selleckchem.com/products/miglitol-glyset.html","C8H17NO5","free base","BAY-M-1099,Glyset","OCCN1CC(O)C(O)C(O)C1CO",-2.444,0,5,3]
["S2590","Pioglitazone (AD-4833)","e5","L3900-11","in 10mM DMSO","PPAR","Metabolism","Pioglitazone (AD-4833, U 72107) is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ.",356.44,"111025-46-8",{"v":10,"d":"10.00"},28.06,"<1","N/A","https://www.selleckchem.com/products/pioglitazone.html","C19H20N2O3S","Free Base","U 72107","CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",3.907,4,1,7]
["S2593","Tolvaptan","f5","L3900-11","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Tolvaptan (OPC-41061) is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM, used to treat hyponatremia.",448.94,"150683-30-0",{"v":89,"d":"89.00"},198.24,"<1","N/A","http://selleckchem.com/products/tolvaptan-opc-41061.html","C26H25ClN2O3","free base","OPC-41061","CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(O)C4=C3C=CC(=C4)Cl)C",5.127,2,2,3]
["S2594","Pramiracetam","g5","L3900-11","in 10mM DMSO","Others","Others","Pramiracetam (CI-879,Pramistar) is a more potent nootropic drug derived from piracetam.",269.38,"68497-62-1",{"v":54,"d":"54.00"},200.46,"<1","N/A","http://selleckchem.com/products/pramiracetam.html","C14H27N3O2","free base","CI-879,Pramistar","CC(C)N(CCNC(=O)CN1CCCC1=O)C(C)C",0.486,2,1,7]
["S2596","Clindamycin palmitate HCl","h5","L3900-11","in 10mM DMSO","Bacterial","Microbiology","Clindamycin palmitate HCl is a water soluble hydrochloride salt of the ester of clindamycin and palmitic acid and a lincosamide antibiotic.",699.85,"25507-04-4",{"v":140,"d":"140.00"},200.04,{"v":140,"d":"140.00"},200.04,"http://selleckchem.com/products/clindamycin-palmitate-hcl.html","C34H63ClN2O6S.HCl","Hydrochloride","N/A","Cl.CCCCCCCCCCCCCCCC(=O)OC1C(O)C(O)C(OC1SC)C(NC(=O)C2CC(CCC)CN2C)C(C)Cl",8.635,4,3,23]
["S2599","L-Thyroxine","a6","L3900-11","in 10mM DMSO","THR","Metabolism","L-Thyroxine (NSC 36397,Levothyroxine) is a synthetic form of thyroxine and a hormone replacement drug.",776.87,"51-48-9",{"v":100,"d":"100.00"},128.72,"<1","N/A","http://selleckchem.com/products/l-thyroxine.html","C15H11I4NO4","free base","NSC 36397,Levothyroxine","NC(CC1=CC(=C(OC2=CC(=C(O)C(=C2)I)I)C(=C1)I)I)C(O)=O",2.026,2,2,5]
["S2601","Gliclazide","b6","L3900-11","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Gliclazide(S1702, SE1702)  is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.",323.41,"21187-98-4",{"v":65,"d":"65.00"},200.98,"<1","N/A","http://selleckchem.com/products/gliclazide-diamicron.html","C15H21N3O3S","free base","S1702, SE1702","CC1=CC=C(C=C1)[S](=O)(=O)NC(=O)NN2CC3CCCC3C2",1.905,3,2,3]
["S2602","Acemetacin","c6","L3900-11","in 10mM DMSO","COX","Neuronal Signaling","Acemetacin (K-708,TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.",415.82,"53164-05-9",{"v":83,"d":"83.00"},199.61,"<1","N/A","http://selleckchem.com/products/acemetacin-emflex.html","C21H18ClNO6","free base","K-708,TVX 1322","COC1=CC2=C(C=C1)[N](C(=C2CC(=O)OCC(O)=O)C)C(=O)C3=CC=C(Cl)C=C3",3.942,5,0,7]
["S2605","Idebenone","d6","L3900-11","in 10mM DMSO","ROS","Immunology & Inflammation","Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.",338.44,"58186-27-9",{"v":68,"d":"68.00"},200.92,"<1","N/A","http://selleckchem.com/products/idebenone.html","C19H30O5","free base","CV-2619","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCCO",3.836,4,1,12]
["S2606","Mifepristone (RU486)","e6","L3900-11","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.",429.59,"84371-65-3",{"v":85,"d":"85.00"},197.86,"<1","N/A","http://selleckchem.com/products/Mifepristone(Mifeprex).html","C29H35NO2","free base","RU486, C-1073, RU 38486, RU-486, Mifegyne","CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)C5=CC=C(C=C5)N(C)C",5.655,1,0,3]
["S2608","Fluocinonide","f6","L3900-11","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluocinonide (Vanos,nsc 101791) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.",494.52,"356-12-7",{"v":99,"d":"99.00"},200.19,"<1","N/A","http://selleckchem.com/products/Fluocinonide(Vanos).html","C26H32F2O7","free base","Vanos,nsc 101791","CC(=O)OCC(=O)C12OC(C)(C)OC1CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC23C",1.374,6,1,4]
["S2609","Inulin","g6","L3900-11","in 10mM DMSO","Others","Others","Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.","N/A","9005-80-5",{"v":10,"d":"10.00"},{"v":10,"d":"10.00"},{"v":104,"d":"104.00"},"N/A","http://selleckchem.com/products/inulin.html","C6nH10n+2O5n+1","Free Base","N/A","OCC1OC(OC2(CO)OC(CO)C(O)C2O)C(O)C(O)C1O",-3.577,3,8,5]
["S2610","Lonidamine (AF-1890)","h6","L3900-11","in 10mM DMSO","Carbohydrate Metabolism,Others","Metabolism","Lonidamine (AF 1890, Diclondazolic Acid, DICA) is an orally administered small molecule hexokinase inactivator.",321.16,"50264-69-2",{"v":64,"d":"64.00"},199.28,"<1","N/A","http://selleckchem.com/products/lonidamine.html","C15H10Cl2N2O2","free base","Diclondazolic Acid, DICA","OC(=O)C1=N[N](CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C13",{"v":4.65,"d":"4.650"},2,0,3]
["S2612","Ribitol","a7","L3900-11","in 10mM DMSO","Anti-infection","Microbiology","Ribitol (Adonitol) is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.",152.15,"488-81-3",{"v":30,"d":"30.00"},197.17,{"v":30,"d":"30.00"},197.17,"http://selleckchem.com/products/ribitol-adonitol.html","C5H12O5","free base","Adonitol","OCC(O)C(O)C(O)CO",{"v":-2.43,"d":"-2.430"},0,5,4]
["S2614","Arecoline HBr","b7","L3900-11","in 10mM DMSO","AChR","Neuronal Signaling","Arecoline(NSC-31750) is a muscarinic acetylcholine receptor agonist.",236.11,"300-08-3",{"v":47,"d":"47.00"},199.06,{"v":47,"d":"47.00"},199.06,"https://www.selleckchem.com/products/arecoline-hbr.html","C8H13NO2.HBr","HBr","NSC-31750","Br.COC(=O)C1=CCCN(C)C1",1.234,2,0,2]
["S2615","Noradrenaline bitartrate monohydrate","c7","L3900-11","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.",337.28,"108341-18-0",{"v":64,"d":"64.00"},189.75,{"v":64,"d":"64.00"},189.75,"http://selleckchem.com/products/noradrenaline-bitartrate-monohydrate-levophed.html","C8H11NO3.C4H6O6.H2O","bitartrate monohydrate","Levophed","O.NCC(O)C1=CC(=C(O)C=C1)O.OC(C(O)C(O)=O)C(O)=O",-4.409,2,6,5]
["S2617","TAK-733","d7","L3900-11","in 10mM DMSO","MEK","MAPK","TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.",504.23,"1035555-63-5",{"v":101,"d":"101.00"},200.31,"<1","N/A","http://selleckchem.com/products/tak-733.html","C17H15F2IN4O4","free base","N/A","CN1C(=O)C(=C(NC2=CC=C(I)C=C2F)C3=C1N=CN(CC(O)CO)C3=O)F",0.383,3,3,5]
["S2619","MG132","e7","L3900-11","in 10mM DMSO","Proteasome","Proteases","MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor.  MG132 also inhibits calpain (IC50=1.2 μM).",475.62,"1211877-36-9",{"v":90,"d":"90.00"},189.23,"<1","N/A","http://selleckchem.com/products/MG132.html","C26H41N3O5","free base","(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al","CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",4.371,5,3,15]
["S2621","AZD5438","f7","L3900-11","in 10mM DMSO","CDK","Cell Cycle","AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β.",371.46,"602306-29-6",{"v":74,"d":"74.00"},199.21,"<1","N/A","http://selleckchem.com/products/AZD5438.html","C18H21N5O2S","free base","N/A","CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)[S](C)(=O)=O)C",2.966,5,1,5]
["S2623","Omecamtiv mecarbil (CK-1827452)","g7","L3900-11","in 10mM DMSO","ATPase","Transmembrane Transporters","Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.",401.43,"873697-71-3",{"v":80,"d":"80.00"},199.29,"<1","N/A","http://selleckchem.com/products/Omecamtiv-mecarbil-CK-1827452.html","C20H24FN5O3","free base","N/A","COC(=O)N1CCN(CC1)CC2=CC=CC(=C2F)NC(=O)NC3=CN=C(C)C=C3",1.794,4,2,5]
["S2624","OSI-027","h7","L3900-11","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1","N/A","http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2625","Fostamatinib (R788)","a8","L3900-11","in 10mM DMSO","Syk","Angiogenesis","Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.",580.46,"901119-35-5",{"v":116,"d":"116.00"},199.84,"<1","N/A","http://selleckchem.com/products/R7935788-Fostamatinib.html","C23H26FN6O9P","free base","N/A","COC1=C(OC)C(=CC(=C1)NC2=NC=C(F)C(=N2)NC3=CC=C4OC(C)(C)C(=O)N(CO[P](O)(O)=O)C4=N3)OC",3.458,9,2,10]
["S2626","Rabusertib (LY2603618)","b8","L3900-11","in 10mM DMSO","Apoptosis related,Autophagy,Chk","Cell Cycle","Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.",{"v":436.3,"d":"436.30"},"911222-45-2",{"v":13,"d":"13.00"},{"v":29.8,"d":"29.80"},"<1","N/A","http://selleckchem.com/products/LY2603618-IC-83.html","C18H22BrN5O3","free base","IC-83","CC1=NC=C(NC(=O)NC2=C(OCC3CNCCO3)C=C(C)C(=C2)Br)N=C1",{"v":1.58,"d":"1.580"},5,3,5]
["S2629","PNU-120596","c8","L3900-11","in 10mM DMSO","AChR","Neuronal Signaling","PNU-120596 (Nsc 216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.",311.72,"501925-31-1",{"v":62,"d":"62.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/pnu120596.html","C13H14ClN3O4","free base","Nsc 216666","COC1=CC(=C(NC(=O)NC2=NOC(=C2)C)C=C1Cl)OC",2.293,5,2,4]
["S2630","GW3965 HCl","d8","L3900-11","in 10mM DMSO","Liver X Receptor","Metabolism","GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively.",618.51,"405911-17-3",{"v":16,"d":"16.00"},25.87,"<1","N/A","http://selleckchem.com/products/gw3965.html","C33H31ClF3NO3.HCl","hydrochloride","N/A","Cl.OC(=O)CC1=CC=CC(=C1)OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F",5.473,2,0,14]
["S2631","URB597","e8","L3900-11","in 10mM DMSO","FAAH","Metabolism","URB597 (KDS-4103) is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.",{"v":338.4,"d":"338.40"},"546141-08-6",{"v":68,"d":"68.00"},200.95,"<1","N/A","http://selleckchem.com/products/urb597.html","C20H22N2O3","free base","KDS-4103","NC(=O)C1=CC(=CC=C1)C2=CC=CC(=C2)OC(=O)NC3CCCCC3",3.972,3,2,5]
["S2632","BMS-378806","f8","L3900-11","in 10mM DMSO","CD markers,gp120/CD4","Immunology & Inflammation","BMS-378806 (BMS 806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.",406.43,"357263-13-9",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/bms806.html","C22H22N4O4","free base","BMS 806","COC1=C2C(=NC=C2C(=O)C(=O)N3CCN(CC3C)C(=O)C4=CC=CC=C4)[NH]C=C1",1.714,5,1,4]
["S2633","NPS-2143","g8","L3900-11","in 10mM DMSO","CaSR","GPCR & G Protein","NPS-2143 (SB262470) is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM.",408.92,"284035-33-2",{"v":82,"d":"82.00"},200.53,"<1","N/A","http://selleckchem.com/products/nps-2143.html","C24H25ClN2O2","free base","SB262470","CC(C)(CC1=CC=C2C=CC=CC2=C1)NCC(O)COC3=C(C#N)C(=CC=C3)Cl",4.844,1,2,8]
["S2634","Rebastinib (DCC-2036)","h8","L3900-11","in 10mM DMSO","Bcr-Abl","Angiogenesis","Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.",553.59,"1020172-07-9",{"v":111,"d":"111.00"},200.51,"<1","N/A","http://selleckchem.com/products/dcc-2036.html","C30H28FN7O3","free base","N/A","CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(NC(=O)NC3=CC(=N[N]3C4=CC5=C(C=C4)N=CC=C5)C(C)(C)C)C=C2)F",{"v":5.14,"d":"5.140"},6,3,7]
["S2635","CCT128930","a9","L3900-11","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.",341.84,"885499-61-6",{"v":68,"d":"68.00"},198.92,"<1","N/A","http://selleckchem.com/products/cct128930.html","C18H20ClN5","free base","N/A","NC1(CCN(CC1)C2=C3C=C[NH]C3=NC=N2)CC4=CC=C(Cl)C=C4",2.813,2,2,3]
["S2637","Fasiglifam(TAK-875) Hemihydrate","b9","L3900-11","in 10mM DMSO","GPR","Endocrinology & Hormones","Fasiglifam(TAK-875) Hemihydrate is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.",533.63,"1374598-80-7",{"v":100,"d":"100.00"},{"v":187.4,"d":"187.40"},"<1","N/A","http://selleckchem.com/products/tak-875.html","C29H32O7S.1/2H2O","Hemihydrate","N/A","O.CC1=CC(=CC(=C1C2=CC=CC(=C2)COC3=CC=C4C(COC4=C3)CC(O)=O)C)OCCC[S](C)(=O)=O.CC5=CC(=CC(=C5C6=CC=CC(=C6)COC7=CC=C8C(COC8=C7)CC(O)=O)C)OCCC[S](C)(=O)=O",9.968,12,0,22]
["S2639","SNX-2112 (PF-04928473)","c9","L3900-11","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.",464.48,"908112-43-6",{"v":93,"d":"93.00"},200.22,"<1","N/A","http://selleckchem.com/products/snx-2112.html","C23H27F3N4O3","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC(=C(C=C3)C(N)=O)NC4CCC(O)CC4",3.709,3,3,5]
["S2656","PF-04929113 (SNX-5422)","d9","L3900-11","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.",521.53,"908115-27-5",{"v":104,"d":"104.00"},199.41,"<1","N/A","http://selleckchem.com/products/pf-04929113.html","C25H30F3N5O4","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC=C(C(N)=O)C(=C3)NC4CCC(CC4)OC(=O)CN",3.126,5,3,8]
["S2658","Omipalisib (GSK2126458)","e9","L3900-11","in 10mM DMSO","Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.",{"v":505.5,"d":"505.50"},"1086062-66-9",{"v":100,"d":"100.00"},197.82,"<1","N/A","http://selleckchem.com/products/gsk2126458.html","C25H17F2N5O3S","free base","GSK458","COC1=NC=C(C=C1N[S](=O)(=O)C2=CC=C(F)C=C2F)C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3",3.705,7,1,6]
["S2660","MK-0752","f9","L3900-11","in 10mM DMSO","Beta Amyloid,Secretase","Proteases","MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.",{"v":442.9,"d":"442.90"},"471905-41-6",{"v":89,"d":"89.00"},200.95,"<1","N/A","http://selleckchem.com/products/mk-0752.html","C21H21ClF2O4S","free base","N/A","OC(=O)CCC1CCC(CC1)(C2=C(F)C=CC(=C2)F)[S](=O)(=O)C3=CC=C(Cl)C=C3",5.615,3,0,6]
["S2661","WYE-125132 (WYE-132)","g9","L3900-11","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.",{"v":519.6,"d":"519.60"},"1144068-46-1",{"v":104,"d":"104.00"},200.15,"<1","N/A","http://selleckchem.com/products/wye-125132.html","C27H33N7O4","free base","N/A","CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7",2.093,7,2,4]
["S2662","Foscenvivint (ICG-001)","h9","L3900-11","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Wnt/beta-catenin","Stem Cells & Wnt","Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.",548.63,"780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry)",{"v":100,"d":"100.00"},182.27,"<1","N/A","http://selleckchem.com/products/icg-001.html","C33H32N4O4","free base","N/A","OC1=CC=C(CC2N3C(CN(CC4=CC=CC5=C4C=CC=C5)C2=O)N(CCC3=O)C(=O)NCC6=CC=CC=C6)C=C1",4.065,3,2,6]
["S2663","WAY-100635 Maleate","a10","L3900-11","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.",538.64,"1092679-51-0",{"v":85,"d":"85.00"},{"v":157.8,"d":"157.80"},"<1","N/A","http://selleckchem.com/products/way-100635.html","C25H34N4O2.C4H4O4","Maleate","N/A","COC1=C(C=CC=C1)N2CCN(CC2)CCN(C(=O)C3CCCCC3)C4=NC=CC=C4.OC(=O)\\C=C/C(O)=O",1.427,5,0,9]
["S2665","Ciprofibrate","b10","L3900-11","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","Ciprofibrate (Win-35833) is a peroxisome proliferator-activated receptor agonist.",289.15,"52214-84-3",{"v":58,"d":"58.00"},200.59,"<1","N/A","http://selleckchem.com/products/ciprofibrate.html","C13H14Cl2O3","free base","Win-35833","CC(C)(OC1=CC=C(C=C1)C2CC2(Cl)Cl)C(O)=O",2.954,2,0,4]
["S2667","Dolutegravir (GSK1349572)","c10","L3900-11","in 10mM DMSO","Integrase","Microbiology","Dolutegravir (GSK1349572,S/GSK1349572,Tivicay) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.",419.38,"1051375-16-6",{"v":83,"d":"83.00"},197.91,"<1","N/A","http://selleckchem.com/products/s-gsk1349572.html","C20H19F2N3O5","free base","GSK1349572,S/GSK1349572,Tivicay","CC1CCOC2CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(=C3C(=O)N12)O",{"v":0.3,"d":"0.300"},4,2,3]
["S2672","PF-00562271 Besylate","d10","L3900-11","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-00562271 Besylate (PF-562271) is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.",665.66,"939791-38-5",{"v":14,"d":"14.00"},21.03,"<1","N/A","http://selleckchem.com/products/pf-00562271.html","C21H20F3N7O3S.C6H6O3S","Benzenesulfonic","PF-562271 Besylate","CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O.O[S](=O)(=O)C5=CC=CC=C5",3.653,6,3,9]
["S2673","Trametinib (GSK1120212)","e10","L3900-11","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.",615.39,"871700-17-3",{"v":22,"d":"22.00"},35.75,"<1","N/A","http://selleckchem.com/products/gsk1120212-jtp-74057.html","C26H23FIN5O4","free base","JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(=CC=C5)NC(C)=O)C",3.176,4,2,5]
["S2679","Flavopiridol (L86-8275) HCl","f10","L3900-11","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.",{"v":438.3,"d":"438.30"},"131740-09-5",{"v":88,"d":"88.00"},200.78,"<1","N/A","http://selleckchem.com/products/flavopiridol-hydrochloride.html","C21H20ClNO5.HCl","Hydrochloride","NSC 649890, Alvocidib, HMR-1275, DSP-2033","Cl.CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,2]
["S2680","Ibrutinib (PCI-32765)","g10","L3900-11","in 10mM DMSO","BTK,Target Protein Ligand","Angiogenesis","Ibrutinib (PCI-32765,Imbruvica) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.",{"v":440.5,"d":"440.50"},"936563-96-1",{"v":88,"d":"88.00"},199.77,"<1","N/A","http://selleckchem.com/products/pci-32765.html","C25H24N6O2","free base","PCI-32765,Imbruvica","NC1=C2C(=NC=N1)[N](N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)C5CCCN(C5)C(=O)C=C",3.985,5,1,5]
["S2683","CHIR-124","h10","L3900-11","in 10mM DMSO","Chk","Cell Cycle","CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.",419.91,"405168-58-3",{"v":7,"d":"7.00"},16.67,"<1","N/A","http://selleckchem.com/products/chir-124.html","C23H22ClN5O","free base","N/A","ClC1=CC2=C(NC(=O)C(=C2NC3CN4CCC3CC4)C5=NC6=C([NH]5)C=CC=C6)C=C1",3.089,2,3,3]
["S2685","KW-2478","a11","L3900-11","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.",574.66,"819812-04-9",{"v":115,"d":"115.00"},200.12,"<1","N/A","http://selleckchem.com/products/kw-2478.html","C30H42N2O9","free base","N/A","CCC1=C(CC(=O)N(CCOC)CCOC)C(=C(O)C=C1O)C(=O)C2=CC=C(OCCN3CCOCC3)C(=C2)OC",2.673,7,2,16]
["S2687","Mardepodect (PF-2545920)","b11","L3900-11","in 10mM DMSO","PDE","Metabolism","Mardepodect (PF-2545920) is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.",392.45,"1292799-56-4",{"v":78,"d":"78.00"},198.75,"<1","N/A","http://selleckchem.com/products/pf-2545920.html","C25H20N4O","free base","N/A","C[N]1C=C(C2=CC=NC=C2)C(=N1)C3=CC=C(OCC4=NC5=CC=CC=C5C=C4)C=C3",4.763,4,0,5]
["S2688","R547","c11","L3900-11","in 10mM DMSO","CDK","Cell Cycle","R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.",441.45,"741713-40-6",{"v":60,"d":"60.00"},135.92,"<1","N/A","http://selleckchem.com/products/r547.html","C18H21F2N5O4S","free base","Ro 4584820","COC1=CC=C(F)C(=C1C(=O)C2=C(N)N=C(NC3CCN(CC3)[S](C)(=O)=O)N=C2)F",1.133,6,2,6]
["S2690","ADX-47273","d11","L3900-11","in 10mM DMSO","GluR","Neuronal Signaling","ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.",369.36,"851881-60-2",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/adx-47273.html","C20H17F2N3O2","free base","BA 94673139","FC1=CC=C(C=C1)C(=O)N2CCCC(C2)C3=NC(=NO3)C4=CC=C(F)C=C4",3.577,4,0,3]
["S2691","BMY 7378 Dihydrochloride","e11","L3900-11","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor","Neuronal Signaling","BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.",458.42,"21102-95-4",{"v":92,"d":"92.00"},200.69,{"v":92,"d":"92.00"},200.69,"http://selleckchem.com/products/bmy-7378.html","C22H31N3O3.2HCl","Dihydrochloride","N/A","Cl.Cl.COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O",3.384,3,0,5]
["S2692","TG101209","f11","L3900-11","in 10mM DMSO","c-RET,FLT3,JAK","JAK/STAT","TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.",509.67,"936091-14-4",{"v":102,"d":"102.00"},200.13,"<1","N/A","http://selleckchem.com/products/tg101209.html","C26H35N7O2S","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(C)C(=N3)NC4=CC(=CC=C4)[S](=O)(=O)NC(C)(C)C)C=C2",4.659,4,3,8]
["S2693","Resminostat","g11","L3900-11","in 10mM DMSO","HDAC","Epigenetics","Resminostat (RAS2410) dose-dependently and selectively inhibits HDAC1/3/6 with IC50 of 42.5 nM/50.1 nM/71.8 nM, less potent to HDAC8 with IC50 of 877 nM.",{"v":349.4,"d":"349.40"},"864814-88-0",{"v":70,"d":"70.00"},200.34,"<1","N/A","http://selleckchem.com/products/resminostat-ras2410.html","C16H19N3O4S","free base","RAS2410","CN(C)CC1=CC=C(C=C1)[S](=O)(=O)[N]2C=CC(=C2)\\C=C\\C(=O)NO",1.837,3,1,6]
["S2694","Turofexorate Isopropyl (XL335)","h11","L3900-11","in 10mM DMSO","FXR","Metabolism","Turofexorate Isopropyl (XL335, Fxr 450) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.",438.47,"629664-81-9",{"v":33,"d":"33.00"},75.26,"<1","N/A","http://selleckchem.com/products/way-362450.html","C25H24F2N2O3","free base","Fxr 450","CC(C)OC(=O)C1=CN(CC(C)(C)C2=C1[NH]C3=CC=CC=C23)C(=O)C4=CC=C(F)C(=C4)F",4.968,3,1,4]
["S2695","Nepicastat (SYN-117) HCl","a2","L3900-12","in 10mM DMSO","Hydroxylase","Metabolism","Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.",331.81,"170151-24-3",{"v":66,"d":"66.00"},198.91,"<1","N/A","http://selleckchem.com/products/nepicastat-hydrochloride.html","C14H15F2N3S.HCl","Hydrochloride","N/A","Cl.NCC1=CNC(=S)N1C2CCC3=C(F)C=C(F)C=C3C2",3.008,0,2,2]
["S2696","Apitolisib (GDC-0980)","b2","L3900-12","in 10mM DMSO","Apoptosis related,Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.",{"v":498.6,"d":"498.60"},"1032754-93-0",{"v":20,"d":"20.00"},40.11,"<1","N/A","http://selleckchem.com/products/GDC-0980-RG7422.html","C23H30N8O3S","free base","RG7422, GNE 390","CC(O)C(=O)N1CCN(CC1)CC2=C(C)C3=NC(=NC(=C3S2)N4CCOCC4)C5=CN=C(N)N=C5",1.013,6,2,5]
["S2698","RS-127445","c2","L3900-12","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","RS-127445 (MT500) is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.",281.33,"199864-87-4",{"v":56,"d":"56.00"},199.05,"<1","N/A","http://selleckchem.com/products/rs-127445.html","C17H16FN3","free base","MT500","CC(C)C1=NC(=NC(=C1)C2=C3C=CC=CC3=C(F)C=C2)N",4.298,2,1,2]
["S2699","CH5132799","d2","L3900-12","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CH5132799 (MEN1611, PA799) inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.",377.42,"1007207-67-1",{"v":12,"d":"12.00"},31.79,"<1","N/A","http://selleckchem.com/products/ch5132799.html","C15H19N7O3S","free base","MEN1611, PA799","C[S](=O)(=O)N1CCC2=C(N=C(N=C12)N3CCOCC3)C4=CN=C(N)N=C4",0.095,7,1,3]
["S2700","Tirbanibulin","e2","L3900-12","in 10mM DMSO","Src","Angiogenesis","Tirbanibulin(KX2-391,KX 01), the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Phase 2.",431.53,"897016-82-9",{"v":86,"d":"86.00"},199.29,"<1","N/A","http://selleckchem.com/products/kx2-391.html","C26H29N3O3","free base","KX2-391,KX 01","O=C(CC1=CC=C(C=N1)C2=CC=C(OCCN3CCOCC3)C=C2)NCC4=CC=CC=C4",3.262,4,1,9]
["S2703","GSK1838705A","f2","L3900-12","in 10mM DMSO","ALK,IGF-1R","Protein Tyrosine Kinase","GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.",532.57,"1116235-97-2",{"v":107,"d":"107.00"},200.91,"<1","N/A","http://selleckchem.com/products/gsk1838705a.html","C27H29FN8O3","free base","N/A","CNC(=O)C1=C(F)C=CC=C1NC2=C3C=C[NH]C3=NC(=N2)NC4=C(OC)C=C5CCN(C(=O)CN(C)C)C5=C4",3.508,5,4,8]
["S2713","Geldanamycin (NSC 122750)","g2","L3900-12","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Antiviral,Autophagy,HSP (HSP90)","Cytoskeletal Signaling","Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.",560.64,"30562-34-6",{"v":36,"d":"36.00"},64.21,"<1","N/A","http://selleckchem.com/products/geldanamycin.html","C29H40N2O9","free base","NSC 122750","COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)\\C(=C\\C=C\\C(OC)C(OC(N)=O)\\C(=C\\C(C)C1O)C)C)C2=O",{"v":2.36,"d":"2.360"},8,3,5]
["S2717","CP-91149","h2","L3900-12","in 10mM DMSO","Phosphorylase","Metabolism","CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.",399.87,"186392-40-5",{"v":80,"d":"80.00"},200.07,"<1","N/A","http://selleckchem.com/products/cp-91149.html","C21H22ClN3O3","free base","N/A","CN(C)C(=O)C(O)C(CC1=CC=CC=C1)NC(=O)C2=CC3=CC(=CC=C3[NH]2)Cl",3.082,2,3,6]
["S2718","TAK-901","a3","L3900-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.",504.64,"934541-31-8",{"v":101,"d":"101.00"},200.14,"<1","N/A","http://selleckchem.com/products/tak-901.html","C28H32N4O3S","free base","N/A","CC[S](=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C)C3=C2C4=C([NH]3)N=CC(=C4)C)C(=O)NC5CCN(C)CC5",4.056,4,2,5]
["S2719","AMG-900","b3","L3900-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.",503.58,"945595-80-2",{"v":100,"d":"100.00"},198.58,"<1","N/A","http://selleckchem.com/products/amg-900.html","C28H21N7OS","free base","N/A","CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=C(C=CC=N4)C5=NC(=NC=C5)N)C=C3)C6=C2C=CC=C6",6.487,6,2,6]
["S2721","Nilvadipine","c3","L3900-12","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nilvadipine (ARC029, FR34235,FK235) is a potent calcium channel blocker with an IC50 of 0.03 nM.",385.37,"75530-68-6",{"v":77,"d":"77.00"},199.81,"<1","N/A","http://selleckchem.com/products/nilvadipine-arc029.html","C19H19N3O6","free base","ARC029, FR34235,FK235","COC(=O)C1=C(NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C)C#N",2.087,4,1,7]
["S2722","JTC-801","d3","L3900-12","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.",447.96,"244218-51-7",{"v":90,"d":"90.00"},200.91,"<1","N/A","http://selleckchem.com/products/jtc-801.html","C26H25N3O2.HCl","Hydrochloride","N/A","Cl.CCC1=CC=C(OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C)C=C4N)C=C1",5.228,3,2,6]
["S2726","PH-797804","e3","L3900-12","in 10mM DMSO","p38 MAPK","MAPK","PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.",{"v":477.3,"d":"477.30"},"586379-66-0",{"v":96,"d":"96.00"},201.13,"<1","N/A","http://selleckchem.com/products/ph-797804.html","C22H19BrF2N2O3","free base","N/A","CNC(=O)C1=CC(=C(C)C=C1)N2C(=CC(=C(Br)C2=O)OCC3=CC=C(F)C=C3F)C",3.801,3,1,5]
["S2727","Dacomitinib (PF-00299804)","f3","L3900-12","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Dacomitinib (PF299804, PF299) is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.",469.94,"1110813-31-4",{"v":19,"d":"19.00"},40.43,"<1","N/A","http://selleckchem.com/products/pf299804.html","C24H25ClFN5O2","free base","PF299804,PF299","COC1=C(NC(=O)/C=C/CN2CCCCC2)C=C3C(=NC=NC3=C1)NC4=CC(=C(F)C=C4)Cl",5.055,4,2,7]
["S2728","AG-1478 (Tyrphostin AG-1478)","g3","L3900-12","in 10mM DMSO","EGFR,HCV,PI4K","Protein Tyrosine Kinase","AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).",315.75,"153436-53-4,175178-82-2",{"v":25,"d":"25.00"},79.18,"<1","N/A","http://selleckchem.com/products/ag-1478-tyrphostin-ag-1478.html","C16H14ClN3O2","free base","NSC 693255","COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)Cl",4.109,4,1,4]
["S2730","Crenolanib (CP-868596)","h3","L3900-12","in 10mM DMSO","FLT3,Mitophagy,PDGFR","Protein Tyrosine Kinase","Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.",443.54,"670220-88-9",{"v":88,"d":"88.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/crenolanib-cp-868596.html","C26H29N5O2","free base","ARO 002","CC1(COC1)COC2=CC3=C(C=C2)[N](C=N3)C4=NC5=C(C=CC=C5C=C4)N6CCC(N)CC6",3.192,4,1,5]
["S2736","Fedratinib (TG101348)","a4","L3900-12","in 10mM DMSO","Apoptosis related,c-RET,FLT3,JAK","JAK/STAT","Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.",524.68,"936091-26-8",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/Fedratinib-SAR302503-TG101348.html","C27H36N6O3S","free base","SAR302503","CC1=C(NC2=CC=CC(=C2)[S](=O)(=O)NC(C)(C)C)N=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=C1",5.123,5,3,11]
["S2738","PAC-1","b4","L3900-12","in 10mM DMSO","Caspase","Apoptosis","PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.",392.49,"315183-21-2",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/pac-1.html","C23H28N4O2","free base","N/A","OC1=C(CC=C)C=CC=C1/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3",3.331,2,2,8]
["S2740","GSK1070916","c4","L3900-12","in 10mM DMSO","Aurora Kinase","Cell Cycle","GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.",507.63,"942918-07-2",{"v":93,"d":"93.00"},{"v":183.2,"d":"183.20"},"<1","N/A","http://selleckchem.com/products/gsk1070916.html","C30H33N7O","free base","N/A","CC[N]1C=C(C2=C3C=C([NH]C3=NC=C2)C4=CC=CC(=C4)CN(C)C)C(=N1)C5=CC=C(NC(=O)N(C)C)C=C5",4.841,3,2,7]
["S2741","Niraparib (MK-4827)","d4","L3900-12","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.",320.39,"1038915-60-4",{"v":64,"d":"64.00"},199.76,"<1","N/A","http://selleckchem.com/products/mk-4827.html","C19H20N4O","Free Base","N/A","NC(=O)C1=CC=CC2=C[N](N=C12)C3=CC=C(C=C3)C4CCCNC4",2.618,2,2,3]
["S2742","PHA-767491 HCl","e4","L3900-12","in 10mM DMSO","CDK","Cell Cycle","PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.",{"v":249.7,"d":"249.70"},"942425-68-5",{"v":24,"d":"24.00"},96.12,"<1","N/A","http://selleckchem.com/products/pha-767491.html","C12H11N3O.HCl","HCl","CAY10572, NMS 1116354","O=C1NCCC2=C1C=C([NH]2)C3=CC=NC=C3",1.252,2,2,1]
["S2743","PF-04691502","f4","L3900-12","in 10mM DMSO","Akt,Apoptosis related,mTOR,PI3K","PI3K/Akt/mTOR","PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.",425.48,"1013101-36-4",{"v":14,"d":"14.00"},{"v":32.9,"d":"32.90"},"<1","N/A","http://selleckchem.com/products/pf-04691502.html","C22H27N5O4","free base","PF4691502","COC1=CC=C(C=N1)C2=CC3=C(C)N=C(N)N=C3N(C4CCC(CC4)OCCO)C2=O",1.616,6,2,6]
["S2747","AMG-458","g4","L3900-12","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.",539.58,"913376-83-7",{"v":21,"d":"21.00"},38.92,"<1","N/A","http://selleckchem.com/products/amg458.html","C30H29N5O5","free base","N/A","COC1=CC2=NC=CC(=C2C=C1)OC3=CN=C(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)C5=CC=CC=C5)C=C3",3.125,6,1,8]
["S2748","Anacetrapib (MK-0859)","h4","L3900-12","in 10mM DMSO","CETP,LDL","Metabolism","Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.",637.51,"875446-37-0",{"v":127,"d":"127.00"},199.21,"<1","N/A","http://selleckchem.com/products/anacetrapib-mk-0859.html","C30H25F10NO3","free base","N/A","COC1=CC(=C(C=C1C2=CC=C(C=C2CN3C(C)C(OC3=O)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C(F)(F)F)C(C)C)F",9.343,3,0,9]
["S2749","BGT226 (NVP-BGT226) maleate","a5","L3900-12","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.",{"v":650.6,"d":"650.60"},"1245537-68-1",{"v":30,"d":"30.00"},46.11,"<1","N/A","http://selleckchem.com/products/nvp-bgt226.html","C28H25F3N6O2.C4H4O","maleate","N/A","COC1=NC=C(C=C1)C2=CC=C3N=CC4=C(N(C(=O)N4C)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F)C3=C2.OC(=O)\\C=C/C(O)=O",1.618,6,1,7]
["S2751","Milciclib (PHA-848125)","b5","L3900-12","in 10mM DMSO","Autophagy,CDK","Cell Cycle","Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.",460.57,"802539-81-7",{"v":92,"d":"92.00"},199.75,"<1","N/A","http://selleckchem.com/products/pha-848125.html","C25H32N8O","free base","N/A","CNC(=O)C1=N[N](C)C2=C1C(C)(C)CC3=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N=C23",3.825,4,2,4]
["S2752","HER2-Inhibitor-1","c5","L3900-12","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","HER2-Inhibitor-1 is an analog of ARRY-380. ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.",569.63,"937265-83-3",{"v":100,"d":"100.00"},175.55,"<1","N/A","http://selleckchem.com/products/her2-inhibitor-1.html","C29H27N7O4S","free base","N/A","CC1=CC(=CC=C1OC2=CC3=NC=N[N]3C=C2)NC4=C5C=C(C=CC5=NC=N4)C6=CC=C(CNCC[S](C)(=O)=O)O6",4.446,8,2,10]
["S2753","Tivantinib (ARQ 197)","d5","L3900-12","in 10mM DMSO","Apoptosis related,c-Met","Protein Tyrosine Kinase","Tivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.",369.42,"905854-02-6",{"v":73,"d":"73.00"},197.61,"<1","N/A","http://selleckchem.com/products/arq-197.html","C23H19N3O2","free base","N/A","O=C1NC(=O)C(C1C2=C[NH]C3=C2C=CC=C3)C4=C[N]5CCCC6=CC=CC4=C56",{"v":3.52,"d":"3.520"},2,2,2]
["S2754","Xevinapant (AT406)","e5","L3900-12","in 10mM DMSO","E3 Ligase ,IAP","Apoptosis","Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.",561.71,"1071992-99-8",{"v":100,"d":"100.00"},178.03,"<1","N/A","http://selleckchem.com/products/at-406.html","C32H43N5O4","free base","ARRY-334543, Debio1143, SM-406","CNC(C)C(=O)NC1CN(CCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C",2.264,4,3,9]
["S2755","Varlitinib","f5","L3900-12","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Varlitinib (ARRY334543) is a selective and potent ErbB1(EGFR) and ErbB2(HER2) inhibitor with IC50 of 7 nM and 2 nM, respectively. Phase 2.",466.94,"845272-21-1",{"v":6,"d":"6.00"},12.85,"<1","N/A","http://selleckchem.com/products/arry334543.html","C22H19ClN6O2S","free base","ARRY334543","CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(OCC5=NC=CS5)C=C4)Cl",4.577,6,2,7]
["S2757","Evofosfamide (TH-302)","g5","L3900-12","in 10mM DMSO","Others","Others","Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.",449.04,"918633-87-1",{"v":90,"d":"90.00"},200.43,{"v":10,"d":"10.00"},22.27,"http://selleckchem.com/products/th-302.html","C9H16Br2N5O4P","free base","Evofosfamide","C[N]1C(=CN=C1[N+]([O-])=O)CO[P](=O)(NCCBr)NCCBr",0.537,3,2,10]
["S2759","Fimepinostat (CUDC-907)","h5","L3900-12","in 10mM DMSO","Apoptosis related,HDAC,PI3K","Cytoskeletal Signaling","CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1.",508.55,"1339928-25-4",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/pi3k-hdac-inhibitor-i.html","C23H24N8O4S","free base","N/A","COC1=CC=C(C=N1)C2=NC3=C(SC(=C3)CN(C)C4=NC=C(C=N4)C(=O)NO)C(=N2)N5CCOCC5",2.303,8,1,7]
["S2760","Canagliflozin (JNJ 28431754)","a6","L3900-12","in 10mM DMSO","SGLT","GPCR & G Protein","Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.",444.52,"842133-18-0",{"v":88,"d":"88.00"},197.97,"<1","N/A","http://selleckchem.com/products/canagliflozin.html","C24H25FO5S","free base","TA 7284","CC1=C(CC2=CC=C(S2)C3=CC=C(F)C=C3)C=C(C=C1)C4OC(CO)C(O)C(O)C4O",3.446,1,4,5]
["S2762","Alectinib (CH5424802)","b6","L3900-12","in 10mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (CH5424802, AF-802, RG-7853) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.",482.62,"1256580-46-7",{"v":6,"d":"6.00"},12.43,{"v":1,"d":"1.00"},2.07,"http://www.selleckchem.com/products/ch5424802.html","C30H34N4O2","Free Base","AF-802, RG-7853,CH5424802","CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C)(C)C5=C(C2=O)C6=CC=C(C=C6[NH]5)C#N",5.203,2,1,3]
["S2765","MK-2048","c6","L3900-12","in 10mM DMSO","Integrase","Microbiology","MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.",461.87,"869901-69-9",{"v":9,"d":"9.00"},19.49,"<1","N/A","http://selleckchem.com/products/mk-2048.html","C21H21ClFN5O4","free base","N/A","CCN1CC(C)[N]2C(=C(O)C3=C2C(=NN(CC4=CC=C(F)C(=C4)Cl)C3=O)C(=O)NC)C1=O",2.446,4,2,4]
["S2768","Dinaciclib (SCH727965)","d6","L3900-12","in 10mM DMSO","Caspase,CDK","Cell Cycle","Dinaciclib (SCH727965, PS-095760) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.",396.49,"779353-01-4",{"v":26,"d":"26.00"},65.58,"<1","N/A","http://selleckchem.com/products/dinaciclib-sch727965.html","C21H28N6O2","free base","PS-095760","CCC1=C2N=C(C=C(NCC3=CC=C[N+](=C3)[O-])[N]2N=C1)N4CCCCC4CCO",2.152,2,2,7]
["S2769","Dovitinib (TKI-258) Dilactic Acid","e6","L3900-12","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.",572.59,"852433-84-2",{"v":90,"d":"90.00"},157.18,{"v":70,"d":"70.00"},122.25,"http://selleckchem.com/products/dovitinib.html","C27H33FN6O7","Dilactic Acid","N/A","CC(O)C(O)=O.CC(O)C(O)=O.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(NC4=O)C=CC=C5F",-2.038,4,5,4]
["S2770","MK-5108 (VX-689)","f6","L3900-12","in 10mM DMSO","Aurora Kinase,Autophagy","Cell Cycle","MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.",461.94,"1010085-13-8",{"v":92,"d":"92.00"},199.16,"<1","N/A","http://selleckchem.com/products/mk-5108-vx-689.html","C22H21ClFN3O3S","free base","N/A","OC(=O)C1(CCC(CC1)OC2=C(F)C(=CC=C2)Cl)CC3=CC=CC(=N3)NC4=NC=CS4",5.574,4,1,7]
["S2772","Dalcetrapib (JTT-705)","g6","L3900-12","in 10mM DMSO","CETP","Metabolism","Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3.",389.59,"211513-37-0",{"v":78,"d":"78.00"},200.21,"<1","N/A","http://selleckchem.com/products/dalcetrapib-jtt-705.html","C23H35NO2S","free base","RO4607381","CCC(CC)CC1(CCCCC1)C(=O)NC2=C(SC(=O)C(C)C)C=CC=C2",7.025,2,1,9]
["S2773","SB705498","h6","L3900-12","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.",429.23,"501951-42-4",{"v":86,"d":"86.00"},200.36,"<1","N/A","http://selleckchem.com/products/sb705498.html","C17H16BrF3N4O","free base","N/A","FC(F)(F)C1=CN=C(C=C1)N2CCC(C2)NC(=O)NC3=CC=CC=C3Br",3.745,2,2,4]
["S2774","MK-2461","a7","L3900-12","in 10mM DMSO","c-Met,FGFR,PDGFR,RON","Protein Tyrosine Kinase","MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.",495.55,"917879-39-1",{"v":99,"d":"99.00"},199.78,"<1","N/A","http://selleckchem.com/products/mk-2461.html","C24H25N5O5S","free base","N/A","CN(CC1COCCO1)[S](=O)(=O)NC2=CC3=C(C=C2)C=CC4=C(C=C(C=N4)C5=C[N](C)N=C5)C3=O",0.924,7,1,6]
["S2776","Devimistat (CPI-613)","b7","L3900-12","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells. Phase 2.",388.59,"95809-78-2",{"v":77,"d":"77.00"},198.15,"<1","N/A","http://selleckchem.com/products/cpi-613.html","C22H28O2S2","free base","N/A","OC(=O)CCCCC(CCSCC1=CC=CC=C1)SCC2=CC=CC=C2",{"v":5.63,"d":"5.630"},1,0,13]
["S2778","GW842166X","c7","L3900-12","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.",449.25,"666260-75-9",{"v":20,"d":"20.00"},44.52,"<1","N/A","http://selleckchem.com/products/gw-842166x.html","C18H17Cl2F3N4O2","free base","N/A","FC(F)(F)C1=NC(=NC=C1C(=O)NCC2CCOCC2)NC3=CC=C(Cl)C=C3Cl",4.449,4,2,6]
["S2781","RITA (NSC 652287)","d7","L3900-12","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2783","Vistusertib (AZD2014)","e7","L3900-12","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.",462.54,"1009298-59-2",{"v":38,"d":"38.00"},82.16,"<1","N/A","http://selleckchem.com/products/azd2014.html","C25H30N6O3","free base","N/A","CNC(=O)C1=CC=CC(=C1)C2=CC=C3C(=N2)N=C(N=C3N4CCOCC4C)N5CCOCC5C",3.103,6,1,4]
["S2784","TAK-285","f7","L3900-12","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.",547.96,"871026-44-7",{"v":110,"d":"110.00"},200.74,"<1","N/A","http://selleckchem.com/products/tak-285.html","C26H25ClF3N5O3","free base","N/A","CC(C)(O)CC(=O)NCC[N]1C=CC2=C1C(=NC=N2)NC3=CC=C(OC4=CC=CC(=C4)C(F)(F)F)C(=C3)Cl",5.586,4,2,10]
["S2785","A-803467","g7","L3900-12","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.",357.79,"944261-79-4",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/a-803467.html","C19H16ClNO4","free base","N/A","COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(Cl)C=C3)OC",4.451,4,1,5]
["S2787","Laquinimod","h7","L3900-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.",{"v":356.8,"d":"356.80"},"248281-84-7",{"v":61,"d":"61.00"},170.96,"<1","N/A","http://selleckchem.com/products/laquinimod-abr-215062.html","C19H17ClN2O3","free base","ABR-215062, LAQ","CCN(C(=O)C1=C(O)C2=C(C=CC=C2Cl)N(C)C1=O)C3=CC=CC=C3",2.884,2,1,3]
["S2789","Tofacitinib (CP-690550)","a8","L3900-12","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.",312.37,"477600-75-2",{"v":62,"d":"62.00"},198.48,"<1","N/A","http://selleckchem.com/products/tofacitinib-cp-690550.html","C16H20N6O","free base","Tasocitinib","CC1CCN(CC1N(C)C2=C3C=C[NH]C3=NC=N2)C(=O)CC#N",1.512,3,1,3]
["S2790","Istradefylline","b8","L3900-12","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM. Phase 3.",384.43,"155270-99-8",{"v":6,"d":"6.00"},15.61,"<1","N/A","http://selleckchem.com/products/istradefylline-kw-6002.html","C20H24N4O4","free base","KW-6002","CCN1C(=O)N(CC)C2=C([N](C)C(=N2)\\C=C\\C3=CC=C(OC)C(=C3)OC)C1=O",2.957,5,0,6]
["S2791","Sotrastaurin (AEB071)","c8","L3900-12","in 10mM DMSO","PKC","TGF-beta/Smad","Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.",438.48,"425637-18-9",{"v":87,"d":"87.00"},198.41,"<1","N/A","http://selleckchem.com/products/sotrastaurin-aeb071.html","C25H22N6O2","free base","AEB071","CN1CCN(CC1)C2=NC(=C3C=CC=CC3=N2)C4=C(C(=O)NC4=O)C5=C[NH]C6=C5C=CC=C6",3.483,4,2,3]
["S2792","Torcetrapib","d8","L3900-12","in 10mM DMSO","CETP","Metabolism","Torcetrapib (CP-529414) is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. Phase 3.",600.47,"262352-17-0",{"v":120,"d":"120.00"},199.84,"<1","N/A","http://selleckchem.com/products/torcetrapib-cp-529414.html","C26H25F9N2O4","free base","CP-529414","CCOC(=O)N1C(CC)CC(N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C(=O)OC)C3=C1C=CC(=C3)C(F)(F)F",7.345,4,0,10]
["S2794","Sofosbuvir (GS-7977)","e8","L3900-12","in 10mM DMSO","DNA/RNA Synthesis,HCV Protease","DNA Damage/DNA Repair","Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.",529.45,"1190307-88-0",{"v":100,"d":"100.00"},188.88,{"v":11,"d":"11.00"},20.78,"http://selleckchem.com/products/psi-7977-gs-7977.html","C22H29FN3O9P","free base","PSI-7977","CC(C)OC(=O)C(C)N[P](=O)(OCC1OC(N2C=CC(=O)NC2=O)C(C)(F)C1O)OC3=CC=CC=C3",0.921,7,3,11]
["S2796","WP1066","f8","L3900-12","in 10mM DMSO","Apoptosis related,JAK,STAT","JAK/STAT","WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.",356.22,"857064-38-1",{"v":71,"d":"71.00"},199.32,"<1","N/A","http://selleckchem.com/products/wp1066.html","C17H14BrN3O","free base","N/A","CC(NC(=O)\\C(=C\\C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",3.566,2,1,4]
["S2797","Lonafarnib (SCH66336)","g8","L3900-12","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2799","Daporinad","h8","L3900-12","in 10mM DMSO","Autophagy,NAMPT,Transferase","Metabolism","Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.",391.51,"658084-64-1",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://www.selleck.cn/products/apo866-fk866.html","C24H29N3O2","Free Base","FK866, APO866","O=C(NCCCCC1CCN(CC1)C(=O)C2=CC=CC=C2)/C=C/C3=CC=CN=C3",3.269,3,1,8]
["S2801","AZD4547","a9","L3900-12","in 10mM DMSO","FGFR","Angiogenesis","AZD4547 (ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.",463.57,"1035270-39-3",{"v":92,"d":"92.00"},198.46,"<1","N/A","http://selleckchem.com/products/azd4547.html","C26H33N5O3","free base","ABSK 091","COC1=CC(=CC(=C1)OC)CCC2=CC(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CC(C)NC(C)C4",4.204,4,3,8]
["S2803","Galeterone","b9","L3900-12","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Endocrinology & Hormones","Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.",388.55,"851983-85-2",{"v":24,"d":"24.00"},61.77,"<1","N/A","http://selleckchem.com/products/galeterone-tok-001.html","C26H32N2O","free base","TOK-001","CC12CCC(O)CC1=CCC3C2CCC4(C)C3CC=C4[N]5C=NC6=C5C=CC=C6",4.897,1,1,1]
["S2807","Dabrafenib (GSK2118436)","c9","L3900-12","in 10mM DMSO","Raf","MAPK","Dabrafenib (GSK2118436, GSK2118436A) is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.",519.56,"1195765-45-7",{"v":30,"d":"30.00"},57.74,"<1","N/A","http://selleckchem.com/products/dabrafenib-gsk2118436.html","C23H20F3N5O2S2","free base","GSK2118436A","CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F",5.377,5,2,6]
["S2808","Ipatasertib (GDC-0068)","d9","L3900-12","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Ipatasertib (GDC-0068, RG7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.",{"v":458,"d":"458.00"},"1001264-89-6",{"v":92,"d":"92.00"},200.87,"<1","N/A","http://selleckchem.com/products/gdc-0068.html","C24H32ClN5O2","free base","RG7440","CC(C)NCC(C(=O)N1CCN(CC1)C2=C3C(C)CC(O)C3=NC=N2)C4=CC=C(Cl)C=C4",3.102,3,2,6]
["S2809","MPEP","e9","L3900-12","in 10mM DMSO","GluR","Neuronal Signaling","MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.",193.24,"96206-92-7",{"v":39,"d":"39.00"},201.82,"<1","N/A","http://selleckchem.com/products/mpep.html","C14H11N","free base","N/A","CC1=NC(=CC=C1)C#CC2=CC=CC=C2",3.499,1,0,2]
["S2811","Sapanisertib (MLN0128)","f9","L3900-12","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.",309.33,"1224844-38-5",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://selleckchem.com/products/ink128.html","C15H15N7O","free base","INK 128,TAK-228","CC(C)[N]1N=C(C2=CC3=C(OC(=N3)N)C=C2)C4=C(N)N=CN=C14",1.886,5,2,2]
["S2812","(R)-(-)-Gossypol acetic acid","g9","L3900-12","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2","Apoptosis","(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.",578.61,"866541-93-7",{"v":116,"d":"116.00"},200.48,"<1","N/A","https://www.selleckchem.com/products/at101-acetic-acid.html","C30H30O8.C2H4O2","free base","AT-101 acetic acid, (-)-Gossypol acetic acid, (R)-Gossypol acetic acid","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(C)C=C4C(=C(O)C(=C(C=O)C4=C3O)O)C(C)C)O.CC(O)=O",6.388,3,6,5]
["S2813","Ciproxifan Maleate","h9","L3900-12","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ciproxifan (FUB 359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.",{"v":386.4,"d":"386.40"},"184025-19-2",{"v":54,"d":"54.00"},139.75,{"v":1,"d":"1.00"},2.59,"http://selleckchem.com/products/ciproxifan.html","C16H18N2O2.C4H4O4","Maleate","FUB 359","OC(=O)\\C=C/C(O)=O.O=C(C1CC1)C2=CC=C(OCCCC3=C[NH]C=N3)C=C2",2.605,5,1,9]
["S2814","Alpelisib (BYL719)","a10","L3900-12","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.",441.47,"1217486-61-7",{"v":88,"d":"88.00"},199.33,"<1","N/A","http://selleckchem.com/products/byl719.html","C19H22F3N5O2S","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CC(=NC=C3)C(C)(C)C(F)(F)F",2.826,4,2,5]
["S2818","Tacedinaline (CI994)","b10","L3900-12","in 10mM DMSO","HDAC","Epigenetics","Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.",{"v":269.3,"d":"269.30"},"112522-64-2",{"v":54,"d":"54.00"},200.52,"<1","N/A","http://selleckchem.com/products/ci994-tacedinaline.html","C15H15N3O2","free base","PD-123654, GOE-5549, Acetyldinaline","CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N)C=CC=C2",0.988,2,3,3]
["S2820","TAE226 (NVP-TAE226)","c10","L3900-12","in 10mM DMSO","Apoptosis related,FAK,Pyk2","Angiogenesis","TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.",468.94,"761437-28-9",{"v":94,"d":"94.00"},200.45,"<1","N/A","http://selleckchem.com/products/nvp-tae226.html","C23H25ClN6O3","free base","N/A","CNC(=O)C1=C(NC2=C(Cl)C=NC(=N2)NC3=C(OC)C=C(C=C3)N4CCOCC4)C=CC=C1",3.917,5,3,7]
["S2822","OC000459","d10","L3900-12","in 10mM DMSO","GPR","Endocrinology & Hormones","OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM. Phase 2.",348.37,"851723-84-7, 950688-14-9 (sodium salt)",{"v":4,"d":"4.00"},11.48,"<1","N/A","http://selleckchem.com/products/oc000459.html","C21H17FN2O2","free base","N/A","CC1=C(CC2=CC=C3C=CC=CC3=N2)C4=CC(=CC=C4[N]1CC(O)=O)F",4.329,2,0,4]
["S2823","Tideglusib (NP031112)","e10","L3900-12","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.",334.39,"865854-05-3",{"v":8,"d":"8.00"},23.92,"<1","N/A","http://selleckchem.com/products/tideglusib.html","C19H14N2O2S","free base","NP-12","O=C1SN(C(=O)N1CC2=CC=CC=C2)C3=C4C=CC=CC4=CC=C3",{"v":4.63,"d":"4.630"},2,0,3]
["S2828","JNJ-1661010","f10","L3900-12","in 10mM DMSO","FAAH","Metabolism","JNJ-1661010 (Takeda-25) is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2.",365.45,"681136-29-8",{"v":36,"d":"36.00"},98.51,"<1","N/A","http://selleckchem.com/products/jnj-1661010.html","C19H19N5OS","Free Base","Takeda-25","O=C(NC1=CC=CC=C1)N2CCN(CC2)C3=NC(=NS3)C4=CC=CC=C4",3.271,3,1,3]
["S2830","Clindamycin","g10","L3900-12","in 10mM DMSO","Bacterial","Microbiology","Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.",424.98,"18323-44-9",{"v":85,"d":"85.00"},200.01,"<1","N/A","http://selleckchem.com/products/clindamycin.html","C18H33ClN2O5S","Free Base","N/A","CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O)C(O)C2O",1.277,2,4,7]
["S2840","Apalutamide (ARN-509)","h10","L3900-12","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.",477.43,"956104-40-8",{"v":18,"d":"18.00"},{"v":37.7,"d":"37.70"},"<1","N/A","http://selleckchem.com/products/arn-509.html","C21H15F4N5O2S","free base","N/A","CNC(=O)C1=CC=C(C=C1F)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C#N)C(=C4)C(F)(F)F",4.452,3,1,4]
["S2842","SAR131675","a11","L3900-12","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.",358.39,"1433953-83-3",{"v":30,"d":"30.00"},83.71,"<1","N/A","http://selleckchem.com/products/sar131675.html","C18H22N4O4","free base","N/A","CCN1C(=C(C(=O)NC)C(=O)C2=CC=C(N=C12)C#CC(C)(O)COC)N",0.769,4,2,6]
["S2845","Semaxanib (SU5416)","b11","L3900-12","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.",238.28,"204005-46-9",{"v":22,"d":"22.00"},92.33,"<1","N/A","http://selleckchem.com/products/semaxanib-su5416.html","C15H14N2O","free base","semaxinib","CC1=CC(=C([NH]1)/C=C/2C(=O)NC3=CC=CC=C23)C",2.747,1,2,1]
["S2849","SB269970 HCl","c11","L3900-12","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.",388.95,"261901-57-9",{"v":11,"d":"11.00"},28.28,"<1","N/A","http://selleckchem.com/products/sb-269970-hcl.html","C18H28N2O3S.HCl","Hydrochloride","N/A","Cl.CC1CCN(CC1)CCC2CCCN2[S](=O)(=O)C3=CC=CC(=C3)O",2.946,2,1,5]
["S2851","Baricitinib (INCB028050)","d11","L3900-12","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.",371.42,"1187594-09-7",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/baricitinib-ly3009104.html","C16H17N7O2S","free base","LY3009104","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":0.36,"d":"0.360"},5,1,5]
["S2853","Carfilzomib (PR-171)","e11","L3900-12","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,Proteasome","Proteases","Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.",719.91,"868540-17-4",{"v":50,"d":"50.00"},69.45,"<1","N/A","http://selleckchem.com/products/carfilzomib-pr-171.html","C40H57N5O7","free base","N/A","CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)C4(C)CO4",3.799,7,4,20]
["S2856","SB 271046 hydrochloride","f11","L3900-12","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB 271046 hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.",488.45,"209481-24-3",{"v":40,"d":"40.00"},81.89,"<1","N/A","http://selleckchem.com/products/sb-271046.html","C20H22ClN3O3S2.HCl","hydrochloride","N/A","COC1=CC=C(N[S](=O)(=O)C2=C(C)C3=CC(=CC=C3S2)Cl)C=C1N4CCNCC4",4.403,3,2,5]
["S2857","(-)-Dizocilpine (MK 801) Maleate","g11","L3900-12","in 10mM DMSO","NMDAR","Neuronal Signaling","(-)-Dizocilpine (MK 801, Dizocilpine, C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.",337.37,"121917-57-5",{"v":67,"d":"67.00"},{"v":198.6,"d":"198.60"},"<1","N/A","http://selleckchem.com/products/--mk-801-maleate.html","C16H15N.C4H4O4","maleate","C13737","CC12NC(CC3=C1C=CC=C3)C4=C2C=CC=C4.OC(=O)\\C=C/C(O)=O",0.376,2,1,2]
["S2858","StemRegenin 1 (SR1)","h11","L3900-12","in 10mM DMSO","AhR","Metabolism","StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.",429.54,"1227633-49-9",{"v":86,"d":"86.00"},200.21,"<1","N/A","http://selleckchem.com/products/stemRegenin-1.html","C24H23N5OS","free base","N/A","CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=CC=C(O)C=C3)C4=CSC5=CC=CC=C45",{"v":5.19,"d":"5.190"},3,2,6]
["S2859","Golvatinib (E7050)","a2","L3900-13","in 10mM DMSO","c-Met,VEGFR","Protein Tyrosine Kinase","Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2.",633.69,"928037-13-2",{"v":20,"d":"20.00"},31.56,"<1","N/A","http://selleckchem.com/products/golvatinib-e7050.html","C33H37F2N7O4","free base","N/A","CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4)F",3.173,5,3,8]
["S2864","IMD 0354","b2","L3900-13","in 10mM DMSO","IκB/IKK","NF-κB","IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.",383.67,"978-62-1",{"v":10,"d":"10.00"},26.06,"<1","N/A","http://selleckchem.com/products/imd-0354.html","C15H8ClF6NO2","free base","IKK2 Inhibitor V","OC1=C(C=C(Cl)C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F",4.921,1,2,4]
["S2866","U-104","c2","L3900-13","in 10mM DMSO","Carbonic Anhydrase","Metabolism","U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.",309.32,"178606-66-1",{"v":62,"d":"62.00"},200.44,"<1","N/A","http://selleckchem.com/products/u-104.html","C13H12FN3O3S","free base","MST-104, NSC 213841, SLC-0111, WBI-5111","N[S](=O)(=O)C1=CC=C(NC(=O)NC2=CC=C(F)C=C2)C=C1",1.433,3,3,3]
["S2867","WHI-P154","d2","L3900-13","in 10mM DMSO","EGFR,JAK","JAK/STAT","WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.",{"v":376.2,"d":"376.20"},"211555-04-3",{"v":75,"d":"75.00"},199.36,"<1","N/A","http://selleckchem.com/products/whi-p154.html","C16H14BrN3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC=C(O)C(=C3)Br",{"v":3.95,"d":"3.950"},4,2,4]
["S2868","Alogliptin (SYR-322) benzoate","e2","L3900-13","in 10mM DMSO","DPP","Proteases","Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.",461.51,"850649-62-6",{"v":68,"d":"68.00"},147.34,{"v":2,"d":"2.00"},4.33,"http://selleckchem.com/products/alogliptin-syr-322.html","C18H21N5O2.C7H6O2","benzoate","SYR-322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S2872","GW5074","f2","L3900-13","in 10mM DMSO","Apoptosis related,Raf","MAPK","GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted. GW5074 inhibits LK-induced apoptosis.",520.94,"220904-83-6",{"v":104,"d":"104.00"},199.64,"<1","N/A","http://selleckchem.com/products/gw5074.html","C15H8Br2INO2","free base","N/A","OC1=C(Br)C=C(C=C1Br)C=C2C(=O)NC3=CC=C(I)C=C23",4.564,1,2,1]
["S2874","Camostat Mesilate","g2","L3900-13","in 10mM DMSO","COVID-19,Sodium Channel","Transmembrane Transporters","Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.",494.52,"59721-29-8",{"v":99,"d":"99.00"},200.19,{"v":10,"d":"10.00"},20.22,"http://selleckchem.com/products/camostat-mesilate-foy-305.html","C20H22N4O5.CH4O3S","Mesilate","FOY-305, FOY-S980","CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1.C[S](O)(=O)=O",0.969,5,2,10]
["S2875","Prucalopride","h2","L3900-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Prucalopride (R-93877) is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.",367.87,"179474-81-8",{"v":60,"d":"60.00"},{"v":163.1,"d":"163.10"},"<1","N/A","http://selleckchem.com/products/prucalopride.html","C18H26ClN3O3","Free Base","R-93877","COCCCN1CCC(CC1)NC(=O)C2=CC(=C(N)C3=C2OCC3)Cl",1.056,3,2,6]
["S2876","(+)-Dizocilpine (MK 801) Maleate","a3","L3900-13","in 10mM DMSO","NMDAR","Neuronal Signaling","(+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.",337.37,"77086-22-7",{"v":68,"d":"68.00"},201.56,"<1","N/A","http://selleckchem.com/products/mk-801-maleate.html","C16H15N.C4H4O4","maleate","N/A","CC12NC(CC3=C1C=CC=C3)C4=C2C=CC=C4.OC(=O)\\C=C/C(O)=O",0.376,2,1,2]
["S2884","Acesulfame Potassium","b3","L3900-13","in 10mM DMSO","Others","Others","Acesulfame potassium is a non-nutritive sweetener.",202.25,"55589-62-3",{"v":40,"d":"40.00"},197.78,{"v":40,"d":"40.00"},197.78,"http://selleckchem.com/products/acesulfame-potassium.html","C4H5NO4S.K","Potassium Salt","N/A","[KH].CC1=CC(=O)N[S](=O)(=O)O1",-0.858,2,1,0]
["S2890","PF-562271","c3","L3900-13","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.",507.49,"717907-75-0",{"v":100,"d":"100.00"},197.05,"<1","N/A","http://selleckchem.com/products/pf-562271.html","C21H20F3N7O3S","free base","PF-00562271","CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O",2.491,6,3,8]
["S2894","SB742457","d3","L3900-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB742457 (GSK 742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.",353.44,"607742-69-8",{"v":78,"d":"78.00"},220.69,"<1","N/A","http://selleckchem.com/products/sb-742457.html","C19H19N3O2S","free base","GSK 742457","O=[S](=O)(C1=CC=CC=C1)C2=CC3=C(N=C2)C(=CC=C3)N4CCNCC4",2.702,3,1,3]
["S2900","Cobicistat (GS-9350)","e3","L3900-13","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.",776.02,"1004316-88-4",{"v":100,"d":"100.00"},128.86,"<1","N/A","http://selleckchem.com/products/cobicistat-gs-9350.html","C40H53N7O5S2","free base","N/A","CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5",4.765,7,3,20]
["S2902","S-Ruxolitinib (INCB018424)","f3","L3900-13","in 10mM DMSO","JAK","JAK/STAT","S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.",306.37,"941685-37-6",{"v":61,"d":"61.00"},199.11,{"v":5,"d":"5.00"},16.32,"http://selleckchem.com/products/s-ruxolitinib.html","C17H18N6","free base","N/A","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S2903","Lumiracoxib","g3","L3900-13","in 10mM DMSO","COX","Neuronal Signaling","Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of  0.06 μM. It also inhibits COX1 with Ki of 3 μM.",293.72,"220991-20-8",{"v":59,"d":"59.00"},200.87,"<1","N/A","http://selleckchem.com/products/lumiracoxib-cox-189.html","C15H13ClFNO2","free base","COX-189","CC1=CC=C(NC2=C(Cl)C=CC=C2F)C(=C1)CC(O)=O",{"v":4.4,"d":"4.400"},1,1,4]
["S2904","PF-477736","h3","L3900-13","in 10mM DMSO","Chk","Cell Cycle","PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.",419.48,"952021-60-2",{"v":6,"d":"6.00"},{"v":14.3,"d":"14.30"},"<1","N/A","http://selleckchem.com/products/pf-477736.html","C22H25N7O2","free base","PF-736, PF-00477736","C[N]1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(N)C5CCCCC5)[NH]2",2.089,4,4,4]
["S2905","JNJ-7777120","a4","L3900-13","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.",277.75,"459168-41-3",{"v":56,"d":"56.00"},201.62,"<1","N/A","http://selleckchem.com/products/jnj-7777120.html","C14H16ClN3O","free base","N/A","CN1CCN(CC1)C(=O)C2=CC3=CC(=CC=C3[NH]2)Cl",{"v":2.45,"d":"2.450"},1,1,1]
["S2906","Ki16198","b4","L3900-13","in 10mM DMSO","LPA Receptor","GPCR & G Protein","Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.",488.98,"355025-13-7",{"v":96,"d":"96.00"},196.33,"<1","N/A","http://selleckchem.com/products/ki16198.html","C24H25ClN2O5S","free base","N/A","COC(=O)CCSCC1=CC=C(C=C1)C2=C(NC(=O)OC(C)C3=C(Cl)C=CC=C3)C(=NO2)C",5.269,6,1,11]
["S2907","Pirfenidone (S-7701)","c4","L3900-13","in 10mM DMSO","CCR,TGF-beta/Smad","TGF-beta/Smad","Pirfenidone (S-7701, AMR-69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.",185.22,"53179-13-8",{"v":37,"d":"37.00"},199.76,"<1","N/A","http://selleckchem.com/products/pirfenidone.html","C12H11NO","free base","AMR-69","CC1=CN(C(=O)C=C1)C2=CC=CC=C2",1.905,1,0,1]
["S2910","Tempol","d4","L3900-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.",172.24,"2226-96-2",{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},"http://selleckchem.com/products/tempol-4-hydroxy-tempo.html","C9H18NO2","free base","4-Hydroxy-TEMPO","CC1(C)CC(O)CC(C)(C)N1[O]",0.413,0,1,0]
["S2914","Dapivirine (TMC120)","e4","L3900-13","in 10mM DMSO","Reverse Transcriptase","Microbiology","Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.",{"v":329.4,"d":"329.40"},"244767-67-7",{"v":34,"d":"34.00"},103.22,"<1","N/A","http://selleckchem.com/products/dapivirine.html","C20H19N5","free base","N/A","CC1=CC(=C(NC2=CC=NC(=N2)NC3=CC=C(C=C3)C#N)C(=C1)C)C",5.549,2,2,4]
["S2918","HC-030031","f4","L3900-13","in 10mM DMSO","TRP Channel","Transmembrane Transporters","HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.",355.39,"349085-38-7",{"v":32,"d":"32.00"},90.04,"<1","N/A","http://selleckchem.com/products/hc-030031.html","C18H21N5O3","free base","TOSLAB 829227","CC(C)C1=CC=C(NC(=O)C[N]2C=NC3=C2C(=O)N(C)C(=O)N3C)C=C1",{"v":1.73,"d":"1.730"},4,1,4]
["S2922","Icotinib (BPI-2009H)","g4","L3900-13","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Icotinib (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).",391.42,"610798-31-7",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/icotinib.html","C22H21N3O4","free base","BPI-2009H","C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C4OCCOCCOCCOC4=C3",4.128,6,1,2]
["S2924","Laduviglusib (CHIR-99021) HCl","h4","L3900-13","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.",{"v":501.8,"d":"501.80"},"1797989-42-4",{"v":93,"d":"93.00"},185.33,"<1","N/A","http://selleckchem.com/products/chir-99021-ct99021-hcl.html","C22H18Cl2N8.HCl","Hydrochloride","CT99021 HCl","Cl.CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=NC=C(C=C3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.858,4,3,7]
["S2925","Evacetrapib (LY2484595)","a5","L3900-13","in 10mM DMSO","CETP","Metabolism","Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.",638.65,"1186486-62-3",{"v":12.8,"d":"12.80"},20.04,"<1","N/A","http://selleckchem.com/products/evacetrapib-ly2484595.html","C31H36F6N6O2","free base","N/A","C[N]1N=NC(=N1)N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3CCCN(CC4CCC(CC4)C(O)=O)C5=C3C=C(C)C=C5C",8.617,4,0,9]
["S2926","TDZD-8","b5","L3900-13","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.",222.26,"327036-89-5",{"v":44.5,"d":"44.50"},200.22,"<1","N/A","http://selleckchem.com/products/tdzd-8.html","C10H10N2O2S","free base","NP 01139","CN1SC(=O)N(CC2=CC=CC=C2)C1=O",2.145,2,0,2]
["S2928","TAK-715","c5","L3900-13","in 10mM DMSO","p38 MAPK","MAPK","TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.",399.51,"303162-79-0",{"v":80,"d":"80.00"},200.25,"<1","N/A","http://selleckchem.com/products/tak-715.html","C24H21N3OS","free base","N/A","CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C",5.629,3,1,5]
["S3001","Clevudine","d5","L3900-13","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.",260.22,"163252-36-6",{"v":52,"d":"52.00"},199.83,{"v":52,"d":"52.00"},199.83,"http://selleckchem.com/products/clevudine-levovir.html","C10H13FN2O5","free base","Levovir,L-FMAU","CC1=CN(C2OC(CO)C(O)C2F)C(=O)NC1=O",-1.065,3,3,2]
["S3002","Rivaroxaban (BAY 59-7939)","e5","L3900-13","in 10mM DMSO","Factor Xa","Metabolism","Rivaroxaban (BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).",435.88,"366789-02-8",{"v":87,"d":"87.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/Rivaroxaban.html","C19H18ClN3O5S","free base","BAY 59-7939","ClC1=CC=C(S1)C(=O)NCC2CN(C(=O)O2)C3=CC=C(C=C3)N4CCOCC4=O",1.797,5,1,5]
["S3003","Prostaglandin E2 (PGE2)","f5","L3900-13","in 10mM DMSO","PGES,Prostaglandin Receptor","Endocrinology & Hormones","Prostaglandin E2 (PGE2, Dinoprostone,Prepidil) plays important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.",352.47,"363-24-6",{"v":70,"d":"70.00"},{"v":198.6,"d":"198.60"},{"v":40,"d":"40.00"},113.49,"http://selleckchem.com/products/prostaglandin-e2-cervidil.html","C20H32O5","free base","Dinoprostone,Prepidil","CCCCCC(O)/C=C/C1C(O)CC(=O)C1C\\C=C/CCCC(O)=O",3.199,2,2,12]
["S3005","Paroxetine HCl","g5","L3900-13","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.",365.83,"78246-49-8",{"v":73,"d":"73.00"},199.55,{"v":1,"d":"1.00"},2.73,"http://selleckchem.com/products/paroxetine-hcl.html","C19H20FNO3.HCl","Hydrochloride","BRL-29060A, FG-7051","Cl.FC1=CC=C(C=C1)C2CCNCC2COC3=CC4=C(OCO4)C=C3",3.611,3,1,4]
["S3008","Zaltoprofen","h5","L3900-13","in 10mM DMSO","COX","Neuronal Signaling","Zaltoprofen(CN100,Soleton) is an inhibitor of COX-1 and COX-2 for treatment of arthritis.",298.36,"74711-43-6",{"v":60,"d":"60.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://selleckchem.com/products/zaltoprofen.html","C17H14O3S","free base","CN100,Soleton","CC(C(O)=O)C1=CC2=C(SC3=CC=CC=C3C(=O)C2)C=C1",3.684,2,0,2]
["S3012","Pazopanib","a6","L3900-13","in 10mM DMSO","Autophagy,Cathepsin B,c-Kit,CSF-1R,Cysteine Protease,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.",437.52,"444731-52-6",{"v":87,"d":"87.00"},198.85,"<1","N/A","http://selleckchem.com/products/pazopanib.html","C21H23N7O2S","Free Base","GW786034","C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",3.741,5,2,5]
["S3015","Amoxicillin","b6","L3900-13","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.",{"v":365.4,"d":"365.40"},"26787-78-0",{"v":73,"d":"73.00"},199.78,"<1","N/A","http://selleckchem.com/products/amoxicillin-amoxycillin.html","C16H19N3O5S","Free Base","Amoxycillin","CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O",-2.539,3,3,4]
["S3017","Aspirin (NSC 27223)","c6","L3900-13","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3019","Ciclopirox ethanolamine","d6","L3900-13","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296,Ciclopiroxolamine) is a broad-spectrum antifungal agent working as an iron chelator.",268.35,"41621-49-2",{"v":6,"d":"6.00"},22.36,"<1","N/A","http://selleckchem.com/products/ciclopirox-ethanolamine.html","C12H17NO2.C2H7NO","Ethanolamine","Ciclopirox olamine, HOE 296,Ciclopiroxolamine","CC1=CC(=O)N(O)C(=C1)C2CCCCC2.NCCO",1.302,1,2,2]
["S3021","Rimonabant (SR141716)","e6","L3900-13","in 10mM DMSO","Acyltransferase,Bacterial,Cannabinoid Receptor,MmpL3,Transferase","GPCR & G Protein","Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.",463.79,"168273-06-1",{"v":25,"d":"25.00"},{"v":53.9,"d":"53.90"},"<1","N/A","http://selleckchem.com/products/rimonabant-sr141716.html","C22H21Cl3N4O","free base","SR141716","CC1=C([N](N=C1C(=O)NN2CCCCC2)C3=CC=C(Cl)C=C3Cl)C4=CC=C(Cl)C=C4",6.613,2,1,4]
["S3022","Cabazitaxel (XRP6258)","f6","L3900-13","in 10mM DMSO","Autophagy,Microtubule Associated","Cytoskeletal Signaling","Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.",835.93,"183133-96-2",{"v":100,"d":"100.00"},119.63,"<1","N/A","http://selleckchem.com/products/cabazitaxel-jevtana.html","C45H57NO14","free base","RPR-116258A, TXD 258, Taxoid XRP6258","COC1CC2OCC2(OC(C)=O)C3C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(OC)C(=O)C13C)C5(C)C)C",3.403,12,2,15]
["S3024","Lamotrigine","g6","L3900-13","in 10mM DMSO","5-HT Receptor,Sodium Channel","Transmembrane Transporters","Lamotrigine (BW-430C,LTG) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.",256.09,"84057-84-1",{"v":10,"d":"10.00"},39.05,"<1","N/A","http://selleckchem.com/products/lamotrigine.html","C9H7Cl2N5","free base","BW-430C,LTG","NC1=NC(=C(N=N1)C2=CC=CC(=C2Cl)Cl)N",2.426,3,2,1]
["S3026","Piceatannol","h6","L3900-13","in 10mM DMSO","Arginase,Syk","Angiogenesis","Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.",244.24,"10083-24-6",{"v":48,"d":"48.00"},196.53,"<1","N/A","http://selleckchem.com/products/piceatannol.html","C14H12O4","free base","N/A","OC1=CC(=CC(=C1)/C=C/C2=CC=C(O)C(=C2)O)O",2.848,0,4,2]
["S3030","Niclosamide (BAY2353)","a7","L3900-13","in 10mM DMSO","Autophagy,STAT","JAK/STAT","Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).",327.12,"50-65-7",{"v":8,"d":"8.00"},24.46,"<1","N/A","http://www.selleck.cn/products/niclosamide-niclocide.html","C13H8Cl2N2O4","Free Base","Niclocide, NSC 178296","OC1=CC=C(Cl)C=C1C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.595,1,2,3]
["S3031","Linagliptin (BI-1356)","b7","L3900-13","in 10mM DMSO","Autophagy,Ferroptosis","Proteases","Linagliptin (BI-1356,GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.",472.54,"668270-12-0",{"v":17,"d":"17.00"},35.98,"<1","N/A","http://selleckchem.com/products/linagliptin-bi-1356.html","C25H28N8O2","free base","GSK2118436","CC#CC[N]1C(=NC2=C1C(=O)N(CC3=NC4=CC=CC=C4C(=N3)C)C(=O)N2C)N5CCCC(N)C5",2.718,5,1,5]
["S3032","Bindarit (AF 2838)","c7","L3900-13","in 10mM DMSO","CCR,Immunology & Inflammation related","Immunology & Inflammation","Bindarit (AF 2838) exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.",324.37,"130641-38-2",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/bindarit.html","C19H20N2O3","free base","AF 2838","CC(C)(OCC1=N[N](CC2=CC=CC=C2)C3=C1C=CC=C3)C(O)=O",3.559,3,0,6]
["S3033","Vildagliptin (LAF-237)","d7","L3900-13","in 10mM DMSO","DPP","Proteases","Vildagliptin (LAF-237,NVP-LAF 237) inhibits DPP−4 with IC50 of 2.3 nM.",{"v":303.4,"d":"303.40"},"274901-16-5",{"v":60,"d":"60.00"},197.76,{"v":60,"d":"60.00"},197.76,"http://selleckchem.com/products/vildagliptin-laf-237.html","C17H25N3O2","free base","NVP-LAF 237","O[C]12CC3[CH2]C(C1)C[C](C3)(C2)NCC(=O)N4CCCC4C#N",0.179,1,1,3]
["S3035","Daunorubicin (RP 13057) HCl","e7","L3900-13","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,COVID-19,DNA/RNA Synthesis,Topoisomerase","DNA Damage/DNA Repair","Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.",563.98,"23541-50-6",{"v":100,"d":"100.00"},177.31,{"v":100,"d":"100.00"},177.31,"http://selleckchem.com/products/daunorubicin-hcl-daunomycin-hcl.html","C27H29NO10.HCl","Hydrochloride","Daunomycin HCl, Rubidomycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(C)=O)O)C(=O)C2=CC=C1",{"v":1.01,"d":"1.010"},6,4,4]
["S3036","Pravastatin sodium","f7","L3900-13","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.",446.51,"81131-70-6",{"v":89,"d":"89.00"},199.32,{"v":89,"d":"89.00"},199.32,"http://selleckchem.com/products/pravastatin-pravachol.html","C23H35O7.Na","sodium","CS-514 Sodium","[Na+].CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC([O-])=O)C12",0.682,2,3,11]
["S3037","Bepotastine Besilate","g7","L3900-13","in 10mM DMSO","COVID-19,Histamine Receptor","Neuronal Signaling","Bepotastine Besilate (TAU 284) is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.",547.06,"190786-44-8",{"v":109,"d":"109.00"},199.25,"<1","N/A","http://selleckchem.com/products/bepotastine-besilate.html","C21H25ClN2O3.C6H6O3S","Besilate salt","TAU 284","OC(=O)CCCN1CCC(CC1)OC(C2=CC=C(Cl)C=C2)C3=NC=CC=C3.O[S](=O)(=O)C4=CC=CC=C4",1.371,3,0,9]
["S3038","Fosaprepitant dimeglumine salt","h7","L3900-13","in 10mM DMSO","Neurokinin Receptor","Neuronal Signaling","Fosaprepitant dimeglumine salt (MK-0517) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.",1004.83,"265121-04-8",{"v":201,"d":"201.00"},200.03,{"v":135,"d":"135.00"},134.35,"http://selleckchem.com/products/fosaprepitant.html","C23H22F7N4O6P.2C7H17NO5","dimeglumine salt","MK-0517","CNCC(O)C(O)C(O)C(O)CO.CNCC(O)C(O)C(O)C(O)CO.CC(OC1OCCN(CC2=NN(C(=O)N2)[P](O)(O)=O)C1C3=CC=C(F)C=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",-1.235,4,13,21]
["S3043","Rofecoxib","a8","L3900-13","in 10mM DMSO","COX","Neuronal Signaling","Rofecoxib (MK-0966) is a COX-2 inhibitor with IC50 of 18 nM.",314.36,"162011-90-7",{"v":63,"d":"63.00"},200.41,"<1","N/A","http://selleckchem.com/products/rofecoxib-vioxx.html","C17H14O4S","free base","MK-0966","C[S](=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3",2.871,4,0,3]
["S3045","Cinepazide maleate","b8","L3900-13","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.",533.57,"26328-04-1",{"v":107,"d":"107.00"},200.54,{"v":107,"d":"107.00"},200.54,"http://selleckchem.com/products/cinepazide-maleate.html","C22H31N3O5.C4H4O4","Maleate","N/A","COC1=C(OC)C(=CC(=C1)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3)OC.OC(=O)\\C=C/C(O)=O",{"v":-1.65,"d":"-1.650"},7,0,9]
["S3046","Azilsartan","c8","L3900-13","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.",456.45,"147403-03-0",{"v":91,"d":"91.00"},199.36,"<1","N/A","http://selleckchem.com/products/azilsartan-tak-536.html","C25H20N4O5","free base","TAK-536","CCOC1=NC2=CC=CC(=C2[N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(O)=O",4.662,6,1,7]
["S3051","Bosentan Hydrate","d8","L3900-13","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Bosentan (Ro 47-0203) is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.",569.63,"157212-55-0",{"v":100,"d":"100.00"},175.55,{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},"http://selleckchem.com/products/bosentan-hydrate.html","C27H29N5O6S.H2O","Hydrate","Ro 47-0203","O.COC1=CC=CC=C1OC2=C(OCCO)N=C(N=C2N[S](=O)(=O)C3=CC=C(C=C3)C(C)(C)C)C4=NC=CC=N4",3.741,9,2,11]
["S3052","Rupatadine Fumarate","e8","L3900-13","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively.",532.03,"182349-12-8",{"v":9,"d":"9.00"},16.92,"<1","N/A","http://selleckchem.com/products/rupatadine-fumarate.html","C26H26ClN3.C4H4O4","Fumarate","N/A","CC1=CN=CC(=C1)CN2CCC(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C35.OC(=O)\\C=C\\C(O)=O",2.672,4,0,4]
["S3053","Azelnidipine","f8","L3900-13","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.",582.65,"123524-52-7",{"v":117,"d":"117.00"},200.81,"<1","N/A","http://selleckchem.com/products/azelnidipine.html","C33H34N4O6","free base","UR-12592","CC(C)OC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC3CN(C3)C(C4=CC=CC=C4)C5=CC=CC=C5)N",4.941,4,2,11]
["S3054","Alverine Citrate","g8","L3900-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.",473.56,"5560-59-8",{"v":95,"d":"95.00"},200.61,"<1","N/A","http://selleckchem.com/products/alverine-citrate.html","C20H27N.C6H8O7","Citrate","NSC 35459","CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.037,3,0,14]
["S3057","Azilsartan Medoxomil","h8","L3900-13","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.",568.53,"863031-21-4",{"v":114,"d":"114.00"},200.52,"<1","N/A","http://selleckchem.com/products/azilsartan-medoxomil-tak-491.html","C30H24N4O8","free base","TAK-491","CCOC1=NC2=CC=CC(=C2[N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)OCC6=C(C)OC(=O)O6",{"v":5.27,"d":"5.270"},10,1,10]
["S3061","Epinephrine HCl","a9","L3900-13","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Epinephrine HCl (Adrenaline) is a hormone and a neurotransmitter.",219.67,"55-31-2",{"v":44,"d":"44.00"},{"v":200.3,"d":"200.30"},{"v":44,"d":"44.00"},{"v":200.3,"d":"200.30"},"http://selleckchem.com/products/epinephrine-hcl-adrenaline.html","C9H13NO3.HCl","HCl","Adrenaline","Cl.CNCC(O)C1=CC=C(O)C(=C1)O",0.754,0,4,3]
["S3062","Diclofenac Potassium","b9","L3900-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.",334.24,"15307-81-0",{"v":69,"d":"69.00"},206.44,{"v":10,"d":"10.00"},29.92,"http://selleckchem.com/products/diclofenac-potassium.html","C14H10Cl2KNO2","Potassium","CGP-45840B","[K+].[O-]C(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl",2.899,0,1,4]
["S3063","Diclofenac Diethylamine","c9","L3900-13","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.",369.29,"78213-16-8",{"v":74,"d":"74.00"},200.38,"<1","N/A","http://selleckchem.com/products/diclofenac-diethylamine.html","C14H11Cl2NO2.C4H11N","Diethylamine","N/A","CCNCC.OC(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl",{"v":2.15,"d":"2.150"},1,2,6]
["S3066","Naloxone HCl","d9","L3900-13","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.",363.84,"357-08-4",{"v":72,"d":"72.00"},197.89,{"v":72,"d":"72.00"},197.89,"http://selleckchem.com/products/naloxone-hcl.html","C19H21NO4.HCl","HCl","N/A","Cl.OC1=C2OC3C(=O)CCC4(O)C5CC(=C2C34CCN5CC=C)C=C1",1.835,2,1,2]
["S3067","Chlorhexidine 2HCl","e9","L3900-13","in 10mM DMSO","Anti-infection","Microbiology","Chlorhexidine hydrochloride (NSC-185) is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.",578.37,"3697-42-5",{"v":100,"d":"100.00"},{"v":172.9,"d":"172.90"},"<1","N/A","http://selleckchem.com/products/chlorhexidine-hcl.html","C22H30Cl2N10.2HCl","HCl","NSC-185","Cl.Cl.ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1",5.137,0,6,17]
["S3070","Piracetam","f9","L3900-13","in 10mM DMSO","GluR","Neuronal Signaling","Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.",142.16,"7491-74-9",{"v":72,"d":"72.00"},506.47,{"v":72,"d":"72.00"},506.47,"http://selleckchem.com/products/piracetam.html","C6H10N2O2","free base","UCB 6215","NC(=O)CN1CCCC1=O",-1.312,2,1,2]
["S3077","Tazobactam","g9","L3900-13","in 10mM DMSO","Selection Antibiotics for Transfected Cell,β-lactamase","Microbiology","Tazobactam (Tazobactam acid, Tazobactamum) is a β-lactamases Inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect.",300.29,"89786-04-9",{"v":60,"d":"60.00"},199.81,"<1","N/A","http://selleckchem.com/products/tazobactam.html","C10H12N4O5S","free base","Tazobactam acid, Tazobactamum","CC1(C[N]2C=CN=N2)C(N3C(CC3=O)[S]1(=O)=O)C(O)=O",-1.189,6,0,3]
["S3078","Beclomethasone dipropionate","h9","L3900-13","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Beclomethasone dipropionate(Beclovent,Beconase,Vancenase)  is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.",521.04,"5534-09-8",{"v":104,"d":"104.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/beclomethasone-dipropionate.html","C28H37ClO7","free base","Beclometasone dipropionate,Beclovent,Beconase,Vancenase","CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC12C",4.064,6,1,8]
["S3079","Atovaquone","a10","L3900-13","in 10mM DMSO","COVID-19,Fungal,Parasite","Microbiology","Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.",366.84,"95233-18-4",{"v":5,"d":"5.00"},13.63,"<1","N/A","http://selleckchem.com/products/atovaquone-atavaquone.html","C22H19ClO3","free base","Atavaquone","OC1=C(C2CCC(CC2)C3=CC=C(Cl)C=C3)C(=O)C4=C(C=CC=C4)C1=O",5.319,2,1,2]
["S3080","Etravirine (TMC125)","b10","L3900-13","in 10mM DMSO","Reverse Transcriptase","Microbiology","Etravirine (TMC125, R-165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.",435.28,"269055-15-4",{"v":42,"d":"42.00"},96.49,"<1","N/A","http://selleckchem.com/products/etravirine-tmc125.html","C20H15BrN6O","free base","R-165335","CC1=CC(=CC(=C1OC2=C(Br)C(=NC(=N2)NC3=CC=C(C=C3)C#N)N)C)C#N",5.492,3,2,4]
["S3081","Ulipristal Acetate (CDB 2914)","c10","L3900-13","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.",475.62,"126784-99-4",{"v":83,"d":"83.00"},191.43,"<1","N/A","http://selleckchem.com/products/ulipristal.html","C30H37NO4","free base","HRP 2000, RU 44675","CN(C)C1=CC=C(C=C1)C2CC3(C)C(CCC3(OC(C)=O)C(C)=O)C4CCC5=CC(=O)CCC5=C24",4.309,2,0,3]
["S3083","Indacaterol Maleate","d10","L3900-13","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.",508.56,"753498-25-8",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/indacaterol-maleate.html","C24H28N2O3.C4H4O4","Maleate","QAB149","CCC1=CC2=C(CC(C2)NCC(O)C3=CC=C(O)C4=C3C=CC(=O)N4)C=C1CC.OC(=O)\\C=C/C(O)=O",1.264,3,4,8]
["S3104","Moguisteine","e10","L3900-13","in 10mM DMSO","Others","Others","Moguisteine(BBR-2173) is a novel peripheral non-narcotic antitussive drug.",339.41,"119637-67-1",{"v":68,"d":"68.00"},200.35,"<1","N/A","http://selleckchem.com/products/moguisteine.html","C16H21NO5S","free base","BBR-2173","CCOC(=O)CC(=O)N1CCSC1COC2=CC=CC=C2OC",2.212,5,0,8]
["S3105","Nadifloxacin","f10","L3900-13","in 10mM DMSO","Antibiotics","Microbiology","Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.",360.38,"124858-35-1",{"v":20,"d":"20.00"},{"v":55.5,"d":"55.50"},"<1","N/A","http://selleckchem.com/products/nadifloxacin.html","C19H21FN2O4","free base","OPC-7251","CC1CCC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCC(O)CC4)F",1.865,2,1,2]
["S3113","Pyridoxine HCl","g10","L3900-13","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine HCl (Vitamin B6,Pyridoxol hydrochloride) is a form of vitamin B6.",205.64,"58-56-0",{"v":41,"d":"41.00"},199.38,{"v":41,"d":"41.00"},199.38,"http://selleckchem.com/products/pyridoxine-hydrochloride.html","C8H11NO3.HCl","Hydrochloride","Vitamin B6,Pyridoxol hydrochloride","Cl.CC1=C(O)C(=C(CO)C=N1)CO",-0.108,1,3,2]
["S3117","Oxybutynin hydrochloride","h10","L3900-13","in 10mM DMSO","AChR","Neuronal Signaling","Oxybutynin(MJ4309-1) is an anticholinergic medication used to relieve urinary and bladder difficulties.",393.95,"1508-65-2",{"v":79,"d":"79.00"},200.53,{"v":4,"d":"4.00"},10.15,"https://www.selleckchem.com/products/oxybutynin-hydrochloride.html","C22H31NO3.HCl","hydrochloride","MJ4309-1","Cl.CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)C2=CC=CC=C2",5.028,2,0,10]
["S3120","Doxepin HCl","a11","L3900-13","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo.",315.84,"1229-29-4",{"v":63,"d":"63.00"},199.47,{"v":63,"d":"63.00"},199.47,"http://selleckchem.com/products/doxepin-hydrochloride-sinequan.html","C19H21NO.HCl","hydrochloride","N/A","Cl.CN(C)CC\\C=C1/C2=CC=CC=C2COC3=C1C=CC=C3",{"v":4.29,"d":"4.290"},1,0,3]
["S3121","Ornidazole","b11","L3900-13","in 10mM DMSO","Bacterial","Microbiology","Ornidazole (Ro7-0207, NSC 95075) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.",219.63,"16773-42-5",{"v":44,"d":"44.00"},200.34,{"v":2,"d":"2.00"},9.11,"http://selleckchem.com/products/ornidazole.html","C7H10ClN3O3","free base","Ro7-0207, NSC 95075","CC1=NC=C([N]1CC(O)CCl)[N+]([O-])=O",0.357,1,1,4]
["S3124","Dexamethasone Acetate","c11","L3900-13","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3129","Trimethoprim","d11","L3900-13","in 10mM DMSO","Antibiotics,Bacterial,DHFR","Microbiology","Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.",290.32,"738-70-5",{"v":58,"d":"58.00"},199.78,"<1","N/A","http://selleckchem.com/products/trimethoprim.html","C14H18N4O3","free base","BW 56-72, NIH 204, NSC-106568","COC1=C(OC)C(=CC(=C1)CC2=CN=C(N)N=C2N)OC",1.543,5,2,5]
["S3130","Biotin (Vitamin B7)","e11","L3900-13","in 10mM DMSO","Dyes,Vitamin","Metabolism","Biotin(Vitamin B7) is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.",244.31,"58-85-5",{"v":49,"d":"49.00"},200.56,"<1","N/A","http://selleckchem.com/products/biotin-vitamin-b7.html","C10H16N2O3S","free base","N/A","OC(=O)CCCCC1SCC2NC(=O)NC12",{"v":0.67,"d":"0.670"},2,2,5]
["S3137","Sodium salicylate","f11","L3900-13","in 10mM DMSO","NF-κB","NF-κB","Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.",161.11,"54-21-7",{"v":32,"d":"32.00"},198.62,{"v":32,"d":"32.00"},198.62,"http://selleckchem.com/products/sodium-salicylate.html","C7H6O3.Na","sodium salt","2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt","[NaH].OC(=O)C1=CC=CC=C1O",1.217,1,1,1]
["S3140","Milnacipran HCl","g11","L3900-13","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.",282.81,"101152-94-7",{"v":57,"d":"57.00"},201.55,{"v":57,"d":"57.00"},201.55,"http://selleckchem.com/products/milnacipran-hydrochloride.html","C15H22N2O.HCl","HCl","N/A","Cl.CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2",{"v":1.67,"d":"1.670"},1,1,5]
["S3144","Darifenacin HBr","h11","L3900-13","in 10mM DMSO","AChR","Neuronal Signaling","Darifenacin HBr (UK-88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.",507.46,"133099-07-7",{"v":100,"d":"100.00"},197.06,"<1","N/A","http://selleckchem.com/products/darifenacin-hydrobromide.html","C28H30N2O2.HBr","HBr","UK-88525","Br.NC(=O)C(C1CCN(CCC2=CC=C3OCCC3=C2)C1)(C4=CC=CC=C4)C5=CC=CC=C5",5.048,2,1,7]
["S3147","Entacapone","a2","L3900-14","in 10mM DMSO","COMT,Histone Methyltransferase","Epigenetics","Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.",305.29,"130929-57-6",{"v":61,"d":"61.00"},199.81,"<1","N/A","http://selleckchem.com/products/entacapone.html","C14H15N3O5","free base","OR-611","CCN(CC)C(=O)\\C(=C\\C1=CC(=C(O)C(=C1)O)[N+]([O-])=O)C#N",1.658,1,2,5]
["S3149","Estradiol valerate","b2","L3900-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol(E2V) is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.",{"v":356.5,"d":"356.50"},"979-32-8",{"v":71,"d":"71.00"},199.16,"<1","N/A","http://selleckchem.com/products/estradiol-valerate.html","C23H32O3","free base","E2V","CCCCC(=O)OC1CCC2C3CCC4=CC(=CC=C4C3CCC12C)O",5.796,2,1,5]
["S3150","Articaine HCl","c2","L3900-14","in 10mM DMSO","NF-κB","Immunology & Inflammation","Articaine (Ultracaine) is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.",320.84,"23964-57-0",{"v":64,"d":"64.00"},199.48,{"v":64,"d":"64.00"},199.48,"http://selleckchem.com/products/articaine-hydrochloride.html","C13H20N2O3S.HCl","Hydrochloride","Ultracaine","Cl.CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC",2.454,3,2,7]
["S3151","Gliquidone","d2","L3900-14","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.",527.63,"33342-05-1",{"v":105,"d":"105.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/gliquidone.html","C27H33N3O6S","free base","Glurenorm,AR-DF 26","COC1=CC2=C(C=C1)C(C)(C)C(=O)N(CCC3=CC=C(C=C3)[S](=O)(=O)NC(=O)NC4CCCCC4)C2=O",4.214,6,2,7]
["S3154","Butenafine HCl","e2","L3900-14","in 10mM DMSO","Fungal","Microbiology","Butenafine HCl (KP-363) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.",353.93,"101827-46-7",{"v":70,"d":"70.00"},197.78,"<1","N/A","http://selleckchem.com/products/butenafine-hydrochloride.html","C23H27N.HCl","HCl","KP-363","Cl.CN(CC1=CC=C(C=C1)C(C)(C)C)CC2=C3C=CC=CC3=CC=C2",6.177,0,0,5]
["S3155","Mepivacaine HCl","f2","L3900-14","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Mepivacaine is a tertiary amine used as a local anesthetic.",282.81,"1722-62-9",{"v":3,"d":"3.00"},10.61,{"v":57,"d":"57.00"},201.55,"http://selleckchem.com/products/mepivacaine-hydrochloride.html","C15H22N2O.HCl","HCl","N/A","Cl.CN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",3.363,1,1,2]
["S3160","Ethynodiol diacetate","g2","L3900-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ethynodiol diacetate (8080 CB,Ethynodiol acetate) is one of the first synthetic progestogens used in contraceptive pills.",384.51,"297-76-7",{"v":77,"d":"77.00"},200.25,{"v":77,"d":"77.00"},200.25,"http://selleckchem.com/products/ethynodiol-diacetate.html","C24H32O4","free base","8080 CB,Ethynodiol acetate","CC(=O)OC1CCC2C3CCC4(C)C(CCC4(OC(C)=O)C#C)C3CCC2=C1",4.973,4,0,4]
["S3161","Sertaconazole nitrate","h2","L3900-14","in 10mM DMSO","Fungal","Microbiology","Sertaconazole nitrate (FI-7045,FI7056) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.",500.78,"99592-39-9",{"v":100,"d":"100.00"},199.69,"<1","N/A","http://selleckchem.com/products/sertaconazole-nitrate.html","C20H15Cl3N2OS.HNO3","Nitrate","FI-7045,FI7056","O[N+]([O-])=O.ClC1=CC=C(C(C[N]2C=CN=C2)OCC3=CSC4=C(Cl)C=CC=C34)C(=C1)Cl",4.584,2,0,6]
["S3163","Benztropine mesylate","a3","L3900-14","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Benztropine(Cogentin mesylate, Benztropine methanesulfonate) is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.",403.53,"132-17-2",{"v":50,"d":"50.00"},123.91,{"v":81,"d":"81.00"},200.73,"http://selleckchem.com/products/benztropine-mesylate.html","C21H25NO.CH4SO3","Mesylate","Cogentin mesylate, Benztropine methanesulfonate","CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.C[S](O)(=O)=O",3.461,1,0,4]
["S3170","Ampicillin sodium","b3","L3900-14","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Ampicillin(D-(-)-α-Aminobenzylpenicillin sodium salt) is a beta-lactam antibiotic that is part of the aminopenicillin family.",371.39,"69-52-3",{"v":37,"d":"37.00"},99.63,{"v":74,"d":"74.00"},199.25,"http://selleckchem.com/products/ampicillin-sodium.html","C16H18N3NaO4S","Sodium","D-(-)-α-Aminobenzylpenicillin sodium salt","[Na+].CC1(C)SC2C(NC(=O)C(N)C3=CC=CC=C3)C(=O)N2C1C([O-])=O",-1.292,2,2,4]
["S3172","Anagrelide HCl","c3","L3900-14","in 10mM DMSO","PDE","Metabolism","Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.",292.55,"58579-51-4",{"v":14,"d":"14.00"},47.86,"<1","N/A","http://selleckchem.com/products/anagrelide-hydrochloride.html","C10H7Cl2N3O.HCl","Hydrochloride","BL-4162A,BMY 26538-01","Cl.ClC1=CC=C2NC3=NC(=O)CN3CC2=C1Cl",2.347,2,1,0]
["S3173","Antipyrine","d3","L3900-14","in 10mM DMSO","COX","Neuronal Signaling","Antipyrine (Phenazone,Phenazon) is an analgesic and antipyretic agent; selective COX-3 inhibitor.",188.23,"60-80-0",{"v":38,"d":"38.00"},201.88,{"v":38,"d":"38.00"},201.88,"http://selleckchem.com/products/antipyrine.html","C11H12N2O","free base","Phenazone,Phenazon","CN1N(C(=O)C=C1C)C2=CC=CC=C2",1.218,1,0,1]
["S3175","Atomoxetine HCl","e3","L3900-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.",291.82,"82248-59-7",{"v":58,"d":"58.00"},198.75,{"v":2,"d":"2.00"},6.85,"http://selleckchem.com/products/atomoxetine-hydrochloride.html","C17H21NO.HCl","HCl","LY 139603 HCl","Cl.CNCCC(OC1=CC=CC=C1C)C2=CC=CC=C2",3.959,1,1,6]
["S3176","Betahistine 2HCl","f3","L3900-14","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Betahistine (PT-9) is a histamine H3 receptor inhibitor with IC50 of 1.9 μM.",209.12,"5579-84-0",{"v":38,"d":"38.00"},181.71,{"v":38,"d":"38.00"},181.71,"http://selleckchem.com/products/betahistine-dihydrochloride.html","C8H12N2.2HCl","2HCl","PT-9","Cl.Cl.CNCCC1=NC=CC=C1",1.444,1,1,3]
["S3178","Brinzolamide","g3","L3900-14","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.",383.51,"138890-62-7",{"v":77,"d":"77.00"},200.78,"<1","N/A","http://selleckchem.com/products/brinzolamide.html","C12H21N3O5S3","free base","AL-4862","CCNC1CN(CCCOC)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",-0.772,5,2,7]
["S3180","Eletriptan HBr","h3","L3900-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Eletriptan (UK-116044) is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.",463.43,"177834-92-3",{"v":93,"d":"93.00"},200.68,"<1","N/A","http://selleckchem.com/products/eletriptan-hydrobromide.html","C22H26N2O2S.HBr","HBr","UK-116044","Br.CN1CCCC1CC2=C[NH]C3=C2C=C(CC[S](=O)(=O)C4=CC=CC=C4)C=C3",4.929,2,1,6]
["S3183","Amitriptyline HCl","a4","L3900-14","in 10mM DMSO","5-HT Receptor,Histamine Receptor,Serotonin Transporter","Neuronal Signaling","Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).",313.86,"549-18-8",{"v":63,"d":"63.00"},200.73,{"v":15,"d":"15.00"},47.79,"http://selleckchem.com/products/amitriptyline-hydrochloride.html","C20H23N.HCl","HCl","N/A","Cl.CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C13",5.154,0,0,3]
["S3189","Ropinirole HCl","b4","L3900-14","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Ropinirole (SKF-101468A) a selective dopamine D2 receptors agonist with Ki of 29 nM.",296.84,"91374-20-8",{"v":10,"d":"10.00"},33.69,{"v":60,"d":"60.00"},202.13,"http://selleckchem.com/products/ropinirole-hydrochloride.html","C16H24N2O.HCl","HCl","SKF-101468A","Cl.CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2",3.341,1,1,7]
["S3193","Ticarcillin sodium","c4","L3900-14","in 10mM DMSO","Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Ticarcillin (AB 2288, BRL 2288) is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.",430.41,"29457-07-6",{"v":86,"d":"86.00"},199.81,{"v":86,"d":"86.00"},199.81,"http://selleckchem.com/products/ticarcillin-sodium.html","C15H16N2O6S2.2Na","Sodium","AB 2288, BRL 2288","[NaH].[NaH].CC1(C)SC2C(NC(=O)C(C(O)=O)C3=CSC=C3)C(=O)N2C1C(O)=O",0.392,4,1,5]
["S3199","Reboxetine mesylate","d4","L3900-14","in 10mM DMSO","Others","Endocrinology & Hormones","Reboxetine (PNU 155950E) is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.",{"v":409.5,"d":"409.50"},"98769-84-7",{"v":82,"d":"82.00"},200.24,{"v":82,"d":"82.00"},200.24,"http://selleckchem.com/products/reboxetine-mesylate.html","C19H23NO3.CH4O3S","Mesylate","PNU 155950E, FCE20124 mesylate","CCOC1=C(OC(C2CNCCO2)C3=CC=CC=C3)C=CC=C1.C[S](O)(=O)=O",2.663,3,1,6]
["S3200","Triflusal","e4","L3900-14","in 10mM DMSO","COX","Immunology & Inflammation","Triflusal (UR1501) irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.",248.16,"322-79-2",{"v":50,"d":"50.00"},201.48,"<1","N/A","http://selleckchem.com/products/triflusal.html","C10H7F3O4","free base","UR1501","CC(=O)OC1=CC(=CC=C1C(O)=O)C(F)(F)F",2.169,3,0,4]
["S3201","Trifluoperazine 2HCl","f4","L3900-14","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).",480.42,"440-17-5",{"v":88,"d":"88.00"},183.17,{"v":96,"d":"96.00"},199.83,"http://selleckchem.com/products/trifluoperazine-dihydrochloride.html","C21H24F3N3S.2HCl","2HCl","SKF5019","Cl.Cl.CN1CCN(CCCN2C3=C(SC4=CC=C(C=C24)C(F)(F)F)C=CC=C3)CC1",5.739,0,0,5]
["S3207","Iopromide","g4","L3900-14","in 10mM DMSO","Others","Others","Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.",791.11,"73334-07-3",{"v":100,"d":"100.00"},{"v":126.4,"d":"126.40"},{"v":100,"d":"100.00"},{"v":126.4,"d":"126.40"},"http://selleckchem.com/products/iopromide.html","C18H24I3N3O8","free base","N/A","COCC(=O)NC1=C(I)C(=C(I)C(=C1I)C(=O)N(C)CC(O)CO)C(=O)NCC(O)CO",-1.057,4,6,11]
["S3208","Fexofenadine HCl","h4","L3900-14","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Fexofenadine (MDL 16455A) inhibits histamine H1 receptor with IC50 of 246 nM.",538.12,"153439-40-8",{"v":107,"d":"107.00"},198.84,{"v":2,"d":"2.00"},3.72,"http://selleckchem.com/products/fexofenadine-hcl.html","C32H39NO4.HCl","HCl","MDL 16455A","Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",2.989,1,1,10]
["S3212","Moclobemide (Ro 111163)","a5","L3900-14","in 10mM DMSO","MAO","Metabolism","Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.",268.74,"71320-77-9",{"v":53,"d":"53.00"},197.22,"<1","N/A","http://selleckchem.com/products/moclobemide.html","C13H17ClN2O2","free base","N/A","ClC1=CC=C(C=C1)C(=O)NCCN2CCOCC2",1.528,2,1,4]
["S3600","Schisandrin B (Sch B)","b5","L3900-14","in 10mM DMSO","ATM/ATR,P-gp","PI3K/Akt/mTOR","Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.",400.46,"61281-37-6",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://selleckchem.com/products/schisandrin-b.html","C23H28O6","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C4OCOC4=C3OC",5.067,6,0,4]
["S3603","Betulinic acid","c5","L3900-14","in 10mM DMSO","NF-κB,Topoisomerase","DNA Damage/DNA Repair","Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.",{"v":456.7,"d":"456.70"},"472-15-1",{"v":20,"d":"20.00"},43.79,"<1","N/A","http://selleckchem.com/products/betulinic-acid.html","C30H48O3","free base","ALS-357, Lupatic acid, Betulic acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C(O)=O",6.546,1,1,2]
["S3604","Triptolide (PG490)","d5","L3900-14","in 10mM DMSO","ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-κB","NF-κB","Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.",{"v":360.4,"d":"360.40"},"38748-32-2",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/triptolide.html","C20H24O6","free base","NSC 163062","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2O",0.872,5,1,1]
["S3608","Demethylzeylasteral (T-96)","e5","L3900-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.",480.59,"107316-88-1",{"v":96,"d":"96.00"},199.75,"<1","N/A","http://selleckchem.com/products/demethylzeylasteral-t-96.html","C29H36O6","free base","N/A","CC12CCC(C)(CC1C3(C)CCC4(C)C5=CC(=C(O)C(=C5C(=O)C=C4C3(C)CC2)C=O)O)C(O)=O",5.357,3,2,2]
["S3610","Cordycepin","f5","L3900-14","in 10mM DMSO","MMP","Proteases","Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.",251.24,"73-03-0",{"v":50,"d":"50.00"},199.01,{"v":25,"d":"25.00"},99.51,"http://selleckchem.com/products/cordycepin.html","C10H13N5O3","free base","3'-Deoxyadenosine","NC1=NC=NC2=C1N=C[N]2C3OC(CO)CC3O",-1.308,4,3,2]
["S3612","Rosmarinic acid","g5","L3900-14","in 10mM DMSO","Complement System,IκB/IKK","NF-κB","Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.",360.31,"20283-92-5",{"v":72,"d":"72.00"},199.83,{"v":24,"d":"24.00"},66.61,"http://selleckchem.com/products/rosmarinic-acid.html","C18H16O8","free base","Rosemary acid","OC(=O)C(CC1=CC=C(O)C(=C1)O)OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O",2.706,3,4,7]
["S3621","Pazufloxacin mesylate","h5","L3900-14","in 10mM DMSO","Bacterial","Microbiology","Pazufloxacin Mesylate (T-3762, Pazucross), also known as Pazucross and T-3762, is a quinolone antibacterial agent used for the intravenous therapy of several infections.",414.41,"163680-77-1",{"v":82,"d":"82.00"},197.87,{"v":82,"d":"82.00"},197.87,"http://selleckchem.com/products/pazufloxacin-mesylate.html","C16H15FN2O4.CH4O3S","methanesulfonate","T-3762, Pazucross","CC1COC2=C(C(=CC3=C2N1C=C(C(O)=O)C3=O)F)C4(N)CC4.C[S](O)(=O)=O",-1.899,3,1,2]
["S3622","Diammonium Glycyrrhizinate","a6","L3900-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.",856.99,"79165-06-3",{"v":100,"d":"100.00"},116.69,{"v":100,"d":"100.00"},116.69,"http://selleckchem.com/products/diammonium-glycyrrhizinate.html","C42H62O16.2H3N","ammonium salt","N/A","N.N.CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",-4.247,8,5,7]
["S3623","Ceftibuten dihydrate","b6","L3900-14","in 10mM DMSO","Bacterial","Microbiology","Ceftibuten Dihydrate(Sch-39720 dihydrate) is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity.",446.46,"118081-34-8",{"v":89,"d":"89.00"},199.35,"<1","N/A","https://www.selleckchem.com/products/ceftibuten-dihydrate.html","C15H18N4O8S2","Dihydrate salt","Sch-39720 dihydrate","O.O.NC1=NC(=CS1)C(=C/CC(O)=O)/C(=O)NC2C3SCC=C(N3C2=O)C(O)=O",-0.958,5,2,6]
["S3625","Tyramine","c6","L3900-14","in 10mM DMSO","TAAR","GPCR & G Protein","Tyramine (4-hydroxyphenethylamine, para-tyramine, mydrial, uteramin) is a naturally occurring trace amine derived from the amino acid tyrosine and acts as a catecholamine releasing agent.",137.18,"51-67-2",{"v":27,"d":"27.00"},196.82,"<1","N/A","http://selleckchem.com/products/tyramine.html","C8H11NO","free base","4-hydroxyphenethylamine, para-tyramine, mydrial, uteramin","NCCC1=CC=C(O)C=C1",1.015,0,2,2]
["S3635","Medroxyprogesterone","d6","L3900-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist.",344.49,"520-85-4",{"v":68,"d":"68.00"},197.39,"<1","N/A","http://selleckchem.com/products/medroxyprogesterone.html","C22H32O3","free base","MP","CC1CC2C(CCC3(C)C2CCC3(O)C(C)=O)C4(C)CCC(=O)C=C14",3.376,2,0,1]
["S3637","Cefpirome sulfate","e6","L3900-14","in 10mM DMSO","Bacterial","Microbiology","Cefpirome(HR-810 sulfate) is a fourth-generation cephalosporin and is considered highly active against Gram-negative bacteria.",612.66,"98753-19-6",{"v":100,"d":"100.00"},163.22,{"v":100,"d":"100.00"},163.22,"http://selleckchem.com/products/cefpirome-sulfate.html","C22H23N6O5S2.HO4S","sulfate","HR-810 sulfate","CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3=CC=CC4=C3CCC4)C5=CSC(=N5)N.O[S](O)(=O)=O",{"v":-0.65,"d":"-0.650"},5,2,7]
["S3639","Tacrine hydrochloride hydrate","f6","L3900-14","in 10mM DMSO","AChR,HNMT","Neuronal Signaling","Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.","198.26(free bases)","206658-92-6",{"v":50,"d":"50.00"},252.19,{"v":50,"d":"50.00"},252.19,"http://selleckchem.com/products/tacrine-hydrochloride-hydrate.html","C13H14N2.xHCl.xH2O","hydrochloride hydrate","Tacrine, Tetrahydroaminacrine, Tetrahydroaminoacridine","NC1=C2C=CC=CC2=NC3=C1CCCC3",4.258,1,1,0]
["S3647","Mafenide Acetate","g6","L3900-14","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.",246.28,"13009-99-9",{"v":49,"d":"49.00"},198.96,{"v":49,"d":"49.00"},198.96,"http://selleckchem.com/products/mafenide-acetate.html","C7H10N2O2S.C2H4O2","acetate","N/A","CC(O)=O.NCC1=CC=C(C=C1)[S](N)(=O)=O",-3.043,3,2,2]
["S3648","Amlexanox (AA-673)","h6","L3900-14","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK,TBK1","Immunology & Inflammation","Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.",298.29,"68302-57-8",{"v":59,"d":"59.00"},197.79,"<1","N/A","http://selleckchem.com/products/amlexanox.html","C16H14N2O4","free base","CHX-3673, Amoxanox","CC(C)C1=CC2=C(OC3=NC(=C(C=C3C2=O)C(O)=O)N)C=C1",2.969,4,1,2]
["S3653","Spermidine trihydrochloride","a7","L3900-14","in 10mM DMSO","Autophagy,NMDAR","Neuronal Signaling","Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).",254.63,"334-50-9",{"v":30,"d":"30.00"},117.82,{"v":50,"d":"50.00"},196.36,"http://selleckchem.com/products/spermidine-trihydrochloride.html","C7H19N3.3HCl","trihydrochloride","4-Azaoctamethylenediamine trihydrochloride","Cl.Cl.Cl.NCCCCNCCCN",-0.024,0,3,7]
["S3654","Tauroursodeoxycholic Acid (TUDCA)","b7","L3900-14","in 10mM DMSO","Mitochondrial Metabolism","Neuronal Signaling","Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).",{"v":499.7,"d":"499.70"},"14605-22-2",{"v":99,"d":"99.00"},198.12,{"v":30,"d":"30.00"},60.04,"http://selleckchem.com/products/tauroursodeoxycholic-acid.html","C26H45NO6S","free base","N/A","CC(CCC(=O)NCC[S](O)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",2.997,1,3,7]
["S3655","Cefepime Dihydrochloride Monohydrate","c7","L3900-14","in 10mM DMSO","Bacterial","Microbiology","Cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intra-abdominal infections.",{"v":571.5,"d":"571.50"},"123171-59-5",{"v":100,"d":"100.00"},174.98,{"v":1,"d":"1.00"},1.75,"http://selleckchem.com/products/cefepime-dihydrochloride-monohydrate.html","C19H25N6O5S2.HCl.Cl.H2O","dihydrochloride hydrate","N/A","O.Cl.Cl.CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3(C)CCCC3)C4=CSC(=N4)N",-2.421,5,2,7]
["S3656","Piribedil","d7","L3900-14","in 10mM DMSO","Adrenergic Receptor,Dopamine Receptor","Neuronal Signaling","Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.",298.34,"3605-01-4",{"v":59,"d":"59.00"},197.76,"<1","N/A","http://selleckchem.com/products/piribedil.html","C16H18N4O2","free base","Trivastal, Trivastan","C1OC2=CC=C(CN3CCN(CC3)C4=NC=CC=N4)C=C2O1",2.043,4,0,3]
["S3657","Promestriene","e7","L3900-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Promestriene (3-propyl ethyl, 17B-methyl estradiol) is a synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application.",328.49,"39219-28-8",{"v":65,"d":"65.00"},197.88,{"v":3,"d":"3.00"},9.13,"http://selleckchem.com/products/promestriene.html","C22H32O2","free base","3-propyl ethyl, 17B-methyl estradiol","CCCOC1=CC2=C(C=C1)C3CCC4(C)C(CCC4C3CC2)OC",5.344,2,0,4]
["S3658","O6-Benzylguanine","f7","L3900-14","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.",241.25,"19916-73-5",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/o6-benzylguanine.html","C12H11N5O","free base","O6-BG","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3=CC=CC=C3",1.646,4,2,3]
["S3659","Fludrocortisone acetate","g7","L3900-14","in 10mM DMSO","Others","Others","Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.",422.49,"514-36-3",{"v":84,"d":"84.00"},198.82,"<1","N/A","http://selleckchem.com/products/fludrocortisone-acetate.html","C23H31FO6","free base","9α-fluorocortisol acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC12C",1.791,4,1,4]
["S3666","Ilaprazole","h7","L3900-14","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.",366.44,"172152-36-2",{"v":73,"d":"73.00"},199.21,"<1","N/A","http://selleckchem.com/products/ilaprazole.html","C19H18N4O2S","free base","IY-81149","COC1=CC=NC(=C1C)C[S](=O)C2=NC3=C([NH]2)C=C(C=C3)[N]4C=CC=C4",3.311,4,1,5]
["S3668","Thymopentin","a8","L3900-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymopentin (TP5) has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.",679.77,"69558-55-0",{"v":100,"d":"100.00"},147.11,{"v":100,"d":"100.00"},147.11,"http://selleckchem.com/products/thymopentin.html","C30H49N9O9","free base","TP5","CC(C)C(NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC1=CC=C(O)C=C1)C(O)=O",-6.675,6,9,23]
["S3669","Carmustine","b8","L3900-14","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.",214.05,"154-93-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carmustine.html","C5H9Cl2N3O2","free base","bis-chloroethylnitrosourea, BCNU, BiCNU","ClCCNC(=O)N(CCCl)N=O",1.201,2,1,5]
["S3674","Levamlodipine","c8","L3900-14","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.",408.88,"103129-82-4",{"v":81,"d":"81.00"},{"v":198.1,"d":"198.10"},{"v":81,"d":"81.00"},{"v":198.1,"d":"198.10"},"http://selleckchem.com/products/levamlodipine.html","C20H25ClN2O5","free base","S-amlodipine","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C",1.576,5,2,10]
["S3676","Carbendazim","d8","L3900-14","in 10mM DMSO","Fungal","Microbiology","Carbendazim (Mercarzole, Carbendazole) is a broad-spectrum systemic antimycotic and can be used to control a broad range of diseases on field crops, fruits, and vegetables, including sclerotinia rot of canola, wheat head blight, peanut leaf spot, and SB on rice. Its mode of action is to inhibit the formation of mitotic microtubules in of fungi.",191.19,"10605-21-7",{"v":17,"d":"17.00"},88.92,"<1","N/A","http://selleckchem.com/products/carbendazim.html","C9H9N3O2","free base","Mercarzole, Carbendazole","COC(=O)NC1=NC2=C([NH]1)C=CC=C2",{"v":1.65,"d":"1.650"},3,2,2]
["S3681","Vitamin E Acetate","e8","L3900-14","in 10mM DMSO","Vitamin","Metabolism","Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant., Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. ,",472.74,"58-95-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e-acetate.html","C31H52O3","free base","Tocopherol acetate","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)OC(C)=O",{"v":10.45,"d":"10.450"},3,0,14]
["S3684","Methacholine chloride","f8","L3900-14","in 10mM DMSO","AChR","Neuronal Signaling","Methacholine (Mecholyl, Acetyl-β-methylcholine) is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system but has little effects on the nicotinic receptors.",195.69,"62-51-1",{"v":39,"d":"39.00"},199.29,{"v":39,"d":"39.00"},199.29,"http://selleckchem.com/products/methacholine-chloride.html","C8H18NO2.Cl","chloride","Mecholyl chloride, Acetyl-β-methylcholine chloride","[Cl-].CC(C[N+](C)(C)C)OC(C)=O",-3.492,2,0,4]
["S3692","N-Ethylmaleimide (NEM)","g8","L3900-14","in 10mM DMSO","Cysteine Protease,DUB","Proteases","N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.",125.13,"128-53-0",{"v":25,"d":"25.00"},199.79,{"v":25,"d":"25.00"},199.79,"http://selleckchem.com/products/n-ethylmaleimide-nem.html","C6H7NO2","free base","N/A","CCN1C(=O)C=CC1=O",{"v":0.16,"d":"0.160"},2,0,1]
["S3693","2,6-Dihydroxypurine","h8","L3900-14","in 10mM DMSO","Others","Others","2,6-Dihydroxypurine (Xanthine, Isoxanthine) is a purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is a product on the pathway of purine degradation.",152.11,"69-89-6",{"v":2,"d":"2.00"},13.15,"<1","N/A","http://selleckchem.com/products/2-6-dihydroxypurine.html","C5H4N4O2","free base","Xanthine, Isoxanthine","O=C1NC(=O)C2=C(N1)N=C[NH]2",-0.718,3,3,0]
["S3697","Mafenide hydrochloride","a9","L3900-14","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.",222.69,"138-37-4",{"v":44,"d":"44.00"},197.58,{"v":44,"d":"44.00"},197.58,"http://selleckchem.com/products/mafenide-hydrochloride.html","C7H10N2O2S.HCl","hydrochloride","4-Aminomethylbenzenesulfonamide hydrochloride","Cl.NCC1=CC=C(C=C1)[S](N)(=O)=O",0.023,2,2,2]
["S3698","Nortriptyline hydrochloride","b9","L3900-14","in 10mM DMSO","Autophagy","Autophagy","Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.",299.84,"894-71-3",{"v":59,"d":"59.00"},196.77,{"v":59,"d":"59.00"},196.77,"http://selleckchem.com/products/nortriptyline-hydrochloride.html","C19H21N.HCl","hydrochloride","Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride","Cl.CNCCC=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.618,0,1,3]
["S3705","Chlorobutanol","c9","L3900-14","in 10mM DMSO","Fungal","Microbiology","Chlorobutanol (Chlorbutol, Chloreton, Chloretone, Chlortran|, trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic with antibacterial and antifungal properties.",177.46,"57-15-8",{"v":35,"d":"35.00"},197.23,"<1","N/A","http://selleckchem.com/products/chlorobutanol.html","C4H7Cl3O","free base","Chlorbutol, Chloreton, Chloretone, Chlortran","CC(C)(O)C(Cl)(Cl)Cl",1.822,0,0,1]
["S3706","Sarpogrelate hydrochloride","d9","L3900-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Sarpogrelate (MCI-9042) is a selective 5-HT2A antagonist with pKi values of 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively.",465.97,"135159-51-2",{"v":93,"d":"93.00"},199.58,{"v":93,"d":"93.00"},199.58,"http://selleckchem.com/products/sarpogrelate-hydrochloride.html","C24H31NO6.HCl","hydrochloride","MCI-9042","Cl.COC1=CC=CC(=C1)CCC2=C(OCC(CN(C)C)OC(=O)CCC(O)=O)C=CC=C2",1.427,5,0,14]
["S3711","Carbasalate Calcium","e9","L3900-14","in 10mM DMSO","Anti-infection","Microbiology","Carbasalate calcium (Iromin, Alcacyl, Omegin, Rheomin, Solupsan) is an analgesic, antipyretic, and anti-inflammatory drug as well as a platelet aggregation inhibitor.",458.43,"5749-67-7",{"v":11,"d":"11.00"},23.99,{"v":91,"d":"91.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/carbasalate-calcium.html","C18H14O8.CH4N2O.Ca","calcium salt","Iromin, Alcacyl, Omegin, Rheomin, Solupsan","CC(=O)OC1=C(C=CC=C1)C(=O)O[Ca]OC(=O)C2=C(OC(C)=O)C=CC=C2.NC(N)=O",1.594,9,2,10]
["S3713","Moxidectin","f9","L3900-14","in 10mM DMSO","Parasite","Microbiology","Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.",639.82,"113507-06-5",{"v":100,"d":"100.00"},156.29,"<1","N/A","http://selleckchem.com/products/moxidectin.html","C37H53NO8","free base","Milbemycin B","CO\\N=C1/CC2(CC3CC(C\\C=C(C)\\CC(C)/C=C/C=C/4COC5C(O)C(=CC(C(=O)O3)C45O)C)O2)OC(C1C)\\C(C)=C\\C(C)C",5.026,7,1,3]
["S3714","Lifitegrast","g9","L3900-14","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.",615.48,"1025967-78-5",{"v":100,"d":"100.00"},162.47,"<1","N/A","http://selleckchem.com/products/lifitegrast.html","C29H24Cl2N2O7S","free base","SAR1118,SHP-606","C[S](=O)(=O)C1=CC=CC(=C1)CC(NC(=O)C2=C(Cl)C=C3CN(CCC3=C2Cl)C(=O)C4=CC=C5C=COC5=C4)C(O)=O",{"v":4.79,"d":"4.790"},6,1,7]
["S3716","Flibanserin","h9","L3900-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Flibanserin (BIMT-17, BIMT-17-BS) is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors.",{"v":390.4,"d":"390.40"},"167933-07-5",{"v":78,"d":"78.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/flibanserin.html","C20H21F3N4O","free base","BIMT-17, BIMT-17-BS","FC(F)(F)C1=CC=CC(=C1)N2CCN(CC2)CCN3C(=O)NC4=C3C=CC=C4",3.609,1,1,5]
["S3719","Topiroxostat","a10","L3900-14","in 10mM DMSO","P450 (e.g. CYP17),Xanthine Oxidase","Metabolism","Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.",248.24,"577778-58-6",{"v":40,"d":"40.00"},161.13,"<1","N/A","http://selleckchem.com/products/topiroxostat.html","C13H8N6","free base","N/A","N#CC1=NC=CC(=C1)C2=N[NH]C(=N2)C3=CC=NC=C3",1.141,4,1,2]
["S3720","Elafibranor","b10","L3900-14","in 10mM DMSO","PPAR","Metabolism","Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation.",384.49,"923978-27-2",{"v":76,"d":"76.00"},197.66,"<1","N/A","http://selleckchem.com/products/elafibranor.html","C22H24O4S","free base","GFT505","CSC1=CC=C(C=C1)C(=O)\\C=C\\C2=CC(=C(OC(C)(C)C(O)=O)C(=C2)C)C",5.477,3,0,7]
["S3722","Isavuconazole","c10","L3900-14","in 10mM DMSO","Fungal","Microbiology","Isavuconazole (BAL-4815, RO-0094815) is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis.",437.47,"241479-67-4",{"v":87,"d":"87.00"},198.87,"<1","N/A","http://selleckchem.com/products/isavuconazole.html","C22H17F2N5OS","free base","BAL-4815, RO-0094815","CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(O)(C[N]3C=NC=N3)C4=CC(=CC=C4F)F",3.904,3,0,6]
["S3723","Ramosetron Hydrochloride","d10","L3900-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Ramosetron Hydrochloride (YM-060) is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity.",{"v":315.8,"d":"315.80"},"132907-72-3",{"v":63,"d":"63.00"},199.49,{"v":63,"d":"63.00"},199.49,"http://selleckchem.com/products/ramosetron-hydrochloride.html","C17H17N3O.HCl","hydrochloride","YM-060","Cl.C[N]1C=C(C(=O)C2CCC3=C(C2)[NH]C=N3)C4=C1C=CC=C4",2.948,2,1,2]
["S3724","Velpatasvir","e10","L3900-14","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Velpatasvir (GS-5816,VEL) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial \"membranous web\" that facilitates RNA replication.",{"v":883,"d":"883.00"},"1377049-84-7",{"v":100,"d":"100.00"},113.25,{"v":100,"d":"100.00"},113.25,"http://selleckchem.com/products/velpatasvir.html","C49H54N8O8","free base","GS-5816,VEL","COCC1CC(N(C1)C(=O)C(NC(=O)OC)C2=CC=CC=C2)C3=NC=C([NH]3)C4=CC=C5C(=C4)COC6=C5C=C7C=CC8=C(N=C([NH]8)C9CCC(C)N9C(=O)C(NC(=O)OC)C(C)C)C7=C6",5.789,10,4,13]
["S3726","Selexipag","f10","L3900-14","in 10mM DMSO","Prostaglandin Receptor","Immunology & Inflammation","Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).",496.62,"475086-01-2",{"v":99,"d":"99.00"},199.35,"<1","N/A","http://selleckchem.com/products/selexipag.html","C26H32N4O4S","free base","NS-304, ACT-293987","CC(C)N(CCCCOCC(=O)N[S](C)(=O)=O)C1=NC(=C(N=C1)C2=CC=CC=C2)C3=CC=CC=C3",3.996,6,1,12]
["S3727","Vilanterol Trifenate","g10","L3900-14","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.",774.77,"503070-58-4",{"v":100,"d":"100.00"},129.07,"<1","N/A","http://selleckchem.com/products/vilanterol-trifenate.html","C24H33Cl2NO5.C20H16O2","trifenatate","GW642444M Trifenate","OCC1=CC(=CC=C1O)C(O)CNCCCCCCOCCOCC2=C(Cl)C=CC=C2Cl.OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5",5.949,3,4,20]
["S3728","Grazoprevir","h10","L3900-14","in 10mM DMSO","HCV Protease","Proteases","Grazoprevir anhydrous (MK5172) is a Hepatitis C Virus NS3/4A Protease inhibitor with IC50 values of 7pM, 4pM, and 62pM for HCV genotype 1a, 1B, and 4 respectively.",{"v":766.9,"d":"766.90"},"1350514-68-9",{"v":100,"d":"100.00"},{"v":130.4,"d":"130.40"},"<1","N/A","http://selleckchem.com/products/grazoprevir.html","C38H50N6O9S","free base","MK5172","COC1=CC2=NC3=C(CCCCCC4CC4OC(=O)NC(C(=O)N5CC(CC5C(=O)NC6(CC6C=C)C(=O)N[S](=O)(=O)C7CC7)O3)C(C)(C)C)N=C2C=C1",3.975,11,3,8]
["S3729","Iron sucrose","a11","L3900-14","in 10mM DMSO","Others","Others","Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.",736.06,"8047-67-4",{"v":100,"d":"100.00"},135.86,{"v":100,"d":"100.00"},135.86,"http://selleckchem.com/products/iron-sucrose.html","C18H24Fe2O24","Iron saccharate","Iron saccharate, Sucroferric oxyhydroxide","[Fe+3].[Fe+3].OC(C(O)C(O)C([O-])=O)C(O)C([O-])=O.OC(C(O)C(O)C([O-])=O)C(O)C([O-])=O.OC(C(O)C(O)C([O-])=O)C(O)C([O-])=O",-16.899,0,12,15]
["S3730","Metaxalone","b11","L3900-14","in 10mM DMSO","Others","Others","Metaxalone (Skelaxin, Methaxalonum, Zorane) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.",221.25,"1665-48-1",{"v":44,"d":"44.00"},198.87,"<1","N/A","http://selleckchem.com/products/metaxalone.html","C12H15NO3","free base","Skelaxin, Methaxalonum, Zorane","CC1=CC(=CC(=C1)C)OCC2CNC(=O)O2",2.468,3,1,3]
["S3732","Avibactam sodium","c11","L3900-14","in 10mM DMSO","β-lactamase","Microbiology","Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.",287.23,"1192491-61-4",{"v":57,"d":"57.00"},198.45,{"v":57,"d":"57.00"},198.45,"http://selleckchem.com/products/avibactam-sodium.html","C7H10N3O6.Na","sodium salt","AVE-1330A, NXL104","[Na+].NC(=O)C1CCC2CN1C(=O)N2O[S]([O-])(=O)=O",-3.785,3,1,3]
["S3733","Boceprevir","d11","L3900-14","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Boceprevir (EBP 520, SCH 503034) is an oral, direct acting hepatitis C virus (HCV) protease inhibitor with Ki value of 14 nM for NS3. It is used in combination with other antiviral agents in the treatment of chronic hepatitis C, genotype 1.",519.68,"394730-60-0",{"v":100,"d":"100.00"},192.43,"<1","N/A","http://selleckchem.com/products/boceprevir.html","C27H45N5O5","free base","EBP 520, SCH 503034","CC(C)(C)NC(=O)NC(C(=O)N1CC2C(C1C(=O)NC(CC3CCC3)C(=O)C(N)=O)C2(C)C)C(C)(C)C",1.623,5,4,10]
["S3735","Umeclidinium bromide","e11","L3900-14","in 10mM DMSO","AChR","Neuronal Signaling","Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).",508.49,"869113-09-7",{"v":100,"d":"100.00"},196.66,"<1","N/A","http://selleckchem.com/products/umeclidinium-bromide.html","C29H34NO2.Br","bromide","GSK573719A","[Br-].OC(C1=CC=CC=C1)(C2=CC=CC=C2)C34CC[N+](CCOCC5=CC=CC=C5)(CC3)CC4",0.924,1,0,8]
["S3738","Travoprost","f11","L3900-14","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Travoprost (Travoprostum) is a PGF2a analog that was launched as an ophthalmic solution administered topically for the treatment of elevated intraocular hypertension as a result of open-angle glaucoma, a common optic neuropathy, and a leading cause of blindness. It can act as an agonist of prostaglandin F receptor.",500.55,"157283-68-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/travoprost.html","C26H35F3O6","free base","Travoprostum","CC(C)OC(=O)CCC\\C=C/CC1C(O)CC(O)C1\\C=C\\C(O)COC2=CC(=CC=C2)C(F)(F)F",4.269,3,3,14]
["S3739","Calcipotriene","g11","L3900-14","in 10mM DMSO","Vitamin","Metabolism","Calcipotriene (Calcipotriol, MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth.  Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.",{"v":412.6,"d":"412.60"},"112965-21-6",{"v":82,"d":"82.00"},198.74,"<1","N/A","http://selleckchem.com/products/calcipotriene.html","C27H40O3","free base","Calcipotriol, MC903","CC(\\C=C\\C(O)C1CC1)C2CCC3/C(CCCC23C)=C/C=C\\4CC(O)CC(O)C4=C",4.679,0,3,5]
["S3741","Benznidazole","h11","L3900-14","in 10mM DMSO","Parasite","Microbiology","Benznidazole (Radanil) is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis.",260.25,"22994-85-0",{"v":52,"d":"52.00"},199.81,"<1","N/A","http://selleckchem.com/products/benznidazole.html","C12H12N4O3","free base","Radanil","[O-][N+](=O)C1=NC=C[N]1CC(=O)NCC2=CC=CC=C2",1.002,2,1,5]
["S3742","Cholic acid","a2","L3900-15","in 10mM DMSO","Others","Metabolism","Cholic acid is a naturally occurring bile acid that is insoluble in water and is used to treat patients with genetic deficiencies in the synthesis of bile acids.",408.57,"81-25-4",{"v":81,"d":"81.00"},198.25,"<1","N/A","http://selleckchem.com/products/cholic-acid.html","C24H40O5","free base","N/A","CC(CCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",2.912,1,3,4]
["S3745","Balsalazide disodium","b2","L3900-15","in 10mM DMSO","Immunology & Inflammation related,Interleukins,STAT","Immunology & Inflammation","Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.",437.31,"150399-21-6",{"v":87,"d":"87.00"},198.94,{"v":87,"d":"87.00"},198.94,"http://selleckchem.com/products/balsalazide-disodium.html","C17H13N3O6.2H2O.2Na","disodium salt dihydrate","N/A","O.O.[Na+].[Na+].OC1=CC=C(C=C1C([O-])=O)N=NC2=CC=C(C=C2)C(=O)NCCC([O-])=O",-0.838,3,2,7]
["S3746","Lumefantrine","c2","L3900-15","in 10mM DMSO","Anti-infection","Microbiology","Lumefantrine (benflumetol) is an antimalarial agent used to treat acute uncomplicated malaria.",528.94,"82186-77-4",{"v":13,"d":"13.00"},24.58,"<1","N/A","http://selleckchem.com/products/lumefantrine.html","C30H32Cl3NO","free base","benflumetol","CCCCN(CCCC)CC(O)C1=CC(=CC\\2=C1C3=C(C=C(Cl)C=C3)C2=C/C4=CC=C(Cl)C=C4)Cl",9.196,0,1,10]
["S3747","Levothyroxine sodium","d2","L3900-15","in 10mM DMSO","THR","Metabolism","Levothyroxine (L-T4, L-Thyroxine) is the major hormone derived from the thyroid gland. It is the agonist of Thyroid hormone receptor alpha and beta.",798.85,"55-03-8",{"v":100,"d":"100.00"},125.18,"<1","N/A","http://selleckchem.com/products/levothyroxine-sodium.html","C15H10I4NO4.Na","sodium salt","L-T4 sodium, L-Thyroxine sodium, LT4 sodium","[Na+].NC(CC1=CC(=C(OC2=CC(=C(O)C(=C2)I)I)C(=C1)I)I)C([O-])=O",3.031,1,2,5]
["S3750","Sodium benzoate","e2","L3900-15","in 10mM DMSO","Others","Others","Sodium benzoate (Benzoic acid sodium salt) is a preservative and uesd as a food additive which is bacteriostatic and fungistatic under acidic conditions.",{"v":144.1,"d":"144.10"},"532-32-1",{"v":3,"d":"3.00"},20.82,{"v":28,"d":"28.00"},194.31,"http://selleckchem.com/products/sodium-benzoate.html","C7H5O2.Na","sodium salt","Benzoic acid sodium salt","[Na+].[O-]C(=O)C1=CC=CC=C1",-0.015,0,0,1]
["S3751","Quinidine hemisulfate hydrate","f2","L3900-15","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.",391.47,"6591-63-5",{"v":100,"d":"100.00"},154.12,{"v":9,"d":"9.00"},13.87,"http://selleckchem.com/products/quinidine-sulfate.html","C20H24N2O2.1/2H2SO4.H2O","hemisulfate hydrate","Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium","O.O.COC1=CC2=C(C=C1)N=CC=C2C(O)C3CC4CCN3CC4C=C.COC5=CC6=C(C=C5)N=CC=C6C(O)C7CC8CCN7CC8C=C.O[S](O)(=O)=O",4.446,4,2,8]
["S3756","Methyl salicylate","g2","L3900-15","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.",152.15,"119-36-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/methyl-salicylate.html","C8H8O3","free base","2-Carbomethoxyphenol, Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil","COC(=O)C1=C(O)C=CC=C1",1.443,2,1,2]
["S3758","Sinomenine hydrochloride","h2","L3900-15","in 10mM DMSO","Autophagy,Immunology & Inflammation related","Immunology & Inflammation","Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.",365.85,"6080-33-7",{"v":73,"d":"73.00"},199.54,"N/A","N/A","http://selleckchem.com/products/sinomenine-hydrochloride.html","C19H23NO4.HCl","hydrochloride","Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride","Cl.COC1=C(O)C2=C(CC3C4C=C(OC)C(=O)CC24CCN3C)C=C1",2.056,3,1,2]
["S3759","Norcantharidin","a3","L3900-15","in 10mM DMSO","c-Met,EGFR","Protein Tyrosine Kinase","Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.",168.15,"29745-04-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/norcantharidin.html","C8H8O4","free base","Endothall anhydride","O=C1OC(=O)C2C3CCC(O3)C12",-0.117,4,0,0]
["S3765","Picroside II","b3","L3900-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.",512.46,"39012-20-9",{"v":100,"d":"100.00"},195.14,"N/A","N/A","http://selleckchem.com/products/picroside-ii.html","C23H28O13","free base","6-Vanilloylcatalpol, Vanilloyl catalpol","COC1=CC(=CC=C1O)C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C5(CO)OC25",-1.796,7,6,8]
["S3772","5-Hydroxymethylfurfural","c3","L3900-15","in 10mM DMSO","Others","Others","5-Hydroxymethylfurfural (5-HMF) is an important bio-sourced intermediate, formed from carbohydrates such as glucose or fructose and used for production of fuels and chemical intermediates.",126.11,"67-47-0",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/5-hydroxymethylfurfural.html","C6H6O3","free base","N/A","OCC1=CC=C(O1)C=O",0.458,2,1,2]
["S3775","Ligustrazine hydrochloride","d3","L3900-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.",172.66,"76494-51-4",{"v":34,"d":"34.00"},196.92,"N/A","N/A","http://selleckchem.com/products/ligustrazine-hydrochloride.html","C8H12N2.HCl","hydrochloride","Tetramethylpyrazine HCl, Tetrapyrazine HCl","Cl.CC1=NC(=C(C)N=C1C)C",1.041,2,0,0]
["S3777","Gentiopicroside","e3","L3900-15","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Gentiopicroside (GE, Gentiopicrin), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and  dose not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities.",356.32,"20831-76-9",{"v":71,"d":"71.00"},199.26,"N/A","N/A","http://selleckchem.com/products/gentiopicroside.html","C16H20O9","free base","Gentiopicrin","OCC1OC(OC2OC=C3C(=O)OCC=C3C2C=C)C(O)C(O)C1O",-1.523,5,4,4]
["S3780","Secoisolariciresinol diglucoside","f3","L3900-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.",{"v":686.7,"d":"686.70"},"148244-82-0",{"v":100,"d":"100.00"},145.62,{"v":100,"d":"100.00"},145.62,"http://selleckchem.com/products/secoisolariciresinol-diglucoside.html","C32H46O16","free base","N/A","COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC",-0.651,6,10,15]
["S3787","Picroside I","g3","L3900-15","in 10mM DMSO","Anti-infection","Microbiology","Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.",492.47,"27409-30-9",{"v":98,"d":"98.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/picroside-i.html","C24H28O11","free base","6'-Cinnamoylcatalpol","OCC12OC1C(O)C3C=COC(OC4OC(COC(=O)\\C=C\\C5=CC=CC=C5)C(O)C(O)C4O)C23",{"v":-1.07,"d":"-1.070"},6,5,8]
["S3788","Carvacrol","h3","L3900-15","in 10mM DMSO","AChR","Neuronal Signaling","Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.",150.22,"499-75-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carvacrol.html","C10H14O","free base","cymophenol","CC(C)C1=CC=C(C)C(=C1)O",3.268,0,1,1]
["S3791","Succinic acid","a4","L3900-15","in 10mM DMSO","Others","Metabolism","Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.",118.09,"110-15-6",{"v":23,"d":"23.00"},194.77,"N/A","N/A","http://selleckchem.com/products/succinic-acid.html","C4H6O4","free base","1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid","OC(=O)CCC(O)=O",{"v":-0.36,"d":"-0.360"},2,0,3]
["S3796","Rebaudioside A","b4","L3900-15","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.",967.01,"58543-16-1",{"v":40,"d":"40.00"},41.36,"N/A","N/A","http://selleckchem.com/products/rebaudioside-a.html","C44H70O23","free base","Reb A, Glycoside A3, Stevioside A3","CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(OC6OC(CO)C(O)C(O)C6O)C5OC7OC(CO)C(O)C(O)C7O)C(=O)OC8OC(CO)C(O)C(O)C8O",-3.476,9,14,13]
["S3797","Helicide","c4","L3900-15","in 10mM DMSO","Others","Others","Helicide (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia.",284.26,"80154-34-3",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"N/A","N/A","http://selleckchem.com/products/helicide.html","C13H16O7","free base","4-formylphenyl-O-β-d-allopyranoside","OCC1OC(OC2=CC=C(C=O)C=C2)C(O)C(O)C1O",-0.583,3,4,4]
["S3804","Alpha-Mangostin","d4","L3900-15","in 10mM DMSO","Dehydrogenase,STING","Metabolism","Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities.    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.",410.46,"6147-11-1",{"v":82,"d":"82.00"},199.78,"N/A","N/A","http://selleckchem.com/products/alpha-mangostin.html","C24H26O6","free base","N/A","COC1=C(O)C=C2OC3=C(C(=C(CC=C(C)C)C(=C3)O)O)C(=O)C2=C1CC=C(C)C",5.935,3,3,5]
["S3805","Stevioside","e4","L3900-15","in 10mM DMSO","Others","Others","Stevioside is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni.",804.87,"57817-89-7",{"v":100,"d":"100.00"},124.24,"N/A","N/A","http://selleckchem.com/products/stevioside.html","C38H60O18","free base","N/A","CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O",-1.729,7,11,10]
["S3811","Ginsenoside Re","f4","L3900-15","in 10mM DMSO","Beta Amyloid,JNK,NF-κB","Neuronal Signaling","Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.",947.15,"52286-59-6",{"v":100,"d":"100.00"},105.58,"N/A","N/A","http://selleckchem.com/products/ginsenoside-re.html","C48H82O18","free base","Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc","CC1OC(OC2C(O)C(O)C(CO)OC2OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C1O",0.267,6,12,12]
["S3813","Bakuchiol","g4","L3900-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.",256.38,"10309-37-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/bakuchiol.html","C18H24O","free base","(S)-(+)-Bakuchiol","CC(C)=CCCC(C)(C=C)\\C=C\\C1=CC=C(O)C=C1",5.348,0,1,6]
["S3817","Harmine hydrochloride","h4","L3900-15","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,DYRK,MAO","Cell Cycle","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",248.71,"343-27-1",{"v":21,"d":"21.00"},84.44,"N/A","N/A","http://selleckchem.com/products/harmine-hydrochloride.html","C13H12N2O.HCl","hydrochloride","Telepathine hydrochloride","Cl.COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",{"v":2.82,"d":"2.820"},2,1,1]
["S3826","Hydroxytyrosol","a5","L3900-15","in 10mM DMSO","Others","Others","Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities.",154.16,"10597-60-1",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol.html","C8H10O3","free base","3-Hydroxytyrosol; 3,4-dihydroxyphenylethanol; Dihydroxyphenylethanol; 2-(3,4-Di-hydroxyphenyl)-ethanol","OCCC1=CC=C(O)C(=C1)O",1.062,0,3,2]
["S3834","Astaxanthin","b5","L3900-15","in 10mM DMSO","PPAR","Metabolism","Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.",596.84,"472-61-7",{"v":100,"d":"100.00"},167.55,"N/A","N/A","http://selleckchem.com/products/astaxanthin.html","C40H52O4","free base","β-Carotene-4,4'-dione, Trans-Astaxanthin","CC(=C\\C=C\\C=C(C)\\C=C\\C=C(C)\\C=C\\C1=C(C)C(=O)C(O)CC1(C)C)/C=C/C=C(C)/C=C/C2=C(C)C(=O)C(O)CC2(C)C",8.421,2,2,10]
["S3839","1-Deoxynojirimycin","c5","L3900-15","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.",163.17,"19130-96-2",{"v":16,"d":"16.00"},98.06,"N/A","N/A","http://selleckchem.com/products/1-deoxynojirimycin.html","C6H13NO4","free base","duvoglustat, moranolin","OCC1NCC(O)C(O)C1O",{"v":-2.44,"d":"-2.440"},0,5,1]
["S3842","Isoquercitrin","d5","L3900-15","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.",464.38,"482-35-9",{"v":92,"d":"92.00"},198.11,"N/A","N/A","http://selleckchem.com/products/isoquercitrin.html","C21H20O12","free base","Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside","OCC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S3846","Eupatilin","e5","L3900-15","in 10mM DMSO","PPAR","Metabolism","Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.",344.32,"22368-21-4",{"v":68,"d":"68.00"},197.49,"N/A","N/A","http://selleckchem.com/products/eupatilin.html","C18H16O7","free base","NSC 122413","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)OC",2.603,5,2,4]
["S3849","D-Galactose","f5","L3900-15","in 10mM DMSO","Others","Others","D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.",180.16,"59-23-4",{"v":36,"d":"36.00"},199.82,"N/A","N/A","http://selleckchem.com/products/d-galactose.html","C6H12O6","free base","D-Galactopyranose, D-(+)-Galactose","OCC1OC(O)C(O)C(O)C1O",-2.514,1,4,1]
["S3850","Glucosamine sulfate","g5","L3900-15","in 10mM DMSO","Others","Others","Glucosamine sulfate (D-Glucosaminesulfate, D-Glucosamine sulphate) is a dietary supplement commonly used in the treatment of osteoarthritis. It is a type of glycosaminoglycan, which is a naturally occurring major component of joint cartilage and joint fluid.",277.25,"29031-19-4",{"v":4,"d":"4.00"},14.43,{"v":55,"d":"55.00"},198.38,"http://selleckchem.com/products/glucosamine-sulfate.html","C6H13NO5.H2SO4","sulfate","D-Glucosaminesulfate, D-Glucosamine sulphate","NC(C=O)C(O)C(O)C(O)CO.O[S](O)(=O)=O",-3.688,1,5,5]
["S3851","Camphor","h5","L3900-15","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.",152.23,"76-22-2",{"v":30,"d":"30.00"},197.07,"N/A","N/A","http://selleckchem.com/products/camphor.html","C10H16O","free base","2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa","CC1(C)C2CCC1(C)C(=O)C2",2.075,1,0,0]
["S3853","Perillyl alcohol","a6","L3900-15","in 10mM DMSO","Ras","Apoptosis","Perillyl alcohol (Perilla alcohol, Isocarveol) is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants.",152.23,"536-59-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/perillyl-alcohol.html","C10H16O","free base","Perilla alcohol, Isocarveol","CC(=C)C1CCC(=CC1)CO",2.411,0,1,2]
["S3856","Allantoin","b6","L3900-15","in 10mM DMSO","Others","Others","Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.",158.12,"97-59-6",{"v":7,"d":"7.00"},44.27,"N/A","N/A","http://selleckchem.com/products/allantoin.html","C4H6N4O3","free base","Glyoxyldiureide, 5-Ureidohydantoin","NC(=O)NC1NC(=O)NC1=O",{"v":-1.76,"d":"-1.760"},3,4,1]
["S3860","Allicin","c6","L3900-15","in 10mM DMSO","Fungal","Metabolism","Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.",162.27,"539-86-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/allicin.html","C6H10OS2","free base","diallyl thiosulfinate","C=CCS[S](=O)CC=C",2.005,1,0,5]
["S3866","Galanthamine","d6","L3900-15","in 10mM DMSO","AChR","Neuronal Signaling","Galanthamine (Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase. It is studied as a treatment for Alzheimer's disease and other central nervous system disorders.",287.35,"357-70-0",{"v":100,"d":"100.00"},348.01,{"v":57,"d":"57.00"},198.36,"http://selleckchem.com/products/galanthamine.html","C17H21NO3","free base","Galantamine, Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine","COC1=C2OC3CC(O)C=CC34CCN(C)CC(=C24)C=C1",1.442,2,1,1]
["S3868","Harmine","e6","L3900-15","in 10mM DMSO","MAO,PPAR","Metabolism","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",212.25,"442-51-3",{"v":42,"d":"42.00"},197.88,"N/A","N/A","http://selleckchem.com/products/harmine.html","C13H12N2O","free base","Telepathine","COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",2.438,2,1,1]
["S3870","D-Pinitol","f6","L3900-15","in 10mM DMSO","Influenza Virus","Microbiology","D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.",194.18,"10284-63-6",{"v":38,"d":"38.00"},195.69,"N/A","N/A","http://selleckchem.com/products/d-pinitol.html","C7H14O6","free base","Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol","COC1C(O)C(O)C(O)C(O)C1O",-2.656,1,5,1]
["S3872","Guaiacol","g6","L3900-15","in 10mM DMSO","COX,NF-κB","NF-κB","Guaiacol (O-methoxyphenol, 2-hydroxyanisole, O-methylcatechol) is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin. Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity.",124.14,"90-05-1",{"v":24,"d":"24.00"},193.33,"N/A","N/A","http://selleckchem.com/products/guaiacol.html","C7H8O2","free base","o-methoxyphenol, 2-hydroxyanisole, O-methylcatechol","COC1=C(O)C=CC=C1",1.571,1,1,1]
["S3876","Indigo","h6","L3900-15","in 10mM DMSO","Dyes","Others","Indigo (Indigotin) dye is an organic compound with a distinctive blue color. It is extracted from the leaves of certain plants or synthetic.",262.26,"482-89-3",{"v":33,"d":"33.00"},125.83,"N/A","N/A","http://selleckchem.com/products/indigo.html","C16H10N2O2","free base","Indigotin","O=C1\\C(NC2=C1C=CC=C2)=C\\3NC4=C(C=CC=C4)C3=O",2.106,2,2,0]
["S3889","Arteether","a7","L3900-15","in 10mM DMSO","Parasite","Microbiology","Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.",{"v":312.4,"d":"312.40"},"75887-54-6",{"v":62,"d":"62.00"},198.46,"N/A","N/A","http://selleckchem.com/products/arteether.html","C17H28O5","free base","N/A","CCOC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3",2.378,5,0,2]
["S3897","(-)-Arctigenin","b7","L3900-15","in 10mM DMSO","Influenza Virus","Microbiology","(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.",372.41,"7770-78-7",{"v":74,"d":"74.00"},198.71,"N/A","N/A","http://selleckchem.com/products/neg-rotation-arctigenin.html","C21H24O6","free base","N/A","COC1=C(O)C=CC(=C1)CC2C(COC2=O)CC3=CC=C(OC)C(=C3)OC",3.743,5,1,7]
["S3905","Iso-Steviol","c7","L3900-15","in 10mM DMSO","Others","Others","Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects.",318.45,"27975-19-5",{"v":63,"d":"63.00"},197.83,"N/A","N/A","http://selleckchem.com/products/iso-steviol.html","C20H30O3","free base","N/A","CC12CCC3C4(C)CCCC(C)(C4CCC3(CC1=O)C2)C(O)=O",3.924,2,0,1]
["S3922","(-)-epigallocatechin","d7","L3900-15","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.",306.27,"970-74-1",{"v":61,"d":"61.00"},199.17,"N/A","N/A","http://selleckchem.com/products/neg-rotation-epigallocatechin.html","C15H14O7","free base","N/A","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S3925","(-)-Epicatechin gallate","e7","L3900-15","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,"N/A","N/A","http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3931","Ginsenoside Rd","f7","L3900-15","in 10mM DMSO","Calcium Channel,COX,NF-κB,NOS,P450 (e.g. CYP17)","Immunology & Inflammation","Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.",947.15,"52705-93-8",{"v":90,"d":"90.00"},95.02,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rd.html","C48H82O18","free base","Panaxoside Rd, Sanchinoside Rd","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C(C)(C)C5CCC34C",0.548,6,12,13]
["S3934","Acetyl Resveratrol","g7","L3900-15","in 10mM DMSO","Others","Others","Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.",354.35,"42206-94-0",{"v":70,"d":"70.00"},197.54,"<1","N/A","https://www.selleckchem.com/products/acetyl-resveratrol.html","C20H18O6","free base","N/A","CC(=O)OC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC(C)=O)OC(C)=O",3.119,6,0,8]
["S3937","Pterostilbene","h7","L3900-15","in 10mM DMSO","Others","Others","Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.",{"v":256.3,"d":"256.30"},"537-42-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/pterostilbene.html","C16H16O3","free base","N/A","COC1=CC(=CC(=C1)\\C=C\\C2=CC=C(O)C=C2)OC",3.541,2,1,4]
["S3941","Pinocembrin","a8","L3900-15","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.",256.25,"480-39-7",{"v":51,"d":"51.00"},199.02,"<1","N/A","http://selleckchem.com/products/pinocembrin.html","C15H12O4","free base","Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone","OC1=CC2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O",2.615,2,2,1]
["S3944","Valproic acid (VPA)","b8","L3900-15","in 10mM DMSO","Autophagy,HDAC,Mitophagy,Notch,PGC-1α","Epigenetics","Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.",144.21,"99-66-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/valproic-acid.html","C8H16O2","free base","2-Propylvaleric Acid, Valproate","CCCC(CCC)C(O)=O",2.749,1,0,5]
["S3945","L-Cycloserine","c8","L3900-15","in 10mM DMSO","Transferase","Metabolism","L-Cycloserine (Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.",102.09,"339-72-0",{"v":8,"d":"8.00"},78.36,{"v":20,"d":"20.00"},195.91,"http://selleckchem.com/products/l-cycloserine.html","C3H6N2O2","free base","Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine","NC1CONC1=O",-1.788,2,2,0]
["S3951","Tannic acid","d8","L3900-15","in 10mM DMSO","CXCR","Immunology & Inflammation","Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.",{"v":1701.2,"d":"1701.20"},"1401-55-4",{"v":100,"d":"100.00"},58.78,"N/A","N/A","http://selleckchem.com/products/tannic-acid.html","C76H52O46","free base","Gallotannic acid","OC1=CC(=CC(=C1O)O)C(=O)OC2=C(O)C(=CC(=C2)C(=O)OCC3OC(OC(=O)C4=CC(=C(O)C(=C4)O)OC(=O)C5=CC(=C(O)C(=C5)O)O)C(OC(=O)C6=CC(=C(O)C(=C6)O)OC(=O)C7=CC(=C(O)C(=C7)O)O)C(OC(=O)C8=CC(=C(O)C(=C8)O)OC(=O)C9=CC(=C(O)C(=C9)O)O)C3OC(=O)C%10=CC(=C(O)C(=C%10)O)OC(=O)C%11=CC(=C(O)C(=C%11)O)O)O",8.813,21,25,31]
["S3959","(+)-Borneol","e8","L3900-15","in 10mM DMSO","GABA Receptor","Neuronal Signaling","(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.",154.25,"464-43-7",{"v":30,"d":"30.00"},194.49,"N/A","N/A","http://selleckchem.com/products/positive-rotation-borneol.html","C10H18O","free base","N/A","CC1(C)C2CCC1(C)C(O)C2",1.975,0,1,0]
["S3960","Higenamine hydrochloride","f8","L3900-15","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.",307.77,"11041-94-4",{"v":61,"d":"61.00"},{"v":198.2,"d":"198.20"},"N/A","N/A","http://selleckchem.com/products/higenamine-hydrochloride.html","C16H17NO3.HCl","hydrochloride","Norcoclaurine HCl, (+-)-Demethylcoclaurine hydrochloride","Cl.OC1=CC=C(CC2NCCC3=CC(=C(O)C=C23)O)C=C1",3.031,0,4,2]
["S3967","Flavone","g8","L3900-15","in 10mM DMSO","Apoptosis related","Apoptosis","Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.",222.24,"525-82-6",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/flavone.html","C15H10O2","free base","2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron","O=C1C=C(OC2=C1C=CC=C2)C3=CC=CC=C3",3.136,2,0,1]
["S3968","Histamine","h8","L3900-15","in 10mM DMSO","Histamine Receptor","Immunology & Inflammation","Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist.",111.15,"51-45-6",{"v":22,"d":"22.00"},197.93,"N/A","N/A","http://selleckchem.com/products/histamine.html","C5H9N3","free base","N/A","NCCC1=C[NH]C=N1",-0.714,1,2,2]
["S3974","(+)-Catechin hydrate","a9","L3900-15","in 10mM DMSO","COX","Immunology & Inflammation","(+)-Catechin hydrate is a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.  (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.",290.27,"225937-10-0",{"v":58,"d":"58.00"},199.81,"N/A","N/A","http://selleckchem.com/products/catechin-hydrate.html","C15H14O6.xH2O","hydrate","N/A","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S3977","(-)-Borneol","b9","L3900-15","in 10mM DMSO","GABA Receptor","Neuronal Signaling","(-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odor. (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.",154.25,"464-45-9",{"v":30,"d":"30.00"},194.49,"N/A","N/A","http://selleckchem.com/products/l-borneol.html","C10H18O","free base","L-Borneol","CC1(C)C2CCC1(C)C(O)C2",1.975,0,1,0]
["S3980","Pyridoxine","c9","L3900-15","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.",169.18,"65-23-6",{"v":33,"d":"33.00"},195.06,"N/A","N/A","http://selleckchem.com/products/pyridoxine.html","C8H11NO3","free base","Pyridoxol, Vitamin B6, Gravidox","CC1=NC=C(CO)C(=C1O)CO",{"v":-0.49,"d":"-0.490"},1,3,2]
["S3984","Nordihydroguaiaretic acid (NDGA)","d9","L3900-15","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase","Metabolism","Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.",302.36,"500-38-9",{"v":60,"d":"60.00"},198.44,"<1","N/A","http://selleckchem.com/products/nordihydroguaiaretic-acid.html","C18H22O4","free base","N/A","CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O",4.708,0,4,5]
["S3992","D-(+)-Trehalose dihydrate","e9","L3900-15","in 10mM DMSO","Others","Others","Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.",378.33,"6138-23-4",{"v":75,"d":"75.00"},198.24,"N/A","N/A","http://selleckchem.com/products/d-trehalose-dihyd.html","C12H22O11.2H2O","dihydrate","N/A","O.O.OCC1OC(OC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O",-4.675,3,8,4]
["S3996","Thioctic acid","f9","L3900-15","in 10mM DMSO","Others","Others","Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form., Thioctic acid (DL-α-Lipoic acid)是环状二硫抗氧化剂，可与其还原性二硫酚形式相互转换。",206.33,"1077-28-7",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/thioctic-acid.html","C8H14O2S2","free base","DL-α-Lipoic Acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S3998","(+)-α-Lipoic acid","g9","L3900-15","in 10mM DMSO","LTR,NF-κB","NF-κB","(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.",206.33,"1200-22-2",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/alpha-lipoic-acid.html","C8H14O2S2","free base","(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S4000","Pergolide Mesylate","h9","L3900-15","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.",410.59,"66104-23-2",{"v":10,"d":"10.00"},24.36,{"v":82,"d":"82.00"},199.71,"http://selleckchem.com/products/Pergolide-mesylate.html","C20H30N2O3S2","Mesylate","LY127809","CCCN1CC(CSC)CC2C1CC3=C[NH]C4=C3C2=CC=C4.C[S](O)(=O)=O",3.696,0,1,4]
["S4001","Cabozantinib malate","a10","L3900-15","in 10mM DMSO","Apoptosis related,Axl,c-Kit,c-Met,c-RET,FLT3,VEGFR","Protein Tyrosine Kinase","Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis.",635.59,"1140909-48-3",{"v":100,"d":"100.00"},157.33,"<1","N/A","http://selleckchem.com/products/cabozantinib-malate.html","C28H24FN3O5.C4H6O5","Malate","XL184","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3.OC(CC(O)=O)C(O)=O",3.331,8,3,11]
["S4002","Sitagliptin phosphate monohydrate","b10","L3900-15","in 10mM DMSO","DPP","Metabolism","Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.",523.32,"654671-77-9",{"v":100,"d":"100.00"},191.09,{"v":41,"d":"41.00"},78.35,"https://www.selleckchem.com/products/sitagliptin-phosphate-monohydrate.html","C16H15F6N5O.H3PO4.H2O","phosphate &monohydrate","MK-0431","O.NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F.O[P](O)(O)=O",1.254,3,1,5]
["S4003","Lithocholic acid","c10","L3900-15","in 10mM DMSO","FXR","Metabolism","Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.",376.57,"434-13-9",{"v":75,"d":"75.00"},199.17,"<1","N/A","http://selleckchem.com/products/lithocholic-acid.html","C24H40O3","free base","N/A","CC(CCC(O)=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C",5.184,1,1,4]
["S4004","Ethambutol 2HCl","d10","L3900-15","in 10mM DMSO","Bacterial","Microbiology","Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.",277.23,"1070-11-7",{"v":56,"d":"56.00"},{"v":202,"d":"202.00"},{"v":56,"d":"56.00"},{"v":202,"d":"202.00"},"http://selleckchem.com/products/ethambutol-hcl.html","C10H24N2O2.2HCl","Dihydrochloride","CL40881","Cl.Cl.CCC(CO)NCCNC(CC)CO",0.874,0,4,9]
["S4007","Pentamidine isethionate","e10","L3900-15","in 10mM DMSO","phosphatase","Metabolism","Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.",592.68,"140-64-7",{"v":100,"d":"100.00"},168.73,{"v":100,"d":"100.00"},168.73,"http://selleckchem.com/products/pentamidine-isethionate.html","C19H24N4O2.2C2H6O4S","isethionate","N/A","NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1.OCC[S](O)(=O)=O.OCC[S](O)(=O)=O",0.751,2,4,14]
["S4009","Mirabegron","f10","L3900-15","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.",396.51,"223673-61-8",{"v":79,"d":"79.00"},199.24,"<1","N/A","http://selleckchem.com/products/mirabegron-ym178.html","C21H24N4O2S","free base","YM 178","NC1=NC(=CS1)CC(=O)NC2=CC=C(CCNCC(O)C3=CC=CC=C3)C=C2",{"v":2.26,"d":"2.260"},2,4,9]
["S4011","Ampiroxicam","g10","L3900-15","in 10mM DMSO","COX","Neuronal Signaling","Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.",447.46,"99464-64-9",{"v":90,"d":"90.00"},201.14,"<1","N/A","http://selleckchem.com/products/ampiroxicam.html","C20H21N3O7S","free base","CP 65703","CCOC(=O)OC(C)OC1=C(N(C)[S](=O)(=O)C2=C1C=CC=C2)C(=O)NC3=NC=CC=C3",1.718,8,1,8]
["S4012","Desloratadine","h10","L3900-15","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Desloratadine (SCH-34117, NSC 675447) is a potent antagonist for  human histamine H1 receptor with IC50 of 51 nM.",310.82,"100643-71-8",{"v":26,"d":"26.00"},83.65,"<1","N/A","http://selleckchem.com/products/desloratadine.html","C19H19ClN2","free base","SCH-34117, NSC 675447","ClC1=CC2=C(C=C1)C(=C3CCNCC3)C4=C(CC2)C=CC=N4",4.213,1,1,0]
["S4014","Hyoscyamine","a11","L3900-15","in 10mM DMSO","AChR","Neuronal Signaling","Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.",289.37,"101-31-5",{"v":58,"d":"58.00"},200.44,"<1","N/A","http://selleckchem.com/products/hyoscyamine-daturine.html","C17H23NO3","free base","Daturine","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",1.721,2,1,5]
["S4019","Avanafil","b11","L3900-15","in 10mM DMSO","PDE","Metabolism","Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.",483.95,"330784-47-9",{"v":97,"d":"97.00"},200.43,"<1","N/A","http://selleckchem.com/products/avanafil.html","C23H26ClN7O3","free base","N/A","COC1=C(Cl)C=C(CNC2=C(C=NC(=N2)N3CCCC3CO)C(=O)NCC4=NC=CC=N4)C=C1",2.165,6,3,9]
["S4020","Sodium Picosulfate","c11","L3900-15","in 10mM DMSO","Others","Others","Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.",481.41,"10040-45-6",{"v":96,"d":"96.00"},199.41,{"v":96,"d":"96.00"},199.41,"http://selleckchem.com/products/sodium-picosulfate.html","C18H15NO8S2.2Na","Sodium Salt","N/A","[Na+].[Na+].[O-][S](=O)(=O)OC1=CC=C(C=C1)C(C2=CC=C(O[S]([O-])(=O)=O)C=C2)C3=CC=CC=N3",-1.604,3,0,7]
["S4021","Tolcapone","d11","L3900-15","in 10mM DMSO","COMT,Histone Methyltransferase,Transferase","Metabolism","Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.",273.24,"134308-13-7",{"v":55,"d":"55.00"},201.29,"<1","N/A","http://selleckchem.com/products/tolcapone.html","C14H11NO5","free base","Ro 40-7592","CC1=CC=C(C=C1)C(=O)C2=CC(=C(O)C(=C2)[N+]([O-])=O)O",{"v":3.13,"d":"3.130"},1,2,3]
["S4022","Probenecid","e11","L3900-15","in 10mM DMSO","Taste Receptor,TRP Channel","Transmembrane Transporters","Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.",285.36,"57-66-9",{"v":57,"d":"57.00"},199.75,"<1","N/A","http://selleckchem.com/products/probenecid-benemid.html","C13H19NO4S","free base","Benemid","CCCN(CCC)[S](=O)(=O)C1=CC=C(C=C1)C(O)=O",2.321,3,0,7]
["S4023","Procaine HCl","f11","L3900-15","in 10mM DMSO","AChR,NMDAR,Sodium Channel","Transmembrane Transporters","Procaine (Novocaine) is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.",272.77,"51-05-8",{"v":55,"d":"55.00"},201.64,{"v":55,"d":"55.00"},201.64,"http://selleckchem.com/products/procaine-novocaine-hcl.html","C13H20N2O2.HCl","HCl","Novocaine HCl","Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1",2.157,2,1,7]
["S4024","Homatropine Methylbromide","g11","L3900-15","in 10mM DMSO","AChR","Neuronal Signaling","Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.",370.28,"80-49-9",{"v":74,"d":"74.00"},199.85,{"v":74,"d":"74.00"},199.85,"http://selleckchem.com/products/homatropine-methylbromide.html","C17H24NO3.Br","quaternary-N bromide salt","N/A","[Br-].C[N+]1(C)C2CCC1CC(C2)OC(=O)C(O)C3=CC=CC=C3",-2.076,2,1,4]
["S4025","Homatropine Bromide","h11","L3900-15","in 10mM DMSO","AChR","Neuronal Signaling","Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.",356.25,"51-56-9",{"v":71,"d":"71.00"},{"v":199.3,"d":"199.30"},{"v":71,"d":"71.00"},{"v":199.3,"d":"199.30"},"http://selleckchem.com/products/homatropine-bromide.html","C16H21NO3.HBr","quaternary-N bromide salt","N/A","Br.CN1C2CCC1CC(C2)OC(=O)C(O)C3=CC=CC=C3",2.188,2,1,4]
["S4026","Hydroxyzine 2HCl","a2","L3900-16","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.",447.83,"2192-20-3",{"v":90,"d":"90.00"},200.97,{"v":90,"d":"90.00"},200.97,"http://selleckchem.com/products/hydroxyzine-2hcl.html","C21H27ClN2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",4.231,1,1,8]
["S4031","Aclidinium Bromide","b2","L3900-16","in 10mM DMSO","AChR","Neuronal Signaling","Aclidinium Bromide (LAS 34273, LAS-W 330) inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.",564.55,"320345-99-1",{"v":113,"d":"113.00"},200.16,"<1","N/A","http://selleckchem.com/products/aclidinium-bromide.html","C26H30NO4S2.Br","quaternary-N bromide salt","LAS 34273, LAS-W 330","[Br-].OC(C(=O)OC1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)(C4=CC=CS4)C5=CC=CS5",0.979,3,0,10]
["S4037","Doxapram HCl","c2","L3900-16","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.",432.98,"7081-53-0",{"v":87,"d":"87.00"},200.93,{"v":25,"d":"25.00"},57.74,"http://selleckchem.com/products/doxapram-hcl.html","C24H30N2O2.HCl.H2O","HCl","N/A","O.Cl.CCN1CC(CCN2CCOCC2)C(C1=O)(C3=CC=CC=C3)C4=CC=CC=C4",3.218,2,0,6]
["S4039","Methazolamide","d2","L3900-16","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.",236.27,"554-57-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/methazolamide.html","C5H8N4O3S2","free base","CL 8490","CN1N=C(SC1=NC(C)=O)[S](N)(=O)=O",{"v":0.03,"d":"0.030"},5,1,1]
["S4040","Norethindrone","e2","L3900-16","in 10mM DMSO","Others,0","Others","Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.",298.42,"68-22-4",{"v":60,"d":"60.00"},201.06,"<1","N/A","http://selleckchem.com/products/norethindrone-norethisterone.html","C20H26O2","free base","Norethisterone","CC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.315,1,0,0]
["S4041","Olsalazine Sodium","f2","L3900-16","in 10mM DMSO","Anti-infection","Microbiology","Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.",{"v":346.2,"d":"346.20"},"6054-98-4",{"v":4,"d":"4.00"},11.55,{"v":41,"d":"41.00"},118.43,"http://selleckchem.com/products/olsalazine-sodium.html","C14H8N2O6.2Na","Disodium Salt","N/A","[Na+].[Na+].OC1=CC=C(C=C1C([O-])=O)N=NC2=CC=C(O)C(=C2)C([O-])=O",0.026,2,2,4]
["S4042","Nafcillin Sodium","g2","L3900-16","in 10mM DMSO","β-lactamase","Microbiology","Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.",454.47,"7177-50-6",{"v":91,"d":"91.00"},200.23,{"v":91,"d":"91.00"},200.23,"http://selleckchem.com/products/nafcillin-sodium.html","C21H21N2O5S.H2O.Na","sodium Salt","CL 8491","O.CCOC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C(=O)O[Na])C4=C(C=CC=C4)C=C1",2.213,5,1,6]
["S4045","Pheniramine Maleate","h2","L3900-16","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.",356.42,"132-20-7",{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},"http://selleckchem.com/products/pheniramine-maleate.html","C16H20N2.C4H4O4","Maleate","N/A","CN(C)CCC(C1=CC=CC=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",0.036,3,0,7]
["S4046","Estradiol Cypionate","a3","L3900-16","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor.",396.56,"313-06-4",{"v":79,"d":"79.00"},199.21,"<1","N/A","http://selleckchem.com/products/estradiol-cypionate.html","C26H36O3","free base","N/A","CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2OC(=O)CCC5CCCC5",6.589,2,1,5]
["S4047","Bisacodyl","b3","L3900-16","in 10mM DMSO","Others","Others","Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.",361.39,"603-50-9",{"v":72,"d":"72.00"},199.23,"<1","N/A","http://selleckchem.com/products/bisacodyl.html","C22H19NO4","free base","N/A","CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(OC(C)=O)C=C2)C3=CC=CC=N3",3.691,5,0,7]
["S4048","Carbimazole","c3","L3900-16","in 10mM DMSO","TSH Receptor","Endocrinology & Hormones","Carbimazole is an imidazole antithyroid agent.",186.23,"22232-54-8",{"v":38,"d":"38.00"},204.05,"<1","N/A","http://selleckchem.com/products/carbimazole.html","C7H10N2O2S","free base","N/A","CCOC(=O)N1C=CN(C)C1=S",1.202,2,0,2]
["S4049","Valdecoxib","d3","L3900-16","in 10mM DMSO","COX","Neuronal Signaling","Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.",314.36,"181695-72-7",{"v":63,"d":"63.00"},200.41,"<1","N/A","http://selleckchem.com/products/valdecoxib.html","C16H14N2O3S","free base","N/A","CC1=C(C2=CC=C(C=C2)[S](N)(=O)=O)C(=NO1)C3=CC=CC=C3",{"v":2.6,"d":"2.600"},4,1,3]
["S4050","Valganciclovir HCl","e3","L3900-16","in 10mM DMSO","CMV","Microbiology","Valganciclovir HCl is a prodrug for ganciclovir with antiviral activity used to treat cytomegalovirus infections.",390.82,"175865-59-5",{"v":78,"d":"78.00"},199.58,{"v":78,"d":"78.00"},199.58,"http://selleckchem.com/products/valganciclovir-hcl.html","C14H22N6O5.HCl","Hydrochloride","N/A","Cl.CC(C)C(N)C(=O)OCC(CO)OCN1C=NC2C1N=C(N)NC2=O",-1.444,6,4,9]
["S4051","Nabumetone","f3","L3900-16","in 10mM DMSO","COX","Neuronal Signaling","Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.",228.29,"42924-53-8",{"v":46,"d":"46.00"},{"v":201.5,"d":"201.50"},"<1","N/A","http://selleckchem.com/products/nabumetone.html","C15H16O2","free base","BRL-14777","COC1=CC=C2C=C(CCC(C)=O)C=CC2=C1",2.943,2,0,4]
["S4053","Sertraline HCl","g3","L3900-16","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Sertraline HCl (CP-51974-1) is a 5-HT antagonist with Ki of 13 nM.",342.69,"79559-97-0",{"v":69,"d":"69.00"},201.35,"<1","N/A","http://selleckchem.com/products/sertraline-hcl.html","C17H17Cl2N.HCl","HCl","CP-51974-1 HCl","Cl.CNC1CCC(C2=CC=C(Cl)C(=C2)Cl)C3=C1C=CC=C3",5.378,0,1,2]
["S4054","Spironolactone","h3","L3900-16","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.",416.57,"52-01-7",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/spironolactone.html","C24H32O4S","free base","N/A","CC(=O)SC1CC2=CC(=O)CCC2(C)C3CCC4(C)C(CCC45CCC(=O)O5)C13",3.731,4,0,2]
["S4056","Retapamulin","a4","L3900-16","in 10mM DMSO","Antibiotics","Microbiology","Retapamulin (SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.",517.76,"224452-66-8",{"v":104,"d":"104.00"},200.87,"<1","N/A","http://selleckchem.com/products/retapamulin.html","C30H47NO4S","free base","SB-275833","CC1CCC23CCC(=O)C2C1(C)C(CC(C)(C=C)C(O)C3C)OC(=O)CSC4CC5CCC(C4)N5C",4.154,3,1,6]
["S4058","Ropivacaine HCl","b4","L3900-16","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.",310.86,"98717-15-8",{"v":62,"d":"62.00"},199.45,{"v":46,"d":"46.00"},147.98,"http://selleckchem.com/products/ropivacaine-hcl.html","C17H26N2O.HCl","HCl","LEA-103 HCl","Cl.CCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.236,1,1,4]
["S4059","Sodium Nitroprusside Dihydrate","c4","L3900-16","in 10mM DMSO","Others","Others","Sodium Nitroprusside  Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.",297.95,"13755-38-9",{"v":60,"d":"60.00"},201.38,{"v":60,"d":"60.00"},201.38,"http://selleckchem.com/products/sodium-nitroprusside-dihydrate.html","C5H4FeN6Na2O3","Dihydrate","N/A","[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N",0.571,1,0,1]
["S4060","Erythromycin Ethylsuccinate","d4","L3900-16","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.",862.05,"1264-62-6",{"v":172,"d":"172.00"},199.52,"<1","N/A","http://selleckchem.com/products/erythromycin-ethylsuccinate.html","C43H75NO16","free base","N/A","CCOC(=O)CCC(=O)OC1C(CC(C)OC1OC2C(C)C(OC3CC(C)(OC)C(O)C(C)O3)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=O)C(C)CC2(C)O)N(C)C",2.591,12,2,14]
["S4061","Levobupivacaine HCl","e4","L3900-16","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Levobupivacaine HCl ((S)-(-)-Bupivacaine), the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.",324.89,"27262-48-2",{"v":64,"d":"64.00"},196.99,{"v":64,"d":"64.00"},196.99,"http://selleckchem.com/products/lvobupivacaine-hcl.html","C18H28N2O.HCl","Hydrochloride","(S)-(-)-Bupivacaine HCl","Cl.CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",4.692,1,1,5]
["S4064","Escitalopram Oxalate","f4","L3900-16","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.",414.43,"219861-08-2",{"v":83,"d":"83.00"},200.28,{"v":25,"d":"25.00"},60.32,"http://selleckchem.com/products/escitalopram-oxalate.html","C20H21FN2O.C2H2O4","Oxalate","N/A","CN(C)CCCC1(OCC2=CC(=CC=C12)C#N)C3=CC=C(F)C=C3.OC(=O)C(O)=O",0.257,3,0,6]
["S4065","Guanabenz Acetate","g4","L3900-16","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Guanabenz Acetate (WY-8678) is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.",291.13,"23256-50-0",{"v":58,"d":"58.00"},199.22,"<1","N/A","http://selleckchem.com/products/guanabenz-wy-8678-acetate.html","C8H8Cl2N4.C2H4O2","Acetate","WY-8678 Acetate","CC(O)=O.NC(=N)N/N=C/C1=C(Cl)C=CC=C1Cl",1.987,2,2,3]
["S4068","Tinidazole","h4","L3900-16","in 10mM DMSO","Parasite","Microbiology","Tinidazole (CP12574) is an anti-parasitic drug.",247.27,"19387-91-8",{"v":49,"d":"49.00"},198.16,"<1","N/A","http://selleckchem.com/products/tinidazole.html","C8H13N3O4S","free base","CP12574","CC[S](=O)(=O)CC[N]1C(=NC=C1[N+]([O-])=O)C",0.149,3,0,5]
["S4071","Griseofulvin","a5","L3900-16","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Griseofulvin, a production from some strains of the mold Penicillium griseofulvumam, is able to inhibit cell mitosis by interfering with microtubule function.",352.77,"126-07-8",{"v":50,"d":"50.00"},141.74,"<1","N/A","http://selleckchem.com/products/griseofulvin.html","C17H17ClO6","free base","N/A","COC1=CC(=C2C(=O)C3(OC2=C1Cl)C(C)CC(=O)C=C3OC)OC",2.495,6,0,3]
["S4076","Propranolol HCl","b5","L3900-16","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.",{"v":295.8,"d":"295.80"},"318-98-9",{"v":59,"d":"59.00"},199.46,{"v":6,"d":"6.00"},20.28,"http://selleckchem.com/products/propranolol-hcl.html","C16H21NO2.HCl","Hydrochloride","AY-64043, ICI-45520, NCS-91523","Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12",2.922,1,2,6]
["S4077","Mequinol","c5","L3900-16","in 10mM DMSO","Others","Others","Mequinol (4-Methoxyphenol) is a depigmentation agent.",124.14,"150-76-5",{"v":25,"d":"25.00"},201.39,{"v":25,"d":"25.00"},201.39,"http://selleckchem.com/products/mequinol.html","C7H8O2","free base","N/A","COC1=CC=C(O)C=C1",1.571,1,1,1]
["S4078","Mefenamic Acid","d5","L3900-16","in 10mM DMSO","COX","Neuronal Signaling","Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.",241.29,"61-68-7",{"v":48,"d":"48.00"},198.93,"<1","N/A","http://selleckchem.com/products/mefenamic-acid.html","C15H15NO2","free base","CI 473, CN-35355","CC1=C(C)C(=CC=C1)NC2=CC=CC=C2C(O)=O",3.982,1,1,3]
["S4079","Ticagrelor","e5","L3900-16","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Ticagrelor (AZD 6140, AR-C 126532XX) is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM.",522.57,"274693-27-5",{"v":100,"d":"100.00"},191.36,"<1","N/A","http://selleckchem.com/products/ticagrelor.html","C23H28F2N6O4S","free base","AZD 6140, AR-C 126532XX","CCCSC1=NC2=C(N=N[N]2C3CC(OCCO)C(O)C3O)C(=N1)NC4CC4C5=CC(=C(F)C=C5)F",2.843,5,4,10]
["S4080","Triamterene","f5","L3900-16","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.",253.26,"396-01-0",{"v":20,"d":"20.00"},78.97,"<1","N/A","http://selleckchem.com/products/triamterene.html","C12H11N7","free base","SKF8542","NC1=NC2=C(N=C(C3=CC=CC=C3)C(=N2)N)C(=N1)N",1.017,4,3,1]
["S4081","Sulfacetamide Sodium","g5","L3900-16","in 10mM DMSO","Anti-infection,Autophagy","Immunology & Inflammation","Sulfacetamide Sodium is an anti-biotic.",236.22,"127-56-0",{"v":19,"d":"19.00"},80.43,{"v":51,"d":"51.00"},{"v":215.9,"d":"215.90"},"http://selleckchem.com/products/sulfacetamide-sodium.html","C8H10N2O3S.Na","Sodium Salt","N/A","[Na+].CC(=O)[N-][S](=O)(=O)C1=CC=C(N)C=C1",-0.118,3,1,2]
["S4082","Spiramycin","h5","L3900-16","in 10mM DMSO","Antibiotics","Microbiology","Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).",843.05,"8025-81-8",{"v":100,"d":"100.00"},118.62,"<1","N/A","http://selleckchem.com/products/spiramycin.html","C43H74N2O14","free base","Formacidine","COC1C(O)CC(=O)OC(C)C/C=C/C=C/C(OC2CCC(C(C)O2)N(C)C)C(C)CC(CC=O)C1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C",2.049,10,3,11]
["S4084","Lomerizine 2HCl","a6","L3900-16","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.",541.46,"101477-54-7",{"v":100,"d":"100.00"},184.69,"<1","N/A","http://selleckchem.com/products/lomerizine-hcl.html","C27H30F2N2O3.2HCl","Dihydrochloride","KB-2796","Cl.Cl.COC1=C(OC)C(=C(CN2CCN(CC2)C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C=C1)OC",6.182,3,0,8]
["S4085","Levobetaxolol HCl","b6","L3900-16","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Levobetaxolol (AL 1577A,(S)-Betaxolol hydrochloride) exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively.",343.89,"116209-55-3",{"v":69,"d":"69.00"},200.65,{"v":69,"d":"69.00"},200.65,"http://selleckchem.com/products/levobetaxolol-hcl.html","C18H29NO3.HCl","Hydrochloride","AL 1577A,(S)-Betaxolol hydrochloride","Cl.CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1",2.959,2,2,11]
["S4086","Loxapine Succinate","c6","L3900-16","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Loxapine Succinate(NSC 759578) is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.",{"v":445.9,"d":"445.90"},"27833-64-3",{"v":89,"d":"89.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/loxapine-succinate.html","C18H18ClN3O.C4H6O4","Succinate","NSC 759578","CN1CCN(CC1)C2=NC3=C(OC4=C2C=C(Cl)C=C4)C=CC=C3.OC(=O)CCC(O)=O",0.039,4,0,4]
["S4089","Halobetasol Propionate","d6","L3900-16","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Halobetasol Propionate (BMY-30056, CGP-14458,Ulobetasol propionate) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.",484.96,"66852-54-8",{"v":97,"d":"97.00"},200.02,"<1","N/A","http://selleckchem.com/products/halobetasol-propionate.html","C25H31ClF2O5","free base","BMY-30056, CGP-14458,Ulobetasol propionate","CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.797,4,1,5]
["S4091","Ifenprodil Tartrate","e6","L3900-16","in 10mM DMSO","NMDAR","Neuronal Signaling","Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.",800.98,"23210-58-4",{"v":95,"d":"95.00"},{"v":118.6,"d":"118.60"},{"v":9,"d":"9.00"},11.24,"http://selleckchem.com/products/ifenprodil-tartrate.html","2(C21H27NO2).C4H6O6","Tartrate","N/A","CC(C(O)C1=CC=C(O)C=C1)N2CCC(CC2)CC3=CC=CC=C3.CC(C(O)C4=CC=C(O)C=C4)N5CCC(CC5)CC6=CC=CC=C6.OC(C(O)C(O)=O)C(O)=O",0.638,2,6,13]
["S4092","Pramoxine HCl","f6","L3900-16","in 10mM DMSO","Others","Others","Pramoxine(Pramocaine hydrochloride) is a topical local anesthetic that has been shown to have antipruritic properties.",329.86,"637-58-1",{"v":66,"d":"66.00"},200.08,{"v":66,"d":"66.00"},200.08,"http://selleckchem.com/products/pramoxine-hcl.html","C17H27NO3.HCl","Hydrochloride","Pramocaine hydrochloride","Cl.CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1",3.396,3,0,9]
["S4095","Difluprednate","g6","L3900-16","in 10mM DMSO","Others","Others","Difluprednate (difluoroprednisolone butyrate acetate, DFBA, CM 9155) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications.",508.55,"23674-86-4",{"v":100,"d":"100.00"},196.64,"<1","N/A","http://selleckchem.com/products/difluprednate.html","C27H34F2O7","free base","CM 9155","CCCC(=O)OC1(CCC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)COC(C)=O",3.108,6,1,8]
["S4096","Droperidol","h6","L3900-16","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system.",379.43,"548-73-2",{"v":76,"d":"76.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/droperidol.html","C22H22FN3O2","free base","NSC 169874,Dehydrobenzperidol","FC1=CC=C(C=C1)C(=O)CCCN2CCC(=CC2)N3C(=O)NC4=C3C=CC=C4",3.049,2,1,6]
["S4099","Dexlansoprazole","a7","L3900-16","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell.",369.36,"138530-94-6",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/dexlansoprazole.html","C16H14F3N3O2S","free base","T 168390, TAK 390,(R)-Lansoprazole","CC1=C(C[S](=O)C2=NC3=C([NH]2)C=CC=C3)N=CC=C1OCC(F)(F)F",3.442,4,1,6]
["S4100","Esmolol HCl","b7","L3900-16","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.",331.83,"81161-17-3",{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},"http://selleckchem.com/products/esmolol-hcl.html","C16H25NO4.HCl","Hydrochloride","ASL8052","Cl.COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1",{"v":2.36,"d":"2.360"},3,2,10]
["S4101","Voglibose","c7","L3900-16","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.",267.28,"83480-29-9",{"v":74,"d":"74.00"},276.86,{"v":74,"d":"74.00"},276.86,"http://selleckchem.com/products/voglibose.html","C10H21NO7","free base","AO 128","OCC(CO)NC1CC(O)(CO)C(O)C(O)C1O",-4.083,0,7,5]
["S4102","Eprosartan Mesylate","d7","L3900-16","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Eprosartan(SKF-108566J) is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells.",520.62,"144143-96-4",{"v":104,"d":"104.00"},199.76,"<1","N/A","http://selleckchem.com/products/eprosartan-mesylate.html","C23H24N2O4S.CH4O3S","Mesylate","SKF-108566J","CCCCC1=NC=C(\\C=C(CC2=CC=CS2)\\C(O)=O)[N]1CC3=CC=C(C=C3)C(O)=O.C[S](O)(=O)=O",4.418,3,0,10]
["S4107","Clofazimine","e7","L3900-16","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Dyes,Phospholipase (e.g. PLA)","Metabolism","Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.",{"v":473.4,"d":"473.40"},"2030-63-9",{"v":5,"d":"5.00"},10.56,"<1","N/A","http://selleckchem.com/products/clofazimine.html","C27H22Cl2N4","free base","NSC-141046","CC(C)N=C1C=C2N(C3=CC=C(Cl)C=C3)C4=C(C=CC=C4)N=C2C=C1NC5=CC=C(Cl)C=C5",7.137,2,1,4]
["S4110","Estradiol Benzoate","f7","L3900-16","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Estradiol benzoate(β-Estradiol 3-benzoate) is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.",376.49,"50-50-0",{"v":75,"d":"75.00"},199.21,"<1","N/A","http://selleckchem.com/products/estradiol-benzoate.html","C25H28O3","free base","β-Estradiol 3-benzoate","CC12CCC3C(CCC4=CC(=CC=C34)OC(=O)C5=CC=CC=C5)C1CCC2O",5.512,2,1,3]
["S4111","Dicloxacillin Sodium","g7","L3900-16","in 10mM DMSO","β-lactamase","Microbiology","Dicloxacillin Sodium (Veracillin, BRL1702) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.",510.32,"343-55-5",{"v":100,"d":"100.00"},195.96,{"v":100,"d":"100.00"},195.96,"http://selleckchem.com/products/dicloxacillin-sodium.html","C19H17Cl2N3O5S.H2O.Na","Sodium Salt","Veracillin, BRL1702","O.CC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C(=O)O[Na])C(=NO1)C4=C(Cl)C=CC=C4Cl",2.848,6,1,5]
["S4112","Desvenlafaxine Succinate hydrate","h7","L3900-16","in 10mM DMSO","Adrenergic Receptor,Serotonin Transporter","Neuronal Signaling","Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.",399.48,"386750-22-7",{"v":80,"d":"80.00"},191.22,"<1","N/A","http://selleckchem.com/products/desvenlafaxine-succinate.html","C16H25NO2.C4H6O4.H2O","Succinate hydrate","WY 45233  Succinate","O.CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2.OC(=O)CCC(O)=O",-0.598,2,1,7]
["S4113","Desvenlafaxine","a8","L3900-16","in 10mM DMSO","Adrenergic Receptor,Serotonin Transporter","Neuronal Signaling","Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.",263.38,"93413-62-8",{"v":37,"d":"37.00"},140.48,"<1","N/A","http://selleckchem.com/products/desvenlafaxine.html","C16H25NO2","Free Base","WY 45233  Succinate","CN(C)CC(C1=CC=C(O)C=C1)C2(O)CCCCC2",2.796,0,1,4]
["S4116","Isovaleramide","b8","L3900-16","in 10mM DMSO","Dehydrogenase","Metabolism","Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.",101.15,"541-46-8",{"v":20,"d":"20.00"},197.73,"<1","N/A","http://selleckchem.com/products/isovaleramide.html","C5H11NO","free base","3-Methylbutanamide","CC(C)CC(N)=O",0.542,1,1,2]
["S4118","Histamine 2HCl","c8","L3900-16","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Histamine(Ceplene) is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.",184.07,"56-92-8",{"v":3,"d":"3.00"},{"v":16.3,"d":"16.30"},{"v":37,"d":"37.00"},201.01,"http://selleckchem.com/products/histamine-2hcl.html","C5H9N3.2HCl","Dihydrochloride","Ceplene","Cl.Cl.NCCC1=C[NH]C=N1",{"v":0.05,"d":"0.050"},1,2,2]
["S4123","Timolol Maleate","d8","L3900-16","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Timolol Maleate (MK-950,(S)-Timolol Maleate) is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.",432.49,"26921-17-5",{"v":86,"d":"86.00"},198.85,"<1","N/A","http://selleckchem.com/products/timolol-maleate.html","C13H24N4O3S.C4H4O4","Maleate","MK-950,(S)-Timolol Maleate","CC(C)(C)NCC(O)COC1=NSN=C1N2CCOCC2.OC(=O)\\C=C/C(O)=O",-1.539,6,2,9]
["S4125","Sodium Phenylbutyrate","e8","L3900-16","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.",187.19,"1716-12-7",{"v":8,"d":"8.00"},42.97,{"v":30,"d":"30.00"},161.13,"http://selleckchem.com/products/sodium-phenylbutyrate.html","C10H11O2.Na","Sodium Salt","4-PBA, 4-Phenylbutyric acid, NaPB","[Na]OC(=O)CCCC1=CC=CC=C1",2.497,2,0,5]
["S4131","Levodropropizine","f8","L3900-16","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levodropropizine((S)-(-)-Dropropizine,DF-526) possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.",236.31,"99291-25-5",{"v":47,"d":"47.00"},198.89,{"v":15,"d":"15.00"},63.48,"http://selleckchem.com/products/levodropropizine.html","C13H20N2O2","free base","(S)-(-)-Dropropizine,DF-526","OCC(O)CN1CCN(CC1)C2=CC=CC=C2",0.899,0,2,4]
["S4143","Pentoxyverine Citrate","g8","L3900-16","in 10mM DMSO","AChR","Neuronal Signaling","Pentoxyverine Citrate (Carbetapentane) is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.",525.59,"23142-01-0",{"v":100,"d":"100.00"},190.26,{"v":100,"d":"100.00"},190.26,"http://selleckchem.com/products/pentoxyverine-carbetapentane-citrate.html","C20H31NO3.C6H8O7","Citrate","Carbetapentane Citrate","CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=N2)C(C)C.O[P](O)(O)=O",2.949,2,1,8]
["S4147","Azithromycin Dihydrate","h8","L3900-16","in 10mM DMSO","Anti-infection","Microbiology","Azithromycin Dihydrate(CP-62993 dihydrate) is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.",785.02,"117772-70-0",{"v":100,"d":"100.00"},127.39,{"v":10,"d":"10.00"},12.74,"http://selleckchem.com/products/azithromycin-dihydrate.html","C38H72N2O12.2H2O","free base","CP-62993 dihydrate","O.O.CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",1.663,7,3,7]
["S4148","Ampicillin Trihydrate","a9","L3900-16","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Bacterial","Microbiology","Ampicillin Trihydrate (NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.",403.45,"7177-48-2",{"v":81,"d":"81.00"},200.77,{"v":2,"d":"2.00"},4.96,"http://selleckchem.com/products/ampicillin-trihydrate.html","C16H19N3O4S.3H2O","free base","NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate","O.O.O.CC1(C)SC2C(NC(=O)C(N)C3=CC=CC=C3)C(=O)N2C1C(O)=O",-2.919,3,2,4]
["S4152","Ethamsylate","b9","L3900-16","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Ethamsylate (Etamsylate) is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.",263.31,"2624-44-4",{"v":53,"d":"53.00"},201.28,{"v":53,"d":"53.00"},201.28,"http://selleckchem.com/products/ethamsylate.html","C6H6O5S.C4H11N","Diethylamine","Etamsylate","CCNCC.OC1=CC=C(O)C(=C1)[S](O)(=O)=O",{"v":1.16,"d":"1.160"},0,3,3]
["S4155","Chlorzoxazone","c9","L3900-16","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.",169.57,"95-25-0",{"v":34,"d":"34.00"},200.51,"<1","N/A","http://selleckchem.com/products/chlorzoxazone.html","C7H4ClNO2","free base","Chlorzoxazon,Paraflex","ClC1=CC2=C(OC(=O)N2)C=C1",2.004,2,1,0]
["S4159","Bezafibrate","d9","L3900-16","in 10mM DMSO","PPAR","Metabolism","Bezafibrate (BM 15075) is the first clinically tested dual and pan-PPAR co-agonism.",361.82,"41859-67-0",{"v":72,"d":"72.00"},198.99,"<1","N/A","http://selleckchem.com/products/bezafibrate.html","C19H20ClNO4","free base","BM 15075","CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O",3.868,3,1,7]
["S4160","Penicillin G Sodium","e9","L3900-16","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture","Microbiology","Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp.",356.37,"69-57-8",{"v":71,"d":"71.00"},199.23,{"v":71,"d":"71.00"},199.23,"http://selleckchem.com/products/benzylpenicillin-sodium.html","C16H18N2O4S.Na","Sodium Salt","Benzylpenicillin Sodium","[Na+].CC1(C)SC2C(NC(=O)CC3=CC=CC=C3)C(=O)N2C1C([O-])=O",{"v":-0.35,"d":"-0.350"},2,1,4]
["S4162","Benzethonium Chloride","f9","L3900-16","in 10mM DMSO","AChR","Neuronal Signaling","Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.",448.08,"121-54-0",{"v":90,"d":"90.00"},200.86,{"v":90,"d":"90.00"},200.86,"http://selleckchem.com/products/benzethonium-chloride.html","C27H42NO2.Cl","Chloride","N/A","[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1",2.147,2,0,12]
["S4163","Doxycycline Hyclate (WC2031)","g9","L3900-16","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,MMP","Proteases","Doxycycline Hyclate (WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate) is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).",512.94,"24390-14-5",{"v":100,"d":"100.00"},194.95,{"v":100,"d":"100.00"},194.95,"http://selleckchem.com/products/doxycycline-hyclate.html","C22H24N2O8.1/2C2H6O.HCl.1/2H2O","hyclate","Doxycycline hydrochloride hemiethanolate hemihydrate","O.Cl.Cl.CCO.CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C(O)C=CC=C14)O)O.CC5C6C(O)C7C(N(C)C)C(=C(C(N)=O)C(=O)C7(O)C(=C6C(=O)C8=C(O)C=CC=C58)O)O",-0.955,6,11,4]
["S4164","Doxofylline","h9","L3900-16","in 10mM DMSO","PDE","Metabolism","Doxofylline (Doxophylline) is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.",266.25,"69975-86-6",{"v":53,"d":"53.00"},199.06,{"v":24,"d":"24.00"},90.14,"http://selleckchem.com/products/doxofylline.html","C11H14N4O4","free base","Doxophylline","CN1C(=O)N(C)C2=C([N](CC3OCCO3)C=N2)C1=O",-0.344,5,0,2]
["S4165","Benzydamine HCl","a10","L3900-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.",345.87,"132-69-4",{"v":69,"d":"69.00"},{"v":199.5,"d":"199.50"},{"v":69,"d":"69.00"},{"v":199.5,"d":"199.50"},"http://selleckchem.com/products/benzydamine-hcl.html","C19H23N3O.HCl","Hydrochloride","AF864","Cl.CN(C)CCCOC1=N[N](CC2=CC=CC=C2)C3=CC=CC=C13",4.368,2,0,7]
["S4166","Chlorpropamide","b10","L3900-16","in 10mM DMSO","ATPase","Transmembrane Transporters","Chlorpropamide inhibits Na(+),K(+)-ATPase and stimulates a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane. Chlorpropamide is a sulfonylurea class drug for type 2 diabetes mellitus.",276.74,"94-20-2",{"v":55,"d":"55.00"},198.74,"<1","N/A","http://selleckchem.com/products/chlorpropamide.html","C10H13ClN2O3S","free base","N/A","CCCNC(=O)N[S](=O)(=O)C1=CC=C(Cl)C=C1",2.058,3,2,4]
["S4169","Teriflunomide","c10","L3900-16","in 10mM DMSO","Dehydrogenase,Immunology & Inflammation related","Metabolism","Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.",270.21,"163451-81-8",{"v":32,"d":"32.00"},118.43,"<1","N/A","http://selleckchem.com/products/teriflunomide.html","C12H9F3N2O2","free base","A77 1726, HMR-1726","C/C(O)=C(C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F",2.091,1,2,3]
["S4170","Coumarin","d10","L3900-16","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.",146.14,"91-64-5",{"v":29,"d":"29.00"},198.44,"<1","N/A","http://selleckchem.com/products/coumarin.html","C9H6O2","free base","N/A","O=C1OC2=C(C=CC=C2)C=C1",1.899,2,0,0]
["S4172","Cetylpyridinium Chloride","e10","L3900-16","in 10mM DMSO","Anti-infection","Microbiology","Cetylpyridinium chloride(CPC) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.",339.99,"123-03-5",{"v":68,"d":"68.00"},200.01,{"v":68,"d":"68.00"},200.01,"http://selleckchem.com/products/cetylpyridinium-chloride.html","C21H38N.Cl","Chloride","CPC","[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1",5.563,0,0,15]
["S4176","Trometamol","f10","L3900-16","in 10mM DMSO","COX","Neuronal Signaling","Trometamol(Tromethamine) is a proton acceptor used to treat acidemia.",121.14,"77-86-1",{"v":2,"d":"2.00"},16.51,{"v":24,"d":"24.00"},198.12,"http://selleckchem.com/products/trometamol.html","C4H11NO3","free base","Tromethamine","NC(CO)(CO)CO",-2.381,0,4,3]
["S4177","Uracil","g10","L3900-16","in 10mM DMSO","Others","Others","Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical.",112.09,"66-22-8",{"v":22,"d":"22.00"},196.27,"<1","N/A","http://selleckchem.com/products/uracil.html","C4H4N2O2","free base","N/A","O=C1NC=CC(=O)N1",-1.012,2,2,0]
["S4181","Nicardipine HCl","h10","L3900-16","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.",515.99,"54527-84-3",{"v":100,"d":"100.00"},{"v":193.8,"d":"193.80"},"<1","N/A","http://selleckchem.com/products/nicardipine-hcl.html","C26H29N3O6.HCl","Hydrochloride","RS-69216,YC-93","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",{"v":3.87,"d":"3.870"},4,1,11]
["S4184","Penciclovir","a11","L3900-16","in 10mM DMSO","Antiviral","Microbiology","Penciclovir (BRL-39123, VSA 671,NSC-759624) is a purine acyclic nucleoside analogue with potent antiviral activity.",253.26,"39809-25-1",{"v":34,"d":"34.00"},134.25,{"v":1,"d":"1.00"},3.95,"http://selleckchem.com/products/penciclovir.html","C10H15N5O3","free base","BRL-39123, VSA 671,NSC-759624","NC1=NC(=O)C2=C(N1)[N](CCC(CO)CO)C=N2",-1.533,3,4,5]
["S4185","Tiratricol","b11","L3900-16","in 10mM DMSO","THR","Metabolism","Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.",621.93,"51-24-1",{"v":100,"d":"100.00"},160.79,"<1","N/A","http://selleckchem.com/products/tiratricol.html","C14H9I3O4","free base","triiodothyroacetic acid","OC(=O)CC1=CC(=C(OC2=CC=C(O)C(=C2)I)C(=C1)I)I",4.547,2,1,4]
["S4191","Betamipron","c11","L3900-16","in 10mM DMSO","Anti-infection","Microbiology","Betamipron (CS-443,N-Benzoyl-β-alanine) is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and prevent nephrotoxicity.",{"v":193.2,"d":"193.20"},"3440-28-6",{"v":39,"d":"39.00"},201.86,"<1","N/A","http://selleckchem.com/products/betamipron.html","C10H11NO3","free base","CS-443,N-Benzoyl-β-alanine","OC(=O)CCNC(=O)C1=CC=CC=C1",0.767,2,1,4]
["S4200","Tolperisone HCl","d11","L3900-16","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.",281.82,"3644-61-9",{"v":56,"d":"56.00"},198.71,{"v":56,"d":"56.00"},198.71,"http://selleckchem.com/products/tolperisone-hcl.html","C16H23NO.HCl","Hydrochloride","N/A","Cl.CC(CN1CCCCC1)C(=O)C2=CC=C(C)C=C2",4.072,1,0,4]
["S4202","Verapamil (CP-16533-1) HCl","e11","L3900-16","in 10mM DMSO","Calcium Channel,P450 (e.g. CYP17),P-gp","Transmembrane Transporters","Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.",491.06,"152-11-4",{"v":98,"d":"98.00"},199.57,{"v":50,"d":"50.00"},101.82,"http://selleckchem.com/products/verapami-hcl.html","C27H38N2O4.HCl","Hydrochloride","(±)-Verapamil hydrochloride","Cl.COC1=CC=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC=C(OC)C(=C2)OC)C=C1OC",5.916,4,0,13]
["S4204","Isosorbide","f11","L3900-16","in 10mM DMSO","Others","Others","Isosorbide(D-Isosorbide,Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose, used as a diuretic.",146.14,"652-67-5",{"v":29,"d":"29.00"},198.44,{"v":29,"d":"29.00"},198.44,"http://selleckchem.com/products/isosorbide.html","C6H10O4","free base","D-Isosorbide,Dianhydro-D-glucitol","OC1COC2C(O)COC12",-1.408,2,2,0]
["S4206","Cysteamine HCl","g11","L3900-16","in 10mM DMSO","Antioxidant","Metabolism","Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.",113.61,"156-57-0",{"v":23,"d":"23.00"},202.45,{"v":23,"d":"23.00"},202.45,"http://selleckchem.com/products/cysteamine-hcl.html","C2H7NS.HCl","Hydrochloride","Mercaptamine","Cl.NCCS",0.166,0,1,1]
["S4210","Benzocaine","h11","L3900-16","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Benzocaine(ethyl 4-aminobenzoate) is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.",165.19,"94-09-7",{"v":33,"d":"33.00"},199.77,"<1","N/A","http://selleckchem.com/products/benzocaine.html","C9H11NO2","Free Base","ethyl 4-aminobenzoate","CCOC(=O)C1=CC=C(N)C=C1",1.287,2,1,3]
["S4212","Tenatoprazole","a2","L3900-17","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Tenatoprazole (TU-199,STU-Na) is a prodrug of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. Tenatoprazole labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of tenatoprazole is bound to the H(+),K(+)-ATPase.",{"v":346.4,"d":"346.40"},"113712-98-4",{"v":46,"d":"46.00"},132.79,"<1","N/A","http://selleckchem.com/products/tenatoprazole.html","C16H18N4O3S","free base","TU-199,STU-Na","COC1=CC=C2[NH]C(=NC2=N1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.488,6,1,5]
["S4213","Dirithromycin","b2","L3900-17","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Dirithromycin (LY-237216, ASE 136,Dynabac) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.",835.07,"62013-04-1",{"v":11,"d":"11.00"},13.17,"<1","N/A","http://selleckchem.com/products/dirithromycin.html","C42H78N2O14","free base","LY-237216, ASE 136,Dynabac","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C4NC(COCCOC)OC(C4C)C1(C)O",1.869,10,3,12]
["S4214","Sucralose","c2","L3900-17","in 10mM DMSO","Others","Others","Sucralose (E955,Trichloro Sucrose) is an artificial and noncaloric sweetener, not broken down by the body.",397.63,"56038-13-2",{"v":80,"d":"80.00"},201.19,{"v":80,"d":"80.00"},201.19,"http://selleckchem.com/products/sucralose.html","C12H19Cl3O8","free base","E955,Trichloro Sucrose","OCC1OC(OC2(CCl)OC(CCl)C(O)C2O)C(O)C(O)C1Cl",-0.697,3,5,5]
["S4217","Liothyronine Sodium","d2","L3900-17","in 10mM DMSO","THR","Metabolism","Liothyronine Sodium(Cytomel) is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.",672.96,"55-06-1",{"v":100,"d":"100.00"},{"v":148.6,"d":"148.60"},"<1","N/A","http://selleckchem.com/products/liothyronine-sodium.html","C15H12I3NO4.Na","sodium","Cytomel","[Na+].NC(CC1=CC(=C(OC2=CC=C(O)C(=C2)I)C(=C1)I)I)C([O-])=O",2.452,1,2,5]
["S4221","Benzbromarone","e2","L3900-17","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Benzbromarone(Desuric) is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.",424.08,"3562-84-3",{"v":85,"d":"85.00"},200.43,"<1","N/A","http://selleckchem.com/products/benzbromarone.html","C17H12Br2O3","free base","Desuric","CCC1=C(C(=O)C2=CC(=C(O)C(=C2)Br)Br)C3=C(O1)C=CC=C3",5.604,2,1,3]
["S4222","Piperacillin Sodium","f2","L3900-17","in 10mM DMSO","Antibiotics","Microbiology","Piperacillin (CL227193,Pipracil) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.",539.54,"59703-84-3",{"v":100,"d":"100.00"},185.34,{"v":100,"d":"100.00"},185.34,"http://selleckchem.com/products/piperacillin-sodium.html","C23H27N5O7S.Na","Sodium Salt","CL227193,Pipracil","[Na+].CCN1CCN(C(=O)NC(C(=O)NC2C3SC(C)(C)C(N3C2=O)C([O-])=O)C4=CC=CC=C4)C(=O)C1=O",-1.558,5,2,6]
["S4223","Mevastatin","g2","L3900-17","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.",390.51,"73573-88-3",{"v":78,"d":"78.00"},199.74,"<1","N/A","http://selleckchem.com/products/mevastatin.html","C23H34O5","free base","ML-236B,Compactin","CCC(C)C(=O)OC1CCC=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",3.966,4,1,7]
["S4224","Erythritol","h2","L3900-17","in 10mM DMSO","Others","Others","Erythritol(meso-Erythritol) is a sugar alcohol used as low-calorie sweetener.",122.12,"149-32-6",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/erythritol.html","C4H10O4","free base","meso-Erythritol","OCC(O)C(O)CO",-1.919,0,4,3]
["S4225","Mexiletine HCl","a3","L3900-17","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Mexiletine HCl (KO1173,Mexitil) belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.",215.72,"5370-01-4",{"v":43,"d":"43.00"},199.33,{"v":43,"d":"43.00"},199.33,"http://selleckchem.com/products/mexiletine-hcl.html","C11H17NO.HCl","Hydrochloride","KO1173,Mexitil","Cl.CC(N)COC1=C(C)C=CC=C1C",2.716,1,1,3]
["S4227","Fidaxomicin","b3","L3900-17","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fidaxomicin (OPT-80, PAR-101,Dificid) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.",1058.04,"873857-62-6",{"v":100,"d":"100.00"},94.51,"<1","N/A","http://selleckchem.com/products/fidaxomicin.html","C52H74Cl2O18","free base","OPT-80, PAR-101,Dificid","CCC1\\C=C(C)/C(O)C\\C=C\\C=C(COC2OC(C)C(OC(=O)C3=C(CC)C(=C(O)C(=C3O)Cl)Cl)C(O)C2OC)\\C(=O)OC(C\\C=C(C)\\C=C(C)\\C1OC4OC(C)(C)C(OC(=O)C(C)C)C(O)C4O)C(C)O",7.774,11,7,15]
["S4228","Fluorometholone Acetate","c3","L3900-17","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluorometholone Acetate (NSC 47438,Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.",{"v":418.5,"d":"418.50"},"3801-06-7",{"v":83,"d":"83.00"},198.33,"<1","N/A","http://selleckchem.com/products/fluorometholone-acetate.html","C24H31FO5","free base","NSC 47438,Oxylone acetate","CC1CC2C3CCC(OC(C)=O)(C(C)=O)C3(C)CC(O)C2(F)C4(C)C=CC(=O)C=C14",2.691,4,1,3]
["S4229","Oxybuprocaine HCl","d3","L3900-17","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Oxybuprocaine HCl(oxybuprocaine hydrochloride) is a local anesthetic, which is used especially in ophthalmology and otolaryngology.  Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions",344.88,"5987-82-6",{"v":69,"d":"69.00"},200.07,{"v":69,"d":"69.00"},200.07,"http://selleckchem.com/products/oxybuprocaine-hcl.html","C17H28N2O3.HCl","Hydrochloride","oxybuprocaine hydrochloride","Cl.CCCCOC1=CC(=CC=C1N)C(=O)OCCN(CC)CC",3.469,3,1,11]
["S4230","Oxaprozin","e3","L3900-17","in 10mM DMSO","COX","Metabolism","Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.",293.32,"21256-18-8",{"v":59,"d":"59.00"},201.15,"<1","N/A","http://selleckchem.com/products/oxaprozin.html","C18H15NO3","free base","WY-21743,nsc 310839","OC(=O)CCC1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3",{"v":3.59,"d":"3.590"},3,0,5]
["S4231","Pilocarpine HCl","f3","L3900-17","in 10mM DMSO","AChR","Neuronal Signaling","Pilocarpine HCl (NSC 5746) is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.",244.72,"54-71-7",{"v":48,"d":"48.00"},196.14,{"v":48,"d":"48.00"},196.14,"http://selleckchem.com/products/pilocarpine-hcl.html","C11H16N2O2.HCl","Hydrochloride","NSC 5746 HCl","Cl.CCC1C(COC1=O)CC2=CN=C[N]2C",1.347,3,0,3]
["S4235","Phenazopyridine HCl","g3","L3900-17","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.",{"v":249.7,"d":"249.70"},"136-40-3",{"v":50,"d":"50.00"},200.24,"<1","N/A","http://selleckchem.com/products/phenazopyridine-hcl.html","C11H11N5.HCl","Hydrochloride","N/A","Cl.NC1=NC(=C(C=C1)N=NC2=CC=CC=C2)N",3.015,3,2,2]
["S4237","Primaquine Diphosphate","h3","L3900-17","in 10mM DMSO","Anti-infection","Microbiology","Primaquine Diphosphate is a transmission-blocking anti-malarial clinically available, displaying a marked activity against gametocytes of all species of human malaria.",455.34,"63-45-6",{"v":91,"d":"91.00"},199.85,{"v":91,"d":"91.00"},199.85,"http://selleckchem.com/products/primaquine-diphosphate.html","C15H21N3O.2H3O4P","Diphosphate","N/A","COC1=CC(=C2N=CC=CC2=C1)NC(C)CCCN.O[P](O)(O)=O.O[P](O)(O)=O",1.062,2,2,6]
["S4238","Cepharanthine","a4","L3900-17","in 10mM DMSO","TNF-alpha","Apoptosis","Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.",606.71,"481-49-2",{"v":100,"d":"100.00"},164.82,"<1","N/A","http://selleckchem.com/products/cepharanthine.html","C37H38N2O6","free base","NSC-623442","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C(=C6OCOC6=C5)OC7=C(OC)C=C8CCN(C)C(CC(=C2)C=C1)C8=C7)C=C3",7.019,6,0,2]
["S4239","Bergapten","b4","L3900-17","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.",216.19,"484-20-8",{"v":5,"d":"5.00"},23.13,"<1","N/A","http://selleckchem.com/products/bergapten.html","C12H8O4","free base","N/A","COC1=C2C=COC2=CC3=C1C=CC(=O)O3",2.187,4,0,1]
["S4240","Doxylamine Succinate","c4","L3900-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.",388.46,"562-10-7",{"v":78,"d":"78.00"},200.79,{"v":78,"d":"78.00"},200.79,"http://selleckchem.com/products/doxylamine-succinate.html","C17H22N2O.C4H6O4","Succinate","N/A","CN(C)CCOC(C)(C1=CC=CC=C1)C2=CC=CC=N2.OC(=O)CCC(O)=O",-0.527,4,0,9]
["S4246","Tranylcypromine (2-PCPA) HCl","d4","L3900-17","in 10mM DMSO","MAO","Metabolism","Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.",169.65,"1986-47-6",{"v":33,"d":"33.00"},194.52,{"v":33,"d":"33.00"},194.52,"http://selleckchem.com/products/tranylcypromine-2-pcpa-hcl.html","C9H12ClN","Hydrochloride","SKF-385 HCl, Parnate,2-PCPA","Cl.NC1CC1C2=CC=CC=C2",2.309,0,1,1]
["S4247","Prucalopride Succinate","e4","L3900-17","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Prucalopride(R-108512) is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively.",485.96,"179474-85-2",{"v":97,"d":"97.00"},{"v":199.6,"d":"199.60"},{"v":97,"d":"97.00"},{"v":199.6,"d":"199.60"},"http://selleckchem.com/products/prucalopride-succinat.html","C18H26ClN3O3.C4H6O4","Succinat","R-108512","COCCCN1CCC(CC1)NC(=O)C2=C3OCCC3=C(N)C(=C2)Cl.OC(=O)CCC(O)=O",-2.338,5,2,9]
["S4248","Bromfenac Sodium","f4","L3900-17","in 10mM DMSO","COX","Neuronal Signaling","Bromfenac Sodium (AHR 10282R,Bromsite,Bromday,Prolensa,Xibrom) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.",356.15,"91714-93-1",{"v":71,"d":"71.00"},199.35,{"v":71,"d":"71.00"},199.35,"http://selleckchem.com/products/bromfenac-sodium.html","C15H11BrNO3.Na","Sodium Salt","AHR 10282R,Bromsite,Bromday,Prolensa,Xibrom","[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=C(Br)C=C2",1.426,1,1,4]
["S4253","Epinastine HCl","g4","L3900-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Epinastine (WAL-801CL) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.",285.77,"108929-04-0",{"v":57,"d":"57.00"},199.46,{"v":57,"d":"57.00"},199.46,"http://selleckchem.com/products/epinastine-hcl.html","C16H15N3.HCl","Hydrochloride","WAL-801CL HCl","Cl.NC1=NCC2N1C3=CC=CC=C3CC4=CC=CC=C24",3.164,1,1,0]
["S4255","Quinacrine 2HCl","h4","L3900-17","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective  phospholipase A2 inhibitor.",472.88,"69-05-6",{"v":14,"d":"14.00"},29.61,{"v":53,"d":"53.00"},112.08,"http://selleckchem.com/products/quinacrine-2hcl.html","C23H30ClN3O.2HCl","Dihydrochloride","Quinacrine dihydrochloride","Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",{"v":6.43,"d":"6.430"},2,1,9]
["S4256","Buspirone HCl","a5","L3900-17","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.",421.96,"33386-08-2",{"v":84,"d":"84.00"},199.07,{"v":84,"d":"84.00"},199.07,"http://selleckchem.com/products/buspirone-hcl.html","C21H31N5O2.HCl","Hydrochloride","Buspirone hydrochloride","Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)C4=NC=CC=N4",2.403,4,0,6]
["S4258","Luliconazole","b5","L3900-17","in 10mM DMSO","Fungal","Microbiology","Luliconazole(NND 502) is a broad-spectrum antifungal drug.",354.28,"187164-19-8",{"v":71,"d":"71.00"},200.41,"<1","N/A","http://selleckchem.com/products/luliconazole.html","C14H9Cl2N3S2","free base","NND 502","ClC1=CC=C(C2CSC(/S2)=C(C#N)\\[N]3C=CN=C3)C(=C1)Cl",4.031,1,0,2]
["S4259","Vilazodone HCl","c5","L3900-17","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and  a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.",477.99,"163521-08-2",{"v":96,"d":"96.00"},200.84,"<1","N/A","http://selleckchem.com/products/vilazodone-hcl.html","C26H27N5O2.HCl","Hydrochloride","EMD68843,SB659746A","Cl.NC(=O)C1=CC2=C(O1)C=CC(=C2)N3CCN(CCCCC4=C[NH]C5=C4C=C(C=C5)C#N)CC3",4.918,2,2,7]
["S4260","Tamibarotene","d5","L3900-17","in 10mM DMSO","Retinoid Receptor","Metabolism","Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.",351.44,"94497-51-5",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://selleckchem.com/products/tamibarotene.html","C22H25NO3","free base","Am 80","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S4261","EUK 134","e5","L3900-17","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.",416.74,"81065-76-1",{"v":83,"d":"83.00"},199.16,{"v":13,"d":"13.00"},31.19,"http://selleckchem.com/products/euk-134.html","C18H18ClMnN2O4","Complex","N/A","COC1=C2O[Mn]|3|4(Cl)OC5=C(OC)C=CC=C5C=N|3CCN|4=CC2=CC=C1",3.526,4,0,2]
["S4263","Efaproxiral Sodium","f5","L3900-17","in 10mM DMSO","ROS","Immunology & Inflammation","Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. Efaproxiral Sodium is used for brain metastases originating from breast cancer.",363.38,"170787-99-2",{"v":73,"d":"73.00"},200.89,{"v":73,"d":"73.00"},200.89,"http://selleckchem.com/products/efaproxiral-sodium.html","C20H23NO4.Na","Sodium salt","RSR13 Sodium","[Na+].CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(OC(C)(C)C([O-])=O)C=C2)C",2.408,2,1,6]
["S4265","Nicaraven","g5","L3900-17","in 10mM DMSO","Others","Others","Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.",284.31,"79455-30-4",{"v":57,"d":"57.00"},200.49,{"v":57,"d":"57.00"},200.49,"http://selleckchem.com/products/nicaraven.html","C15H16N4O2","free base","N/A","CC(CNC(=O)C1=CN=CC=C1)NC(=O)C2=CN=CC=C2",-0.029,4,2,5]
["S4266","Brimonidine Tartrate","h5","L3900-17","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Brimonidine Tartrate(UK 1434 Tartrate) is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.",442.22,"70359-46-5",{"v":88,"d":"88.00"},{"v":199,"d":"199.00"},{"v":75,"d":"75.00"},{"v":169.6,"d":"169.60"},"http://selleckchem.com/products/brimonidine-tartrate.html","C15H16BrN5O6","Tartrate","UK 1434 Tartrate","OC(C(O)C(O)=O)C(O)=O.BrC1=C2N=CC=NC2=CC=C1NC3=NCCN3",-0.426,5,4,5]
["S4267","Diacerein","a6","L3900-17","in 10mM DMSO","Interleukins","Immunology & Inflammation","Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.",368.29,"13739-02-1",{"v":48,"d":"48.00"},130.33,"<1","N/A","http://selleckchem.com/products/diacerein.html","C19H12O8","free base","N/A","CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3OC(C)=O)C(O)=O)C2=O",1.973,7,0,5]
["S4268","Flufenamic acid","b6","L3900-17","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.",281.23,"530-78-9",{"v":56,"d":"56.00"},199.13,"<1","N/A","http://selleckchem.com/products/flufenamic-acid.html","C14H10F3NO2","free base","N/A","OC(=O)C1=CC=CC=C1NC2=CC=CC(=C2)C(F)(F)F",3.952,1,1,4]
["S4269","Vinorelbine ditartrate (KW-2307)","c6","L3900-17","in 10mM DMSO","Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.",1079.11,"125317-39-7",{"v":100,"d":"100.00"},92.67,{"v":100,"d":"100.00"},92.67,"http://selleckchem.com/products/vinorelbine-tartrate.html","C45H54N4O8.2C4H6O6","ditartrate","Nor-5'-anhydrovinblastine ditartrate,KW-2307","CCC1=CC2CN(C1)CC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC.OC(C(O)C(O)=O)C(O)=O.OC(C(O)C(O)=O)C(O)=O",{"v":-4,"d":"-4.000"},11,5,16]
["S4274","Rotigotine","d6","L3900-17","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Rotigotine(N-0923) is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.",315.47,"99755-59-6",{"v":63,"d":"63.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/rotigotine.html","C19H25NOS","free base","N-0923","CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O",4.986,0,1,6]
["S4277","Bambuterol HCl","e6","L3900-17","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride) is a potent β-adrenoceptor agonist, used in the treatment of asthma.",{"v":403.9,"d":"403.90"},"81732-46-9",{"v":80,"d":"80.00"},198.07,{"v":72,"d":"72.00"},178.26,"http://selleckchem.com/products/bambuterol-hci.html","C18H29N3O5.HCl","Hydrochloride","Bambuterol hydrochloride,KWD-2183 hydrochloride","Cl.CN(C)C(=O)OC1=CC(=CC(=C1)OC(=O)N(C)C)C(O)CNC(C)(C)C",2.109,4,2,8]
["S4278","Carteolol HCl","f6","L3900-17","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Carteolol HCl(Carteolol hydrochloride,OPC-1085 hydrochloride) is a β-adrenoceptor antagonist, used for the treatment of glaucoma.",328.83,"51781-21-6",{"v":65,"d":"65.00"},197.67,{"v":65,"d":"65.00"},197.67,"http://selleckchem.com/products/carteolol-hci.html","C16H25ClN2O3","Hydrochloride","Carteolol hydrochloride,OPC-1085 hydrochloride","Cl.CC(C)(C)NCC(O)COC1=C2CCC(=O)NC2=CC=C1",1.664,2,3,6]
["S4279","Demeclocycline HCl","g6","L3900-17","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Demeclocycline HCl(Demeclocycline hydrochloride) is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.",501.31,"64-73-3",{"v":100,"d":"100.00"},199.48,{"v":26,"d":"26.00"},51.86,"http://selleckchem.com/products/demeclocycline-hci.html","C21H21ClN2O8.HCl","Hydrochloride","Demeclocycline hydrochloride","Cl.CN(C)C1C2CC3C(O)C4=C(Cl)C=CC(=C4C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O)O",-0.053,3,5,2]
["S4281","Tasimelteon","h6","L3900-17","in 10mM DMSO","MT Receptor","Neuronal Signaling","Tasimelteon (BMS 214778, VEC 162) is a selective dual melatonin receptor (MT1/MT2) agonist with 2.1-4.4 times greater affinity for the MT2 receptor believed to mediate circadian rhythm phase-shifting (Ki = 0.0692 nM and Ki = 0.17 nM in NIH-3T3 and CHOeK1 cells, respectively), than for the MT1 receptor (Ki = 0.304 nM and Ki = 0.35 nM, respectively).",245.32,"609799-22-6",{"v":49,"d":"49.00"},199.74,{"v":-1,"d":"-1.00"},-4.08,"https://www.selleckchem.com/products/tasimelteon.html","C15H19NO2","free base","BMS 214778, VEC 162","CCC(=O)NCC1CC1C2=C3CCOC3=CC=C2",2.203,2,1,4]
["S4282","Nelfinavir (AG 1343) Mesylate","a7","L3900-17","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.",663.89,"159989-65-8",{"v":100,"d":"100.00"},150.63,"<1","N/A","http://selleckchem.com/products/nelfinavir-mesylate.html","C33H49N3O7S2","Mesylate","Viracept, AG1343","CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(O)CN3CC4CCCCC4CC3C(=O)NC(C)(C)C.C[S](O)(=O)=O",4.871,2,4,10]
["S4283","Cyclobenzaprine HCl","b7","L3900-17","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cyclobenzaprine HCl(Cyclobenzaprine hydrochloride) is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms; A 5-HT2 receptor antagonist.",311.85,"6202-23-9",{"v":62,"d":"62.00"},198.81,{"v":62,"d":"62.00"},198.81,"http://selleckchem.com/products/cyclobenzaprine-hci.html","C20H22ClN","Hydrochloride","Cyclobenzaprine hydrochloride","Cl.CN(C)CCC=C1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",4.709,0,0,3]
["S4284","Chloroprocaine HCl","c7","L3900-17","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Chloroprocaine HCl is a local anesthetic during surgical procedures.",307.22,"3858-89-7",{"v":61,"d":"61.00"},198.55,{"v":61,"d":"61.00"},198.55,"http://selleckchem.com/products/chloroprocaine-hci.html","C13H20Cl2N2O2","Hydrochloride","N/A","Cl.CCN(CC)CCOC(=O)C1=C(Cl)C=C(N)C=C1",2.821,2,1,7]
["S4285","Ospemifene","d7","L3900-17","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Ospemifene(FC-1271a) is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.",378.89,"128607-22-7",{"v":75,"d":"75.00"},197.95,"<1","N/A","http://selleckchem.com/products/ospemifene.html","C24H23ClO2","free base","FC-1271a","OCCOC1=CC=C(C=C1)\\C(=C(\\CCCl)C2=CC=CC=C2)C3=CC=CC=C3",{"v":5.62,"d":"5.620"},1,1,8]
["S4286","Anidulafungin (LY303366)","e7","L3900-17","in 10mM DMSO","Fungal","Microbiology","Anidulafungin (LY303366), an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.",1140.24,"166663-25-8",{"v":100,"d":"100.00"},{"v":87.7,"d":"87.70"},"<1","N/A","http://selleckchem.com/products/anidulafungin-ly303366.html","C58H73N7O17","free base","LY303366","CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(O)C(O)NC(=O)C5C(O)C(C)CN5C(=O)C(NC(=O)C(NC(=O)C6CC(O)CN6C(=O)C(NC4=O)C(C)O)C(O)C(O)C7=CC=C(O)C=C7)C(C)O",-0.358,8,14,14]
["S4289","Metoclopramide HCl","f7","L3900-17","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.",336.26,"7232-21-5",{"v":67,"d":"67.00"},199.25,{"v":67,"d":"67.00"},199.25,"http://selleckchem.com/products/metoclopramide-hcl.html","C14H23Cl2N3O2","Hydrochloride","Metoclopramide hydrochloride","Cl.CCN(CC)CCNC(=O)C1=CC(=C(N)C=C1OC)Cl",2.157,2,2,7]
["S4291","Labetalol HCl","g7","L3900-17","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Labetalol HCl(AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W) is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.",364.87,"32780-64-6",{"v":72,"d":"72.00"},197.33,{"v":8,"d":"8.00"},21.93,"http://selleckchem.com/products/labetalol-hcl.html","C19H25ClN2O3","Hydrochloride","AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W","Cl.CC(CCC1=CC=CC=C1)NCC(O)C2=CC(=C(O)C=C2)C(N)=O",2.737,1,4,8]
["S4292","Diphenidol HCl","h7","L3900-17","in 10mM DMSO","AChR","Neuronal Signaling","Diphenidol HCl(Diphenidol hydrochloride) is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.",345.91,"3254-89-5",{"v":69,"d":"69.00"},199.47,{"v":13,"d":"13.00"},37.58,"http://selleckchem.com/products/diphenidol-hcl.html","C21H28ClNO","Hydrochloride","Diphenidol hydrochloride","Cl.OC(CCCN1CCCCC1)(C2=CC=CC=C2)C3=CC=CC=C3",4.774,0,0,6]
["S4293","Promethazine HCl","a8","L3900-17","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Promethazine HCl is a potent histamine H1 receptor antagonist, used as a sedative and antiallergic medication.",320.88,"58-33-3",{"v":64,"d":"64.00"},199.45,{"v":64,"d":"64.00"},199.45,"http://selleckchem.com/products/promethazine-hcl.html","C17H21ClN2S","Hydrochloride","N/A","Cl.CC(CN1C2=CC=CC=C2SC3=C1C=CC=C3)N(C)C",4.772,0,0,3]
["S4294","Procainamide HCl","b8","L3900-17","in 10mM DMSO","DNA Methyltransferase,Sodium Channel","Transmembrane Transporters","Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.",271.79,"614-39-1",{"v":54,"d":"54.00"},198.68,{"v":54,"d":"54.00"},198.68,"http://selleckchem.com/products/procainamide-hcl.html","C13H22ClN3O","Hydrochloride","N/A","Cl.CCN(CC)CCNC(=O)C1=CC=C(N)C=C1",1.509,1,2,6]
["S4295","Meclofenamate Sodium","c8","L3900-17","in 10mM DMSO","COX,FTO","Neuronal Signaling","Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.",318.13,"6385-02-0",{"v":63,"d":"63.00"},198.03,{"v":63,"d":"63.00"},198.03,"http://selleckchem.com/products/meclofenamate-sodium.html","C14H11Cl2NO2.Na","Sodium Salt","CI 583","CC1=C(Cl)C(=C(Cl)C=C1)NC2=CC=CC=C2C(=O)O[Na]",4.915,2,1,4]
["S4296","Salmeterol Xinafoate","d8","L3900-17","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.",603.75,"94749-08-3",{"v":100,"d":"100.00"},165.63,"<1","N/A","http://selleckchem.com/products/salmeterol-xinafoate.html","C36H45NO7","xinafoate","GR 33343X xinafoate,Salmetedur","OCC1=C(O)C=CC(=C1)C(O)CNCCCCCCOCCCCC2=CC=CC=C2.OC(=O)C3=C(O)C4=CC=CC=C4C=C3",3.673,2,5,17]
["S4297","Mupirocin","e8","L3900-17","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.",500.62,"12650-69-0",{"v":100,"d":"100.00"},199.75,{"v":46,"d":"46.00"},91.89,"http://selleckchem.com/products/mupirocin.html","C26H44O9","free base","BRL-4910A,Pseudomonic acid","CC(O)C(C)C1OC1CC2COC(C\\C(C)=C\\C(=O)OCCCCCCCCC(O)=O)C(O)C2O",2.739,5,3,17]
["S4301","(R)-(+)-Atenolol HCl","f8","L3900-17","in 10mM DMSO","Adrenergic Receptor","Others","(R)-(+)-Atenolol binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists.",266.34,"56715-13-0",{"v":53,"d":"53.00"},198.99,{"v":18,"d":"18.00"},67.58,"http://selleckchem.com/products/atenolol.html","C9H16ClNO2","Hydrochloride","N/A","Cl.CC(=O)OC1CN2CCC1CC2",0.939,2,0,2]
["S4303","9-Aminoacridine","g8","L3900-17","in 10mM DMSO","Anti-infection","Microbiology","9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.",194.23,"90-45-9",{"v":38,"d":"38.00"},195.64,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/9-aminoacridine.html","C13H10N2","free base","Aminacrine","NC1=C2C=CC=CC2=NC3=CC=CC=C13",2.606,1,1,0]
["S4307","Auranofin","h8","L3900-17","in 10mM DMSO","Bacterial,Thioredoxin Reductase","Microbiology","Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.",678.48,"34031-32-8",{"v":100,"d":"100.00"},147.39,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/auranofin.html","C20H34AuO9PS","Free Base","Ridaura, SKF39162","CCP(|[Au]SC1OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O)(CC)CC",1.407,9,0,14]
["S4309","Bromocriptine Mesylate","a9","L3900-17","in 10mM DMSO","Others","Others","Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.",{"v":750.7,"d":"750.70"},"22260-51-1",{"v":100,"d":"100.00"},133.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bromocriptine-mesylate.html","C32H40BrN5O5.CH4O3S","Mesylate","N/A","CC(C)CC1N2C(=O)C(NC(=O)C3CN(C)C4CC5=C(Br)[NH]C6=C5C(=CC=C6)C4=C3)(OC2(O)C7CCCN7C1=O)C(C)C.C[S](O)(=O)=O",3.949,4,2,5]
["S4322","Disopyramide Phosphate","b9","L3900-17","in 10mM DMSO","Others","Others","Disopyramide (DISO) is a widely used Class 1a antiarrhythmic agent that is employed in the treatment of ventricular and supraventricular arrhythmias.",437.47,"22059-60-5",{"v":12,"d":"12.00"},27.43,{"v":87,"d":"87.00"},198.87,"http://www.selleckchem.com/products/disopyramide-phosphate.html","C21H32N3O5P","phosphate","N/A","CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C2=NC=CC=C2)C(C)C.O[P](O)(O)=O",2.949,2,1,8]
["S4331","Meclocycline Sulfosalicylate","c9","L3900-17","in 10mM DMSO","Others","Others","Meclocycline is a tetracycline antibiotic. Meclocycline sulfosalicylate prevents bacterial protein synthesis through 30S ribosome-mediated chain elongation and blocks amino-acyl tRNA A-site binding.",695.05,"73816-42-9",{"v":100,"d":"100.00"},143.87,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/meclocycline-sulfosalicylate.html","C22H21ClN2O8.C7H6O6S","sulfosalicylate","N/A","CN(C)C1C2C(O)C3C(=C)C4=C(C(=CC=C4Cl)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O.OC(=O)C5=C(O)C=CC(=C5)[S](O)(=O)=O",-2.767,4,6,4]
["S4336","Metaraminol Bitartrate","d9","L3900-17","in 10mM DMSO","Others","Others","N/A",317.29,"33402-03-8",{"v":63,"d":"63.00"},198.56,{"v":63,"d":"63.00"},198.56,"http://www.selleckchem.com/products/metaraminol-bitartrate.html","C13H19NO8","bitartrate","Metaradrine Bitartrate","CC(N)C(O)C1=CC=CC(=C1)O.OC(C(O)C(O)=O)C(O)=O",-3.582,2,5,5]
["S4338","Methoxamine HCl","e9","L3900-17","in 10mM DMSO","Others","Others","Methoxamine is an α1-adrenergic receptor agonist, it induces vasoconstriction of skin and splanchnic blood vessels.",247.72,"61-16-5",{"v":50,"d":"50.00"},201.84,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/methoxamine-hcl.html","C11H17NO3.HCl","Hydrochloride","Vasoxine HCl","Cl.COC1=CC(=C(OC)C=C1)C(O)C(C)N",1.151,2,2,4]
["S4343","Oxethazaine","f9","L3900-17","in 10mM DMSO","Others","Others","Oxethazaine is a strong local anaesthetic, which acts in a number of ways to numb the walls of the stomach and relieve the pain associated with hyperacidic conditions.",467.64,"126-27-2",{"v":87,"d":"87.00"},186.04,"<1","N/A","http://selleckchem.com/products/oxethazaine.html","C28H41N3O3","free base","Oxethacaine","CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)CC1=CC=CC=C1)C(C)(C)CC2=CC=CC=C2",3.286,2,1,12]
["S4345","Pentoxifylline","g9","L3900-17","in 10mM DMSO","PDE","Metabolism","Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.",278.31,"6493-05-6",{"v":55,"d":"55.00"},197.62,{"v":55,"d":"55.00"},197.62,"http://www.selleckchem.com/products/pentoxifylline.html","C13H18N4O3","Free Base","N/A","C[N]1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C",0.507,4,0,5]
["S4353","Terfenadine","h9","L3900-17","in 10mM DMSO","Calcium Channel,Caspase,Histamine Receptor,NCX,Potassium Channel","Transmembrane Transporters","Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.  Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.",471.67,"50679-08-8",{"v":94,"d":"94.00"},199.29,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/terfenadine.html","C32H41NO2","Free Base","N/A","CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",6.498,0,1,9]
["S4357","Tacrine HCl","a10","L3900-17","in 10mM DMSO","AChR","Neuronal Signaling","Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.",234.72,"1684-40-8",{"v":46,"d":"46.00"},195.98,{"v":46,"d":"46.00"},195.98,"http://www.selleckchem.com/products/tacrine-hcl.html","C13H14N2.HCl","hydrochlorid","N/A","Cl.NC1=C2C=CC=CC2=NC3=C1CCCC3",3.172,1,1,0]
["S4358","Pimozide","b10","L3900-17","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor,Dopamine Receptor,STAT","Neuronal Signaling","Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.",461.55,"2062-78-4",{"v":92,"d":"92.00"},199.33,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pimozide.html","C28H29F2N3O","Free Base","Orap, R6238","FC1=CC=C(C=C1)C(CCCN2CCC(CC2)N3C(=O)NC4=CC=CC=C34)C5=CC=C(F)C=C5",5.521,1,1,7]
["S4368","Carbenoxolone Sodium","c10","L3900-17","in 10mM DMSO","Others","Others","Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.",614.72,"7421-40-1",{"v":23,"d":"23.00"},37.42,{"v":100,"d":"100.00"},162.68,"http://www.selleckchem.com/products/carbenoxolone-sodium.html","C34H48Na2O7","disodiuM","N/A","[Na+].[Na+].CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C([O-])=O)OC(=O)CCC([O-])=O",2.933,3,0,6]
["S4373","Dicyclomine HCl","d10","L3900-17","in 10mM DMSO","Others","Others","Dicyclomine is an anticholinergic drug, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle).",345.95,"67-92-5",{"v":22,"d":"22.00"},63.59,{"v":69,"d":"69.00"},199.45,"http://www.selleckchem.com/products/dicyclomine-hcl.html","C19H36ClNO2","Hydrochloride","Dicycloverine HCl","Cl.CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2",5.487,2,0,8]
["S4376","Aceclidine HCl","e10","L3900-17","in 10mM DMSO","Others","Others","Aceclidine is a parasympathomimetic miotic agent used to decreases intraocular pressure.",205.68,"6109-70-2",{"v":41,"d":"41.00"},199.34,{"v":41,"d":"41.00"},199.34,"http://www.selleckchem.com/products/aceclidine-hcl.html","C9H16ClNO2","hydrochloride","N/A","Cl.CC(=O)OC1CN2CCC1CC2",0.939,2,0,2]
["S4377","Imipramine HCl","f10","L3900-17","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).",316.87,"113-52-0",{"v":63,"d":"63.00"},198.82,{"v":63,"d":"63.00"},198.82,"http://www.selleckchem.com/products/imipramine-hcl.html","C19H25ClN2","hydrochloride","Melipramine HCl,G 22355","Cl.CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.769,0,0,4]
["S4385","Fosfomycin Tromethamine","g10","L3900-17","in 10mM DMSO","Others","Others","Fosfomycin tromethamine is a phosphonic acid bactericidal agent with in vitro activity against most urinary tract pathogens.",259.19,"78964-85-9",{"v":51,"d":"51.00"},196.77,{"v":51,"d":"51.00"},196.77,"http://www.selleckchem.com/products/fosfomycin-tromethamine.html","C7H18NO7P","tromethamine","Phosphomycin Tromethamine, Phosphonomycin Tromethamine","CC1OC1[P](O)(O)=O.NC(CO)(CO)CO",-2.699,1,4,4]
["S4387","Bendroflumethiazide","h10","L3900-17","in 10mM DMSO","Others","Others","N/A",421.41,"73-48-3",{"v":85,"d":"85.00"},{"v":201.7,"d":"201.70"},"N/A","N/A","http://selleckchem.com/products/bendroflumethiazide.html","C15H14F3N3O4S2","sulfonamide","Bendrofluazide","N[S](=O)(=O)C1=CC2=C(NC(CC3=CC=CC=C3)N[S]2(=O)=O)C=C1C(F)(F)F","N/A","N/A","N/A","N/A"]
["S4415","Misoprostol","a11","L3900-17","in 10mM DMSO","PGES,Prostaglandin Receptor","GPCR & G Protein","Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.",382.54,"59122-46-2",{"v":76,"d":"76.00"},198.67,"N/A","N/A","http://selleckchem.com/products/misoprostol.html","C22H38O5","Prostaglandin E1","SC-29333","CCCCC(C)(O)C/C=C/C1C(O)CC(=O)C1CCCCCCC(=O)OC","N/A","N/A","N/A","N/A"]
["S4420","Mefloquine HCl","b11","L3900-17","in 10mM DMSO","Anti-infection","Microbiology","Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.",414.77,"51773-92-3",{"v":82,"d":"82.00"},{"v":197.7,"d":"197.70"},"<1","N/A","http://selleckchem.com/products/mefloquine-hcl.html","C17H17ClF6N2O","Hydrochloride","Mefloquin hydrochloride","Cl.OC(C1CCCCN1)C2=CC(=NC3=C(C=CC=C23)C(F)(F)F)C(F)(F)F",4.684,1,2,4]
["S4502","Eltrombopag","c11","L3900-17","in 10mM DMSO","TpoR","Immunology & Inflammation","Eltrombopag (SB-497115), a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP).",442.47,"496775-61-2",{"v":26,"d":"26.00"},58.76,"<1","N/A","http://selleckchem.com/products/eltrombopag.html","C25H22N4O4","Free Base","SB-497115","CC1=CC=C(C=C1C)N2N=C(C)C(=N/NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(O)=O)/C2=O",4.702,4,2,5]
["S4504","6-Mercaptopurine (6-MP) Monohydrate","d11","L3900-17","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",170.19,"6112-76-1",{"v":34,"d":"34.00"},199.78,"<1","N/A","http://selleckchem.com/products/6-mercaptopurine-6-mp-monohydrate.html","C5H6N4OS","free base","N/A","O.S=C1N=CNC2=C1[NH]C=N2",{"v":0.16,"d":"0.160"},2,2,0]
["S4505","Vinblastine (NSC-49842) sulfate","e11","L3900-17","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1","N/A","http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4506","Acetazolamide","f11","L3900-17","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).",222.25,"59-66-5",{"v":44,"d":"44.00"},197.98,"<1","N/A","http://selleckchem.com/products/acetazolamide.html","C4H6N4O3S2","free base","Diamox","CC(=O)NC1=NN=C(S1)[S](N)(=O)=O",-1.329,5,2,2]
["S4507","17-Hydroxyprogesterone","g11","L3900-17","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.",330.46,"68-96-2",{"v":66,"d":"66.00"},199.72,"<1","N/A","http://selleckchem.com/products/17-hydroxyprogesterone.html","C21H30O3","free base","N/A","CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",3.124,2,0,1]
["S4514","Acetylleucine","h11","L3900-17","in 10mM DMSO","Others","Others","Acetylleucine (N-acetyl-L-leucine) is a drug used in the treatment of vertigo.",173.21,"99-15-0",{"v":34,"d":"34.00"},196.29,"<1","N/A","http://selleckchem.com/products/acetylleucine.html","C8H15NO3","free base","N-acetyl-L-leucine","CC(C)CC(NC(C)=O)C(O)=O",0.571,2,1,4]
["S4515","Ademetionine disulfate tosylate","a2","L3900-18","in 10mM DMSO","Anti-infection","Immunology & Inflammation","Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.",{"v":766.8,"d":"766.80"},"97540-22-2",{"v":79,"d":"79.00"},103.03,{"v":79,"d":"79.00"},103.03,"http://selleckchem.com/products/ademetionine-disulfate-tosylate.html","C22H34N6O16S4","disulfate tosylate","N/A","C[S+](CCC(N)C([O-])=O)CC1OC(C(O)C1O)[N]2C=NC3=C(N)N=CN=C23.CC4=CC=C(C=C4)[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-2.814,4,4,8]
["S4516","(+)-Camphor","b2","L3900-18","in 10mM DMSO","Fungal,TRP Channel","Transmembrane Transporters","Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1  and TRPV3.",152.23,"464-49-3",{"v":30,"d":"30.00"},197.07,"<1","N/A","http://selleckchem.com/products/positive-rotation-camphor.html","C10H16O","free base","D-(+)-camphor, (1R)-(+)-camphor","CC1(C)C2CCC1(C)C(=O)C2",2.075,1,0,0]
["S4517","Cefotaxime sodium","c2","L3900-18","in 10mM DMSO","Antibiotics,Antibiotics for Plant Cell Culture,Bacterial","Microbiology","Cefotaxime sodium(HR-756) salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria.",477.45,"64485-93-4",{"v":95,"d":"95.00"},198.97,{"v":95,"d":"95.00"},198.97,"http://selleckchem.com/products/cefotaxime-sodium.html","C16H17N5O7S2.Na","Sodium Salt","HR-756","[Na+].CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)COC(C)=O)C3=CSC(=N3)N",-2.384,7,2,8]
["S4521","DEET","d2","L3900-18","in 10mM DMSO","Anti-infection","Microbiology","DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.",191.27,"134-62-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/deet.html","C12H17NO","free base","N,N-Diethyl-meta-toluamide, diethyltoluamide","CCN(CC)C(=O)C1=CC(=CC=C1)C",2.427,1,0,3]
["S4527","Fenofibric acid","e2","L3900-18","in 10mM DMSO","PPAR","Metabolism","Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.",318.75,"42017-89-0",{"v":63,"d":"63.00"},197.65,{"v":63,"d":"63.00"},197.65,"http://selleckchem.com/products/fenofibric-acid.html","C17H15ClO4","free base","NSC 281318, Trilipix, FNF acid","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C(O)=O",4.159,3,0,5]
["S4528","Furazolidone","f2","L3900-18","in 10mM DMSO","Bacterial","Microbiology","Furazolidone(Furoxone) is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.",225.16,"67-45-8",{"v":45,"d":"45.00"},199.86,"<1","N/A","http://selleckchem.com/products/furazolidone.html","C8H7N3O5","free base","Furoxone","[O-][N+](=O)C1=CC=C(O1)\\C=N\\N2CCOC2=O",{"v":1.1,"d":"1.100"},4,0,3]
["S4532","Iopamidol","g2","L3900-18","in 10mM DMSO","Others","Others","Iopamidol (Iopamiro, Isovue, Iopamiron, Niopam, Solutrast,B-15000,SQ-13396) is a non-ionic, water-soluble radiographic contrast agent.",777.09,"60166-93-0",{"v":100,"d":"100.00"},128.69,{"v":100,"d":"100.00"},128.69,"http://selleckchem.com/products/iopamidol.html","C17H22I3N3O8","free base","Iopamiro, Isovue, Iopamiron, Niopam, Solutrast,B-15000,SQ-13396","CC(O)C(=O)NC1=C(I)C(=C(I)C(=C1I)C(=O)NC(CO)CO)C(=O)NC(CO)CO",-1.187,3,8,10]
["S4535","Methylene Blue","h2","L3900-18","in 10mM DMSO","Dyes,Guanylate Cyclase,Microtubule Associated","GPCR & G Protein","Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.",319.85,"61-73-4",{"v":63,"d":"63.00"},196.97,{"v":63,"d":"63.00"},196.97,"http://selleckchem.com/products/methylene-blue.html","C16H18ClN3S","free base","Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015","[Cl-].CN(C)C1=CC2=C(C=C1)N=C3C=CC(C=C3S2)=[N+](C)C",0.369,1,0,1]
["S4536","Nitrofurantoin","a3","L3900-18","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.",238.16,"67-20-9",{"v":47,"d":"47.00"},197.35,"<1","N/A","http://selleckchem.com/products/nitrofurantoin.html","C8H6N4O5","free base","Macrodantin, Furadantine, Furadonine","[O-][N+](=O)C1=CC=C(O1)/C=N/N2CC(=O)NC2=O",0.105,4,1,3]
["S4538","Pantoprazole sodium","b3","L3900-18","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",405.35,"138786-67-1",{"v":81,"d":"81.00"},199.83,{"v":81,"d":"81.00"},199.83,"http://selleckchem.com/products/pantoprazole-sodium.html","C16H14F2N3NaO4S","Free Base","SKF96022 sodium, BY-1023 sodium","[Na+].COC1=CC=NC(=C1OC)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F",2.883,6,0,7]
["S4539","Salicylic acid","c3","L3900-18","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1","N/A","http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4541","Triclosan","d3","L3900-18","in 10mM DMSO","Bacterial","Microbiology","Triclosan (Irgasan, Cloxifenolum) is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.",289.54,"3380-34-5",{"v":57,"d":"57.00"},196.86,"<1","N/A","http://selleckchem.com/products/triclosan.html","C12H7Cl3O2","free base","Irgasan, Cloxifenolum","OC1=CC(=CC=C1OC2=CC=C(Cl)C=C2Cl)Cl",5.141,1,1,2]
["S4542","Trihexyphenidyl hydrochloride","e3","L3900-18","in 10mM DMSO","AChR","Neuronal Signaling","Trihexyphenidyl hydrochloride (Benzhexol, Artane) is an antiparkinsonian agent of the antimuscarinic class.",337.93,"52-49-3",{"v":7,"d":"7.00"},20.71,"<1","N/A","http://selleckchem.com/products/trihexyphenidyl-hydrochloride.html","C20H31NO.HCl","hydrochloride","Benzhexol hydrochloride, Artane hydrochloride","Cl.OC(CCN1CCCCC1)(C2CCCCC2)C3=CC=CC=C3",4.799,0,0,5]
["S4543","Trimetazidine dihydrochloride","f3","L3900-18","in 10mM DMSO","FAO","Metabolism","Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.",339.26,"13171-25-0",{"v":67,"d":"67.00"},197.49,{"v":67,"d":"67.00"},197.49,"http://selleckchem.com/products/trimetazidine-dihydrochloride.html","C14H22N2O3.2HCl","Dihydrochloride","Yoshimilon, Kyurinett, Vastarel F","Cl.Cl.COC1=C(OC)C(=C(CN2CCNCC2)C=C1)OC",2.039,3,1,5]
["S4544","Urethane","g3","L3900-18","in 10mM DMSO","Bacterial","Microbiology","Urethane (Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane) is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis.",89.09,"51-79-6",{"v":17,"d":"17.00"},190.82,{"v":17,"d":"17.00"},190.82,"http://selleckchem.com/products/urethane.html","C3H7NO2","free base","Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane","CCOC(N)=O",0.159,2,1,2]
["S4547","8-Hydroxyquinoline","h3","L3900-18","in 10mM DMSO","Bacterial","Microbiology","8-Hydroxyquinoline (8-Oxychinolin, 8-Quinolinol, Oxine) is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes.",145.16,"148-24-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/8-hydroxyquinoline.html","C9H7NO","Free Base","8-Oxychinolin, 8-Quinolinol, Oxine","OC1=CC=CC2=CC=CN=C12",1.774,1,1,0]
["S4548","Aminoguanidine hydrochloride","a4","L3900-18","in 10mM DMSO","NOS","Immunology & Inflammation","Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.",110.55,"1937-19-5",{"v":22,"d":"22.00"},{"v":199,"d":"199.00"},{"v":22,"d":"22.00"},{"v":199,"d":"199.00"},"http://selleckchem.com/products/aminoguanidine-hydrochloride.html","CH6N4.HCl","hydrochloride","Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine","Cl.NNC(N)=N",-1.098,0,3,1]
["S4550","Azelaic acid","b4","L3900-18","in 10mM DMSO","Bacterial","Microbiology","Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.",188.22,"123-99-9",{"v":37,"d":"37.00"},196.58,{"v":37,"d":"37.00"},196.58,"http://selleckchem.com/products/azelaic-acid.html","C9H16O4","free base","Nonanedioic acid, Finacea, Azelex, Anchoic acid","OC(=O)CCCCCCCC(O)=O",1.921,2,0,8]
["S4552","Bithionol","c4","L3900-18","in 10mM DMSO","cAMP","GPCR & G Protein","Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.",356.05,"97-18-7",{"v":71,"d":"71.00"},199.41,"<1","N/A","http://selleckchem.com/products/bithionol.html","C12H6Cl4O2S","free base","Actamer","OC1=C(Cl)C=C(Cl)C=C1SC2=C(O)C(=CC(=C2)Cl)Cl",6.122,0,2,2]
["S4564","Diethylcarbamazine citrate","d4","L3900-18","in 10mM DMSO","Parasite","Microbiology","Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria and is highly specific for several parasites and does not contain any toxic metallic elements.",391.42,"1642-54-2",{"v":78,"d":"78.00"},199.27,{"v":78,"d":"78.00"},199.27,"http://selleckchem.com/products/diethylcarbamazine-citrate.html","C10H21N3O.C6H8O7","citrate","N/A","CCN(CC)C(=O)N1CCN(C)CC1.OC(=O)CC(O)(CC(O)=O)C(O)=O",-3.918,4,0,7]
["S4569","Fluphenazine dihydrochloride","e4","L3900-18","in 10mM DMSO","Dopamine Receptor","GPCR & G Protein","Fluphenazine dihydrochloride (Prolixin) is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits  Histamine H1 Receptor.",510.44,"146-56-5",{"v":100,"d":"100.00"},195.91,{"v":100,"d":"100.00"},195.91,"http://selleckchem.com/products/fluphenazine-dihydrochloride.html","C22H26F3N3OS.2HCl","dihydrochloride","Prolixin","Cl.Cl.OCCN1CCN(CCCN2C3=C(SC4=CC=C(C=C24)C(F)(F)F)C=CC=C3)CC1",5.199,0,1,7]
["S4570","Halothane","f4","L3900-18","in 10mM DMSO","Others","Others","Halothane (Narcotane) is a general inhalation anesthetic used for induction and maintenance of general anesthesia.",197.38,"151-67-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/halothane.html","C2HBrClF3","free base","Narcotane","FC(F)(F)C(Cl)Br",2.509,0,0,1]
["S4578","Tyloxapol","g4","L3900-18","in 10mM DMSO","Others","Others","Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surfactant to aid liquefaction, removal of mucopurulent and bronchopulmonary secretions. It also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.","N/A","25301-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/tyloxapol.html","(C14H22O.C2H4O.CH2O)x","free base","Triton WR1339","CC1=CC(=CC(=C1OCCO)CC2=C(OCCO)C(=CC(=C2)C(C)(C)CC(C)(C)C)CC3=C(OCCO)C=CC(=C3)C(C)(C)CC(C)(C)C)C(C)(C)CC(C)(C)C",{"v":16.58,"d":"16.580"},3,3,22]
["S4583","Butamben","h4","L3900-18","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.",193.24,"94-25-7",{"v":38,"d":"38.00"},196.65,{"v":38,"d":"38.00"},196.65,"http://selleckchem.com/products/butamben.html","C11H15NO2","free base","Butyl 4-aminobenzoate","CCCCOC(=O)C1=CC=C(N)C=C1",2.267,2,1,5]
["S4588","Docusate Sodium","a5","L3900-18","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Docusate Sodium (Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate) is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.",444.56,"577-11-7",{"v":88,"d":"88.00"},197.95,{"v":18,"d":"18.00"},40.49,"http://selleckchem.com/products/docusate-sodium.html","C20H37O7S.Na","sodium salt","Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate","[Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)[S]([O-])(=O)=O",3.172,4,0,18]
["S4589","Amodiaquine dihydrochloride dihydrate","b5","L3900-18","in 10mM DMSO","Histone Methyltransferase,HNMT,Transferase","Epigenetics","Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.",464.81,"6398-98-7",{"v":92,"d":"92.00"},197.93,{"v":29,"d":"29.00"},62.39,"http://selleckchem.com/products/amodiaquine-dihydrochloride-dihydrate.html","C20H22ClN3O.2HCl.2H2O","dihydrochloride dihydrate","N/A","O.O.Cl.Cl.CCN(CC)CC1=CC(=CC=C1O)NC2=C3C=CC(=CC3=NC=C2)Cl",5.109,1,2,6]
["S4590","Dithranol","c5","L3900-18","in 10mM DMSO","Others","Others","Dithranol (Anthralin, cignoline, 1,8,9-trihydroxyanthracene) is one of the most important local therapeutic agents against the common skin disease, psoriasis.",226.23,"1143-38-0",{"v":7,"d":"7.00"},30.94,"N/A","N/A","http://selleckchem.com/products/dithranol.html","C14H10O3","free base","Anthralin, cignoline, 1,8,9-trihydroxyanthracene","OC1=CC=CC2=C1C(=O)C3=C(C2)C=CC=C3O",2.894,1,2,0]
["S4593","Chlormadinone acetate","d5","L3900-18","in 10mM DMSO","5-alpha Reductase,Androgen Receptor","Endocrinology & Hormones","Chlormadinone acetate (Gestafortin) is a steroidal progestin with additional antiandrogen and antigonadotropic effects, used often in combinations as an oral contraceptive. Its half-life is about 34-38 hours.",404.93,"302-22-7",{"v":27,"d":"27.00"},66.68,"<1","N/A","http://selleckchem.com/products/chlormadinone-acetate.html","C23H29ClO4","free base","Gestafortin","CC(=O)OC1(CCC2C3C=C(Cl)C4=CC(=O)CCC4(C)C3CCC12C)C(C)=O",3.428,4,0,3]
["S4595","Cefazolin Sodium","e5","L3900-18","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefazolin Sodium (cefazoline, cephazolin, Ancef) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.",476.49,"27164-46-1",{"v":95,"d":"95.00"},199.37,{"v":95,"d":"95.00"},199.37,"http://selleckchem.com/products/cefazolin-sodium.html","C14H14N8O4S3.Na","sodium","cefazoline sodium, cephazolin sodium, Ancef","[Na+].CC1=NN=C(SCC2=C(N3C(SC2)C(NC(=O)C[N]4C=NN=N4)C3=O)C([O-])=O)S1",-2.807,7,1,7]
["S4596","Cefixime","f5","L3900-18","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Cefixime (Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635) is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin.",453.45,"79350-37-1",{"v":90,"d":"90.00"},198.48,"<1","N/A","http://selleckchem.com/products/cefixime.html","C16H15N5O7S2","free base","Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635","NC1=NC(=CS1)C(=N/OCC(O)=O)/C(=O)NC2C3SCC(=C(N3C2=O)C(O)=O)C=C",-0.651,7,2,8]
["S4597","Lercanidipine hydrochloride","g5","L3900-18","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lercanidipine is a calcium channel blocker of the dihydropyridine class.",648.19,"132866-11-6",{"v":66,"d":"66.00"},101.82,"<1","N/A","http://selleckchem.com/products/lercanidipine-hydrochloride.html","C36H41N3O6.HCl","hydrochloride","Zanidip (hydrochloride), Masnidipine (hydrochloride)","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C",6.514,4,1,14]
["S4600","Benzyl alcohol","h5","L3900-18","in 10mM DMSO","Others","Others","Benzyl alcohol (Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol) is used as a local anesthetic. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.",108.14,"100-51-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/benzyl-alcohol.html","C7H8O","free base","Phenylmethanol, Benzenemethanol, Phenylcarbinol, Benzoyl alcohol","OCC1=CC=CC=C1",1.225,0,1,1]
["S4601","Clioquinol","a6","L3900-18","in 10mM DMSO","Fungal","Microbiology","Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.",{"v":305.5,"d":"305.50"},"130-26-7",{"v":61,"d":"61.00"},199.67,"<1","N/A","http://selleckchem.com/products/5-chloro-8-hydroxy-7-iodoquinoline.html","C9H5ClINO","free base","Iodochlorhydroxyquin, Chinoform","OC1=C(I)C=C(Cl)C2=CC=CN=C12",3.016,1,1,0]
["S4603","Gallic acid","b6","L3900-18","in 10mM DMSO","ROS","Immunology & Inflammation","Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.",170.12,"149-91-7",{"v":34,"d":"34.00"},199.86,{"v":7,"d":"7.00"},41.15,"http://selleckchem.com/products/gallic-acid.html","C7H6O5","free base","3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid","OC(=O)C1=CC(=C(O)C(=C1)O)O",0.733,1,3,1]
["S4604","Levofloxacin hydrate","c6","L3900-18","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Levofloxacin (Levaquin, Tavanic, Quixin, Iquix, Cravit) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).",370.38,"138199-71-0",{"v":74,"d":"74.00"},199.79,{"v":5,"d":"5.00"},{"v":13.5,"d":"13.50"},"http://selleckchem.com/products/levofloxacin-hydrate.html","C18H20FN3O4.1/2H2O","hydrate","Levofloxacin hemihydrate, Levaquin hydrate, Tavanic hydrate, Quixin hydrate, Iquix hydrate, Cravit hydrate","CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCN(C)CC4)F",{"v":-0.64,"d":"-0.640"},3,0,2]
["S4609","Diflunisal","d6","L3900-18","in 10mM DMSO","COX","Neuronal Signaling","Diflunisal (Dolobid, Dolobis, Flovacil, Fluniget,MK-647) is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.",{"v":250.2,"d":"250.20"},"22494-42-4",{"v":50,"d":"50.00"},199.84,"<1","N/A","http://selleckchem.com/products/diflunisal.html","C13H8F2O3","free base","Dolobid, Dolobis, Flovacil, Fluniget,MK-647","OC(=O)C1=C(O)C=CC(=C1)C2=C(F)C=C(F)C=C2",3.147,1,1,2]
["S4610","Mebendazole","e6","L3900-18","in 10mM DMSO","Parasite","Microbiology","Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.",295.29,"31431-39-7",{"v":6,"d":"6.00"},20.32,"<1","N/A","http://selleckchem.com/products/mebendazole.html","C16H13N3O3","free base","Vermox, Telmin, Pantelmin, Mebenvet","COC(=O)NC1=NC2=C([NH]1)C=CC(=C2)C(=O)C3=CC=CC=C3",3.055,4,2,4]
["S4618","Fenoldopam mesylate","f6","L3900-18","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Fenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.",401.86,"67227-57-0",{"v":80,"d":"80.00"},199.07,"<1","N/A","http://selleckchem.com/products/fenoldopam-mesylate.html","C16H16ClNO3.CH4O3S","mesylate","SKF 82526 (mesylate), Fenoldopam methanesulfonate, Corlopam mesylate","C[S](O)(=O)=O.OC1=CC=C(C=C1)C2CNCCC3=C(Cl)C(=C(O)C=C23)O",2.639,0,4,1]
["S4619","Itopride hydrochloride","g6","L3900-18","in 10mM DMSO","AChR","Neuronal Signaling","Itopride hydrochloride (Ganaton, HSR803) is an AChE inhibitor. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.",394.89,"122892-31-3",{"v":78,"d":"78.00"},197.52,{"v":78,"d":"78.00"},197.52,"http://selleckchem.com/products/itopride-hydrochloride.html","C20H26N2O4.HCl","hydrochloride","Ganaton, HSR803","Cl.COC1=CC=C(C=C1OC)C(=O)NCC2=CC=C(OCCN(C)C)C=C2",3.093,4,1,9]
["S4620","Cefuroxime sodium","h6","L3900-18","in 10mM DMSO","β-lactamase","Microbiology","Cefuroxime Sodium is a cephalosporin effective against gram-positive and gram-negative bacteria with resistance to β-lactamase.",446.37,"56238-63-2",{"v":89,"d":"89.00"},199.39,{"v":89,"d":"89.00"},199.39,"http://selleckchem.com/products/cefuroxime-sodium.html","C16H16N4O8S.Na","sodium","N/A","[Na+].CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)COC(N)=O)C3=CC=CO3",-1.877,7,2,8]
["S4622","3,4-Diaminopyridine","a7","L3900-18","in 10mM DMSO","Others","Others","3,4-Diaminopyridine (Amifampridine, pyridine-3,4-diamine) blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases.",109.13,"54-96-6",{"v":22,"d":"22.00"},201.59,{"v":7,"d":"7.00"},64.14,"http://www.selleck.cn/products/3-4-diaminopyridine.html","C5H7N3","free base","Amifampridine, pyridine-3,4-diamine","NC1=C(N)C=NC=C1",-0.814,1,2,0]
["S4625","Alcaftadine","b7","L3900-18","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Alcaftadine (Lastacaft, R89674) is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.",307.39,"147084-10-4",{"v":28,"d":"28.00"},91.09,"<1","N/A","http://selleckchem.com/products/alcaftadine.html","C19H21N3O","free base","Lastacaft, R89674","CN1CCC(CC1)=C2C3=C(CC[N]4C(=CN=C24)C=O)C=CC=C3",2.831,2,0,1]
["S4626","Ethosuximide","c7","L3900-18","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ethosuximide(Zarontin) is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.",141.17,"77-67-8",{"v":28,"d":"28.00"},198.34,{"v":28,"d":"28.00"},198.34,"http://selleckchem.com/products/ethosuximide.html","C7H11NO2","free base","Zarontin","CCC1(C)CC(=O)NC1=O",0.543,2,1,1]
["S4630","Diazoxide","d7","L3900-18","in 10mM DMSO","ADC Cytotoxin,Potassium Channel","Transmembrane Transporters","Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.",230.67,"364-98-7",{"v":46,"d":"46.00"},199.42,"<1","N/A","http://selleckchem.com/products/diazoxide.html","C8H7ClN2O2S","free base","Sch-6783, SRG-95213, Proglycem","CC1=NC2=CC=C(Cl)C=C2[S](=O)(=O)N1",1.196,3,1,0]
["S4631","Prochlorperazine dimaleate salt","e7","L3900-18","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist.",606.09,"84-02-6",{"v":74,"d":"74.00"},122.09,"<1","N/A","http://selleckchem.com/products/prochlorperazine.html","C20H24ClN3S.C8H8O8","dimaleate","Prochlorperazin, Compazine, Capazine, Stemetil","CN1CCN(CCCN2C3=C(SC4=C2C=C(Cl)C=C4)C=CC=C3)CC1.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",-1.295,4,0,8]
["S4633","Isosorbide Mononitrate","f7","L3900-18","in 10mM DMSO","Others","Others","Isosorbide mononitrate (Elantan, Monoket, Mononit, Imdur, Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.",191.14,"16051-77-7",{"v":38,"d":"38.00"},198.81,{"v":38,"d":"38.00"},198.81,"http://selleckchem.com/products/isosorbide-mononitrate.html","C6H9NO6","Free Base","Isosorbide-5-mononitrate, Elantan, Monoket, Mononit, Imdur, Corangin","OC1COC2C(COC12)O[N+]([O-])=O",1.003,3,1,2]
["S4634","Sodium sulfadiazine","g7","L3900-18","in 10mM DMSO","Bacterial","Microbiology","Sodium Sulfadiazine (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.",272.26,"547-32-0",{"v":9,"d":"9.00"},33.06,{"v":54,"d":"54.00"},198.34,"http://selleckchem.com/products/sodium-sulfadiazine.html","C10H10N4O2S.Na","Sodium salt","Sulfadiazin-natrium","NC1=CC=C(C=C1)[S](=O)(=O)N([Na])C2=NC=CC=N2",0.417,4,1,3]
["S4635","Cyproheptadine hydrochloride sesquihydrate","h7","L3900-18","in 10mM DMSO","5-HT Receptor,SETD","Neuronal Signaling","Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.",350.88,"41354-29-4",{"v":70,"d":"70.00"},{"v":199.5,"d":"199.50"},"<1","N/A","https://www.selleckchem.com/products/cyproheptadine-hydrochloride-sesquihydrate.html","C21H21N.HCl.3/2H2O","hydrochloride sesquihydrate","Periactin hydrochloride, Peritol","O.O.O.Cl.Cl.CN1CCC(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C24.CN5CCC(CC5)=C6C7=CC=CC=C7C=CC8=CC=CC=C68",5.478,0,0,0]
["S4636","Teneligliptin hydrobromide","a8","L3900-18","in 10mM DMSO","DPP","Proteases","Teneligliptin (Teneligliptin hydrobromide anhydrous) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.",628.86,"906093-29-6",{"v":100,"d":"100.00"},159.02,{"v":100,"d":"100.00"},159.02,"http://selleckchem.com/products/teneligliptin-hydrobromide.html","C22H30N6OS.5/2HBr","hydrobromide","Teneligliptin hydrobromide anhydrous","CC1=N[N](C2=CC=CC=C2)C(=C1)N3CCN(CC3)C4CNC(C4)C(=O)N5CCSC5",2.645,2,1,4]
["S4637","Prasugrel Hydrochloride","b8","L3900-18","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Prasugrel hydrochloride (Prasugrel HCl, LY640315,PCR 4099 Hydrochloride)  is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.",{"v":409.9,"d":"409.90"},"389574-19-0",{"v":46,"d":"46.00"},112.22,"<1","N/A","http://selleckchem.com/products/prasugrel-hydrochloride.html","C20H20FNO3S.HCl","hydrochloride","Prasugrel HCl, LY640315,PCR 4099 Hydrochloride","Cl.CC(=O)OC1=CC2=C(CCN(C2)C(C(=O)C3CC3)C4=C(F)C=CC=C4)S1",4.183,3,0,6]
["S4638","Desogestrel","c8","L3900-18","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.",310.47,"54024-22-5",{"v":62,"d":"62.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/desogestrel.html","C22H30O","free base","Cerazette, Desogen, Desogestrelum, Org-2969","CCC12CC(=C)C3C(CCC4=CCCCC34)C1CCC2(O)C#C",5.828,0,0,1]
["S4640","Lesinurad","d8","L3900-18","in 10mM DMSO","OAT","Transmembrane Transporters","Lesinurad (RDEA-594) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in combination with xanthine oxidase inhibitors. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.",404.28,"878672-00-5",{"v":80,"d":"80.00"},197.88,"<1","N/A","http://selleckchem.com/products/lesinurad.html","C17H14BrN3O2S","free base","RDEA 594, RDEA-594, RDEA594","OC(=O)CSC1=NN=C(Br)[N]1C2=C3C=CC=CC3=C(C=C2)C4CC4",4.257,3,0,5]
["S4641","Tedizolid Phosphate","e8","L3900-18","in 10mM DMSO","Antibiotics","Microbiology","Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.",450.32,"856867-55-5",{"v":22,"d":"22.00"},48.85,"<1","N/A","http://selleckchem.com/products/tedizolid-phosphate.html","C17H16FN6O6P","free base","TR-701FA","C[N]1N=NC(=N1)C2=NC=C(C=C2)C3=CC=C(C=C3F)N4CC(CO[P](O)(O)=O)OC4=O",1.712,7,0,6]
["S4646","Ciclesonide","f8","L3900-18","in 10mM DMSO","COVID-19,Glucocorticoid Receptor","Endocrinology & Hormones","Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.",540.69,"126544-47-6",{"v":100,"d":"100.00"},184.95,"<1","N/A","http://selleckchem.com/products/ciclesonide.html","C32H44O7","free base","Alvesco, Omnaris, RPR251526, Zetonna","CC(C)C(=O)OCC(=O)C12OC(OC1CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC23C)C6CCCCC6",4.696,6,1,6]
["S4648","Dantrolene sodium hemiheptahydrate","g8","L3900-18","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.",399.29,"24868-20-0",{"v":14,"d":"14.00"},35.06,"<1","N/A","https://www.selleckchem.com/products/dantrolene-sodium-s4648.html","C14H9N4O5.7/2H2O.Na","Sodium salt hemiheptahydrate","Dantrolene sodium salt, Dantrium, Sodium dantrolene","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4649","Atipamezole hydrochloride","h8","L3900-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Atipamezole (Antisedan, MPV1248) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.",248.75,"104075-48-1",{"v":12,"d":"12.00"},48.24,{"v":21,"d":"21.00"},84.42,"http://selleckchem.com/products/atipamezole-hydrochloride.html","C14H16N2.HCl","hydrochloride","Antisedan, MPV-1248 hydrochloride, MPV1248 hydrochloride, MPV 1248 hydrochloride","Cl.CCC1(CC2=C(C1)C=CC=C2)C3=C[NH]C=N3",3.531,1,1,2]
["S4650","Atipamezole","a9","L3900-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.",212.29,"104054-27-5",{"v":42,"d":"42.00"},197.84,"<1","N/A","http://selleckchem.com/products/atipamezole.html","C14H16N2","Free Base","MPV-1248, MPV1248, MPV 1248, Antisedan","CCC1(CC2=C(C1)C=CC=C2)C3=CN=C[NH]3",3.012,1,1,2]
["S4651","Etoricoxib","b9","L3900-18","in 10mM DMSO","COX","Neuronal Signaling","Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.",358.84,"202409-33-4",{"v":71,"d":"71.00"},197.86,"<1","N/A","http://selleckchem.com/products/etoricoxib.html","C18H15ClN2O2S","free base","Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia","CC1=NC=C(C=C1)C2=NC=C(Cl)C=C2C3=CC=C(C=C3)[S](C)(=O)=O",3.467,4,0,3]
["S4655","Sulpiride","c9","L3900-18","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.",341.43,"15676-16-1",{"v":68,"d":"68.00"},199.16,"<1","N/A","http://selleckchem.com/products/sulpiride.html","C15H23N3O4S","free base","Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil","CCN1CCCC1CNC(=O)C2=C(OC)C=CC(=C2)[S](N)(=O)=O",0.704,4,2,6]
["S4656","Parecoxib","d9","L3900-18","in 10mM DMSO","COX","Neuronal Signaling","Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.",370.42,"198470-84-7",{"v":74,"d":"74.00"},199.77,"<1","N/A","http://selleckchem.com/products/parecoxib.html","C19H18N2O4S","free base","SC-69124, Valus-P, Vorth-P","CCC(=O)N[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",3.256,5,1,5]
["S4657","Eslicarbazepine Acetate","e9","L3900-18","in 10mM DMSO","BACE,Sodium Channel","Neuronal Signaling","Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.",296.32,"236395-14-5",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/eslicarbazepine-acetate.html","C17H16N2O3","free base","BIA 2093, Zebinix, Exalief, Stedesa, Aptiom","CC(=O)OC1CC2=C(C=CC=C2)N(C(N)=O)C3=C1C=CC=C3",{"v":2.4,"d":"2.400"},3,1,2]
["S4658","Hydroquinidine","f9","L3900-18","in 10mM DMSO","Others","Others","Hydroquinidine (Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine) is an antiarrhythmic agent.",326.43,"1435-55-8",{"v":65,"d":"65.00"},199.12,"<1","N/A","http://selleckchem.com/products/hydroquinidine.html","C20H26N2O2","free base","Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4660","Glycopyrrolate","g9","L3900-18","in 10mM DMSO","AChR","Neuronal Signaling","Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.",398.33,"596-51-0",{"v":65,"d":"65.00"},163.18,{"v":79,"d":"79.00"},198.33,"http://selleckchem.com/products/glycopyrrolate.html","C19H28NO3.Br","bromide","Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn","[Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)C3=CC=CC=C3",-0.961,2,0,5]
["S4661","Tiagabine hydrochloride","h9","L3900-18","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.",412.01,"145821-59-6",{"v":82,"d":"82.00"},199.02,{"v":11,"d":"11.00"},{"v":26.7,"d":"26.70"},"http://selleckchem.com/products/tiagabine-hydrochloride.html","C20H25NO2S2.HCl","hydrochloride","Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride","Cl.CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(O)=O)C3=C(C)C=CS3",2.634,1,0,6]
["S4662","Atazanavir","a10","L3900-18","in 10mM DMSO","HIV Protease,P450 (e.g. CYP17),P-gp","Proteases","Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.",704.86,"198904-31-3",{"v":71,"d":"71.00"},100.73,"<1","N/A","http://selleckchem.com/products/atazanavir-reyataz.html","C38H52N6O7","free base","Latazanavir, Zrivada, Reyataz, BMS-232632","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C",{"v":4.69,"d":"4.690"},7,5,18]
["S4663","Fusidate Sodium","b10","L3900-18","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Fusidate Sodium (Fucidin, SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.",538.69,"751-94-0",{"v":100,"d":"100.00"},185.64,{"v":100,"d":"100.00"},185.64,"http://selleckchem.com/products/fusidate-sodium.html","C31H47O6.Na","sodium salt","Fucidin, Sodium fusidate, SQ-16360","[Na+].CC1C(O)CCC2(C)C1CCC3(C)C2C(O)CC4\\C(C(CC34C)OC(C)=O)=C(/CCC=C(C)C)C([O-])=O",3.623,2,2,6]
["S4664","Molsidomine","c10","L3900-18","in 10mM DMSO","Others","Others","Molsidomine (SIN-10, Corvaton, Morsydomine) is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.",242.23,"25717-80-0",{"v":48,"d":"48.00"},198.16,{"v":9,"d":"9.00"},37.15,"http://selleckchem.com/products/molsidomine.html","C9H14N4O4","inner salt","SIN-10, Corvaton, Morsydomine","CCOC(=O)[N-]C1=C[N+](=NO1)N2CCOCC2",{"v":0.42,"d":"0.420"},5,0,4]
["S4666","Sivelestat sodium tetrahydrate","d10","L3900-18","in 10mM DMSO","Serine Protease","Proteases","Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.",528.51,"201677-61-4",{"v":100,"d":"100.00"},189.21,"<1","N/A","http://selleckchem.com/products/sivelestat-sodium.html","C20H21N2O7S.4H2O.Na","sodium salt","Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium","O.O.O.O.[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC([O-])=O",0.018,5,2,9]
["S4667","Lidocaine hydrochloride","e10","L3900-18","in 10mM DMSO","EGFR","Angiogenesis","Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.",{"v":270.8,"d":"270.80"},"73-78-9",{"v":54,"d":"54.00"},199.41,{"v":54,"d":"54.00"},199.41,"http://selleckchem.com/products/lidocaine-hydrochloride.html","C14H22N2O.HCl","hydrochloride","Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural","Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",3.008,1,1,5]
["S4669","Benzocaine hydrochloride","f10","L3900-18","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Benzocaine hydrochloride (Ethyl 4-aminobenzoate, Ethyl p-aminobenzoate) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.",201.65,"23239-88-5",{"v":40,"d":"40.00"},198.36,"<1","N/A","http://selleckchem.com/products/benzocaine-hydrochloride.html","C9H11NO2.HCl","hydrochloride","Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride","Cl.CCOC(=O)C1=CC=C(N)C=C1",1.669,2,1,3]
["S4673","Etonogestrel","g10","L3900-18","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Etonogestrel (Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel) is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.",324.46,"54048-10-1",{"v":64,"d":"64.00"},197.25,"<1","N/A","http://selleckchem.com/products/etonogestrel.html","C22H28O2","free base","Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel","CCC12CC(=C)C3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.827,1,0,1]
["S4674","Hydroxyprogesterone caproate","h10","L3900-18","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Hydroxyprogesterone Caproate (17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.",{"v":428.6,"d":"428.60"},"630-56-8",{"v":85,"d":"85.00"},198.32,"<1","N/A","http://selleckchem.com/products/hydroxyprogesterone-caproate.html","C27H40O4","free base","17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate","CCCCCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C)C(C)=O",5.539,4,0,7]
["S4678","Povidone iodine","a11","L3900-18","in 10mM DMSO","Anti-infection,Hydrotropic Agents","Microbiology","Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.","N/A","25655-41-8",{"v":28,"d":"28.00"},{"v":10,"d":"10.00"},{"v":28,"d":"28.00"},"N/A","http://selleckchem.com/products/povidone-iodine.html","(C6H9NO)x.xI2","free base","Betadine, PVP iodine, PVP-I, Isodine","CCC(C)N1CCCC1=O",{"v":0,"d":"0.000"},0,0,0]
["S4679","Terazosin HCl","b11","L3900-18","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.",423.89,"63074-08-8",{"v":84,"d":"84.00"},198.16,{"v":1,"d":"1.00"},2.36,"http://selleckchem.com/products/terazosin.html","C19H25N5O4.HCl","hydrochloride","Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin","Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N",1.762,6,1,4]
["S4682","Loxoprofen","c11","L3900-18","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.",{"v":246.3,"d":"246.30"},"68767-14-6",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/loxoprofen.html","C15H18O3","free base","Koloxo, Loxoprofene, Loxoprofeno","CC(C(O)=O)C1=CC=C(CC2CCCC2=O)C=C1",2.936,2,0,4]
["S4683","Sildenafil Mesylate","d11","L3900-18","in 10mM DMSO","PDE","Metabolism","Sildenafil Mesylate(UK-92480 Mesylate) is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.","474.58(free base)","1308285-21-3",{"v":100,"d":"100.00"},{"v":211,"d":"211.00"},{"v":100,"d":"100.00"},"N/A","http://selleckchem.com/products/sildenafil-mesylate.html","C22H30N6O4S.xCH4O3S","Mesylate","UK-92480 Mesylate","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.C[S](O)(=O)=O",1.833,6,1,7]
["S4685","Efavirenz","e11","L3900-18","in 10mM DMSO","Reverse Transcriptase","Microbiology","Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.",315.67,"154598-52-4",{"v":63,"d":"63.00"},199.58,"<1","N/A","http://selleckchem.com/products/efavirenz.html","C14H9ClF3NO2","free base","Sustiva, Stocrin, DMP-266, DMP 266","FC(F)(F)C1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC3CC3",4.381,2,1,3]
["S4686","Vitamin E","f11","L3900-18","in 10mM DMSO","COX,VEGFR","Neuronal Signaling","Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.",430.71,"59-02-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e.html","C29H50O2","free base","Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S4687","Rivastigmine","g11","L3900-18","in 10mM DMSO","AChR","Neuronal Signaling","Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).",250.34,"123441-03-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/rivastigmine.html","C14H22N2O2","free base","SDZ-ENA 713, Exelon","CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C",2.599,2,0,5]
["S4689","Deoxycholic acid","h11","L3900-18","in 10mM DMSO","GPCR19","GPCR & G Protein","Deoxycholic acid (Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic) is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity.  Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.",392.57,"83-44-3",{"v":78,"d":"78.00"},198.69,"<1","N/A","http://selleckchem.com/products/deoxycholic-acid.html","C24H40O4","free base","Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic","CC(CCC(O)=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C",4.082,1,2,4]
["S4690","Escin","a2","L3900-19","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Escin (Aescin) is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).",1131.26,"6805-41-0",{"v":66,"d":"66.00"},58.34,"<1","N/A","http://selleckchem.com/products/escin.html","C55H86O24","free base","Aescin","C\\C=C(C)/C(=O)OC1C(OC(C)=O)C2(CO)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(OC7OC(CO)C(O)C(O)C7O)C(O)C6OC8OC(CO)C(O)C(O)C8O)C(O)=O)C(C)(CO)C5CCC34C)C2CC1(C)C",-0.723,11,12,16]
["S4693","Guanfacine Hydrochloride","b2","L3900-19","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.",282.55,"29110-48-3",{"v":56,"d":"56.00"},{"v":198.2,"d":"198.20"},{"v":30,"d":"30.00"},106.18,"http://selleckchem.com/products/guanfacine-hydrochloride.html","C9H9Cl2N3O.HCl","hydrochloride","Guanfacine, Tenex, Intuniv","Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl",2.412,1,2,3]
["S4695","D panthenol","c2","L3900-19","in 10mM DMSO","Vitamin","Metabolism","D panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent.",205.25,"81-13-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/d-panthenol.html","C9H19NO4","free base","Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol","CC(C)(CO)C(O)C(=O)NCCCO",-1.266,1,4,6]
["S4696","CarbinoxaMine Maleate","d2","L3900-19","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Carbinoxamine maleate is a histamine-H1 receptor blocking agent with antihistamine and anticholinergic properties.",406.86,"3505-38-2",{"v":81,"d":"81.00"},199.09,{"v":81,"d":"81.00"},199.09,"http://selleckchem.com/products/carbinoxamine-maleate.html","C16H19ClN2O.C4H4O4","maleate","N/A","CN(C)CCOC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.OC(=O)\\C=C/C(O)=O",0.224,4,0,8]
["S4697","Saxagliptin hydrate","e2","L3900-19","in 10mM DMSO","DPP","Proteases","Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",333.43,"945667-22-1",{"v":66,"d":"66.00"},197.94,{"v":1,"d":"1.00"},{"v":3,"d":"3.00"},"http://selleckchem.com/products/saxagliptin-hydrate.html","C18H25N3O2.H2O","hydrate","BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate","O.NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.068,1,1,2]
["S4698","Vitamin K1","f2","L3900-19","in 10mM DMSO","Vitamin","Metabolism","Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. Vitamin K1 is directly involved in photosynthesis.",{"v":450.7,"d":"450.70"},"84-80-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/vitamin-k1.html","C31H46O2","2-methyl-1,4-naphthoquinones","Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione","CC(C)CCCC(C)CCCC(C)CCC/C(C)=C/CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O",{"v":10.25,"d":"10.250"},2,0,14]
["S4701","2-Deoxy-D-glucose (2-DG)","g2","L3900-19","in 10mM DMSO","Apoptosis related,Carbohydrate Metabolism,HSV","Metabolism","2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.",164.16,"154-17-6",{"v":32,"d":"32.00"},194.93,{"v":32,"d":"32.00"},194.93,"http://selleckchem.com/products/2-deoxy-d-glucose.html","C6H12O5","free base","2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose","OCC1OC(O)CC(O)C1O",-1.748,1,3,1]
["S4706","Eugenol","h2","L3900-19","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.",{"v":164.2,"d":"164.20"},"97-53-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/eugenol.html","C10H12O2","Free Base","4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol","COC1=C(O)C=CC(=C1)CC=C",2.579,1,1,3]
["S4708","Palmitoylethanolamide","a3","L3900-19","in 10mM DMSO","PPAR","Metabolism","Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.",299.49,"544-31-0",{"v":59,"d":"59.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/palmitoylethanolamide.html","C18H37NO2","free base","Palmidrol|N-palmitoylethanolamine","CCCCCCCCCCCCCCCC(=O)NCCO",5.431,1,2,16]
["S4709","Latanoprost","b3","L3900-19","in 10mM DMSO","GPR,Immunology & Inflammation related,RAR/RXR","Immunology & Inflammation","Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.",432.59,"130209-82-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/latanoprost.html","C26H40O5","Free Base","Xalatan, PhXA41, PHXA-41","CC(C)OC(=O)CCC\\C=C/CC1C(O)CC(O)C1CCC(O)CCC2=CC=CC=C2",4.365,2,3,14]
["S4711","Esculetin","c3","L3900-19","in 10mM DMSO","Lipoxygenase","Metabolism","Esculetin (Cichorigenin, Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).",178.14,"305-01-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/esculetin.html","C9H6O4","free base","Cichorigenin, Aesculetin","OC1=CC2=C(C=CC(=O)O2)C=C1O",1.415,2,2,0]
["S4714","(-)-Menthol","d3","L3900-19","in 10mM DMSO","TRP Channel","Transmembrane Transporters","(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.",156.27,"2216-51-5",{"v":31,"d":"31.00"},198.37,{"v":16,"d":"16.00"},102.39,"http://selleckchem.com/products/-menthol.html","C10H20O","free base","L-Menthol, Levomenthol, Menthomenthol, Menthacamphor","CC(C)C1CCC(C)CC1O",2.779,0,1,1]
["S4715","Benzamide","e3","L3900-19","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Benzamide, a derivative of benzoic acid, is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.",121.14,"55-21-0",{"v":24,"d":"24.00"},198.12,"<1","N/A","http://selleckchem.com/products/benzamide.html","C7H7NO","free base","N/A","NC(=O)C1=CC=CC=C1",0.832,1,1,1]
["S4719","Kynurenic acid","f3","L3900-19","in 10mM DMSO","NMDAR","Neuronal Signaling","Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA\n\nreceptors.",189.17,"492-27-3",{"v":10,"d":"10.00"},52.86,"<1","N/A","http://selleckchem.com/products/kynurenic-acid.html","C10H7NO3","free base","Quinurenic acid, Kynurenate","OC(=O)C1=CC(=C2C=CC=CC2=N1)O",1.832,2,1,1]
["S4723","(-)Epicatechin","g3","L3900-19","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(−)Epicatechin (L-Epicatechin, (-)-Epicatechol) is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.",290.27,"490-46-0",{"v":58,"d":"58.00"},199.81,"<1","N/A","http://selleckchem.com/products/-epicatechin.html","C15H14O6","free base","L-Epicatechin, (-)-Epicatechol","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4725","Benzenesulfonamide","h3","L3900-19","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.",157.19,"98-10-2",{"v":31,"d":"31.00"},197.21,"<1","N/A","http://selleckchem.com/products/benzenesulfonamide.html","C6H7NO2S","free base","Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide","N[S](=O)(=O)C1=CC=CC=C1",0.535,2,1,1]
["S4727","Cinnarizine","a4","L3900-19","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.",368.51,"298-57-7",{"v":73,"d":"73.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/cinnarizine.html","C26H28N2","free base","Stugeron, Dimitronal, Stutgin, Cinarizine","C1CN(CCN1C\\C=C\\C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4",5.524,0,0,6]
["S4728","3,3'-Diindolylmethane","b4","L3900-19","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","3,3'-Diindolylmethane(DIM) is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.",246.31,"1968-05-4",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/3-3-diindolylmethane.html","C17H14N2","free base","DIM","C(C1=C[NH]C2=C1C=CC=C2)C3=C[NH]C4=C3C=CC=C4",4.391,0,2,2]
["S4731","Perphenazine","c4","L3900-19","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.",403.97,"58-39-9",{"v":74,"d":"74.00"},183.18,"<1","N/A","http://selleckchem.com/products/perphenazine.html","C21H26ClN3OS","free base","Perphenazin, Trilafon, Etaperazine","OCCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4)CC1",4.157,0,1,6]
["S4733","Retigabine","d4","L3900-19","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Retigabine (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.",303.33,"150812-12-7",{"v":60,"d":"60.00"},{"v":197.8,"d":"197.80"},"<1","N/A","http://selleckchem.com/products/retigabine.html","C16H18FN3O2","free base","D-23129, N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid","CCOC(=O)NC1=CC=C(NCC2=CC=C(F)C=C2)C=C1N",2.793,2,3,6]
["S4734","Retigabine 2HCl","e4","L3900-19","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Retigabine 2HCl (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.",376.25,"150812-13-8",{"v":75,"d":"75.00"},199.34,{"v":75,"d":"75.00"},199.34,"http://selleckchem.com/products/retigabine-2hcl.html","C16H18FN3O2.2HCl","dihydrochloride","N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid (2HCl), D-23129 2HCl","Cl.Cl.CCOC(=O)NC1=CC=C(NCC2=CC=C(F)C=C2)C=C1N",3.557,2,3,6]
["S4737","Psoralen","f4","L3900-19","in 10mM DMSO","ADC Cytotoxin,DNA/RNA Synthesis","DNA Damage/DNA Repair","Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.",186.16,"66-97-7",{"v":37,"d":"37.00"},198.75,"<1","N/A","http://selleckchem.com/products/psoralen.html","C11H6O3","free base","Psoralene, Ficusin, Furocoumarin","O=C1OC2=C(C=C1)C=C3C=COC3=C2",2.203,3,0,0]
["S4743","Wogonin","g4","L3900-19","in 10mM DMSO","CDK,Transferase","Cell Cycle","Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.",284.26,"632-85-9",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/wogonin.html","C16H12O5","free base","Vogonin","COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C3=CC=CC=C3",2.636,3,2,2]
["S4749","Citalopram HBr","h4","L3900-19","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.",{"v":405.3,"d":"405.30"},"59729-32-7",{"v":81,"d":"81.00"},199.85,{"v":81,"d":"81.00"},199.85,"http://selleckchem.com/products/citalopram-hbr.html","C20H21FN2O.HBr","hydrobromide","Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr","Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C3=CC=C(F)C=C3",4.212,1,0,5]
["S4750","Sulfacetamide sodium salt hydrate","a5","L3900-19","in 10mM DMSO","Antibiotics,Autophagy,Bacterial","Autophagy","Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.",254.24,"6209-17-2",{"v":50,"d":"50.00"},196.66,{"v":50,"d":"50.00"},196.66,"http://selleckchem.com/products/sulfacetamide-sodium-salt-hydrate.html","C8H9N2O3S.H2O.Na","sodium salt hyd","N/A","O.CC(=O)N([Na])[S](=O)(=O)C1=CC=C(N)C=C1",-0.326,3,1,2]
["S4751","Cisapride hydrate","b5","L3900-19","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.",483.96,"260779-88-2",{"v":96,"d":"96.00"},198.36,"<1","N/A","https://www.selleckchem.com/products/cisapride-hydrate.html","C23H29ClFN3O4.H2O","hydrate","Propulsid, Alimix, Propulsin, Enteropride, Kinestase","O.COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C3=CC(=C(N)C=C3OC)Cl",2.578,4,2,9]
["S4752","Corticosterone (NSC-9705)","c5","L3900-19","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Corticosterone (NSC-9705, 17-deoxycortisol, 11β,21-dihydroxyprogesterone), the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.",346.46,"50-22-6",{"v":69,"d":"69.00"},199.16,"<1","N/A","http://selleckchem.com/products/corticosterone.html","C21H30O4","free base","17-deoxycortisol, 11β,21-dihydroxyprogesterone","CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO",2.019,2,2,2]
["S4760","(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)","d5","L3900-19","in 10mM DMSO","Beta Amyloid,Hydrotropic Agents","Neuronal Signaling","(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin), a well-known sugar used in drug delivery, genetic vector, environmental protection and treatment of Niemann-Pick disease type C1 (NPC1), is an inhibitor of amyloid-β aggregation.",1541.54,"128446-35-5",{"v":100,"d":"100.00"},64.87,{"v":100,"d":"100.00"},64.87,"http://selleckchem.com/products/2-hydroxypropyl-beta-cyclodextrin-hp-beta-cd.html","C63H112O42","free base","HP-β-cyclodextrin, Hydroxypropyl betadex, Hydroxypropyl-β-cyclodextrin","CC(O)COCC1OC2OC3C(O)C(O)C(OC3COCC(C)O)OC4C(O)C(O)C(OC4COCC(C)O)OC5C(O)C(O)C(OC5COCC(C)O)OC6C(O)C(O)C(OC6COCC(C)O)OC7C(O)C(O)C(OC7COCC(C)O)OC8C(O)C(O)C(OC8COCC(C)O)OC1C(O)C2O",-10.503,21,21,28]
["S4761","Thymoquinone","e5","L3900-19","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects.",{"v":164.2,"d":"164.20"},"490-91-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/thymoquinone.html","C10H12O2","free base","N/A","CC(C)C1=CC(=O)C(=CC1=O)C",2.288,2,0,1]
["S4769","L-5-Hydroxytryptophan","f5","L3900-19","in 10mM DMSO","Others","Others","5-Hydroxytryptophan (5-HTP, L-oxitriptan), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.",220.22,"4350-09-8",{"v":16,"d":"16.00"},72.65,"N/A","N/A","http://selleckchem.com/products/l-5-hydroxytryptophan.html","C11H12N2O3","free base","L-oxitriptan","NC(CC1=C[NH]C2=CC=C(O)C=C12)C(O)=O",-1.554,1,3,3]
["S4777","Plumbagin","g5","L3900-19","in 10mM DMSO","Apoptosis related","Apoptosis","Plumbagin (Plumbagine, Plumbaein, Plumbagone), a quinoid constituent isolated from the root of the medicinal plant Plumbago zeylanica L, exerts anticancer and antiproliferative activities in animal models and in cell culture.",188.18,"481-42-5",{"v":37,"d":"37.00"},196.62,"N/A","N/A","http://selleckchem.com/products/plumbagin.html","C11H8O3","free base","Plumbagine, Plumbaein, Plumbagone","CC1=CC(=O)C2=C(C=CC=C2O)C1=O",1.962,2,1,0]
["S4792","N-Acetylneuraminic acid","h5","L3900-19","in 10mM DMSO","Others","Others","N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.",309.27,"131-48-6",{"v":61,"d":"61.00"},{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/n-acetylneuraminic-acid.html","C11H19NO9","free base","Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid","CC(=O)NC1C(O)CC(O)(OC1C(O)C(O)CO)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4797","Nicergoline","a6","L3900-19","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions.",484.39,"27848-84-6",{"v":22,"d":"22.00"},45.42,"N/A","N/A","http://selleckchem.com/products/nicergoline.html","C24H26BrN3O3","free base","N/A","COC12CC(COC(=O)C3=CN=CC(=C3)Br)CN(C)C1CC4=C[N](C)C5=CC=CC2=C45",{"v":0,"d":"0.000"},0,0,0]
["S4803","Thymidine (NSC 21548)","b6","L3900-19","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Thymidine (Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd, NSC 21548) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.",242.23,"50-89-5",{"v":48,"d":"48.00"},198.16,"N/A","N/A","http://selleckchem.com/products/thymidine.html","C10H14N2O5","free base","Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd","CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O",{"v":0,"d":"0.000"},0,0,0]
["S4812","Ceftizoxime","c6","L3900-19","in 10mM DMSO","Antibiotics","Microbiology","Ceftizoxime is a semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.",{"v":383.4,"d":"383.40"},"68401-81-0",{"v":76,"d":"76.00"},198.23,"<1","N/A","http://selleckchem.com/products/ceftizoxime.html","C13H13N5O5S2","free base","N/A","CO\\N=C(C(=O)NC1C2SCC=C(N2C1=O)C(O)=O)\\C3=CSC(=N3)N",-0.644,6,2,5]
["S4813","Cefuroxime axetil","d6","L3900-19","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, is a second generation oral cephalosporin antibiotic with in vitro antibacterial activity against several gram-positive and gram-negative organisms.",510.47,"64544-07-6",{"v":100,"d":"100.00"},{"v":195.9,"d":"195.90"},"N/A","N/A","http://selleckchem.com/products/cefuroxime-axetil.html","C20H22N4O10S","free base","N/A","CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OC(C)OC(C)=O)COC(N)=O)C3=CC=CO3",-0.178,11,2,12]
["S4815","L-Cysteine HCl","e6","L3900-19","in 10mM DMSO","Others","Others","L-cysteine Hydrochloride, also known as L-CYSTEINE or Cysteine HCL (anhydrous), is classified as a cysteine or a cysteine derivative that increases glutathione levels and is important for lung and brain function and liver detoxification.",157.62,"52-89-1",{"v":31,"d":"31.00"},196.68,"N/A","N/A","http://selleckchem.com/products/l-cysteine-hcl.html","C3H7NO2S.ClH","hydrochloride","N/A","Cl.NC(CS)C(O)=O",-2.696,1,1,2]
["S4816","Diatrizoate sodium","f6","L3900-19","in 10mM DMSO","Others","Others","Diatrizoate sodium (Amidotrizoate sodium, Hypaque sodium, Triombrin) is an iodinated radiopaque X-ray contrast medium that is used as a diagnostic aid in angiography, urography and radiography.",{"v":635.9,"d":"635.90"},"737-31-5",{"v":100,"d":"100.00"},157.26,"N/A","N/A","http://selleckchem.com/products/diatrizoate-sodium.html","C11H8I3N2O4.Na","sodium","amidotrizoate sodium, Hypaque sodium, Triombrin","[Na+].CC(=O)NC1=C(I)C(=C(I)C(=C1I)NC(C)=O)C([O-])=O",-0.039,2,2,3]
["S4817","Atenolol","g6","L3900-19","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.",266.34,"29122-68-7",{"v":53,"d":"53.00"},198.99,{"v":35,"d":"35.00"},131.41,"http://selleckchem.com/products/atenolol.html","C14H22N2O3","free base","Tenormin, Normiten, Blokium","CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1",0.669,2,3,8]
["S4819","Saccharin","h6","L3900-19","in 10mM DMSO","Others","Others","Saccharin (Benzoic sulfimide, O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide) is an artificial sweetener with effectively no food energy.",183.18,"81-07-2",{"v":36,"d":"36.00"},196.53,"N/A","N/A","http://selleckchem.com/products/saccharin.html","C7H5NO3S","free base","Benzoic sulfimide, O-Sulfobenzimide, O-Benzoic sulfimide, Saccharimide","O=C1N[S](=O)(=O)C2=C1C=CC=C2",0.359,3,1,0]
["S4830","Maltose","a7","L3900-19","in 10mM DMSO","Others","Others","Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose), an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables).",{"v":342.3,"d":"342.30"},"69-79-4",{"v":68,"d":"68.00"},198.66,"N/A","N/A","http://selleckchem.com/products/maltose.html","C12H22O11","free base","Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose","OCC(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)C(O)C=O",-4.538,3,8,8]
["S4831","Piperonyl butoxide","b7","L3900-19","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Piperonyl butoxide (PBO, Butacide, Ethanol butoxide, Pyrenone 606,ENT-14250) is a man-made pesticide synergist, working with insect killers to increase their effectiveness.Piperonyl butoxide is an inhibitor of cytochrome P450 monooxygenases(P450s).",338.44,"51-03-6",{"v":67,"d":"67.00"},197.97,"N/A","N/A","http://selleckchem.com/products/piperonyl-butoxide.html","C19H30O5","Peroxides","Butacide, Ethanol butoxide, Pyrenone 606,ENT-14250","CCCCOCCOCCOCC1=CC2=C(OCO2)C=C1CCC",3.867,5,0,13]
["S4833","Cefoxitin sodium","c7","L3900-19","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefoxitin Sodium is the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.",449.43,"33564-30-6",{"v":89,"d":"89.00"},198.03,{"v":89,"d":"89.00"},198.03,"http://selleckchem.com/products/cefoxitin-sodium.html","C16H16N3O7S2.Na","sodium salt","N/A","[Na+].COC1(NC(=O)CC2=CC=CS2)C3SCC(=C(N3C1=O)C([O-])=O)COC(N)=O",-1.151,5,2,8]
["S4834","Propantheline bromide","d7","L3900-19","in 10mM DMSO","AChR","Neuronal Signaling","Propantheline bromide (Pro-Banthine, Neometantyl, Neopepulsan) is a muscarinic antagonist used to treat gastrointestinal conditions associated with intestinal spasm and to decrease secretions during anesthesia.",448.39,"50-34-0",{"v":89,"d":"89.00"},198.49,"N/A","N/A","http://selleckchem.com/products/propantheline-bromide.html","C23H30NO3.Br","bromide","Pro-Banthine, Neometantyl, Neopepulsan","[Br-].CC(C)[N+](C)(CCOC(=O)C1C2=C(OC3=CC=CC=C13)C=CC=C2)C(C)C",0.763,3,0,7]
["S4835","Aceclofenac","e7","L3900-19","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.",354.18,"89796-99-6",{"v":70,"d":"70.00"},197.64,"N/A","N/A","http://selleckchem.com/products/aceclofenac.html","C16H13Cl2NO4","free base","Preservex, Airtal","OC(=O)COC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",{"v":4.08,"d":"4.080"},3,1,7]
["S4836","Nilutamide","f7","L3900-19","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Nilutamide (RU23908) is a nonsteroidal antiandrogen (NSAA) with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). It is used in the treatment of prostate cancer.",317.22,"63612-50-0",{"v":63,"d":"63.00"},{"v":198.6,"d":"198.60"},"<1","N/A","http://selleckchem.com/products/nilutamide.html","C12H10F3N3O4","Nonsteroidal antiandrogens","RU23908","CC1(C)NC(=O)N(C2=CC=C(C(=C2)C(F)(F)F)[N+]([O-])=O)C1=O",2.254,2,1,3]
["S4837","Ibudilast","g7","L3900-19","in 10mM DMSO","PDE","Metabolism","Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.",230.31,"50847-11-5",{"v":46,"d":"46.00"},199.73,{"v":30,"d":"30.00"},130.26,"http://selleckchem.com/products/Ibudilast.html","C14H18N2O","free base","KC-404, AV411, MN166","CC(C)C(=O)C1=C2C=CC=C[N]2N=C1C(C)C",3.339,2,0,3]
["S4838","Acotiamide hydrochloride","h7","L3900-19","in 10mM DMSO","AChR","Neuronal Signaling","Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.",541.06,"773092-05-0",{"v":100,"d":"100.00"},184.82,{"v":5,"d":"5.00"},9.24,"http://selleckchem.com/products/acotiamide-hydrochloride.html","C21H30N4O5S.HCl.3H2O","hydrochloride trihydrate","YM-443 HCl, Z-338 HCl","O.O.O.Cl.COC1=CC(=C(C=C1OC)C(=O)NC2=NC(=CS2)C(=O)NCCN(C(C)C)C(C)C)O",2.325,5,3,10]
["S4839","Mosapride","a8","L3900-19","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.",421.89,"112885-41-3",{"v":84,"d":"84.00"},{"v":199.1,"d":"199.10"},"N/A","N/A","http://selleckchem.com/products/mosapride.html","C21H25ClFN3O3","Benzamide","N/A","CCOC1=CC(=C(Cl)C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(F)C=C3)N",2.932,3,2,7]
["S4844","Cefcapene Pivoxil Hydrochloride","b8","L3900-19","in 10mM DMSO","Bacterial","Microbiology","Cefcapene Pivoxil is the pivalate ester prodrug form of cefcapene, a semi-synthetic third-generation cephalosporin with antibacterial activity.",622.11,"147816-24-8",{"v":100,"d":"100.00"},160.74,"N/A","N/A","http://selleckchem.com/products/cefcapene-pivoxil-hydrochloride.html","C23H29N5O8S2.HCl.H2O","hydrochloride, hydrate","N/A","O.Cl.CC\\C=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)COC(N)=O)C3=CSC(=N3)N",2.027,9,3,13]
["S4845","Rabeprazole","c8","L3900-19","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Rabeprazole(LY307640) is an oral inhibitor of proton pump and blocks the production of acid by the stomach.",359.44,"117976-89-3",{"v":71,"d":"71.00"},197.53,{"v":71,"d":"71.00"},197.53,"http://selleckchem.com/products/rabeprazole.html","C18H21N3O3S","free base","LY307640","COCCCOC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=C([NH]2)C=CC=C3",2.366,5,1,8]
["S4846","Meropenem Trihydrate","d8","L3900-19","in 10mM DMSO","Bacterial","Microbiology","Meropenem is a broad-spectrum antibacterial agent of the carbapenem family with a broad spectrum of in vitro activity against Gram-positive and Gram-negative pathogens.",437.51,"119478-56-7",{"v":87,"d":"87.00"},198.85,{"v":87,"d":"87.00"},198.85,"http://selleckchem.com/products/meropenem-trihydrate.html","C17H25N3O5S.3H2O","trihydrate","N/A","O.O.O.CC(O)C1C2C(C)C(=C(N2C1=O)C(O)=O)SC3CNC(C3)C(=O)N(C)C",{"v":-4.75,"d":"-4.750"},3,2,5]
["S4847","Faropenem Sodium","e8","L3900-19","in 10mM DMSO","Antibiotics","Microbiology","Faropenem sodium is an orally active beta-lactam antibiotic that has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia.",{"v":307.3,"d":"307.30"},"122547-49-3",{"v":12,"d":"12.00"},39.05,{"v":61,"d":"61.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/faropenem-sodium.html","C12H14NO5S.Na","sodium","N/A","[Na+].CC(O)C1C2SC(=C(N2C1=O)C([O-])=O)C3CCCO3",-1.793,2,1,3]
["S4848","Dalbavancin","f8","L3900-19","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.",1816.69,"171500-79-1",{"v":100,"d":"100.00"},55.05,{"v":100,"d":"100.00"},55.05,"http://selleckchem.com/products/dalbavancin.html","C88H100Cl2N10O28","free base","Zeven, BI 397, MDL 63397","CNC1C(=O)NC2CC3=CC=C(OC4=C(OC5OC(C(O)C(O)C5NC(=O)CCCCCCCCC(C)C)C(O)=O)C6=CC(=C4)C(NC(=O)C(NC2=O)C7=CC(=CC(=C7Cl)O)OC8=CC=C1C=C8O)C(=O)NC9C(=O)NC(C(O)C%10=CC(=C(O6)C=C%10)Cl)C(=O)NC(C(=O)NCCCN(C)C)C%11=C(C(=CC(=C%11)O)OC%12OC(CO)C(O)C(O)C%12O)C%13=CC9=CC=C%13O)C=C3",1.865,16,20,22]
["S4849","Levocetirizine Dihydrochloride","g8","L3900-19","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.",461.81,"130018-87-0",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/levocetirizine-dihydrochloride.html","C21H25ClN2O3.2HCl","dihydrochloride","Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S4850","Flucloxacillin sodium","h8","L3900-19","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Flucloxacillin sodium (Floxacillin sodium) is the sodium salt of flucloxacillin, a penicillin antibiotic used to treat bacterial infections.",475.85,"1847-24-1",{"v":95,"d":"95.00"},199.64,{"v":95,"d":"95.00"},199.64,"http://selleckchem.com/products/flucloxacillin-sodium.html","C19H16ClFN3O5S.Na","sodium salt","Floxacillin sodium","[Na+].CC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C([O-])=O)C(=NO1)C4=C(F)C=CC=C4Cl",1.031,4,1,4]
["S4851","Tafluprost","a9","L3900-19","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.",452.53,"209860-87-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/tafluprost.html","C25H34F2O5","Prostaglandin analogue","AFP-168,MK2452","CC(C)OC(=O)CCC\\C=C/CC1C(O)CC(O)C1/C=C/C(F)(F)COC2=CC=CC=C2",4.329,3,2,13]
["S4852","Gadopentetate Dimeglumine","b9","L3900-19","in 10mM DMSO","Others","Others","Gadopentetate Dimeglumine (Gadopentetic acid dimeglumine, Gd-DTPA, Meglumine gadopentetate), a complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, is an extracellular intravenous contrast agent used in magnetic resonance imaging.",{"v":938,"d":"938.00"},"86050-77-3",{"v":100,"d":"100.00"},106.61,"N/A","N/A","http://selleckchem.com/products/gadopentetate-dimeglumine.html","C14H18GdN3O10.2C7H17NO5.2H","dimeglumine salt","Gadopentetic acid dimeglumine, Gd-DTPA, Meglumine gadopentetate","CNCC(O)C(O)C(O)C(O)CO.CNCC(O)C(O)C(O)C(O)CO.OC(=O)CN1CCN2CCN(CC(O)=O)CC(=O)O[Gd](OC(=O)C2)OC(=O)C1",-13.058,8,12,16]
["S4853","Ecabet sodium","c9","L3900-19","in 10mM DMSO","ROS","Apoptosis","Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8, Ecabet sodium can also reduce apoptosis.",402.48,"86408-72-2",{"v":80,"d":"80.00"},198.77,{"v":16,"d":"16.00"},39.75,"http://selleckchem.com/products/ecabet-sodium.html","C20H27O5S.Na","sodium salt","TA-2711, TA-2711E","[Na+].CC(C)C1=CC2=C(C=C1[S]([O-])(=O)=O)C3(C)CCCC(C)(C3CC2)C(O)=O",2.477,1,0,3]
["S4854","Bedaquiline fumarate","d9","L3900-19","in 10mM DMSO","Bacterial","Microbiology","Bedaquiline fumarate (TMC-207), an oral diarylquinoline,  is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.",671.58,"845533-86-0",{"v":100,"d":"100.00"},{"v":148.9,"d":"148.90"},"<1","N/A","http://selleckchem.com/products/bedaquiline-fumarate.html","C32H31BrN2O2.C4H4O4","fumarate","TMC-207","COC1=C(C=C2C=C(Br)C=CC2=N1)C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=C5C=CC=CC5=CC=C4.OC(=O)\\C=C\\C(O)=O",3.937,4,0,10]
["S4862","Squalene","e9","L3900-19","in 10mM DMSO","Fungal","Microbiology","Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.",410.72,"111-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/squalene.html","C30H50","free base","Spinacene, Supraene, trans-Squalene","CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(C)\\CC\\C=C(C)\\CCC=C(C)C",11.331,0,0,15]
["S4865","Cefetamet pivoxil hydrochloride","f9","L3900-19","in 10mM DMSO","Antibiotics","Microbiology","Cefetamet pivoxil hydrochloride is the hydrochloride salt form of cefetamet pivoxil, which is an oral third-generation cephalosporin antibiotic.",548.03,"111696-23-2",{"v":100,"d":"100.00"},182.47,"<1","N/A","http://selleckchem.com/products/cefetamet-pivoxil-hydrochloride.html","C20H25N5O7S2.HCl","hydrochloride","N/A","Cl.CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)C)C3=CSC(=N3)N",1.778,9,2,10]
["S4867","Propacetamol hydrochloride","g9","L3900-19","in 10mM DMSO","Others","Others","Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders.",300.78,"66532-86-3",{"v":60,"d":"60.00"},199.48,{"v":60,"d":"60.00"},199.48,"http://selleckchem.com/products/propacetamol-hydrochloride.html","C14H20N2O3.HCl","hydrochloride","N/A","Cl.CCN(CC)CC(=O)OC1=CC=C(NC(C)=O)C=C1",1.803,3,1,7]
["S4869","Sulfamethoxazole sodium","h9","L3900-19","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Sulfamethoxazole sodium is an antibiotic used for bacterial infections.",275.26,"4563-84-2",{"v":55,"d":"55.00"},199.81,"N/A","N/A","http://selleckchem.com/products/sulfamethoxazole-sodium.html","C10H10N3O3S.Na","sodium","N/A","CC1=CC(=NO1)N([Na])[S](=O)(=O)C2=CC=C(N)C=C2",0.813,4,1,3]
["S4871","Pyridoxal 5-phosphate monohydrate","a10","L3900-19","in 10mM DMSO","Vitamin","Metabolism","Pyridoxal 5-phosphate monohydrate is an active vitamin B6 metabolite, which is a cofactor in many reactions of amino acid metabolism.",265.16,"41468-25-1",{"v":22,"d":"22.00"},82.97,"N/A","N/A","http://selleckchem.com/products/pyridoxal-phosphate-monohydrate.html","C8H10NO6P.H2O","hydrate","N/A","O.CC1=NC=C(CO[P](O)(O)=O)C(=C1O)C=O",-0.404,3,1,4]
["S4872","Titanium tetrafluoride","b10","L3900-19","in 10mM DMSO","Others","Others","Titanium tetrafluoride is an inorganic compound that is an effective but instable caries preventive agent.",123.86,"7783-63-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/titanium-tetrafluoride.html","TiF4","salt","N/A","F[Ti](F)(F)F",0.795,0,0,0]
["S4877","Eperisone hydrochloride","c10","L3900-19","in 10mM DMSO","Others","Others","Eperisone hydrochloride is muscle relaxant agent with antispasmodic effects. It is widely used in the treatment of patients with muscular contractures, low back pain or spasticity.",295.85,"56839-43-1",{"v":59,"d":"59.00"},199.43,"N/A","N/A","http://selleckchem.com/products/eperisone-hydrochloride.html","C17H25NO.HCl","hydrochloride","N/A","Cl.CCC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2",4.528,1,0,5]
["S4881","Calcium Dobesilate","d10","L3900-19","in 10mM DMSO","Others","Apoptosis","Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency.",{"v":209.2,"d":"209.20"},"20123-80-2",{"v":41,"d":"41.00"},195.98,"N/A","N/A","http://selleckchem.com/products/calcium-dobesilate.html","C6H5O5S.1/2Ca","Dobesilate","calcium dihydroxy-2,5-benzenesulfonate","OC1=CC=C(O)C(=C1)[S]([O-])(=O)=O",-0.832,0,2,1]
["S4883","Lynestrenol","e10","L3900-19","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Lynestrenol (Ethinylestrenol) is a synthetic progestational hormone, an agonist of the progesterone receptor and has weak androgenic and estrogenic activity.",284.44,"52-76-6",{"v":56,"d":"56.00"},196.88,"N/A","N/A","http://selleckchem.com/products/lynestrenol.html","C20H28O","free base","Ethinylestrenol","CC12CCC3C(CCC4=CCCCC34)C1CCC2(O)C#C",5.316,0,0,0]
["S4885","Taurolidine","f10","L3900-19","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.",284.36,"19388-87-5",{"v":56,"d":"56.00"},196.93,"N/A","N/A","http://selleckchem.com/products/taurolidine.html","C7H16N4O4S2","free base","Taurolin, Tauroline, Tauroflex","O=[S]1(=O)CCN(CN1)CN2CC[S](=O)(=O)NC2",-1.991,4,2,2]
["S4889","Perospirone hydrochloride","g10","L3900-19","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.",463.04,"129273-38-7",{"v":92,"d":"92.00"},198.69,"N/A","N/A","http://selleckchem.com/products/perospirone-hydrochloride.html","C23H30N4O2S.HCl","hydrochloride","SM-9018 hydrochloride","Cl.O=C1C2CCCCC2C(=O)N1CCCCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.423,3,0,6]
["S4893","Cytosine","h10","L3900-19","in 10mM DMSO","Others","Others","Cytosine (4-Amino-2-hydroxypyrimidine, Cytosinimine) is one of the four main bases found in DNA and RNA used in storing and transporting genetic information within a cell.",{"v":111.1,"d":"111.10"},"71-30-7",{"v":10,"d":"10.00"},90.01,"N/A","N/A","http://selleckchem.com/products/cytosine.html","C4H5N3O","free base","4-Amino-2-hydroxypyrimidine, Cytosinimine","NC1=NC(=O)NC=C1",-0.958,2,2,0]
["S4896","Elagolix Sodium","a11","L3900-19","in 10mM DMSO","GNRH Receptor","Endocrinology & Hormones","Elagolix Soidum (NBI-56418, ABT-620) is a potent, selective, orally active, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with Kd value of 54 pM. Concentration at 10 μM shows no significant activity on ion channels, enzymes, and transporters (inhibition <50%).",653.57,"832720-36-2",{"v":100,"d":"100.00"},153.01,{"v":100,"d":"100.00"},153.01,"http://selleckchem.com/products/elagolix-sodium.html","C32H29F5N3O5.Na","sodium","NBI-56418, ABT-620","[Na+].COC1=C(F)C(=CC=C1)C2=C(C)N(CC3=C(F)C=CC=C3C(F)(F)F)C(=O)N(CC(NCCCC([O-])=O)C4=CC=CC=C4)C2=O",4.104,3,1,13]
["S4908","SN-38","b11","L3900-19","in 10mM DMSO","ADC Cytotoxin,Autophagy,Topoisomerase","DNA Damage/DNA Repair","SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.",{"v":392.4,"d":"392.40"},"86639-52-3",{"v":21,"d":"21.00"},53.52,"<1","N/A","http://selleckchem.com/products/sn-38.html","C22H20N2O5","free base","NK012","CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=C1C=C(O)C=C5)C(O)(CC)C(=O)OC4",2.446,4,1,2]
["S4926","(R)-Nepicastat HCl","c11","L3900-19","in 10mM DMSO","Hydroxylase","Metabolism","(R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.",331.81,"195881-94-8",{"v":66,"d":"66.00"},198.91,"<1","N/A","http://selleckchem.com/products/r-nepicastat-hcl.html","C14H15F2N3S.HCl","Hydrochloride","RS-25560-198 HCl","Cl.NCC1=CNC(=S)N1C2CCC3=C(F)C=C(F)C=C3C2",3.008,0,2,2]
["S4927","Cyclen","d11","L3900-19","in 10mM DMSO","Others","Others","Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.",172.27,"294-90-6",{"v":34,"d":"34.00"},197.36,{"v":34,"d":"34.00"},197.36,"http://selleckchem.com/products/cyclen.html","C8H20N4","free base","1,4,7,10-tetraazacyclododecane","C1CNCCNCCNCCN1",-1.589,0,4,0]
["S4931","Propiverine hydrochloride","e11","L3900-19","in 10mM DMSO","AChR,Calcium Channel","Transmembrane Transporters","Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.",403.94,"54556-98-8",{"v":80,"d":"80.00"},198.05,"N/A","N/A","http://selleckchem.com/products/propiverine-hydrochloride.html","C23H29NO3.ClH","HCl","N/A","Cl.CCCOC(C(=O)OC1CCN(C)CC1)(C2=CC=CC=C2)C3=CC=CC=C3",4.388,3,0,8]
["S4935","Asunaprevir (BMS-650032)","f11","L3900-19","in 10mM DMSO","HCV Protease","Proteases","Asunaprevir (BMS-650032) is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.",748.29,"630420-16-5",{"v":100,"d":"100.00"},133.64,"<1","N/A","http://selleckchem.com/products/asunaprevir.html","C35H46ClN5O9S","free base","BMS-650032","COC1=C2C=CC(=CC2=C(OC3CC(N(C3)C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)NC4(CC4C=C)C(=O)N[S](=O)(=O)C5CC5)N=C1)Cl",3.565,10,3,14]
["S4940","Maltol","g11","L3900-19","in 10mM DMSO","Antioxidant","PI3K/Akt/mTOR","Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.",126.11,"118-71-8",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/maltol.html","C6H6O3","Pyrone","Larixinic acid, Palatone, Veltol","CC1=C(O)C(=O)C=CO1",-0.222,2,1,0]
["S4952","Fumaric acid","h11","L3900-19","in 10mM DMSO","Others","Others","Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle.",116.07,"110-17-8",{"v":23,"d":"23.00"},198.16,"N/A","N/A","http://selleckchem.com/products/fumaric-acid.html","C4H4O4","free base","2-Butenedioic acid, Trans-Butenedioic acid, Allomaleic acid, Boletic acid, Donitic acid, Lichenic acid, Fumarate","OC(=O)\\C=C\\C(O)=O",0.038,2,0,2]
["S4958","Glycocholic acid","a2","L3900-20","in 10mM DMSO","Others","Others","Glycocholic acid (Cholylglycine, Glycocholate) is a natural secondary bile acid involved in the emulsification of fats.",465.62,"475-31-0",{"v":93,"d":"93.00"},199.73,"N/A","N/A","http://selleckchem.com/products/glycocholic-acid.html","C26H43NO6","free base","Cholylglycine, Glycocholate","CC(CCC(=O)NCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",1.972,2,4,6]
["S4975","Fimasartan","b2","L3900-20","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.",501.65,"247257-48-3",{"v":100,"d":"100.00"},199.34,"N/A","N/A","http://selleckchem.com/products/fimasartan.html","C27H31N7OS","free base","Kanarb","CCCCC1=NC(=C(CC(=S)N(C)C)C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[NH]4)C",4.515,5,1,10]
["S4977","Efonidipine","c2","L3900-20","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.",631.66,"111011-63-3",{"v":100,"d":"100.00"},158.31,"N/A","N/A","http://selleckchem.com/products/efonidipine.html","C34H38N3O7P","free base","NZ-105","CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",4.956,4,1,11]
["S4980","Anamorelin","d2","L3900-20","in 10mM DMSO","GHSR","GPCR & G Protein","Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN  FLIPR assay.",{"v":546.7,"d":"546.70"},"249921-19-5",{"v":100,"d":"100.00"},182.92,"<1","N/A","http://selleckchem.com/products/anamorelin.html","C31H42N6O3","free base","ONO-7643, RC-1291, ST-1291","CN(C)N(C)C(=O)C1(CCCN(C1)C(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(C)(C)N)CC4=CC=CC=C4",2.447,3,3,9]
["S4994","Methylcobalamin","e2","L3900-20","in 10mM DMSO","Vitamin","Metabolism","Methylcobalamin (Mecobalamin, Vancomin, Methycobal, Cobametin) is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis.",1344.38,"13422-55-4",{"v":100,"d":"100.00"},74.38,"N/A","N/A","http://selleckchem.com/products/methylcobalamin.html","C63H91CoN13O14P","inner salt","Mecobalamin, Vancomin, Methycobal, Cobametin","C[Co+]N1\\C2=C(C)/C3=N\\C(=C/C4=NC(=C(C)/C5=NC(C(CC(N)=O)C5(C)CCC(=O)NCC(C)O[P]([O-])(=O)OC6C(O)C(OC6CO)[N]7C=NC8=C7C=C(C)C(=C8)C)C1(C)C(C)(CC(N)=O)C2CCC(N)=O)\\C(CCC(N)=O)C4(C)C)C(CCC(N)=O)C3(C)CC(N)=O",-0.736,14,9,27]
["S4996","Tavaborole (AN-2690)","f2","L3900-20","in 10mM DMSO","Fungal","Microbiology","Tavaborole (AN-2690) is a boron-containing small molecule with broad spectrum antifungal activity.",151.93,"174671-46-6",{"v":30,"d":"30.00"},197.46,"<1","N/A","http://selleckchem.com/products/tavaborole-an-2690.html","C7H6BFO2","free base","N/A","OB1OCC2=CC(=CC=C12)F",2.305,1,0,0]
["S4999","Avermectin B1","g2","L3900-20","in 10mM DMSO","Parasite","Microbiology","Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.",873.08,"71751-41-2",{"v":100,"d":"100.00"},114.54,"N/A","N/A","http://selleckchem.com/products/avermectin.html","C48H72O14","Macrocyclic lactones","abamectin","CCC(C)C1OC2(CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2)C=CC1C",4.692,11,2,8]
["S5001","Tofacitinib (CP-690550) Citrate","h2","L3900-20","in 10mM DMSO","Anti-infection,JAK","JAK/STAT","Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.",504.49,"540737-29-9",{"v":100,"d":"100.00"},198.22,"<1","N/A","http://selleckchem.com/products/CP-690550.html","C16H20N6O.C6H8O7","Citrate","Tasocitinib Citrate,CP-690550","CC1CCN(CC1N(C)C2=C3C=C[NH]C3=NC=N2)C(=O)CC#N.OC(=O)CC(O)(CC(O)=O)C(O)=O",0.193,6,1,8]
["S5002","Fingolimod (FTY720) HCl","a3","L3900-20","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.",{"v":343.9,"d":"343.90"},"162359-56-0",{"v":69,"d":"69.00"},200.64,{"v":69,"d":"69.00"},200.64,"http://selleckchem.com/products/FTY720.html","C19H33NO2.HCl","Hydrochloride","Fingolimod Hydrochloride,FTY720","Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",{"v":4.58,"d":"4.580"},0,3,12]
["S5003","Tacrolimus (FK506)","b3","L3900-20","in 10mM DMSO","Autophagy,FKBP,phosphatase","PI3K/Akt/mTOR","Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.",804.02,"104987-11-3",{"v":94,"d":"94.00"},116.91,"<1","N/A","http://selleckchem.com/products/FK-506-(Tacrolimus).html","C44H69NO12","free base","FK506, FR900506, Fujimycin, Prograf","COC1CC(CCC1O)\\C=C(C)\\C2OC(=O)C3CCCCN3C(=O)C(=O)C4(O)OC(C(CC(C)C/C(=C/C(CC=C)C(=O)CC(O)C2C)C)OC)C(CC4C)OC",4.832,9,2,7]
["S5004","Pimecrolimus","c3","L3900-20","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.",810.45,"137071-32-0",{"v":100,"d":"100.00"},123.39,"<1","N/A","http://selleckchem.com/products/Pimecrolimus.html","C43H68ClNO11","free base","Elidel,SDZ-ASM 981","CCC1/C=C(C)/CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)/C(C)=C/C4CCC(Cl)C(C4)OC",5.971,9,1,6]
["S5005","Cefotiam hydrochloride","d3","L3900-20","in 10mM DMSO","Anti-infection","Microbiology","Cefotiam hydrochloride (Halospor, Pansporin, Pansporine) is the hydrochloride salt form of cefotiam and has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.",598.55,"66309-69-1",{"v":100,"d":"100.00"},167.07,"N/A","N/A","http://selleckchem.com/products/cefotiam-hydrochloride.html","C18H23N9O4S3.2HCl","dihydrochloride","Cefotiam dihydrochloride, Halospor, Pansporin, Pansporine","Cl.Cl.CN(C)CC[N]1N=NN=C1SCC2=C(N3C(SC2)C(NC(=O)CC4=CSC(=N4)N)C3=O)C(O)=O",-2.796,7,2,10]
["S5006","Teprenone","e3","L3900-20","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Teprenone, an acylic polyisoprenoid, that is known as tetraprenylacetone or geranylgeranylacetone, is an anti-ulcer drug, clinically used for gastritis.  Teprenone(Geranylgeranylacetone) is an inducer of heat shock proteins (HSPs) expression.",330.55,"6809-52-5",{"v":66,"d":"66.00"},199.67,"N/A","N/A","http://selleckchem.com/products/teprenone.html","C23H38O","Isoprenoids","Geranylgeranylacetone, Tetraprenylacetone","CC(C)=CCC/C(C)=C/CC\\C(C)=C\\CC\\C(C)=C\\CCC(C)=O",7.413,1,0,12]
["S5007","Delamanid","f3","L3900-20","in 10mM DMSO","Bacterial","Microbiology","Delamanid (OPC-67683) is a new anti-tuberculosis drug with an excellent intracellular bactericidal activity and a high accumulation rate.",534.48,"681492-22-8",{"v":100,"d":"100.00"},{"v":187.1,"d":"187.10"},"<1","N/A","http://selleckchem.com/products/delamanid.html","C25H25F3N4O6","free base","OPC-67683","CC1(COC2=CC=C(C=C2)N3CCC(CC3)OC4=CC=C(OC(F)(F)F)C=C4)C[N]5C=C(N=C5O1)[N+]([O-])=O",6.452,5,0,9]
["S5009","Brivudine","g3","L3900-20","in 10mM DMSO","CMV","Microbiology","Brivudine (BVDU) is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.",333.14,"69304-47-8",{"v":66,"d":"66.00"},198.11,"N/A","N/A","http://selleckchem.com/products/brivudine.html","C11H13BrN2O5","free base","BVDU","OCC1OC(CC1O)N2C=C(\\C=C\\Br)C(=O)NC2=O",-1.034,3,3,3]
["S5010","Indometacin Sodium","h3","L3900-20","in 10mM DMSO","COX","Immunology & Inflammation","Indometacin Sodium (Indomethacin Sodium) is the sodium salt of indomethacin, which is a non-selective, reversible, and competitive inhibitor of cyclooxygenases 1 and 2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects.",433.82,"74252-25-8",{"v":87,"d":"87.00"},200.55,{"v":-1,"d":"-1.00"},-2.31,"https://www.selleckchem.com/products/indometacin-sodium.html","C19H21ClNNaO7","sodium salt trihydrate","Indomethacin Sodium","O.O.O.COC1=CC2=C(C=C1)[N](C(=C2CC(=O)O[Na])C)C(=O)C3=CC=C(Cl)C=C3",3.705,4,0,5]
["S5012","Octenidine Dihydrochloride","a4","L3900-20","in 10mM DMSO","Bacterial","Microbiology","Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.",623.83,"70775-75-6",{"v":60,"d":"60.00"},96.18,"N/A","N/A","http://selleckchem.com/products/octenidine-ihydrochloride.html","C36H62N4.2HCl","Dihydrochloride","N/A","Cl.Cl.CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1",{"v":10.56,"d":"10.560"},2,0,25]
["S5013","Ioversol","b4","L3900-20","in 10mM DMSO","Others","Others","Ioversol is an organoiodine compound used as a radiographic contrast agent.",807.11,"87771-40-2",{"v":100,"d":"100.00"},{"v":123.9,"d":"123.90"},"N/A","N/A","http://selleckchem.com/products/lversol.html","C18H24I3N3O9","Triiodinated benzene","N/A","OCCN(C(=O)CO)C1=C(I)C(=C(I)C(=C1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO",-2.005,3,8,12]
["S5014","Crisaborole (AN2728)","c4","L3900-20","in 10mM DMSO","PDE","Metabolism","Crisaborole (AN2728) is a small-molecule, boron-based, selective PDE4 inhibitor and has broad-spectrum anti-inflammatory activity.",251.05,"906673-24-3",{"v":50,"d":"50.00"},199.16,"N/A","N/A","http://selleckchem.com/products/crisaborole-an2728.html","C14H10BNO3","free base","N/A","OB1OCC2=CC(=CC=C12)OC3=CC=C(C=C3)C#N",3.538,2,0,2]
["S5015","Simeprevir (TMC435)","d4","L3900-20","in 10mM DMSO","HCV Protease","Proteases","Simeprevir (TMC-435, TMC-435350) is a competitive, reversible, macrocyclic, noncovalent hepatitis C virus (HCV) NS3/4A protease inhibitor that acts directly against the hepatitis C virus. It has a medium inhibitory concentration (IC50) <13 nM for all HCV NS3/4A enzymes(genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3.",749.94,"923604-59-5",{"v":100,"d":"100.00"},133.34,"<1","N/A","http://selleckchem.com/products/simeprevir.html","C38H47N5O7S2","free base","TMC-435350","COC1=C(C)C2=NC(=CC(=C2C=C1)OC3CC4C(C3)C(=O)N(C)CCCC\\C=C/C5CC5(NC4=O)C(=O)N[S](=O)(=O)C6CC6)C7=NC(=CS7)C(C)C",4.796,9,2,8]
["S5016","Isoprinosine","e4","L3900-20","in 10mM DMSO","Antiviral,Immunology & Inflammation related","Microbiology","Isoprinosine (Inosine pranobex, Immunovir, Groprinosin, Delimmun) is an immunopharmacologic agent with antiviral activities.",1115.23,"36703-88-5",{"v":100,"d":"100.00"},89.67,{"v":100,"d":"100.00"},89.67,"http://selleckchem.com/products/isoprinosine.html","C10H12N4O5.3C9H9NO3.3C5H13NO","salt","Inosine pranobex, Immunovir, Groprinosin, Delimmun","CC(O)CN(C)C.CC(O)CN(C)C.CC(O)CN(C)C.CC(=O)NC1=CC=C(C=C1)C(O)=O.CC(=O)NC2=CC=C(C=C2)C(O)=O.CC(=O)NC3=CC=C(C=C3)C(O)=O.OCC4OC(C(O)C4O)[N]5C=NC6=C5N=CNC6=O",-9.137,10,10,14]
["S5019","Indobufen","f4","L3900-20","in 10mM DMSO","COX","Immunology & Inflammation","Indobufen (Ibustrin, K 3920) is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.",295.33,"63610-08-2",{"v":59,"d":"59.00"},199.78,"N/A","N/A","http://selleckchem.com/products/indobufen.html","C18H17NO3","free base","Ibustrin, K 3920","CCC(C(O)=O)C1=CC=C(C=C1)N2CC3=C(C=CC=C3)C2=O",3.157,2,0,4]
["S5020","Tilorone dihydrochloride","g4","L3900-20","in 10mM DMSO","Antiviral,IFN","Immunology & Inflammation","Tilorone dihydrochloride is a broad-spectrum, orally active antiviral agent that activates interferon production. It has antitumor, anti-inflammatory properties.",483.47,"27591-69-1",{"v":43,"d":"43.00"},88.94,{"v":96,"d":"96.00"},198.56,"http://selleckchem.com/products/tilorone-dihydrochloride.html","C25H34N2O3.2HCl","dihydrochloride","N/A","Cl.Cl.CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C=C(OCCN(CC)CC)C=C3)C2=O",5.326,3,0,12]
["S5023","Nadolol","h4","L3900-20","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.",{"v":309.4,"d":"309.40"},"42200-33-9",{"v":61,"d":"61.00"},197.16,"N/A","N/A","http://selleckchem.com/products/nadolol.html","C17H27NO4","free base","Corgard, Solgol, Anabet, SQ11725","CC(C)(C)NCC(O)COC1=CC=CC2=C1CC(O)C(O)C2",1.146,1,4,6]
["S5025","Efinaconazole","a5","L3900-20","in 10mM DMSO","Fungal","Microbiology","Efinaconazole (KP-103) is an inhibitor of 14 alpha-demethylase which is involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes.",348.39,"164650-44-6",{"v":69,"d":"69.00"},198.05,"<1","N/A","http://selleckchem.com/products/efinaconazole.html","C18H22F2N4O","free base","KP-103","CC(N1CCC(=C)CC1)C(O)(C[N]2C=NC=N2)C3=CC=C(F)C=C3F",2.624,2,0,5]
["S5027","Mebeverine Hydrochloride","b5","L3900-20","in 10mM DMSO","Others","Others","Mebeverine (Duspatalin, Duspatal, Colofac), a 3-phenylethylamine derivative of methoxybenzamine, acts as a musculotropic antispasmodic agent.",466.01,"2753-45-9",{"v":93,"d":"93.00"},199.57,"N/A","N/A","http://selleckchem.com/products/mebeverine-hydrochlo.html","C25H35NO5.HCl","hydrochloride","Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride","Cl.CCN(CCCCOC(=O)C1=CC=C(OC)C(=C1)OC)C(C)CC2=CC=C(OC)C=C2",{"v":5.43,"d":"5.430"},5,0,14]
["S5030","Dihydralazine sulphate","c5","L3900-20","in 10mM DMSO","Others","Others","Dihydralazine sulphate (Nepresol, Depressan, 1,4-Dihydrazinophthalazine, Hydralazine) is a dihydralazine-l,4-phthalazine derivative and used as an antihypertensive drug.",288.28,"7327-87-9",{"v":6,"d":"6.00"},20.81,{"v":8,"d":"8.00"},27.75,"http://selleckchem.com/products/dihydralazine-sulphate.html","C8H10N6.H2SO4","sulphate","Nepresol; Depressan; 1,4-Dihydrazinophthalazine sulfate; Hydralazine sulfate","N\\N=C1/NN\\C(=N/N)C2=C1C=CC=C2.O[S](O)(=O)=O",{"v":-1.44,"d":"-1.440"},2,4,0]
["S5033","Terconazole","d5","L3900-20","in 10mM DMSO","Fungal","Microbiology","Terconazole (Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470) is a new, broad-spectrum, triazole antifungal agent which is primarily used to treat vaginal fungal infections.",532.46,"67915-31-5",{"v":49,"d":"49.00"},92.03,"<1","N/A","http://selleckchem.com/products/terconazole.html","C26H31Cl2N5O3","free base","Terazol 3, Terazol 7, Triaconazole, Gyno-Terazol,R42470","CC(C)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=NC=N4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",4.949,5,0,8]
["S5034","Melitracen hydrochloride","e5","L3900-20","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.",327.89,"10563-70-9",{"v":65,"d":"65.00"},198.24,{"v":65,"d":"65.00"},198.24,"http://selleckchem.com/products/melitracen-hydrochloride.html","C21H25N.HCl","hydrochloride","Thymeol hydrochloride","Cl.CN(C)CC[CH]=[C]1C2=C(C=CC=C2)[C](C)(C)C3=C1C=CC=C3",5.155,0,0,3]
["S5041","Difloxacin hydrochloride","f5","L3900-20","in 10mM DMSO","Antibiotics","Microbiology","Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic used in veterinary medicine.",435.85,"91296-86-5",{"v":98,"d":"98.00"},224.85,{"v":98,"d":"98.00"},224.85,"http://selleckchem.com/products/difloxacin-hydrochloride.html","C21H19F2N3O3.HCl","hydrochloride","N/A","Cl.CN1CCN(CC1)C2=CC3=C(C=C2F)C(=O)C(=CN3C4=CC=C(F)C=C4)C(O)=O",0.628,2,0,3]
["S5042","Bevantolol hydrochloride","g5","L3900-20","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Bevantolol hydrochloride (NC-1400) is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.",381.89,"42864-78-8",{"v":76,"d":"76.00"},199.01,{"v":52,"d":"52.00"},136.16,"http://selleckchem.com/products/bevantolol-hydrochloride.html","C20H27NO4.HCl","hydrochloride","NC-1400 hydrochloride","Cl.COC1=C(OC)C=C(CCNCC(O)COC2=CC=CC(=C2)C)C=C1",3.645,3,2,10]
["S5049","Thiocolchicoside","h5","L3900-20","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Thiocolchicoside (Thiocolchicine 2-glucoside analog, Coltramyl) is a natural occuring glycoside originated from the flower seeds of superba gloriosa with anti-inflammatory and analgesic properties as well as pronounced convulsant activity. It is also an antagonist of GABAA receptor.",563.62,"602-41-5",{"v":100,"d":"100.00"},177.42,{"v":100,"d":"100.00"},177.42,"http://selleckchem.com/products/thiocolchicoside.html","C27H33NO10S","Phenolic glycosides","Thiocolchicine 2-glucoside analog, Coltramyl","COC1=C(OC)C2=C(CCC(NC(C)=O)C3=CC(=O)C(=CC=C23)SC)C=C1OC4OC(CO)C(O)C(O)C4O",0.446,6,5,7]
["S5052","Granisetron","a6","L3900-20","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.",312.41,"109889-09-0",{"v":11,"d":"11.00"},35.21,"N/A","N/A","http://selleckchem.com/products/granisetron.html","C18H24N4O","Serotonin 5-HT3 receptor","Sancuso, Kevatril, Granisetronum, Sustol","CN1C2CCCC1CC(C2)NC(=O)C3=N[N](C)C4=C3C=CC=C4",2.401,2,1,2]
["S5054","Rifamycin sodium salt","b6","L3900-20","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Rifamycin sodium is an antibacterial drug used for treatment of mycobacterium infections.",719.75,"14897-39-3",{"v":100,"d":"100.00"},138.94,{"v":-1,"d":"-1.00"},-1.39,"https://www.selleckchem.com/products/rifamycin-sodium-salt.html","C37H46NNaO12","Rifamycins","N/A","[Na+].COC1/C=C/OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=C(NC(=O)\\C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(C1C)C(=O)OC)C)C=C4[O-])O",3.125,7,5,3]
["S5055","Milbemycin Oxime","c6","L3900-20","in 10mM DMSO","Parasite","Microbiology","Milbemycin Oxime is a broad spectrum anti-parasitic drug that is active against worms (anthelmintic) and mites (miticide).","N/A","129496-10-2",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"<1","N/A","http://selleckchem.com/products/milbemycin-oxime.html","C30H40NO7R2","Macrocyclic lactones","N/A","CC1C(OC2(CC1)CC3CC(C/C=C(C)/CC(C)\\C=C\\C=C\\4COC5/C(=N/O)C(=CC(C(=O)O3)C45O)C)O2)[R]",4.783,6,0,0]
["S5058","Revaprazan Hydrochloride","d6","L3900-20","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.",{"v":398.9,"d":"398.90"},"178307-42-1",{"v":16,"d":"16.00"},40.11,"N/A","N/A","http://selleckchem.com/products/revaprazan-hydrochloride.html","C22H23FN4.HCl","HCl","YH1885","Cl.CC1N(CCC2=C1C=CC=C2)C3=NC(=NC(=C3C)C)NC4=CC=C(F)C=C4",6.215,2,1,3]
["S5059","Pixantrone Maleate","e6","L3900-20","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.",557.51,"144675-97-8",{"v":100,"d":"100.00"},179.37,{"v":100,"d":"100.00"},179.37,"http://selleckchem.com/products/pixantrone-maleate.html","C17H19N5O2.2C4H4O4","dimaleate","BBR-2778","NCCNC1=CC=C(NCCN)C2=C1C(=O)C3=C(C=NC=C3)C2=O.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",-5.263,7,4,10]
["S5060","Metadoxine","f6","L3900-20","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.  Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.",298.29,"74536-44-0",{"v":59,"d":"59.00"},197.79,"N/A","N/A","http://selleckchem.com/products/metadoxine.html","C8H11NO3.C5H7NO3","salt","Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat","CC1=C(O)C(=C(CO)C=N1)CO.OC(=O)C2CCC(=O)N2",-1.243,3,4,3]
["S5062","Daclatasvir Dihydrochloride","g6","L3900-20","in 10mM DMSO","HCV Protease","Microbiology","Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection.",{"v":811.8,"d":"811.80"},"1009119-65-6",{"v":100,"d":"100.00"},123.18,{"v":100,"d":"100.00"},123.18,"https://www.selleckchem.com/products/daclatasvir-dihydrochloride.html","C40H50N8O6.2HCl","dihydrochloride","N/A","Cl.Cl.COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C([NH]5)C6CCCN6C(=O)C(NC(=O)OC)C(C)C",5.812,8,4,13]
["S5063","Trelagliptin succinate","h6","L3900-20","in 10mM DMSO","DPP","Proteases","Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).",475.47,"1029877-94-8",{"v":95,"d":"95.00"},{"v":199.8,"d":"199.80"},{"v":95,"d":"95.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/trelagliptin-succinate.html","C18H20FN5O2.C4H6O4","succinate","SYR472","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC(=CC=C3C#N)F)C1=O.OC(=O)CCC(O)=O",-1.362,4,1,6]
["S5065","Ganciclovir sodium","a7","L3900-20","in 10mM DMSO","CMV","Microbiology","Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).",277.21,"107910-75-8",{"v":55,"d":"55.00"},198.41,{"v":55,"d":"55.00"},198.41,"https://www.selleckchem.com/products/ganciclovir-sodium.html","C9H12N5NaO4","Nucleoside","RS-21592 sodium, Cytovene IV sodium, BW 759 sodium, 2'-Nor-2'-deoxyguanosine sodium","[Na+].NC1=NC2=C(N=C[N]2COC(CO)CO)C(=N1)[O-]",-1.859,4,3,5]
["S5066","Pramipexole dihydrochloride","b7","L3900-20","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.",284.25,"104632-25-9",{"v":56,"d":"56.00"},197.01,"N/A","N/A","http://selleckchem.com/products/pramipexole-dihydrochloride.html","C10H17N3S.2HCl","dihydrochloride","SND919","Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",2.147,1,2,3]
["S5067","Losartan","c7","L3900-20","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Losartan(DuP-753) is a selective, orally administered, nonpeptide blocker of angiotensin II type 1 (AT1) receptor used to treat high blood pressure, diabetic kidney disease, heart failure, and left ventricular enlargement.",422.91,"114798-26-4",{"v":84,"d":"84.00"},198.62,{"v":-1,"d":"-1.00"},-2.36,"https://www.selleckchem.com/products/losartan.html","C22H23ClN6O","free base","DuP-753","CCCCC1=NC(=C(CO)[N]1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4)Cl",4.241,4,2,8]
["S5069","Dabrafenib Mesylate","d7","L3900-20","in 10mM DMSO","Raf","MAPK","Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.8 nM, 3.2 nM and 5 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.",615.67,"1195768-06-9",{"v":100,"d":"100.00"},162.42,"<1","N/A","http://selleckchem.com/products/dabrafenib-mesylate.html","C23H20F3N5O2S2.CH4O3S","mesylate","GSK2118436 Mesylate","CC(C)(C)C1=NC(=C(S1)C2=CC=NC(=N2)N)C3=C(F)C(=CC=C3)N[S](=O)(=O)C4=C(F)C=CC=C4F.C[S](O)(=O)=O",4.963,5,2,6]
["S5070","Mupirocin calcium","e7","L3900-20","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic.",1075.34,"115074-43-6",{"v":100,"d":"100.00"},92.99,{"v":6,"d":"6.00"},5.58,"http://selleckchem.com/products/mupirocin-calcium.html","C52H86CaO18.2H2O","calcium salt dihydrate","Pseudomonic acid A","O.O.CC(O)C(C)C1OC1CC2COC(C\\C(C)=C\\C(=O)OCCCCCCCCC(=O)O[Ca]OC(=O)CCCCCCCCOC(=O)\\C=C(C)\\CC3OCC(CC4OC4C(C)C(C)O)C(O)C3O)C(O)C2O",5.246,12,6,38]
["S5071","Duloxetine","f7","L3900-20","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.",297.41,"116539-59-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/duloxetine.html","C18H19NOS","free base","LY-248686","CNCCC(OC1=CC=CC2=CC=CC=C12)C3=CC=CS3",3.846,1,1,6]
["S5073","Donepezil","g7","L3900-20","in 10mM DMSO","AChR","Neuronal Signaling","Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.",379.49,"120014-06-4",{"v":75,"d":"75.00"},197.63,"N/A","N/A","http://selleckchem.com/products/donepezil.html","C24H29NO3","free base","Aricept, Donepezilo","COC1=CC2=C(C=C1OC)C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)C2",4.569,3,0,6]
["S5074","Argatroban Monohydrate","h7","L3900-20","in 10mM DMSO","Thrombin","Proteases","Argatroban (Argatroban hydrate, Argipidine,MCI-9038 Monohydrate) is a direct, selective thrombin inhibitor with anticoagulant effects.",526.65,"141396-28-3",{"v":100,"d":"100.00"},189.88,"<1","N/A","http://selleckchem.com/products/argatroban-monohydrate.html","C23H36N6O5S.H2O","Thrombin inhibitors","Argatroban hydrate, Argipidine,MCI-9038 Monohydrate","O.CC1CCN(C(C1)C(O)=O)C(=O)C(CCCNC(N)=N)N[S](=O)(=O)C2=CC=CC3=C2NCC(C)C3",1.059,4,4,10]
["S5075","Acotiamide","a8","L3900-20","in 10mM DMSO","AChR","Neuronal Signaling","Acotiamide (Acofide, Z388) is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.",450.55,"185106-16-5",{"v":90,"d":"90.00"},199.76,"<1","N/A","http://selleckchem.com/products/acotiamide.html","C21H30N4O5S","free base","Acofide, Z388","COC1=C(OC)C=C(C(=O)NC2=NC(=CS2)C(=O)NCCN(C(C)C)C(C)C)C(=C1)O",2.565,5,3,10]
["S5077","Regorafenib (BAY-734506) Monohydrate","b8","L3900-20","in 10mM DMSO","c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, Kit (c-Kit), RET (c-RET), RAF-1, B-RAF and B-RAF(V600E) respectively.",500.83,"1019206-88-2",{"v":100,"d":"100.00"},199.67,"N/A","N/A","http://selleckchem.com/products/regorafenib-monohydrate.html","C21H15ClF4N4O3.H2O","monohydrate","Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate","O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F",4.174,4,3,6]
["S5078","Osimertinib mesylate","c8","L3900-20","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.",595.71,"1421373-66-1",{"v":9,"d":"9.00"},15.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/osimertinib-mesylate.html","C29H37N7O5S","mesylate","AZD9291 mesylate","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C.C[S](O)(=O)=O",4.257,4,2,10]
["S5079","Sitagliptin","d8","L3900-20","in 10mM DMSO","DPP","Proteases","Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.",407.31,"486460-32-6",{"v":81,"d":"81.00"},198.87,"N/A","N/A","http://selleckchem.com/products/sitagliptin.html","C16H15F6N5O","free base","MK-0431","NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F",{"v":1.93,"d":"1.930"},3,1,5]
["S5082","Vitamin K2","e8","L3900-20","in 10mM DMSO","Vitamin","Metabolism","Vitamin K2 (Menaquinone) is an important fat-soluble vitamin that plays critical roles in protecting heart and brain, and building strong bones. It also plays an important role in cancer protection.",444.65,"863-61-6",{"v":88,"d":"88.00"},197.91,"N/A","N/A","http://selleckchem.com/products/vitamin-k2.html","C31H40O2","free base","Menaquinone","CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O",{"v":9.5,"d":"9.500"},2,0,11]
["S5083","Lentinan","f8","L3900-20","in 10mM DMSO","Fungal,Immunology & Inflammation related","Immunology & Inflammation","Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.","N/A","37339-90-5",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/lentinan.html","C42H70O35R2","Polysaccharides","A823605, Bromoduline","O(C1C(O)C(CO)OC(OCC2OC(OC3C(O)C(CO)OC(OC4C(O)C(COC5OC(CO)C(O)C(O)C5O)OC(OC6C(O)C(OC(CO)C6O)[*])C4O)C3O)C(O)C(OC7OC(CO)C(O)C(O)C7O)C2O)C1O)[*]",-10.494,14,21,20]
["S5091","Geranyl acetate","g8","L3900-20","in 10mM DMSO","Others","Apoptosis","Geranyl acetate (Geraniol acetate, Geranyl ethanoate) is a natural organic compound that is used primarily as a component of perfumes for creams and soaps and as a flavoring ingredient. Geranyl acetate exhibits anti-cancer effects by inducing cell apoptosis.",196.29,"105-87-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/geranyl-acetate.html","C12H20O2","free base","Geraniol acetate, Geranyl ethanoate","CC(=O)OC/C=C(C)/CCC=C(C)C",3.313,2,0,6]
["S5100","Pralidoxime Iodide","h8","L3900-20","in 10mM DMSO","AChR","Neuronal Signaling","Pralidoxime Iodide (2-PAM) is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.",264.06,"94-63-3",{"v":52,"d":"52.00"},196.92,"N/A","N/A","http://selleckchem.com/products/pralidoxime-lodide.html","C7H9N2O.I","iodide salt","2-PAM","[I-].C[N+]1=C(C=CC=C1)\\C=N\\O",{"v":-1.56,"d":"-1.560"},1,0,1]
["S5106","Lanolin","a9","L3900-20","in 10mM DMSO","Others","Others","Lanolin (wool wax, wool grease) is a wax secreted by the sebaceous glands of wool-bearing animals and used widely in the pharmaceutical and cosmetics industries.","N/A","8006-54-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/lanolin.html","N/A","Lipids","wool wax, wool grease","N/A",{"v":0,"d":"0.000"},0,0,0]
["S5109","Ademetionine","b9","L3900-20","in 10mM DMSO","Others","Others","Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.",398.44,"29908-03-0",{"v":79,"d":"79.00"},198.27,"N/A","N/A","http://selleckchem.com/products/ademetionine.html","C15H22N6O5S","free base","AdoMet, S-Adenosylmethionine, SAMe","C[S+](CCC(N)C([O-])=O)CC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N",{"v":0,"d":"0.000"},0,0,0]
["S5130","Taurocholic acid sodium salt hydrate","c9","L3900-20","in 10mM DMSO","Others","Others","Taurocholic acid (Sodium taurocholate hydrate), a bile salt formed in the liver, is the product of conjugation of cholic acid with taurine that is involved in the emulsification of lipids. Its sodium salt is the chief ingredient of the bile of carnivorous animals.","537.68 (anhydrous basis)","345909-26-4",{"v":100,"d":"100.00"},185.98,"N/A","N/A","http://selleckchem.com/products/taurocholic-acid-sodium-salt-hydrate.html","C26H45NO7S.xH2O.Na","sodium salt, hydrate","Sodium taurocholate hydrate","[Na+].CC(CCC(=O)NCC[S]([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",{"v":0,"d":"0.000"},0,0,0]
["S5145","Protoporphyrin IX","d9","L3900-20","in 10mM DMSO","Others","Others","Protoporphyrin IX (PPIX) is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.",562.66,"553-12-8",{"v":100,"d":"100.00"},177.73,"N/A","N/A","http://selleckchem.com/products/protoporphyrin-ix.html","C34H34N4O4","free base","PPIX","CC1=C2[NH]C(=C1CCC(O)=O)C=C3N=C(C=C4N=C(C=C5[NH]C(=C2)C(=C5C)C=C)C(=C4C)C=C)C(=C3CCC(O)=O)C",{"v":0,"d":"0.000"},0,0,0]
["S5154","Tetrahydropiperine","e9","L3900-20","in 10mM DMSO","Others","Others","Tetrahydropiperine (Cosmoperine), derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.",289.37,"23434-88-0",{"v":57,"d":"57.00"},196.98,"N/A","N/A","http://selleckchem.com/products/tetrahydropiperine.html","C17H23NO3","free base","Cosmoperine","O=C(CCCCC1=CC2=C(OCO2)C=C1)N3CCCCC3",3.332,3,0,5]
["S5157","Thymol","f9","L3900-20","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.",150.22,"89-83-8",{"v":30,"d":"30.00"},199.71,"N/A","N/A","http://selleckchem.com/products/thymol.html","C10H14O","free base","2-isopropyl-5-methylphenol, IPMP","CC(C)C1=CC=C(C)C=C1O",{"v":0,"d":"0.000"},0,0,0]
["S5159","Doxycycline","g9","L3900-20","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,MMP","Microbiology","Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.",444.43,"564-25-0",{"v":88,"d":"88.00"},198.01,"N/A","N/A","http://selleckchem.com/products/doxycycline.html","C22H24N2O8","free base","Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum","CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5174","Kojic acid","h9","L3900-20","in 10mM DMSO","Fungal,Tyrosinase","Proteases","Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.",142.11,"501-30-4",{"v":28,"d":"28.00"},197.03,"N/A","N/A","http://selleckchem.com/products/kojic-acid.html","C6H6O4","free base","N/A","OCC1=CC(=O)C(=CO1)O",{"v":0,"d":"0.000"},0,0,0]
["S5177","Naproxen","a10","L3900-20","in 10mM DMSO","COX","Immunology & Inflammation","Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.",230.26,"22204-53-1",{"v":46,"d":"46.00"},199.77,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/naproxen.html","C14H14O3","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(O)=O",2.849,2,0,3]
["S5179","Ropivacaine Mesilate","b10","L3900-20","in 10mM DMSO","Others","Others","Ropivacaine Mesilate is the mesylate form of ropivacaine, which is a member of the amino amide class of local anesthetics.",370.51,"854056-07-8",{"v":74,"d":"74.00"},199.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ropivacaine-mesilate.html","C18H30N2O4S","Mesilate","Ropivacaine Mesylate","CCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C.C[S](O)(=O)=O",{"v":3.44,"d":"3.440"},1,1,4]
["S5200","Diaveridine","c10","L3900-20","in 10mM DMSO","DHFR","Metabolism","Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.",260.29,"5355-16-8",{"v":25,"d":"25.00"},96.05,"N/A","N/A","http://selleckchem.com/products/diaveridine.html","C13H16N4O2","free base","AI3-23935, CCRIS-3784","COC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1",1.559,4,2,4]
["S5205","Nilotinib hydrochloride","d10","L3900-20","in 10mM DMSO","Bcr-Abl","Angiogenesis","Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.",565.98,"923288-95-3",{"v":100,"d":"100.00"},176.69,{"v":-1,"d":"-1.00"},-1.77,"http://selleckchem.com/products/nilotinib-hydrochloride.html","C28H22F3N7O.HCl","hydrochloride","AMN-107 HCl","Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",5.466,5,2,7]
["S5206","Benzylpenicillin potassium","e10","L3900-20","in 10mM DMSO","Antibiotics","Microbiology","Benzylpenicillin potassium (Penicillin G potassium) is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic.",372.48,"113-98-4",{"v":74,"d":"74.00"},198.67,"N/A","N/A","http://selleckchem.com/products/benzylpenicillin-potassium.html","C16H17N2O4S.K","potassium salt","Penicillin G potassium","[K+].CC1(C)SC2C(NC(=O)CC3=CC=CC=C3)C(=O)N2C1C([O-])=O",{"v":-0.35,"d":"-0.350"},2,1,4]
["S5208","Ciprofloxacin hydrochloride hydrate","f10","L3900-20","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox,Bay-09867 hydrochloride hydrate) is the hydrochloride salt form of ciprofloxacin, which is an antibiotic used to treat a number of bacterial infections.",385.82,"86393-32-0",{"v":8,"d":"8.00"},20.74,"N/A","N/A","http://selleckchem.com/products/ciprofloxacin-hydrochloride-hydrate.html","C17H18FN3O3.HCl.H2O","hydrochloride hydrate","Ciloxan, Ceprimax, Oftacilox,Bay-09867 hydrochloride hydrate","O.Cl.OC(=O)C1=CN(C2CC2)C3=C(C=C(F)C(=C3)N4CCNCC4)C1=O",-1.095,2,1,3]
["S5211","4-Aminosalicylic acid","g10","L3900-20","in 10mM DMSO","Bacterial","Microbiology","4-Aminosalicylic acid (Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate) is an antitubercular agent with bacteriostatic activity against Mycobacterium tuberculosis.",153.14,"65-49-6",{"v":10,"d":"10.00"},{"v":65.3,"d":"65.30"},"N/A","N/A","http://selleckchem.com/products/4-aminosalicylic-acid.html","C7H7NO3","free base","Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate","NC1=CC(=C(C=C1)C(O)=O)O",0.471,1,2,1]
["S5215","Abacavir (1592U89)","h10","L3900-20","in 10mM DMSO","Reverse Transcriptase","Microbiology","Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.",286.33,"136470-78-5",{"v":57,"d":"57.00"},199.07,"N/A","N/A","http://selleckchem.com/products/abacavir.html","C14H18N6O","free base","N/A","NC1=NC2=C(N=C[N]2C3CC(CO)C=C3)C(=N1)NC4CC4",0.769,3,3,4]
["S5217","Arformoterol Tartrate","a11","L3900-20","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.",494.49,"200815-49-2",{"v":99,"d":"99.00"},200.21,{"v":-1,"d":"-1.00"},-2.02,"https://www.selleckchem.com/products/arformoterol-tartrate.html","C23H30N2O10","Tartrate","(R, R)-Formoterol","COC1=CC=C(CC(C)NCC(O)C2=CC(=C(O)C=C2)NC=O)C=C1.OC(C(O)C(O)=O)C(O)=O",-2.446,4,6,11]
["S5222","Coluracetam","b11","L3900-20","in 10mM DMSO","GluR","Neuronal Signaling","Coluracetam (BCI-540, MKC-231) is a nootropic belonging to the racetam family of drugs with cognitive enhancing and neuroprotective effects.",{"v":341.4,"d":"341.40"},"135463-81-9",{"v":68,"d":"68.00"},199.18,"<1","N/A","http://selleckchem.com/products/coluracetam.html","C19H23N3O3","free base","MKC-231, BCI-540","CC1=C(C)C2=C(O1)N=C3CCCCC3=C2NC(=O)CN4CCCC4=O",1.975,4,1,3]
["S5227","Erythromycin thiocyanate","c11","L3900-20","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits and inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.",793.02,"7704-67-8",{"v":100,"d":"100.00"},{"v":126.1,"d":"126.10"},"N/A","N/A","http://selleckchem.com/products/erythromycin-thiocyanate.html","C37H67NO13.CHNS","thiocyanate","N/A","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O.SC#N",2.337,8,3,7]
["S5228","Minoxidil sulphate","d11","L3900-20","in 10mM DMSO","Others","Others","Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.",289.31,"83701-22-8",{"v":57,"d":"57.00"},197.02,"N/A","N/A","http://selleckchem.com/products/minoxidil-sulphate.html","C9H15N5O4S","free base","U-58838","NC1=NC(=CC(=N)N1O[S](O)(=O)=O)N2CCCCC2",{"v":0.35,"d":"0.350"},2,1,3]
["S5229","Isosorbide dinitrate","e11","L3900-20","in 10mM DMSO","Guanylate Cyclase,NOS","Immunology & Inflammation","Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).",236.14,"87-33-2",{"v":47,"d":"47.00"},199.03,"N/A","N/A","http://selleckchem.com/products/isosorbide-dinitrate.html","C6H8N2O8","free base","Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide","[O-][N+](=O)OC1COC2C(COC12)O[N+]([O-])=O",3.413,4,0,4]
["S5233","Fenretinide (NSC 374551)","f11","L3900-20","in 10mM DMSO","Retinoid Receptor","Metabolism","Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.",391.55,"65646-68-6",{"v":78,"d":"78.00"},199.21,"<1","N/A","http://selleckchem.com/products/fenretinide.html","C26H33NO2","free base","4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(=O)NC2=CC=C(O)C=C2)C(C)(C)CCC1",6.463,1,2,6]
["S5234","Nintedanib Ethanesulfonate Salt","g11","L3900-20","in 10mM DMSO","FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.",649.76,"656247-18-6",{"v":100,"d":"100.00"},{"v":153.9,"d":"153.90"},{"v":100,"d":"100.00"},{"v":153.9,"d":"153.90"},"http://selleckchem.com/products/nintedanib-ethanesulfonate-salt.html","C31H33N5O4.C2H6O3S","ethanesulfonate","Intedanib, BIBF 1120","CC[S](O)(=O)=O.COC(=O)C1=CC2=C(C=C1)C(/C(=O)N2)=C(NC3=CC=C(C=C3)N(C)C(=O)CN4CCN(C)CC4)\\C5=CC=CC=C5",{"v":2.9,"d":"2.900"},4,2,9]
["S5238","Solifenacin (YM905)","h11","L3900-20","in 10mM DMSO","AChR","Neuronal Signaling","Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.",362.46,"242478-37-1",{"v":72,"d":"72.00"},198.64,{"v":-1,"d":"-1.00"},-2.76,"https://www.selleckchem.com/products/solifenacin.html","C23H26N2O2","free base","N/A","O=C(OC1CN2CCC1CC2)N3CCC4=C(C=CC=C4)C3C5=CC=CC=C5",4.029,2,0,3]
["S5239","Paroxetine mesylate","a2","L3900-21","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.",425.47,"217797-14-3",{"v":85,"d":"85.00"},199.78,{"v":-1,"d":"-1.00"},-2.35,"http://selleckchem.com/products/paroxetine-mesylate.html","C19H20FNO3.CH4O3S","Mesylate","BRL-29060A mesylate,FG-7051 mesylate","C[S](O)(=O)=O.FC1=CC=C(C=C1)C2CCNCC2COC3=CC=C4OCOC4=C3",2.815,3,1,4]
["S5240","Lenvatinib (E7080) Mesylate","b2","L3900-21","in 10mM DMSO","c-Kit,c-RET,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Lenvatinib Mesylate (E7080) is a synthetic, orally available tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet-derived growth factor receptor α (PDGFRα), stem cell factor receptor (Kit (c-Kit)), and rearranged during transfection (RET (c-RET)). Lenvatinib Mesylate has potential antineoplastic activity.",522.96,"857890-39-2",{"v":39,"d":"39.00"},74.58,{"v":-1,"d":"-1.00"},-1.91,"http://selleckchem.com/products/lenvatinib-mesylate.html","C21H19ClN4O4.CH4O3S","Mesylate","E7080 mesylate","COC1=C(C=C2C(=CC=NC2=C1)OC3=CC(=C(NC(=O)NC4CC4)C=C3)Cl)C(N)=O.C[S](O)(=O)=O",2.418,5,3,6]
["S5241","Lapatinib ditosylate monohydrate","c2","L3900-21","in 10mM DMSO","HER2","Protein Tyrosine Kinase","Lapatinib ditosylate monohydrate (Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate)is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways, used for treatment of solid tumours such as breast and lung cancer.",943.48,"388082-78-8",{"v":100,"d":"100.00"},105.99,{"v":-1,"d":"-1.00"},-1.06,"https://www.selleckchem.com/products/lapatinib-ditosylate-monohydrate.html","C43H44ClFN4O11S3","ditosylate monohydrate","Lapatinib ditoluenesulfonate monohydrate, Lapatinib tosilate, Lapatinib tosilate hydrate","O.CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC5=C(C=C4)N=CN=C5NC6=CC(=C(OCC7=CC(=CC=C7)F)C=C6)Cl",9.132,6,2,13]
["S5242","Cediranib Maleate","d2","L3900-21","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Cediranib Maleate (AZD-2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.",566.58,"857036-77-2",{"v":100,"d":"100.00"},{"v":176.5,"d":"176.50"},"<1","N/A","http://selleckchem.com/products/cediranib-maleate.html","C25H27FN4O3.C4H4O4","maleate","AZD-2171 maleate","COC1=CC2=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)N=CN=C2C=C1OCCCN5CCCC5.OC(=O)\\C=C/C(O)=O",1.765,7,1,10]
["S5243","Ruxolitinib Phosphate","e2","L3900-21","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",404.36,"1092939-17-7",{"v":80,"d":"80.00"},197.84,{"v":29,"d":"29.00"},71.72,"http://selleckchem.com/products/ruxolitinib-phosphate.html","C17H18N6.H3O4P","phosphate","INCB018424, INC424","O[P](O)(O)=O.N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",2.412,3,1,4]
["S5245","Raltegravir potassium","f2","L3900-21","in 10mM DMSO","Integrase","Microbiology","Raltegravir Potassium(MK-0518 potassium) is the orally bioavailable potassium salt of raltegravir, the first approved human immunodeficiency virus type 1 (HIV-1) integrase inhibitor.",482.51,"871038-72-1",{"v":96,"d":"96.00"},198.96,"<1","N/A","http://selleckchem.com/products/raltegravir-potassium.html","C20H20FN6O5.K","potassium salt","MK-0518 potassium","[K+].CN1C(=O)C(=C(N=C1C(C)(C)NC(=O)C2=NN=C(C)O2)C(=O)NCC3=CC=C(F)C=C3)[O-]",-0.994,7,2,6]
["S5246","Entecavir","g2","L3900-21","in 10mM DMSO","Reverse Transcriptase","Microbiology","Entecavir(BMS200475,SQ34676), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).",277.28,"142217-69-4",{"v":55,"d":"55.00"},198.36,"<1","N/A","https://www.selleckchem.com/products/s5246-entecavir.html","C12H15N5O3","free base","BMS200475,SQ34676","NC1=NC(=O)C2=C(N1)[N](C=N2)C3CC(O)C(CO)C3=C",-1.404,3,4,2]
["S5250","Darunavir","h2","L3900-21","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.",547.66,"206361-99-1",{"v":100,"d":"100.00"},{"v":182.6,"d":"182.60"},"<1","N/A","http://selleckchem.com/products/darunavir.html","C27H37N3O7S","free base","TMC114,DRV","CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2COC3OCCC23)[S](=O)(=O)C4=CC=C(N)C=C4",2.631,6,3,12]
["S5253","Cisapride (R 51619)","a3","L3900-21","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.",465.95,"81098-60-4",{"v":93,"d":"93.00"},199.59,"<1","N/A","http://selleckchem.com/products/cisapride.html","C23H29ClFN3O4","Benzamide","Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid","COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C3=C(OC)C=C(N)C(=C3)Cl",2.785,4,2,9]
["S5254","Dasatinib hydrochloride","b3","L3900-21","in 10mM DMSO","Bcr-Abl,kit,Src","Angiogenesis","Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.",524.47,"854001-07-3",{"v":100,"d":"100.00"},190.67,{"v":11,"d":"11.00"},20.97,"https://www.selleckchem.com/products/dasatinib-hydrochloride.html","C22H27Cl2N7O2S","hydrochloride","BMS-354825 HCl","Cl.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.821,4,3,7]
["S5255","Nicardipine","c3","L3900-21","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nicardipine is a potent calcium channel blockader with marked vasodilator action.",479.52,"55985-32-5",{"v":95,"d":"95.00"},198.11,{"v":30,"d":"30.00"},62.56,"https://www.selleckchem.com/products/nicardipine.html","C26H29N3O6","Dihydropyridine calcium channel blocker","YC-93","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",3.488,4,1,11]
["S5257","Doxapram","d3","L3900-21","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Doxapram is a central respiratory stimulant with a brief duration of action. Doxapram is a selective TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel inhibitor with EC50 of 410 nM, 37 μM, 9 μM, respectively.",378.51,"309-29-5",{"v":75,"d":"75.00"},198.15,"<1","N/A","http://selleckchem.com/products/doxapram.html","C24H30N2O2","free base","N/A","CCN1CC(CCN2CCOCC2)C(C1=O)(C3=CC=CC=C3)C4=CC=CC=C4",3.043,2,0,6]
["S5258","Revefenacin","e3","L3900-21","in 10mM DMSO","AChR","Neuronal Signaling","Revefenacin (TD-4208, GSK-1160724) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.",597.75,"864750-70-9",{"v":100,"d":"100.00"},167.29,"<1","N/A","http://selleckchem.com/products/revefenacin.html","C35H43N5O4","Quinuclidinyl","TD-4208, GSK-1160724","CN(CCN1CCC(CC1)OC(=O)NC2=CC=CC=C2C3=CC=CC=C3)C(=O)C4=CC=C(CN5CCC(CC5)C(N)=O)C=C4",3.833,4,2,11]
["S5266","Stiripentol","f3","L3900-21","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.",234.29,"49763-96-4",{"v":46,"d":"46.00"},196.34,{"v":13,"d":"13.00"},55.49,"http://selleckchem.com/products/stiripentol.html","C14H18O3","Dioxolane","BCX2600","CC(C)(C)C(O)/C=C/C1=CC=C2OCOC2=C1",2.955,2,1,3]
["S5268","Solithromycin","g3","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.",845.01,"760981-83-7",{"v":100,"d":"100.00"},118.34,"<1","N/A","http://selleckchem.com/products/solithromycin.html","C43H65FN6O10","free base","CEM-101, OP-1068","CCC1OC(=O)C(C)(F)C(=O)C(C)C(OC2OC(C)CC(C2O)N(C)C)C(C)(CC(C)C(=O)C(C)C3N(CCCC[N]4C=C(N=N4)C5=CC=CC(=C5)N)C(=O)OC13C)OC",4.802,11,2,11]
["S5269","J147","h3","L3900-21","in 10mM DMSO","MAO","Neuronal Signaling","J147, a curcumin derivative, is a potent neurogenic and neuroprotective compound developed for the treatment of neurodegenerative conditions associated with aging.",350.33,"1146963-51-0",{"v":70,"d":"70.00"},199.81,"N/A","N/A","http://selleckchem.com/products/j147.html","C18H17F3N2O2","free base","N/A","COC1=CC(=CC=C1)/C=N/N(C(=O)C(F)(F)F)C2=CC=C(C)C=C2C",4.845,3,0,5]
["S5273","Canrenone","a4","L3900-21","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.",340.46,"976-71-6",{"v":68,"d":"68.00"},199.73,"N/A","N/A","http://selleckchem.com/products/canrenone.html","C22H28O3","free base","Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone","CC12CCC(=O)C=C1C=CC3C2CCC4(C)C3CCC45CCC(=O)O5",3.519,3,0,0]
["S5274","GS967","b4","L3900-21","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.",347.22,"1262618-39-2",{"v":45,"d":"45.00"},{"v":129.6,"d":"129.60"},"<1","N/A","http://selleckchem.com/products/gs967.html","C14H7F6N3O","free base","GS458967","FC(F)(F)OC1=CC=C(C=C1)C2=C[N]3C(=NN=C3C(F)(F)F)C=C2",5.307,3,0,4]
["S5278","Tedizolid (TR-700)","c4","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Tedizolid(TR-700) is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.",370.34,"856866-72-3",{"v":10,"d":"10.00"},{"v":27,"d":"27.00"},{"v":-1,"d":"-1.00"},{"v":-2.7,"d":"-2.70"},"https://www.selleckchem.com/products/tedizolid.html","C17H15FN6O3","Oxazolidinone","N/A","C[N]1N=NC(=N1)C2=CC=C(C=N2)C3=C(F)C=C(C=C3)N4CC(CO)OC4=O",1.784,6,1,4]
["S5282","Lactitol monohydrate","d4","L3900-21","in 10mM DMSO","Others","Others","Lactitol is an artificial sugar alcohol currently used as a bulk sweetener in calorie-controlled foods.",362.33,"81025-04-9",{"v":72,"d":"72.00"},198.71,"N/A","N/A","http://selleckchem.com/products/lactitol-monohydrate.html","C12H24O11.H2O","hydrate","N/A","O.OCC(O)C(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)CO",-4.895,2,9,8]
["S5284","Adenosine 5'-monophosphate monohydrate","e4","L3900-21","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).",365.24,"18422-05-4",{"v":9,"d":"9.00"},24.64,"N/A","N/A","http://selleckchem.com/products/adenosine-5-monophosphate-monohydrate.html","C10H14N5O7P.H2O","hydrate","5'-Adenylic acid, 5'-AMP","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O",{"v":-2.16,"d":"-2.160"},5,3,4]
["S5285","RU58841","f4","L3900-21","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen.",369.34,"154992-24-2",{"v":73,"d":"73.00"},197.65,"<1","N/A","http://selleckchem.com/products/ru58841.html","C17H18F3N3O3","free base","PSK3841, HMR3841","CC1(C)N(CCCCO)C(=O)N(C1=O)C2=CC=C(C#N)C(=C2)C(F)(F)F",2.548,2,1,6]
["S5286","Ramatroban","g4","L3900-21","in 10mM DMSO","Prostaglandin Receptor","Metabolism","Ramatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells.",416.47,"116649-85-5",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/ramatroban.html","C21H21FN2O4S","free base","BAY u 3405","OC(=O)CC[N]1C2=C(CC(CC2)N[S](=O)(=O)C3=CC=C(F)C=C3)C4=CC=CC=C14",{"v":3.51,"d":"3.510"},3,1,6]
["S5293","Nimustine Hydrochloride","h4","L3900-21","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.",309.15,"55661-38-6",{"v":61,"d":"61.00"},197.32,"N/A","N/A","http://selleckchem.com/products/nimustine-hydrochloride.html","C9H13ClN6O2.HCl","hydrochloride","Nidran hydrochloride","Cl.CC1=NC=C(CNC(=O)N(CCCl)N=O)C(=N1)N",{"v":0.47,"d":"0.470"},4,2,5]
["S5295","Lincomycin Hydrochloride Monohydrate","a5","L3900-21","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture","Microbiology","Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.",461.01,"7179-49-9",{"v":92,"d":"92.00"},199.56,"N/A","N/A","http://selleckchem.com/products/lincomycin-hydrochloride-monohydrate.html","C18H34N2O6S.HCl.H2O","hydrochloride, hydrate","N/A","O.Cl.CCCC1CC(N(C)C1)C(=O)NC(C(C)O)C2OC(SC)C(O)C(O)C2O",0.247,2,5,7]
["S5297","Vidarabine monohydrate","b5","L3900-21","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.",285.26,"24356-66-9",{"v":57,"d":"57.00"},199.82,"N/A","N/A","http://selleckchem.com/products/vidarabine-monohydrate.html","C10H13N5O4.H2O","hydrate","Spongoadenosine monohydrate, Vira-A monohydrate","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-2.088,4,4,2]
["S5298","Amoxicillin trihydrate","c5","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.",419.45,"61336-70-7",{"v":30,"d":"30.00"},71.52,"N/A","N/A","http://selleckchem.com/products/amoxicillin-trihydrate.html","C16H19N3O5S.3H2O","trihydrate","Amoxil trihydrate, Amoxipen trihydrate, Moxaline trihydrate","O.O.O.CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O",-3.161,3,3,4]
["S5299","Tosufloxacin p-Toluenesulfonate Hydrate","d5","L3900-21","in 10mM DMSO","Antibiotics","Microbiology","Tosufloxacin (T-3262) is a fluoroquinolone antibiotic that is used to treat susceptible infections.",594.56,"1400591-39-0",{"v":100,"d":"100.00"},168.19,"N/A","N/A","http://selleckchem.com/products/tosufloxacin-p-toluenesulfonate-hydrate.html","C19H15F3N4O3.C7H8O3S.H2O","4-methylbenzenesulfonate, hy","Tosufloxacin Tosylate Hydrate, T-3262 Tosylate Hydrate","O.CC1=CC=C(C=C1)[S](O)(=O)=O.NC2CCN(C2)C3=NC4=C(C=C3F)C(=O)C(=CN4C5=CC=C(F)C=C5F)C(O)=O",{"v":1.5,"d":"1.500"},3,1,4]
["S5301","Carglumic Acid","e5","L3900-21","in 10mM DMSO","CPSase","Metabolism","Carglumic Acid (arbamylglutamic acid, Carbamino-L-glutamic acid, Ureidoglutaric acid, N-Carbamylglutamate) is an orally active, synthetic structural analogue of N-acetylglutamate (NAG) and carbamoyl phosphate synthetase 1 (CPS 1) activator, with ammonia lowering activity.",190.15,"1188-38-1",{"v":38,"d":"38.00"},199.84,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/carglumic-acid.html","C6H10N2O5","Free Base","Carbamylglutamic acid, Carbamino-L-glutamic acid, Ureidoglutaric acid, N-Carbamylglutamate","NC(=O)NC(CCC(O)=O)C(O)=O",-1.169,3,2,5]
["S5307","PSI-6206 (GS-331007)","f5","L3900-21","in 10mM DMSO","HCV Protease","Proteases","PSI-6206 (RO-2433, GS-331007) is a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase, targeting NS5B polymerase.",260.22,"863329-66-2",{"v":52,"d":"52.00"},199.83,{"v":52,"d":"52.00"},199.83,"http://selleckchem.com/products/psi-6206-ro-2433-gs-331007.html","C10H13FN2O5","free base","RO-2433","CC1(F)C(O)C(CO)OC1N2C=CC(=O)NC2=O",-1.306,3,3,2]
["S5311","Pyridoxal phosphate","g5","L3900-21","in 10mM DMSO","Vitamin","Metabolism","Pyridoxal phosphate (Pyridoxal 5'-phosphate, PAL-P, PLP, Vitamin B6), the active form of vitamin B6, acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.",247.14,"54-47-7",{"v":10,"d":"10.00"},40.46,{"v":6,"d":"6.00"},24.28,"http://selleckchem.com/products/pyridoxal-phosphate.html","C8H10NO6P","free base","pyridoxal 5'-phosphate, PAL-P, PLP, Vitamin B6 phosphate","CC1=NC=C(CO[P](O)(O)=O)C(=C1O)C=O",-0.197,3,1,4]
["S5312","Urolithin A","h5","L3900-21","in 10mM DMSO","Mitophagy","Autophagy","Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.",{"v":228.2,"d":"228.20"},"1143-70-0",{"v":45,"d":"45.00"},{"v":197.2,"d":"197.20"},"<1","N/A","http://selleckchem.com/products/urolithin-a.html","C13H8O4","free base","3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin","OC1=CC=C2C(=C1)OC(=O)C3=CC(=CC=C23)O",2.466,2,2,0]
["S5314","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","a6","L3900-21","in 10mM DMSO","ROS","Immunology & Inflammation","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS), including peroxyl radicals, and scavenging them to form more stable free radicals.",236.35,"148081-72-5",{"v":47,"d":"47.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hthq-1-o-hexyl-2-3-5-trimethylhydroquinone.html","C15H24O2","Hydroquinones","N/A","CCCCCCOC1=CC(=C(O)C(=C1C)C)C",5.271,1,1,6]
["S5316","NU2058","b6","L3900-21","in 10mM DMSO","CDK","Cell Cycle","NU2058 (O(6)-Cyclohexylmethylguanine) is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.",{"v":247.3,"d":"247.30"},"161058-83-9",{"v":49,"d":"49.00"},198.14,"<1","N/A","http://selleckchem.com/products/nu2058.html","C12H17N5O","free base","O(6)-Cyclohexylmethylguanine","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3CCCCC3",2.251,4,2,3]
["S5319","Imepitoin","c6","L3900-21","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Imepitoin(ELB-138,AWD 131-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.  AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.",279.72,"188116-07-6",{"v":30,"d":"30.00"},107.25,"<1","N/A","http://selleckchem.com/products/awd-131-138.html","C13H14ClN3O2","free base","ELB-138,AWD 131-138","ClC1=CC=C(C=C1)N2CC(=NC2=O)N3CCOCC3",{"v":1.44,"d":"1.440"},3,0,2]
["S5321","Y15","d6","L3900-21","in 10mM DMSO","FAK","Angiogenesis","Y15 (1,2,4,5-Benzenetetraamine tetrahydrochloride, FAK inhibitor 14) is a small-molecule FAK scaffolding inhibitor that directly inhibits FAK autophosphorylation in a dose- and time-dependent manner.",284.01,"4506-66-5",{"v":56,"d":"56.00"},197.18,{"v":56,"d":"56.00"},197.18,"http://selleckchem.com/products/y15.html","C6H10N4.4HCl","tetrahydrochloride","1,2,4,5-Benzenetetraamine tetrahydrochloride, FAK inhibitor 14","Cl.Cl.Cl.Cl.NC1=CC(=C(N)C=C1N)N",0.371,0,4,0]
["S5325","Nitisinone","e6","L3900-21","in 10mM DMSO","Others","Metabolism","Nitisinone (NTBC, Nitisone, SC0735) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.",329.23,"104206-65-7",{"v":65,"d":"65.00"},197.43,"<1","N/A","http://selleckchem.com/products/nitisinone.html","C14H10F3NO5","free base","NTBC, Nitisone, SC0735","[O-][N+](=O)C1=CC(=CC=C1C(=O)C2C(=O)CCCC2=O)C(F)(F)F",{"v":2.53,"d":"2.530"},3,0,4]
["S5326","Dolasetron","f6","L3900-21","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Dolasetron(MDL-73147EF) is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors.",324.37,"115956-12-2",{"v":64,"d":"64.00"},197.31,"<1","N/A","https://www.selleckchem.com/products/dolasetron.html","C19H20N2O3","free base","MDL-73147EF","O=C1CN2C3CC(CC2CC1C3)OC(=O)C4=C[NH]C5=C4C=CC=C5",2.035,3,1,3]
["S5327","Meisoindigo","g6","L3900-21","in 10mM DMSO","Others","Apoptosis","Meisoindigo (N-Methylisoindigotin, Methylisoindigotin, Dian III), a derivative of Indigo naturalis, is an active compound of a Chinese anti-leukemia medicine that has been effectively used in the treatment of chronic myelogenous leukemia (CML). In vitro cell line studies have shown that this agent might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).",276.29,"97207-47-1",{"v":55,"d":"55.00"},199.07,"<1","N/A","http://selleckchem.com/products/meisoindigo.html","C17H12N2O2","free base","N-Methylisoindigotin, Methylisoindigotin, Dian III","CN1C(=O)/C(C2=C1C=CC=C2)=C3/C(=O)NC4=CC=CC=C34",1.851,2,1,0]
["S5350","Cefpodoxime proxetil","h6","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity.",{"v":557.6,"d":"557.60"},"87239-81-4",{"v":100,"d":"100.00"},179.34,"<1","N/A","http://selleckchem.com/products/cefpodoxime-proxetil.html","C21H27N5O9S2","free base","N/A","COCC1=C(N2C(SC1)C(NC(=O)C(=N/OC)\\C3=CSC(=N3)N)C2=O)C(=O)OC(C)OC(=O)OC(C)C",0.715,11,2,13]
["S5351","Cefmetazole sodium","a7","L3900-21","in 10mM DMSO","Antibiotics","Microbiology","Cefmetazole sodium is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms.",493.52,"56796-39-5",{"v":98,"d":"98.00"},198.57,{"v":98,"d":"98.00"},198.57,"https://www.selleckchem.com/products/cefmetazole-sodium.html","C15H16N7O5S3.Na","sodium salt","Sodium cefmetazole","[Na+].COC1(NC(=O)CSCC#N)C2SCC(=C(N2C1=O)C([O-])=O)CSC3=NN=N[N]3C",-2.179,6,1,9]
["S5357","Safinamide","b7","L3900-21","in 10mM DMSO","MAO","Metabolism","Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible <v>monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.",302.34,"133865-89-1",{"v":60,"d":"60.00"},198.45,{"v":-1,"d":"-1.00"},-3.31,"http://selleckchem.com/products/safinamide.html","C17H19FN2O2","free base","EMD-1195686, PNU-15774E","CC(NCC1=CC=C(OCC2=CC=CC(=C2)F)C=C1)C(N)=O",2.478,2,2,7]
["S5358","Regadenoson","c7","L3900-21","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Regadenoson (CVT-3146, Lexiscan) is a selective A2A adenosine receptor agonist with coronary vasodilating activity.",390.35,"313348-27-5",{"v":56,"d":"56.00"},143.46,"<1","N/A","http://selleckchem.com/products/regadenoson.html","C15H18N8O5","free base","CVT-3146, Lexiscan","CNC(=O)C1=C[N](N=C1)C2=NC3=C(N=C[N]3C4OC(CO)C(O)C4O)C(=N2)N",-1.925,6,5,4]
["S5359","Butoconazole","d7","L3900-21","in 10mM DMSO","Fungal","Microbiology","Butoconazole is an imidazole antifungal used in gynecology.",411.78,"64872-76-0",{"v":82,"d":"82.00"},199.14,"N/A","N/A","http://selleckchem.com/products/butoconazole.html","C19H17Cl3N2S","free base","N/A","ClC1=CC=C(CCC(C[N]2C=CN=C2)SC3=C(Cl)C=CC=C3Cl)C=C1",6.496,1,0,7]
["S5363","Pikamilone","e7","L3900-21","in 10mM DMSO","Others","Others","Pikamilone is a drug having a central (vegetotropic and vascular) and peripheral (vasodilating) mechanisms of action.",208.21,"34562-97-5",{"v":33,"d":"33.00"},158.49,"N/A","N/A","http://selleckchem.com/products/pikamilone.html","C10H12N2O3","free base","N/A","OC(=O)CCCNC(=O)C1=CN=CC=C1",-0.062,3,1,5]
["S5365","Alogliptin","f7","L3900-21","in 10mM DMSO","DPP","Proteases","Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.",339.39,"850649-61-5",{"v":67,"d":"67.00"},197.41,{"v":18,"d":"18.00"},53.04,"http://selleckchem.com/products/alogliptin.html","C18H21N5O2","Dipeptidyl Peptidase-4","SYR 322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S5368","Lactitol","g7","L3900-21","in 10mM DMSO","Others","Others","Lactitol is a versatile, reduced calorie sweetener derived from natural milk sugar, used in a wide variety of sweetening applications.",344.31,"585-86-4",{"v":68,"d":"68.00"},{"v":197.5,"d":"197.50"},"N/A","N/A","http://selleckchem.com/products/lactitol.html","C12H24O11","free base","N/A","OCC(O)C(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)CO",-4.688,2,9,8]
["S5371","Ajmaline","h7","L3900-21","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.",326.43,"4360-12-7",{"v":65,"d":"65.00"},199.12,{"v":-1,"d":"-1.00"},-3.06,"https://www.selleckchem.com/products/ajmaline.html","C20H26N2O2","free base","Cardiorythmine, Tachmalin","CCC1C(O)N2C3CC1C4C(O)C5(CC24)C3N(C)C6=CC=CC=C56",1.932,0,2,1]
["S5372","Methyl Aminolevulinate Hydrochloride","a8","L3900-21","in 10mM DMSO","Others","Others","Methyl Aminolevulinate (Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride) is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy.",181.62,"79416-27-6",{"v":36,"d":"36.00"},198.22,{"v":-1,"d":"-1.00"},-5.51,"https://www.selleckchem.com/products/methyl-aminolevulinate-hydrochloride.html","C6H12ClNO3","free base","Aminolevulinic acid methyl ester Hydrochloride, Methyl 5-aminolevulinate Hydrochloride","Cl.COC(=O)CCC(=O)CN",-0.613,3,1,5]
["S5373","Pseudolaric Acid B","b8","L3900-21","in 10mM DMSO","Fungal","Microbiology","Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.",432.46,"82508-31-4",{"v":86,"d":"86.00"},198.86,"<1","N/A","https://www.selleckchem.com/products/pseudolaric-acid-b.html","C23H28O8","Diterpenoids","N/A","COC(=O)C1=CCC23CCC(C(C)(OC2=O)\\C=C\\C=C(C)\\C(O)=O)C3(CC1)OC(C)=O",2.793,7,0,7]
["S5385","Imidafenacin","c8","L3900-21","in 10mM DMSO","AChR","GPCR & G Protein","Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).",{"v":319.4,"d":"319.40"},"170105-16-5",{"v":63,"d":"63.00"},197.24,{"v":-1,"d":"-1.00"},-3.13,"https://www.selleckchem.com/products/imidafenacin.html","C20H21N3O","free base","KRP-197, ONO-8025","CC1=NC=C[N]1CCC(C(N)=O)(C2=CC=CC=C2)C3=CC=CC=C3",{"v":2.55,"d":"2.550"},2,1,6]
["S5386","7-Dehydrocholesterol","d8","L3900-21","in 10mM DMSO","Vitamin","Metabolism","7-Dehydrocholesterol (7-DHC, Provitamin D3) is the direct precursor of free cholesterol in the cholesterol biosynthetic pathway in mammalian tissues and also a biosynthetic precursor to vitamin D3.",384.64,"434-16-2",{"v":76,"d":"76.00"},197.59,{"v":-1,"d":"-1.00"},{"v":-2.6,"d":"-2.60"},"https://www.selleckchem.com/products/7-dehydrocholesterol.html","C27H44O","free base","7-DHC, Provitamin D3","CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C",7.126,0,1,5]
["S5387","D-Tagatose","e8","L3900-21","in 10mM DMSO","Others","Others","D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.",180.16,"87-81-0",{"v":36,"d":"36.00"},199.83,{"v":-1,"d":"-1.00"},-5.55,"https://www.selleckchem.com/products/d-tagatose.html","C6H12O6","free base","N/A","OCC(O)C(O)C(O)C(=O)CO",-2.874,1,5,5]
["S5388","Betrixaban","f8","L3900-21","in 10mM DMSO","Factor Xa","Metabolism","Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.",451.91,"330942-05-7",{"v":35,"d":"35.00"},77.45,"<1","N/A","https://www.selleckchem.com/products/betrixaban.html","C23H22ClN5O3","free base","PRT054021","COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC3=CC=C(Cl)C=N3",2.904,4,2,7]
["S5389","Betrixaban maleate","g8","L3900-21","in 10mM DMSO","Factor Xa","Metabolism","Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.",567.98,"936539-80-9",{"v":100,"d":"100.00"},176.06,{"v":1,"d":"1.00"},1.76,"https://www.selleckchem.com/products/betrixaban-maleate.html","C23H22ClN5O3.C4H4O4","maleate","N/A","COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC3=CC=C(Cl)C=N3.OC(=O)\\C=C/C(O)=O",2.943,6,2,9]
["S5392","Mepivacaine","h8","L3900-21","in 10mM DMSO","Others","Others","Mepivacaine (Carbocaine) is a local anesthetic indicated for infiltration, nerve block, and epidural anesthesia.",246.35,"96-88-8",{"v":49,"d":"49.00"},198.91,{"v":-1,"d":"-1.00"},-4.06,"https://www.selleckchem.com/products/mepivacaine.html","C15H22N2O","free base","Carbocaine","CN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",2.981,1,1,2]
["S5394","Tizoxanide","a9","L3900-21","in 10mM DMSO","HCV Protease","Microbiology","Tizoxanide (Desacetyl-nitazoxanide), a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C.",265.25,"173903-47-4",{"v":27,"d":"27.00"},101.79,"<1","N/A","http://selleckchem.com/products/tizoxanide.html","C10H7N3O4S","free base","Desacetyl-nitazoxanide","OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.388,2,2,3]
["S5397","Chlorhexidine","b9","L3900-21","in 10mM DMSO","Anti-infection","Microbiology","Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.",505.45,"55-56-1",{"v":100,"d":"100.00"},197.84,{"v":-1,"d":"-1.00"},-1.98,"https://www.selleckchem.com/products/chlorhexidine.html","C22H30Cl2N10","free base","N/A","ClC1=CC=C(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC2=CC=C(Cl)C=C2)C=C1",4.373,0,6,17]
["S5398","Nefazodone hydrochloride","c9","L3900-21","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Nefazodone hydrochloride (BMY-13754-1) is the hydrochloride salt form of nefazodone, which is an atypical antidepressant showing antagonistic activity on serotonin reuptake.",506.47,"82752-99-6",{"v":22,"d":"22.00"},43.44,{"v":-1,"d":"-1.00"},-1.97,"https://www.selleckchem.com/products/nefazodone-hydrochloride.html","C25H33Cl2N5O2","free base","BMY-13754-1","Cl.CCC1=NN(CCCN2CCN(CC2)C3=CC(=CC=C3)Cl)C(=O)N1CCOC4=CC=CC=C4",4.797,3,0,10]
["S5399","Chlorprothixene hydrochloride","d9","L3900-21","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Chlorprothixene HCl (Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193) is the  hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.",352.32,"6469-93-8",{"v":70,"d":"70.00"},198.68,{"v":-1,"d":"-1.00"},-2.84,"https://www.selleckchem.com/products/chlorprothixene-hydrochloride.html","C18H19Cl2NS","free base","Minithixen hydrochloride, Truxal hydrochloride, NSC 169899, NSC 56379, NSC 78193","Cl.CN(C)CC\\C=C/1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",5.505,0,0,3]
["S5401","Tegaserod Maleate","e9","L3900-21","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tegaserod Maleate(HTF-919) is a hydrogen maleate salt form of tegaserod, which is a 5-HT4 receptor partial agonist and binds with high affinity to 5-HT4 receptors. It has limited affinity for 5-HT1 receptors and no appreciable affinity for other 5-HT receptors, muscarinic, adrenergic, dopaminergic or opiate receptors.",417.46,"189188-57-6",{"v":83,"d":"83.00"},198.82,"<1","N/A","http://selleckchem.com/products/tegaserod-maleate.html","C16H23N5O.C4H4O4","maleate","HTF-919","CCCCCNC(=N)N/N=C/C1=C[NH]C2=C1C=C(OC)C=C2.OC(=O)\\C=C/C(O)=O",{"v":3.17,"d":"3.170"},4,3,11]
["S5402","Dasabuvir (ABT-333)","f9","L3900-21","in 10mM DMSO","HCV Protease","Proteases","Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.",493.57,"1132935-63-7",{"v":98,"d":"98.00"},198.55,"<1","N/A","http://selleckchem.com/products/dasabuvir-abt-333.html","C26H27N3O5S","free base","N/A","COC1=C(C=C(C=C1C2=CC3=CC=C(N[S](C)(=O)=O)C=C3C=C2)N4C=CC(=O)NC4=O)C(C)(C)C",3.492,5,2,6]
["S5403","Ombitasvir (ABT-267)","g9","L3900-21","in 10mM DMSO","HCV Protease","Proteases","Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.",894.11,"1258226-87-7",{"v":100,"d":"100.00"},111.84,"N/A","N/A","http://selleckchem.com/products/ombitasvir-abt-267.html","C50H67N7O8","free base","N/A","COC(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC2=CC=C(C=C2)C3CCC(N3C4=CC=C(C=C4)C(C)(C)C)C5=CC=C(NC(=O)C6CCCN6C(=O)C(NC(=O)OC)C(C)C)C=C5",7.103,8,4,16]
["S5404","Paritaprevir (ABT-450)","h9","L3900-21","in 10mM DMSO","HCV Protease","Proteases","Paritaprevir (ABT-450) is a nonstructural (NS) protein 3/4A protease inhibitor.",765.88,"1216941-48-8",{"v":100,"d":"100.00"},130.57,"N/A","N/A","http://selleckchem.com/products/paritaprevir-abt-450.html","C40H43N7O7S","free base","N/A","CC1=NC=C(N=C1)C(=O)NC2CCCCC\\C=C/C3CC3(NC(=O)C4CC(CN4C2=O)OC5=NC6=C(C=CC=C6)C7=C5C=CC=C7)C(=O)N[S](=O)(=O)C8CC8",3.104,10,3,7]
["S5406","Sultamicillin Tosylate","a10","L3900-21","in 10mM DMSO","Bacterial","Microbiology","Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.",766.86,"83105-70-8",{"v":100,"d":"100.00"},{"v":130.4,"d":"130.40"},{"v":9,"d":"9.00"},11.74,"http://www.selleckchem.com/products/sultamicillin-tosylate.html","C32H38N4O12S3","Tosylate","N/A","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2(C)SC3CC(=O)N3C2C(=O)OCOC(=O)C4N5C(C(NC(=O)C(N)C6=CC=CC=C6)C5=O)[S](=O)(=O)C4(C)C",1.413,9,2,10]
["S5410","Chloramphenicol sodium succinate","b10","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity.",445.18,"982-57-0",{"v":89,"d":"89.00"},199.92,"N/A","N/A","http://selleckchem.com/products/chloramphenicol-sodium-succinate.html","C15H15Cl2N2O8.Na","sodium salt","N/A","[Na+].OC(C(COC(=O)CCC([O-])=O)NC(=O)C(Cl)Cl)C1=CC=C(C=C1)[N+]([O-])=O",-0.225,3,2,11]
["S5411","Sultamicillin","c10","L3900-21","in 10mM DMSO","β-lactamase","Microbiology","Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester.",594.66,"76497-13-7",{"v":100,"d":"100.00"},168.16,{"v":-1,"d":"-1.00"},-1.68,"http://selleckchem.com/products/sultamicillin.html","C25H30N4O9S2","free base","N/A","CC1(C)SC2C(NC(=O)C(N)C3=CC=CC=C3)C(=O)N2C1C(=O)OCOC(=O)C4N5C(CC5=O)[S](=O)(=O)C4(C)C",-0.237,9,2,9]
["S5413","Ertugliflozin","d10","L3900-21","in 10mM DMSO","SGLT","GPCR & G Protein","Ertugliflozin (MK-8835, PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1.",436.88,"1210344-57-2",{"v":87,"d":"87.00"},199.14,{"v":87,"d":"87.00"},199.14,"https://www.selleckchem.com/products/ertugliflozin.html","C22H25ClO7","free base","MK-8835, PF-04971729","CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)C34OCC(CO)(O3)C(O)C(O)C4O)C=C1",2.103,3,4,6]
["S5414","Diflucortolone valerate","e10","L3900-21","in 10mM DMSO","Others","Others","Diflucortolone valerate (Afusona, Diflucortolone 21-valerate) is a potent corticosteroid esterified with valeric acid. It helps reduce swelling, itching, and redness.",478.57,"59198-70-8",{"v":95,"d":"95.00"},198.51,{"v":-1,"d":"-1.00"},-2.09,"http://selleckchem.com/products/diflucortolone-valerate.html","C27H36F2O5","free base","Afusona, Diflucortolone 21-valerate","CCCCC(=O)OCC(=O)C1C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C",4.172,4,1,7]
["S5416","Metyrapone","f10","L3900-21","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.",226.27,"54-36-4",{"v":46,"d":"46.00"},203.29,{"v":-1,"d":"-1.00"},-4.42,"https://www.selleckchem.com/products/metyrapone.html","C14H14N2O","free base","NSC-25265, SU-4885","CC(C)(C1=CC=CN=C1)C(=O)C2=CC=CN=C2",1.847,3,0,3]
["S5418","Parecoxib Sodium","g10","L3900-21","in 10mM DMSO","COX","Immunology & Inflammation","Parecoxib Sodium (SC-69124) is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).",{"v":392.4,"d":"392.40"},"198470-85-8",{"v":78,"d":"78.00"},198.77,{"v":-1,"d":"-1.00"},-2.55,"https://www.selleckchem.com/products/parecoxib-sodium.html","C19H17N2NaO4S","free base","SC-69124 Sodium","CCC(=O)N([Na])[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",{"v":3.36,"d":"3.360"},5,0,5]
["S5420","Clindamycin alcoholate","h10","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Clindamycin alcoholate is a crystallizable compound of Clindamycin with alcohol. Clindamycin is a semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.",479.46,"58207-19-5",{"v":95,"d":"95.00"},198.14,"N/A","N/A","http://selleckchem.com/products/clindamycin-alcoholate.html","C18H33ClN2O5S.HCl.H2O","hydrochloride, monohydrate","N/A","O.Cl.CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O)C(O)C2O",1.451,2,4,7]
["S5426","Bromopyruvic acid","a11","L3900-21","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.",166.96,"1113-59-3",{"v":33,"d":"33.00"},197.65,"N/A","N/A","http://selleckchem.com/products/bromopyruvic-acid.html","C3H3BrO3","free base","3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP","OC(=O)C(=O)CBr",0.348,2,0,2]
["S5430","Metoprolol","b11","L3900-21","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Metoprolol is a cardioselective β1-adrenergic blocking agent with log Kd values of −7.26±0.07, −6.89±0.09, −5.16±0.12 for β1, β2, and β3 adrenoceptors, respectively. It is used for acute myocardial infarction, heart failure, angina pectoris and mild to moderate hypertension.",267.36,"51384-51-1",{"v":53,"d":"53.00"},198.23,"N/A","N/A","http://selleckchem.com/products/metoprolol.html","C15H25NO3","free base","N/A","COCCC1=CC=C(OCC(O)CNC(C)C)C=C1",1.757,2,2,9]
["S5435","Quinacrine Dihydrochloride Dihydrate","c11","L3900-21","in 10mM DMSO","Others","Others","Quinacrine (Mepacrine) is a dye of the acridine family that has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug.",508.91,"6151-30-0",{"v":10,"d":"10.00"},19.65,"N/A","N/A","http://selleckchem.com/products/quinacrine-dihydrochloride-dihydrate.html","C23H30ClN3O.2HCl.2H2O","dihydrochloride, dihydrate","Mepacrine Dihydrochloride Dihydrate","O.O.Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",6.015,2,1,9]
["S5440","Berberine Sulfate","d11","L3900-21","in 10mM DMSO","Bacterial","Microbiology","Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.",433.43,"633-66-9",{"v":20,"d":"20.00"},46.14,"N/A","N/A","http://selleckchem.com/products/berberine-sulfate.html","C20H18NO4.HO4S","sulfate","Umbellatine Sulfate","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4.O[S]([O-])(=O)=O",1.111,4,0,2]
["S5451","Ferulic acid methyl ester","e11","L3900-21","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid,  which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.",208.21,"2309-07-1",{"v":41,"d":"41.00"},196.92,{"v":41,"d":"41.00"},196.92,"http://selleckchem.com/products/ferulic-acid-methylester.html","C11H12O4","free base","Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate","COC(=O)\\C=C\\C1=CC=C(O)C(=C1)OC",1.894,3,1,4]
["S5458","Verbascoside","f11","L3900-21","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.",624.59,"61276-17-3",{"v":100,"d":"100.00"},160.11,{"v":100,"d":"100.00"},160.11,"http://selleckchem.com/products/verbascoside.html","C29H36O15","free base","Acteoside, Kusaginin","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(CO)C2OC(=O)\\C=C\\C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",0.484,6,9,11]
["S5473","Pivmecillinam hydrochloride","g11","L3900-21","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Pivmecillinam is a β-lactam antibiotic and a prodrug of mecillinam. It has selective activity against Gram-negative bacteria and is used primarily in the treatment of lower urinary tract infections.",476.03,"32887-03-9",{"v":95,"d":"95.00"},199.57,{"v":95,"d":"95.00"},199.57,"http://selleckchem.com/products/pivmecillinam-hydrochloride.html","C21H33N3O5S.HCl","hydrochloride","N/A","Cl.CC(C)(C)C(=O)OCOC(=O)C1N2C(SC1(C)C)C(N=CN3CCCCCC3)C2=O",3.161,6,0,8]
["S5476","Rolapitant","h11","L3900-21","in 10mM DMSO","Neurokinin Receptor","Neuronal Signaling","Rolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.",500.48,"552292-08-7",{"v":100,"d":"100.00"},199.81,"N/A","N/A","https://www.selleckchem.com/products/rolapitant.html","C25H26F6N2O2","NK1 receptor antagonists","SCH-619734","CC(OCC1(CCC2(CCC(=O)N2)CN1)C3=CC=CC=C3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",4.761,2,2,7]
["S5477","Gefarnate","a2","L3900-22","in 10mM DMSO","Others","Others","Gefarnate (Geranyl farnesylacetate) is a synthetic compound used for the treatment of gastric ulcers.",400.64,"51-77-4","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/gefarnate.html","C27H44O2","free base","Geranyl farnesylacetate","CC(C)=CCC/C(C)=C/CC\\C(C)=C\\CCC(=O)OC\\C=C(C)\\CCC=C(C)C",9.003,2,0,15]
["S5478","Dantrolene sodium","b2","L3900-22","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.",336.23,"14663-23-1",{"v":67,"d":"67.00"},199.27,{"v":-1,"d":"-1.00"},-2.97,"https://www.selleckchem.com/products/s5478-dantrolene-sodium.html","C14H9N4NaO5","free base","F 440","[Na+].[O-]C1=NC(=O)CN1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+]([O-])=O",1.769,4,0,4]
["S5480","Clidinium Bromide","c2","L3900-22","in 10mM DMSO","AChR","Neuronal Signaling","Clidinium Bromide(Ro 2-3773) is an anticholinergic drug.",432.35,"3485-62-9",{"v":86,"d":"86.00"},198.91,"N/A","N/A","http://selleckchem.com/products/clidinium-bromide.html","C22H26NO3.Br","bromide","Ro 2-3773","[Br-].C[N+]12CCC(CC1)C(C2)OC(=O)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",-0.622,2,0,5]
["S5481","Molindone hydrochloride","d2","L3900-22","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.",312.83,"15622-65-8",{"v":9,"d":"9.00"},28.77,"N/A","N/A","http://selleckchem.com/products/molindone-hydrochloride.html","C16H24N2O2.HCl","hydrochloride","N/A","Cl.CCC1=C(C)[NH]C2=C1C(=O)C(CC2)CN3CCOCC3",2.522,2,1,3]
["S5482","Prilocaine hydrochloride","e2","L3900-22","in 10mM DMSO","Others","Others","Prilocaine hydrochloride is the hydrochloride salt form of prilocaine, which is a local anesthetic.",256.77,"1786-81-8",{"v":51,"d":"51.00"},198.62,"N/A","N/A","https://www.selleckchem.com/products/prilocaine-hydrochloride.html","C13H20N2O.HCl","hydrochloride","N/A","Cl.CCCNC(C)C(=O)NC1=CC=CC=C1C",2.645,1,2,5]
["S5484","Rimantadine Hydrochloride","f2","L3900-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.",215.76,"1501-84-4",{"v":43,"d":"43.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","http://selleckchem.com/products/rimantadine-hydrochloride.html","C12H21N.HCl","hydrochloride","N/A","Cl.CC(N)[C]12C[CH]3C[CH]([CH2]C([CH2]3)C1)C2",2.586,0,1,1]
["S5485","Desipramine Hydrochloride","g2","L3900-22","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.",302.84,"58-28-6",{"v":60,"d":"60.00"},198.12,"N/A","N/A","http://selleckchem.com/products/desipramine-hydrochloride.html","C18H22N2.HCl","hydrochloride","Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901","Cl.CNCCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.234,0,1,4]
["S5486","Fluorometholone","h2","L3900-22","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.",376.46,"426-13-1",{"v":75,"d":"75.00"},199.22,"<1","N/A","http://selleckchem.com/products/fluorometholone.html","C22H29FO4","free base","Oxylone","CC1CC2C3CCC(O)(C(C)=O)C3(C)CC(O)C2(F)C4(C)C=CC(=O)C=C14",2.312,2,1,1]
["S5487","Cefoperazone sodium","a3","L3900-22","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefoperazone Sodium(CP 52640-2) is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity.",667.65,"62893-20-3",{"v":100,"d":"100.00"},149.78,{"v":-1,"d":"-1.00"},{"v":-1.5,"d":"-1.50"},"https://www.selleckchem.com/products/cefoperazone-sodium.html","C25H26N9NaO8S2","free base","CP 52640-2","[Na+].CCN1CCN(C(=O)NC(C(=O)NC2C3SCC(=C(N3C2=O)C([O-])=O)CSC4=NN=N[N]4C)C5=CC=C(O)C=C5)C(=O)C1=O",-2.266,8,3,9]
["S5488","Fluorescein","b3","L3900-22","in 10mM DMSO","Dyes","Others","Fluorescein (Solvent Yellow 94, Resorcinolphthalein, Yellow fluorescein) is a manufactured organic compound and dye.",332.31,"2321-07-5",{"v":67,"d":"67.00"},201.62,{"v":-1,"d":"-1.00"},-3.01,"https://www.selleckchem.com/products/fluorescein.html","C20H12O5","free base","Solvent Yellow 94, Resorcinolphthalein, Yellow fluorescein","OC1=CC2=C(C=C1)C3(OC(=O)C4=C3C=CC=C4)C5=C(O2)C=C(O)C=C5",3.737,3,2,0]
["S5490","Disopyramide","c3","L3900-22","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.",339.47,"3737-09-5",{"v":67,"d":"67.00"},197.37,"N/A","N/A","http://selleckchem.com/products/disopyramide.html","C21H29N3O","Antiarrhythmic agent","N/A","CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C2=NC=CC=C2)C(C)C",3.417,2,1,8]
["S5491","Lomefloxacin","d3","L3900-22","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Lomefloxacin(SC47111A) is a fluoroquinolone antibiotic used to treat bacterial infections.",351.35,"98079-51-7",{"v":7,"d":"7.00"},19.92,{"v":-1,"d":"-1.00"},-2.85,"https://www.selleckchem.com/products/lomefloxacin.html","C17H19F2N3O3","free base","SC47111A","CCN1C=C(C(O)=O)C(=O)C2=C1C(=C(N3CCNC(C)C3)C(=C2)F)F",-0.828,2,1,3]
["S5492","Econazole","e3","L3900-22","in 10mM DMSO","Bacterial","Microbiology","Econazole is a broad spectrum antimycotic with some action against Gram positive bacteria.",381.68,"27220-47-9",{"v":76,"d":"76.00"},199.12,"N/A","N/A","http://selleckchem.com/products/econazole.html","C18H15Cl3N2O","free base","N/A","ClC1=CC=C(COC(C[N]2C=CN=C2)C3=C(Cl)C=C(Cl)C=C3)C=C1",4.981,2,0,6]
["S5493","Atropine sulfate","f3","L3900-22","in 10mM DMSO","AChR","Neuronal Signaling","Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.",676.82,"55-48-1",{"v":18,"d":"18.00"},26.59,"N/A","N/A","https://www.selleckchem.com/products/atropine-sulfate.html","C34H46N2O6.H2SO4","sulfate","Sulfatropinol, Atropette, Tropintran","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN4C5CCC4CC(C5)OC(=O)C(CO)C6=CC=CC=C6.O[S](O)(=O)=O",2.835,4,2,10]
["S5494","Salbutamol","g3","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.",239.31,"18559-94-9",{"v":47,"d":"47.00"},{"v":196.4,"d":"196.40"},"N/A","N/A","https://www.selleckchem.com/products/salbutamol.html","C13H21NO3","free base","Albuterol","CC(C)(C)NCC(O)C1=CC=C(O)C(=C1)CO",0.941,0,4,5]
["S5498","Betahistine mesylate","h3","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.",328.41,"54856-23-4",{"v":65,"d":"65.00"},197.92,"N/A","N/A","http://selleckchem.com/products/betahistine-mesylate.html","C8H12N2.2CH4O3S","dimethanesulfonate","N/A","CNCCC1=CC=CC=N1.C[S](O)(=O)=O.C[S](O)(=O)=O",-0.148,1,1,3]
["S5500","Amodiaquine hydrochloride","a4","L3900-22","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.",428.78,"69-44-3",{"v":56,"d":"56.00"},{"v":130.6,"d":"130.60"},"N/A","N/A","https://www.selleckchem.com/products/amodiaquine-hydrochloride.html","C20H22ClN3O.2HCl","dihydrochloride","N/A","Cl.Cl.CCN(CC)CC1=CC(=CC=C1O)NC2=C3C=CC(=CC3=NC=C2)Cl",5.523,1,2,6]
["S5501","Hydrocortisone acetate","b4","L3900-22","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Hydrocortisone Acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.",{"v":404.5,"d":"404.50"},"50-03-3",{"v":80,"d":"80.00"},197.78,"N/A","N/A","https://www.selleckchem.com/products/hydrocortisone-acetate.html","C23H32O6","free base","Cortisol 21-acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C",1.662,4,1,4]
["S5502","Ilaprazole sodium","c4","L3900-22","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.",388.42,"172152-50-0",{"v":78,"d":"78.00"},200.81,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/iiaprazole-sodium.html","C19H17N4NaO2S","Sodium Salt","IY-81149 sodium","COC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=C(C=CC(=C3)[N]4C=CC=C4)[N]2[Na]",3.414,4,0,5]
["S5503","O-Acetyl-L-carnitine hydrochloride","d4","L3900-22","in 10mM DMSO","Others","Others","O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.",{"v":239.7,"d":"239.70"},"5080-50-2",{"v":48,"d":"48.00"},200.25,{"v":-1,"d":"-1.00"},-4.17,"https://www.selleckchem.com/products/o-acetyl-l-carnitine-hydrochloride.html","C9H18ClNO4","Salt","Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine","[Cl-].CC(=O)OC(CC(O)=O)C[N+](C)(C)C",-4.111,3,0,6]
["S5504","Ropivacaine","e4","L3900-22","in 10mM DMSO","Others","Others","Ropivacaine is a member of the amino amide class of local anesthetics.",{"v":274.4,"d":"274.40"},"84057-95-4",{"v":23,"d":"23.00"},83.82,"<1","N/A","https://www.selleckchem.com/products/ropivacaine.html","C17H26N2O","Amide local anesthetics","N/A","CCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",3.853,1,1,4]
["S5507","Trimebutine maleate","f4","L3900-22","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.",503.54,"34140-59-5",{"v":100,"d":"100.00"},198.59,{"v":-1,"d":"-1.00"},-1.99,"https://www.selleckchem.com/products/trimebutine-maleate.html","C26H33NO9","Maleate salt","3, 4, 5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester Maleate Salt;","CCC(COC(=O)C1=CC(=C(OC)C(=C1)OC)OC)(N(C)C)C2=CC=CC=C2.OC(=O)\\C=C/C(O)=O",{"v":1.12,"d":"1.120"},7,0,12]
["S5514","Lanthanum(III) chloride heptahydrate","g4","L3900-22","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.",371.37,"10025-84-0",{"v":50,"d":"50.00"},134.64,"N/A","N/A","http://selleckchem.com/products/lanthanum-iii-chloride-heptahydrate.html","Cl3La.7H2O","salt","N/A","O.O.O.O.O.O.O.Cl[La](Cl)Cl",0.006,0,0,0]
["S5527","Salmeterol","h4","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).",415.57,"89365-50-4",{"v":83,"d":"83.00"},199.73,"<1","N/A","http://selleckchem.com/products/salmeterol.html","C25H37NO4","free base","Astmerole, GR-33343X, SN408D","OCC1=C(O)C=CC(=C1)C(O)CNCCCCCCOCCCCC2=CC=CC=C2",4.251,1,4,16]
["S5531","Doripenem","a5","L3900-22","in 10mM DMSO","Antibiotics","Microbiology","Doripenem(S 4661) is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.",{"v":420.5,"d":"420.50"},"148016-81-3",{"v":60,"d":"60.00"},142.69,{"v":-1,"d":"-1.00"},-2.38,"https://www.selleckchem.com/products/doripenem.html","C15H24N4O6S2","free base","S 4661","CC(O)C1C2C(C)C(=C(N2C1=O)C(O)=O)SC3CNC(CN[S](N)(=O)=O)C3",-5.339,4,4,7]
["S5532","Erythromycin estolate","b5","L3900-22","in 10mM DMSO","Bacterial","Microbiology","Erythromycin (Lubomycine B), a naturally occurring macrolide, is derived from Streptomyces erythrus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.",1056.39,"3521-62-8",{"v":100,"d":"100.00"},94.66,{"v":-1,"d":"-1.00"},-0.95,"https://www.selleckchem.com/products/erythromycin-estolate.html","C52H97NO18S","free base","Lubomycine B","CCCCCCCCCCCCO[S](O)(=O)=O.CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3OC(=O)CC)N(C)C)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O",7.248,11,2,22]
["S5535","Moxifloxacin","c5","L3900-22","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro.",401.43,"151096-09-2",{"v":24,"d":"24.00"},59.79,{"v":-1,"d":"-1.00"},-2.49,"https://www.selleckchem.com/products/moxifloxacin.html","C21H24FN3O4","free base","BAY12-8039","COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CC4CCCNC4C3)F)C5CC5",-0.702,3,1,4]
["S5537","Tizanidine","d5","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.",253.71,"51322-75-9",{"v":50,"d":"50.00"},197.07,{"v":15,"d":"15.00"},59.12,"http://selleckchem.com/products/tizanidine.html","C9H8ClN5S","α2-adrenergic agonists","N/A","ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1",1.817,3,2,2]
["S5538","Tropisetron","e5","L3900-22","in 10mM DMSO","5-HT Receptor,AChR","Neuronal Signaling","Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.",284.35,"89565-68-4",{"v":10,"d":"10.00"},35.17,{"v":56,"d":"56.00"},196.94,"http://selleckchem.com/products/tropisetron.html","C17H20N2O2","free base","ICS 205-930","CN1C2CCC1CC(C2)OC(=O)C3=C[NH]C4=C3C=CC=C4",2.608,2,1,3]
["S5539","Olprinone","f5","L3900-22","in 10mM DMSO","PDE","Metabolism","Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively.",250.26,"106730-54-5",{"v":50,"d":"50.00"},{"v":199.8,"d":"199.80"},{"v":-1,"d":"-1.00"},{"v":-4,"d":"-4.00"},"https://www.selleckchem.com/products/olprinone.html","C14H10N4O","free base","N/A","CC1=C(C=C(C#N)C(=O)N1)C2=C[N]3C=CN=C3C=C2",0.248,2,1,1]
["S5540","Landiolol hydrochloride","g5","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Landiolol hydrochloride (ONO-1101) is the hydrochloride salt form of Landiolol, which is an ultra-short-acting β1 selective adrenoceptor antagonist.",546.05,"144481-98-1",{"v":100,"d":"100.00"},183.13,{"v":100,"d":"100.00"},183.13,"https://www.selleckchem.com/products/landiolol-hydrochloride.html","C25H39N3O8.HCl","hydrochloride","ONO-1101 hydrochloride","Cl.CC1(C)OCC(COC(=O)CCC2=CC=C(OCC(O)CNCCNC(=O)N3CCOCC3)C=C2)O1",{"v":0.4,"d":"0.400"},7,3,14]
["S5546","Sulfacetamide","h5","L3900-22","in 10mM DMSO","Bacterial","Microbiology","Sulfacetamide (Acetosulfamine) is a synthetic sulfanylacetamide derivative with bacteriostatic activity. It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.",214.24,"144-80-9",{"v":43,"d":"43.00"},200.71,{"v":-1,"d":"-1.00"},-4.67,"https://www.selleckchem.com/products/sulfacetamide.html","C8H10N2O3S","free base","Acetosulfamine","CC(=O)N[S](=O)(=O)C1=CC=C(N)C=C1",-0.222,3,2,2]
["S5552","Amenamevir","a6","L3900-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.",482.55,"841301-32-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/amenamevir.html","C24H26N4O5S","free base","ASP2151","CC1=C(N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CC[S](=O)(=O)CC4)C(=CC=C1)C",{"v":2.24,"d":"2.240"},7,1,6]
["S5561","Ethacrynic Acid","b6","L3900-22","in 10mM DMSO","Others","NF-κB","Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.",303.14,"58-54-8",{"v":61,"d":"61.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ethacrynic-acid.html","C13H12Cl2O4","Free Base","N/A","CCC(=C)C(=O)C1=C(Cl)C(=C(OCC(O)=O)C=C1)Cl",3.963,3,0,6]
["S5563","Thioridazine hydrochloride","c6","L3900-22","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Thioridazine (Aldazine, Mellaril) is a potent antianxiety and antipsychotic agent.",407.04,"130-61-0",{"v":81,"d":"81.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/thioridazine-hydrochloride.html","C21H26N2S2.HCl","hydrochloride","Aldazine, Mellaril","Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC4CCCCN4C)C=C1",5.945,0,0,4]
["S5566","Dapagliflozin propanediol monohydrate","d6","L3900-22","in 10mM DMSO","SGLT","GPCR & G Protein","Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.",502.98,"960404-48-2",{"v":100,"d":"100.00"},198.82,"<1","N/A","http://selleckchem.com/products/dapagliflozin-propanediol-monohydrate.html","C21H25ClO6.C3H8O2.H2O","monohydrate","N/A","O.CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)C3OC(CO)C(O)C(O)C3O)C=C1.CC(O)CO",1.682,2,6,7]
["S5568","Tocofersolan","e6","L3900-22","in 10mM DMSO","Vitamin","Metabolism","Tocofersolan (Tocophersolan) is a synthetic water-soluble version of vitamin E that is used in treatment of vitamin E deficiency.",574.83,"9002-96-4",{"v":100,"d":"100.00"},173.96,{"v":-1,"d":"-1.00"},-1.74,"https://www.selleckchem.com/products/tocofersolan.html","(C2H4O)nC33H54O5","free base","Tocophersolan","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)OC(=O)CCC(=O)OCCO",10.716,5,1,20]
["S5570","Arachidic acid","f6","L3900-22","in 10mM DMSO","Others","Others","Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants.",312.53,"506-30-9",{"v":62,"d":"62.00"},198.38,"N/A","N/A","http://selleckchem.com/products/arachidic-acid.html","C20H40O2","free base","eicosanoic acid, Icosanoic Acid","CCCCCCCCCCCCCCCCCCCC(O)=O",8.217,1,0,18]
["S5581","Olmesartan","g6","L3900-22","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Olmesartan (RNH-6270) is an an angiotensin 2 receptor antagonist with antihypertensive activity.",{"v":446.5,"d":"446.50"},"144689-24-7",{"v":89,"d":"89.00"},199.33,{"v":-1,"d":"-1.00"},-2.24,"https://www.selleckchem.com/products/olmesartan.html","C24H26N6O3","free base","RNH-6270","CCCC1=NC(=C([N]1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=N[NH]4)C(O)=O)C(C)(C)O",3.766,5,1,8]
["S5582","Cytarabine hydrochloride","h6","L3900-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.",279.68,"69-74-9",{"v":55,"d":"55.00"},196.65,"N/A","N/A","http://selleckchem.com/products/cytarabine-hydrochloride.html","C9H13N3O5.HCl","hydrochloride","N/A","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.014,3,4,2]
["S5592","Vitamin A","a7","L3900-22","in 10mM DMSO","Vitamin","Metabolism","Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs.",286.45,"68-26-8",{"v":57,"d":"57.00"},198.99,{"v":-1,"d":"-1.00"},-3.49,"https://www.selleckchem.com/products/vitamin-a.html","C20H30O","free base","Retinol","CC(=C/CO)\\C=C\\C=C(C)\\C=C\\C1=C(C)CCCC1(C)C",5.316,0,1,5]
["S5616","4-Methylcatechol","b7","L3900-22","in 10mM DMSO","Others","Others","4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.",124.14,"452-86-8",{"v":24,"d":"24.00"},193.33,{"v":-1,"d":"-1.00"},-8.06,"https://www.selleckchem.com/products/4-methylcatechol.html","C7H8O2","free base","P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol","CC1=CC(=C(O)C=C1)O",1.832,0,2,0]
["S5618","Hippuric acid","c7","L3900-22","in 10mM DMSO","Others","Others","Hippuric Acid (2-Benzamidoacetic acid, Benzoylglycine) is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine as a metabolite of aromatic compounds from food.",179.17,"495-69-2",{"v":35,"d":"35.00"},195.35,"N/A","N/A","http://selleckchem.com/products/hippuric-acid.html","C9H9NO3","free base","2-Benzamidoacetic acid, Benzoylglycine","OC(=O)CNC(=O)C1=CC=CC=C1",0.519,2,1,3]
["S5619","Betahistine","d7","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Betahistine is an antivertigo drug that primarily acts as a histamine H1 agonist.",136.19,"5638-76-6","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/betahistine.html","C8H12N2","free base","N/A","CNCCC1=NC=CC=C1",{"v":0.68,"d":"0.680"},1,1,3]
["S5620","NSI-189","e7","L3900-22","in 10mM DMSO","Others","Neuronal Signaling","NSI-189, a small molecule with enhanced neurogenic activity, is a potential antidepressant for the treatment of major depressive disorder (MDD), cognitive impairment and neurodegeneration.",{"v":366.5,"d":"366.50"},"1270138-40-3",{"v":73,"d":"73.00"},199.18,"<1","N/A","http://selleckchem.com/products/nsi-189.html","C22H30N4O","free base","N/A","CC(C)CCNC1=NC=CC=C1C(=O)N2CCN(CC2)CC3=CC=CC=C3",3.562,2,1,7]
["S5621","Cilastatin","f7","L3900-22","in 10mM DMSO","Others","Metabolism","Cilastatin(MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.",358.45,"82009-34-5",{"v":90,"d":"90.00"},251.08,{"v":7,"d":"7.00"},19.53,"http://selleckchem.com/products/cilastatin.html","C16H26N2O5S","free base","MK0791","CC1(C)CC1C(=O)N\\C(=C/CCCCSCC(N)C(O)=O)C(O)=O",-1.459,3,2,11]
["S5623","Bedaquiline","g7","L3900-22","in 10mM DMSO","ATPase","Transmembrane Transporters","Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).",{"v":555.5,"d":"555.50"},"843663-66-1",{"v":12,"d":"12.00"},{"v":21.6,"d":"21.60"},"<1","N/A","https://www.selleckchem.com/products/bedaquiline.html","C32H31BrN2O2","free base","TMC-207, R207910","COC1=NC2=CC=C(Br)C=C2C=C1C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=CC=CC5=CC=CC=C45",6.933,2,0,8]
["S5625","Ammonium lactate","h7","L3900-22","in 10mM DMSO","Bacterial","Microbiology","Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties.",107.11,"515-98-0","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/ammonium-iactate.html","C3H9NO3","free base","Lac-hydrin","[NH4+].CC(O)C([O-])=O",-3.725,0,1,1]
["S5626","Benzalkonium chloride","a8","L3900-22","in 10mM DMSO","Others","Others","Benzalkonium chloride, a detergent and preservative found in health care and household products, is an established irritant.","N/A","63449-41-2, 8001-54-5",{"v":51,"d":"51.00"},{"v":10,"d":"10.00"},"N/A","N/A","https://www.selleckchem.com/products/benzalkonium-chloride.html","C15H26ClNR","free base","N/A","[Cl-].CCCCCC[N+](C)(C)CC1=CC=CC=C1",{"v":0.85,"d":"0.850"},0,0,7]
["S5627","Amsacrine hydrochloride","b8","L3900-22","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.",429.92,"54301-15-4",{"v":85,"d":"85.00"},197.71,"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/amsacrine-hydrochloride.html","C21H20ClN3O3S","free base","m-AMSA, acridinyl anisidide","Cl.COC1=CC(=CC=C1NC2=C3C=CC=CC3=NC4=C2C=CC=C4)N[S](C)(=O)=O",{"v":4.18,"d":"4.180"},4,2,5]
["S5637","Cefotiam Hexetil Hydrochloride","c8","L3900-22","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity.",768.76,"95789-30-3",{"v":100,"d":"100.00"},130.08,{"v":-1,"d":"-1.00"},{"v":-1.3,"d":"-1.30"},"https://www.selleckchem.com/products/cefotiam-hexetil-hydrochloride.html","C27H39Cl2N9O7S3","free base","N/A","Cl.Cl.CC(OC(=O)OC1CCCCC1)OC(=O)C2=C(CSC3C(NC(=O)CC4=CSC(=N4)N)C(=O)N23)CSC5=NN=N[N]5CCN(C)C",2.966,11,2,16]
["S5638","Cefozopran hydrochloride","d8","L3900-22","in 10mM DMSO","Bacterial","Microbiology","Cefozopran Hydrochloride is the hydrochloride salt form of cefozopran, a semi-synthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity.",551.99,"113981-44-5",{"v":100,"d":"100.00"},181.16,{"v":-1,"d":"-1.00"},-1.81,"https://www.selleckchem.com/products/cefozopran-hydrochloride.html","C19H18ClN9O5S2","free base","N/A","Cl.CO/N=C(C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3=C4C=CC=N[N]4C=C3)/C5=NSC(=N5)N",-1.752,7,2,7]
["S5647","Emedastine Difumarate","e8","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Emedastine Difumarate (Rapimine, Emedastine fumarate) is the difumarate salt form of emedastine, a second generation, selective histamine H1 receptor antagonist with anti-allergic activity.",534.56,"87233-62-3",{"v":100,"d":"100.00"},187.07,{"v":100,"d":"100.00"},187.07,"http://selleckchem.com/products/emedastine-difumarate.html","C17H26N4O.2C4H4O4","Difumarate","Rapimine, Emedastine fumarate","CCOCC[N]1C2=C(C=CC=C2)N=C1N3CCCN(C)CC3.OC(=O)\\C=C\\C(O)=O.OC(=O)\\C=C\\C(O)=O",-0.464,6,0,9]
["S5648","Iguratimod","f8","L3900-22","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Iguratimod (T-614) is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.",374.37,"123663-49-0",{"v":50,"d":"50.00"},133.56,"N/A","N/A","http://selleckchem.com/products/iguratimod.html","C17H14N2O6S","free base","T-614","C[S](=O)(=O)NC1=CC2=C(C=C1OC3=CC=CC=C3)C(=O)C(=CO2)NC=O",0.605,6,2,5]
["S5649","Hydroxyzine pamoate","g8","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Hydroxyzine Pamoate is the pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties.",763.27,"10246-75-0",{"v":100,"d":"100.00"},131.01,{"v":-1,"d":"-1.00"},-1.31,"https://www.selleckchem.com/products/hydroxyzine-pamoate.html","C44H43ClN2O8","free base","N/A","OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.OC(=O)C4=C(O)C(=C5C=CC=CC5=C4)CC6=C7C=CC=CC7=CC(=C6O)C(O)=O",1.794,3,3,12]
["S5651","Dexrazoxane","h8","L3900-22","in 10mM DMSO","Others","Others","Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.",268.27,"24584-09-6",{"v":54,"d":"54.00"},201.29,"<1","N/A","http://selleckchem.com/products/dexrazoxane.html","C11H16N4O4","free base","ICRF-187","CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-2.104,4,2,3]
["S5652","Elbasvir","a9","L3900-22","in 10mM DMSO","HCV Protease","Proteases","Elbasvir (MK8742) is an NS5A inhibitor, preventing hepatitis C viral RNA replication and virion assembly. Median EC50 values range from 0.2 to 3600 pmol/L, based on genotype.",882.02,"1370468-36-2",{"v":100,"d":"100.00"},113.38,"<1","N/A","http://selleckchem.com/products/elbasvir.html","C49H55N9O7","free base","MK8742","COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC4=C(C=C3)C5=CC6=C(C=CC(=C6)C7=CN=C([NH]7)C8CCCN8C(=O)C(NC(=O)OC)C(C)C)[N]5C(O4)C9=CC=CC=C9",7.424,9,4,13]
["S5653","Indigo carmine","b9","L3900-22","in 10mM DMSO","Others","Others","Indigo carmine (Indigotine, 5,5′-indigodisulfonic acid sodium salt, Brilliant Indigo) is an indicator at pH 11.5-14, changing from blue to yellow. It has a role as a food colouring and a histological dye.",466.35,"860-22-0",{"v":93,"d":"93.00"},199.42,{"v":-1,"d":"-1.00"},-2.14,"https://www.selleckchem.com/products/indigo-carmine.html","C16H8N2Na2O8S2","free base","Indigotine, 5,5′-indigodisulfonic acid sodium salt, Brilliant Indigo","[Na+].[Na+].[O-][S](=O)(=O)C1=CC2=C(NC(/C2=O)=C\\3NC4=C(C=C(C=C4)[S]([O-])(=O)=O)C3=O)C=C1",-3.717,2,2,2]
["S5654","Indacaterol","c9","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.",392.49,"312753-06-3",{"v":52,"d":"52.00"},132.49,"<1","N/A","http://selleckchem.com/products/indacaterol.html","C24H28N2O3","free base","N/A","CCC1=CC2=C(CC(C2)NCC(O)C3=CC=C(O)C4=C3C=CC(=O)N4)C=C1CC",{"v":3.93,"d":"3.930"},1,4,6]
["S5655","Venlafaxine","d9","L3900-22","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.",{"v":277.4,"d":"277.40"},"93413-69-5",{"v":55,"d":"55.00"},198.27,"<1","N/A","http://selleckchem.com/products/venlafaxine.html","C17H27NO2","Phenethylamine","Wy 45030","COC1=CC=C(C=C1)C(CN(C)C)C2(O)CCCCC2",3.022,1,0,5]
["S5657","Ertapenem sodium","e9","L3900-22","in 10mM DMSO","Antibiotics","Microbiology","Ertapenem Sodium (MK826) is the sodium salt of ertapenem, a long-acting, broad-spectrum antibiotic of β-lactam subclass.",{"v":497.5,"d":"497.50"},"153773-82-1",{"v":100,"d":"100.00"},201.01,{"v":100,"d":"100.00"},201.01,"http://selleckchem.com/products/ertapenem-sodium.html","C22H24N3NaO7S","sodium salt","MK826","[Na+].CC(O)C1C2C(C)C(=C(N2C1=O)C([O-])=O)SC3CNC(C3)C(=O)NC4=CC(=CC=C4)C(O)=O",-4.602,3,3,7]
["S5658","Omeprazole Sodium","f9","L3900-22","in 10mM DMSO","P450 (e.g. CYP17),Proton Pump","Transmembrane Transporters","Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.",{"v":367.4,"d":"367.40"},"95510-70-6",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://www.selleckchem.com/products/omeprazole-sodium.html","C17H18N3NaO3S","Sodium Salt","N/A","COC1=CC2=C(C=C1)[N]([Na])C(=N2)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S5659","Emedastine","g9","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).",302.41,"87233-61-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/emedastine.html","C17H26N4O","free base","N/A","CCOCC[N]1C2=C(C=CC=C2)N=C1N3CCCN(C)CC3",2.492,2,0,5]
["S5662","Ranitidine","h9","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ranitidine(AH-19065) is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.",{"v":314.4,"d":"314.40"},"66357-35-5",{"v":63,"d":"63.00"},200.38,{"v":-1,"d":"-1.00"},-3.18,"https://www.selleckchem.com/products/ranitidine.html","C13H22N4O3S","free base","AH-19065","CNC(/NCCSCC1=CC=C(CN(C)C)O1)=C\\[N+]([O-])=O",1.039,1,2,10]
["S5664","Orphenadrine Hydrochloride","a10","L3900-22","in 10mM DMSO","NMDAR","Neuronal Signaling","Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.",305.84,"341-69-5",{"v":61,"d":"61.00"},199.45,{"v":-1,"d":"-1.00"},-3.27,"https://www.selleckchem.com/products/orphenadrine-hydrochloride.html","C18H24ClNO","free base","N/A","Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2C",4.253,1,0,6]
["S5666","Moxisylyte hydrochloride","b10","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Moxisylyte hydrochloride (thymoxamine) is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease.",315.84,"964-52-3",{"v":63,"d":"63.00"},199.47,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/moxisylyte-hydrochloride.html","C16H26ClNO3","hydrochloride","thymoxamine hydrochloride","Cl.CC(C)C1=C(OCCN(C)C)C=C(C)C(=C1)OC(C)=O",3.782,3,0,7]
["S5667","Fruquintinib (HMPL-013)","c10","L3900-22","in 10mM DMSO","VEGFR","Angiogenesis","Fruquintinib (HMPL-013) is a small molecule inhibitor with strong potency and high selectivity against VEGFR family. It inhibits VEGFR 1, 2, 3, with IC50 values of 33 nM, 35 nM and 0.5 nM, respectively and shows only weak inhibition of RET, FGFR-1 and c-kit kinases.",393.39,"1194506-26-7",{"v":6,"d":"6.00"},15.25,"<1","N/A","https://www.selleckchem.com/products/fruquintinib.html","C21H19N3O5","Tyrosine kinase inhibitor","N/A","CNC(=O)C1=C(C)OC2=CC(=CC=C12)OC3=C4C=C(OC)C(=CC4=NC=N3)OC",3.111,7,1,5]
["S5669","Isoxsuprine hydrochloride","d10","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.",337.84,"579-56-6",{"v":68,"d":"68.00"},201.28,{"v":4,"d":"4.00"},11.84,"http://www.selleckchem.com/products/isoxsuprine-hydrochloride.html","C18H24ClNO3","hydrochloride","N/A","Cl.CC(COC1=CC=CC=C1)NC(C)C(O)C2=CC=C(O)C=C2",3.384,1,3,7]
["S5670","Chloropyramine hydrochloride","e10","L3900-22","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Chloropyramine hydrochloride (Halopyramine) is a histamine receptor H1 antagonist and has anti-cholinergic, antispasmodic, and antiallergic effects.",326.26,"6170-42-9",{"v":65,"d":"65.00"},199.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/chloropyramine-hydrochloride.html","C16H21Cl2N3","hydrochloride","Halopyramine hydrochloride","Cl.CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=CC=CC=N2",4.149,1,0,6]
["S5673","Mivacurium chloride","f10","L3900-22","in 10mM DMSO","Others","Others","Mivacurium chloride is a rapid, non-depolarising, neuromuscular blocking agent of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.",1100.17,"106861-44-3",{"v":100,"d":"100.00"},{"v":90.9,"d":"90.90"},{"v":100,"d":"100.00"},{"v":90.9,"d":"90.90"},"http://www.selleckchem.com/products/mivacurium-chloride.html","C58H80Cl2N2O14","chloride","N/A","[Cl-].[Cl-].COC1=CC2=C(C=C1OC)C(CC3=CC(=C(OC)C(=C3)OC)OC)[N+](C)(CCCOC(=O)CC\\C=C\\CCC(=O)OCCC[N+]4(C)CCC5=C(C=C(OC)C(=C5)OC)C4CC6=CC(=C(OC)C(=C6)OC)OC)CC2",0.836,14,0,30]
["S5679","Dolasetron Mesylate","g10","L3900-22","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Dolasetron Mesylate (Anzemet hydrate,MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.",420.48,"115956-13-3",{"v":84,"d":"84.00"},199.77,{"v":28,"d":"28.00"},66.59,"http://www.selleckchem.com/products/dolasetron-mesylate.html","C20H24N2O6S","Mesylate","Anzemet hydrate,MDL-73147EF","C[S](O)(=O)=O.O=C1CN2C3CC(CC2CC1C3)OC(=O)C4=C[NH]C5=C4C=CC=C5",1.621,3,1,3]
["S5683","Isoproterenol sulfate dihydrate","h10","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.",556.62,"299-95-6",{"v":100,"d":"100.00"},179.66,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/isoproterenol-sulfate-dihydrate.html","C22H40N2O12S","dihydrate","N/A","O.O.CC(C)NCC(O)C1=CC=C(O)C(=C1)O.CC(C)NCC(O)C2=CC=C(O)C(=C2)O.O[S](O)(=O)=O",1.177,0,8,8]
["S5685","Desoximetasone","a11","L3900-22","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.",376.46,"382-67-2",{"v":75,"d":"75.00"},199.22,"<1","N/A","http://www.selleckchem.com/products/desoximetasone.html","C22H29FO4","Free Base","Desoxymethasone, Desoximetasonum","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1C(=O)CO",2.376,2,2,2]
["S5693","Levomilnacipran Hydrochloride","b11","L3900-22","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.",282.81,"175131-60-9",{"v":57,"d":"57.00"},201.55,{"v":57,"d":"57.00"},201.55,"http://www.selleckchem.com/products/levomilnacipran-hydrochloride.html","C15H23ClN2O","Hydrochloride","N/A","Cl.CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2",{"v":1.67,"d":"1.670"},1,1,5]
["S5698","Ketorolac tromethamine salt","c11","L3900-22","in 10mM DMSO","COX","Immunology & Inflammation","Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.",{"v":376.4,"d":"376.40"},"74103-07-4",{"v":75,"d":"75.00"},199.26,{"v":75,"d":"75.00"},199.26,"http://www.selleckchem.com/products/ketorolac-tromethamine-salt.html","C19H24N2O6","tromethamine salt","N/A","NC(CO)(CO)CO.OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",-2.028,2,4,6]
["S5701","Alvimopan dihydrate (LY246736 dihydrate)","d11","L3900-22","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.",460.56,"170098-38-1",{"v":92,"d":"92.00"},199.76,{"v":-1,"d":"-1.00"},-2.17,"https://www.selleckchem.com/products/alvimopan-dihydrate.html","C25H36N2O6","free base","N/A","O.O.CC1CN(CCC1(C)C2=CC=CC(=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(O)=O",0.096,2,2,8]
["S5703","Carvedilol Phosphate","e11","L3900-22","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.",513.48,"610309-89-2",{"v":100,"d":"100.00"},198.23,{"v":-1,"d":"-1.00"},-1.98,"https://www.selleckchem.com/products/carvedilol-phosphate.html","C24H29N2O8P.1/2H2O","Phosphate","N/A","COC1=C(OCCNCC(O)COC2=CC=CC3=C2C4=C([NH]3)C=CC=C4)C=CC=C1.O[P](O)(O)=O",{"v":4.28,"d":"4.280"},3,3,10]
["S5709","Norgestrel","f11","L3900-22","in 10mM DMSO","ROS","Immunology & Inflammation","Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.",312.45,"6533-00-2",{"v":62,"d":"62.00"},198.43,"<1","N/A","http://selleckchem.com/products/norgestrel.html","C21H28O2","free base","WY-3707, SH-70850, SH-850, FH 122-A","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S5710","Ambroxol","g11","L3900-22","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.",{"v":378.1,"d":"378.10"},"18683-91-5",{"v":76,"d":"76.00"},{"v":201,"d":"201.00"},{"v":-1,"d":"-1.00"},-2.64,"https://www.selleckchem.com/products/ambroxol.html","C13H18Br2N2O","Expectorant","N/A","NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",2.739,0,3,3]
["S5711","Deracoxib","h11","L3900-22","in 10mM DMSO","COX","Immunology & Inflammation","Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).",397.37,"169590-41-4",{"v":80,"d":"80.00"},201.32,"<1","N/A","http://selleckchem.com/products/deracoxib.html","C17H14F3N3O3S","free base","SC-046","COC1=C(F)C=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)F",3.642,4,1,5]
["S5713","Pravastatin","a2","L3900-23","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.",424.53,"81093-37-0",{"v":85,"d":"85.00"},200.22,{"v":85,"d":"85.00"},200.22,"http://www.selleckchem.com/products/pravastatin.html","C23H36O7","Free Base","CS-514","CCC(C)C(=O)OC1CC(O)C=C2C=CC(C)C(CCC(O)CC(O)CC(O)=O)C12",2.156,3,3,11]
["S5714","lurasidone","b2","L3900-23","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.",492.68,"367514-87-2",{"v":7,"d":"7.00"},14.21,"<1","N/A","http://selleckchem.com/products/lurasidone.html","C28H36N4O2S","free base","SM-13496","O=C1C2C3CCC(C3)C2C(=O)N1CC4CCCCC4CN5CCN(CC5)C6=NSC7=CC=CC=C67",4.896,3,0,5]
["S5715","Atorvastatin","c2","L3900-23","in 10mM DMSO","Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.",558.64,"134523-00-5",{"v":100,"d":"100.00"},179.01,"<1","N/A","http://www.selleckchem.com/products/atorvastatin.html","C33H35FN2O5","Free Base","N/A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC(O)=O)C3=CC=C(F)C=C3)C4=CC=CC=C4",5.555,2,3,12]
["S5716","Abemaciclib (LY2835219)","d2","L3900-23","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.",506.59,"1231929-97-7",{"v":6,"d":"6.00"},11.84,"<1","N/A","http://selleckchem.com/products/abemaciclib.html","C27H32F2N8","free base","LY2835219","CCN1CCN(CC1)CC2=CN=C(NC3=NC=C(F)C(=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)C=C2",4.957,4,1,7]
["S5719","Ceftizoxime sodium","e2","L3900-23","in 10mM DMSO","Antibiotics","Microbiology","Ceftizoxime sodium(SKF-88373) is a semisynthetic cephalosporin antibiotic that is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.",405.38,"68401-82-1",{"v":81,"d":"81.00"},199.81,{"v":81,"d":"81.00"},199.81,"http://www.selleckchem.com/products/ceftizoxime-sodium.html","C13H12N5NaO5S2","Sodium Salt","SKF-88373","[Na+].CO\\N=C(/C(=O)NC1C2SCC=C(N2C1=O)C([O-])=O)C3=CSC(=N3)N",-2.118,5,2,5]
["S5720","Glecaprevir","f2","L3900-23","in 10mM DMSO","HCV Protease","Proteases","Glecaprevir(ABT-493) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication.  It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.",838.87,"1365970-03-1",{"v":100,"d":"100.00"},119.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/glecaprevir.html","C38H46F4N6O9S","Free Base","ABT-493","CC(C)(C)C1NC(=O)OC2CCCC2OC\\C=C\\C(F)(F)C3=NC4=C(C=CC=C4)N=C3OC5CC(N(C5)C1=O)C(=O)NC6(CC6C(F)F)C(=O)N[S](=O)(=O)C7(C)CC7",3.746,11,3,7]
["S5726","Triiodothyronine","g2","L3900-23","in 10mM DMSO","THR","Metabolism","Triiodothyronine (T3, Liothyronine, 3,3',5-Triiodo-L-thyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution.",650.97,"6893-02-3",{"v":100,"d":"100.00"},153.62,"<1","N/A","http://www.selleckchem.com/products/triiodothyronine.html","C15H12I3NO4","Free Base","T3, Liothyronine, 3,3',5-Triiodo-L-thyronine","NC(CC1=CC(=C(OC2=CC=C(O)C(=C2)I)C(=C1)I)I)C(O)=O",1.448,2,2,5]
["S5728","Delapril Hydrochloride","h2","L3900-23","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.",{"v":489,"d":"489.00"},"83435-67-0",{"v":98,"d":"98.00"},200.41,"<1","N/A","https://www.selleckchem.com/products/delapril-hydrochloride.html","C26H33ClN2O5","hydrochloride","Alindapril Hydrochloride","Cl.CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N(CC(O)=O)C2CC3=C(C2)C=CC=C3",1.253,4,1,12]
["S5734","Midodrine hydrochloride","a3","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.",290.74,"43218-56-0",{"v":58,"d":"58.00"},199.49,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/midodrine-hydrochloride.html","C12H19ClN2O4","Hydrochloride","N/A","Cl.COC1=CC=C(OC)C(=C1)C(O)CNC(=O)CN",-0.166,3,3,6]
["S5735","Midodrine","b3","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.",254.28,"42794-76-3",{"v":51,"d":"51.00"},200.57,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/midodrine.html","C12H18N2O4","Free Base","N/A","COC1=CC=C(OC)C(=C1)C(O)CNC(=O)CN",-0.548,3,3,6]
["S5737","Diclofenac Epolamine","c3","L3900-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Diclofenac Epolamine (DHEP, DIEP, diclofenac hydroxyethylpyrrolidine) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.",411.32,"119623-66-4",{"v":82,"d":"82.00"},199.36,{"v":82,"d":"82.00"},199.36,"http://www.selleckchem.com/products/diclofenac-epolamine.html","C20H24Cl2N2O3","Epolamine","DHEP, DIEP, diclofenac hydroxyethylpyrrolidine","OCCN1CCCC1.OC(=O)CC2=C(NC3=C(Cl)C=CC=C3Cl)C=CC=C2",{"v":1.58,"d":"1.580"},1,2,6]
["S5739","Nebivolol","d3","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.",405.43,"118457-14-0",{"v":88,"d":"88.00"},217.05,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/nebivolol.html","C22H25F2NO4","Free Base","Bystolic,R 065824","OC(CNCC(O)C1CCC2=CC(=CC=C2O1)F)C3CCC4=C(O3)C=CC(=C4)F",3.557,2,3,6]
["S5740","Palonosetron","e3","L3900-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).",296.41,"135729-61-2",{"v":59,"d":"59.00"},199.05,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/palonosetron.html","C19H24N2O","Free Base","RS25259, RS 25259 197","O=C1N(CC2CCCC3=C2C1=CC=C3)C4CN5CCC4CC5",2.745,1,0,1]
["S5741","Quetiapine","f3","L3900-23","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.",383.51,"111974-69-7",{"v":77,"d":"77.00"},200.78,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/quetiapine.html","C21H25N3O2S","Free Base","ICI204636","OCCOCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=CC=C4",2.656,2,1,6]
["S5742","Deferoxamine mesylate (Ba 33112)","g3","L3900-23","in 10mM DMSO","Autophagy,Beta Amyloid,Ferroptosis,HIF","Autophagy","Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.",656.79,"138-14-7",{"v":100,"d":"100.00"},152.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/deferoxamine-mesylate.html","C26H52N6O11S","mesylate","Desferrioxamine B, DFOM, NSC 644468","CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.C[S](O)(=O)=O",-1.304,5,3,23]
["S5749","Chlorpromazine","h3","L3900-23","in 10mM DMSO","5-HT Receptor,Dopamine Receptor,Potassium Channel,Sodium Channel","Neuronal Signaling","Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.",318.86,"50-53-3",{"v":64,"d":"64.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/chlorpromazine.html","C17H19ClN2S","Free Base","CPZ","CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",4.739,0,0,4]
["S5752","Abametapir","a4","L3900-23","in 10mM DMSO","MMP","Proteases","Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.",184.24,"1762-34-1",{"v":37,"d":"37.00"},200.83,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/abametapir.html","C12H12N2","Free Base","HA-44, BRN 0123183","CC1=CN=C(C=C1)C2=CC=C(C)C=N2",2.876,2,0,1]
["S5753","Setipiprant (ACT-129968)","b4","L3900-23","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Setipiprant (ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.",402.42,"866460-33-5",{"v":80,"d":"80.00"},{"v":198.8,"d":"198.80"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/act-129968-setipiprant.html","C24H19FN2O3","Free Base","KYTH-105","OC(=O)C[N]1C2=C(CN(CC2)C(=O)C3=C4C=CC=CC4=CC=C3)C5=C1C=CC(=C5)F",4.002,2,0,3]
["S5754","Baricitinib phosphate","c4","L3900-23","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.",469.41,"1187595-84-1",{"v":94,"d":"94.00"},200.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/baricitinib-phosphate.html","C16H20N7O6PS","phosphate","INCB-028050 phosphate, LY-3009104 phosphate","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4.O[P](O)(O)=O",-0.108,5,1,5]
["S5761","Citric acid","d4","L3900-23","in 10mM DMSO","Others","Others","Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle.",192.12,"77-92-9",{"v":38,"d":"38.00"},197.79,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/citric-acid.html","C6H8O7","Free Base","N/A","OC(=O)CC(O)(CC(O)=O)C(O)=O",-1.319,3,0,5]
["S5763","D-Mannose","e4","L3900-23","in 10mM DMSO","Others","Others","D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining.",180.16,"3458-28-4",{"v":36,"d":"36.00"},199.82,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/d-mannose.html","C6H12O6","Free Base","N/A","OCC1OC(O)C(O)C(O)C1O",-2.514,1,4,1]
["S5766","Alfuzosin","f4","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Alfuzosin(SL 77499), a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.",389.45,"81403-80-7",{"v":78,"d":"78.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/alfuzosin.html","C19H27N5O4","Free Base","SL 77499","COC1=CC2=NC(=NC(=C2C=C1OC)N)N(C)CCCNC(=O)C3CCCO3",1.418,6,2,8]
["S5767","Aliskiren","g4","L3900-23","in 10mM DMSO","RAAS","Metabolism","Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.",551.76,"173334-57-1",{"v":100,"d":"100.00"},181.24,{"v":6,"d":"6.00"},10.87,"http://www.selleckchem.com/products/aliskiren.html","C30H53N3O6","Free Base","CGP 60536","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C",3.327,5,4,19]
["S5768","Fenoterol hydrobromide","h4","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.",384.26,"1944-12-3",{"v":77,"d":"77.00"},200.39,{"v":11,"d":"11.00"},28.63,"http://www.selleckchem.com/products/fenoterol-hydrobromide.html","C17H22BrNO4","hydrobromide","Phenoterol hydrobromide","Br.CC(CC1=CC=C(O)C=C1)NCC(O)C2=CC(=CC(=C2)O)O",2.904,0,5,6]
["S5769","Fenoterol","a5","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity.",303.35,"13392-18-2",{"v":61,"d":"61.00"},201.09,"<1","N/A","http://www.selleckchem.com/products/fenoterol.html","C17H21NO4","Free Base","Phenoterol","CC(CC1=CC=C(O)C=C1)NCC(O)C2=CC(=CC(=C2)O)O",2.413,0,5,6]
["S5771","Sulforaphane","b5","L3900-23","in 10mM DMSO","HDAC,Heme Oxygenase,NF-κB,Nrf2,ROS","Immunology & Inflammation","Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,",177.29,"4478-93-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/sulforaphane.html","C6H11NOS2","Free Base","N/A","C[S](=O)CCCCN=C=S",1.157,2,0,5]
["S5776","Proflavine","c5","L3900-23","in 10mM DMSO","Bacterial","Microbiology","Proflavine (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria. It is a topical antiseptic used mainly in wound dressings.",209.25,"92-62-6",{"v":23,"d":"23.00"},109.92,{"v":1,"d":"1.00"},4.78,"http://www.selleckchem.com/products/proflavine.html","C13H11N3","Free Base","3,6-Diaminoacridine","NC1=CC2=NC3=CC(=CC=C3C=C2C=C1)N",{"v":1.86,"d":"1.860"},1,2,0]
["S5778","Esmolol","d5","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.",295.37,"81147-92-4",{"v":59,"d":"59.00"},199.75,{"v":59,"d":"59.00"},199.75,"http://www.selleckchem.com/products/esmolol.html","C16H25NO4","Free Base","N/A","COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1",1.978,3,2,10]
["S5779","Trimetazidine","e5","L3900-23","in 10mM DMSO","Others","Metabolism","Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation.",266.34,"5011-34-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/trimetazidine.html","C14H22N2O3","Free Base","N/A","COC1=CC=C(CN2CCNCC2)C(=C1OC)OC",1.275,3,1,5]
["S5780","Prazosin","f5","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.",{"v":383.4,"d":"383.40"},"19216-56-9",{"v":77,"d":"77.00"},200.83,{"v":1,"d":"1.00"},2.61,"http://www.selleckchem.com/products/prazosin.html","C19H21N5O4","Free Base","N/A","COC1=CC2=NC(=NC(=C2C=C1OC)N)N3CCN(CC3)C(=O)C4=CC=CO4",2.107,6,1,4]
["S5781","Raloxifene","g5","L3900-23","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.",473.58,"84449-90-1",{"v":95,"d":"95.00"},{"v":200.6,"d":"200.60"},{"v":1,"d":"1.00"},2.11,"http://www.selleckchem.com/products/raloxifene.html","C28H27NO4S","Free Base","Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129","OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.461,2,2,7]
["S5782","Doxazosin","h5","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Doxazosin(UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.",451.48,"74191-85-8",{"v":31,"d":"31.00"},68.66,{"v":1,"d":"1.00"},2.21,"http://www.selleckchem.com/products/doxazosin.html","C23H25N5O5","Free Base","UK 33274","COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=C(O4)C=CC=C5)N",2.485,7,1,4]
["S5783","Montelukast","a6","L3900-23","in 10mM DMSO","LTR","Immunology & Inflammation","Montelukast(MK0476) is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.",586.18,"158966-92-8",{"v":100,"d":"100.00"},{"v":170.6,"d":"170.60"},{"v":1,"d":"1.00"},1.71,"http://www.selleckchem.com/products/montelukast.html","C35H36ClNO3S","Free Base","MK0476","CC(C)(O)C1=CC=CC=C1CCC(SCC2(CC2)CC(O)=O)C3=CC=CC(=C3)\\C=C\\C4=CC=C5C=CC(=CC5=N4)Cl",8.284,2,0,12]
["S5784","Vancomycin","b6","L3900-23","in 10mM DMSO","Antibiotics,Antibiotics for Plant Cell Culture,Bacterial","Microbiology","Vancomycin is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria.",1449.25,"1404-90-6",{"v":29,"d":"29.00"},20.01,{"v":1,"d":"1.00"},0.69,"http://www.selleckchem.com/products/vancomycin.html","C66H75Cl2N9O24","Free Base","N/A","CNC(CC(C)C)C(=O)NC1C(O)C2=CC(=C(OC3=C(OC4OC(CO)C(O)C(O)C4OC5CC(C)(N)C(O)C(C)O5)C6=CC(=C3)C(NC(=O)C(CC(N)=O)NC1=O)C(=O)NC7C(=O)NC(C(O)C8=CC(=C(O6)C=C8)Cl)C(=O)NC(C(O)=O)C9=C(C(=CC(=C9)O)O)C%10=C(O)C=CC7=C%10)C=C2)Cl",-2.926,14,18,13]
["S5787","Dronedarone","c6","L3900-23","in 10mM DMSO","Adrenergic Receptor","Transmembrane Transporters","Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).",556.76,"141626-36-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/dronedarone.html","C31H44N2O5S","Free Base","SR33589","CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=C2C=C(N[S](C)(=O)=O)C=C3",7.015,5,1,18]
["S5793","Motesanib (AMG-706)","d6","L3900-23","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively.",373.45,"453562-69-1",{"v":75,"d":"75.00"},200.83,{"v":1,"d":"1.00"},2.68,"http://www.selleckchem.com/products/motesanib-amg-706.html","C22H23N5O","Free Base","N/A","CC1(C)CNC2=CC(=CC=C12)NC(=O)C3=C(NCC4=CC=NC=C4)N=CC=C3",2.721,3,3,5]
["S5795","Rasagiline","e6","L3900-23","in 10mM DMSO","MAO","Metabolism","Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.",171.24,"136236-51-6",{"v":34,"d":"34.00"},198.55,{"v":4,"d":"4.00"},23.36,"http://www.selleckchem.com/products/rasagiline.html","C12H13N","Free Base","TVP-1012","C#CCNC1CCC2=C1C=CC=C2",3.119,0,1,2]
["S5796","Vanoxerine dihydrochloride","f6","L3900-23","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Vanoxerine (GBR-12909) is a potent and selective inhibitor of the presynaptic dopamine uptake complex.",523.49,"67469-78-7",{"v":17,"d":"17.00"},32.47,{"v":5,"d":"5.00"},9.55,"http://www.selleck.cn/products/vanoxerine-dihydrochloride.html","C28H34Cl2F2N2O","dihydrochloride","GBR-12909","Cl.Cl.FC1=CC=C(C=C1)C(OCCN2CCN(CCCC3=CC=CC=C3)CC2)C4=CC=C(F)C=C4",6.878,1,0,10]
["S5803","Alrestatin","g6","L3900-23","in 10mM DMSO","Aldose Reductase","Metabolism","Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.",255.23,"51411-04-2",{"v":51,"d":"51.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/alrestatin.html","C14H9NO4","Free Base","N/A","OC(=O)CN1C(=O)C2=C3C(=CC=C2)C=CC=C3C1=O",1.252,3,0,2]
["S5804","N-Acetylcysteine amide","h6","L3900-23","in 10mM DMSO","HIF,Immunology & Inflammation related,NF-κB,ROS","Immunology & Inflammation","N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.",162.21,"38520-57-9",{"v":32,"d":"32.00"},197.28,{"v":32,"d":"32.00"},197.28,"http://www.selleckchem.com/products/n-acetylcysteine-amide.html","C5H10N2O2S","Free Base","N/A","CC(=O)NC(CS)C(N)=O",-1.205,2,2,3]
["S5805","Allopregnanolone","a7","L3900-23","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.",318.49,"516-54-1",{"v":64,"d":"64.00"},200.95,"<1","N/A","http://www.selleckchem.com/products/allopregnanolone.html","C21H34O2","Free Base","N/A","CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C",3.874,1,1,1]
["S5807","HMN-176","b7","L3900-23","in 10mM DMSO","PLK","Cell Cycle","HMN-176 is an active metabolite of HMN-214, which has a potent antitumor activity in mouse xenograft models. HMN-176 effectively inhibits PLK-1 by interference with its normal subcellular spatial distribution at centrosomes and along the cytoskeletal structure.",382.43,"173529-10-7",{"v":76,"d":"76.00"},198.73,"<1","N/A","http://www.selleckchem.com/products/hmn-176.html","C20H18N2O4S","Free Base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(C=CC=C2)\\C=C\\C3=CC=[N+]([O-])C=C3",2.292,3,1,6]
["S5808","Relugolix","c7","L3900-23","in 10mM DMSO","GNRH Receptor","Endocrinology & Hormones","Relugolix (RVT-601, TAK-385) is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with IC50 of 0.33 nM and 0.32 nM for human GnRHR and monkey GnRHR, respectively.",623.63,"737789-87-6",{"v":61,"d":"61.00"},97.81,"<1","N/A","http://www.selleckchem.com/products/relugolix.html","C29H27F2N7O5S","Free Base","RVT-601, TAK-385","CONC(=O)NC1=CC=C(C=C1)C2=C(CN(C)C)C3=C(S2)N(CC4=C(F)C=CC=C4F)C(=O)N(C3=O)C5=NN=C(OC)C=C5",4.623,7,2,9]
["S5811","Kevetrin hydrochloride","d7","L3900-23","in 10mM DMSO","p53","Apoptosis","Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.",179.67,"66592-89-0",{"v":36,"d":"36.00"},200.37,{"v":36,"d":"36.00"},200.37,"http://www.selleckchem.com/products/kevetrin-hydrochloride.html","C5H10ClN3S","hydrochloride","Thioureidobutyronitrile HCl","Cl.NC(=N)SCCCC#N",1.105,0,1,4]
["S5812","Choline Fenofibrate","e7","L3900-23","in 10mM DMSO","PPAR","Metabolism","Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.",421.91,"856676-23-8",{"v":5,"d":"5.00"},11.85,{"v":9,"d":"9.00"},21.33,"http://www.selleckchem.com/products/choline-fenofibrate.html","C22H28ClNO5","Free Base","ABT-335","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C([O-])=O.C[N+](C)(C)CCO",1.111,2,1,7]
["S5814","cariporide","f7","L3900-23","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.",283.35,"159138-80-4",{"v":87,"d":"87.00"},307.04,"<1","N/A","http://www.selleckchem.com/products/cariporide.html","C12H17N3O3S","Free Base","HOE-642","CC(C)C1=CC=C(C=C1[S](C)(=O)=O)C(=O)NC(N)=N",1.386,3,2,4]
["S5818","acalisib (GS-9820)","g7","L3900-23","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.",{"v":401.4,"d":"401.40"},"870281-34-8",{"v":80,"d":"80.00"},{"v":199.3,"d":"199.30"},{"v":1,"d":"1.00"},2.49,"http://www.selleckchem.com/products/acalisib-gs-9820.html","C21H16FN7O","Free Base","CAL-120","CC(NC1=NC=NC2=C1[NH]C=N2)C3=NC4=C(C=C(F)C=C4)C(=O)N3C5=CC=CC=C5",3.097,5,2,4]
["S5839","L-Kynurenine","h7","L3900-23","in 10mM DMSO","AhR","Metabolism","L-Kynurenine ((S)-Kynurenine) is a aryl hydrocarbon receptor agonist. L-Kynurenine is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway.",208.21,"2922-83-0",{"v":42,"d":"42.00"},201.72,{"v":3,"d":"3.00"},14.41,"http://www.selleckchem.com/products/l-kynurenine.html","C10H12N2O3","Free Base","(S)-Kynurenine","NC(CC(=O)C1=C(N)C=CC=C1)C(O)=O",-2.752,2,2,4]
["S5840","Palifosfamide","a8","L3900-23","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.",221.02,"31645-39-3",{"v":44,"d":"44.00"},199.08,{"v":13,"d":"13.00"},58.82,"http://www.selleckchem.com/products/palifosfamide.html","C4H11Cl2N2O2P","Free Base","ZIO-201, Isophosphamide mustard","O[P](=O)(NCCCl)NCCCl",0.018,1,2,6]
["S5842","Cabergoline","b8","L3900-23","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.",{"v":451.6,"d":"451.60"},"81409-90-7",{"v":90,"d":"90.00"},199.29,{"v":1,"d":"1.00"},2.21,"http://www.selleckchem.com/products/cabergoline.html","C26H37N5O2","Free Base","FCE-21336","CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=C[NH]C4=C3C2=CC=C4)N(CC=C)C1",3.036,2,2,8]
["S5843","Cinitapride Hydrogen Tartrate","c8","L3900-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors",552.57,"1207859-16-2",{"v":59,"d":"59.00"},106.77,{"v":5,"d":"5.00"},9.05,"http://www.selleckchem.com/products/cinitapride-hydrogen-tartrate.html","C25H36N4O10","Hydrogen Tartrate","N/A","CCOC1=CC(=C(C=C1C(=O)NC2CCN(CC2)CC3CCC=CC3)[N+]([O-])=O)N.OC(C(O)C(O)=O)C(O)=O",-2.325,4,4,10]
["S5845","Chalcone","d8","L3900-23","in 10mM DMSO","Fungal","Microbiology","Chalcone (benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones with antibacterial, antifungal, antitumor and anti-inflammatory properties.",208.26,"94-41-7",{"v":42,"d":"42.00"},201.67,{"v":1,"d":"1.00"},{"v":4.8,"d":"4.80"},"http://www.selleckchem.com/products/chalcone.html","C15H12O","Free Base","benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone","O=C(\\C=C\\C1=CC=CC=C1)C2=CC=CC=C2",3.701,1,0,3]
["S5847","Ethacrynate Sodium","e8","L3900-23","in 10mM DMSO","Proton Pump","Transmembrane Transporters","Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.",325.12,"6500-81-8",{"v":65,"d":"65.00"},199.93,{"v":65,"d":"65.00"},199.93,"http://www.selleck.cn/products/ethacrynate-sodium.html","C13H11Cl2NaO4","Sodium","ethacrynic acid sodium","[Na+].CCC(=C)C(=O)C1=C(Cl)C(=C(OCC([O-])=O)C=C1)Cl",2.489,2,0,6]
["S5848","Frovatriptan Succinate","f8","L3900-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.",361.39,"158930-09-7",{"v":72,"d":"72.00"},199.23,{"v":72,"d":"72.00"},199.23,"http://www.selleck.cn/products/frovatriptan-succinate.html","C18H23N3O5","Succinate","SB 209509 Succinate,VML 251 Succinate","CNC1CCC2=C(C1)C3=C([NH]2)C=CC(=C3)C(N)=O.OC(=O)CCC(O)=O",{"v":-1.65,"d":"-1.650"},3,3,5]
["S5857","Trazodone","g8","L3900-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.",371.86,"19794-93-5",{"v":45,"d":"45.00"},121.01,"<1","N/A","http://www.selleck.cn/products/trazodone.html","C19H22ClN5O","Free Base","AF-1161","ClC1=CC(=CC=C1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2",2.418,2,0,5]
["S5858","Vilazodone","h8","L3900-23","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.",441.52,"163521-12-8",{"v":88,"d":"88.00"},199.31,{"v":1,"d":"1.00"},2.26,"https://www.selleckchem.com/products/vilazodone.html","C26H27N5O2","Free Base","EMD-68843, SB-659746A","NC(=O)C1=CC2=C(O1)C=CC(=C2)N3CCN(CCCCC4=C[NH]C5=C4C=C(C=C5)C#N)CC3",4.536,2,2,7]
["S5861","Lercanidipine","a9","L3900-23","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension.",611.73,"100427-26-7",{"v":55,"d":"55.00"},89.91,{"v":1,"d":"1.00"},1.63,"http://www.selleckchem.com/products/lercanidipine.html","C36H41N3O6","Free Base","N/A","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C",6.132,4,1,14]
["S5862","Metoclopramide","b9","L3900-23","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting.",{"v":299.8,"d":"299.80"},"364-62-5",{"v":60,"d":"60.00"},200.13,{"v":1,"d":"1.00"},3.34,"http://www.selleckchem.com/products/metoclopramide.html","C14H22ClN3O2","Free Base","N/A","CCN(CC)CCNC(=O)C1=C(OC)C=C(N)C(=C1)Cl",1.775,2,2,7]
["S5863","Metronidazole Benzoate","c9","L3900-23","in 10mM DMSO","Bacterial","Microbiology","Metronidazole Benzoate (Benzoyl metronidazole) is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.",275.26,"13182-89-3",{"v":55,"d":"55.00"},199.81,{"v":1,"d":"1.00"},3.63,"http://www.selleckchem.com/products/metronidazole-benzoate.html","C13H13N3O4","Benzoate","Benzoyl metronidazole","CC1=NC=C([N]1CCOC(=O)C2=CC=CC=C2)[N+]([O-])=O",1.706,3,0,6]
["S5869","Cortisone","d9","L3900-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress. It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury.",360.44,"53-06-5",{"v":72,"d":"72.00"},199.76,{"v":1,"d":"1.00"},2.77,"https://www.selleckchem.com/products/cortisone.html","C21H28O5","Free Base","N/A","CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)CO)C4(C)CC(=O)C23",{"v":1.24,"d":"1.240"},3,1,2]
["S5873","Scopolamine HBr trihydrate","e9","L3900-23","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.",438.31,"6533-68-2",{"v":88,"d":"88.00"},200.77,{"v":88,"d":"88.00"},200.77,"https://www.selleckchem.com/products/scopolamine-hbr-trihydrate.html","C17H28BrNO7","HBr trihydrate","N/A","O.O.O.Br.CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",0.693,3,1,5]
["S5874","D-Carnitine hydrochloride","f9","L3900-23","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.",197.66,"10017-44-4",{"v":40,"d":"40.00"},202.37,{"v":40,"d":"40.00"},202.37,"https://www.selleckchem.com/products/d-carnitine-hydrochloride.html","C7H16ClNO3","hydrochloride","(S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride","[Cl-].C[N+](C)(C)CC(O)CC(O)=O",{"v":-4.49,"d":"-4.490"},1,1,4]
["S5887","Khellin","g9","L3900-23","in 10mM DMSO","Anti-infection","Microbiology","Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.",260.24,"82-02-0",{"v":26,"d":"26.00"},99.91,"<1","N/A","http://www.selleck.cn/products/khellin.html","C14H12O5","Free Base","Amicardine, Corafurone, Methafrone, Kelourin, Rykellin, Visammin, Ammispasmin, Ammivisnagen, Gynokhellan, Interkellin, Interkhellin, Amikellin, Ammipuran, Benecardin, Deltoside, Kelicorin, Khelangin, Khellamine, Khellanals, Khellinorm, Medekellin, Visammimix, Viscardan, Visnagalin, Kalangin, Kelincor","COC1=C2OC(=CC(=O)C2=C(OC)C3=C1OC=C3)C",2.172,5,0,2]
["S5901","Canagliflozin hemihydrate","h9","L3900-23","in 10mM DMSO","SGLT","GPCR & G Protein","Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.",907.05,"928672-86-0",{"v":100,"d":"100.00"},110.25,"<1","N/A","http://www.selleckchem.com/products/canagliflozin-hemihydrate.html","C48H52F2O11S2","hemihydrate","N/A","O.CC1=C(CC2=CC=C(S2)C3=CC=C(F)C=C3)C=C(C=C1)C4OC(CO)C(O)C(O)C4O.CC5=C(CC6=CC=C(S6)C7=CC=C(F)C=C7)C=C(C=C5)C8OC(CO)C(O)C(O)C8O",6.686,2,8,10]
["S5903","JANEX-1","a10","L3900-23","in 10mM DMSO","JAK","JAK/STAT","JANEX-1 (WHI-P131) is a small molecule inhibitor of JAK3 that selectively inhibits JAK3 at an IC50 of 78 µM without altering the activity of JAK1 or JAK2, or any other protein tyrosine kinases (IC50 ≥ 350 µM).",297.31,"202475-60-3",{"v":5,"d":"5.00"},16.82,"<1","N/A","http://www.selleckchem.com/products/janex-1.html","C16H15N3O3","Free Base","WHI-P131","COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=C(O)C=C3",3.202,4,2,4]
["S5904","WHI-P97","b10","L3900-23","in 10mM DMSO","JAK","JAK/STAT","WHI-P97 is a potent inhibitor of JAK-3 with an estimated Ki value of 0.09 μM in modeling studies and a measured IC50 value of 2.5 μM in EGFR kinase inhibition assays.",{"v":455.1,"d":"455.10"},"211555-05-4",{"v":8,"d":"8.00"},17.58,"<1","N/A","http://www.selleckchem.com/products/whi-p97.html","C16H13Br2N3O3","Free Base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC(=C(O)C(=C3)Br)Br",4.699,4,2,4]
["S5905","Suberohydroxamic acid","c10","L3900-23","in 10mM DMSO","HDAC","Epigenetics","Suberohydroxamic acid (suberic bishydroxamic acid) is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.",204.22,"38937-66-5",{"v":41,"d":"41.00"},200.76,{"v":4,"d":"4.00"},19.59,"http://www.selleckchem.com/products/suberohydroxamic-acid.html","C8H16N2O4","Free Base","suberic bishydroxamic acid","ONC(=O)CCCCCCC(=O)NO",0.235,2,2,7]
["S5909","Anagliptin","d10","L3900-23","in 10mM DMSO","DPP","Proteases","Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.",383.45,"739366-20-2",{"v":77,"d":"77.00"},200.81,{"v":20,"d":"20.00"},52.16,"http://www.selleckchem.com/products/anagliptin.html","C19H25N7O2","Free Base","N/A","CC1=N[N]2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCCC3C#N",-0.629,4,2,6]
["S5911","Bictegravir","e10","L3900-23","in 10mM DMSO","COVID-19,Integrase","Microbiology","Bictegravir (GS-9883) is a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase.",449.38,"1611493-60-7",{"v":90,"d":"90.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/bictegravir.html","C21H18F3N3O5","Free Base","GS-9883","OC1=C2N(CC3OC4CCC(C4)N3C2=O)C=C(C(=O)NCC5=C(F)C=C(F)C=C5F)C1=O",0.646,4,2,3]
["S5917","Solcitinib","f10","L3900-23","in 10mM DMSO","JAK","JAK/STAT","Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.",389.45,"1206163-45-2",{"v":30,"d":"30.00"},77.03,"<1","N/A","http://www.selleckchem.com/products/solcitinib.html","C22H23N5O2","Free Base","GLPG0778, GSK2586184","CC1(C)CN(C1)C(=O)C2=CC=C(C=C2)C3=CC=CC4=NC(=N[N]34)NC(=O)C5CC5",3.118,4,1,4]
["S5923","Celiprolol hydrochloride","g10","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity.",415.95,"57470-78-7",{"v":83,"d":"83.00"},199.54,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/celiprolol-hydrochloride.html","C20H34ClN3O4","hydrochloride","N/A","Cl.CCN(CC)C(=O)NC1=CC(=C(OCC(O)CNC(C)(C)C)C=C1)C(C)=O",1.978,3,3,10]
["S5924","Olanexidine Hydrochloride semihydrate","h10","L3900-23","in 10mM DMSO","Bacterial","Microbiology","Olanexidine (OPB-2045, OPB-2045G) is a monobiguanide compound with bactericidal activity.",{"v":417.8,"d":"417.80"},"218282-71-4",{"v":82,"d":"82.00"},196.27,{"v":1,"d":"1.00"},2.39,"http://www.selleckchem.com/products/olanexidine-hydrochloride-semihydrate.html","C17H29Cl3N5O0.5","Hydrochloride semihydrate","OPB-2045, OPB-2045G","Cl.CCCCCCCCNC(=N)NC(=N)NCC1=CC=C(Cl)C(=C1)Cl",{"v":6.44,"d":"6.440"},0,3,13]
["S5925","Olodaterol hydrochloride","a11","L3900-23","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.",{"v":422.9,"d":"422.90"},"869477-96-3",{"v":85,"d":"85.00"},200.99,{"v":85,"d":"85.00"},200.99,"http://www.selleckchem.com/products/olodaterol-hydrochloride.html","C21H27ClN2O5","hydrochloride","BI-1744 HCl","Cl.COC1=CC=C(CC(C)(C)NCC(O)C2=C3OCC(=O)NC3=CC(=C2)O)C=C1",2.257,3,4,7]
["S5926","Pitolisant hydrochloride","b11","L3900-23","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Pitolisant (Tiprolisant, BF-2649) acts as a high-affinity competitive antagonist (Ki=0.16 nM) and as an inverse agonist (EC50=1.5 nM) at the human histamine H3 receptor subtype.",332.31,"903576-44-3",{"v":66,"d":"66.00"},198.61,{"v":66,"d":"66.00"},198.61,"http://www.selleckchem.com/products/pitolisant-hydrochloride.html","C17H27Cl2NO","hydrochloride","Tiprolisant hydrochloride, BF-2649 HCl","Cl.ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1",4.576,1,0,8]
["S5927","Proguanil","c11","L3900-23","in 10mM DMSO","Anti-infection,DHFR","Microbiology","Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.",253.73,"500-92-5",{"v":51,"d":"51.00"},{"v":201,"d":"201.00"},{"v":1,"d":"1.00"},3.94,"http://www.selleckchem.com/products/proguanil.html","C11H16ClN5","Free Base","chlorguanide, chloroguanide","CC(C)NC(=N)NC(=N)NC1=CC=C(Cl)C=C1",2.226,0,3,6]
["S5930","PNU 282987 HCl","d11","L3900-23","in 10mM DMSO","AChR","Metabolism","PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor.",301.21,"123464-89-1",{"v":46,"d":"46.00"},152.72,{"v":11,"d":"11.00"},36.52,"https://www.selleckchem.com/products/pnu-282987-hcl.html","C14H18Cl2N2O","Free Base","N/A","Cl.ClC1=CC=C(C=C1)C(=O)NC2CN3CCC2CC3",{"v":2.62,"d":"2.620"},1,1,2]
["S5932","BIA 10-2474","e11","L3900-23","in 10mM DMSO","FAAH","Metabolism","BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo.",300.36,"1233855-46-3",{"v":4,"d":"4.00"},13.32,"<1","N/A","http://www.selleck.cn/products/bia-10-2474.html","C16H20N4O2","Free Base","N/A","CN(C1CCCCC1)C(=O)[N]2C=NC(=C2)C3=CC=C[N+](=C3)[O-]",1.719,2,0,2]
["S5935","Alvimopan","f11","L3900-23","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.",424.53,"156053-89-3",{"v":85,"d":"85.00"},200.22,{"v":1,"d":"1.00"},2.36,"http://www.selleckchem.com/products/alvimopan.html","C25H32N2O4","Free Base","LY 246736, ADL 8-2698","CC1CN(CCC1(C)C2=CC=CC(=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(O)=O",{"v":0.51,"d":"0.510"},2,2,8]
["S5936","Cefazolin","g11","L3900-23","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Cefazolin(Cephazolin) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.",454.51,"25953-19-9",{"v":91,"d":"91.00"},200.22,"<1","N/A","http://www.selleck.cn/products/cefazolin.html","C14H14N8O4S3","Free Base","Cephazolin","CC1=NN=C(SCC2=C(N3C(SC2)C(NC(=O)C[N]4C=NN=N4)C3=O)C(O)=O)S1",-1.333,8,1,7]
["S5938","Benazepril","h11","L3900-23","in 10mM DMSO","RAAS","Endocrinology & Hormones","Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.",424.49,"86541-75-5",{"v":85,"d":"85.00"},200.24,"<1","N/A","http://www.selleck.cn/products/benazepril.html","C24H28N2O5","Free Base","N/A","CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=C(C=CC=C3)N(CC(O)=O)C2=O",0.621,4,1,10]
["S5939","Bendamustine (SDX105)","a2","L3900-24","in 10mM DMSO","Others","Others","Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.",358.26,"16506-27-7",{"v":72,"d":"72.00"},200.97,"<1","N/A","http://www.selleck.cn/products/bendamustine.html","C16H21Cl2N3O2","Free Base","SDX105","C[N]1C(=NC2=C1C=CC(=C2)N(CCCl)CCCl)CCCC(O)=O",3.606,2,0,9]
["S5940","Bepotastine","b2","L3900-24","in 10mM DMSO","COVID-19,Histamine Receptor","Neuronal Signaling","Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease.",388.89,"125602-71-3",{"v":78,"d":"78.00"},200.57,{"v":78,"d":"78.00"},200.57,"http://www.selleck.cn/products/bepotastine.html","C21H25ClN2O3","Free Base","N/A","OC(=O)CCCN1CCC(CC1)OC(C2=CC=C(Cl)C=C2)C3=CC=CC=N3",0.208,3,0,8]
["S5944","Butenafine","c2","L3900-24","in 10mM DMSO","Fungal","Microbiology","Butenafine is a synthetic benzylamine antifungal agent.",317.47,"101828-21-1",{"v":63,"d":"63.00"},198.44,"<1","N/A","http://www.selleck.cn/products/butenafine.html","C23H27N","Free Base","N/A","CN(CC1=CC=C(C=C1)C(C)(C)C)CC2=CC=CC3=C2C=CC=C3",5.795,0,0,5]
["S5948","Amodiaquine","d2","L3900-24","in 10mM DMSO","DNA/RNA Synthesis,Parasite","Microbiology","Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.",355.86,"86-42-0",{"v":71,"d":"71.00"},199.52,"<1","N/A","http://www.selleck.cn/products/amodiaquine.html","C20H22ClN3O","Free Base","N/A","CCN(CC)CC1=CC(=CC=C1O)NC2=CC=NC3=C2C=CC(=C3)Cl",{"v":4.76,"d":"4.760"},1,2,6]
["S5950","Fingolimod","e2","L3900-24","in 10mM DMSO","S1P Receptor","Neuronal Signaling","Fingolimod (FTY-720A, FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.",307.47,"162359-55-9",{"v":13,"d":"13.00"},42.28,{"v":1,"d":"1.00"},3.25,"https://www.selleckchem.com/products/fingolimod.html","C19H33NO2","Free Base","FTY-720A, FTY-720","CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",4.198,0,3,12]
["S5952","Baloxavir marboxil","f2","L3900-24","in 10mM DMSO","Antiviral","Microbiology","Baloxavir marboxil(S-033188), a cap-endonuclease inhibitor, is an antiviral drug.",571.55,"1985606-14-1",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://www.selleck.cn/products/baloxavir-marboxil.html","C27H23F2N3O7S","free base","S-033188","COC(=O)OCOC1=C2N(C=CC1=O)N(C3COCCN3C2=O)C4C5=C(CSC6=C4C=CC=C6)C(=C(F)C=C5)F",2.602,7,0,6]
["S6002","Disufenton sodium","g2","L3900-24","in 10mM DMSO","Others","Others","Disufenton Sodium (NXY-059, Cerovive) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.",381.33,"168021-79-2",{"v":76,"d":"76.00"},{"v":199.3,"d":"199.30"},{"v":76,"d":"76.00"},{"v":199.3,"d":"199.30"},"http://selleckchem.com/products/NXY-059.html","C11H13NNa2O7S2","Disodium salt","NXY-059, Cerovive","[Na+].[Na+].CC(C)(C)/[N+]([O-])=C/C1=CC=C(C=C1[S]([O-])(=O)=O)[S]([O-])(=O)=O",-3.972,0,0,4]
["S6003","Ataluren (PTC124)","h2","L3900-24","in 10mM DMSO","CFTR","Transmembrane Transporters","Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.",284.24,"775304-57-9",{"v":57,"d":"57.00"},200.53,"<1","N/A","http://selleckchem.com/products/PTC124.html","C15H9FN2O3","free base","N/A","OC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C3=CC=CC=C3F",{"v":2.98,"d":"2.980"},4,0,3]
["S6005","VX-702","a3","L3900-24","in 10mM DMSO","p38 MAPK","MAPK","VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.",{"v":404.3,"d":"404.30"},"745833-23-2",{"v":81,"d":"81.00"},200.35,"<1","N/A","http://selleckchem.com/products/VX-702.html","C19H12F4N4O2","free base","N/A","NC(=O)N(C1=NC(=C(C=C1)C(N)=O)C2=C(F)C=C(F)C=C2)C3=C(F)C=CC=C3F",3.682,3,2,4]
["S6010","Sodium L-lactate","b3","L3900-24","in 10mM DMSO","Others","Others","Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.",113.07,"867-56-1",{"v":22,"d":"22.00"},196.32,"N/A","N/A","http://www.selleck.cn/products/sodium-l-lactate.html","C3H5NaO3","free base","N/A","[Na+].CC(O)C([O-])=O",-1.867,0,1,1]
["S6014","Isonicotinic acid","c3","L3900-24","in 10mM DMSO","Others","Others","Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid.",123.11,"55-22-1",{"v":5,"d":"5.00"},40.61,"N/A","N/A","http://www.selleck.cn/products/isonicotinic-acid.html","C6H5NO2","free base","Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid","OC(=O)C1=CC=NC=C1",0.309,2,0,1]
["S6047","Lactose","d3","L3900-24","in 10mM DMSO","Others","Others","Lactose is a disaccharide naturally found in milk and dairy.",{"v":342.3,"d":"342.30"},"63-42-3",{"v":34,"d":"34.00"},99.33,"N/A","N/A","http://www.selleck.cn/products/lactose.html","C12H22O11","free base","N/A","OCC(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)C(O)C=O",-4.538,3,8,8]
["S6058","β-Caryophyllene","e3","L3900-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","β-Caryophyllene is a natural bicyclic sesquiterpene that is a constituent of many essential oils. It acts as a non-steroidal anti-inflammatory drug, a fragrance and a metabolite.",204.35,"87-44-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/caryophyllene.html","C15H24","free base","N/A","CC/1=C\\CCC(=C)C2CC(C)(C)C2CC1",4.753,0,0,0]
["S6068","Doxycycline monohydrate","f3","L3900-24","in 10mM DMSO","Antibiotics","Microbiology","Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity.",462.45,"17086-28-1",{"v":47,"d":"47.00"},101.63,"N/A","N/A","http://www.selleck.cn/products/doxycycline-monohydrate.html","C22H26N2O9","monohydrate","N/A","O.CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",-0.959,3,5,2]
["S6112","Oxalacetic acid","g3","L3900-24","in 10mM DMSO","Acetyl-CoA carboxylase","Metabolism","Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.",132.07,"328-42-7",{"v":26,"d":"26.00"},196.87,"N/A","N/A","http://www.selleck.cn/products/oxalacetic-acid.html","C4H4O5","free base","Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid","OC(=O)CC(=O)C(O)=O",-0.518,3,0,3]
["S6113","Tridecanoic acid","h3","L3900-24","in 10mM DMSO","Others","Others","Tridecanoic acid (Tridecylic acid) is a 13-carbon saturated fatty acid found in many foods, some of which are nutmeg, muskmelon, black elderberry, and coconut.",214.34,"638-53-9",{"v":42,"d":"42.00"},195.95,"N/A","N/A","http://www.selleck.cn/products/tridecanoic-acid.html","C13H26O2","free base","Tridecylic acid","CCCCCCCCCCCCC(O)=O",5.024,1,0,11]
["S6118","Terpinen-4-ol","a4","L3900-24","in 10mM DMSO","Fungal","Microbiology","Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties.,",154.25,"562-74-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/terpinen-4-ol.html","C10H18O","free base","N/A","CC(C)C1(O)CCC(=CC1)C",{"v":2.55,"d":"2.550"},0,0,1]
["S6185","Arachidonic acid","b4","L3900-24","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.,",304.47,"506-32-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/arachidonic-acid.html","C20H32O2","free base","Arachidonate","CCCCC\\C=C/C/C=C\\C\\C=C/C/C=C\\CCCC(O)=O",6.439,1,0,14]
["S6202","Butylated hydroxytoluene","c4","L3900-24","in 10mM DMSO","Others","Others","Butylated hydroxytoluene (dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT) is a lipophilic organic compound that is useful for its antioxidant properties.",220.35,"128-37-0",44.07,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/butylated-hydroxytoluene.html","C15H24O","free base","dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT","CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C",4.875,0,1,2]
["S6207","Levulinic acid","d4","L3900-24","in 10mM DMSO","Others","Others","Levulinic acid (4-oxopentanoic acid, β-Acetylpropionic acid, 3-Acetopropionic acid, γ-ketovaleric acid) is used as a precursor for pharmaceuticals, plasticizers, and various other additives.",116.12,"123-76-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/levulinic-acid.html","C5H8O3","free base","4-oxopentanoic acid, β-Acetylpropionic acid, 3-Acetopropionic acid, γ-ketovaleric acid","CC(=O)CCC(O)=O",-0.259,2,0,3]
["S6234","Pentadecanoic acid","e4","L3900-24","in 10mM DMSO","Others","Others","Pentadecanoic acid is a saturated fatty acid of exogenous (primarily ruminant) origin. It also has a role as a plant metabolite, a food component, a Daphnia magna metabolite, a human blood serum metabolite and an algal metabolite.",{"v":242.4,"d":"242.40"},"1002-84-2",48.48,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/pentadecanoic-acid.html","C15H30O2","free base","N/A","CCCCCCCCCCCCCCC(O)=O",5.936,1,0,13]
["S6243","Ethyl pyruvate","f4","L3900-24","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Ethyl pyruvate (CTI-01) is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.",116.12,"617-35-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/ethyl-pyruvate.html","C5H8O3","free base","CTI-01","CCOC(=O)C(C)=O",0.246,3,0,3]
["S6249","Picolinic acid (PCL 016)","g4","L3900-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picolinic acid (PCL 016) is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.",123.11,"98-98-6",24.62,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/picolinic-acid-pcl-016.html","C6H5NO2","free base","N/A","OC(=O)C1=NC=CC=C1",0.737,2,0,1]
["S6257","N-Acetylglucosamine","h4","L3900-24","in 10mM DMSO","Others","Others","N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases.",221.21,"7512-17-6",44.24,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/n-acetylglucosamine.html","C8H15NO6","free base","GlcNAc","CC(=O)NC(C=O)C(O)C(O)C(O)CO",-3.059,2,5,6]
["S6263","Glycerol Tributyrate","a5","L3900-24","in 10mM DMSO","Others","Others","Glycerol tributyrate (Tributyrin) is a triglyceride that may inhibit cell growth and induce cell differentiation.",302.36,"60-01-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/glycerol-tributyrate.html","C15H26O6","free base","Tributyrin","CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC",3.098,6,0,14]
["S6272","Glycolic acid","b5","L3900-24","in 10mM DMSO","Tyrosinase","Proteases","Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.",76.05,"79-14-1",15.21,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/glycolic-acid.html","C2H4O3","free base","dicarbonous acid, hydroxyacetic acid, hydroacetic acid","OCC(O)=O",-0.877,1,1,1]
["S6296","Octanoic acid","c5","L3900-24","in 10mM DMSO","Others","Others","Octanoic acid (caprylic acid) is found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil. It is used in the production of esters used in perfumery and also in the manufacture of dyes.",144.21,"124-07-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/octanoic-acid.html","C8H16O2","free base","caprylic acid","CCCCCCCC(O)=O",2.743,1,0,6]
["S6402","2-Aminoethanethiol","d5","L3900-24","in 10mM DMSO","Others","Others","2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.",77.15,"60-23-1",{"v":15,"d":"15.00"},194.43,{"v":15,"d":"15.00"},194.43,"http://www.selleck.cn/products/2-aminoethanethiol.html","C2H7NS","Free Base","cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine","NCCS",-0.216,0,1,1]
["S6403","Chloramine-T","e5","L3900-24","in 10mM DMSO","Others","Others","Chloramine-T is a N-chlorinated and N-deprotonated sulfonamide used as a biocide and a mild disinfectant.",227.64,"127-65-1",{"v":46,"d":"46.00"},202.07,{"v":46,"d":"46.00"},202.07,"http://www.selleck.cn/products/chloramine-t.html","C7H7ClNNaO2S","Free Base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)N([Na])Cl",1.714,2,0,2]
["S6407","Tulobuterol hydrochloride","f5","L3900-24","in 10mM DMSO","Androgen Receptor","Neuronal Signaling","Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities.",264.19,"56776-01-3",{"v":53,"d":"53.00"},200.61,{"v":53,"d":"53.00"},200.61,"http://www.selleck.cn/products/tulobuterol-hydrochloride.html","C12H19Cl2NO","hydrochloride","N/A","Cl.CC(C)(C)NCC(O)C1=C(Cl)C=CC=C1",2.834,0,2,4]
["S6408","Hexetidine","g5","L3900-24","in 10mM DMSO","Fungal","Microbiology","Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity.",{"v":339.6,"d":"339.60"},"141-94-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/hexetidine.html","C21H45N3","Free Base","N/A","CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1",5.697,0,1,12]
["S6409","Zucapsaicin","h5","L3900-24","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.",305.41,"25775-90-0",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://www.selleck.cn/products/zucapsaicin.html","C18H27NO3","Free Base","N/A","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C/C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S6410","Clemizole","a6","L3900-24","in 10mM DMSO","Dopamine Receptor,TRP Channel","Neuronal Signaling","Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels.",325.84,"442-52-4",{"v":65,"d":"65.00"},199.48,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/clemizole.html","C19H20ClN3","Free Base","N/A","ClC1=CC=C(C[N]2C(=NC3=C2C=CC=C3)CN4CCCC4)C=C1",4.527,1,0,4]
["S6411","Nimorazole","b6","L3900-24","in 10mM DMSO","Bacterial","Microbiology","Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity.",226.23,"6506-37-2",{"v":45,"d":"45.00"},198.91,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/nimorazole.html","C9H14N4O3","Free Base","N/A","[O-][N+](=O)C1=CN=C[N]1CCN2CCOCC2",-0.232,2,0,4]
["S6412","Altiratinib","c6","L3900-24","in 10mM DMSO","c-Met,Tie-2,Trk receptor,VEGFR","Protein Tyrosine Kinase","Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM.",510.46,"1345847-93-9",{"v":100,"d":"100.00"},{"v":195.9,"d":"195.90"},"<1","N/A","http://www.selleck.cn/products/altiratinib.html","C26H21F3N4O4","free base","DCC-2701","FC1=CC=C(NC(=O)C2(CC2)C(=O)NC3=C(F)C=C(OC4=CC(=NC=C4)NC(=O)C5CC5)C(=C3)F)C=C1",3.867,5,3,8]
["S6414","Apilimod (STA-5326)","d6","L3900-24","in 10mM DMSO","Interleukins,PIKfyve","PI3K/Akt/mTOR","Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.",418.49,"541550-19-0",{"v":84,"d":"84.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/apilimod.html","C23H26N6O2","Free Base","STA-5326","CC1=CC=CC(=C1)\\C=N\\NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4",4.485,6,1,8]
["S6415","Azeliragon (TTP488)","e6","L3900-24","in 10mM DMSO","Others","Others","Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD.",532.12,"603148-36-3",{"v":100,"d":"100.00"},187.93,"<1","N/A","http://www.selleck.cn/products/azeliragon.html","C32H38ClN3O2","Free Base","PF-04494700","CCCCC1=NC(=C[N]1C2=CC=C(OC3=CC=C(Cl)C=C3)C=C2)C4=CC=C(OCCCN(CC)CC)C=C4",8.393,3,0,14]
["S6418","PF 429242","f6","L3900-24","in 10mM DMSO","S1P Receptor","GPCR & G Protein","PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM).",409.56,"947303-87-9",{"v":82,"d":"82.00"},200.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/pf429242.html","C25H35N3O2","Free Base","N/A","CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)C3CCNC3",3.415,2,1,10]
["S6419","Omilancor (BT-11)","g6","L3900-24","in 10mM DMSO","Others","Others","Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).",528.56,"1912399-75-7",{"v":13,"d":"13.00"},{"v":24.6,"d":"24.60"},"<1","N/A","http://www.selleck.cn/products/bt-11.html","C30H24N8O2","Free Base","N/A","O=C(N1CCN(CC1)C(=O)C2=NC(=CC=C2)C3=NC4=C([NH]3)C=CC=C4)C5=CC=CC(=N5)C6=NC7=CC=CC=C7[NH]6",4.419,6,2,4]
["S6420","AGI 1067","h6","L3900-24","in 10mM DMSO","Others","Immunology & Inflammation","AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.",616.91,"216167-82-7",{"v":100,"d":"100.00"},{"v":162.1,"d":"162.10"},"<1","N/A","http://www.selleck.cn/products/agi-1067.html","C35H52O5S2","Free Base","N/A","CC(C)(C)C1=C(O)C(=CC(=C1)SC(C)(C)SC2=CC(=C(OC(=O)CCC(O)=O)C(=C2)C(C)(C)C)C(C)(C)C)C(C)(C)C",9.634,3,1,13]
["S6421","Diroximel Fumarate","a7","L3900-24","in 10mM DMSO","Others","Others","Diroximel Fumarate (ALKS-8700) is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body.",255.22,"1577222-14-0",{"v":51,"d":"51.00"},199.83,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/diroximel-fumarete.html","C11H13NO6","Fumarete","ALKS-8700","COC(=O)\\C=C\\C(=O)OCCN1C(=O)CCC1=O",-0.278,6,0,7]
["S6422","Lazabemide","b7","L3900-24","in 10mM DMSO","MAO","Metabolism","Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.",{"v":236.1,"d":"236.10"},"103878-83-7",{"v":40,"d":"40.00"},169.42,{"v":40,"d":"40.00"},169.42,"http://www.selleck.cn/products/lazabemide.html","C8H11Cl2N3O","Free Base","Ro 19-6327","Cl.NCCNC(=O)C1=CC=C(Cl)C=N1",0.533,2,2,3]
["S6424","TAS-301","c7","L3900-24","in 10mM DMSO","PKC","TGF-beta/Smad","TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. TAS-301 inhibits intimal thickening after balloon injury to rat carotid arteries, and inhibits PKC activation induced by PDGF.",{"v":357.4,"d":"357.40"},"193620-69-8",{"v":71,"d":"71.00"},198.66,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/tas-301.html","C23H19NO3","Free Base","N/A","COC1=CC=C(C=C1)C(C2=CC=C(OC)C=C2)=C3C(=O)NC4=C3C=CC=C4",4.176,3,1,4]
["S6432","Cevimeline HCl hemihydrate","d7","L3900-24","in 10mM DMSO","AChR","Metabolism","Cevimeline HCl hemihydrate(AF 102B, SNI 2011, SNK 508) is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3.",244.78,"153504-70-2",{"v":40,"d":"40.00"},169.66,{"v":40,"d":"40.00"},169.66,"https://www.selleckchem.com/products/cevimeline.html","C10H18ClNOS.1/2H2O","HCl hemihydrate","AF 102B, SNI 2011, SNK 508","Cl.CC1OC2(CS1)CN3CCC2CC3",2.151,1,0,0]
["S6433","Udenafil","e7","L3900-24","in 10mM DMSO","PDE","Metabolism","Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs.",516.66,"268203-93-6",{"v":100,"d":"100.00"},193.55,"<1","N/A","http://www.selleck.cn/products/udenafil.html","C25H36N6O4S","Free Base","N/A","CCCOC1=CC=C(C=C1C2=NC(=O)C3=C(N2)C(=N[N]3C)CCC)[S](=O)(=O)NCCC4CCCN4C",3.298,6,2,11]
["S6435","Mequitazine","f7","L3900-24","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Mequitazine (LM-209) is a histamine H1 antagonist which competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.",322.47,"29216-28-2",{"v":32,"d":"32.00"},99.23,"<1","N/A","http://www.selleck.cn/products/mequitazine.html","C20H22N2S","Free Base","LM-209","C1CN2CCC1C(C2)CN3C4=C(SC5=C3C=CC=C5)C=CC=C4",4.409,0,0,2]
["S6439","Talniflumate","g7","L3900-24","in 10mM DMSO","Chloride Channel,Immunology & Inflammation related","Immunology & Inflammation","Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. Talniflumate is also an inhibitor of human calcium-activated chloride channels.",414.33,"66898-62-2",{"v":61,"d":"61.00"},147.23,"<1","N/A","http://www.selleck.cn/products/talniflumate.html","C21H13F3N2O4","Free Base","MSI-1995","FC(F)(F)C1=CC(=CC=C1)NC2=C(C=CC=N2)C(=O)OC3OC(=O)C4=C3C=CC=C4",5.023,5,1,6]
["S6444","Triclocarban","h7","L3900-24","in 10mM DMSO","Bacterial","Microbiology","Triclocarban is an antibacterial agent common used in personal care products.",315.58,"101-20-2",{"v":63,"d":"63.00"},199.63,"<1","N/A","http://www.selleck.cn/products/triclocarban.html","C13H9Cl3N2O","Free Base","N/A","ClC1=CC=C(NC(=O)NC2=CC=C(Cl)C(=C2)Cl)C=C1",4.516,1,2,2]
["S6452","Delavirdine mesylate","a8","L3900-24","in 10mM DMSO","Reverse Transcriptase","Microbiology","Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.",552.67,"147221-93-0",{"v":100,"d":"100.00"},180.94,"<1","N/A","http://www.selleck.cn/products/delavirdine.html","C23H32N6O6S2","mesylate","U 90152 mesylate","CC(C)NC1=CC=CN=C1N2CCN(CC2)C(=O)C3=CC4=C([NH]3)C=CC(=C4)N[S](C)(=O)=O.C[S](O)(=O)=O",1.879,4,3,6]
["S6453","Bicyclol","b8","L3900-24","in 10mM DMSO","HBV","Microbiology","Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.",390.34,"118159-48-1",{"v":78,"d":"78.00"},199.83,"<1","N/A","http://www.selleck.cn/products/bicyclol.html","C19H18O9","Free Base","SY-801","COC(=O)C1=CC(=C2OCOC2=C1C3=C4OCOC4=C(OC)C=C3CO)OC",2.102,8,1,6]
["S6454","Docosahexaenoic Acid","c8","L3900-24","in 10mM DMSO","Others","Others","Docosahexaenoic Acid (DHA, Cervonic acid, Doconexent) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults.",328.49,"6217-54-5",{"v":66,"d":"66.00"},200.92,{"v":8,"d":"8.00"},24.35,"http://www.selleck.cn/products/docosahexaenoic-acid.html","C22H32O2","Free Base","DHA, Cervonic acid, Doconexent","CC\\C=C/C/C=C\\C\\C=C/C/C=C\\C\\C=C/C/C=C\\CCC(O)=O",6.462,1,0,14]
["S6459","Nifurtimox","d8","L3900-24","in 10mM DMSO","Anti-infection","Microbiology","Nifurtimox (BAY-2502) is an antiprotozoal agent.",287.29,"23256-30-6",{"v":57,"d":"57.00"},198.41,"<1","N/A","http://www.selleck.cn/products/nifurtimox.html","C10H13N3O5S","Free Base","BAY-2502","CC1C[S](=O)(=O)CCN1\\N=C\\C2=CC=C(O2)[N+]([O-])=O",0.772,4,0,3]
["S6461","Permethrin","e8","L3900-24","in 10mM DMSO","Anti-infection","Microbiology","Permethrin(NRDC-143) is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths.",391.29,"52645-53-1",{"v":78,"d":"78.00"},199.34,"<1","N/A","http://www.selleck.cn/products/permethrin.html","C21H20Cl2O3","Free Base","NRDC-143","CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC2=CC(=CC=C2)OC3=CC=CC=C3",5.438,3,0,7]
["S6465","Tafamidis","f8","L3900-24","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs.",308.12,"594839-88-0",{"v":31,"d":"31.00"},100.61,"<1","N/A","http://www.selleck.cn/products/tafamidis.html","C14H7Cl2NO3","Free Base","N/A","OC(=O)C1=CC=C2N=C(OC2=C1)C3=CC(=CC(=C3)Cl)Cl",4.239,3,0,2]
["S6467","Fosfluconazole","g8","L3900-24","in 10mM DMSO","Fungal","Microbiology","Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.",386.25,"194798-83-9",{"v":19,"d":"19.00"},49.19,"<1","N/A","http://www.selleck.cn/products/fosfluconazole.html","C13H13F2N6O4P","Free Base","N/A","O[P](O)(=O)OC(C[N]1C=NC=N1)(C[N]2C=NC=N2)C3=C(F)C=C(F)C=C3",0.678,5,0,7]
["S6468","Trandolapril","h8","L3900-24","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.",430.54,"87679-37-6",{"v":86,"d":"86.00"},199.75,"<1","N/A","http://www.selleck.cn/products/trandolapril.html","C24H34N2O5","Free Base","RU44570","CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(O)=O",0.764,4,1,10]
["S6471","Lucanthone","a9","L3900-24","in 10mM DMSO","Autophagy","Autophagy","Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.",340.48,"479-50-5",{"v":33,"d":"33.00"},96.92,"<1","N/A","http://www.selleck.cn/products/lucanthone.html","C20H24N2OS","Free Base","N/A","CCN(CC)CCNC1=CC=C(C)C2=C1C(=O)C3=C(S2)C=CC=C3",4.653,1,1,6]
["S6472","Tinoridine hydrochloride","b9","L3900-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.",352.88,"25913-34-2",{"v":18,"d":"18.00"},51.01,"<1","N/A","http://www.selleck.cn/products/tinoridine-hydrochloride.html","C17H21ClN2O2S","hydrochloride","Y-3642 HCl","Cl.CCOC(=O)C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2",3.265,2,1,5]
["S6476","Eicosapentaenoic Acid","c9","L3900-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid with antiinflammatory properties, and is present in fish and fish oils, including salmon, cod, and krill oils.",302.45,"10417-94-4",{"v":60,"d":"60.00"},198.38,"<1","N/A","http://www.selleck.cn/products/eicosapentaenoic-acid.html","C20H30O2","Free Base","N/A","CC/C=C\\C\\C=C/C/C=C\\C\\C=C/C/C=C\\CCCC(O)=O",5.994,1,0,13]
["S6484","uridine triacetate","d9","L3900-24","in 10mM DMSO","Others","Others","Uridine triacetate (Vistonuridine, PN401) is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity.",370.31,"4105-38-8",{"v":74,"d":"74.00"},199.83,{"v":7,"d":"7.00"},{"v":18.9,"d":"18.90"},"http://www.selleck.cn/products/uridine-triacetate.html","C15H18N2O9","triacetate","Vistonuridine, PN401","CC(=O)OCC1OC(C(OC(C)=O)C1OC(C)=O)N2C=CC(=O)NC2=O",-1.314,9,1,8]
["S6487","fluticasone furoate","e9","L3900-24","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fluticasone furoate (GW685698) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.",538.58,"397864-44-7",{"v":100,"d":"100.00"},185.67,"<1","N/A","http://www.selleck.cn/products/fluticasone-furoate.html","C27H29F3O6S","free base","GW685698","CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(OC(=O)C5=CC=CO5)C(=O)SCF",4.479,5,1,6]
["S6492","Doravirine (MK-1439)","f9","L3900-24","in 10mM DMSO","Reverse Transcriptase","Microbiology","Doravirine (MK-1439) is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.",425.75,"1338225-97-0",{"v":85,"d":"85.00"},199.65,"<1","N/A","http://www.selleck.cn/products/doravirine-mk-1439.html","C17H11C1F3N5O3","free base","N/A","CN1C(=O)NN=C1CN2C=CC(=C(OC3=CC(=CC(=C3)C#N)Cl)C2=O)C(F)(F)F",1.694,4,1,5]
["S6505","X-376","g9","L3900-24","in 10mM DMSO","ALK","Angiogenesis","X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer.",547.41,"1365267-27-1",{"v":100,"d":"100.00"},182.68,"<1","N/A","http://www.selleck.cn/products/x-376.html","C25H25Cl2FN6O3","free base","N/A","CC(OC1=CC(=NN=C1N)C(=O)NC2=CC=C(C=C2)C(=O)N3CCN(C)CC3)C4=C(Cl)C=CC(=C4Cl)F",4.067,5,2,6]
["S6508","Mitapivat","h9","L3900-24","in 10mM DMSO","PKM","Metabolism","Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.",450.55,"1260075-17-9",{"v":90,"d":"90.00"},199.76,"<1","N/A","http://www.selleck.cn/products/mitapivat.html","C24H26N4O3S","free base","AG-348","O=C(N1CCN(CC1)CC2CC2)C3=CC=C(N[S](=O)(=O)C4=C5N=CC=CC5=CC=C4)C=C3",2.695,4,1,6]
["S6519","R112","a10","L3900-24","in 10mM DMSO","Syk","Angiogenesis","R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor with Ki value of 96 nM.",{"v":312.3,"d":"312.30"},"575474-82-7",{"v":62,"d":"62.00"},198.53,"<1","N/A","http://www.selleck.cn/products/r112.html","C16H13FN4O2","free base","N/A","OC1=CC=CC(=C1)NC2=NC=C(F)C(=N2)NC3=CC(=CC=C3)O",3.933,2,4,4]
["S6520","WHI-P180","b10","L3900-24","in 10mM DMSO","c-RET,VEGFR","Protein Tyrosine Kinase","WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET (c-RET) and kinase insert domain receptor (KDR), respectively.",297.31,"211555-08-7",{"v":59,"d":"59.00"},198.45,"<1","N/A","http://www.selleck.cn/products/whi-p180.html","C16H15N3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC(=CC=C3)O",3.202,4,2,4]
["S6523","RG14620","c10","L3900-24","in 10mM DMSO","BCRP,EGFR","Protein Tyrosine Kinase","RG14620 (Tyrphostin RG14620), an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2/BCRP.",275.13,"136831-49-7",{"v":55,"d":"55.00"},199.91,"<1","N/A","http://www.selleck.cn/products/rg14620.html","C14H8Cl2N2","free base","Tyrphostin RG14620","ClC1=CC(=CC(=C1)Cl)\\C=C(C#N)/C2=CC=CN=C2",3.833,1,0,2]
["S6533","Briciclib","d10","L3900-24","in 10mM DMSO","eIF","ER stress & UPR","Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).",474.42,"865783-99-9",{"v":95,"d":"95.00"},200.24,"<1","N/A","http://www.selleck.cn/products/briciclib.html","C19H23O10PS","free base","ON-014185","COC1=CC(=C(/C=C/[S](=O)(=O)CC2=CC=C(OC)C(=C2)O[P](O)(O)=O)C(=C1)OC)OC",2.319,7,0,10]
["S6537","CVT-313","e10","L3900-24","in 10mM DMSO","CDK","Autophagy","CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases.",400.47,"199986-75-9",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://www.selleck.cn/products/cvt-313.html","C20H28N6O3","free base","N/A","COC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3C(C)C)N(CCO)CCO)C=C1",2.217,4,3,10]
["S6541","MTX-211","f10","L3900-24","in 10mM DMSO","EGFR,PI3K","Protein Tyrosine Kinase","MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase.",478.33,"1952236-05-3",{"v":24,"d":"24.00"},50.17,"<1","N/A","http://www.selleck.cn/products/mtx-211.html","C20H14Cl2FN5O2S","free base","N/A","C[S](=O)(=O)NC1=CC(=CN=C1Cl)C2=CC3=C(NC4=CC=C(F)C(=C4)Cl)N=CN=C3C=C2",4.499,5,2,5]
["S6543","ZD-4190","g10","L3900-24","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively.",459.27,"413599-62-9",{"v":12,"d":"12.00"},26.13,"<1","N/A","http://www.selleck.cn/products/zd-4190.html","C19H16BrFN6O2","free base","N/A","COC1=CC2=C(NC3=CC=C(Br)C=C3F)N=CN=C2C=C1OCC[N]4C=CN=N4",4.229,6,1,7]
["S6555","AZD2098","h10","L3900-24","in 10mM DMSO","CCR","Immunology & Inflammation","AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.",334.18,"566203-88-1",{"v":67,"d":"67.00"},200.49,"<1","N/A","http://www.selleck.cn/products/azd2098.html","C11H9Cl2N3O3S","free base","N/A","COC1=NC=CN=C1N[S](=O)(=O)C2=C(Cl)C(=CC=C2)Cl",2.407,5,1,4]
["S6610","GSK2981278","a11","L3900-24","in 10mM DMSO","ROR","Transmembrane Transporters","GSK2981278 is a highly potent and selective inverse agonist for RORγ.",461.61,"1474110-21-8",{"v":92,"d":"92.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://www.selleck.cn/products/gsk2981278.html","C25H35NO5S","free base","N/A","CCC1=CC=C(C=C1)N(CC(C)C)[S](=O)(=O)C2=CC=C(OCC3CCOCC3)C(=C2)CO",4.456,4,1,10]
["S7007","Binimetinib (MEK162)","b11","L3900-24","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.",441.23,"606143-89-9",{"v":88,"d":"88.00"},199.44,"<1","N/A","http://selleckchem.com/products/mek162.html","C17H15BrF2N4O3","free base","ARRY-162,ARRY-438162","C[N]1C=NC2=C1C=C(C(=O)NOCCO)C(=C2F)NC3=C(F)C=C(Br)C=C3",2.775,3,3,6]
["S7009","LCL161","c11","L3900-24","in 10mM DMSO","IAP,Mitochondrial Metabolism","Apoptosis","LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).",500.63,"1005342-46-0",{"v":100,"d":"100.00"},199.75,"<1","N/A","http://selleckchem.com/products/lcl161.html","C26H33FN4O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(F)C=C4",3.785,4,2,8]
["S7010","GDC-0152","d11","L3900-24","in 10mM DMSO","IAP","Apoptosis","GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.",498.64,"873652-48-3",{"v":99,"d":"99.00"},198.54,{"v":3,"d":"3.00"},6.02,"http://selleckchem.com/products/gdc-0152.html","C25H34N6O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4",2.767,5,3,8]
["S7014","Merestinib (LY2801653)","e11","L3900-24","in 10mM DMSO","Axl,c-Met,DDR,FLT3,Mertk,ROS1","Protein Tyrosine Kinase","Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.",552.53,"1206799-15-6",{"v":100,"d":"100.00"},180.99,"<1","N/A","http://selleckchem.com/products/ly2801653-merestinib.html","C30H22F2N6O3","free base","N/A","C[N]1N=CC2=CC(=C(C=C12)C3=C[NH]N=C3)OC4=C(F)C=C(NC(=O)C5=CC=C(C)N(C5=O)C6=CC=C(F)C=C6)C=C4",{"v":4.5,"d":"4.500"},5,2,6]
["S7015","Birinapant (TL32711)","f11","L3900-24","in 10mM DMSO","Apoptosis related,HIV,IAP","Apoptosis","Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.",806.94,"1260251-31-7",{"v":100,"d":"100.00"},123.92,"<1","N/A","http://selleckchem.com/products/birinapant-tl32711.html","C42H56F2N8O6","free base","TL32711","CCC(NC(=O)C(C)NC)C(=O)N1CC(O)CC1CC2=C([NH]C3=C2C=CC(=C3)F)C4=C(CC5CC(O)CN5C(=O)C(CC)NC(=O)C(C)NC)C6=C([NH]4)C=C(F)C=C6",{"v":3.08,"d":"3.080"},4,8,15]
["S7016","VS-5584 (SB2343)","g11","L3900-24","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.",354.41,"1246560-33-7",{"v":71,"d":"71.00"},200.33,"<1","N/A","http://selleckchem.com/products/vs-5584-sb2343.html","C17H22N8O","free base","N/A","CC(C)[N]1C(=NC2=C1N=C(N=C2C3=CN=C(N)N=C3)N4CCOCC4)C",1.272,6,1,3]
["S7025","Embelin","h11","L3900-24","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,IAP","Apoptosis","Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.",294.39,"550-24-3",{"v":59,"d":"59.00"},200.41,"<1","N/A","http://selleckchem.com/products/embelin.html","C17H26O4","free base","Embelic Acid, NSC 91874","CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O",{"v":4.62,"d":"4.620"},2,2,10]
["S7028","Duvelisib (IPI-145)","a2","L3900-25","in 10mM DMSO","PI3K","Angiogenesis","Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.",416.86,"1201438-56-3",{"v":83,"d":"83.00"},199.11,"<1","N/A","http://selleckchem.com/products/ipi-145-ink1197.html","C22H17ClN6O","free base","INK1197","CC(NC1=NC=NC2=C1N=C[NH]2)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)Cl",3.648,4,2,4]
["S7029","AZD2461","b2","L3900-25","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.",395.43,"1174043-16-3",{"v":79,"d":"79.00"},199.78,"<1","N/A","http://selleckchem.com/products/azd2461.html","C22H22FN3O3","free base","N/A","COC1CCN(CC1)C(=O)C2=CC(=CC=C2F)CC3=NNC(=O)C4=CC=CC=C34",1.993,4,1,4]
["S7030","RG-7112","c2","L3900-25","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7036","XL019","d2","L3900-25","in 10mM DMSO","JAK","JAK/STAT","XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.",444.53,"945755-56-6",{"v":16,"d":"16.00"},35.99,"<1","N/A","http://selleckchem.com/products/xl019.html","C25H28N6O2","free base","N/A","O=C(NC1=CC=C(C=C1)C2=CC=NC(=N2)NC3=CC=C(C=C3)N4CCOCC4)C5CCCN5",3.106,4,3,6]
["S7039","PD168393","e2","L3900-25","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.",369.22,"194423-15-9",{"v":73,"d":"73.00"},197.71,"<1","N/A","http://selleckchem.com/products/pd168393.html","C17H13BrN4O","free base","N/A","BrC1=CC(=CC=C1)NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23",4.043,3,2,4]
["S7040","AZD3514","f2","L3900-25","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.",519.56,"1240299-33-5",{"v":100,"d":"100.00"},192.47,"<1","N/A","http://selleckchem.com/products/azd3514.html","C25H32F3N7O2","free base","N/A","CC(=O)N1CCN(CCOC2=CC=C(C=C2)C3CCN(CC3)C4=N[N]5C(=NN=C5C(F)(F)F)CC4)CC1",2.235,5,0,7]
["S7041","CX-6258 HCl","g2","L3900-25","in 10mM DMSO","Pim","JAK/STAT","CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.",{"v":498.4,"d":"498.40"},"1353859-00-3",{"v":57,"d":"57.00"},114.37,{"v":89,"d":"89.00"},178.57,"http://selleckchem.com/products/CX-6258.html","C26H24ClN3O3.HCl","Hydrochloride","N/A","Cl.CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)\\C=C4\\C(=O)NC5=C4C=C(Cl)C=C5",4.416,3,1,3]
["S7046","Brefeldin A","h2","L3900-25","in 10mM DMSO","Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy","Transmembrane Transporters","Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.",280.36,"20350-15-6",{"v":4,"d":"4.00"},14.27,"<1","N/A","http://selleckchem.com/products/brefeldin-a.html","C16H24O4","free base","BFA, Cyanein, Decumbin","CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1",2.152,2,2,0]
["S7049","Oprozomib (ONX 0912)","a3","L3900-25","in 10mM DMSO","Proteasome","Proteases","Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.",532.61,"935888-69-0",{"v":100,"d":"100.00"},187.75,"<1","N/A","http://selleckchem.com/products/oprozomib-onx-0912.html","C25H32N4O7S","free base","PR-047","COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3",-0.202,8,3,14]
["S7057","LY2874455","b3","L3900-25","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.",444.31,"1254473-64-7",{"v":88,"d":"88.00"},198.06,"<1","N/A","http://selleckchem.com/products/ly2874455.html","C21H19Cl2N5O2","free base","N/A","CC(OC1=CC=C2[NH]N=C(\\C=C\\C3=C[N](CCO)N=C3)C2=C1)C4=C(Cl)C=NC=C4Cl",4.121,4,2,7]
["S7059","Tezacaftor (VX-661)","c3","L3900-25","in 10mM DMSO","CFTR","Transmembrane Transporters","Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.",{"v":520.5,"d":"520.50"},"1152311-62-0",{"v":100,"d":"100.00"},192.12,"<1","N/A","http://selleckchem.com/products/vx-661.html","C26H27F3N2O6","free base","N/A","CC(C)(CO)C1=CC2=CC(=C(F)C=C2[N]1CC(O)CO)NC(=O)C3(CC3)C4=CC=C5OC(F)(F)OC5=C4",5.215,3,4,8]
["S7063","LY2090314","d3","L3900-25","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.",512.53,"603288-22-8",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/ly2090314.html","C28H25FN6O3","free base","N/A","FC1=CC2=C3[N](CCN(C2)C(=O)N4CCCCC4)C=C(C3=C1)C5=C(C(=O)NC5=O)C6=CN=C7C=CC=C[N]67",2.707,4,1,2]
["S7067","Tepotinib (EMD 1214063)","e3","L3900-25","in 10mM DMSO","Autophagy,c-Met","Protein Tyrosine Kinase","Tepotinib (EMD 1214063, MSC2156119) is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib (EMD 1214063) induces autophagy. Phase 1.",492.57,"1100598-32-0",{"v":5,"d":"5.00"},10.15,"<1","N/A","http://selleckchem.com/products/emd-1214063.html","C29H28N6O2","free base","MSC2156119","CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4N=C(C=CC4=O)C5=CC(=CC=C5)C#N",3.629,5,0,7]
["S7076","T0901317","f3","L3900-25","in 10mM DMSO","Apoptosis related,FXR,Liver X Receptor,ROR","Metabolism","T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of 20nM for LXRα and 5 μM for FXR, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.",481.33,"293754-55-9",{"v":96,"d":"96.00"},199.45,"<1","N/A","http://selleckchem.com/products/t0901317.html","C17H12F9NO3S","free base","N/A","OC(C1=CC=C(C=C1)N(CC(F)(F)F)[S](=O)(=O)C2=CC=CC=C2)(C(F)(F)F)C(F)(F)F",4.826,2,0,8]
["S7077","Cilengitide trifluoroacetate","g3","L3900-25","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.",702.68,"199807-35-7",{"v":100,"d":"100.00"},142.31,{"v":8,"d":"8.00"},11.38,"http://selleckchem.com/products/cilengitide-emd-121974-nsc-707544.html","C29H41F3N8O9","Trifluoroacetat","EMD 121974, NSC 707544","CC(C)C1N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O.OC(=O)C(F)(F)F",-0.565,7,6,11]
["S7083","Ceritinib (LDK378)","h3","L3900-25","in 10mM DMSO","ALK,FLT3,IGF-1R,Serine/threonin kinase","Protein Tyrosine Kinase","Ceritinib (LDK378) is a potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays. Ceritinib (LDK378) also inhibits IGF-1R, InsR, STK22D and FLT3 with IC50 of 8 nM, 7 nM, 23 nM and 60 nM, respectively. Phase 3.",558.14,"1032900-25-6",{"v":20,"d":"20.00"},35.83,"<1","N/A","http://selleckchem.com/products/ldk378.html","C28H36ClN5O3S","free base","N/A","CC(C)OC1=C(NC2=NC(=C(Cl)C=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4",6.479,5,3,9]
["S7090","GSK923295","a4","L3900-25","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.",592.13,"1088965-37-0",{"v":100,"d":"100.00"},168.88,"<1","N/A","http://selleckchem.com/products/gsk923295.html","C32H38ClN5O4","free base","N/A","CC(C)OC1=CC=C(C=C1Cl)C(=O)NC(CNC(=O)CN(C)C)CC2=CC=C(C=C2)C3=C[N]4C=CC=C(C(C)O)C4=N3",4.004,4,3,12]
["S7091","Zotarolimus (ABT-578)","b4","L3900-25","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Zotarolimus (ABT-578,A 179578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.",966.21,"221877-54-9",{"v":100,"d":"100.00"},{"v":103.5,"d":"103.50"},"<1","N/A","http://selleckchem.com/products/zotarolimus-abt-578.html","C52H79N5O12","free base","A 179578","COC1CC(CCC1[N]2C=NN=N2)CC(C)C3CC(=O)C(C)/C=C(C)/C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC4CCC(C)C(O)(O4)C(=O)C(=O)N5CCCCC5C(=O)O3)OC",5.793,13,1,7]
["S7094","PF-3758309","c4","L3900-25","in 10mM DMSO","Apoptosis related,PAK","Cytoskeletal Signaling","PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4  with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.",490.62,"898044-15-0",{"v":98,"d":"98.00"},199.75,"<1","N/A","http://selleckchem.com/products/pf-3758309.html","C25H30N8OS","free base","PF-03758309","CN(C)CC(NC(=O)N1CC2=C([NH]N=C2NC3=NC(=NC4=C3SC=C4)C)C1(C)C)C5=CC=CC=C5",4.077,4,3,6]
["S7097","HSP990 (NVP-HSP990)","d4","L3900-25","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","HSP990 (NVP-HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM. NVP-HSP990 induces cell cycle arrest and apoptosis.",379.39,"934343-74-5",{"v":75,"d":"75.00"},197.69,"<1","N/A","http://selleckchem.com/products/hsp990-nvp-hsp990.html","C20H18FN5O2","free base","N/A","COC1=NC(=CC=C1)C2=C(C=CC(=C2)F)C3CC4=C(C(=NC(=N4)N)C)C(=O)N3",2.669,5,2,3]
["S7098","PD123319","e4","L3900-25","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.",508.61,"130663-39-7",{"v":100,"d":"100.00"},196.61,{"v":100,"d":"100.00"},196.61,"http://selleckchem.com/products/pd123319.html","C31H32N4O3","free base","N/A","CN(C)C1=C(C)C=C(C[N]2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(O)=O)C=C1",4.593,3,0,7]
["S7102","Berzosertib (VE-822)","f4","L3900-25","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.",463.55,"1232416-25-9",{"v":36,"d":"36.00"},77.66,"<1","N/A","http://selleckchem.com/products/ve-822.html","C24H25N5O3S","free base","VX970, M6620","CNCC1=CC=C(C=C1)C2=NOC(=C2)C3=C(N)N=CC(=N3)C4=CC=C(C=C4)[S](=O)(=O)C(C)C",3.697,6,2,7]
["S7103","Taselisib (GDC 0032)","g4","L3900-25","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Taselisib (GDC 0032, RG7604) is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.",460.53,"1282512-48-4",{"v":70,"d":"70.00"},{"v":152,"d":"152.00"},"<1","N/A","http://selleckchem.com/products/gdc-0032.html","C24H28N8O2","free base","RG7604","CC(C)[N]1N=C(C)N=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)C5=C[N](N=C5)C(C)(C)C(N)=O",{"v":2.47,"d":"2.470"},6,1,5]
["S7104","AZD1208","h4","L3900-25","in 10mM DMSO","Apoptosis related,Autophagy,Pim","JAK/STAT","AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.",379.48,"1204144-28-4",{"v":75,"d":"75.00"},197.64,"<1","N/A","http://selleckchem.com/products/azd-1208.html","C21H21N3O2S","free base","N/A","NC1CCCN(C1)C2=C(C=CC=C2C3=CC=CC=C3)\\C=C\\4SC(=O)NC4=O",3.283,2,2,3]
["S7110","(+)-JQ1","a5","L3900-25","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1","N/A","http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7111","IDO-IN-2","b5","L3900-25","in 10mM DMSO","IDO/TDO","Metabolism","IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue) is a a potent IDO1 inhibitor with IC50 of 38 nM.",282.38,"1402836-58-1",{"v":15,"d":"15.00"},53.12,"<1","N/A","http://selleckchem.com/products/nlg919.html","C18H22N2O","free base","RG 6078, NLG-919 analogue, GDC-0919 analogue","OC(CC1[N]2C=NC=C2C3=C1C=CC=C3)C4CCCCC4",3.255,1,1,3]
["S7113","Zebularine (NSC 309132)","c5","L3900-25","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay.",{"v":228.2,"d":"228.20"},"3690-10-6",{"v":46,"d":"46.00"},201.58,{"v":46,"d":"46.00"},201.58,"http://selleckchem.com/products/zebularine.html","C9H12N2O5","free base","4-Deoxyuridine","OCC1OC(C(O)C1O)N2C=CC=NC2=O",-1.747,3,3,2]
["S7114","NU6027","d5","L3900-25","in 10mM DMSO","CDK","Cell Cycle","NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.",251.28,"220036-08-8",{"v":50,"d":"50.00"},198.98,"<1","N/A","http://selleckchem.com/products/nu6027.html","C11H17N5O2","free base","N/A","NC1=NC(=C(N=O)C(=N1)OCC2CCCCC2)N",2.576,4,2,4]
["S7115","AMG-517","e5","L3900-25","in 10mM DMSO","TRP Channel","Transmembrane Transporters","AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.",{"v":430.4,"d":"430.40"},"659730-32-2",{"v":86,"d":"86.00"},199.81,"<1","N/A","http://selleckchem.com/products/amg-517.html","C20H13F3N4O2S","free base","N/A","CC(=O)NC1=NC2=C(S1)C=CC=C2OC3=CC(=NC=N3)C4=CC=C(C=C4)C(F)(F)F",4.785,5,1,5]
["S7119","Go6976","f5","L3900-25","in 10mM DMSO","FLT3,JAK,PKC","TGF-beta/Smad","Go6976 (PD406976) is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.",377.42,"136194-77-9",{"v":18,"d":"18.00"},47.69,"<1","N/A","http://selleckchem.com/products/go6976.html","C24H18N4O","free base","PD406976","C[N]1C2=C(C=CC=C2)C3=C1C4=C(C5=C3C(=O)NC5)C6=C(C=CC=C6)[N]4CCC#N",4.168,1,1,2]
["S7121","Tovorafenib (MLN2480)","g5","L3900-25","in 10mM DMSO","Raf","MAPK","Tovorafenib (MLN2480, BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101) is an oral, selective pan-Raf kinase inhibitor in chinical trials.",506.29,"1096708-71-2",{"v":100,"d":"100.00"},197.52,"<1","N/A","http://selleckchem.com/products/mln2480.html","C17H12Cl2F3N7O2S","free base","BIIB-024, TAK580, AMG-2112819, BSK1369, DAY-101","CC(NC(=O)C1=C(Cl)C(=NC=N1)N)C2=NC=C(S2)C(=O)NC3=NC=C(Cl)C(=C3)C(F)(F)F",2.932,6,3,6]
["S7122","XL888","h5","L3900-25","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1.",503.64,"1149705-71-4",{"v":100,"d":"100.00"},198.55,"<1","N/A","http://selleckchem.com/products/xl888.html","C29H37N5O3","free base","N/A","CCC(C)NC1=C(C=C(C)C(=C1)C(=O)NC2CC3CCC(C2)N3C4=NC=C(C=C4)C(=O)C5CC5)C(N)=O",3.772,4,3,9]
["S7125","KPT-185","a6","L3900-25","in 10mM DMSO","CRM1","Transmembrane Transporters","KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.",355.31,"1333151-73-7",{"v":71,"d":"71.00"},199.83,"<1","N/A","http://selleckchem.com/products/kpt-185.html","C16H16F3N3O3","free base","N/A","COC1=CC(=CC(=C1)C(F)(F)F)C2=N[N](\\C=C/C(=O)OC(C)C)C=N2",2.923,5,0,7]
["S7132","P5091 (P005091)","b6","L3900-25","in 10mM DMSO","DUB","Ubiquitin","P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.",348.22,"882257-11-6",{"v":28,"d":"28.00"},80.41,"<1","N/A","http://selleckchem.com/products/p5091-p005091.html","C12H7Cl2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=CC(=C2Cl)Cl)[N+]([O-])=O",4.989,1,0,4]
["S7138","BMS-833923","c6","L3900-25","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.",473.57,"1059734-66-5",{"v":95,"d":"95.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/bms-833923.html","C30H27N5O","free base","XL139","CNCC1=CC(=C(C)C=C1)NC(=O)C2=CC=C(NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5)C=C2",6.214,3,3,7]
["S7143","LGK-974","d6","L3900-25","in 10mM DMSO","PORCN","Stem Cells & Wnt","LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.",396.44,"1243244-14-5",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://selleckchem.com/products/lgk-974.html","C23H20N6O","free base","NVP-LGK974, WNT974","CC1=CC(=CC=N1)C2=C(C)C=C(CC(=O)NC3=CC=C(C=N3)C4=CN=CC=N4)C=N2",2.098,6,1,5]
["S7144","BMS-911543","e6","L3900-25","in 10mM DMSO","JAK","JAK/STAT","BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.",432.52,"1271022-90-2",{"v":36,"d":"36.00"},83.23,"<1","N/A","http://selleckchem.com/products/bms-911543.html","C23H28N8O","free base","N/A","CC[N]1C(=CC2=C1N=C(NC3=N[N](C)C(=C3)C)C4=C2[N](C)C=N4)C(=O)N(C5CC5)C6CC6",3.556,4,1,6]
["S7145","AZD1080","f6","L3900-25","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.",334.37,"612487-72-6",{"v":52,"d":"52.00"},155.52,"<1","N/A","http://selleckchem.com/products/azd1080.html","C19H18N4O2","free base","N/A","OC1=C(C2=CC=C(CN3CCOCC3)C=N2)C4=CC(=CC=C4[NH]1)C#N",2.442,2,2,3]
["S7155","Batimastat (BB-94)","g6","L3900-25","in 10mM DMSO","MMP","Proteases","Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.",477.64,"130370-60-4",{"v":96,"d":"96.00"},200.99,"<1","N/A","http://selleckchem.com/products/bb-94.html","C23H31N3O4S2","free base","N/A","CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)C(CSC2=CC=CS2)C(=O)NO",3.218,3,3,12]
["S7156","Marimastat (BB-2516)","h6","L3900-25","in 10mM DMSO","MMP","Proteases","Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.",331.41,"154039-60-8",{"v":54,"d":"54.00"},162.94,"<1","N/A","http://selleckchem.com/products/marimastat.html","C15H29N3O5","free base","TA2516","CNC(=O)C(NC(=O)C(CC(C)C)C(O)C(=O)NO)C(C)(C)C",0.239,3,4,8]
["S7157","Ilomastat","a7","L3900-25","in 10mM DMSO","MMP","Proteases","Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.",388.46,"142880-36-2",{"v":78,"d":"78.00"},200.79,"<1","N/A","http://selleckchem.com/products/gm6001.html","C20H28N4O4","free base","GM6001, Galardin","CNC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CC(C)C)CC(=O)NO",1.624,3,4,9]
["S7158","Abemaciclib mesylate (LY2835219)","b7","L3900-25","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.",{"v":602.7,"d":"602.70"},"1231930-82-7",{"v":83,"d":"83.00"},137.71,{"v":100,"d":"100.00"},165.92,"http://selleckchem.com/products/ly2835219.html","C27H32F2N8.CH4O3S","mesylate","N/A","CCN1CCN(CC1)CC2=CC=C(NC3=NC(=C(F)C=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)N=C2.C[S](O)(=O)=O",4.543,4,1,7]
["S7160","Glasdegib (PF-04449913)","c7","L3900-25","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.",374.44,"1095173-27-5",{"v":47,"d":"47.00"},125.52,"<1","N/A","http://selleckchem.com/products/glasdegib-pf-04449913.html","C21H22N6O","Free Base","N/A","CN1CCC(CC1C2=NC3=CC=CC=C3[NH]2)NC(=O)NC4=CC=C(C=C4)C#N",2.363,2,3,3]
["S7161","Motolimod (VTX-2337)","d7","L3900-25","in 10mM DMSO","TLR","Immunology & Inflammation","Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2.",{"v":458.6,"d":"458.60"},"926927-61-9",{"v":55,"d":"55.00"},119.93,"<1","N/A","http://selleckchem.com/products/motolimod-vtx-2337.html","C28H34N4O2","free base","N/A","CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(N)C1",3.854,3,1,7]
["S7169","Crenigacestat (LY3039478)","e7","L3900-25","in 10mM DMSO","Gamma-secretase,Notch","Stem Cells & Wnt","Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.",464.44,"1421438-81-4",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/ly3039478.html","C22H23F3N4O4","free base","N/A","CC(NC(=O)CCC(F)(F)F)C(=O)NC1C(=O)N(CCO)C2=C(C=CC=N2)C3=C1C=CC=C3",1.395,4,3,8]
["S7170","Avutometinib","f7","L3900-25","in 10mM DMSO","MEK,Raf","MAPK","Avutometinib(RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.",471.46,"946128-88-7",{"v":94,"d":"94.00"},199.38,"<1","N/A","http://selleckchem.com/products/ro5126766-ch5126766.html","C21H18FN5O5S","free base","RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304","CN[S](=O)(=O)NC1=NC=CC(=C1F)CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O",2.473,8,2,7]
["S7171","Setanaxib (GKT137831)","g7","L3900-25","in 10mM DMSO","Ferroptosis,NADPH-oxidase,ROS","Immunology & Inflammation","Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.",394.85,"1218942-37-0",{"v":78,"d":"78.00"},197.54,"<1","N/A","http://selleckchem.com/products/gkt137831.html","C21H19ClN4O2","free base","GKT831","CN(C)C1=CC=CC(=C1)C2=C3C(=O)N(NC3=CC(=O)N2C)C4=CC=CC=C4Cl",2.366,2,1,3]
["S7173","Spebrutinib (CC-292)","h7","L3900-25","in 10mM DMSO","BTK","Angiogenesis","Spebrutinib (CC-292, AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.",423.44,"1202757-89-8",{"v":85,"d":"85.00"},200.74,"<1","N/A","http://selleckchem.com/products/avl-292.html","C22H22FN5O3","free base","AVL-292","COCCOC1=CC=C(NC2=NC=C(F)C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)C=C1",4.087,5,3,10]
["S7174","Opaganib (ABC294640)","a8","L3900-25","in 10mM DMSO","SPHK","Immunology & Inflammation","Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.",380.91,"915385-81-8",{"v":76,"d":"76.00"},199.52,"<1","N/A","http://selleckchem.com/products/abc294640.html","C23H25ClN2O","free base","N/A","ClC1=CC=C(C=C1)[C]23CC4[CH2]C(C[C](C4)(C2)C(=O)NCC5=CC=NC=C5)C3",4.265,2,1,4]
["S7179","Siponimod (BAF312)","b8","L3900-25","in 10mM DMSO","S1P Receptor","GPCR & G Protein","BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.",{"v":516.6,"d":"516.60"},"1230487-00-9",{"v":100,"d":"100.00"},193.57,"<1","N/A","http://selleckchem.com/products/baf312-siponimod.html","C29H35F3N2O3","free base","N/A","CCC1=CC(=CC=C1CN2CC(C2)C(O)=O)\\C(C)=N\\OCC3=CC=C(C4CCCCC4)C(=C3)C(F)(F)F",3.834,3,0,10]
["S7189","Molibresib (I-BET-762)","c8","L3900-25","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.",{"v":423.9,"d":"423.90"},"1260907-17-2",{"v":84,"d":"84.00"},198.16,"<1","N/A","http://selleckchem.com/products/i-bet-762.html","C22H22ClN5O2","free base","GSK525762, GSK525762A","CCNC(=O)CC1N=C(C2=CC=C(Cl)C=C2)C3=CC(=CC=C3[N]4C(=NN=C14)C)OC",3.288,5,1,5]
["S7192","PF-04620110","d8","L3900-25","in 10mM DMSO","Acyltransferase,Transferase","Metabolism","PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.",396.44,"1109276-89-2",{"v":49,"d":"49.00"},{"v":123.6,"d":"123.60"},"<1","N/A","http://selleckchem.com/products/pf-04620110.html","C21H24N4O4","free base","N/A","NC1=C2C(=O)N(CCOC2=NC=N1)C3=CC=C(C=C3)C4CCC(CC4)CC(O)=O",2.797,5,1,4]
["S7194","Olverembatinib dimesylate (HQP1351)","e8","L3900-25","in 10mM DMSO","Bcr-Abl","Angiogenesis","Olverembatinib dimesylate (HQP1351, GZD824) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.",724.77,"1421783-64-3",{"v":100,"d":"100.00"},137.97,{"v":100,"d":"100.00"},137.97,"http://selleckchem.com/products/gzd824.html","C29H27F3N6O.2CH4O3S","Mesylate","GZD824 Dimesylate","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CC5=C([NH]N=C5)N=C4)C=C2)C(F)(F)F.C[S](O)(=O)=O.C[S](O)(=O)=O",4.047,3,2,7]
["S7198","BIO","f8","L3900-25","in 10mM DMSO","Apoptosis related,CDK,GSK-3,JAK","PI3K/Akt/mTOR","BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.",356.17,"667463-62-9",{"v":71,"d":"71.00"},199.34,"<1","N/A","http://selleckchem.com/products/bio.html","C16H10BrN3O2","free base","GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052","O\\N=C/1\\C(NC2=CC=CC=C12)=C3\\C(=O)NC4=C3C=CC(=C4)Br",2.692,2,2,0]
["S7205","Idasanutlin (RG-7388)","g8","L3900-25","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7211","PF-04418948","h8","L3900-25","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.",409.41,"1078166-57-0",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/pf-04418948.html","C23H20FNO5","free base","N/A","COC1=CC=C2C=C(OCC3(CN(C3)C(=O)C4=CC=C(F)C=C4)C(O)=O)C=CC2=C1",3.298,4,0,6]
["S7215","Losmapimod (GW856553X)","a9","L3900-25","in 10mM DMSO","Apoptosis related,Autophagy,p38 MAPK","MAPK","Losmapimod (GW856553X, GW856553, GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. P38 MAPKs are involved in cell differentiation, apoptosis and autophagy. Phase 3.",383.46,"585543-15-3",{"v":76,"d":"76.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/losmapimod-gw856553x.html","C22H26FN3O2","free base","GW856553, GSK-AHAB","CC1=C(F)C=C(C=C1C2=CC=C(C=N2)C(=O)NCC(C)(C)C)C(=O)NC3CC3",3.689,3,2,6]
["S7218","Alvelestat (AZD9668)","b9","L3900-25","in 10mM DMSO","Serine Protease","Proteases","Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.\n\n Phase 2.",545.53,"848141-11-7",{"v":100,"d":"100.00"},183.31,"<1","N/A","http://selleckchem.com/products/avelestat-azd9668.html","C25H22F3N5O4S","free base","Avelestat","C[N]1N=CC=C1C2=CN(C(=O)C(=C2)C(=O)NCC3=NC=C(C=C3)[S](C)(=O)=O)C4=CC=CC(=C4)C(F)(F)F",2.163,6,1,7]
["S7252","Selinexor (KPT-330)","c9","L3900-25","in 10mM DMSO","CRM1","Transmembrane Transporters","Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.",443.31,"1393477-72-9",{"v":88,"d":"88.00"},198.51,"<1","N/A","http://selleckchem.com/products/kpt-330.html","C17H11F6N7O","free base","ATG-010","FC(F)(F)C1=CC(=CC(=C1)C2=N[N](\\C=C/C(=O)NNC3=CN=CC=N3)C=N2)C(F)(F)F",2.345,5,2,7]
["S7253","AZD2858","d9","L3900-25","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.",453.52,"486424-20-8",{"v":7,"d":"7.00"},15.43,"<1","N/A","http://selleckchem.com/products/azd2858.html","C21H23N7O3S","free base","N/A","CN1CCN(CC1)[S](=O)(=O)C2=CC=C(C=C2)C3=CN=C(N)C(=N3)C(=O)NC4=CN=CC=C4",0.405,6,2,5]
["S7255","Onvansertib (NMS-P937)","e9","L3900-25","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.",532.52,"1034616-18-6",{"v":42,"d":"42.00"},78.87,"<1","N/A","http://selleckchem.com/products/nms-p937-nms1286937.html","C24H27F3N8O3","free base","PCM-075, NMS1286937","CN1CCN(CC1)C2=CC=C(OC(F)(F)F)C(=C2)NC3=NC4=C(CCC5=C4[N](CCO)N=C5C(N)=O)C=N3",4.742,5,3,8]
["S7261","Beta-Lapachone","f9","L3900-25","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.",242.27,"4707-32-8",{"v":33,"d":"33.00"},136.21,"<1","N/A","http://selleckchem.com/products/beta-lapachone.html","C15H14O3","free base","β-Lapachone, ARQ-501","CC1(C)CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O",2.509,3,0,0]
["S7262","Vidofludimus","g9","L3900-25","in 10mM DMSO","COVID-19,Dehydrogenase","Metabolism","Vidofludimus (SC12267, 4SC-101) is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.",355.36,"717824-30-1",{"v":100,"d":"100.00"},{"v":281.4,"d":"281.40"},"<1","N/A","http://selleckchem.com/products/vidofludimus.html","C20H18FNO4","free base","SC12267, 4SC-101","COC1=CC(=CC=C1)C2=CC(=C(NC(=O)C3=C(CCC3)C(O)=O)C=C2)F",3.878,3,1,5]
["S7263","AZD1981","h9","L3900-25","in 10mM DMSO","GPR","Endocrinology & Hormones","AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.",388.87,"802904-66-1",{"v":11,"d":"11.00"},28.29,"<1","N/A","http://selleckchem.com/products/azd1981.html","C19H17ClN2O3S","free base","N/A","CC(=O)NC1=C2C(=CC=C1)[N](CC(O)=O)C(=C2SC3=CC=C(Cl)C=C3)C",3.859,2,1,5]
["S7269","PD173955","a10","L3900-25","in 10mM DMSO","Bcr-Abl","Angiogenesis","PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activity with IC50 of 22 nM.",443.35,"260415-63-2",{"v":15,"d":"15.00"},33.83,"<1","N/A","http://selleckchem.com/products/pd173955.html","C21H16Cl2N4OS","free base","N/A","CSC1=CC(=CC=C1)NC2=NC3C(C=N2)C=C(C(=O)N3C)C4=C(Cl)C=CC=C4Cl",4.854,3,1,4]
["S7273","SC75741","b10","L3900-25","in 10mM DMSO","Influenza Virus,NF-κB","NF-κB","SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.",565.67,"913822-46-5",{"v":35,"d":"35.00"},61.87,"<1","N/A","http://selleckchem.com/products/sc75741.html","C29H23N7O2S2","free base","N/A","O=C(NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CC=C3)C4=CSC(=N4)C5CCN(CC5)C6=C7SC=CC7=NC=N6",{"v":5.57,"d":"5.570"},6,2,6]
["S7280","Edoxaban tosylate Monohydrate","c10","L3900-25","in 10mM DMSO","Factor Xa","Metabolism","Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.",738.27,"1229194-11-9",{"v":100,"d":"100.00"},135.45,"<1","N/A","http://selleckchem.com/products/edoxaban.html","C24H30ClN7O4S.C7H8O3S.H2O","Tosylate hydrate","DU-176b","O.CN(C)C(=O)C1CCC(NC(=O)C(=O)NC2=CC=C(Cl)C=N2)C(C1)NC(=O)C3=NC4=C(CN(C)CC4)S3.CC5=CC=C(C=C5)[S](O)(=O)=O",2.286,6,3,7]
["S7282","NMS-E973","d10","L3900-25","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.",454.43,"1253584-84-7",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/nms-e973.html","C22H22N4O7","free base","N/A","CN1CCC(CC1)NC(=O)C2=NOC(=C2)C3=C(OC4=CC=C(C=C4)[N+]([O-])=O)C=C(O)C=C3O",2.811,4,3,6]
["S7284","Rociletinib (CO-1686)","e10","L3900-25","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.",555.55,"1374640-70-6",{"v":100,"d":"100.00"},{"v":180,"d":"180.00"},"<1","N/A","http://selleckchem.com/products/co-1686.html","C27H28F3N7O3","free base","AVL-301","COC1=C(NC2=NC=C(C(=N2)NC3=CC=CC(=C3)NC(=O)C=C)C(F)(F)F)C=CC(=C1)N4CCN(CC4)C(C)=O",4.334,5,3,9]
["S7291","TAK-632","f10","L3900-25","in 10mM DMSO","Raf","MAPK","TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.",554.52,"1228591-30-7",{"v":100,"d":"100.00"},180.34,"<1","N/A","http://selleckchem.com/products/tak-632.html","C27H18F4N4O3S","free base","N/A","FC1=C(NC(=O)CC2=CC=CC(=C2)C(F)(F)F)C=C(OC3=C(C#N)C4=C(C=C3)N=C(NC(=O)C5CC5)S4)C=C1",{"v":5.74,"d":"5.740"},4,2,8]
["S7292","RG2833 (RGFP109)","g10","L3900-25","in 10mM DMSO","HDAC","Epigenetics","RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3 in cell-free assays, respectively.",339.43,"1215493-56-3",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://selleckchem.com/products/rg2833-rgfp109.html","C20H25N3O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N",2.895,2,3,8]
["S7295","Apabetalone (RVX-208)","h10","L3900-25","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.",{"v":370.4,"d":"370.40"},"1044870-39-4",{"v":74,"d":"74.00"},199.78,"<1","N/A","http://selleckchem.com/products/rvx-208.html","C20H22N2O5","free base","RVX-000222","COC1=CC(=C2C(=O)NC(=NC2=C1)C3=CC(=C(OCCO)C(=C3)C)C)OC",2.877,5,2,6]
["S7297","Osimertinib (AZD9291)","a11","L3900-25","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.",499.61,"1421373-65-0",{"v":99,"d":"99.00"},198.15,"<1","N/A","http://selleckchem.com/products/azd9291.html","C28H33N7O2","free base","Mereletinib","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",4.671,4,2,10]
["S7303","Rilpivirine","b11","L3900-25","in 10mM DMSO","Reverse Transcriptase","Microbiology","Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.",366.42,"500287-72-9",{"v":73,"d":"73.00"},199.22,"<1","N/A","http://selleckchem.com/products/rilpivirine.html","C22H18N6","free base","R278474, TMC278, DB08864","CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N",5.409,2,2,5]
["S7304","CPI-203","c11","L3900-25","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","CPI-203 is a potent BET bromodomain inhibitor with IC50 of 37 nM for BRD4.",{"v":399.9,"d":"399.90"},"1446144-04-2",{"v":79,"d":"79.00"},197.55,"<1","N/A","http://selleckchem.com/products/cpi-203.html","C19H18ClN5OS","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(N)=O)N=C2C4=CC=C(Cl)C=C4)C",3.168,4,1,3]
["S7309","BAY 87-2243","d11","L3900-25","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7323","Itanapraced (CHF 5074)","e11","L3900-25","in 10mM DMSO","Secretase,Secretase","Proteases","Itanapraced (CHF 5074, CSP-1103) is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L.",325.16,"749269-83-8",{"v":65,"d":"65.00"},{"v":199.9,"d":"199.90"},"<1","N/A","http://www.selleckchem.com/products/chf-5074.html","C16H11Cl2FO2","Free Base","CSP-1103","OC(=O)C1(CC1)C2=CC(=C(C=C2)C3=CC=C(Cl)C(=C3)Cl)F",5.055,1,0,3]
["S7326","Tasisulam","f11","L3900-25","in 10mM DMSO","Caspase","Apoptosis","Tasisulam (LY573636) is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.",415.11,"519055-62-0",{"v":83,"d":"83.00"},199.95,"<1","N/A","http://selleckchem.com/products/tasisulam.html","C11H6BrCl2NO3S2","free base","LY573636","ClC1=CC(=C(C=C1)C(=O)N[S](=O)(=O)C2=CC=C(Br)S2)Cl",3.872,3,1,3]
["S7329","IOWH032","g11","L3900-25","in 10mM DMSO","CFTR","Transmembrane Transporters","IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.",545.18,"1191252-49-9",{"v":100,"d":"100.00"},183.43,"<1","N/A","http://selleckchem.com/products/iowh032.html","C22H15Br2N3O4","free base","N/A","OC1=C(Br)C=C(C=C1Br)C2=NOC(=N2)C(=O)NCC3=CC=C(OC4=CC=CC=C4)C=C3",5.233,5,2,6]
["S7336","CW069","h11","L3900-25","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.",500.33,"1594094-64-0",{"v":100,"d":"100.00"},199.87,"<1","N/A","http://selleckchem.com/products/cw069.html","C23H21IN2O3","free base","N/A","OC(=O)C1=CC(=CC=C1NC(=O)C(CC2=CC=CC=C2)NCC3=CC=CC=C3)I",1.547,2,2,8]
["S7339","AZD3965","a2","L3900-26","in 10mM DMSO","MCT","Transmembrane Transporters","AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.",515.51,"1448671-31-5",{"v":100,"d":"100.00"},193.98,"<1","N/A","http://selleckchem.com/products/azd3965.html","C21H24F3N5O5S","free base","N/A","CC(C)N1C(=O)N(C)C(=O)C2=C1SC(=C2C(=O)N3CC(C)(O)CO3)CC4=C(C)[NH]N=C4C(F)(F)F",2.066,5,1,5]
["S7355","ARQ 621","b2","L3900-26","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.",552.43,"1095253-39-6",{"v":100,"d":"100.00"},181.02,"<1","N/A","http://selleckchem.com/products/arq-621.html","C28H24Cl2FN5O2","free base","N/A","NCCCN(C(CC#C)C1=NC2=C(C=CC(=C2)Cl)C(=O)N1NC3=CC=CC=C3)C(=O)C4=CC=CC(=C4F)Cl",{"v":5.98,"d":"5.980"},3,2,9]
["S7357","PF-562271 HCl","c2","L3900-26","in 10mM DMSO","CDK,FAK,Pyk2","Angiogenesis","PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.",543.95,"939791-41-0",{"v":100,"d":"100.00"},183.84,"<1","N/A","http://selleckchem.com/products/pf-562271-hcl.html","C21H21ClF3N7O3S","Hydrochloride","N/A","Cl.CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O",2.873,6,3,8]
["S7358","Poziotinib (HM781-36B)","d2","L3900-26","in 10mM DMSO","Apoptosis related,EGFR,HER2","Protein Tyrosine Kinase","Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.",491.34,"1092364-38-9",{"v":98,"d":"98.00"},199.45,"<1","N/A","http://selleckchem.com/products/poziotinib-hm781-36b.html","C23H21Cl2FN4O3","free base","NOV120101","COC1=CC2=C(C=C1OC3CCN(CC3)C(=O)C=C)C(=NC=N2)NC4=CC=C(Cl)C(=C4F)Cl",5.046,5,1,6]
["S7360","Birabresib (OTX015)","e2","L3900-26","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",491.99,"202590-98-5",{"v":98,"d":"98.00"},199.19,"<1","N/A","http://selleckchem.com/products/otx015.html","C25H22ClN5O2S","free base","MK 8628","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(O)C=C4)N=C2C5=CC=C(Cl)C=C5)C",4.709,4,2,4]
["S7369","4EGI-1","f2","L3900-26","in 10mM DMSO","Apoptosis related,eIF,mTOR","Cell Cycle","4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.",451.28,"315706-13-9",{"v":90,"d":"90.00"},199.43,"<1","N/A","http://selleckchem.com/products/4egi-1.html","C18H12Cl2N4O4S","free base","N/A","OC(=O)C(/CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(=CS2)C3=CC=C(Cl)C(=C3)Cl",5.397,3,1,7]
["S7379","E-64","g2","L3900-26","in 10mM DMSO","Apoptosis related,Cathepsin B,Cysteine Protease,Parasite","Proteases","E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.",357.41,"66701-25-5",{"v":71,"d":"71.00"},198.65,{"v":11,"d":"11.00"},30.78,"http://selleckchem.com/products/e-64.html","C15H27N5O5","free base","N/A","CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCNC(N)=N",-0.864,4,4,12]
["S7381","Pepstatin A","h2","L3900-26","in 10mM DMSO","Autophagy,Cysteine Protease,HIV Protease","Proteases","Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.",685.89,"26305-03-3",{"v":57,"d":"57.00"},{"v":83.1,"d":"83.10"},"<1","N/A","http://selleckchem.com/products/pepstatin-a.html","C34H63N5O9","free base","Pepstatin","CC(C)CC(NC(=O)C(C)NC(=O)CC(O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)C(O)CC(O)=O",2.301,6,7,22]
["S7393","Aloxistatin (E64d)","a3","L3900-26","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.",342.43,"88321-09-9",{"v":68,"d":"68.00"},198.58,"<1","N/A","http://selleckchem.com/products/Aloxistatin.html","C17H30N2O5","free base","E-64d","CCOC(=O)C1OC1C(=O)NC(CC(C)C)C(=O)NCCC(C)C",1.611,5,2,11]
["S7396","Calpeptin","b3","L3900-26","in 10mM DMSO","Apoptosis related,Cysteine Protease","Proteases","Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.",362.46,"117591-20-5",{"v":72,"d":"72.00"},198.64,"<1","N/A","http://selleckchem.com/products/calpeptin.html","C20H30N2O4","free base","N/A","CCCCC(NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",{"v":3.8,"d":"3.800"},4,2,12]
["S7397","Sorafenib (BAY 43-9006)","c3","L3900-26","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1","N/A","http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7411","Ascomycin (FK520)","d3","L3900-26","in 10mM DMSO","Anti-infection","Microbiology","Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.",792.01,"104987-12-4",{"v":100,"d":"100.00"},126.26,"<1","N/A","http://selleckchem.com/products/ascomycin-fk520.html","C43H69NO12","free base","FR 900520, Immunomycin","CCC1/C=C(C)/CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)\\C(C)=C\\C4CCC(O)C(C4)OC",4.766,9,2,6]
["S7435","AR-A014418","e3","L3900-26","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.",308.31,"487021-52-3",{"v":61,"d":"61.00"},197.85,"<1","N/A","http://selleckchem.com/products/A014418.html","C12H12N4O4S","free base","GSK-3β Inhibitor VIII","COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1",1.529,3,2,5]
["S7440","Ribociclib (LEE011)","f3","L3900-26","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.",434.54,"1211441-98-3",{"v":7,"d":"7.00"},16.11,"<1","N/A","http://selleckchem.com/products/lee011.html","C23H30N8O","free base","N/A","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",{"v":2.9,"d":"2.900"},4,2,5]
["S7445","APX-3330","g3","L3900-26","in 10mM DMSO","DNA/RNA Synthesis,NF-κB","DNA Damage/DNA Repair","APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.",378.46,"136164-66-4",{"v":75,"d":"75.00"},198.17,"<1","N/A","http://selleckchem.com/products/e3330.html","C21H30O6","free base","E3330","CCCCCCCCCC(=C/C1=C(C)C(=O)C(=C(OC)C1=O)OC)\\C(O)=O",4.663,5,0,12]
["S7458","VER-49009","h3","L3900-26","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-49009 (CCT0129397) is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.",387.82,"940289-57-6",{"v":77,"d":"77.00"},198.55,"<1","N/A","http://selleckchem.com/products/ver-49009.html","C19H18ClN3O4","free base","CCT0129397","CCNC(=O)C1=C(C2=CC=C(OC)C=C2)C(=N[NH]1)C3=CC(=C(O)C=C3O)Cl",3.751,3,4,5]
["S7465","FTI 277 HCl","a4","L3900-26","in 10mM DMSO","Anti-infection,Apoptosis related,FTase,Transferase","Metabolism","FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.",484.07,"180977-34-8",{"v":96,"d":"96.00"},198.32,{"v":17,"d":"17.00"},35.12,"http://selleckchem.com/products/fti-277-hcl.html","C22H30ClN3O3S2","hydrochloride salt","N/A","Cl.COC(=O)C(CCSC)NC(=O)C1=C(C=C(NCC(N)CS)C=C1)C2=CC=CC=C2",2.897,3,3,12]
["S7466","GGTI 298 TFA salt","b4","L3900-26","in 10mM DMSO","Transferase","Metabolism","GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.",593.66,"1217457-86-7",{"v":100,"d":"100.00"},168.45,"<1","N/A","http://selleckchem.com/products/ggti-298.html","C27H33N3O3S.C2HF3O2","trifluoroacetat","N/A","COC(=O)C(CC(C)C)NC(=O)C1=CC=C(NCC(N)CS)C=C1C2=C3C=CC=CC3=CC=C2.OC(=O)C(F)(F)F",2.733,4,3,12]
["S7470","Triapine","c4","L3900-26","in 10mM DMSO","DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.",195.24,"200933-27-3",{"v":20,"d":"20.00"},102.44,"<1","N/A","http://selleckchem.com/products/triapine.html","C7H9N5S","free base","3-AP","NC(=S)N/N=C/C1=NC=CC=C1N",0.331,2,3,3]
["S7482","EHT 1864 2HCl","d4","L3900-26","in 10mM DMSO","Rho","Cell Cycle","EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.",581.47,"754240-09-0",{"v":100,"d":"100.00"},171.98,{"v":100,"d":"100.00"},171.98,"http://selleckchem.com/products/eht-1864.html","C25H29Cl2F3N2O4S","dihydrochloride","N/A","Cl.Cl.FC(F)(F)C1=CC2=C(C=C1)C(=CC=N2)SCCCCCOC3=COC(=CC3=O)CN4CCOCC4",4.663,5,0,11]
["S7488","MPI-0479605","e4","L3900-26","in 10mM DMSO","MPS1","Cell Cycle","MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.",407.51,"1246529-32-7",{"v":62,"d":"62.00"},152.14,"<1","N/A","http://selleckchem.com/products/mpi-0479605.html","C22H29N7O","free base","N/A","CC1=CC(=CC=C1NC2=NC3=C(N=C[NH]3)C(=N2)NC4CCCCC4)N5CCOCC5",4.379,4,3,5]
["S7492","Uprosertib (GSK2141795)","f4","L3900-26","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Uprosertib (GSK2141795, GSK795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.",429.25,"1047634-65-0",{"v":85,"d":"85.00"},198.02,"<1","N/A","http://selleckchem.com/products/gsk2141795.html","C18H16Cl2F2N4O2","free base","GSK795","C[N]1N=CC(=C1C2=C(Cl)OC(=C2)C(=O)NC(CN)CC3=CC(=C(F)C=C3)F)Cl",3.531,3,2,6]
["S7505","(S)-crizotinib","g4","L3900-26","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.",450.34,"1374356-45-2",{"v":42,"d":"42.00"},93.26,"<1","N/A","http://selleckchem.com/products/s-crizotinib.html","C21H22Cl2FN5O","free base","N/A","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S7513","Trelagliptin","h4","L3900-26","in 10mM DMSO","DPP","Proteases","Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).",357.38,"865759-25-7",{"v":71,"d":"71.00"},198.67,"<1","N/A","http://selleckchem.com/products/trelagliptin.html","C18H20FN5O2","free base","SYR-472","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC(=CC=C3C#N)F)C1=O",1.476,2,1,3]
["S7515","VGX-1027","a5","L3900-26","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","VGX-1027 (GIT 27) is an orally active immunomodulator. Phase 1.",205.21,"6501-72-0",{"v":41,"d":"41.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/vgx-1027.html","C11H11NO3","free base","GIT 27","OC(=O)CC1CC(=NO1)C2=CC=CC=C2",1.368,3,0,3]
["S7517","AZD7545","b5","L3900-26","in 10mM DMSO","PDHK","Metabolism","AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.",478.87,"252017-04-2",{"v":95,"d":"95.00"},198.38,"<1","N/A","http://selleckchem.com/products/azd7545.html","C19H18ClF3N2O5S","free base","N/A","CN(C)C(=O)C1=CC=C(C=C1)[S](=O)(=O)C2=CC(=C(NC(=O)C(C)(O)C(F)(F)F)C=C2)Cl",2.913,4,1,6]
["S7520","Darapladib (SB-480848)","c5","L3900-26","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.",666.77,"356057-34-6",{"v":100,"d":"100.00"},149.98,"<1","N/A","http://selleckchem.com/products/darapladib-sb-480848.html","C36H38F4N4O2S","free base","N/A","CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCC5=CC=C(F)C=C5",7.707,3,0,14]
["S7521","Afuresertib (GSK2110183)","d5","L3900-26","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.",427.32,"1047644-62-1",{"v":85,"d":"85.00"},198.91,"<1","N/A","http://selleckchem.com/products/afuresertib-gsk2110183.html","C18H17Cl2FN4OS","free base","N/A","C[N]1N=CC(=C1C2=C(Cl)SC(=C2)C(=O)NC(CN)CC3=CC=CC(=C3)F)Cl",3.884,2,2,6]
["S7523","Entospletinib (GS-9973)","e5","L3900-26","in 10mM DMSO","Syk","Angiogenesis","Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.",411.46,"1229208-44-9",{"v":26,"d":"26.00"},63.19,"<1","N/A","http://selleckchem.com/products/gs-9973.html","C23H21N7O","free base","N/A","C1CN(CCO1)C2=CC=C(NC3=NC(=C[N]4C=CN=C34)C5=CC=C6C=N[NH]C6=C5)C=C2",2.949,4,2,4]
["S7530","Vactosertib (TEW-7197)","f5","L3900-26","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Vactosertib  (TEW-7197, EW-7197) is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1.",399.42,"1352608-82-2",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/ew-7197.html","C22H18FN7","free base","EW-7197","CC1=NC(=CC=C1)C2=C(N=C(CNC3=CC=CC=C3F)[NH]2)C4=C[N]5N=CN=C5C=C4",3.621,4,2,5]
["S7536","Lorlatinib (PF-6463922)","g5","L3900-26","in 10mM DMSO","ALK,Apoptosis related,ROS1","Protein Tyrosine Kinase","Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 induces apoptosis. Phase 1.",406.41,"1454846-35-5",{"v":81,"d":"81.00"},199.31,"<1","N/A","http://selleckchem.com/products/pf-06463922.html","C21H19FN6O2","free base","N/A","CC1OC2=C(N)N=CC(=C2)C3=C(C#N)[N](C)N=C3CN(C)C(=O)C4=C1C=C(F)C=C4",2.343,4,1,0]
["S7540","SB273005","h5","L3900-26","in 10mM DMSO","Integrin","Cytoskeletal Signaling","SB273005 is a potent integrin inhibitor with Ki  of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.",451.44,"205678-31-5",{"v":90,"d":"90.00"},199.36,"<1","N/A","http://selleckchem.com/products/sb273005.html","C22H24F3N3O4","free base","N/A","CNC1=CC=CC(=N1)CCOC2=CC=C3CC(CC(O)=O)C(=O)N(CC3=C2)CC(F)(F)F",3.364,4,1,9]
["S7541","Decernotinib (VX-509)","a6","L3900-26","in 10mM DMSO","JAK","JAK/STAT","Decernotinib (VX-509) is a potent and selective JAK3 inhibitor with Ki of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3.",392.38,"944842-54-0",{"v":78,"d":"78.00"},198.79,"<1","N/A","http://selleckchem.com/products/decernotinib-vx-509.html","C18H19F3N6O","free base","N/A","CCC(C)(NC1=NC(=NC=C1)C2=C[NH]C3=NC=CC=C23)C(=O)NCC(F)(F)F",2.747,4,3,7]
["S7546","Pritelivir (BAY 57-1293)","b6","L3900-26","in 10mM DMSO","DNA/RNA Synthesis,HSV","DNA Damage/DNA Repair","Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.",402.49,"348086-71-5",{"v":80,"d":"80.00"},198.76,"<1","N/A","http://selleckchem.com/products/bay-57-1293.html","C18H18N4O3S2","free base","AIC316","CN(C(=O)CC1=CC=C(C=C1)C2=NC=CC=C2)C3=NC(=C(S3)[S](N)(=O)=O)C",1.761,5,1,5]
["S7549","THZ1 2HCl","c6","L3900-26","in 10mM DMSO","CDK","Cell Cycle","THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.",638.97,"2095433-94-4",{"v":100,"d":"100.00"},{"v":156.5,"d":"156.50"},"<1","N/A","http://selleckchem.com/products/thz1.html","C31H30Cl3N7O2","dihydrochloride","N/A","Cl.Cl.CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC=C5",6.383,4,4,9]
["S7550","Erythromycin Cyclocarbonate","d6","L3900-26","in 10mM DMSO","Bacterial","Microbiology","Erythromycin Cyclocarbonate(Davercin), derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome.",759.92,"55224-05-0",{"v":100,"d":"100.00"},131.59,"<1","N/A","http://selleckchem.com/products/erythromycin-cyclocarbonate.html","C38H65NO14","free base","Davercin","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=O)C(C)C4OC(=O)OC14C",3.172,11,2,7]
["S7552","CFI-400945","e6","L3900-26","in 10mM DMSO","PLK","Cell Cycle","CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM.",534.65,"1338806-73-7",{"v":100,"d":"100.00"},187.04,"<1","N/A","http://selleckchem.com/products/cfi-400945.html","C33H34N4O3","free base","N/A","COC1=CC2=C(NC(=O)C23CC3C4=CC=C5C(=C4)[NH]N=C5\\C=C\\C6=CC=C(CN7CC(C)OC(C)C7)C=C6)C=C1",5.169,4,2,6]
["S7553","GDC-0623","f6","L3900-26","in 10mM DMSO","MEK","MAPK","GDC-0623 (G-868) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.",456.21,"1168091-68-6",{"v":91,"d":"91.00"},199.47,"<1","N/A","http://selleckchem.com/products/gdc-0623.html","C16H14FIN4O3","free base","G-868","OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)[N]3C=NC=C3C=C1",2.284,3,3,6]
["S7555","Domatinostat (4SC-202)","g6","L3900-26","in 10mM DMSO","HDAC","Epigenetics","Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.",447.51,"910462-43-0",{"v":89,"d":"89.00"},198.88,"<1","N/A","http://selleckchem.com/products/4sc-202.html","C23H21N5O3S","free base","N/A","C[N]1C=C(C=N1)C2=CC=C(C=C2)[S](=O)(=O)[N]3C=CC(=C3)\\C=C\\C(=O)NC4=CC=CC=C4N",2.955,4,2,6]
["S7557","CL-387785 (EKI-785)","h6","L3900-26","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","CL-387785 (EKI-785, WAY-EKI 785) is an irreversible, and selective EGFR inhibitor with IC50 of 370 pM.",381.23,"194423-06-8",{"v":63,"d":"63.00"},165.25,"<1","N/A","http://selleckchem.com/products/cl-387785-eki-785.html","C18H13BrN4O","free base","WAY-EKI 785","CC#CC(=O)NC1=CC2=C(NC3=CC=CC(=C3)Br)N=CN=C2C=C1",4.568,3,2,4]
["S7559","Darolutamide (ODM-201)","a7","L3900-26","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. Phase 3.",398.85,"1297538-32-9",{"v":80,"d":"80.00"},200.58,"<1","N/A","http://selleckchem.com/products/odm-201.html","C19H19ClN6O2","free base","BAY-1841788","CC(O)C1=CC(=N[NH]1)C(=O)NC(C)C[N]2C=CC(=N2)C3=CC(=C(C=C3)C#N)Cl",3.034,3,3,6]
["S7563","AT13148","b7","L3900-26","in 10mM DMSO","Akt,PKA,ROCK,S6 Kinase","PI3K/Akt/mTOR","AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.",313.78,"1056901-62-2",{"v":62,"d":"62.00"},197.59,"<1","N/A","http://selleckchem.com/products/at13148.html","C17H16ClN3O","free base","N/A","NCC(O)(C1=CC=C(Cl)C=C1)C2=CC=C(C=C2)C3=C[NH]N=C3",2.491,1,2,4]
["S7564","SAR125844","c7","L3900-26","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).",550.63,"1116743-46-4",{"v":11,"d":"11.00"},19.98,"<1","N/A","http://www.selleck.cn/products/sar125844.html","C25H23FN8O2S2","free base","N/A","FC1=CC=C(C=C1)C2=N[N]3C(=NN=C3C=C2)SC4=CC=C5N=C(NC(=O)NCCN6CCOCC6)SC5=C4",4.518,6,2,7]
["S7579","Ledipasvir (GS5885)","d7","L3900-26","in 10mM DMSO","COVID-19,HCV Protease","Microbiology","Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.",{"v":889,"d":"889.00"},"1256388-51-8",{"v":100,"d":"100.00"},112.49,"<1","N/A","http://selleckchem.com/products/ledipasvir-gs5885.html","C49H54F2N8O6","free base","N/A","COC(=O)NC(C(C)C)C(=O)N1C2CCC(C2)C1C3=NC4=CC=C(C=C4[NH]3)C5=CC=C6C7=CC=C(C=C7C(F)(F)C6=C5)C8=CN=C([NH]8)C9CCC%10(CC%10)N9C(=O)C(NC(=O)OC)C(C)C",7.304,8,4,12]
["S7582","Anacardic Acid","e7","L3900-26","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,\n\nprostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.",348.52,"16611-84-0",{"v":69,"d":"69.00"},197.98,"<1","N/A","http://selleckchem.com/products/anacardic-acid.html","C22H36O3","free base","6-pentadecylsalicylic Acid","CCCCCCCCCCCCCCCC1=CC=CC(=C1C(O)=O)O",{"v":8.09,"d":"8.090"},1,1,15]
["S7585","SB-334867","f7","L3900-26","in 10mM DMSO","OX Receptor","GPCR & G Protein","SB-334867 is a selective orexin-1 (OX1) receptor antagonist.",319.32,"792173-99-0",{"v":63,"d":"63.00"},197.29,"<1","N/A","http://selleckchem.com/products/sb-334867.html","C17H13N5O2","free base","N/A","CC1=NC2=C(O1)C=C(NC(=O)NC3=CC=NC4=CC=CN=C34)C=C2",1.773,5,2,2]
["S7589","N6022","g7","L3900-26","in 10mM DMSO","Others","Metabolism","N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.",414.46,"1208315-24-5",{"v":82,"d":"82.00"},197.85,"<1","N/A","http://selleckchem.com/products/n6022.html","C24H22N4O3","free base","N/A","CC1=C(C=CC(=C1)C(N)=O)[N]2C(=CC=C2C3=CC=C(C=C3)[N]4C=CN=C4)CCC(O)=O",3.664,3,1,7]
["S7594","Abscisic Acid (Dormin)","h7","L3900-26","in 10mM DMSO","Others","Endocrinology & Hormones","Abscisic Acid (Dormin, Abscisin II) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.",264.32,"21293-29-8",{"v":52,"d":"52.00"},196.73,"<1","N/A","http://selleckchem.com/products/abscisic-acid-dormin.html","C15H20O4","free base","Abscisin II","CC(/C=C/C1(O)C(=CC(=O)CC1(C)C)C)=C/C(O)=O",2.161,2,0,3]
["S7605","Filgotinib (GLPG0634)","a8","L3900-26","in 10mM DMSO","JAK","JAK/STAT","Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.",{"v":425.5,"d":"425.50"},"1206161-97-8",{"v":85,"d":"85.00"},199.76,"<1","N/A","http://selleckchem.com/products/filgotinib.html","C21H23N5O3S","free base","N/A","O=C(NC1=N[N]2C(=N1)C=CC=C2C3=CC=C(CN4CC[S](=O)(=O)CC4)C=C3)C5CC5",2.461,5,1,5]
["S7612","PX-478 2HCl","b8","L3900-26","in 10mM DMSO","Apoptosis related,HIF","Angiogenesis","PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.",394.12,"685898-44-6",{"v":78,"d":"78.00"},197.91,{"v":78,"d":"78.00"},197.91,"http://selleckchem.com/products/px-478-2hcl.html","C13H20Cl4N2O3","dihydrochloride","N/A","Cl.Cl.NC(CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O",-0.251,1,1,8]
["S7616","CPI-169","c8","L3900-26","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.",528.66,"1450655-76-1",{"v":100,"d":"100.00"},189.16,"<1","N/A","http://selleckchem.com/products/cpi-169.html","C27H36N4O5S","free base","N/A","CC[S](=O)(=O)N1CCC(CC1)C(C)[N]2C(=C(C(=O)NCC3=C(OC)C=C(C)NC3=O)C4=CC=CC=C24)C",{"v":1.74,"d":"1.740"},5,2,8]
["S7617","Tasquinimod","d8","L3900-26","in 10mM DMSO","HDAC","Angiogenesis","Tasquinimod (ABR-215050) is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.",406.36,"254964-60-8",{"v":81,"d":"81.00"},199.33,"<1","N/A","http://selleckchem.com/products/tasquinimod.html","C20H17F3N2O4","free base","ABR-215050","COC1=C2C(=C(C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C2=CC=C1)O",2.797,3,1,4]
["S7618","MI-2 (Menin-MLL Inhibitor)","e8","L3900-26","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.",375.55,"1271738-62-5",{"v":75,"d":"75.00"},199.71,"<1","N/A","http://selleckchem.com/products/mi-2-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.161,3,0,4]
["S7624","SD-208","f8","L3900-26","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.",352.75,"627536-09-8",{"v":9,"d":"9.00"},25.51,"<1","N/A","http://selleckchem.com/products/sd-208.html","C17H10ClFN6","free base","N/A","FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4",3.139,5,1,3]
["S7625","Niraparib (MK-4827) tosylate","g8","L3900-26","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.",492.59,"1038915-73-9",{"v":98,"d":"98.00"},198.95,"<1","N/A","http://selleckchem.com/products/mk-4827-niraparib-tosylate.html","C19H20N4O.C7H8O3S","4-?methylbenzen","Niraparib tosylate, MK 4827 tosylate, ZEJULA","CC1=CC=C(C=C1)[S](O)(=O)=O.NC(=O)C2=CC=CC3=C[N](N=C23)C4=CC=C(C=C4)C5CCCNC5",4.267,2,2,4]
["S7633","Lomitapide Mesylate","h8","L3900-26","in 10mM DMSO","MTP","Transmembrane Transporters","Lomitapide Mesylate(AEGR-733 Mesylate,BMS-2138 Mesylate) is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.",789.83,"202914-84-9",{"v":100,"d":"100.00"},126.61,"<1","N/A","http://selleckchem.com/products/lomitapide-mesylate.html","C40H41F6N3O5S","Mesylate","AEGR-733 Mesylate,BMS-2138 Mesylate","C[S](O)(=O)=O.FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)C5=C(C=CC=C5)C6=C1C=CC=C6",7.377,2,2,12]
["S7634","Cerdulatinib (PRT062070) hydrochloride","a9","L3900-26","in 10mM DMSO","JAK,Syk","JAK/STAT","Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.",{"v":482,"d":"482.00"},"1369761-01-2",{"v":43,"d":"43.00"},89.21,"<1","N/A","http://selleckchem.com/products/cerdulatinib-prt062070-prt2070.html","C20H28ClN7O3S","hydrochloride","PRT2070 hydrochloride","Cl.CC[S](=O)(=O)N1CCN(CC1)C2=CC=C(NC3=NC(=C(C=N3)C(N)=O)NC4CC4)C=C2",1.862,5,3,8]
["S7635","Lomitapide","b9","L3900-26","in 10mM DMSO","MTP","Transmembrane Transporters","Lomitapide (AEGR-733, BMS-201038) is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.",692.71,"182431-12-5",{"v":100,"d":"100.00"},144.36,"<1","N/A","http://selleckchem.com/products/lomitapide.html","C39H37F6N3O2","free base","AEGR-733, BMS-201038","FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)C5=C(C=CC=C5)C6=C1C=CC=C6",{"v":7.79,"d":"7.790"},2,2,12]
["S7636","SU9516","c9","L3900-26","in 10mM DMSO","CDK","Cell Cycle","SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.",241.25,"377090-84-1",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/su9516.html","C13H11N3O2","free base","N/A","COC1=CC=C2NC(=O)C(=C\\C3=CN=C[NH]3)/C2=C1",0.893,3,2,2]
["S7637","DTP3","d9","L3900-26","in 10mM DMSO","DNA/RNA Synthesis,JNK,NF-κB","MAPK","DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.",{"v":525.6,"d":"525.60"},"1809784-29-9",{"v":100,"d":"100.00"},190.26,{"v":100,"d":"100.00"},190.26,"http://selleckchem.com/products/dtp3.html","C26H35N7O5","free base","N/A","CC(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC2=CC=CC=C2)C(N)=O",{"v":0,"d":"0.000"},4,7,15]
["S7639","3PO","e9","L3900-26","in 10mM DMSO","PFKFB","Cell Cycle","3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.",210.23,"18550-98-6",{"v":42,"d":"42.00"},199.78,"<1","N/A","http://selleckchem.com/products/3po.html","C13H10N2O","free base","3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one","O=C(/C=C/C1=CC=CN=C1)C2=CC=NC=C2",{"v":1.4,"d":"1.400"},3,0,3]
["S7645","Pilaralisib (XL147)","f9","L3900-26","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.",541.02,"934526-89-3",{"v":100,"d":"100.00"},184.84,"<1","N/A","http://selleckchem.com/products/pilaralisib-xl147.html","C25H25ClN6O4S","free base","N/A","COC1=CC(=C(Cl)C=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=CC(=C4)NC(=O)C(C)(C)N",4.012,6,4,8]
["S7646","Voxtalisib (XL765)","g9","L3900-26","in 10mM DMSO","mTOR,PI3K","Angiogenesis","Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",270.29,"934493-76-2",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/voxtalisib-xl765-sar245409.html","C13H14N6O","free base","SAR245409","CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C3=CC=N[NH]3",0.838,4,2,2]
["S7648","OTS964","h9","L3900-26","in 10mM DMSO","Apoptosis related,Autophagy,CDK,TOPK","MAPK","OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.",428.97,"1338545-07-5",{"v":85,"d":"85.00"},198.15,"<1","N/A","http://selleckchem.com/products/ots964.html","C23H24N2O2S.HCl","dihydrochloride","N/A","Cl.Cl.CC(CN(C)C)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",5.497,1,2,4]
["S7649","MI-773 (SAR405838)","a10","L3900-26","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7650","Peficitinib (ASP015K)","b10","L3900-26","in 10mM DMSO","JAK","JAK/STAT","Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.",326.39,"944118-01-8",{"v":65,"d":"65.00"},199.15,"<1","N/A","http://selleckchem.com/products/peficitinb-asp015k-jnj-54781532.html","C18H22N4O2","free base","JNJ-54781532","NC(=O)C1=C(N[CH]2C3C[CH]4CC2C[C](O)(C4)C3)C5=C([NH]C=C5)N=C1",1.023,2,3,3]
["S7651","SB225002","c10","L3900-26","in 10mM DMSO","CXCR","GPCR & G Protein","SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.",352.14,"182498-32-4",{"v":70,"d":"70.00"},198.78,"<1","N/A","http://selleckchem.com/products/sb225002.html","C13H10BrN3O4","free base","N/A","OC1=CC(=CC=C1NC(=O)NC2=C(Br)C=CC=C2)[N+]([O-])=O",2.923,1,3,3]
["S7652","OTS514 hydrochloride","d10","L3900-26","in 10mM DMSO","Apoptosis related,TOPK","MAPK","OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.",400.92,"2319647-76-0",{"v":80,"d":"80.00"},199.54,{"v":80,"d":"80.00"},199.54,"http://selleckchem.com/products/ots514.html","C21H20N2O2S.HCl","hydrochloride","N/A","Cl.CC(CN)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",4.147,1,3,3]
["S7653","PND-1186 (VS-4718)","e10","L3900-26","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","PND-1186 (VS-4718, SR-2156) is a reversible and selective FAK inhibitor with IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis. Phase 1.",{"v":501.5,"d":"501.50"},"1061353-68-1",{"v":24,"d":"24.00"},47.86,"<1","N/A","http://selleckchem.com/products/pnd-1186-vs-4718.html","C25H26F3N5O3","free base","SR-2156","CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3OC)N4CCOCC4",4.302,4,3,8]
["S7655","Telaglenastat (CB-839)","f10","L3900-26","in 10mM DMSO","Autophagy,Glutaminase","Proteases","Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.",571.57,"1439399-58-2",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/cb-839.html","C26H24F3N7O3S","free base","N/A","FC(F)(F)OC1=CC(=CC=C1)CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2",5.597,8,2,13]
["S7656","CPI-360","g10","L3900-26","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.",437.53,"1802175-06-9",{"v":20,"d":"20.00"},45.71,"<1","N/A","http://selleckchem.com/products/cpi-360.html","C25H31N3O4","free base","N/A","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCOCC3)C4=C2C=CC=C4)C(=O)NC(=C1)C",2.071,4,2,6]
["S7660","Obeticholic Acid","h10","L3900-26","in 10mM DMSO","Autophagy,FXR","Metabolism","Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.",420.63,"459789-99-2",{"v":84,"d":"84.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/obeticholic-acid.html","C26H44O4","free base","INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid","CCC1C(O)C2C3CCC(C(C)CCC(O)=O)C3(C)CCC2C4(C)CCC(O)CC14",{"v":4.79,"d":"4.790"},1,2,5]
["S7663","Ruboxistaurin (LY333531) HCl","a11","L3900-26","in 10mM DMSO","PKC","TGF-beta/Smad","Ruboxistaurin (LY333531) HCl is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.",505.01,"169939-93-9",{"v":50,"d":"50.00"},99.01,"<1","N/A","http://selleckchem.com/products/ly333531.html","C28H28N4O3.HCl","hydrochloride","Ruboxistaurin hydrochloride,  LY333531 hydrochloride","Cl.CN(C)CC1CC[N]2C=C(C3=C2C=CC=C3)C4=C(C(=O)NC4=O)C5=C[N](CCO1)C6=C5C=CC=C6",3.861,3,1,2]
["S7665","Zoligratinib (Debio-1347)","b11","L3900-26","in 10mM DMSO","FGFR","Angiogenesis","Zoligratinib (Debio-1347, CH5183284, FF284) is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.",356.38,"1265229-25-1",{"v":71,"d":"71.00"},199.23,"<1","N/A","http://selleckchem.com/products/ch5183284-debio-1347.html","C20H16N6O","free base","CH5183284, FF284","CC1=NC2=C([NH]1)C=C(C=C2)[N]3N=CC(=C3N)C(=O)C4=CC5=C([NH]4)C=CC=C5",3.199,3,3,3]
["S7667","SU5402","c11","L3900-26","in 10mM DMSO","FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.",296.32,"215543-92-3",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/su5402.html","C17H16N2O3","free base","N/A","CC1=C[NH]C(=C1CCC(O)=O)C=C2C(=O)NC3=C2C=CC=C3",2.723,2,2,4]
["S7668","Picropodophyllin (PPP)","d11","L3900-26","in 10mM DMSO","Apoptosis related,IGF-1R","Protein Tyrosine Kinase","Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.",414.41,"477-47-4",{"v":82,"d":"82.00"},197.87,"<1","N/A","http://selleckchem.com/products/picropodophyllin-ppp.html","C22H22O8","free base","AXL1717","COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24",2.111,7,1,4]
["S7672","Omaveloxolone (RTA-408)","e11","L3900-26","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.",554.71,"1474034-05-3",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/omaveloxolone-rta-408.html","C33H44F2N2O3","free base","N/A","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C3(C)CCC5C(C)(C)C(=O)C(=CC45C)C#N)NC(=O)C(C)(F)F",5.339,3,1,2]
["S7674","Savolitinib (AZD6094)","f11","L3900-26","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.",345.36,"1313725-88-0",{"v":16,"d":"16.00"},46.33,"<1","N/A","http://selleckchem.com/products/hmpl-504-azd6094-volitinib.html","C17H15N9","free base","HMPL-504, Volitinib","CC([N]1N=NC2=NC=C(N=C12)C3=C[N](C)N=C3)C4=C[N]5C=CN=C5C=C4",1.032,6,0,3]
["S7678","Sacubitril/valsartan (LCZ696)","g11","L3900-26","in 10mM DMSO","Angiotensin Receptor,Apoptosis related,Neprilysin","Proteases","Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.",915.98,"936623-90-4",{"v":30,"d":"30.00"},32.75,{"v":100,"d":"100.00"},109.17,"http://selleckchem.com/products/lcz696.html","C24H29N5O3.C24H29NO5.5/2H2O.3Na","Sodium salt hydrate","Sacubitril, Valsartan","[Na+].[Na+].[Na+].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[NH]3)C(C(C)C)C(O)=O.CCOC(=O)C(C)CC(CC4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)CCC(O)=O",8.591,9,2,22]
["S7684","Salirasib","h11","L3900-26","in 10mM DMSO","Autophagy,PPMTase,Ras","Cell Cycle","Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.",358.54,"162520-00-5","The physical form of the compound is fat, and can be dissolved in any proportion in DMSO","N/A","N/A","N/A","http://selleckchem.com/products/salirasib.html","C22H30O2S","free base","Farnesylthiosalicylic acid, FTS","CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC1=CC=CC=C1C(O)=O",{"v":7.12,"d":"7.120"},1,0,10]
["S7686","ML141","a2","L3900-27","in 10mM DMSO","Apoptosis related,p38 MAPK,Rho","Cell Cycle","ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.",407.49,"71203-35-5",{"v":81,"d":"81.00"},198.78,"<1","N/A","http://selleckchem.com/products/ml141.html","C22H21N3O3S","free base","CID-2950007","COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)[S](N)(=O)=O)C4=CC=CC=C4",{"v":3.87,"d":"3.870"},4,1,5]
["S7691","PS-1145","b2","L3900-27","in 10mM DMSO","IκB/IKK","NF-κB","PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.",322.75,"431898-65-6",{"v":64,"d":"64.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://selleckchem.com/products/ps-1145.html","C17H11ClN4O","free base","N/A","ClC1=CC(=C2[NH]C3=C(C=CN=C3)C2=C1)NC(=O)C4=CN=CC=C4",2.471,3,2,2]
["S7693","Ceralasertib (AZD6738)","c2","L3900-27","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2.",412.51,"1352226-88-0",{"v":82,"d":"82.00"},198.78,"<1","N/A","http://selleckchem.com/products/azd6738.html","C20H24N6O2S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=N)=O)C4=C5C=C[NH]C5=NC=C4",2.427,5,1,4]
["S7694","AZD8186","d2","L3900-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.",457.47,"1627494-13-6",{"v":91,"d":"91.00"},198.92,"<1","N/A","http://selleckchem.com/products/azd8186.html","C24H25F2N3O4","free base","N/A","CC(NC1=CC(=CC(=C1)F)F)C2=CC(=CC3=C2OC(=CC3=O)N4CCOCC4)C(=O)N(C)C",3.418,4,1,5]
["S7704","LY2584702 Tosylate","e2","L3900-27","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.",617.62,"1082949-68-5",{"v":7,"d":"7.00"},11.33,"<1","N/A","http://selleckchem.com/products/ly2584702-tosylate.html","C28H27F4N7O3S","free base","N/A","C[N]1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=N[NH]4)C5=CC(=C(F)C=C5)C(F)(F)F.CC6=CC=C(C=C6)[S](O)(=O)=O",5.829,4,1,5]
["S7707","Verdinexor (KPT-335)","f2","L3900-27","in 10mM DMSO","CRM1","Transmembrane Transporters","Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.",442.32,"1392136-43-4",{"v":88,"d":"88.00"},198.95,"<1","N/A","http://selleckchem.com/products/verdinexor-kpt-335.html","C18H12F6N6O","free base","ATG-527","FC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)C2=N[N](\\C=C/C(=O)NNC3=CC=CC=N3)C=N2",3.496,4,2,7]
["S7721","Monomethyl auristatin E (MMAE)","g2","L3900-27","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .",717.98,"474645-27-7",{"v":100,"d":"100.00"},139.28,"<1","N/A","http://selleckchem.com/products/monomethyl-auristatin-e-mmae.html","C39H67N5O7","free base","SGD-1010","CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C)C(O)C2=CC=CC=C2)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C",{"v":3.46,"d":"3.460"},6,4,20]
["S7723","PRIMA-1","h2","L3900-27","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7724","Eprenetapopt (APR-246)","a3","L3900-27","in 10mM DMSO","Apoptosis related,Autophagy,p53","Apoptosis","Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.",199.25,"5291-32-7",{"v":40,"d":"40.00"},200.75,"N/A","N/A","http://selleckchem.com/products/apr-246-prima-1met.html","C10H17NO3","free base","PRIMA-1MET","COCC1(CO)N2CCC(CC2)C1=O",-0.364,2,1,3]
["S7725","BLZ945","b3","L3900-27","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","BLZ945(Sotuletinib) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.",398.48,"953769-46-5",{"v":79,"d":"79.00"},198.25,"<1","N/A","http://selleckchem.com/products/blz945.html","C20H22N4O3S","free base","Sotuletinib","CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(NC4CCCCC4O)S3",3.201,4,3,5]
["S7730","NU1025","c3","L3900-27","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NU1025 (NSC 696807) is a potent PARP inhibitor with IC50 of 400 nM.",176.17,"90417-38-2",{"v":35,"d":"35.00"},198.67,"<1","N/A","http://selleckchem.com/products/nu1025.html","C9H8N2O2","free base","NSC 696807","CC1=NC2=C(C=CC=C2O)C(=O)N1",0.587,2,2,0]
["S7731","AZD3839","d3","L3900-27","in 10mM DMSO","BACE","Neuronal Signaling","AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.",431.41,"1227163-84-9",{"v":86,"d":"86.00"},199.35,"<1","N/A","http://selleckchem.com/products/azd3839.html","C24H16F3N5","free base","N/A","NC1=NC(C2=CC=CC(=C2)C3=CN=CN=C3)(C4=CC(=NC=C4)C(F)F)C5=CC=CC(=C15)F",3.574,4,1,4]
["S7732","ISO-1","e3","L3900-27","in 10mM DMSO","MIF","Immunology & Inflammation","ISO-1 (MIF Antagonist) is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.",235.24,"478336-92-4",{"v":47,"d":"47.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/iso-1.html","C12H13NO4","free base","MIF Antagonist","COC(=O)CC1CC(=NO1)C2=CC=C(O)C=C2",1.352,4,1,4]
["S7734","LFM-A13","f3","L3900-27","in 10mM DMSO","BTK","Angiogenesis","LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM, >100-fold selectivity over other protein kinases including JAK1, JAK2, HCK, EGFR,and IRK.",{"v":360,"d":"360.00"},"244240-24-2",{"v":72,"d":"72.00"},{"v":200,"d":"200.00"},"<1","N/A","http://selleckchem.com/products/lfm-a13.html","C11H8Br2N2O2","free base","N/A","C/C(O)=C(C#N)/C(=O)NC1=C(Br)C=CC(=C1)Br",2.645,1,2,2]
["S7738","PRT-060318 2HCl","g3","L3900-27","in 10mM DMSO","Syk","Angiogenesis","PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.",413.34,"1194961-19-7 (free base)",{"v":75,"d":"75.00"},181.45,{"v":75,"d":"75.00"},181.45,"http://selleckchem.com/products/prt-060318-prt318-3hcl.html","C18H24N6O.2HCl","Dihydrochloride","PRT318","Cl.Cl.CC1=CC(=CC=C1)NC2=C(C=NC(=N2)NC3CCCCC3N)C(N)=O",3.706,3,4,5]
["S7741","SB239063","h3","L3900-27","in 10mM DMSO","p38 MAPK","MAPK","SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.",{"v":368.4,"d":"368.40"},"193551-21-2",{"v":60,"d":"60.00"},162.87,"<1","N/A","http://selleckchem.com/products/sb239063.html","C20H21FN4O2","free base","N/A","COC1=NC=CC(=N1)C2=C(N=C[N]2C3CCC(O)CC3)C4=CC=C(F)C=C4",3.661,4,1,4]
["S7748","EPZ015666 (GSK3235025)","a4","L3900-27","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.",383.44,"1616391-65-1",{"v":60,"d":"60.00"},156.48,"<1","N/A","http://selleckchem.com/products/epz015666.html","C20H25N5O3","free base","GSK3235025","OC(CNC(=O)C1=CC(=NC=N1)NC2COC2)CN3CCC4=C(C3)C=CC=C4",1.038,4,3,7]
["S7750","KNK437","b4","L3900-27","in 10mM DMSO","HSP (HSP90)","Cell Cycle","KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.",245.23,"218924-25-5",{"v":15,"d":"15.00"},61.17,"<1","N/A","http://selleckchem.com/products/knk437.html","C13H11NO4","free base","N/A","O=CN1CCC(=C/C2=CC3=C(OCO3)C=C2)/C1=O",{"v":1.22,"d":"1.220"},4,0,1]
["S7754","Gilteritinib (ASP2215)","c4","L3900-27","in 10mM DMSO","Axl,FLT3","Protein Tyrosine Kinase","Gilteritinib (ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).",552.71,"1254053-43-4",{"v":100,"d":"100.00"},180.93,"<1","N/A","http://selleckchem.com/products/gilteritinib-asp2215.html","C29H44N8O3","free base","N/A","CCC1=NC(=C(NC2=CC=C(N3CCC(CC3)N4CCN(C)CC4)C(=C2)OC)N=C1NC5CCOCC5)C(N)=O",2.401,5,3,9]
["S7757","6-Thio-dG","d4","L3900-27","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.",283.31,"789-61-7",{"v":56,"d":"56.00"},197.66,"<1","N/A","http://selleckchem.com/products/6-thio-dg.html","C10H13N5O3S","free base","β-TGdR","NC1=NC(=S)C2=C(N1)[N](C=N2)C3CC(O)C(CO)O3",-0.714,3,4,2]
["S7762","TRx0237 (LMTX) mesylate","e4","L3900-27","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.",477.62,"1236208-20-0",{"v":95,"d":"95.00"},{"v":198.9,"d":"198.90"},{"v":95,"d":"95.00"},{"v":198.9,"d":"198.90"},"http://selleckchem.com/products/trx0237-lmtx-mesylate.html","C16H19N3S.2CH4O3S","Dimesylate","Hydromethylthionine mesylate","C[NH+](C)C1=CC=C2NC3=C(SC2=C1)C=C(C=C3)[NH+](C)C.C[S]([O-])(=O)=O.C[S]([O-])(=O)=O",-4.637,0,1,2]
["S7765","Dovitinib (TKI258) Lactate monohydrate","f4","L3900-27","in 10mM DMSO","c-Kit,FGFR,FLT3,PDGFR,VEGFR","Angiogenesis","Dovitinib (TKI258) Lactate monohydrate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.",500.52,"915769-50-5 (monohydrate)",{"v":100,"d":"100.00"},207.25,{"v":66,"d":"66.00"},136.78,"http://selleckchem.com/products/dovitinib-tki258-lactate.html","C24H29FN6O5","Lactate monohydrate","CHIR258","O.CC(O)C(O)=O.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(F)C=CC=C5NC4=O",-1.646,3,4,3]
["S7766","Cabotegravir (GSK1265744)","g4","L3900-27","in 10mM DMSO","Integrase","Microbiology","Cabotegravir (GSK744, GSK1265744, S/GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.",405.35,"1051375-10-0",{"v":38,"d":"38.00"},93.75,"<1","N/A","http://selleckchem.com/products/cabotegravir-gsk744-gsk1265744.html","C19H17F2N3O5","free base","GSK744, S/GSK1265744","CC1COC2CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(=C3C(=O)N12)O",0.237,4,2,3]
["S7772","Elacridar (GF120918)","h4","L3900-27","in 10mM DMSO","P-gp","Transmembrane Transporters","Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.",563.64,"143664-11-3",{"v":8,"d":"8.00"},14.19,"<1","N/A","http://selleckchem.com/products/elacridar-gf120918.html","C34H33N3O5","free base","GW120918, GG918, GW0918","COC1=C2NC3=C(C=CC=C3C(=O)NC4=CC=C(CCN5CCC6=C(C5)C=C(OC)C(=C6)OC)C=C4)C(=O)C2=CC=C1",5.742,5,2,8]
["S7775","Emricasan (IDN-6556)","a5","L3900-27","in 10mM DMSO","Antiviral,Caspase","Apoptosis","Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.",{"v":569.5,"d":"569.50"},"254750-02-2",{"v":100,"d":"100.00"},175.59,"<1","N/A","http://selleckchem.com/products/emricasan-idn-6556-pf-03491390.html","C26H27F4N3O7","free base","PF 03491390, PF-03491390","CC(NC(=O)C(=O)NC1=C(C=CC=C1)C(C)(C)C)C(=O)NC(CC(O)=O)C(=O)COC2=C(F)C(=CC(=C2F)F)F",3.017,6,3,12]
["S7777","Coelenterazine","b5","L3900-27","in 10mM DMSO","Dyes","Others","Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.",423.46,"55779-48-1",{"v":84,"d":"84.00"},198.37,"<1","N/A","http://selleckchem.com/products/coelenterazine.html","C26H21N3O3","free base","N/A","OC1=CC=C(CC2=NC3=C(CC4=CC=CC=C4)NC(=CN3C2=O)C5=CC=C(O)C=C5)C=C1",3.404,2,3,5]
["S7781","Sunitinib (SU11248)","c5","L3900-27","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1","N/A","http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7782","Dasatinib Monohydrate","d5","L3900-27","in 10mM DMSO","Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib Monohydrate (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.",506.02,"863127-77-9",{"v":21,"d":"21.00"},{"v":41.5,"d":"41.50"},"<1","N/A","http://selleckchem.com/products/dasatinib-monohydrate.html","C22H28ClN7O3S","Monohydrate","BMS-354825 Monohydrate","O.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.232,4,3,7]
["S7783","Combretastatin A4","e5","L3900-27","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.",316.35,"117048-59-6",{"v":63,"d":"63.00"},199.15,"<1","N/A","http://selleckchem.com/products/combretastatin-a4.html","C18H20O5","free base","N/A","COC1=C(O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",3.508,4,1,6]
["S7784","Fumagillin","f5","L3900-27","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics","Microbiology","Fumagillin(Amebacilin,NSC9168) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.",458.54,"23110-15-8",{"v":92,"d":"92.00"},200.64,"<1","N/A","http://selleckchem.com/products/fumagillin.html","C26H34O7","free base","Amebacilin,NSC9168","COC1C(CCC2(CO2)C1C3(C)OC3CC=C(C)C)OC(=O)\\C=C\\C=C\\C=C\\C=C\\C(O)=O",3.421,6,0,11]
["S7786","Erlotinib (OSI-774)","g5","L3900-27","in 10mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.",393.44,"183321-74-6",{"v":78,"d":"78.00"},198.25,"<1","N/A","http://selleckchem.com/products/erlotinib.html","C22H23N3O4","free base","CP358774, NSC 718781, Tarceva","COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.309,6,1,10]
["S7787","Docetaxel Trihydrate","h5","L3900-27","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",861.93,"148408-66-6",{"v":100,"d":"100.00"},116.02,"<1","N/A","http://selleckchem.com/products/docetaxel-trihydrate.html","C43H53NO14.3H2O","Trihydrate","RP56976 (NSC 628503) Trihydrate","O.O.O.CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",1.964,10,4,13]
["S7792","SRT2104 (GSK2245840)","a6","L3900-27","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.",516.64,"1093403-33-8",{"v":16,"d":"16.00"},30.97,"<1","N/A","http://selleckchem.com/products/srt2104-gsk2245840.html","C26H24N6O2S2","free base","N/A","CC1=C(SC(=N1)C2=CC=CN=C2)C(=O)NC3=C(C=CC=C3)C4=C[N]5C(=CSC5=N4)CN6CCOCC6",2.813,5,1,6]
["S7795","Iadademstat (ORY-1001) 2HCl","b6","L3900-27","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.",303.27,"1431326-61-2",{"v":5,"d":"5.00"},16.49,{"v":61,"d":"61.00"},201.14,"http://selleckchem.com/products/ory-1001-rg-6016.html","C15H22N2.2HCl","dihydrochloride","RG-6016","Cl.Cl.NC1CCC(CC1)NC2CC2C3=CC=CC=C3",2.721,0,2,3]
["S7796","GSK2879552 2HCl","c6","L3900-27","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.",{"v":437.4,"d":"437.40"},"1902123-72-1",{"v":29,"d":"29.00"},{"v":66.3,"d":"66.30"},{"v":44,"d":"44.00"},100.59,"http://selleckchem.com/products/gsk2879552-2hcl.html","C23H28N2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OC(=O)C1=CC=C(CN2CCC(CC2)CNC3CC3C4=CC=CC=C4)C=C1",1.586,1,1,7]
["S7799","Pexmetinib (ARRY-614)","d6","L3900-27","in 10mM DMSO","p38 MAPK,Tie-2","MAPK","Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor  with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.",556.63,"945614-12-0",{"v":100,"d":"100.00"},179.65,"<1","N/A","http://selleckchem.com/products/pexmetinib-arry-614.html","C31H33FN6O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NCC3=C(OC4=CC5=C(C=C4)[N](CCO)N=C5)C=CC(=C3)F)C(C)(C)C",6.271,4,3,9]
["S7808","AT7519 HCl","e6","L3900-27","in 10mM DMSO","CDK","Cell Cycle","AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.",418.71,"902135-91-5",{"v":52,"d":"52.00"},124.19,{"v":43,"d":"43.00"},{"v":102.7,"d":"102.70"},"http://selleckchem.com/products/at7519-hcl.html","C16H18Cl3N5O2","Hydrochloride","N/A","Cl.ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",{"v":1.98,"d":"1.980"},3,4,4]
["S7810","Afatinib (BIBW2992) Dimaleate","f6","L3900-27","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.",717.18,"850140-73-7",{"v":100,"d":"100.00"},139.44,"<1","N/A","http://selleckchem.com/products/afatinib-bibw2992-dimaleate.html","C24H25ClFN5O3.2C4H4O4","Dimaleate","N/A","CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",{"v":0.96,"d":"0.960"},9,2,12]
["S7812","Itacitinib (INCB39110)","g6","L3900-27","in 10mM DMSO","JAK","JAK/STAT","Itacitinib(INCB39110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.",553.51,"1334298-90-6",{"v":100,"d":"100.00"},180.67,"<1","N/A","http://selleckchem.com/products/itacitinib-incb39110.html","C26H23F4N9O","free base","N/A","FC1=C(C=CN=C1C(F)(F)F)C(=O)N2CCC(CC2)N3CC(CC#N)(C3)[N]4C=C(C=N4)C5=C6C=C[NH]C6=NC=N5",2.422,5,1,6]
["S7813","AMG319","h6","L3900-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.",{"v":385.4,"d":"385.40"},"1608125-21-8",{"v":77,"d":"77.00"},199.79,"<1","N/A","http://selleckchem.com/products/amg319.html","C21H16FN7","free base","N/A","CC(NC1=C2N=C[NH]C2=NC=N1)C3=C(N=C4C=C(F)C=CC4=C3)C5=CC=CC=N5",3.691,5,2,4]
["S7816","MI-463","a7","L3900-27","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.",484.54,"1628317-18-9",{"v":96,"d":"96.00"},198.13,"<1","N/A","http://selleckchem.com/products/mi-463.html","C24H23F3N6S","free base","N/A","CC1=C2C=C([NH]C2=CC=C1CN3CCC(CC3)NC4=C5C=C(CC(F)(F)F)SC5=NC=N4)C#N",5.372,2,2,6]
["S7818","Pexidartinib (PLX3397)","b7","L3900-27","in 10mM DMSO","Apoptosis related,c-Kit,CSF-1R,FLT3","Protein Tyrosine Kinase","Pexidartinib (PLX3397) is an oral, potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit (c-Kit), and FLT3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Pexidartinib (PLX3397) induces apoptosis and necrosis with antitumor activity. Phase 3.",417.81,"1029044-16-3",{"v":83,"d":"83.00"},198.65,"<1","N/A","http://selleckchem.com/products/pexidartinib-plx3397.html","C20H15ClF3N5","free base","N/A","FC(F)(F)C1=NC=C(CNC2=NC=C(CC3=C[NH]C4=NC=C(Cl)C=C34)C=C2)C=C1",4.811,3,2,6]
["S7820","EPZ020411 2HCl","c7","L3900-27","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM.",515.52,"2070015-25-5",{"v":100,"d":"100.00"},193.98,{"v":81,"d":"81.00"},157.12,"http://selleckchem.com/products/epz020411.html","C25H40Cl2N4O3","dihydrochloride","N/A","Cl.Cl.CNCCN(C)CC1=C[NH]N=C1C2=CC=C(OC3CC(C3)OCCC4CCOCC4)C=C2",3.322,4,2,12]
["S7824","Nazartinib (EGF816)","d7","L3900-27","in 10mM DMSO","EGFR","Angiogenesis","Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.",495.02,"1508250-71-2",{"v":99,"d":"99.00"},199.99,"<1","N/A","http://selleckchem.com/products/nazartinib-egf816-nvs-816.html","C26H31ClN6O2","free base","NVS-816","CN(C)C/C=C/C(=O)N1CCCCC(C1)[N]2C(=NC3=CC=CC(=C23)Cl)NC(=O)C4=CC(=NC=C4)C",3.705,4,1,6]
["S7827","4-Hydroxytamoxifen (Afimoxifene)","e7","L3900-27","in 10mM DMSO","CRISPR/Cas9,Estrogen/progestogen Receptor","Endocrinology & Hormones","4-Hydroxytamoxifen (Afimoxifene)  is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants.",387.51,"68392-35-8",{"v":77,"d":"77.00"},{"v":198.7,"d":"198.70"},"<1","N/A","http://selleckchem.com/products/4-hydroxytamoxifen-4-ht-afimoxifene.html","C26H29NO2","free base","Afimoxifene","CCC(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)C3=CC=C(OCCN(C)C)C=C3",6.077,1,1,8]
["S7828","Licochalcone A","f7","L3900-27","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.",{"v":338.4,"d":"338.40"},"58749-22-7",{"v":67,"d":"67.00"},197.99,"<1","N/A","http://selleckchem.com/products/licochalcone-a.html","C21H22O4","free base","N/A","COC1=C(/C=C/C(=O)C2=CC=C(O)C=C2)C=C(C(=C1)O)C(C)(C)C=C",4.667,2,2,6]
["S7829","CB1954","g7","L3900-27","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.",252.18,"21919-05-1",{"v":50,"d":"50.00"},198.27,"<1","N/A","http://selleckchem.com/products/cb1954.html","C9H8N4O5","free base","Tretazicar, NSC 115829","NC(=O)C1=C(C=C(C(=C1)N2CC2)[N+]([O-])=O)[N+]([O-])=O",0.601,1,1,4]
["S7839","Endoxifen HCl","h7","L3900-27","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.",409.95,"1032008-74-4",{"v":74,"d":"74.00"},180.51,"<1","N/A","http://selleckchem.com/products/endoxifen-hcl.html","C25H28ClNO2","Hydrochloride","N/A","Cl.CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCNC)C=C3",5.923,1,2,8]
["S7843","BI-847325","a8","L3900-27","in 10mM DMSO","Aurora Kinase,MEK","MAPK","BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.",464.56,"1207293-36-4",{"v":19,"d":"19.00"},{"v":40.9,"d":"40.90"},"<1","N/A","http://selleckchem.com/products/bi-847325.html","C29H28N4O2","free base","N/A","CCNC(=O)C#CC1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4",4.041,2,3,8]
["S7852","Eliglustat","b8","L3900-27","in 10mM DMSO","Glucosylceramide Synthase","Metabolism","Eliglustat (GENZ-112638) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.",404.54,"491833-29-5",{"v":80,"d":"80.00"},197.76,"<1","N/A","http://selleckchem.com/products/eliglustat.html","C23H36N2O4","Tartrate","GENZ-112638","CCCCCCCC(=O)NC(CN1CCCC1)C(O)C2=CC=C3OCCOC3=C2",3.808,3,2,11]
["S7854","Ulixertinib (BVD-523)","c8","L3900-27","in 10mM DMSO","ERK","MAPK","Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.",433.33,"869886-67-9",{"v":86,"d":"86.00"},198.46,"<1","N/A","http://selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html","C21H22Cl2N4O2","free base","VRT752271","CC(C)NC1=NC=C(Cl)C(=C1)C2=C[NH]C(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl",4.266,2,4,7]
["S7855","Brilanestrant (GDC-0810)","d8","L3900-27","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Brilanestrant (GDC-0810, ARN-810） is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.",{"v":446.9,"d":"446.90"},"1365888-06-7",{"v":89,"d":"89.00"},199.15,"<1","N/A","http://selleckchem.com/products/brilanestrant-gdc-0810-arn-810.html","C26H20ClFN2O2","free base","ARN-810","CCC(\\C1=CC=C(F)C=C1Cl)=C(C2=CC=C(\\C=C\\C(O)=O)C=C2)/C3=CC4=C([NH]N=C4)C=C3",6.808,2,1,6]
["S7856","Tenofovir Alafenamide (GS-7340)","e8","L3900-27","in 10mM DMSO","Reverse Transcriptase","Microbiology","Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.",476.47,"379270-37-8",{"v":95,"d":"95.00"},199.38,"<1","N/A","http://selleckchem.com/products/tenofovir-alafenamide-gs-7340.html","C21H29N6O5P","free base","N/A","CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C1N=CN=C2N)OC3=CC=CC=C3",1.526,8,2,12]
["S7864","Oltipraz","f8","L3900-27","in 10mM DMSO","Nrf2","Immunology & Inflammation","Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.",226.34,"64224-21-1",{"v":39,"d":"39.00"},172.31,"<1","N/A","http://selleckchem.com/products/oltipraz.html","C8H6N2S3","free base","N/A","CC1=C(SSC1=S)C2=NC=CN=C2",2.225,2,0,1]
["S7875","NVP-CGM097","g8","L3900-27","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7883","BQ-123","h8","L3900-27","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.",{"v":610.7,"d":"610.70"},"136553-81-6",{"v":100,"d":"100.00"},163.75,"<1","N/A","http://selleckchem.com/products/bq-123.html","C31H42N6O7","free base","N/A","CC(C)CC1NC(=O)C(NC(=O)C2CCCN2C(=O)C(CC(O)=O)NC(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC1=O)C(C)C",1.343,6,5,7]
["S7886","Onatasertib (CC 223)","a9","L3900-27","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.",397.47,"1228013-30-6",{"v":79,"d":"79.00"},198.76,"<1","N/A","http://selleckchem.com/products/cc-223.html","C21H27N5O3","free base","ATG-008","COC1CCC(CC1)N2C(=O)CNC3=NC=C(N=C23)C4=CN=C(C=C4)C(C)(C)O",{"v":1.66,"d":"1.660"},5,1,4]
["S7889","Xanthohumol","b9","L3900-27","in 10mM DMSO","Acyltransferase,Apoptosis related,CMV,COX","Metabolism","Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.",{"v":354.4,"d":"354.40"},"6754-58-1",{"v":70,"d":"70.00"},197.52,"<1","N/A","http://selleckchem.com/products/xanthohumol.html","C21H22O5","free base","N/A","COC1=C(C(=C(CC=C(C)C)C(=C1)O)O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.816,2,3,6]
["S7891","CC-115","c9","L3900-27","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.",336.35,"1228013-15-7",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cc-115.html","C16H16N8O","free base","N/A","CCN1C(=O)CNC2=NC=C(N=C12)C3=C(C)N=C(C=C3)C4=N[NH]C=N4",0.664,6,2,3]
["S7892","Avadomide (CC-122)","d9","L3900-27","in 10mM DMSO","E3 Ligase ,Immunology & Inflammation related","Ubiquitin","Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.",286.29,"1015474-32-4",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/cc-122.html","C14H14N4O3","Free Base","N/A","CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N",-0.477,4,2,1]
["S7896","Sodium Tauroursodeoxycholate (TUDC)","e9","L3900-27","in 10mM DMSO","Anti-infection","Microbiology","Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.",521.69,"35807-85-3",{"v":100,"d":"100.00"},191.68,{"v":100,"d":"100.00"},191.68,"http://selleckchem.com/products/sodium-tauroursodeoxycholate-tudc.html","C26H44NNaO6S","sodium salt","N/A","CC(CCC(=O)NCC[S](=O)(=O)O[Na])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",3.088,2,3,8]
["S7910","Epacadostat (INCB024360)","f9","L3900-27","in 10mM DMSO","IDO/TDO","Metabolism","Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).",438.23,"1204669-58-8",{"v":87,"d":"87.00"},198.53,"<1","N/A","http://selleckchem.com/products/epacadostat-incb024360.html","C11H13BrFN7O4S","free base","N/A","N[S](=O)(=O)NCCNC1=NON=C1C(NO)=NC2=CC(=C(F)C=C2)Br",0.378,6,4,8]
["S7917","Kenpaullone","g9","L3900-27","in 10mM DMSO","CDK","Cell Cycle","Kenpaullone (9-Bromopaullone, NSC-664704) is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.",327.18,"142273-20-9",{"v":65,"d":"65.00"},198.67,"<1","N/A","http://selleckchem.com/products/kenpaullone.html","C16H11BrN2O","free base","9-Bromopaullone, NSC-664704","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3C=CC=C4)C=C1",3.671,1,2,0]
["S7918","Bromodeoxyuridine (BrdU)","h9","L3900-27","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bromodeoxyuridine (BrdU, 5-Bromo-2'-deoxyuridine, BUdR) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.",{"v":307.1,"d":"307.10"},"59-14-3",{"v":61,"d":"61.00"},198.63,"<1","N/A","http://selleckchem.com/products/bromodeoxyuridine-brdu.html","C9H11BrN2O5","free base","5-Bromo-2'-deoxyuridine, BUdR","OCC1OC(CC1O)N2C=C(Br)C(=O)NC2=O",-1.232,3,3,2]
["S7922","Tiplaxtinin (PAI-039)","a10","L3900-27","in 10mM DMSO","PAI-1","Metabolism","Tiplaxtinin(PAI-039) is an orally efficacious and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 μM.",439.38,"393105-53-8",{"v":72,"d":"72.00"},163.87,"<1","N/A","http://selleckchem.com/products/tiplaxtinin-pai-039.html","C24H16F3NO4","free base","N/A","OC(=O)C(=O)C1=C[N](CC2=CC=CC=C2)C3=CC=C(C=C13)C4=CC=C(OC(F)(F)F)C=C4",7.066,3,0,7]
["S7931","STF-31","b10","L3900-27","in 10mM DMSO","GLUT","Metabolism","STF-31 is a selective glucose transporter GLUT1 inhibitor.",423.53,"724741-75-7",{"v":85,"d":"85.00"},200.69,"<1","N/A","http://selleckchem.com/products/stf-31.html","C23H25N3O3S","free base","N/A","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3",3.359,4,2,7]
["S7935","Y-39983 HCl","c10","L3900-27","in 10mM DMSO","ROCK","Cell Cycle","Y-39983 HCl (Y-33075) is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.",353.25,"173897-44-4",{"v":63,"d":"63.00"},178.34,{"v":63,"d":"63.00"},178.34,"http://selleckchem.com/products/y-39983-hcl.html","C16H16N4O.2HCl","dihydrochloride","Y-33075 HCl","Cl.Cl.CC(N)C1=CC=C(C=C1)C(=O)NC2=C3C=C[NH]C3=NC=C2",2.204,2,3,3]
["S7936","Belumosudil (KD025)","d10","L3900-27","in 10mM DMSO","ROCK","Cell Cycle","Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.",452.51,"911417-87-3",{"v":90,"d":"90.00"},198.89,"<1","N/A","http://selleckchem.com/products/kd025-(slx-2119).html","C26H24N6O2","free base","SLx-2119","CC(C)NC(=O)COC1=CC(=CC=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C([NH]N=C5)C=C4",{"v":4.51,"d":"4.510"},5,3,7]
["S7937","Nemiralisib","e10","L3900-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).",440.54,"1254036-71-9",{"v":88,"d":"88.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk2269557.html","C26H28N6O","free base","GSK2269557","CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=CC(=CC4=C3C=N[NH]4)C5=CC=CC6=C5C=C[NH]6",3.943,3,2,5]
["S7938","GSK2292767","f10","L3900-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GSK2292767 is a potent and selective PI3Kδ inhibitor.",512.58,"1254036-66-2",{"v":100,"d":"100.00"},195.09,"<1","N/A","http://selleckchem.com/products/gsk2292767.html","C24H28N6O5S","free base","N/A","COC1=C(N[S](C)(=O)=O)C=C(C=N1)C2=CC3=C(C=N[NH]3)C(=C2)C4=NC=C(CN5CC(C)OC(C)C5)O4",1.692,8,2,7]
["S7947","PX-12","g10","L3900-27","in 10mM DMSO","COVID-19,Thioredoxin","Metabolism","PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent thioredoxin-1 (Trx-1) inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.",188.31,"141400-58-0",{"v":38,"d":"38.00"},201.79,"<1","N/A","http://selleckchem.com/products/px-12.html","C7H12N2S2","free base","DB05448, 1-methyl propyl 2-imidazolyl disulfide","CCC(C)SSC1=NC=C[NH]1",2.641,1,1,4]
["S7952","Ozanimod (RPC1063)","h10","L3900-27","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.",404.46,"1306760-87-1",{"v":81,"d":"81.00"},200.27,"<1","N/A","http://selleckchem.com/products/ozanimod-rpc1063.html","C23H24N4O3","free base","N/A","CC(C)OC1=CC=C(C=C1C#N)C2=NC(=NO2)C3=CC=CC4=C3CCC4NCCO",3.291,4,2,7]
["S7953","ETC-1002","a11","L3900-27","in 10mM DMSO","AMPK,ATP-citrate lyase,LDL","PI3K/Akt/mTOR","ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).",344.49,"738606-46-7",{"v":68,"d":"68.00"},197.39,"<1","N/A","http://selleckchem.com/products/etc-1002.html","C19H36O5","free base","Bempedoic acid, ESP-55016","CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O",{"v":5.18,"d":"5.180"},2,1,14]
["S7955","EPI-001","b11","L3900-27","in 10mM DMSO","Androgen Receptor,PPAR","Endocrinology & Hormones","EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.",394.89,"227947-06-0",{"v":79,"d":"79.00"},200.06,"<1","N/A","http://selleckchem.com/products/epi-001.html","C21H27ClO5","free base","N/A","CC(C)(C1=CC=C(OCC(O)CO)C=C1)C2=CC=C(OCC(O)CCl)C=C2",3.334,2,3,10]
["S7960","Larotrectinib (LOXO-101) sulfate","c11","L3900-27","in 10mM DMSO","Apoptosis related,Trk receptor","Protein Tyrosine Kinase","Larotrectinib sulfate (LOXO-101, ARRY-470) is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). Larotrectinib inhibition of TRKs induces cellular apoptosis and G1 cell-cycle arrest.",526.51,"1223405-08-0",{"v":100,"d":"100.00"},189.93,"<1","N/A","http://selleckchem.com/products/loxo-101.html","C21H22F2N6O2.H2SO4","sulfate","ARRY-470, Larotrectinib","OC1CCN(C1)C(=O)NC2=C3N=C(C=C[N]3N=C2)N4CCCC4C5=CC(=CC=C5F)F.O[S](O)(=O)=O",1.374,3,2,3]
["S7963","TIC10 (ONC201)","d11","L3900-27","in 10mM DMSO","Akt,Apoptosis related,ERK,TNF-alpha","PI3K/Akt/mTOR","TIC10 (ONC201) inactivates Akt and ERK to induce TNF-related apoptosis-inducing ligand (TRAIL) through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"1616632-77-9",{"v":77,"d":"77.00"},199.23,"<1","N/A","http://selleckchem.com/products/tic-10.html","C24H26N4O","free base","ONC201","CC1=CC=CC=C1CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25",3.212,2,0,4]
["S7965","PLX8394","e11","L3900-27","in 10mM DMSO","Raf","MAPK","PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.",542.53,"1393466-87-9",{"v":100,"d":"100.00"},184.32,"<1","N/A","http://www.selleckchem.com/products/plx8394.html","C25H21F3N6O3S","Free Base","N/A","FC1CCN(C1)[S](=O)(=O)NC2=CC=C(F)C(=C2F)C(=O)C3=C[NH]C4=NC=C(C=C34)C5=CN=C(N=C5)C6CC6",2.252,6,2,7]
["S7966","AZD8835","f11","L3900-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).",469.54,"1620576-64-8",{"v":93,"d":"93.00"},198.07,"<1","N/A","http://selleckchem.com/products/azd8835.html","C22H31N9O3","free base","N/A","CC[N]1N=C(N=C1C2=CN=C(N)C(=N2)C3=NN=C(O3)C(C)(C)C)C4CCN(CC4)C(=O)CCO",0.942,8,2,7]
["S7968","P7C3","g11","L3900-27","in 10mM DMSO","NAMPT","Metabolism","P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.",474.19,"301353-96-8",{"v":95,"d":"95.00"},200.34,"<1","N/A","http://selleckchem.com/products/p7c3.html","C21H18Br2N2O","free base","N/A","OC(CNC1=CC=CC=C1)C[N]2C3=C(C=C(Br)C=C3)C4=C2C=CC(=C4)Br",5.972,0,2,5]
["S7971","Zorifertinib (AZD3759)","h11","L3900-27","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Zorifertinib (AZD3759) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. Phase 1.",{"v":459.9,"d":"459.90"},"1626387-80-1",{"v":91,"d":"91.00"},197.87,"<1","N/A","http://selleckchem.com/products/azd3759.html","C22H23ClFN5O3","free base","N/A","COC1=C(OC(=O)N2CCN(C)CC2C)C=C3C(=NC=NC3=C1)NC4=CC=CC(=C4F)Cl",4.635,5,1,5]
["S7974","L755507","a2","L3900-28","in 10mM DMSO","Adrenergic Receptor,CRISPR/Cas9","GPCR & G Protein","L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.",584.73,"159182-43-1",{"v":100,"d":"100.00"},171.02,"<1","N/A","http://selleckchem.com/products/l755507.html","C30H40N4O6S","free base","N/A","CCCCCCNC(=O)NC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(CCNCC(O)COC3=CC=C(O)C=C3)C=C2",4.413,4,6,17]
["S7975","Favipiravir (T-705)","b2","L3900-28","in 10mM DMSO","COVID-19,DNA/RNA Synthesis,Influenza Virus","DNA Damage/DNA Repair","Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.",{"v":157.1,"d":"157.10"},"259793-96-9",{"v":31,"d":"31.00"},197.33,{"v":5,"d":"5.00"},31.83,"http://selleckchem.com/products/favipiravir-t-705.html","C5H4FN3O2","free base","N/A","NC(=O)C1=NC(=CN=C1O)F",-0.157,3,2,1]
["S7977","Napabucasin (BBI608)","c2","L3900-28","in 10mM DMSO","STAT","JAK/STAT","Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.",240.21,"83280-65-3",{"v":10,"d":"10.00"},41.63,"<1","N/A","http://selleckchem.com/products/napabucasin.html","C14H8O4","free base","BBI608","CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O",2.234,4,0,1]
["S7979","FG-2216","d2","L3900-28","in 10mM DMSO","HIF","Angiogenesis","FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.",280.66,"223387-75-5",{"v":56,"d":"56.00"},199.53,"<1","N/A","http://selleckchem.com/products/fg-2216.html","C12H9ClN2O4","free base","N/A","OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2C(=N1)Cl",1.337,3,2,3]
["S7993","SKF38393 HCl","e2","L3900-28","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.",291.77,"62717-42-4",{"v":58,"d":"58.00"},198.79,"<1","N/A","http://selleckchem.com/products/skf38393-hcl.html","C16H17NO2.HCl","Hydrochloride","N/A","Cl.OC1=C(O)C=C2C(CNCCC2=C1)C3=CC=CC=C3",3.013,0,3,1]
["S7995","Ripasudil (K-115) hydrochloride dihydrate","f2","L3900-28","in 10mM DMSO","ROCK","Cell Cycle","Ripasudil (K-115) hydrochloride dihydrate is a potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.",395.88,"887375-67-9",{"v":26,"d":"26.00"},65.68,{"v":79,"d":"79.00"},199.56,"http://selleckchem.com/products/ripasudil-k-115.html","C15H18FN3O2S.ClH.2H2O","Hydrochloride dihydrate","N/A","O.O.Cl.CC1CNCCCN1[S](=O)(=O)C2=CC=CC3=CN=CC(=C23)F",0.739,3,1,2]
["S7998","Entrectinib (RXDX-101)","g2","L3900-28","in 10mM DMSO","ALK,Autophagy,ROS1,Trk receptor","Protein Tyrosine Kinase","Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.",560.64,"1108743-60-7",{"v":100,"d":"100.00"},178.37,"<1","N/A","http://selleckchem.com/products/entrectinib-rxdx-101.html","C31H34F2N6O2","free base","NMS-E628","CN1CCN(CC1)C2=CC=C(C(=O)NC3=N[NH]C4=C3C=C(CC5=CC(=CC(=C5)F)F)C=C4)C(=C2)NC6CCOCC6",4.952,3,3,7]
["S7999","SKF96365","h2","L3900-28","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8001","Ricolinostat (ACY-1215)","a3","L3900-28","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.",{"v":433.5,"d":"433.50"},"1316214-52-4",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/rocilinostat-acy-1215.html","C24H27N5O3","free base","Rocilinostat","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",3.917,4,2,11]
["S8002","GSK2636771","b3","L3900-28","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3Kβ with >900-fold selectivity over PI3Kα/PI3Kγ and >10-fold over PI3Kδ. Sensitive to PTEN null cell lines.",433.42,"1372540-25-4",{"v":28,"d":"28.00"},{"v":64.6,"d":"64.60"},"<1","N/A","http://selleckchem.com/products/gsk2636771.html","C22H22F3N3O3","free base","N/A","CC1=NC2=C(C=C(C=C2[N]1CC3=CC=CC(=C3C)C(F)(F)F)N4CCOCC4)C(O)=O",4.303,3,0,5]
["S8003","PQ 401","c3","L3900-28","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.",341.79,"196868-63-0",{"v":32,"d":"32.00"},93.62,"<1","N/A","http://selleckchem.com/products/pq-401.html","C18H16ClN3O2","free base","N/A","COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(=C2)C)C=C(Cl)C=C1",3.639,3,2,3]
["S8005","SMI-4a","d3","L3900-28","in 10mM DMSO","Pim","JAK/STAT","SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.",273.23,"438190-29-5",{"v":55,"d":"55.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/smi-4a.html","C11H6F3NO2S","free base","TCS PIM-1 4a","FC(F)(F)C1=CC(=CC=C1)\\C=C2/SC(=O)NC2=O",2.884,2,1,2]
["S8009","AG-18","e3","L3900-28","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG-18 (RG-50810, Tyrphostin A23, TX 825) inhibits EGFR with IC50 of 35 μM.",186.17,"118409-57-7",{"v":37,"d":"37.00"},198.74,"<1","N/A","http://selleckchem.com/products/ag-18-tyrphostin-23.html","C10H6N2O2","free base","RG-50810, Tyrphostin A23, TX 825","OC1=C(O)C=C(C=C1)C=C(C#N)C#N",1.531,0,2,1]
["S8010","PRX-08066 Maleic acid","f3","L3900-28","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.",517.96,"866206-55-5",{"v":104,"d":"104.00"},200.79,{"v":104,"d":"104.00"},200.79,"http://selleckchem.com/products/prx-08066.html","C19H17ClFN5S.C4H4O4","Maleate","N/A","OC(=O)\\C=C/C(O)=O.FC1=CC=C(CN2CCC(CC2)NC3=NC=NC4=C3C=C(Cl)S4)C=C1C#N",0.701,4,1,6]
["S8015","Agerafenib (RXDX-105)","g3","L3900-28","in 10mM DMSO","c-Kit,c-RET,CSF-1R,PDGFR,Raf","MAPK","Agerafenib (RXDX-105, CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.",517.46,"1188910-76-0",{"v":9,"d":"9.00"},17.39,"<1","N/A","http://selleckchem.com/products/cep-32496.html","C24H22F3N5O5","free base","CEP-32496","COC1=CC2=NC=NC(=C2C=C1OC)OC3=CC(=CC=C3)NC(=O)NC4=NOC(=C4)C(C)(C)C(F)(F)F",5.288,8,2,8]
["S8016","Vonoprazan Fumarate (TAK-438)","h3","L3900-28","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.",461.46,"1260141-27-2",{"v":62,"d":"62.00"},134.36,"<1","N/A","http://selleckchem.com/products/tak-438.html","C17H16FN3O2S.C4H4O4","Fumarate","N/A","CNCC1=C[N](C(=C1)C2=CC=CC=C2F)[S](=O)(=O)C3=CC=CN=C3.OC(=O)\\C=C\\C(O)=O",0.017,5,1,7]
["S8018","Nirogacestat (PF-03084014)","a4","L3900-28","in 10mM DMSO","Apoptosis related,Secretase","Proteases","Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.",489.64,"1290543-63-3",{"v":97,"d":"97.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pf-03084014-pf-3084014.html","C27H41F2N5O","free base","PF-3084014","CCCC(NC1CCC2=CC(=CC(=C2C1)F)F)C(=O)NC3=C[N](C=N3)C(C)(C)CNCC(C)(C)C",5.042,2,3,11]
["S8019","Capivasertib (AZD5363)","b4","L3900-28","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.",428.92,"1143532-39-1",{"v":86,"d":"86.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://selleckchem.com/products/azd5363.html","C21H25ClN6O2","free base","N/A","NC1(CCN(CC1)C2=NC=NC3=C2C=C[NH]3)C(=O)NC(CCO)C4=CC=C(Cl)C=C4",1.317,3,4,6]
["S8020","GW0742","c4","L3900-28","in 10mM DMSO","PPAR","Metabolism","GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.",471.49,"317318-84-6",{"v":94,"d":"94.00"},199.37,"<1","N/A","http://selleckchem.com/products/gw0742.html","C21H17F4NO3S2","free base","N/A","CC1=CC(=CC=C1OCC(O)=O)SCC2=C(C)N=C(S2)C3=CC=C(C(=C3)F)C(F)(F)F",5.795,3,0,8]
["S8022","Empagliflozin (BI 10773)","d4","L3900-28","in 10mM DMSO","SGLT","GPCR & G Protein","Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.",450.91,"864070-44-0",{"v":90,"d":"90.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/empagliflozin-bi10773.html","C23H27ClO7","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=CC(=C(Cl)C=C2)CC3=CC=C(OC4CCOC4)C=C3",1.839,3,4,6]
["S8024","Tyrphostin AG 1296","e4","L3900-28","in 10mM DMSO","Apoptosis related,c-Kit,FGFR,PDGFR","Protein Tyrosine Kinase","Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.",266.29,"146535-11-7",{"v":6,"d":"6.00"},22.53,"<1","N/A","http://selleckchem.com/products/tyrphostin-ag-1296-ag-1296.html","C16H14N2O2","free base","AG 1296","COC1=CC2=NC=C(N=C2C=C1OC)C3=CC=CC=C3",3.208,4,0,3]
["S8025","GSK3787","f4","L3900-28","in 10mM DMSO","PPAR","Metabolism","GSK3787 is a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ.",392.78,"188591-46-0",{"v":79,"d":"79.00"},201.13,"<1","N/A","http://selleckchem.com/products/gsk3787.html","C15H12ClF3N2O3S","free base","N/A","FC(F)(F)C1=CC=C(N=C1)[S](=O)(=O)CCNC(=O)C2=CC=C(Cl)C=C2",3.207,4,1,6]
["S8028","Tariquidar (XR9576)","g4","L3900-28","in 10mM DMSO","P-gp","Transmembrane Transporters","Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM in CHrB30 cell line, reverses drug resistance in MDR cell Lines. Phase 3.",646.73,"206873-63-4",{"v":52,"d":"52.00"},{"v":80.4,"d":"80.40"},"<1","N/A","http://selleckchem.com/products/tariquidar.html","C38H38N4O6","free base","XR9576","COC1=CC2=C(CN(CCC3=CC=C(NC(=O)C4=C(NC(=O)C5=CC6=CC=CC=C6N=C5)C=C(OC)C(=C4)OC)C=C3)CC2)C=C1OC",5.573,7,2,11]
["S8032","PRT062607 (P505-15) HCl","h4","L3900-28","in 10mM DMSO","FAK,FLT3,Mixed Lineage Kinase,PAK,Pyk2,Src,Syk","Angiogenesis","PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.",429.91,"1370261-97-4",{"v":86,"d":"86.00"},200.04,{"v":86,"d":"86.00"},200.04,"http://selleckchem.com/products/prt062607-p505-15-hcl.html","C19H23N9O.HCl","Hydrochloride","BIIB057, PRT-2607","Cl.NC1CCCCC1NC2=NC=C(C(N)=O)C(=N2)NC3=CC(=CC=C3)[N]4N=CC=N4",2.033,5,4,6]
["S8034","Apremilast (CC-10004)","a5","L3900-28","in 10mM DMSO","PDE,TNF-alpha","Metabolism","Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.",{"v":460.5,"d":"460.50"},"608141-41-9",{"v":92,"d":"92.00"},199.78,"<1","N/A","http://selleckchem.com/products/apremilast-cc-10004.html","C22H24N2O7S","free base","CC-10004","CCOC1=C(OC)C=CC(=C1)C(C[S](C)(=O)=O)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(C)=O",1.509,7,1,8]
["S8039","Zelavespib (PU-H71)","b5","L3900-28","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Zelavespib (PU-H71, NSC 750424) is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.",512.37,"873436-91-0",{"v":100,"d":"100.00"},195.17,{"v":34,"d":"34.00"},66.36,"http://selleckchem.com/products/pu-h71.html","C18H21IN6O2S","free base","NSC 750424","CC(C)NCCC[N]1C(=NC2=C(N)N=CN=C12)SC3=CC4=C(OCO4)C=C3I",3.162,5,2,7]
["S8040","GDC-0349","c5","L3900-28","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.",452.55,"1207360-89-1",{"v":91,"d":"91.00"},201.08,"<1","N/A","http://selleckchem.com/products/gdc-0349.html","C24H32N6O3","free base","RG-7603","CCNC(=O)NC1=CC=C(C=C1)C2=NC(=C3CCN(CC3=N2)C4COC4)N5CCOCC5C",1.982,5,2,5]
["S8041","Cobimetinib (GDC-0973)","d5","L3900-28","in 10mM DMSO","Apoptosis related,MEK","MAPK","Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.",531.31,"934660-93-2",{"v":100,"d":"100.00"},188.21,"<1","N/A","http://selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html","C21H21F3IN3O2","free base","RG7420,XL518","OC1(CN(C1)C(=O)C2=C(NC3=CC=C(I)C=C3F)C(=C(F)C=C2)F)C4CCCCN4",3.701,1,2,4]
["S8048","Venetoclax (ABT-199)","e5","L3900-28","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.",868.44,"1257044-40-8",{"v":100,"d":"100.00"},115.15,"<1","N/A","http://selleckchem.com/products/abt-199.html","C45H50ClN7O7S","free base","GDC-0199","CC1(C)CCC(=C(C1)C2=CC=C(Cl)C=C2)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)N[S](=O)(=O)C5=CC=C(NCC6CCOCC6)C(=C5)[N+]([O-])=O)OC7=CN=C8[NH]C=CC8=C7",{"v":7.94,"d":"7.940"},6,3,13]
["S8051","Macitentan (ACT 064992)","f5","L3900-28","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Macitentan (ACT 064992) is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.",588.27,"441798-33-0",{"v":100,"d":"100.00"},169.99,"<1","N/A","http://selleckchem.com/products/macitentan.html","C19H20Br2N6O4S","free base","ACT 064992","CCCN[S](=O)(=O)NC1=NC=NC(=C1C2=CC=C(Br)C=C2)OCCOC3=NC=C(Br)C=N3",3.671,8,2,11]
["S8054","ASP3026","g5","L3900-28","in 10mM DMSO","ALK","Protein Tyrosine Kinase","ASP3026 is a novel and selective inhibitor for ALK  with IC50 of 3.5 nM. Phase 1.",580.74,"1097917-15-1",{"v":14,"d":"14.00"},24.11,"<1","N/A","http://selleckchem.com/products/asp3026.html","C29H40N8O3S","free base","N/A","COC1=CC(=CC=C1NC2=NC(=NC=N2)NC3=CC=CC=C3[S](=O)(=O)C(C)C)N4CCC(CC4)N5CCN(C)CC5",4.554,6,2,9]
["S8056","Lomeguatrib","h5","L3900-28","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.",326.17,"192441-08-0",{"v":65,"d":"65.00"},199.28,"<1","N/A","http://selleckchem.com/products/lomeguatrib.html","C10H8BrN5OS","free base","PaTrin-2","NC1=NC2=C([NH]C=N2)C(=N1)OCC3=CC(=CS3)Br",2.131,4,2,3]
["S8057","Pacritinib (SB1518)","a6","L3900-28","in 10mM DMSO","FLT3,JAK","JAK/STAT","Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.",472.58,"937272-79-2",{"v":11,"d":"11.00"},23.28,"<1","N/A","http://selleckchem.com/products/pacritinib-sb1518.html","C28H32N4O3","free base","N/A","C1CCN(C1)CCOC2=CC=C3NC4=NC=CC(=N4)C5=CC(=CC=C5)COC\\C=C\\COCC2=C3",4.547,5,1,4]
["S8058","Riviciclib hydrochloride (P276-00)","b6","L3900-28","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Riviciclib hydrochloride (P276-00) induces apoptosis. Phase 2/3.",{"v":438.3,"d":"438.30"},"920113-03-7",{"v":88,"d":"88.00"},200.78,{"v":88,"d":"88.00"},200.78,"http://selleckchem.com/products/p276-00.html","C21H20ClNO5.HCl","hydrochloride","N/A","Cl.CN1CCC(C1CO)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,3]
["S8061","Sabutoclax","c6","L3900-28","in 10mM DMSO","Bcl-2","Apoptosis","Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50  of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.",700.78,"1228108-65-3",{"v":100,"d":"100.00"},{"v":142.7,"d":"142.70"},"<1","N/A","http://selleckchem.com/products/sabutoclax.html","C42H40N2O8","free base","BI-97C1","CC(CNC(=O)C1=C(O)C(=CC2=C1C=C(C)C(=C2O)C3=C(O)C4=CC(=C(O)C(=C4C=C3C)C(=O)NCC(C)C5=CC=CC=C5)O)O)C6=CC=CC=C6",7.549,2,8,9]
["S8067","Vorapaxar (MK-5348)","d6","L3900-28","in 10mM DMSO","PAR","GPCR & G Protein","Vorapaxar (SCH 530348, MK-5348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.",492.58,"618385-01-6",{"v":99,"d":"99.00"},200.98,"<1","N/A","http://selleckchem.com/products/vorapaxar.html","C29H33FN2O4","free base","SCH 530348","CCOC(=O)NC1CCC2C(C1)CC3C(C(C)OC3=O)C2\\C=C\\C4=CC=C(C=N4)C5=CC=CC(=C5)F",5.261,5,1,6]
["S8078","Bardoxolone Methyl","e6","L3900-28","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8097","C-DIM12","f6","L3900-28","in 10mM DMSO","Dopamine Receptor,Immunology & Inflammation related","Neuronal Signaling","C-DIM12 is a Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.",356.85,"178946-89-9",{"v":71,"d":"71.00"},198.96,"<1","N/A","http://selleckchem.com/products/c-dim12.html","C23H17ClN2","free base","N/A","ClC1=CC=C(C=C1)C(C2=C[NH]C3=C2C=CC=C3)C4=C[NH]C5=C4C=CC=C5",6.339,0,2,3]
["S8101","CB-5083","g6","L3900-28","in 10mM DMSO","ATPase,p97","Transmembrane Transporters","CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.",413.47,"1542705-92-9",{"v":82,"d":"82.00"},198.32,"<1","N/A","http://selleckchem.com/products/cb-5083.html","C24H23N5O2","free base","N/A","CC1=CC2=C(C=CC=C2C(N)=O)[N]1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5",3.748,4,2,5]
["S8103","Sotagliflozin (LX4211)","h6","L3900-28","in 10mM DMSO","SGLT","GPCR & G Protein","Sotagliflozin (LX4211, LP-802034) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.",424.94,"1018899-04-1",{"v":84,"d":"84.00"},197.67,"<1","N/A","http://selleckchem.com/products/sotagliflozin-lx4211.html","C21H25ClO5S","free base","LP-802034","CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)C3OC(SC)C(O)C(O)C3O)C=C1",3.734,2,3,6]
["S8104","SCH58261","a7","L3900-28","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.",345.36,"160098-96-4",{"v":69,"d":"69.00"},199.79,"<1","N/A","http://selleckchem.com/products/sch58261.html","C18H15N7O","free base","N/A","NC1=NC2=C(C=N[N]2CCC3=CC=CC=C3)C4=NC(=N[N]14)C5=CC=CO5",{"v":2.74,"d":"2.740"},5,1,4]
["S8105","ZM241385","b7","L3900-28","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.",337.34,"139180-30-6",{"v":67,"d":"67.00"},198.61,"<1","N/A","http://selleckchem.com/products/zm241385.html","C16H15N7O2","free base","N/A","NC1=NC(=NC2=NC(=N[N]12)C3=CC=CO3)NCCC4=CC=C(O)C=C4",2.917,5,3,5]
["S8116","Acalabrutinib (ACP-196)","c7","L3900-28","in 10mM DMSO","BTK","Angiogenesis","Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.",465.51,"1420477-60-6",{"v":93,"d":"93.00"},199.78,"<1","N/A","http://selleckchem.com/products/acalabrutinib.html","C26H23N7O2","free base","N/A","CC#CC(=O)N1CCCC1C2=NC(=C3[N]2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC=C5",2.699,5,2,5]
["S8117","GMX1778 (CHS828)","d7","L3900-28","in 10mM DMSO","Apoptosis related,NAMPT","Metabolism","GMX1778 (CHS828) is a potent and specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with IC50 and Kd of < 25 nM and 120 nM, respectively. GMX1778 induces programmed cell death with apoptotic features. Phase 1.",371.86,"200484-11-3",{"v":74,"d":"74.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/gmx1778-chs828.html","C19H22ClN5O","free base","N/A","ClC1=CC=C(OCCCCCCNC(NC2=CC=NC=C2)=NC#N)C=C1",{"v":3.84,"d":"3.840"},3,2,11]
["S8118","RHPS 4 methosulfate","e7","L3900-28","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.",458.48,"390362-78-4",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/rhps4-nsc714187.html","C22H17F2N2.CH3O4S","methyl sulfate","NSC714187","CO[S]([O-])(=O)=O.CN1C2=CC=C(F)C=C2C3=[N+](C)C4=C(C=C(F)C=C4)C5=CC(=CC1=C35)C",3.363,1,0,1]
["S8124","BMS-582949","f7","L3900-28","in 10mM DMSO","p38 MAPK","MAPK","BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.",406.48,"623152-17-0",{"v":81,"d":"81.00"},199.27,"<1","N/A","http://selleckchem.com/products/bms-582949.html","C22H26N6O2","free base","PS540446","CCCNC(=O)C1=C[N]2N=CN=C(NC3=CC(=CC=C3C)C(=O)NC4CC4)C2=C1C",3.269,4,3,7]
["S8125","Pamapimod","g7","L3900-28","in 10mM DMSO","p38 MAPK","MAPK","Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.",406.38,"449811-01-2",{"v":81,"d":"81.00"},199.32,"<1","N/A","http://selleckchem.com/products/pamapimod-r-1503-ro4402257.html","C19H20F2N4O4","free base","R-1503,Ro4402257","CN1C(=O)C(=CC2=CN=C(NC(CCO)CCO)N=C12)OC3=C(F)C=C(F)C=C3",1.298,4,3,8]
["S8126","MK571","h7","L3900-28","in 10mM DMSO","LTR","Immunology & Inflammation","MK571 (L660711) is a selective, orally active CysLT1 receptor(Cysteinyl leukotriene receptor) antagonist.",515.09,"115104-28-4",{"v":100,"d":"100.00"},194.14,"<1","N/A","http://selleckchem.com/products/mk571.html","C26H27ClN2O3S2","free base","L-660711, L660711, MK-571, MK 571","[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)C1=CC(=CC=C1)/C=C/C2=NC3=CC(=CC=C3C=C2)Cl",4.227,2,0,11]
["S8128","BAY 41-2272","a8","L3900-28","in 10mM DMSO","Guanylate Cyclase","GPCR & G Protein","BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.",360.39,"256376-24-6",{"v":35,"d":"35.00"},97.12,"<1","N/A","http://selleckchem.com/products/bay-41-2272.html","C20H17FN6","free base","N/A","NC1=NC(=NC=C1C2CC2)C3=N[N](CC4=C(F)C=CC=C4)C5=NC=CC=C35",3.402,4,1,4]
["S8133","Resiquimod (R-848)","b8","L3900-28","in 10mM DMSO","HCV,IFN,Interleukins,TLR,TNF-alpha","Immunology & Inflammation","Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2.",314.38,"144875-48-9",{"v":63,"d":"63.00"},200.39,"<1","N/A","http://selleckchem.com/products/resiquimod.html","C17H22N4O2","free base","S28463","CCOCC1=NC2=C([N]1CC(C)(C)O)C3=C(C=CC=C3)N=C2N",1.919,3,1,5]
["S8134","Radotinib","c8","L3900-28","in 10mM DMSO","Bcr-Abl","Angiogenesis","Radotinib (IY-5511) is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia.",{"v":530.5,"d":"530.50"},"926037-48-1",{"v":100,"d":"100.00"},{"v":188.5,"d":"188.50"},"<1","N/A","http://selleckchem.com/products/radotinib.html","C27H21F3N8O","free base","IY-5511","CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=NC=CN=C5",4.362,6,2,7]
["S8135","Riociguat (BAY 63-2521)","d8","L3900-28","in 10mM DMSO","Guanylate Cyclase","GPCR & G Protein","Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.",422.42,"625115-55-1",{"v":84,"d":"84.00"},198.85,"<1","N/A","http://selleckchem.com/products/riociguat-bay-63-2521.html","C20H19FN8O2","free base","N/A","COC(=O)N(C)C1=C(N)N=C(N=C1N)C2=N[N](CC3=CC=CC=C3F)C4=NC=CC=C24",2.341,6,2,5]
["S8136","Sivelestat (ONO-5046)","e8","L3900-28","in 10mM DMSO","Serine Protease","Proteases","Sivelestat (ONO5046, LY544349, EI546) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.",434.46,"127373-66-4",{"v":86,"d":"86.00"},197.95,"<1","N/A","http://selleckchem.com/products/sivelestat-ono-5046.html","C20H22N2O7S","Free Base","ONO5046, LY544349, EI546","CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC(O)=O",2.321,6,2,9]
["S8144","Halofuginone","f8","L3900-28","in 10mM DMSO","DNA/RNA Synthesis,TGF-beta/Smad","DNA Damage/DNA Repair","Halofuginone (RU-19110) is the competitively inhibitor of  prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.",414.68,"55837-20-2",{"v":20,"d":"20.00"},48.23,"<1","N/A","http://selleckchem.com/products/halofuginone.html","C16H17BrClN3O3","free base","RU-19110","OC1CCCNC1CC(=O)CN2C=NC3=CC(=C(Cl)C=C3C2=O)Br",1.648,3,2,4]
["S8161","ON123300","g8","L3900-28","in 10mM DMSO","AMPK,CDK,c-RET,FGFR,PDGFR,Src","Cell Cycle","ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn, respectively.",429.52,"1357470-29-1",{"v":29,"d":"29.00"},67.52,"<1","N/A","http://selleckchem.com/products/on123300.html","C24H27N7O","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C4C=C(C#N)C(=O)N(C5CCCC5)C4=N3)C=C2",{"v":3.65,"d":"3.650"},3,1,4]
["S8163","Paxalisib (GDC-0084)","h8","L3900-28","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.",382.42,"1382979-44-3",{"v":8,"d":"8.00"},20.92,"<1","N/A","http://selleckchem.com/products/gdc-0084.html","C18H22N8O2","free base","RG7666","CC1(C)OCC[N]2C3=C(N=C12)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",0.588,7,1,2]
["S8166","tirabrutinib(ONO-4059) hydrochloride","a9","L3900-28","in 10mM DMSO","BTK","Angiogenesis","Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with an IC50 of 2.2 nM.",490.94,"1439901-97-9",{"v":98,"d":"98.00"},199.62,"<1","N/A","http://selleckchem.com/products/ono-4059-gs-4059.html","C25H22N6O3.HCl","hydrochloride","GS-4059","Cl.CC#CC(=O)N1CCC(C1)N2C(=O)N(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C25",3.706,5,1,5]
["S8167","AMG 337","b9","L3900-28","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM.",463.46,"1173699-31-4",{"v":95,"d":"95.00"},204.98,"<1","N/A","http://selleckchem.com/products/amg-337.html","C23H22FN7O3","free base","N/A","COCCOC1=CC2=C(C=CN(C(C)C3=NN=C4[N]3C=C(C=C4F)C5=C[N](C)N=C5)C2=O)N=C1",1.188,7,0,7]
["S8171","Daprodustat (GSK1278863)","c9","L3900-28","in 10mM DMSO","HIF","Angiogenesis","Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.",393.43,"960539-70-2",{"v":10,"d":"10.00"},25.42,"<1","N/A","http://selleckchem.com/products/daprodustat.html","C19H27N3O6","free base","N/A","OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C3CCCCC3)C1=O",1.747,5,1,5]
["S8172","Ro 61-8048","d9","L3900-28","in 10mM DMSO","Hydroxylase","Metabolism","Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.",421.45,"199666-03-0",{"v":84,"d":"84.00"},199.31,"<1","N/A","http://selleckchem.com/products/ro-61-8048.html","C17H15N3O6S2","free base","N/A","COC1=C(OC)C=C(C=C1)[S](=O)(=O)NC2=NC(=CS2)C3=CC=CC(=C3)[N+]([O-])=O",3.123,5,1,7]
["S8173","Verubecestat (MK-8931) Trifluoroacetate","e9","L3900-28","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.",523.43,"2095432-65-6",{"v":81,"d":"81.00"},154.75,"<1","N/A","http://selleckchem.com/products/verubecestat-mk-8931.html","C19H18F5N5O5S","Trifluoroacetat","MK-8931","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3.OC(=O)C(F)(F)F",2.198,5,2,4]
["S8183","Pimavanserin tartrate","f9","L3900-28","in 10mM DMSO","5-HT Receptor","GPCR & G Protein","Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.",{"v":1005.2,"d":"1005.20"},"706782-28-7",{"v":100,"d":"100.00"},99.48,{"v":100,"d":"100.00"},99.48,"http://selleckchem.com/products/pimavanserin.html","C50H68F2N6O4.C4H6O6","tartrate","ACP-103","CC(C)COC1=CC=C(CNC(=O)N(CC2=CC=C(F)C=C2)C3CCN(C)CC3)C=C1.CC(C)COC4=CC=C(CNC(=O)N(CC5=CC=C(F)C=C5)C6CCN(C)CC6)C=C4.OC(C(O)C(O)=O)C(O)=O",0.735,6,4,19]
["S8188","BFH772","g9","L3900-28","in 10mM DMSO","VEGFR","Angiogenesis","BFH772 is a novel potent oral VEGFR2 inhibitor, targeting VEGFR2 kinase with IC50 of 3 nM.",439.39,"890128-81-1",{"v":87,"d":"87.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/bfh772.html","C23H16F3N3O3","free base","BFH 772, BFH-772","OCC1=CC(=NC=N1)OC2=CC=C3C(=C2)C=CC=C3C(=O)NC4=CC(=CC=C4)C(F)(F)F",4.396,4,2,6]
["S8193","Lanabecestat (AZD3293)","h9","L3900-28","in 10mM DMSO","BACE","Neuronal Signaling","Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki  of 0.4 nM.",412.53,"1383982-64-6",{"v":82,"d":"82.00"},198.77,"<1","N/A","http://selleckchem.com/products/azd3293-ly3314814.html","C26H28N4O","free base","LY3314814","COC1CCC2(CC1)CC3=C(C=C(C=C3)C4=CN=CC(=C4)C#CC)C25N=C(C)C(=N5)N",3.882,4,1,3]
["S8194","umbralisib (TGR-1202)","a10","L3900-28","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Umbralisib (TGR-1202, Rp-5264), a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively.",571.55,"1532533-67-7",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/tgr-1202.html","C31H24F3N5O3","free base","Rp-5264","CC(C)OC1=C(F)C=C(C=C1)C2=N[N](C(C)C3=C(C4=CC(=CC=C4)F)C(=O)C5=CC(=CC=C5O3)F)C6=C2C(=NC=N6)N",6.393,6,1,6]
["S8200","MK-4101","b10","L3900-28","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.",493.47,"935273-79-3",{"v":98,"d":"98.00"},198.59,"<1","N/A","http://selleckchem.com/products/mk-4101.html","C24H24F5N5O","free base","N/A","C[N]1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(F)(F)C5)C6=CC=CC=C6C(F)(F)F",4.784,5,0,5]
["S8205","Enasidenib (AG-221)","c10","L3900-28","in 10mM DMSO","Dehydrogenase","Metabolism","Enasidenib (AG-221) is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme.",473.38,"1446502-11-9",{"v":94,"d":"94.00"},198.57,"<1","N/A","http://selleckchem.com/products/ag-221-enasidenib.html","C19H17F6N7O","free base","N/A","CC(C)(O)CNC1=NC(=NC(=N1)NC2=CC=NC(=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F",4.878,5,2,8]
["S8206","Ivosidenib (AG-120)","d10","L3900-28","in 10mM DMSO","Dehydrogenase","Metabolism","Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.",582.96,"1448347-49-6",{"v":100,"d":"100.00"},171.54,"<1","N/A","http://selleckchem.com/products/ag-120-Ivosidenib.html","C28H22ClF3N6O3","free base","N/A","FC1=CN=CC(=C1)N(C(C(=O)NC2CC(F)(F)C2)C3=C(Cl)C=CC=C3)C(=O)C4CCC(=O)N4C5=NC=CC(=C5)C#N",3.004,5,1,7]
["S8215","BAY 1217389","e10","L3900-28","in 10mM DMSO","MPS1","Cell Cycle","BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.",{"v":561.5,"d":"561.50"},"1554458-53-5",{"v":100,"d":"100.00"},178.09,"<1","N/A","http://selleckchem.com/products/bay-1217389.html","C27H24F5N5O3","free base","N/A","COC1=CC=C(OC2=N[N]3C(=CN=C3C(=C2)NCCC(F)(F)F)C4=CC(=C(C=C4)C(=O)NC5CC5)C)C(=C1F)F",5.255,5,2,10]
["S8219","Bitopertin","f10","L3900-28","in 10mM DMSO","Amino acid transporter,GlyT","Neuronal Signaling","Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.",543.46,"845614-11-1",{"v":100,"d":"100.00"},184.01,"<1","N/A","http://selleckchem.com/products/bitopertin-rg1678-ro-4917838.html","C21H20F7N3O4S","free base","RG1678, RO-4917838","CC(OC1=CC=C(C=C1C(=O)N2CCN(CC2)C3=NC=C(C=C3F)C(F)(F)F)[S](C)(=O)=O)C(F)(F)F",4.304,5,0,7]
["S8228","NT157","g10","L3900-28","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.",412.26,"1384426-12-3",{"v":82,"d":"82.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/nt157.html","C16H14BrNO5S","free base","N/A","OC1=CC(=CC(=C1O)O)CNC(=S)/C=C/C2=CC(=C(O)C(=C2)Br)O",3.721,0,6,5]
["S8234","RS-1","h10","L3900-28","in 10mM DMSO","CRISPR/Cas9,RAD51","DNA Damage/DNA Repair","RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.",524.23,"312756-74-4",{"v":100,"d":"100.00"},190.76,"<1","N/A","http://selleckchem.com/products/rs-1.html","C20H16Br2N2O3S","free base","N/A","BrC1=CC=C(NC(=O)C2=CC=C(Br)C(=C2)[S](=O)(=O)NCC3=CC=CC=C3)C=C1",4.606,3,2,6]
["S8236","MK-886","a11","L3900-28","in 10mM DMSO","FLAP","Immunology & Inflammation","MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.",472.08,"118414-82-7",{"v":94,"d":"94.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-886-l-663-536.html","C27H34ClNO2S","free base","L-663,536","CC(C)C1=CC=C2[N](CC3=CC=C(Cl)C=C3)C(=C(SC(C)(C)C)C2=C1)CC(C)(C)C(O)=O",8.114,1,0,8]
["S8241","Ponesimod","b11","L3900-28","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Ponesimod (ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.",460.97,"854107-55-4",{"v":92,"d":"92.00"},199.58,"<1","N/A","http://selleckchem.com/products/ponesimod-act-128800.html","C23H25ClN2O4S","free base","ACT-128800","CCCN=C1S\\C(=C/C2=CC=C(OCC(O)CO)C(=C2)Cl)C(=O)N1C3=CC=CC=C3C",4.941,3,2,8]
["S8244","Etomoxir sodium salt","c11","L3900-28","in 10mM DMSO","Apoptosis related,CPT,Transferase","Metabolism","Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.",320.74,"828934-41-4",{"v":64,"d":"64.00"},199.54,{"v":64,"d":"64.00"},199.54,"http://selleckchem.com/products/etomoxir-na-salt.html","C15H18ClO4.Na","sodium salt","(R)-(+)-Etomoxir sodium salt","[Na]OC(=O)C1(CCCCCCOC2=CC=C(Cl)C=C2)CO1",3.847,4,0,10]
["S8253","CCT245737","d11","L3900-28","in 10mM DMSO","Chk","Cell Cycle","CCT245737 (SRA737, PNT-737) is an orally active CHK1 inhibitor with The IC50 of 1.4 nM. It exhibits >1,000-fold selectivity against CHK2 and CDK1.",379.34,"1489389-18-5",{"v":75,"d":"75.00"},197.71,"<1","N/A","http://selleckchem.com/products/cct245737.html","C16H16F3N7O","free base","SRA737, PNT-737","FC(F)(F)C1=CN=C(NC2=CN=C(C=N2)C#N)C=C1NCC3CNCCO3",{"v":1.46,"d":"1.460"},4,3,6]
["S8270","SRT2183","e11","L3900-28","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.",468.57,"1001908-89-9",{"v":93,"d":"93.00"},198.48,"<1","N/A","http://selleckchem.com/products/srt2183.html","C27H24N4O2S","free base","N/A","OC1CCN(C1)CC2=CSC3=NC(=C[N]23)C4=C(NC(=O)C5=CC6=C(C=CC=C6)C=C5)C=CC=C4",{"v":3.6,"d":"3.600"},2,2,5]
["S8275","Tomivosertib (eFT-508)","f11","L3900-28","in 10mM DMSO","eIF,MNK,PD-1/PD-L1","MAPK","Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.",340.38,"1849590-01-7",{"v":13,"d":"13.00"},38.19,"<1","N/A","http://selleckchem.com/products/eft-508.html","C17H20N6O2","free base","N/A","CC1=C2N(C(=O)C(=C1)NC3=NC=NC(=C3)N)C4(CCCCC4)NC2=O",0.717,4,3,2]
["S8278","SHP099 HCl","g11","L3900-28","in 10mM DMSO","phosphatase","Metabolism","SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.",388.72,"2200214-93-1",{"v":77,"d":"77.00"},{"v":181.1,"d":"181.10"},{"v":2,"d":"2.00"},{"v":4.7,"d":"4.70"},"http://selleckchem.com/products/shp099-dihydrochloride.html","C16H20Cl3N5","Dihydrochloride","N/A","Cl.CC1(N)CCN(CC1)C2=CN=C(C(=N2)N)C3=CC=CC(=C3Cl)Cl",{"v":3.41,"d":"3.410"},2,2,2]
["S8286","MKC-3946","h11","L3900-28","in 10mM DMSO","IRE1","ER stress & UPR","MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.",380.46,"1093119-54-0",{"v":38,"d":"38.00"},99.88,"<1","N/A","http://selleckchem.com/products/mkc-3946.html","C21H20N2O3S","free base","N/A","CN1CCN(CC1)C(=O)C2=CC=C(S2)C3=CC4=CC=C(O)C(=C4C=C3)C=O",{"v":3.39,"d":"3.390"},2,1,3]
["S8288","VLX1570","a2","L3900-29","in 10mM DMSO","DUB","Ubiquitin","VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.",469.39,"1431280-51-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://selleckchem.com/products/vlx1570.html","C23H17F2N3O6","free base","N/A","[O-][N+](=O)C1=C(F)C=CC(=C1)\\C=C2/CCN(C\\C(=C/C3=CC=C(F)C(=C3)[N+]([O-])=O)C2=O)C(=O)C=C",4.385,2,0,5]
["S8292","Selonsertib (GS-4997)","b2","L3900-29","in 10mM DMSO","ASK","Apoptosis","Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.",445.49,"1448428-04-3",{"v":36,"d":"36.00"},80.81,"<1","N/A","http://selleckchem.com/products/selonsertib-gs-4997.html","C24H24FN7O","free base","N/A","CC(C)[N]1C=NN=C1C2=CC=CC(=N2)NC(=O)C3=CC(=C(C)C=C3F)[N]4C=NC(=C4)C5CC5",4.054,5,1,6]
["S8294","Olmutinib (BI 1482694)","c2","L3900-29","in 10mM DMSO","BTK,EGFR","Protein Tyrosine Kinase","Olmutinib (BI 1482694) is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of Bruton's tyrosine kinase.",486.59,"1353550-13-6",{"v":97,"d":"97.00"},199.35,"<1","N/A","http://selleckchem.com/products/olmutinib-hm61713-bi-1482694.html","C26H26N6O2S","free base","HM61713","CN1CCN(CC1)C2=CC=C(NC3=NC(=C4SC=CC4=N3)OC5=CC=CC(=C5)NC(=O)C=C)C=C2",5.449,4,2,7]
["S8301","Ossirene","d2","L3900-29","in 10mM DMSO","Immunology & Inflammation related,Interleukins","Immunology & Inflammation","AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.",312.05,"106566-58-9",{"v":62,"d":"62.00"},198.69,"<1","N/A","http://selleckchem.com/products/as101.html","C2H4Cl3O2Te.H4N","Coordination Co","AS101","[NH4+].Cl[Te-]1(Cl)(Cl)OCCO1",-0.379,2,0,0]
["S8302","SR-12813","e2","L3900-29","in 10mM DMSO","HMG-CoA Reductase","Metabolism","SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.",504.53,"126411-39-0",{"v":100,"d":"100.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/sr-12813.html","C24H42O7P2","free base","N/A","CCO[P](=O)(OCC)C(=CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)[P](=O)(OCC)OCC",4.891,4,1,13]
["S8309","ATI-2341","f2","L3900-29","in 10mM DMSO","CXCR","GPCR & G Protein","ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.",2256.82,"1337878-62-2",{"v":100,"d":"100.00"},44.31,"<1","N/A","http://selleckchem.com/products/ati-2341.html","C104H178N26O25S2","free base","N/A","CCCCCCCCCCCCCCCC(=O)NC(CCSC)C(=O)NCC(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CCSC)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=C(O)C=C2)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O",-5.119,19,28,89]
["S8321","MLR-1023","g2","L3900-29","in 10mM DMSO","Src","Protein Tyrosine Kinase","MLR-1023 (Tolimidone, CP-26154) is a Lyn kinase activator and a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.",202.21,"41964-07-2",{"v":40,"d":"40.00"},197.81,"<1","N/A","http://selleckchem.com/products/mlr-1023.html","C11H10N2O2","free base","Tolimidone, CP-26154","CC1=CC=CC(=C1)OC2=CNC(=O)N=C2",1.443,3,1,2]
["S8322","Samotolisib (LY3023414)","h2","L3900-29","in 10mM DMSO","DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.",406.48,"1386874-06-1",{"v":47,"d":"47.00"},115.63,"<1","N/A","http://selleckchem.com/products/ly3023414.html","C23H26N4O3","free base","GTPL8918","COC(C)CN1C(=O)N(C)C2=C1C3=CC(=CC=C3N=C2)C4=CC(=CN=C4)C(C)(C)O",1.883,4,0,5]
["S8330","Eganelisib (IPI-549)","a3","L3900-29","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Eganelisib (IPI-549) is a potent inhibitor of PI3K-γ with >100-fold selectivity over other lipid and protein kinases. The biochemical IC50 for PI3K-γ is 16 nM.",528.56,"1693758-51-8",{"v":100,"d":"100.00"},189.19,"<1","N/A","http://selleckchem.com/products/ipi-549.html","C30H24N8O2","free base","N/A","CC(NC(=O)C1=C2N=CC=C[N]2N=C1N)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)C#CC6=C[N](C)N=C6",2.732,5,2,6]
["S8335","PF-06409577","b3","L3900-29","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.",341.79,"1467057-23-3",{"v":68,"d":"68.00"},198.95,"<1","N/A","http://selleckchem.com/products/pf-06409577.html","C19H16ClNO3","free base","N/A","OC(=O)C1=C[NH]C2=CC(=C(C=C12)C3=CC=C(C=C3)C4(O)CCC4)Cl",4.133,1,1,3]
["S8339","Miransertib (ARQ 092) HCl","c3","L3900-29","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.",468.98,"1313883-00-9",{"v":75,"d":"75.00"},159.92,"<1","N/A","http://selleckchem.com/products/arq-092.html","C27H25ClN6","hydrochloride","Miransertib","Cl.NC1=NC=CC=C1C2=NC3=CC=C(N=C3[N]2C4=CC=C(C=C4)C5(N)CCC5)C6=CC=CC=C6",{"v":4.98,"d":"4.980"},3,2,4]
["S8352","PT2385","d3","L3900-29","in 10mM DMSO","HIF","Epigenetics","PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.",383.34,"1672665-49-4",{"v":77,"d":"77.00"},200.87,"<1","N/A","http://www.selleckchem.com/products/pt2385.html","C17H12F3NO4S","Free Base","N/A","C[S](=O)(=O)C1=CC=C(OC2=CC(=CC(=C2)F)C#N)C3=C1C(O)C(F)(F)C3",2.732,3,1,3]
["S8353","Lirametostat (CPI-1205)","e3","L3900-29","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.",518.57,"1621862-70-1",{"v":100,"d":"100.00"},192.84,"<1","N/A","http://selleckchem.com/products/cpi-1205.html","C27H33F3N4O3","free base","CPI 1205, CPI1205","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCN(CC3)CC(F)(F)F)C4=C2C=CC=C4)C(=O)NC(=C1)C",3.348,3,2,8]
["S8362","Tucatinib","f3","L3900-29","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Tucatinib (Irbinitinib, ONT-380, ARRY-380) is an oral, potent, selective, reversible and ATP-competitive small-molecule inhibitor of ErbB-2 (also called HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively in cell-based assays, showing ~500-fold selective for HER2 vs EGFR. It has potential antineoplastic activity.",480.52,"937263-43-9",{"v":96,"d":"96.00"},199.78,"<1","N/A","http://selleckchem.com/products/arry-380-ont-380.html","C26H24N8O2","free base","Irbinitinib, ONT-380, ARRY-380","CC1=CC(=CC=C1OC2=CC3=NC=N[N]3C=C2)NC4=NC=NC5=CC=C(NC6=NC(C)(C)CO6)C=C45",4.744,7,2,6]
["S8363","NMS-P118","g3","L3900-29","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).",395.42,"1262417-51-5",{"v":24,"d":"24.00"},60.69,"<1","N/A","http://selleckchem.com/products/nms-p118.html","C20H24F3N3O2","free base","N/A","NC(=O)C1=CC(=CC2=C1C(=O)N(C2)C3CCN(CC3)C4CCC(F)(F)CC4)F",1.422,2,1,3]
["S8370","BGP-15 2HCl","h3","L3900-29","in 10mM DMSO","PARP","DNA Damage/DNA Repair","BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.",351.27,"66611-37-8",{"v":70,"d":"70.00"},199.28,{"v":70,"d":"70.00"},199.28,"http://selleckchem.com/products/bgp-15.html","C14H22N4O2.2HCl","dihydrochloride","N/A","Cl.Cl.NC(=N\\OCC(O)CN1CCCCC1)/C2=CC=CN=C2",1.097,3,2,6]
["S8372","AZD9496","a4","L3900-29","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.",442.47,"1639042-08-2",{"v":88,"d":"88.00"},198.88,"<1","N/A","http://selleckchem.com/products/azd9496.html","C25H25F3N2O2","free base","N/A","CC1CC2=C([NH]C3=CC=CC=C23)C(N1CC(C)(C)F)C4=C(F)C=C(\\C=C\\C(O)=O)C=C4F",2.903,1,1,5]
["S8387","MSC2530818","b4","L3900-29","in 10mM DMSO","CDK","Cell Cycle","MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.",340.81,"1883423-59-3",{"v":68,"d":"68.00"},199.52,"<1","N/A","http://selleckchem.com/products/msc2530818.html","C18H17ClN4O","free base","N/A","CC1=N[NH]C2=C1C=C(C=N2)C(=O)N3CCCC3C4=CC=C(Cl)C=C4",2.956,3,1,2]
["S8390","LXR-623 (WAY-252623)","c4","L3900-29","in 10mM DMSO","Liver X Receptor","Metabolism","LXR-623 (WAY-252623) is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.",422.78,"875787-07-8",{"v":84,"d":"84.00"},198.68,"<1","N/A","http://selleckchem.com/products/lxr-623-way-252623.html","C21H12ClF5N2","free base","N/A","FC1=CC=C(C=C1)C2=C3C=CC=C(C3=N[N]2CC4=CC=C(F)C=C4Cl)C(F)(F)F",7.227,1,0,4]
["S8397","Eltanexor (KPT-8602)","d4","L3900-29","in 10mM DMSO","CRM1","Transmembrane Transporters","Eltanexor (KPT-8602, ONO-7706，ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.",428.29,"1642300-52-4",{"v":85,"d":"85.00"},198.46,"<1","N/A","http://selleckchem.com/products/kpt-8602.html","C17H10F6N6O","free base","ONO-7706，ATG-016","NC(=O)/C(=C/[N]1C=NC(=N1)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3=CN=CN=C3",2.002,5,1,6]
["S8400","Mivebresib (ABBV-075)","e4","L3900-29","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain","Epigenetics","Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.",459.47,"1445993-26-9",{"v":91,"d":"91.00"},198.05,"<1","N/A","http://selleckchem.com/products/mivebresib-abbv-075.html","C22H19F2N3O4S","free base","N/A","CC[S](=O)(=O)NC1=CC(=C(OC2=C(F)C=C(F)C=C2)C=C1)C3=CN(C)C(=O)C4=C3C=C[NH]4",3.027,4,2,6]
["S8401","Erdafitinib (JNJ-42756493)","f4","L3900-29","in 10mM DMSO","Apoptosis related,c-Kit,c-RET,CSF-1R,FGFR,PDGFR,VEGFR","Angiogenesis","Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Erdafitinib also binds to RET (c-RET), CSF-1R, PDGFR-α/PDGFR-β, FLT4, Kit (c-Kit) and VEGFR-2 and induces cellular apoptosis.",446.54,"1346242-81-6",{"v":89,"d":"89.00"},199.31,"<1","N/A","http://selleckchem.com/products/jnj-42756493-erdafitinib.html","C25H30N6O2","free base","N/A","COC1=CC(=CC(=C1)N(CCNC(C)C)C2=CC3=NC(=CN=C3C=C2)C4=C[N](C)N=C4)OC",3.943,5,1,9]
["S8404","S49076","g4","L3900-29","in 10mM DMSO","Axl,c-Met,FGFR,Mertk","Protein Tyrosine Kinase","S49076 is a novel, potent inhibitor of Met (c-Met), AXL/MER, and FGFR1/2/3 with IC50 values below 20 nmol/L.",{"v":438.5,"d":"438.50"},"1265965-22-7",{"v":87,"d":"87.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/s49076.html","C22H22N4O4S","free base","N/A","O=C1CSC(=O)N1CC2=CC=C3NC(=O)C(=C\\C4=CC(=C[NH]4)CN5CCOCC5)/C3=C2",1.882,4,2,5]
["S8405","RRx-001","h4","L3900-29","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. RRx-001 triggers apoptosis and exhibits anticancer activity.",268.02,"925206-65-1",{"v":53,"d":"53.00"},197.75,"<1","N/A","http://selleckchem.com/products/rrx-001.html","C5H6BrN3O5","free base","N/A","[O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O",0.473,1,0,3]
["S8407","PF-06273340","a5","L3900-29","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively.",479.92,"1402438-74-7",{"v":95,"d":"95.00"},197.95,"<1","N/A","http://selleckchem.com/products/pf-06273340.html","C23H22ClN7O3","free base","N/A","CC(C)(CO)[N]1C=C(C(=O)C2=CN=CC(=C2)NC(=O)CC3=CC=C(Cl)C=N3)C4=CN=C(N)N=C14",1.582,6,3,7]
["S8412","Naquotinib(ASP8273)","b5","L3900-29","in 10mM DMSO","EGFR","Angiogenesis","Naquotinib (ASP8273) is an orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.",562.71,"1448232-80-1",{"v":52,"d":"52.00"},92.41,"<1","N/A","http://selleckchem.com/products/naquotinib-asp8273.html","C30H42N8O3","free base","N/A","CCC1=NC(=C(NC2=CC=C(C=C2)N3CCC(CC3)N4CCN(C)CC4)N=C1OC5CCN(C5)C(=O)C=C)C(N)=O",2.756,5,2,9]
["S8419","Stenoparib (E7449)","c5","L3900-29","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.",317.34,"1140964-99-3",{"v":4,"d":"4.00"},{"v":12.6,"d":"12.60"},"<1","N/A","http://selleckchem.com/products/e7449.html","C18H15N5O","free base","2X-121, MGI25036","O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5",1.436,3,2,2]
["S8432","Troglitazone (CS-045)","d5","L3900-29","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,PPAR","Metabolism","Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced ferroptosis and lipid peroxidation in Pfa1 cells.",441.54,"97322-87-7",{"v":88,"d":"88.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/troglitazone-cs-045.html","C24H27NO5S","free base","Rezulin, Romglizone, Prelay, Romozin","CC1=C(O)C(=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C)C",5.682,4,2,5]
["S8433","NS-398 (NS398)","e5","L3900-29","in 10mM DMSO","COX","Neuronal Signaling","NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.",314.36,"123653-11-2",{"v":62,"d":"62.00"},197.23,"<1","N/A","http://selleckchem.com/products/ns-398-ns398.html","C13H18N2O5S","free base","N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide","C[S](=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O",2.477,3,1,5]
["S8444","KPT 9274 ( ATG-019)","f5","L3900-29","in 10mM DMSO","NAMPT,PAK","Metabolism","KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.",610.62,"1643913-93-2",{"v":100,"d":"100.00"},163.77,"<1","N/A","http://selleckchem.com/products/kpt-9274.html","C35H29F3N4O3","free base","N/A","NC1=NC=C(C=C1)\\C=C\\C(=O)NCC2=CC3=C(O2)C(=CC(=C3)C4=CC=C(C=C4)C(=O)N5CCC(F)(F)CC5)C6=CC=C(F)C=C6",{"v":5.59,"d":"5.590"},4,2,7]
["S8452","BAY-876","g5","L3900-29","in 10mM DMSO","GLUT","Metabolism","BAY-876 is a potent and selective GLUT1 inhibitor (IC50=0.002 μM) with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4.",496.42,"1799753-84-6",{"v":99,"d":"99.00"},199.43,"<1","N/A","http://selleckchem.com/products/bay-876.html","C24H16F4N6O2","free base","N/A","CC1=C(NC(=O)C2=CC(=NC3=CC(=CC=C23)F)C(N)=O)C(=N[N]1CC4=CC=C(C=C4)C#N)C(F)(F)F",4.065,4,2,6]
["S8457","UK-371804 HCl","h5","L3900-29","in 10mM DMSO","Serine Protease","Proteases","UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).",422.29,"256476-36-5",{"v":30,"d":"30.00"},71.04,"<1","N/A","http://selleckchem.com/products/uk-371804-hcl.html","C14H16ClN5O4S.HCl","hydrochloride","UK-371804 HCl","Cl.CC(C)(N[S](=O)(=O)C1=CC2=C(C=C1)C(=CN=C2NC(N)=N)Cl)C(O)=O",1.326,4,3,6]
["S8459","TAK-063","a6","L3900-29","in 10mM DMSO","PDE","Metabolism","TAK-063 (Balipodect) is a novel and selective phosphodiesterase 10A(PDE10A) inhibitor with an IC50 of 0.30 nM.",428.42,"1238697-26-1",{"v":85,"d":"85.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/tak-063.html","C23H17FN6O2","free base","Balipodect","COC1=CN(N=C(C1=O)C2=CC=N[N]2C3=CC=CC=C3)C4=CC=C(C=C4F)[N]5C=CC=N5",3.983,5,0,5]
["S8464","Citarinostat (ACY-241)","b6","L3900-29","in 10mM DMSO","HDAC","Epigenetics","Citarinostat (ACY-241, HDAC-IN-2) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.",467.95,"1316215-12-9",{"v":41,"d":"41.00"},87.62,"<1","N/A","http://selleckchem.com/products/citarinostat-acy-241.html","C24H26ClN5O3","free base","HDAC-IN-2","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=C(Cl)C=CC=C3",4.582,4,2,11]
["S8481","SRT3025 HCl","c6","L3900-29","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.",{"v":606.2,"d":"606.20"},"2070015-26-6",{"v":100,"d":"100.00"},164.96,"<1","N/A","http://selleckchem.com/products/srt3025.html","C31H31N5O2S2.HCl","hydrochloride","N/A","Cl.COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=CC(=CN=C5S4)CN6CCCC6",5.849,5,1,10]
["S8483","CBL0137 HCl","d6","L3900-29","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8484","GSK2982772","e6","L3900-29","in 10mM DMSO","RIP kinase,TNF-alpha","Apoptosis","GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase (RIPK1) inhibitor with the IC50 value of 16 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.",{"v":377.4,"d":"377.40"},"1622848-92-3",{"v":75,"d":"75.00"},198.73,"<1","N/A","http://selleckchem.com/products/gsk2982772.html","C20H19N5O3","free base","N/A","CN1C(=O)C(COC2=CC=CC=C12)NC(=O)C3=N[NH]C(=N3)CC4=CC=CC=C4",1.639,5,2,4]
["S8490","Tanzisertib(CC-930)","f6","L3900-29","in 10mM DMSO","JNK","MAPK","Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.",{"v":484.9,"d":"484.90"},"899805-25-5(freebase)",{"v":89,"d":"89.00"},183.54,{"v":4,"d":"4.00"},8.25,"http://selleckchem.com/products/cc-930.html","C21H23F3N6O2.HCl","hydrochloride","JNK-930, JNKI-1","Cl.OC1CCC(CC1)NC2=NC3=C(C=N2)N=C(NC4=C(F)C=C(F)C=C4F)[N]3C5CCOC5",3.791,4,3,5]
["S8493","PD-166866 (PD166866)","g6","L3900-29","in 10mM DMSO","FGFR","Angiogenesis","PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.",396.44,"192705-79-6",{"v":14,"d":"14.00"},35.31,"<1","N/A","http://selleckchem.com/products/pd-166866.html","C20H24N6O3","free base","N/A","COC1=CC(=CC(=C1)C2=CC3=C(N=C(N)N=C3)N=C2NC(=O)NC(C)(C)C)OC",2.279,6,3,5]
["S8503","Fisogatinib (BLU-554)","h6","L3900-29","in 10mM DMSO","FGFR","Angiogenesis","Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.",503.38,"1707289-21-1",{"v":100,"d":"100.00"},198.66,"<1","N/A","http://selleckchem.com/products/blu-554.html","C24H24Cl2N4O4","free base","N/A","COC1=CC(=C(Cl)C(=C1Cl)C2=CC3=C(C=C2)N=C(NC4COCCC4NC(=O)C=C)N=C3)OC",4.229,6,2,7]
["S8511","Belizatinib (TSR-011)","a7","L3900-29","in 10mM DMSO","ALK,Trk receptor","Protein Tyrosine Kinase","\"Belizatinib (TSR-011) is a potent inhibitor of ALK (IC50=0.7 nM) and tropomyosin receptor kinase (TRK) (IC50 values less than 3 nM for TRK A, B, and C).\n\n\"",577.73,"1357920-84-3",{"v":100,"d":"100.00"},173.09,"<1","N/A","http://selleckchem.com/products/tsr-011-belizatinib.html","C33H44FN5O3","free base","N/A","CC(C)NC(=O)C1CCC(CC1)N2C(NC3=CC=C(CN4CCC(CC4)C(C)(C)O)C=C23)=NC(=O)C5=CC=C(F)C=C5",4.827,3,2,7]
["S8519","A-317491","b7","L3900-29","in 10mM DMSO","P2 Receptor","Neuronal Signaling","A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.",565.57,"475205-49-3",{"v":100,"d":"100.00"},176.81,"<1","N/A","http://selleckchem.com/products/a-317491.html","C33H27NO8","free base","N/A","OC(=O)C1=C(C=C(C(=O)N(CC2=CC(=CC=C2)OC3=CC=CC=C3)C4CCCC5=C4C=CC=C5)C(=C1)C(O)=O)C(O)=O",5.876,5,0,9]
["S8523","GSK2256098","c7","L3900-29","in 10mM DMSO","Apoptosis related,FAK","Angiogenesis","GSK2256098 is a potent, selective, reversible, and ATP competitive FAK kinase inhibitor with apparent Ki of 0.4 nM. GSK2256098 inhibits cancer cell growth and induces apoptosis.",414.89,"1224887-10-8",{"v":82,"d":"82.00"},197.64,"<1","N/A","http://selleckchem.com/products/gsk2256098.html","C20H23ClN6O2","free base","GTPL7939","CONC(=O)C1=CC=CC=C1NC2=C(Cl)C=NC(=C2)NC3=CC(=N[N]3C(C)C)C",{"v":3.82,"d":"3.820"},4,3,7]
["S8526","GDC-0575 (ARRY-575)","d7","L3900-29","in 10mM DMSO","Chk","Cell Cycle","GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2 nM.",378.27,"1196541-47-5",{"v":75,"d":"75.00"},198.27,"<1","N/A","http://www.selleckchem.com/products/gdc-0575.html","C16H20BrN5O","Free Base","RG7741","NC1CCCN(C1)C2=C(Br)C=NC3=C2C(=C[NH]3)NC(=O)C4CC4",1.621,2,3,3]
["S8534","Temuterkib (LY3214996)","e7","L3900-29","in 10mM DMSO","ERK","MAPK","Temuterkib (LY3214996) is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.",453.56,"1951483-29-6",{"v":27,"d":"27.00"},59.53,"<1","N/A","http://selleckchem.com/products/ly3214996.html","C22H27N7O2S","free base","N/A","C[N]1N=CC=C1NC2=NC(=CC=N2)C3=CC4=C(S3)C(C)(C)N(CCN5CCOCC5)C4=O",2.664,5,1,6]
["S8538","Ritlecitinib (PF-06651600)","f7","L3900-29","in 10mM DMSO","JAK","JAK/STAT","Ritlecitinib (PF-06651600) is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.",285.34,"1792180-81-4",{"v":57,"d":"57.00"},199.76,"N/A","N/A","http://selleckchem.com/products/pf-06651600.html","C15H19N5O","free base","N/A","CC1CCC(CN1C(=O)C=C)NC2=C3C=C[NH]C3=NC=N2",1.854,3,2,3]
["S8539","TAS-102","g7","L3900-29","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.",435.76,"733030-01-8",{"v":100,"d":"100.00"},114.74,{"v":15,"d":"15.00"},17.21,"http://selleckchem.com/products/tas-102.html","C10H11F3N2O5.0.5C9H11ClN4O2.0.5HCl","hydrochloride","Trifluridine-Tipiracil Hydrochloride Mixture","Cl.OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F.OCC3OC(CC3O)N4C=C(C(=O)NC4=O)C(F)(F)F.ClC5=C(CN6CCCC6=N)NC(=O)NC5=O",-1.951,8,8,8]
["S8540","Voxelotor (GBT440)","h7","L3900-29","in 10mM DMSO","Others","Others","Voxelotor (GBT440, GTx011) is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity.",337.37,"1446321-46-5",{"v":67,"d":"67.00"},{"v":198.6,"d":"198.60"},"<1","N/A","http://selleckchem.com/products/gbt440.html","C19H19N3O3","free base","GTx011","CC(C)[N]1N=CC=C1C2=NC=CC=C2COC3=CC=CC(=C3C=O)O",3.378,4,1,6]
["S8555","Asciminib (ABL001)","a8","L3900-29","in 10mM DMSO","Bcr-Abl","Angiogenesis","Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of 0.5-0.8 nM and selectivity to the myristoyl pocket of ABL1.",449.84,"1492952-76-7",{"v":89,"d":"89.00"},197.85,"N/A","N/A","http://selleckchem.com/products/asciminib-abl001.html","C20H18ClF2N5O3","free base","N/A","OC1CCN(C1)C2=C(C=C(C=N2)C(=O)NC3=CC=C(OC(F)(F)Cl)C=C3)C4=CC=N[NH]4",4.196,4,3,6]
["S8558","Tofogliflozin(CSG 452)","b8","L3900-29","in 10mM DMSO","SGLT","GPCR & G Protein","Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.",404.45,"1201913-82-7",{"v":84,"d":"84.00"},207.69,{"v":4,"d":"4.00"},9.89,"http://selleckchem.com/products/tofogliflozin-csg-452.html","C22H26O6.H2O","hydrate","N/A","O.CCC1=CC=C(CC2=CC3=C(COC34OC(CO)C(O)C(O)C4O)C=C2)C=C1",{"v":1.92,"d":"1.920"},2,4,4]
["S8560","Seletalisib (UCB-5857)","c8","L3900-29","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).",482.85,"1362850-20-1",{"v":97,"d":"97.00"},200.89,"<1","N/A","http://www.selleckchem.com/products/seletalisib-ucb-5857.html","C23H14ClF3N6O","Free Base","N/A","[O-][N+]1=CC=CC(=C1)C2=NC3=C(Cl)C=CC=C3C=C2C(NC4=C5N=CC=CC5=NC=N4)C(F)(F)F",4.436,4,1,5]
["S8562","IRAK4-IN-2","d8","L3900-29","in 10mM DMSO","IL Receptor,IRAK,TLR","Immunology & Inflammation","IRAK4-IN-2 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades.",417.42,"1801343-74-7",{"v":30,"d":"30.00"},71.87,"<1","N/A","https://www.selleckchem.com/products/irak4-in-2.html","C21H19N7O3","free base","N/A","NC1=CC=C(C=N1)C2=CC=CC(=N2)C(=O)NC3=CC4=C(N=C3)N=C(O4)N5CCOCC5",1.443,7,2,4]
["S8564","Verubecestat (MK-8931)","e8","L3900-29","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.",409.41,"1286770-55-5",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/verubecestat.html","C17H17F2N5O3S","free base","N/A","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3",1.314,4,2,3]
["S8565","Omarigliptin (MK-3102)","f8","L3900-29","in 10mM DMSO","DPP","Proteases","Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).",398.43,"1226781-44-7",{"v":79,"d":"79.00"},198.28,"<1","N/A","http://selleckchem.com/products/omarigliptin-mk-3102.html","C17H20F2N4O3S","free base","N/A","C[S](=O)(=O)[N]1C=C2CN(CC2=N1)C3COC(C(N)C3)C4=C(F)C=CC(=C4)F",1.098,4,1,3]
["S8567","Tucidinostat (Chidamide)","g8","L3900-29","in 10mM DMSO","HDAC","Epigenetics","Tucidinostat (Chidamide, HBI-8000, CS-055) is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.",390.41,"1616493-44-7",{"v":78,"d":"78.00"},199.79,"<1","N/A","http://selleckchem.com/products/tucidinostat-chidamide.html","C22H19FN4O2","free base","HBI-8000, CS-055","NC1=C(NC(=O)C2=CC=C(CNC(=O)\\C=C\\C3=CC=CN=C3)C=C2)C=C(F)C=C1",2.182,3,3,6]
["S8570","RXDX-106 (CEP-40783)","h8","L3900-29","in 10mM DMSO","Axl,c-Met,Mertk,Tyro3","Protein Tyrosine Kinase","RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.",588.56,"1437321-24-8",{"v":10,"d":"10.00"},16.99,"<1","N/A","http://selleckchem.com/products/rxdx-106-cep-40783.html","C31H26F2N4O6","free base","N/A","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=C(F)C=C(NC(=O)C4=CN(C(C)C)C(=O)N(C4=O)C5=CC=C(F)C=C5)C=C3",4.572,7,1,8]
["S8572","Amcasertib (BBI503)","a9","L3900-29","in 10mM DMSO","Stemness kinase","Stem Cells & Wnt","Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.",539.69,"1129403-56-0",{"v":14,"d":"14.00"},25.94,"<1","N/A","http://selleckchem.com/products/amcasertib-bbi503.html","C31H33N5O2S","free base","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)\\C=C/2C(=O)NC3=CC=C(C=C23)C4=CSC(=N4)C5=CC=CC=C5",5.119,3,3,9]
["S8573","Sitravatinib (MGCD516)","b9","L3900-29","in 10mM DMSO","Axl,c-Kit,Ephrin receptor,Trk receptor,VEGFR","Protein Tyrosine Kinase","Sitravatinib (MGCD516, MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.",629.68,"1123837-84-2",{"v":100,"d":"100.00"},158.81,"<1","N/A","http://selleckchem.com/products/sitravatinib-mgcd516.html","C33H29F2N5O4S","free base","MG-516","COCCNCC1=CC=C(N=C1)C2=CC3=C(S2)C(=CC=N3)OC4=CC=C(NC(=O)C5(CC5)C(=O)NC6=CC=C(F)C=C6)C=C4F",5.029,6,3,12]
["S8578","PRN1371","c9","L3900-29","in 10mM DMSO","CSF-1R,FGFR","Angiogenesis","PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.",561.46,"1802929-43-6",{"v":100,"d":"100.00"},178.11,"<1","N/A","http://selleckchem.com/products/prn1371.html","C26H30Cl2N6O4","free base","N/A","CNC1=NC=C2C=C(C(=O)N(CCCN3CCN(CC3)C(=O)C=C)C2=N1)C4=C(Cl)C(=CC(=C4Cl)OC)OC",3.438,6,1,9]
["S8580","COTI-2","d9","L3900-29","in 10mM DMSO","p53","Apoptosis","COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.",366.48,"1039455-84-9",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/coti-2.html","C19H22N6S","free base","N/A","S=C(N\\N=C/1CCCC2=C1N=CC=C2)N3CCN(CC3)C4=NC=CC=C4",3.825,3,1,4]
["S8581","Serabelisib (TAK-117)","e9","L3900-29","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.",363.37,"1268454-23-4",{"v":16,"d":"16.00"},44.03,"<1","N/A","http://selleckchem.com/products/tak-117-ink-1117-mln-1117.html","C19H17N5O3","free base","INK-1117, MLN-1117","NC1=NC2=C(O1)C=CC(=C2)C3=C[N]4C(=NC=C4C(=O)N5CCOCC5)C=C3",0.939,5,1,2]
["S8583","Repotrectinib (TPX-0005)","f9","L3900-29","in 10mM DMSO","ALK,ROS1,Src,Trk receptor","Protein Tyrosine Kinase","Repotrectinib (TPX-0005) is a novel ALK/ROS1/TRK inhibitor with the IC50 values of 1.01 nM for WT ALK, 1.26 nM for ALK(G1202R), and 1.08 nM for ALK(L1196M); also a potent SRC inhibitor (IC50 5.3 nM).",355.37,"1802220-02-5",{"v":70,"d":"70.00"},196.98,"<1","N/A","http://selleckchem.com/products/tpx-0005.html","C18H18FN5O2","free base","N/A","CC1CNC(=O)C2=C3N=C(NC(C)C4=C(O1)C=CC(=C4)F)C=C[N]3N=C2",2.005,4,2,0]
["S8589","SF2523","g9","L3900-29","in 10mM DMSO","DNA-PK,Epigenetic Reader Domain,mTOR,PI3K","PI3K/Akt/mTOR","SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.",371.41,"1174428-47-7",{"v":29,"d":"29.00"},78.08,"<1","N/A","http://selleckchem.com/products/sf2523.html","C19H17NO5S","free base","N/A","O=C1C=C(OC2=C1SC=C2C3=CC=C4OCCOC4=C3)N5CCOCC5",3.081,5,0,2]
["S8592","Pamiparib (BGB-290)","h9","L3900-29","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Pamiparib (BGB-290) is a potent and selective inhibitor of PARP1 and PARP2 with IC50 values of 0.83 and 0.11 nM, respectively in biochemical assays. It shows high selectivity over other PARP enzymes.",298.31,"1446261-44-4",{"v":59,"d":"59.00"},197.78,"<1","N/A","http://www.selleckchem.com/products/bgb-290.html","C16H15FN4O","Free Base","N/A","CC12CCCN1CC3=NNC(=O)C4=CC(=CC5=C4C3=C2[NH]5)F",2.078,2,2,0]
["S8594","Tirofiban Hydrochloride","a10","L3900-29","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.",495.07,"150915-40-5",{"v":95,"d":"95.00"},191.89,{"v":95,"d":"95.00"},191.89,"http://selleckchem.com/products/tirofiban-hydrochlorid.html","C22H36N2O5S.HCl.H2O","hydrochloride hydrate","MK-383 Hydrochloride","O.Cl.CCCC[S](=O)(=O)NC(CC1=CC=C(OCCCCC2CCNCC2)C=C1)C(O)=O",0.922,4,2,14]
["S8598","S 38093","b10","L3900-29","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","S 38093 is a histamine H3 antagonist/inverse agonist with a moderate affinity for rat, mouse and human H3 receptors (Ki = 8.8, 1.44 and 1.2 μM, respectively) and no affinity for other histaminergic receptors.",288.38,"862896-30-8",{"v":57,"d":"57.00"},197.66,"<1","N/A","http://selleckchem.com/products/S-38093.html","C17H24N2O2","free base","N/A","NC(=O)C1=CC=C(OCCCN2CC3CCCC3C2)C=C1",2.201,2,1,6]
["S8603","NGP 555","c10","L3900-29","in 10mM DMSO","Secretase","Proteases","NGP 555 is a small-molecule modulator of  γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.",406.52,"1304630-27-0",{"v":40,"d":"40.00"},{"v":98.4,"d":"98.40"},"<1","N/A","http://selleckchem.com/products/npg-555.html","C23H23FN4S","free base","N/A","CCC1=C(C)C=C(C)C(=C1)NC2=NC(=CS2)C3=CC=C([N]4C=NC(=C4)C)C(=C3)F",6.396,2,1,5]
["S8605","C188-9","d10","L3900-29","in 10mM DMSO","STAT","JAK/STAT","C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.",471.52,"432001-19-9",{"v":94,"d":"94.00"},199.36,"<1","N/A","http://selleckchem.com/products/c188-9.html","C27H21NO5S","free base","TTI 101","COC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=C(O)C3=CC=CC=C23)C4=C(O)C=CC5=C4C=CC=C5",5.152,3,3,5]
["S8608","Adenosine Dialdehyde (ADOX)","e10","L3900-29","in 10mM DMSO","SAM MTase,Transferase","Metabolism","Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.",265.23,"34240-05-6",{"v":19,"d":"19.00"},71.64,{"v":3,"d":"3.00"},11.31,"http://selleckchem.com/products/adenosine-dialdehyde-adox.html","C10H11N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C(OC(CO)C=O)C=O",-1.346,6,2,6]
["S8609","Derazantinib(ARQ-087)","f10","L3900-29","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT.",468.57,"1234356-69-4",{"v":93,"d":"93.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/derazantinib.html","C29H29FN4O","Free Base","N/A","COCCNCCC1=CC(=CC=C1)NC2=NC3=C(CC(C4=CC=CC=C4F)C5=C3C=CC=C5)C=N2",5.887,3,2,9]
["S8611","Vorasidenib (AG-881)","g10","L3900-29","in 10mM DMSO","Dehydrogenase","Metabolism","Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2).",414.74,"1644545-52-7",{"v":82,"d":"82.00"},197.71,"<1","N/A","http://selleckchem.com/products/ag-881.html","C14H13ClF6N6","free base","N/A","CC(NC1=NC(=NC(=N1)C2=CC=CC(=N2)Cl)NC(C)C(F)(F)F)C(F)(F)F",5.146,4,2,7]
["S8615","Sodium dichloroacetate (DCA)","h10","L3900-29","in 10mM DMSO","Apoptosis related,Dehydrogenase,NKCC,ROS","Metabolism","Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.",150.92,"2156-56-1",{"v":30,"d":"30.00"},198.78,{"v":30,"d":"30.00"},198.78,"http://selleckchem.com/products/sodium-dichloroacetate-dca.html","C2HCl2O2.Na","sodium salt","Dichloroacetic acid, bichloroacetic acid, BCA","[Na]OC(=O)C(Cl)Cl",1.081,2,0,2]
["S8629","Linrodostat (BMS-986205)","a11","L3900-29","in 10mM DMSO","IDO/TDO","Metabolism","Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.",410.91,"1923833-60-6",{"v":82,"d":"82.00"},199.56,"<1","N/A","https://www.selleckchem.com/products/bms-986205.html","C24H24ClFN2O","free base","ONO-7701","CC(C1CCC(CC1)C2=CC=NC3=C2C=C(F)C=C3)C(=O)NC4=CC=C(Cl)C=C4",6.125,2,1,4]
["S8637","Ipragliflozin (ASP1941)","b11","L3900-29","in 10mM DMSO","SGLT","GPCR & G Protein","Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.",404.45,"761423-87-4",{"v":80,"d":"80.00"},{"v":197.8,"d":"197.80"},"<1","N/A","http://selleckchem.com/products/ipragliflozin-asp-1941.html","C21H21FOS","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=CC(=C(F)C=C2)CC3=CC4=C(S3)C=CC=C4",{"v":2.35,"d":"2.350"},1,4,4]
["S8640","Reparixin (Repertaxin)","c11","L3900-29","in 10mM DMSO","CXCR","Immunology & Inflammation","Reparixin (Repertaxin, DF 1681Y) is a potent and specific inhibitor of CXCR1 with IC50 of 1 nM. Reparixin (Repertaxin) inhibits PMN migration induced by CXCL8 (IC50 = 1 nM) and rodent PMN chemotaxis induced by CXCL1 and CXCL2. Repertaxin inhibits the response of human PMN to CXCL1, which interacts with CXCR2 (IC50 = 400 nM).",283.39,"266359-83-5",{"v":56,"d":"56.00"},197.61,"<1","N/A","http://selleckchem.com/products/reparixin-repertaxin.html","C14H21NO3S","free base","DF 1681Y","CC(C)CC1=CC=C(C=C1)C(C)C(=O)N[S](C)(=O)=O",{"v":2.76,"d":"2.760"},3,1,5]
["S8648","ACY-738","d11","L3900-29","in 10mM DMSO","HDAC","Epigenetics","ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.",270.29,"1375465-91-0",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/acy-738.html","C14H14N4O2","free base","N/A","ONC(=O)C1=CN=C(NC2(CC2)C3=CC=CC=C3)N=C1",1.325,3,2,4]
["S8657","PF-06840003","e11","L3900-29","in 10mM DMSO","IDO/TDO","Metabolism","PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.",232.21,"198474-05-4",{"v":46,"d":"46.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pf-06840003.html","C12H9FN2O2","free base","EOS200271","FC1=CC=C2[NH]C=C(C3CC(=O)NC3=O)C2=C1",1.201,2,2,1]
["S8664","Pemrametostat (GSK3326595)","f11","L3900-29","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.",452.55,"1616392-22-3",{"v":90,"d":"90.00"},198.87,"<1","N/A","http://selleckchem.com/products/gsk3326595-epz015938.html","C24H32N6O3","free base","EPZ015938","CC(=O)N1CCC(CC1)NC2=CC(=NC=N2)C(=O)NCC(O)CN3CCC4=C(C3)C=CC=C4",0.692,4,3,7]
["S8666","Elimusertib (BAY-1895344) hydrochloride","g11","L3900-29","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.",411.89,"1876467-74-1(free base)",{"v":82,"d":"82.00"},199.08,{"v":82,"d":"82.00"},199.08,"https://www.selleckchem.com/products/bay-1895344-hcl.html","C20H22ClN7O","hydrochloride","BAY-1895344 HCl","Cl.CC1COCCN1C2=CC(=C3C=CN=C(C4=CC=N[NH]4)C3=N2)C5=CC=N[N]5C",3.156,5,1,3]
["S8672","Tenalisib (RP6530)","h11","L3900-29","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.",415.42,"1639417-53-0",{"v":75,"d":"75.00"},180.54,"<1","N/A","http://selleckchem.com/products/tenalisib-rp6530.html","C23H18FN5O2","free base","N/A","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=C(C(=O)C4=CC=CC=C4O3)C5=CC=CC(=C5)F",{"v":4.07,"d":"4.070"},5,2,5]
["S8673","ONC212","a2","L3900-30","in 10mM DMSO","GPR","GPCR & G Protein","ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132. ONC212 is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity.",440.46,"1807861-48-8",{"v":88,"d":"88.00"},199.79,"<1","N/A","http://selleckchem.com/products/onc212.html","C24H23F3N4O","free base","N/A","FC(F)(F)C1=CC=C(CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25)C=C1",3.668,2,0,5]
["S8675","H3B-6527","b2","L3900-30","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3 (IC50 values of 320, 1,290 and 1,060 nM respectively).",629.54,"1702259-66-2",{"v":50,"d":"50.00"},79.42,"<1","N/A","http://selleckchem.com/products/h3b-6527.html","C29H34Cl2N8O4","free base","N/A","CCN1CCN(CC1)C2=CC(=C(NC3=CC(=NC=N3)N(C)C(=O)NC4=C(Cl)C(=CC(=C4Cl)OC)OC)C=C2)NC(=O)C=C",{"v":5.16,"d":"5.160"},6,3,10]
["S8676","Glumetinib (SCC244)","c2","L3900-30","in 10mM DMSO","c-Met,RON","Protein Tyrosine Kinase","Glumetinib (SCC244) is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3.",459.48,"1642581-63-2",{"v":11,"d":"11.00"},23.94,"<1","N/A","http://www.selleck.cn/products/glumetinib.html","C21H17N9O2S","free base","N/A","C[N]1C=C(C=N1)C2=C[N]3C(=NC=C3[S](=O)(=O)[N]4N=CC5=NC=C(C=C45)C6=C[N](C)N=C6)C=C2",1.725,7,0,4]
["S8680","AZD1390","d2","L3900-30","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.",477.57,"2089288-03-7",{"v":14,"d":"14.00"},29.32,"<1","N/A","http://selleckchem.com/products/azd1390.html","C27H32FN5O2","free base","N/A","CC(C)N1C(=O)N(C)C2=C1C3=CC(=C(F)C=C3N=C2)C4=CC=C(OCCCN5CCCCC5)N=C4",4.231,4,0,7]
["S8685","AS1517499","e2","L3900-30","in 10mM DMSO","STAT","JAK/STAT","AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.",397.86,"919486-40-1",{"v":79,"d":"79.00"},198.56,"<1","N/A","http://selleckchem.com/products/as1517499.html","C20H20ClN5O2","free base","N/A","NC(=O)C1=CN=C(NCCC2=CC=C(O)C(=C2)Cl)N=C1NCC3=CC=CC=C3",3.641,3,4,8]
["S8689","Abequolixron (RGX-104)","f2","L3900-30","in 10mM DMSO","Liver X Receptor","Metabolism","Abequolixron (RGX-104) is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene.",632.54,"610318-03-1",{"v":100,"d":"100.00"},158.09,"<1","N/A","http://www.selleckchem.com/products/rgx-104.html","C34H34Cl2F3NO3","Free Base","N/A","Cl.CC(CCOC1=CC=CC(=C1)CC(O)=O)N(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(=C4Cl)C(F)(F)F",{"v":5.85,"d":"5.850"},2,0,14]
["S8698","GLPG1837","g2","L3900-30","in 10mM DMSO","CFTR","Transmembrane Transporters","GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.",348.42,"1654725-02-6",{"v":69,"d":"69.00"},198.04,"<1","N/A","http://selleckchem.com/products/glpg1837.html","C16H20N4O3S","free base","ABBV-974","CC1(C)CC2=C(SC(=C2C(N)=O)NC(=O)C3=N[NH]C=C3)C(C)(C)O1",1.611,4,3,3]
["S8699","SNS-314 Mesylate","h2","L3900-30","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.",527.04,"1146618-41-8",{"v":100,"d":"100.00"},189.74,"<1","N/A","http://selleckchem.com/products/sns-314.html","C18H15ClN6OS2.CH4O3S","Mesylate","N/A","ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.953,4,3,6]
["S8701","MK-8353 (SCH900353)","a3","L3900-30","in 10mM DMSO","ERK","MAPK","MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).",691.84,"1184173-73-6",{"v":50,"d":"50.00"},72.27,"<1","N/A","http://www.selleck.cn/products/mk-8353-sch900353.html","C37H41N9O3S","Free Base","N/A","CSC1(CCN(CC(=O)N2CCC(=CC2)C3=CC=C(C=C3)C4=N[N](C)C=N4)C1)C(=O)NC5=CC=C6[NH]N=C(C7=CC=C(OC(C)C)N=C7)C6=C5",4.176,7,2,10]
["S8711","Nemtabrutinib (ARQ 531)","b3","L3900-30","in 10mM DMSO","BTK","Angiogenesis","Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.",478.93,"2095393-15-8",{"v":95,"d":"95.00"},198.36,"<1","N/A","https://www.selleckchem.com/products/arq531.html","C25H23ClN4O4","free base","MK-1026","OCC1CCC(CO1)NC2=C3C(=NC=N2)[NH]C=C3C(=O)C4=CC=C(OC5=CC=CC=C5)C=C4Cl",4.368,5,3,7]
["S8714","INCB057643","c3","L3900-30","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones.",415.46,"1820889-23-3",{"v":83,"d":"83.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/incb057643.html","C20H21N3O5S","Free Base","N/A","CN1C=C(C2=C([NH]C=C2)C1=O)C3=CC(=CC4=C3OC(C)(C)C(=O)N4C)[S](C)(=O)=O",1.114,5,1,2]
["S8721","PDGFR inhibitor 1","d3","L3900-30","in 10mM DMSO","c-Kit,CSF-1R,PDGFR,VEGFR","Protein Tyrosine Kinase","PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of Kit (c-Kit) and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.",489.47,"1225278-16-9",{"v":97,"d":"97.00"},198.17,"<1","N/A","https://www.selleckchem.com/products/pdgfr-inhibitor-1.html","C26H21F2N5O3","free base/salt","N/A","C[N]1C=C(C=N1)C2=NC=CC(=C2)OC3=CC(=C(NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)C=C3F)F",3.841,5,2,7]
["S8723","ABBV-744","e3","L3900-30","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.",491.55,"2138861-99-9",{"v":98,"d":"98.00"},199.37,"<1","N/A","http://www.selleckchem.com/products/abbv-744.html","C28H30FN3O4","Free Base","N/A","CCNC(=O)C1=CC2=C([NH]1)C(=O)N(C)C=C2C3=C(OC4=C(C)C=C(F)C=C4C)C=CC(=C3)C(C)(C)O",{"v":4.36,"d":"4.360"},3,2,6]
["S8726","Anlotinib (AL3818) dihydrochloride","f3","L3900-30","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Anlotinib (AL3818) is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. It has broad-spectrum antitumor potential in clinical trials. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.",480.36,"1360460-82-7",{"v":96,"d":"96.00"},199.85,{"v":96,"d":"96.00"},199.85,"http://selleckchem.com/products/anlotinib-al3818.html","C23H22FN3O3.2HCl","dihydrochloride","N/A","Cl.Cl.COC1=C(OCC2(N)CC2)C=C3N=CC=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.469,4,2,6]
["S8727","Atuveciclib (BAY-1143572)","g3","L3900-30","in 10mM DMSO","CDK","Cell Cycle","Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.",387.43,"1414943-88-6",{"v":77,"d":"77.00"},198.75,"<1","N/A","http://www.selleckchem.com/products/atuveciclib-bay-1143572.html","C18H18FN5O2S","Free Base","N/A","COC1=CC(=CC=C1C2=NC(=NC=N2)NC3=CC(=CC=C3)C[S](C)(=N)=O)F",3.699,5,1,6]
["S8729","AZ32","h3","L3900-30","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.",328.37,"2288709-96-4",{"v":66,"d":"66.00"},200.99,"<1","N/A","http://www.selleckchem.com/products/az32.html","C20H16N4O","Free Base","N/A","CNC(=O)C1=CC=C(C=C1)C2=CN=C3C=NC(=C[N]23)C4=CC=CC=C4",2.521,3,1,3]
["S8731","IACS-010759 (IACS-10759)","a4","L3900-30","in 10mM DMSO","OXPHOS","Apoptosis","IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.",562.56,"1570496-34-2",{"v":27,"d":"27.00"},47.99,"<1","N/A","http://www.selleckchem.com/products/iacs-010759-iacs-10759.html","C25H25F3N6O4S","Free Base","N/A","CC1=NC(=N[N]1CC2=CC(=CC=C2)N3CCC(CC3)[S](C)(=O)=O)C4=NC(=NO4)C5=CC=C(OC(F)(F)F)C=C5",4.909,8,0,8]
["S8736","Verinurad (RDEA3170)","b4","L3900-30","in 10mM DMSO","OAT","Transmembrane Transporters","Verinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter with an IC50 of 25 nM for inhibiting transport activity of human URAT1. It inhibits the related URAT1 homologs OAT4 and OAT1 with approximately 200-fold lower affinity compared to URAT1 with IC50 values of 5.9 µM and 4.6 µM, respectively.",348.42,"1352792-74-5",{"v":70,"d":"70.00"},200.91,"<1","N/A","http://selleckchem.com/products/verinurad-rdea3170.html","C20H16N2O2S","free base","N/A","CC(C)(SC1=C(C=NC=C1)C2=C3C=CC=CC3=C(C=C2)C#N)C(O)=O",3.804,2,0,4]
["S8738","Bimiralisib (PQR309)","c4","L3900-30","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.",411.38,"1225037-39-7",{"v":6,"d":"6.00"},14.59,"<1","N/A","http://www.selleckchem.com/products/pqr309-bimiralisib.html","C17H20F3N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C(=C1)C(F)(F)F",1.891,6,1,4]
["S8739","PLX51107","d4","L3900-30","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range).",438.48,"1627929-55-8",{"v":88,"d":"88.00"},200.69,"<1","N/A","http://www.selleck.cn/products/plx51107.html","C26H22N4O3","Free Base","N/A","CC([N]1C=C(C2=CC=C(C=C2)C(O)=O)C3=NC=C(C=C13)C4=C(C)ON=C4C)C5=CC=CC=N5",4.288,5,0,5]
["S8741","Avitinib (AC0010)","e4","L3900-30","in 10mM DMSO","BTK,EGFR","Protein Tyrosine Kinase","Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.",487.53,"1557267-42-1",{"v":97,"d":"97.00"},198.96,"<1","N/A","http://www.selleckchem.com/products/avitinib-ac0010.html","C26H26FN7O2","Free Base","Abivertinib","CN1CCN(CC1)C2=C(F)C=C(NC3=NC4=C(C=C[NH]4)C(=N3)OC5=CC(=CC=C5)NC(=O)C=C)C=C2",4.857,4,3,7]
["S8745","Naporafenib (LXH254)","f4","L3900-30","in 10mM DMSO","Raf","MAPK","Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.",502.49,"1800398-38-2",{"v":100,"d":"100.00"},199.01,"<1","N/A","http://www.selleckchem.com/products/lxh254.html","C25H25F3N4O4","Free Base","N/A","CC1=CC=C(NC(=O)C2=CC(=NC=C2)C(F)(F)F)C=C1C3=CC(=NC(=C3)OCCO)N4CCOCC4",4.061,5,2,8]
["S8749","MBQ-167","g4","L3900-30","in 10mM DMSO","Rho","Cell Cycle","MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.",338.41,"2097938-73-1",{"v":68,"d":"68.00"},200.94,"<1","N/A","http://www.selleckchem.com/products/mbq-167.html","C22H18N4","Free Base","N/A","CC[N]1C2=C(C=CC=C2)C3=CC(=CC=C13)[N]4N=NC=C4C5=CC=CC=C5",5.446,2,0,3]
["S8752","leniolisib (CDZ 173)","h4","L3900-30","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Leniolisib (CDZ 173) is a potent PI3Kδ selective inhibitor with biochemical IC50 values of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.",450.46,"1354690-24-6",{"v":90,"d":"90.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/leniolisib-cdz-173.html","C21H25F3N6O2","Free Base","N/A","CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(OC)N=C4)C(F)(F)F",{"v":2.65,"d":"2.650"},5,1,6]
["S8753","INCB054329","a5","L3900-30","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","INCB054329 (INCB-054329, INCB-54329) is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM for BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2, respectively.",348.36,"1628607-64-6",{"v":70,"d":"70.00"},200.94,"˂1","N/A","http://www.selleck.cn/products/incb054329.html","C19H16N4O3","Free Base","INCB-054329, INCB-54329","CC1=C(C(=NO1)C)C2=CC=C3NC(=O)N4C(COC2=C34)C5=NC=CC=C5",1.884,5,1,2]
["S8754","Alofanib (RPT835)","b5","L3900-30","in 10mM DMSO","FGFR","Angiogenesis","Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.",{"v":413.4,"d":"413.40"},"1612888-66-0",{"v":83,"d":"83.00"},200.77,"<1","N/A","http://www.selleckchem.com/products/alofanib-rpt835.html","C19H15N3O6S","Free Base","N/A","CC1=CC(=C(N[S](=O)(=O)C2=CC=CC(=C2)C(O)=O)C=C1C3=CC=CN=C3)[N+]([O-])=O",2.695,4,1,6]
["S8755","AZ304","c5","L3900-30","in 10mM DMSO","Raf","MAPK","AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies.",451.52,"942507-42-8",{"v":90,"d":"90.00"},199.33,"<1","N/A","http://www.selleck.cn/products/az304.html","C27H25N5O2","free base","N/A","COC1=CC2=C(C=C1)C(=NC=N2)NC3=CC(=CC=C3C)NC(=O)C4=CC=CC(=C4)C(C)(C)C#N",5.524,4,2,6]
["S8757","Ripretinib (DCC-2618)","d5","L3900-30","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.",510.36,"1442472-39-0",{"v":100,"d":"100.00"},195.94,"<1","N/A","http://www.selleckchem.com/products/ripretinib-dcc-2618.html","C24H21BrFN5O2","Free Base","N/A","CCN1C(=O)C(=CC2=C1C=C(NC)N=C2)C3=C(Br)C=C(F)C(=C3)NC(=O)NC4=CC=CC=C4",4.129,3,3,5]
["S8759","S55746","e5","L3900-30","in 10mM DMSO","Bcl-2","Apoptosis","S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.",710.82,"1448584-12-0",{"v":100,"d":"100.00"},140.68,"<1","N/A","http://www.selleckchem.com/products/s55746-s055746-bcl201.html","C43H42N4O6","Free Base","S 055746,BCL201","OC1=CC=C(C=C1)N(C(=O)C2=C3CCCC[N]3C(=C2)C4=C(C=C5OCOC5=C4)C(=O)N6CC7=C(CC6CN8CCOCC8)C=CC=C7)C9=CC=CC=C9",6.817,5,1,7]
["S8760","Iberdomide (CC220)","f5","L3900-30","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,Immunology & Inflammation related","Immunology & Inflammation","Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.",{"v":449.5,"d":"449.50"},"1323403-33-3",{"v":90,"d":"90.00"},200.22,"<1","N/A","http://www.selleck.cn/products/iberdomide.html","C25H27N3O5","free base","N/A","O=C1CCC(N2CC3=C(OCC4=CC=C(CN5CCOCC5)C=C4)C=CC=C3C2=O)C(=O)N1",{"v":1.56,"d":"1.560"},5,1,6]
["S8761","Adavivint (SM04690)","g5","L3900-30","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.",505.55,"1467093-03-3",{"v":30,"d":"30.00"},59.34,"<1","N/A","http://www.selleckchem.com/products/adavivint.html","C29H24FN7O","Free Base","Lorecivivint","CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C([NH]N=C3C4=NC5=C([NH]4)C(=CN=C5)C6=CC=CC(=C6)F)C=C2",4.779,5,3,6]
["S8765","Abrocitinib (PF-04965842)","h5","L3900-30","in 10mM DMSO","JAK","JAK/STAT","Abrocitinib (PF-04965842) is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.",323.41,"1622902-68-4",{"v":65,"d":"65.00"},200.98,"<1","N/A","http://www.selleck.cn/products/pf-04965842.html","C14H21N5O2S","free base","N/A","CCC[S](=O)(=O)NC1CC(C1)N(C)C2=C3C=C[NH]C3=NC=N2",1.101,4,2,6]
["S8769","Tinostamustine(EDO-S101)","a6","L3900-30","in 10mM DMSO","HDAC","Epigenetics","Tinostamustine(EDO-S101) is a first-in-class alkylating deacetylase inhibitor with IC50 values of 9 nM, 9 nM, 25 nM and 107 nM for HDAC1, HDAC2, HDAC3 and HDAC8 (Class 1 HDACs) respectively and 6 nM, 72 nM for HDAC6 and HDAC10 (Class II HDACs).",415.36,"1236199-60-2",{"v":14,"d":"14.00"},33.71,"<1","N/A","http://www.selleck.cn/products/tinostamustine.html","C19H28Cl2N4O2","Free Base","N/A","C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCCCCC(=O)NO",{"v":4.36,"d":"4.360"},2,1,12]
["S8770","Lanifibranor (IVA-337)","b6","L3900-30","in 10mM DMSO","PPAR","Metabolism","Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively.",434.92,"927961-18-0",{"v":87,"d":"87.00"},200.04,"<1","N/A","http://www.selleckchem.com/products/lanifibranor-iva-337.html","C19H15ClN2O4S2","Free Base","N/A","OC(=O)CCCC1=CC2=CC(=CC=C2[N]1[S](=O)(=O)C3=CC4=C(C=C3)N=CS4)Cl",4.676,4,0,6]
["S8771","IDF-11774","c6","L3900-30","in 10mM DMSO","HIF","Angiogenesis","IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.",368.51,"1429054-28-3",{"v":15,"d":"15.00"},{"v":40.7,"d":"40.70"},"<1","N/A","http://www.selleckchem.com/products/idf-11774.html","C23H32N2O2","Free Base","N/A","CN1CCN(CC1)C(=O)COC2=CC=C(C=C2)[C]34C[CH]5[CH2]C([CH2][CH](C5)C3)C4",3.446,2,0,4]
["S8772","LY 3200882","d6","L3900-30","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.",435.52,"1898283-02-7",{"v":87,"d":"87.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/ly3200882.html","C24H29N5O3","Free Base","N/A","CC(C)(O)C1=NC=CC(=C1)NC2=NC=CC(=C2)OC3=C[N](N=C3C4CCOCC4)C5CC5",3.363,5,1,7]
["S8777","Evobrutinib (M-2951)","e6","L3900-30","in 10mM DMSO","BTK","Protein Tyrosine Kinase","Evobrutinib (M-2951, MSC-2364447C) is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity.",429.51,"1415823-73-2",{"v":86,"d":"86.00"},200.23,"<1","N/A","http://www.selleckchem.com/products/evobrutinib.html","C25H27N5O2","Free Base","MSC-2364447C","NC1=C(C(=NC=N1)NCC2CCN(CC2)C(=O)C=C)C3=CC=C(OC4=CC=CC=C4)C=C3",3.916,4,2,7]
["S8780","AZD3229","f6","L3900-30","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","AZD3229 is a potent, pan-Kit (c-Kit) mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant Kit (c-Kit) driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).",479.51,"2248003-60-1",{"v":96,"d":"96.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://www.selleck.cn/products/azd3229.html","C24H26FN7O3","free base","N/A","COCCOC1=CC(=C2C(=NC=NC2=C1)NC3=CC=C(NC(=O)C[N]4C=C(N=N4)C(C)C)C=C3)F",3.766,7,2,10]
["S8788","CH7057288","g6","L3900-30","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.",569.67,"2095616-82-1",{"v":100,"d":"100.00"},175.54,"<1","N/A","http://www.selleck.cn/products/ch7057288.html","C32H31N3O5S","Free Base","N/A","CC1=CC(=CC(=N1)C#CC2=CC3=C(C=C2)C4=C(O3)C(C)(C)C5=CC(=CC=C5C4=O)N[S](C)(=O)=O)C(=O)NC(C)(C)C",5.151,6,2,6]
["S8791","Zanubrutinib (BGB-3111)","h6","L3900-30","in 10mM DMSO","BTK","Protein Tyrosine Kinase","Zanubrutinib (BGB-3111) is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR.",471.55,"1691249-45-2",{"v":94,"d":"94.00"},199.34,"<1","N/A","http://www.selleck.cn/products/zanubrutini-bgb-3111.html","C27H29N5O3","Free Base","N/A","NC(=O)C1=C2NCCC(C3CCN(CC3)C(=O)C=C)[N]2N=C1C4=CC=C(OC5=CC=CC=C5)C=C4",3.478,4,2,6]
["S8795","FDL169","a7","L3900-30","in 10mM DMSO","CFTR","Transmembrane Transporters","FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.",486.49,"1628416-28-3",{"v":33,"d":"33.00"},67.83,"<1","N/A","http://www.selleck.cn/products/fdl169.html","C27H23FN4O4","Free Base","N/A","CCOC1=CC=C2C(=C1)C(=O)N(CC(=O)N(C)C3=CC=C4N=C(C)OC4=C3)N=C2C5=CC(=CC=C5)F",{"v":3.87,"d":"3.870"},6,0,6]
["S8801","CC-90003","b7","L3900-30","in 10mM DMSO","ERK","MAPK","CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay.",458.44,"1621999-82-3",{"v":92,"d":"92.00"},200.68,"<1","N/A","http://www.selleckchem.com/products/cc-90003.html","C22H21F3N6O2","Free Base","N/A","COC1=CC(=C(C)C=N1)NC2=NC(=C(C=N2)C(F)(F)F)NC3=C(NC(=O)C=C)C=C(C)C=C3",5.316,5,3,8]
["S8804","Brepocitinib (PF-06700841)","c7","L3900-30","in 10mM DMSO","JAK","JAK/STAT","Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.",{"v":389.4,"d":"389.40"},"1883299-62-4",{"v":78,"d":"78.00"},200.31,"<1","N/A","http://www.selleck.cn/products/pf-06700841.html","C18H21F2N7O","Free Base","PF-841","C[N]1C=C(NC2=NC=CC(=N2)N3CC4CCC(C3)N4C(=O)C5CC5(F)F)C=N1",1.608,4,1,4]
["S8807","PFK158","d7","L3900-30","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.",328.29,"1462249-75-7",{"v":14,"d":"14.00"},42.65,"<1","N/A","http://www.selleck.cn/products/pfk158.html","C18H11F3N2O","free base","N/A","FC(F)(F)C1=CC=C2C=CC(=NC2=C1)\\C=C\\C(=O)C3=CC=NC=C3",4.108,3,0,4]
["S8817","Almonertinib (HS-10296)","e7","L3900-30","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Almonertinib (Aumolertinib, HS-10296, Ameile) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.",525.64,"1899921-05-1",{"v":100,"d":"100.00"},190.24,"<1","N/A","http://www.selleck.cn/products/hs-10296.html","C30H35N7O2","Free Base","Aumolertinib, Ameile","COC1=C(NC2=NC(=CC=N2)C3=C[N](C4CC4)C5=C3C=CC=C5)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",{"v":5.16,"d":"5.160"},4,2,11]
["S8821","GSK3179106","f7","L3900-30","in 10mM DMSO","c-RET","Apoptosis","GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET (c-RET) kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.",467.41,"1627856-64-7",{"v":93,"d":"93.00"},198.97,"<1","N/A","http://www.selleck.cn/products/gsk3179106.html","C22H21F4N3O4","Free Base","N/A","CCOC1=CC(=O)NC=C1C2=CC=C(CC(=O)NC3=NOC(=C3)C(C)(C)C(F)(F)F)C(=C2)F",3.357,5,2,8]
["S8823","ABX-1431","g7","L3900-30","in 10mM DMSO","Lipase","Metabolism","ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.",507.39,"1446817-84-0",{"v":100,"d":"100.00"},197.09,"<1","N/A","http://www.selleck.cn/products/abx-1431.html","C20H22F9N3O2","Free Base","N/A","FC(F)(F)C(OC(=O)N1CCN(CC1)CC2=C(C=C(C=C2)C(F)(F)F)N3CCCC3)C(F)(F)F",5.372,2,0,8]
["S8840","SEL120 (SEL120-34A) hydrochloride","h7","L3900-30","in 10mM DMSO","CDK","Cell Cycle","SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively.",{"v":450.6,"d":"450.60"},"1609452-30-3",{"v":11,"d":"11.00"},24.41,{"v":90,"d":"90.00"},199.73,"http://www.selleck.cn/products/sel120.html","C15H18Br2N4.xHCl","hydrochloride","SEL120-34","Cl.CC1=C2N=C(N3CCNCC3)[N]4CCCC(=C24)C(=C1Br)Br",4.572,1,1,1]
["S8842","BAY-218","a8","L3900-30","in 10mM DMSO","AhR","Metabolism","BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.",401.82,"2162982-11-6",{"v":80,"d":"80.00"},199.09,"<1","N/A","http://www.selleck.cn/products/bay-218.html","C20H17ClFN3O3","free base","N/A","CC(CO)NC(=O)C1=CC(=NN(C2=CC=CC(=C2)F)C1=O)C3=CC=C(Cl)C=C3",3.106,3,2,5]
["S8854","JNJ-38877618(OMO-1)","b8","L3900-30","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).",374.35,"943540-74-7",{"v":10,"d":"10.00"},26.71,"<1","N/A","http://www.selleck.cn/products/jnj-38877618.html","C20H12F2N6","free base","N/A","FC(F)(C1=CC2=C(C=C1)N=CC=C2)C3=NN=C4C=CC(=N[N]34)C5=CC=NC=C5",3.252,5,0,3]
["S8867","Bentamapimod (AS602801)","c8","L3900-30","in 10mM DMSO","JNK","MAPK","Bentamapimod (AS602801) is a novel, orally active JNK inhibitor with IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively.",457.55,"848344-36-5",{"v":24,"d":"24.00"},52.45,"<1","N/A","http://www.selleck.cn/products/bentamapimod.html","C25H23N5O2S","free base","N/A","N#CC(C1=NC2=CC=CC=C2S1)C3=NC(=NC=C3)OCC4=CC=C(CN5CCOCC5)C=C4",4.228,5,0,7]
["S8871","Omadacycline tosylate","d8","L3900-30","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Omadacycline tosylate(PTK 0796 tosylate,Amadacycline tosylate) is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria.",728.85,"1075240-43-5",{"v":100,"d":"100.00"},{"v":137.2,"d":"137.20"},{"v":100,"d":"100.00"},{"v":137.2,"d":"137.20"},"http://www.selleck.cn/products/omadacycline-tosylate.html","C36H48N4O10S","tosylate","PTK 0796 tosylate,Amadacycline tosylate","CN(C)C1C2CC3CC4=C(C=C(CNCC(C)(C)C)C(=C4C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O)O)N(C)C.CC5=CC=C(C=C5)[S](O)(=O)=O",2.749,3,5,8]
["S8873","Letermovir (AIC246)","e8","L3900-30","in 10mM DMSO","CMV","Microbiology","Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.",572.55,"917389-32-3",{"v":100,"d":"100.00"},174.66,"<1","N/A","http://www.selleck.cn/products/letermovir.html","C29H28F4N4O4","free base","MK-8228","COC1=CC(=CC=C1)N2CCN(CC2)C3=NC4=C(C=CC=C4F)C(CC(O)=O)N3C5=CC(=CC=C5OC)C(F)(F)F",5.451,4,0,8]
["S9001","Malic acid","f8","L3900-30","in 10mM DMSO","Others","Others","Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits.",134.09,"6915-15-7",{"v":27,"d":"27.00"},201.36,"N/A","N/A","https://www.selleckchem.com/products/malic-acid.html","C4H6O5","free base","Hydroxybutanedioic acid, 2-Hydroxysuccinic acid","OC(CC(O)=O)C(O)=O",-1.012,2,1,3]
["S9002","L-Fucose","g8","L3900-30","in 10mM DMSO","Others","Others","Fucose (6-Deoxy-L-Galactose, L-fucopyranose) is found on N-linked glycans on the mammalian, insect and plant cell surface. L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements.",164.16,"2438-80-4",{"v":33,"d":"33.00"},201.03,"N/A","N/A","https://www.selleckchem.com/products/l-fucose.html","C6H12O5","free base","6-Deoxy-L-Galactose, L-fucopyranose","CC(O)C(O)C(O)C(O)C=O",-1.903,1,4,4]
["S9007","2'-deoxyguanosine","h8","L3900-30","in 10mM DMSO","Others","Others","2'-deoxyguanosine is a kind of purine nucleoside.",267.24,"961-07-9",{"v":53,"d":"53.00"},198.32,"N/A","N/A","https://www.selleckchem.com/products/2-deoxyguanosine-monohydrate.html","C10H13N5O4","free base","2'-Deoxy-D-guanosine","NC1=NC2=C(N=C[N]2C3CC(O)C(CO)O3)C(=O)N1",-1.613,4,4,2]
["S9010","Bevirimat","a9","L3900-30","in 10mM DMSO","HIV Protease","Microbiology","Bevirimat (MPC-4326, PA-457, YK-FH312), the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients.",584.83,"174022-42-5",{"v":10,"d":"10.00"},{"v":17.1,"d":"17.10"},"N/A","N/A","https://www.selleckchem.com/products/bevirimat.html","C36H56O6","free base","MPC-4326, PA-457, YK-FH312","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(OC(=O)CC(C)(C)C(O)=O)C(C)(C)C5CCC34C)C12)C(O)=O",{"v":7.65,"d":"7.650"},4,0,7]
["S9046","Berberine","b9","L3900-30","in 10mM DMSO","Bacterial","Microbiology","Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.",336.36,"2086-83-1",{"v":45,"d":"45.00"},133.78,"N/A","N/A","https://www.selleckchem.com/products/berberine.html","C20H18NO4","free base","Umbellatine","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4",3.962,4,0,2]
["S9055","Salvianolic acid A","c9","L3900-30","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.",494.45,"96574-01-5",{"v":10,"d":"10.00"},20.22,"N/A","N/A","https://www.selleckchem.com/products/salvianolic-acid-a.html","C26H22O10","free base","Dan Phenolic Acid A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)\\C=C\\C2=C(/C=C/C3=CC(=C(O)C=C3)O)C(=C(O)C=C2)O",4.209,3,6,9]
["S9063","Harringtonine","d9","L3900-30","in 10mM DMSO","Antiviral","Microbiology","Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.",531.59,"26833-85-2",{"v":10,"d":"10.00"},18.81,"N/A","N/A","https://www.selleckchem.com/products/harringtonine.html","C28H37NO9","free base","FH15975","COC(=O)CC(O)(CCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",1.961,7,0,10]
["S9080","Anhydroicaritin","e9","L3900-30","in 10mM DMSO","Others","Apoptosis","Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.",368.38,"118525-40-9",{"v":10,"d":"10.00"},27.15,"N/A","N/A","https://www.selleckchem.com/products/anhydroicaritin.html","C21H20O6","free base","Cycloicaritin","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C(=C3O2)CC=C(C)C",3.954,3,3,4]
["S9089","Magnoflorine","f9","L3900-30","in 10mM DMSO","Tyrosinase","Proteases","Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.",342.41,"2141-09-5",{"v":10,"d":"10.00"},{"v":29.2,"d":"29.20"},"N/A","N/A","https://www.selleckchem.com/products/magnoflorine.html","C20H24NO4","free base","Escholin, Thalictrin","COC1=C(O)C2=C(CC3C4=C2C(=C(OC)C=C4CC[N+]3(C)C)O)C=C1",1.728,2,2,2]
["S9101","Ingenol","g9","L3900-30","in 10mM DMSO","PKC","Cytoskeletal Signaling","Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.",348.43,"30220-46-3",{"v":69,"d":"69.00"},198.03,"N/A","N/A","https://www.selleckchem.com/products/ingenol.html","C20H28O5","free base","N/A","CC1CC2C(C3C=C(CO)C(O)C4(O)C(O)C(=CC14C3=O)C)C2(C)C",0.543,1,3,1]
["S9133","Chicoric acid","h9","L3900-30","in 10mM DMSO","Others","Others","Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects.",474.37,"70831-56-0",{"v":94,"d":"94.00"},198.16,"N/A","N/A","https://www.selleckchem.com/products/chicoric-acid.html","C22H18O12","free base","Dicaffeoyltartaric acid","OC(=O)C(OC(=O)\\C=C\\C1=CC(=C(O)C=C1)O)C(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C(O)=O",{"v":2.39,"d":"2.390"},6,4,11]
["S9143","Ammonium Glycyrrhizate","a10","L3900-30","in 10mM DMSO","Others","Others","Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products.",839.96,"53956-04-0",{"v":100,"d":"100.00"},119.05,"N/A","N/A","https://www.selleckchem.com/products/ammonium-glycyrrhizate.html","C42H65NO16","free base","Glycamil, Glycyrram","N.CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",-0.915,8,5,7]
["S9151","Praeruptorin E","b10","L3900-30","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.",428.47,"78478-28-1",{"v":34.6,"d":"34.60"},80.75,"N/A","N/A","https://www.selleckchem.com/products/praeruptorin-e.html","C24H28O7","free base","N/A","C\\C=C(C)/C(=O)OC1C(OC(=O)CC(C)C)C2=C3OC(=O)C=CC3=CC=C2OC1(C)C",4.877,7,0,7]
["S9172","Phellodendrine","c10","L3900-30","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.",342.41,"6873-13-8",{"v":42.6,"d":"42.60"},124.41,"N/A","N/A","https://www.selleckchem.com/products/phellodendrine.html","C20H24NO4","free base","N/A","COC1=C(O)C=C2C3CC4=C(C[N+]3(C)CCC2=C1)C=C(OC)C(=C4)O",1.793,2,2,2]
["S9186","Liensinine perchlorate","d10","L3900-30","in 10mM DMSO","Others","Others","Liensinine is the active constituent of plumula nelambinis with anti-hypertension.",{"v":711.2,"d":"711.20"},"2385-63-9",{"v":100,"d":"100.00"},140.61,"N/A","N/A","https://www.selleckchem.com/products/liensinine-perchlorate.html","C37H43ClN2O10","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2.O[Cl](=O)(=O)=O",7.345,4,2,9]
["S9188","Magnoflorine chloride","e10","L3900-30","in 10mM DMSO","Others","Others","Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities.",377.86,"6681-18-1",{"v":76,"d":"76.00"},201.13,"N/A","N/A","https://www.selleckchem.com/products/magnoflorinechloride.html","C20H24ClNO4","free base","Escholine chloride, Thalictrine chloride, Corytuberine methochloride","[Cl-].COC1=C(O)C2=C(CC3C4=C2C(=C(OC)C=C4CC[N+]3(C)C)O)C=C1",-0.946,2,2,2]
["S9245","Phellodendrine chloride","f10","L3900-30","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities.",377.86,"104112-82-5",{"v":36,"d":"36.00"},95.27,"N/A","N/A","https://www.selleckchem.com/products/phellodendrine-chloride.html","C20H24ClNO4","free base","N/A","[Cl-].COC1=CC2=C(CC3C4=C(CC[N+]3(C)C2)C=C(OC)C(=C4)O)C=C1O",-0.881,2,2,2]
["S9295","Dauricine","g10","L3900-30","in 10mM DMSO","NF-κB","NF-κB","Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells.",624.77,"524-17-4",{"v":100,"d":"100.00"},160.06,"N/A","N/A","https://www.selleckchem.com/products/dauricine.html","C38H44N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(OC4=C(O)C=CC(=C4)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C=C3)N(C)CC2",7.245,5,1,10]
["S9321","Topotecan","h10","L3900-30","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.",421.45,"123948-87-8",{"v":84,"d":"84.00"},199.31,"N/A","N/A","https://www.selleckchem.com/products/topotecan.html","C23H23N3O5","free base","NSC609699,Nogitecan,SKFS 104864A","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.577,4,1,3]
["S9326","Scopolamine","a11","L3900-30","in 10mM DMSO","AChR","Neuronal Signaling","Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.",303.35,"51-34-3","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/scopolamine.html","C17H21NO4","free base","Skopolamin","CN1C2CC(CC1C3OC23)OC(=O)C(CO)C4=CC=CC=C4",0.823,3,1,5]
["S9327","Carboprost","b11","L3900-30","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Carboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties.",368.51,"35700-23-3",{"v":73,"d":"73.00"},{"v":198.1,"d":"198.10"},{"v":-1,"d":"-1.00"},-2.71,"https://www.selleckchem.com/products/carboprost.html","C21H36O5","free base","N/A","CCCCCC(C)(O)/C=C/C1C(O)CC(O)C1C\\C=C/CCCC(O)=O",3.188,1,2,12]
["S9329","Orcinol","c11","L3900-30","in 10mM DMSO","Others","Others","Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects.",124.14,"504-15-4",{"v":24,"d":"24.00"},193.33,"N/A","N/A","https://www.selleckchem.com/products/orcinol.html","C7H8O2","free base","5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene","CC1=CC(=CC(=C1)O)O",1.832,0,2,0]
["S9339","S-(-)-Cotinine","d11","L3900-30","in 10mM DMSO","Others","Others","S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.,",176.22,"486-56-6","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/s-cotinine.html","C10H12N2O","free base","N/A","CN1C(CCC1=O)C2=CN=CC=C2",0.296,2,0,1]
["S9348","D-(+)-Trehalose Anhydrous","e11","L3900-30","in 10mM DMSO","Others","Others","Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.",{"v":342.3,"d":"342.30"},"99-20-7",{"v":68,"d":"68.00"},198.66,"N/A","N/A","https://www.selleckchem.com/products/d-trehalose-anhydrous.html","C12H22O11","free base","N/A","OCC1OC(OC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O",-4.261,3,8,4]
["S9354","Oxalic acid","f11","L3900-30","in 10mM DMSO","Others","Others","Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.",90.03,"144-62-7",{"v":18,"d":"18.00"},199.92,"N/A","N/A","https://www.selleckchem.com/products/oxalic-acid.html","C2H2O4","free base","Ethanedioic acid, Wood bleach","OC(=O)C(O)=O",-0.429,2,0,1]
["S9366","5'-Adenylic acid","g11","L3900-30","in 10mM DMSO","Others","Others","AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.",347.22,"61-19-8",{"v":34.9,"d":"34.90"},100.51,"N/A","N/A","https://www.selleckchem.com/products/5-adenylic-acid.html","C10H14N5O7P","free base","AMP, Adenosine monophosphate","NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O",-1.952,5,3,4]
["S9368","ADP","h11","L3900-30","in 10mM DMSO","Others","Others","ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.",{"v":427.2,"d":"427.20"},"58-64-0",{"v":6,"d":"6.00"},14.04,"N/A","N/A","https://www.selleckchem.com/products/adp.html","C10H15N5O10P2","free base","Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate","NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(=O)O[P](O)(O)=O)C(O)C3O",-2.239,6,3,6]
["S9393","(4S)-4-Hydroxy-L-isoleucine","a2","L3900-31","in 10mM DMSO","Others","Metabolism","(4S)-4-hydroxy-L-isoleucine is an L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent. It has a role as a plant metabolite.",147.17,"55399-93-4",{"v":2,"d":"2.00"},13.59,"N/A","N/A","https://www.selleckchem.com/products/4s-4-hydroxy-l-isoleucine.html","C6H13NO3","free base","N/A","CC(O)C(C)C(N)C(O)=O",-3.161,1,2,3]
["S9411","Liensinine","b2","L3900-31","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"2586-96-1",{"v":100,"d":"100.00"},163.74,"N/A","N/A","https://www.selleckchem.com/products/liensinine.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9424","Liensinine diperchlorate","c2","L3900-31","in 10mM DMSO","Autophagy,Mitophagy","Autophagy","Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.",811.66,"5088-90-4",{"v":50,"d":"50.00"},{"v":61.6,"d":"61.60"},"N/A","N/A","https://www.selleckchem.com/products/liensinine-diperchlorate.html","C37H44Cl2N2O14","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC(=C(O)C=C3)OC4=C(OC)C=C5CCN(C)C(CC6=CC=C(O)C=C6)C5=C4)N(C)CC2.O[Cl](=O)(=O)=O.O[Cl](=O)(=O)=O",7.669,4,2,9]
["S9449","Urocanic acid","d2","L3900-31","in 10mM DMSO","Others","Others","Urocanic acid is an intermediate in the catabolism of L-histidine.",138.12,"104-98-3",{"v":28,"d":"28.00"},202.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/urocanic-acid.html","C6H6N2O2","Free Base","N/A","OC(=O)/C=C/C1=C[NH]C=N1",0.243,2,1,2]
["S9454","Undecanoic acid","e2","L3900-31","in 10mM DMSO","Others","Others","Undecanoic acid (Undecylic acid) is a medium chain length monocarboxylic acid that appears to be involved in the control of triacylglycerol synthesis.",186.29,"112-37-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/undecanoic-acid.html","C11H22O2","Free Base","Undecylic acid","CCCCCCCCCCC(O)=O",4.111,1,0,9]
["S9459","Mecamylamine Hydrochloride","f2","L3900-31","in 10mM DMSO","AChR","Neuronal Signaling","Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.",203.75,"826-39-1",{"v":41,"d":"41.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","N/A","C11H21N · HCl","Hydrochloride","N/A","Cl.CNC1(C)C2CCC(C2)C1(C)C",2.565,0,1,1]
["S9460","Ethotoin","g2","L3900-31","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ethotoin (Peganone) is an orally active anticonvulsant agent used in epilepsy research. Ethotoin inhibits nerve impulses in the motor cortex by lowering sodium ion influx, limiting tetanic stimulation.",204.23,"86-35-1",{"v":41,"d":"41.00"},200.75,{"v":-1,"d":"-1.00"},"N/A","N/A","C11H12N2O2","Free Base","N/A","CCN1C(=O)NC(C1=O)C2=CC=CC=C2",1.113,2,1,2]
["S9461","Benzonatate","h2","L3900-31","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Benzonatate(Benzononatine)  has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite.",603.74,"32760-16-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/benzonatate.html","(C2H4O)nC12H17NO2","Free Base","Benzononatine","CCCCNC1=CC=C(C=C1)C(=O)OCCOC",3.426,3,1,9]
["S9463","Demecarium Bromide","a3","L3900-31","in 10mM DMSO","AChR","Neuronal Signaling","Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent.",716.59,"56-94-0",{"v":100,"d":"100.00"},139.55,{"v":-1,"d":"-1.00"},"N/A","N/A","C32H52Br2N4O4","Bromide","N/A","[Br-].[Br-].CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C",-0.615,4,0,17]
["S9466","Methenamine Hippurate","b3","L3900-31","in 10mM DMSO","Bacterial","Microbiology","Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.",319.36,"5714-73-8",{"v":14,"d":"14.00"},43.84,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/methenamine-hippurate.html","C15H21N5O3","Hippurate","N/A","OC(=O)CNC(=O)C1=CC=CC=C1.C2N3CN4CN2CN(C3)C4",{"v":-2.43,"d":"-2.430"},2,1,3]
["S9469","Haloperidol Decanoate","c3","L3900-31","in 10mM DMSO","D2R","Neuronal Signaling","Haloperidol Decanoate is an antipsychotic drug used for the management of schizophrenia. It has antagonistic effects on dopamine 2 receptor.",530.11,"74050-97-8",{"v":100,"d":"100.00"},188.64,{"v":-1,"d":"-1.00"},"N/A","N/A","C31H41ClFNO3","Decanoate","N/A","CCCCCCCCCC(=O)OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Cl)C=C3",8.127,3,0,16]
["S9500","Valbenazine tosylate","d3","L3900-31","in 10mM DMSO","VMAT","Transmembrane Transporters","Valbenazine tosylate (NBI-98854) is the tosylate salt of valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).",762.97,"1639208-54-0",{"v":100,"d":"100.00"},131.07,{"v":-1,"d":"-1.00"},-1.31,"https://www.selleckchem.com/products/valbenazine-tosylate.html","C38H54N2O10S2","free base","NBI-98854","COC1=C(OC)C=C2C3CC(OC(=O)C(N)C(C)C)C(CC(C)C)CN3CCC2=C1.CC4=CC=C(C=C4)[S](O)(=O)=O.CC5=CC=C(C=C5)[S](O)(=O)=O",7.062,4,1,10]
["S9502","Madecassic acid","e3","L3900-31","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.",{"v":504.7,"d":"504.70"},"18449-41-7",{"v":100,"d":"100.00"},198.13,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/madecassic-acid.html","C30H48O6","Free Base","Brahmic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(O)=O",3.265,1,4,2]
["S9507","(−)-Norepinephrine","f3","L3900-31","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.",169.18,"51-41-2",{"v":11,"d":"11.00"},65.02,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/norepinephrine.html","C8H11NO3","Free Base","Arterenol, Levarterenol, L-Noradrenaline","NCC(O)C1=CC(=C(O)C=C1)O",-0.059,0,4,2]
["S9508","Brimonidine","g3","L3900-31","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.",292.13,"59803-98-4",{"v":26,"d":"26.00"},{"v":89,"d":"89.00"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/brimonidine.html","C11H10BrN5","Free Base","Bromoxidine, UK 14304","BrC1=C(NC2=NCCN2)C=CC3=C1N=CC=N3",1.237,3,2,2]
["S9509","Tiapride Hydrochloride","h3","L3900-31","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.",364.89,"51012-33-0",{"v":35,"d":"35.00"},95.92,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tiapride-hydrochloride.html","C15H25ClN2O4S","hydrochloride","N/A","Cl.CCN(CC)CCNC(=O)C1=CC(=CC=C1OC)[S](C)(=O)=O",1.766,4,1,8]
["S9510","Protriptyline hydrochloride","a4","L3900-31","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake.",299.84,"1225-55-4",{"v":60,"d":"60.00"},200.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/protriptyline-hydrochloride.html","C19H22ClN","hydrochloride","N/A","Cl.CNCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",4.423,0,1,4]
["S9566","Bepridil hydrochloride","b4","L3900-31","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Bepridil hydrochloride(CERM 1978) is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.",421.02,"74764-40-2",{"v":41,"d":"41.00"},97.38,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bepridil-hydrochloride.html","C24H37ClN2O2","hydrochloride","CERM 1978","O.Cl.CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3",5.439,1,0,10]
["S9567","Indinavir Sulfate","c4","L3900-31","in 10mM DMSO","COVID-19,HIV Protease","Microbiology","Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.",711.87,"157810-81-6",{"v":100,"d":"100.00"},140.48,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/indinavir-sulfate.html","C36H49N5O8S","Sulfate","Crixivan, L-735524, MK-639","CC(C)(C)NC(=O)C1CN(CCN1CC(O)CC(CC2=CC=CC=C2)C(=O)NC3C(O)CC4=C3C=CC=C4)CC5=CN=CC=C5.O[S](O)(=O)=O",2.475,3,4,12]
["S9568","Sapropterin Dihydrochloride","d4","L3900-31","in 10mM DMSO","Hydroxylase","Metabolism","Sapropterin Dihydrochloride (Tetrahydrobiopterin, R-THBP), a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.",314.17,"69056-38-8",{"v":63,"d":"63.00"},200.53,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/sapropterin-dihydrochloride.html","C9H17Cl2N5O3","Dihydrochloride","Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride","Cl.Cl.CC(O)C(O)C1CNC2=C(N1)C(=O)NC(=N2)N",-1.572,2,6,2]
["S2933","AM580","e4","L3900-31","in 10mM DMSO","Retinoid Receptor","Metabolism","AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.",351.44,"102121-60-8",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://www.selleck.cn/products/am580.html","C22H25NO3","Free Base","N/A","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S2934","Ensartinib (X-396) dihydrochloride","f4","L3900-31","in 10mM DMSO","ALK","Angiogenesis","Ensartinib (X-396) is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.",634.36,"2137030-98-7",{"v":100,"d":"100.00"},157.64,{"v":27,"d":"27.00"},42.56,"http://www.selleck.cn/products/ensartinib-dihydrochloride.html","C26H29Cl4FN6O3","Dihydrochloride","N/A","Cl.Cl.CC1CN(CC(C)N1)C(=O)C2=CC=C(NC(=O)C3=NN=C(N)C(=C3)OC(C)C4=C(Cl)C(=CC=C4Cl)F)C=C2",5.051,5,3,6]
["S6490","Vadadustat","g4","L3900-31","in 10mM DMSO","HIF","Angiogenesis","Vadadustat (AKB-6548, B-506, PG-1016548) is a novel, titratable, oral HIF-PH inhibitor.",{"v":306.7,"d":"306.70"},"1000025-07-9",{"v":61,"d":"61.00"},198.89,"<1","N/A","http://www.selleck.cn/products/vadadustat.html","C14H11ClN2O4","Free Base","AKB-6548, B-506, PG-1016548","OC(=O)CNC(=O)C1=NC=C(C=C1O)C2=CC=CC(=C2)Cl",1.738,3,2,4]
["S6531","Bohemine","h4","L3900-31","in 10mM DMSO","CDK","Cell Cycle","Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.",340.42,"189232-42-6",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://www.selleck.cn/products/bohemine.html","C18H24N6O","Free Base","N/A","CC(C)[N]1C=NC2=C1N=C(NCCCO)N=C2NCC3=CC=CC=C3",2.482,3,3,8]
["S6539","ASP5878","a5","L3900-31","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.",407.37,"1453208-66-6",{"v":81,"d":"81.00"},198.84,"<1","N/A","http://www.selleck.cn/products/asp5878.html","C18H19F2N5O4","Free Base","N/A","COC1=C(F)C(=C(F)C(=C1)OC)COC2=CN=C(NC3=C[N](CCO)N=C3)N=C2",2.178,6,2,9]
["S6546","PD153035","b5","L3900-31","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM).",360.21,"153436-54-5",{"v":6,"d":"6.00"},16.66,"<1","N/A","http://www.selleck.cn/products/pd153035.html","C16H14BrN3O2","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=NC=N2)NC3=CC(=CC=C3)Br",4.193,4,1,4]
["S6551","Adelmidrol","c5","L3900-31","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.",274.36,"1675-66-7",{"v":55,"d":"55.00"},200.47,{"v":55,"d":"55.00"},200.47,"http://www.selleck.cn/products/adelmidrol.html","C13H26N2O4","Free Base","N/A","OCCNC(=O)CCCCCCCC(=O)NCCO",-0.001,2,4,12]
["S6558","Irosustat (BN83495)","d5","L3900-31","in 10mM DMSO","Others","Metabolism","Irosustat (STX64, BN83495), a tricyclic coumarin sulfamate, is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor with an IC50 of 8 nM.",309.34,"288628-05-7",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://www.selleck.cn/products/irosustat.html","C14H15NO5S","Free Base","STX64","N[S](=O)(=O)OC1=CC=C2C3=C(CCCCC3)C(=O)OC2=C1",2.527,3,1,2]
["S6581","Fosamprenavir calcium salt","e5","L3900-31","in 10mM DMSO","HIV Protease","Microbiology","Fosamprenavir(GW433908G) is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections.",623.67,"226700-81-8",{"v":100,"d":"100.00"},160.34,"<1","N/A","http://www.selleck.cn/products/fosamprenavir-calcium-salt.html","C25H34CaN3O9PS","Calcium salt","GW433908G","[Ca++].CC(C)CN(CC(O[P]([O-])([O-])=O)C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)[S](=O)(=O)C3=CC=C(N)C=C3",{"v":0.18,"d":"0.180"},6,2,14]
["S6582","Ozenoxacin","f5","L3900-31","in 10mM DMSO","Antibiotics","Microbiology","Ozenoxacin(T-3912) is a quinolone antibiotic used for the treatment of impetigo.",363.41,"245765-41-7",{"v":5,"d":"5.00"},13.76,"<1","N/A","http://www.selleck.cn/products/ozenoxacin.html","C21H21N3O3","Free Base","T-3912","CNC1=NC=C(C=C1C)C2=C(C)C3=C(C=C2)C(=O)C(=CN3C4CC4)C(O)=O",3.334,3,1,4]
["S6595","THZ531","g5","L3900-31","in 10mM DMSO","CDK","Cell Cycle","THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively.",558.07,"1702809-17-3",{"v":100,"d":"100.00"},179.19,"<1","N/A","http://www.selleck.cn/products/thz531.html","C30H32ClN7O2","Free Base","N/A","CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)N2CCCC(C2)NC3=NC(=C(Cl)C=N3)C4=C[NH]C5=C4C=CC=C5",4.645,4,3,8]
["S6616","ETC-159","h5","L3900-31","in 10mM DMSO","PORCN","Stem Cells & Wnt","ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.",391.38,"1638250-96-0",{"v":78,"d":"78.00"},199.29,"<1","N/A","http://www.selleck.cn/products/etc-159.html","C19H17N7O3","Free Base","ETC-1922159","CN1C(=O)N(C)C2=C([N](CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4)C=N2)C1=O",1.404,6,1,4]
["S6617","MSX-122","a6","L3900-31","in 10mM DMSO","CXCR","Immunology & Inflammation","MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).",292.34,"897657-95-3",{"v":3,"d":"3.00"},10.26,"<1","N/A","http://www.selleck.cn/products/msx-122.html","C16H16N6","Free Base","Q-122","C(NC1=NC=CC=N1)C2=CC=C(CNC3=NC=CC=N3)C=C2",2.099,4,2,6]
["S6619","ABT 702 dihydrochloride","b6","L3900-31","in 10mM DMSO","Adenosine Kinase","Neuronal Signaling","ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation.",536.25,"1188890-28-9",{"v":100,"d":"100.00"},186.48,"<1","N/A","http://www.selleck.cn/products/abt-702-dihydrochloride.html","C22H21BrCl2N6O","Dihydrochloride","N/A","Cl.Cl.NC1=C2C(=NC=N1)N=C(C=C2C3=CC(=CC=C3)Br)C4=CN=C(C=C4)N5CCOCC5",4.441,5,1,3]
["S6620","Danirixin (GSK1325756)","c6","L3900-31","in 10mM DMSO","CXCR,Interleukins","Immunology & Inflammation","Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 (IL-8) binding = 12.5 nM), selective, and reversible CXCR2 antagonist.",{"v":441.9,"d":"441.90"},"954126-98-8",{"v":88,"d":"88.00"},199.14,"<1","N/A","http://www.selleck.cn/products/danirixin.html","C19H21ClFN3O4S","Free Base","N/A","CC1=C(NC(=O)NC2=C(O)C(=C(Cl)C=C2)[S](=O)(=O)C3CCCNC3)C=CC=C1F",3.255,3,4,4]
["S6624","Avatrombopag","d6","L3900-31","in 10mM DMSO","TpoR","Immunology & Inflammation","Avatrombopag (AKR-501,E5501,YM477) is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.",649.65,"570406-98-3",{"v":20,"d":"20.00"},30.79,"<1","N/A","http://www.selleck.cn/products/avatrombopag.html","C29H34Cl2N6O3S2","Free Base","AKR-501,E5501,YM477","OC(=O)C1CCN(CC1)C2=C(Cl)C=C(C=N2)C(=O)NC3=NC(=C(S3)N4CCN(CC4)C5CCCCC5)C6=CC(=CS6)Cl",3.561,4,1,7]
["S6625","Temsavir (BMS-626529)","e6","L3900-31","in 10mM DMSO","HIV Protease","Microbiology","Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.",473.48,"701213-36-7",{"v":95,"d":"95.00"},200.64,"<1","N/A","http://www.selleck.cn/products/temsavir-bms-626529.html","C24H23N7O4","Free Base","N/A","COC1=CN=C([N]2C=NC(=N2)C)C3=C1C(=C[NH]3)C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5",1.174,7,1,5]
["S6626","Brequinar (DUP785)","f6","L3900-31","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.",375.37,"96187-53-0",{"v":37,"d":"37.00"},98.57,"<1","N/A","http://www.selleck.cn/products/brequinar.html","C23H15F2NO2","Free Base","NSC 368390","CC1=C(N=C2C=CC(=CC2=C1C(O)=O)F)C3=CC=C(C=C3)C4=C(F)C=CC=C4",6.008,2,0,3]
["S6627","E-4031 dihydrochloride","g6","L3900-31","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type.",474.44,"113559-13-0",{"v":30,"d":"30.00"},63.23,{"v":48,"d":"48.00"},101.17,"http://www.selleck.cn/products/e-4031-dihydrochloride.html","C21H29Cl2N3O3S","Dihydrochloride","N/A","Cl.Cl.CC1=CC=CC(=N1)CCN2CCC(CC2)C(=O)C3=CC=C(N[S](C)(=O)=O)C=C3",{"v":3.05,"d":"3.050"},4,1,7]
["S6628","E7820","h6","L3900-31","in 10mM DMSO","Others","Angiogenesis","E7820 is a unique angiogenesis inhibitor with antitumor activities.",336.37,"289483-69-8",{"v":67,"d":"67.00"},199.19,"<1","N/A","http://www.selleck.cn/products/e7820.html","C17H12N4O2S","Free Base","N/A","CC1=C2C(=C(N[S](=O)(=O)C3=CC(=CC=C3)C#N)C=C1)[NH]C=C2C#N",2.855,2,2,3]
["S6631","Belotecan (CKD-602) hydrochloride","a7","L3900-31","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.",469.96,"213819-48-8",{"v":47,"d":"47.00"},100.01,{"v":4,"d":"4.00"},8.51,"http://www.selleck.cn/products/belotecan-ckd-602-hydrochloride.html","C25H28ClN3O4","Hydrochloride","N/A","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=CC5=C4CCNC(C)C)C2=O",2.713,4,1,5]
["S6633","AM 095","b7","L3900-31","in 10mM DMSO","LPA Receptor","GPCR & G Protein","AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.",456.49,"1228690-36-5",{"v":91,"d":"91.00"},199.35,"<1","N/A","http://www.selleck.cn/products/am-095.html","C27H24N2O5","Free Base","N/A","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(C=C2)C3=CC=C(CC(O)=O)C=C3)C4=CC=CC=C4",5.284,5,1,8]
["S6638","AMG-333","c7","L3900-31","in 10mM DMSO","TRP Channel","Transmembrane Transporters","AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.",453.32,"1416799-28-4",{"v":91,"d":"91.00"},200.74,"<1","N/A","http://www.selleck.cn/products/amg-333.html","C20H12F5N3O4","Free Base","N/A","OC(=O)C1=CN=C(C=C1)C(=O)NC(C2=CC(=C(OC(F)(F)F)C=C2)F)C3=C(F)C=CC=N3",4.843,5,1,7]
["S6644","Radiprodil (RGH-896)","d7","L3900-31","in 10mM DMSO","NMDAR","Neuronal Signaling","Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.",{"v":397.4,"d":"397.40"},"496054-87-6",{"v":79,"d":"79.00"},198.79,"<1","N/A","http://www.selleck.cn/products/radiprodil.html","C21H20FN3O4","Free Base","N/A","FC1=CC=C(CC2CCN(CC2)C(=O)C(=O)NC3=CC4=C(NC(=O)O4)C=C3)C=C1",2.883,4,2,4]
["S6645","AZD5069","e7","L3900-31","in 10mM DMSO","CXCR","Immunology & Inflammation","AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.",476.52,"878385-84-3",{"v":95,"d":"95.00"},199.36,"<1","N/A","http://www.selleck.cn/products/azd-5069.html","C18H22F2N4O5S2","Free Base","N/A","CC(OC1=NC(=NC(=C1)N[S](=O)(=O)N2CCC2)SCC3=C(F)C(=CC=C3)F)C(O)CO",{"v":1.88,"d":"1.880"},5,3,10]
["S6646","Ciforadenant (CPI-444)","f7","L3900-31","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.",407.43,"1202402-40-1",{"v":81,"d":"81.00"},198.81,"<1","N/A","http://www.selleck.cn/products/cpi-444.html","C20H21N7O3","Free Base","V81444","CC1=CC=C(O1)C2=C3N=N[N](CC4=NC(=CC=C4)COC5CCOC5)C3=NC(=N2)N",1.769,8,1,6]
["S6648","PF-06282999","g7","L3900-31","in 10mM DMSO","Peroxidases","Metabolism","PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.",325.77,"1435467-37-0",{"v":65,"d":"65.00"},199.53,"<1","N/A","http://www.selleck.cn/products/pf-06282999.html","C13H12ClN3O3S","Free Base","N/A","COC1=C(C=C(Cl)C=C1)C2=CC(=O)NC(=S)N2CC(N)=O",1.868,3,2,4]
["S6712","S107","h7","L3900-31","in 10mM DMSO","Others","Others","S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1.",209.31,"927871-76-9",{"v":42,"d":"42.00"},200.66,"<1","N/A","http://www.selleck.cn/products/s107.html","C11H15NOS","Free Base","N/A","COC1=CC=C2SCCN(C)CC2=C1",2.247,1,0,1]
["S6713","ITD-1","a8","L3900-31","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I (TGFBR1) or type II (TGFBR2) TGFβ receptors but potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A.",415.52,"1099644-42-4",{"v":83,"d":"83.00"},199.75,"<1","N/A","http://www.selleck.cn/products/itd-1.html","C27H29NO3","Free Base","N/A","CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C)(C)C2",4.434,3,1,5]
["S6715","YHO-13177","b8","L3900-31","in 10mM DMSO","BCRP","Transmembrane Transporters","YHO-13177, a novel acrylonitrile derivative, is a potent BCRP/ABCG2 inhibitor.",370.47,"912287-56-0",{"v":74,"d":"74.00"},199.75,"<1","N/A","http://www.selleck.cn/products/yho-13177.html","C20H22N2O3S","Free Base","N/A","COC1=C(OC)C=C(C=C1)/C(=C/C2=CC=C(S2)N3CCC(O)CC3)C#N",3.295,2,1,5]
["S6718","MKT-077","c8","L3900-31","in 10mM DMSO","Dyes","Others","MKT-077 (FJ-776) is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems.",{"v":432,"d":"432.00"},"147366-41-4",{"v":13,"d":"13.00"},30.09,{"v":86,"d":"86.00"},199.07,"http://www.selleck.cn/products/mkt-077.html","C21H22ClN3OS2","Free Base","FJ-776","[Cl-].CCN\\1C(=O)\\C(SC1=C\\C2=CC=CC=[N+]2CC)=C3/SC4=CC=CC=C4N3C",2.489,1,0,3]
["S6723","Darovasertib (LXS-196)","d8","L3900-31","in 10mM DMSO","PKC","Cytoskeletal Signaling","Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC).",472.47,"1874276-76-2",{"v":22,"d":"22.00"},46.56,"<1","N/A","http://www.selleck.cn/products/lxs-196.html","C22H23F3N8O","Free Base","IDE-196","CC1(N)CCN(CC1)C2=CC=CN=C2NC(=O)C3=NC(=CN=C3N)C4=NC=CC=C4C(F)(F)F",{"v":1.6,"d":"1.600"},5,3,5]
["S6724","SR1001","e8","L3900-31","in 10mM DMSO","ROR","Transmembrane Transporters","SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for  RORα and RORγ respectively.",{"v":477.4,"d":"477.40"},"1335106-03-0",{"v":95,"d":"95.00"},198.99,"<1","N/A","http://www.selleck.cn/products/sr1001.html","C15H13F6N3O4S2","Free Base","N/A","CC(=O)NC1=NC(=C(S1)[S](=O)(=O)NC2=CC=C(C=C2)C(O)(C(F)(F)F)C(F)(F)F)C",2.137,4,2,7]
["S6726","MK1064","f8","L3900-31","in 10mM DMSO","OX Receptor","GPCR & G Protein","MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM.",{"v":461.9,"d":"461.90"},"1207253-08-4",{"v":92,"d":"92.00"},199.18,"<1","N/A","http://www.selleck.cn/products/mk1064.html","C24H20ClN5O3","Free Base","N/A","COC1=C(OC)N=C(CNC(=O)C2=CC(=CN=C2C3=NC=CC=C3)C4=CC(=CN=C4)Cl)C=C1",3.298,7,1,7]
["S6727","AX-024 HCl","g8","L3900-31","in 10mM DMSO","CD markers,IFN,Interleukins,TNF-alpha","Transmembrane Transporters","AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.",375.86,"1704801-24-0",{"v":75,"d":"75.00"},199.54,{"v":4,"d":"4.00"},10.64,"http://www.selleck.cn/products/ax-024-hcl.html","C21H23ClFNO2","Hydrochloride","N/A","Cl.COC1=CC2=C(OCC(=C2C3=CC=C(F)C=C3)CN4CCCC4)C=C1",4.579,2,0,4]
["S6729","Besifovir","h8","L3900-31","in 10mM DMSO","HBV","Microbiology","Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection.",299.22,"441785-25-7",{"v":60,"d":"60.00"},200.52,{"v":60,"d":"60.00"},200.52,"http://www.selleck.cn/products/besifovir.html","C10H14N5O4P","Free Base","N/A","NC1=NC=C2N=C[N](CC3(CC3)OC[P](O)(O)=O)C2=N1",-0.821,4,1,5]
["S6730","CC-401 Hydrochloride","a9","L3900-31","in 10mM DMSO","JNK","MAPK","CC-401 is a potent inhibitor of JNK with at least 40-fold selectivity against other related kinases.",424.93,"1438391-30-0",{"v":85,"d":"85.00"},200.03,{"v":85,"d":"85.00"},200.03,"http://www.selleck.cn/products/cc-401-hydrochloride.html","C22H25ClN6O","Hydrochloride","N/A","Cl.C1CCN(CC1)CCOC2=CC(=CC=C2)C3=N[NH]C4=CC=C(C=C34)C5=NC=N[NH]5",4.527,4,2,6]
["S6733","Edonerpic maleate","b9","L3900-31","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).",407.48,"519187-97-4",{"v":81,"d":"81.00"},198.78,{"v":81,"d":"81.00"},198.78,"http://www.selleck.cn/products/edonerpic-maleate.html","C20H25NO6S","Free Base","T-817 maleate","OC1CN(CCCOCCC2=CC3=C(SC=C3)C=C2)C1.OC(=O)\\C=C/C(O)=O",{"v":-0.67,"d":"-0.670"},3,1,9]
["S6735","JD-5037","c9","L3900-31","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","JD-5037 is a peripherally restricted (PR) cannabinoid-1 receptor blocker with an IC50 value of 2 nM for CB1 receptor and > 1000 nM for CB2 receptor.",572.51,"1392116-14-1",{"v":100,"d":"100.00"},174.67,"<1","N/A","http://www.selleck.cn/products/id-5037.html","C27H27Cl2N5O3S","Free Base","N/A","CC(C)C(N=C(N[S](=O)(=O)C1=CC=C(Cl)C=C1)N2CC(C3=CC=CC=C3)C(=N2)C4=CC=C(Cl)C=C4)C(N)=O",5.552,5,2,9]
["S6741","SB-756050","d9","L3900-31","in 10mM DMSO","GPCR19","GPCR & G Protein","SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).",500.59,"447410-57-3",{"v":100,"d":"100.00"},199.76,"<1","N/A","http://www.selleck.cn/products/sb-756050.html","C21H28N2O8S2","Free Base","N/A","COC1=C(OC)C=C(C=C1)[S](=O)(=O)N2CCCN(CC2)[S](=O)(=O)C3=CC(=C(OC)C=C3)OC",1.527,8,0,8]
["S6746","APD668","e9","L3900-31","in 10mM DMSO","GPR","Endocrinology & Hormones","APD668 (JNJ28630368) is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively.",477.51,"832714-46-2",{"v":96,"d":"96.00"},201.04,"<1","N/A","http://www.selleck.cn/products/apd668.html","C21H24FN5O5S","Free Base","JNJ28630368","CC(C)OC(=O)N1CCC(CC1)OC2=NC=NC3=C2C=N[N]3C4=CC=C(C=C4F)[S](C)(=O)=O",{"v":2.67,"d":"2.670"},8,0,6]
["S6749","ASP-9521","f9","L3900-31","in 10mM DMSO","Dehydrogenase","Metabolism","ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5).",330.42,"1126084-37-4",{"v":66,"d":"66.00"},199.75,"<1","N/A","http://www.selleck.cn/products/asp-9521.html","C19H26N2O3","Free Base","N/A","COC1=CC2=C([NH]C(=C2)C(=O)N3CCC(CC3)CC(C)(C)O)C=C1",2.794,2,1,4]
["S6754","S1RA","g9","L3900-31","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.",337.42,"878141-96-9",{"v":67,"d":"67.00"},198.57,{"v":67,"d":"67.00"},198.57,"http://www.selleck.cn/products/s1ra.html","C20H23N3O2","Free Base","E-52862","CC1=CC(=N[N]1C2=CC=C3C=CC=CC3=C2)OCCN4CCOCC4",3.459,3,0,5]
["S7716","Pimitespib (TAS-116)","h9","L3900-31","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).",454.53,"1260533-36-5",{"v":91,"d":"91.00"},200.21,"<1","N/A","http://www.selleck.cn/products/tas-116.html","C25H26N8O","Free Base","N/A","CCC1=C(C=CC(=C1)C(N)=O)[N]2N=C(C(C)C)C3=C(C=CN=C23)[N]4C=NC(=C4)C5=C[N](C)N=C5",3.927,5,1,6]
["S8455","Talabostat (PT-100)","a10","L3900-31","in 10mM DMSO","DPP","Proteases","Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.",310.18,"150080-09-4",{"v":62,"d":"62.00"},199.88,{"v":62,"d":"62.00"},199.88,"http://www.selleck.cn/products/talabostat.html","C10H23BN2O6S","Free Base","Val-boroPro","CC(C)C(N)C(=O)N1CCCC1B(O)O.C[S](O)(=O)=O",{"v":0.33,"d":"0.330"},1,1,3]
["S8506","Navarixin (SCH-527123)","b10","L3900-31","in 10mM DMSO","CXCR","Immunology & Inflammation","Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.",397.42,"473727-83-2",{"v":79,"d":"79.00"},198.78,"<1","N/A","http://www.selleck.cn/products/sch-527123.html","C21H23N3O5","Free Base","MK-7123, PS-291822","CCC(NC1=C(NC2=C(O)C(=CC=C2)C(=O)N(C)C)C(=O)C1=O)C3=CC=C(C)O3",1.635,4,3,7]
["S8781","Selpercatinib (LOXO-292)","c10","L3900-31","in 10mM DMSO","c-RET","Apoptosis","Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET (c-RET) inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively.",{"v":525.6,"d":"525.60"},"2152628-33-4",{"v":25,"d":"25.00"},47.56,"<1","N/A","http://www.selleck.cn/products/loxo-292.html","C29H31N7O3","Free Base","ARRY-192","COC1=NC=C(CN2C3CC2CN(C3)C4=NC=C(C=C4)C5=CC(=C[N]6N=CC(=C56)C#N)OCC(C)(C)O)C=C1",2.884,5,0,8]
["S8814","zipalertinib","d10","L3900-31","in 10mM DMSO","EGFR","Angiogenesis","TAS6417 (CLN-081, TPC-064) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.",396.44,"1661854-97-2",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://www.selleck.cn/products/tas6417.html","C23H20N6O","Free Base","CLN-081, TPC-064,TAS6417","CC1=CC(C[N]2C3=NC=NC(=C3C(=C12)C4=CC5=CC=CC=C5N=C4)N)NC(=O)C=C",3.124,4,2,3]
["S8820","Unesbulin (PTC596)","e10","L3900-31","in 10mM DMSO","Apoptosis related,Bcl-2,BMI-1","Cell Cycle","Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.",420.34,"1610964-64-1",{"v":84,"d":"84.00"},199.84,"<1","N/A","http://www.selleck.cn/products/ptc596.html","C19H13F5N6","Free Base","N/A","CC1=NC2=CC=C(F)C=C2[N]1C3=NC(=C(F)C(=N3)N)NC4=CC=C(C=C4)C(F)(F)F",5.366,3,2,4]
["S8843","AZD7648","f10","L3900-31","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases.",{"v":380.4,"d":"380.40"},"2230820-11-6",{"v":6,"d":"6.00"},15.77,"<1","N/A","http://www.selleck.cn/products/azd7648.html","C18H20N8O2","Free Base","N/A","CN1C(=O)N(C2CCOCC2)C3=NC(=NC=C13)NC4=C[N]5N=CN=C5C=C4C",1.059,6,1,3]
["S8847","Orludodstat (BAY 2402234)","g10","L3900-31","in 10mM DMSO","Dehydrogenase","Metabolism","Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.",520.84,"2225819-06-5",{"v":100,"d":"100.00"},{"v":192,"d":"192.00"},"<1","N/A","http://www.selleck.cn/products/bay-2402234.html","C21H18ClF5N4O4","Free Base","N/A","CCN1C(=NN(C1=O)C2=C(F)C=C(C(=O)NC3=C(F)C=CC=C3Cl)C(=C2)OC(C)C(F)(F)F)CO",4.103,4,2,8]
["S8848","Futibatinib (TAS-120)","h10","L3900-31","in 10mM DMSO","FGFR","Protein Tyrosine Kinase","Futibatinib (TAS-120) is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 1.8 nM, 1.4 nM, 1.6 nM and 3.7 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.",418.45,"1448169-71-8",{"v":84,"d":"84.00"},200.74,"<1","N/A","http://www.selleck.cn/products/tas-120.html","C22H22N6O3","Free Base","N/A","COC1=CC(=CC(=C1)C#CC2=N[N](C3CCN(C3)C(=O)C=C)C4=NC=NC(=C24)N)OC",2.402,6,1,6]
["S8853","Belvarafenib (HM95573)","a11","L3900-31","in 10mM DMSO","Raf","MAPK","Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively.",478.93,"1446113-23-0",{"v":96,"d":"96.00"},200.45,"<1","N/A","http://www.selleck.cn/products/belvarafenib.html","C23H16ClFN6OS","Free Base","GDC5573, RG6185","CC1=C(NC(=O)C2=CSC3=C2N=CN=C3N)C4=C(C=C1)C(=NC=C4)NC5=C(F)C(=CC=C5)Cl",5.121,4,3,4]
["S8861","Mavacamten (MYK-461)","b11","L3900-31","in 10mM DMSO","MLCK","Cytoskeletal Signaling","Mavacamten (MYK-461, SAR439152) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders.",273.33,"1642288-47-8",{"v":55,"d":"55.00"},201.22,"<1","N/A","http://www.selleck.cn/products/myk-461.html","C15H19N3O2","Free Base","SAR439152","CC(C)N1C(=O)NC(=CC1=O)NC(C)C2=CC=CC=C2",2.093,2,2,4]
["S8874","PLX5622","c11","L3900-31","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.",395.41,"1303420-67-8",{"v":79,"d":"79.00"},199.79,"<1","N/A","http://www.selleck.cn/products/plx5622.html","C21H19F2N5O","Free Base","N/A","COC1=C(CNC2=NC(=C(CC3=C[NH]C4=NC=C(C)C=C34)C=C2)F)C=C(F)C=N1",4.577,4,2,6]
["S8878","NDI-091143","d11","L3900-31","in 10mM DMSO","ATP-citrate lyase","Metabolism","NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an  IC50 of 2.1 nM in the ADP-Glo assay.",453.84,"2375840-87-0",{"v":91,"d":"91.00"},200.51,"<1","N/A","http://www.selleck.cn/products/ndi-091143.html","C20H14ClF2NO5S","Free Base","N/A","COC(=O)C1=CC(=C(O)C(=C1)[S](=O)(=O)NC2=C(F)C=C(F)C(=C2)C3=CC=CC=C3)Cl",4.524,4,2,6]
["S8895","Ziritaxestat (GLPG1690)","e11","L3900-31","in 10mM DMSO","PDE","Metabolism","Ziritaxestat (GLPG1690) is a selective autotaxin inhibitor with an IC50 of 131 nM and Ki of 15 nM.",{"v":588.7,"d":"588.70"},"1628260-79-6",{"v":100,"d":"100.00"},169.87,"<1","N/A","http://www.selleck.cn/products/ziritaxestat.html","C30H33FN8O2S","Free Base","N/A","CCC1=C(N(C)C2=NC(=C(S2)C#N)C3=CC=C(F)C=C3)[N]4C=C(C=C(C)C4=N1)N5CCN(CC5)CC(=O)N6CC(O)C6",4.314,3,1,7]
["S8899","FF-10101","f11","L3900-31","in 10mM DMSO","FLT3","Angiogenesis","FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively.",530.66,"1472797-69-5",{"v":100,"d":"100.00"},188.44,"<1","N/A","http://www.selleck.cn/products/ff-10101.html","C29H38N8O2","Free Base","N/A","CCCNC1=NC(=NC=C1C#CCCCNC(=O)C(C)N(C)C(=O)\\C=C\\CN(C)C)NC2=CC=C(C=C2)C#N",4.153,4,3,15]
["S8901","Taletrectinib (DS-6051b)","g11","L3900-31","in 10mM DMSO","ROS1,Trk receptor","Immunology & Inflammation","Taletrectinib (DS-6051b, AB-106) is a new-generation selective ROS1/NTRK inhibitor with ic50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM for ROS1,NTRK1,NTRK2 and NTRK3,respectively.",551.61,"1505515-69-4",{"v":50,"d":"50.00"},90.64,"<1","N/A","http://www.selleck.cn/products/ds-6051b.html","C29H34FN5O5","Free Base","AB-106","CC(N)COC1=CC=C(C=C1)C2=CN=C3C=CC(=N[N]23)NC(C)C4=CC(=CC=C4)F.OC(=O)CCCCC(O)=O",{"v":2.17,"d":"2.170"},5,2,12]
["S9015","Homoharringtonine (CGX-635)","h11","L3900-31","in 10mM DMSO","STAT","JAK/STAT","Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.",545.62,"26833-87-4",{"v":10,"d":"10.00"},18.33,"N/A","N/A","https://www.selleckchem.com/products/homoharringtonine.html","C29H39NO9","free Base","Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633","COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",2.418,7,0,11]
["S9200","Pneumocandin B0","a2","L3900-32","in 10mM DMSO","Fungal","Microbiology","Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.",1065.21,"135575-42-7",{"v":100,"d":"100.00"},93.88,"N/A","N/A","https://www.selleckchem.com/products/pneumocandin-b0.html","C50H80N8O17","free base","L-688786","CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(O)C(O)NC(=O)C2C(O)CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(O)CN3C(=O)C(NC1=O)C(C)O)C(O)C(O)C4=CC=C(O)C=C4)C(O)CC(N)=O",-2.334,8,15,20]
["S9519","Fadrozole (CGS16949A)","b2","L3900-32","in 10mM DMSO","Aromatase","Endocrinology & Hormones","Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.",223.27,"102676-47-1",{"v":45,"d":"45.00"},201.55,"<1","N/A","http://www.selleck.cn/products/fadrozole.html","C14H13N3","Free Base","CGS16949A","N#CC1=CC=C(C=C1)C2CCCC3=CN=C[N]23",2.271,1,0,1]
["S9520","Lasofoxifene Tartrate","c2","L3900-32","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator (SERM) which binds with high affinity to the human estrogen receptor-α with IC50 value of 1.5 nM.",563.64,"190791-29-8",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://www.selleck.cn/products/lasofoxifene-tartrate.html","C32H37NO8","Free Base","N/A","OC(C(O)C(O)=O)C(O)=O.OC1=CC2=C(C=C1)C(C(CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4",1.554,3,3,9]
["S1024","LTI-291","d2","L3900-32","in 10mM DMSO","Others","Metabolism","LTI-291 is the first small-molecule activator of Glucocerebrosidase(GCase) for the treatment of parkinson's disease.",358.48,"1919820-28-2",{"v":36,"d":"36.00"},100.42,"<1","N/A","http://www.selleck.cn/products/lti-291.html","C20H30N4O2","Free Base","N/A","CCCCCOC1CCC(CC1)NC(=O)C2=C3N=C(C)C=C(C)[N]3N=C2",2.691,4,1,7]
["S1058","BI-1347","e2","L3900-32","in 10mM DMSO","CDK","Cell Cycle","BI-1347 is a small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.",356.42,"2163056-91-3",{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://www.selleck.cn/products/bi-1347.html","C22H20N4O","Free Base","N/A","CN(C)C(=O)C[N]1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC4=CC=CC=C34",{"v":2.54,"d":"2.540"},3,0,4]
["S2100","Temocapril","f2","L3900-32","in 10mM DMSO","ACE,RAAS","Endocrinology & Hormones","Temocapril (CS-622,temocaprilum) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.",476.61,"111902-57-9",{"v":95,"d":"95.00"},199.32,"<1","N/A","http://www.selleck.cn/products/temocapril.html","C23H28N2O5S2","Free Base","CS-622,temocaprilum","CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(CC(O)=O)C2=O)C3=CC=CS3",0.405,4,1,11]
["S2115","RG 13022","g2","L3900-32","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","RG 13022 (Tyrphostin RG13022) inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with IC50 of 4 µM.",266.29,"136831-48-6",{"v":53,"d":"53.00"},199.03,"<1","N/A","http://www.selleck.cn/products/rg-13022.html","C16H14N2O2","Free Base","Tyrphostin RG13022","COC1=CC=C(C=C1OC)\\C=C(C#N)/C2=CC=CN=C2",2.471,3,0,4]
["S2210","Sphingosine","h2","L3900-32","in 10mM DMSO","Others","Others","Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.",299.49,"123-78-4",{"v":19,"d":"19.00"},63.44,"<1","N/A","http://www.selleck.cn/products/sphingosine.html","C18H37NO2","Free Base","2-amino-4-trans-octadecene-1,3-diol,C18 Sphingosine","CCCCCCCCCCCCC/C=C/C(O)C(N)CO",4.824,0,3,15]
["S2255","BMOV","a3","L3900-32","in 10mM DMSO","Others","Others","BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV)) is a potent oral vanadium complex with anti-diabetic properties and\n\ninsulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models.",317.15,"38213-69-3",{"v":21,"d":"21.00"},66.21,"<1","N/A","http://www.selleck.cn/products/bmov.html","C12H10O7V","Free Base","Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium","CC1=C(O[V](=O)OC2=C(C)OC=CC2=O)C(=O)C=CO1",-0.286,6,0,4]
["S2307","Roquinimex","b3","L3900-32","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Roquinimex (FCF 89, Linomide, LS 2616) is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α.",308.33,"84088-42-6",{"v":62,"d":"62.00"},201.08,"<1","N/A","http://www.selleck.cn/products/roquinimex.html","C18H16N2O3","Free Base","FCF 89, Linomide, LS 2616","CN(C1=CC=CC=C1)C(=O)C2=C(O)C3=C(C=CC=C3)N(C)C2=O",1.871,2,1,2]
["S2419","Eprobemide","c3","L3900-32","in 10mM DMSO","MAO","Metabolism","Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.",282.77,"87940-60-1",{"v":57,"d":"57.00"},201.58,"<1","N/A","http://www.selleck.cn/products/eprobemide.html","C14H19ClN2O2","Free Base","Befol, LIS 630","ClC1=CC=C(C=C1)C(=O)NCCCN2CCOCC2",1.591,2,1,5]
["S2421","PF-04457845","d3","L3900-32","in 10mM DMSO","FAAH","Metabolism","PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.",455.43,"1020315-31-4",{"v":91,"d":"91.00"},199.81,"<1","N/A","https://www.selleckchem.com/products/pf-04457845.html","C23H20F3N5O2","Free Base","PF-4457845","FC(F)(F)C1=CN=C(OC2=CC(=CC=C2)C=C3CCN(CC3)C(=O)NC4=NN=CC=C4)C=C1",4.371,5,1,5]
["S2426","Tirapazamine","e3","L3900-32","in 10mM DMSO","Others","Others","Tirapazamine (NSC 130181, SR 259075, SR 4233, Tirazone, WIN 59075) is a new anticancer drug in solid tumours. Tirapazamine exhibits preferential tumour cell killing and high specific toxicity to cells at low oxygen tensions.",178.15,"27314-97-2",{"v":36,"d":"36.00"},202.08,"<1","N/A","http://www.selleck.cn/products/tirapazamine.html","C7H6N4O2","Free Base","NSC 130181, SR 259075, SR 4233, Tirazone, WIN 59075","NC1=[N+]([O-])C2=CC=CC=C2[N+](=N1)[O-]",-0.565,1,1,0]
["S2434","IDRA-21","f3","L3900-32","in 10mM DMSO","GluR","Neuronal Signaling","IDRA-21 is a partial allosteric modulator of AMPA receptor desensitization. IDRA-21 is a potent cognition-enhancing drug virtually devoid of neurotoxic liability.",232.69,"22503-72-6",{"v":47,"d":"47.00"},201.99,"<1","N/A","http://www.selleck.cn/products/idra-21.html","C8H9ClN2O2S","Free Base","N/A","CC1NC2=CC=C(Cl)C=C2[S](=O)(=O)N1",1.193,2,2,0]
["S2436","Pranidipine","g3","L3900-32","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Pranidipine (Acalas, OPC 13340) is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.",448.47,"99522-79-9",{"v":90,"d":"90.00"},200.68,"<1","N/A","http://www.selleck.cn/products/pranidipine.html","C25H24N2O6","Free Base","Acalas, OPC 13340","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC\\C=C\\C3=CC=CC=C3)C",3.817,4,1,9]
["S2465","CPI-1189","h3","L3900-32","in 10mM DMSO","TNF-alpha","Apoptosis","CPI-1189 (REN 1654, REN 1189) is the proapoptotic cytokine tumor necrosis factor (TNF) alpha inhibitor. CPI-1189 intracellularly inhibits the p38 mitogen-activated protein kinase phosphoactivation and shows neuroprotective effects.",234.29,"183619-38-7",{"v":47,"d":"47.00"},200.61,"<1","N/A","http://www.selleck.cn/products/cpi-1189.html","C13H18N2O2","Free Base","REN 1654, REN 1189","CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C",1.089,2,2,3]
["S2488","VTP-27999 TFA","a4","L3900-32","in 10mM DMSO","RAAS","Endocrinology & Hormones","VTP-27999 TFA (VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate) is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin.",{"v":639.1,"d":"639.10"},"1013937-63-7",{"v":100,"d":"100.00"},156.47,{"v":100,"d":"100.00"},156.47,"http://www.selleck.cn/products/vtp-27999-tfa.html","C28H42ClF3N4O7","TFA","VTP-27999 Trifluoroacetate, VTP-27999 2,2,2-trifluoroacetate","CNC(CNC(=O)N1CCCC(C1)C(OCCNC(=O)OC)C2=CC(=CC=C2)Cl)CC3CCCOC3.OC(=O)C(F)(F)F",0.798,6,3,13]
["S2600","Fexinidazole","b4","L3900-32","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fexinidazole (HOE-239, Fexinidazole Winthrop) is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness).",279.31,"59729-37-2",{"v":56,"d":"56.00"},200.49,"<1","N/A","http://www.selleck.cn/products/fexinidazole.html","C12H13N3O3S","Free Base","HOE-239, Fexinidazole Winthrop","CSC1=CC=C(OCC2=NC=C([N]2C)[N+]([O-])=O)C=C1",2.244,2,0,5]
["S2643","4-IPP","c4","L3900-32","in 10mM DMSO","MIF","Immunology & Inflammation","4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) and a specific suicide substrate for MIF. 4-IPP can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro.",282.08,"41270-96-6",{"v":56,"d":"56.00"},198.53,"<1","N/A","http://www.selleck.cn/products/4-ipp.html","C10H7IN2","Free Base","4-Iodo-6-phenylpyrimidine","IC1=CC(=NC=N1)C2=CC=CC=C2",3.103,2,0,1]
["S2644","Lerisetron","d4","L3900-32","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.",292.38,"143257-98-1",{"v":58,"d":"58.00"},198.37,"<1","N/A","http://www.selleck.cn/products/lerisetron.html","C18H20N4","Free Base","F 0930, F 0930RS","C1CN(CCN1)C2=NC3=C(C=CC=C3)[N]2CC4=CC=CC=C4",{"v":3.26,"d":"3.260"},1,1,3]
["S2645","SIB 1757","e4","L3900-32","in 10mM DMSO","GluR","Neuronal Signaling","SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8.",213.24,"31993-01-8",{"v":22,"d":"22.00"},103.17,"<1","N/A","http://www.selleck.cn/products/sib-1757.html","C12H11N3O","Free Base","N/A","CC1=NC(=C(O)C=C1)N=NC2=CC=CC=C2",3.628,3,1,2]
["S2935","Nicotinamide Riboside Chloride","f4","L3900-32","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.",{"v":290.7,"d":"290.70"},"23111-00-4",{"v":58,"d":"58.00"},199.52,{"v":58,"d":"58.00"},199.52,"http://www.selleck.cn/products/nicotinamide-riboside-chloride.html","C11H15ClN2O5","Chloride","N/A","[Cl-].NC(=O)C1=CC=C[N+](=C1)C2OC(CO)C(O)C2O",-3.882,2,4,3]
["S6647","Bardoxolone","g4","L3900-32","in 10mM DMSO","Nrf2","Immunology & Inflammation","Bardoxolone (CDDO, RTA 401), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2  that induce programmed cell death (apoptosis) in cancer cells.",491.66,"218600-44-3",{"v":6,"d":"6.00"},{"v":12.2,"d":"12.20"},"<1","N/A","http://www.selleck.cn/products/bardoxolone.html","C31H41NO4","Free Base","CDDO, RTA 401","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C5(C)C=C(C#N)C(=O)C(C)(C)C5CCC34C)C(O)=O",5.573,3,0,1]
["S6649","E7046 (ER-886406)","h4","L3900-32","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","E7046 (ER-886406, Palupiprant, AN0025) is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM.",483.39,"1369489-71-3",{"v":100,"d":"100.00"},206.87,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/e7046.html","C22H18F5N3O4","Free Base","Palupiprant, AN0025","CC(NC(=O)C1=C(OC2=CC=CC(=C2)C(F)(F)F)[N](C)N=C1C(F)F)C3=CC=C(C=C3)C(O)=O",4.787,4,1,8]
["S6656","VAS2870","a5","L3900-32","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.",360.39,"722456-31-7",{"v":36,"d":"36.00"},99.89,"<1","N/A","http://www.selleck.cn/products/vas2870.html","C18H12N6OS","Free Base","N/A","C([N]1N=NC2=C1N=CN=C2SC3=NC4=C(O3)C=CC=C4)C5=CC=CC=C5",4.369,6,0,4]
["S6658","ETC-206 (AUM 001)","b5","L3900-32","in 10mM DMSO","MNK","MAPK","ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively.",408.45,"1464151-33-4",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://www.selleck.cn/products/etc-206.html","C25H20N4O2","Free Base","ETC-1907206","O=C(N1CCOCC1)C2=CC=C(C=C2)C3=C[N]4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3",3.016,3,0,3]
["S6659","Rimegepant (BMS-927711)","c5","L3900-32","in 10mM DMSO","CGRP Receptor","GPCR & G Protein","Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.",534.56,"1289023-67-1",{"v":100,"d":"100.00"},187.07,"<1","N/A","http://www.selleck.cn/products/bms-927711.html","C28H28F2N6O3","Free Base","BHV-3000","NC1C(CCC(OC(=O)N2CCC(CC2)N3C(=O)NC4=NC=CC=C34)C5=NC=CC=C15)C6=CC=CC(=C6F)F",2.898,5,2,4]
["S6662","AST-487 (NVP-AST487)","d5","L3900-32","in 10mM DMSO","Bcr-Abl,c-Kit,c-RET,FLT3","Angiogenesis","AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.",529.56,"630124-46-8",{"v":100,"d":"100.00"},188.84,"<1","N/A","http://www.selleck.cn/products/ast-487.html","C26H30F3N7O2","Free Base","N/A","CCN1CCN(CC1)CC2=C(C=C(NC(=O)NC3=CC=C(OC4=NC=NC(=C4)NC)C=C3)C=C2)C(F)(F)F",4.513,4,3,9]
["S6663","Resmetirom (MGL-3196)","e5","L3900-32","in 10mM DMSO","THR","Metabolism","Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.",435.22,"920509-32-6",{"v":87,"d":"87.00"},{"v":199.9,"d":"199.90"},"<1","N/A","http://www.selleck.cn/products/mgl-3196.html","C17H12Cl2N6O4","Free Base","VIA-3196","CC(C)C1=CC(=NNC1=O)OC2=C(Cl)C=C(C=C2Cl)N3N=C(C#N)C(=O)NC3=O",3.021,6,2,4]
["S6665","Sparsentan (PS-433540, RE-021)","f5","L3900-32","in 10mM DMSO","Angiotensin Receptor,Endothelin Receptor","GPCR & G Protein","Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.",592.75,"254740-64-2",{"v":100,"d":"100.00"},168.71,"<1","N/A","http://www.selleck.cn/products/sparsentan.html","C32H40N4O5S","Free Base","DARA","CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C(=C3)COCC)C4=CC=CC=C4[S](=O)(=O)NC5=NOC(=C5C)C",5.728,7,1,12]
["S6676","Ebselen","g5","L3900-32","in 10mM DMSO","COVID-19,HIV","Microbiology","Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.",274.18,"60940-34-3",{"v":55,"d":"55.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://www.selleck.cn/products/ebselen.html","C13H9NOSe","Free Base","DR 3305, SPI-1005, PZ-51, CCG-39161","O=C1N([Se]C2=C1C=CC=C2)C3=CC=CC=C3",3.227,1,0,1]
["S6689","Merimepodib","h5","L3900-32","in 10mM DMSO","Dehydrogenase,HCV","Metabolism","Merimepodib (Merimempodib, MMPD, VI-21,497, VX-497) is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.",452.46,"198821-22-6",{"v":90,"d":"90.00"},198.91,"<1","N/A","http://www.selleck.cn/products/merimepodib.html","C23H24N4O6","Free Base","Merimempodib; MMPD; VI-21,497; VX-497","COC1=CC(=CC=C1C2=CN=CO2)NC(=O)NC3=CC(=CC=C3)CNC(=O)OC4CCOC4",1.762,7,3,8]
["S8500","BAY1125976","a6","L3900-32","in 10mM DMSO","Akt","PI3K/Akt/mTOR","BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).",383.45,"1402608-02-9",{"v":11,"d":"11.00"},28.69,"<1","N/A","http://www.selleck.cn/products/bay1125976.html","C23H21N5O","Free Base","N/A","NC(=O)C1=N[N]2C(=NC(=C2C3=CC=CC=C3)C4=CC=C(C=C4)C5(N)CCC5)C=C1",3.335,3,2,4]
["S8882","ODM-203","b6","L3900-32","in 10mM DMSO","FGFR,VEGFR","Angiogenesis","ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.",505.54,"1430723-35-5",{"v":100,"d":"100.00"},197.81,"<1","N/A","http://www.selleck.cn/products/odm-203.html","C26H21F2N5O2S","Free Base","N/A","C[N]1C=C(C=N1)C2=CC3=C(C=C2)[N](C=N3)C4=CC(=CC(=C4)N[S](=O)(=O)C5CC5)C6=C(F)C=C(F)C=C6",4.626,4,1,6]
["S8893","Firsocostat (GS-0976)","c6","L3900-32","in 10mM DMSO","Acetyl-CoA carboxylase","Metabolism","Firsocostat (GS-0976, NDI-010976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC)  with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively.",569.63,"1434635-54-7",{"v":100,"d":"100.00"},175.55,"<1","N/A","http://www.selleck.cn/products/nd-630.html","C28H31N3O8S","Free Base","NDI-010976, ND-630","COC1=CC=CC=C1C(CN2C(=O)N(C(=O)C3=C2SC(=C3C)C4=NC=CO4)C(C)(C)C(O)=O)OC5CCOCC5",2.946,8,0,9]
["S8907","Dapansutrile","d6","L3900-32","in 10mM DMSO","NLRP3","Immunology & Inflammation","Dapansutrile is a novel and selective NLRP3 inflammasome inhibitor.",133.17,"54863-37-5",{"v":100,"d":"100.00"},750.92,{"v":100,"d":"100.00"},750.92,"https://www.selleckchem.com/products/dapansutrile.html","C4H7NO2S","Free Base","N/A","C[S](=O)(=O)CCC#N",-0.242,2,0,2]
["S8944","G150","e6","L3900-32","in 10mM DMSO","cGAS","Metabolism","G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM.",391.25,"2369751-30-2",{"v":78,"d":"78.00"},199.36,"<1","N/A","http://www.selleck.cn/products/g150.html","C18H16Cl2N4O2","Free Base","N/A","NC1=NC=C(C=C1)C2=CC(=C(Cl)C3=C2C4=C(CCN(C4)C(=O)CO)[NH]3)Cl",2.353,2,3,2]
["S8949","Olutasidenib (FT-2102)","f6","L3900-32","in 10mM DMSO","Dehydrogenase","Metabolism","Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively.",354.79,"1887014-12-1",{"v":71,"d":"71.00"},200.12,"<1","N/A","http://www.selleck.cn/products/olutasidenib-ft-2102.html","C18H15ClN4O2","Free Base","N/A","CC(NC1=CC=C(C#N)N(C)C1=O)C2=CC3=C(NC2=O)C=CC(=C3)Cl",1.234,2,2,3]
["S9131","Punicalagin","g6","L3900-32","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects., Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.",1084.72,"65995-63-3",{"v":100,"d":"100.00"},92.19,{"v":100,"d":"100.00"},92.19,"http://www.selleck.cn/products/punicalagin.html","C48H28O30","Free Base","N/A","OC1COC(=O)C2=CC(=C(O)C(=C2C3=C4C(=O)OC5=C(O)C(=C(C6=C5C4=C(OC6=O)C(=C3O)O)C7=C(C=C(O)C(=C7O)O)C(=O)OC1C8OC(=O)C9=CC(=C(O)C(=C9C%10=C(C=C(O)C(=C%10O)O)C(=O)OC8C=O)O)O)O)O)O",3.128,13,17,2]
["S9144","Solasonine","h6","L3900-32","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.",884.06,"19121-58-5",{"v":100,"d":"100.00"},113.11,"<1","N/A","http://www.selleck.cn/products/solasonine.html","C45H73NO16","Free Base","N/A","CC1CCC2(NC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C7OC9OC(C)C(O)C(O)C9O",0.015,7,10,8]
["S9145","Solamargine","a7","L3900-32","in 10mM DMSO","P-gp","Neuronal Signaling","Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.",868.06,"20311-51-7",{"v":100,"d":"100.00"},{"v":115.2,"d":"115.20"},"<1","N/A","http://www.selleck.cn/products/solamargine.html","C45H73NO15","Free Base","N/A","CC1CCC2(NC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",0.903,7,9,7]
["S0039","BI-409306","b7","L3900-32","in 10mM DMSO","PDE","Metabolism","BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.",311.34,"1189767-28-9",{"v":62,"d":"62.00"},199.14,"˂1","N/A","http://www.selleckchem.com/products/bi-409306.html","C16H17N5O2","Free Base","SUB 166499","O=C1NC(=NC2=C1C=N[N]2C3CCOCC3)CC4=CC=CC=N4",0.421,5,1,3]
["S0209","BVT 2733","c7","L3900-32","in 10mM DMSO","Dehydrogenase","Metabolism","BVT 2733, a new small molecule, is a non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).",428.96,"376640-41-4",{"v":86,"d":"86.00"},200.48,"˂1","N/A","http://www.selleckchem.com/products/bvt-2733.html","C17H21ClN4O3S2","Free Base","N/A","CN1CCN(CC1)C(=O)CC2=CSC(=N2)N[S](=O)(=O)C3=C(C)C(=CC=C3)Cl",{"v":2.3,"d":"2.300"},4,1,5]
["S0222","Lvguidingan","d7","L3900-32","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Lvguidingan (Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide) is an anticonvulsant/antiepileptic agent. Lvguidingan (Anticonvulsant 7903) is found to be able to increase the concentration of 5-HT and 5-HIAA in mice brain.",272.17,"82351-05-1",{"v":54,"d":"54.00"},198.41,"˂1","N/A","http://www.selleckchem.com/products/lvguidingan.html","C13H15Cl2NO","Free Base","Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide","CCC(C)NC(=O)\\C=C\\C1=CC(=C(Cl)C=C1)Cl",4.084,1,1,4]
["S0276","GSK-2881078","e7","L3900-32","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","GSK 2881078 is a nonsteroidal selective modulator of androgen receptor that is potentially used for the treatment of cachexia.",330.33,"1539314-06-1",{"v":66,"d":"66.00"},{"v":199.8,"d":"199.80"},"˂1","N/A","http://www.selleckchem.com/products/gsk-2881078.html","C14H13F3N2O2S","Free Base","N/A","CC(C[S](C)(=O)=O)[N]1C=CC2=C1C=CC(=C2C(F)(F)F)C#N",3.126,2,0,4]
["S0295","Anavex 2-73 HCl","f7","L3900-32","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ1 Receptor agonist with IC50 of 0.86 μM.",317.85,"195615-84-0",{"v":64,"d":"64.00"},201.35,{"v":64,"d":"64.00"},201.35,"http://www.selleckchem.com/products/anavex-2-73.html","C19H24ClNO","Hydrochloride","Blarcamesine hydrochloride, AVex-73 hydrochloride, AE-37 hydrochloride","Cl.CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3",3.722,1,0,4]
["S0436","Pleconaril","g7","L3900-32","in 10mM DMSO","Enterovirus","Microbiology","Pleconaril (APO-P001, Picovir, VP 63843, WIN 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with IC50 of < 0.050 μM.",381.35,"153168-05-9",{"v":76,"d":"76.00"},199.29,"˂1","N/A","http://www.selleckchem.com/products/pleconaril.html","C18H18F3N3O3","Free Base","APO-P001, Picovir, VP 63843, WIN 63843","CC1=NOC(=C1)CCCOC2=C(C)C=C(C=C2C)C3=NOC(=N3)C(F)(F)F",4.492,6,0,7]
["S0462","NS-1619","h7","L3900-32","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.",362.23,"153587-01-0",{"v":72,"d":"72.00"},198.77,"˂1","N/A","http://www.selleckchem.com/products/ns-161.html","C15H8F6N2O2","Free Base","N/A","OC1=CC=C(C=C1N2C(=O)NC3=CC(=CC=C23)C(F)(F)F)C(F)(F)F",4.117,1,2,3]
["S0470","RSV604","a8","L3900-32","in 10mM DMSO","RSV","Microbiology","RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. RSV604 has significant potential for the effective treatment of RSV disease. Phase 2.",388.39,"676128-63-5",{"v":78,"d":"78.00"},200.83,"˂1","N/A","http://www.selleckchem.com/products/rsv604.html","C22H17FN4O2","Free Base","A-60444","FC1=CC=CC=C1NC(=O)NC2N=C(C3=CC=CC=C3)C4=CC=CC=C4NC2=O",3.689,3,3,3]
["S0471","Olitigaltin (TD-139)","b8","L3900-32","in 10mM DMSO","Galectin","Immunology & Inflammation","Olitigaltin (TD-139, GB0-139) is a potent and selective inhibitor of galectin-3 with Kd of 0.036 µM over galectin-1 and galectin-7 with Kd of 2.2 µM and 32 µM, respectively. TD-139 is used potentially for the treatment of idiopathic pulmonary fibrosis (IPF).",648.64,"1450824-22-2",{"v":100,"d":"100.00"},154.17,"˂1","N/A","http://www.selleckchem.com/products/td139.html","C28H30F2N6O8S","Free Base","GB0-139","OCC1OC(SC2OC(CO)C(O)C(C2O)[N]3C=C(N=N3)C4=CC(=CC=C4)F)C(O)C(C1O)[N]5C=C(N=N5)C6=CC(=CC=C6)F",{"v":1.53,"d":"1.530"},6,6,8]
["S0487","Sulfatinib","c8","L3900-32","in 10mM DMSO","CSF-1R,FGFR,VEGFR","Protein Tyrosine Kinase","Sulfatinib (HMPL-012, Sufatinib, Surfatinib, Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1, VEGFR2, VEGFR3, FGFR1 and CSF1R with IC50 of 2 nM, 24 nM, 1 nM, 15 nM and 4 nM, respectively. Sulfatinib shows encouraging antitumor activity and manageable toxicities in patients with advanced NETs.",480.58,"1308672-74-3",{"v":96,"d":"96.00"},199.76,"˂1","N/A","http://www.selleckchem.com/products/sulfatinib.html","C24H28N6O3S","Free Base","HMPL-012, Sufatinib, Surfatinib, Surufatinib","CN(C)CCN[S](=O)(=O)CC1=CC(=CC=C1)NC2=NC=CC(=N2)OC3=CC4=C([NH]C(=C4)C)C=C3",3.717,5,3,10]
["S0523","SB 4","d8","L3900-32","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB 4 is a potent and selective agonist of bone morphogenetic protein 4 (BMP4) signaling with EC50 of 74 nM. SB 4 enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.",{"v":320.2,"d":"320.20"},"100874-08-6",{"v":64,"d":"64.00"},199.88,"˂1","N/A","http://www.selleckchem.com/products/sb-4.html","C14H10BrNOS","Free Base","Benepali, Brenzys, Etanercept biosimilar","BrC1=CC=C(CSC2=NC3=CC=CC=C3O2)C=C1",4.771,2,0,3]
["S2121","Licofelone (ML3000)","e8","L3900-32","in 10mM DMSO","COX","Neuronal Signaling","Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.",379.88,"156897-06-2",{"v":19,"d":"19.00"},50.02,"<1","N/A","http://www.selleckchem.com/products/licofelone.html","C23H22ClNO2","Free Base","ML3000","CC1(C)C[N]2C(=C(C3=CC=C(Cl)C=C3)C(=C2C1)C4=CC=CC=C4)CC(O)=O",{"v":5.78,"d":"5.780"},1,0,4]
["S2288","Rubitecan","f8","L3900-32","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.",393.35,"91421-42-0",{"v":58,"d":"58.00"},147.45,"<1","N/A","http://www.selleckchem.com/products/rubitecan.html","C20H15N3O6","Free Base","9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=C(C5=C4)[N+]([O-])=O)C2=O",{"v":1.64,"d":"1.640"},4,0,2]
["S2427","Triglycidyl Isocyanurate (Teroxirone)","g8","L3900-32","in 10mM DMSO","DNA/RNA Synthesis,p53","Apoptosis","Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.",297.26,"2451-62-9",{"v":59,"d":"59.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/triglycidyl-isocyanurat.html","C12H15N3O6","Free Base","Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC","O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4",-0.894,6,0,6]
["S2477","2'-Deoxy-5-Fluorocytidine","h8","L3900-32","in 10mM DMSO","DNA Methyltransferase","Endocrinology & Hormones","2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors.",245.21,"10356-76-0",{"v":49,"d":"49.00"},199.83,{"v":12,"d":"12.00"},48.94,"http://www.selleckchem.com/products/2-feoxy-5-fluorocytidine.html","C9H12FN3O4","Free Base","5-fluoro-2(')-deoxycytidine, FCdR","NC1=NC(=O)N(C=C1F)C2CC(O)C(CO)O2",{"v":-1.72,"d":"-1.720"},3,3,2]
["S2592","Emapunil (AC 5216)","a9","L3900-32","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","Emapunil (AC-5216, 18 kiloDalton Translocator Protein, XBD173) is a novel mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO) ligand. Emapunil(AC-5216) showes high affinity for MBRs prepared from rat whole brain with Ki of 0.297 nM and IC50 of 3.04 nM and 2.73 nM at rat glioma cells and human glioma cells, respectively.",401.46,"226954-04-7",{"v":80,"d":"80.00"},199.27,"<1","N/A","http://www.selleckchem.com/products/emapunil.html","C23H23N5O2","Free Base","18 kiloDalton Translocator Protein, XBD173","CCN(CC1=CC=CC=C1)C(=O)CN2C(=O)N(C)C3=C2N=C(N=C3)C4=CC=CC=C4",2.683,4,0,6]
["S2595","FK-3311","b9","L3900-32","in 10mM DMSO","COX","Immunology & Inflammation","FK-3311 (COX-2 Inhibitor V) is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.",341.33,"116686-15-8",{"v":68,"d":"68.00"},199.22,"<1","N/A","http://www.selleckchem.com/products/fk-3311.html","C15H13F2NO4S","Free Base","COX-2 Inhibitor V","CC(=O)C1=CC=C(N[S](C)(=O)=O)C(=C1)OC2=CC=C(F)C=C2F",2.452,4,1,5]
["S2649","SB 200646","c9","L3900-32","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.",{"v":266.3,"d":"266.30"},"143797-63-1",{"v":53,"d":"53.00"},199.02,"˂1","N/A","http://www.selleckchem.com/products/sb-200646.html","C15H14N4O","Free Base","SB 200646A","C[N]1C=CC2=C1C=CC(=C2)NC(=O)NC3=CC=CN=C3",1.871,2,2,2]
["S6615","ATB 346","d9","L3900-32","in 10mM DMSO","Apoptosis related,COX,Others","Immunology & Inflammation","ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.",365.45,"1226895-20-0",{"v":73,"d":"73.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/atb-346.html","C21H19NO3S","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(=O)OC3=CC=C(C=C3)C(N)=S",4.521,3,1,6]
["S6722","Seclidemstat (SP-2577)","e9","L3900-32","in 10mM DMSO","LSD1","Methylation","Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.",450.94,"1423715-37-0",{"v":90,"d":"90.00"},199.58,"˂1","N/A","http://www.selleckchem.com/products/seclidemstat.html","C20H23ClN4O4S","Free Base","SP-2577 mesylate","CN1CCN(CC1)[S](=O)(=O)C2=CC=CC(=C2)C(=O)N\\N=C(C)\\C3=C(O)C=CC(=C3)Cl",{"v":2.16,"d":"2.160"},4,2,5]
["S6774","TP-3654","f9","L3900-32","in 10mM DMSO","Pim","JAK/STAT","TP-3654 is the second-generation PIM inhibitor with Ki values of 5 nM, 239 nM, and 42 nM for PIM-1, PIM-2 and PIM-3, respectively.",418.46,"1361951-15-6",{"v":84,"d":"84.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/tp-3654.html","C22H25F3N4O","Free Base","N/A","CC(C)(O)C1CCC(CC1)NC2=N[N]3C(=NC=C3C4=CC=CC(=C4)C(F)(F)F)C=C2",4.874,2,1,5]
["S6782","Anle138b","g9","L3900-32","in 10mM DMSO","Others","Neuronal Signaling","Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.",343.17,"882697-00-9",{"v":69,"d":"69.00"},201.07,"<1","N/A","http://www.selleckchem.com/products/anle138b.html","C16H11BrN2O2","Free Base","N/A","BrC1=CC(=CC=C1)C2=CC(=N[NH]2)C3=CC=C4OCOC4=C3",4.547,3,1,2]
["S6813","Mobocertinib (TAK788)","h9","L3900-32","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Mobocertinib (TAK788, AP32788), an investigational TKI, is a potent, selective preclinical inhibitor of epidermal growth factor receptor (EGFR) and HER2 mutations. Mobocertinib (TAK788) is an antineoplastic agent.",{"v":585.7,"d":"585.70"},"1847461-43-1",{"v":9,"d":"9.00"},15.37,"<1","N/A","http://www.selleckchem.com/products/tak788.html","C32H39N7O4","Free Base","AP32788","COC1=C(NC2=NC=C(C(=O)OC(C)C)C(=N2)C3=C[N](C)C4=CC=CC=C34)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",5.252,6,2,13]
["S6814","GS-441524","a10","L3900-32","in 10mM DMSO","Antiviral","Microbiology","GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.",291.26,"1191237-69-0",{"v":58,"d":"58.00"},199.13,"<1","N/A","http://www.selleckchem.com/products/gs-441524.html","C12H13N5O4","Free Base","N/A","NC1=NC=N[N]2C1=CC=C2C3(OC(CO)C(O)C3O)C#N",{"v":-1.43,"d":"-1.430"},3,4,2]
["S6838","BCTC","b10","L3900-32","in 10mM DMSO","TRP Channel","Transmembrane Transporters","BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.",372.89,"393514-24-4",{"v":74,"d":"74.00"},198.45,"˂1","N/A","http://www.selleckchem.com/products/bctc.html","C20H25ClN4O","Free Base","N/A","CC(C)(C)C1=CC=C(NC(=O)N2CCN(CC2)C3=NC=CC=C3Cl)C=C1",4.234,2,1,3]
["S6843","Vorolanib","c10","L3900-32","in 10mM DMSO","PDGFR,VEGFR","Protein Tyrosine Kinase","Vorolanib (X-82,CM082) is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.",{"v":439.4,"d":"439.40"},"1013920-15-4",{"v":89,"d":"89.00"},202.55,"˂1","N/A","http://www.selleckchem.com/products/vorolanib.html","C23H26FN5O3","Free Base","X-82,CM082","CN(C)C(=O)N1CCC(C1)NC(=O)C2=C(C)[NH]C(=C2C)\\C=C\\3C(=O)NC4=C3C=C(F)C=C4",1.671,3,3,3]
["S6844","Zatolmilast (BPN14770)","d10","L3900-32","in 10mM DMSO","PDE","Metabolism","Zatolmilast (BPN14770) is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.",{"v":405.8,"d":"405.80"},"1606974-33-7",{"v":81,"d":"81.00"},199.61,"˂1","N/A","http://www.selleckchem.com/products/bpn14770.html","C21H15ClF3NO2","Free Base","N/A","OC(=O)CC1=CC=C(CC2=CC(=NC(=C2)C(F)(F)F)C3=CC=CC(=C3)Cl)C=C1",{"v":6.3,"d":"6.300"},2,0,6]
["S6848","3'-Fluoro-3'-deoxythymidine (Alovudine)","e10","L3900-32","in 10mM DMSO","DNA/RNA Synthesis,HIV,Reverse Transcriptase","Microbiology","3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the  chemotherapy of pancreatic cancer.",244.22,"25526-93-6",{"v":49,"d":"49.00"},200.64,{"v":20,"d":"20.00"},81.89,"http://www.selleckchem.com/products/3-fluoro-3-deoxythymidine.html","C10H13FN2O4","Free Base","CL 184824, FddThd, FLT, MIV-310","CC1=CN(C2CC(F)C(CO)O2)C(=O)NC1=O",-0.298,3,2,2]
["S7688","Ki20227","f10","L3900-32","in 10mM DMSO","c-Kit,CSF-1R,PDGFR,VEGFR","Protein Tyrosine Kinase","Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase(CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR-2), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor beta (PDGFRβ), respectively.",480.54,"623142-96-1",{"v":96,"d":"96.00"},199.78,"˂1","N/A","http://www.selleckchem.com/products/ki20227.html","C24H24N4O5S","Free Base","KI-20227","COC1=C(NC(=O)NC(C)C2=NC=CS2)C=CC(=C1)OC3=C4C=C(OC)C(=CC4=NC=C3)OC",{"v":3.36,"d":"3.360"},7,2,8]
["S8784","PQR620","g10","L3900-32","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.",445.47,"1927857-56-4",{"v":20,"d":"20.00"},{"v":44.9,"d":"44.90"},"˂1","N/A","http://www.selleckchem.com/products/pqr620.html","C21H25F2N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3C4CCC3COC4)N5C6CCC5COC6)C(=C1)C(F)F",2.434,6,1,4]
["S8889","MZ-1","h10","L3900-32","in 10mM DMSO","Epigenetic Reader Domain,PROTAC","Epigenetics","MZ-1 is a PROTAC degrader of bromodomain-containing protein 4 (BRD4). MZ-1 binds to the Brd bromodomain with Kd of 62 nM, 60 nM, 21 nM, 13 nM, 39 nM and 15 nM for Brd2BD1, Brd2BD2, Brd3BD1, Brd3BD2, Brd4BD1 and Brd4BD2.",1002.64,"1797406-69-9",{"v":100,"d":"100.00"},99.74,"<1","N/A","http://www.selleckchem.com/products/mz-1.html","C49H60ClN9O8S2","Free Base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(O)CC4C(=O)NCC5=CC=C(C=C5)C6=C(C)N=CS6)C(C)(C)C)N=C2C7=CC=C(Cl)C=C7)C",3.605,11,4,21]
["S8892","JHU395","a11","L3900-32","in 10mM DMSO","Glutaminase","Proteases","JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.",447.48,"2079938-92-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/jhu395.html","C22H29N3O7","Free Base","N/A","CC(C)OC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)OC(OC(=O)C(C)(C)C)C1=CC=CC=C1",4.148,7,1,14]
["S8915","C75 trans","b11","L3900-32","in 10mM DMSO","Fatty Acid Synthase","Metabolism","C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.",254.32,"191282-48-1",{"v":51,"d":"51.00"},200.53,"<1","N/A","http://www.selleckchem.com/products/c75.html","C14H22O4","Free Base","trans-C75, (±)-C75","CCCCCCCCC1OC(=O)C(=C)C1C(O)=O",3.711,3,0,8]
["S8922","TBK1/IKKε-IN-1(compound 1)","c11","L3900-32","in 10mM DMSO","IκB/IKK,TBK1","NF-κB","TBK1/IKKε-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and  IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo.",513.59,"1893397-65-3",{"v":10,"d":"10.00"},19.47,"˂1","N/A","http://www.selleckchem.com/products/tbk1-IKKe-in-1-compound1.html","C28H31N7O3","Free Base","N/A","N#CC1=CC(=CC=C1OC2CCOCC2)C3=NC=NC(=N3)NC4=CC=C(C=C4)N5CCN(CC5)C6COC6",3.176,6,1,7]
["S8933","ONO-7475","d11","L3900-32","in 10mM DMSO","Axl,Mertk","Protein Tyrosine Kinase","ONO-7475 is a potent, selective, and orally active novel inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 of 0.7 nM and 1.0 nM for AXL and MER, respectively. ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells. ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells.",562.57,"1646839-59-9",{"v":100,"d":"100.00"},177.76,"<1","N/A","http://www.selleckchem.com/products/ono-7475.html","C32H26N4O6","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=CC=N2)OC3=CN=C(NC(=O)C4=CC5=C(CCCC5=O)N(C4=O)C6=CC=CC=C6)C=C3",3.872,8,1,7]
["S8943","VLX600","e11","L3900-32","in 10mM DMSO","Autophagy,Mitochondrial Metabolism,OXPHOS","Apoptosis","VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumor spheroids in a synergistic manner. VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation. VLX600 induces autophagy and mitochondrial inhibition with antitumor activity.",317.35,"327031-55-0",{"v":13,"d":"13.00"},40.96,"˂1","N/A","http://www.selleckchem.com/products/vlx600.html","C17H15N7","Free Base","N/A","CC1=C2[NH]C3=NC(=NN=C3C2=CC=C1)N\\N=C(C)/C4=CC=CC=N4",3.589,5,2,3]
["S8945","BAY-1816032","f11","L3900-32","in 10mM DMSO","Serine/threonin kinase","Metabolism","BAY-1816032 is a potent and oral available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase with IC50 of 6.1 nM for recombinant catalytic domain of human BUB1. BAY-1816032 has antitumor activity.",534.51,"1891087-61-8",{"v":50,"d":"50.00"},93.54,"<1","N/A","http://www.selleckchem.com/products/bay-1816032.html","C27H24F2N6O4","Free Base","N/A","COC1=C(NC2=NC(=NC=C2OC)C3=N[N](CC4=C(F)C=C(OCCO)C=C4F)C5=C3C=CC=C5)C=CN=C1",4.294,7,2,10]
["S8947","SX-682","g11","L3900-32","in 10mM DMSO","CXCR","Immunology & Inflammation","SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.",{"v":467.2,"d":"467.20"},"1648843-04-2",{"v":93,"d":"93.00"},199.06,"˂1","N/A","http://www.selleckchem.com/products/sx-682.html","C19H14BF4N3O4S","Free Base","N/A","OB(O)C1=CC=C(OC(F)(F)F)C=C1CSC2=NC=C(C=N2)C(=O)NC3=CC=C(F)C=C3",5.761,4,1,8]
["S8953","ASP4132","h11","L3900-32","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.",937.06,"1640294-30-9",{"v":100,"d":"100.00"},106.72,"<1","N/A","http://www.selleckchem.com/products/asp4132.html","C46H51F3N6O8S2","Free Base","N/A","COC1=NC=C(CN2CCC(CC2)C3=CC=C4[NH]C(=NC4=C3)C(=O)N5CCN(CC5)CC6=CC=C(C=C6)C(F)(F)F)C=C1.CC7=CC=C(C=C7)[S](O)(=O)=O.CC8=CC=C(C=C8)[S](O)(=O)=O",8.594,4,1,10]
["S8961","Alobresib (GS-5829)","a2","L3900-33","in 10mM DMSO","Akt,Apoptosis related,Epigenetic Reader Domain,ERK,Myc,NF-κB","Epigenetics","Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Alobresib (GS-5829) inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. Alobresib (GS-5829) also inhibits NF-κB signaling.",437.49,"1637771-14-2",{"v":87,"d":"87.00"},198.86,"˂1","N/A","http://www.selleckchem.com/products/alobresib.html","C26H23N5O2","Free Base","N/A","CC1=C(C(=NO1)C)C2=CC(=C3N=C([NH]C3=C2)C4CC4)C(O)(C5=CC=CC=N5)C6=CC=CC=N6",3.767,5,1,5]
["S8969","Molnupiravir (EIDD-2801)","b2","L3900-33","in 10mM DMSO","COVID-19,SARS-CoV","Microbiology","Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.",329.31,"2349386-89-4",{"v":66,"d":"66.00"},200.42,{"v":20,"d":"20.00"},60.73,"http://www.selleckchem.com/products/eidd-2801.html","C13H19N3O7","Free Base","MK-4482","CC(C)C(=O)OCC1OC(C(O)C1O)N2C=C\\C(NC2=O)=N/O",-0.875,5,3,5]
["S8995","BAY 2416964","c2","L3900-33","in 10mM DMSO","AhR","Metabolism","BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.",387.82,"2242464-44-2",{"v":78,"d":"78.00"},201.12,"<1","N/A","http://www.selleckchem.com/products/bay-2416964.html","C18H18ClN5O3","Free Base","N/A","CC(CO)NC(=O)C1=CC(=NN(C1=O)C2=C[N](C)N=C2)C3=CC=C(Cl)C=C3",{"v":1.55,"d":"1.550"},4,2,5]
["S0018","Verdiperstat","d2","L3900-33","in 10mM DMSO","Peroxidases","Metabolism","Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.",253.32,"890655-80-8",{"v":51,"d":"51.00"},201.33,"<1","N/A","http://www.selleckchem.com/products/verdiperstat.html","C11H15N3O2S","free base","AZD-3241, BHV-3241","CC(C)OCCN1C(=S)NC(=O)C2=C1C=C[NH]2",{"v":2.27,"d":"2.270"},2,2,4]
["S0074","Relebactam","e2","L3900-33","in 10mM DMSO","β-lactamase","Immunology & Inflammation","Relebactam (MK-7655) is a potent inhibitor against KPC-2, class A and class C (AmpC) β-lactamases.",348.38,"1174018-99-5",{"v":70,"d":"70.00"},200.93,{"v":70,"d":"70.00"},200.93,"http://www.selleckchem.com/products/relebactam.html","C12H20N4O6S","free base","MK-7655","O[S](=O)(=O)ON1C2CCC(N(C2)C1=O)C(=O)NC3CCNCC3",-1.759,3,2,4]
["S0076","ABX464","f2","L3900-33","in 10mM DMSO","HIV","Microbiology","ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.",338.71,"1258453-75-6",{"v":68,"d":"68.00"},200.76,"<1","N/A","http://www.selleckchem.com/products/abx464.html","C16H10ClF3N2O","free base","SPL-464","FC(F)(F)OC1=CC=C(NC2=NC3=C(C=CC=C3Cl)C=C2)C=C1",6.889,2,1,4]
["S0085","BMS-813160","g2","L3900-33","in 10mM DMSO","CCR","Immunology & Inflammation","BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion.",484.64,"1286279-29-5",{"v":97,"d":"97.00"},200.15,"<1","N/A","http://www.selleckchem.com/products/bms813160.html","C25H40N8O2","free base","N/A","CC(=O)NC1CC(CCC1N2CCC(NC3=NC=NC4=CC(=N[N]34)C(C)(C)C)C2=O)NC(C)(C)C",1.774,5,3,7]
["S0088","Pemigatinib (INCB054828)","h2","L3900-33","in 10mM DMSO","FGFR","Angiogenesis","Pemigatinib (INCB054828, Pemazyre) is an orally active and selective inhibitor of FGFR with IC50 of 0.4 nM, 0.5 nM, 1.2 nM and 30 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.",{"v":487.5,"d":"487.50"},"1513857-77-6",{"v":40,"d":"40.00"},82.05,"<1","N/A","http://www.selleckchem.com/products/pemigatinib-incb054828.html","C24H27F2N5O4","free base","Pemazyre","CCN1C(=O)N(CC2=C1C3=C([NH]C(=C3)CN4CCOCC4)N=C2)C5=C(F)C(=CC(=C5F)OC)OC",2.596,5,1,6]
["S0135","JMS-17-2","a3","L3900-33","in 10mM DMSO","GPR","GPCR & G Protein","JMS-17-2 is a potent and selective small-molecule antagonist of CX3C chemokine receptor 1 (CX3CR1/GPR13) with IC50 of 0.32 nM. JMS-17-2 is used in the research of  metastatic disease in breast cancer patients.",419.95,"1380392-05-1",{"v":40,"d":"40.00"},95.25,"<1","N/A","http://www.selleckchem.com/products/jms-17-2.html","C25H26ClN3O","free base","N/A","ClC1=CC=C(C=C1)C2CCN(CCCN3C(=O)C4=CC=C[N]4C5=CC=CC=C35)CC2",5.224,1,0,5]
["S0188","GSK369796 Dihydrochloride","b3","L3900-33","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","GSK369796 Dihydrochloride (N-tert-butylisoquine) is an inhibitor of hERG potassium ion channel repolarization with IC50 of 7.5 μM. GSK369796 Dihydrochloride is an affordable and effective 4-aminoquinoline antimalarial.",428.78,"1010411-21-8",{"v":86,"d":"86.00"},200.57,{"v":40,"d":"40.00"},93.29,"http://www.selleckchem.com/products/gsk369796.html","C20H24Cl3N3O","Dihydrochloride","GSK369796, N-tert-butylisoquine","Cl.Cl.CC(C)(C)NCC1=C(O)C=C(NC2=CC=NC3=CC(=CC=C23)Cl)C=C1",5.221,1,3,5]
["S0194","Balicatib","c3","L3900-33","in 10mM DMSO","Cysteine Protease","Proteases","Balicatib (AAE-581) is a potent and selective inhibitor of the osteoclastic enzyme cathepsin K.",411.54,"354813-19-7",{"v":82,"d":"82.00"},199.25,"<1","N/A","http://www.selleckchem.com/products/balicatib.html","C23H33N5O2","free base","AAE-581","CCCN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3(CCCCC3)C(=O)NCC#N",2.748,2,2,7]
["S0278","SU5614","d3","L3900-33","in 10mM DMSO","Apoptosis related,c-Kit,FLT3,VEGFR","Protein Tyrosine Kinase","SU5614 (Chloro-SU5416, Chloro-Semaxanib) is a small molecule receptor tyrosine kinases (RTK) inhibitor of VEGFR-2, c-kit, and both wild-type and mutant FLT3. SU5614 reduces cell proliferation and induces apoptosis.",272.73,"1055412-47-9",{"v":10,"d":"10.00"},36.67,"<1","N/A","http://www.selleckchem.com/products/su5614.html","C15H13ClN2O","free base","Chloro-SU5416, Chloro-Semaxanib","CC1=CC(=C([NH]1)/C=C/2C(=O)NC3=CC=C(Cl)C=C23)C",3.412,1,2,1]
["S0314","TR-14035","e3","L3900-33","in 10mM DMSO","Integrin","Cytoskeletal Signaling","TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.",474.33,"232271-19-1",{"v":95,"d":"95.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/tr-14035.html","C24H21Cl2NO5","free base","SB 683698, MDK-1191","COC1=CC=CC(=C1C2=CC=C(CC(NC(=O)C3=C(Cl)C=CC=C3Cl)C(O)=O)C=C2)OC",5.374,4,1,8]
["S0325","Treprostinil sodium","f3","L3900-33","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.",412.49,"289480-64-4",{"v":82,"d":"82.00"},198.79,{"v":82,"d":"82.00"},198.79,"http://www.selleckchem.com/products/treprostinil-sodium.html","C23H33NaO5","sodium","UT-15, Remodulin, Orenitram, Tyvaso, Trevyent","CCCCCC(O)CCC1C(O)CC2CC3=C(OCC(=O)O[Na])C=CC=C3CC12",4.526,3,2,11]
["S0444","Indibulin","g3","L3900-33","in 10mM DMSO","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.",389.83,"204205-90-3",{"v":40,"d":"40.00"},102.61,"<1","N/A","http://www.selleckchem.com/products/Indibulin.html","C22H16ClN3O2","free base","ZIO 301, D 24851, Zybulin","ClC1=CC=C(C[N]2C=C(C(=O)C(=O)NC3=CC=NC=C3)C4=CC=CC=C24)C=C1",4.097,3,1,5]
["S0445","SC-43","h3","L3900-33","in 10mM DMSO","Apoptosis related,phosphatase,STAT","Metabolism","SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.",{"v":431.8,"d":"431.80"},"1400989-25-4",{"v":86,"d":"86.00"},199.17,"<1","N/A","http://www.selleckchem.com/products/sc-43.html","C21H13ClF3N3O2","free base","N/A","FC(F)(F)C1=CC(=CC=C1Cl)NC(=O)NC2=CC=CC(=C2)OC3=CC=C(C=C3)C#N",5.568,2,2,5]
["S0475","GC376","a4","L3900-33","in 10mM DMSO","3C-Like Protease","Proteases","GC376 is a 3CLpro (3C-like protease) inhibitor with IC50 of ~ 1.11 μM for the PEDV 3CLpro. GC376 is active against the 3CLpro of multiple coronaviruses, including SARS-CoV.",507.53,"1416992-39-6",{"v":100,"d":"100.00"},197.03,{"v":100,"d":"100.00"},197.03,"http://www.selleckchem.com/products/gc376-sodium.html","C21H30N3NaO8S","free base","N/A","[Na+].CC(C)CC(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC2CCNC2=O)C(O)[S]([O-])(=O)=O",-1.095,4,4,12]
["S0485","Hoechst 33342","b4","L3900-33","in 10mM DMSO","Dyes","Others","Hoechst 33342 (Pibenzimol, bisBenzimide H 33342, HOE 33342, HO342) is a membrane-permeant fluorescent stain that can stain live cells. Hoechst 33342 binds to adenine-thymine-rich regions of DNA in the minor groove.",452.55,"23491-52-3",{"v":10,"d":"10.00"},{"v":22.1,"d":"22.10"},{"v":90,"d":"90.00"},198.87,"http://www.selleckchem.com/products/hoechst-33342.html","C27H28N6O","free base","Pibenzimol, bisBenzimide H 33342, HOE 33342, HO342","CCOC1=CC=C(C=C1)C2=NC3=CC=C(C=C3[NH]2)C4=NC5=CC=C(C=C5[NH]4)N6CCN(C)CC6",5.163,3,2,5]
["S0507","CBL0137","c4","L3900-33","in 10mM DMSO","NF-κB,p53","NF-κB","CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.",336.43,"1197996-80-7",{"v":15,"d":"15.00"},44.59,"<1","N/A","http://www.selleckchem.com/products/cbl-0137.html","C21H24N2O2","free base","Curaxin-137, CBL-C137, CBLC137","CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",3.338,2,1,6]
["S0555","Adomeglivant","d4","L3900-33","in 10mM DMSO","Glucagon Receptor","GPCR & G Protein","Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.",555.63,"1488363-78-5",{"v":100,"d":"100.00"},179.98,"<1","N/A","http://www.selleckchem.com/products/ly2409021-adomeglivant.html","C32H36F3NO4","free base","LY2409021","CC1=C(C(=CC(=C1)OC(CCC(F)(F)F)C2=CC=C(C=C2)C(=O)NCCC(O)=O)C)C3=CC=C(C=C3)C(C)(C)C",7.839,3,1,12]
["S0707","Silmitasertib (CX-4945) sodium salt","e4","L3900-33","in 10mM DMSO","Casein Kinase","Metabolism","Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.",371.75,"1309357-15-0",{"v":74,"d":"74.00"},199.06,{"v":74,"d":"74.00"},199.06,"http://www.selleckchem.com/products/silmitasertib-sodium-salt.html","C19H11ClN3NaO2","sodium","CX-4945 sodium salt","[Na+].[O-]C(=O)C1=CC2=C(C=C1)C3=C(C=CN=C3)C(=N2)NC4=CC(=CC=C4)Cl",2.683,2,1,3]
["S0777","Isuzinaxib (APX-115 free base)","f4","L3900-33","in 10mM DMSO","CCR,Interleukins,NADPH-oxidase,TNF-alpha","Immunology & Inflammation","Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.",279.34,"1270084-92-8",{"v":56,"d":"56.00"},200.47,"<1","N/A","http://www.selleckchem.com/products/apx-115-free-base.html","C17H17N3O","free base","Ewha-18278 free base","CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3",2.994,2,1,4]
["S0785","Apilimod (STA-5326) mesylate","g4","L3900-33","in 10mM DMSO","Interleukins,PIKfyve","Immunology & Inflammation","Apilimod (STA-5326) mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.",{"v":610.7,"d":"610.70"},"870087-36-8",{"v":60,"d":"60.00"},98.25,{"v":100,"d":"100.00"},163.75,"http://www.selleckchem.com/products/apilimod-mesylate.html","C25H34N6O8S2","mesylate","STA-5326 mesylate","CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4.C[S](O)(=O)=O.C[S](O)(=O)=O",3.657,6,1,8]
["S0994","Ipragliflozin L-Proline","h4","L3900-33","in 10mM DMSO","SGLT","GPCR & G Protein","Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.",519.58,"951382-34-6",{"v":35,"d":"35.00"},67.36,"<1","N/A","http://www.selleckchem.com/products/ipragliflozin-l-proline.html","C26H30FNO7S","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=CC(=C(F)C=C2)CC3=CC4=CC=CC=C4S3.OC(=O)C5CCCN5",-0.493,2,5,5]
["S1001","Navitoclax (ABT-263)","a5","L3900-33","in 10mM DMSO","Bcl-2","Apoptosis","Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.",974.61,"923564-51-6",{"v":100,"d":"100.00"},102.61,"<1","N/A","http://www.selleckchem.com/products/ABT-263.html","C47H55ClF3N5O6S3","free base","N/A","CC1(C)CCC(=C(CN2CCN(CC2)C3=CC=C(C=C3)C(=O)N[S](=O)(=O)C4=CC(=C(NC(CCN5CCOCC5)CSC6=CC=CC=C6)C=C4)[S](=O)(=O)C(F)(F)F)C1)C7=CC=C(Cl)C=C7",10.495,6,2,17]
["S3226","Dehydroabietic acid","b5","L3900-33","in 10mM DMSO","Anti-infection,Src,Syk,TAK1","Immunology & Inflammation","Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.",300.44,"1740-19-8",{"v":100,"d":"100.00"},332.85,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/dehydroabietic-acid.html","C20H28O2","free base","DAA, DHAA","CC(C)C1=CC2=C(C=C1)C3(C)CCCC(C)(C3CC2)C(O)=O",5.389,1,0,2]
["S3273","Hypericin","c5","L3900-33","in 10mM DMSO","Hydroxylase,MAO,P450 (e.g. CYP17),PKC,Reverse Transcriptase,Telomerase","Metabolism","Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).",504.44,"548-04-9",{"v":100,"d":"100.00"},198.24,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hypericin.html","C30H16O8","free base","Hyp, HY","CC1=C2C3=C(C)C=C(O)C4=C3C5=C6C2=C(C(=C1)O)C(=O)C7=C6C(=C(O)C=C7O)C8=C(O)C=C(O)C(=C58)C4=O",{"v":5.04,"d":"5.040"},2,6,0]
["S3282","Rebaudioside M","d5","L3900-33","in 10mM DMSO","Others","Others","Rebaudioside M, isolated from Stevia rebaudiana Bertoni, is a natural non-caloric potential sweetener in food and beverage products.",1291.29,"1220616-44-3",{"v":100,"d":"100.00"},77.44,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/rebaudioside-m.html","C56H90O33","free base","N/A","CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(OC6OC(CO)C(O)C(O)C6O)C5OC7OC(CO)C(O)C(O)C7O)C(=O)OC8OC(CO)C(O)C(OC9OC(CO)C(O)C(O)C9O)C8OC%10OC(CO)C(O)C(O)C%10O",{"v":-6.97,"d":"-6.970"},13,20,19]
["S6630","Dimethylcurcumin (ASC-J9)","e5","L3900-33","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.",396.43,"52328-98-0",{"v":79,"d":"79.00"},199.28,"<1","N/A","http://www.selleckchem.com/products/dimethylcurcumin-asc-j9.html","C23H24O6","free base","Dimethyl curcumin, ASCJ 9, GO-Y025","COC1=CC=C(/C=C/C(O)=C/C(=O)/C=C/C2=CC=C(OC)C(=C2)OC)C=C1OC",4.024,5,1,9]
["S6664","Gefapixant","f5","L3900-33","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors, respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough.",{"v":353.4,"d":"353.40"},"1015787-98-0",{"v":71,"d":"71.00"},200.91,"<1","N/A","http://www.selleckchem.com/products/gefapixant.html","C14H19N5O4S","free base","AF-219, MK-7264, R1646,RG-1646,RO 4926219","COC1=CC(=C(OC2=CN=C(N)N=C2N)C=C1[S](N)(=O)=O)C(C)C",1.061,6,3,5]
["S6762","Bozitinib (PLB-1001)","g5","L3900-33","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.",424.38,"1440964-89-5",{"v":85,"d":"85.00"},200.29,"<1","N/A","http://www.selleckchem.com/products/bozitinib.html","C20H15F3N8","free base","CBT-101, APL-101, CBI-3103","C[N]1C=C2C=C(C(=CC2=N1)F)C(F)(F)C3=NN=C4C=CC(=N[N]34)C5=C[N](N=C5)C6CC6",3.548,5,0,4]
["S6803","1-BCP","h5","L3900-33","in 10mM DMSO","GluR","Neuronal Signaling","1-BCP (Piperonylic acid piperidide) is a memory-enhancing agent that enhances AMPA-induced currents.",233.26,"34023-62-6",{"v":47,"d":"47.00"},201.49,{"v":6,"d":"6.00"},25.72,"http://www.selleckchem.com/products/1-bcp.html","C13H15NO3","free base","Piperonylic acid piperidide","O=C(N1CCCCC1)C2=CC=C3OCOC3=C2",1.929,3,0,1]
["S6811","Miransertib (ARQ-092)","a6","L3900-33","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Miransertib (ARQ-092) is a potent, selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.",432.52,"1313881-70-7",{"v":8,"d":"8.00"},{"v":18.5,"d":"18.50"},"<1","N/A","http://www.selleckchem.com/products/miransertib.html","C27H24N6","free base","N/A","NC1=C(C=CC=N1)C2=NC3=C(N=C(C=C3)C4=CC=CC=C4)[N]2C5=CC=C(C=C5)C6(N)CCC6",4.598,3,2,4]
["S6852","Gossypol","b6","L3900-33","in 10mM DMSO","Apoptosis related,Bcl-2,Dehydrogenase","Apoptosis","Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.",518.55,"303-45-7",{"v":100,"d":"100.00"},192.85,"<1","N/A","http://www.selleckchem.com/products/gossypol.html","C30H30O8","free base","BL 193","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C)O",6.592,2,6,5]
["S6853","ONC206","c6","L3900-33","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","ONC206 is a selective antagonist of  DRD2/3/4 with broad-spectrum anti-tumor activity.",408.44,"1638178-87-6",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://www.selleckchem.com/products/onc206.html","C23H22F2N4O","free base","N/A","FC1=CC(=C(CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25)C=C1)F",3.137,2,0,4]
["S6854","Triazavirin","d6","L3900-33","in 10mM DMSO","DNA/RNA Synthesis,Influenza Virus,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.",{"v":286.2,"d":"286.20"},"928659-17-0",{"v":57,"d":"57.00"},199.16,{"v":20,"d":"20.00"},69.88,"http://www.selleckchem.com/products/triazavirin.html","C5H7N6NaO5S","free base","TZV, Riamilovir","O.O.[Na+].CSC1=NC2=NN=C(C(=O)N2[N-]1)[N+]([O-])=O",-0.184,4,0,2]
["S6870","Ningetinib","e6","L3900-33","in 10mM DMSO","Axl,c-Met,VEGFR","Protein Tyrosine Kinase","Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.",556.58,"1394820-69-9",{"v":20,"d":"20.00"},35.93,"<1","N/A","http://www.selleckchem.com/products/ningetinib.html","C31H29FN4O5","free base","CT-053, DE-120, CT053PTSA","CN1N(C(=O)C(=C1C)C(=O)NC2=CC(=C(OC3=C4C=CC(=CC4=NC=C3)OCC(C)(C)O)C=C2)F)C5=CC=CC=C5",3.942,5,1,8]
["S6888","SEL201","f6","L3900-33","in 10mM DMSO","MNK","MAPK","SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8  nM and 5.4 nM, respectively.",{"v":350.8,"d":"350.80"},"2095704-43-9",{"v":70,"d":"70.00"},199.54,"<1","N/A","http://www.selleckchem.com/products/sel201.html","C19H15ClN4O","free base","SLV-2436, SEL201-88","NC1=N[NH]C2=C1C=CC(=C2)C3=CN(CC4=CC(=CC=C4)Cl)C(=O)C=C3",3.044,2,2,3]
["S6896","Clascoterone","g6","L3900-33","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR).",402.52,"19608-29-8",{"v":80,"d":"80.00"},198.75,"<1","N/A","http://www.selleckchem.com/products/clascoterone.html","C24H34O5","free base","Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01","CCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C)C(=O)CO",3.498,4,1,5]
["S6910","Preladenant","h6","L3900-33","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Preladenant (Privadenant, SCH 420814, MK-3814) is a potent, competitive and selective antagonist of the human adenosine A2A receptor with Ki of 1.1 nM.",503.56,"377727-87-2",{"v":8,"d":"8.00"},15.89,"<1","N/A","http://www.selleckchem.com/products/preladenant.html","C25H29N9O3","free base","Privadenant, SCH 420814, MK-3814","COCCOC1=CC=C(C=C1)N2CCN(CC2)CC[N]3N=CC4=C3N=C(N)[N]5N=C(N=C45)C6=CC=CO6",2.456,7,1,9]
["S7394","MDL-28170","a7","L3900-33","in 10mM DMSO","Cysteine Protease","Proteases","MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase.",382.45,"88191-84-8",{"v":76,"d":"76.00"},198.72,"<1","N/A","http://www.selleckchem.com/products/mdl-28170.html","C22H26N2O4","free base","Calpain Inhibitor III","CC(C)C(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C=O",3.531,4,2,10]
["S8512","Cenicriviroc (TAK-652)","b7","L3900-33","in 10mM DMSO","CCR,HIV","Immunology & Inflammation","Cenicriviroc (CVC, TAK-652, TBR-652) is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.",696.94,"497223-25-3",{"v":100,"d":"100.00"},143.48,"<1","N/A","http://www.selleckchem.com/products/cenicriviroc.html","C41H52N4O4S","free base","CVC, TBR-652","CCCCOCCOC1=CC=C(C=C1)C2=CC=C3N(CCC\\C(=C/C3=C2)C(=O)NC4=CC=C(C=C4)[S](=O)CC5=CN=C[N]5CCC)CC(C)C",7.684,5,1,17]
["S8543","ARN-3236","c7","L3900-33","in 10mM DMSO","Apoptosis related,SIK","Immunology & Inflammation","ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.",336.41,"1613710-01-2",{"v":67,"d":"67.00"},199.16,"<1","N/A","http://www.selleckchem.com/products/arn-3236.html","C19H16N2O2S","free base","N/A","COC1=CC(=C(C=C1)C2=C[NH]C3=NC=CC(=C23)C4=CSC=C4)OC",3.837,3,1,4]
["S8574","BI 894999","d7","L3900-33","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BI 894999 is a potent and selective BET inhibitor with IC50 of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI 894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1.",429.51,"1660117-38-3",{"v":86,"d":"86.00"},200.23,"<1","N/A","http://www.selleckchem.com/products/bi894999.html","C25H27N5O2","free base","N/A","CC([N]1C2=CC(=NC=C2N=C1C3=NN(C)C(=O)C(=C3)C)C4CCOCC4)C5=CC=CC=C5",3.677,5,0,4]
["S8730","BAY 1251152","e7","L3900-33","in 10mM DMSO","CDK","Cell Cycle","BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.",404.43,"1610358-56-9",{"v":81,"d":"81.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/bay1251152.html","C19H18F2N4O2S","free base","(+)-BAY-1251152","COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)C[S](C)(=N)=O",4.677,4,1,6]
["S8845","GSK3145095","f7","L3900-33","in 10mM DMSO","RIP kinase","Apoptosis","GSK3145095 is a potent and orally active RIP1 kinase inhibitor with IC50 of 6.3 nM with potential antineoplastic and immunomodulatory activities.",397.38,"1622849-43-7",{"v":79,"d":"79.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://www.selleckchem.com/products/gsk3145095.html","C20H17F2N5O2","free base","N/A","FC1=CC2=C(NC(=O)C(CC2)NC(=O)C3=N[NH]C(=N3)CC4=CC=CC=C4)C(=C1)F",2.573,4,3,4]
["S8916","BI-3406","g7","L3900-33","in 10mM DMSO","Ras","Cell Cycle","BI-3406 (compound I-13) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 5 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhibits anti-tumor activities.",462.46,"2230836-55-0",{"v":92,"d":"92.00"},198.94,"<1","N/A","http://www.selleckchem.com/products/bi-3406.html","C23H25F3N4O3","free base","N/A","COC1=C(OC2CCOC2)C=C3C(=NC(=NC3=C1)C)NC(C)C4=CC(=CC(=C4)N)C(F)(F)F",3.594,5,2,7]
["S8975","Mezigdomide (CC-92480)","h7","L3900-33","in 10mM DMSO","E3 Ligase","Ubiquitin","Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.",567.61,"2259648-80-9",{"v":100,"d":"100.00"},176.18,"<1","N/A","http://www.selleckchem.com/products/cc-92480.html","C32H30FN5O4","free base","N/A","FC1=CC(=CC=C1N2CCN(CC2)CC3=CC=C(COC4=CC=CC5=C4CN(C6CCC(=O)NC6=O)C5=O)C=C3)C#N",3.586,4,1,7]
["S8978","Mitoquinone (MitoQ10) mesylate","a8","L3900-33","in 10mM DMSO","ROS","Immunology & Inflammation","Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.",678.81,"845959-50-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/mitoquinone-mesylate.html","C38H47O7PS","mesylate","MitoQ, Mitoubiquinone","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.C[S]([O-])(=O)=O",6.675,4,0,16]
["S8992","RBN012759","b8","L3900-33","in 10mM DMSO","PARP","DNA Damage/DNA Repair","RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.",378.46,"2360851-29-0",{"v":76,"d":"76.00"},200.81,"<1","N/A","http://www.selleckchem.com/products/rbn012759.html","C19H23FN2O3S","free base","N/A","OC1CCC(CC1)SCC2=NC3=CC(=CC(=C3C(=O)N2)F)OCC4CC4",2.941,3,2,6]
["S8997","680C91","c8","L3900-33","in 10mM DMSO","IDO/TDO","Metabolism","680C91 is a potent and selective inhibitor of TDO with Ki of 51 nM.",238.26,"163239-22-3",{"v":48,"d":"48.00"},201.46,"<1","N/A","http://www.selleckchem.com/products/680c91.html","C15H11FN2","free base","N/A","FC1=CC2=C(C=C1)C(=C[NH]2)\\C=C\\C3=CC=CN=C3",3.164,1,1,2]
["S9600","Orelabrutinib (ICP-022)","d8","L3900-33","in 10mM DMSO","BTK","Angiogenesis","Orelabrutinib (ICP-022) is a potent, orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). Orelabrutinib has potential antineoplastic activity.",427.49,"1655504-04-3",{"v":86,"d":"86.00"},201.17,"<1","N/A","http://www.selleckchem.com/products/orelabrutinib.html","C26H25N3O3","free base","ICP-022","NC(=O)C1=C(N=C(C=C1)C2CCN(CC2)C(=O)C=C)C3=CC=C(OC4=CC=CC=C4)C=C3",4.055,4,1,6]
["S9602","Elraglusib","e8","L3900-33","in 10mM DMSO","Apoptosis related,GSK-3","PI3K/Akt/mTOR","Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.",404.35,"1034895-42-5",{"v":81,"d":"81.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/9-ing-41.html","C22H13FN2O5","free base","9-ing-41","C[N]1C=C(C2=CC3=C(OCO3)C=C12)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(F)C=C6",3.339,5,1,2]
["S9604","IM156","f8","L3900-33","in 10mM DMSO","AMPK,Apoptosis related,OXPHOS","PI3K/Akt/mTOR","IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.",315.29,"1422365-93-2",{"v":63,"d":"63.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/im156.html","C13H16F3N5O","free base","HL156A","FC(F)(F)OC1=CC=C(NC(=N)NC(=N)N2CCCC2)C=C1",3.622,1,2,7]
["S9611","ABTL-0812","g8","L3900-33","in 10mM DMSO","Akt,Autophagy,mTOR,ROS","PI3K/Akt/mTOR","ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.",296.44,"57818-44-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/abtl-0812.html","C18H32O3","free base","α-Hydroxylinoleic acid","CCCCC\\C=C/C\\C=C/CCCCCCC(O)C(O)=O",5.629,1,1,14]
["S9621","Donafenib (Sorafenib D3)","h8","L3900-33","in 10mM DMSO","Raf,VEGFR","MAPK","Donafenib (Sorafenib D3, Bay 43-9006 D3, CM-4307) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B-RAF, respectively.",467.84,"1130115-44-4",{"v":94,"d":"94.00"},200.92,"<1","N/A","http://www.selleckchem.com/products/donafenib-sorafenib-d3.html","C21H13D3ClF3N4O3","free base","Bay 43-9006 D3, CM-4307","C(NC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)([2H])([2H])[2H]",4.175,4,3,7]
["S9634","Phenoxodiol (Haginin E)","a9","L3900-33","in 10mM DMSO","Apoptosis related,Caspase,IAP,Topoisomerase","Apoptosis","Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.",240.25,"81267-65-4",{"v":48,"d":"48.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/phenoxodiol.html","C15H12O3","free base","Idronoxil, Dehydroequol, NV 06, PXD","OC1=CC=C(C=C1)C2=CC3=CC=C(O)C=C3OC2",3.029,1,2,1]
["S9639","VX-803 (M4344)","b9","L3900-33","in 10mM DMSO","ATM/ATR,Chk","PI3K/Akt/mTOR","VX-803 (M4344, ATR inhibitor 2) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.",541.55,"1613191-99-3",{"v":15,"d":"15.00"},{"v":27.7,"d":"27.70"},"<1","N/A","http://www.selleckchem.com/products/vx803-m4344.html","C25H29F2N9O3","free base","ATR inhibitor 2","NC1=N[N]2C=C(F)C=NC2=C1C(=O)NC3=C(N4CCC(CC4)C(=O)N5CCN(CC5)C6COC6)C(=CN=C3)F",-0.338,6,2,5]
["S9641","Pibrentasvir (ABT-530)","c9","L3900-33","in 10mM DMSO","HCV Protease","Proteases","Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.",1113.18,"1353900-92-1",{"v":100,"d":"100.00"},89.83,"<1","N/A","http://www.selleckchem.com/products/pibrentasvir-abt-530-.html","C57H65F5N10O8","free base","N/A","COC(C)C(NC(=O)OC)C(=O)N1CCCC1C2=NC3=C([NH]2)C=C(C4CCC(N4C5=CC(=C(N6CCC(CC6)C7=CC=C(F)C=C7)C(=C5)F)F)C8=CC9=C(C=C8F)N=C([NH]9)C%10CCCN%10C(=O)C(NC(=O)OC)C(C)OC)C(=C3)F",8.515,10,4,17]
["S9648","NEO2734","d9","L3900-33","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.",435.44,"2081072-29-7",{"v":87,"d":"87.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/neo2734.html","C22H24F3N3O3","free base","EP31670","CN1C=C(C=C(C)C1=O)C2=CC=C3N=C(C4CCOCC4)[N](CCOC(F)(F)F)C3=C2",4.151,4,0,6]
["S9649","Acelarin (NUC-1031)","e9","L3900-33","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM.",580.47,"840506-29-8",{"v":100,"d":"100.00"},172.27,"<1","N/A","http://www.selleckchem.com/products/acelarin-nuc-1031.html","C25H27F2N4O8P","free base","CPF-31, MTL-007, GTPL7389","CC(N[P](=O)(OCC1OC(N2C=CC(=NC2=O)N)C(F)(F)C1O)OC3=CC=CC=C3)C(=O)OCC4=CC=CC=C4",{"v":1.69,"d":"1.690"},7,3,12]
["S9660","Remibrutinib (LOU064)","f9","L3900-33","in 10mM DMSO","BTK,Interleukins","Angiogenesis","Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.",507.53,"1787294-07-8",{"v":100,"d":"100.00"},197.03,"<1","N/A","http://www.selleckchem.com/products/remibrutinib-lou064.html","C27H27F2N5O3","free base","N/A","CN(CCOC1=C(N=CN=C1N)C2=C(C)C(=CC(=C2)F)NC(=O)C3=C(F)C=C(C=C3)C4CC4)C(=O)C=C",4.374,5,2,9]
["S0067","GS-444217","g9","L3900-33","in 10mM DMSO","ASK","Apoptosis","GS-444217 (ASK1-IN-1) is a potent, selective, orally available and ATP-competitive inhibitor of ASK1 (apoptosis signal-regulating kinase 1) with IC50 of 2.87 nM.",411.46,"1262041-49-5",{"v":60,"d":"60.00"},145.82,"<1","N/A","https://www.selleckchem.com/products/gs-444217.html","C23H21N7O","Free Base","ASK1-IN-1","O=C(NC1=CC=CC(=C1)C2=NN=C[N]2C3CC3)C4=NC=CC(=C4)[N]5C=NC(=C5)C6CC6",2.587,5,1,6]
["S0106","BD-1047 dihydrobromide","h9","L3900-33","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.",437.04,"138356-21-5",{"v":50,"d":"50.00"},114.41,{"v":87,"d":"87.00"},199.07,"https://www.selleckchem.com/products/bd-1047-dihydrobromide.html","C13H22Br2Cl2N2","Dihydrobromide","BD-1047 HBr","Br.Br.CN(C)CCN(C)CCC1=CC(=C(Cl)C=C1)Cl",4.674,0,0,6]
["S0110","APD597","a10","L3900-33","in 10mM DMSO","GPR,P450 (e.g. CYP17)","GPCR & G Protein","APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).",479.55,"897732-93-3",{"v":96,"d":"96.00"},200.19,"<1","N/A","https://www.selleckchem.com/products/apd597.html","C21H29N5O6S","Free Base","JNJ-38431055","COC1=C(NC2=C(C)N=C(C=C2)[S](C)(=O)=O)N=CN=C1OC3CCN(CC3)C(=O)OC(C)C",2.583,9,1,8]
["S0141","NQ301","b10","L3900-33","in 10mM DMSO","CD markers,Prostaglandin Receptor","Transmembrane Transporters","NQ301 (Compound 211), an antiplatelet and antithrombotic agent, is a selective CD45 inhibitor with IC50 of 200 nM. NQ301 inhibits thromboxane A2 receptor (TXA2) and synthase activity in rabbit platelets.",325.75,"130089-98-4",{"v":30,"d":"30.00"},{"v":92.1,"d":"92.10"},"<1","N/A","https://www.selleckchem.com/products/nq301.html","C18H12ClNO3","Free Base","N/A","CC(=O)C1=CC=C(NC2=C(Cl)C(=O)C3=CC=CC=C3C2=O)C=C1",2.955,3,1,3]
["S0165","Ampalex (CX-516)","c10","L3900-33","in 10mM DMSO","GluR","Neuronal Signaling","Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor. Ampalex exhibits potential treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).",241.29,"154235-83-3",{"v":48,"d":"48.00"},198.93,{"v":48,"d":"48.00"},198.93,"https://www.selleckchem.com/products/cx-516.html","C14H15N3O","Free Base","Ampakine CX 516, BDP-12, SPD 420","O=C(N1CCCCC1)C2=CC3=NC=CN=C3C=C2",1.625,3,0,1]
["S0196","Tirasemtiv (CK-2017357)","d10","L3900-33","in 10mM DMSO","Others","Others","Tirasemtiv (CK-2017357, CK-357) is a direct fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium.",230.27,"1005491-05-3",{"v":46,"d":"46.00"},199.77,"<1","N/A","https://www.selleckchem.com/products/tirasemtiv-ck-2017357.html","C12H14N4O","Free Base","CK-357","CCC(CC)N1C(=O)NC2=NC=C(N=C12)C#C",3.005,3,1,3]
["S0283","COH-29","e10","L3900-33","in 10mM DMSO","RNR","DNA Damage/DNA Repair","COH29 (RNR Inhibitor COH29) is a potent inhibitor of ribonucleotide reductase (RNR) with anticancer activity. COH29 (RNR Inhibitor COH29) inhibits recombinant RNR small subunit (RRM1/RRM2) activity in vitro with IC50 of 16 μM.",420.44,"1190932-38-7",{"v":40,"d":"40.00"},95.14,{"v":60,"d":"60.00"},142.71,"https://www.selleckchem.com/products/coh-29.html","C22H16N2O5S","Free Base","RNR Inhibitor COH29","OC1=C(O)C=C(C=C1)C(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC(=C(O)C=C4)O",{"v":4.4,"d":"4.400"},2,5,4]
["S0323","Antineoplaston A10","f10","L3900-33","in 10mM DMSO","Ras","Apoptosis","Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.",246.26,"91531-30-5",{"v":49,"d":"49.00"},198.98,"<1","N/A","https://www.selleckchem.com/products/antineoplaston-a10.html","C13H14N2O3","Free Base","N/A","O=C1CCC(NC(=O)CC2=CC=CC=C2)C(=O)N1",0.307,3,2,3]
["S0354","Alsterpaullone","g10","L3900-33","in 10mM DMSO","Apoptosis related,Caspase,CDK,GSK-3","Cell Cycle","Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.",293.28,"237430-03-4",{"v":25,"d":"25.00"},85.24,"<1","N/A","https://www.selleckchem.com/products/alsterpaullone.html","C16H11N3O3","Free Base","Alp, 9-Nitropaullone, NSC 705701","[O-][N+](=O)C1=CC2=C([NH]C3=C2CC(=O)NC4=CC=CC=C34)C=C1",2.817,1,2,1]
["S0467","Emodepside","h10","L3900-33","in 10mM DMSO","Parasite,Potassium Channel","Immunology & Inflammation","Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. Emodepside activates Ca-dependent SLO-1-like K channels.",1119.39,"155030-63-0",{"v":100,"d":"100.00"},89.33,"<1","N/A","https://www.selleckchem.com/products/qht06.html","C60H90N6O14","Free Base","QHT06, BAY 44-4400, PF 1022-221","CC(C)CC1N(C)C(=O)C(C)OC(=O)C(CC(C)C)N(C)C(=O)C(CC2=CC=C(C=C2)N3CCOCC3)OC(=O)C(CC(C)C)N(C)C(=O)C(C)OC(=O)C(CC(C)C)N(C)C(=O)C(CC4=CC=C(C=C4)N5CCOCC5)OC1=O",7.503,14,0,14]
["S0474","Avacopan (CCX168)","a11","L3900-33","in 10mM DMSO","CD markers","Immunology & Inflammation","Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.",581.64,"1346623-17-3",{"v":100,"d":"100.00"},171.93,"<1","N/A","https://www.selleckchem.com/products/avacopan-ccx168-.html","C33H35F4N3O2","Free Base","CCX168","CC1=C(C=C(NC(=O)C2CCCN(C2C3=CC=C(NC4CCCC4)C=C3)C(=O)C5=C(C)C=CC=C5F)C=C1)C(F)(F)F",7.579,2,2,7]
["S0486","Hoechst 34580","b11","L3900-33","in 10mM DMSO","Beta Amyloid,Dyes","Neuronal Signaling","Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye to stain DNA and nuclei. Hoechst 34580 is also a good candidate for treating the Alzheimer's disease by inhibiting amyloid beta (Aβ) formation with IC50 of 0.86 μM.",451.57,"23555-00-2",{"v":5,"d":"5.00"},11.07,{"v":90,"d":"90.00"},{"v":199.3,"d":"199.30"},"https://www.selleckchem.com/products/hoechst-34580.html","C27H29N7","Free Base","HOE 34580","CN1CCN(CC1)C2=CC3=C(C=C2)N=C([NH]3)C4=CC5=C(C=C4)N=C([NH]5)C6=CC=C(C=C6)N(C)C",4.992,2,2,4]
["S0495","BI-671800","c11","L3900-33","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.",{"v":501.5,"d":"501.50"},"1093108-50-9",{"v":100,"d":"100.00"},{"v":199.4,"d":"199.40"},"<1","N/A","https://www.selleckchem.com/products/ap-761-bi671800.html","C25H26F3N5O3","Free Base","AP-761, Cmpd A","CN(C)C1=NC(=NC(=C1CC(O)=O)N(C)C)CC2=CC=C(NC(=O)C3=CC=C(C=C3)C(F)(F)F)C=C2",{"v":4.5,"d":"4.500"},4,1,9]
["S0496","PF-04995274","d11","L3900-33","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.",432.51,"1331782-27-4",{"v":86,"d":"86.00"},198.84,"<1","N/A","https://www.selleckchem.com/products/pf-04995274.html","C23H32N2O6","Free Base","PF-4995274","OC1(CCOCC1)CN2CCC(CC2)COC3=NOC4=C3C(=CC=C4)OC5CCOC5",1.615,6,0,7]
["S0497","JNJ-42165279","e11","L3900-33","in 10mM DMSO","FAAH","Metabolism","JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.",{"v":410.8,"d":"410.80"},"1346528-50-4",{"v":82,"d":"82.00"},199.61,"<1","N/A","https://www.selleckchem.com/products/jnj-42165279.html","C18H17ClF2N4O3","Free Base","JNJ-5279","FC1(F)OC2=C(O1)C=C(CN3CCN(CC3)C(=O)NC4=C(Cl)C=CN=C4)C=C2",4.009,4,1,3]
["S0498","Namodenoson (CF-102)","f11","L3900-33","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.",544.73,"163042-96-4",{"v":100,"d":"100.00"},183.58,"<1","N/A","https://www.selleckchem.com/products/namodenoson-cf-102.html","C18H18ClIN6O4","Free Base","2-Cl-IB-MECA","CNC(=O)C1OC(C(O)C1O)[N]2C=NC3=C2N=C(Cl)N=C3NCC4=CC=CC(=C4)I",1.398,5,4,5]
["S0541","Dazoxiben hydrochloride","g11","L3900-33","in 10mM DMSO","P450 (e.g. CYP17),PGES,Prostaglandin Receptor","Metabolism","Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production.",{"v":268.7,"d":"268.70"},"74226-22-5",{"v":54,"d":"54.00"},200.97,{"v":54,"d":"54.00"},200.97,"https://www.selleckchem.com/products/dazoxiben.html","C12H13ClN2O3","Hydrochloride","Dazoxiben HCl","Cl.OC(=O)C1=CC=C(OCC[N]2C=CN=C2)C=C1",1.567,3,0,5]
["S0552","BNC210","h11","L3900-33","in 10mM DMSO","AChR","Neuronal Signaling","BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).",317.38,"13589-06-5",{"v":63,"d":"63.00"},{"v":198.5,"d":"198.50"},"<1","N/A","https://www.selleckchem.com/products/bnc210.html","C17H23N3O3","Free Base","H-Ile-Trp-OH, IW-2143","CCC(C)C(N)C(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(O)=O",-0.469,2,3,7]
["S0721","Ticlopidine","a2","L3900-34","in 10mM DMSO","Adenosine Receptor,P450 (e.g. CYP17)","Metabolism","Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina,PCR 5332) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). Ticlopidine is also an inhibitor of CYP2B6 with Ki of 0.2 μM.",263.79,"55142-85-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/ticlopidine.html","C14H14ClNS","Free Base","Yuclid, Ticlopidinum, Ticlopidina,PCR 5332","ClC1=CC=CC=C1CN2CCC3=C(C2)C=CS3",3.893,0,0,2]
["S0759","FPL 62064","b2","L3900-34","in 10mM DMSO","COX,Lipoxygenase","Metabolism","FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.",265.31,"103141-09-9",{"v":53,"d":"53.00"},199.77,"<1","N/A","https://www.selleckchem.com/products/fpl-62064.html","C16H15N3O","Free Base","N/A","COC1=CC=C(NC2=N[N](C=C2)C3=CC=CC=C3)C=C1",4.129,2,1,4]
["S0772","L-732138","c2","L3900-34","in 10mM DMSO","Neurokinin Receptor","GPCR & G Protein","L-732138 (L-732,138) is a selective, potent and competitive antagonist of neurokinin-1 (NK-1) receptor/substance P (SP) receptor. L-732138 inhibits the binding of 125I-SP to the human NK-1 receptor stably expressed in CHO cells with IC50 of 2.3 nM.",472.38,"148451-96-1",{"v":94,"d":"94.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/l-732138.html","C22H18F6N2O3","Free Base","L-732,138","CC(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)OCC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F",4.882,3,2,9]
["S0795","O-304","d2","L3900-34","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","O-304 (O-304X) is an orally available pan-activator of AMPK activated protein kinase (AMPK). O-304 (O-304X) exhibits a great potential as a novel drug to treat type 2 diabetes (T2D) and associated cardiovascular complications.",380.25,"1261289-04-6",{"v":20,"d":"20.00"},{"v":52.6,"d":"52.60"},"<1","N/A","https://www.selleckchem.com/products/o-304.html","C16H11Cl2N3O2S","Free Base","O-304X","ClC1=CC=C(CN2SC(=NC2=O)NC(=O)C3=CC=C(Cl)C=C3)C=C1",4.977,3,1,4]
["S0870","Barnidipine","e2","L3900-34","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites.",491.54,"104713-75-9",{"v":98,"d":"98.00"},199.37,"<1","N/A","https://www.selleckchem.com/products/barnidipine.html","C27H29N3O6","Free Base","Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca","COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC3CCN(C3)CC4=CC=CC=C4)C",3.398,4,1,9]
["S1198","Irinotecan (CPT-11)","f2","L3900-34","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11, (+)-Irinotecan) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.",586.68,"97682-44-5",{"v":51,"d":"51.00"},86.93,"<1","N/A","https://www.selleckchem.com/products/Irinotecan-cpt-11.html","C33H38N4O6","Free Base","(+)-Irinotecan,CPT-11","CCC1=C2C=C(OC(=O)N3CCC(CC3)N4CCCCC4)C=CC2=NC5=C1CN6C(=O)C7=C(C=C56)C(O)(CC)C(=O)OC7",3.686,6,0,5]
["S1272","XL228","g2","L3900-34","in 10mM DMSO","Aurora Kinase,Bcr-Abl,IGF-1R,Src","Angiogenesis","XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively.",437.54,"898280-07-4",{"v":88,"d":"88.00"},201.12,"<1","N/A","https://www.selleckchem.com/products/xl228.html","C22H31N9O","Free Base","N/A","CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)N3CCN(C)CC3)NC4=N[NH]C(=C4)C5CC5",4.542,5,3,8]
["S1313","GSK3117391","h2","L3900-34","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","GSK3117391 (GSK3117391A, HDAC-IN-3) is a potent histone deacetylase (HDAC) inhibitor.",403.52,"1018673-42-1",{"v":81,"d":"81.00"},200.73,"<1","N/A","https://www.selleckchem.com/products/gsk3117391.html","C22H33N3O4","Free Base","GSK3117391A, HDAC-IN-3","ONC(=O)CCC1=NC=C(CNC(C2CCCCC2)C(=O)OC3CCCC3)C=C1",3.163,4,2,10]
["S1421","Staurosporine (AM-2282)","a3","L3900-34","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,CaMK,PKA,PKC,PKG,S6 Kinase","TGF-beta/Smad","Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.",466.53,"62996-74-1",{"v":93,"d":"93.00"},199.34,"<1","N/A","https://www.selleckchem.com/products/Staurosporine.html","C28H26N4O3","Free Base","Antibiotic AM-2282, STS","CNC1CC2OC(C)(C1OC)[N]3C4=C(C=CC=C4)C5=C6CNC(=O)C6=C7C8=CC=CC=C8[N]2C7=C35",3.819,3,2,2]
["S2962","NP-G2-044","b3","L3900-34","in 10mM DMSO","Fascin","Stem Cells & Wnt","NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.",399.37,"1807454-59-6",{"v":80,"d":"80.00"},200.32,"<1","N/A","https://www.selleckchem.com/products/np-g2-044.html","C21H16F3N3O2","Free Base","N/A","CC1=C(C=CO1)C(=O)NC2=N[N](CC3=CC=C(C=C3)C(F)(F)F)C4=CC=CC=C24",4.778,3,1,5]
["S3069","Deoxycholic acid sodium salt","c3","L3900-34","in 10mM DMSO","GPCR19","GPCR & G Protein","Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.",414.55,"302-95-4",{"v":83,"d":"83.00"},200.22,{"v":83,"d":"83.00"},200.22,"https://www.selleckchem.com/products/deoxycholic-acid-sodium-salt.html","C24H39NaO4","Sodium salt","Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA","[Na+].CC(CCC([O-])=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C",2.608,0,2,4]
["S3109","N-Acetyl-L-leucine","d3","L3900-34","in 10mM DMSO","Others","Others","N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.",173.21,"1188-21-2",{"v":35,"d":"35.00"},202.07,"<1","N/A","https://www.selleckchem.com/products/n-acetyl-l-leucine.html","C8H15NO3","Free Base","N/A","CC(C)CC(NC(C)=O)C(O)=O",0.571,2,1,4]
["S3111","Pyridoxal hydrochloride","e3","L3900-34","in 10mM DMSO","Others","Others","Pyridoxal hydrochloride (HQ) is an active endogenous metabolite.",203.62,"65-22-5",{"v":40,"d":"40.00"},196.44,{"v":40,"d":"40.00"},196.44,"https://www.selleckchem.com/products/pyridoxal-hydrochloride.html","C8H10ClNO3","Free Base","HQ","Cl.CC1=NC=C(CO)C(=C1O)C=O",0.256,2,2,2]
["S3341","Palmitoleic acid","f3","L3900-34","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Palmitoleic acid (POA, Palmitoleate) stimulates the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPARα.",254.41,"373-49-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/palmitoleic-acid.html","C16H30O2","Free Base","POA, Palmitoleate","CCCCCC\\C=C/CCCCCCCC(O)=O",5.948,1,0,13]
["S4417","Ceftaroline Fosamil","g3","L3900-34","in 10mM DMSO","Anti-infection","Immunology & Inflammation","Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).",744.74,"400827-46-5",{"v":73,"d":"73.00"},98.02,"<1","N/A","https://www.selleckchem.com/products/ceftaroline-fosamil.html","C24H25N8O10PS4","Free Base","CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo","CCO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)SC3=NC(=CS3)C4=CC=[N+](C)C=C4)C5=NSC(=N5)N[P](O)(O)=O.CC([O-])=O",-0.454,8,2,11]
["S5248","Apatinib","h3","L3900-34","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,c-RET,Src,VEGFR","Protein Tyrosine Kinase","Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis.",397.47,"811803-05-1",{"v":79,"d":"79.00"},198.76,"<1","N/A","https://www.selleckchem.com/products/apatinib.html","C24H23N5O","Free Base","Rivoceranib, YN968D1","O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=C(NCC4=CC=NC=C4)N=CC=C3",3.578,3,2,6]
["S5645","Hemin","a4","L3900-34","in 10mM DMSO","Heme Oxygenase","Apoptosis","Hemin (protohemin) is an iron-containing porphyrin used in the management of porphyria attacks, particularly in acute intermittent porphyria.Hemin is an Heme oxygenase (HO)-1 inducer.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!",651.94,"16009-13-5",{"v":20,"d":"20.00"},30.68,"<1","N/A","https://www.selleckchem.com/products/hemin.html","C34H32ClFeN4O4","Free Base","protohemin","CC1=C(CCC(O)=O)C\\2=N\\C1=C/C3=C(C=C)C(=C4\\C=C5/N=C(/C=C6\\N([Fe](Cl)[N]34)\\C(=C2)C(=C6C)CCC(O)=O)C(=C5C=C)C)C",6.404,4,0,8]
["S6907","Rapastinel (GLYX-13)","b4","L3900-34","in 10mM DMSO","NMDAR","Neuronal Signaling","Rapastinel (GLYX-13, BV-102, TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site. Rapastinel has long-lasting antidepressant effects.",413.47,"117928-94-6",{"v":83,"d":"83.00"},200.74,{"v":83,"d":"83.00"},200.74,"https://www.selleckchem.com/products/rapastinel.html","C18H31N5O6","Free Base","BV-102, TPPT-amide","CC(O)C(N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NC(C(C)O)C(N)=O",-3.063,4,5,7]
["S6920","SEA0400","c4","L3900-34","in 10mM DMSO","Calcium Channel,ERK,NCX,p38 MAPK,ROS,Sodium Channel","Transmembrane Transporters","SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca(2+)-dependent manner.",371.38,"223104-29-8",{"v":74,"d":"74.00"},199.26,"<1","N/A","https://www.selleckchem.com/products/sea0400.html","C21H19F2NO3","Free Base","N/A","CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(=C3)F)C=C2)C(=C1)N",4.954,3,1,7]
["S6921","Dorzagliatin","d4","L3900-34","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.",462.93,"1191995-00-2",{"v":92,"d":"92.00"},198.73,"<1","N/A","https://www.selleckchem.com/products/dorzagliatin.html","C22H27ClN4O5","Free Base","HMS-5552, RO-5305552, Sinogliatin","CC(C)CC(N1CC(=CC1=O)OC2=CC=CC=C2Cl)C(=O)NC3=N[N](CC(O)CO)C=C3",2.366,4,3,10]
["S6948","Lanreotide","e4","L3900-34","in 10mM DMSO","GHSR","Endocrinology & Hormones","Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum), an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.",1096.32,"108736-35-2",{"v":100,"d":"100.00"},91.21,{"v":100,"d":"100.00"},91.21,"https://www.selleckchem.com/products/lanreotide.html","C54H69N11O10S2","Free Base","Laromustine, Angiopeptin, BIM 23014, BIM 23014C, BM 23014, Dermopeptin, Ipstyl, ITM-014, ITM-014T, Somatulina, Somatuline, Lanreotidum","CC(C)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(C(C)O)C(N)=O)NC(=O)C(N)CC5=CC6=CC=CC=C6C=C5",1.704,8,13,17]
["S6958","Treosulfan","f4","L3900-34","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.",{"v":278.3,"d":"278.30"},"299-75-2",{"v":56,"d":"56.00"},201.22,{"v":56,"d":"56.00"},201.22,"https://www.selleckchem.com/products/treosulfan.html","C6H14O8S2","Free Base","NSC 39069, Treosulphan","C[S](=O)(=O)OCC(O)C(O)CO[S](C)(=O)=O",-1.953,2,2,7]
["S6959","Perhexiline maleate","g4","L3900-34","in 10mM DMSO","CPT","Metabolism","Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1) with IC50s of 77 μM and 148 μM for rat heart CPT1 and liver CPT1, respectively, and also inhibits carnitine palmitoyltransferase 2 (CPT2).",393.56,"6724-53-4",{"v":78,"d":"78.00"},198.19,"<1","N/A","https://www.selleckchem.com/products/perhexiline-maleate.html","C23H39NO4","Maleate","N/A","OC(=O)\\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3",3.054,2,1,6]
["S6963","APTO-253","h4","L3900-34","in 10mM DMSO","Apoptosis related,KLF,Myc,p21","Cell Cycle","APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Kr&uuml;ppel-like factor 4).",367.38,"916151-99-0",{"v":73,"d":"73.00"},{"v":198.7,"d":"198.70"},"<1","N/A","https://www.selleckchem.com/products/apto-253.html","C22H14FN5","Free Base","LOR-253, LT-253","CC1=C(C2=NC3=C([NH]2)C4=CC=CN=C4C5=C3C=CC=N5)C6=C([NH]1)C=CC(=C6)F",4.287,3,2,1]
["S8919","LY-3381916","a5","L3900-34","in 10mM DMSO","IDO/TDO","Metabolism","LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. LY-3381916 exhibits anti-tumor activity.",396.45,"2166616-75-5",{"v":79,"d":"79.00"},199.27,"<1","N/A","https://www.selleckchem.com/products/ly-3381916.html","C23H25FN2O3","Free Base","IDO1-IN-5","CC(NC(=O)C1=CC=C(F)C=C1)C2=CC=C3N(CCC3=C2)C(=O)C4CCOCC4",2.962,3,1,4]
["S8957","Navoximod","b5","L3900-34","in 10mM DMSO","IDO/TDO","Metabolism","Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.",316.37,"1402837-78-8",{"v":63,"d":"63.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/navoximod.html","C18H21FN2O2","Free Base","GDC-0919, NLG-919","OC1CCC(CC1)C(O)CC2[N]3C=NC=C3C4=C2C(=CC=C4)F",2.224,1,2,3]
["S8993","Atamparib (RBN-2397)","c5","L3900-34","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Atamparib (RBN-2397) is a potent, selective and orally active NAD+ competitive inhibitor PARP7 with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment.",523.43,"2381037-82-5",{"v":100,"d":"100.00"},191.05,"<1","N/A","https://www.selleckchem.com/products/rbn-2397.html","C20H23F6N7O3","Free Base","N/A","CC(COCCC(=O)N1CCN(CC1)C2=NC=C(C=N2)C(F)(F)F)NC3=C(C(=O)NN=C3)C(F)(F)F",0.907,6,2,10]
["S9296","Fraxin","d5","L3900-34","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis.",370.31,"524-30-1",{"v":74,"d":"74.00"},199.83,{"v":6,"d":"6.00"},{"v":16.2,"d":"16.20"},"https://www.selleckchem.com/products/fraxin.html","C16H18O10","Free Base","Fraxetin-8-O-glucoside","COC1=CC2=C(OC(=O)C=C2)C(=C1O)OC3OC(CO)C(O)C(O)C3O",-0.531,5,5,4]
["S9521","Pentostatin","e5","L3900-34","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Pentostatin(CI-825,Deoxycoformycin) is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.",268.27,"53910-25-1",{"v":54,"d":"54.00"},201.29,{"v":54,"d":"54.00"},201.29,"https://www.selleckchem.com/products/pentostatin.html","C11H16N4O4","Free Base","CI-825,Deoxycoformycin","OCC1OC(CC1O)[N]2C=NC3=C2NC=NCC3O",-1.965,3,4,2]
["S9656","Enarodustat (JTZ-951)","f5","L3900-34","in 10mM DMSO","HIF","Angiogenesis","Enarodustat (JTZ-951) is a potent and orally active HIF prolyl hydroxylase inhibitor with IC50 of 0.22 μM for PHD2 and EC50 of 5.7 μM for EPO release from Hep3B cells. Enarodustat has the potential for the treatment of renal anemia.",340.33,"1262132-81-9",{"v":68,"d":"68.00"},199.81,"<1","N/A","https://www.selleckchem.com/products/enarodustat.html","C17H16N4O4","Free Base","N/A","OC(=O)CNC(=O)C1=C(O)C=C(CCC2=CC=CC=C2)[N]3N=CN=C13",1.511,4,2,6]
["S9674","Saroglitazar","g5","L3900-34","in 10mM DMSO","PPAR","Metabolism","Saroglitazar (Lipaglyn, ZYH1) is an agonist of peroxisome proliferator-activated receptor (PPAR) with EC50 of 0.65 pM and 3 nM for hPPARα and hPPARγ in HepG2 cells, respectively.",439.57,"495399-09-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","https://www.selleckchem.com/products/saroglitazar.html","C25H29NO4S","Free Base","Lipaglyn, ZYH1","CCOC(CC1=CC=C(OCC[N]2C(=CC=C2C3=CC=C(SC)C=C3)C)C=C1)C(O)=O",5.349,3,0,11]
["S9686","NBQX (FG9202)","h5","L3900-34","in 10mM DMSO","GluR","Neuronal Signaling","NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.",336.28,"118876-58-7",{"v":67,"d":"67.00"},199.24,"<1","N/A","https://www.selleckchem.com/products/nbqx.html","C12H8N4O6S","Free Base","NNC 079202","N[S](=O)(=O)C1=C2C(=CC=C1)C3=C(NC(=O)C(=O)N3)C=C2[N+]([O-])=O",-0.441,4,3,2]
["S9698","Ezatiostat","a6","L3900-34","in 10mM DMSO","Apoptosis related,ERK,JNK,Transferase","Metabolism","Ezatiostat (TER199, TLK199, Telintra), a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1). Ezatiostat activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis.",643.67,"168682-53-9",{"v":100,"d":"100.00"},155.36,"<1","N/A","https://www.selleckchem.com/products/ezatiostat.html","C29H36F3N3O8S","Free Base","TER199, TLK199, Telintra","CCOC(=O)C(N)CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C(=O)OCC)C2=CC=CC=C2.OC(=O)C(F)(F)F",0.745,7,3,18]
["S9699","Desidustat","b6","L3900-34","in 10mM DMSO","HIF","Angiogenesis","Desidustat (ZYAN1, ZYAN1-1001), an antianaemic drug candidate, is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis.",332.31,"1616690-16-4",{"v":12,"d":"12.00"},36.11,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/desidustat.html","C16H16N2O6","Free Base","ZYAN1, ZYAN1-1001","OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2N(OCC3CC3)C1=O",0.236,4,2,6]
["S9700","Tapinarof","c6","L3900-34","in 10mM DMSO","AhR,Apoptosis related","Metabolism","Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Tapinarof induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM.",254.32,"79338-84-4",{"v":51,"d":"51.00"},200.53,"<1","N/A","https://www.selleckchem.com/products/tapinarof.html","C17H18O2","Free Base","GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505","CC(C)C1=C(O)C=C(\\C=C\\C2=CC=CC=C2)C=C1O",4.526,0,2,3]
["S9703","IACS-13909","d6","L3900-34","in 10mM DMSO","phosphatase","Metabolism","IACS-13909  is a specific and potent allosteric inhibitor of SHP2 (Src homology 2 domain-containing phosphatase) that suppresses signaling through the MAPK pathway.",377.27,"2160546-07-4",{"v":75,"d":"75.00"},{"v":198.8,"d":"198.80"},"<1","N/A","https://www.selleckchem.com/products/iacs-13909.html","C17H18Cl2N6","Free Base","BBP-398","CC1(N)CCN(CC1)C2=CN=C3C(=N2)[NH]N=C3C4=CC=CC(=C4Cl)Cl",3.125,3,2,2]
["S9709","Muramyl dipeptide","e6","L3900-34","in 10mM DMSO","RUNX","Cell Cycle","Muramyl dipeptide (MDP) is a shared structural unit of peptidoglycans. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2.",492.48,"53678-77-6",{"v":98,"d":"98.00"},198.99,{"v":98,"d":"98.00"},198.99,"https://www.selleckchem.com/products/muramyl-dipeptide.html","C19H32N4O11","Free Base","MDP","CC(NC(=O)C(C)OC1C(O)C(CO)OC(O)C1NC(C)=O)C(=O)NC(CCC(O)=O)C(N)=O",-4.245,7,6,12]
["S9712","Fluzoparib (SHR-3162)","f6","L3900-34","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity, with an IC50 of 1.46±0.72 nM for PARP1.",{"v":472.4,"d":"472.40"},"1358715-18-0",{"v":94,"d":"94.00"},198.98,"<1","N/A","https://www.selleckchem.com/products/fluzoparib.html","C22H16F4N6O2","Free Base","HS10160","FC1=CC=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1C(=O)N4CC[N]5N=C(N=C5C4)C(F)(F)F",2.757,5,1,4]
["S9714","TVB-2640","g6","L3900-34","in 10mM DMSO","Fatty Acid Synthase","Metabolism","TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.",439.55,"1399177-37-7",{"v":88,"d":"88.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/tvb-2640.html","C27H29N5O","Free Base","ASC-40, FASN-IN-2, Denifanstat","CC1=NN=C([NH]1)C2=C(C=C(C)C(=C2)C(=O)N3CCC(CC3)C4=CC=C(C=C4)C#N)C5CCC5",4.638,3,1,4]
["S9718","TK216","h6","L3900-34","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.",376.23,"1903783-48-1",{"v":75,"d":"75.00"},199.35,"<1","N/A","https://www.selleckchem.com/products/tk216.html","C19H15Cl2NO3","Free Base","ONCT 216, SPH-8216","OC1(CC(=O)C2=CC=C(C=C2)C3CC3)C(=O)NC4=C(Cl)C=CC(=C14)Cl",3.785,2,1,4]
["S9719","CB-103","a7","L3900-34","in 10mM DMSO","Notch","Neuronal Signaling","CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.",242.32,"218457-67-1",{"v":48,"d":"48.00"},198.09,"<1","N/A","https://www.selleckchem.com/products/cb-103.html","C15H18N2O","Free Base","N/A","CC(C)(C)C1=CC=C(OC2=CC=C(N)C=N2)C=C1",3.432,2,1,3]
["S0032","Batefenterol","b7","L3900-34","in 10mM DMSO","AChR,Adrenergic Receptor","Neuronal Signaling","Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.",740.24,"743461-65-6",{"v":100,"d":"100.00"},135.09,"<1","N/A","http://www.selleckchem.com/products/batefenterol.html","C40H42ClN5O7","Free Base","GSK961081, TD-5959","COC1=CC(=C(Cl)C=C1CNCC(O)C2=CC=C(O)C3=C2C=CC(=O)N3)NC(=O)CCN4CCC(CC4)OC(=O)NC5=C(C=CC=C5)C6=CC=CC=C6",4.546,5,6,14]
["S0124","CGP71683 hydrochloride","c7","L3900-34","in 10mM DMSO","NPY receptor,NPY receptor","GPCR & G Protein","CGP71683 hydrochloride (CGP71683A) is a competitive and sellective neuropeptide Y receptor type 5 (Y5 receptor) antagonist with Ki of 1.3 nM.",512.07,"192322-50-2",{"v":100,"d":"100.00"},195.29,"<1","N/A","http://www.selleckchem.com/products/cgp71683hcl.html","C26H30ClN5O2S","Hydrochloride","CGP71683A, CGP71683 HCL","Cl.NC1=NC(=NC2=CC=CC=C12)NCC3CCC(CC3)CN[S](=O)(=O)C4=CC=CC5=CC=CC=C45",5.182,4,3,7]
["S0711","Canertinib dihydrochloride","d7","L3900-34","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR and ErbB2 autophosphorylation with IC50 of 7.4 nM and 9 nM, respectively.",558.86,"289499-45-2",{"v":100,"d":"100.00"},178.94,{"v":20,"d":"20.00"},35.79,"http://www.selleckchem.com/products/canertinib-dihydrochloride.html","C24H27Cl3FN5O3","Dihydrochloride","CI-1033 dihydrochloride, PD-183805 dihydrochloride","Cl.Cl.FC1=C(Cl)C=C(NC2=NC=NC3=CC(=C(NC(=O)C=C)C=C23)OCCCN4CCOCC4)C=C1",4.801,5,2,9]
["S0717","Varenicline (CP 526555) dihydrochloride","e7","L3900-34","in 10mM DMSO","AChR","Neuronal Signaling","Varenicline (CP 526555, Chantix, Champix,CP 526555 dihydrochloride) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.",284.18,"866823-63-4",{"v":57,"d":"57.00"},200.58,{"v":57,"d":"57.00"},200.58,"http://www.selleckchem.com/products/varenicline-dihydrochloride.html","C13H15Cl2N3","Dihydrochloride","Chantix, Champix,CP 526555 dihydrochloride","Cl.Cl.C1NCC2CC1C3=CC4=NC=CN=C4C=C23",1.802,2,1,0]
["S0820","RP-64477","f7","L3900-34","in 10mM DMSO","Acyltransferase","Metabolism","RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.",498.72,"135239-65-5",{"v":100,"d":"100.00"},200.51,"<1","N/A","http://www.selleckchem.com/products/rp-64477.html","C29H42N2O3S","Free Base","N/A","CCCCCCCCCCOC1=CC=C(C=C1)C(=O)NC2=CC(=CC=C2SC)C(=O)NCCCC",7.742,3,2,17]
["S0821","Pamicogrel","g7","L3900-34","in 10mM DMSO","COX","Immunology & Inflammation","Pamicogrel (KBT3022) is an inhibitor of cyclooxygenase (COX) with platelet anti-aggregatory properties.",448.53,"101001-34-7",{"v":45,"d":"45.00"},100.33,"<1","N/A","https://www.selleckchem.com/products/pamicogrel.html","C25H24N2O4S","Free Base","KBT3022","CCOC(=O)C[N]1C=CC=C1C2=NC(=C(S2)C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4",5.581,5,0,9]
["S0995","BioE-1115","h7","L3900-34","in 10mM DMSO","Casein Kinase,Serine/threonin kinase","Metabolism","BioE-1115 is a highly selective and potent dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α) with IC50 of ~4 nM and ~10 μM, respectively.",339.36,"1268863-35-9",{"v":68,"d":"68.00"},200.38,"<1","N/A","http://www.selleckchem.com/products/bioe-1115.html","C19H18FN3O2","Free Base","N/A","CC(C)N(C)C1=NC2=CC(=CC=C2N=C1C3=CC=C(F)C=C3)C(O)=O",4.504,3,0,4]
["S1997","Liranaftate","a8","L3900-34","in 10mM DMSO","Fungal","Microbiology","Liranaftate (M-732,Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities.",328.43,"88678-31-3",{"v":25,"d":"25.00"},76.12,"<1","N/A","http://www.selleckchem.com/products/liranaftate.html","C18H20N2O2S","Free Base","M-732,Piritetrate","COC1=NC(=CC=C1)N(C)C(=S)OC2=CC3=C(CCCC3)C=C2",6.319,3,0,5]
["S2945","SCH-442416","b8","L3900-34","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.",389.41,"316173-57-6",{"v":78,"d":"78.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://www.selleckchem.com/products/sch-442416.html","C20H19N7O2","Free Base","N/A","COC1=CC=C(CCC[N]2N=CC3=C2N=C(N)[N]4N=C(N=C34)C5=CC=CO5)C=C1",{"v":3.18,"d":"3.180"},6,1,6]
["S2959","LY255283","c8","L3900-34","in 10mM DMSO","LTR","Immunology & Inflammation","LY255283 is an antagonist of leukotriene B4 (LTB4) receptor (BLT2) that displaces [3H]LTB4 from its binding site on lung membranes with pKi of 7.0.",360.45,"117690-79-6",{"v":72,"d":"72.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/ly255283.html","C19H28N4O3","Free Base","N/A","CCC1=CC(=C(O)C=C1OCCCCCC(C)(C)C2=N[NH]N=N2)C(C)=O",4.392,5,2,10]
["S3380","Tecovirimat","d8","L3900-34","in 10mM DMSO","Antiviral","Immunology & Inflammation","Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.",376.33,"869572-92-9",{"v":75,"d":"75.00"},199.29,"<1","N/A","http://www.selleckchem.com/products/tecovirimat.html","C19H15F3N2O3","Free Base","Arestvyr, SIGA-246, ST-246, TPOXX","FC(F)(F)C1=CC=C(C=C1)C(=O)NN2C(=O)C3C4C=CC(C5CC45)C3C2=O",2.018,3,1,3]
["S3472","Metarrestin (ML246)","e8","L3900-34","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.",{"v":474.6,"d":"474.60"},"1443414-10-5",{"v":21,"d":"21.00"},44.25,"<1","N/A","http://www.selleckchem.com/products/metarrestin.html","C31H30N4O","Free Base","N/A","OC1CCC(CC1)N2C=NC3=C(C2=N)C(=C([N]3CC4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CC=C6",5.968,1,1,5]
["S3496","Lefamulin acetate (Xenleta)","f8","L3900-34","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Immunology & Inflammation","Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.",567.78,"1350636-82-6",{"v":100,"d":"100.00"},176.12,{"v":100,"d":"100.00"},176.12,"http://www.selleckchem.com/products/lefamulin-acetate.html","C30H49NO7S","Free Base","BC-3781 acetate","CC1CCC23CCC(=O)C2C1(C)C(CC(C)(C=C)C(O)C3C)OC(=O)CSC4CCC(N)CC4O.CC(O)=O",0.083,4,3,6]
["S3501","Perflubron","g8","L3900-34","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties.",498.96,"423-55-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/perflubron.html","C8BrF17","Free Base","1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB","FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br",5.546,0,0,7]
["S3565","Brequinar Sodium","h8","L3900-34","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.",397.35,"96201-88-6",{"v":79,"d":"79.00"},198.82,{"v":26,"d":"26.00"},65.43,"http://www.selleckchem.com/products/bipenquinate.html","C23H14F2NNaO2","Sodium","Bipenquinate, BRQ, DUP-785, NSC 368390","CC1=C(C(=O)O[Na])C2=CC(=CC=C2N=C1C3=CC=C(C=C3)C4=C(F)C=CC=C4)F",6.099,3,0,4]
["S3569","Spermidine","a9","L3900-34","in 10mM DMSO","Autophagy","Autophagy","Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy.",145.25,"124-20-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/spermidine.html","C7H19N3","Free Base","N/A","NCCCCNCCCN",-1.169,0,3,7]
["S3573","Trotabresib","b9","L3900-34","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Trotabresib(BMS-986378,CC-90010) is a reversible, orally active and central nervous system-penetrant inhibitor of bromodomain and extra-terminal (BET) proteins. CC-90010 is applied in the study for advanced solid tumors.",383.46,"1706738-98-8",{"v":77,"d":"77.00"},{"v":200.8,"d":"200.80"},"<1","N/A","http://www.selleckchem.com/products/cc-90010.html","C21H21NO4S","Free Base","BMS-986378,CC-90010","CN1C=C(C2=CC=CC=C2C1=O)C3=C(OCC4CC4)C=CC(=C3)[S](C)(=O)=O",2.741,4,0,5]
["S3577","Rhodamine 123","c9","L3900-34","in 10mM DMSO","ATPase,Dyes","Transmembrane Transporters","Rhodamine 123 (RH-123, R-22420) is a fluorescent cationic dye used to label mitochondria in living cells. Rhodamine 123 inhibits ADP-stimulated respiration of mitochondria with Ki = 12 μM and ATPase activity of inverted inner membrane vesicles with Ki of 126 μM and partially purified F1-ATPase with Ki of 177 μM.",380.82,"62669-70-9",{"v":76,"d":"76.00"},199.57,"<1","N/A","http://www.selleckchem.com/products/rhodamine-123.html","C21H17ClN2O3","Free Base","RH-123, R-22420","Cl.COC(=O)C1=CC=CC=C1C2=C3C=CC(=N)C=C3OC4=C2C=CC(=C4)N",3.216,3,1,3]
["S4426","Sacubitril hemicalcium salt","d9","L3900-34","in 10mM DMSO","Neprilysin","Proteases","Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).",861.04,"1369773-39-6",{"v":100,"d":"100.00"},116.14,"<1","N/A","http://www.selleckchem.com/products/sacubitril-hemicalcium-salt.html","C48H56CaN2O10","Hemicalcium salt","AHU-377 hemicalcium salt","[Ca++].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC([O-])=O.CCOC(=O)C(C)CC(CC3=CC=C(C=C3)C4=CC=CC=C4)NC(=O)CCC([O-])=O",4.569,6,2,24]
["S4427","Tenofovir alafenamide hemifumarate","e9","L3900-34","in 10mM DMSO","Reverse Transcriptase","Microbiology","Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.",{"v":1069,"d":"1069.00"},"1392275-56-7",{"v":100,"d":"100.00"},93.55,{"v":50,"d":"50.00"},46.77,"http://www.selleckchem.com/products/tenofovir-alafenamide-hemifumarate.html","C46H62N12O14P2","Hemifumarate","TAF hemifumarate, GS-7340 hemifumarate","CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OC3=CC=CC=C3.CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]4C=NC5=C(N)N=CN=C45)OC6=CC=CC=C6.OC(=O)\\C=C\\C(O)=O",3.092,18,4,26]
["S4428","Tenofovir alafenamide fumarate","f9","L3900-34","in 10mM DMSO","Reverse Transcriptase","Microbiology","Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.",592.54,"379270-38-9",{"v":100,"d":"100.00"},168.76,{"v":10,"d":"10.00"},16.88,"http://www.selleckchem.com/products/tenofovir-alafenamide-fumarate.html","C25H33N6O9P","Fumarate","TAF fumarate, GS-7340 fumarate","CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OC3=CC=CC=C3.OC(=O)\\C=C\\C(O)=O",1.565,10,2,14]
["S4429","Edoxaban","g9","L3900-34","in 10mM DMSO","Factor Xa","Metabolism","Edoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.",548.06,"480449-70-5",{"v":10,"d":"10.00"},18.25,"<1","N/A","https://www.selleckchem.com/products/edoxaban-du-176b.html","C24H30ClN7O4S","Free Base","DU-176b, Savaysa","CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(Cl)C=C4)C(=O)N(C)C",0.844,6,3,6]
["S4431","Ertugliflozin L-pyroglutamic acid","h9","L3900-34","in 10mM DMSO","SGLT","Apoptosis","Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin has the potential for the treatment of type 2 diabetes mellitus.",{"v":566,"d":"566.00"},"1210344-83-4",{"v":100,"d":"100.00"},176.68,{"v":10,"d":"10.00"},17.67,"http://www.selleckchem.com/products/ertugliflozin-l-pyroglutamic-acid.html","C27H32ClNO10","Free Base","MK-8835 L-pyroglutamic acid, PF-04971729 L-pyroglutamic acid","CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)C34OCC(CO)(O3)C(O)C(O)C4O)C=C1.OC(=O)C5CCC(=O)N5",1.349,5,5,7]
["S4432","Ixazomib Citrate (MLN9708)","a10","L3900-34","in 10mM DMSO","Proteasome","Proteases","Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.",517.12,"1239908-20-3",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://www.selleckchem.com/products/ixazomib-citrate.html","C20H23BCl2N2O9","Free Base","Ninlaro","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)C(CC(O)=O)(CC(O)=O)O2",3.497,7,2,11]
["S4433","Eliglustat hemitartrate","b10","L3900-34","in 10mM DMSO","Glucosylceramide Synthase","Metabolism","Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.",959.17,"928659-70-5",{"v":100,"d":"100.00"},104.26,{"v":100,"d":"100.00"},104.26,"http://www.selleckchem.com/products/eliglustat-hemitartrate.html","C50H78N4O14","Hemitartrate","Genz-112638, Eliglustat tartrate, Cerdelga","CCCCCCCC(=O)NC(CN1CCCC1)C(O)C2=CC3=C(OCCO3)C=C2.CCCCCCCC(=O)NC(CN4CCCC4)C(O)C5=CC6=C(OCCO6)C=C5.OC(C(O)C(O)=O)C(O)=O",-0.116,8,6,25]
["S4434","Ledipasvir acetone","c10","L3900-34","in 10mM DMSO","HCV","Microbiology","Ledipasvir (GS-5885) acetone is the active ingredient of Ledipasvir. Ledipasvir is a potent, oral active inhibitor of the hepatitis C virus (HCV) NS5A with EC50 of 31 pM and 4 pM against GT1a and GT1b replicon, respectively.",947.08,"1441674-54-9",{"v":100,"d":"100.00"},105.59,"<1","N/A","http://www.selleckchem.com/products/ledipasvir-acetone.html","C52H60F2N8O7","Free Base","GS-5885 acetone","COC(=O)NC(C(C)C)C(=O)N1CC2(CC2)CC1C3=NC=C([NH]3)C4=CC5=C(C=C4)C6=C(C=C(C=C6)C7=CC8=C(C=C7)N=C([NH]8)C9C%10CCC(C%10)N9C(=O)C(NC(=O)OC)C(C)C)C5(F)F.CC(C)=O",7.075,9,4,12]
["S4481","Guanabenz","d10","L3900-34","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.",231.08,"5051-62-7",{"v":12,"d":"12.00"},51.93,"<1","N/A","http://www.selleckchem.com/products/guanabenz.html","C8H8Cl2N4","Free Base","GBZ, GA, Wytensin, Wy-8678,BR-750","NC(=N)N\\N=C\\C1=C(Cl)C=CC=C1Cl",2.192,1,2,3]
["S4484","Trametinib DMSO solvate","e10","L3900-34","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assay. Trametinib activates autophagy and induces apoptosis.",693.53,"1187431-43-1",{"v":50,"d":"50.00"},72.09,"<1","N/A","http://www.selleckchem.com/products/trametinib-dmso-solvate.html","C28H29FIN5O5S","Free Base","GSK1120212, JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=C(F)C=C(I)C=C4)C5=CC=CC(=C5)NC(C)=O)C.C[S](C)=O",{"v":2.86,"d":"2.860"},5,2,5]
["S4488","Delafloxacin Meglumine","f10","L3900-34","in 10mM DMSO","Antibiotics","Immunology & Inflammation","Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens.",635.97,"352458-37-8",{"v":100,"d":"100.00"},157.24,{"v":100,"d":"100.00"},157.24,"http://www.selleckchem.com/products/delafloxacin-meglumine.html","C25H29ClF3N5O9","Free Base","ABT-492, RX-3341, WQ-3034, Baxdela","CNCC(O)C(O)C(O)C(O)CO.NC1=NC(=C(F)C=C1F)N2C=C(C(O)=O)C(=O)C3=CC(=C(N4CC(O)C4)C(=C23)Cl)F",-2.821,3,8,9]
["S4490","Tetracycline","g10","L3900-34","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial","Microbiology","Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.",444.43,"60-54-8",{"v":89,"d":"89.00"},200.26,"<1","N/A","http://www.selleckchem.com/products/tetracycline.html","C22H24N2O8","Free Base","TC","CN(C)C1C2CC3C(=C(O)C4=C(C=CC=C4O)C3(C)O)C(=O)C2(O)C(=C(C(N)=O)C1=O)O",-1.011,3,4,2]
["S4491","Cetylpyridinium chloride monohydrate","h10","L3900-34","in 10mM DMSO","Influenza Virus","Microbiology","Cetylpyridinium chloride (CPC, Hexadecylpyridinium chloride) monohydrate is a broad-spectrum antimicrobial agent that possesses virucidal activity against susceptible and resistant strains of influenza virus by targeting and disrupting the viral envelope.",{"v":358,"d":"358.00"},"6004-24-6",{"v":72,"d":"72.00"},201.12,{"v":72,"d":"72.00"},201.12,"http://www.selleckchem.com/products/cetylpyridinium-chloride-monohydrate.html","C21H40ClNO","Monohydrate","CPC monohydrate, Hexadecylpyridinium chloride monohydrate","O.[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1",5.356,0,0,15]
["S4493","Sodium nitroprusside","a11","L3900-34","in 10mM DMSO","Others","Others","Sodium nitroprusside (SNP, Ro 21-2498) is a generically available and rapid-acting intravenous (IV) vasodilator that dilates cerebral vessels and increases internal carotid (ICA) flow.",261.92,"14402-89-2",{"v":52,"d":"52.00"},198.53,{"v":52,"d":"52.00"},198.53,"http://www.selleckchem.com/products/sodium-nitroprusside.html","C5FeN6O2Na","Sodium","SNP, Ro 21-2498","[Na+].[Na+].[Fe++](|[C-]#N)(|[C-]#N)(|[C-]#N)(|[C-]#N)(|[C-]#N)|N#[O+]",0.204,0,1,0]
["S4496","Maltose monohydrate","b11","L3900-34","in 10mM DMSO","Others","Others","Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate, an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables).",360.31,"6363-53-7",{"v":72,"d":"72.00"},199.83,{"v":72,"d":"72.00"},199.83,"http://www.selleckchem.com/products/maltose-monohydrate.html","C12H24O12","Monohydrate","Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose","O.OCC(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)C(O)C=O",-4.745,3,8,8]
["S4531","Iohexol","c11","L3900-34","in 10mM DMSO","Others","Others","Iohexol (Omnipaque) is a radiographic contrast agent that can be used as an exogenous filtration marker for accurate glomerular filtration rate (GFR) estimates.",821.14,"66108-95-0",{"v":100,"d":"100.00"},121.78,{"v":100,"d":"100.00"},121.78,"http://www.selleckchem.com/products/iohexol.html","C19H26I3N3O9","Free Base","Omnipaque","CC(=O)N(CC(O)CO)C1=C(I)C(=C(I)C(=C1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO",-1.844,3,8,12]
["S4643","KB-R7943 mesylate","d11","L3900-34","in 10mM DMSO","Autophagy,JNK,NCX","Transmembrane Transporters","KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.",{"v":427.5,"d":"427.50"},"182004-65-5",{"v":86,"d":"86.00"},201.17,"<1","N/A","http://www.selleckchem.com/products/kb-r7943-mesylate.html","C17H21N3O6S2","Mesylate","N/A","C[S](O)(=O)=O.NC(=N)SCCC1=CC=C(OCC2=CC=C(C=C2)[N+]([O-])=O)C=C1",3.376,1,1,8]
["S4713","Atropine","e11","L3900-34","in 10mM DMSO","AChR","Neuronal Signaling","Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.",289.37,"51-55-8",{"v":58,"d":"58.00"},200.44,"<1","N/A","http://www.selleckchem.com/products/atropine.html","C17H23NO3","Free Base","N/A","CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",1.721,2,1,5]
["S4842","Balsalazide","f11","L3900-34","in 10mM DMSO","Immunology & Inflammation related,Interleukins,STAT","Immunology & Inflammation","Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.",357.32,"80573-04-2",{"v":71,"d":"71.00"},{"v":198.7,"d":"198.70"},{"v":71,"d":"71.00"},{"v":198.7,"d":"198.70"},"http://www.selleckchem.com/products/balsalazide.html","C17H15N3O6","Free Base","Colazal, Giazo","OC(=O)CCNC(=O)C1=CC=C(C=C1)N=NC2=CC(=C(O)C=C2)C(O)=O",2.524,5,2,7]
["S4895","Nilotinib hydrochloride monohydrate","g11","L3900-34","in 10mM DMSO","AMPK,Autophagy,Bcr-Abl","Angiogenesis","Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.",583.99,"923288-90-8",{"v":100,"d":"100.00"},171.24,"<1","N/A","http://www.selleckchem.com/products/nilotinib-hydrochloride-monohydrate.html","C28H25ClF3N7O2","Hydrochloride monohydrate","Tasigna, AMN-107 hydrochloride monohydrate","O.Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C)C=C3)NC4=NC=CC(=N4)C5=CN=CC=C5)C(F)(F)F",5.259,5,2,7]
["S4929","Enasidenib Mesylate","h11","L3900-34","in 10mM DMSO","Dehydrogenase","Metabolism","Enasidenib (Idhifa, AG-221) mesylate is an orally available, selective and potent inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).",569.48,"1650550-25-6",{"v":100,"d":"100.00"},{"v":175.6,"d":"175.60"},"<1","N/A","http://www.selleckchem.com/products/enasidenib-mesylate.html","C20H21F6N7O4S","Mesylate","Idhifa, AG-221 mesylate","CC(C)(O)CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F.C[S](O)(=O)=O",4.464,5,2,8]
["S4944","Fostamatinib disodium hexahydrate","a2","L3900-35","in 10mM DMSO","Syk","Angiogenesis","Fostamatinib (R788) disodium (Tamatinib Fosdium) hexahydrate, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay.",732.51,"914295-16-2",{"v":100,"d":"100.00"},136.52,"<1","N/A","http://www.selleckchem.com/products/fostamatinib-disodium-hexahydrate.html","C23H36FN6Na2O15P","Disodium hexahydrate","Tavalisse, R788 disodium hexahydrate, Tamatinib Fosdium hexahydrate","O.O.O.O.O.O.[Na+].[Na+].COC1=CC(=CC(=C1OC)OC)NC2=NC=C(F)C(=N2)NC3=NC4=C(OC(C)(C)C(=O)N4CO[P]([O-])([O-])=O)C=C3",0.038,9,2,10]
["S4947","Regorafenib Hydrochloride","b2","L3900-35","in 10mM DMSO","c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (Stivarga, BAY 73-4506) Hydrochloride is a multi-target inhibitor for VEGFR1, Murine VEGFR2/3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM, 4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.",519.28,"835621-07-3",{"v":100,"d":"100.00"},192.57,"<1","N/A","http://www.selleckchem.com/products/regorafenib-hydrochloride.html","C21H16Cl2F4N4O3","Hydrochloride","Stivarga, BAY 73-4506 hydrochloride","Cl.CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)F",4.763,4,3,6]
["S4948","Rucaparib","c2","L3900-35","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Rucaparib (Rubraca, AG014699, PF01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.",323.36,"283173-50-2",{"v":65,"d":"65.00"},201.01,"<1","N/A","http://www.selleckchem.com/products/rucaparib.html","C19H18FN3O","Free Base","Rubraca, AG014699, PF01367338","CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)[NH]2",2.959,1,3,3]
["S4967","Ceritinib dihydrochloride","d2","L3900-35","in 10mM DMSO","ALK,IGF-1R,Serine/threonin kinase","Protein Tyrosine Kinase","Ceritinib (Zykadia, LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive inhibitor of ALK with IC50 of 0.2 nM. Ceritinib dihydrochloride also inhibits InsR, IGF-1R and STK22D with IC50 of 7 nM, 8 nM and 23 nM, respectively. Ceritinib exhibits antitomor activity.",631.06,"1380575-43-8",{"v":13,"d":"13.00"},{"v":20.6,"d":"20.60"},"<1","N/A","http://www.selleckchem.com/products/ceritinib-dihydrochloride.html","C28H38Cl3N5O3S","Dihydrochloride","Zykadia, LDK378 dihydrochloride","Cl.Cl.CC(C)OC1=C(NC2=NC=C(Cl)C(=N2)NC3=CC=CC=C3[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4",7.243,5,3,9]
["S5008","Ciprofloxacin hydrochloride","e2","L3900-35","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,Topoisomerase","Microbiology","Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).",{"v":367.8,"d":"367.80"},"93107-08-5",{"v":7,"d":"7.00"},19.03,{"v":74,"d":"74.00"},{"v":201.2,"d":"201.20"},"http://www.selleckchem.com/products/ciprofloxacin-hydrochloride.html","C17H19ClFN3O3","Hydrochloride","CPX, Cetraxal, Ciloxan, Cipro, Bay-09867 hydrochloride","Cl.OC(=O)C1=CN(C2CC2)C3=CC(=C(F)C=C3C1=O)N4CCNCC4",-0.888,2,1,3]
["S5026","Irinotecan hydrochloride","f2","L3900-35","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.",623.14,"100286-90-6",{"v":100,"d":"100.00"},160.48,"<1","N/A","http://www.selleckchem.com/products/irinotecan-hydrochloride.html","C33H39ClN4O6","Hydrochloride","CPT-11 hydrochloride, (+)-Irinotecan hydrochloride","Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=C1C=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C5)C(O)(CC)C(=O)OC4",4.068,6,0,5]
["S5181","Levobupivacaine","g2","L3900-35","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. Levobupivacaine exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.",288.43,"27262-47-1",{"v":58,"d":"58.00"},201.09,"<1","N/A","http://www.selleckchem.com/products/levobupivacaine.html","C18H28N2O","Free Base","Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine","CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C",{"v":4.31,"d":"4.310"},1,1,5]
["S5185","Perospirone","h2","L3900-35","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.",426.57,"150915-41-6",{"v":85,"d":"85.00"},199.26,"<1","N/A","http://www.selleckchem.com/products/perospirone.html","C23H30N4O2S","Free Base","SM-9018 free base","O=C1C2CCCCC2C(=O)N1CCCCN3CCN(CC3)C4=NSC5=CC=CC=C45",4.041,3,0,6]
["S5187","Ribociclib hydrochloride","a3","L3900-35","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) hydrochloride is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.",{"v":471,"d":"471.00"},"1211443-80-9",{"v":94,"d":"94.00"},199.58,{"v":94,"d":"94.00"},199.58,"http://www.selleckchem.com/products/ribociclib-hydrochloride.html","C23H31ClN8O","Hydrochloride","LEE011 hydrochloride","Cl.CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",3.282,4,2,5]
["S5188","Ribociclib succinate","b3","L3900-35","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) succinate (Kisqali) is a highly specific dual inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM, respectively.",552.63,"1374639-75-4",{"v":100,"d":"100.00"},180.95,"<1","N/A","http://www.selleckchem.com/products/ribociclib-succinate.html","C27H36N8O5","Succinate","LEE011 succinate, Kisqali","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5.OC(=O)CCC(O)=O",-0.164,6,2,8]
["S5189","Lesinurad sodium","c3","L3900-35","in 10mM DMSO","OAT","Transmembrane Transporters","Lesinurad (Selexipag, RDEA-594) sodium (Zurampic) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout. Lesinurad sodium inhibits the uric acid transporter URAT1 and Kidney transporter OAT with IC50/Km of 4.3 μM/0.85 μM and 3.5 μM/2 μM for OAT1 and OAT3, respectively.",426.26,"1151516-14-1",{"v":85,"d":"85.00"},199.41,{"v":8,"d":"8.00"},18.77,"http://www.selleckchem.com/products/lesinurad-sodium.html","C17H13BrN3NaO2S","Sodium","Selexipag, Zurampic, RDEA-594 sodium","[Na+].[O-]C(=O)CSC1=NN=C(Br)[N]1C2=CC=C(C3CC3)C4=CC=CC=C24",2.783,2,0,5]
["S5190","Crizotinib hydrochloride","d3","L3900-35","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",{"v":486.8,"d":"486.80"},"1415560-69-8",{"v":97,"d":"97.00"},199.26,{"v":97,"d":"97.00"},199.26,"http://www.selleckchem.com/products/crizotinib-hydrochloride.html","C21H23Cl3FN5O","Hydrochloride","Xalkori, PF-02341066 hydrochloride","Cl.CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",4.075,3,2,5]
["S5191","Cinacalcet","e3","L3900-35","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.",357.41,"226256-56-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/cinacalcet.html","C22H22F3N","Free Base","AMG073, Sensipar, Cin","CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=CC=CC=C23",5.956,0,1,7]
["S5192","S-(+)-Ketoprofen","f3","L3900-35","in 10mM DMSO","COX","Immunology & Inflammation","S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.",254.28,"22161-81-5",{"v":51,"d":"51.00"},200.57,"<1","N/A","http://www.selleckchem.com/products/s-ketoprofen.html","C16H14O3","Free Base","Actron, (S)-Ketoprofen, Dexketoprofen","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S5193","L-Thyroxine sodium salt pentahydrate","g3","L3900-35","in 10mM DMSO","THR","Metabolism","L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate is a synthetic T4 hormone used to counterbalance hypothyroidism.",888.93,"6106-07-6",{"v":100,"d":"100.00"},112.49,"<1","N/A","http://www.selleckchem.com/products/l-thyroxine-sodium-salt-pentahydrate.html","C15H20I4NNaO9","Sodium salt pentahydrate","Sodium Levothyroxine pentahydrate, L-T4 sodium pentahydrate","O.O.O.O.O.[Na+].NC(CC1=CC(=C(OC2=CC(=C(O)C(=C2)I)I)C(=C1)I)I)C([O-])=O",1.994,1,2,5]
["S5194","Furosemide sodium","h3","L3900-35","in 10mM DMSO","GABA Receptor,NKCC","Transmembrane Transporters","Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.",352.73,"41733-55-5",{"v":71,"d":"71.00"},201.29,{"v":71,"d":"71.00"},201.29,"http://www.selleckchem.com/products/furosemide-sodium.html","C12H10ClN2NaO5S","Sodium","Lasix, Frusemide Sodium","[Na+].N[S](=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C([O-])=O",-0.071,3,2,5]
["S5196","Promethazine","a4","L3900-35","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.",284.42,"60-87-7",{"v":29,"d":"29.00"},101.96,"<1","N/A","http://www.selleckchem.com/products/promethazine.html","C17H20N2S","Free Base","N/A","CC(CN1C2=CC=CC=C2SC3=CC=CC=C13)N(C)C",{"v":4.39,"d":"4.390"},0,0,3]
["S5300","Trometamol hydrochloride","b4","L3900-35","in 10mM DMSO","Others","Others","Trometamol (THAM, Tromethamine, TRIS-HCL) hydrochloride, a proton acceptor, is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol rapidly restores pH and acid-base regulation in acidaemia.",{"v":157.6,"d":"157.60"},"1185-53-1",{"v":32,"d":"32.00"},203.05,{"v":32,"d":"32.00"},203.05,"http://www.selleckchem.com/products/trometamol-hydrochloride.html","C4H12ClNO3","Hydrochloride","THAM, Tromethamine hydrochloride, TRIS-HCL","Cl.NC(CO)(CO)CO",-1.999,0,4,3]
["S5608","Pantoprazole sodium hydrate","c4","L3900-35","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.",864.75,"164579-32-2",{"v":100,"d":"100.00"},115.64,{"v":17,"d":"17.00"},19.66,"http://www.selleckchem.com/products/pantoprazole-sodium-hydrate.html","C32H34F4N6Na2O11S2","Sodium hydrate","Protonix, BY1023 sodium hydrate, SKF96022 sodium hydrate","O.O.O.[Na+].[Na+].COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F.COC4=C(OC)C(=NC=C4)C[S](=O)C5=NC6=C([N-]5)C=CC(=C6)OC(F)F",5.145,12,0,14]
["S5644","Ceftriaxone Sodium","d4","L3900-35","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity.",598.54,"74578-69-1",{"v":100,"d":"100.00"},167.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ceftriaxone-sodium.html","C18H16N8Na2O7S3","Sodium","N/A","[Na+].[Na+].CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)CSC3=NC(=O)C(=NN3C)[O-])C4=CSC(=N4)N",-2.451,8,2,8]
["S5738","Megestrol","e4","L3900-35","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.",342.47,"3562-63-8",{"v":68,"d":"68.00"},198.56,"<1","N/A","http://www.selleckchem.com/products/megestrol.html","C22H30O3","Free Base","Megace","CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C",3.126,2,0,1]
["S5777","Ipratropium bromide monohydrate","f4","L3900-35","in 10mM DMSO","AChR","Neuronal Signaling","Ipratropium bromide (Atrovent, Sch 1000) monohydrate is an antagonist of muscarinic acetylcholine receptors (mAChR) with IC50 of 2.9 nM, 2.0 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively.",430.38,"66985-17-9",{"v":86,"d":"86.00"},199.82,{"v":86,"d":"86.00"},199.82,"http://www.selleckchem.com/products/ipratropium-bromide-monohydrate.html","C20H32BrNO4","Monohydrate","Atrovent, Sch 1000 monohydrate","O.[Br-].CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3",-1.533,2,1,6]
["S5785","Norethindrone acetate","g4","L3900-35","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.",340.46,"51-98-9",{"v":68,"d":"68.00"},199.73,"<1","N/A","http://www.selleckchem.com/products/norethindrone-acetate.html","C22H28O3","Free Base","19-Norethindrone acetate, NA","CC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4C3CCC12C)C#C",4.694,3,0,2]
["S5786","Bromfenac sodium hydrate","h4","L3900-35","in 10mM DMSO","COX","Immunology & Inflammation","Bromfenac sodium hydrate (Bromsite, Bromday, Prolensa, Xibrom), a brominated nonsteroidal anti-inflammatory drugs (NSAID) with strong in vitro anti-inflammatory potency, is a potent and orally active inhibitor of COX with IC50 of 5.56 nM and 7.45 nM for COX-1 and COX-2, respectively.",766.34,"120638-55-3",{"v":100,"d":"100.00"},130.49,{"v":100,"d":"100.00"},130.49,"http://www.selleckchem.com/products/bromfenac-sodium-hydrate.html","C30H28Br2N2Na2O9","Sodium hydrate","Bromsite, Bromday, Prolensa, Xibrom","O.O.O.[Na+].[Na+].NC1=C(CC([O-])=O)C=CC=C1C(=O)C2=CC=C(Br)C=C2.NC3=C(CC([O-])=O)C=CC=C3C(=O)C4=CC=C(Br)C=C4",2.231,2,2,8]
["S5860","Larotrectinib","a5","L3900-35","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","Larotrectinib (Vitrakvi, LOXO-101, ARRY-470) is an ATP-competitive, oral administered and highly selective inhibitor of the tropomyosin-related kinase (TRK) family receptors.",428.44,"1223403-58-4",{"v":86,"d":"86.00"},200.73,"<1","N/A","http://www.selleckchem.com/products/larotrectinib.html","C21H22F2N6O2","Free Base","Vitrakvi, LOXO-101, ARRY-470","OC1CCN(C1)C(=O)NC2=C3N=C(C=C[N]3N=C2)N4CCCC4C5=CC(=CC=C5F)F",1.981,3,2,3]
["S5864","Levocetirizine","b5","L3900-35","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor.",388.89,"130018-77-8",{"v":78,"d":"78.00"},200.57,{"v":78,"d":"78.00"},200.57,"http://www.selleckchem.com/products/levocetirizine.html","C21H25ClN2O3","Free Base","LCZ, (R)-Cetirizine","OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",0.453,2,0,8]
["S5898","Efonidipine hydrochloride monoethanolate","c5","L3900-35","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) hydrochloride monoethanolate is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. Efonidipine hydrochloride monoethanolate also suppresses aldosterone secretion from the adrenal.",714.18,"111011-76-8",{"v":100,"d":"100.00"},140.02,"<1","N/A","http://www.selleckchem.com/products/efonidipine-hydrochloride-monoethanolate.html","C36H45ClN3O8P","Hydrochloride monoethanolate","NZ-105 hydrochloride monoethanolate","Cl.CCO.CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",5.329,4,2,11]
["S5922","L-Carnitine hydrochloride","d5","L3900-35","in 10mM DMSO","Leukotriene","Metabolism","L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.",197.66,"6645-46-1",{"v":40,"d":"40.00"},202.37,{"v":40,"d":"40.00"},202.37,"http://www.selleckchem.com/products/l-carnitine-hydrochloride.html","C7H16ClNO3","Hydrochloride","(R)-Carnitine hydrochloride, Levocarnitine hydrochloride","[Cl-].C[N+](C)(C)CC(O)CC(O)=O",{"v":-4.49,"d":"-4.490"},1,1,4]
["S5942","Bisoprolol","e5","L3900-35","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.",325.44,"66722-44-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/bisoprolol.html","C18H31NO4","Free Base","N/A","CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1",2.031,3,2,12]
["S5949","Metoclopramide hydrochloride hydrate","f5","L3900-35","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.",354.27,"54143-57-6",{"v":71,"d":"71.00"},200.41,{"v":71,"d":"71.00"},200.41,"http://www.selleckchem.com/products/metoclopramide-hydrochloride-hydrate.html","C14H25Cl2N3O3","Hydrochloride hydrate","Clorpa, Gimoti, Maxolon, Reglan","O.Cl.CCN(CC)CCNC(=O)C1=CC(=C(N)C=C1OC)Cl",{"v":1.95,"d":"1.950"},2,2,7]
["S5953","Menadione bisulfite sodium","g5","L3900-35","in 10mM DMSO","CDK,DNA/RNA Synthesis,phosphatase","Metabolism","Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.",276.24,"130-37-0",{"v":55,"d":"55.00"},{"v":199.1,"d":"199.10"},{"v":55,"d":"55.00"},{"v":199.1,"d":"199.10"},"http://www.selleckchem.com/products/menadione-bisulfite-sodium.html","C11H9NaO5S","Sodium","Menadione sodium bisulfite, Vitamin K3 sodium bisulfite","[Na+].CC1(CC(=O)C2=CC=CC=C2C1=O)[S]([O-])(=O)=O",-1.282,2,0,1]
["S5957","Vardenafil hydrochloride","h5","L3900-35","in 10mM DMSO","PDE","Metabolism","Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.",525.06,"224785-91-5",{"v":100,"d":"100.00"},190.45,{"v":100,"d":"100.00"},190.45,"http://www.selleckchem.com/products/vardenafil-hydrochloride.html","C23H33ClN6O4S","Hydrochloride","BAY38-9456, Levitra, Staxyn","Cl.CCCC1=NC(=C2[N]1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S](=O)(=O)N4CCN(CC)CC4)C",{"v":2.73,"d":"2.730"},6,1,8]
["S5958","Metformin","a6","L3900-35","in 10mM DMSO","AMPK,Apoptosis related,JNK,Mitophagy,p38 MAPK","PI3K/Akt/mTOR","Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",129.16,"657-24-9",{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},{"v":26,"d":"26.00"},{"v":201.3,"d":"201.30"},"http://www.selleckchem.com/products/metformin.html","C4H11N5","Free Base","1,1-Dimethylbiguanide","CN(C)C(=N)NC(N)=N",-0.742,0,2,3]
["S5959","Tenofovir Disoproxil","b6","L3900-35","in 10mM DMSO","HIV,Reverse Transcriptase","Microbiology","Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.",519.44,"201341-05-1",{"v":100,"d":"100.00"},192.52,"<1","N/A","http://www.selleckchem.com/products/tenofovir-disoproxil.html","C19H30N5O10P","Free Base","Bis(POC)-PMPA, GS 4331","CC(C)OC(=O)OCO[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OCOC(=O)OC(C)C",{"v":1.69,"d":"1.690"},12,1,17]
["S5960","Dabigatran etexilate mesylate","c6","L3900-35","in 10mM DMSO","Thrombin","Proteases","Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.",723.84,"872728-81-9",{"v":100,"d":"100.00"},138.15,"<1","N/A","http://www.selleckchem.com/products/dabigatran-etexilate-mesylate.html","C35H45N7O8S","Mesylate","Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate","CCCCCCOC(=O)NC(=N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)[N]2C)C=C1.C[S](O)(=O)=O",5.337,7,2,18]
["S5966","Amlodipine maleate","d6","L3900-35","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",524.95,"88150-47-4",{"v":100,"d":"100.00"},190.49,"<1","N/A","http://www.selleckchem.com/products/amlodipine-maleate.html","C24H29ClN2O9","Maleate","Amvaz, UK-48340 maleate","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C.OC(=O)\\C=C/C(O)=O",-0.864,7,2,12]
["S5971","Pemetrexed","e6","L3900-35","in 10mM DMSO","Apoptosis related,Autophagy,DHFR,DNA/RNA Synthesis,Thymidylate Synthase","Apoptosis","Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.",427.41,"137281-23-3",{"v":85,"d":"85.00"},198.87,"<1","N/A","http://www.selleckchem.com/products/pemetrexed.html","C20H21N5O6","Free Base","LY231514, Alimta","NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N1",1.144,5,4,9]
["S5972","Hydrocortisone hemisuccinate","f6","L3900-35","in 10mM DMSO","Interleukins","Immunology & Inflammation","Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid with anti-inflammatory properties, is an inhibitor of proinflammatory cytokine with IC50 of 6.7 μM and 21.4 μM for Interleukin-6 (IL-6) and IL-3, respectively.",462.53,"2203-97-6",{"v":93,"d":"93.00"},201.07,"<1","N/A","http://www.selleckchem.com/products/hydrocortisone-hemisuccinate.html","C25H34O8","Hemisuccinate","A-hydrocort, Hydrocortisone 21-hemisuccinate","CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)COC(=O)CCC(O)=O)C4(C)CC(O)C23",1.507,5,1,7]
["S5981","S(-)-Propranolol hydrochloride","g6","L3900-35","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.",{"v":295.8,"d":"295.80"},"4199-10-4",{"v":59,"d":"59.00"},199.46,{"v":59,"d":"59.00"},199.46,"http://www.selleckchem.com/products/s-propranolol-hydrochloride.html","C16H22ClNO2","Hydrochloride","Hemangeol, Inderal","Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12",2.922,1,2,6]
["S6466","Eicosapentaenoic acid ethyl ester","h6","L3900-35","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.",{"v":330.5,"d":"330.50"},"86227-47-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/eicosapentaenoic-acid-ethyl-ester.html","C22H34O2","Free Base","AMR101, EPA ethyl ester, Ethyl eicosapentaenoate","CCOC(=O)CCC\\C=C/C/C=C\\C\\C=C/C/C=C\\C\\C=C/CC",6.569,2,0,15]
["S6584","Amdinocillin","a7","L3900-35","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.",325.43,"32887-01-7",{"v":65,"d":"65.00"},199.74,{"v":65,"d":"65.00"},199.74,"http://www.selleckchem.com/products/amdinocillin.html","C15H23N3O3S","Free Base","Mecillinam, Coactin, FL 1060","CC1(C)SC2C(N=CN3CCCCCC3)C(=O)N2C1C(O)=O",1.186,3,0,3]
["S6988","Lusutrombopag","b7","L3900-35","in 10mM DMSO","TpoR","Immunology & Inflammation","Lusutrombopag (Mulpleta, S-888711) is an orally bioavailable thrombopoietin (TPO) receptor agonist being developed for chronic liver disease (CLD).",591.55,"1110766-97-6",{"v":100,"d":"100.00"},169.05,"<1","N/A","http://www.selleckchem.com/products/lusutrombopag.html","C29H32Cl2N2O5S","Free Base","Mulpleta, S-888711","CCCCCCOC(C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(\\C=C(/C)C(O)=O)C(=C3)Cl)Cl",7.837,5,1,13]
["S7220","Fostemsavir","c7","L3900-35","in 10mM DMSO","gp120/CD4","Immunology & Inflammation","Fostemsavir (BMS-663068, Rukobia), the phosphonooxymethyl prodrug of BMS626529, is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of < 10 nM.",583.49,"864953-29-7",{"v":100,"d":"100.00"},171.38,"<1","N/A","http://www.selleckchem.com/products/bms-663068.html","C25H26N7O8P","Free Base","BMS-663068, Rukobia","COC1=CN=C([N]2C=NC(=N2)C)C3=C1C(=C[N]3CO[P](O)(O)=O)C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5",0.752,8,0,8]
["S7853","Pelabresib (CPI-0610)","d7","L3900-35","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Pelabresib (CPI-0610) is a potent and selective benzoisoxazoloazepine BET bromodomain inhibitor with an IC50 of 39 nM for BRD4-BD1 in TR-FRET assay and currently undergoing human clinical trials for hematological malignancies. CPI-0610 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",365.81,"1380087-89-7",{"v":73,"d":"73.00"},199.56,"<1","N/A","http://www.selleckchem.com/products/cpi-0610.html","C20H16ClN3O2","Free Base","N/A","CC1=NOC2=C1C3=CC=CC=C3C(=NC2CC(N)=O)C4=CC=C(Cl)C=C4",3.483,4,1,3]
["S8033","6-Iodopravadoline (AM630)","e7","L3900-35","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","6-Iodopravadoline (AM630) is a selective cannabinoid CB2 receptor antagonist with Ki of 31.2 nM.",504.36,"164178-33-0",{"v":50,"d":"50.00"},99.14,"<1","N/A","http://www.selleckchem.com/products/6-iodopravadoline.html","C23H25IN2O3","Free Base","N/A","COC1=CC=C(C=C1)C(=O)C2=C(C)[N](CCN3CCOCC3)C4=C2C=CC(=C4)I",4.267,3,0,6]
["S8682","AMG 487","f7","L3900-35","in 10mM DMSO","CXCR","Immunology & Inflammation","AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.",603.59,"473719-41-4",{"v":100,"d":"100.00"},165.68,"<1","N/A","http://www.selleckchem.com/products/amg-487.html","C32H28F3N5O4","Free Base","N/A","CCOC1=CC=C(C=C1)N2C(=O)C3=CC=CN=C3N=C2C(C)N(CC4=CC=CN=C4)C(=O)CC5=CC=C(OC(F)(F)F)C=C5",6.334,7,0,11]
["S8917","ME-401","g7","L3900-35","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","ME-401 (P110δ-IN-1, PWT-143) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay.",604.77,"1595129-71-7",{"v":20,"d":"20.00"},33.07,"<1","N/A","http://www.selleckchem.com/products/me-401.html","C31H40N8O3S","Free Base","P110δ-IN-1, PWT-143","CN1CCC(CC1)C2=CC=CC=C2CC(C)(C)NC3=NC(=NC(=N3)N4CCOCC4)[N]5C6=CC=CC=C6N=C5[S](C)(=O)=O",5.711,7,1,8]
["S8932","Remdesivir (GS-5734)","h7","L3900-35","in 10mM DMSO","Antiviral,COVID-19,DNA/RNA Synthesis","Microbiology","Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.",602.58,"1809249-37-3",{"v":100,"d":"100.00"},165.95,"<1","N/A","http://www.selleckchem.com/products/remdesivir.html","C27H35N6O8P","Free Base","N/A","CCC(CC)COC(=O)C(C)N[P](=O)(OCC1OC(C#N)(C(O)C1O)C2=CC=C3[N]2N=CN=C3N)OC4=CC=CC=C4",2.174,7,4,14]
["S8956","(Z)-4-Hydroxytamoxifen","a8","L3900-35","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","(Z)-4-Hydroxytamoxifen ((Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen) is a selective modulator of estrogen receptor (SERM) with IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor.",387.51,"68047-06-3",{"v":78,"d":"78.00"},201.29,"<1","N/A","http://www.selleckchem.com/products/z-4-hydroxytamoxifen.html","C26H29NO2","Free Base","(Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3",6.077,1,1,8]
["S9609","Amcenestrant (SAR439859)","b8","L3900-35","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation.",554.48,"2114339-57-8",{"v":100,"d":"100.00"},180.35,"<1","N/A","http://www.selleckchem.com/products/sar439859.html","C31H30Cl2FNO3","Free Base","N/A","OC(=O)C1=CC2=C(C=C1)C(=C(CCC2)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(OC5CCN(CCCF)C5)C=C4",{"v":4.73,"d":"4.730"},2,0,8]
["S9667","Inobrodib (CCS-1477)","c8","L3900-35","in 10mM DMSO","Androgen Receptor,Epigenetic Reader Domain,Myc","Epigenetics","Inobrodib (CCS1477; CBP-IN-1; CBP/p300-IN-4）is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.",{"v":534.6,"d":"534.60"},"2222941-37-7",{"v":100,"d":"100.00"},187.06,"<1","N/A","http://www.selleckchem.com/products/ccs-1477-cbp-in-1-.html","C30H32F2N4O3","Free Base","CBP-IN-1, CBP/p300-IN-4","COC1CCC(CC1)[N]2C(=NC3=CC(=CC=C23)C4=C(C)ON=C4C)C5CCCC(=O)N5C6=CC(=C(F)C=C6)F",5.343,5,0,5]
["S9693","Vericiguat","d8","L3900-35","in 10mM DMSO","Guanylate Cyclase","GPCR & G Protein","Vericiguat (BAY1021189, Verquvo) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.",426.38,"1350653-20-1",{"v":85,"d":"85.00"},199.35,"<1","N/A","http://www.selleckchem.com/products/vericiguat.html","C19H16F2N8O2","Free Base","BAY1021189, Verquvo","COC(=O)NC1=C(N)N=C(N=C1N)C2=N[N](CC3=CC=CC=C3F)C4=NC=C(F)C=C24",2.341,6,3,5]
["S9715","Lanraplenib (GS-9876)","e8","L3900-35","in 10mM DMSO","Syk","Angiogenesis","Lanraplenib (GS-9876, GS-SYK) is a potent, highly selective and orally active inhibitor of Spleen Tyrosine Kinase (SYK) with IC50 of 9.5 nM. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.",{"v":443.5,"d":"443.50"},"1800046-95-0",{"v":89,"d":"89.00"},200.68,"<1","N/A","http://www.selleckchem.com/products/lanraplenib.html","C23H25N9O","Free Base","GS-SYK","NC1=CN=CC(=N1)C2=C[N]3C=CN=C3C(=N2)NC4=CC=C(C=C4)N5CCN(CC5)C6COC6",1.211,5,2,5]
["S9721","Farudodstat","f8","L3900-35","in 10mM DMSO","AP-1,Apoptosis related,Dehydrogenase","Metabolism","Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.",356.32,"1035688-66-4",{"v":71,"d":"71.00"},199.26,"<1","N/A","http://www.selleckchem.com/products/aslan003.html","C19H14F2N2O3","Free Base","LAS 186323,ASLAN003","COC1=CC=CC(=C1)C2=CC(=C(NC3=NC=CC=C3C(O)=O)C(=C2)F)F",4.311,3,1,5]
["S9731","PF-00835231","g8","L3900-35","in 10mM DMSO","COVID-19,SARS-CoV","Microbiology","PF-00835231 is a 3CLpro (Mpro) inhibitor that may targets SARS-CoV-2 protease 3CLpro as a potential new treatment for COVID-19.",472.53,"870153-29-0",{"v":95,"d":"95.00"},201.05,"<1","N/A","http://www.selleckchem.com/products/pf-00835231.html","C24H32N4O6","Free Base","N/A","COC1=CC=CC2=C1C=C([NH]2)C(=O)NC(CC(C)C)C(=O)NC(CC3CCNC3=O)C(=O)CO",1.107,5,5,11]
["S9742","Indisulam","h8","L3900-35","in 10mM DMSO","Carbonic Anhydrase,CDK","Metabolism","Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.",385.85,"165668-41-7",{"v":77,"d":"77.00"},199.56,"<1","N/A","http://www.selleckchem.com/products/indisulam.html","C14H12ClN3O4S2","Free Base","E7070","N[S](=O)(=O)C1=CC=C(C=C1)[S](=O)(=O)NC2=C3[NH]C=C(Cl)C3=CC=C2",{"v":1.98,"d":"1.980"},4,3,4]
["S9783","6-Aminonicotinamide","a9","L3900-35","in 10mM DMSO","Dehydrogenase","Metabolism","6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM.",137.14,"329-89-5",{"v":27,"d":"27.00"},196.88,"<1","N/A","http://www.selleckchem.com/products/6-aminonicotinamide.html","C6H7N3O","Free Base","6AN","NC(=O)C1=CC=C(N)N=C1",-0.526,2,2,1]
["S9786","BDTX-189","b9","L3900-35","in 10mM DMSO","EGFR,HER2,RIP kinase","Protein Tyrosine Kinase","BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.",561.03,"2414572-47-5",{"v":100,"d":"100.00"},178.24,"<1","N/A","http://www.selleckchem.com/products/bdtx-189.html","C29H29ClN6O4","Free Base","N/A","ClC1=C(OCC2=NC=CC=C2)C=CC(=C1)NC3=NC=NC4=C3C=C(NC(=O)C=C)C(=C4)OCCN5CCOCC5",4.401,7,2,11]
["S9864","Elimusertib (BAY-1895344)","c9","L3900-35","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.",375.43,"1876467-74-1",{"v":17,"d":"17.00"},45.28,"<1","N/A","http://www.selleckchem.com/products/elimusertib-bay-1895344-.html","C20H21N7O","Free Base","N/A","CC1COCCN1C2=CC(=C3C=CN=C(C4=CC=N[NH]4)C3=N2)C5=CC=N[N]5C",2.774,5,1,3]
["P1203","Avexitide","d9","L3900-35","in 10mM DMSO","Glucagon Receptor","GPCR & G Protein","Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.",3369.76,"133514-43-9",{"v":100,"d":"100.00"},29.68,{"v":100,"d":"100.00"},29.68,"http://www.selleckchem.com/products/avexitide.html","C149H234N40O47S","Free Base","Exendin (9-39), Exendin-3 (9-39)","CCC(C)C(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC2=C[NH]C3=CC=CC=C23)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NCC(=O)NCC(=O)N4CCCC4C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N5CCCC5C(=O)N6CCCC6C(=O)N7CCCC7C(=O)NC(CO)C(N)=O",{"v":-21.4,"d":"-21.400"},38,39,109]
["S0081","DDD107498","e9","L3900-35","in 10mM DMSO","Parasite","Microbiology","DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.",462.56,"1469439-69-7",{"v":93,"d":"93.00"},201.05,{"v":93,"d":"93.00"},201.05,"http://www.selleckchem.com/products/ddd107498.html","C27H31FN4O2","Free Base","M-5717, DDD-498","FC1=CC2=C(C=C1)N=C(C=C2C(=O)NCCN3CCCC3)C4=CC=C(CN5CCOCC5)C=C4",3.737,3,1,7]
["S0272","Derenofylline (SLV320)","f9","L3900-35","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Derenofylline (SLV320) is a selective and potent adenosine A1 antagonist with Ki of 1 nM. Derenofylline shows selective for adenosine A1 over A2A, A2B, and A3 receptors with Ki of 398 nM, 3981 nM, and 200 nM, respectively.",308.38,"251945-92-3",{"v":62,"d":"62.00"},201.05,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/derenofylline.html","C18H20N4O","Free Base","N/A","OC1CCC(CC1)NC2=NC(=NC3=C2C=C[NH]3)C4=CC=CC=C4",3.133,2,3,3]
["S0326","Olodanrigan (EMA401)","g9","L3900-35","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.",507.58,"1316755-16-4",{"v":100,"d":"100.00"},197.01,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ema401.html","C32H29NO5","Free Base","PD-126055, (S) PD-126055","COC1=C(OCC2=CC=CC=C2)C3=C(CN(C(C3)C(O)=O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C=C1",5.599,4,0,8]
["S0343","Eprotirome (KB2115)","h9","L3900-35","in 10mM DMSO","THR","Metabolism","Eprotirome (KB2115) is a liver-selective agonist of thyroid hormone receptor (TR). Eprotirome is investigated for the potential treatment of dyslipidemias and obesity.",487.14,"355129-15-6",{"v":97,"d":"97.00"},199.12,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/eprotirome.html","C18H17Br2NO5","Free Base","N/A","CC(C)C1=C(O)C=CC(=C1)OC2=C(Br)C=C(NC(=O)CC(O)=O)C=C2Br",{"v":4.77,"d":"4.770"},3,2,6]
["S0472","EC330","a10","L3900-35","in 10mM DMSO","Interleukins","Immunology & Inflammation","EC330 is a steroidal inhibitor of leukemia inhibitory factor (LIF, an interleukin 6 class cytokine). EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.",462.57,"2016795-77-8",{"v":12,"d":"12.00"},25.94,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ec330.html","C30H32F2O2","Free Base","N/A","CC12CC(C3=CC=C(C=C3)C4CC4)C5=C6CCC(=O)C=C6CCC5C1CCC2(O)C(F)(F)C#C",6.858,1,0,3]
["S0993","Remogliflozin etabonate (GSK189075)","b10","L3900-35","in 10mM DMSO","SGLT","GPCR & G Protein","Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models.",522.59,"442201-24-3",{"v":100,"d":"100.00"},191.35,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/remogliflozin-etabonate.html","C26H38N2O9","Free Base","N/A","CCOC(=O)OCC1OC(OC2=N[N](C(C)C)C(=C2CC3=CC=C(OC(C)C)C=C3)C)C(O)C(O)C1O",3.774,7,3,12]
["S3566","Cerdulatinib (PRT062070)","c10","L3900-35","in 10mM DMSO","JAK,Syk","JAK/STAT","Cerdulatinib (PRT062070, PRT2070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively, also inhibits19 other tested kinases with IC50 less than 200 nM.",445.54,"1198300-79-6",{"v":89,"d":"89.00"},199.76,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/cerdulatinib.html","C20H27N7O3S","Free Base","PRT2070","CC[S](=O)(=O)N1CCN(CC1)C2=CC=C(NC3=NC=C(C(N)=O)C(=N3)NC4CC4)C=C2",{"v":1.48,"d":"1.480"},5,3,8]
["S3572","BMS-986020","d10","L3900-35","in 10mM DMSO","LPA Receptor","GPCR & G Protein","BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).",482.53,"1257213-50-5",{"v":97,"d":"97.00"},201.02,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/bms-986020.html","C29H26N2O5","Free Base","AM152, AP-3152 free acid","CC(OC(=O)NC1=C(ON=C1C)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(O)=O)C5=CC=CC=C5",5.791,5,1,8]
["S4485","Olodaterol (BI 1744)","e10","L3900-35","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Olodaterol (BI 1744) is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).",386.44,"868049-49-4",{"v":77,"d":"77.00"},199.25,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/olodaterol-bi-1744-.html","C21H26N2O5","Free Base","N/A","COC1=CC=C(CC(C)(C)NCC(O)C2=C3OCC(=O)NC3=CC(=C2)O)C=C1",1.875,3,4,7]
["S5899","(R)-(-)-Ibuprofen","f10","L3900-35","in 10mM DMSO","NF-κB","NF-κB","(R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM, and exerts anti-inflammatory and antinociceptive effects.",206.28,"51146-57-7",{"v":41,"d":"41.00"},198.76,{"v":41,"d":"41.00"},198.76,"http://www.selleckchem.com/products/-r-ibuprofen.html","C13H18O2","Free Base","(R)-Ibuprofen","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S5980","Losartan Carboxylic Acid (EXP-3174)","g10","L3900-35","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.",436.89,"124750-92-1",{"v":87,"d":"87.00"},199.13,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/losartan-carboxylic-acid-exp-3174-.html","C22H21ClN6O2","Free Base","E-3174","CCCCC1=NC(=C([N]1CC2=CC=C(C=C2)C3=CC=CC=C3C4=N[NH]N=N4)C(O)=O)Cl",5.129,5,1,8]
["S6214","H-1152 dihydrochloride","h10","L3900-35","in 10mM DMSO","Aurora Kinase,CaMK,PKA,PKC,PKG,ROCK","Cell Cycle","H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.",392.34,"871543-07-6",{"v":78,"d":"78.00"},198.81,{"v":78,"d":"78.00"},198.81,"http://www.selleckchem.com/products/h-1152-dihydrochloride.html","C16H23Cl2N3O2S","Dihydrochloride","H-1152 2HCl","Cl.Cl.CC1CNCCCN1[S](=O)(=O)C2=CC=CC3=C2C(=CN=C3)C",1.816,3,1,2]
["S6239","PMX-53","a11","L3900-35","in 10mM DMSO","CD markers,Immunology & Inflammation related","Immunology & Inflammation","PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).",896.09,"219639-75-5",{"v":100,"d":"100.00"},{"v":111.6,"d":"111.60"},{"v":10,"d":"10.00"},11.16,"http://www.selleckchem.com/products/pmx-53.html","C47H65N11O7","Free Base","N/A","CC(=O)NC(CC1=CC=CC=C1)C(=O)NC2CCCNC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(CC5CCCCC5)NC(=O)C6CCCN6C2=O",2.032,8,9,13]
["S6304","KL001","b11","L3900-35","in 10mM DMSO","Others","Others","KL001 is a stabilizer that specifically interacts with cryptochrome (CRY). KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period.",398.48,"309928-48-1",{"v":80,"d":"80.00"},200.76,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/kl001.html","C21H22N2O4S","Free Base","N/A","C[S](=O)(=O)N(CC(O)C[N]1C2=CC=CC=C2C3=CC=CC=C13)CC4=CC=CO4",2.972,3,1,7]
["S6387","Cilengitide","c11","L3900-35","in 10mM DMSO","Integrin","Cytoskeletal Signaling","Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-​707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively.",588.66,"188968-51-6",{"v":100,"d":"100.00"},169.88,{"v":100,"d":"100.00"},169.88,"http://www.selleckchem.com/products/cilengitide.html","C27H40N8O7","Free Base","EMD 121974, EMD-12192, EMD-85189, NSC-​707544","CC(C)C1N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC1=O",-1.448,6,6,10]
["S6390","Y-27632","d11","L3900-35","in 10mM DMSO","ROCK","Cell Cycle","Y-27632 is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",247.34,"146986-50-7",{"v":49,"d":"49.00"},198.11,"<1",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/y-27632-rock.html","C14H21N3O","Free Base","N/A","CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.107,2,2,3]
["S6391","Sephin-1","e11","L3900-35","in 10mM DMSO","phosphatase","Metabolism","Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A.",196.64,"951441-04-6",{"v":39,"d":"39.00"},198.33,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/sephin-1.html","C8H9ClN4","Free Base","NSC-65390","NC(=N)N\\N=C\\C1=CC=CC=C1Cl",1.528,1,2,3]
["S6884","LY3405105","f11","L3900-35","in 10mM DMSO","CDK","Cell Cycle","LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity.",497.63,"2326428-25-3",{"v":99,"d":"99.00"},198.94,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ly3405105.html","C26H39N7O3","Free Base","N/A","CC(C)C1=C2N=C(C)C=C(NC3CCN(CC3)C(=O)OC4CCN(C4)C(=O)\\C=C\\CN(C)C)[N]2N=C1",1.936,5,1,8]
["S6965","Bavdegalutamide (ARV-110)","g11","L3900-35","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.",812.29,"2222112-77-6",{"v":100,"d":"100.00"},123.11,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/arv-110.html","C41H43ClFN9O6","Free Base","N/A","FC1=CC2=C(C=C1N3CCN(CC3)CC4CCN(CC4)C5=NN=C(C=C5)C(=O)NC6CCC(CC6)OC7=CC=C(C#N)C(=C7)Cl)C(=O)N(C8CCC(=O)NC8=O)C2=O",4.677,8,2,9]
["S6981","Glycerol phenylbutyrate","h11","L3900-35","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.",530.65,"611168-24-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/glycerol-phenylbutyrate.html","C33H38O6","Free Base","GT4P, HPN-100M, Ravicti","O=C(CCCC1=CC=CC=C1)OCC(COC(=O)CCCC2=CC=CC=C2)OC(=O)CCCC3=CC=CC=C3",7.563,6,0,20]
["S6985","Varenicline","a2","L3900-36","in 10mM DMSO","AChR","Neuronal Signaling","Varenicline(CP 526555) is highly selective and blocks more potently to α4β2 receptors than to other common nicotinic receptors (>500-fold α3β4, >3,500-fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (>2,000-fold). Varenicline also acts as an agonist of 5-HT3 serotonine receptors.",211.26,"249296-44-4",{"v":42,"d":"42.00"},198.81,{"v":3,"d":"3.00"},{"v":14.2,"d":"14.20"},"http://www.selleckchem.com/products/varenicline.html","C13H13N3","Free Base","Chantix, Champix,CP 526555","C1NCC2CC1C3=CC4=NC=CN=C4C=C23",1.038,2,1,0]
["S7647","Lucitanib (E3810) hydrochloride","b2","L3900-36","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Lucitanib (E-3810, AL3810) hydrochloride is a dual inhibitor of Vascular endothelial growth factor receptor (VEGFR) and Fibroblast growth factor receptor (FGFR). Lucitanib hydrochloride (E-3810, AL3810) potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50 of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.",479.96,"1058137-23-7",{"v":59,"d":"59.00"},122.93,{"v":59,"d":"59.00"},122.93,"http://www.selleckchem.com/products/lucitanib.html","C26H26ClN3O4","Hydrochloride","AL3810","[Cl-].CNC(=O)C1=CC=CC2=C1C=CC(=C2)OC3=CC=NC4=CC(=C(OC)C=C34)OCC5([NH3+])CC5",-0.502,5,1,7]
["S7848","QX-314 chloride","c2","L3900-36","in 10mM DMSO","Sodium Channel,TRP Channel","Transmembrane Transporters","QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.",298.85,"5369-03-9",{"v":60,"d":"60.00"},200.77,{"v":60,"d":"60.00"},200.77,"http://www.selleckchem.com/products/qx-314-chloride.html","C16H27ClN2O","Chloride","N/A","[Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C",-1.054,1,1,6]
["S8668","Inavolisib (GDC-0077)","d2","L3900-36","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.",407.37,"2060571-02-8",{"v":81,"d":"81.00"},198.84,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/gdc-0077.html","C18H19F2N5O4","Free Base","RG6114, RO-7113755","CC(NC1=CC=C2C(=C1)OCC[N]3C=C(N=C23)N4C(COC4=O)C(F)F)C(N)=O",1.666,5,2,5]
["S8996","Revumenib","e2","L3900-36","in 10mM DMSO","MLL","Epigenetics","Revumenib(SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.",630.82,"2169919-21-3",{"v":25,"d":"25.00"},39.63,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/sndx-5613.html","C32H47FN6O4S","Free Base","SNDX-5613","CCN(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](=O)(=O)CC)C3)C=CC(=C1)F",{"v":4.06,"d":"4.060"},6,1,11]
["S9729","Visomitin (SKQ1)","f2","L3900-36","in 10mM DMSO","Others","Others","Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells.",{"v":617.6,"d":"617.60"},"934826-68-3","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/visomitin-skq1.html","C36H42BrO2P","Free Base","N/A","[Br-].CC1=C(C)C(=O)C(=CC1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4",7.986,2,0,14]
["S9776","AG-636","g2","L3900-36","in 10mM DMSO","Dehydrogenase","Metabolism","AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.",343.38,"1623416-31-8",{"v":35,"d":"35.00"},101.93,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ag-636.html","C21H17N3O2","Free Base","N/A","C[N]1N=NC2=CC(=CC(=C12)C(O)=O)C3=CC=C(C=C3)C4=CC=CC=C4C",4.793,3,0,3]
["S9779","Emavusertib (CA-4948)","h2","L3900-36","in 10mM DMSO","FLT3,IRAK","Immunology & Inflammation","Emavusertib (CA-4948) is a potent and orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3) with anti-tumor activity.",{"v":491.5,"d":"491.50"},"1801344-14-8",{"v":49,"d":"49.00"},99.69,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/ca-4948.html","C24H25N7O5","Free Base","N/A","CC1=NC=CC(=C1)C2=NC(=CO2)C(=O)NC3=C(N=C4N=C(OC4=C3)N5CCOCC5)N6CCC(O)C6",1.031,8,2,5]
["S9832","CC-90009","a3","L3900-36","in 10mM DMSO","E3 Ligase","Ubiquitin","CC-90009 is a novel cereblon (CRBN) E3 ligase modulator and specifically targets GSPT1 (G1 to S phase transition 1) for proteasomal degradation.",461.85,"1860875-51-9",{"v":44,"d":"44.00"},95.27,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/cc-90009.html","C22H18ClF2N3O4","Free Base","N/A","FC(F)(C(=O)NCC1=CC2=C(C=C1)C(=O)N(C2)C3CCC(=O)NC3=O)C4=CC=C(Cl)C=C4",2.179,4,2,5]
["S9851","Danuglipron (PF-06882961)","b3","L3900-36","in 10mM DMSO","Glucagon Receptor","GPCR & G Protein","Danuglipron (PF-06882961), a non-peptide agonist, activates the canonical G protein signaling activity only in the Glucagon-like peptide-1 (GLP-1) receptor with Trp33ECD.",{"v":555.6,"d":"555.60"},"2230198-02-2",{"v":10,"d":"10.00"},{"v":18,"d":"18.00"},"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pf-06882961.html","C31H30FN5O4","Free Base","N/A","OC(=O)C1=CC=C2N=C(CN3CCC(CC3)C4=NC(=CC=C4)OCC5=C(F)C=C(C=C5)C#N)[N](CC6CCO6)C2=C1",1.651,5,0,9]
["S9870","STM2457","c3","L3900-36","in 10mM DMSO","Transferase","Metabolism","STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50  of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.",444.53,"2499663-01-1",{"v":89,"d":"89.00"},200.21,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/stm2457.html","C25H28N6O2","Free Base","N/A","O=C(NCC1=C[N]2C=C(CNCC3CCCCC3)C=CC2=N1)C4=CC(=O)N5C=CC=CC5=N4",1.465,4,2,7]
["S9885","MYLS22","d3","L3900-36","in 10mM DMSO","Others","Others","MYLS22  is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) with anti-angiogenesis and anti-cancer activity.",443.52,"306959-01-3",{"v":81,"d":"81.00"},182.63,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/myls22.html","C24H21N5O2S","Free Base","N/A","CN1N(C(=O)C(=C1C)NC(=O)C2=CC3=C(S2)[N](N=C3C)C4=CC=CC=C4)C5=CC=CC=C5",3.247,3,1,4]
["S9900","JNJ-63576253 (TRC-253)","e3","L3900-36","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM.  JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.",538.97,"2110428-64-1",{"v":100,"d":"100.00"},185.54,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/jnj-63576253-trc-253.html","C23H22ClF3N6O2S","Free Base","N/A","Cl.FC(F)(F)C1=CC(=CN=C1C#N)N2C(=O)C3(CCC3)N(C2=S)C4=CN=C(OC5CCNCC5)C=C4",4.367,4,1,5]
["S9919","Pimonidazole","f3","L3900-36","in 10mM DMSO","Others","Others","Pimonidazole (Ro 03-8799) is a novel hypoxia marker used for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.",254.29,"70132-50-2",{"v":51,"d":"51.00"},200.56,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pimonidazole.html","C11H18N4O3","Free Base","Ro 03-8799","OC(CN1CCCCC1)C[N]2C=CN=C2[N+]([O-])=O",0.904,1,1,5]
["S9948","Danicamtiv (MYK-491)","g3","L3900-36","in 10mM DMSO","Cardiac Myosin","Cytoskeletal Signaling","Danicamtiv (MYK-491, SAR 440181) is a novel cardiac myosin activator that enhances cardiomyocyte contraction.",435.42,"1970972-74-7",{"v":87,"d":"87.00"},199.81,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/danicamtiv-myk-491.html","C16H20F3N5O4S","Free Base","SAR 440181","C[N]1C=C(C(=N1)C(F)F)[S](=O)(=O)C(C)(F)C2CCN(CC2)C(=O)NC3=NOC=C3",1.568,6,1,5]
["E0018","Triheptanoin","h3","L3900-36","in 10mM DMSO","Others","Others","Triheptanoin (API, IND106011, UX007, Glycerol trienanthate) is a synthetic, medium-chain triglyceride consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin is used for treatment of fatty acid oxidation disorders and GLUT1.",{"v":428.6,"d":"428.60"},"620-67-7","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/triheptanoin.html","C24H44O6","Free Base","IND106011, UX007, Glycerol trienanthate","CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC",7.204,6,0,23]
["E0019","Dipivefrin Hydrochloride","a4","L3900-36","in 10mM DMSO","Others","Others","Dipivefrin (Dipivefrine,  Propine, Pivalephrine) is a prodrug of epinephrine which is hydrolyzed to epinephrine after absorption into the eye.",{"v":387.9,"d":"387.90"},"64019-93-8",{"v":78,"d":"78.00"},201.08,{"v":78,"d":"78.00"},201.08,"http://www.selleckchem.com/products/dipivefrin-hydrochloride.html","C19H30ClNO5","Hydrochloride","Dipivefrine,  Propine, Pivalephrine","Cl.CNCC(O)C1=CC(=C(OC(=O)C(C)(C)C)C=C1)OC(=O)C(C)(C)C",3.866,4,2,9]
["E0025","2-Hydroxybenzylamine","b4","L3900-36","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress.",123.15,"932-30-9",{"v":25,"d":"25.00"},{"v":203,"d":"203.00"},{"v":4,"d":"4.00"},32.48,"http://www.selleckchem.com/products/2-hydroxybenzylamine.html","C7H9NO","Free Base","2-(Aminomethyl)phenol, 2-HOBA,  NSC 127870","NCC1=CC=CC=C1O",0.693,0,2,1]
["E0032","Olesoxime (TRO 19622)","c4","L3900-36","in 10mM DMSO","Mitochondrial Metabolism","Metabolism","Olesoxime (TRO19622) is a novel, orally active and CNS-penetrant mitochondrial-targeted neuroprotective compound.",399.65,"22033-87-0",{"v":80,"d":"80.00"},200.18,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/olesoxime-tro-19622.html","C27H45NO","Free Base","N/A","CC(C)CCCC(C)C1CCC2C3CCC4=CC(/CCC4(C)C3CCC12C)=N/O",7.678,1,0,5]
["S0019","JNJ-10229570","d4","L3900-36","in 10mM DMSO","Melanocortin Receptor","GPCR & G Protein","JNJ-10229570 (UNII-N9IX402L35) is a potent MC1R and MC5R antagonist.",389.47,"524923-88-4",{"v":78,"d":"78.00"},200.27,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/jnj-10229570.html","C22H19N3O2S","Free Base","UNII-N9IX402L35","COC1=CC=CC=C1N2SC(=NC3=CC=CC=C3)N=C2C4=CC=CC=C4OC",{"v":5.67,"d":"5.670"},4,0,5]
["S0536","Ibrolipim","e4","L3900-36","in 10mM DMSO","Lipase","Metabolism","Ibrolipim (NO-1886) is an effective lipoprotein lipase (LPL) activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.",451.25,"133208-93-2",{"v":90,"d":"90.00"},199.45,"<1","N/A","http://www.selleckchem.com/products/Ibrolipim-no-1886.html","C19H20BrN2O4P","Free Base","NO-1886","CCO[P](=O)(CC1=CC=C(C=C1)C(=O)NC2=CC=C(Br)C=C2C#N)OCC",{"v":3.19,"d":"3.190"},3,1,8]
["S0874","Vonafexor (EYP001)","f4","L3900-36","in 10mM DMSO","FXR","Metabolism","Vonafexor (EYP001, PLX007) is a novel non-bile acid, selective, second generation farnesoid X receptor (FXR) agonist.",489.76,"1192171-69-9",{"v":98,"d":"98.00"},{"v":200.1,"d":"200.10"},"<1","N/A","http://www.selleckchem.com/products/vonafexor.html","C19H15Cl3N2O5S","Free Base","PLX007","OC(=O)C1=CC2=C(O1)C=CC(=C2Cl)N3CCN(CC3)[S](=O)(=O)C4=C(Cl)C=CC=C4Cl",{"v":4.79,"d":"4.790"},4,0,4]
["S1335","VX-150","g4","L3900-36","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","VX-150 (EOS-62073) is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold).",516.34,"1793080-72-4",{"v":100,"d":"100.00"},193.67,"<1","N/A","http://www.selleckchem.com/products/vx-150.html","C21H17F4N2O7P","Free Base","EOS-62073","CC1=C(OC2=C(C=CC(=C2)C(F)(F)F)C(=O)NC3=CC(=O)N(CO[P](O)(O)=O)C=C3)C=CC(=C1)F",{"v":2.94,"d":"2.940"},4,1,8]
["S2963","WS-12","h4","L3900-36","in 10mM DMSO","TRP Channel","Transmembrane Transporters","WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.",289.41,"68489-09-8",{"v":58,"d":"58.00"},200.41,"<1","N/A","http://www.selleckchem.com/products/ws-12.html","C18H27NO2","Free Base","N/A","COC1=CC=C(NC(=O)C2CC(C)CCC2C(C)C)C=C1",{"v":4.27,"d":"4.270"},2,1,4]
["S6694","Grapiprant (CJ-023,423)","a5","L3900-36","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively.",491.61,"415903-37-6",{"v":98,"d":"98.00"},199.35,"<1","N/A","http://www.selleckchem.com/products/grapiprant-cj-023423.html","C26H29N5O3S","Free Base","AT-001, AAT-007, RQ-00000007, CJ-23423","CCC1=NC2=C(C=C(C)N=C2C)[N]1C3=CC=C(CCNC(=O)N[S](=O)(=O)C4=CC=C(C)C=C4)C=C3",{"v":4.55,"d":"4.550"},5,2,7]
["S6764","Pamufetinib (TAS-115)","b5","L3900-36","in 10mM DMSO","c-Met,VEGFR","Protein Tyrosine Kinase","Pamufetinib (TAS-115) is a highly potent c-Met and VEGFR dual inhibitor with IC50s of 30 nM and 32 nM for recombinant VEGFR2 and recombinant MET, respectively.",518.56,"1190836-34-0",{"v":50,"d":"50.00"},96.42,"<1","N/A","http://www.selleckchem.com/products/tas-115.html","C27H23FN4O4S","Free Base","N/A","CNC(=O)C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(=S)NC(=O)CC4=CC=CC=C4)C=C3F)C2=C1",{"v":4.94,"d":"4.940"},5,3,9]
["S7371","Fadraciclib (CYC065)","c5","L3900-36","in 10mM DMSO","CDK","Cell Cycle","Fadraciclib (CYC065) is a novel, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50 of 5 nM and 26 nM, respectively.",397.52,"1070790-89-4",{"v":80,"d":"80.00"},201.25,"<1","N/A","http://www.selleckchem.com/products/fadraciclib.html","C21H31N7O","Free Base","N/A","CCC(NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=C(C)C=C(C)N=C3)C(C)O",{"v":3.32,"d":"3.320"},4,3,8]
["S7454","Azemiglitazone (MSDC-0602)","d5","L3900-36","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","Azemiglitazone (MSDC-0602) is a direct mitochondrial pyruvate carrier (MPC) inhibitor that modulates central carbon metabolism in mice and humans.",371.41,"1133819-87-0",{"v":82,"d":"82.00"},220.78,"<1","N/A","http://www.selleckchem.com/products/azemiglitazone-msdc-0602.html","C19H17NO5S","Free Base","N/A","COC1=CC=CC(=C1)C(=O)COC2=CC=C(CC3SC(=O)NC3=O)C=C2",{"v":3.31,"d":"3.310"},5,1,7]
["S9706","OT-82","e5","L3900-36","in 10mM DMSO","NAMPT","Metabolism","OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.",424.47,"1800487-55-1",{"v":85,"d":"85.00"},200.25,"<1","N/A","http://www.selleckchem.com/products/ot-82.html","C26H21FN4O","Free Base","N/A","FC1=CC=C(C=C1)C#CC2=CC(=CC=C2C3=CC=NC=C3)C(=O)NCCCC4=C[NH]N=C4",{"v":4.53,"d":"4.530"},3,2,8]
["S9848","LM11A-31","f5","L3900-36","in 10mM DMSO","Others","Others","LM11A-31 is a small molecule p75NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression.",243.35,"289475-77-0",{"v":49,"d":"49.00"},201.36,{"v":49,"d":"49.00"},201.36,"http://www.selleckchem.com/products/lm11a-31.html","C12H25N3O2","Free Base","N/A","CCC(C)C(N)C(=O)NCCN1CCOCC1",{"v":0.02,"d":"0.020"},2,2,6]
["S9896","JNJ-67856633","g5","L3900-36","in 10mM DMSO","MALT","Proteases","JNJ-67856633 (JNJ-6633) is a potent, selective, allosteric inhibitor of MALT1 protease.",467.32,"2230273-76-2",{"v":93,"d":"93.00"},199.01,"<1","N/A","http://www.selleckchem.com/products/jnj-67856633.html","C20H11F6N5O2","Free Base","JNJ-6633","FC(F)(F)C1=NC=CC(=C1)NC(=O)C2=C([N](N=C2)C3=CC=CC4=C3C=CNC4=O)C(F)(F)F",{"v":3.19,"d":"3.190"},4,2,5]
["S9899","BMS-986299","h5","L3900-36","in 10mM DMSO","NLRP3","Immunology & Inflammation","BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.",349.39,"2242952-69-6",{"v":70,"d":"70.00"},200.35,{"v":17,"d":"17.00"},48.66,"http://www.selleckchem.com/products/bms-986299.html","C18H19N7O","Free Base","N/A","CCN(CC1=NC2=C(N)N=C3C=C(C=CC3=C2[NH]1)C4=N[NH]C=C4)C(C)=O",{"v":1.59,"d":"1.590"},4,3,4]
["E0046","β-Cyclodextrin","a6","L3900-36","in 10mM DMSO","Others","Others","β-Cyclodextrin (β-CD, Beta-Cyclodextrin) is a cyclic derivative of starch prepared from partially hydrolyzed starch (maltodextrin) by an enzymatic process. β-Cyclodextrin can be used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability.",1134.98,"7585-39-9",{"v":100,"d":"100.00"},88.11,{"v":5,"d":"5.00"},4.41,"http://www.selleckchem.com/products/beta-cyclodextrin.html","C42H70O35","Free Base","β-CD, Beta-Cyclodextrin","OCC1OC2OC3C(O)C(O)C(OC3CO)OC4C(O)C(O)C(OC4CO)OC5C(O)C(O)C(OC5CO)OC6C(O)C(O)C(OC6CO)OC7C(O)C(O)C(OC7CO)OC8C(O)C(O)C(OC8CO)OC1C(O)C2O",{"v":-12.23,"d":"-12.230"},14,21,7]
["E0047","Vodobatinib (K0706)","b6","L3900-36","in 10mM DMSO","Bcr-Abl","Angiogenesis","Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.",453.92,"1388803-90-4",{"v":91,"d":"91.00"},200.48,"<1","N/A","http://www.selleckchem.com/products/vodobatinib.html","C27H20ClN3O2","Free Base","SCO-088, SUN K706, SUN-K0706","CC1=C(C=C(C=C1)C(=O)NNC(=O)C2=C(C)C=CC=C2Cl)C#CC3=CC4=CC=CC=C4N=C3",{"v":5.8,"d":"5.800"},3,2,5]
["E0049","Pizuglanstat (TAS-205)","c6","L3900-36","in 10mM DMSO","PGDS","Metabolism","Pizuglanstat (TAS-205) is a highly selective hematopoietic prostaglandin D synthase (HPGDS) inhibitor with an IC50 of 55.8 nM.",508.61,"1244967-98-3",{"v":100,"d":"100.00"},196.61,"<1","N/A","http://www.selleckchem.com/products/pizuglanstat.html","C₂₇H₃₆N₆O₄","Free Base","N/A","C[N]1C=CC=C1C(=O)N2CCN(CC2)C(=O)NC3=CC=C(C=C3)N4CCC(CC4)C(=O)N5CCOCC5",{"v":1.36,"d":"1.360"},4,1,4]
["E0050","Seralutinib (GB002)","d6","L3900-36","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively.",469.54,"1619931-27-9",{"v":94,"d":"94.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://www.selleckchem.com/products/seralutinib-pk10571.html","C27H27N5O3","Free Base","PK10571","COC1=C(OC)C=C(C=C1)C2=CN=CC(=N2)NC(C)C3=CC(=CC=C3)NC(=O)C4=CN=CC(=C4)C",{"v":3.87,"d":"3.870"},6,2,8]
["E0076","Simufilam dihydrochloride","e6","L3900-36","in 10mM DMSO","Actin","Cytoskeletal Signaling","Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.",332.27,"2480226-06-8",{"v":66,"d":"66.00"},198.63,{"v":66,"d":"66.00"},198.63,"http://www.selleckchem.com/products/simufilam-dihydrochloride.html","C15H23Cl2N3O","Dihydrochloride","PTI-125 dihydrochloride","Cl.Cl.CN1CCC2(CC1)NCC(=O)N2CC3=CC=CC=C3",{"v":1.86,"d":"1.860"},1,1,2]
["E0084","Fluorofenidone","f6","L3900-36","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","Fluorofenidone (AKF-PD) inhibits nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Fluorofenidone also attenuates BLM-induced pulmonary inflammation and fibrosis through suppressing the activation of NALP3 inflammasome and the IL-1β/IL-1R1/MyD88/NF-κB signalling pathway.",203.21,"848353-85-5",{"v":41,"d":"41.00"},201.76,"<1","N/A","http://www.selleckchem.com/products/fluorofenidone.html","C12H10FNO","Free Base","AKF-PD","CC1=CN(C(=O)C=C1)C2=CC(=CC=C2)F",{"v":2.11,"d":"2.110"},1,0,1]
["E0122","Gemigliptin","g6","L3900-36","in 10mM DMSO","DPP","Proteases","Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.",489.36,"911637-19-9",{"v":98,"d":"98.00"},200.26,{"v":12,"d":"12.00"},24.52,"http://www.selleckchem.com/products/gemigliptin.html","C18H19F8N5O2","Free Base","Zemiglo, LC15-0444","NC(CN1CC(F)(F)CCC1=O)CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F",{"v":1.29,"d":"1.290"},4,1,6]
["E0136","N-Nitrosodiethylamine","h6","L3900-36","in 10mM DMSO","Others","Others","N-Nitrosodiethylamine (N-Nitroso-diethylamine, NDEA, diethylnitrosamine, DEN) is DNA reactive after bioactivation and produces tumors in many animal species.",102.14,"55-18-5","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","http://www.selleckchem.com/products/n-nitrosodiethylamine.html","C4H10N2O","Free Base","N-Nitroso-diethylamine, NDEA, diethylnitrosamine, DEN","CCN(CC)N=O",{"v":0.79,"d":"0.790"},1,0,3]
["E0141","Bexagliflozin (EGT1442)","a7","L3900-36","in 10mM DMSO","SGLT","GPCR & G Protein","Bexagliflozin (EGT1442, EGT-0001442, THR-1442) is a potent and selective SGLT2 inhibitor with an IC50 of 2 nM.",464.94,"1118567-05-7",{"v":93,"d":"93.00"},200.03,{"v":93,"d":"93.00"},200.03,"http://www.selleckchem.com/products/bexgliflozin-egt1442.html","C24H29ClO7","Free Base","EGT-0001442, THR-1442","OCC1OC(C(O)C(O)C1O)C2=CC(=C(Cl)C=C2)CC3=CC=C(OCCOC4CC4)C=C3",{"v":2.42,"d":"2.420"},3,4,9]
["E0154","Taurocholic acid sodium salt","b7","L3900-36","in 10mM DMSO","Others","Others","Taurocholic acid sodium salt (Sodium Taurocholate, TANa) is a sodium salt of taurocholic acid and occurs in the bile of mammals. Taurocholic acid  is used as a cholagogue and choleretic.",537.68,"145-42-6",{"v":100,"d":"100.00"},185.98,{"v":100,"d":"100.00"},185.98,"http://www.selleckchem.com/products/taurocholic-acid-sodium-salt.html","C26H45NO7S.Na","Sodium salt","Sodium Taurocholate, TANa","[Na+].CC(CCC(=O)NCC[S]([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C",{"v":-0.35,"d":"-0.350"},1,4,7]
["E0314","JTE-607 Dihydrochloride","c7","L3900-36","in 10mM DMSO","Interleukins,TNF-alpha","Apoptosis","JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.",597.36,"188791-09-5",{"v":100,"d":"100.00"},{"v":167.4,"d":"167.40"},{"v":100,"d":"100.00"},{"v":167.4,"d":"167.40"},"http://www.selleckchem.com/products/jte-607-dihydrochloride.html","C25H31Cl2N3O5.2ClH","Dihydrochloride","N/A","Cl.Cl.CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(OCCN3CCN(C)CC3)C(=C2O)Cl)Cl",{"v":5.06,"d":"5.060"},4,2,11]
["E0368","Sunvozertinib","d7","L3900-36","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations with IC50 ranging from 0.4 nM to 2.1 nM for mutant EGFR.",584.08,"2370013-49-1",{"v":100,"d":"100.00"},171.21,"<1","N/A","http://www.selleckchem.com/products/dzd9008.html","C29H35ClFN7O3","Free Base","DZD9008","COC1=C(NC2=NC=CC(=N2)NC3=CC(=C(F)C=C3C(C)(C)O)Cl)C=C(NC(=O)C=C)C(=C1)N4CCC(C4)N(C)C",{"v":5.07,"d":"5.070"},4,3,10]
["E1003","Aminopterin","e7","L3900-36","in 10mM DMSO","DHFR","Metabolism","Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.",440.41,"54-62-6",{"v":88,"d":"88.00"},199.81,"<1","N/A","http://www.selleckchem.com/products/aminopterin.html","C19H20N8O5","Free Base","4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739","NC1=NC(=C2N=C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1)N",{"v":-0.24,"d":"-0.240"},7,4,9]
["S0007","RO 5028442 (RG7713)","f7","L3900-36","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","RO 5028442 (RG7713) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM for hV1a and 39 nM for mV1a.",437.96,"920022-47-5",{"v":5,"d":"5.00"},11.42,"<1","N/A","http://www.selleckchem.com/products/ro-5028442-rg7713.html","C25H28ClN3O2","free base","N/A","CN(C)CC[N]1C=C(C(=O)N2CCC3(CC2)OCC4=C3C=CC=C4)C5=C1C=C(Cl)C=C5",{"v":3.58,"d":"3.580"},2,0,4]
["S0009","Asimadoline hydrochloride","g7","L3900-36","in 10mM DMSO","Opioid Receptor","GPCR & G Protein","Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).",{"v":451,"d":"451.00"},"185951-07-9",{"v":90,"d":"90.00"},199.56,{"v":3,"d":"3.00"},6.65,"http://www.selleckchem.com/products/asimadoline.html","C27H30N2O2.ClH","hydrochloride","EMD-61753 hydrochloride","Cl.CN(C(CN1CCC(O)C1)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4",4.276,1,1,7]
["S0017","Lu-135252","h7","L3900-36","in 10mM DMSO","Endothelin Receptor","GPCR & G Protein","Lu-135252 (Darusentan,HMR-4005) is a selective endothelin A receptor (ET-A receptor) antagonist indicated for the oral treatment of resistant hypertension.",410.42,"171714-84-4",{"v":82,"d":"82.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/lu-135252.html","C22H22N2O6","free base","Darusentan, HMR-4005","COC1=NC(=NC(=C1)OC)OC(C(O)=O)C(OC)(C2=CC=CC=C2)C3=CC=CC=C3",4.139,7,0,9]
["S0026","GET-73","a8","L3900-36","in 10mM DMSO","Others","Neuronal Signaling","GET-73(Gamma hydroxybutyric acid analogue,GET 73,GHB analogue), a γ-hydroxybutyrate (GHB) analog, shows a neuroprotective role against ethanol-induced neurotoxicity in primary cultures of rat hippocampal neurons.",275.27,"202402-01-5",{"v":55,"d":"55.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/get-73.html","C13H16F3NO2","free base","Gamma hydroxybutyric acid analogue, GET 73, GHB analogue","COCCCC(=O)NCC1=CC=C(C=C1)C(F)(F)F",2.205,2,1,7]
["S0111","Taprenepag","b8","L3900-36","in 10mM DMSO","Prostaglandin Receptor","Immunology & Inflammation","Taprenepag(CP-544326) is a potent and selective prostaglandin EP2 agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively.",478.52,"752187-80-7",{"v":96,"d":"96.00"},200.62,"<1","N/A","http://www.selleckchem.com/products/cp544326.html","C24H22N4O5S","free base","CP-544326","OC(=O)COC1=CC=CC(=C1)CN(CC2=CC=C(C=C2)[N]3C=CC=N3)[S;v6](=O)(=O)C4=CN=CC=C4",2.655,6,0,10]
["S0190","Lotamilast (RVT-501)","c8","L3900-36","in 10mM DMSO","PDE","Metabolism","Lotamilast (RVT-501, E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.",472.49,"947620-48-6",{"v":94,"d":"94.00"},198.95,"<1","N/A","http://www.selleckchem.com/products/e6005.html","C26H24N4O5","free base","E6005","CNC1=NC(=C2C=C(OC)C(=CC2=N1)OC)C3=CC(=CC=C3)NC(=O)C4=CC=C(C=C4)C(=O)OC",4.272,7,2,8]
["S0282","YL 0919","d8","L3900-36","in 10mM DMSO","5-HT Receptor,5-HT Receptor","Neuronal Signaling","YL0919, a novel structure compound, exerts dual effect on the serotonergic system, as both 5-hydroxytryptamine receptor 1A (5-HT1A) agonist and 5-HT uptake blocker, showing remarkable antidepressant effects in animal models.",334.84,"1339058-04-6",{"v":67,"d":"67.00"},{"v":200.1,"d":"200.10"},"<1","N/A","http://www.selleckchem.com/products/yl-0919.html","C18H22N2O2.ClH","hydrochloride","N/A","Cl.OC1(CCN(CC1)CC2=CC=CC=C2)CN3C=CC=CC3=O",1.275,1,0,4]
["S0312","Rimeporide","e8","L3900-36","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Rimeporide(EMD-87580) is a sodium hydrogen exchanger (NHE-1) inhibitor indicated for patients with Duchenne muscular dystrophy.",333.38,"187870-78-6",{"v":67,"d":"67.00"},200.97,"<1","N/A","http://www.selleckchem.com/products/rimeporide.html","C11H15N3O5S2","free base","EMD-87580","CC1=CC(=C(C=C1C(=O)NC(N)=N)[S](C)(=O)=O)[S](C)(=O)=O",0.204,5,2,4]
["S0318","Ansofaxine hydrochloride","f8","L3900-36","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Ansofaxine hydrochloride (LY03005, LPM570065), a triple reuptake inhibitor, inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.",417.97,"916918-84-8",{"v":84,"d":"84.00"},200.97,{"v":3,"d":"3.00"},7.18,"http://www.selleckchem.com/products/ansofaxine-hydrochloride.html","C24H31NO3.ClH","hydrochloride","LY03005, LPM570065","Cl.CN(C)CC(C1=CC=C(OC(=O)C2=CC=C(C)C=C2)C=C1)C3(O)CCCCC3",5.338,2,0,7]
["S0320","Cycloguanil hydrochloride","g8","L3900-36","in 10mM DMSO","Anti-infection","Microbiology","Cycloguanil hydrochloride, an active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.",288.18,"152-53-4",{"v":58,"d":"58.00"},201.26,{"v":15,"d":"15.00"},52.05,"http://www.selleckchem.com/products/cycloguanil-hydrochloride.html","C11H14ClN5.ClH","hydrochloride","N/A","Cl.CC1(C)N=C(N)N=C(N)N1C2=CC=C(Cl)C=C2",2.005,2,2,1]
["S0388","SD169","h8","L3900-36","in 10mM DMSO","p38 MAPK","MAPK","SD-169(5-Carbamoylindole) is a selective inhibitor of p38α MAPK, which can reduce p38 and HSP60 expression in T cells of the pancreatic beta islets.",160.17,"1670-87-7",{"v":32,"d":"32.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/sd169.html","C9H8N2O","free base","5-Carbamoylindole","NC(=O)C1=CC2=C([NH]C=C2)C=C1",1.125,1,2,1]
["S0418","Ezutromid","a9","L3900-36","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Ezutromid (SMT C1100,BMN 195,VOX-C1100) is a first-in-class, orally active benzoxazole utrophin modulator with an EC50 of 0.91 μM which can be used for the research Duchenne muscular dystrophy (DMD), also inhibits CYP1A2 enzymic activity in human liver microsomes (HLM) with an IC50 of 5.4 μM.",337.39,"945531-77-1",{"v":4,"d":"4.00"},11.86,"<1","N/A","http://www.selleckchem.com/products/ezutromid.html","C19H15NO3S","free base","SMT C1100, BMN 195, VOX-C1100","CC[S;v6](=O)(=O)C1=CC=C2OC(=NC2=C1)C3=CC4=C(C=CC=C4)C=C3",4.063,4,0,3]
["S0452","NP118809","b9","L3900-36","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.",460.61,"41332-24-5",{"v":92,"d":"92.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/np118809.html","C32H32N2O","free base","39-1B4","O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5",6.172,1,0,7]
["S0518","NS 1738","c9","L3900-36","in 10mM DMSO","AChR","GPCR & G Protein","NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), with respect to positive modulation of Xenopus laevis oocyte α7 nAChR with EC50 of 3.4 μM, as well as a comparable efficacy at the rat α7 nAChR with EC50 of 3.9 μM.",365.13,"501684-93-1",{"v":73,"d":"73.00"},199.93,"<1","N/A","http://www.selleckchem.com/products/ns-1738.html","C14H9Cl2F3N2O2","free base","NSC 213859","OC1=CC=C(Cl)C=C1NC(=O)NC2=CC(=CC=C2Cl)C(F)(F)F",4.552,1,3,3]
["S0535","FK962","d9","L3900-36","in 10mM DMSO","Calcium Channel,SSTR","Transmembrane Transporters","FK962, a derivative of FK960 with putative anti-dementia properties, significantly enhances high K+-evoked somatostatin release from rat hippocampal slices at 1-1000 nM, also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons.",{"v":264.3,"d":"264.30"},"283167-06-6",{"v":53,"d":"53.00"},200.53,{"v":2,"d":"2.00"},7.57,"http://www.selleckchem.com/products/fk962.html","C14H17FN2O2","free base","N/A","CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(F)C=C2",0.613,2,1,2]
["S0730","(Rac)-Antineoplaston A10","e9","L3900-36","in 10mM DMSO","Ras","Apoptosis","(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10, which is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.",246.26,"77658-84-5",{"v":49,"d":"49.00"},198.98,"<1","N/A","http://www.selleckchem.com/products/-rac--antineoplaston-a10.html","C13H14N2O3","free base","N/A","O=C1CCC(NC(=O)CC2=CC=CC=C2)C(=O)N1",0.307,3,2,3]
["S0762","SC 236","f9","L3900-36","in 10mM DMSO","COX","Immunology & Inflammation","SC-236 is a potent, selective, orally active inhibitor of COX-2 with an IC50 of 10 nM and approximately 18,000-fold COX-2 selectivity.",401.79,"170569-86-5",{"v":80,"d":"80.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/sc-236.html","C16H11ClF3N3O2S","free base","N/A","N[S](=O)(=O)C1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(Cl)C=C3)C(F)(F)F",4.606,3,1,4]
["S0871","Gusacitinib (ASN-002)","g9","L3900-36","in 10mM DMSO","JAK,Syk","Angiogenesis","Gusacitinib (ASN-002) is a novel and potent dual inhibitor of spleen tyrosine kinase (SYK) and Janus kinases (JAK) with IC50 values of 5-46 nM in biochemical assays.",460.53,"1425381-60-7",{"v":92,"d":"92.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/gusacitinib.html","C24H28N8O2","free base","N/A","OC1CCN(CC1)C2=CC=C(NC3=NC(=NC4=C3C(=O)NN=C4)N5CCC(CC5)CC#N)C=C2",2.467,4,3,5]
["S0893","SB-200646A","h9","L3900-36","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","SB-200646A is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively.",302.76,"143797-62-0",{"v":100,"d":"100.00"},330.29,{"v":3,"d":"3.00"},9.91,"http://www.selleckchem.com/products/sb-200646a.html","C15H14N4O.ClH","hydrochloride","N/A","Cl.C[N]1C=CC2=CC(=CC=C12)NC(=O)NC3=CC=CN=C3",2.253,2,2,2]
["S1239","TAK-960","a10","L3900-36","in 10mM DMSO","PLK","Cell Cycle","TAK-960 is a novel, investigational, orally bioavailable, potent, and selective PLK1 inhibitor that has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1).",{"v":561.6,"d":"561.60"},"1137868-52-0",{"v":13,"d":"13.00"},23.15,"<1","N/A","http://www.selleckchem.com/products/tak-960.html","C27H34F3N7O3","free base","N/A","COC1=C(NC2=NC=C3N(C)C(=O)C(F)(F)CN(C4CCCC4)C3=N2)C=C(F)C(=C1)C(=O)NC5CCN(C)CC5",3.451,5,2,6]
["S1265","SQ109","b10","L3900-36","in 10mM DMSO","Parasite","Microbiology","SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for LLC-MK2 culture-derived trypomastigotes of 50±8 nM, targets MmpL3 (mycobacterial membrane protein large 3) in Mycobacterium tuberculosis.",330.55,"502487-67-4","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/sq109.html","C22H38N2","free base","N/A","CC(C)=CCC/C(C)=C/CNCCNC1C2CC3CC(C2)CC1C3",4.936,0,2,9]
["S2089","Fenoldopam","c10","L3900-36","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Fenoldopam (SKF 82526) is a selective dopamine-1 (DA1) receptor agonist with natriuretic/diuretic properties with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells, which is more potent than DA .",305.76,"67227-56-9",{"v":77,"d":"77.00"},251.83,{"v":10,"d":"10.00"},32.71,"http://www.selleckchem.com/products/fenoldopam-corlopam.html","C16H16ClNO3","free base","SKF 82526","OC1=CC=C(C=C1)C2CNCCC3=C(Cl)C(=C(O)C=C23)O",3.053,0,4,1]
["S2174","Hydroxyflutamide (Hydroxyniphtholide)","d10","L3900-36","in 10mM DMSO","Adrenergic Receptor","Endocrinology & Hormones","Hydroxyflutamide (SCH-16423, Hydroxyniphtholide) is an androgen receptor (AR) antagonist and possesses an IC50 of 0.7 μM for the androgen receptor.",292.21,"52806-53-8",{"v":58,"d":"58.00"},198.49,"<1","N/A","http://www.selleckchem.com/products/hydroxyflutamide-sch-16423-hydroxyniphtholide.html","C11H11F3N2O4","free base","Hydroxy-flutamide, SCH-16423","CC(C)(O)C(=O)NC1=CC=C(C(=C1)C(F)(F)F)[N+]([O-])=O",{"v":1.91,"d":"1.910"},1,1,4]
["S2917","Cutamesine Dihydrochloride","e10","L3900-36","in 10mM DMSO","Sigma Receptor","GPCR & G Protein","Cutamesine dihydrochloride (SA4503 dihydrochloride,AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.",441.43,"165377-44-6",{"v":22,"d":"22.00"},49.84,{"v":88,"d":"88.00"},199.35,"http://www.selleckchem.com/products/sa-4503.html","C23H32N2O2.2HCl","Dihydrochloride","SA4503 dihydrochloride, AGY94806 dihydrochloride","Cl.Cl.COC1=C(OC)C=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1",5.274,2,0,9]
["S2955","NS1652","f10","L3900-36","in 10mM DMSO","Chloride Channel,VRAC","Transmembrane Transporters","NS1652 is a reversible chloride channel blocker, potently inhibits the chloride conductance (IC50 = 1.6 μM) in human and mouse red blood cells, but only weakly volume activated anion conductance (VRAC) (IC50 = 125 μM) in HEK293 cells.",324.25,"1566-81-0",{"v":65,"d":"65.00"},200.46,"<1","N/A","http://www.selleckchem.com/products/ns1652.html","C15H11F3N2O3","free base","N/A","OC(=O)C1=CC=CC=C1NC(=O)NC2=CC=CC(=C2)C(F)(F)F",3.094,2,2,4]
["S2957","Encenicline (EVP-6124) hydrochloride","g10","L3900-36","in 10mM DMSO","AChR","Neuronal Signaling","Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.",{"v":357.3,"d":"357.30"},"550999-74-1",{"v":71,"d":"71.00"},198.71,"<1","N/A","http://www.selleckchem.com/products/encenicline-hydrochloride.html","C16H17ClN2OS.ClH","hydrochloride","N/A","Cl.ClC1=C2SC(=CC2=CC=C1)C(=O)NC3CN4CCC3CC4",3.773,1,1,2]
["S3374","Verubulin hydrochloride","h10","L3900-36","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Verubulin hydrochloride(MPC 6827 hydrochloride) is a microtubule destabilizer and vascular disrupting agent that achieve high brain concentration relative to plasma in animals.",{"v":315.8,"d":"315.80"},"917369-31-4",{"v":56,"d":"56.00"},200.47,{"v":56,"d":"56.00"},200.47,"http://www.selleckchem.com/products/verubulin-hydrochloride.html","C17H18ClN3O","hydrochloride","MPC 6827 hydrochloride","Cl.COC1=CC=C(C=C1)N(C)C2=C3C=CC=CC3=NC(=N2)C",4.004,3,0,3]
["S3532","AN-2718","a11","L3900-36","in 10mM DMSO","Fungal","Microbiology","AN-2718, an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism.",168.39,"174672-06-1",{"v":34,"d":"34.00"},201.91,"<1","N/A","http://www.selleckchem.com/products/an-2718.html","C7H6BClO2","free base","N/A","OB1OCC2=CC(=CC=C12)Cl",2.764,1,0,0]
["S3535","Deudextromethorphan (AVP-786)","b11","L3900-36","in 10mM DMSO","NMDAR","Neuronal Signaling","Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist.",277.43,"1079043-55-2",{"v":55,"d":"55.00"},198.25,{"v":14,"d":"14.00"},50.46,"http://www.selleckchem.com/products/deudextromethorphan-avp-786.html","C18H19D6NO","free base","N/A","C(OC1=CC=C2CC3C4CCCCC4(CCN3C([2H])([2H])[2H])C2=C1)([2H])([2H])[2H]",3.674,1,0,3]
["S3553","Riamilovir","c11","L3900-36","in 10mM DMSO","Antiviral,COVID-19,SARS-CoV","Microbiology","Riamilovir (Triazavirin) is a broad-spectrum antiviral drug candidate, which can be used for potential application against the Coronavirus 2019-nCoV.",228.19,"123606-06-4",{"v":46,"d":"46.00"},201.59,{"v":46,"d":"46.00"},201.59,"http://www.selleckchem.com/products/riamilovir.html","C5H4N6O3S","free base","Triazavirin","CSC1=NC2=NN=C(C(=O)N2N1)[N+]([O-])=O",0.773,4,1,2]
["S3562","Deserpidine","d11","L3900-36","in 10mM DMSO","ACE","Endocrinology & Hormones","Deserpidine (Harmonyl), an alkaloid isolated from the roots of Rauwolfia canescens, is a competitive angiotensin converting enzyme (ACE) inhibitor, also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.",578.65,"131-01-1",{"v":100,"d":"100.00"},172.82,"<1","N/A","http://www.selleckchem.com/products/deserpidine.html","C32H38N2O8","free base","Harmonyl","COC1C(CC2CN3CCC4=C([NH]C5=CC=CC=C45)C3CC2C1C(=O)OC)OC(=O)C6=CC(=C(OC)C(=C6)OC)OC",4.258,8,1,9]
["S5894","Mirodenafil Dihydrochloride","e11","L3900-36","in 10mM DMSO","PDE","Metabolism","Mirodenafil Dihydrochloride(SK-3530 dihydrochloride) is an oral phosphodiesterase type 5 (PDE-5) inhibitor used to treat erectile dysfunction (ED).",604.59,"862189-96-6",{"v":100,"d":"100.00"},{"v":165.4,"d":"165.40"},{"v":1,"d":"1.00"},1.65,"http://www.selleckchem.com/products/mirodenafil-dihydrochloride.html","C26H37N5O5S.2ClH","Dihydrochloride","SK-3530 dihydrochloride","Cl.Cl.CCCOC1=C(C=C(C=C1)[S;v6](=O)(=O)N2CCN(CCO)CC2)C3=NC(=O)C4=C(N3)C(=C[N]4CC)CCC",3.987,5,2,11]
["S6458","Isavuconazonium sulfate","f11","L3900-36","in 10mM DMSO","Anti-infection","Microbiology","Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent, using for invasive aspergillosis and mucormycosis.",814.84,"946075-13-4",{"v":100,"d":"100.00"},122.72,{"v":100,"d":"100.00"},122.72,"http://www.selleckchem.com/products/isavuconazonium-sulfate.html","C35H35F2N8O5S.HO4S","sulfate","BAL8557-002","CNCC(=O)OCC1=C(N=CC=C1)N(C)C(=O)OC(C)[N+]2=C[N](CC(O)(C(C)C3=NC(=CS3)C4=CC=C(C=C4)C#N)C5=C(F)C=CC(=C5)F)N=C2.O[S]([O-])(=O)=O",2.963,7,1,15]
["S7002","Zotiraciclib","g11","L3900-36","in 10mM DMSO","FLT3,JAK","Cell Cycle","Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.",372.46,"937270-47-8",{"v":74,"d":"74.00"},355.41,"<1","N/A","http://www.selleckchem.com/products/sb1317-tg02.html","C23H24N4O","free base","SB1317 (TG02)","CN1C/C=C/CCOC2=CC(=CC=C2)C3=CC=NC(=NC4=CC=CC(=C4)C1)N3",3.296,3,1,0]
["S9892","HM43239","h11","L3900-36","in 10mM DMSO","FLT3","Angiogenesis","HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s' of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.",501.07,"2569527-64-4",{"v":50,"d":"50.00"},99.79,"<1","N/A","http://www.selleckchem.com/products/hm43239.html","C29H33ClN6","free base","N/A","CC1CN(CC(C)N1)CC2=CC(=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=C4C=CC(=C5)C)C6CC6",6.586,2,3,6]
["S9893","Venadaparib(IDX-1197)","a2","L3900-37","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Venadaparib (IDX-1197), a potent PARP1/2 inhibitor with IC50 values of 1.4 nM and 1.0 nM respectively, prevents the repair of DNA single-strand breaks (SSB) and promotes the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells.",406.45,"1681017-83-3",{"v":81,"d":"81.00"},199.29,"<1","N/A","http://www.selleckchem.com/products/venadaparib-idx-1197.html","C23H23FN4O2","free base","N/A","FC1=C(C=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1)C(=O)N4CC(CNC5CC5)C4",{"v":2.12,"d":"2.120"},3,2,6]
["S9934","KA2507","b2","L3900-37","in 10mM DMSO","HDAC","Epigenetics","KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.",322.32,"1636894-46-6",{"v":64,"d":"64.00"},198.56,{"v":64,"d":"64.00"},198.56,"http://www.selleckchem.com/products/ka2507.html","C16H14N6O2","free base","N/A","ONC(=O)C1=CC=C(CN(C2=NC=CN=C2)C3=NC=CN=C3)C=C1",{"v":0.66,"d":"0.660"},5,1,5]
["S9943","ErSO","c2","L3900-37","in 10mM DMSO","Others","ER stress & UPR","ErSO activates the anticipatory unfolded protein response (a-UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro.",453.33,"2407860-35-7",{"v":91,"d":"91.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/erso.html","C22H13F6NO3","free base","N/A","OC1=CC=C(C=C1)C2(C(=O)NC3=C(C=CC=C23)C(F)(F)F)C4=CC=C(OC(F)(F)F)C=C4",6.583,2,2,5]
["S9951","MSDC-0602K Potassium","d2","L3900-37","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","MSDC-0602K is a insulin sensitizer that modulates the mitochondrial pyruvate carrier (MPC).",{"v":409.5,"d":"409.50"},"1314533-27-1",{"v":82,"d":"82.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/msdc-0602k-potassium.html","C19H16NO5S.K","potassium salt","N/A","[K+].COC1=CC=CC(=C1)C(=O)COC2=CC=C(CC3SC(=O)[N-]C3=O)C=C2",3.412,5,0,7]
["S9963","paquinimod","e2","L3900-37","in 10mM DMSO","COVID-19,SARS-CoV","Microbiology","Paquinimod (ABR 25757), a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.",350.41,"248282-01-1",{"v":70,"d":"70.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/paquinimod.html","C21H22N2O3","free base","ABR 25757","CCN(C(=O)C1=C(O)C2=C(CC)C=CC=C2N(C)C1=O)C3=CC=CC=C3",3.162,2,1,4]
["S9973","Flumatinib (HH-GV-678)","f2","L3900-37","in 10mM DMSO","Bcr-Abl,c-Kit,PDGFR","Angiogenesis","Flumatinib (HH-GV-678) is a novel inhibitor of Bcr-Abl with IC50 values of 1.2  nM, 307.6  nM and 665.5  nM for c-Abl, PDGFRβand c-Kit, respectively.",562.59,"895519-90-1",{"v":100,"d":"100.00"},177.75,"<1","N/A","http://www.selleckchem.com/products/flumatinib-hh-gv-678.html","C29H29F3N8O","free base","HH-GV678","CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CN=C(C)C(=C3)NC4=NC(=CC=N4)C5=CN=CC=C5",3.808,5,2,8]
["E0097","Mericitabine","g2","L3900-37","in 10mM DMSO","HCV Protease","Proteases","Mericitabine (RG 7128, R-7128, PSI 6130 diisobutyrate) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.",399.41,"940908-79-2",{"v":80,"d":"80.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://www.selleckchem.com/products/mericitabine.html","C18H26FN3O6","free base","RG 7128, R-7128, PSI 6130 diisobutyrate","CC(C)C(=O)OCC1OC(N2C=CC(=NC2=O)N)C(C)(F)C1OC(=O)C(C)C",1.766,7,1,8]
["E0101","AZD-6280","h2","L3900-37","in 10mM DMSO","GABA Receptor","Transmembrane Transporters","AZD-6280 is a selective GABAA (α2/3) receptor modulator, used for treatment of generalized anxiety disorder.",366.41,"942436-93-3",{"v":73,"d":"73.00"},199.23,"<1","N/A","http://www.selleckchem.com/products/azd-6280.html","C20H22N4O3","free base","N/A","CCCNC(=O)C1=C(N)C2=C(N=N1)C(=CC=C2)C3=C(OC)C=CC(=C3)OC",2.797,5,2,6]
["E0104","Centhaquin","a3","L3900-37","in 10mM DMSO","Others","Neuronal Signaling","Centhaquin (Centhaquine, PMZ-2010), a potential agent for treatment of haemorrhagic shock, can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models.",331.45,"57961-90-7",{"v":33,"d":"33.00"},99.56,"<1","N/A","http://www.selleckchem.com/products/centhaquin.html","C22H25N3","free base","Centhaquine, PMZ-2010","CC1=CC=CC(=C1)N2CCN(CC2)CCC3=NC4=C(C=CC=C4)C=C3",4.668,1,0,4]
["E0117","Deferitrin","b3","L3900-37","in 10mM DMSO","Others","Others","Deferitrin(GT-56-252) is a novel oral iron chelator for the treatment of chronic iron overload due to blood transfusion therapy.",253.28,"239101-33-8",{"v":51,"d":"51.00"},201.36,"<1","N/A","http://www.selleckchem.com/products/deferitrin.html","C11H11NO4S","free base","GT-56-252","CC1(CSC(=N1)C2=CC=C(O)C=C2O)C(O)=O",1.767,2,2,2]
["E0125","Raclopride","c3","L3900-37","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.",347.24,"84225-95-6",{"v":69,"d":"69.00"},198.71,{"v":1,"d":"1.00"},2.88,"http://www.selleckchem.com/products/raclopride.html","C15H20Cl2N2O3","free base","N/A","CCN1CCCC1CNC(=O)C2=C(OC)C(=CC(=C2O)Cl)Cl",3.085,2,2,5]
["E0190","Invert sugar","d3","L3900-37","in 10mM DMSO","Others","Others","Invert Sugar is a popular sweetener.",360.31,"8013-17-0","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/invert-sugar.html","C12H24O12","free base","N/A","OCC(O)C(O)C(O)C(O)C=O.OCC(O)C(O)C(O)C(=O)CO",-5.664,2,10,10]
["E0191","DL-α-tocopherol acetate","e3","L3900-37","in 10mM DMSO","Others","Others","DL-α-Tocopherol acetate (DL-Alpha-tocopherol acetate , Vitamin E acetate), a vitamin E derivative, is used as a vitamin E supplement in poultry feeds.",472.74,"52225-20-4","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/dl-alpha-tocopherol-acetate.html","C31H52O3","free base","DL-Alpha-tocopherol acetate, Vitamin E acetate","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)OC(C)=O",{"v":10.45,"d":"10.450"},3,0,14]
["E0193","Mometasone Furoate Hydrate","f3","L3900-37","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity.",633.51,"141646-00-6",{"v":100,"d":"100.00"},157.85,"<1","N/A","http://www.selleckchem.com/products/mometasone-furoate-hydrate.html","C27H30Cl2O6.H2O","Monohydrate","SCH 32088 hydrate","O.CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(CC2(C)C1(OC(=O)C5=CC=CO5)C(=O)CCl)OC(=O)C6=CC=CO6",5.847,8,0,8]
["E0245","Rhamnose","g3","L3900-37","in 10mM DMSO","Others","Others","Rhamnose(L-Rhamnose) is an important 6-deoxy sugar present in many natural products, glycoproteins, and structural polysaccharides.",164.16,"3615-41-6",{"v":33,"d":"33.00"},201.02,{"v":-1,"d":"-1.00"},-6.09,"http://www.selleckchem.com/products/rhamnose.html","C6H12O5","free base","L-Rhamnose","CC(O)C(O)C(O)C(O)C=O",-1.903,1,4,4]
["E0376","DPPE fumarate","h3","L3900-37","in 10mM DMSO","Others","Others","DPPE fumarate (Tesmilifene fumarate) is a novel potentiator of chemotherapy, which is found to potentiate a wide range of cytotoxics and to protect normal cells.",399.48,"1185241-83-1",{"v":80,"d":"80.00"},200.26,{"v":80,"d":"80.00"},200.26,"http://www.selleckchem.com/products/dppe-fumarate.html","C19H25NO.C4H4O4","fumarate","Tesmilifene fumarate","CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.OC(=O)\\C=C\\C(O)=O",2.362,3,0,10]
["E0395","Vercirnon","a4","L3900-37","in 10mM DMSO","CCR","GPCR & G Protein","Vercirnon (GSK1605786A, CCX-282, Traficet-EN), an orally bioavailable, selective, and potent antagonist of CCR9, is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9.",444.93,"698394-73-9",{"v":45,"d":"45.00"},101.14,"<1","N/A","http://www.selleckchem.com/products/vercirnon.html","C22H21ClN2O4S","free base","GSK-1605786, CCX-282, Traficet-EN","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(Cl)C=C2C(=O)C3=CC=[N](=O)C=C3",3.791,3,1,6]
["E0404","Zapnometinib (PD0184264)","b4","L3900-37","in 10mM DMSO","MEK","MAPK","Zapnometinib (PD0184264, ATR-002), an major active metabolite of CI-1040, is a novel MEK inhibitor with an IC50 of 5.7 nM.",409.55,"303175-44-2",{"v":82,"d":"82.00"},200.22,"<1","N/A","http://www.selleckchem.com/products/zapnometinib-pd0184264.html","C13H7ClF2INO2","free base","ATR-002","OC(=O)C1=C(NC2=C(Cl)C=C(I)C=C2)C(=C(F)C=C1)F",4.663,1,1,3]
["E0408","JP1302","c4","L3900-37","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","JP-1302(MMV006172), a novel highly selective α2C-adrenoceptor antagonist with Kb of 16 nM at the α2C-adrenoceptor subtype, also produces antidepressant and antipsychotic-like effects.",368.48,"80259-18-3",{"v":74,"d":"74.00"},200.83,"<1","N/A","http://www.selleckchem.com/products/mmv006172.html","C24H24N4","free base","MMV006172","CN1CCN(CC1)C2=CC=C(NC3=C4C=CC=CC4=NC5=CC=CC=C35)C=C2",5.022,1,1,3]
["E0423","(R)-Avanafil","d4","L3900-37","in 10mM DMSO","PDE","Metabolism","R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM.",483.95,"1638497-26-3",{"v":48,"d":"48.00"},99.18,"<1","N/A","http://www.selleckchem.com/products/r-avanafil.html","C23H26ClN7O3","free base","N/A","COC1=C(Cl)C=C(CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)C=C1",2.165,6,3,9]
["E0487","SP-8356","e4","L3900-37","in 10mM DMSO","Others","NF-κB","SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.",300.35,"1454885-45-0",{"v":60,"d":"60.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/sp-8356.html","C18H20O4","free base","N/A","COC1=C(O)C(=CC(=C1)/C=C/C2=CC(=O)C3CC2C3(C)C)O",3.815,2,2,3]
["E0501","Senicapoc (ICA-17043)","f4","L3900-37","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Senicapoc (ICA-17043) is a Gardos channel(Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.",323.34,"289656-45-7",{"v":65,"d":"65.00"},201.03,"<1","N/A","http://www.selleckchem.com/products/senicapoc-ica-17043.html","C20H15F2NO","free base","N/A","NC(=O)C(C1=CC=CC=C1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3",4.221,1,1,4]
["E0502","Metrizoic acid","g4","L3900-37","in 10mM DMSO","Others","Others","Metrizoic acid(Metrizoate) is a diagnostic radiopaque. The mechanism of action of metrizoic acid is as a X-Ray contrast activity.",627.94,"1949-45-7",{"v":100,"d":"100.00"},159.25,"<1","N/A","http://www.selleckchem.com/products/metrizoic-acid.html","C12H11I3N2O4","free base","Metrizoate","CN(C(C)=O)C1=C(I)C(=C(I)C(=C1I)NC(C)=O)C(O)=O",1.641,3,1,3]
["E0527","Norgestimate","h4","L3900-37","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity.",{"v":369.5,"d":"369.50"},"35189-28-7",{"v":74,"d":"74.00"},200.27,"<1","N/A","http://www.selleckchem.com/products/norgestimate.html","C23H31NO3","free base","N/A","CCC12CCC3C(CCC4=C/C(CCC34)=N/O)C1CCC2(OC(C)=O)C#C",5.218,3,0,3]
["E0528","Flecainide","a5","L3900-37","in 10mM DMSO","Others","Neuronal Signaling","Flecainide is a common medication used to help restore and maintain sinus rhythm in patients with atrial fibrillation.",414.34,"54143-55-4",{"v":83,"d":"83.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/flecainide.html","C17H20F6N2O3","free base","N/A","FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC2CCCCN2",3.568,3,2,9]
["E0529","Metipranolol","b5","L3900-37","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Metipranolol (Betamann) is a potent β-adrenergic receptor antagonist, possessing the beta-blocking potencies (pA2) of 8.3, 8.4 at guinea pig atrial β1-adrenoceptor and β2-adrenoceptor of the rat uterus, respectively, also is a potent displacer of 3H-DHA binding, ligand concentration 0.7 nM, possessing a Ki value of 39 ± 24 nM.",{"v":309.4,"d":"309.40"},"22664-55-7",{"v":62,"d":"62.00"},200.39,"<1","N/A","http://www.selleckchem.com/products/metipranolol.html","C17H27NO4","free base","Betamann","CC(C)NCC(O)COC1=CC(=C(OC(C)=O)C(=C1C)C)C",2.858,3,2,8]
["E0530","Prednicarbate","c5","L3900-37","in 10mM DMSO","Others","Endocrinology & Hormones","Prednicarbate (Dermatop) is a medium potency topical corticosteroid used to manage pruritus and inflammation associated with responsive skin conditions.",488.57,"73771-04-7",{"v":98,"d":"98.00"},200.59,"<1","N/A","http://www.selleckchem.com/products/prednicarbate.html","C27H36O8","free base","Dermatop","CCOC(=O)OC1(CCC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C)C(=O)COC(=O)CC",3.677,7,1,9]
["E0617","Lodenafil","d5","L3900-37","in 10mM DMSO","PDE","Metabolism","Lodenafil (Hydroxyhomosildenafil) is a potent phosphodiesterase type 5 (PDE5)  inhibitor for the treatment of erectile dysfunction (ED).",{"v":504.6,"d":"504.60"},"139755-85-4",{"v":100,"d":"100.00"},198.18,"<1","N/A","http://www.selleckchem.com/products/lodenafil.html","C23H32N6O5S","free base","Hydroxyhomosildenafil","CCCC1=N[N](C)C2=C1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S;v6](=O)(=O)N4CCN(CCO)CC4",1.707,6,2,9]
["E0626","AX 20017","e5","L3900-37","in 10mM DMSO","Anti-infection","Microbiology","AX 20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.",264.34,"329221-38-7",{"v":53,"d":"53.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://www.selleckchem.com/products/ax-20017.html","C13H16N2O2S","free base","N/A","NC(=O)C1=C(NC(=O)C2CC2)SC3=C1CCCC3",{"v":1.88,"d":"1.880"},2,2,3]
["E0637","Cedirogant","f5","L3900-37","in 10mM DMSO","ROR","Metabolism","Cedirogant (ABBV-157) is an orally active RORγt inverse agonist, can be used for psoriasis research.",547.78,"2055496-11-0",{"v":100,"d":"100.00"},182.56,"<1","N/A","http://www.selleckchem.com/products/cedirogant.html","C24H20Cl3F3N2O3","free base","ABBV-157","OC(=O)CC1CCN(CC1)C(=O)C2=CC=C(Cl)C(=C2Cl)C[N]3C=CC4=CC(=CC(=C34)Cl)C(F)(F)F",6.609,2,0,6]
["E0646","Ibiglustat succinate","g5","L3900-37","in 10mM DMSO","Glucosylceramide Synthase","Metabolism","Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.",523.58,"1629063-78-0",{"v":100,"d":"100.00"},190.99,{"v":100,"d":"100.00"},190.99,"http://www.selleckchem.com/products/ibiglustat-succinate.html","C20H24FN3O2S.C4H6O5","succinate","Venglustat succinate","CC(C)(NC(=O)OC1CN2CCC1CC2)C3=CSC(=N3)C4=CC=C(F)C=C4.OC(CC(O)=O)C(O)=O",0.421,5,2,8]
["E0704","Esaxerenone (CS-3150)","h5","L3900-37","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Esaxerenone (CS-3150), a selective nonsteroidal mineralocorticoid receptor (MR) antagonist, binds to mineralocorticoid receptor and inhibits (3)H-aldosterone binding to mineralocorticoid receptor with an IC50 value of 9.4 nM. Esaxerenone (CS-3150) also has the property of increasing the likelihood of albuminuria returning to normal levels and reducing progression of albuminuria to higher levels.",466.48,"1632006-28-0",{"v":93,"d":"93.00"},199.37,{"v":-1,"d":"-1.00"},-2.14,"http://www.selleckchem.com/products/esaxerenone.html","C22H21F3N2O4S","free base","N/A","CC1=C([N](CCO)C=C1C(=O)NC2=CC=C(C=C2)[S](C)(=O)=O)C3=CC=CC=C3C(F)(F)F",4.139,3,2,7]
["E0706","Gemifloxacin mesylate","a6","L3900-37","in 10mM DMSO","Antibiotics","Microbiology","Gemifloxacin mesylate (SB265805 mesylate; LB20304 mesylate) is a novel fluoronaphthyridone with a broad spectrum of antimicrobial activity and enhances activity against gram-positive aerobes.",485.49,"210353-53-0",{"v":97,"d":"97.00"},{"v":199.8,"d":"199.80"},{"v":97,"d":"97.00"},{"v":199.8,"d":"199.80"},"http://www.selleckchem.com/products/gemifloxacin-mesylate.html","C18H20FN5O4.CH4O3S","Mesylate","SB265805 mesylate; LB20304 mesylate","CO\\N=C\\1CN(CC1CN)C2=C(F)C=C3C(=O)C(=CN(C4CC4)C3=N2)C(O)=O.C[S](O)(=O)=O",-1.513,5,1,5]
["E0707","Nomegestrol Acetate","b6","L3900-37","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Nomegestrol Acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.",370.48,"58652-20-3",{"v":74,"d":"74.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/nomegestrol-acetate.html","C23H30O4","free base","N/A","CC(=O)OC1(CCC2C3C=C(C)C4=CC(=O)CCC4C3CCC12C)C(C)=O",3.299,4,0,3]
["E0758","Silydianin","c6","L3900-37","in 10mM DMSO","phosphatase","Metabolism","Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities.",482.44,"29782-68-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/silydianin.html","C25H22O10","free base","N/A","COC1=C(O)C=CC(=C1)C2C3COC4(O)C3C(=CC2C4=O)C5OC6=CC(=CC(=C6C(=O)C5O)O)O",1.059,5,4,3]
["E0777","Z944","d6","L3900-37","in 10mM DMSO","Calcium Channel","Neuronal Signaling","Z944 is a highly selective antagonist for T-type calcium channel with IC50s of 50, 160, 110 nM for hCaV3.1, hCaV3.2, and hCaV3.3.",383.89,"1199236-64-0",{"v":19,"d":"19.00"},49.49,"<1","N/A","http://www.selleckchem.com/products/z944.html","C19H27ClFN3O2","free base","N/A","CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)C2=CC(=CC(=C2)Cl)F",2.587,2,2,6]
["E0789","SC-58125","e6","L3900-37","in 10mM DMSO","COX","Immunology & Inflammation","SC-58125 is a potent and selective inhibitor of human cyclooxygenase 2 (hCOX-2) and triple mutant of hCOX-2, with an IC50 of 0.04 μM and 1 µM, respectively.",384.35,"162054-19-5",{"v":77,"d":"77.00"},200.34,"<1","N/A","http://www.selleckchem.com/products/sc-58125.html","C17H12F4N2O2S","free base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(F)C=C3)C(F)(F)F",4.968,3,0,4]
["E0794","MID-1","f6","L3900-37","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction, which can disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.",{"v":293.3,"d":"293.30"},"312608-54-1",{"v":30,"d":"30.00"},102.28,"<1","N/A","http://www.selleckchem.com/products/mid-1.html","C12H11N3O4S","free base","N/A","CCOC1=CC=C(C=C1)C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.963,3,1,5]
["E0809","Timapiprant Sodium","g6","L3900-37","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Timapiprant sodium (OC000459 sodium), a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist, potently displaces [3H]PGD2 from human recombinant DP2, rat recombinant DP2, and human native DP2 with Ki values of 13, 3 and 4 nM, respectively.",371.36,"950688-14-9",{"v":74,"d":"74.00"},199.27,"<1","N/A","http://www.selleckchem.com/products/timapiprant-sodium.html","C21H17FN2O2.Na","Sodium salt","OC000459 sodium","[NaH].CC1=C(CC2=NC3=C(C=CC=C3)C=C2)C4=CC(=CC=C4[N]1CC(O)=O)F",4.329,2,0,4]
["E0812","CXD101","h6","L3900-37","in 10mM DMSO","HDAC","NF-κB","CXD101 (HDAC-IN-4) is a potent, selective and orally active class I histone deacetylase (HDAC) inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively.",403.52,"934828-12-3",{"v":81,"d":"81.00"},200.73,"<1","N/A","http://www.selleckchem.com/products/cxd101.html","C24H29N5O","free base","HDAC-IN-4","C[N]1C=C(CN2CCC(CC2)C3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N)C(=N1)C",3.075,2,2,5]
["E0814","Masitinib mesylate","a7","L3900-37","in 10mM DMSO","c-Kit,FAK,FGFR,PDGFR,Src","Protein Tyrosine Kinase","Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit with IC50 of 200 nM for human recombinant c-Kit, also inhibits PDGFRα/β with IC50s of 540/800 nM, Lyn with IC50 of 510 nM for LynB, and, to a lesser extent, FGFR3 and FAK.",594.75,"1048007-93-7",{"v":100,"d":"100.00"},168.14,{"v":100,"d":"100.00"},168.14,"https://www.selleckchem.com/products/masitinib-mesylate.html","C28H30N6OS.CH4O3S","Mesylate","AB-1010 mesylate","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC(=CS4)C5=CN=CC=C5.C[S](O)(=O)=O",4.795,3,2,7]
["E0815","Rilpivirine Hydrochloride","b7","L3900-37","in 10mM DMSO","Reverse Transcriptase","Microbiology","Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.",402.88,"700361-47-3",{"v":81,"d":"81.00"},201.05,"<1","N/A","http://www.selleckchem.com/products/rilpivirine-hydrochloride.html","C22H18N6.ClH","hydrochloride","TMC278","Cl.CC1=C(NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C(=CC(=C1)\\C=C\\C#N)C",5.791,2,2,5]
["E0816","Oritavancin Diphosphate","c7","L3900-37","in 10mM DMSO","Bacterial","Microbiology","Oritavancin Diphosphate is an orally active glycopeptide antibiotic which is active against Gram-positive bacteria and also has antibacterial activity against multidrug-resistant Streptococcus pneumoniae.",1989.09,"192564-14-0",{"v":100,"d":"100.00"},50.27,{"v":50,"d":"50.00"},25.14,"http://www.selleckchem.com/products/oritavancin-diphosphate.html","C86H97Cl3N10O26.2H3O4P","Diphosphate","N/A","CNC(CC(C)C)C(=O)NC1C(O)C2=CC(=C(OC3=C(OC4OC(CO)C(O)C(O)C4OC5CC(C)(NCC6=CC=C(C=C6)C7=CC=C(Cl)C=C7)C(O)C(C)O5)C8=CC(=C3)C(NC(=O)C(CC(N)=O)NC1=O)C(=O)NC9C(=O)NC(C(OC%10CC(C)(N)C(O)C(C)O%10)C%11=CC(=C(O8)C=C%11)Cl)C(=O)NC(C(O)=O)C%12=C(C(=CC(=C%12)O)O)C%13=C(O)C=CC9=C%13)C=C2)Cl.O[P](O)(O)=O.O[P](O)(O)=O",0.667,16,19,19]
["E0822","AST-1306","d7","L3900-37","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AST-1306 (Allitinib) is an orally active and irreversible EGFR, ErbB2 and   inhibitor with IC50s of 0.5, 3 and 0.8 nM, respectively.",448.88,"897383-62-9",{"v":90,"d":"90.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://www.selleckchem.com/products/ast-1306.html","C24H18ClFN4O2","free base","Allitinib","FC1=CC=CC(=C1)COC2=C(Cl)C=C(NC3=NC=NC4=C3C=C(NC(=O)C=C)C=C4)C=C2",5.732,4,2,7]
["E0826","Levamlodipine Besylate","e7","L3900-37","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levamlodipine Besylate is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.",448.88,"150566-71-5",{"v":100,"d":"100.00"},222.78,{"v":2,"d":"2.00"},4.46,"http://www.selleckchem.com/products/levamlodipine-besylate.html","C20H25ClN2O5.C6H6O3S","Besylate","N/A","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C.O[S](=O)(=O)C3=CC=CC=C3",3.473,5,2,11]
["E0828","Mitonafide","f7","L3900-37","in 10mM DMSO","Bacterial","Microbiology","Mitonafide inhibits the activity of Mycobacterium tuberculosis NAD+ dependent DNA ligase A at concentrations of 50 µM.",313.31,"54824-17-8",{"v":32,"d":"32.00"},102.14,"<1","N/A","http://www.selleckchem.com/products/mitonafide.html","C16H15N3O4","free base","N/A","CN(C)CCN1C(=O)C2=CC=CC3=C2C(=CC(=C3)[N;v5](=O)=O)C1=O",1.803,2,0,4]
["E0937","Segesterone acetate","g7","L3900-37","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Segesterone acetate (Nestoron, ST-1435) is a synthetic progestin that binds to the progesterone receptor with EC50 of 50.3 nM.",370.48,"7759-35-5",{"v":74,"d":"74.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/segesterone.html","C23H30O4","free base","Nestoron, ST-1435","CC(=O)OC1(C(C)=O)C(=C)CC2C3CCC4=CC(=O)CCC4C3CCC12C",3.488,4,0,3]
["E0948","Rebamipide mofetil","h7","L3900-37","in 10mM DMSO","Procollagen C Proteinase","Immunology & Inflammation","Rebamipide mofetil is an orally active prodrug of Rebamipide (OPC12759). Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner.",483.94,"1527495-76-6",{"v":97,"d":"97.00"},200.44,"<1","N/A","http://www.selleckchem.com/products/rebamipide-mofetil.html","C25H26ClN3O5","free base","N/A","ClC1=CC=C(C=C1)C(=O)NC(CC2=CC(=O)NC3=CC=CC=C23)C(=O)OCCN4CCOCC4",2.658,5,2,9]
["E0960","RO5186582","a8","L3900-37","in 10mM DMSO","GABA Receptor","Transmembrane Transporters","RO5186582 (Basmisanil, RG1662) is a highly selective GABAAα5 negative allosteric modulator.",445.47,"1159600-41-5",{"v":89,"d":"89.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/ro5186582.html","C21H20FN3O5S","free base","Basmisanil, RG1662","CC1=C(COC2=CC=C(C=N2)C(=O)N3CC[S;v6](=O)(=O)CC3)C(=NO1)C4=CC=C(F)C=C4",2.368,7,0,5]
["E1014","Upamostat (WX-671)","b8","L3900-37","in 10mM DMSO","Serine Protease","Proteases","Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.",629.81,"590368-25-5",{"v":100,"d":"100.00"},158.78,"<1","N/A","http://www.selleckchem.com/products/upamostat-wx-671.html","C32H47N5O6S","free base","WX-671","CCOC(=O)N1CCN(CC1)C(=O)C(CC2=CC(=CC=C2)C(=N)NO)N[S](=O)(=O)C3=C(C=C(C=C3C(C)C)C(C)C)C(C)C",4.907,5,2,13]
["E1016","Aficamten (CK-274)","c8","L3900-37","in 10mM DMSO","Cardiac Myosin","Cytoskeletal Signaling","Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractility in vitro and in vivo with an IC50 of 1.4 μM.",337.38,"2364554-48-1",{"v":67,"d":"67.00"},198.59,"<1","N/A","http://www.selleckchem.com/products/aficamten-ck-274.html","C18H19N5O2","free base","CK 3773274","CCC1=NC(=NO1)C2=CC=C3C(CCC3=C2)NC(=O)C4=C[N](C)N=C4",2.148,5,1,4]
["E1095","ODM-207","d8","L3900-37","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.",375.42,"1801503-93-4",{"v":38,"d":"38.00"},101.22,"<1","N/A","http://www.selleckchem.com/products/odm-207.html","C22H21N3O3","free base","N/A","COC1=C(C=C2C=C(C)C(=O)N(CC3=CC=CC=N3)C2=C1)C4=C(C)ON=C4C",2.937,5,0,4]
["E1107","CTB","e8","L3900-37","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","CTB is a p300 activator and the lowest docked energy for CTB and p300 is 7.72 kcal/mol.",343.73,"451491-47-7",{"v":69,"d":"69.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/ctb.html","C16H13ClF3NO2","free base","N/A","CCOC1=CC=CC=C1C(=O)NC2=CC=C(Cl)C(=C2)C(F)(F)F",4.553,2,1,5]
["E1126","AFN-1252","f8","L3900-37","in 10mM DMSO","Anti-infection","Microbiology","AFN-1252 (Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibits all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.",375.42,"620175-39-5",{"v":9,"d":"9.00"},23.97,"<1","N/A","http://www.selleckchem.com/products/afn-1252.html","C22H21N3O3","free base","Debio 1452","CN(CC1=C(C)C2=C(O1)C=CC=C2)C(=O)/C=C/C3=CC4=C(NC(=O)CC4)N=C3",2.997,4,1,4]
["E1152","AGX51","g8","L3900-37","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","AGX51, a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader, inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability, also inhibits pathologic ocular neovascularization.",431.52,"330834-54-3","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/agx51.html","C27H29NO4","free base","N/A","CCC(=O)N(CCC(C1=CC2=C(OCO2)C=C1)C3=C(OC)C=CC=C3)CC4=CC=CC=C4",5.226,4,0,9]
["E1166","tetrathiomolybdate","h8","L3900-37","in 10mM DMSO","ATPase","Transmembrane Transporters","Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson’s disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.",{"v":224.2,"d":"224.20"},"16330-92-0",{"v":45,"d":"45.00"},200.71,"<1","N/A","http://www.selleckchem.com/products/tetrathiomolybdate.html","MoS4","free base","N/A","S=[Mo--;v8](=S)(=S)=S",3.503,0,0,0]
["E1178","FHD-286","a9","L3900-37","in 10mM DMSO","ATPase","Transmembrane Transporters","FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.",562.66,"2671128-05-3",{"v":100,"d":"100.00"},177.73,"<1","N/A","http://www.selleckchem.com/products/fhd-286.html","C24H30N6O6S2","free base","N/A","COCC(NC(=O)C1=C[N](C=C1)[S;v6](C)(=O)=O)C(=O)NC2=NC(=CS2)C3=CC=CC(=N3)N4CC(C)OC(C)C4",1.919,8,2,9]
["E2037","Kisspeptin-10 (human)","b9","L3900-37","in 10mM DMSO","GPR","GPCR & G Protein","Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis, acts as a tumor metastasis suppressor via its receptor GPR54, inducing osteoblast differentiation via NFATc4-mediated BMP2 expression.",1302.44,"374675-21-5",{"v":100,"d":"100.00"},76.78,{"v":25,"d":"25.00"},19.19,"http://www.selleckchem.com/products/kisspeptin-10.html","C63H83N17O14","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CC(N)=O)NC(=O)C(N)CC4=CC=C(O)C=C4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC5=CC=CC=C5)C(N)=O",-2.442,12,18,39]
["E2147","AZD-9574","c9","L3900-37","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AZD-9574 is a novel PARP inhibitor which combines PARP1 selectivity, trapping and high CNS penetration in a single molecule.",428.44,"2756333-39-6",{"v":86,"d":"86.00"},200.73,"<1","N/A","http://www.selleckchem.com/products/azd-9574.html","C21H22F2N6O2","free base","N/A","CNC(=O)C1=NC(=C(C=C1)N2CCN(CC2)CC3=CC=C4N=C(C)C(=O)NC4=C3F)F",1.815,4,2,4]
["E2203","DMU-212","d9","L3900-37","in 10mM DMSO","ERK","MAPK","DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein.",300.35,"134029-62-2",{"v":30,"d":"30.00"},99.88,"<1","N/A","http://www.selleckchem.com/products/dmu-212.html","C18H20O4","free base","N/A","COC1=CC=C(C=C1)/C=C/C2=CC(=C(OC)C(=C2)OC)OC",{"v":3.75,"d":"3.750"},4,0,6]
["E2355","Dotinurad","e9","L3900-37","in 10mM DMSO","OAT","Transmembrane Transporters","Dotinurad (FYU-981), a selective urate reabsorption inhibitor (SURI), potently inhibits urate transporter 1 (URAT1) with IC50 of 37.2 nM.",{"v":358.2,"d":"358.20"},"1285572-51-1",{"v":72,"d":"72.00"},201.01,"<1","N/A","http://www.selleckchem.com/products/dotinurad.html","C14H9Cl2NO4S","free base","FYU-981","OC1=C(Cl)C=C(C=C1Cl)C(=O)N2C[S;v6](=O)(=O)C3=CC=CC=C23",3.234,3,1,1]
["E2356","Tandospirone","f9","L3900-37","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Tandospirone (SM-3997), a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM, has anxiolytic and antidepressant activities.",383.49,"87760-53-0",{"v":26,"d":"26.00"},{"v":67.8,"d":"67.80"},"<1","N/A","http://www.selleckchem.com/products/tandospirone.html","C21H29N5O2","free base","SM-3997","O=C1C2C3CCC(C3)C2C(=O)N1CCCCN4CCN(CC4)C5=NC=CC=N5",1.707,4,0,6]
["E2358","Azosemide","g9","L3900-37","in 10mM DMSO","NKCC","Transmembrane Transporters","Azosemide is a potent Na+–K+–2Cl− cotransporter NKCC1 inhibitor with IC50s of 0.246 µM for hNKCC1A and 0.197 µM for NKCC1B, respectively.",370.84,"27589-33-9",{"v":74,"d":"74.00"},199.55,"<1","N/A","http://www.selleckchem.com/products/azosemide.html","C12H11ClN6O2S2","free base","N/A","N[S](=O)(=O)C1=CC(=C(NCC2=CC=CS2)C=C1Cl)C3=N[NH]N=N3",1.801,5,3,5]
["E2385","SAR407899 hydrochloride","h9","L3900-37","in 10mM DMSO","Rho","Cell Cycle","SAR407899 hydrochloride is a selective, potent and ATP-competitive Rho kinase (ROCK) inhibitor, with an IC50 of 135 nM for ROCK-2, and Ki values of 36 and 41 nM for human and rat ROCK-2, respectively.",280.75,"923262-96-8",{"v":28,"d":"28.00"},99.73,{"v":56,"d":"56.00"},199.47,"http://www.selleckchem.com/products/sar407899-hydrochloride.html","C14H16N2O2.ClH","hydrochloride","N/A","Cl.O=C1NC=CC2=C1C=CC(=C2)OC3CCNCC3",0.667,2,2,2]
["E2391","α-Linolenic acid","a10","L3900-37","in 10mM DMSO","Akt,PI3K","PI3K/Akt/mTOR","α-Linolenic acid, an essential fatty acid isolated from seed oils, affects the process of thrombotic through the modulation of PI3K/Akt signaling, and possesses the anti-arrhythmic properties.",278.43,"463-40-1","The physical form of the compound is liquid, which can be dissolved in any proportion","The physical form of the compound is liquid, which can be dissolved in any proportion","N/A","N/A","http://www.selleckchem.com/products/alpha-Linolenic-acid.html","C18H30O2","free base","N/A","CC\\C=C/C/C=C\\C\\C=C/CCCCCCCC(O)=O",5.971,1,0,13]
["E2393","JNJ-10198409","b10","L3900-37","in 10mM DMSO","PDGFR","Protein Tyrosine Kinase","JNJ-10198409, a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor with IC50 of 2 nM, is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent, has good activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.",325.34,"627518-40-5",{"v":65,"d":"65.00"},199.79,"<1","N/A","http://www.selleckchem.com/products/jnj-10198409.html","C18H16FN3O2","free base","N/A","COC1=CC2=C(C=C1OC)C3=C(C2)C(=N[NH]3)NC4=CC=CC(=C4)F",{"v":4.49,"d":"4.490"},3,2,4]
["E2402","T-1101 tosylate","c10","L3900-37","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity.",665.81,"2250404-95-4",{"v":100,"d":"100.00"},150.19,"<1","N/A","http://www.selleckchem.com/products/t-1101-tosylate.html","C24H23N5O3S2.C7H8O3S","tosylate","TAI-95 tosylate","COCCOC1=CN=C(SC2=CC(=C(C(=C2)C)C3=CSC(=N3)NC(=O)C4=CC=NC=C4)C)C=N1.CC5=CC=C(C=C5)[S](O)(=O)=O",6.511,7,1,10]
["E2516","Doxorubicin","d10","L3900-37","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM.",543.52,"23214-92-8",{"v":100,"d":"100.00"},183.99,{"v":50,"d":"50.00"},91.99,"http://www.selleckchem.com/products/doxorubicin.html","C27H29NO11","free base","Adriamycin,Hydroxydaunorubicin","COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",-0.044,6,5,5]
["E2642","CGP60474","e10","L3900-37","in 10mM DMSO","CDK","Cell Cycle","CGP60474, a highly potent anti-endotoxemic  agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively).",355.82,"164658-13-3",{"v":71,"d":"71.00"},199.54,"<1","N/A","http://www.selleckchem.com/products/cgp60474.html","C18H18ClN5O","free base","N/A","OCCCNC1=NC=CC(=C1)C2=NC(=NC=C2)NC3=CC=CC(=C3)Cl",3.453,3,3,7]
["E2664","Cridanimod","f10","L3900-37","in 10mM DMSO","STING","Immunology & Inflammation","Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).",253.25,"38609-97-1",{"v":51,"d":"51.00"},201.38,"<1","N/A","http://www.selleckchem.com/products/cridanimod.html","C15H11NO3","free base","N/A","OC(=O)CN1C2=CC=CC=C2C(=O)C3=C1C=CC=C3",2.641,2,0,2]
["E2683","Ursodeoxycholic acid sodium","g10","L3900-37","in 10mM DMSO","Others","Others","Ursodeoxycholic acid sodium is a sodium salt of a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases.",414.55,"2898-95-5",{"v":83,"d":"83.00"},200.22,{"v":83,"d":"83.00"},200.22,"http://www.selleckchem.com/products/ursodeoxycholic-acid-sodium.html","C24H40O4.Na","Sodium salt","N/A","[Na+].CC(CCC([O-])=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",{"v":2.54,"d":"2.540"},0,2,4]
["E2838","M7583","h10","L3900-37","in 10mM DMSO","BTK","Angiogenesis","M7583 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively.",447.51,"1415823-49-2",{"v":90,"d":"90.00"},201.11,"<1","N/A","http://www.selleckchem.com/products/tl-895.html","C25H26FN5O2","free base","N/A","NC1=C(C(=NC=N1)NCC2(F)CCN(CC2)C(=O)C=C)C3=CC=C(OC4=CC=CC=C4)C=C3",3.594,4,2,7]
["P1008","Carbetocin Acetate","a11","L3900-37","in 10mM DMSO","Oxytocin receptor","Endocrinology & Hormones","Carbetocin Acetate is a long-acting oxytocin-analogue and a potent agonist of the oxytocin receptor (OXTR), with improved in vivo stability over oxytocin.",988.16,"37025-55-1",{"v":100,"d":"100.00"},{"v":101.2,"d":"101.20"},{"v":100,"d":"100.00"},{"v":101.2,"d":"101.20"},"http://www.selleckchem.com/peptide/carbetocin-acetate.html","C45H69N11O12S","Acetate","N/A","CCC(C)C1NC(=O)C(CC2=CC=C(OC)C=C2)NC(=O)CCCSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(N)=O.CC(O)=O",-1.699,13,10,18]
["P1095","BAM (8-22)","b11","L3900-37","in 10mM DMSO","Others","GPCR & G Protein","BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.",1971.21,"412961-36-5",{"v":100,"d":"100.00"},50.73,{"v":100,"d":"100.00"},50.73,"http://www.selleckchem.com/products/bam--8-22-.html","C91H127N25O23S","Diacetate","N/A","CSCCC(NC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(CCC(O)=O)NC(=O)C5CCCN5C(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(N)C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC7=CC=C(O)C=C7)C(=O)NCC(O)=O",-8.438,18,24,62]
["P1108","Bremelanotide Acetate","c11","L3900-37","in 10mM DMSO","Melanocortin Receptor","Endocrinology & Hormones","Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.",1085.22,"1607799-13-2",{"v":100,"d":"100.00"},92.15,{"v":100,"d":"100.00"},92.15,"http://www.selleckchem.com/products/bremelanotide-acetate.html","C50H68N14O10.C2H4O2","Acetate","PT141 Acetate","CCCCC(NC(C)=O)C(=O)NC1CC(=O)NCCCCC(NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=C[NH]5)NC1=O)C(O)=O.CC(O)=O",{"v":0.28,"d":"0.280"},12,12,17]
["P1110","Etelcalcetide HCl","d11","L3900-37","in 10mM DMSO","CaSR","GPCR & G Protein","Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.",1084.71,"1334237-71-6",{"v":100,"d":"100.00"},92.19,{"v":100,"d":"100.00"},92.19,"http://www.selleckchem.com/products/etelcalcetide-hcl.html","C38H74ClN21O10S2","hydrochloride","AMG 416","Cl.CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(S)C(N)(S)C(O)=O)NC(C)=O)C(=O)NC(CCCN=C(N)N)C(N)=O",-9.149,13,17,34]
["P1114","Dasiglucagon","e11","L3900-37","in 10mM DMSO","Others","Metabolism","Dasiglucagon, a stable peptide analog of human glucagon, is a fast and effective treatment option for severe hypoglycemia.",3381.62,"1544300-84-6",{"v":100,"d":"100.00"},29.57,{"v":100,"d":"100.00"},29.57,"http://www.selleckchem.com/products/dasiglucagon.html","C152H222N38O50","free base","N/A","CC(C)CC(NC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(CC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC5=CC=C(O)C=C5)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC6=CC=CC=C6)NC(=O)C(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CO)NC(=O)C(N)CC7=CN=C[NH]7)C(C)O)C(C)O)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(C(C)O)C(O)=O",-19.686,36,45,110]
["P1116","Epitalon","f11","L3900-37","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Epitalon is an anti-aging agent and a telomerase activator, with an inhibitory effect of the on the development of spontaneous tumors in mice, as well as geroprotective actions and intranasal administration increases neuronal activity, also can be used for cancer, old age and Retinitis Pigmentosa.",390.35,"307297-39-8",{"v":78,"d":"78.00"},199.82,{"v":78,"d":"78.00"},199.82,"http://www.selleckchem.com/products/epitalon.html","C14H22N4O9","free base","Epithalon","CC(N)C(=O)NC(CCC(O)=O)C(=O)NC(CC(O)=O)C(=O)NCC(O)=O",{"v":-5.93,"d":"-5.930"},6,4,12]
["P1152","Oglufanide","g11","L3900-37","in 10mM DMSO","Antiviral,Bacterial,VEGFR","Protein Tyrosine Kinase","Oglufanide (H-Glu-Trp-OH, L-Glutamyl-L-tryptophan), a dipeptide immunomodulator isolated from calf thymus, inhibits vascular endothelial growth factor (VEGF), also stimulates the immune response to hepatitic C virus (HCV) and intracellular bacterial infections.",333.34,"38101-59-6",{"v":34,"d":"34.00"},{"v":102,"d":"102.00"},"<1","N/A","http://www.selleckchem.com/products/qglufanide.html","C16H19N3O5","free base","H-Glu-Trp-OH, L-Glutamyl-L-tryptophan","NC(CCC(O)=O)C(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(O)=O",-2.066,3,3,8]
["P1161","Angstrom6","h11","L3900-37","in 10mM DMSO","CD markers","Immunology & Inflammation","Angstrom6 (A6 Peptide) is a capped, eight l-amino acid peptide (Ac-KPSSPPEE-NH2) derived from the biologically active connecting peptide domain of the serine protease, human urokinase plasminogen activator (uPA), which can binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.",910.97,"220334-14-5",{"v":100,"d":"100.00"},109.77,{"v":100,"d":"100.00"},109.77,"http://www.selleckchem.com/products/angstrom6.html","C39H62N10O15","free base","A6 Peptide","CC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CO)C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(N)=O",-8.457,11,9,25]
["P1216","Box5","a2","L3900-38","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.",666.76,"881188-48-3",{"v":100,"d":"100.00"},149.98,{"v":2,"d":"2.00"},{"v":3,"d":"3.00"},"http://www.selleckchem.com/products/box5.html","C25H42N6O11S2","free base","N/A","CSCCC(N)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CS)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(O)=O",{"v":-5.2,"d":"-5.200"},8,6,22]
["P1218","Disitertide(P144)","b2","L3900-38","in 10mM DMSO","PI3K,TGF-beta/Smad","TGF-beta/Smad","Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor, is also a PI3K inhibitor and an apoptosis inducer.",1580.83,"272105-42-7",{"v":25,"d":"25.00"},15.81,"<1","N/A","http://www.selleckchem.com/products/disitertide.html","C68H109N17O22S2","free base","N/A","CCC(C)C(NC(=O)C(NC(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(N)C(C)O)C(C)CC)C(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(=O)NC(C)C(=O)NC(CCSC)C(=O)NC(CCSC)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(O)=O",-7.833,17,20,51]
["P1220","tat-nr2b9c","c2","L3900-38","in 10mM DMSO","Others","Neuronal Signaling","Tat-NR2B9c (Tat-NR2Bct, NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively, and disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively, also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.",2518.88,"500992-11-0",{"v":100,"d":"100.00"},{"v":39.7,"d":"39.70"},{"v":100,"d":"100.00"},{"v":39.7,"d":"39.70"},"http://www.selleckchem.com/products/tat-nr2b9c.html","C105H188N42O30","free base","Nerinetide, NA-1","CCC(C)C(NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(N)CC1=CC=C(O)C=C1)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(CC(O)=O)C(=O)NC(C(C)C)C(O)=O",{"v":-21.34,"d":"-21.340"},23,40,99]
["S1469","Calcifediol","d2","L3900-38","in 10mM DMSO","Vitamin","Metabolism","Calcifediol (Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).",400.64,"19356-17-3",{"v":80,"d":"80.00"},199.68,"<1","N/A","http://www.selleckchem.com/products/Calcifediol.html","C27H44O2","free base","Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol","CC(CCCC(C)(C)O)C1CCC2/C(CCCC12C)=C/C=C3/CC(O)CCC3=C",6.404,0,1,6]
["S2841","Bemcentinib (R428)","e2","L3900-38","in 10mM DMSO","Axl","Protein Tyrosine Kinase","Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).",506.64,"1037624-75-1",{"v":6,"d":"6.00"},11.84,"<1","N/A","http://www.selleckchem.com/products/r428.html","C30H34N8","free base","BGB324","NC1=NC(=N[N]1C2=NN=C3C(=C2)CCCC4=CC=CC=C34)NC5=CC=C6CCC(CCC6=C5)N7CCCC7",7.035,4,2,4]
["S6918","Oleandrin (PBI-05204)","f2","L3900-38","in 10mM DMSO","ATPase","Transmembrane Transporters","Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) is an inhibitor of Na+/K+-ATPase with IC50 of 0.62 μM. Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro.",576.72,"465-16-7",{"v":100,"d":"100.00"},173.39,"<1","N/A","http://www.selleckchem.com/products/oleandrin-pbi-05204.html","C32H48O9","free base","Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol","COC1CC(OC(C)C1O)OC2CCC3(C)C(CCC4C3CCC5(C)C(C(CC45O)OC(C)=O)C6=CC(=O)OC6)C2",{"v":2.78,"d":"2.780"},7,1,6]
["S7048","Talazoparib (BMN 673)","g2","L3900-38","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Talazoparib (BMN 673, LT-673) is a novel PARP inhibitor with IC50 of 0.57 nM for PARP1 in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.",380.35,"1207456-01-6",{"v":38,"d":"38.00"},99.91,"<1","N/A","http://www.selleckchem.com/products/bmn-673.html","C19H14F2N6O","free base","LT-673","C[N]1N=CN=C1C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(F)C=C5",2.467,4,2,2]
["S7062","Pinometostat (EPZ5676)","h2","L3900-38","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.",562.71,"1380288-87-8",{"v":100,"d":"100.00"},177.71,"<1","N/A","http://www.selleckchem.com/products/epz-5676.html","C30H42N8O3","free base","N/A","CC(C)N(CC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N)C4CC(CCC5=NC6=CC=C(C=C6[NH]5)C(C)(C)C)C4",3.567,5,4,9]
["S7108","Encorafenib (LGX818)","a3","L3900-38","in 10mM DMSO","Raf","MAPK","Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3.",540.01,"1269440-17-6",{"v":100,"d":"100.00"},185.18,"<1","N/A","http://www.selleckchem.com/products/lgx818.html","C22 H27 Cl F N7 O4 S","free base","N/A","COC(=O)NC(C)CNC1=NC=CC(=N1)C2=C[N](N=C2C3=C(F)C(=CC(=C3)Cl)N[S;v6](C)(=O)=O)C(C)C",3.645,7,3,10]
["S7817","MI-503","b3","L3900-38","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.",564.63,"1857417-13-0",{"v":100,"d":"100.00"},177.11,"<1","N/A","http://www.selleckchem.com/products/mi-503.html","C28H27F3N8S","free base","N/A","CC1=C2C=C(C#N)[N](CC3=C[NH]N=C3)C2=CC=C1CN4CCC(CC4)NC5=C6C=C(CC(F)(F)F)SC6=NC=N5",5.606,3,2,8]
["S8162","Upadacitinib (ABT-494)","c3","L3900-38","in 10mM DMSO","JAK","JAK/STAT","Upadacitinib (ABT-494) is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM),  with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1.",380.37,"1310726-60-3",{"v":76,"d":"76.00"},199.81,"<1","N/A","http://www.selleckchem.com/products/upadacitinib.html","C17H19F3N6O","free base","N/A","CCC1CN(CC1C2=CN=C3C=NC4=C(C=C[NH]4)[N]23)C(=O)NCC(F)(F)F",1.967,3,2,4]
["S8297","ARV-825","d3","L3900-38","in 10mM DMSO","Epigenetic Reader Domain,PROTAC","Epigenetics","ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC.",923.43,"1818885-28-7",{"v":100,"d":"100.00"},108.29,"<1","N/A","http://www.selleckchem.com/products/arv-825.html","C46H47ClN8O9S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(OCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C7CCC(=O)NC7=O)C6=O)C=C4)N=C2C8=CC=C(Cl)C=C8)C",4.266,12,3,19]
["S8344","AZD-5153 6-hydroxy-2-naphthoic acid","e3","L3900-38","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.",667.75,"1869912-40-2",{"v":100,"d":"100.00"},149.76,"<1","N/A","http://www.selleckchem.com/products/azd5153-6-hydroxy-2-naphthoic-acid.html","C25H33N7O3.C11H8O3","free base","AZD-5153 HNT salt","COC1=NN=C2C=CC(=N[N]12)N3CCC(CC3)C4=CC=C(OCCN5CCN(C)C(=O)C5C)C=C4.OC(=O)C6=CC=C7C=C(O)C=CC7=C6",2.347,7,1,8]
["S8381","BMS-986142","f3","L3900-38","in 10mM DMSO","BTK","Protein Tyrosine Kinase","BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK with an IC50 of 0.5 nM. In a panel of 384 kinases, only five kinases were inhibited by BMS-986142 with less than 100-fold selectivity for BTK (TEC, ITK, BLK, TXK and BMX).",{"v":572.6,"d":"572.60"},"1643368-58-4",{"v":100,"d":"100.00"},174.64,"<1","N/A","http://www.selleckchem.com/products/bms-986142.html","C32H30F2N4O4","free base","N/A","CN1C(=O)N(C(=O)C2=CC=CC(=C12)F)C3=CC=CC(=C3C)C4=C5C6=C(CC(CC6)C(C)(C)O)[NH]C5=C(C=C4F)C(N)=O",5.323,3,2,4]
["S8421","Fenebrutinib (GDC-0853)","g3","L3900-38","in 10mM DMSO","BTK","Protein Tyrosine Kinase","Fenebrutinib (GDC-0853) is a potent, selective, and non-covalent bruton's tyrosine kinase (BTK) inhibitor with an Ki value of 0.91 nM for Btk with >100-fold selectivity over 3 off-targets (Bmx :153-fold, Fgr: 168-fold, Src:131-fold).",{"v":664.8,"d":"664.80"},"1434048-34-6",{"v":8,"d":"8.00"},12.03,"<1","N/A","http://www.selleckchem.com/products/fenebrutinib-gdc-0853.html","C37H44N8O4","free base","N/A","CC1CN(CCN1C2=CC=C(NC3=CC(=CN(C)C3=O)C4=CC=NC(=C4CO)N5CC[N]6C7=C(CC(C)(C)C7)C=C6C5=O)N=C2)C8COC8",2.621,5,2,7]
["S8553","Avapritinib (BLU-285)","h3","L3900-38","in 10mM DMSO","c-Kit,PDGFR","Protein Tyrosine Kinase","Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).",498.56,"1703793-34-3",{"v":66,"d":"66.00"},132.38,"<1","N/A","http://www.selleckchem.com/products/blu-285.html","C26H27FN10","free base","N/A","C[N]1C=C(C=N1)C2=C[N]3N=CN=C(N4CCN(CC4)C5=NC=C(C=N5)C(C)(N)C6=CC=C(F)C=C6)C3=C2",2.799,5,1,5]
["S8587","Withaferin A","a4","L3900-38","in 10mM DMSO","NF-κB","NF-κB","Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.",{"v":470.6,"d":"470.60"},"5119-48-2",{"v":94,"d":"94.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/withaferin-a.html","C28H38O6","free base","WA, WFA","CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(=O)C6(C)C4CCC23C",3.388,4,2,3]
["S8719","AZD4573","b4","L3900-38","in 10mM DMSO","CDK","Cell Cycle","AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.",429.94,"2057509-72-3",{"v":86,"d":"86.00"},200.03,"<1","N/A","http://www.selleckchem.com/products/azd4573.html","C22H28ClN5O2","free base","N/A","CC(=O)NC1CCCC(C1)C(=O)NC2=CC(=C(Cl)C=N2)C3=C4CC(C)(C)C[N]4N=C3",2.786,4,2,4]
["S8832","Branebrutinib (BMS-986195)","c4","L3900-38","in 10mM DMSO","BTK","Protein Tyrosine Kinase","Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.",370.42,"1912445-55-6",{"v":74,"d":"74.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/branebrutinib.html","C20H23FN4O2","free base","N/A","CC#CC(=O)NC1CCCN(C1)C2=C3C(=C(C)[NH]C3=C(C=C2F)C(N)=O)C",3.029,2,3,4]
["S8833","TAS0728","d4","L3900-38","in 10mM DMSO","HER2","Protein Tyrosine Kinase","TAS0728 (TPC 107) is a potent, selective, orally active, irreversible and covalent-binding inhibitor of HER2 (human epidermal growth factor receptor 2) with IC50 of 13 nM. TAS0728 inihibits BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2 with IC50 of 4.9 nM, 8.5 nM, 31 nM, 65 nM, 33 nM, 25 nM, 86 nM and 36 nM, respectively. TAS0728 shows antitumor activity.",504.58,"2088323-16-2",{"v":100,"d":"100.00"},198.18,"<1","N/A","http://www.selleckchem.com/products/tas0728.html","C26H32N8O3","free base","TPC 107","CN(C)C(=O)CC1=CC=C(NC(=O)C2=N[N](C3CCCN(C3)C(=O)C=C)C4=NC=NC(=C24)N)C(=C1C)C",2.112,6,2,6]
["S8879","Deucravacitinib (BMS-986165)","e4","L3900-38","in 10mM DMSO","IFN,Interleukins,JAK","Protein Tyrosine Kinase","Deucravacitinib (BMS-986165) is a highly potent and selective allosteric inhibitor of Tyk2 with a Ki value of 0.02 nM for binding to the Tyk2 pseudokinase domain. It is highly selective against a panel of 265 kinases and pseudokinases.",425.46,"1609392-27-9",{"v":29,"d":"29.00"},68.16,"<1","N/A","http://www.selleckchem.com/products/bms-986165.html","C20H19D3N8O3","free base","N/A","C(NC(=O)C1=C(NC2=CC=CC(=C2OC)C3=N[N](C)C=N3)C=C(NC(=O)C4CC4)N=N1)([2H])([2H])[2H]",1.385,7,3,8]
["S8983","MAK683","f4","L3900-38","in 10mM DMSO","Histone Methyltransferase","Epigenetics","MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.",376.39,"1951408-58-4",{"v":20,"d":"20.00"},53.14,"<1","N/A","http://www.selleckchem.com/products/mak683.html","C20H17FN6O","free base","EED inhibitor-1","CC1=C(C=CC=N1)C2=CN=C(NCC3=C(F)C=CC4=C3CCO4)[N]5C=NN=C25",2.824,5,1,4]
["S0014","HT-2157","g4","L3900-38","in 10mM DMSO","Others","Others","HT-2157 (SNAP37889) is a selective, high-affinity, competitive antagonist of  galanin-3 receptor (Gal3).",366.34,"303149-14-6",{"v":73,"d":"73.00"},199.27,"<1","N/A","http://www.selleckchem.com/products/ht-2157.html","C21H13F3N2O","Free base","SNAP 37889","FC(F)(F)C1=CC=CC(=C1)N=C2C(=O)N(C3=CC=CC=C3)C4=C2C=CC=C4",5.232,2,0,3]
["S0037","Nidufexor (LMB-763)","h4","L3900-38","in 10mM DMSO","FXR","Metabolism","Nidufexor (LMB763) is an agonist of farnesoid X receptor (FXR).",487.93,"1773489-72-7",{"v":100,"d":"100.00"},204.95,"<1","N/A","http://www.selleckchem.com/products/nidufexor-lmb-763.html","C27H22ClN3O4","Free base","N/A","C[N]1N=C(C(=O)N(CC2=CC=CC=C2)CC3=CC=C(C=C3)C(O)=O)C4=C1C5=C(OC4)C=CC(=C5)Cl",{"v":5.33,"d":"5.330"},4,0,6]
["S0099","Asapiprant","a5","L3900-38","in 10mM DMSO","Prostaglandin Receptor","Immunology & Inflammation","Asapiprant(S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM, which has potential as a novel therapy for allergic airway diseases.",501.55,"932372-01-5",{"v":13,"d":"13.00"},25.92,"<1","N/A","http://www.selleckchem.com/products/asapiprant.html","C24H27N3O7S","Free base","S-555739","CC(C)OC1=CC=C(C=C1)[S](=O)(=O)N2CCN(CC2)C3=CC=C(C(=C3)OCC(O)=O)C4=NC=CO4",2.573,7,0,9]
["S0113","Eptapirone","b5","L3900-38","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Eptapirone (F11440) is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.The affinity (pKi) of F11440 for 5-HT1A binding sites is 8.33.",{"v":345.4,"d":"345.40"},"179756-58-2",{"v":69,"d":"69.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/eptapirone.html","C16H23N7O2","Free base","F 11440","CN1C(=O)C=NN(CCCCN2CCN(CC2)C3=NC=CC=N3)C1=O",0.572,5,0,6]
["S0164","AZD-7325","c5","L3900-38","in 10mM DMSO","GABA Receptor","Neuronal Signaling","AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of GABAAα2 and Aα3 receptor with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.",354.38,"942437-37-8",{"v":71,"d":"71.00"},200.35,"<1","N/A","http://www.selleckchem.com/products/azd-7325.html","C19H19FN4O2","Free base","N/A","CCCNC(=O)C1=C(N)C2=C(N=N1)C(=CC=C2)C3=C(OC)C=CC=C3F",3.018,4,2,5]
["S0313","Volinanserin","d5","L3900-38","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Volinanserin (Volinanserin Hydrochloride Salt, MDL100907, M 100907, MDL-100,907) is a highly selective and potent 5-HT2 receptor antagonist with Ki of 0.36 nM. Volinanserin shows antipsychotic activity.",373.46,"139290-65-6",{"v":75,"d":"75.00"},200.82,"<1","N/A","http://www.selleckchem.com/products/volinanserin.html","C22H28FNO3","Free base","Volinanserin Hydrochloride Salt, MDL100907, M 100907, MDL-100,907","COC1=C(OC)C(=CC=C1)C(O)C2CCN(CC2)CCC3=CC=C(F)C=C3",{"v":4.02,"d":"4.020"},2,1,7]
["S0338","NB 598","e5","L3900-38","in 10mM DMSO","Others","Others","NB-598 is a potent, competitive squalene epoxidase (SE) inhibitor. NB-598 suppresses cholesterol biosynthesis.",449.67,"131060-14-5",{"v":90,"d":"90.00"},200.15,"<1","N/A","http://www.selleckchem.com/products/nb-598.html","C27H31NOS2","Free base","N/A","CCN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC(=C1)OCC2=CC(=CS2)C3=CSC=C3",7.263,1,0,11]
["S0356","Pulrodemstat (CC-90011) besylate","f5","L3900-38","in 10mM DMSO","Histone Demethylase,LSD1","Methylation","Pulrodemstat (CC-90011) besylate (LSD1-IN-7 benzenesulfonate) is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.",609.64,"2097523-60-7",{"v":100,"d":"100.00"},164.03,"<1","N/A","http://www.selleckchem.com/products/cc-90011.html","C30H29F2N5O5S","Besylate","LSD1-IN-7 benzenesulfonate","COC1=C(F)C=C(C=C1)C2=C(N=C(N(C)C2=O)N3CCC(N)CC3)C4=CC(=C(C=C4)C#N)F.O[S](=O)(=O)C5=CC=CC=C5",3.467,3,1,5]
["S0428","Etalocib","g5","L3900-38","in 10mM DMSO","LTR","GPCR & G Protein","Etalocib(LY293111, VML295) is a leukotriene B4 receptor (LTB4R) antagonist that blocks activation of human neutrophils.",544.61,"161172-51-6",{"v":100,"d":"100.00"},183.62,"<1","N/A","http://www.selleckchem.com/products/ly-293111.html","C33H33FO6","Free base","LY293111, VML295","CCCC1=C(OCCCOC2=C(CC)C=C(C(=C2)O)C3=CC=C(F)C=C3)C=CC=C1OC4=CC=CC=C4C(O)=O",8.521,4,1,13]
["S0491","Manogepix (E1210)","h5","L3900-38","in 10mM DMSO","Fungal","Microbiology","Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.",358.39,"936339-60-5",{"v":72,"d":"72.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://www.selleckchem.com/products/e1210.html","C21H18N4O2","Free base","MGX, APX001A","NC1=C(C=CC=N1)C2=CC(=NO2)CC3=CC=C(COC4=CC=CC=N4)C=C3",3.673,5,1,6]
["S0504","SU14813","a6","L3900-38","in 10mM DMSO","c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","SU14813 (SU 014813) is a multiple receptor tyrosine kinase inhibitor with IC50 of 50 nM, 2 nM, 4 nM and 15 nM for VEGFR2, VEGFR1, PDGFRβ and Kit (c-Kit). SU14813 exhibits potent antiangiogenic and antitumor activity.",442.48,"627908-92-3",{"v":88,"d":"88.00"},198.88,"<1","N/A","http://www.selleckchem.com/products/su14813.html","C23H27FN4O4","Free base","SU 014813","CC1=C(C(=C([NH]1)\\C=C\\2C(=O)NC3=C2C=C(F)C=C3)C)C(=O)NCC(O)CN4CCOCC4",1.477,3,4,6]
["S0733","Tegatrabetan (BC-2059)","b6","L3900-38","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.",588.74,"1227637-23-1",{"v":100,"d":"100.00"},169.85,{"v":100,"d":"100.00"},169.85,"http://www.selleckchem.com/products/tegatrabetan.html","C28H36N4O6S2","Free base","N/A","CC1CC(C)CN(C1)[S](=O)(=O)C2=CC3=C(C=C2)C(N=O)C4=C(C=C(C=C4)[S](=O)(=O)N5CC(C)CC(C)C5)C3N=O",5.076,6,0,6]
["S0803","Danicopan (ACH-4471)","c6","L3900-38","in 10mM DMSO","Complement System","Immunology & Inflammation","Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).",580.41,"1903768-17-1",{"v":100,"d":"100.00"},172.29,"<1","N/A","http://www.selleckchem.com/products/danicopan.html","C26H23BrFN7O3","Free base","ACH-0144471, ACH-CFDIS, ALXN 2040","CC(=O)C1=N[N](CC(=O)N2CC(F)CC2C(=O)NC3=NC(=CC=C3)Br)C4=C1C=C(C=C4)C5=CN=C(C)N=C5",2.262,7,1,6]
["S0825","MDR-652","d6","L3900-38","in 10mM DMSO","TRP Channel","Transmembrane Transporters","MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity.",447.95,"1933528-96-1",{"v":90,"d":"90.00"},200.92,"<1","N/A","http://www.selleckchem.com/products/mdr-652.html","C22H23ClFN3O2S","Free base","N/A","CC(C)(C)C1=NC(=C(CNC(=O)NC2=CC(=C(CO)C=C2)F)S1)C3=CC=CC(=C3)Cl",5.082,2,3,6]
["S0851","G-1","e6","L3900-38","in 10mM DMSO","Estrogen/progestogen Receptor,GPR","GPCR & G Protein","G-1 (LNS 8801) is a nonsteroidal and selective agonist of G protein-coupled receptor 30 (GPR30, G protein-coupled estrogen receptor 1, GPER) with Ki of 11 nM.",412.28,"881639-98-1",{"v":82,"d":"82.00"},198.89,"<1","N/A","http://www.selleckchem.com/products/g-1.html","C21H18BrNO3","Free base","LNS 8801","CC(=O)C1=CC=C2NC(C3CC=CC3C2=C1)C4=C5OCOC5=CC(=C4)Br",4.249,3,1,2]
["S0861","Laninamivir Octanoate","f6","L3900-38","in 10mM DMSO","Influenza Virus,Neuraminidase","Immunology & Inflammation","Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity.",472.53,"203120-46-1",{"v":95,"d":"95.00"},201.05,"<1","N/A","http://www.selleckchem.com/products/laninamivir-octanoate.html","C21H36N4O8","Free base","CS-8958, R-118958, Inavir, LANI","CCCCCCCC(=O)OCC(O)C(OC)C1OC(=CC(N=C(N)N)C1NC(C)=O)C(O)=O",{"v":0.34,"d":"0.340"},7,4,15]
["S0872","ASTX-029","g6","L3900-38","in 10mM DMSO","ERK","MAPK","ASTX-029 is an orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. ASTX-029 inhibits ERK-dependent tumor cell proliferation and survival.",584.04,"2095719-92-7",{"v":100,"d":"100.00"},171.22,"<1","N/A","http://www.selleckchem.com/products/astx-029.html","C29H31ClFN5O5","Free base","N/A","COC1=CC(=CC(=C1)C(CO)NC(=O)C(C)N2CC3=CC=C(C=C3C2=O)C4=NC(=NC=C4Cl)NC5CCOCC5)F",2.806,6,3,9]
["S0878","AT-001","h6","L3900-38","in 10mM DMSO","Aldose Reductase","Metabolism","AT-001 (Aldose reductase-IN-1) is an aldose reductase inhibitor with IC50 of 28.9 pM.",421.35,"1355612-71-3",{"v":84,"d":"84.00"},199.36,"<1","N/A","http://www.selleckchem.com/products/at-001.html","C17H10F3N5O3S","Free base","Aldose reductase-IN-1","OC(=O)CC1=NN(CC2=NC3=CC(=CC=C3S2)C(F)(F)F)C(=O)C4=NC=CN=C14",2.208,6,0,5]
["S1217","Cyclophosphamide","a7","L3900-38","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.",261.09,"50-18-0",{"v":52,"d":"52.00"},199.17,{"v":43,"d":"43.00"},164.69,"http://www.selleckchem.com/products/Clafen.html","C7H15Cl2N2O2P","Free base","NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane","ClCCN(CCCl)[P]1(=O)NCCCO1",0.144,2,1,5]
["S1522","Tosedostat (CHR2797)","b7","L3900-38","in 10mM DMSO","Aminopeptidase","Metabolism","Tosedostat (CHR2797) is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively, and does not effectively inhibit either PILSAP, MetAP-2, LTA4 hydrolase, or MetAP-2. Phase 2.",406.47,"238750-77-1",{"v":51,"d":"51.00"},125.47,"<1","N/A","http://www.selleckchem.com/products/CHR-2797(Tosedostat).html","C21H30N2O6","Free base","N/A","CC(C)CC(C(O)C(=O)NO)C(=O)NC(C(=O)OC1CCCC1)C2=CC=CC=C2",2.406,4,3,10]
["S1575","RO4929097","c7","L3900-38","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.",{"v":469.4,"d":"469.40"},"847925-91-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://www.selleckchem.com/products/RO4929097.html","C22H20F5N3O3","Free base","RG-4733","CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)NC1C(=O)NC2=CC=CC=C2C3=C1C=CC=C3",3.184,3,3,6]
["S2211","AG-13958","d7","L3900-38","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD).",{"v":467.5,"d":"467.50"},"319460-94-1",{"v":94,"d":"94.00"},201.07,"<1","N/A","http://www.selleckchem.com/products/ag-13958.html","C26H22FN7O","Free base","AG-013958","C[N]1N=C(C)C=C1C(=O)NC2=CC(=CC=C2F)NC3=CC4=C(C=C3)C(=N[NH]4)\\C=C\\C5=CC=CC=N5",{"v":4.93,"d":"4.930"},4,3,6]
["S2221","Apatinib (YN968D1) mesylate","e7","L3900-38","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.",493.58,"1218779-75-9",{"v":22,"d":"22.00"},44.57,"<1","N/A","http://www.selleckchem.com/products/Apatinib-YN968D1.html","C25H27N5O4S","Mesylate","YN968D1, Rivoceranib","C[S](O)(=O)=O.O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=CC=CN=C3NCC4=CC=NC=C4",3.164,3,2,6]
["S2345","Podophyllotoxin (Podofilox)","f7","L3900-38","in 10mM DMSO","5-alpha Reductase","Angiogenesis","Podophyllotoxin (Condylox,Podofilox) is a lignan (lignans) found in podophyllin resin from the roots of podophyllum plants.",414.41,"518-28-5",{"v":83,"d":"83.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/Podophyllotoxin(Podofilox).html","C22H22O8","Free base","Condylox,Podofilox","COC1=C(OC)C(=CC(=C1)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24)OC",2.111,7,1,4]
["S2653","9-amino-CPT (9-Aminocamptothecin)","g7","L3900-38","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.",363.37,"91421-43-1",{"v":25,"d":"25.00"},{"v":68.8,"d":"68.80"},"<1","N/A","http://www.selleckchem.com/products/9-amino-cpt.html","C20H17N3O4","Free base","9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=C(N)C5=C4)C2=O",0.999,4,1,1]
["S2733","AV-412 free base","h7","L3900-38","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AV-412 free base (MP-412 free base) is an EGFR inhibitor with IC50s of 0.75, 0.51, 0.79, 2.30, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.",{"v":507,"d":"507.00"},"451492-95-8",{"v":100,"d":"100.00"},197.24,"<1","N/A","http://www.selleckchem.com/products/av-412-free-base.html","C27H28ClFN6O","Free base","MP-412 free base","CN1CCN(CC1)C(C)(C)C#CC2=CC3=C(C=C2NC(=O)C=C)C(=NC=N3)NC4=CC(=C(F)C=C4)Cl",5.369,3,2,7]
["S2815","Lixivaptan (VPA-985)","a8","L3900-38","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Lixivaptan (VPA-985, CRTX 080, WAY VPA 985) is an oral, non-peptide, selective V2 receptor vasopressin antagonist with IC50s of 1.2 nM and 2.3 nM for human V2 receptor and rat V2 receptor, respectively.",473.93,"168079-32-1",{"v":95,"d":"95.00"},200.45,"<1","N/A","http://www.selleckchem.com/products/lixivaptan.html","C27H21ClFN3O2","Free base","CRTX 080, WAY VPA 985","CC1=C(C=C(F)C=C1)C(=O)NC2=CC(=C(C=C2)C(=O)N3CC4=CC=C[N]4CC5=CC=CC=C35)Cl",5.676,2,1,3]
["S2975","CarboxyaMidotriazole orotate","b8","L3900-38","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate inhibits angiogenesis, tumor growth, invasion, and metastasis.",580.76,"187739-60-2",{"v":25,"d":"25.00"},43.05,"<1","N/A","http://www.selleckchem.com/products/carboxyamidotriazole-orotate.html","C22H16Cl3N7O6","Orotate","L-651582 Orotate, CAI Orotate","NC(=O)C1=C(N)[N](CC2=CC(=C(C(=C2)Cl)C(=O)C3=CC=C(Cl)C=C3)Cl)N=N1.OC(=O)C4=CC(=O)NC(=O)N4",{"v":2.65,"d":"2.650"},7,4,6]
["S3020","Romidepsin","c8","L3900-38","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.",{"v":540.7,"d":"540.70"},"128517-07-7",{"v":10,"d":"10.00"},18.49,"<1","N/A","http://www.selleckchem.com/products/Romidepsin-FK228.html","C24H36N4O6S2","Free base","FK228, Depsipeptide, FR 901228, NSC 630176,","C\\C=C1/NC(=O)C2CSSCC/C=C/C(CC(=O)NC(C(C)C)C(=O)N2)OC(=O)C(NC1=O)C(C)C",1.689,6,4,2]
["S3395","Tegobuvir","d8","L3900-38","in 10mM DMSO","HCV Protease","Proteases","Tegobuvir (TGV, GS 333126, GS-9190) is a non-nucleoside inhibitor of HCV RNA replication with proven antiviral activity in HCV-infected patients.",{"v":517.4,"d":"517.40"},"1000787-75-6",{"v":100,"d":"100.00"},193.27,"<1","N/A","http://www.selleckchem.com/products/tegobuvir.html","C25H14F7N5","Free base","TGV, GS 333126, GS-9190","FC1=CC=CC=C1C2=NC3=C[N](CC4=CC=C(N=N4)C5=CC=C(C=C5C(F)(F)F)C(F)(F)F)C=CC3=N2",6.953,4,0,6]
["S3494","Vicriviroc maleate","e8","L3900-38","in 10mM DMSO","CCR,HIV Protease","GPCR & G Protein","Vicriviroc maleate(SCH-417690 maleate,SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells.",{"v":649.7,"d":"649.70"},"599179-03-0",{"v":100,"d":"100.00"},153.92,{"v":50,"d":"50.00"},76.96,"http://www.selleckchem.com/products/vicriviroc-maleate.html","C32H42F3N5O6","Maleate","SCH-417690 maleate, SCH-D maleate","COCC(N1CCN(CC1C)C2(C)CCN(CC2)C(=O)C3=C(C)N=CN=C3C)C4=CC=C(C=C4)C(F)(F)F.OC(=O)\\C=C/C(O)=O",-2.926,6,0,9]
["S3510","NLX-101","f8","L3900-38","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors.",394.85,"635323-95-4",{"v":79,"d":"79.00"},200.08,"<1","N/A","http://www.selleckchem.com/products/nlx-101.html","C19H21ClF2N4O","Free base","F-15599","CC1=CN=C(CNCC2(F)CCN(CC2)C(=O)C3=CC(=C(F)C=C3)Cl)N=C1",2.124,3,1,5]
["S4614","PNPP","g8","L3900-38","in 10mM DMSO","Dyes","Others","PNPP (p-nitrophenyl phosphonate) is a substrate for alkaline and acid phosphatases used in enzyme-linked immunoassay (ELISA) and conventional spectrophotometric assays.",263.05,"4264-83-9",{"v":3,"d":"3.00"},{"v":11.4,"d":"11.40"},{"v":53,"d":"53.00"},201.48,"http://www.selleckchem.com/products/pnpp.html","C6H4NNa2O6P","Free base","p-nitrophenyl phosphonate","[Na+].[Na+].[O-][N+](=O)C1=CC=C(O[P]([O-])([O-])=O)C=C1",{"v":-0.95,"d":"-0.950"},1,0,3]
["S5218","Iodixanol","h8","L3900-38","in 10mM DMSO","Others","Others","Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.",1550.18,"92339-11-2",{"v":100,"d":"100.00"},64.51,"<1","N/A","http://www.selleckchem.com/products/iodixanol.html","C35H44I6N6O15","Free base","N/A","CC(=O)N(CC(O)CN(C(C)=O)C1=C(I)C(=C(I)C(=C1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)C2=C(I)C(=C(I)C(=C2I)C(=O)NCC(O)CO)C(=O)NCC(O)CO",-2.279,6,13,22]
["S6145","PF-05221304","a9","L3900-38","in 10mM DMSO","Acetyl-CoA carboxylase","Metabolism","PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).",502.56,"1370448-25-1",{"v":100,"d":"100.00"},198.98,"<1","N/A","http://www.selleckchem.com/products/pf-05221304.html","C28H30N4O5","Free base","NSC 170984, R 6238, STAT5 Inhibitor III","COC1=CC(=CC(=N1)C2=CC=C(C=C2)C(O)=O)C(=O)N3CCC4(CC3)CC(=O)C5=C(C4)C=N[N]5C(C)C",3.846,6,0,5]
["S6549","PBTZ169","b9","L3900-38","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.",456.48,"1377239-83-2",{"v":5,"d":"5.00"},10.95,"<1","N/A","http://www.selleckchem.com/products/pbtz169.html","C20H23F3N4O3S","Free base","macozinone","FC(F)(F)C1=CC(=C2SC(=NC(=O)C2=C1)N3CCN(CC3)CC4CCCCC4)[N;v5](=O)=O",5.219,2,0,5]
["S6594","Liarozole dihydrochloride","c9","L3900-38","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Liarozole Dihydrochloride is identified as a modest inhibitor of P450 with IC50 of 2.2–6.0 μM and 260 nM for CYP26 and rat CYP17 respectively.",381.69,"1883548-96-6",{"v":76,"d":"76.00"},199.11,{"v":76,"d":"76.00"},199.11,"http://www.selleckchem.com/products/liarozole-dihydrochloride.html","C₁₇H₁₅Cl₃N₄","Dihydrochloride","N/A","Cl.Cl.ClC1=CC=CC(=C1)C([N]2C=CN=C2)C3=CC4=C(C=C3)N=C[NH]4",4.062,2,1,3]
["S6672","PF-05175157","d9","L3900-38","in 10mM DMSO","Acetyl-CoA carboxylase","Metabolism","PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively.",405.49,"1301214-47-0",{"v":30,"d":"30.00"},73.98,"<1","N/A","http://www.selleckchem.com/products/pf-05175157.html","C23H27N5O2","Free base","N/A","CC(C)[N]1N=CC2=C1C(=O)CC3(CCN(CC3)C(=O)C4=CC=C5N=C(C)[NH]C5=C4)C2",2.674,4,1,2]
["S6731","Eliprodil (SL-820715)","e9","L3900-38","in 10mM DMSO","NMDAR","Neuronal Signaling","Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM.",347.85,"119431-25-3",{"v":15,"d":"15.00"},43.12,"<1","N/A","http://www.selleckchem.com/products/eliprodil.html","C20H23ClFNO","Free base","N/A","OC(CN1CCC(CC1)CC2=CC=C(F)C=C2)C3=CC=C(Cl)C=C3",{"v":4.92,"d":"4.920"},0,1,5]
["S6757","NVR 3-778","f9","L3900-38","in 10mM DMSO","Others","Others","NVR 3-778, belonging to the SBA (sulfamoylbenzamide) class, is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator). NVR 3-778 exhibits anti-HBV activity.",432.39,"1445790-55-5",{"v":98,"d":"98.00"},226.65,"<1","N/A","http://www.selleckchem.com/products/nvr-3-778.html","C18H16F4N2O4S","Free base","N/A","OC1CCN(CC1)[S;v6](=O)(=O)C2=CC(=CC=C2F)C(=O)NC3=CC(=C(F)C(=C3)F)F",1.986,3,2,4]
["S6767","GSK805","g9","L3900-38","in 10mM DMSO","Others","Others","GSK805 (JNJ 56914845, GSK-2336805) is a potent and orally bioavailable RORγt inhibitor.",532.36,"1426802-50-7",{"v":100,"d":"100.00"},187.84,"<1","N/A","http://www.selleckchem.com/products/gsk805.html","C23H18Cl2 F3NO4S","Free base","JNJ 56914845, GSK-2336805","CC[S](=O)(=O)C1=CC=C(CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl)C=C1",7.491,4,1,8]
["S6839","MRX-2843","h9","L3900-38","in 10mM DMSO","FLT3,Mertk","Protein Tyrosine Kinase","MRX-2843 (UNC2371) is an orally active dual inhibitor of tyrosine kinases MERTK and FLT3 with IC50 of 1.3 nM and 0.64 nM, respectively.",488.67,"1429882-07-4",{"v":98,"d":"98.00"},200.54,"<1","N/A","http://www.selleckchem.com/products/mrx-2843.html","C29H40N6O","Free base","UNC2371","CN1CCN(CC1)CC2=CC=C(C=C2)C3=C[N](C4CCC(O)CC4)C5=NC(=NC=C35)NCCC6CC6",4.459,2,2,8]
["S6897","Epertinib hydrochloride","a10","L3900-38","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4 with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity.",596.48,"2071195-74-7",{"v":100,"d":"100.00"},167.65,"<1","N/A","http://www.selleckchem.com/products/epertinib-hydrochloride.html","C30H28Cl2FN5O3","Hydrochloride","Epertinib HCl, S-222611 hydrochloride, S-222611 HCl","Cl.CC#CC(=N\\OCC1COCCN1)/C2=CC3=C(C=C2)N=CN=C3NC4=CC=C(OCC5=CC(=CC=C5)F)C(=C4)Cl",6.684,6,2,10]
["S6961","Foxy-5","b10","L3900-38","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Foxy-5, a Wnt-5a mimicking hexapeptide, is a WNT signalling pathway modulator potentially for the treatment of metastatic breast cancer, prostate cancer and colorectal cancer.",694.77,"881188-51-8",{"v":100,"d":"100.00"},143.93,"<1","N/A","http://www.selleckchem.com/products/foxy5.html","C26H42N6O12S2","Free base","N/A","CSCCC(NC=O)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CS)C(=O)NC(CCC(O)=O)C(=O)NC(CC(C)C)C(O)=O",-2.779,9,6,23]
["S6984","Dianhydrogalactitol (VAL-083)","c10","L3900-38","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.",146.14,"23261-20-3",{"v":29,"d":"29.00"},198.44,{"v":29,"d":"29.00"},198.44,"http://www.selleckchem.com/products/dianhydrogalactitol-val-083.html","C6H10O4","Free base","Dianhydrodulcitol, Dulcitol Diepoxide","OC(C(O)C1CO1)C2CO2",-1.408,2,2,3]
["S7023","Z-VAD-FMK","d10","L3900-38","in 10mM DMSO","Caspase","Apoptosis","Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.",467.49,"187389-52-2",{"v":93,"d":"93.00"},198.93,"<1","N/A","http://www.selleckchem.com/products/z-vad-fmk.html","C22H30FN3O7","Free base","Z-VAD(OMe)-FMK","COC(=O)CC(NC(=O)C(C)NC(=O)C(NC(=O)OCC1=CC=CC=C1)C(C)C)C(=O)CF",1.472,7,3,14]
["S7109","Pevonedistat (MLN4924)","e10","L3900-38","in 10mM DMSO","E1 Activating","Ubiquitin","MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.",443.52,"905579-51-3",{"v":88,"d":"88.00"},198.41,"<1","N/A","http://www.selleckchem.com/products/mln-4924.html","C21H25N5O4S","Free base","N/A","N[S;v6](=O)(=O)OCC1CC(CC1O)[N]2C=CC3=C(NC4CCC5=CC=CC=C45)N=CN=C23",1.543,3,3,6]
["S7455","Resatorvid (TAK-242)","f10","L3900-38","in 10mM DMSO","Autophagy,Interleukins,MyD88,TLR,TNF-alpha,TRIF","Immunology & Inflammation","Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.",361.82,"243984-11-4",{"v":72,"d":"72.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/resatorvid.html","C15H17ClFNO4S","Free base","CLI-095","CCOC(=O)C1=CCCCC1[S](=O)(=O)NC2=C(Cl)C=C(F)C=C2",3.324,4,1,6]
["S7554","Ravoxertinib (GDC-0994)","g10","L3900-38","in 10mM DMSO","ERK","MAPK","Ravoxertinib (GDC-0994) is a potent, orally available  and highly selective ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1.",439.85,"1453848-26-4",{"v":87,"d":"87.00"},197.79,"<1","N/A","http://www.selleckchem.com/products/gdc-0994.html","C21H18ClFN6O2","Free base","N/A","C[N]1N=CC=C1NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)C(CO)C4=CC(=C(Cl)C=C4)F",2.798,4,2,6]
["S7736","MLN120B","h10","L3900-38","in 10mM DMSO","IκB/IKK","NF-κB","MLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive inhibitor of IkappaB kinase beta (IKKβ) with an IC50 of 45 nM for recombinant IKKβ. MLN120B does not inhibit other IKK isoforms at IC50 below 50 μM.",{"v":366.8,"d":"366.80"},"783348-36-7",{"v":73,"d":"73.00"},199.02,"<1","N/A","http://www.selleckchem.com/products/mln120b.html","C19H15ClN4O2","Free base","ML120B","COC1=C(NC(=O)C2=CC=CN=C2C)C3=C(C=C1Cl)C4=C([NH]3)C=NC=C4",2.737,4,2,3]
["S7739","Telacebec (Q203)","a11","L3900-38","in 10mM DMSO","Bacterial","Microbiology","Telacebec (Q203, IAP6) is a novel antituberculosis drug that targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. Telacebec (Q203, IAP6) is active against Mycobacterium tuberculosis H37Rv with MIC50 of 2.7 nM in culture broth medium.",557.01,"1334719-95-7",{"v":20,"d":"20.00"},35.91,"<1","N/A","http://www.selleckchem.com/products/telacebec-q203.html","C29H28ClF3N4O2","Free base","IAP6","CCC1=C([N]2C=C(Cl)C=CC2=N1)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(OC(F)(F)F)C=C5",7.887,3,1,8]
["S7791","Phorbol 12-myristate 13-acetate (PMA)","b11","L3900-38","in 10mM DMSO","PKC,S1P Receptor","Cytoskeletal Signaling","Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.",616.83,"16561-29-8",{"v":100,"d":"100.00"},162.12,"<1","N/A","http://www.selleckchem.com/products/phorbol-12-myristate-13-acetate.html","C36H56O8","Free base","12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate","CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C2C=C(C)C3=O)C4C(C)(C)C14OC(C)=O",5.923,5,1,17]
["S7926","Lifirafenib (BGB-283)","c11","L3900-38","in 10mM DMSO","EGFR,Raf","MAPK","Lifirafenib (BGB-283, Beigene-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.",478.42,"1446090-79-4",{"v":95,"d":"95.00"},198.57,"<1","N/A","http://www.selleckchem.com/products/bgb-283-bgb283.html","C25H17F3N4O3","Free base","Beigene-283","FC(F)(F)C1=CC=C2N=C([NH]C2=C1)C3C4OC5=CC=C(OC6=C7CCC(=O)N=C7NC=C6)C=C5C34",3.338,5,2,4]
["S7930","Ixabepilone (BMS-247550)","d11","L3900-38","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Ixabepilone (Azaepothilone B, BMS-247550, Ixempra, Aza-epothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.",{"v":506.7,"d":"506.70"},"219989-84-1",{"v":100,"d":"100.00"},197.36,"<1","N/A","http://www.selleckchem.com/products/ixabepilone-bms-247550.html","C27H42N2O5S","Free base","Azaepothilone B, BMS-247550, Ixempra, Aza-epothilone B","CC1CCCC2(C)OC2CC(NC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)C(/C)=C/C3=CSC(=N3)C",3.132,4,3,2]
["S8055","Lersivirine (UK-453061)","e11","L3900-38","in 10mM DMSO","Reverse Transcriptase","Microbiology","Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.",310.35,"473921-12-9",{"v":62,"d":"62.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/uk-453061-lersivirine.html","C17H18N4O2","Free base","N/A","CCC1=N[N](CCO)C(=C1OC2=CC(=CC(=C2)C#N)C#N)CC",{"v":3.02,"d":"3.020"},2,1,6]
["S8064","Midostaurin (PKC412)","f11","L3900-38","in 10mM DMSO","PKC","Cytoskeletal Signaling","Midostaurin (pkc412, CGP 41251) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.",570.64,"120685-11-2",{"v":100,"d":"100.00"},175.24,"<1","N/A","http://www.selleckchem.com/products/midostaurin-pkc412.html","C35H30N4O4","Free base","CGP 41251","COC1C(CC2OC1(C)[N]3C4=C(C=CC=C4)C5=C3C6=C(C7=C(C=CC=C7)[N]26)C8=C5CNC8=O)N(C)C(=O)C9=CC=CC=C9",5.279,4,1,3]
["S8220","INCB3344","g11","L3900-38","in 10mM DMSO","CCR","GPCR & G Protein","INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.",577.59,"1262238-11-8",{"v":100,"d":"100.00"},173.13,"<1","N/A","http://www.selleckchem.com/products/incb3344.html","C29H34F3N3O6","Free base","N/A","CCOC1CN(CC1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)C3CCC(O)(CC3)C4=CC=C5OCOC5=C4",3.102,5,2,9]
["S8341","TAK-243 (MLN7243)","h11","L3900-38","in 10mM DMSO","Apoptosis related,E1 Activating,NF-κB","Ubiquitin","TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NFκB pathway activation and promotes apoptosis.",519.52,"1450833-55-2",{"v":100,"d":"100.00"},192.49,"<1","N/A","http://www.selleckchem.com/products/tak-243-mln243.html","C19H20F3N5O5S2","Free base","N/A","N[S;v6](=O)(=O)OCC1CC(NC2=CC=NC3=CC(=N[N]23)C4=CC(=CC=C4)SC(F)(F)F)C(O)C1O",2.805,3,4,8]
["S8524","Edicotinib(JNJ-40346527)","a2","L3900-39","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM.",{"v":461.6,"d":"461.60"},"1142363-52-7",{"v":92,"d":"92.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/edicotinib.html","C27H35N5O2","Free base","N/A","CC1(C)CCC(=CC1)C2=NC(=CC=C2NC(=O)C3=NC=C([NH]3)C#N)C4CC(C)(C)OC(C)(C)C4",{"v":4.56,"d":"4.560"},4,2,4]
["S8531","Zimlovisertib (PF-06650833)","b2","L3900-39","in 10mM DMSO","IRAK","Immunology & Inflammation","Zimlovisertib (PF-06650833) is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM.",361.37,"1817626-54-2",{"v":72,"d":"72.00"},199.24,"<1","N/A","http://www.selleckchem.com/products/pf-06650833.html","C18H20FN3O4","Free base","N/A","CCC1C(COC2=NC=CC3=CC(=C(OC)C=C23)C(N)=O)NC(=O)C1F",1.506,5,2,6]
["S8532","ARV-771","c2","L3900-39","in 10mM DMSO","PROTAC","Others","ARV-771 is a potent pan-(bromodomain and extra-terminal)BET degrader, a novel BET-PROTAC(proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.",986.64,"1949837-12-0",{"v":100,"d":"100.00"},101.35,"<1","N/A","http://www.selleckchem.com/products/arv-771.html","C49H60ClN9O7S2","Free base","N/A","CC(NC(=O)C1CC(O)CN1C(=O)C(NC(=O)COCCCOCCNC(=O)CC2N=C(C3=CC=C(Cl)C=C3)C4=C(SC(=C4C)C)[N]5C(=NN=C25)C)C(C)(C)C)C6=CC=C(C=C6)C7=C(C)N=CS7",4.176,10,4,19]
["S8535","Galicaftor (ABBV-2222)","d2","L3900-39","in 10mM DMSO","CFTR","Transmembrane Transporters","Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF).",559.46,"1918143-53-9",{"v":100,"d":"100.00"},178.74,"<1","N/A","http://www.selleckchem.com/products/abbv-2222.html","C28H21F4NO7","Free base","GLPG2222","OC(=O)C1=CC=C(C=C1)C2CC(NC(=O)C3(CC3)C4=CC=C5OC(F)(F)OC5=C4)C6=C(O2)C=C(OC(F)F)C=C6",6.907,6,1,7]
["S8563","TVB-3664","e2","L3900-39","in 10mM DMSO","Fatty Acid Synthase","Metabolism","TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.",468.47,"2097262-58-1",{"v":94,"d":"94.00"},200.65,"<1","N/A","http://www.selleckchem.com/products/tvb-3664.html","C25H23F3N4O2","Free base","N/A","COCC1=C([NH]C(=N1)C(F)(F)F)C2=C(C)C=C(C)C(=C2)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N",4.522,3,1,6]
["S8600","Elenbecestat","f2","L3900-39","in 10mM DMSO","BACE","Neuronal Signaling","Elenbecestat (E2609) is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing.",437.44,"1388651-30-6",{"v":87,"d":"87.00"},198.88,"<1","N/A","http://www.selleckchem.com/products/elenbecestat.html","C19H18F3N5O2S","Free base","E2609","CC1OCC2(N=C(N)SCC12)C3=C(F)C=CC(=C3)NC(=O)C4=CN=C(C=N4)C(F)F",2.037,5,2,4]
["S8636","Selitrectinib (LOXO-195)","g2","L3900-39","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.",380.42,"2097002-61-2",{"v":38,"d":"38.00"},99.89,"<1","N/A","http://www.selleckchem.com/products/loxo-195.html","C20H21FN6O","Free base","BAY 2731954","CC1CCC2=C(C=C(F)C=N2)C3CCCN3C4=NC5=C(C=N[N]5C=C4)C(=O)N1",2.056,4,1,0]
["S8681","Tolinapant (ASTX660)","h2","L3900-39","in 10mM DMSO","IAP","Metabolism","Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.",539.68,"1799328-86-1",{"v":100,"d":"100.00"},185.29,"<1","N/A","http://www.selleckchem.com/products/astx660.html","C30H42FN5O3","Free base","N/A","CC1CN(CC(=O)N2CC(C)(C)C3=C2C=C(CC4=CC=C(F)C=C4)C(=N3)CO)C(CN1)CN5CCOCC5C",{"v":2.93,"d":"2.930"},3,2,7]
["S8708","AZD0364 (ATG-017)","a3","L3900-39","in 10mM DMSO","ERK","MAPK","AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2.",{"v":494.5,"d":"494.50"},"2097416-76-5",{"v":99,"d":"99.00"},{"v":200.2,"d":"200.20"},"<1","N/A","http://www.selleckchem.com/products/azd0364.html","C24H24F2N8O2","Free base","N/A","COCC1C[N]2C=C(N=C2C(=O)N1CC3=CC(=C(F)C=C3)F)C4=NC(=NC=C4C)NC5=CC=N[N]5C",3.383,6,1,7]
["S8716","Pralsetinib (BLU-667)","b3","L3900-39","in 10mM DMSO","c-RET","Apoptosis","Pralsetinib (BLU-667, CS 3009, Gavreto) is a highly potent and selective RET (c-RET) inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T).",{"v":533.6,"d":"533.60"},"2097132-94-8",{"v":100,"d":"100.00"},187.41,"<1","N/A","http://www.selleckchem.com/products/blu-667.html","C27H32FN9O2","Free base","CS 3009, Gavreto","COC1(CCC(CC1)C2=NC(=CC(=N2)NC3=N[NH]C(=C3)C)C)C(=O)NC(C)C4=CN=C(C=C4)[N]5C=C(F)C=N5",3.716,7,3,8]
["S8718","RMC-4550","c3","L3900-39","in 10mM DMSO","phosphatase","Metabolism","RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.",437.36,"2172651-73-7",{"v":100,"d":"100.00"},228.64,"<1","N/A","http://www.selleckchem.com/products/rmc-4550.html","C21H26Cl2N4O2","Free base","N/A","CC1OCC2(CCN(CC2)C3=C(CO)N=C(C(=N3)C)C4=C(Cl)C(=CC=C4)Cl)C1N",2.936,3,2,3]
["S8720","Imaradenant (AZD4635)","d3","L3900-39","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.",315.73,"1321514-06-0",{"v":63,"d":"63.00"},199.54,"<1","N/A","http://www.selleckchem.com/products/adz-4635.html","C15H11ClFN5","Free base","HTL1071","CC1=CC(=CC(=N1)Cl)C2=NN=C(N)N=C2C3=CC=C(F)C=C3",3.463,4,1,2]
["S8722","Samuraciclib hydrochloride (ICEC0942 hydrochloride)","e3","L3900-39","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.",430.97,"1805789-54-1",{"v":86,"d":"86.00"},199.55,{"v":86,"d":"86.00"},199.55,"http://www.selleckchem.com/products/icec0942-hydrochloride.html","C22H31ClN6O","Hydrochloride","CT7001 hydrochloride","Cl.CC(C)C1=C2N=C(NCC3CCNCC3O)C=C(NCC4=CC=CC=C4)[N]2N=C1",{"v":3.15,"d":"3.150"},2,4,7]
["S8782","LY3295668","f3","L3900-39","in 10mM DMSO","Aurora Kinase","Cell Cycle","LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.",489.95,"1919888-06-4",{"v":98,"d":"98.00"},200.02,"<1","N/A","http://www.selleckchem.com/products/ly3295668.html","C24H26ClF2N5O2","Free base","AK-01","CC1CC(CCN1CC2=C(F)C(=CC=C2)Cl)(CC3=NC(=CC=C3F)NC4=N[NH]C(=C4)C)C(O)=O",2.403,3,2,7]
["S8829","Subasumstat (TAK-981)","g3","L3900-39","in 10mM DMSO","SUMO","Ubiquitin","Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.",{"v":578.1,"d":"578.10"},"1858276-04-6",{"v":100,"d":"100.00"},172.98,"<1","N/A","http://www.selleckchem.com/products/tak-981.html","C25H28ClN5O5S2","Free base","N/A","CC1=C(C=C(S1)C(=O)C2=C(NC3CC(O)C(CO[S](N)(=O)=O)C3)N=CN=C2)C4NCCC5=C4C=C(Cl)C=C5",2.094,4,4,8]
["S8830","Sotorasib (AMG510)","h3","L3900-39","in 10mM DMSO","Ras","Cell Cycle","Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.",560.59,"2296729-00-3",{"v":100,"d":"100.00"},178.38,"<1","N/A","http://www.selleckchem.com/products/amg510.html","C30H30F2N6O3","Free base","N/A","CC(C)C1=C(N2C(=O)N=C(N3CCN(CC3C)C(=O)C=C)C4=CC(=C(N=C24)C5=C(F)C=CC=C5O)F)C(=CC=N1)C",5.357,5,1,5]
["S8834","GB1107","a4","L3900-39","in 10mM DMSO","Galectin","Immunology & Inflammation","GB1107 is a potent, selective, inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3.",522.32,"1978336-61-6",{"v":100,"d":"100.00"},191.45,"<1","N/A","http://www.selleckchem.com/products/gb1107.html","C20H16Cl2F3N3O4S","Free base","N/A","OCC1OC(SC2=CC=C(Cl)C(=C2)Cl)C(O)C(C1O)[N]3C=C(N=N3)C4=CC(=C(F)C(=C4)F)F",4.479,3,3,5]
["S8849","TAS4464","b4","L3900-39","in 10mM DMSO","E1 Activating","Ubiquitin","TAS4464 is a potent and highly selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. TAS4464 exhibits superior antitumor activity with prolonged target inhibition.",506.51,"1848959-10-3",{"v":100,"d":"100.00"},197.43,"<1","N/A","http://www.selleckchem.com/products/tas4464.html","C21H23FN6O6S","Free base","N/A","CCOC1=CC=CC(=C1C#CC2=C[N](C3OC(CN[S](N)(=O)=O)C(O)C3O)C4=C2C(=NC=N4)N)F",0.246,6,5,8]
["S8851","Elexacaftor (VX-445)","c4","L3900-39","in 10mM DMSO","CFTR","Transmembrane Transporters","Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity.",597.65,"2216712-66-0",{"v":100,"d":"100.00"},167.32,"<1","N/A","http://www.selleckchem.com/products/elexacaftor.html","C26H34F3N7O4S","Free base","N/A","CC1CN(C2=C(C=CC(=N2)[N]3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)N[S](=O)(=O)C4=C[N](C)N=C4C)C(C)(C)C1",5.245,7,1,9]
["S8858","GSK3368715 (EPZ019997) 3HCl","d4","L3900-39","in 10mM DMSO","PRMT","Methylation","GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.",475.92,"2227587-26-8",{"v":81,"d":"81.00"},{"v":170.2,"d":"170.20"},{"v":81,"d":"81.00"},{"v":170.2,"d":"170.20"},"http://www.selleckchem.com/products/gsk3368715.html","C20H41Cl3N4O2","Trihydrochloride","N/A","Cl.Cl.Cl.CCOCC1(CCC(CC1)C2=N[NH]C=C2CN(C)CCNC)COCC",3.296,3,2,12]
["S8860","Cintirorgon (LYC-55716)","e4","L3900-39","in 10mM DMSO","ROR","Metabolism","Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.",603.53,"2055536-64-4",{"v":100,"d":"100.00"},165.69,"<1","N/A","http://www.selleckchem.com/products/cintirorgon-lyc-55716.html","C27H23F6NO6S","Free base","N/A","CC(C)(CC1CN(C2=CC(=CC=C2O1)C3=CC(=CC(=C3)F)OC(F)F)[S;v6](=O)(=O)C4=CC(=CC=C4)C(F)(F)F)C(O)=O",6.756,5,0,9]
["S8869","UNBS5162","f4","L3900-39","in 10mM DMSO","CXCR","Immunology & Inflammation","UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity (IC50 range of 0.5-5 µM) against a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7).",326.35,"956590-23-1",{"v":17,"d":"17.00"},52.09,"<1","N/A","http://www.selleckchem.com/products/unbs5162.html","C17H18N4O3","Free base","N/A","CN(C)CCN1C(=O)C2=CC=CC3=C2C(=CC(=C3)NC(N)=O)C1=O",0.819,3,2,4]
["S8881","DS-1001b (DS 1001)","g4","L3900-39","in 10mM DMSO","Dehydrogenase","Metabolism","DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier.",608.92,"1898207-64-1",{"v":14,"d":"14.00"},22.99,"<1","N/A","http://www.selleckchem.com/products/ds-1001b.html","C29H29Cl3FN3O4","Free base","DS-1001","CC1=C[N](C(=O)C2=C(ON=C2C3=C(Cl)C=C(Cl)C=C3Cl)C(C)(C)F)C4=CC=CC(=C14)\\C=C\\C(O)=O.CC(C)(C)N",{"v":5.77,"d":"5.770"},4,1,5]
["S8884","Adagrasib (MRTX849)","h4","L3900-39","in 10mM DMSO","Ras","Cell Cycle","Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling.",604.12,"2326521-71-3",{"v":100,"d":"100.00"},165.53,"<1","N/A","http://www.selleckchem.com/products/mrtx849.html","C32H35ClFN7O2","Free base","N/A","CN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=C4C(=CC=C5)Cl)C(=N2)N6CCN(C(CC#N)C6)C(=O)C(F)=C",5.325,4,0,7]
["S8890","MK-8719","a5","L3900-39","in 10mM DMSO","OGA","Autophagy","MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA.",268.28,"1382799-40-7",{"v":54,"d":"54.00"},201.28,{"v":54,"d":"54.00"},201.28,"http://www.selleckchem.com/products/mk-8719.html","C9H14F2N2O3S","Free base","N/A","CCNC1=NC2C(O)C(O)C(OC2S1)C(F)F",0.439,2,3,3]
["S8925","Simurosertib","b5","L3900-39","in 10mM DMSO","CDK","Cell Cycle","Simurosertib (TAK-931), an oral cell division cycle 7 (CDC7)-selective inhibitor with an IC50<0.3 nM, induces S phase delay and replication stress and causes mitotic aberrations through centrosome dysregulation and chromosome missegregation, resulting in irreversible antiproliferative effects in cancer cells.",341.43,"1330782-76-7",{"v":68,"d":"68.00"},199.16,"<1","N/A","http://www.selleckchem.com/products/simurosertib.html","C17H19N5OS","Free base","TAK-931","CC1=N[NH]C=C1C2=CC3=C(S2)C(=O)NC(=N3)C4CC5CCN4CC5",2.218,3,2,2]
["S8926","Valemetostat (DS-3201)","c5","L3900-39","in 10mM DMSO","EZH1/2","Methylation","Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor.",488.02,"1809336-39-7",{"v":100,"d":"100.00"},204.91,"<1","N/A","http://www.selleckchem.com/products/valemetostat-ds-3201.html","C26H34ClN3O4","Free base","DS-3201b","CN(C)C1CCC(CC1)C2(C)OC3=C(Cl)C=C(C(=O)NCC4=C(C)C=C(C)NC4=O)C(=C3O2)C",3.963,4,2,5]
["S8939","Mizagliflozin (KWA 0711)","d5","L3900-39","in 10mM DMSO","SGLT","GPCR & G Protein","Mizagliflozin (KWA 0711) is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.",564.67,"666843-10-3",{"v":100,"d":"100.00"},177.09,{"v":100,"d":"100.00"},177.09,"http://www.selleckchem.com/products/mizagliflozin.html","C28H44N4O8","Free base","N/A","CC(C)C1=C(CC2=C(C)C=C(OCCCNCC(C)(C)C(N)=O)C=C2)C(=N[NH]1)OC3OC(CO)C(O)C(O)C3O",2.007,5,7,14]
["S8942","Suramin sodium salt","e5","L3900-39","in 10mM DMSO","DNA/RNA Synthesis,Sirtuin,Topoisomerase","Metabolism","Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).",1435.23,"129-46-4",{"v":100,"d":"100.00"},69.68,{"v":100,"d":"100.00"},69.68,"http://www.selleckchem.com/products/suramin-sodium-salt.html","C51H40N6O23S6.6Na","Sodium salt","Suramin hexasodium salt","CC1=C(NC(=O)C2=CC(=CC=C2)NC(=O)NC3=CC(=CC=C3)C(=O)NC4=CC(=CC=C4C)C(=O)NC5=CC=C(C6=C5C(=CC(=C6)[S;v6](=O)(=O)O[Na])[S;v6](=O)(=O)O[Na])[S;v6](=O)(=O)O[Na])C=C(C=C1)C(=O)NC7=CC=C(C8=C7C(=CC(=C8)[S;v6](=O)(=O)O[Na])[S;v6](=O)(=O)O[Na])[S;v6](=O)(=O)O[Na]",4.993,11,6,22]
["S8955","Sotorasib (AMG510) racemate","f5","L3900-39","in 10mM DMSO","Ras","Cell Cycle","Sotorasib (AMG510) racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.",560.59,"2252403-56-6",{"v":100,"d":"100.00"},178.38,"<1","N/A","http://www.selleckchem.com/products/amg-510-racemate.html","C30H30F2N6O3","Free base","N/A","CC(C)C1=C(N2C(=O)N=C(N3CCN(CC3C)C(=O)C=C)C4=CC(=C(N=C24)C5=C(F)C=CC=C5O)F)C(=CC=N1)C",5.357,5,1,5]
["S8958","Camizestrant (AZD9833)","g5","L3900-39","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Camizestrant (AZD9833) is an orally available and selective estrogen receptor (ER) antagonist with antineoplastic activity.",476.51,"2222844-89-3",{"v":95,"d":"95.00"},199.37,"<1","N/A","http://www.selleckchem.com/products/azd9833.html","C24H28F4N6","Free base","N/A","CC1CC2=C(C=CC3=C2C=N[NH]3)C(N1CC(F)(F)F)C4=NC=C(NC5CN(CCCF)C5)C=C4",4.048,2,2,8]
["S8966","T-5224","h5","L3900-39","in 10mM DMSO","Interleukins,MMP","Proteases","T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.",517.53,"530141-72-1",{"v":100,"d":"100.00"},193.23,"<1","N/A","http://www.selleckchem.com/products/t-5224.html","C29H27NO8","Free base","N/A","OC(=O)CCC1=CC(=CC=C1OCC2=CC3=C(C=C2)C(=NO3)O)C(=O)C4=CC=C(OC5CCCC5)C=C4O",6.016,6,2,10]
["S8968","PRI-724","a6","L3900-39","in 10mM DMSO","Epigenetic Reader Domain,Wnt/beta-catenin","Stem Cells & Wnt","PRI-724 (C-82 prodrug, ICG-001 analog)  is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.",658.64,"1422253-38-0",{"v":100,"d":"100.00"},151.83,"<1","N/A","http://www.selleckchem.com/products/pri-724.html","C33H35N6O7P","Free base","C-82 prodrug, ICG-001 analog","CC1C2N(C(CC3=CC=C(O[P](O)(O)=O)C=C3)C(=O)N1CC4=CC=CC5=C4N=CC=C5)C(=O)CN(C)N2C(=O)NCC6=CC=CC=C6",2.932,5,1,8]
["S8987","TNO155","b6","L3900-39","in 10mM DMSO","phosphatase","Metabolism","TNO155 is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2 /src homology region 2 domain phosphatase /PTPN11) with IC50 of 0.011 µM. TNO155 has potential antineoplastic activity.",421.95,"1801765-04-7",{"v":84,"d":"84.00"},199.08,"<1","N/A","http://www.selleckchem.com/products/tno155.html","C18H24ClN7OS","Free base","N/A","CC1OCC2(CCN(CC2)C3=CN=C(SC4=C(Cl)C(=NC=C4)N)C(=N3)N)C1N",1.523,4,3,3]
["S8999","Exatecan Mesylate","c6","L3900-39","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Exatecan Mesylate (DX-8951f) is a water-soluble and non-pro-drug analog of camptothecin and shows significant topoisomerase I inhibition with IC50 of 0.975 μg/ml.",531.55,"169869-90-3",{"v":12.5,"d":"12.50"},23.52,{"v":12.5,"d":"12.50"},23.52,"http://www.selleckchem.com/products/exatecan-mesylate.html","C24H22FN3O4.CH4O3S","Mesylate","DX-8951 Mesylate","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C5C(N)CCC6=C5C(=CC(=C6C)F)N=C34)C2=O.C[S](O)(=O)=O",1.689,4,1,1]
["S9516","SB 265610","d6","L3900-39","in 10mM DMSO","CXCR","Immunology & Inflammation","SB265610, a competitive antagonist at the human CXCR2 receptor, can displace [125I]-IL-8 and [125I]-GROα with pIC50 values of 8.41 and 8.47 respectively, preventing receptor activation by binding to a region distinct from the agonist binding site.",357.16,"211096-49-0",{"v":71,"d":"71.00"},198.79,"<1","N/A","http://www.selleckchem.com/products/sb-265610.html","C14H9BrN6O","Free base","N/A","BrC1=CC=CC=C1NC(=O)NC2=CC=C(C#N)C3=C2[NH]N=N3",2.755,3,3,2]
["S9522","Valrubicin","e6","L3900-39","in 10mM DMSO","PKC","TGF-beta/Smad","Valrubicin(AD-32) is a chemotherapy drug used to treat bladder cancer. Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively.",723.64,"56124-62-0",{"v":100,"d":"100.00"},138.19,"<1","N/A","http://www.selleckchem.com/products/valrubicin.html","C34H36F3NO13","Free base","AD-32","CCCCC(=O)OCC(=O)C1(O)CC(OC2CC(NC(=O)C(F)(F)F)C(O)C(C)O2)C3=C(C1)C(=C4C(=O)C5=C(C(=O)C4=C3O)C(=CC=C5)OC)O",3.024,9,4,12]
["S9608","Etrumadenant (AB928)","f6","L3900-39","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Etrumadenant (AB928, A2aR/A2bR antagonist-1) is a novel dual A2aR/A2bR antagonist with Kd of 1.4 nM and 2 nM for A2aR and A2bR, respectively.",426.47,"2239273-34-6",{"v":85,"d":"85.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/ab928.html","C23H22N8O","Free base","A2aR/A2bR antagonist-1","CC1=C(C=CC=C1C#N)C2=CC(=NC(=N2)N)C3=C[N](CC4=CC=CC(=N4)C(C)(C)O)N=N3",{"v":3.75,"d":"3.750"},5,1,5]
["S9629","Elacestrant (RAD1901) Dihydrochloride","g6","L3900-39","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Elacestrant (RAD1901) Dihydrochloride is an orally available selective estrogen receptor degrader (SERD) with IC50 of 48 nM and 870 nM for ERα and ERβ, respectively.",531.56,"1349723-93-8",{"v":100,"d":"100.00"},188.13,{"v":25,"d":"25.00"},47.03,"http://www.selleckchem.com/products/elacestrant.html","C30H40Cl2N2O2","Dihydrochloride","N/A","Cl.Cl.CCNCCC1=CC=C(CN(CC)C2=C(C=CC(=C2)OC)C3CCC4=C(C3)C=CC(=C4)O)C=C1",7.434,1,2,10]
["S9650","LY3143921 hydrate","h6","L3900-39","in 10mM DMSO","CDK","Cell Cycle","LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.",327.31,"1627696-53-0",{"v":65,"d":"65.00"},198.59,"<1","N/A","http://www.selleckchem.com/products/ly3143921-hydrate.html","C16H14FN5O2","Hydrate","N/A","O.CC1(NC(=O)C2=CC(=CC=C12)C3=C[NH]N=C3)C4=NC=NC=C4F",1.219,4,2,2]
["S9676","Ropsacitinib (PF-06826647)","a7","L3900-39","in 10mM DMSO","JAK","JAK/STAT","Ropsacitinib (PF-06826647, Tyk2-IN-8, compound 10) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain. PF-06826647 (Tyk2-IN-8, compound 10) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM, respectively. PF-06826647 (Tyk2-IN-8, compound 10) is used in the treatment of psoriasis (PSO).",383.41,"2127109-84-4",{"v":77,"d":"77.00"},200.83,"<1","N/A","http://www.selleckchem.com/products/pf-06826647.html","C20H17N9","Free base","Tyk2-IN-8, compound 10","C[N]1C=C(C=N1)C2=C[N]3N=CC=C3C(=N2)C4=C[N](N=C4)C5(CC#N)CC(C5)C#N",1.315,4,0,4]
["S9691","BMS-986158","b7","L3900-39","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BMS-986158 is a potent inhibitor of BET with IC50s of 6.6 nM and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.",495.62,"1800340-40-2",{"v":25,"d":"25.00"},50.44,"<1","N/A","http://www.selleckchem.com/products/bms-986158.html","C30H33N5O2","Free base","N/A","C[N]1N=NC(=C1C2=CC3=C(N=C2)C4=C(C=C(C=C4)C(C)(C)O)[N]3C(C5CCOCC5)C6=CC=CC=C6)C",5.091,4,0,5]
["S9702","Finerenone","c7","L3900-39","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.",378.42,"1050477-31-0",{"v":76,"d":"76.00"},200.84,"<1","N/A","http://www.selleckchem.com/products/finerenone.html","C21H22N4O3","Free base","FIN, BAY 94-8862","CCOC1=NC=C(C)C2=C1C(C3=CC=C(C=C3OC)C#N)C(=C(C)N2)C(N)=O",2.613,4,2,5]
["S9726","Rimiducid (AP1903)","d7","L3900-39","in 10mM DMSO","FKBP","Apoptosis","Rimiducid (AP1903) is a chemical protein dimerizer and binds tightly to the target FKBP fusion protein while binding minimally to the abundant natural FKBP. Rimiducid elicites potent and dose-dependent apoptosis of cells in culture expressing dimerizer-dependent Fas constructs, with an EC50 of ≈0.1 nM.",1411.63,"195514-63-7",{"v":100,"d":"100.00"},70.84,"<1","N/A","http://www.selleckchem.com/products/rimiducid-ap1903.html","C78H98N4O20","Free base","N/A","CCC(C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(OC)C=C2)OC)C3=CC(=CC=C3)OCC(=O)NCCNC(=O)COC4=CC=CC(=C4)C(CCC5=CC(=C(OC)C=C5)OC)OC(=O)C6CCCCN6C(=O)C(CC)C7=CC(=C(OC)C(=C7)OC)OC)C8=CC(=C(OC)C(=C8)OC)OC",11.602,20,2,39]
["S9825","Pirtobrutinib (LOXO-305)","e7","L3900-39","in 10mM DMSO","BTK","Angiogenesis","Pirtobrutinib (LOXO-305, LY 3527727, RXC-005) is a highly selective, non-covalent, next generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells. Pirtobrutinib shows more than 300-fold selective for BTK over 98% of 370 other kinases.",479.43,"2101700-15-4",{"v":96,"d":"96.00"},200.24,"<1","N/A","http://www.selleckchem.com/products/pirtobrutinib-loxo-305.html","C22H21F4N5O3","Free base","LY 3527727, RXC-005","COC1=CC=C(F)C=C1C(=O)NCC2=CC=C(C=C2)C3=N[N](C(C)C(F)(F)F)C(=C3C(N)=O)N",3.172,4,3,8]
["S9858","Lufotrelvir (PF-07304814)","f7","L3900-39","in 10mM DMSO","COVID-19","Microbiology","PF-07304814 is a phosphate prodrug of PF-00835231 that binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174 nM.",552.51,"2468015-78-1",{"v":100,"d":"100.00"},180.99,{"v":50,"d":"50.00"},{"v":90.5,"d":"90.50"},"http://www.selleckchem.com/products/lufotrelvir-pf-07304814.html","C24H33N4O9P","Free base","N/A","COC1=CC=CC2=C1C=C([NH]2)C(=O)NC(CC(C)C)C(=O)NC(CC3CCNC3=O)C(=O)CO[P](O)(O)=O",1.036,6,4,13]
["S9866","Nirmatrelvir (PF-07321332)","g7","L3900-39","in 10mM DMSO","COVID-19,SARS-CoV","Microbiology","Nirmatrelvir (PF-07321332) is an reversible covalent inhibitor of SARS-CoV-2 main protease (Mpro, also referred to as 3CL protease) with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.",499.53,"2628280-40-8",{"v":100,"d":"100.00"},200.19,{"v":2,"d":"2.00"},{"v":4,"d":"4.00"},"http://www.selleckchem.com/products/pf-07321332.html","C23H32F3N5O4","Free base","N/A","CC(C)(C)C(NC(=O)C(F)(F)F)C(=O)N1CC2C(C1C(=O)NC(CC3CCNC3=O)C#N)C2(C)C",0.799,4,3,8]
["S9867","LY-3475070","h7","L3900-39","in 10mM DMSO","CD markers","Transmembrane Transporters","LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).",286.33,"2375815-63-5",{"v":57,"d":"57.00"},199.07,"<1","N/A","http://www.selleckchem.com/products/ly-3475070.html","C15H18N4O2","Free base","N/A","CC(C)C1CC1C2=CC(=NN=C2C)C3=CNC(=O)NC3=O",1.342,4,2,3]
["S9898","Proxalutamide (GT0918)","a8","L3900-39","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.",{"v":517.5,"d":"517.50"},"1398046-21-3",{"v":100,"d":"100.00"},193.24,"<1","N/A","http://www.selleckchem.com/products/proxalutamide-gt0918.html","C24H19F4N5O2S","Free base","N/A","CC1(C)N(C(=S)N(C1=O)C2=C(F)C(=C(C=C2)C#N)C(F)(F)F)C3=CN=C(CCCC4=NC=CO4)C=C3",5.372,4,0,7]
["S9901","KB-0742 Dihydrochloride","b8","L3900-39","in 10mM DMSO","CDK","Cell Cycle","KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.",360.33,"2416874-75-2",{"v":72,"d":"72.00"},199.82,{"v":72,"d":"72.00"},199.82,"http://www.selleckchem.com/products/kb-0742-dihydrochloride.html","C16H25N5.2ClH","Dihydrochloride","N/A","Cl.Cl.CCC(CC)C1=NC2=CC=N[N]2C(=C1)NC3CCC(N)C3",3.291,2,2,5]
["S9944","PRN1008","c8","L3900-39","in 10mM DMSO","BTK","Angiogenesis","PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.",665.76,"1575596-29-0",{"v":100,"d":"100.00"},{"v":150.2,"d":"150.20"},"<1","N/A","http://www.selleckchem.com/products/prn-008.html","C36H40FN9O3","Free base","Rilzabrutinib","CC(C)(/C=C(C#N)/C(=O)N1CCC(CC1)[N]2N=C(C3=C(F)C=C(OC4=CC=CC=C4)C=C3)C5=C2N=CN=C5N)N6CCN(CC6)C7COC7",3.758,6,1,8]
["S9970","APG-2575 (lisaftoclax)","d8","L3900-39","in 10mM DMSO","Bcl-2","Apoptosis","APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.",882.43,"2180923-05-9",{"v":100,"d":"100.00"},113.32,"<1","N/A","http://www.selleckchem.com/products/apg-2575-lisaftoclax.html","C45H48ClN7O8S","Free base","N/A","ClC1=CC=C(C=C1)C2=C(CCC3(CCC3)C2)CN4CCN(CC4)C5=CC(=C(C=C5)C(=O)N[S;v6](=O)(=O)C6=CC(=C(NCC7COCCO7)C=C6)[N;v5](=O)=O)OC8=CN=C9[NH]C=CC9=C8",7.191,7,3,13]
["S9975","ASN007","e8","L3900-39","in 10mM DMSO","ERK","MAPK","ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations.",473.93,"2055597-12-9",{"v":95,"d":"95.00"},200.45,"<1","N/A","https://www.selleckchem.com/products/asn007.html","C22H25ClFN7O2","Free base","ERAS 007,ERK-IN-3","CC1=CN=C(NC2CCOCC2)N=C1[N]3C=NC(=C3)C(=O)NC(CN)C4=CC(=CC(=C4)F)Cl",2.206,5,3,7]
["E0014","BIBO 3304 Trifluoroacetate","f8","L3900-39","in 10mM DMSO","NPY receptor","GPCR & G Protein","BIBO 3304 Trifluoroacetate (BIBO-3304 TFA) is a novel neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 values of 0.38 nM and 0.72 nM for human Y1 receptor and rat Y1 receptor, respectively. BIBO 3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor as well as for the human and rat Y5 receptor (IC50 values >1000 nM).",643.66,"191868-14-1",{"v":100,"d":"100.00"},155.36,"<1","N/A","http://www.selleckchem.com/products/bibo-3304-trifluoroacetate.html","C31H36F3N7O5","Trifluoroacetate","BIBO-3304 TFA","NC(=N)NCCCC(NC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2)C(=O)NCC3=CC=C(CNC(N)=O)C=C3.OC(=O)C(F)(F)F",2.826,4,6,15]
["E0041","Tolebrutinib (SAR442168)","g8","L3900-39","in 10mM DMSO","BTK","Angiogenesis","Tolebrutinib (SAR442168, PRN2246, BTKi'168, BTKi('168)) is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine kinase (BTK) with IC50s of 0.4 nM and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.",455.51,"1971920-73-6",{"v":91,"d":"91.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/tolebrutinib-sar442168.html","C₂₆H₂₅N₅O₃","Free base","PRN2246","NC1=NC=CC2=C1N(C(=O)N2C3CCCN(C3)C(=O)C=C)C4=CC=C(OC5=CC=CC=C5)C=C4",3.469,4,1,5]
["E0053","Evatanepag","h8","L3900-39","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Evatanepag (CP-533536 free acid) is a potent and selective EP2 receptor agonist with an IC50 of 50 nM for rEP2.",468.57,"223488-57-1",{"v":94,"d":"94.00"},200.61,"<1","N/A","http://www.selleckchem.com/products/evatanepag.html","C25H28N2O5S","Free base","CP-533536 free acid","CC(C)(C)C1=CC=C(CN(CC2=CC(=CC=C2)OCC(O)=O)[S](=O)(=O)C3=CN=CC=C3)C=C1",3.828,5,0,10]
["E0077","Simufilam","a9","L3900-39","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Simufilam(PTI-125) is a potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. Simufilam reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7nAChR.",259.35,"1224591-33-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/simufilam.html","C₁₅H₂₁N₃O","Free base","PTI-125","CN1CCC2(CC1)NCC(=O)N2CC3=CC=CC=C3",1.098,1,1,2]
["E0114","Dilmapimod (SB-681323)","b9","L3900-39","in 10mM DMSO","p38 MAPK","MAPK","Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.",456.42,"444606-18-2",{"v":91,"d":"91.00"},199.38,"<1","N/A","http://www.selleckchem.com/products/dilmapimod-sb-681323.html","C23H19F3N4O3","Free base","GW 681323","CC1=CC(=CC=C1C2=C3C=CC(=O)N(C3=NC(=N2)NC(CO)CO)C4=C(F)C=CC=C4F)F",4.124,3,3,6]
["E0121","Parsaclisib (INCB050465)","c9","L3900-39","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.",432.88,"1426698-88-5",{"v":100,"d":"100.00"},231.01,"<1","N/A","http://www.selleckchem.com/products/parsaclisib-incb050465.html","C20H22ClFN6O2","Free base","INCB-50465, IBI376","CCOC1=C(C2CNC(=O)C2)C(=C(Cl)C=C1C(C)[N]3N=C(C)C4=C(N)N=CN=C34)F",2.489,5,2,5]
["E0142","XL092","d9","L3900-39","in 10mM DMSO","Axl,c-Met,Mertk,VEGFR","Protein Tyrosine Kinase","XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.",528.53,"2367004-54-2",{"v":100,"d":"100.00"},{"v":189.2,"d":"189.20"},"<1","N/A","http://www.selleckchem.com/products/xl092.html","C29H25FN4O5","Free base","JUN04542","CNC(=O)C1=CC2=C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC5=CC=C(F)C=C5)C=C3)C=CN=C2C=C1OC",3.567,6,3,8]
["E0164","Antazoline Phosphate","e9","L3900-39","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Antazoline Phosphate is the phosphate salt of antazoline. Antazoline is a first-generation antihistaminic agent and acts as a histamine H1 receptor antagonist.",363.35,"154-68-7",{"v":18,"d":"18.00"},49.54,{"v":73,"d":"73.00"},200.91,"http://www.selleckchem.com/products/antazoline-phosphate.html","C17H19N3.H3O4P","Phosphate","N/A","O[P](O)(O)=O.C1CN=C(CN(CC2=CC=CC=C2)C3=CC=CC=C3)N1",2.246,1,1,5]
["E0357","Eliapixant","f9","L3900-39","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Eliapixant (BAY1817080) is a highly potent and selective P2X3 receptor antagonist with a mean IC50 of 8 nM.",478.49,"1948229-21-7",{"v":96,"d":"96.00"},200.63,"<1","N/A","http://www.selleckchem.com/products/eliapixant.html","C22H21F3N4O3S","Free base","BAY 1817080","CC(NC(=O)C1=CC(=CC(=C1)OC2CCOC2)C3=NC=C(C)S3)C4=CN=C(N=C4)C(F)(F)F",2.552,6,1,7]
["E0369","Endovion (NS 3728)","g9","L3900-39","in 10mM DMSO","VRAC","Transmembrane Transporters","Endovion (NS 3728, SCO-101) is a potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).",495.18,"265646-85-3",{"v":100,"d":"100.00"},201.95,"<1","N/A","http://www.selleckchem.com/products/endovion-ns-3728.html","C16H9BrF6N6O","Free base","SCO-101","FC(F)(F)C1=CC(=CC(=C1)NC(=O)NC2=CC=C(Br)C=C2C3=NN=N[NH]3)C(F)(F)F",4.185,4,3,5]
["E0499","4SC-203","h9","L3900-39","in 10mM DMSO","VEGFR","Epigenetics","4SC-203 (SC71710) is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs).",642.77,"895533-09-2",{"v":100,"d":"100.00"},155.58,"<1","N/A","http://www.selleckchem.com/products/4sc-203.html","C33H38N8O4S","Free base","SC 71710","COC1=C(NC(=O)NC2=NC3=C(S2)C=C(NC4=NC=NC5=CC(=C(OC)C=C45)OCCCN6CCN(C)CC6)C=C3)C=C(C)C=C1",5.391,7,3,11]
["E0616","Chiauranib","a10","L3900-39","in 10mM DMSO","Aurora Kinase,c-Kit,CSF-1R,PDGFR,VEGFR","Protein Tyrosine Kinase","Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.",{"v":435.5,"d":"435.50"},"1256349-48-0",{"v":87,"d":"87.00"},199.77,"<1","N/A","http://www.selleckchem.com/products/chiauranib.html","C27H21N3O3","Free base","CS2164","COC1=CC2=C(C=C1)C(=CC=N2)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=C(N)C=CC=C5",4.506,4,2,5]
["E0818","Quinupristin","b10","L3900-39","in 10mM DMSO","Others","Others","Quinupristin, a streptogramin antibiotic, blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits.",1022.22,"120138-50-3",{"v":50,"d":"50.00"},48.91,"<1","N/A","http://www.selleckchem.com/products/quinupristin.html","C53H67N9O10S","Free base","N/A","CCC1NC(=O)C(NC(=O)C2=C(O)C=CC=N2)C(C)OC(=O)C(NC(=O)C3CC(=O)C(CSC4CN5CCC4CC5)CN3C(=O)C(CC6=CC=C(C=C6)N(C)C)N(C)C(=O)C7CCCN7C1=O)C8=CC=CC=C8",2.515,10,4,10]
["E1000","Zn-C3","c10","L3900-39","in 10mM DMSO","Wee1","Cell Cycle","ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.",526.63,"2376146-48-2",{"v":100,"d":"100.00"},189.89,"<1","N/A","http://www.selleckchem.com/products/zn-c3.html","C29H34N8O2","Free base","N/A","CCC1(O)CCC2=CC=C(N=C12)N3N(CC=C)C(=O)C4=CN=C(NC5=CC=C(C=C5)N6CCN(C)CC6)N=C34",4.864,4,1,7]
["E1013","Bemnifosbuvir Hemisulfate (AT-527)","d10","L3900-39","in 10mM DMSO","SARS-CoV","Microbiology","Bemnifosbuvir Hemisulfate (AT-527, RG-6422, RO 7496998) is a hemi-sulfate salt of AT-511. AT-511 is a potent inhibitor of SARS-CoV-2 with an EC90 of 0.47 μM.",630.55,"2241337-84-6",{"v":100,"d":"100.00"},147.14,{"v":100,"d":"100.00"},147.14,"http://www.selleckchem.com/products/bemnifosbuvir-hemisulfate-at-527.html","C24H33FN7O7P.1/2H2O4S","Hemisulfate","RG-6422, RO 7496998","CNC1=C2N=C[N](C3OC(CO[P](=O)(NC(C)C(=O)OC(C)C)OC4=CC=CC=C4)C(O)C3(C)F)C2=NC(=N1)N.O[S](O)(=O)=O",1.948,8,4,12]
["E1078","Emvododstat (PTC299)","e10","L3900-39","in 10mM DMSO","Dehydrogenase,VEGFR","Protein Tyrosine Kinase","Emvododstat(PTC299), a post-transcriptional inhibitor of pathogenic VEGF and dihydroorotate dehydrogenase(DHODH), inhibits VEGFA mRNA translation and abnormal cell proliferation. In HeLa cells PTC299 inhibits hypoxia-induced VEGFA protein production with an EC50 of 1.64 nM.",467.34,"1256565-36-2",{"v":93,"d":"93.00"},{"v":199,"d":"199.00"},"<1","N/A","http://www.selleckchem.com/products/emvododstat-ptc299.html","C25H20Cl2N2O3","Free base","N/A","COC1=CC=C(C=C1)C2N(CCC3=C2[NH]C4=C3C=C(Cl)C=C4)C(=O)OC5=CC=C(Cl)C=C5",{"v":6.86,"d":"6.860"},3,1,4]
["E1091","Relacorilant","f10","L3900-39","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Relacorilant (CORT125134) is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively.",586.56,"1496510-51-0",{"v":100,"d":"100.00"},170.49,"<1","N/A","http://www.selleckchem.com/products/relacorilant.html","C27H22F4N6O3S","Free base","CORT125134","C[N]1C=C(C=N1)[S;v6](=O)(=O)N2CCC3=CC4=C(CC3(C2)C(=O)C5=CC(=CC=N5)C(F)(F)F)C=N[N]4C6=CC=C(F)C=C6",4.117,6,0,6]
["E1111","VV116","g10","L3900-39","in 10mM DMSO","COVID-19,DNA/RNA Synthesis,SARS-CoV","Microbiology","VV116, a promising orally administered anti-SARS-CoV-2 nucleoside drug candidate, exerts functions by targeting the viral RNA-dependent RNA polymerase through its nucleoside triphosphate form with an IC50 of 0.67±0.24 μM.",502.54,"2647442-33-7(free base)",{"v":100,"d":"100.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/vv116.html","C24H30DN5O7","Free base","JT001","CC(C)C(=O)OCC1OC(C#N)(C(OC(=O)C(C)C)C1OC(=O)C(C)C)C2=CC(=C3[N]2N=CN=C3N)[2H]",3.095,9,1,11]
["E1131","Ensitrelvir fumarate","h10","L3900-39","in 10mM DMSO","COVID-19,SARS-CoV","Microbiology","S-217622 (Ensitrelvir fumarate) is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor with IC50 of 13 nM.",647.95,"2757470-18-9",{"v":50,"d":"50.00"},77.17,"<1","N/A","http://www.selleckchem.com/products/s-217622.html","C22H17ClF3N9O2.C4H4O4","fumarate","S-217622 fumarate","C[N]1C=NC(=N1)CN2C(=O)NC(=NC3=CC4=C[N](C)N=C4C=C3Cl)N(CC5=C(F)C=C(F)C(=C5)F)C2=O.OC(=O)\\C=C\\C(O)=O",5.384,8,1,7]
["E1179","EZM0414","a11","L3900-39","in 10mM DMSO","SETD","Methylation","EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.",400.49,"2411748-50-8",{"v":40,"d":"40.00"},99.88,"<1","N/A","http://www.selleckchem.com/products/ezm0414.html","C22H29FN4O2","Free base","N/A","CC(=O)N1CCN(CC1)C2CCCC(C2)NC(=O)C3=CC4=C(F)C=CC(=C4[NH]3)C",2.707,2,2,3]
["E1180","Sovilnesib","b11","L3900-39","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.",564.65,"2410796-79-9",{"v":100,"d":"100.00"},{"v":177.1,"d":"177.10"},"<1","N/A","http://www.selleckchem.com/products/sovilnesib.html","C26H34F2N6O4S","Free base","AMG 650","CC1=CC(=NC(=N1)N2CCC(F)(F)CC2)NC(=O)C3=C(C=C(N[S;v6](=O)(=O)CCO)C=C3)N4CCC5(CC4)CC5",2.699,5,3,8]
["E1183","MRTX0902","c11","L3900-39","in 10mM DMSO","Others","Others","MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM.",388.47,"2654743-22-1",{"v":100,"d":"100.00"},257.42,"<1","N/A","http://www.selleckchem.com/products/mrtx0902.html","C22H24N6O","Free base","N/A","CC(NC1=NN=C(C)C2=C1C=C(N=C2)N3CCOCC3)C4=C(C)C(=CC=C4)C#N",3.315,4,1,4]
["E1184","CFT7455","d11","L3900-39","in 10mM DMSO","Others","Others","CFT7455 is an orally active zinc finger transcription factors (IKZF1) (Ikaros) and IKZF3 (Aiolos) degrader. It binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM). It is used in the treatment of multiple myeloma & non-Hodgkin’s lymphoma.",469.53,"2504235-67-8",{"v":94,"d":"94.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/cft7455.html","C28H27N3O4","Free base","N/A","O=C1CCC(N2C(=O)C3=C4C2=CC=C(CC5=CC=C(CN6CCOCC6)C=C5)C4=CC=C3)C(=O)N1",2.869,4,1,5]
["E1191","GDC-1971","e11","L3900-39","in 10mM DMSO","phosphatase","Metabolism","GDC-1971 (compound 199) is a SHP2 inhibitor.",454.54,"2377352-49-1",{"v":91,"d":"91.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/gdc-1971.html","C25H26N8O","Free base","compound 199","NC1C2=CC=CC=C2OC13CCN(CC3)C4=CN=C5C(=N4)[NH]N=C5N6CCCC7=NC=CC=C67",2.597,5,2,2]
["E1205","BAY 2666605","f11","L3900-39","in 10mM DMSO","PDE","Metabolism","BAY 2666605 is an orally active phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) inhibitor with IC50s of 87 nM and 50 nM, respectively.",352.28,"2275774-60-0",{"v":70,"d":"70.00"},198.71,"<1","N/A","http://www.selleckchem.com/products/bay-2666605.html","C17H12F4N2O2","Free base","N/A","CC1OC(=O)NN=C1C2=CC=C(C3=CC=C(F)C=C3)C(=C2)C(F)(F)F",4.479,3,1,3]
["E1208","NPX800","g11","L3900-39","in 10mM DMSO","HSP (HSP90)","Metabolism","NPX800 is a potent heat shock factor 1 (HSF1) inhibitor, which has the potential for cancer research.",569.63,"1693734-80-3",{"v":100,"d":"100.00"},175.55,"<1","N/A","http://www.selleckchem.com/products/npx800.html","C32H32FN5O4","Free base","N/A","CCN1CCN(CC1)CC2=NC3=C(C=C2)C=C(C=C3)C(=O)NC4=CC(=CC=C4F)NC(=O)C5=CC=C6OCCOC6=C5",4.171,5,2,7]
["E1212","CC-99282","h11","L3900-39","in 10mM DMSO","E3 ligase Ligand","Others","CC-99282 (Golcadomide) is an orally active cereblon (CRBN)  E3 ligase  modulator (CELMoD). Ikaros and Aiolos are degraded potently and specifically by CC-99282, which co-opts CRBN.",535.57,"2379572-34-4",{"v":100,"d":"100.00"},186.72,"<1","N/A","http://www.selleckchem.com/products/cc-99282.html","C28H30FN5O5","Free base","Golcadomide","FC1=C(CNC2=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=CC(=C1)CN5CC(C5)N6CCOCC6",1.442,5,2,7]
["E1239","Apararenone","a2","L3900-40","in 10mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Apararenone (MT-3995) is a selective, long-acting nonsteroidal mineralocorticoid receptors (MR) antagonist.",364.39,"945966-46-1",{"v":73,"d":"73.00"},200.33,"<1","N/A","https://www.selleckchem.com/products/apararenone.html","C17H17FN2O4S","Free base","MT-3995","CC1(C)OC2=CC(=CC=C2N(C1=O)C3=CC=C(F)C=C3)N[S;v6](C)(=O)=O",2.314,4,1,3]
["E1258","Pridopidine","b2","L3900-40","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pridopidine (ACR16, ASP2314, FR310826) , a dopamine (DA) stabilizer, acts as an antagonist against sigma 1 receptor (S1R) and dopamine D2 receptor (D2R).",281.42,"346688-38-8",{"v":57,"d":"57.00"},202.54,"<1","N/A","https://www.selleckchem.com/products/pridopidine.html","C15H23NO2S","Free base","ACR16, ASP2314, FR310826","CCCN1CCC(CC1)C2=CC(=CC=C2)[S;v6](C)(=O)=O",2.919,2,0,4]
["E2227","GLN-1062","c2","L3900-40","in 10mM DMSO","Others","Others","GLN-1062 (Memogain) is an inactive pro-drug of galantamine, the latter being a plant alkaloid approved for the treatment of mild to moderate Alzheimer's disease.",391.46,"224169-27-1",{"v":78,"d":"78.00"},199.25,"<1","N/A","http://www.selleckchem.com/products/gln-1062.html","C24H25NO4","Free base","Memogain","COC1=C2OC3CC(OC(=O)C4=CC=CC=C4)C=CC35CCN(C)CC(=C25)C=C1",3.485,4,0,4]
["E2399","Falnidamol","d2","L3900-40","in 10mM DMSO","EGFR,p38 MAPK","Protein Tyrosine Kinase","Falnidamol (BIBX1382) is a selective inhibitor of epidermal growth factor receptor (EGFR), exerting anti-cancer role in human head and neck squamous cell carcinomas both in vitro and in vivo through suppressing mitogen-activated protein kinases (MAPKs) signaling.",387.84,"196612-93-8",{"v":20,"d":"20.00"},51.57,"<1","N/A","http://www.selleckchem.com/products/falnidamol.html","C18H19ClFN7","Free base","BIBX1382","CN1CCC(CC1)NC2=NC=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=N2",3.437,4,2,4]
["E2404","NVP-LCQ195","e2","L3900-40","in 10mM DMSO","CDK","Cell Cycle","NVP-LCQ195 (AT9311, LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.",460.34,"902156-99-4",{"v":92,"d":"92.00"},199.85,"<1","N/A","https://www.selleckchem.com/products/nvp-lcq195.html","C17H19Cl2N5O4S","Free base","LCQ-195, AT9311","C[S;v6](=O)(=O)N1CCC(CC1)NC(=O)C2=N[NH]C=C2NC(=O)C3=C(Cl)C=CC=C3Cl",1.185,5,3,5]
["E2406","Paltusotine","f2","L3900-40","in 10mM DMSO","SSTR","Endocrinology & Hormones","Paltusotine (CRN00808) is an orally active, nonpeptide selective somatostatin type 2 (SST2) receptor agonist, has the potential for maintaining GH and IGF-1 levels after depot somatostatin receptor ligand therapy.",456.49,"2172870-89-0",{"v":91,"d":"91.00"},199.35,"<1","N/A","http://www.selleckchem.com/products/paltusotine.html","C27H22F2N4O","Free base","CRN00808","NC1CCN(CC1)C2=C(C=NC3=C2C=C(C=C3)C4=C(O)C(=CC=C4)C#N)C5=CC(=CC(=C5)F)F",4.406,1,2,3]
["E2438","Ginsenoside Rg3","g2","L3900-40","in 10mM DMSO","Others","Others","Ginsenoside Rg3 is a ginsenoside found in Panax japonicus var. and Panax ginseng, mainly used for the study of tumor diseases.",{"v":785,"d":"785.00"},"11019-45-7",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleckchem.com/products/ginsenoside-rg3.html","C42H72O13","Free base","N/A","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["E2629","Vimseltinib","h2","L3900-40","in 10mM DMSO","c-Kit,CSF-1R","Protein Tyrosine Kinase","Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.",431.49,"1628606-05-2",{"v":86,"d":"86.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/vimseltinib.html","C23H25N7O2","Free base","DCC-3014","CC(C)NC1=NC=C(C(=O)N1C)C2=CC=C(OC3=CC=NC(=C3)C4=C[N](C)N=C4)C(=N2)C",2.226,6,1,6]
["E2655","Terevalefim","a3","L3900-40","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation.",176.24,"1070881-42-3",{"v":35,"d":"35.00"},198.59,"<1","N/A","http://www.selleckchem.com/products/terevalefim.html","C9H8N2S","Free base","ANG-3777","[NH]1C=CC(=N1)\\C=C\\C2=CC=CS2",2.642,1,1,2]
["E2656","R1530","b3","L3900-40","in 10mM DMSO","FGFR,VEGFR","Angiogenesis","R1530 is a highly potent, orally bioavailable, dual-acting mitosis/angiogenesis inhibitor for the treatment of solid tumors, which can inhibit vascular endothelial growth factor receptor 2 (VEGFR2) and fibroblast growth factor receptors 1 (FGFR1) with IC50s of 10 nM and 28 nM, respectively.",356.78,"882531-87-5",{"v":71,"d":"71.00"},{"v":199,"d":"199.00"},"<1","N/A","http://www.selleckchem.com/products/r1530.html","C18H14ClFN4O","Free base","N/A","COC1=C(F)C=C2C(=C1)N=C3NNC(=C3N=C2C4=CC=CC=C4Cl)C",3.036,3,2,2]
["E2658","FN-1501","c3","L3900-40","in 10mM DMSO","CDK,FLT3","Cell Cycle","FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively.",431.49,"1429515-59-2",{"v":86,"d":"86.00"},199.31,"<1","N/A","http://www.selleckchem.com/products/fn-1501.html","C22H25N9O","Free base","N/A","CN1CCN(CC1)CC2=CC=C(NC(=O)C3=N[NH]C=C3NC4=C5C=C[NH]C5=NC=N4)C=C2",2.321,4,4,6]
["E2665","Tafenoquine","d3","L3900-40","in 10mM DMSO","Anti-infection","Others","Tafenoquine (WR 238605) is an 8-aminoquinoline, used as an anti-malarial prophylactic agent.",463.49,"106635-80-7",{"v":93,"d":"93.00"},200.65,"<1","N/A","http://www.selleckchem.com/products/tafenoquine.html","C24H28F3N3O3","Free base","WR 238605","COC1=NC2=C(C(=C1)C)C(=C(OC)C=C2NC(C)CCCN)OC3=CC(=CC=C3)C(F)(F)F",{"v":5.51,"d":"5.510"},4,2,10]
["E2821","RGB-286638 free base","e3","L3900-40","in 10mM DMSO","CDK,GSK-3,JAK,MEK,TAK1","Cell Cycle","RGB-286638 free base is a Cyclin-dependent kinase (CDK) inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.",545.63,"784210-88-4",{"v":100,"d":"100.00"},183.27,"<1","N/A","http://www.selleckchem.com/products/rgb-286638-free-base.html","C29H35N7O4","Free base","N/A","COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=N[NH]C4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6",2.022,5,3,8]
["E2822","GSK2983559 active metabolite","f3","L3900-40","in 10mM DMSO","RIP kinase","Apoptosis","GSK2983559 active metabolite is an active metabolite of GSK2983559, also is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.",458.55,"1423186-80-4",{"v":100,"d":"100.00"},218.08,"<1","N/A","http://www.selleckchem.com/products/gsk2983559-active-metabolite.html","C21H22N4O4S2","Free base","N/A","CC(C)(C)[S](=O)(=O)C1=CC2=C(NC3=CC=C4SC=NC4=C3)N=CN=C2C=C1OCCO",3.462,6,2,7]
["E2837","Zabedosertib","g3","L3900-40","in 10mM DMSO","IRAK","Immunology & Inflammation","Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential, which is a protein kinase involved in signaling innate immune responses from Toll-like receptors.",470.47,"1931994-81-8",{"v":94,"d":"94.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/zabedosertib.html","C20H21F3N4O4S","Free base","BAY 1834845","CC(C)(O)C1=CC2=N[N](CC[S;v6](C)(=O)=O)C=C2C=C1NC(=O)C3=CC=CC(=N3)C(F)(F)F",2.826,5,1,7]
["E2843","Poseltinib","h3","L3900-40","in 10mM DMSO","BTK","Angiogenesis","Poseltinib (HM71224, LY3337641) shows a highly selective inhibition for Bruton’s tyrosine kinase (BTK) with IC50 of 1.95 nM, in which the selectivity toward other BMX, TEC and TXK are 0.3, 2.3 and 2.4 fold, respectively.",470.52,"1353552-97-2",{"v":94,"d":"94.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/poseltinib.html","C26H26N6O3","Free base","HM71224, LY3337641","CN1CCN(CC1)C2=CC=C(NC3=NC(=C4OC=CC4=N3)OC5=CC(=CC=C5)NC(=O)C=C)C=C2",4.891,5,2,7]
["E2853","GSK626616","a4","L3900-40","in 10mM DMSO","DYRK","Protein Tyrosine Kinase","GSK-626616 is a  dual-specificity tyrosine-regulated kinase (DYRK3) inhibitor with an IC50 of 0.7 nM which is a potential therapy for the treatment of anemia.",401.27,"1025821-33-3",{"v":20,"d":"20.00"},49.84,"<1","N/A","https://www.selleckchem.com/products/gsk626616.html","C18H10Cl2N4OS","Free base","N/A","ClC1=C(NC2=NC(=O)C(/S2)=C/C3=CC4=C(C=C3)N=CC=N4)C(=CC=C1)Cl",4.572,4,1,3]
["P1005","Abarelix Acetate","b4","L3900-40","in 10mM DMSO","Others","Endocrinology & Hormones","Abarelix Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.",1476.12,"785804-17-3",{"v":100,"d":"100.00"},67.75,{"v":100,"d":"100.00"},67.75,"http://www.selleckchem.com/peptide/abarelix-acetate.html","C74H99ClN14O16","Acetate","Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(ipr)-Pro-D-Ala-NH2","CC(C)CC(NC(=O)C(CC(N)=O)NC(=O)C(CC1=CC=C(O)C=C1)N(C)C(=O)C(CO)NC(=O)C(CC2=CN=CC=C2)NC(=O)C(CC3=CC=C(Cl)C=C3)NC(=O)C(CC4=CC5=C(C=CC=C5)C=C4)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N6CCCC6C(=O)NC(C)C(N)=O.CC(O)=O",-0.464,14,13,38]
["P1032","CCK Octapeptide (Sincalide)","c4","L3900-40","in 10mM DMSO","Others","Others","CCK Octapeptide (Sincalide, Cholecystokinin Octapeptide, CCK-OP, CCK-8, SQ 19,844) is a endogenous peptide hormone found in the intestine and brain that stimulates digestion.",1143.27,"25126-32-3",{"v":100,"d":"100.00"},87.47,"<1","N/A","http://www.selleckchem.com/products/Sincalide(Kinevac).html","C49H62N10O16S3","Free base","Cholecystokinin Octapeptide, CCK-OP, CCK-8, SQ 19,844","CSCCC(NC(=O)C(CC1=CC=C(O[S](O)(=O)=O)C=C1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(CC2=C[NH]C3=CC=CC=C23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(CC4=CC=CC=C4)C(N)=O",-3.722,11,10,33]
["P1069","Ganirelix acetate (Antagon)","d4","L3900-40","in 10mM DMSO","Others","Endocrinology & Hormones","Ganirelix acetate (Antagon,Orgalutran) is a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH).",1690.43,"123246-29-7",{"v":100,"d":"100.00"},59.16,{"v":100,"d":"100.00"},59.16,"http://www.selleckchem.com/peptide/ganirelix-acetate-antagon.html","C80H113ClN18O13.2C2H4O2","Diacetate","Orgalutran","CCNC(NCC)=NCCCCC(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC2=CN=CC=C2)NC(=O)C(CC3=CC=C(Cl)C=C3)NC(=O)C(CC4=CC5=C(C=CC=C5)C=C4)NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN=C(NCC)NCC)C(=O)N6CCCC6C(=O)NC(C)C(N)=O.CC(O)=O.CC(O)=O",3.056,16,16,48]
["P1106","D-JNKI-1","e4","L3900-40","in 10mM DMSO","JAK","MAPK","D-JNKI-1 (AM-111, XG-102, Brimapitide) is a highly and cell-permeable peptide inhibitor of JNK.",{"v":3822.5,"d":"3822.50"},"1445179-97-4",{"v":100,"d":"100.00"},26.16,{"v":50,"d":"50.00"},13.08,"http://www.selleckchem.com/products/d-jnki-1.html","C₁₆₄H₂₈₆N₆₆O₄₀","Free base","AM-111, XG-102, Brimapitide","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2CCCN2C(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C3CCCN3C(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CCC(N)=O)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(CCCNC(N)=N)C(=O)N6CCCC6C(=O)N7CCCC7C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O",-23.996,36,54,135]
["P1109","Linaclotide","f4","L3900-40","in 10mM DMSO","Others","Others","Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist that elicits pharmacological effects locally in the gastrointestinal tract.",1526.75,"851199-59-2",{"v":100,"d":"100.00"},{"v":65.5,"d":"65.50"},"<1","N/A","http://www.selleckchem.com/products/linaclotide.html","C59H79N15O21S6","Free base","N/A","CC(O)C1NC(=O)C2CSSCC3NC(=O)C(N)CSSCC(NC(=O)C(CSSCC(NC(=O)CNC1=O)C(=O)NC(CC4=CC=C(O)C=C4)C(O)=O)NC(=O)C(CC5=CC=C(O)C=C5)NC(=O)C(CCC(O)=O)NC3=O)C(=O)NC(CC(N)=O)C(=O)N6CCCC6C(=O)NC(C)C(=O)N2",-7.707,16,17,13]
["P1144","Antide","g4","L3900-40","in 10mM DMSO","Apoptosis related,GNRH Receptor","Endocrinology & Hormones","Antide(Iturelix), a gonadotropin-releasing hormone (GNRH) antagonist, inhibits apoptosis of preovulatory follicle cells in the rat ovary.",{"v":1591.3,"d":"1591.30"},"112568-12-4",{"v":100,"d":"100.00"},62.84,{"v":50,"d":"50.00"},31.42,"http://www.selleckchem.com/products/antide.html","C82H108ClN17O14","Free base","Iturelix","CC(C)CC(NC(=O)C(CCCCNC(=O)C1=CN=CC=C1)NC(=O)C(CCCCNC(=O)C2=CN=CC=C2)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(Cl)C=C4)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N7CCCC7C(=O)NC(C)C(N)=O",{"v":2.35,"d":"2.350"},16,14,46]
["P1150","Saralasin Acetate","h4","L3900-40","in 10mM DMSO","RAAS","Endocrinology & Hormones","Saralasin Acetate, an octapeptide analog of angiotensin II, is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of hypertension.",990.11,"39698-78-7",{"v":100,"d":"100.00"},{"v":101,"d":"101.00"},{"v":100,"d":"100.00"},{"v":101,"d":"101.00"},"http://www.selleckchem.com/products/saralasin-acetate.html","C44H71N13O13","Acetate","N/A","O.CNCC(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)C)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(C(C)C)C(=O)NC(CC2=CN=C[NH]2)C(=O)N3CCCC3C(=O)NC(C)C(O)=O.CC(O)=O",-4.947,10,11,26]
["P1151","Difelikefalin","a5","L3900-40","in 10mM DMSO","Opioid Receptor","GPCR & G Protein","Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.",679.85,"1024828-77-0",{"v":100,"d":"100.00"},147.09,{"v":100,"d":"100.00"},147.09,"http://www.selleckchem.com/products/difelikefalin.html","C36H53N7O6","Free base","N/A","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C(N)CC2=CC=CC=C2)C(=O)NC(CCCCN)C(=O)N3CCC(N)(CC3)C(O)=O",-1.787,5,6,18]
["P1208","PMX 205","b5","L3900-40","in 10mM DMSO","CD markers","Transmembrane Transporters","PMX 205 is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.",839.04,"514814-49-4",{"v":100,"d":"100.00"},119.18,{"v":50,"d":"50.00"},59.59,"http://www.selleckchem.com/products/pmx-205.html","C45H62N10O6","Free base","N/A","NC(N)=NCCCC1NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CC4CCCCC4)NC(=O)C5CCCN5C(=O)C(CCCNC1=O)NC(=O)CCC6=CC=CC=C6",3.088,7,8,12]
["E4048","Phenyl acetate","c5","L3900-40","in 10mM DMSO","Others","Others","Phenyl acetate, the ester of a phenol and acetic acid, can be produced by reacting acetic anhydride with phenol. Another way is produced by decarboxylation of aspirin.",136.15,"122-79-2","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/phenyl-acetate.html","C8H8O2","free base","Phenyl acetate","CC(=O)OC1=CC=CC=C1",1.597,2,0,2]
["E4110","Myrcene","d5","L3900-40","in 10mM DMSO","Others","Others","Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.",136.23,"123-35-3","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/myrcene.html","C10H16","free base","Myrcene","CC(C)=CCCC(=C)C=C",3.687,0,0,4]
["E4112","Menthol","e5","L3900-40","in 10mM DMSO","Others","Others","Menthyl alcohol is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.",156.26,"1490-04-6","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/menthol.html","C10H20O","free base","Menthyl alcohol","CC(C)C1CCC(C)CC1O",2.779,0,1,1]
["E4118","(-)-Menthone","f5","L3900-40","in 10mM DMSO","Others","Others","(-)-Menthone is a natural product.",154.25,"14073-97-3","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/-menthone.html","C10H18O","free base","(-)-Menthone","CC(C)C1CCC(C)CC1=O",2.736,1,0,1]
["E4175","(±)-Naringenin","g5","L3900-40","in 10mM DMSO","Potassium Channel","Potassium Channel","(±)-Naringenin is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.",272.25,"67604-48-2","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/naringenin.html","C15H12O5","free base","(±)-Naringenin","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["E4234","1-Octanol","h5","L3900-40","in 10mM DMSO","calcium channel; Endogenous Metabolite","Membrane transporter/Ion channel; Metabolism","1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2].",130.23,"111-87-5","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/1-octanol.html","C8H18O","free base","1-Octanol","CCCCCCCCO",2.795,0,1,6]
["E4265","Pyrimidine","a6","L3900-40","in 10mM DMSO","Others","Others","Pyrimidines are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and thymidine respectively), or deoxyribose-containing deoxynucleosides, and their corresponding ribonucleotides or deoxyribonucleotides. Pyrimidines serve essential functions in human metabolism as ribonucleotide bases in RNA (uracil and cytosine), and as deoxyribonucleotide bases in DNA (cytosine and thymine), and are linked by phosphodiester bridges to purine nucleotides in double-stranded DNA, in both the nucleus and the mitochondria. Pyrimidine activated sugars are also involved in polysaccharide and phospholipid synthesis, glucuronidation in detoxification processes, glycosylation of proteins and lipids and in the recently identified novel endothelium-derived vasoactive dinucleotides.",80.09,"289-95-2","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/pyrimidine.html","C4H4N2","free base","Pyrimidine","C1=CN=CN=C1",0.051,2,0,0]
["E4324","1,3-BUTANEDIOL","b6","L3900-40","in 10mM DMSO","Endogenous Metabolite","Metabolism","1,3-Butanediol (BD) is a ketogenic substance. Ketone bodies are essential energy substrates in the absence of exogenous nutrients, and more recently, they have been suggested to prevent disease and improve longevity.",90.12,"107-88-0","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/1-3-butanediol.html","C4H10O2","free base","1,3-BUTANEDIOL","CC(O)CCO",-0.458,0,2,2]
["E4354","Phenylethyl isothiocyanate","c6","L3900-40","in 10mM DMSO","HDAC","Chromatin/Epigenetic; DNA Damage/DNA Repair","Phenylethyl isothiocyanate is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.",163.23,"2257-09-2","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/phenylethyl-isothiocyanate.html","C9H9NS","free base","Phenylethyl isothiocyanate","S=C=NCCC1=CC=CC=C1",2.917,1,0,3]
["E4029","Tyramine hydrochloride","d6","L3900-40","in 10mM DMSO","Others","Others","Tyramine hydrochloride is a biogenic trace amine that is generated via the decarboxylation of the amino acid tyrosine, exhibiting neuromodulatory properties as well as cardiovascular and immunological effects.",173.64,"60-19-5","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/tyramine-hydrochloride.html","C8H12ClNO","Hydrochloride salt","Tyramine hydrochloride","Cl.NCCC1=CC=C(O)C=C1",1.397,0,2,2]
["E4494","Se-Methylselenocysteine","e6","L3900-40","in 10mM DMSO","Caspase;BCL;IAP","Apoptosis;Proteases/Proteasome","Se-Methylselenocysteine is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.",182.08,"26046-90-2","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/se-methylselenocysteine.html","C4H9NO2Se","free base","Se-Methylselenocysteine","C[Se]CC(N)C(O)=O",-2.442,1,1,3]
["E4518","Oxypurinol","f6","L3900-40","in 10mM DMSO","Endogenous Metabolite; ROS; Xanthine Oxidase","Immunology/Inflammation; Metabolism","Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.",152.11,"2465-59-0","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/oxypurinol.html","C5H4N4O2","Free base","Oxypurinol","O=C1NC(=O)C2=C([NH]N=C2)N1",-0.867,3,3,0]
["E4542","D-chiro-Inositol","g6","L3900-40","in 10mM DMSO","Endogenous Metabolite","Metabolism","D-chiro-Inositol is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity.",180.16,"643-12-9","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/d-chiro-inositol.html","C6H12O6","free base","D-chiro-Inositol","OC1C(O)C(O)C(O)C(O)C1O",-3.065,0,6,0]
["S7830","Coenzyme A","h6","L3900-40","in 10mM DMSO","Endogenous Metabolite","Metabolism","Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.",767.53,"85-61-0","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/coenzyme-a.html","C21H36N7O16P3S","Free base","Coenzyme A","CC(C)(CO[P](O)(=O)O[P](O)(=O)OCC1OC(C(O)C1O[P](O)(O)=O)[N]2C=NC3=C(N)N=CN=C23)C(O)C(=O)NCCC(=O)NCCS",-2.962,10,5,18]
["E4455","Monolaurin","a7","L3900-40","in 10mM DMSO","Bacterial","Microbiology","Monolaurin (1-Monolaurin) is monoacylglycerol which is a bioactive lipid since it can affect the human biological systems. Monolaurin acts as an antibacterial in inhibiting the growth of several pathogenic bacteria, especially gram-positive bacteria.",{"v":274.4,"d":"274.40"},"142-18-7","N/A",">10","N/A","N/A","https://www.selleckchem.com/products/monolaurin.html","C15H30O4","Free base","1-Monolaurin","CCCCCCCCCCCC(=O)OCC(O)CO",3.743,2,2,14]
["E0359","Evocalcet","b7","L3900-40","in 10mM DMSO","CaSR","GPCR & G Protein","Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). Evocalcet (0, 20 and 60 nM) dose-dependently increases cytoplasmic  [Ca2+] concentrations  with an EC50 value of 92.7 nM in hCaR-HEK293 cells.",374.48,"870964-67-3",{"v":75,"d":"75.00"},200.28,"<1","N/A","https://www.selleckchem.com/products/evocalcet.html","C24H26N2O2","free base","KHK7580","CC(NC1CCN(C1)C2=CC=C(CC(O)=O)C=C2)C3=CC=CC4=C3C=CC=C4",1.334,1,1,6]
["E1056","Opnurasib (JDQ-443)","c7","L3900-40","in 10mM DMSO","Ras","Cell cycle","Opnurasib (JDQ-443,NVP-JDQ443) , a potent and selective, orally bioavailable covalent inhibitor of GDP-bound KRAS<sup>G12C</sup> with an IC50 of 0.012 µM for inhibition of c-Raf recruitment.",526.03,"2653994-08-0",{"v":100,"d":"100.00"},{"v":190.1,"d":"190.10"},"<1","N/A","https://www.selleckchem.com/products/jdq443.html","C29H28CIN7O","free base","NVP-JDQ443","C[N]1N=CC2=CC(=CC=C12)C3=N[N](C4CC5(C4)CN(C5)C(=O)C=C)C(=C3C6=C7C=N[NH]C7=CC(=C6Cl)C)C",{"v":4.95,"d":"4.950"},4,1,4]
["E1214","KSQ-4279","d7","L3900-40","in 10mM DMSO","DUB","Ubiquitin","KSQ-4279 (USP1-IN-1) is an orally bioavailable selective inhibitor of the  ubiquitin specific protease 1 (USP1)  with anti-proliferative activity. KSQ-4279 also exhibits synergistic activity in combination with PARP inhibitors.",534.54,"2446480-97-1",{"v":100,"d":"100.00"},187.08,"<1","N/A","https://www.selleckchem.com/products/ksq-4279.html","C27H25F3N8O","free base","USP1-IN-1","COC1=C(C2=NC=C3C=N[N](CC4=CC=C(C=C4)C5=NC(=C[N]5C(C)C)C(F)(F)F)C3=N2)C(=NC=N1)C6CC6",5.203,7,0,8]
["E1297","BGB 15025","e7","L3900-40","in 10mM DMSO","MAP4K","MAPK","BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.",536.64,"2766481-17-6",{"v":100,"d":"100.00"},186.34,"<1","N/A","https://www.selleckchem.com/products/bgb-15025.html","C28H37FN8O2","free base","N/A","CN1CCC(CC1)[N]2C=C(OC3=C(N)N=CC(=N3)C4=CC(=C(C(=C4)C)C(=O)NCCN5CCC(F)C5)C)C=N2",2.757,5,2,8]
["E1310","DPCPX","f7","L3900-40","in 10mM DMSO","Others","Others","DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective adenosine A1 receptor (ADORA1) antagonist, with a Ki of 0.46 nM.",304.39,"102146-07-6",{"v":61,"d":"61.00"},{"v":200.4,"d":"200.40"},"<1","N/A","https://www.selleckchem.com/products/dpcpx.html","C16H24N4O2","free base","PD 116948","CCCN1C(=O)N(CCC)C2=C([NH]C(=N2)C3CCCC3)C1=O",{"v":3.37,"d":"3.370"},3,1,5]
["E1321","Digitonin","g7","L3900-40","in 10mM DMSO","Others","Others","Digitonin, a steroidal saponin and glycoside obtained from <i>Digitalis purpurea</i>, has strong lytic activity on various cell membranes with an IC50 of 15.1 µM on sheep RBC membranes.",1229.31,"11024-24-1",{"v":100,"d":"100.00"},81.35,"<1","N/A","https://www.selleckchem.com/products/digitonin.html","C56H92O29","free base","N/A","CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9O)C8OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C",-5.207,12,17,14]
["E1322","GS-4224","h7","L3900-40","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","GS-4224 (Evixapodlin, PD-1/PD-L1-IN 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. It enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. It exhibits anticancer and antiviral functions.",691.61,"2374856-75-2",{"v":100,"d":"100.00"},144.59,"<1","N/A","https://www.selleckchem.com/products/gs-4224.html","C34H36Cl2N8O4","free base","Evixapodlin, PD-1/PD-L1-IN 7","COC1=C(CNCC2CCC(=O)N2)N=CC(=N1)C3=CC=CC(=C3Cl)C4=C(Cl)C(=CC=C4)C5=NC(=C(CNCC6CCC(=O)N6)N=C5)OC",3.472,8,4,13]
["E1328","TP-1454","a8","L3900-40","in 10mM DMSO","PKM","Metabolism","TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.",462.46,"2490276-04-3",{"v":92,"d":"92.00"},198.94,"<1","N/A","https://www.selleckchem.com/products/tp-1454.html","C19H22F4N4O3S","free base","N/A","NC1=CC=CC(=C1CN(CCC2CC[S](=O)(=O)CC2)C(=O)C3=CC(=N[NH]3)C(F)(F)F)F",2.929,4,2,7]
["E1332","EG-011","b8","L3900-40","in 10mM DMSO","others","Cytoskeletal Signaling","EG-011 is a potent Wiskott-Aldrich syndrome protein (WASP) activator.",482.53,"2377113-41-0",{"v":97,"d":"97.00"},201.02,"<1","N/A","https://www.selleckchem.com/products/eg-011.html","C28H26N4O4","free base","N/A","C=CC(=O)N1CCCC(C1)N2C(=O)N(CC3=CC=C(OC4=CC=CC=C4)C=C3)C5=CC=CN=C5C2=O",3.983,5,0,6]
["E1342","Sebetralstat","c8","L3900-40","in 10mM DMSO","Serine protease","Protease","Sebetralstat(KVD900) is a plasma kallikrien inhibitor.",491.52,"1933514-13-6",{"v":98,"d":"98.00"},199.38,"<1","N/A","https://www.selleckchem.com/products/sebetralstat-kvd900.html","C26H26FN5O4","free base","KVD900","COCC1=N[N](CC2=CC=C(CN3C=CC=CC3=O)C=C2)C=C1C(=O)NCC4=NC=CC(=C4F)OC",1.763,6,1,10]
["E1348","E-7386","d8","L3900-40","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","E-7386 is a selective inhibitor which inhibits interaction between CBP/beta-catenin with IC50 value of 0.0484 μM in HEK293 cells.",725.86,"1799824-08-0",{"v":100,"d":"100.00"},137.77,"<1","N/A","https://www.selleckchem.com/products/e-7386.html","C39H48FN9O4","free base","N/A","CCN1CCN(CC1)C2CN(C2)C3=NC(=CC=C3)CN4CC5N(C(CC6=C(F)C=C(O)C=C6)C4=O)C(=O)CN(CC=C)N5C(=O)NCC7=CC=CC=C7",3.503,4,2,11]
["E1353","AZD1656","e8","L3900-40","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","AZD1656 is a potent, selective and orally active activator of glucokinase. AZD1656 has the potential for type 2 diabetes research.",{"v":478.5,"d":"478.50"},"919783-22-5",{"v":96,"d":"96.00"},200.63,"<1","N/A","https://www.selleckchem.com/products/azd1656.html","C24H26N6O5","free base","N/A","COCC(C)OC1=CC(=CC(=C1)C(=O)NC2=NC=C(C)N=C2)OC3=NC=C(N=C3)C(=O)N4CCC4",0.887,9,1,9]
["E1381","NX-2127","f8","L3900-40","in 10mM DMSO","BTK","Angiogenesis","NX-2127 is a unique, potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells.",719.83,"2416131-46-7",{"v":100,"d":"100.00"},138.92,"<1","N/A","https://www.selleckchem.com/products/nx-2127.html","C39H45N9O5","free base","N/A","NC(=O)C1=NC=C(N=C1NC2=CC=C(C=C2)C3CCN(CC3)CC4CCN(C4)C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)N8CCCCC8",3.536,7,3,9]
["E1382","BI 1015550","g8","L3900-40","in 10mM DMSO","PDE","Metabolism","BI 1015550 is an orally active inhibitor of PDE4B with IC50 of 7.2 nM. It has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).",448.97,"1423719-30-5",{"v":11,"d":"11.00"},{"v":24.5,"d":"24.50"},"<1","N/A","https://www.selleckchem.com/products/bi-1015550.html","C20H25ClN6O2S","free base","N/A","OCC1(CCC1)NC2=C3C(=NC(=N2)N4CCC(CC4)C5=NC=C(Cl)C=N5)CC[S]3=O",1.969,5,2,5]
["E1398","Rilematovir","h8","L3900-40","in 10mM DMSO","RSV","Microbiology","Rilematovir (JNJ-678, JNJ-53718678) is an antiviral agent that inhibits respiratory syncytial virus (RSV) with EC50 of 1.2 nM in HBECs. Rilematovir is also a fusion protein inhibitor.",500.92,"1383450-81-4",{"v":16,"d":"16.00"},31.94,"<1","N/A","https://www.selleckchem.com/products/rilematovir.html","C21H20ClF3N4O3S","free base","JNJ-678, JNJ-53718678","C[S](=O)(=O)CCC[N]1C(=CC2=CC(=CC=C12)Cl)CN3C(=O)N(CC(F)(F)F)C4=CC=NC=C34",3.447,4,0,8]
["E1410","Fluspirilene","a9","L3900-40","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Fluspirilene(R 6218; Redeptin) is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM in cell-free assays. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.",475.57,"1841-19-6",{"v":95,"d":"95.00"},199.76,"<1","N/A","https://www.selleckchem.com/products/fluspirilene.html","C29H31F2N3O","free base","R 6218, Redeptin","FC1=CC=C(C=C1)C(CCCN2CCC3(CC2)N(CNC3=O)C4=CC=CC=C4)C5=CC=C(F)C=C5",5.545,1,1,7]
["E1411","Tuvusertib","b9","L3900-40","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines.",370.32,"1613200-51-3",{"v":12,"d":"12.00"},{"v":32.4,"d":"32.40"},"<1","N/A","https://www.selleckchem.com/products/tuvusertib.html","C16H12F2N8O","free base","M1774, ATR inhibitor 1","C[N]1C=NC=C1C2=C(F)C=NC=C2NC(=O)C3=C4N=CC(=C[N]4N=C3N)F",-0.157,5,2,3]
["E1427","MRT-2359","c9","L3900-40","in 10mM DMSO","E3 Ligase","Ubiquitin","MRT-2359 is a potent degrader of GSPT1. It exhibits anti-tumor activity in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.",495.38,"2803881-11-8",{"v":100,"d":"100.00"},201.87,"<1","N/A","https://www.selleckchem.com/products/mrt-2359.html","C22H17F4N3O6","free base","N/A","FC1=CC=C(OC(F)(F)F)C=C1NC(=O)OCC2=CC=C3CN(C4CCC(=O)NC4=O)C(=O)C3=C2",3.904,6,2,7]
["E2866","Sodium tetradecyl sulfate","d9","L3900-40","in 10mM DMSO","Others","Others","Sodium tetradecyl sulfate, a detergent sclerosant, is widely used agent for esophageal varices and varicose veins.",317.44,"1191-50-0 ",{"v":63,"d":"63.00"},198.46,{"v":63,"d":"63.00"},198.46,"https://www.selleckchem.com/products/sodium-tetradecyl-sulfate.html","C14H30O4S.Na","sodium tetradecyl sulfate","N/A","[Na;v0].CCCCCCCCCCCCCCO[S](O)(=O)=O",5.322,1,0,14]
["E2868","Naloxegol Oxalate","e9","L3900-40","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Naloxegol oxalate (NKTR-118 oxalate) is a μ-opioid-receptor antagonist with a Ki of 33.8 nM. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.",741.82,"1354744-91-4",{"v":100,"d":"100.00"},{"v":134.8,"d":"134.80"},{"v":100,"d":"100.00"},{"v":134.8,"d":"134.80"},"https://www.selleckchem.com/products/naloxegol-oxalate.html","C34H53NO11.C2H2O4","oxalate","N/A","COCCOCCOCCOCCOCCOCCOCCOC1CCC2(O)C3CC4=C5C(=C(O)C=C4)OC1C25CCN3CC=C.OC(=O)C(O)=O",-2.512,11,1,25]
["E2871","Trovafloxacin Mesylate","f9","L3900-40","in 10mM DMSO","TRP Channel","Transmembrane Transporters, Microbiology  & Antibiotic","Trovafloxacin mesylate, a broad-spectrum quinolone antibiotic, is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current.",512.46,"147059-75-4",{"v":100,"d":"100.00"},195.14,"<1","N/A","https://www.selleckchem.com/products/trovafloxacin-mesylate.html","C20H15F3N4O3.CH4O3S","methanesulfonic","N/A","C[S](O)(=O)=O.NC1C2CN(CC12)C3=C(F)C=C4C(=O)C(=CN(C5=C(F)C=C(F)C=C5)C4=N3)C(O)=O",{"v":-0.68,"d":"-0.680"},3,1,3]
["E2872","Clocortolone Pivalate","g9","L3900-40","in 10mM DMSO","Others","Others","Clocortolone pivalate is a mid-potent topical corticosteroid available as a 0.1% emollient cream used in the treatment of corticosteroid-responsive dermatoses.",495.02,"34097-16-0",{"v":33,"d":"33.00"},66.66,"<1","N/A","https://www.selleckchem.com/products/clocortolone-pivalate.html","C27H36CIFO5","free base","N/A","CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1C(=O)COC(=O)C(C)(C)C",4.404,4,1,5]
["E2873","Laropiprant","h9","L3900-40","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","Laropiprant is a potent and selective prostaglandin D2 (DP) receptor antagonist with a Ki value of 0.57 nM.",{"v":435.9,"d":"435.90"},"571170-77-9",{"v":87,"d":"87.00"},199.59,"<1","N/A","https://www.selleckchem.com/products/laropiprant.html","C21H19CIFNO4S","free base","N/A","C[S](=O)(=O)C1=C2[N](CC3=CC=C(Cl)C=C3)C4=C(CCC4CC(O)=O)C2=CC(=C1)F",4.876,3,0,5]
["E2874","Sofpironium bromide","a10","L3900-40","in 10mM DMSO","AChR","Neuronal Signaling","Sofpironium bromide (BBI 4000) is an anticholinergic agent that reduces sweat by inhibiting  M3 muscarinic receptors  in eccrine glands.",{"v":470.4,"d":"470.40"},"1628106-94-4",{"v":94,"d":"94.00"},199.83,{"v":94,"d":"94.00"},199.83,"https://www.selleckchem.com/products/sofpironium-bromide.html","C22H32NO5.Br","bromide","BBI 4000","[Br-].CCOC(=O)C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)C3=CC=CC=C3",-0.905,4,0,9]
["E2875","Levobunolol(l-Bunolol) hydrochloride","b10","L3900-40","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Levobunolol (l-Bunolol) hydrochloride is a potent and nonselective β-adrenergic receptor antagonist with an IC50 of 48 μM.",327.85,"27912-14-7 ",{"v":66,"d":"66.00"},201.31,{"v":66,"d":"66.00"},201.31,"https://www.selleckchem.com/products/levobunolol-l-bunolol-hydrochloride.html","C17H25NO3.ClH","hydrochloride","N/A","Cl.CC(C)(C)NCC(O)COC1=C2CCCC(=O)C2=CC=C1",{"v":2.74,"d":"2.740"},2,2,6]
["E2876","pemafibrate","c10","L3900-40","in 10mM DMSO","PPAR","Metabolism","Pemafibrate(K-877) is a selective agonist of peroxisome proliferator-activated receptor (PPAR) α with an IC50  of 10 µM.",490.55,"848259-27-8",{"v":98,"d":"98.00"},199.78,"<1","N/A","https://www.selleckchem.com/products/pemafibrate.html","C28H30N2O6","free base","K-877","CCC(OC1=CC=CC(=C1)CN(CCCOC2=CC=C(OC)C=C2)C3=NC4=CC=CC=C4O3)C(O)=O",5.794,6,0,13]
["E2878","iothalamate sodium","d10","L3900-40","in 10mM DMSO","Others","Others","Iothalamate sodium is the sodium salt form of iothalamate, an organic iodine compound and a radiographic contrast medium.",{"v":636.9,"d":"636.90"},"1225-20-3",{"v":100,"d":"100.00"},157.01,"<1","N/A","https://www.selleckchem.com/products/iothalamate-sodium.html","C11H9I3N2O4.Na","sodium","N/A","[Na;v0].CNC(=O)C1=C(I)C(=C(I)C(=C1I)NC(C)=O)C(O)=O",1.522,3,2,3]
["E2880","methylnaltrexone bromide","e10","L3900-40","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Methylnaltrexone bromide is an antagonist of µ-opioid receptor that reduces the viability of lung cancer cells by inhibiting Src activation.",436.34,"73232-52-7",{"v":100,"d":"100.00"},229.18,{"v":100,"d":"100.00"},229.18,"https://www.selleckchem.com/products/methylnaltrexone-bromide.html","C21H26NO4.Br","bromide","N/A","[Br-].C[N+]1(CCC23C4OC5=C(O)C=CC(=C25)CC1C3(O)CCC4=O)CC6CC6",-2.116,2,1,2]
["E2886","LY3000328","f10","L3900-40","in 10mM DMSO","Cysteine Protease","Proteases","LY 3000328 (Z-FL-COCHO, Compound 5) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for human Cat S and mouse Cat S, respectively.",484.52,"1373215-15-6",{"v":97,"d":"97.00"},{"v":200.2,"d":"200.20"},"<1","N/A","https://www.selleckchem.com/products/ly3000328.html","C25H29FN4O5","free base","Z-FL-COCHO, Compound 5","CNC(=O)OC1COC2=CC=C(C=C2C1NC(=O)C3=CC=C(F)C=C3)N4CCN(CC4)C5COC5",2.358,5,2,6]
["E2891","Dxd","g10","L3900-40","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Dxd(Exatecan derivative for ADC) is a potent  DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM.",493.48,"1599440-33-1",{"v":8,"d":"8.00"},16.21,"<1","N/A","https://www.selleckchem.com/products/dxd.html","C26H24FN3O6","free base","Exatecan derivative for ADC","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C34)NC(=O)CO)C2=O",1.452,5,2,3]
["E2901","(-)-Isoproterenol hydrochloride","h10","L3900-40","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(-)-Isoproterenol hydrochloride is an agonist of  beta-adrenergic receptor. (-)-Isoproterenol hydrochloride is also used in the treatment of bradycardia; bronchodilator.",247.72,"5984-95-2",{"v":50,"d":"50.00"},201.84,{"v":50,"d":"50.00"},201.84,"https://www.selleckchem.com/products/---isoproterenol-hydrochloride.html","C11H17NO3.CIH","hydrochloride","N/A","Cl.CC(C)NCC(O)C1=CC(=C(O)C=C1)O",1.481,0,4,4]
["E2902","Sodium Pyruvate","a11","L3900-40","in 10mM DMSO","Others","Others","Sodium Pyruvate(Sodium 2-oxopropanoate) is a compound produced in the glycolytic pathway. Sodium Pyruvate is a free radical scavenger that can scavenge ROS.",111.05,"113-24-6",{"v":4,"d":"4.00"},36.02,{"v":22,"d":"22.00"},198.11,"https://www.selleckchem.com/products/sodium-pyruvate.html","C3H4O3.Na","sodium","Sodium 2-oxopropanoate","[Na;v0].CC(=O)C(O)=O",-0.329,2,0,1]
["E2939","Didox","b11","L3900-40","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","Didox (3,4-dihydroxy-benzohydroxamic acid)  is a synthetic ribonucleotide reductase (RR) inhibitor derived from polyhydroxy-substituted benzohydroxamic acid. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells.",169.14,"69839-83-4",{"v":34,"d":"34.00"},201.02,{"v":34,"d":"34.00"},201.02,"https://www.selleckchem.com/products/didox.html","C7H7NO4","free base","3,4-dihydroxy-benzohydroxamic acid","ONC(=O)C1=CC(=C(O)C=C1)O",{"v":0.36,"d":"0.360"},1,3,1]
["E2944","Norepinephrine hydrochloride","c11","L3900-40","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.",205.64,"329-56-6",{"v":41,"d":"41.00"},199.38,{"v":41,"d":"41.00"},199.38,"https://www.selleckchem.com/products/norepinephrine-hydrochloride.html","C8H11NO3.ClH","hydrochloride","Levarterenol; L-Noradrenaline","Cl.NCC(O)C1=CC(=C(O)C=C1)O",0.323,0,4,2]
["E2947","Recilisib","d11","L3900-40","in 10mM DMSO","AKT","PI3K/Akt/mTOR","Recilisib (ON01210, EX-RAD) is a radioprotectant that activates the activity of AKT and PI3K in cells. It has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug.",336.79,"334969-03-8",{"v":67,"d":"67.00"},198.94,"<1","N/A","https://www.selleckchem.com/products/recilisib.html","C16H13ClO4S","chloride","ON 01210, EX-RAD","OC(=O)C1=CC=C(C=C1)\\C=C\\[S](=O)(=O)CC2=CC=C(Cl)C=C2",3.175,3,0,5]
["E2958","Toluidine Blue O","e11","L3900-40","in 10mM DMSO","Others","Others","Toluidine Blue O (Toluidine Blue) is a thiazine dye of the quinone-imine family and is cationic in nature. Toluidine Blue O along with light-emitting diode has been used as a photosensitizer to control in vitro biofilms and to kill gram-negative bacteria. Toluidine Blue has wide applications in vital staining in living tissues and used as a special stain.",305.83,"92-31-9",{"v":61,"d":"61.00"},199.46,{"v":61,"d":"61.00"},199.46,"https://www.selleckchem.com/products/toluidine-blue-o.html","C15H16N3S.Cl","chloride","Toluidine Blue","[Cl-].CN(C)C1=CC2=C(C=C1)N=C3C=C(C)C(=CC3=[S+]2)N",1.131,1,1,1]
["E2964","Norepinephrine tartrate","f11","L3900-40","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Norepinephrine tartrate is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.",319.27,"3414-63-9",{"v":64,"d":"64.00"},200.46,{"v":64,"d":"64.00"},200.46,"https://www.selleckchem.com/products/norepinephrine-tartrate.html","C8H11NO3.C4H6O6","bitartrate","N/A","NCC(O)C1=CC(=C(O)C=C1)O.OC(C(O)C(O)=O)C(O)=O",-4.202,2,6,5]
["E2968","Zinc sulfate heptahydrate","g11","L3900-40","in 10mM DMSO","Others","Others","Zinc sulfate heptahydrate is a hydrate that is the heptahydrate form of zinc sulfate. Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and can also accelerate the rate of healing. It is also used in prepration of zinc tris(thiourea) sulphate (ZTS), a semiorganic nonlinear optic (NLO) material that may be useful in laser fusion experiments and in second-harmonic-generation (SHG) devices.",289.58,"7446-20-0",{"v":36,"d":"36.00"},124.32,{"v":36,"d":"36.00"},124.32,"https://www.selleckchem.com/products/zinc-sulfate-heptahydrate.html","H2O4S.7H2O.Zn","zinc sulfate","N/A","O.[Zn].O[S](O)(=O)=O",-0.815,0,0,0]
["E2970","Gramicidin","h11","L3900-40","in 10mM DMSO","Bacterial","Microbiology","Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) is an antimicrobial peptide that destroys gram-positive bacteria. It inhibits the growth of bacteria by forming pores and channels in the cell wall, which increase its permeability to monovalent cations.",1882.29,"1405-97-6",{"v":100,"d":"100.00"},53.13,"<1","N/A","https://www.selleckchem.com/products/gramicidin.html","N/A","free base","N/A","N/A","N/A","N/A","N/A","N/A"]
["E4010","L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride","a2","L3900-41","in 10mM DMSO","Others","Others","L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride(Melevodopa hydrochloride) is a precursor to L-DOPA. It is an antiparkinsonian agent L-DOPA methyl ester that  elicits antitumor functionality in leukemia and melanoma.",247.68,"1421-65-4",{"v":50,"d":"50.00"},201.87,{"v":50,"d":"50.00"},201.87,"https://www.selleckchem.com/products/l-3,4-dihydroxyphenylalanine-methyl-ester-hydrochloride.html","C10H13NO4.ClH","hydrochloride","Melevodopa hydrochloride","Cl.COC(=O)C(N)CC1=CC(=C(O)C=C1)O",0.997,2,3,4]
["E4013","Melanin","b2","L3900-41","in 10mM DMSO","Others","Others","Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.",318.28,"8049-97-6",{"v":64,"d":"64.00"},201.08,"<1","N/A","https://www.selleckchem.com/products/melanin.html","N/A","free base","N/A","N/A","N/A","N/A","N/A","N/A"]
["E4017","Calcium chloride dihydrate","c2","L3900-41","in 10mM DMSO","Other","Other","Calcium chloride dihydrate is a moisture-resistant, cheap, and commonly available calcium salt. It is used as a calcium supplement in the DMEM (Dulbecco's modified Eagle's medium) for use in cell culture studies and to prepare the synthetic brine solution.",147.01,"10035-04-8",{"v":29,"d":"29.00"},197.27,{"v":29,"d":"29.00"},197.27,"https://www.selleckchem.com/products/calcium-chloride-dihydrate.html","CaCl2.2H2O","calcium chloride dihydrate","N/A","O.Cl[Ca]Cl",0.764,0,0,0]
["S0033","BAR502","d2","L3900-41","in 10mM DMSO","FXR","Metabolism, GPCR & G protein, GPBAR1","BAR502 (Compound 30) is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.",392.62,"1612191-86-2",{"v":79,"d":"79.00"},201.21,"<1","N/A","https://www.selleckchem.com/products/bar502.html","C25H44O3","free base","Compound 30","CCC1C(O)C2C3CCC(C(C)CCO)C3(C)CCC2C4(C)CCC(O)CC14",4.386,0,3,4]
["S1423","Dobutamine HCl","e2","L3900-41","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Dobutamine(Dobutrex) hydrochloride is a selective potent agonist of β1-AR (β-1 adrenergic receptor) and exhibits weak activity at α1-AR and β2-AR. Dobutamine is a sympathomimetic compound that effectively restores blood pressure in hypotensive dogs and human patients by improving myocardial contractility and increasing cardiac output (CO).",337.84,"49745-95-1",{"v":68,"d":"68.00"},201.28,"<1","N/A","https://www.selleckchem.com/products/Dobutamine-hydrochloride.html","C18H23NO3&middot;HCl","hydrochloride","Dobutrex","Cl.CC(CCC1=CC=C(O)C=C1)NCCC2=CC(=C(O)C=C2)O",4.083,0,4,7]
["S7354","Filanesib hydrochloride","f2","L3900-41","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","Filanesib (ARRY-520) hydrochloride is a kinesin spindle protein (KSP) inhibitor that blocks the separation of centrosomes and assembly of spindles in the early stage of cell mitosis, and cell proliferation.",456.94,"1385020-40-5",{"v":91,"d":"91.00"},199.15,{"v":91,"d":"91.00"},199.15,"https://www.selleckchem.com/products/filanesib.html","C20H22F2N4O2S.ClH","hydrochloride","ARRY-520 hydrochloride","Cl.CON(C)C(=O)N1N=C(SC1(CCCN)C2=CC=CC=C2)C3=C(F)C=CC(=C3)F",3.854,3,1,6]
["S8212","Olcegepant","g2","L3900-41","in 10mM DMSO","CGRP Receptor","GPCR & G Protein","Olcegepant (BIBN4096; BIBN4096BS) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with an IC50 of 0.03 nM.",869.65,"204697-65-4",{"v":100,"d":"100.00"},114.99,"<1","N/A","https://www.selleckchem.com/products/olcegepant.html","C38H47Br2N9O5","free base","BIBN4096; BIBN4096BS","NCCCCC(NC(=O)C(CC1=CC(=C(O)C(=C1)Br)Br)NC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C(=O)N5CCN(CC5)C6=CC=NC=C6",2.776,5,5,12]
["S8473","CA-170 (AUPM-170)","h2","L3900-41","in 10mM DMSO","PD-1/PD-L1","Immunology & Inflammation","CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and  VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.",360.32,"1673534-76-3",{"v":72,"d":"72.00"},199.82,"<1","N/A","https://www.selleckchem.com/products/ca-170.html","C12H20N6O7","amine","AUPM-170, PD-1-IN-1","CC(O)C(NC(=O)NC(CC(N)=O)C1=NC(=NO1)C(N)CO)C(O)=O",{"v":-6.28,"d":"-6.280"},6,6,9]
["S8908","AB680","a3","L3900-41","in 10mM DMSO","CD markers","Transmembrane Transporters","AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73.",580.82,"2105904-82-1",{"v":100,"d":"100.00"},172.17,{"v":7,"d":"7.00"},12.05,"https://www.selleckchem.com/products/ab680.html","C20H24ClFN4O9P2","chloride ; hydrogen phosphite","N/A","CC(NC1=C2C=N[N](C3OC(CO[P](O)(=O)C[P](O)(O)=O)C(O)C3O)C2=NC(=C1)Cl)C4=C(F)C=CC=C4",0.964,4,3,9]
["S9633","GS-6207","b3","L3900-41","in 10mM DMSO","HIV Protease","Microbiology","GS-6207 (Lenacapavir) is a HIV-1 capsid inhibitor. It shows anti-HIV activity with an EC50 of 0.1 nM in MT-4 cells.",968.29,"2189684-44-2",{"v":100,"d":"100.00"},103.27,"<1","N/A","https://www.selleckchem.com/products/gs-6207.html","C39H32ClF10N7O5S2","chloride","Lenacapavir","CC(C)(C#CC1=NC(=C(C=C1)C2=C3[N](CC(F)(F)F)N=C(N[S](C)(=O)=O)C3=C(Cl)C=C2)C(CC4=CC(=CC(=C4)F)F)NC(=O)C[N]5N=C(C6=C5C(F)(F)C7CC67)C(F)(F)F)[S](C)(=O)=O",8.496,8,2,15]
["S9865","CB-5339","c3","L3900-41","in 10mM DMSO","p97","Ubiquitin","CB-5339 is a potent p97/Valosin Containing Protein (VCP) inhibitor with an IC50 of 9 nM.",412.49,"1863952-15-1",{"v":100,"d":"100.00"},242.43,"<1","N/A","https://www.selleckchem.com/products/cb-5339.html","C24H24N6O","free base","N/A","CC1=CC2=C(C=CC=C2[N]1C3=NC(=C4CCCN=C4N3)NCC5=CC=CC=C5)C(N)=O",3.683,3,3,5]
["E0109","Fezolinetant","d3","L3900-41","in 10mM DMSO","Neurokinin Receptor","GPCR & G Protein","Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle.",358.39,"1629229-37-3",{"v":72,"d":"72.00"},{"v":200.9,"d":"200.90"},"<1","N/A","https://www.selleckchem.com/products/fezolinetant.html","C₁₆H₁₅FN₆OS","free base","ESN-364","CC1N(CC[N]2C1=NN=C2C3=NC(=NS3)C)C(=O)C4=CC=C(F)C=C4",1.714,5,0,2]
["E1217","PCLX-001 (DDD86481)","e3","L3900-41","in 10mM DMSO","Others","Others","PCLX-001 (DDD86481) is an orally active dual N-myristoyltransferase (NMT) inhibitor. It inhibits NMT1 and NMT2 with IC50 of 5 nM and 8 nM, respectively, in vitro. PCLX-001 inhibits early B-cell receptor (BCR) signalling, which can be used in B-cell malignancy research.",537.51,"1215011-08-7",{"v":13,"d":"13.00"},24.19,"<1","N/A","https://www.selleckchem.com/products/pclx-001-ddd86481.html","C24H30Cl2N6O2S","free base","DDD86481","CC(C)CC1=N[N](C)C(=C1N[S](=O)(=O)C2=C(Cl)C=C(C=C2Cl)C3=CC=NC(=C3)N4CCNCC4)C",4.589,4,2,7]
["E1431","Lirafugratinib","f3","L3900-41","in 10mM DMSO","FGFR inhibitor","Angiogenesis","Lirafugratinib (RLY-4008) is an orally active and selective inhibitor of FGFR2.",509.54,"2549174-42-5",{"v":20,"d":"20.00"},39.25,"<1","N/A","https://www.selleckchem.com/products/lirafugratinib.html","C28H24FN7O2","free base","RLY-4008","C[N]1C2=NC=NC(=C2C(=C1C3=CC=C(NC(=O)C(C)=C)C=C3)C4=CC(=C(OC5=NC=CC(=N5)C)C=C4)F)N",4.925,6,2,6]
["E1435","Tinengotinib","g3","L3900-41","in 10mM DMSO","Aurora Kinase","Cell Cycle","Tinengotinib (TT-00420) is a novel multiple kinase inhibitor that strongly inhibits Aurora A/B with IC50 values of 1.2/3.3 nM respectively. It also exhibits potent inhibitory activity on FGFR1/2/3, VEGFR1, JAK1/2, and CSF1R and can be used to treat several prominent signaling pathways in triple-negative breast cancer(TNBC).",394.86,"2230490-29-4",{"v":79,"d":"79.00"},200.07,"<1","N/A","https://www.selleckchem.com/products/tinengotinib.html","C20H19ClN6O","free base","TT-00420","CC1=C2N=C(C3=C(Cl)C=CC=C3)C4=CN=C(C=C4NC2=N[NH]1)N5CCOCC5",3.822,4,2,2]
["E1478","BDTX-1535","h3","L3900-41","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","BDTX-1535 (EGFR-IN-76) is an orally available, highly potent, selective, and irreversible EGFR inhibitor that can penetrate the blood-brain barrier, with the potential to treat Glioblastoma or Non-Small Cell Lung Cancer.",561.05,"2607829-38-7",{"v":100,"d":"100.00"},178.24,"<1","N/A","https://www.selleckchem.com/products/bdtx-1535.html","C30H30ClFN6O2","free base","EGFR-IN-76","CN1CC2CC2(C1)C#CC3=CC4=C(C=C3NC(=O)\\C=C\\CN5CCOCC5)C(=NC=N4)NC6=C(F)C(=CC=C6)Cl",{"v":4.5,"d":"4.500"},4,2,8]
["E1495","PF-07220060 (CDK4/6-IN-6)","a4","L3900-41","in 10mM DMSO","CDK","Cell Cycle","PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.",463.93,"2380321-51-5",{"v":93,"d":"93.00"},200.46,"<1","N/A","https://www.selleckchem.com/products/pf-07220060.html","C22H27ClFN5O3","free base","CDK4/6-IN-6","CC(C)[N]1C2=CC(=CC(=C2N=C1C(C)(C)O)F)C3=NC(=NC=C3Cl)NC4CCOCC4O",3.298,4,2,5]
["E1512","M3541","b4","L3900-41","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","M3541 is a potent and selective inhibitor of ATM kinase activity with an IC50 value of 0.25 nM in cell-free assays. M3541 suppresses double-strand breaks (DSB) repair, clonogenic cancer cell growth and potentiates antitumor activity of ionizing radiation in cancer cell lines.",428.42,"1360628-91-6",{"v":11,"d":"11.00"},25.68,"<1","N/A","https://www.selleckchem.com/products/m3541.html","C23H17FN6O2","free base","N/A","COC1=C(C=C2C(=C1)N=CC3=C2N(C(=O)N3C)C4=C(F)C=C(C=C4)C#N)C5=C[N](C)N=C5",3.103,4,0,3]
["E1573","ARV-766","c4","L3900-41","in 10mM DMSO","PROTAC","Others","ARV-766 (Luxdegalutamide) is an orally active and potent degrader of proteolysis targeting chimera (PROTAC) protein. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.",807.95,"2750830-09-0",{"v":100,"d":"100.00"},123.77,"<1","N/A","https://www.selleckchem.com/products/arv-766.html","C45H54FN7O6","free base","Luxdegalutamide","COC1=C(C=CC(=C1)OC2C(C)(C)C(NC(=O)C3=CC=C(C=C3)N4CCC(CC4)CN5CCN(CC5)C6=CC(=C(C=C6)C(=O)NC7CCC(=O)NC7=O)F)C2(C)C)C#N",5.365,6,3,11]
["E1578","garsorasib (D-1553 )","d4","L3900-41","in 10mM DMSO","Ras","GPCR & G Protein","Garsorasib (D-1553 ) is a potent and selective oral KRAS<sup>G12C</sup> inhibitor with antitumor activity. It has the potential to treat KRAS G12C-mutated non-small cell lung cancer (NSCLC).",598.65,"2559761-14-5",{"v":100,"d":"100.00"},167.04,"<1","N/A","https://www.selleckchem.com/products/d-1553.html","C32H32F2N8O2","free base","N/A","CC1CN(C(C)CN1C(=O)C=C)C2=NC(=O)N(C3=NC(=C(F)C=C23)C4=C(F)C=CC=C4N)C5=C(N=CN=C5C6CC6)C7CC7",4.785,6,1,6]
["E1596","AOH1996","e4","L3900-41","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","AOH1996 is an orally active small-molecule PCNA inhibitor with potential anti-tumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.",426.46,"2089314-64-5",{"v":85,"d":"85.00"},199.32,"<1","N/A","https://www.selleckchem.com/products/aoh1996.html","C26H22N2O4","free base","N/A","COC1=CC=CC(=C1)OC2=C(NC(=O)CNC(=O)C3=CC=CC4=C3C=CC=C4)C=CC=C2",4.126,4,2,7]
["E1602","Lotiglipron","f4","L3900-41","in 10mM DMSO","Glucagon Receptor","GPCR & G Protein","Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. It reduces glucose and body weight, and has the potential to be used in Type 2 diabetes mellitus (T2DM) research.",575.06,"2401892-75-7",{"v":100,"d":"100.00"},173.89,"<1","N/A","https://www.selleckchem.com/products/lotiglipron.html","C31H31ClN4O5","free base","PF-07081532","CC1(OC2=CC=CC(=C2O1)C3CCN(CC3)CC4=NC5=CC=C(C=C5[N]4CC6CCO6)C(O)=O)C7=CC=C(Cl)C=N7",1.843,6,0,7]
["E1649","Exarafenib","g4","L3900-41","in 10mM DMSO","Raf","MAPK","Exarafenib(KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.",521.58,"2639957-39-2",{"v":100,"d":"100.00"},191.73,"<1","N/A","https://www.selleckchem.com/products/exarafenib.html","C26H34F3N5O3","free base","KIN-002787, KIN-2787, RAF/KIN_2787","CC(CO)NC1=NC(=CC(=C1)C2=CC(=CC=C2C)NC(=O)N3CCC(C3)CC(F)(F)F)N4CCOCC4",4.073,3,3,8]
["E1650","Opevesostat (ODM208)","h4","L3900-41","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Opevesostat (ODM208) is the first-in-class, selective, nonsteroidal, oral CYP11A1 inhibitor. ODM208 exhibits a rapid, complete, durable, and reversible inhibition of the steroid hormone biosynthesis in an adrenocortical carcinoma cell model in vitro, in adult noncastrated male mice and dogs, and in patients with CRPC.",418.51,"2231294-96-3",{"v":7,"d":"7.00"},16.73,"<1","N/A","https://www.selleckchem.com/products/odm208.html","C21H26N2O5S","free base","N/A","C[S](=O)(=O)N1CCC(CC1)COC2=COC(=CC2=O)CN3CC4=CC=CC=C4C3",0.869,5,0,6]
["E1657","Gamcemetinib (CC-99677)","a5","L3900-41","in 10mM DMSO","MAPKAPK2","MAPK","Gamcemetinib (CC-99677,BMS-986371) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) (MAPKAPK2 (MK2)) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM).",469.95,"1887069-10-4",{"v":94,"d":"94.00"},200.02,"<1","N/A","https://www.selleckchem.com/products/cc-99677.html","C22H20ClN5O3S","free base","BMS-986371","CCOCC1=CN=C(Cl)N=C1OC2=CC=C3C(=N2)C=CC4=C3C5=C(S4)C(=O)NC(C)CN5",{"v":4.25,"d":"4.250"},6,2,5]
["E1658","PRT543","b5","L3900-41","in 10mM DMSO","PRMT","Epigenetics","PRT543 is a  potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM.",376.79,"1989620-03-2",{"v":75,"d":"75.00"},199.05,"<1","N/A","https://www.selleckchem.com/products/prt543.html","C17H17ClN4O4","free base","N/A","NC1=C2C=C[N](C3OC(C(O)C3O)C(O)C4=CC=C(Cl)C=C4)C2=NC=N1",1.174,3,4,3]
["E1667","LY2880070","c5","L3900-41","in 10mM DMSO","Chk","Cell Cycle","LY2880070 is an orally active inhibitor of CHK1. LY2880070 can be used as an anticancer agent and shows promise in preclinical models of pancreatic ductal adenocarcinoma (PDAC) when used in combination with DNA-damaging agents.",381.43,"1375637-35-6",{"v":76,"d":"76.00"},199.25,"<1","N/A","https://www.selleckchem.com/products/ly2880070.html","C19H23N7O2","free base","N/A","COC1=C(C=CC(=N1)C)C2=CC(=N[NH]2)NC3=NC(=CN=C3)OC4CCCNC4",{"v":2.68,"d":"2.680"},6,3,6]
["E1692","BAY 2965501","d5","L3900-41","in 10mM DMSO","Others","Metabolism","BAY 2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level, and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill.",414.46,"2732902-08-6",{"v":83,"d":"83.00"},200.26,"<1","N/A","https://www.selleckchem.com/products/bay-2965501.html","C20H19FN4O3S","free base","N/A","COC1=CC=C(C=C1)C(=O)C2=C(N)N=C(S2)N(C(C)C(N)=O)C3=CC=C(F)C=C3",3.598,4,2,7]
["E1709","Fialuridine","e5","L3900-41","in 10mM DMSO","CMV","Microbiology","Fialuridine(FIAU, DRG-0098, NSC 678514) is a nucleoside analog with antiviral activity. It blocks DNAsynthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex.",372.09,"69123-98-4",{"v":74,"d":"74.00"},198.88,"<1","N/A","https://www.selleckchem.com/products/fialuridine.html","C9H10FIN2O5","free base","FIAU; DRG-0098; NSC 678514","OCC1OC(C(F)C1O)N2C=C(I)C(=O)NC2=O",-1.228,3,3,2]
["E1727","Pimicotinib","f5","L3900-41","in 10mM DMSO","CSF-1R","Protein Tyrosine Kinase","Pimicotinib (ABSK021) is an orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R). It enhances antitumor T-cell immune responses and inhibits the proliferation of tumor cells having potential immunomodulatory and antineoplastic activities.",420.47,"2253123-16-7",{"v":84,"d":"84.00"},199.78,"<1","N/A","https://www.selleckchem.com/products/pimicotinib.html","C22H24N6O3","free base","ABSK021","C[N]1C=C(C=N1)C2=CC(=CC=N2)OC3=C(C)N=C(NC(=O)N4CCC(C)(C)C4=O)C=C3",2.748,6,1,4]
["E1732","Itacnosertib (TP-0184)","g5","L3900-41","in 10mM DMSO","ALK","Protein Tyrosine Kinase","Itacnosertib (TP-0184) is a small-molecule inhibitor of the BMP type 1 receptor ALK2 (also known as ACVR1). Itacnosertib reduces hepcidin induction and elevated serum iron levels in turpentine and lung cancer mouse models of ACD.",468.55,"1628870-27-8",{"v":15,"d":"15.00"},32.01,"<1","N/A","https://www.selleckchem.com/products/itacnosertib.html","C26H28N8O","free base","TP-0184","COC1=C(C=CC(=C1)NC2=NC=CC(=N2)NC3=C(N=CC=C3)C4=CC=CC=N4)N5CCN(C)CC5",4.388,5,2,7]
["E1743","VX-561(CTP-656, Deutivacaftor)","h5","L3900-41","in 10mM DMSO","CFTR","Transmembrane Transporters","VX-561 (Ivacaftor-D9, CTP-656, Deutivacaftor), a deuterated ivacaftor analog, is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE cells.",401.55,"1413431-07-8",{"v":80,"d":"80.00"},199.23,"<1","N/A","https://www.selleckchem.com/products/vx-561.html","C24H19D9N2O3","free base","Ivacaftor-D9, CTP-656, Deutivacaftor","C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C1=CC(=C(NC(=O)C2=CNC3=CC=CC=C3C2=O)C=C1O)C(C)(C)C)([2H])([2H])[2H]",4.516,2,3,7]
["E1775","2,4-Thiazolidinedione","a6","L3900-41","in 10mM DMSO","PPAR","Metabolism","2,4-Thiazolidinedione (Thiazolidinedione), an insulin sensitizer, is a specific agonist of peroxisome proliferator-activated receptor (PPAR)γ. Thiazolidinedione treatment corrects impaired muscle insulin action in vivo.",117.13,"2295-31-0",{"v":23,"d":"23.00"},196.36,{"v":23,"d":"23.00"},196.36,"https://www.selleckchem.com/products/2,4-thiazolidinedione.html","C3H3NO2S","free base","Thiazolidinedione","O=C1CSC(=O)N1",0.045,2,1,0]
["E2363","Etrasimod(APD334)","b6","L3900-41","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.",457.49,"1206123-37-6",{"v":92,"d":"92.00"},{"v":201.1,"d":"201.10"},"<1","N/A","https://www.selleckchem.com/products/apd334.html","C26H26F3NO3","free base","APD334","OC(=O)CC1CCC2=C1[NH]C3=CC=C(OCC4=CC(=C(C=C4)C5CCCC5)C(F)(F)F)C=C23",6.935,2,1,7]
["E2668","Cirtuvivint","c6","L3900-41","in 10mM DMSO","CDK","Cell Cycle","Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimized for Wnt pathway inhibition. Cirtuvivint inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity. Cirtuvivint can be used for solid tumor research.",{"v":427.5,"d":"427.50"},"2143917-62-6",{"v":22,"d":"22.00"},51.46,"<1","N/A","https://www.selleckchem.com/products/cirtuvivint.html","C24H25N7O","free base","SM08502","CN1CCN(CC1)C2=CC(=CC=N2)C(=O)NC3=CC4=C(C=CC(=C4)C5=C[N](C)N=C5)C=N3",2.587,4,1,4]
["E2869","Propiolactone","d6","L3900-41","in 10mM DMSO","Others","Others","Propiolactone(β-Propiolactone), a sterilizing and sporicidal agent, is used to sterilize blood plasma, vaccines, tissue grafts, surgical instruments and enzymes.",72.06,"57-57-8",{"v":100,"d":"100.00"},1387.73,"<1","N/A","https://www.selleckchem.com/products/propiolactone.html","C3H4O2","free base","N/A","O=C1CCO1",-0.045,2,0,0]
["E2881","Cefotetan disodium salt","e6","L3900-41","in 10mM DMSO","Others","Microbiology","Cefotetan disodium salt is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. It showed <i>in vitro</i> efficacy against ESBL-producing <i>E.coli</i> bloodstream isolates with MIC50 of 0.25 mg/L.",{"v":621.6,"d":"621.60"},"74356-00-6 ",{"v":100,"d":"100.00"},160.88,"<1","N/A","https://www.selleckchem.com/products/cefotetan-disodium-salt.html","C17H17N7O8S4.2Na","Disodium","N/A","[Na;v0].COC1(NC(=O)[CH]2S[C](S2)=[C](C(N)=O)C(O)=O)C3SCC(=C(N3C1=O)C(O)=O)CSC4=NN=N[N]4C",-0.383,9,2,9]
["E2985","Capadenoson","f6","L3900-41","in 10mM DMSO","Adenosine Receptor","GPCR & G Protein","Capadenoson (BAY 68-4986) is an orally bioavailable, non-nucleoside partial adenosine A1 receptor agonist that exhibits an anti-ischemic effect.",520.03,"544417-40-5",{"v":50,"d":"50.00"},96.15,"<1","N/A","https://www.selleckchem.com/products/capadenoson.html","C25H18ClN5O2S2","free base","BAY 68-4986","NC1=NC(=C(C#N)C(=C1C#N)C2=CC=C(OCCO)C=C2)SCC3=CSC(=N3)C4=CC=C(Cl)C=C4",5.116,3,2,8]
["E4443","S-Nitrosoglutathione","g6","L3900-41","in 10mM DMSO","Others","Others","S-nitrosoglutathione (GSNO, RVC-588, S-Nitroso-L-glutathione,Nitrosoglutathione) is an amino acid and nitric oxide donor that, under physiological conditions, spontaneously releases nitric oxide. S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF-κB activation. It induces apoptosis in T cells in low concentrations (< 0.6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM).",336.32,"57564-91-7",{"v":67,"d":"67.00"},199.22,{"v":17,"d":"17.00"},50.55,"https://www.selleckchem.com/products/s-nitrosoglutathione.html","C10H16N4O7S","free base","GSNO , RVC-588 , S-Nitroso-L-glutathione , Nitrosoglutathione","NC(CCC(=O)NC(CSN=O)C(=O)NCC(O)=O)C(O)=O",-4.295,5,3,11]
["E4466","Saquinavir Mesylate","h6","L3900-41","in 10mM DMSO","HIV Protease","Proteases","Saquinavir mesylate (Ro 31-8959/003) is a potent inhibitor of HIV Protease used in antiretroviral therapy. It blocks proteolysis of polyproteins containing either wild-type or single-chain dimer retroviral proteinase (PR).",766.95,"149845-06-7",{"v":50,"d":"50.00"},65.19,"<1","N/A","https://www.selleckchem.com/products/saquinavir-mesylate.html","C38H50N6O5.CH4O3S","mesylate salt","Ro 31-8959/003","CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(O)C(CC3=CC=CC=C3)NC(=O)C(CC(N)=O)NC(=O)C4=NC5=C(C=CC=C5)C=C4.C[S](O)(=O)=O",3.253,5,5,13]
["E4467","Temozolomide Acid","a7","L3900-41","in 10mM DMSO","Others","Others","Temozolomide acid is a carboxylic acid derivative of Temozolomide. It has an anticancer activity by causing breaks in DNA double strand, cell cycle arrest, and eventually cell death.",195.14,"113942-30-6",{"v":39,"d":"39.00"},199.86,"<1","N/A","https://www.selleckchem.com/products/temozolomide-acid.html","C6H5N5O3","free base","N/A","CN1N=NC2=C(N=C[N]2C1=O)C(O)=O",0.679,5,0,1]
["E4472","Clavulanic acid","b7","L3900-41","in 10mM DMSO","β-lactamase","Microbiology","Clavulanic acid is a naturally occurring, powerful bacterial β-lactamase inhibitor. The beta-lactam ring found in clavulanic acid binds to the active site of beta-lactamase, resulting in enzyme inactivation and enhancing the antibacterial activity of beta-lactam antibiotics like amoxicillin.",199.16,"58001-44-8",{"v":40,"d":"40.00"},200.84,{"v":40,"d":"40.00"},200.84,"https://www.selleckchem.com/products/clavulanic-acid.html","C8H9NO5","free base","N/A","OC\\C=C\\1OC2CC(=O)N2C1C(O)=O",-1.235,3,1,2]
["E4474","Infigratinib Phosphate","c7","L3900-41","in 10mM DMSO","FGFR","Angiogenesis","Infigratinib Phosphate (NVP-BGJ398 phosphate) is the phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human  fibroblast growth factor receptors (FGFRs)  with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for  FGFR1, FGFR2, FGFR3, and FGFR4 respectively. It also has potential antiangiogenic, antineoplastic and antitumor activities.",658.47,"1310746-10-1",{"v":100,"d":"100.00"},151.87,"<1","N/A","https://www.selleckchem.com/products/infigratinib-phosphate.html","C26H31Cl2N7O3.H3O4P","Phosphate","NVP-BGJ398 phosphate","CCN1CCN(CC1)C2=CC=C(NC3=CC(=NC=N3)N(C)C(=O)NC4=C(Cl)C(=CC(=C4Cl)OC)OC)C=C2.O[P](O)(O)=O",4.874,5,2,8]
["E4477","Lumateperone","d7","L3900-41","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Lumateperone (ITI-007) is an antagonist of 5-HT2A receptor with Ki of 0.54 nM. It has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.",{"v":393.5,"d":"393.50"},"313368-91-1",{"v":79,"d":"79.00"},200.76,"<1","N/A","https://www.selleckchem.com/products/lumateperone.html","C24H28FN3O","free base","ITI-007","CN1CCN2C3CCN(CCCC(=O)C4=CC=C(F)C=C4)CC3C5=CC=CC1=C25",3.765,1,0,5]
["E4478","Acetrizoic acid","e7","L3900-41","in 10mM DMSO","Others","Others","Acetrizoic acid is a first monomeric, water-soluble, iodinated ionic compound used as an X-ray contrast agent having nephrotropic property that can be intravenously administered for clinical applications.",556.86,"85-36-9",{"v":100,"d":"100.00"},179.58,"<1","N/A","https://www.selleckchem.com/products/acetrizoic-acid.html","C9H6I3NO3","free base","N/A","CC(=O)NC1=C(I)C(=C(I)C=C1I)C(O)=O",2.314,2,1,2]
["S3575","Zandelisib","f7","L3900-41","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Zandelisib(ME-401; PWT-143) is an orally bioavailable inhibitor of the phosphatidylinositide 3-kinase (PI3K). It selectively inhibits the delta isoform of PI3K (p110δ)  and prevents the activation of the PI3K/AKT signaling pathway with an IC50 of 3.5 nM. It functions as an antineoplastic agent.",576.68,"1401436-95-0",{"v":13,"d":"13.00"},22.54,"<1","N/A","https://www.selleckchem.com/products/zandelisib.html","C31H38F2N8O","free base","ME-401; PWT-143","CN1CCC(CC1)C2=C(CC(C)(C)NC3=NC(=NC(=N3)[N]4C(=NC5=CC=CC=C45)C(F)F)N6CCOCC6)C=CC=C2",6.503,5,1,8]
["S7236","Cariprazine hydrochloride","g7","L3900-41","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors, with preferential binding to the D3 receptor. It exhibits high selectivity and affinity to dopamine D3 (Ki = 0.085 nM) and D2 (Ki = 0.49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki = 2.6 nM).",463.87,"1083076-69-0",{"v":12,"d":"12.00"},25.87,"<1","N/A","https://www.selleckchem.com/products/cariprazine-rgh-188.html","C21H32Cl2N4O.HCl","hydrochloride","RGH188 hydrochloride","Cl.CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(Cl)C(=CC=C3)Cl",4.934,1,1,5]
["S8395","INDY","h7","L3900-41","in 10mM DMSO","DYRK","Cell Cycle","INDY, a benzothiazole derivative is a potent and ATP-competitive inhibitor of Dyrk1A and Dyrk1B with an IC50 value of 0.24 μM and Ki value of 0.18 μM, respectively. INDY diminishes the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells.",{"v":235.3,"d":"235.30"},"1169755-45-6",{"v":47,"d":"47.00"},199.75,"<1","N/A","https://www.selleckchem.com/products/indy.html","C12H13NO2S","free base","N/A","CCN1/C(SC2=CC=C(O)C=C12)=C/C(C)=O",2.799,1,1,2]
["S8545","TEN-010 (RG6146,Ro-6870810,(S)-JQ-35)","a8","L3900-41","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","TEN-010 (RG6146, Ro-6870810,(S)-JQ-35) is an inhibitor of the Bromodomain and Extra-Terminal(BET) family bromodomain-containing proteins with potential antineoplastic activity.",540.13,"1349719-98-7",{"v":33,"d":"33.00"},{"v":61.1,"d":"61.10"},{"v":100,"d":"100.00"},185.14,"https://www.selleckchem.com/products/ten-010.html","C27H34ClN7OS","chloride","RG6146, Ro-6870810, (S)-JQ-35","CN1CCN(CCCNC(=O)CC2N=C(C3=CC=C(Cl)C=C3)C4=C(SC(=C4C)C)[N]5C(=NN=C25)C)CC1",3.533,4,1,7]
["S9741","TAS-119","b8","L3900-41","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAS-119 is a potent, selective, and orally active inhibitor of Aurora A, including Aurora B with an IC50 of 1.0 nM and 95 nM, respectively. It exhibits antitumor activities.",506.36,"1453099-83-6",{"v":100,"d":"100.00"},197.49,"<1","N/A","https://www.selleckchem.com/products/tas-119.html","C23H22Cl2FN5O3","Chloride","N/A","CC1=CC(=N[NH]1)NC2=NC(=CC=C2F)CC3(CCN(CC3)C(=O)C4=C(Cl)C(=CC=C4)Cl)C(O)=O",4.859,4,2,6]
["S9969","RMC-4630","c8","L3900-41","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","RMC-4630 (SSE15206) is an inhibitor of microtubule polymerization with a GI50 of 197 nM in HCT116 cells. It can overcome multidrug resistance and cause aberrant mitosis, resulting in G2/M arrest due to incomplete spindle formation in cancer cells.",450.99,"2172652-48-9",{"v":45,"d":"45.00"},99.78,"<1","N/A","https://www.selleckchem.com/products/rmc-4630.html","C20H27ClN6O2S","Chloride","SSE15206","CC1OCC2(CCN(CC2)C3=NC(=C(SC4=CC=NC(=C4Cl)N)N=C3CO)C)C1N",1.624,4,3,4]
["E0608","Pyrilutamide(KX-826)","d8","L3900-41","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Pyrilutamide (KX-826) is an antagonist of androgen receptor (AR) and a potential first-in-class topical drug for the treatment of androgenetic alopecia (AGA) and acne vulgaris.",482.43,"1272719-00-2",{"v":96,"d":"96.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/kx-826.html","C21H15F5N4O2S","Free Base","KX-826","CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=C(F)C(=C(C=C3)C#N)C(F)(F)F",{"v":5.16,"d":"5.160"},2,1,4]
["E1203","Sirpiglenastat","e8","L3900-41","in 10mM DMSO","Glutaminase","Proteases","Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. It has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response with immunomodulatory and antineoplastic activities.",441.48,"2079939-05-0",{"v":88,"d":"88.00"},199.33,"<1","N/A","https://www.selleckchem.com/products/sirpiglenastat.html","C22H27N5O5","free base","DRP-104","CC(C)OC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(C)=O",1.729,5,3,12]
["E1280","Ubrogepant","f8","L3900-41","in 10mM DMSO","CGRP Receptor","GPCR & G Protein","Ubrogepant (MK-1602) is an antagonist of human calcitonin gene-related peptide receptor (CGRP). It potently blocks human α–CGRP–stimulated cAMP responses with an IC50 of 0.081 nM in human CGRP receptor-expressing HEK293 cells.",549.54,"1374248-77-7",{"v":100,"d":"100.00"},181.97,"<1","N/A","https://www.selleckchem.com/products/ubrogepant.html","C29H26F3N5O3","free base","MK-1602","CC1C(CC(NC(=O)C2=CN=C3CC4(CC3=C2)C(=O)NC5=NC=CC=C45)C(=O)N1CC(F)(F)F)C6=CC=CC=C6",2.897,5,2,5]
["E1318","Mavorixafor","g8","L3900-41","in 10mM DMSO","CXCR","GPCR & G Protein","Mavorixafor (AMD-070) is a potent, selective CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.",349.47,"558447-26-0",{"v":70,"d":"70.00"},{"v":200.3,"d":"200.30"},"<1","N/A","https://www.selleckchem.com/products/mavorixafor.html","C21H27N5","free base","AMD-070","NCCCCN(CC1=NC2=CC=CC=C2[NH]1)C3CCCC4=CC=CN=C34",3.196,2,2,7]
["E1433","LY3537982 (KRAS G12C inhibitor 19)","h8","L3900-41","in 10mM DMSO","Ras","GPCR & G Protein","LY3537982 (KRAS G12C inhibitor 19) is a highly selective and potent inhibitor of the  KRAS-G12C protein. LY3537982 selectively inhibits the growth of KRAS G12C mutant cells H23 G12C, H358 G12C, and H2122 G12C with IC50s of 1.04 nM, 1.16 nM, and 11.38 nM, respectively.",528.96,"2649788-46-3",{"v":100,"d":"100.00"},189.05,"<1","N/A","https://www.selleckchem.com/products/ly3537982.html","C25H19ClF2N4O3S","free base","N/A","NC1=C(C#N)C2=C(C=CC(=C2S1)F)C3=C(F)C=C4C(=O)N5CCN(CC5CCOC4=C3Cl)C(=O)C=C",3.764,3,1,2]
["E1445","Palovarotene","a9","L3900-41","in 10mM DMSO","Retinoid Receptor","Metabolism","Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.",414.54,"410528-02-8",{"v":83,"d":"83.00"},200.22,"<1","N/A","https://www.selleckchem.com/products/palovarotene.html","C27H30N2O2","free base","R 667, Ro 3300074","CC1(C)CCC(C)(C)C2=CC(=C(C[N]3C=CC=N3)C=C12)\\C=C\\C4=CC=C(C=C4)C(O)=O",6.108,2,0,5]
["E1477","EP4-IN-1","b9","L3900-41","in 10mM DMSO","Prostaglandin Receptor","GPCR & G Protein","EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor. It exhibits prospects in tumor immunity and anti-inflammatory analgesia research.",440.49,"2455480-28-9",{"v":88,"d":"88.00"},199.78,"<1","N/A","https://www.selleckchem.com/products/kf-0210.html","C27H24N2O4","free base","N/A","OC(=O)C12CC(C1)(C2)C3(CC3)NC(=O)C4=C5[N](CC6=CC7=CC=CC=C7O6)C=CC5=CC=C4",4.172,3,1,6]
["E1483","IK-930","c9","L3900-41","in 10mM DMSO","TEAD","Hippo","IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.",424.44,"2563892-44-2",{"v":85,"d":"85.00"},200.26,"<1","N/A","https://www.selleckchem.com/products/ik-930.html","C19H19F3N4O2S","free base","N/A","CN[S](=O)(=O)C1=CC(=C(NCC2=CC=C(C=C2)C(F)(F)F)C=C1)C3=C[N](C)C=N3",3.115,3,2,7]
["E1486","Zamaporvint (RXC004)","d9","L3900-41","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. It targets membrane-bound o-acyltransferase Porcupine and inhibits Wnt ligand palmitoylation, secretion, and pathway activation. RXC004 exhibits potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines and possesses multiple antitumor mechanisms.",439.39,"1900754-56-4",{"v":88,"d":"88.00"},200.28,"<1","N/A","https://www.selleckchem.com/products/rxc004.html","C21H16F3N7O","free base","N/A","CC1=C(N=C[N]1CC(=O)NC2=CC=C(C=N2)C3=NC=CN=C3)C4=CC=NC(=C4)C(F)(F)F",1.906,6,1,6]
["E1497","Tulmimetostat","e9","L3900-41","in 10mM DMSO","EZH1/2","Epigenetics","Tulmimetostat (CPI-0209) is an orally bioavailable and selective inhibitor of EZH2 that has therapeutic potential for androgen receptor-dependent prostate cancer.",562.12,"2567686-02-4",{"v":100,"d":"100.00"},{"v":177.9,"d":"177.90"},"<1","N/A","https://www.selleckchem.com/products/tulmimetostat.html","C28H36ClN3O5S","Chloride","CPI-0209","COC1CN(C1)C2CCC(CC2)C3(C)OC4=C(Cl)C=C(C(=O)NCC5=C(SC)C=C(C)NC5=O)C(=C4O3)C",{"v":3.48,"d":"3.480"},5,2,7]
["E1509","Bezuclastinib","f9","L3900-41","in 10mM DMSO","c-Kit","Protein Tyrosine Kinase","Bezuclastinib(CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V with an IC50 value of <1 μM. Bezuclastinib is also an inhibitor of tyrosine kinase.",331.37,"1616385-51-3",{"v":33,"d":"33.00"},99.59,"<1","N/A","https://www.selleckchem.com/products/bezuclastinib.html","C19H17N5O","free base","CGT9486, PLX 9486","CC1=C(C)C(=N[NH]1)C(=O)NC2=CN=C3[NH]C(=CC3=C2)C4=CC=CC=C4",{"v":3.27,"d":"3.270"},3,3,3]
["E1517","ZEN-3694","g9","L3900-41","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ZEN-3694 is an orally bioavailable  bromodomain extraterminal inhibitor (BETi)  that leads to down-regulation of expression of AR-signaling in metastatic castrationresistant prostate cancer (mCRPC) models.",333.39,"1643947-30-1",{"v":67,"d":"67.00"},200.97,"<1","N/A","https://www.selleckchem.com/products/zen-3694.html","C19H19N5O","free base","N/A","CNC1=NC2=NC=C(C=C2[N]1CC3=CC=CC=C3)C4=C(C)ON=C4C",{"v":2.93,"d":"2.930"},4,1,4]
["P1127","Pasireotide","h9","L3900-41","in 10mM DMSO","SSTR","Endocrinology & Hormones","Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor (SSTR) subtypes sst1,2,3 and sst5. It potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing’s disease.",1047.21,"396091-73-9",{"v":100,"d":"100.00"},95.49,"<1","N/A","https://www.selleckchem.com/products/pasireotide.html","C58H66N10O9","free base","SOM230","NCCCCC1NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(CC5=CC=CC=C5)NC(=O)C(CC6=CC=C(OCC7=CC=CC=C7)C=C6)NC1=O)OC(=O)NCCN)C8=CC=CC=C8",3.721,9,9,18]
["S4684","Sildenafil","a10","L3900-41","in 10mM DMSO","PDE","Metabolism","Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.",474.58,"139755-83-2","N/A",">10","N/A","N/A","http://selleckchem.com/products/sildenafil.html","C22H30N6O4S","free base","Revatio, UK-92480, Viagra","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4",2.247,6,1,7]
["S7654","Defactinib (VS-6063)","b10","L3900-41","in 10mM DMSO","FAK","Angiogenesis","Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.",510.49,"1073154-85-4",{"v":100,"d":"100.00"},{"v":195.8,"d":"195.80"},"<1","N/A","http://selleckchem.com/products/defactinib.html","C20H21F3N8O3S","free base","PF-04554878","CNC(=O)C1=CC=C(NC2=NC(=C(C=N2)C(F)(F)F)NCC3=C(N=CC=N3)N(C)[S](C)(=O)=O)C=C1",1.774,7,3,9]
["S1037","Perifosine (KRX-0401)","a2","L3900-42","in 10mM Water","Akt","PI3K/Akt/mTOR","Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.",461.66,"157716-52-4","<1","N/A",{"v":8,"d":"8.00"},17.33,"http://selleckchem.com/products/Perifosine.html","C25H52NO4P","free base","NSC639966, D21266","CCCCCCCCCCCCCCCCCCO[P]([O-])(=O)OC1CC[N+](C)(C)CC1",4.607,2,0,20]
["S1116","Palbociclib (PD-0332991) HCl","b2","L3900-42","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",483.99,"827022-32-2",{"v":3,"d":"3.00"},{"v":6.2,"d":"6.20"},{"v":30,"d":"30.00"},61.98,"http://selleckchem.com/products/PD-0332991.html","C24H29N7O2.HCl","Hydrochloride","N/A","Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O",3.183,5,2,5]
["S1135","Pemetrexed (LY-231514) disodium","c2","L3900-42","in 10mM Water","Apoptosis related,Autophagy,DHFR,DNA/RNA Synthesis,Thymidylate Synthase","Metabolism","Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.",471.37,"150399-23-8","<1","N/A",{"v":94,"d":"94.00"},199.42,"http://selleckchem.com/products/Pemetrexed-disodium.html","C20H19N5Na2O6","Disodium salt","LY-231514 disodium","[Na+].[Na+].NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N1",-1.804,3,4,9]
["S1149","Gemcitabine (LY-188011) HCl","d2","L3900-42","in 10mM Water","Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.",299.66,"122111-03-9","<1","N/A",{"v":19,"d":"19.00"},63.41,"http://selleckchem.com/products/Gemcitabine-Hydrochloride(Gemzar).html","C9H11F2N3O4.HCI","Hydrochloride","NSC 613327,LY-188011 HCl","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.012,3,3,2]
["S1311","Pamidronate Disodium","e2","L3900-42","in 10mM Water","Others","Others","Pamidronate Disodium (CGP 23339AE) is a nitrogen containing bisphosphonate, used to prevent osteoporosis.",279.03,"57248-88-1","<1","N/A",{"v":56,"d":"56.00"},{"v":200.7,"d":"200.70"},"http://selleckchem.com/products/Pamidronate-Disodium.html","C3H9NNa2O7P2","Disodium salt","CGP 23339AE","[Na+].[Na+].NCCC(O)([P](O)([O-])=O)[P](O)([O-])=O",-5.016,0,1,4]
["S1338","Gabapentin HCl","f2","L3900-42","in 10mM Water","GABA Receptor","Neuronal Signaling","Gabapentin HCl(Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.",{"v":207.7,"d":"207.70"},"60142-95-2","<1","N/A",{"v":42,"d":"42.00"},202.21,"http://selleckchem.com/products/Gabapentin.html","C9H17NO2.HCl","Hydrochloride","Neurontin HCl","Cl.NCC1(CCCCC1)CC(O)=O",-1.104,1,1,3]
["S1339","Galanthamine HBr","g2","L3900-42","in 10mM Water","AChR,ADC Cytotoxin","Neuronal Signaling","Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.",368.27,"1953-04-4","<1","N/A",{"v":36,"d":"36.00"},97.75,"http://selleckchem.com/products/Galanthamine-hydrobromide.html","C17H21NO3.HBr","Hydrobromide","N/A","Br.COC1=CC=C2CN(C)CCC34C=CC(O)CC3OC1=C24",1.933,2,1,1]
["S1345","Granisetron HCl","h2","L3900-42","in 10mM Water","5-HT Receptor","Neuronal Signaling","Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.",348.87,"107007-99-8",{"v":1,"d":"1.00"},2.87,{"v":69,"d":"69.00"},197.78,"http://selleckchem.com/products/Granisetron-Hydrochloride.html","C18H24N4O.HCl","Hydrochloride","N/A","Cl.CN1C2CCCC1CC(C2)NC(=O)C3=N[N](C)C4=CC=CC=C34",2.783,2,1,2]
["S1370","Biapenem","a3","L3900-42","in 10mM Water","Antibiotics,Bacterial","Microbiology","Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.",350.39,"120410-24-4","<1","N/A",{"v":16,"d":"16.00"},45.66,"http://selleckchem.com/products/Biapenem.html","C15H18N4O4S","free base","L-627, LJC10627","CC(O)C1C2C(C)C(=C(N2C1=O)C([O-])=O)SC3C[N]4C=NC=[N+]4C3",-2.248,2,1,4]
["S1375","Dorzolamide HCl","b3","L3900-42","in 10mM Water","Carbonic Anhydrase","Metabolism","Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.",{"v":360.9,"d":"360.90"},"130693-82-2","<1","N/A",{"v":14,"d":"14.00"},38.79,"http://selleckchem.com/products/Dorzolamide-HCL.html","C10H16N2O4S3.HCl","Hydrochloride","MK-507 (L-671152) HCl","Cl.CCNC1CC(C)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",0.527,4,2,3]
["S1384","Mizoribine","c3","L3900-42","in 10mM Water","DNA/RNA Synthesis,HCV","DNA Damage/DNA Repair","Mizoribine (Bredinin, NSC 289637,HE 69) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.",259.22,"50924-49-7",{"v":1,"d":"1.00"},3.86,{"v":51,"d":"51.00"},196.74,"http://selleckchem.com/products/Mizoribine.html","C9H13N3O6","free base","Bredinin, NSC 289637,HE 69","NC(=O)C1=C(O)[N](C=N1)C2OC(CO)C(O)C2O",-2.409,3,5,3]
["S1395","Polymyxin B sulphate","d3","L3900-42","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antineoplastic and Immunosuppressive Antibiotics","Microbiology","Polymyxin B (Aerosporin, PMB, Poly-RX) is an antibiotic primarily used for resistant gram-negative infections.",1301.56,"1405-20-5, 4135-11-9 (free base)","<1","N/A",{"v":100,"d":"100.00"},76.83,"http://selleckchem.com/products/Polymyxin-B-sulphate.html","C56H98N16O13.H2SO4","sulfate","Aerosporin, PMB, Poly-RX","CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O.O[S](O)(=O)=O",-6.873,11,18,29]
["S1399","Teicoplanin","e3","L3900-42","in 10mM Water","Antibiotics,Bacterial","Microbiology","Teicoplanin (Teichomycin,Targocid,MDL-507) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.",1709.39,"61036-62-2","<1","N/A",{"v":100,"d":"100.00"},{"v":58.5,"d":"58.50"},"http://selleckchem.com/products/Teicoplanin.html","C77H77N9O31Cl2.R","free base","Teichomycin,Targocid,MDL-507","CCCCCCCCCC(C)=O.CCCCC\\C=C\\CCC(C)=O.CCC(C)CCCCCCC(C)=O.CC(C)CCCCCCCC(C)=O.CC(C)CCCCCCC(C)=O.CC(=O)NC1C(O)C(O)C(CO)OC1OC2C3NC(=O)C(NC(=O)C4NC(=O)C5NC(=O)C(CC6=CC=C(OC7=C(OC8OC(CO)C(O)C(O)C8N[R])C(=CC4=C7)OC9=C(Cl)C=C2C=C9)C(=C6)Cl)NC(=O)C(N)C%10=CC(=C(O)C=C%10)OC%11=CC5=CC(=C%11)O)C%12=CC(=C(O)C=C%12)C%13=C(OC%14OC(CO)C(O)C(O)C%14O)C=C(O)C=C%13C(NC3=O)C(O)=O",14.847,22,23,50]
["S1440","Varenicline Tartrate (CP 526555-18)","f3","L3900-42","in 10mM Water","AChR","Neuronal Signaling","Varenicline Tartrate (CP 526555-18, Chantix, Champix) is a nicotinic AChR partial agonist, used to treat nicotine addiction.",361.35,"375815-87-5",{"v":1,"d":"1.00"},2.77,{"v":72,"d":"72.00"},199.25,"http://selleckchem.com/products/Varenicline-tartrate.html","C13H13N3.C4H6O6","Tartrate","Chantix, Champix,CP 526555-18","OC(C(O)C(O)=O)C(O)=O.C1NCC2CC1C3=C2C=C4N=CC=NC4=C3",{"v":-3.33,"d":"-3.330"},4,3,3]
["S1494","Ralimetinib (LY2228820) dimesylate","g3","L3900-42","in 10mM Water","p38 MAPK","MAPK","Ralimetinib (LY2228820) dimesylate is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, does not alter p38 MAPK activation. Phase 1/2.",612.74,"862507-23-1",{"v":4,"d":"4.00"},6.53,{"v":100,"d":"100.00"},{"v":163.2,"d":"163.20"},"http://selleckchem.com/products/LY2228820.html","C24H29FN6.2CH4O3S","dimesylate","N/A","CC(C)(C)C[N]1C(=NC2=CC=C(N=C12)C3=C(N=C([NH]3)C(C)(C)C)C4=CC=C(F)C=C4)N.C[S;v6](O)(=O)=O",5.117,3,2,5]
["S1506","Perindopril Erbumine","h3","L3900-42","in 10mM Water","RAAS","Endocrinology & Hormones","Perindopril Erbumine (S9490-3) is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite, a potent ACE inhibitor with IC50 of 1.05 nM. Perindopril Erbumine is used for in vivo studies and Perindoprilat is recommened for in vitro research.",{"v":441.6,"d":"441.60"},"107133-36-8","<1","N/A",{"v":88,"d":"88.00"},199.28,"http://selleckchem.com/products/Perindopril-Erbumine(Aceon).html","C19H32N2O5.C4H11N","t-Butylamine","S9490-3","CCCC(NC(C)C(=O)N1C2CCCCC2CC1C(O)=O)C(=O)OCC.CC(C)(C)N",0.016,4,2,9]
["S1516","Cidofovir","a4","L3900-42","in 10mM Water","CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Cidofovir (HPMPC,Vistide,GS 0504) suppresses virus replication by selective inhibition of viral DNA synthesis.",279.19,"113852-37-2",{"v":2,"d":"2.00"},7.16,{"v":12,"d":"12.00"},42.98,"http://selleckchem.com/products/Cidofovir.html","C8H14N3O6P","Free Base","HPMPC,Vistide,GS 0504","NC1=NC(=O)N(CC(CO)OC[P](O)(O)=O)C=C1",-2.175,3,2,6]
["S1518","Ibuprofen Lysine","b4","L3900-42","in 10mM Water","COX","Neuronal Signaling","Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.",352.47,"57469-77-9","<1","N/A",{"v":71,"d":"71.00"},201.44,"http://selleckchem.com/products/Ibuprofen-Lysine(Motrin).html","C19H32N2O4","Lysine","N/A","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O.NCCCCC(N)C(O)=O",-2.112,2,2,9]
["S1579","Palbociclib (PD0332991) Isethionate","c4","L3900-42","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",573.66,"827022-33-3","<1","N/A",{"v":10,"d":"10.00"},17.43,"http://selleckchem.com/products/pd-0332991-palbociclib-isethionate.html","C24H29N7O2.C2H6O4S","Isethionate","N/A","CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O.OCC[S](O)(=O)=O",1.847,5,3,7]
["S1624","Alendronate sodium trihydrate","d4","L3900-42","in 10mM Water","Others","Metabolism","Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.",326.13,"121268-17-5","<1","N/A",{"v":20,"d":"20.00"},61.33,"http://selleckchem.com/products/Alendronate-Sodium(Fosamax).html","C4H13NO7P2.3H2O.Na","Sodium Salt","G-704650, MK-217","O.O.O.NCCCC(O)([P](O)(O)=O)[P](O)(=O)O[Na]",{"v":0,"d":"0.000"},0,0,0]
["S1648","Cytarabine (U-19920A)","e4","L3900-42","in 10mM Water","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459,U-19920A) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.",243.22,"147-94-4",{"v":1,"d":"1.00"},4.11,{"v":48,"d":"48.00"},197.35,"http://selleckchem.com/products/Cytarabine(Cytosar-U).html","C9H13N3O5","free base","Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459,U-19920A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S1749","L-Glutamine","f4","L3900-42","in 10mM Water","Others","Others","L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.",146.14,"56-85-9","<1","N/A",{"v":29,"d":"29.00"},198.44,"http://selleckchem.com/products/Glutamine.html","C5H10N2O3","free base","N/A","NC(CCC(N)=O)C(O)=O",-4.087,2,2,4]
["S1751","Gadodiamide Hydrate","g4","L3900-42","in 10mM Water","Others","Others","Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.",591.67,"122795-43-1","<1","N/A",{"v":100,"d":"100.00"},169.01,"http://selleckchem.com/products/Gadodiamide(Omniscan).html","C16H28GdN5O9C16H28GdN5O9.xH2O","Hydrate","N/A","O.[Gd+3].CNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O)CC([O-])=O",-7.468,2,2,16]
["S1853","Penicillamine","h4","L3900-42","in 10mM Water","Others","Others","Penicillamine (Dimethyl Cysteine) is used as an antirheumatic and as a chelating agent in Wilson’s disease.",149.21,"52-67-5","<1","N/A",{"v":30,"d":"30.00"},201.06,"http://selleckchem.com/products/Penicillamine(Cuprimine).html","C5H11NO2S","free base","Dimethyl Cysteine","CC(C)(S)C(N)C(O)=O",-2.496,1,1,2]
["S1875","Tranexamic Acid","a5","L3900-42","in 10mM Water","Others","Others","Tranexamic Acid(Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.",157.21,"1197-18-8","<1","N/A",{"v":31,"d":"31.00"},197.19,"http://selleckchem.com/products/tranexamic-acid-transamin.html","C8H15NO2","free base","Transamin","NCC1CCC(CC1)C(O)=O",-1.753,1,1,2]
["S1939","Levamisole hydrochloride","b5","L3900-42","in 10mM Water","Immunology & Inflammation related","Immunology & Inflammation","Levamisole, also known as (-)-Tetramisole, is an inhibitor of alkaline phosphatase, used as an anthelmintic.",240.75,"16595-80-5","<1","N/A",{"v":48,"d":"48.00"},199.38,"http://selleckchem.com/products/Levamisole-Hydrochloride(Ergamisol).html","C11H12N2S.HCl","Hydrochloride","(-)-Tetramisole hydrochloride","Cl.C1CN2CC(N=C2S1)C3=CC=CC=C3",2.672,1,0,1]
["S1984","Ticlopidine HCl","c5","L3900-42","in 10mM Water","P2 Receptor","Neuronal Signaling","Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.",300.25,"53885-35-1",{"v":1,"d":"1.00"},3.33,{"v":4,"d":"4.00"},13.32,"http://selleckchem.com/products/ticlopidine-hydrochloride.html","C14H14ClNS.HCl","Hydrochloride","N/A","Cl.ClC1=C(CN2CCC3=C(C2)C=CS3)C=CC=C1",4.275,0,0,2]
["S1985","ATP disodium","d5","L3900-42","in 10mM Water","Others","Others","ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.",551.14,"987-65-5","<1","N/A",{"v":100,"d":"100.00"},181.44,"http://selleckchem.com/products/atp-Adenosine-Triphosphate.html","C10H14N5O13P3.2Na","Disodium Salt","Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate","[Na+].[Na+].NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(=O)O[P]([O-])(=O)O[P](O)([O-])=O)C(O)C3O",-5.474,7,3,8]
["S1995","Procarbazine HCl","e5","L3900-42","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.",257.76,"366-70-1","<1","N/A",{"v":52,"d":"52.00"},201.74,"http://selleckchem.com/products/procarbazine-hydrochloride-matulane.html","C12H19N3O.HCl","Hydrochloride","NSC-77213 HCl","Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C",{"v":1.12,"d":"1.120"},1,3,5]
["S1998","D-Cycloserine","f5","L3900-42","in 10mM Water","Antibiotics,Selection Antibiotics for Transfected Cell","Microbiology","D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.",102.09,"68-41-7","<1","N/A",{"v":20,"d":"20.00"},195.91,"http://selleckchem.com/products/D-Cycloserine.html","C3H6N2O2","free base","RO-1-9213","NC1CONC1=O",-1.788,2,2,0]
["S1999","Sodium butyrate","g5","L3900-42","in 10mM Water","Apoptosis related,Autophagy,HDAC","Epigenetics","Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.",110.09,"156-54-7","<1","N/A",{"v":22,"d":"22.00"},199.84,"http://selleckchem.com/products/Sodium-butyrate.html","C4H7NaO2","Sodium Salt","NaB, Butanoic acid sodium salt","[Na+].CCCC([O-])=O",-0.556,0,0,2]
["S2048","Clindamycin Phosphate","h5","L3900-42","in 10mM Water","Antibiotics","Microbiology","Clindamycin Phosphate (NSC 618653) is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM.",504.96,"24729-96-2","<1","N/A",{"v":101,"d":"101.00"},200.02,"http://selleckchem.com/products/clindamycin-phosphate.html","C18H34ClN2O8PS","free base","NSC 618653","CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O[P](O)(O)=O)C(O)C2O",1.205,3,3,9]
["S2076","Lisinopril dihydrate","a6","L3900-42","in 10mM Water","ACE,RAAS","Endocrinology & Hormones","Lisinopril dihydrate(MK-521 dihydrate) is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.",441.52,"83915-83-7","<1","N/A",{"v":20,"d":"20.00"},49.32,"http://selleckchem.com/products/lisinopril-zestril.html","C21H35N3O7","free base","MK-521 dihydrate","NCCCCC(NC(CCC1=CC=CC=C1)C(O)=O)C(=O)N2CCCC2C(O)=O",-3.673,3,2,12]
["S2129","Fudosteine","b6","L3900-42","in 10mM Water","Others","Metabolism","Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.",179.24,"13189-98-5","<1","N/A",{"v":36,"d":"36.00"},200.85,"http://selleckchem.com/products/Fudosteine.html","C6H13NO3S","free base","N/A","NC(CSCCCO)C(O)=O",-3.373,1,2,6]
["S2133","Gabapentin","c6","L3900-42","in 10mM Water","GABA Receptor","Neuronal Signaling","Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.",171.24,"60142-96-3","<1","N/A",{"v":34,"d":"34.00"},198.55,"http://selleckchem.com/products/Gabapentin(Neurontin).html","C9H17NO2","Free Base","N/A","NCC1(CCCCC1)CC(O)=O",-1.486,1,1,3]
["S2315","Kanamycin sulfate","d6","L3900-42","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.",582.58,"25389-94-0","<1","N/A",{"v":52,"d":"52.00"},89.26,"http://selleckchem.com/products/Kanamycin-sulfate(Kantrex).html","C18H38N4O15S","sulfate","Kanamycin monosulfate, Ophtalmokalixan","NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(O)C(O)C1O.O[S](O)(=O)=O",-7.751,4,11,6]
["S2416","Chondroitin sulfate","e6","L3900-42","in 10mM Water","NF-κB","NF-κB","Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons. It reduces the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes in vitro.",489.45,"9007-28-7","N/A","N/A",{"v":97,"d":"97.00"},198.18,"http://selleckchem.com/products/chondroitin-sulfate.html","(C14H21NO14S)n","sulfate","N/A","COC1OC(CO[S](O)(=O)=O)C(O)C(OC2OC(C(C)C(O)C2O)C(O)=O)C1NC(C)=O",-2.447,7,4,8]
["S2462","Donepezil HCl","f6","L3900-42","in 10mM Water","AChR","Neuronal Signaling","Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.",{"v":416,"d":"416.00"},"120011-70-3","<1","N/A",{"v":5,"d":"5.00"},12.02,"http://selleckchem.com/products/Donepezil-hydrochloride(Aricept).html","C24H29NO3.HCl","Hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)CC2=C1",4.951,3,0,6]
["S2490","Neostigmine Bromide","g6","L3900-42","in 10mM Water","AChR","Neuronal Signaling","Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.",{"v":303.2,"d":"303.20"},"114-80-7","<1","N/A",{"v":60,"d":"60.00"},197.89,"http://selleckchem.com/products/Neostigmine-bromide(Prostigmin).html","C12H19N2O2.Br","Bromide","N/A","[Br-].CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C",-1.907,2,0,3]
["S2507","Salbutamol Sulfate","h6","L3900-42","in 10mM Water","Adrenergic Receptor","Neuronal Signaling","Salbutamol Sulfate (Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.",337.39,"51022-70-9","<1","N/A",{"v":68,"d":"68.00"},201.55,"http://selleckchem.com/products/Salbutamol-sulfate(Albuterol).html","C13H21NO3.H2SO4","Sulfate","Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent","CC(C)(C)NCC(O)C1=CC=C(O)C(=C1)CO.O[S](O)(=O)=O",0.334,0,4,5]
["S2514","Tobramycin","a7","L3900-42","in 10mM Water","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics","Microbiology","Tobramycin (NSC 180514,Deoxykanamycin B, Nebramycin Factor 6) is an aminoglycoside antibiotic with an IC50 of 9.7 μM.",467.52,"32986-56-4","<1","N/A",{"v":94,"d":"94.00"},201.06,"http://selleckchem.com/products/Tobramycin(free-base).html","C18H37N5O9","free base","NSC 180514,Deoxykanamycin B, Nebramycin Factor 6","NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O",{"v":-6.86,"d":"-6.860"},4,10,6]
["S2518","NAD+","b7","L3900-42","in 10mM Water","Others","Others","NAD+ (β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.",663.43,"53-84-9","<1","N/A",{"v":100,"d":"100.00"},150.73,"http://selleckchem.com/products/nad.html","C21H27N7O14P2","free base","β-DPN, β-NAD, β-Nicotinamide Adenine Dinucleotide,nicotinamide adenine dinucleotide","NC(=O)C1=CC=C[N+](=C1)C2OC(CO[P]([O-])(=O)O[P](O)(=O)OCC3OC(C(O)C3O)[N]4C=NC5=C(N)N=CN=C45)C(O)C2O",-4.524,9,6,11]
["S2539","Lomefloxacin HCl","c7","L3900-42","in 10mM Water","Antibiotics","Microbiology","Lomefloxacin HCl is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic.",387.81,"98079-52-8",{"v":1,"d":"1.00"},2.58,{"v":6,"d":"6.00"},15.47,"http://selleckchem.com/products/Lomefloxacin-hydrochloride-Maxaquin.html","C17H19F2N3O3.HCl","Hydrochloride","N/A","Cl.CCN1C=C(C(O)=O)C(=O)C2=CC(=C(N3CCNC(C)C3)C(=C12)F)F",-0.446,2,1,3]
["S2560","Amiloride HCl dihydrate","d7","L3900-42","in 10mM Water","Sodium Channel","Transmembrane Transporters","Amiloride HCl dihydrate(MK-870 hydrochloride dihydrate) is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.",302.12,"17440-83-4",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":17,"d":"17.00"},56.27,"http://selleckchem.com/products/amilorida.html","C6H8ClN7O.HCl.2H2O","hydrochloride & dihydrate","MK-870 hydrochloride dihydrate","O.O.Cl.NC(=N)NC(=O)C1=NC(=C(N)N=C1N)Cl",{"v":-0.78,"d":"-0.780"},3,4,2]
["S2563","Oxacillin sodium monohydrate","e7","L3900-42","in 10mM Water","Antibiotics,Bacterial","Microbiology","Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.",441.43,"7240-38-2","<1","N/A",{"v":88,"d":"88.00"},199.35,"http://selleckchem.com/products/Oxacillin-sodium-monohydrate.html","C19H18N3O5S.Na.H2O","Sodium Salt & hydrate","Methicillin","O.[Na+].CC1=C(C(=O)NC2C3SC(C)(C)C(N3C2=O)C([O-])=O)C(=NO1)C4=CC=CC=C4",-0.046,4,1,4]
["S2568","Neomycin sulfate","f7","L3900-42","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Neomycin sulfate(Framycin sulfate) is an aminoglycoside antibiotic, used to treat bacteria infections.",712.72,"28002-70-2 ,1405-10-3","<1","N/A",{"v":143,"d":"143.00"},200.64,"http://selleckchem.com/products/Neomycin-sulfate.html","C23H46N6O13.H2SO4","Sulfate","Framycin sulfate","NCC1OC(OC2C(N)CC(N)C(O)C2OC3OC(CO)C(OC4OC(CN)C(O)C(O)C4N)C3O)C(N)C(O)C1O.O[S](O)(=O)=O",-9.566,6,13,9]
["S2572","Streptomycin sulfate","g7","L3900-42","in 10mM Water","Antibiotics for Plant Cell Culture,Anti-infection,Selection Antibiotics for Transfected Cell","Microbiology","Streptomycin sulfate(Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.",1457.38,"3810-74-0","<1","N/A",{"v":89,"d":"89.00"},61.07,"http://selleckchem.com/products/streptomycin-sulfate.html","2C21H39N7O12.3H2SO4","1.5 Sulfate","Phytomycin","CNC1C(O)C(O)C(CO)OC1OC2C(OC(C)C2(O)C=O)OC3C(O)C(O)C(NC(N)=N)C(O)C3NC(N)=N.CNC4C(O)C(O)C(CO)OC4OC5C(OC(C)C5(O)C=O)OC6C(O)C(O)C(NC(N)=N)C(O)C6NC(N)=N.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-14.403,10,22,22]
["S2575","Vancomycin HCl","h7","L3900-42","in 10mM Water","Bacterial","Microbiology","Vancomycin HCl is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.",1485.71,"1404-93-9","<1","N/A",{"v":100,"d":"100.00"},67.31,"http://selleckchem.com/products/vancomycin-hydrochloride-vancocin.html","C66H75Cl2N9O24.HCl","HCl","N/A","Cl.CNC(CC(C)C)C(=O)NC1C(O)C2=CC=C(OC3=CC4=CC(=C3OC5OC(CO)C(O)C(O)C5OC6CC(C)(N)C(O)C(C)O6)OC7=CC=C(C=C7Cl)C(O)C8NC(=O)C(NC(=O)C4NC(=O)C(CC(N)=O)NC1=O)C9=CC(=C(O)C=C9)C%10=C(C=C(O)C=C%10O)C(NC8=O)C(O)=O)C(=C2)Cl",-2.544,14,18,13]
["S2877","L-NAME HCl","a8","L3900-42","in 10mM Water","NOS","Immunology & Inflammation","L-NAME HCl (NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester) is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.",269.69,"51298-62-5","<1","N/A",{"v":54,"d":"54.00"},200.23,"http://selleckchem.com/products/l-name-hcl.html","C7H15N5O4.HCl","Hydrochloride","NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester","Cl.COC(=O)C(N)CCCNC(=N)N[N+]([O-])=O",1.463,2,3,9]
["S2879","AMD3465 hexahydrobromide","b8","L3900-42","in 10mM Water","CXCR","GPCR & G Protein","AMD3465 is a monomacrocyclic CXCR4 antagonist.",896.07,"185991-07-5, 185991-24-6 (free base)",{"v":2,"d":"2.00"},2.23,{"v":98,"d":"98.00"},109.37,"http://selleckchem.com/products/amd3465.html","C24H38N6.6HBr","HBr","N/A","Br.Br.Br.Br.Br.Br.C1CNCCNCCCN(CCNC1)CC2=CC=C(CNCC3=NC=CC=C3)C=C2",3.787,1,4,6]
["S3007","Zanamivir","c8","L3900-42","in 10mM Water","Influenza Virus,Neuraminidase","Microbiology","Zanamivir (GG167,GR 121167X) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.",332.31,"139110-80-8",{"v":2,"d":"2.00"},6.02,{"v":25,"d":"25.00"},75.23,"http://selleckchem.com/products/zanamivir-relenza.html","C12H20N4O7","free base","GG167,GR 121167X","CC(=O)NC1C(NC(N)=N)C=C(OC1C(O)C(O)CO)C(O)=O",-3.395,3,6,7]
["S3013","Plerixafor (AMD3100) 8HCl","d8","L3900-42","in 10mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.",794.47,"155148-31-5","<1","N/A",{"v":100,"d":"100.00"},125.87,"http://selleckchem.com/products/plerixafor-8hcl-db06809.html","C28H54N8.8HCl","Octahydrochloride","JM 3100 8HCl,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride","Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",2.536,0,6,4]
["S3048","Solifenacin succinate","e8","L3900-42","in 10mM Water","AChR","Neuronal Signaling","Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class.",480.55,"242478-38-2",{"v":3,"d":"3.00"},6.24,{"v":96,"d":"96.00"},199.77,"http://selleckchem.com/products/solifenacin-succinate.html","C23H26N2O.C4H6O4","Succinate","YM905","OC(=O)CCC(O)=O.O=C(OC1CN2CCC1CC2)N3CCC4=C(C=CC=C4)C3C5=CC=CC=C5",0.635,4,0,6]
["S3050","Palonosetron HCl","f8","L3900-42","in 10mM Water","5-HT Receptor","Neuronal Signaling","Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.",332.87,"135729-62-3","<1","N/A",{"v":67,"d":"67.00"},201.28,"http://selleckchem.com/products/palonosetron-hcl.html","C19H24N2O.HCl","HCL","RS 25259, RS 25259 197","Cl.O=C1N(CC2CCCC3=CC=CC1=C23)C4CN5CCC4CC5",3.127,1,0,1]
["S3056","Miltefosine","g8","L3900-42","in 10mM Water","Akt","PI3K/Akt/mTOR","Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.",407.57,"58066-85-6","<1","N/A",{"v":81,"d":"81.00"},198.74,"http://selleckchem.com/products/miltefosine-hexadecylphosphocholine.html","C21H46NO4P","free base","Hexadecylphosphocholine","CCCCCCCCCCCCCCCCO[P]([O-])(=O)OCC[N+](C)(C)C",3.722,2,0,20]
["S3065","Amikacin disulfate","h8","L3900-42","in 10mM Water","Bacterial","Microbiology","Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.",781.76,"39831-55-5","<1","N/A",{"v":10,"d":"10.00"},12.79,"http://selleckchem.com/products/amikacin-sulfate.html","C22H43N5O13.2H2SO4","Sulfate","BB-K8","NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC3OC(CO)C(O)C(N)C3O.O[S](O)(=O)=O.O[S](O)(=O)=O",{"v":-9.64,"d":"-9.640"},5,13,10]
["S3072","(R)-baclofen","a9","L3900-42","in 10mM Water","GABA Receptor","Neuronal Signaling","(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.",213.66,"69308-37-8","<1","N/A",{"v":8,"d":"8.00"},37.44,"http://selleckchem.com/products/r-baclofen.html","C10H12ClNO2","free base","STX 209","NCC(CC(O)=O)C1=CC=C(Cl)C=C1",{"v":-1.06,"d":"-1.060"},1,1,4]
["S3073","Caspofungin (MK-0991) Acetate","b9","L3900-42","in 10mM Water","Fungal","Microbiology","Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.",1213.42,"179463-17-3","N/A","N/A",{"v":100,"d":"100.00"},82.41,"http://selleckchem.com/products/caspofungin-acetate.html","C52H88N10O15.2C2H4O2","diacetate","L-743872","CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(O)C(NCCN)NC(=O)C2C(O)CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(O)CN3C(=O)C(NC1=O)C(C)O)C(O)C(O)C4=CC=C(O)C=C4)C(O)CCN.CC(O)=O.CC(O)=O",-8.482,9,16,23]
["S3102","Creatinine","c9","L3900-42","in 10mM Water","Others","Others","Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.",113.12,"60-27-5","<1","N/A",{"v":23,"d":"23.00"},203.32,"http://selleckchem.com/products/creatinine.html","C4H7N3O","free base","NSC13123","CN1CC(=O)NC1=N",{"v":-0.9,"d":"-0.900"},1,1,0]
["S3122","Amikacin hydrate","d9","L3900-42","in 10mM Water","Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Amikacin(BAY416651 hydrate) is an aminoglycoside antibiotic used to treat different types of bacterial infections.","585.6+x18","1257517-67-1","<1","N/A",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"http://selleckchem.com/products/amikacin-hydrate.html","C22H43N5O13.xH2O","Hydrate","BAY416651 hydrate","O.NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC3OC(CO)C(O)C(N)C3O",{"v":0,"d":"0.000"},0,0,0]
["S3148","Ibandronate sodium monohydrate","e9","L3900-42","in 10mM Water","Others","Others","Ibandronate (BM-21.0955, BM-210955, RPR-102289A) is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.",360.23,"138926-19-9","<1","N/A",{"v":72,"d":"72.00"},199.87,"http://selleckchem.com/products/ibandronate-sodium.html","C9H23NO7P2.Na.H2O","sodium monohydrate","BM-21.0955, BM-210955, RPR-102289A","O.[NaH].CCCCCN(C)CCC(O)([P](O)(O)=O)[P](O)(O)=O",0.477,0,0,9]
["S3165","Abacavir sulfate","f9","L3900-42","in 10mM Water","Reverse Transcriptase","Microbiology","Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.",335.35,"188062-50-2","<1","N/A",{"v":36,"d":"36.00"},107.35,"http://selleckchem.com/products/abacavir-sulfate.html","C14H18N6O.1/2H2SO4","Sulfate","1592U89","NC1=NC2=C(N=C[N]2C3CC(CO)C=C3)C(=N1)NC4CC4.NC5=NC6=C(N=C[N]6C7CC(CO)C=C7)C(=N5)NC8CC8.O[S](O)(=O)=O",0.932,6,6,8]
["S3174","L-Arginine HCl (L-Arg)","g9","L3900-42","in 10mM Water","NOS","Immunology & Inflammation","L-Arginine(L-Arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.",210.66,"1119-34-2","<1","N/A",{"v":42,"d":"42.00"},199.37,"http://selleckchem.com/products/l-Arginine-hydrochloride.html","C6H14N4O2.HCl","HCl","(S)-(+)-Arginine hydrochloride","Cl.NC(CCCNC(N)=N)C(O)=O",-3.449,1,3,6]
["S3211","Thiamine HCl (Vitamin B1)","h9","L3900-42","in 10mM Water","Vitamin","Metabolism","Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes.",337.27,"67-03-8","<1","N/A",{"v":68,"d":"68.00"},201.62,"http://selleckchem.com/products/thiamine-hcl-vitamin-b1.html","C12H17N4OS.HCl","Hydrochloride","N/A","Cl.[Cl-].CC1=NC=C(C[N+]2=CSC(=C2C)CCO)C(=N1)N",-1.244,2,2,4]
["S3649","Ceftazidime","a10","L3900-42","in 10mM Water","Anti-infection,Selection Antibiotics for Transfected Cell","Microbiology","Ceftazidime(GR20263) is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa.",546.58,"72558-82-8",{"v":4,"d":"4.00"},7.32,{"v":100,"d":"100.00"},182.96,"http://selleckchem.com/products/ceftazidime.html","C22H22N6O7S2","inner salt","GR20263","CC(C)(O\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3=CC=CC=C3)C4=CSC(=N4)N)C(O)=O",-0.693,6,2,9]
["S3650","Penicillin V potassium salt","b10","L3900-42","in 10mM Water","Antibiotics,Bacterial","Microbiology","Phenoxymethylpenicillin, also known as penicillin V, is an antibiotic useful for the treatment of a number of bacterial infections. It acts by inhibiting the biosynthesis of cell-wall peptidoglycan.",388.48,"132-98-9","<1","N/A",{"v":77,"d":"77.00"},198.21,"http://selleckchem.com/products/penicillin-v-potassium-salt.html","C16H17N2O5S.K","potassium salt","Phenoxymethylpenicillin potassium salt","[K+].CC1(C)SC2C(NC(=O)COC3=CC=CC=C3)C(=O)N2C1C([O-])=O",{"v":-0.55,"d":"-0.550"},3,1,5]
["S3662","Pirenzepine dihydrochloride","c10","L3900-42","in 10mM Water","AChR","Neuronal Signaling","Pirenzepine is an antimuscarinic agent which inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions.",424.32,"29868-97-1",{"v":1,"d":"1.00"},2.36,{"v":84,"d":"84.00"},197.96,"http://selleckchem.com/products/pirenzepine-dihydrochloride.html","C19H21N5O2.2HCl","dihydrochloride","N/A","Cl.Cl.CN1CCN(CC1)CC(=O)N2C3=C(C=CC=C3)C(=O)NC4=CC=CN=C24",1.803,3,1,2]
["S3667","Imipenem","d10","L3900-42","in 10mM Water","β-lactamase","Microbiology","Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections.",317.36,"74431-23-5",{"v":1,"d":"1.00"},3.15,{"v":63,"d":"63.00"},198.51,"http://selleckchem.com/products/imipenem.html","C12H17N3O4S.H2O","hydrate","N/A","O.CC(O)C1C2CC(=C(N2C1=O)C(O)=O)SCCNC=N",-1.825,2,2,7]
["S3737","Cangrelor Tetrasodium","e10","L3900-42","in 10mM Water","P2 Receptor","Neuronal Signaling","Cangrelor (AR-C69931MX) is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.",864.29,"163706-36-3",{"v":2,"d":"2.00"},2.31,{"v":100,"d":"100.00"},{"v":115.7,"d":"115.70"},"http://selleckchem.com/products/cangrelor-tetrasodium.html","21Cl2F3N5O12P3S2.4Na","tetrasodium salt","AR-C69931MX","CSCCNC1=NC(=NC2=C1N=C[N]2C3OC(CO[P](=O)(O[Na])O[P](=O)(O[Na])C(Cl)(Cl)[P](=O)(O[Na])O[Na])C(O)C3O)SCCC(F)(F)F",2.787,10,3,20]
["S3748","Acamprosate Calcium","f10","L3900-42","in 10mM Water","GABA Receptor","Transmembrane Transporters","Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate,N-acetylhomotaurinate) is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.",200.24,"77337-73-6","<1","N/A",{"v":40,"d":"40.00"},199.76,"http://selleckchem.com/products/acamprosate-calcium.html","C5H11NO4S.1/2Ca","calcium salt","N-Acetylhomotaurine Calcium, calcium acetylhomotaurinate,N-acetylhomotaurinate","CC(=O)NCCC[S]([O-])(=O)=O",{"v":-2.67,"d":"-2.670"},1,1,4]
["S3752","isoleucine","g10","L3900-42","in 10mM Water","Others","Others","Isoleucine (Ile) is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins.",131.17,"73-32-5","<1","N/A",{"v":26,"d":"26.00"},198.22,"http://selleckchem.com/products/isoleucine.html","C6H13NO2","free base","Ile","CCC(C)C(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3753","L-Leucine","h10","L3900-42","in 10mM Water","mTOR","PI3K/Akt/mTOR","Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing.  L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.",131.17,"61-90-5","<1","N/A",{"v":5,"d":"5.00"},38.12,"http://selleckchem.com/products/l-leucine.html","C6H13NO2","free base","(S)-Leucine, Leu","CC(C)CC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3793","Phytic acid","a11","L3900-42","in 10mM Water","Xanthine Oxidase","Metabolism","Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.",660.04,"83-86-3","<1","N/A",{"v":100,"d":"100.00"},151.51,"http://selleckchem.com/products/phytic-acid.html","C6H18O24P6","free base","Inositol polyphosphate, Inositol hexakisphosphate","O[P](O)(=O)OC1C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C1O[P](O)(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3798","L-Citrulline","b11","L3900-42","in 10mM Water","Others","Others","L-citrulline is a substance called a non-essential amino acid that is used as a sports performance and cardiovascular health supplement.",175.19,"372-75-8","<1","N/A",{"v":35,"d":"35.00"},199.78,"http://selleckchem.com/products/l-citrulline.html","C6H13N3O3","free base","N/A","NC(CCCNC(N)=O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3852","L-Theanine","c11","L3900-42","in 10mM Water","Others","Others","L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation.",{"v":174.2,"d":"174.20"},"3081-61-6","<1","N/A",{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-theanine.html","C7H14N2O3","free base","N/A","CCNC(=O)CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3973","L-SelenoMethionine","d11","L3900-42","in 10mM Water","ROS","Immunology & Inflammation","L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.",196.11,"3211-76-5","<1","N/A",{"v":39,"d":"39.00"},198.87,"http://selleckchem.com/products/l-selenomethionine.html","C5H11NO2Se","free base","N/A","C[Se]CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4008","Pemirolast potassium","e11","L3900-42","in 10mM Water","Histamine Receptor","Neuronal Signaling","Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.",{"v":266.3,"d":"266.30"},"100299-08-9","<1","N/A",{"v":53,"d":"53.00"},199.02,"http://selleckchem.com/products/pemirolast-bmy-26517-potassium.html","C10H7N6O.K","Potassium","BMY26517","[K+].CC1=CC=CN2C(=O)C(=CN=C12)C3=NN=N[N-]3",-1.246,5,0,1]
["S4013","Sodium Monofluorophosphate","f11","L3900-42","in 10mM Water","phosphatase","Metabolism","Sodium Monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.",143.95,"10163-15-2","<1","N/A",{"v":29,"d":"29.00"},201.46,"http://selleckchem.com/products/sodium-monofluorophosphate.html","FNa2O3P","Disodium salt","NSC248","[Na+].[Na+].[O-][P]([O-])(F)=O",-2.357,0,0,0]
["S4027","Flavoxate HCl","g11","L3900-42","in 10mM Water","AChR","Neuronal Signaling","Flavoxate (NSC-114649) is a muscarinic AChR antagonist with IC50 of 12.2 μM.",427.92,"3717-88-2",{"v":3,"d":"3.00"},7.01,{"v":10,"d":"10.00"},23.37,"http://selleckchem.com/products/flavoxate-hcl.html","C24H25NO4.HCl","hydrochloride","NSC-114649","Cl.CC1=C(OC2=C(C=CC=C2C(=O)OCCN3CCCCC3)C1=O)C4=CC=CC=C4",4.876,4,0,6]
["S4028","Dexamethasone Sodium Phosphate","h11","L3900-42","in 10mM Water","Autophagy,Complement System,COVID-19,COX,IL Receptor","Immunology & Inflammation","Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":516.4,"d":"516.40"},"55203-24-2","<1","N/A",{"v":103,"d":"103.00"},199.46,"http://selleckchem.com/products/dexamethasone-sodium-phosphate.html","C22H30FO8P.2Na","Disodium salt","Dexamethasone 21-phosphate disodium salt","[Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O",-0.541,3,1,4]
["S4029","Colistin Sulfate","a2","L3900-43","in 10mM Water","Bacterial","Microbiology","Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.",1400.63,"1264-72-8","<1","N/A",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"http://selleckchem.com/products/colistin-sulfate.html","C52H98N16O13.5/2H2SO4","Sulfate","Polymixin E Sulfate","CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O.CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC2CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC2=O)C(C)O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4030","Gentamicin Sulfate","b2","L3900-43","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.","N/A","1405-41-0","<1","N/A",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"http://selleckchem.com/products/gentamicin-sulfate.html","H2SO4.xUnspecified","Sulfate","NSC-82261, SCH9724","CCN.CNC(C)C.CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(CCC3N)[R])C2O.CC(C)N.O[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4052","Netilmicin Sulfate","c2","L3900-43","in 10mM Water","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics","Microbiology","Netilmicin Sulfate is a member of the aminoglycoside family of antibiotics.",1441.55,"56391-57-2","<1","N/A",{"v":288,"d":"288.00"},199.78,"http://selleckchem.com/products/netilmicin-sulfate.html","C21H41N5O7.2.5H2SO4","Sulfate","N/A","CCNC1CC(N)C(OC2OC(=CCC2N)CN)C(O)C1OC3OCC(C)(O)C(NC)C3O.CCNC4CC(N)C(OC5OC(=CCC5N)CN)C(O)C4OC6OCC(C)(O)C(NC)C6O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-10.844,8,14,16]
["S4093","Bismuth Subcitrate Potassium","d2","L3900-43","in 10mM Water","Antibiotics,Bacterial","Microbiology","Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.",782.67,"880149-29-1","<1","N/A",{"v":100,"d":"100.00"},127.77,"http://selleckchem.com/products/bismuth-subcitrate-potassium.html","C12H8BiK5O14","Potassium salt","N/A","[K+].[K+].[K+].[K+].[K+].[BiH6+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O",-11.482,0,0,10]
["S4108","Clodronate Disodium","e2","L3900-43","in 10mM Water","Others","Metabolism","Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.",288.86,"22560-50-5","<1","N/A",{"v":72,"d":"72.00"},249.26,"http://selleckchem.com/products/clodronate-disodium.html","CH4Cl2O6P0.2Na","Disodium salt","N/A","[Na+].[Na+].O[P]([O-])(=O)C(Cl)(Cl)[P](O)([O-])=O",-1.706,0,0,2]
["S4117","Histamine Phosphate","f2","L3900-43","in 10mM Water","Histamine Receptor","Neuronal Signaling","Histamine(Histamine diphosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.",307.14,"51-74-1","<1","N/A",{"v":42,"d":"42.00"},136.75,"http://selleckchem.com/products/histamine-phosphate.html","C5H9N.2H3O4P","Phosphate","Histamine diphosphate","NCCC1=C[NH]C=N1.O[P](O)(O)=O.O[P](O)(O)=O",-1.651,1,2,2]
["S4121","Succinylcholine Chloride Dihydrate","g2","L3900-43","in 10mM Water","AChR","Neuronal Signaling","Succinylcholine Chloride Dihydrate (Suxamethonium) is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.",397.34,"6101-15-1",{"v":1,"d":"1.00"},2.52,{"v":79,"d":"79.00"},198.82,"http://selleckchem.com/products/succinylcholine-suxamethonium-chloride-dihydrate.html","C14H30N2O4.2Cl.2H2O","Chloride","Suxamethonium Chloride Dihydrate","O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C",-8.102,4,0,11]
["S4127","Terbutaline Sulfate","h2","L3900-43","in 10mM Water","Adrenergic Receptor","GPCR & G Protein","Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.",548.65,"23031-32-5","<1","N/A",{"v":100,"d":"100.00"},182.27,"http://selleckchem.com/products/terbutaline-sulfate.html","C24H38N2O6.H2SO4","Sulfate","Terbutaline hemisulfate","CC(C)(C)NCC(O)C1=CC(=CC(=C1)O)O.CC(C)(C)NCC(O)C2=CC(=CC(=C2)O)O.O[S](O)(=O)=O",2.001,0,8,8]
["S4130","Mildronate","a3","L3900-43","in 10mM Water","Hydroxylase","Metabolism","Mildronate (Meldonium, MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.",147.19,"76144-81-5","<1","N/A",{"v":29,"d":"29.00"},197.02,"http://selleckchem.com/products/mildronate.html","C6H14N2O2","free base","Meldonium, MET-88, Quaterin","C[N+](C)(C)NCCC(O)=O",-1.797,1,1,4]
["S4146","Bacitracin","b3","L3900-43","in 10mM Water","Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.",1408.67,"1405-87-4","N/A","N/A",{"v":100,"d":"100.00"},70.99,"http://selleckchem.com/products/bacitracin.html","C65H101N17O16S","free base","N/A","CCC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C1CN=C(S1)C(N)C(C)C)C(=O)NC2CCCCNC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CC3=C[NH]C=N3)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(NC(=O)C(CCCN)NC2=O)C(C)CC",-6.458,16,15,30]
["S4157","Chloroquine diphosphate","c3","L3900-43","in 10mM Water","Anti-infection,ATM/ATR,Autophagy,COVID-19,TLR","PI3K/Akt/mTOR","Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).",515.86,"50-63-5","<1","N/A",{"v":100,"d":"100.00"},193.85,"http://selleckchem.com/products/chloroquine-phosphate.html","C18H26ClN3.2H3O4P","diphosphate","N/A","CCN(CC)CCCC(C)NC1=CC=NC2=C1C=CC(=C2)Cl.O[P](O)(O)=O.O[P](O)(O)=O",3.408,1,1,8]
["S4158","Ceftriaxone disodium salt hemi (heptahydrate)","d3","L3900-43","in 10mM Water","Antibiotics","Microbiology","Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.",{"v":661.6,"d":"661.60"},"104376-79-6",{"v":1,"d":"1.00"},1.51,{"v":100,"d":"100.00"},151.15,"http://selleckchem.com/products/ceftriaxone-sodium-trihydrate.html","C18H16N8O7S3.7/2H2O.2Na","disodium salt hemi","N/A","O.[Na;v0].CO\\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)CSC3=NC(=O)C(=O)NN3C)C4=CSC(=N4)N",-1.716,8,2,8]
["S4174","Sodium Gluconate","e3","L3900-43","in 10mM Water","Others","Others","Sodium gluconate is the sodium salt of gluconic acid widely used in food and pharmaceutical industry.",218.14,"527-07-1","<1","N/A",{"v":44,"d":"44.00"},201.71,"http://selleckchem.com/products/sodium-gluconate.html","C6H11O7.Na","Sodium salt","527-07-1","[Na+].OCC(O)C(O)C(O)C(O)C([O-])=O",-4.287,0,5,5]
["S4180","Nefopam HCl","f3","L3900-43","in 10mM Water","Sodium Channel","Transmembrane Transporters","Nefopam HCl(Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.",{"v":289.8,"d":"289.80"},"23327-57-3",{"v":1,"d":"1.00"},3.45,{"v":21,"d":"21.00"},72.46,"http://selleckchem.com/products/nefopam-hcl.html","C17H19NO.HCl","Hydrochloride","Fenazoxine hydrochloride","Cl.CN1CCOC(C2=CC=CC=C2)C3=C(C1)C=CC=C3",{"v":3.52,"d":"3.520"},1,0,1]
["S4183","Paromomycin Sulfate","g3","L3900-43","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antibiotics for Plant Cell Culture,Selection Antibiotics for Transfected Cell","Microbiology","Paromomycin Sulfate(Aminosidine sulfate) is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.",713.71,"1263-89-4","<1","N/A",{"v":100,"d":"100.00"},140.11,"http://selleckchem.com/products/paromomycin-sulfate.html","C23H45N5O14.xH2SO4","Sulfate","Aminosidine sulfate","NCC1OC(OC2C(O)C(OC2CO)OC3C(O)C(N)CC(N)C3OC4OC(CO)C(O)C(O)C4N)C(N)C(O)C1O.O[S](O)(=O)=O",-9.277,6,13,9]
["S4234","Capreomycin Sulfate","h3","L3900-43","in 10mM Water","Antibiotics","Microbiology","Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.",750.78,"1405-37-4","<1","N/A",{"v":100,"d":"100.00"},133.19,"http://selleckchem.com/products/capreomycin-sulfate.html","C25H44N14O7.H2SO4","Sulfate","N/A","CC1NC(=O)C(N)CNC(=O)C(NC(=O)C(NC(=O)C(CNC(=O)CC(N)CCCN)NC1=O)=CNC(N)=O)C2CCNC(=N2)N.O[S](O)(=O)=O",-7.669,8,13,9]
["S4236","Proflavine Hemisulfate","a4","L3900-43","in 10mM Water","Anti-infection,DNA/RNA Synthesis","Microbiology","Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.",258.25,"1811-28-5","<1","N/A",{"v":22,"d":"22.00"},85.19,"http://selleckchem.com/products/proflavine-hemisulfate.html","C13H11N3.1/2H2SO4","Sulfate","N/A","NC1=CC=C2C=C3C=CC(=CC3=NC2=C1)N.NC4=CC=C5C=C6C=CC(=CC6=NC5=C4)N.O[S](O)(=O)=O",3.113,2,4,0]
["S4254","Apramycin Sulfate","b4","L3900-43","in 10mM Water","Antibiotics","Microbiology","Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA.",637.66,"65710-07-8","<1","N/A",{"v":100,"d":"100.00"},156.82,"http://selleckchem.com/products/apramycin-sulfate.html","C21H41N5O11.xH2SO4","Sulfate","Ai3-29795","CNC1C(O)C2OC(OC3C(N)CC(N)C(O)C3O)C(N)CC2OC1OC4OC(CO)C(N)C(O)C4O.O[S](O)(=O)=O",{"v":-7.63,"d":"-7.630"},5,11,6]
["S4271","Isepamicin Sulphate","c4","L3900-43","in 10mM Water","Antibiotics,Bacterial","Microbiology","Isepamicin Sulphate (Isepamicine, Isepamycin, sch21420) is an aminoglycoside antibiotic, which inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit.",667.68,"67814-76-0","<1","N/A",{"v":100,"d":"100.00"},149.77,"http://selleckchem.com/products/isepamicin-sulphate.html","C22H45N5O16S","free base","Isepamicine (Isepamycin, sch21420) Sulphate","CNC1C(O)C(OCC1(C)O)OC2C(O)C(OC3OC(CN)C(O)C(O)C3O)C(N)CC2NC(=O)C(O)CN.O[S](O)(=O)=O",-7.948,5,11,9]
["S4287","Micafungin (FK 463) Sodium","d4","L3900-43","in 10mM Water","Fungal","Microbiology","Micafungin Sodium (FK463, Mycamine) is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.",1292.26,"208538-73-2","N/A","N/A",{"v":100,"d":"100.00"},77.38,"http://selleckchem.com/products/micafungin-sodium.html","C56H70N9NaO23S","Sodium Salt","Mycamine Sodium","CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(O)C(O)NC(=O)C5C(O)C(C)CN5C(=O)C(NC(=O)C(NC(=O)C6CC(O)CN6C(=O)C(NC4=O)C(C)O)C(O)C(O)C7=CC(=C(O)C=C7)O[S](=O)(=O)O[Na])C(O)CC(N)=O",-2.974,13,15,19]
["S4298","Amifostine trihydrate","e4","L3900-43","in 10mM Water","Others","Others","Amifostine trihydrate(WR2721 trihydrate) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.",268.27,"112901-68-5","<1","N/A",{"v":42,"d":"42.00"},156.56,"http://selleckchem.com/products/amifostine.html","C5H15N2O3PS.3H2O","trihydrate","WR2721 trihydrate","O.O.O.NCCCNCCS[P](O)(O)=O",-1.471,0,2,7]
["S4314","Ceftazidime Pentahydrate","f4","L3900-43","in 10mM Water","Others","Others","Ceftazidime is a β-lactam antibacterial agent which has demonstrated a broad spectrum of activity against Gram-positive and Gram-negative aerobic bacteria.",636.65,"78439-06-2",{"v":4,"d":"4.00"},6.28,{"v":100,"d":"100.00"},157.07,"http://www.selleckchem.com/products/ceftazidime-pentahydrate.html","C22H32N6O12S2","Pentahydrate","O.O.O.O.O.[H][C@]12SCC(C[N+]3=CC=CC=C3)=C(N1C(=O)[C@H]2NC(=O)C(=N\\OC(C)(C)C(O)=O)\\C1=CSC(N)=N1)C([O-])=O |r, c:8, 10, 12, 36, t:6, 32|","O.O.O.O.O.CC(C)(O/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C([O-])=O)C[N+]3=CC=CC=C3)C4=CSC(=N4)N)C(O)=O",{"v":6,"d":"6.000"},2,9]
["S4392","Potassium Canrenoate","g4","L3900-43","in 10mM Water","Others","Others","N/A",396.56,"2181-04-6","N/A","N/A",{"v":40,"d":"40.00"},100.87,"http://selleckchem.com/products/potassium-canrenoate.html","C22H29KO4","Potassium salt","Canrenoic Acid Potassium Salt","[K+].CC12CCC(=O)C=C1C=CC3C2CCC4(C)C3CCC4(O)CCC([O-])=O","N/A","N/A","N/A","N/A"]
["S4430","Hydroxychloroquine Sulfate (NSC 4375)","h4","L3900-43","in 10mM Water","Anti-infection,Autophagy,COVID-19,TLR","Autophagy","Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.",433.95,"747-36-4","<1","N/A",{"v":67,"d":"67.00"},{"v":154.4,"d":"154.40"},"http://selleckchem.com/products/hydroxychloroquine-sulfate.html","C18H28ClN3O5S","Sulfate","HCQ","CCN(CCO)CCCC(C)NC1=CC=NC2=CC(=CC=C12)Cl.O[S](O)(=O)=O",{"v":2.85,"d":"2.850"},1,2,9]
["S4540","Sisomicin sulfate","a5","L3900-43","in 10mM Water","Antibiotics","Microbiology","Sisomicin sulfate is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora.",1385.45,"53179-09-2","<1","N/A",{"v":100,"d":"100.00"},72.18,"http://selleckchem.com/products/sisomicin-sulfate.html","2C19H37N5O7.5H2SO4","Sulfate","N/A","CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(=CCC3N)CN)C2O.CNC4C(O)C(OCC4(C)O)OC5C(N)CC(N)C(OC6OC(=CCC6N)CN)C5O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-12.405,8,14,12]
["S4567","Eprodisate disodium","b5","L3900-43","in 10mM Water","Others","Neuronal Signaling","Eprodisate Disodium (NC-503) is the orally available disodium salt form of Eprodisate, a small-molecule, orally bioavailable, inhibitor of AA-amyloid fibrillogenesis.",248.19,"36589-58-9","<1","N/A",{"v":49,"d":"49.00"},197.43,"http://selleckchem.com/products/eprodisate-disodium.html","C3H8O6S2.2Na","sodium","NC-503","[Na+].[Na+].[O-][S](=O)(=O)CCC[S]([O-])(=O)=O",-5.437,0,0,4]
["S4575","Pralidoxime chloride","c5","L3900-43","in 10mM Water","AChR","Neuronal Signaling","Pralidoxime chloride (2-PAM) is an antidote to organophosphate pesticides and chemicals; An acetylcholinesterase (AChE) reactivator.",172.61,"51-15-0","<1","N/A",{"v":34,"d":"34.00"},196.98,"http://selleckchem.com/products/pralidoxime-chloride.html","C7H9N2O.Cl","chloride","2-PAM (chloride)","[Cl-].C[N+]1=C(C=CC=C1)\\C=N\\O",-1.122,1,0,1]
["S4582","Eflornithine (MDL-71782) hydrochloride hydrate","d5","L3900-43","in 10mM Water","Decarboxylase","Metabolism","Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.",236.64,"96020-91-6","<1","N/A",{"v":47,"d":"47.00"},198.61,"http://selleckchem.com/products/eflornithine-hydrochloride-hydrate.html","C6H12F2N2O2.HCl.H2O","hydrochloride hydrate","Difluoromethylornithine hydrochloride hydrate, DFMO hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate","O.Cl.NCCCC(N)(C(F)F)C(O)=O",-3.046,1,2,5]
["S4606","Glutathione","e5","L3900-43","in 10mM Water","Glutathione","Metabolism","Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.",307.32,"70-18-8","<1","N/A",{"v":61,"d":"61.00"},198.49,"http://selleckchem.com/products/glutathione.html","C10H17N3O6S","free base","Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine","NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O",-4.772,4,3,9]
["S4653","L-Ornithine hydrochloride","f5","L3900-43","in 10mM Water","Others","Others","L-ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.",168.62,"3184-13-2","<1","N/A",{"v":26,"d":"26.00"},196.73,"https://www.selleckchem.com/products/l-ornithine-hydrochloride.html","C5H13ClN2O2","free base","(S)-2,5-Diaminopentanoic acid","Cl.NCCCC(N)C(O)=O",-3.697,1,2,4]
["S4671","Cefradine","g5","L3900-43","in 10mM Water","Antibiotics","Microbiology","Cefradine (Cephradine, Sefril, Anspor, Velosef) is a semi-synthetic cephalosporin antibiotic.",{"v":349.4,"d":"349.40"},"38821-53-3","<1","N/A",{"v":10,"d":"10.00"},28.62,"http://selleckchem.com/products/cefradine.html","C16H19N3O4S","free base","Cephradine, Sefril, Anspor, Cephradin, Velosef","CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CCC=CC3)C2=O)C(O)=O",-2.277,3,2,4]
["S4702","Sarcosine","h5","L3900-43","in 10mM Water","Amino acid transporter,GlyT,NMDAR","Neuronal Signaling","Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.",89.09,"107-97-1","<1","N/A",{"v":17,"d":"17.00"},190.82,"http://selleckchem.com/products/sarcosine.html","C3H7NO2","free base","N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine","CNCC(O)=O",-3.439,1,1,2]
["S4770","Creatine phosphate disodium salt","a6","L3900-43","in 10mM Water","Others","Others","Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated creatine molecule that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle and the brain to recycle adenosine triphosphate, the energy currency of the cell.",255.08,"922-32-7","<1","N/A",{"v":51,"d":"51.00"},199.94,"http://selleckchem.com/products/creatine-phosphate-disodium-salt.html","C4H8N3O5P.2Na","disodium salt","Phosphocreatine disodium salt","[Na+].[Na+].CN(CC(O)=O)C(=N)N[P]([O-])([O-])=O",{"v":0,"d":"0.000"},0,0,0]
["S4827","Manganese chloride","b6","L3900-43","in 10mM Water","Others","Others","Manganese chloride occurs in nature as the mineral. It is used as a precursor for other manganese compounds.",125.84,"7773-01-5","N/A","N/A",{"v":100,"d":"100.00"},794.66,"http://selleckchem.com/products/manganese-chloride.html","MnCl2","free base","N/A","Cl[Mn]Cl",0.971,0,0,0]
["S4972","Choline Glycerophosphate","c6","L3900-43","in 10mM Water","Others","Others","Choline Glycerophosphate (Glycerophosphorylcholine) is a choline derivative and one of the two major forms of choline storage (along with phosphocholine) in the cytosol.",257.22,"28319-77-9",{"v":2,"d":"2.00"},7.78,{"v":51,"d":"51.00"},198.27,"http://selleckchem.com/products/choline-glycerophosphate.html","C8H20NO6P","Free Base","Glycerophosphorylcholine","C[N+](C)(C)CCO[P]([O-])(=O)OCC(O)CO",-4.131,2,2,8]
["S5048","Fosfomycin Disodium","d6","L3900-43","in 10mM Water","Antibiotics,Bacterial","Microbiology","Fosfomycin (Phosphonemycin) is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.",182.02,"26016-99-9","<1","N/A",{"v":36,"d":"36.00"},197.78,"http://selleckchem.com/products/fosfomycin-disodium.html","C3H5O4P.2Na","sodium","Phosphonemycin Disodium","[Na+].[Na+].CC1OC1[P]([O-])([O-])=O",-2.496,1,0,1]
["S5097","Methotrexate disodium","e6","L3900-43","in 10mM Water","Dehydrogenase,DHFR","Metabolism","Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.",{"v":498.4,"d":"498.40"},"7413-34-5","<1","N/A",{"v":99,"d":"99.00"},198.64,"http://selleckchem.com/products/methotrexate-disodium.html","C20H20N8O5.2Na","disodium salt","N/A","[Na+].[Na+].CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O",-2.834,5,3,9]
["S5131","Homotaurine","f6","L3900-43","in 10mM Water","GABA Receptor","Neuronal Signaling","Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.",139.17,"3687-18-1","N/A","N/A",{"v":27,"d":"27.00"},194.01,"http://selleckchem.com/products/homotaurine.html","C3H9NO3S","free base","Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid","NCCC[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S5136","Calcium folinate","g6","L3900-43","in 10mM Water","DHFR","Metabolism","Calcium folinate (Leucovorin calcium, Folinic acid calcium salt, Wellcovorin) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.",{"v":511.5,"d":"511.50"},"1492-18-8","<1","N/A",{"v":100,"d":"100.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/calcium-folinate.html","C20H21N7O7.Ca","calcium salt","Leucovorin calcium, Folinic acid calcium salt, Wellcovorin","[Ca++].NC1=NC(=C2N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)CNC2=N1)O",{"v":0,"d":"0.000"},0,0,0]
["S5220","D-Pantethine","h6","L3900-43","in 10mM Water","Vitamin","Metabolism","Pantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin) is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine and used as a dietary supplement for lowering blood cholesterol and triglycerides.",554.72,"16816-67-4","<1","N/A",{"v":100,"d":"100.00"},180.27,"http://selleckchem.com/products/d-pantethine.html","C22H42N4O8S2","free base","Bis-pantethine, Pantetina, Pantomin, Pantosin","CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO",-1.938,4,8,19]
["S5226","L-carnosine","a7","L3900-43","in 10mM Water","Others","Others","L-carnosine (Karnozin) is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress.",226.23,"305-84-0","<1","N/A",{"v":45,"d":"45.00"},198.91,"http://selleckchem.com/products/l-carnosine.html","C9H14N4O3","free base","Karnozin","NCCC(=O)NC(CC1=C[NH]C=N1)C(O)=O",-4.268,3,3,6]
["S5252","Ozagrel sodium","b7","L3900-43","in 10mM Water","P450 (e.g. CYP17),Prostaglandin Receptor","Metabolism","Ozagrel sodium (KCT-0809, Cataclot, Xanbo) is a thromboxane A2 synthase (CYP5) inhibitor with neuroprotective properties.",250.23,"189224-26-8",{"v":1,"d":"1.00"},{"v":4,"d":"4.00"},{"v":50,"d":"50.00"},199.82,"http://selleckchem.com/products/ozagrel-sodium.html","C13H11N2O2.Na","sodium","KCT-0809, Cataclot, Xanbo","[Na+].[O-]C(=O)\\C=C\\C1=CC=C(C[N]2C=CN=C2)C=C1",{"v":0.13,"d":"0.130"},1,0,4]
["S5296","Cephradine monohydrate","c7","L3900-43","in 10mM Water","Antibiotics,Bacterial","Microbiology","Cefradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.",367.42,"75975-70-1","<1","N/A",{"v":4,"d":"4.00"},10.89,"http://selleckchem.com/products/cephradine-monohydrate.html","C16H19N3O4S.H2O","hydrate","N/A","O.CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CCC=CC3)C2=O)C(O)=O",-2.484,3,2,4]
["S5384","UTP Trisodium Salt","d7","L3900-43","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.",550.09,"19817-92-6","<1","N/A",{"v":100,"d":"100.00"},181.79,"http://selleckchem.com/products/utp-trisodium-salt.html","C9H15N2O15P3.3Na","Trisodium salt","N/A","[Na+].[Na+].[Na+].OC1C(O)C(OC1CO[P]([O-])(=O)O[P]([O-])(=O)O[P](O)([O-])=O)N2C=CC(=O)NC2=O",-7.518,6,3,8]
["S5412","Loxoprofen Sodium","e7","L3900-43","in 10mM Water","Immunology & Inflammation related","Immunology & Inflammation","Loxoprofen sodium is a non-steroidal anti-inflammatory drug.",268.28,"80382-23-6","<1","N/A",{"v":53,"d":"53.00"},197.55,"https://www.selleckchem.com/products/loxoprofen-sodium.html","C15H17O3.Na","sodium salt","N/A","[Na+].CC(C([O-])=O)C1=CC=C(CC2CCCC2=O)C=C1",1.462,1,0,4]
["S5524","Spermine Tetrahydrochloride","f7","L3900-43","in 10mM Water","Others","Others","Spermine (Gerontine, Neuridine, Musculamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.",348.18,"306-67-2","<1","N/A",{"v":69,"d":"69.00"},198.17,"http://selleckchem.com/products/spermine-tetrahydrochloride.html","C10H26N4.4HCl","tetrahydrochloride","Gerontine tetrahydrochloride, Neuridine tetrahydrochloride, Musculamine tetrahydrochloride","Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN",0.024,0,4,11]
["S5533","Tobramycin sulfate","g7","L3900-43","in 10mM Water","Antibiotics,Bacterial","Microbiology","Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity.",1425.42,"49842-07-1","<1","N/A",{"v":100,"d":"100.00"},70.15,"https://www.selleckchem.com/products/tobramycin-sulfate.html","C36H84N10O38S5","free base","N/A","NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O.NCC4OC(OC5C(N)CC(N)C(OC6OC(CO)C(O)C(N)C6O)C5O)C(N)CC4O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",-16.755,8,20,12]
["S5588","Creatine","h7","L3900-43","in 10mM Water","IFN,JAK","JAK/STAT","Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.",131.13,"57-00-1","<1","N/A",{"v":26,"d":"26.00"},198.28,"http://selleckchem.com/products/creatine.html","C4H9N3O2","free base","Methylguanidoacetic acid","CN(CC(O)=O)C(N)=N",-1.095,1,1,3]
["S5591","Ectoine","a8","L3900-43","in 10mM Water","Others","Others","Ectoine ( THP(B)) is a natural amino acid derivate with membrane stabilizing and inflammation reducing capacities. It is produced by bacteria living under extreme harsh environmental conditions where it serves as osmoregulatory compatible solute.",142.16,"96702-03-3","<1","N/A",{"v":28,"d":"28.00"},196.97,"https://www.selleckchem.com/products/ectoine.html","C6H10N2O2","free base","THP(B)","CC1=NC(CCN1)C(O)=O",-0.868,2,1,1]
["S5631","L-Alanine","b8","L3900-43","in 10mM Water","Others","Others","Alanine is a naturally occuring non-essential amino acid that is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brainR, and the CNS.",89.09,"56-41-7","<1","N/A",{"v":17,"d":"17.00"},190.82,"http://selleckchem.com/products/l-alanine.html","C3H7NO2","free base","N/A","CC(N)C(O)=O",-3.161,1,1,1]
["S5634","L-arginine","c8","L3900-43","in 10mM Water","Others","Others","Arginine is an important amino acid used in the biosynthesis of proteins. L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. It is also implicated in cell division, wound healing and the release of hormones.",{"v":174.2,"d":"174.20"},"74-79-3","<1","N/A",{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-arginine.html","C6H14N4O2","free base","N/A","NC(CCCNC(N)=N)C(O)=O",-3.831,1,3,6]
["S5635","L-cysteine","d8","L3900-43","in 10mM Water","Others","Others","Cysteine is a naturally occurring, sulfur-containing amino acid which is important for protein synthesis, detoxification, and also exerts diverse metabolic functions.",121.16,"52-90-4","<1","N/A",{"v":24,"d":"24.00"},198.09,"http://selleckchem.com/products/l-cysteine.html","C3H7NO2S","free base","N/A","NC(CS)C(O)=O",-3.078,1,1,2]
["S5660","Clodronate disodium tetrahydrate","e8","L3900-43","in 10mM Water","Others","Others","Clodronate disodium tetrahydrate (clodronic acid) is a diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.",360.92,"88416-50-6","<1","N/A",{"v":72,"d":"72.00"},199.49,"https://www.selleckchem.com/products/clodronate-disodium-tetrahydrate.html","CH10Cl2Na2O10P2","free base","clodronic acid disodium tetrahydrate","O.O.O.O.[Na+].[Na+].O[P]([O-])(=O)C(Cl)(Cl)[P](O)([O-])=O",-2.534,0,0,2]
["S5721","Edetate calcium disodium","f8","L3900-43","in 10mM Water","Others","Others","Edetate (EDTA) calcium disodium is a chelating agent that is primarily used for the management of severe lead poisoning.",374.27,"62-33-9","<1","N/A",{"v":75,"d":"75.00"},200.39,"http://www.selleckchem.com/products/edetate-calcium-disodium.html","C10H12CaN2Na2O8","disodium salt","EDTA calcium disodium","[Na+].[Na+].[Ca++].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O",-7.512,0,0,11]
["S5801","Ala-Gln","g8","L3900-43","in 10mM Water","Others","Others","Ala-Gln (l-alanyl-l-glutamine), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln).",217.22,"39537-23-0","<1","N/A",{"v":43,"d":"43.00"},197.96,"http://www.selleckchem.com/products/ala-gln.html","C8H15N3O4","Free Base","l-alanyl-l-glutamine","CC(N)C(=O)NC(CCC(N)=O)C(O)=O",-4.543,3,3,6]
["S6023","Creatine monohydrate","h8","L3900-43","in 10mM Water","Others","Others","Creatine (Methylguanidoacetic acid) is a key player in the phosphagen energy system, the primary source of ATP during short-term, high intensity activities.",149.15,"6020-87-7","N/A","N/A",5.96,39.94,"http://www.selleck.cn/products/creatine-monohydrate.html","C4H11N3O3","monohydrate","Methylguanidoacetic acid monohydrate","O.CN(CC(O)=O)C(N)=N",-1.302,1,1,3]
["S6129","Aminomalonic acid","a9","L3900-43","in 10mM Water","Others","Others","Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite.",119.08,"1068-84-4","N/A","N/A",{"v":11,"d":"11.00"},92.37,"http://www.selleck.cn/products/aminomalonic-acid.html","C3H5NO4","free base","Aminomalonate, Aminopropanedioic acid","NC(C(O)=O)C(O)=O",-3.815,2,1,2]
["S6176","Scyllo-Inositol","b9","L3900-43","in 10mM Water","Others","Others","Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol) is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm.",180.16,"488-59-5","N/A","N/A",9.03,50.11,"http://www.selleck.cn/products/scyllo-inositol.html","C6H12O6","free base","Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol","OC1C(O)C(O)C(O)C(O)C1O",-3.065,0,6,0]
["S6460","Sugammadex (sodium)","c9","L3900-43","in 10mM Water","Others","Others","Sugammadex (ORG-25969) is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults.",2178.01,"343306-79-6","<1","N/A",{"v":100,"d":"100.00"},45.91,"http://www.selleck.cn/products/sugammadex.html","C72H104Na8O48S8","sodium","ORG-25969","[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OC1C(O)C2OC3OC(CSCCC([O-])=O)C(OC4OC(CSCCC([O-])=O)C(OC5OC(CSCCC([O-])=O)C(OC6OC(CSCCC([O-])=O)C(OC7OC(CSCCC([O-])=O)C(OC8OC(CSCCC([O-])=O)C(OC9OC(CSCCC([O-])=O)C(OC1OC2CSCCC([O-])=O)C(O)C9O)C(O)C8O)C(O)C7O)C(O)C6O)C(O)C5O)C(O)C4O)C(O)C3O",-18.704,16,16,40]
["S6488","Gadoxetate sodium","d9","L3900-43","in 10mM Water","Others","Others","Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection.",725.71,"135326-22-6","N/A","N/A",{"v":100,"d":"100.00"},{"v":137.8,"d":"137.80"},"http://www.selleck.cn/products/gadoxetate-sodium.html","C23H28GdN3Na2O11","sodium","N/A","[Na+].[Na+].[Gd+3]|1|2|3|4|5|6|7|[O-]C(=O)CN|1(CCN|2(CC([O-]|3)=O)CC([O-]|4)=O)CC(CC8=CC=C(OCC)C=C8)N|5(CC([O-]|6)=O)CC([O-]|7)=O",{"v":-3.48,"d":"-3.480"},1,0,4]
["S6592","Diquafosol Tetrasodium","e9","L3900-43","in 10mM Water","P2 Receptor","Neuronal Signaling","Diquafosol Tetrasodium (INS-365), a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease.",878.23,"211427-08-6","N/A","N/A",{"v":100,"d":"100.00"},113.87,"http://www.selleck.cn/products/diquafosol-tetrasodium.html","C18H22N4Na4O23P4","Tetrasodium","INS-365","[Na+].[Na+].[Na+].[Na+].OC1C(O)C(OC1CO[P]([O-])(=O)O[P]([O-])(=O)O[P]([O-])(=O)O[P]([O-])(=O)OCC2OC(C(O)C2O)N3C=CC(=O)NC3=O)N4C=CC(=O)NC4=O",-11.332,11,6,14]
["S7204","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","f9","L3900-43","in 10mM Water","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.",440.29,"168555-66-6","<1","N/A",{"v":28,"d":"28.00"},63.59,"http://selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html","C18H19O8P.2Na","Disodium salt","CA 4DP","[Na+].[Na+].COC1=C(O[P]([O-])([O-])=O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",1.077,5,0,8]
["S7537","LB-100","g9","L3900-43","in 10mM Water","PP2A","PI3K/Akt/mTOR","LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.",268.31,"1026680-07-8","<1","N/A",{"v":53,"d":"53.00"},197.53,"http://selleckchem.com/products/lb-100.html","C13H20N2O4","free base","N/A","CN1CCN(CC1)C(=O)C2C3CCC(O3)C2C(O)=O",-3.624,3,0,2]
["S7547","XL413 (BMS-863233)","h9","L3900-43","in 10mM Water","CDK","Cell Cycle","XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.",326.18,"1169562-71-3","<1","N/A",{"v":46,"d":"46.00"},141.03,"http://selleckchem.com/products/xl413-bms-863233.html","C14H13Cl2N3O2","free base","N/A","Cl.ClC1=CC2=C(OC3=C2N=C(NC3=O)C4CCCN4)C=C1",2.537,3,2,1]
["S7548","Rilmenidine Phosphate","a10","L3900-43","in 10mM Water","Imidazoline Receptor","GPCR & G Protein","Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used for the treatment of hypertension.",278.24,"85409-38-7",{"v":1,"d":"1.00"},3.59,{"v":55,"d":"55.00"},197.67,"http://selleckchem.com/products/rilmenidine-phosphate.html","C10H19N2O5P","Phosphate","N/A","O[P](O)(O)=O.C1CN=C(NC(C2CC2)C3CC3)O1",1.296,2,1,4]
["S7785","Pemetrexed Disodium Hydrate","b10","L3900-43","in 10mM Water","Apoptosis related,Autophagy,DHFR","Metabolism","Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.",516.42,"357166-30-4","<1","N/A",{"v":100,"d":"100.00"},193.64,"http://selleckchem.com/products/pemetrexed-disodium-hydrate.html","C20H21N5O6.5/2H2O.2Na","Disodium Hydrate","LY-231514 Disodium Hydrate","NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O[Na])C(=O)O[Na])N1",{"v":2.06,"d":"2.060"},7,4,11]
["S8199","Ruxotemitide (LTX 315)","c10","L3900-43","in 10mM Water","Bcl-2","Apoptosis","Ruxotemitide (LTX 315, Oncopore) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.",1439.79,"1345407-05-7","N/A","N/A",{"v":100,"d":"100.00"},69.45,"http://selleckchem.com/products/ltx-315.html","C78H106N18O9","free base","Oncopore","NCCCCC(N)C(=O)NC(CCCCN)C(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC3=C[NH]C4=C3C=CC=C4)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC5=C[NH]C6=C5C=CC=C6)C(=O)NC(C(C7=CC=CC=C7)C8=CC=CC=C8)C(=O)NC(CCCCN)C(N)=O",3.102,9,18,46]
["S8442","TAK-659","d10","L3900-43","in 10mM Water","FLT3,Syk","Angiogenesis","TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.",380.85,"1952251-28-3","<1","N/A",{"v":4,"d":"4.00"},{"v":10.5,"d":"10.50"},"http://selleckchem.com/products/tak-659.html","C17H21FN6.HCl","hydrochloride","N/A","Cl.C[N]1C=C(C=N1)C2=C3C(=O)NCC3=C(F)C(=N2)NC4CCCCC4N",1.774,3,3,3]
["S8454","ATN-161 (Ac-PHSCN-NH2)","e10","L3900-43","in 10mM Water","Integrin","Cytoskeletal Signaling","ATN-161 (Ac-PHSCN-NH2) is  a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.",597.64,"262438-43-7","N/A","N/A",{"v":13,"d":"13.00"},21.75,"http://selleckchem.com/products/atn-161.html","C23H35N9O8S","free base","N/A","CC(=O)N1CCCC1C(=O)NC(CC2=C[NH]C=N2)C(=O)NC(CO)C(=O)NC(CS)C(=O)NC(CC(N)=O)C(N)=O",-5.261,8,8,15]
["S8501","Adaptavir (DAPTA)","f10","L3900-43","in 10mM Water","CCR","Immunology & Inflammation","Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.",856.88,"106362-34-9","N/A","N/A",{"v":100,"d":"100.00"},{"v":116.7,"d":"116.70"},"http://selleckchem.com/products/dapta.html","C35H56N10O15","free base","D-Ala-peptide T-amide, peptide T","CC(N)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(C(C)O)C(N)=O",-7.366,9,16,24]
["S8549","AUNP-12","g10","L3900-43","in 10mM Water","PD-1/PD-L1","Immunology & Inflammation","AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.",3261.55,"1353563-85-5","N/A","N/A",{"v":100,"d":"100.00"},30.66,"http://selleckchem.com/products/aunp-12.html","C142H226N40O48","free base","Aur-012, Aurigene-012, Aurigene NP-12","CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCC(O)=O)NN)C(=O)NC(CCC(N)=O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C)C(=O)C(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCNNC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C=O)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(N)CO)C(C)O)C(C)C)C(C)O",-25.604,36,47,115]
["S9367","Adenosine disodium triphosphate hydrate","h10","L3900-43","in 10mM Water","Others","Others","Adenosine disodium triphosphate hydrate(ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells., ,",551.14,"34369-07-8","N/A",{"v":0,"d":"0.00"},{"v":100,"d":"100.00"},181.44,"https://www.selleckchem.com/products/adenosine-disodium-triphosphate.html","C10H14N5Na2O13P3.xH2O","disodium triphosphate hydrate","ATP disodium","O[C@H]1([C@H](N2C3C(N=C2)=C(N)N=CN=3)O[C@H](CO[P](O[P](O[P](=O)(O)O)(=O)O)(=O)O)[C@@H](O)1).[Na].O",-5.474,7,3,8]
["P1004","Bivalirudin Trifluoroacetate","a11","L3900-43","in 10mM Water","N/A","Angiogenesis","Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.",2180.33,"128270-60-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/peptide/bivalirudin-trifluoroacetate.html","C98H138N24O33","Trifluoroacetate","D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH","CCC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C3CCCN3C(=O)C(N)CC4=CC=CC=C4)C(=O)N5CCCC5C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC(CC(C)C)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["P1011","Eptifibatide Acetate","b11","L3900-43","in 10mM Water","5-alpha Reductase","Angiogenesis","Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.",{"v":832.4,"d":"832.40"},"148031-34-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/eptifibatide-acetate.html","C35H49N11O9S2","Acetate","Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2","NC(=N)NCCCCC1NC(=O)CCSSCC(NC(=O)C2CCCN2C(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC(=O)C(CC(O)=O)NC(=O)CNC1=O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["P1017","Octreotide (SMS 201-995) acetate","c11","L3900-43","in 10mM Water","N/A","Neuronal Signaling","Octreotide (SMS 201-995) acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.","1019.28 (free base)","79517-01-4","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/octreotide-acetate.html","C49H66N10O10S2.xC2H4O2","Acetate","D-Phe-c[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol","CC(O)C(CO)NC(=O)C1CSSCC(NC(=O)C(N)CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=C[NH]C5=C4C=CC=C5)C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O)N1",{"v":0,"d":"0.000"},0,0,0]
["P1025","Atosiban Acetate","d11","L3900-43","in 10mM Water","N/A","Angiogenesis","Atosiban Acetate is a competitive oxytocin and vasopressin antagonist by exhibiting high affinity for both receptors. It is used to treat preterm labors.",{"v":994.2,"d":"994.20"},"90779-69-4","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/peptide/atosiban-acetate.html","C43H67N11O12S2","Acetate","c[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2","CCOC1=CC=C(CC2NC(=O)CCSSCC(NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(NC2=O)C(C)CC)C(C)O)C(=O)N3CCCC3C(=O)NC(CCCN)C(=O)NCC(N)=O)C=C1",{"v":0,"d":"0.000"},0,0,0]
["P1029","Oxytocin (Syntocinon)","e11","L3900-43","in 10mM Water","N/A","Angiogenesis","Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood.",{"v":1067.2,"d":"1067.20"},"50-56-6","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/Oxytocin-Acetate(Syntocinon).html","C45H70N12O14S2","Free Base","H-Cys(1)-Tyr-Ile-Gln-Asn-Cys(1)-Pro-Leu-Gly-NH2","CCC(C)C1NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(N)=O.CC(O)=O",{"v":0,"d":"0.000"},0,0,0]
["P1030","Salmon Calcitonin Acetate","f11","L3900-43","in 10mM Water","N/A","N/A","Salmon Calcitonin Acetate, which is more potent and longer lasting than human CT, has been used widely for the treatment of osteoporosis, paget's disease, hypercalcemic shock and chronic pain in terminal cancer patients.",3431.85,"47931-85-1","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/peptide/salmon-calcitonin-acetate.html","C145H240N44O48S2","Acetate","N/A","CC(C)CC(NNC(CCC(N)=O)C(=O)NC(C(C)O)C(=O)C(=O)C(CC1=CC=C(O)C=C1)NN2CCCC2C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N3CCCC3C(N)=O)C(=O)C(=O)C(CCCCN)NC(=O)C(CC4=CN=C[NH]4)NC(=O)C(CC(C)C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(NC(=O)C5CSSCC(N)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)N5)C(C)C",{"v":0,"d":"0.000"},0,0,0]
["P1034","Terlipressin Acetate","g11","L3900-43","in 10mM Water","5-alpha Reductase","Angiogenesis","Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.",1227.37,"14636-12-5","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/terlipressin-acetate.html","C52H74N16O15S2","Acetate","Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2(Cys4-Cys9)","NCCCCC(NC(=O)C1CCCN1C(=O)C2CSSCC(NC(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O","N/A","N/A","N/A","N/A"]
["P1039","Somatostatin Acetate","h11","L3900-43","in 10mM Water","5-alpha Reductase","Neuronal Signaling","Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.",1637.88,"38916-34-6",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},61.05,"http://www.selleck.cn/products/somatostatin-acetate.html","C76H104N18O19S2","Free Base","Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH(Cys3-Cys14)","CC(N)C(=O)NCC(=O)NC1CSSCC(NC(=O)C(CO)NC(=O)C(NC(=O)C(CC2=CC=CC=C2)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC1=O)C(C)O)C(C)O)C(O)=O.CC(O)=O",-8.729,16,21,26]
["P1049","GHRP-2","a2","L3900-44","in 10mM Water","N/A","N/A","GHRP-2 is a true hGH secretagogue. It is a synthetic agonist of ghrelin.",{"v":878,"d":"878.00"},"158861-67-7","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/GHRP-2-Acetate.html","C47H59N9O8","Free Base","N/A","CC(N)C(=O)NC(CC1=CC=C2C=CC=CC2=C1)C(=O)NC(CC3=C[NH]C4=C3C=CC=C4)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCCN)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["P1084","Desmopressin Acetate","b2","L3900-44","in 10mM Water","Vasopressin Receptor","GPCR & G Protein","Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).",1129.27,"62288-83-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/desmopressin-acetate-.html","C46H64N14O12S2.C2H4O2","Acetate","N/A","CC(O)=O.NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)C2CSSCCC(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O",{"v":0,"d":"0.000"},0,0,0]
["P1085","Angiotensin II human Acetate","c2","L3900-44","in 10mM Water","Angiotensin Receptor","GPCR & G Protein","Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.",1106.23,"68521-88-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/angiotensin-ii-human-acetate.html","C52H75N13O14","Acetate","N/A","CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC2=C[NH]C=N2)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(O)=O.CC(O)=O",{"v":0,"d":"0.000"},0,0,0]
["P1087","Carperitide Acetate","d2","L3900-44","in 10mM Water","Others","Others","Caperitide acetate is a synthetic analog of human atrial natriuretic peptide (ANP) containing 28 amino acids. It acts as an inhibitor of endothelin-1 secretion when stimulated by angiotensin II (Ang II), likely through a cGMP-dependent mechanism.It induces natriuresis, diuresis, and vasodilation, effectively reducing blood volume and easing cardiac strain. By suppressing the renin-angiotensin-aldosterone system (RAAS), it aids in preventing myocardial remodeling and fibrosis, thereby enhancing cardiac function and decreasing the incidence of postoperative atrial fibrillation, heart failure, and stroke. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.",3140.49,"1366000-58-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/carperitide-acetate.html","C129H207N45O41S3","free base","N/A","CCC(C)C1NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CSSCC(NC(=O)CNC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CO)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=CC=C(O)C=C4)C(O)=O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(N)CO.CC(O)=O",-19.837,32,46,75]
["S1671","(6-)ε-​Aminocaproic acid","e2","L3900-44","in 10mM Water","Others","Others","(6-)ε-​Aminocaproic acid is a derivative and analogue of the amino acid lysine.",131.17,"60-32-2","N/A","N/A",{"v":26,"d":"26.00"},198.22,"http://selleckchem.com/products/Aminocaproic-acid(Amicar).html","C6H13NO2","free base","N/A","NCCCCCC(O)=O",-2.164,1,1,5]
["S3076","Foscarnet Sodium","f2","L3900-44","in 10mM Water","Reverse Transcriptase","Microbiology","Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.",191.95,"63585-09-1","N/A","N/A",{"v":3,"d":"3.00"},15.63,"http://selleckchem.com/products/foscarnet-sodium.html","CNa3O5P","Sodium","Phosphonoformate","[Na+].[Na+].[Na+].[O-]C(=O)[P]([O-])([O-])=O",-4.033,0,0,1]
["S5865","Hyaluronic acid","g2","L3900-44","in 10mM Water","Others","Others","Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is widely used in skin care.","N/A","9004-61-9","N/A","N/A",{"v":5,"d":"5.00"},"N/A","http://www.selleckchem.com/products/hyaluronic-acid.html","N/A","Free Base","Hyaluronan, Hyaluronate","CC(=O)NC1C(O[*])C(O)C(CO)OC1OC2C(O)C(O)C(O[*])OC2C(O)=O",-2.747,7,5,7]
["S3948","Spermine","h2","L3900-44","in 10mM Water","Others","Others","Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.",202.34,"71-44-3","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://selleckchem.com/products/spermine.html","C10H26N4","free base","4,9-Diaza-1,12-dodecanediamine","NCCCNCCCCNCCCN",-1.504,0,4,11]
["S2433","DL-Buthionine-Sulfoximine","a3","L3900-44","in 10mM Water","Glutathione","Metabolism","DL-Buthionine-Sulfoximine (BSO, DL-Buthionine-(S,R)-sulfoximine) is an inhibitor of glutathione (GSH) synthesis.",222.31,"5072-26-4","<1","N/A",{"v":44,"d":"44.00"},197.92,"http://www.selleckchem.com/products/dl-buthionine-sulfoximine.html","C8H18N2O3S","Free Base","BSO, DL-Buthionine-(S,R)-sulfoximine","CCCC[S](=N)(=O)CCC(N)C(O)=O",{"v":-2.18,"d":"-2.180"},2,1,7]
["S2435","Sodium stibogluconate","b3","L3900-44","in 10mM Water","phosphatase","Metabolism","Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.",907.88,"16037-91-5","<1","N/A",{"v":20,"d":"20.00"},22.03,"http://www.selleckchem.com/products/sodium-stibogluconate.html","C12H35Na3O26Sb2","Sodium","SSG, Stibogluconate sodium, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001","O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].OCC(O)C1O[Sb]2(O)(OC1C(O2)C([O-])=O)O[Sb]34([O-])OC(C(O)CO)C(O3)C(O4)C([O-])=O",-8.931,7,4,8]
["S8670","Vipivotide tetraxetan (PSMA-617)","c3","L3900-44","in 10mM Water","Drug-Linker Conjugates for ADC","Others","Vipivotide tetraxetan (PSMA-617) is a chemically modified PSMA(prostate-specific membrane antigen) inhibitor with a Ki of 0.37 nM.",1042.14,"1702967-37-0",{"v":-1,"d":"-1.00"},-0.96,{"v":100,"d":"100.00"},95.96,"http://www.selleckchem.com/products/vipivotide-tetraxetan.html","C49H71N9O16","Free Base","N/A","OC(=O)CCC(NC(=O)NC(CCCCNC(=O)C(CC1=CC2=CC=CC=C2C=C1)NC(=O)C3CCC(CC3)CNC(=O)CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)C(O)=O",-11.549,10,5,27]
["S4933","Lithium carbonate","d3","L3900-44","in 10mM Water","Dopamine Receptor","Neuronal Signaling","Lithium carbonate (Li2CO3) is an inorganic compound that is valuable and effective agent in the treatment and prophylaxis of mood disorders, particularly bipolar disorder (BD). Lithium carbonate is able to alter D2 dopamine receptors response.",73.89,"554-13-2","N/A","N/A","N/A",{"v":10,"d":"10.00"},"https://www.selleckchem.com/products/lithium-carbonate.html","CLi2O3","Salt","Li2CO3","[LiH].[Li]OOC=O",-0.347,2,0,2]
["S9665","Motixafortide (BL-8040)","e3","L3900-44","in 10mM Water","Apoptosis related,Bcl-2,CDK,CXCR,ERK,MicroRNA","Immunology & Inflammation","Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.",2159.52,"664334-36-5",{"v":-1,"d":"-1.00"},-0.46,{"v":100,"d":"100.00"},46.31,"http://www.selleckchem.com/products/motixafortide-bl-8040-.html","C97H144FN33O19S2","free base","BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140","NCCCCC1NC(=O)C(CCCNC(N)=O)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CSSCC(NC(=O)C(CCCNC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C4CCCN4C(=O)C(CCCCN)NC1=O)C(=O)NC(CCCNC(N)=N)C(N)=O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C7=CC=C(F)C=C7",-3.895,17,30,53]
["P1088","Lanreotide acetate","f3","L3900-44","in 10mM Water","GHSR","Endocrinology & Hormones","Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate, an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.",1156.38,"2378114-72-6",{"v":-1,"d":"-1.00"},"N/A",{"v":23,"d":"23.00"},19.89,"https://www.selleckchem.com/products/lanreotide-acetate.html","C56H73N11O12S2","Acetate","Laromustine, Angiopeptin, BIM 23014, BIM 23014C, BM 23014, Dermopeptin, Ipstyl, ITM-014, ITM-014T, Somatulina, Somatuline, Lanreotidum","CC(C)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(C(C)O)C(N)=O)NC(=O)C(N)CC5=CC6=CC=CC=C6C=C5.CC(O)=O",-0.979,9,13,17]
["S3327","Disodium 5'-inosinate monohydrate","g3","L3900-44","in 10mM Water","Others","Others","Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite.",410.18,"352195-40-5","<1","N/A",{"v":82,"d":"82.00"},199.91,"https://www.selleckchem.com/products/disodium-5-inosinate-monohydrate.html","C10H13N4Na2O9P","Monohydrate","Inosine 5'-monophosphate disodium salt hydrate","O.[Na+].[Na+].OC1C(O)C(OC1CO[P]([O-])([O-])=O)[N]2C=NC3=C2N=CNC3=O",-4.705,5,3,4]
["S3346","1-Methylnicotinamide chloride","h3","L3900-44","in 10mM Water","Prostaglandin Receptor","GPCR & G Protein","1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.",172.61,"1005-24-9","<1","N/A",{"v":35,"d":"35.00"},202.77,"https://www.selleckchem.com/products/1-methylnicotinamide-chloride.html","C7H9ClN2O","Chloride","1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium chloride, Trigonellamide chloride","[Cl-].C[N+]1=CC=CC(=C1)C(N)=O",-2.237,1,1,1]
["S8414","PACAP 1-27","a4","L3900-44","in 10mM Water","cAMP","GPCR & G Protein","Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.",3147.61,"127317-03-7",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},31.77,"https://www.selleckchem.com/products/pacap-1-27.html","C142H224N40O39S","Free Base","N/A","CCC(C)C(NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=C[NH]1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=CC=C(O)C=C4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC5=CC=C(O)C=C5)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(N)=O",-14.801,31,44,107]
["S8415","PACAP 1-38","b4","L3900-44","in 10mM Water","cAMP","GPCR & G Protein","PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38) is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.",4534.26,"137061-48-4",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},22.05,"https://www.selleckchem.com/products/pacap-1-38.html","C203H331N63O53S","Free Base","Pituitary Adenylate Cyclase Activating Polypeptide 38","CCC(C)C(NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC1=CN=C[NH]1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=CC=C(O)C=C4)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)C(=O)C(CC5=CC=C(O)C=C5)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC6=CC=C(O)C=C6)NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NN)C(C)C)C(C)C",-21.727,44,66,164]
["P1201","LL37 (Human cathelicidin)","c4","L3900-44","in 10mM Water","Anti-infection","Immunology & Inflammation","LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.",4493.26,"154947-66-7",{"v":-1,"d":"-1.00"},"N/A",{"v":50,"d":"50.00"},11.13,"http://www.selleckchem.com/products/ll37-human.html","C205H340N60O53","Free Base","Ropocamptide","CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CC(C)C)NNC(CC(C)C)C=O)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCC(O)=O)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)C(=O)C(NNC(C(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CC(O)=O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)O)C(=O)NC(CCC(O)=O)C(=O)C(=O)C(CO)NO)C(C)CC",-23.142,44,57,171]
["S1314","Zoledronic acid (ZOL 446)","d4","L3900-44","in 10mM Water","Apoptosis related,Autophagy,Ras,Rho","Cell Cycle","Zoledronic acid (ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast), a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. Zoledronic acid (ZA) also induces autophagy.",272.09,"118072-93-8","<1","N/A",{"v":4,"d":"4.00"},{"v":14.7,"d":"14.70"},"http://www.selleckchem.com/products/Zoledronic-Acid.html","C5H10N2O7P2","Free Base","ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast","OC(C[N]1C=CN=C1)([P](O)(O)=O)[P](O)(O)=O",-1.209,1,0,4]
["S3497","Gadobutrol","e4","L3900-44","in 10mM Water","Others","Others","Gadobutrol (Gadovist, Gadavist,ZK 135079) is a non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is usedfor tissue contrast enhancement in magnetic resonance imaging (MRI).",604.71,"138071-82-6","<1","N/A",{"v":100,"d":"100.00"},165.37,"http://www.selleckchem.com/products/gadobutrol.html","C18H31GdN4O9","Free Base","Gadovist, Gadavist,ZK 135079","[Gd+3].OCC(O)C(CO)N1CCN(CCN(CCN(CC1)CC([O-])=O)CC([O-])=O)CC([O-])=O",-6.984,0,3,10]
["S4494","Methionine","f4","L3900-44","in 10mM Water","GABA Receptor","Neuronal Signaling","Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.",149.21,"348-67-4","<1","N/A",{"v":29,"d":"29.00"},194.36,"http://www.selleckchem.com/products/methionine.html","C5H11NO2S","Free Base","MRX-1024, D-Methionine","CSCCC(N)C(O)=O",-2.834,1,1,4]
["S4879","Tenofovir hydrate","g4","L3900-44","in 10mM Water","Antiviral,Reverse Transcriptase","Microbiology","Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.",305.23,"206184-49-8","<1","N/A",{"v":10,"d":"10.00"},32.76,"http://www.selleckchem.com/products/tenofovir-hydrate.html","C9H16N5O5P","Hydrate","GS-1278 hydrate","O.CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O",-0.979,4,1,5]
["S5022","Varenicline Hydrochloride","h4","L3900-44","in 10mM Water","AChR","Neuronal Signaling","Varenicline (CP 526555) Hydrochloride is a potent and selective inhibitor of nicotine acetylcholine receptor (nAChR) with Ki of 0.12 nM and 0.14 nM for α6β2 nAChR and α4β2 nAChR, respectively.",247.72,"230615-23-3","<1","N/A",{"v":50,"d":"50.00"},201.84,"http://www.selleckchem.com/products/varenicline-hydrochloride.html","C13H14ClN3","Hydrochloride","CP 526555 hydrochloride","Cl.C1NCC2CC1C3=CC4=NC=CN=C4C=C23",{"v":1.42,"d":"1.420"},2,1,0]
["S5260","ATP","a5","L3900-44","in 10mM Water","Immunology & Inflammation related","Immunology & Inflammation","ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.",507.18,"56-65-5","<1","N/A",{"v":100,"d":"100.00"},197.17,"http://www.selleckchem.com/products/atp.html","C10H16N5O13P3","Free Base","Adenosine-Triphosphate, Adenosine 5'-triphosphate","NC1=C2N=C[N](C3OC(CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)C(O)C3O)C2=NC=N1",-2.526,7,3,8]
["S5330","Amikacin Sulfate Salt","b5","L3900-44","in 10mM Water","Antibiotics,Bacterial","Microbiology","Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains.",683.68,"149022-22-0","<1","N/A",{"v":100,"d":"100.00"},146.27,"http://www.selleckchem.com/products/amikacin-sulfate-salt.html","C22H45N5O17S","Sulfate Salt","BAY 41-6551 sulfate","NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC3OC(CO)C(O)C(N)C3O.O[S](O)(=O)=O",-9.033,5,13,10]
["S5964","Gatifloxacin hydrochloride","c5","L3900-44","in 10mM Water","Topoisomerase","DNA Damage/DNA Repair","Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.",411.86,"121577-32-0",{"v":4,"d":"4.00"},9.71,{"v":20,"d":"20.00"},48.56,"http://www.selleckchem.com/products/gatifloxacin-hydrochloride.html","C19H23ClFN3O4","Hydrochloride","AM-1155 hydrochloride, CG5501 hydrochloride, BMS-206584 hydrochloride, PD135432 hydrochloride","Cl.COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CCNC(C)C3)F)C4CC4",-0.527,3,1,4]
["S9803","Elamipretide (MTP-131)","d5","L3900-44","in 10mM Water","Mitochondrial Metabolism,Peroxidases","Metabolism","Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.",639.79,"736992-21-5",{"v":-1,"d":"-1.00"},"N/A",{"v":100,"d":"100.00"},{"v":156.3,"d":"156.30"},"http://www.selleckchem.com/products/elamipretide-mtp-131.html","C32H49N9O5","Free Base","SS-31, D-Arg-Dmt-Lys-Phe-NH2","CC1=C(CC(NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(N)=O)C(=CC(=C1)O)C",0.416,4,9,20]
["S2967","XE991 dihydrochloride","e5","L3900-44","in 10mM Water","Potassium Channel","Transmembrane Transporters","XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.",449.37,"122955-13-9","<1",{"v":0,"d":"0.00"},{"v":90,"d":"90.00"},200.28,"http://www.selleckchem.com/products/xe991-dihydrochloride.html","C26H22Cl2N2O","Dihydrochloride","LS190926 dihydrochloride","Cl.Cl.O=C1C2=CC=CC=C2C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15",5.276,3,0,4]
["S7920","L-NMMA acetate","f5","L3900-44","in 10mM Water","NOS","Immunology & Inflammation","L-NMMA acetate (Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate,  L-NG-monomethyl Arginine acetate) is an acetate salt form of L-NMMA. L-NMMA is a nitric oxide synthase(NOS) inhibitor with an IC50 of 4.1 μM for nNOS.",248.28,"53308-83-1","<1",{"v":0,"d":"0.00"},{"v":50,"d":"50.00"},201.39,"http://www.selleckchem.com/products/l-nmma-acetate.html","C9H20N4O4","Acetate","Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate,  L-NG-monomethyl Arginine acetate,","CNC(=N)NCCCC(N)C(O)=O.CC(O)=O",-3.829,2,3,7]
["S9489","Sodium citrate","g5","L3900-44","in 10mM Water","Others","Others","Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) is the preferred anticoagulant.",258.07,"68-04-2","<1",{"v":0,"d":"0.00"},{"v":52,"d":"52.00"},{"v":201.5,"d":"201.50"},"N/A","C6H5Na3O7","Free Base","N/A","[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O",-5.741,0,0,5]
["S9820","Angiotensin (1-7)","h5","L3900-44","in 10mM Water","ACE,RAAS","Endocrinology & Hormones","Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.",{"v":899,"d":"899.00"},"51833-78-4","<1","N/A",{"v":50,"d":"50.00"},55.62,"http://www.selleckchem.com/products/angiotensin-1-7.html","C41H62N12O11","Free Base","Ang-(1-7), Angiotensin fragment 1-7","CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC2=CN=C[NH]2)C(=O)N3CCCC3C(O)=O",{"v":-3.96,"d":"-3.960"},10,10,25]
["S6289","Gentamicin","a6","L3900-44","in 10mM Water","Antiviral","Microbiology","Gentamicin, an aminoglycoside class of bactericidal antibiotic, is effective against gram-negative bacterial infections.",1390.71,"1403-66-3","<1","N/A",{"v":100,"d":"100.00"},71.91,"http://www.selleckchem.com/products/gentamicin.html","C60H123N15O21","free base","N/A","CNC(C)C1CCC(N)C(O1)OC2C(N)CC(N)C(OC3OCC(C)(O)C(NC)C3O)C2O.CNC4C(O)C(OCC4(C)O)OC5C(N)CC(N)C(OC6OC(CN)CCC6N)C5O.CNC7C(O)C(OCC7(C)O)OC8C(N)CC(N)C(OC9OC(CCC9N)C(C)N)C8O",-12.679,12,21,19]
["S6872","Merbromin","b6","L3900-44","in 10mM Water","3C-Like Protease,Bacterial","Proteases","Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro.",752.68,"129-16-8","<1","N/A",{"v":100,"d":"100.00"},132.86,"http://www.selleckchem.com/products/merbromin.html","C20H10Br2HgO6.2Na","free base","Mercurochrome, Merbromine, Mercurocol, Sodium mercurescein, Asceptichrome, Supercrome, Brocasept, Cinfacromin","[NaH].[NaH].O[Hg]C1=C(O)C(=CC2=C1OC3=CC(=C(Br)C=C3C24OC(=O)C5=C4C=CC=C5)O)Br",4.622,3,2,1]
["E0510","Cidofovir hydrate","c6","L3900-44","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cidofovir hydrate is a selective inhibitor of viral DNA synthesis through the selective inhibition of viral DNA polymerase.",315.22,"149394-66-1","<1","N/A",{"v":4,"d":"4.00"},12.69,"http://www.selleckchem.com/products/cidofovir-hydrate.html","C8H14N3O6P.2H2O","Dihydride","N/A","O.O.NC1=NC(=O)N(CC(CO)OC[P;v5](O)(O)=O)C=C1",{"v":-2.59,"d":"-2.590"},3,2,6]
["E0525","Colistin","d6","L3900-44","in 10mM Water","Anti-infection","Microbiology","Colistin(Polymyxin E), a cyclic polypeptide antibiotic synthesized by Bacillus polymyxa subspecies colistinus Koyama, exerts antimicrobial activity by targeting at the bacterial cell membrane.",1155.43,"1066-17-7","<1","N/A",{"v":100,"d":"100.00"},86.55,"http://www.selleckchem.com/products/colistimethate.html","C52H98N16O13","free base","Polymyxin E","NA","NA","NA","NA","NA"]
["E0532","Menotropin","e6","L3900-44","in 10mM Water","Estrogen/progestogen Receptor","Endocrinology & Hormones","Menotropin (Human Menopausal Gonadotrophin) is a hormonally active medication for the treatment of fertility disturbances, which are extracted from the urine of postmenopausal women.",142.24,"61489-71-2","<1","N/A",{"v":28,"d":"28.00"},196.85,"http://www.selleckchem.com/products/menotropin.html","C9H18O","free base","Human Menopausal Gonadotrophin","CC(C)(C)CCCCC=O",2.767,1,0,5]
["E2635","Bicinchoninic acid disodium salt","f6","L3900-44","in 10mM Water","Others","Others","Bicinchoninic acid disodium salt is used for determination of reducing sugar and protein though Copper.",{"v":390.3,"d":"390.30"},"979-88-4","<1","N/A",{"v":39,"d":"39.00"},99.92,"http://www.selleckchem.com/products/bicinchoninic-acid-disodium-salt.html","C20H12N2O4.2Na","disodium salt","N/A","[NaH].[NaH].OC(=O)C1=CC(=NC2=C1C=CC=C2)C3=NC4=C(C=CC=C4)C(=C3)C(O)=O",3.837,4,0,3]
["E2830","Cyclocreatine","g6","L3900-44","in 10mM Water","Others","Others","Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by preserving high levels of ATP.",143.14,"35404-50-3","<1","N/A",{"v":7,"d":"7.00"},{"v":48.9,"d":"48.90"},"http://www.selleckchem.com/products/cyclocreatine.html","C5H9N3O2","free base","N/A","NC1=NCCN1CC(O)=O",{"v":-1.07,"d":"-1.070"},2,1,2]
["P1137","Thymulin","h6","L3900-44","in 10mM Water","CCR,Interleukins","Immunology & Inflammation","Thymulin (FTS) is a neuroendocrine hormone with immunoregulatory actions, with anti-inflammatory potential by downregulating the release of inflammatory mediators, such as cytokines and chemokines, upregulating anti-inflammatory factors, such as interleukin (IL)-10, exerting molecular control via the regulation of transcription factors and mediators.",858.85,"63958-90-7","<1","N/A",{"v":100,"d":"100.00"},116.43,"http://www.selleckchem.com/products/thymulin.html","C33H54N12O15","free base","FTS","CC(NC(=O)C1CCC(=O)N1)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CC(N)=O)C(O)=O",-11.877,12,14,28]
["S3736","Fondaparinux Sodium (Org 31540)","a7","L3900-44","in 10mM Water","Factor Xa","Metabolism","Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa.",1728.08,"114870-03-0",{"v":1,"d":"1.00"},0.58,{"v":100,"d":"100.00"},57.87,"http://www.selleckchem.com/products/fondaparinux-sodium.html","C31H43N3O49S8.10Na","Sodium salt","Natural heparin pentasaccharide Sodium, Fondaparin sodium, SR-90107A","[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].COC1OC(CO[S]([O-])(=O)=O)C(OC2OC(C(OC3OC(CO[S]([O-])(=O)=O)C(OC4OC(C(OC5OC(CO[S]([O-])(=O)=O)C(O)C(O)C5N[S]([O-])(=O)=O)C(O)C4O)C([O-])=O)C(O[S]([O-])(=O)=O)C3N[S]([O-])(=O)=O)C(O)C2O[S]([O-])(=O)=O)C([O-])=O)C(O)C1N[S]([O-])(=O)=O",-32.806,15,9,30]
["S8416","PACAP 6-38","b7","L3900-44","in 10mM Water","cAMP","GPCR & G Protein","PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.",4024.74,"143748-18-9","<1","N/A",{"v":100,"d":"100.00"},24.85,"http://www.selleckchem.com/products/pacap-6-38.html","C182H300N56O45S","Free base","N/A","CSCCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(N)CC3=CC=CC=C3)C(C)O)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC4=CC=C(O)C=C4)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC5=CC=C(O)C=C5)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(N)=O",{"v":-15.97,"d":"-15.970"},37,59,146]
["S8505","LY2510924","c7","L3900-44","in 10mM Water","CXCR","Immunology & Inflammation","LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0.38 nmol/L.",1189.45,"1088715-84-7","<1","N/A",{"v":100,"d":"100.00"},84.07,"http://www.selleckchem.com/products/ly2510924.html","C62H88N14O10","Free base","N/A","CC(C)NCCCCC(NC(=O)C1CCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)NC(CCCCNC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=CC5=C(C=CC=C5)C=C4)C(=O)NCC(=O)N1)C(N)=O",1.764,9,14,26]
["S9725","Balixafortide (POL6326)","d7","L3900-44","in 10mM Water","CXCR","Immunology & Inflammation","Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.",1864.11,"1051366-32-5","<1","N/A",{"v":100,"d":"100.00"},53.64,"http://www.selleckchem.com/products/balixafortide-pol6326.html","C84H118N24O21S2","Free base","N/A","CC1NNC(CC2=CN=C[NH]2)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC7CSSCC(NC1=O)C(=O)NC(CO)C(=O)NC(C)C(=O)N8CCCC8C(=O)NC(CCN)C(=O)NC(CCCNC(N)=N)C(=O)C(=O)C(CC9=CC=C(O)C=C9)NC7=O",-6.059,18,23,23]
["E1223","RGX-202","e7","L3900-44","in 10mM Water","Apoptosis related","Metabolism","RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, RGX-202 also inhibits creatine import both in vitro and in vivo.",131.13,"353-09-3","<1","N/A",{"v":26,"d":"26.00"},198.28,"https://www.selleckchem.com/products/rgx-202.html","C4H9N3O2","Free base","N/A","NC(=N)NCCC(O)=O",-1.052,1,2,4]
["E2035","Larazotide","f7","L3900-44","in 10mM Water","Others","Others","Larazotide(AT-1001) is an antagonist of Zonulin, which appears safe and well-tolerated and may offer potential benefit as an adjuvant to immune-targeted therapies.",725.83,"258818-34-7","<1","N/A",{"v":25,"d":"25.00"},34.44,"http://www.selleckchem.com/products/larazotide.html","C32H55N9O10","Free base","AT-1001","CC(C)CC(NC(=O)C(NC(=O)CNC(=O)CN)C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NCC(O)=O",-5.496,9,8,21]
["P1019","Cetrorelix Acetate","g7","L3900-44","in 10mM Water","GNRH Receptor","Endocrinology & Hormones","Cetrorelix Acetate (NS 75A Acetate, SB 075 Acetate, SB 75 Acetate) is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH) with an IC50 of 1.21 nM.",1551.14,"130143-01-0","<1","N/A",{"v":100,"d":"100.00"},64.47,"http://www.selleckchem.com/peptide/cetrorelix-acetate.html","C70H92ClN17O14.2(C2H4O2)","Acetate","Ac-3-(2-naphthyl)-D-Ala-4-Chloro-D-Phe-3(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2","CC(C)CC(NC(=O)C(CCCNC(N)=O)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC2=CN=CC=C2)NC(=O)C(CC3=CC=C(Cl)C=C3)NC(=O)C(CC4=CC5=CC=CC=C5C=C4)NC(C)=O)C(=O)NC(CCCN=C(N)N)C(=O)N6CCCC6C(=O)NC(C)C(N)=O.CC(O)=O.CC(O)=O",{"v":-0.13,"d":"-0.130"},16,16,38]
["P1027","Melanotan II","h7","L3900-44","in 10mM Water","5-alpha Reductase","Angiogenesis","Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH).",{"v":1084.2,"d":"1084.20"},"121062-08-6","<1","N/A",{"v":100,"d":"100.00"},92.23,"http://www.selleckchem.com/peptide/Melanotan-II(Melanotan-2).html","C52H73N15O11","Free base","MT-II","CCCCC(NC(C)=O)C(=O)NC1CC(=O)NCCCCC(NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=C[NH]5)NC1=O)C(N)=O",-0.877,10,13,18]
["S6482","Fosphenytoin (disodium)","a8","L3900-44","in 10mM Water","Others","Others","Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration.",406.24,"92134-98-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleck.cn/products/fosphenytoin.html","C16H13N2Na2O6P","disodium","N/A","[Na+].[Na+].[O-][P]([O-])(=O)OCN1C(=O)NC(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3",-0.495,3,1,5]
["S5961","Prednisolone disodium phosphate","b8","L3900-44","in 10mM Water","Anti-infection","Microbiology","Prednisolone disodium phosphate (Hydeltrasol, Prednisolone 21-phosphate disodium) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties that exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells.",484.39,"125-02-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/products/prednisolone-disodium-phosphate.html","C21H27Na2O8P","Phosphate","Hydeltrasol, Prednisolone 21-phosphate disodium","[Na+].[Na+].CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO[P]([O-])([O-])=O",-0.989,3,1,4]
["E0178","Cysteamine bitartrate","c8","L3900-44","in 10mM Water","Others","Others","Cysteamine bitartrate (Mercaptamine bitartrate) is an FDA-approved cystine-depleting aminothiol agent for the treatment of nephropathic cystinosis to decrease accumulation of lysosomal cystine by engaging in disulfide exchange. In addition, cysteamine bitartrate has antioxidant properties.",227.24,"27761-19-9","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/products/cysteamine-bitartrate.html","C6H13NO6S","Bitartrate","Mercaptamine bitartrate","NCCS.OC(C(O)C(O)=O)C(O)=O",-4.359,2,3,4]
["P1148","BPC157","d8","L3900-44","in 10mM Water","Others","Others","BPC157 (Bepecin, PL 14736), a small, chemically synthesised pentadecapeptide and a partial sequence of the human gastric juice protein BPC, which has been shown to be safe in clinical trials for inflammatory bowel disease and may be able to cure intestinal anastomosis dehiscence.",1419.54,"137525-51-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleckchem.com/products/bpc157.html","C62H98N16O22","free base","Bepecin, PL 14736","CC(C)CC(NC(=O)CNC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C2CCCN2C(=O)C3CCCN3C(=O)C4CCCN4C(=O)C(CCC(O)=O)NC(=O)CN)C(=O)NC(C(C)C)C(O)=O",-11.745,18,12,39]
["E4258","L-Norleucine","e8","L3900-44","in 10mM Water","Endogenous Metabolite","Metabolism","L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.",131.17,"327-57-1","N/A","N/A","N/A",">10","https://www.selleckchem.com/products/l-norleucine.html","C6H13NO2","free base","L-Norleucine","CCCCC(N)C(O)=O",-1.725,1,1,4]
["E4111","Phytic acid (dodecasodium salt hydrate)","f8","L3900-44","in 10mM Water","Xanthine Oxidase","Metabolism","Phytic acid (dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. It is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue and inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.",957.87,"123408-98-0","N/A","N/A","N/A",">10","https://www.selleckchem.com/products/phytic-acid-dodecasodium-salt-hydrate.html","C6H6O24P6.H2O.12Na","dodecasodium salt","Inositol hexaphosphate dodecasodium hydrate","O.[Na;v0].O[P](O)(=O)OC1C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C1O[P](O)(O)=O",-3.701,6,0,12]
["E2759","L-(+)-Ergothioneine","g8","L3900-44","in 10mM Water","Others","Others","L-(+)-Ergothioneine(Ergothioneine), an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.",{"v":229.3,"d":"229.30"},"497-30-3","<1","N/A",{"v":46,"d":"46.00"},200.61,"https://www.selleckchem.com/products/l--ergothioneine.html","C9H15N3O2S","Free base","Ergothioneine","C[N+](C)(C)C(CC1=CNC(=S)N1)C([O-])=O",-2.967,0,2,4]
["E4018","Ammonium sulfate","h8","L3900-44","in 10mM Water","Others","Others","Ammonium sulphate (Mascagnite) is an inorganic sulfate salt used for the purification of enzymes and antibodies.",132.14,"7783-20-2","<1","N/A",{"v":23,"d":"23.00"},174.06,"https://www.selleckchem.com/products/ammonium-sulfate.html","H3N.1/2H2O4S","Ammonium","Mascagnite","N.O[S](O)(=O)=O",-0.918,0,0,0]
["E2895","Sodium Bicarbonate","a9","L3900-44","in 10mM Water","Others","Others","Sodium bicarbonate(Armex Blast Media Flow Formula XL, BI-CF 40E, BI-H 40E, Bakeshure 180, Sodium Hydrogen Carbonate, Sodium hydrogen carbonate) is a biochemical reagent used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.",85.01,"144-55-8","<1","N/A",{"v":25,"d":"25.00"},294.08,"https://www.selleckchem.com/products/sodium-bicarbonate.html","CH2O3.Na","Free base","Armex Blast Media Flow Formula XL, BI-CF 40E, BI-H 40E, Bakeshure 180, Sodium Hydrogen Carbonate, Sodium hydrogen carbonate","[Na;v0].OC(O)=O",0.213,0,0,0]
["E4470","Potassium Chloride","b9","L3900-44","in 10mM Water","Others","Others","Potassium chloride is an inorganic salt commonly used in fertilizer industry. It is also extensively used as a potassium supplement.",74.55,"7447-40-7","<1","N/A",{"v":100,"d":"100.00"},1341.38,"https://www.selleckchem.com/products/potassium-chloride.html","ClK","Potassium","N/A","Cl[K]",0.485,0,0,0]
["S2542","Phenformin (NSC-756501) HCl","c9","L3900-44","in 10mM Water","AMPK","PI3K/Akt/mTOR","Phenformin HCl (NSC-756501, Phenethylbiguanide) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.",241.72,"834-28-6","N/A","N/A","N/A",">10","http://selleckchem.com/products/Phenformin-hydrochloride.html","C10H15N5.HCl","Hydrochloride","Phenethylbiguanide HCl","Cl.NC(=N)NC(=N)NCCC1=CC=CC=C1",1.339,0,3,6]
["S1019","Canertinib (CI-1033)","a2","L3900-45","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Canertinib (CI-1033, PD183805) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.",485.94,"267243-28-7",{"v":2,"d":"2.00"},4.12,"<1","N/A","http://selleckchem.com/products/CI-1033(Canertinib).html","C24H25ClFN5O3","Free Base","PD183805","FC1=C(Cl)C=C(NC2=NC=NC3=CC(=C(NC(=O)C=C)C=C23)OCCCN4CCOCC4)C=C1",4.037,5,2,9]
["S1023","Erlotinib (OSI-774) HCl","b2","L3900-45","in 2mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781) HCl is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.",{"v":429.9,"d":"429.90"},"183319-69-9",{"v":4,"d":"4.00"},{"v":9.3,"d":"9.30"},"<1","N/A","http://selleckchem.com/products/Erlotinib-Hydrochloride.html","C22H23N3O4.HCl","Hydrochloride","CP358774, NSC 718781,OSI-774 HCl","Cl.COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.691,6,1,10]
["S1043","Tandutinib (MLN518)","c2","L3900-45","in 2mM DMSO","FLT3","Angiogenesis","Tandutinib (MLN518, CT53518, NSC726292) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.",{"v":562.7,"d":"562.70"},"387867-13-2",{"v":5,"d":"5.00"},8.89,"<1","N/A","http://selleckchem.com/products/Tandutinib-(MLN518).html","C31H42N6O4","Free Base","CT 53518, NSC726292, MLN518","COC1=CC2=C(C=C1OCCCN3CCCCC3)N=CN=C2N4CCN(CC4)C(=O)NC5=CC=C(OC(C)C)C=C5",4.674,6,1,10]
["S1046","Vandetanib (ZD6474)","d2","L3900-45","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1108","TAE684 (NVP-TAE684)","e2","L3900-45","in 2mM DMSO","ALK,Apoptosis related","Protein Tyrosine Kinase","TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.",{"v":614.2,"d":"614.20"},"761439-42-3",{"v":3,"d":"3.00"},4.88,"<1","N/A","http://selleckchem.com/products/NVP-TAE684.html","C30H40ClN7O3S","Free Base","N/A","COC1=C(NC2=NC=C(Cl)C(=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.342,5,2,9]
["S1112","SGX-523","f2","L3900-45","in 2mM DMSO","c-Met","Protein Tyrosine Kinase","SGX-523 is a selective Met (c-Met) inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. Phase 1.",359.41,"1022150-57-7",{"v":3,"d":"3.00"},8.35,"<1","N/A","http://selleckchem.com/products/SGX-523.html","C18H13N7S","free base","N/A","C[N]1C=C(C=N1)C2=N[N]3C(=NN=C3C=C2)SC4=CC=C5N=CC=CC5=C4",{"v":3.58,"d":"3.580"},5,0,3]
["S1205","PIK-75 HCl","g2","L3900-45","in 2mM DMSO","DNA-PK,PI3K","PI3K/Akt/mTOR","PIK-75 HCl is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.",488.74,"372196-77-5",{"v":4,"d":"4.00"},8.18,"<1","N/A","http://selleckchem.com/products/PIK-75-Hydrochloride.html","C16H14BrN5O4S.HCl","Hydrochloride","N/A","Cl.CN(/N=C/C1=CN=C2C=CC(=C[N]12)Br)[S](=O)(=O)C3=C(C)C=CC(=C3)[N+]([O-])=O",3.272,4,0,5]
["S1211","Imiquimod (R-837)","h2","L3900-45","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Imiquimod (Aldara,R-837,S-26308) is a novel synthetic agent with immune response modifying activity.",{"v":240.3,"d":"240.30"},"99011-02-6",{"v":1,"d":"1.00"},4.16,"<1","N/A","http://selleckchem.com/products/Imiquimod.html","C14H16N4","free base","Aldara,R-837, S-26308","CC(C)C[N]1C=NC2=C(N)N=C3C=CC=CC3=C12",2.722,2,1,2]
["S1288","Camptothecin (NSC-100880)","a3","L3900-45","in 2mM DMSO","ADC Cytotoxin,Apoptosis related,MicroRNA,Topoisomerase","DNA Damage/DNA Repair","Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.",348.35,"7689-03-4",{"v":3,"d":"3.00"},8.61,"<1","N/A","http://selleckchem.com/products/Camptothecine.html","C20H16N2O4","Free Base","CPT, Campathecin, (S)-(+)-Camptothecin","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=CC5=C4)C2=O",1.746,4,0,1]
["S1327","Ellagic acid","b3","L3900-45","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property.",302.19,"476-66-4",{"v":3,"d":"3.00"},9.93,"<1","N/A","http://selleckchem.com/products/Ellagic-acid.html","C14H6O8","free base","Elagostasine, Gallogen","OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S1353","Ketoconazole (R 41400)","c3","L3900-45","in 2mM DMSO","Androgen Receptor,Fungal,P450 (e.g. CYP17)","Metabolism","Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.",531.43,"65277-42-1",{"v":5,"d":"5.00"},9.41,"<1","N/A","http://selleckchem.com/products/Ketoconazole.html","C26H28Cl2N4O4","free base","R 41400","CC(=O)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=CN=C4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",{"v":3.61,"d":"3.610"},5,0,7]
["S1360","GSK1059615","d3","L3900-45","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Phase 1.",333.36,"958852-01-2",{"v":2,"d":"2.00"},{"v":6,"d":"6.00"},"<1","N/A","http://selleckchem.com/products/GSK1059615.html","C18H11N3O2S","Free Base","N/A","O=C1NC(=O)/C(S1)=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2",2.496,4,1,2]
["S1371","Cefoselis Sulfate","e3","L3900-45","in 2mM DMSO","Antibiotics","Microbiology","Cefoselis (FK 037 Sulfate) is a widely used beta-lactam antibiotic.",620.64,"122841-12-7",{"v":3,"d":"3.00"},4.83,{"v":5,"d":"5.00"},8.06,"http://selleckchem.com/products/Cefoselis-sulfate.html","C19H22N8O6S2.H2SO4","Sulfate","FK 037 Sulfate","CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)CN3C=CC(=N)N3CCO)C4=CSC(=N4)N.O[S](O)(=O)=O",-2.894,6,3,9]
["S1424","Prazosin HCl","f3","L3900-45","in 2mM DMSO","Adrenergic Receptor","GPCR & G Protein","Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.",419.86,"19237-84-4",{"v":4,"d":"4.00"},9.53,"<1","N/A","http://selleckchem.com/products/Prazosin-hydrochloride.html","C19H21N5O4.HCl","Hydrochloride","cp-12299-1","Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N",2.489,6,1,4]
["S1507","Irbesartan","g3","L3900-45","in 2mM DMSO","Angiotensin Receptor","GPCR & G Protein","Irbesartan (BMS-186295, SR-47436,APROVEL) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.",428.53,"138402-11-6",{"v":4,"d":"4.00"},9.33,"<1","N/A","http://selleckchem.com/products/Irbesartan(Avapro).html","C25H28N6O","free base","BMS-186295, SR-47436,APROVEL","CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5",{"v":0,"d":"0.000"},0,0,0]
["S1509","Norfloxacin","h3","L3900-45","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Norfloxacin (MK-0366) is a broad-spectrum antibiotic. Norfloxacin (MK-0366) targets bacterial gyrase and topoisomerase IV enzymes.",319.33,"70458-96-7",{"v":3,"d":"3.00"},9.39,"<1","N/A","http://selleckchem.com/products/Norfloxacin(Norxacin).html","C16H18FN3O3","free base","MK-0366","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(C=C12)N3CCNCC3)F",{"v":0,"d":"0.000"},0,0,0]
["S1519","CCT129202","a4","L3900-45","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.",497.02,"942947-93-5",{"v":3,"d":"3.00"},6.04,"<1","N/A","http://selleckchem.com/products/CCT129202.html","C23H25ClN8OS","Free Base","N/A","CN(C)C1=CC=C(C=C1)C2=NC3=C(N4CCN(CC4)CC(=O)NC5=NC=CS5)C(=CN=C3[NH]2)Cl",2.898,4,2,6]
["S1615","Risperidone","b4","L3900-45","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Risperidone (R-64766) is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder.",410.48,"106266-06-2",{"v":4,"d":"4.00"},9.74,"<1","N/A","http://selleckchem.com/products/Risperidone(Risperdal).html","C23H27FN4O2","free base","R-64766","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCCC5=N1",3.317,4,0,4]
["S1642","Methyldopa","c4","L3900-45","in 2mM DMSO","5-HT Receptor,Adrenergic Receptor,Decarboxylase,Dopamine Receptor","Metabolism","Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.",211.21,"555-30-6",{"v":2,"d":"2.00"},9.47,"<1","N/A","http://selleckchem.com/products/Methyldopa(Aldomet).html","C10H13NO4","free base","N/A","CC(N)(CC1=CC(=C(O)C=C1)O)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S1698","Torsemide","d4","L3900-45","in 2mM DMSO","Chloride Channel","Transmembrane Transporters","Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.",348.42,"56211-40-6",{"v":3,"d":"3.00"},8.61,"<1","N/A","http://selleckchem.com/products/Torsemide(Demadex).html","C16H20N4O3S","free base","AC-4464, JDL-464","CC(C)NC(=O)N[S](=O)(=O)C1=C(NC2=CC(=CC=C2)C)C=CN=C1",{"v":0,"d":"0.000"},0,0,0]
["S1707","Eplerenone (CGP 30083)","e4","L3900-45","in 2mM DMSO","Mineralocorticoid Receptor","Endocrinology & Hormones","Eplerenone (CGP 30083, SC-66110) is a mineralocorticoid receptor antagonist, and blocks the action of aldosterone, used to control high blood pressure.",414.49,"107724-20-9",{"v":4,"d":"4.00"},9.65,"<1","N/A","http://selleckchem.com/products/Eplerenone(Inspra).html","C24H30O6","free base","CGP 30083, SC-66110","COC(=O)C1CC2=CC(=O)CCC2(C)C34OC3CC5(C)C(CCC56CCC(=O)O6)C14",{"v":0,"d":"0.000"},0,0,0]
["S1724","Paliperidone","f4","L3900-45","in 2mM DMSO","Dopamine Receptor","Neuronal Signaling","Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.",426.48,"144598-75-4",{"v":4,"d":"4.00"},9.38,"<1","N/A","http://selleckchem.com/products/Paliperidone(Invega).html","C23H27FN4O3","free base","N/A","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCC(O)C5=N1",{"v":0,"d":"0.000"},0,0,0]
["S1851","Oxibendazole","g4","L3900-45","in 2mM DMSO","Parasite","Microbiology","Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.",249.27,"20559-55-1",{"v":1,"d":"1.00"},4.01,"<1","N/A","http://selleckchem.com/products/oxibendazole.html","C12H15N3O3","Free Base","N/A","CCCOC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",2.506,4,2,5]
["S1929","Irsogladine","h4","L3900-45","in 2mM DMSO","AChR,PDE","Metabolism","Irsogladine(Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.",256.09,"57381-26-7",{"v":2,"d":"2.00"},7.81,"<1","N/A","http://selleckchem.com/products/Irsogladine-maleate.html","C9H7Cl2N5","free base","Dicloguamine","NC1=NC(=NC(=N1)C2=C(Cl)C=CC(=C2)Cl)N",2.443,3,2,1]
["S1977","Sarafloxacin HCl","a5","L3900-45","in 2mM DMSO","Antibiotics","Microbiology","Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.",421.83,"91296-87-6",{"v":4,"d":"4.00"},9.48,"<1","N/A","http://selleckchem.com/products/sarafloxacin-hydrochloride.html","C20H17F2N3O3.HCl","Hydrochloride","A-56620 HCl","Cl.OC(=O)C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(=C3)N4CCNCC4)C1=O",{"v":0,"d":"0.000"},0,0,0]
["S1986","Meclizine 2HCl","b5","L3900-45","in 2mM DMSO","CAR,Histamine Receptor","Neuronal Signaling","Meclizine (NSC 28728,Meclozine dihydrochloride) is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.",463.87,"1104-22-9",{"v":4,"d":"4.00"},8.62,"<1","N/A","http://selleckchem.com/products/meclizine-dihydrochloride.html","C25H27Cl2N2.2HCl","Dihydrochloride","NSC 28728,Meclozine dihydrochloride","Cl.Cl.CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(Cl)C=C4",{"v":0,"d":"0.000"},0,0,0]
["S2035","Epalrestat (ONO-2235)","c5","L3900-45","in 2mM DMSO","Aldose Reductase,Carbohydrate Metabolism","Metabolism","Epalrestat (ONO-2235) is an aldose reductase inhibitor with IC50 of 72 nM.",{"v":319.4,"d":"319.40"},"82159-09-9",{"v":3,"d":"3.00"},9.39,"<1","N/A","http://selleckchem.com/products/epalrestat.html","C15H13NO3S2","free base","ONO-2235","CC(=C/C1=CC=CC=C1)\\C=C2/SC(=S)N(CC(O)=O)C2=O",3.442,2,0,4]
["S2047","Lornoxicam","d5","L3900-45","in 2mM DMSO","COX","Neuronal Signaling","Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.",371.82,"70374-39-9",{"v":3,"d":"3.00"},8.07,"<1","N/A","http://selleckchem.com/products/lornoxicam-xefo.html","C13H10ClN3O4S2","free base","Chlortenoxicam","CN1C(=C(O)C2=C(C=C(Cl)S2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.913,4,2,2]
["S2110","Vinpocetine","e5","L3900-45","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","Vinpocetine (RGH-4405,Ethyl apovincaminate,AY 27255) is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia  and Alzheimer's disease.",350.45,"42971-09-5",{"v":3,"d":"3.00"},8.56,"<1","N/A","http://selleckchem.com/products/vinpocetine-cavinton.html","C22H26N2O2","free base","RGH-4405,Ethyl apovincaminate,AY 27255","CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)[N]1C5=CC=CC=C45",{"v":0,"d":"0.000"},0,0,0]
["S2150","Neratinib (HKI-272)","f5","L3900-45","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.",557.04,"698387-09-6",{"v":5,"d":"5.00"},8.98,"<1","N/A","http://selleckchem.com/products/Neratinib(HKI-272).html","C30H29ClN6O3","free base","N/A","CCOC1=C(NC(=O)\\C=C\\CN(C)C)C=C2C(=C1)N=CC(=C2NC3=CC=C(OCC4=NC=CC=C4)C(=C3)Cl)C#N",4.881,5,2,11]
["S2152","Sitafloxacin Hydrate","g5","L3900-45","in 2mM DMSO","Antibiotics","Microbiology","Sitafloxacin Hydrate (DU-6859a) is a new-generation, broad-spectrum oral fluoroquinolone antibiotic.",436.84,"163253-35-8",{"v":4,"d":"4.00"},9.16,"<1","N/A","http://selleckchem.com/products/Sitafloxacin(DU-6859A).html","C19H18ClF2N3O3.3/2H2O","1.5 hydrate","DU-6859a","O.O.O.NC1CN(CC12CC2)C3=C(Cl)C4=C(C=C3F)C(=O)C(=CN4C5CC5F)C(O)=O.NC6CN(CC67CC7)C8=C(Cl)C9=C(C=C8F)C(=O)C(=CN9C%10CC%10F)C(O)=O",0.344,2,1,3]
["S2157","Taladegib (LY2940680)","h5","L3900-45","in 2mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Taladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. Phase 1/2.",{"v":512.5,"d":"512.50"},"1258861-20-9",{"v":5,"d":"5.00"},9.76,"<1","N/A","http://selleckchem.com/products/ly2940680.html","C26H24F4N6O","free base","N/A","C[N]1N=CC=C1C2=NN=C(N3CCC(CC3)N(C)C(=O)C4=C(C=C(F)C=C4)C(F)(F)F)C5=C2C=CC=C5",{"v":0,"d":"0.000"},0,0,0]
["S2206","Fostamatinib (R788) disodium","a6","L3900-45","in 2mM DMSO","Syk","Angiogenesis","Fostamatinib disodium  (R788, Tamatinib Fosdium), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.",624.42,"1025687-58-4",{"v":6,"d":"6.00"},9.61,"<1","N/A","http://selleckchem.com/products/R788(Fostamatinib-disodium).html","C23H24FN6O9P.2Na","Sodium Salt","Tamatinib Fosdium","[Na+].[Na+].COC1=C(OC)C(=CC(=C1)NC2=NC=C(F)C(=N2)NC3=CC=C4OC(C)(C)C(=O)N(CO[P]([O-])([O-])=O)C4=N3)OC",{"v":0,"d":"0.000"},0,0,0]
["S2232","Ketanserin","b6","L3900-45","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Ketanserin (R41468, Ketanserinum) is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.",395.43,"74050-98-9",{"v":2,"d":"2.00"},5.06,"<1","N/A","http://selleckchem.com/products/Ketanserin-Vulketan-Gel.html","C22H22FN3O3","Free Base","R41468, Ketanserinum","FC1=CC=C(C=C1)C(=O)C2CCN(CC2)CCN3C(=O)NC4=CC=CC=C4C3=O",2.991,3,1,5]
["S2251","(-)-Huperzine A (HupA)","c6","L3900-45","in 2mM DMSO","AChR,GluR","Neuronal Signaling","(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.",242.32,"102518-79-6",0.66,2.72,"<1","N/A","http://selleckchem.com/products/(-)-Huperzine-A.html","C15H18N2O","Free Base","N/A","C\\C=C/1C2CC3=C(C=CC(=O)N3)C1(N)CC(=C2)C",1.056,1,2,0]
["S2292","Diosmin","d6","L3900-45","in 2mM DMSO","AhR","Metabolism","Diosmin is an agonist of the aryl hydrocarbon receptor (AhR). Diosmin is a semisynthetic phlebotropic agent and a flavonoid found in a variety of citrus fruits.",608.55,"520-27-4",{"v":6,"d":"6.00"},9.86,"<1","N/A","http://selleckchem.com/products/Diosmin.html","C28H32O15","Free Base","N/A","COC1=C(O)C=C(C=C1)C2=CC(=O)C3=C(O2)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O",-0.395,7,8,7]
["S2476","Itraconazole (R 51211)","e6","L3900-45","in 2mM DMSO","Autophagy,Fungal,Hedgehog/Smoothened,P450 (e.g. CYP17)","Stem Cells & Wnt","Itraconazole (R 51211) is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.",705.65,"84625-61-6",{"v":7,"d":"7.00"},9.92,"<1","N/A","http://selleckchem.com/products/Itraconazole(Sporanox).html","C35H38Cl2N8O4","free base","R 51211","CCC(C)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C[N]6C=NC=N6)(O5)C7=CC=C(Cl)C=C7Cl)C=C4",6.434,7,0,11]
["S2582","Trazodone HCl","f6","L3900-45","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Trazodone HCl (AF-1161, KB-831) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.",408.32,"25332-39-2",{"v":4,"d":"4.00"},{"v":9.8,"d":"9.80"},"<1","N/A","http://selleckchem.com/products/trazodone-hydrochloride-desyrel.html","C19H22ClN5O.HCl","Hydrochloride","AF-1161, KB-831","Cl.ClC1=CC(=CC=C1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2",{"v":0,"d":"0.000"},0,0,0]
["S2597","Oseltamivir Phosphate","g6","L3900-45","in 2mM DMSO","Influenza Virus,Neuraminidase","Microbiology","Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.",{"v":410.4,"d":"410.40"},"204255-11-8",{"v":4,"d":"4.00"},9.75,"<1","N/A","http://selleckchem.com/products/oseltamivir-phosphate-Tamiflu.html","C16H28N2O4.H3PO4","Phosphate salt","Tamiflu","CCOC(=O)C1=CC(OC(CC)CC)C(NC(C)=O)C(N)C1.O[P](O)(O)=O",0.577,4,2,8]
["S2628","Gedatolisib (PKI-587)","h6","L3900-45","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.",615.73,"1197160-78-3",{"v":2,"d":"2.00"},3.25,"<1","N/A","http://selleckchem.com/products/pki587.html","C32H41N9O4","Free Base","PF-05212384","CN(C)C1CCN(CC1)C(=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C=C2",2.525,7,2,7]
["S2684","Pidnarulex (CX-5461)","a7","L3900-45","in 2mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.",513.61,"1138549-36-6",{"v":2,"d":"2.00"},3.89,"<1","N/A","http://www.selleck.cn/products/cx-5461.html","C27H27N7O2S","Free Base","N/A","CN1CCCN(CC1)C2=CC=C3C(=O)C(=C4SC5=C(C=CC=C5)N4C3=N2)C(=O)NCC6=CN=C(C)C=N6",3.188,5,1,4]
["S2735","MK-8776 (SCH 900776)","b7","L3900-45","in 2mM DMSO","CDK,Chk","Cell Cycle","MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.",376.25,"891494-63-6",{"v":3,"d":"3.00"},7.97,"<1","N/A","http://selleckchem.com/products/sch-900776.html","C15H18BrN7","Free Base","N/A","C[N]1C=C(C=N1)C2=C3N=C(C4CCCNC4)C(=C(N)[N]3N=C2)Br",{"v":1.32,"d":"1.320"},3,2,2]
["S2788","Capmatinib (INCB28060)","c7","L3900-45","in 2mM DMSO","Apoptosis related,c-Met,Wnt/beta-catenin","Protein Tyrosine Kinase","Capmatinib (INCB28060, INC280, NVP-INC280) is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1.",412.42,"1029712-80-8",{"v":2,"d":"2.00"},4.85,"<1","N/A","http://selleckchem.com/products/incb28060.html","C23H17FN6O","Free Base","INC280, NVP-INC280","CNC(=O)C1=CC=C(C=C1F)C2=N[N]3C(=CN=C3N=C2)CC4=CC=C5N=CC=CC5=C4",3.246,5,1,4]
["S2920","Mozavaptan","d7","L3900-45","in 2mM DMSO","Vasopressin Receptor","GPCR & G Protein","Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.",427.54,"137975-06-5",{"v":1,"d":"1.00"},2.34,"<1","N/A","http://selleckchem.com/products/mozavaptan.html","C27H29N3O2","Free Base","OPC-31260","CN(C)C1CCCN(C(=O)C2=CC=C(NC(=O)C3=C(C)C=CC=C3)C=C2)C4=C1C=CC=C4",4.654,2,1,4]
["S3041","Droxidopa","e7","L3900-45","in 2mM DMSO","Adrenergic Receptor","GPCR & G Protein","Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).",213.19,"23651-95-8",{"v":2,"d":"2.00"},9.38,{"v":1,"d":"1.00"},4.69,"http://www.selleck.cn/products/droxidopa-l-dops.html","C9H11NO5","Free Base","L-DOPS","NC(C(O)C1=CC(=C(O)C=C1)O)C(O)=O",-2.921,1,4,3]
["S3064","Ambroxol HCl","f7","L3900-45","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.",414.56,"23828-92-4",{"v":4,"d":"4.00"},9.65,"<1","N/A","http://selleckchem.com/products/ambroxol-hcl.html","C13H18Br2N2O.HCl","Hydrochloride","N/A","Cl.NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",3.121,0,3,3]
["S3636","Cefadroxil hydrate","g7","L3900-45","in 2mM DMSO","Antibiotics,Bacterial","Microbiology","Cefadroxil(BL-S 578 hydrate) is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.",{"v":381.4,"d":"381.40"},"66592-87-8",1.76,4.61,"N/A","N/A","http://selleckchem.com/products/cefadroxil-hydrate.html","C16H17N3O5S.H2O","hydrate","BL-S 578 hydrate","O.CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CC=C(O)C=C3)C2=O)C(O)=O",-2.704,3,3,4]
["S3721","Bilastine","h7","L3900-45","in 2mM DMSO","Histamine Receptor","Neuronal Signaling","Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.",463.61,"202189-78-4",{"v":1,"d":"1.00"},2.16,"<1","N/A","http://selleckchem.com/products/bilastine.html","C28H37N3O3","free base","N/A","CCOCC[N]1C(=NC2=C1C=CC=C2)C3CCN(CC3)CCC4=CC=C(C=C4)C(C)(C)C(O)=O",{"v":2.07,"d":"2.070"},3,0,10]
["S3891","Vincamine","a8","L3900-45","in 2mM DMSO","Others","Others","Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.",354.44,"1617-90-9",{"v":3,"d":"3.00"},8.46,"N/A","N/A","http://selleckchem.com/products/vincamine.html","C21H26N2O3","free base","Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan","CCC12CCCN3CCC4=C(C13)[N](C5=CC=CC=C45)C(O)(C2)C(=O)OC",3.546,2,0,3]
["S4126","Retinyl (Vitamin A) Palmitate","b8","L3900-45","in 2mM DMSO","Vitamin","Metabolism","Retinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid.",524.86,"79-81-2",{"v":3,"d":"3.00"},5.72,"<1","N/A","http://selleckchem.com/products/vitamin-a-palmitate.html","C36H60O2","Free Base","Vitamin A palmitate","CCCCCCCCCCCCCCCC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C",12.293,2,0,21]
["S4218","Amoxapine","c8","L3900-45","in 2mM DMSO","Amino acid transporter,GlyT","Neuronal Signaling","Amoxapine (CL 67772,Asendin) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.",313.78,"14028-44-5",{"v":3,"d":"3.00"},9.56,"<1","N/A","http://selleckchem.com/products/amoxapine.html","C17H16ClN3O","free base","CL 67772,Asendin","ClC1=CC2=C(OC3=C(C=CC=C3)N=C2N4CCNCC4)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S4262","Ebastine","d8","L3900-45","in 2mM DMSO","Histamine Receptor","Neuronal Signaling","Ebastine(LAS-W 090,RP64305) is a potent H1-histamine receptor antagonist, used for allergic disorders.",469.66,"90729-43-4",{"v":4,"d":"4.00"},8.52,"<1","N/A","http://selleckchem.com/products/ebastine.html","C32H39NO2","free base","LAS-W 090,RP64305","CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4",6.582,2,0,10]
["S4605","Folic acid","e8","L3900-45","in 2mM DMSO","Vitamin","Metabolism","Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.",{"v":441.4,"d":"441.40"},"59-30-3",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/folic-acid.html","C19H19N7O6","free base","Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate","NC1=NC(=O)C2=C(N1)N=CC(=N2)CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",-0.232,7,4,9]
["S4642","Dolutegravir Sodium","f8","L3900-45","in 2mM DMSO","Integrase","Microbiology","Dolutegravir Sodium (GSK-1349572A) is a HIV integrase inhibitor with IC50 of 2.7 nM.",441.36,"1051375-19-9",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://www.selleck.cn/products/dolutegravir-sodium.html","C20H19F2N3O5.Na","Sodium","GSK-1349572A","CC1CCOC2CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(=C3C(=O)N12)O[Na]",0.391,5,1,4]
["S4654","Netupitant","g8","L3900-45","in 2mM DMSO","Neurokinin Receptor","Neuronal Signaling","Netupitant (CID6451149) is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.",578.59,"290297-26-6",{"v":2,"d":"2.00"},3.46,"<1","N/A","http://selleckchem.com/products/netupitant.html","C30H32F6N4O","Free Base","CID6451149, CID 6451149, CID-6451149","CN1CCN(CC1)C2=CC(=C(C=N2)N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C4=CC=CC=C4C",7.132,2,0,7]
["S4930","Cetilistat","h8","L3900-45","in 2mM DMSO","Lipase","Metabolism","Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo",401.58,"282526-98-1",{"v":3,"d":"3.00"},7.47,"<1","N/A","http://selleckchem.com/products/cetilistat.html","C25H39NO3","free base","ATL962","CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C)C=C2)C(=O)O1",9.409,4,0,16]
["S5116","Bilibubin","a9","L3900-45","in 2mM DMSO","Others","Others","Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.",584.66,"635-65-4",{"v":3,"d":"3.00"},5.13,"N/A","N/A","http://selleckchem.com/products/bilibubin.html","C33H36N4O6","free base","Bilirubin","CC1=C(C=C)/C(NC1=O)=C/C2=C(C)C(=C(CC3=C(CCC(O)=O)C(=C([NH]3)\\C=C\\4NC(=O)C(=C4C)C=C)C)[NH]2)CCC(O)=O",5.055,4,4,12]
["S5232","Alectinib (CH5424802) hydrochloride","b9","L3900-45","in 2mM DMSO","ALK","Protein Tyrosine Kinase","Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.",519.08,"1256589-74-8",{"v":2,"d":"2.00"},3.85,"<1","N/A","http://selleckchem.com/products/alectinib-hydrochloride.html","C30H34N4O2.HCl","hydrochloride","AF802, RO5424802, RG-7853","Cl.CCC1=C(C=C2C(=C1)C(=O)C3=C([NH]C4=C3C=CC(=C4)C#N)C2(C)C)N5CCC(CC5)N6CCOCC6",5.585,2,1,3]
["S5499","Amantadine","c9","L3900-45","in 2mM DMSO","Influenza Virus","Microbiology","Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.",151.25,"768-94-5",{"v":1,"d":"1.00"},6.61,"N/A","N/A","http://selleckchem.com/products/amantadine.html","C10H17N","free base","1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane","N[C]12C[CH]3[CH2]C([CH2][CH](C3)C1)C2",1.495,0,1,0]
["S5601","Balofloxacin Dihydrate","d9","L3900-45","in 2mM DMSO","Antibiotics","Microbiology","Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic.",425.45,"151060-21-8",{"v":2,"d":"2.00"},{"v":4.7,"d":"4.70"},"<1","N/A","https://www.selleckchem.com/products/balofloxacin-dihydrate.html","C20H28FN3O6","free base","Neuroquinoron","O.O.CNC1CCCN(C1)C2=C(F)C=C3C(=O)C(=CN(C4CC4)C3=C2OC)C(O)=O",-1.029,3,1,5]
["S5712","Zofenopril calcium","e9","L3900-45","in 2mM DMSO","RAAS","Endocrinology & Hormones","Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.",897.17,"81938-43-4","N/A",{"v":2,"d":"2.00"},"<1","N/A","http://selleckchem.com/products/zofenopril-calcium.html","C44H44CaN2O8S4","calcium salt","SQ-26991","CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)O[Ca]OC(=O)C3CC(CN3C(=O)C(C)CSC(=O)C4=CC=CC=C4)SC5=CC=CC=C5)SC6=CC=CC=C6",8.055,8,0,20]
["S5908","Garenoxacin","f9","L3900-45","in 2mM DMSO","Anti-infection","Microbiology","Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.",426.41,"194804-75-6",{"v":2,"d":"2.00"},4.69,"<1","N/A","http://www.selleckchem.com/products/garenoxacin.html","C23H20F2N2O4","Free Base","T-3811ME, BMS-284756","CC1NCC2=C1C=CC(=C2)C3=C(OC(F)F)C4=C(C=C3)C(=O)C(=CN4C5CC5)C(O)=O",0.934,3,1,5]
["S6001","pomaglumetad (LY404039)","g9","L3900-45","in 2mM DMSO","GluR","Neuronal Signaling","LY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3.",235.22,"635318-11-5",{"v":1,"d":"1.00"},4.25,"<1","N/A","http://selleckchem.com/products/LY2140023(LY404039).html","C7H9NO6S","Free Base","N/A","NC1(C[S](=O)(=O)C2C(C12)C(O)=O)C(O)=O",-4.682,4,1,2]
["S6632","Mirogabalin (DS-5565)","h9","L3900-45","in 2mM DMSO","Others","Others","Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain.",209.28,"1138245-13-2",{"v":2,"d":"2.00"},9.56,{"v":3,"d":"3.00"},14.33,"http://www.selleck.cn/products/mirogabalin-ds-5565.html","C12H19NO2","Free Base","N/A","CCC1=CC2C(C1)CC2(CN)CC(O)=O",-1.352,1,1,4]
["S6642","Branaplam (LMI070)","a10","L3900-45","in 2mM DMSO","SMN","DNA Damage/DNA Repair","Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM.",393.48,"1562338-42-4",{"v":3,"d":"3.00"},7.62,"<1","N/A","http://www.selleck.cn/products/branaplam-lmi070.html","C22H27N5O2","Free Base","N/A","CC1(C)CC(CC(C)(C)N1)OC2=NN=C(C=C2)C3=C(O)C=C(C=C3)C4=C[NH]N=C4",3.141,4,3,4]
["S6719","E6446 dihydrochloride","b10","L3900-45","in 2mM DMSO","TLR","Immunology & Inflammation","E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor.",522.51,"1345675-25-3",{"v":3,"d":"3.00"},5.74,{"v":100,"d":"100.00"},191.38,"https://www.selleckchem.com/products/e6446-dihydrochloride.html","C27H37Cl2N3O3","Dihydrochloride","N/A","Cl.Cl.C1CCN(C1)CCCOC2=CC=C(C=C2)C3=NC4=C(O3)C=C(OCCCN5CCCC5)C=C4",5.336,4,0,11]
["S7004","EPZ005687","c10","L3900-45","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.",539.67,"1396772-26-1",{"v":2,"d":"2.00"},3.71,"<1","N/A","http://selleckchem.com/products/epz005687.html","C32H37N5O3","Free Base","N/A","CC1=CC(=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C4CCCC4)C5=CC=C(CN6CCOCC6)C=C5)C(=O)N1)C",3.919,4,2,7]
["S7035","XL388","d10","L3900-45","in 2mM DMSO","mTOR","PI3K/Akt/mTOR","XL388 is a highly potent, selective, ATP-competitive inhibitor of  mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.",{"v":455.5,"d":"455.50"},"1251156-08-7",1.25,2.74,"<1","N/A","http://selleckchem.com/products/xl388.html","C23H22FN3O4S","free base","N/A","CC1=C(F)C(=CC=C1C(=O)N2CCOC3=CC=C(C=C3C2)C4=CN=C(N)C=C4)[S](C)(=O)=O",3.007,5,1,3]
["S7061","GSK126","e10","L3900-45","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases.",526.67,"1346574-57-9",{"v":3,"d":"3.00"},{"v":5.7,"d":"5.70"},"<1","N/A","http://selleckchem.com/products/gsk126.html","C31H38N6O2","Free Base","GSK2816126A, GSK2816126","CCC(C)[N]1C=C(C)C2=C(C=C(C=C12)C3=CC=C(N=C3)N4CCNCC4)C(=O)NCC5=C(C)C=C(C)NC5=O",4.114,3,3,7]
["S7128","Tazemetostat (EPZ-6438)","f10","L3900-45","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.",572.74,"1403254-99-8",{"v":5,"d":"5.00"},8.73,"<1","N/A","http://selleckchem.com/products/epz-6438.html","C34H44N4O4","free base","E7438","CCN(C1CCOCC1)C2=C(C)C(=CC(=C2)C3=CC=C(CN4CCOCC4)C=C3)C(=O)NCC5=C(C)C=C(C)NC5=O",3.506,4,2,9]
["S7221","Vesatolimod (GS-9620)","g10","L3900-45","in 2mM DMSO","TLR","Immunology & Inflammation","Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7.",410.51,"1228585-88-3",{"v":1,"d":"1.00"},2.44,"<1","N/A","http://selleckchem.com/products/gs-9620.html","C22H30N6O2","Free Base","N/A","CCCCOC1=NC(=C2NC(=O)CN(CC3=CC=CC(=C3)CN4CCCC4)C2=N1)N",3.302,4,2,8]
["S7518","Voreloxin (SNS-595) hydrochloride","h10","L3900-45","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.",{"v":437.9,"d":"437.90"},"175519-16-1",{"v":1,"d":"1.00"},2.28,{"v":1,"d":"1.00"},2.28,"http://selleckchem.com/products/voreloxin-sns-595.html","C18H20ClN5O4S","hydrochloride","Vosaroxin","Cl.CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(O)=O",-1.138,5,1,5]
["S7698","LY2584702","a11","L3900-45","in 2mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.",445.42,"1082949-67-4",{"v":1,"d":"1.00"},2.25,"<1","N/A","http://selleckchem.com/products/ly2584702.html","C21H19F4N7","Free Base","N/A","C[N]1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=N[NH]4)C5=CC=C(F)C(=C5)C(F)(F)F",{"v":4.18,"d":"4.180"},4,1,4]
["S7756","Indoximod (NLG-8189）","b11","L3900-45","in 2mM DMSO","IDO/TDO","Metabolism","Indoximod (NLG-8189, 1-Methyl-D-tryptophan, 1-MT), a methylated tryptophan, acts as an IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor, and reverses IDO-mediated immune suppression. Phase 2.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!",218.25,"110117-83-4",{"v":1,"d":"1.00"},4.58,"<1","N/A","http://selleckchem.com/products/indoximod-nlg-8189.html","C12H14N2O2","Free Base","1-Methyl-D-tryptophan, 1-MT","C[N]1C=C(CC(N)C(O)=O)C2=CC=CC=C12",-1.106,1,1,3]
["S7819","BLU9931","c11","L3900-45","in 2mM DMSO","FGFR","Angiogenesis","BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.",509.38,"1538604-68-0",{"v":4,"d":"4.00"},7.85,"<1","N/A","http://selleckchem.com/products/blu9931.html","C26H22Cl2N4O3","Free Base","N/A","COC1=CC(=C(Cl)C(=C1Cl)C2=CC3=CN=C(NC4=C(NC(=O)C=C)C=CC=C4C)N=C3C=C2)OC",6.577,5,2,7]
["S7842","LY3009120","d11","L3900-45","in 2mM DMSO","Autophagy,Raf","MAPK","LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. LY03009120 induces autophagy. Phase 1.",424.51,"1454682-72-4",{"v":3,"d":"3.00"},7.07,"<1","N/A","http://selleckchem.com/products/ly3009120.html","C23H29FN6O","Free Base","DP-4978","CNC1=NC=C2C=C(C(=NC2=N1)C)C3=CC(=C(F)C=C3C)NC(=O)NCCC(C)(C)C",4.158,4,3,6]
["S7846","Dubermatinib(TP-0903)","e11","L3900-45","in 2mM DMSO","Apoptosis related,Axl","Protein Tyrosine Kinase","TP-0903 is a potent and selective AXL Inhibitor with IC50 of 27 nM. TP-0903 is highly effective in inducing apoptosis.",516.06,"1341200-45-0",{"v":3,"d":"3.00"},5.81,"<1","N/A","http://selleckchem.com/products/tp-0903.html","C24H30ClN7O2S","Free Base","N/A","CN1CCN(CC1)CC2=CC=C(NC3=NC=C(Cl)C(=N3)NC4=CC=CC=C4[S](=O)(=O)N(C)C)C=C2",4.023,4,2,8]
["S8012","Otenabant (CP-945598) HCl","f11","L3900-45","in 2mM DMSO","Cannabinoid Receptor","GPCR & G Protein","Otenabant (CP-945598) HCl is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor. Phase 1.",546.88,"686347-12-6",{"v":5,"d":"5.00"},9.14,"<1","N/A","http://selleckchem.com/products/cp-945598-hcl.html","C25H25Cl2N7O.HCl","Hydrochloride","Otenabant","Cl.CCNC1(CCN(CC1)C2=NC=NC3=C2N=C([N]3C4=CC=C(Cl)C=C4)C5=CC=CC=C5Cl)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["S8138","Molidustat (BAY 85-3934)","g11","L3900-45","in 2mM DMSO","HIF","Angiogenesis","Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.",{"v":314.3,"d":"314.30"},"1154028-82-6",{"v":3,"d":"3.00"},9.55,"<1","N/A","http://selleckchem.com/products/molidustat-(bay85-3934).html","C13H14N8O2","free base","N/A","O=C1N(NC=C1[N]2C=CN=N2)C3=NC=NC(=C3)N4CCOCC4",{"v":0,"d":"0.000"},0,0,0]
["S8229","Brigatinib (AP26113)","h11","L3900-45","in 2mM DMSO","ALK,EGFR,FLT3,IGF-1R,ROS1","Angiogenesis","Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.",584.09,"1197953-54-0",{"v":3,"d":"3.00"},5.14,"<1","N/A","http://www.selleck.cn/products/brigatinib-ap26113.html","C29H39ClN7O2P","Free Base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)NC3=CC=CC=C3[P](C)(C)=O)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.084,6,2,8]
["S8548","Roblitinib (FGF401)","a2","L3900-46","in 2mM DMSO","FGFR","Protein Tyrosine Kinase","Roblitinib (FGF401) is an FGFR4-selective inhibitor with an IC50 of 1.9 nM. It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.",506.56,"1708971-55-4",{"v":5,"d":"5.00"},9.87,"<1","N/A","http://selleckchem.com/products/fgf401.html","C25H30N8O4","free base","N/A","COCCNC1=C(C=NC(=C1)NC(=O)N2CCCC3=C2N=C(C=O)C(=C3)CN4CCN(C)CC4=O)C#N",0.939,6,2,8]
["S8568","G1T38","b2","L3900-46","in 2mM DMSO","CDK","Cell Cycle","G1T38 (Lerociclib) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively.",{"v":474.6,"d":"474.60"},"1628256-23-4",{"v":2,"d":"2.00"},4.21,"<1","N/A","http://www.selleck.cn/products/g1t38.html","C26H34N8O","free base","Lerociclib","CC(C)N1CCN(CC1)C2=CN=C(NC3=NC4=C(C=N3)C=C5[N]4C6(CCCCC6)CNC5=O)C=C2",4.087,4,2,4]
["S8724","Lazertinib","c2","L3900-46","in 2mM DMSO","EGFR","Protein Tyrosine Kinase","Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.",554.64,"1903008-80-9",{"v":4,"d":"4.00"},7.21,"<1","N/A","http://selleckchem.com/products/lazertinib-yh25448-gns-1480.html","C30H34N8O3","free base","YH25448,GNS-1480","COC1=CC(=C(NC(=O)C=C)C=C1NC2=NC=CC(=N2)[N]3C=C(CN(C)C)C(=N3)C4=CC=CC=C4)N5CCOCC5",{"v":4.56,"d":"4.560"},6,2,10]
["S5098","Gefitinib hydrochloride","d2","L3900-46","in 2mM DMSO","EGFR","Protein Tyrosine Kinase","Gefitinib (ZD1839) is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.",483.36,"184475-55-6","N/A",{"v":2,"d":"2.00"},{"v":1,"d":"1.00"},2.07,"http://selleckchem.com/products/gefitinib-hydrochloride.html","C22H24ClFN4O3.HCl","hydrochloride","ZD1839 hydrochloride","Cl.COC1=CC2=C(C=C1OCCCN3CCOCC3)C(=NC=N2)NC4=CC(=C(F)C=C4)Cl",4.585,5,1,8]
["S8927","GSK2983559 (compound 3)","e2","L3900-46","in 2mM DMSO","RIP kinase","Apoptosis","GSK2983559 (compound 3, RIP2 kinase inhibitor 1, RIPK2-IN-1) is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity.",538.53,"1579965-12-0",{"v":5,"d":"5.00"},9.28,"<1","N/A","http://www.selleck.cn/products/gsk2983559-compound-3.html","C21H23N4O7PS2","Free Base","RIP2 kinase inhibitor 1, RIPK2-IN-1","CC(C)(C)[S](=O)(=O)C1=CC2=C(NC3=CC=C4SC=NC4=C3)N=CN=C2C=C1OCCO[P](O)(O)=O",3.391,7,1,9]
["S1502","Cephalexin","f2","L3900-46","in 2mM DMSO","Antibiotics,Bacterial","Microbiology","Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.",347.39,"15686-71-2","N/A",{"v":2,"d":"2.00"},"N/A","N/A","http://selleckchem.com/products/Cephalexin-(Cefalexin).html","C16H17N3O4S","free base","Cefalexin","CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CC=CC=C3)C2=O)C(O)=O",-2.255,3,2,4]
["S8875","MKC8866","g2","L3900-46","in 2mM DMSO","IRE1","ER stress & UPR","MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.",361.35,"1338934-59-0",{"v":3,"d":"3.00"},{"v":8.3,"d":"8.30"},"˂1","N/A","http://www.selleckchem.com/products/mkc8866.html","C18H19NO7","Free Base","IRE1-IN-8866","COC1=C(O)C(=C2OC(=O)C(=C(C)C2=C1)CC(=O)N3CCOCC3)C=O",0.943,6,1,4]
["S0063","RG3039","h2","L3900-46","in 2mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is an orally bioavailable and brain-penetrant inhibitor of the mRNA decapping enzyme DcpS with IC50 of 4.2 nM and IC90 of 40 nM, respectively.",432.35,"1005504-62-0",{"v":3,"d":"3.00"},6.94,"<1","N/A","https://www.selleckchem.com/products/rg3039.html","C21H23Cl2N5O","Free Base","PF-06687859, PF 6687859, Quinazoline 495","NC1=NC(=C2C(=CC=CC2=N1)OCC3CCN(CC3)CC4=C(Cl)C=CC=C4Cl)N",4.539,3,2,5]
["S6949","OTX008","a3","L3900-46","in 2mM DMSO","Galectin","Immunology & Inflammation","OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with anti-tumoural activity.",937.18,"286936-40-1",{"v":3,"d":"3.00"},{"v":3.2,"d":"3.20"},"<1","N/A","https://www.selleckchem.com/products/otx008.html","C52H72N8O8","Free Base","Calixarene 0118, PTX-008","CN(C)CCNC(=O)COC1=C2CC3=CC=CC(=C3OCC(=O)NCCN(C)C)CC4=CC=CC(=C4OCC(=O)NCCN(C)C)CC5=CC=CC(=C5OCC(=O)NCCN(C)C)CC1=CC=C2",4.626,8,4,24]
["S4482","Palbociclib","b3","L3900-46","in 2mM DMSO","CDK","Cell Cycle","Palbociclib (Ibrance, PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.",447.53,"571190-30-2",{"v":3,"d":"3.00"},{"v":6.7,"d":"6.70"},"<1","N/A","http://www.selleckchem.com/products/palbociclib.html","C24H29N7O2","Free Base","Ibrance, PD 0332991","CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O",2.801,5,2,5]
["E0524","Spinosad","c3","L3900-46","in 2mM DMSO","AChR,Anti-infection","Neuronal Signaling","Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete, is a biological neurotoxic insecticide with a broader action spectrum, targeting the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system.",731.96,"168316-95-8",{"v":3,"d":"3.00"},{"v":4.1,"d":"4.10"},"<1","N/A","http://www.selleckchem.com/products/spinosad.html","C41H65NO10","free base","N/A","NA","NA","NA","NA","NA"]
["S3309","Solasodine","d3","L3900-46","in 2mM DMSO","Akt,MicroRNA,MMP,PI3K","Proteases","Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.",413.64,"126-17-0",{"v":2,"d":"2.00"},4.84,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/solasodine.html","C27H43NO2","free base","Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine","CC1CCC2(NC1)OC3CC4C5CC=C6CC(O)CCC6(C)C5CCC4(C)C3C2C",4.367,1,2,0]
["S7178","Prexasertib HCl (LY2606368)","e3","L3900-46","in 2mM DMSO","Chk","Cell Cycle","Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay.",438.31,"1234015-54-3",{"v":2,"d":"2.00"},4.56,"<1","N/A","http://www.selleckchem.com/products/ly2606368.html","C18H19N7O2.2HCl","dihydrochloride","N/A","Cl.Cl.COC1=CC=CC(=C1C2=CC(=N[NH]2)NC3=NC=C(N=C3)C#N)OCCCN",2.682,5,3,8]
["S3570","ARRY-382","f3","L3900-46","in 2mM DMSO","CSF-1R","Protein Tyrosine Kinase","ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.",564.68,"1313407-95-2",{"v":5,"d":"5.00"},8.85,"<1","N/A","http://www.selleckchem.com/products/arry-382.html","C32H36N8O2","Free base","N/A","CN1CCN(CCOC2=CC3=NC=C([N]3C=C2)C(=O)NC4=C5C(=CC=C4)[N](CC6=CC=CC(=N6)C)N=C5C7CC7)CC1",3.684,5,1,9]
["S6385","Prexasertib (LY2606368)","g3","L3900-46","in 2mM DMSO","Chk,S6 Kinase","Cell Cycle","Prexasertib (LY2606368, ACR 368) is a selective ATP competitor inhibitor of Chk1 and Chk2 with IC50s of 1 nM and 8 nM in cell-free assays, respectively. Prexasertib also inhibits RSK1 with an IC50 of 9 nM in cell-free assay.",365.39,"1234015-52-1",{"v":3,"d":"3.00"},8.21,"<1","N/A","http://www.selleckchem.com/products/prexasertib-ly2606368.html","C18H19N7O2","Free base","ACR 368","COC1=C(C2=CC(=N[NH]2)NC3=CN=C(C=N3)C#N)C(=CC=C1)OCCCN",1.918,5,3,8]
["S7089","SM-164","h3","L3900-46","in 2mM DMSO","IAP","Apoptosis","SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces apoptosis and tumor regression.",1121.42,"957135-43-2",{"v":3,"d":"3.00"},2.68,"<1","N/A","http://www.selleckchem.com/products/sm-164.html","C62H84N14O6","Free base","N/A","CNC(C)C(=O)NC1CCCCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=C[N](CCCCC5=CC=C(CCCC[N]6C=C(N=N6)C(NC(=O)C7CCC8CCCCC(NC(=O)C(C)NC)C(=O)N78)C9=CC=CC=C9)C=C5)N=N4",6.779,10,6,24]
["S9464","Tranylcypromine Sulfate","a4","L3900-46","in 2mM DMSO","MAO","Metabolism","Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.",364.46,"13492-01-8",{"v":2,"d":"2.00"},5.49,"<1","N/A","http://www.selleckchem.com/products/tranylcypromine-sulfate.html","C18H24N2O4S","Sulfate","Parnate","NC1CC1C2=CC=CC=C2.NC3CC3C4=CC=CC=C4.O[S;v6](O)(=O)=O",{"v":1.78,"d":"1.780"},0,2,2]
["S9826","TPX-0046","b4","L3900-46","in 2mM DMSO","c-RET,Src","Protein Tyrosine Kinase","TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.",424.43,"2359650-19-2",{"v":2,"d":"2.00"},4.71,"<1","N/A","http://www.selleckchem.com/products/tpx-0046.html","C21H21FN6O3","Free base","N/A","CC1CNC(=O)C2=C3N=C4N(CC5=C(O1)N=CC(=C5)F)C6CCCC6OC4=C[N]3N=C2",2.146,6,1,0]
["S9872","AG-270","c4","L3900-46","in 2mM DMSO","MAT2A","Methylation","AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels  and MTAP-null–selective antiproliferative activity.",489.57,"2201056-66-6",{"v":3,"d":"3.00"},6.13,"<1","N/A","https://www.selleckchem.com/products/ag-270.html","C30H27N5O2","Free base","N/A","COC1=CC=C(C=C1)C2=C(NC3=CC=CC=N3)NC4=C(C5=CCCCC5)C(=N[N]4C2=O)C6=CC=CC=C6",6.837,4,2,6]
["E4468","Cabotegravir Sodium","d4","L3900-46","in 2mM DMSO","Integrase","Microbiology","Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor. It also inhibits organic anion transporter 1/3 (OAT1/OAT3) with IC50 of 0.41 μM and 0.81 μM for OAT3 and OAT1, respectively.",428.34,"1051375-13-3",{"v":2,"d":"2.00"},4.67,"<1","N/A","https://www.selleckchem.com/products/cabotegravir-sodium.html","C19H17F2N3O5.Na","sodium salt","GSK-1265744 sodium","[Na;v0].CC1COC2CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(=C3C(=O)N12)O",0.237,4,2,3]
["S1346","Heparin sodium","a2","L3900-47","in 2mM Water","Autophagy,Factor Xa,Thrombin","Proteases","Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.","6000-20000","9041-08-1","<1","N/A",{"v":100,"d":"100.00"},{"v":8,"d":"8.00"},"http://selleckchem.com/products/Heparin-sodium.html","(C12H16NS2Na3)20","Sodium salt","N/A","CCC1CC(N[R])C(OC1CO[S]([O-])(=O)=O)OC2C(O)C(O)C(OC3C(CO[R])OC(OC4C(O)C(O[S]([O-])(=O)=O)C(OC5C(O)C(N[S]([O-])(=O)=O)C(C)OC5CO[S]([O-])(=O)=O)OC4C([O-])=O)C(N[S]([O-])(=O)=O)C3[S]([O-])(=O)=O)OC2C([O-])=O",-22.565,13,7,27]
["S1428","Risedronate Sodium","b2","L3900-47","in 2mM Water","Others","Metabolism","Risedronate (NE 58095) sodium, a nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption and modulates bone metabolism, used in the treatment of osteoporosis.",305.09,"115436-72-1","<1","N/A",{"v":2,"d":"2.00"},6.56,"http://selleckchem.com/products/Risedronate-sodium.html","C7H10NNaO7P2","Sodium salt","NE 58095 Sodium","[Na+].OC(CC1=CC=CN=C1)([P](O)(O)=O)[P](O)([O-])=O",-1.737,1,0,4]
["S1911","Disodium Cromoglycate","c2","L3900-47","in 2mM Water","Calcium Channel","Transmembrane Transporters","Disodium Cromoglycate (Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium) is an antiallergic drug with IC50 of 39 μg/mL.",512.33,"15826-37-6","<1","N/A",{"v":2,"d":"2.00"},{"v":3.9,"d":"3.90"},"http://selleckchem.com/products/disodium-Cromoglycate.html","C23H14O11.2Na","Disodium Salt","Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium","[Na+].[Na+].OC(COC1=C2C(=O)C=C(OC2=CC=C1)C([O-])=O)COC3=CC=CC4=C3C(=O)C=C(O4)C([O-])=O",-1.178,6,1,8]
["S1982","Adenine sulfate","d2","L3900-47","in 2mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Adenine sulfate(Adenine hemisulfate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.",368.33,"321-30-2","<1","N/A",{"v":2,"d":"2.00"},5.43,"http://selleckchem.com/products/adenine-sulfate.html","2(C5H5N5).H2SO4","Sulfate","Adenine hemisulfate","NC1=NC=NC2=C1[NH]C=N2.NC3=NC=NC4=C3[NH]C=N4.O[S](O)(=O)=O",-1.498,6,4,0]
["S2106","Azasetron HCl","e2","L3900-47","in 2mM Water","5-HT Receptor","Neuronal Signaling","Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.",386.27,"123040-16-4","<1","N/A",{"v":3,"d":"3.00"},7.77,"http://selleckchem.com/products/azasetron-hcl.html","C17H20ClN3O3.HCl","HCl","Y-25130 HCl","Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC3CN4CCC3CC4",1.616,3,1,2]
["S2562","Hydralazine HCl","f2","L3900-47","in 2mM Water","Potassium Channel","Transmembrane Transporters","Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.",196.64,"304-20-1","<1","N/A",{"v":1,"d":"1.00"},5.09,"http://selleckchem.com/products/Hydralazine-hydrochloride.html","C8H8N4.HCl","Hydrochloride","N/A","Cl.N/N=C/1NN=CC2=C1C=CC=C2",0.798,2,2,0]
["S3055","Besifloxacin HCl","g2","L3900-47","in 2mM Water","Antibiotics","Microbiology","Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic.",{"v":430.3,"d":"430.30"},"405165-61-9","<1","N/A",{"v":1,"d":"1.00"},2.32,"http://selleckchem.com/products/besifloxacin-hci.html","C19H21ClFN3O3.HCl","Hydrochloride","N/A","Cl.NC1CCCCN(C1)C2=C(Cl)C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O",0.698,2,1,3]
["S3749","Calcium gluconate monohydrate","h2","L3900-47","in 2mM Water","Others","Others","Calcium gluconate (Calcarea gluconica, Calcium gluconate anhydrous, Calcium D-gluconate, Calciofon, Glucobiogen) is element or mineral necessary for normal nerve, muscle, and cardiac function. Calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally.",448.39,"66905-23-5","<1","N/A",{"v":4,"d":"4.00"},8.92,"http://selleckchem.com/products/calcium-gluconate.html","C12H22O14.Ca.H2O","monohydrate","Calcarea gluconica, Calcium gluconate anhydrous, Calcium D-gluconate, Calciofon, Glucobiogen","O.[Ca++].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O",-8.781,0,10,10]
["S4067","Deferiprone","a3","L3900-47","in 2mM Water","Others","Others","Deferiprone (CP20) is a chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values.",139.15,"30652-11-0","<1","N/A",{"v":1,"d":"1.00"},7.19,"http://selleckchem.com/products/deferiprone.html","C7H9NO2","Free Base","CP20","CN1C=CC(=O)C(=C1C)O",-0.139,1,1,0]
["S4226","Minocycline (CL 59806) HCl","b3","L3900-47","in 2mM Water","Antibiotics","Microbiology","Minocycline (CL 59806,Minocin) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.",493.94,"13614-98-7","<1","N/A",{"v":1,"d":"1.00"},2.02,"http://selleckchem.com/products/minocycline-hcl.html","C23H27N3O7.HCl","Hydrochloride","Minocin","Cl.CN(C)C1C2CC3CC4=C(C(=CC=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",{"v":0,"d":"0.000"},0,0,0]
["S4694","Alosetron Hydrochloride","c3","L3900-47","in 2mM Water","5-HT Receptor","Neuronal Signaling","Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.",330.81,"122852-69-1","<1","N/A",{"v":1,"d":"1.00"},3.02,"http://selleckchem.com/products/alosetron-hydrochloride.html","C17H18N4O.HCl","hydrochloride","GR 68755C, GR 68755, GR 68755X, Lotronex, GR-68755, GR68755","Cl.C[N]1C2=C(C(=O)N(CC2)CC3=C(C)N=C[NH]3)C4=C1C=CC=C4",2.036,2,1,2]
["S5355","Piperaquine phosphate","d3","L3900-47","in 2mM Water","Anti-infection","Microbiology","Piperaquine phosphate is an orally active bisquinolone antimalarial drug.",633.51,"85547-56-4","<1","N/A",{"v":2,"d":"2.00"},3.16,"http://selleckchem.com/products/piperaquine-phosphate.html","C29H32Cl2N6.H3O4P","phosphate","N/A","O[P](O)(O)=O.ClC1=CC=C2C(=C1)N=CC=C2N3CCN(CCCN4CCN(CC4)C5=C6C=CC(=CC6=NC=C5)Cl)CC3",5.012,2,0,6]
["S5695","Icatibant Acetate","e3","L3900-47","in 2mM Water","Bradykinin Receptor","GPCR & G Protein","Icatibant Acetate(HOE-140 acetate) acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.",1364.57,"138614-30-9",{"v":-1,"d":"-1.00"},"N/A",{"v":11,"d":"11.00"},8.06,"http://www.selleckchem.com/products/icatibant-acetate.html","C61H93N19O15S","Acetate","HOE-140 acetate","CC(O)=O.NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CC(O)CC2C(=O)NCC(=O)NC(CC3=CC=CS3)C(=O)NC(CO)C(=O)N4CC5=C(CC4C(=O)N6C7CCCCC7CC6C(=O)NC(CCCNC(N)=N)C(O)=O)C=CC=C5",-6.943,11,14,33]
["S8030","Plerixafor (AMD3100)","f3","L3900-47","in 2mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.",502.78,"110078-46-1","<1","N/A",{"v":3,"d":"3.00"},5.97,"http://selleckchem.com/products/plerixafor.html","C28H54N8","Free Base","JM 3100, SID791","C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",{"v":-0.52,"d":"-0.520"},0,6,4]
["S5650","Sodium Hyaluronate","g3","L3900-47","in 2mM Water","Others","Others","Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans.",{"v":401.3,"d":"401.30"},"9067-32-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A",{"v":2,"d":"2.00"},"https://www.selleckchem.com/products/sodium-hyaluronate.html","C14H20NNaO11R","free base","N/A","[Na+].CC(=O)NC1C(C(O)C(CO)OC1OC2C(O)C(O)C(O[*])OC2C([O-])=O)[*]",-4.314,5,5,6]
["S2095","Fosinopril Sodium","h3","L3900-47","in 2mM Water","ACE,RAAS","Endocrinology & Hormones","Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.",585.64,"88889-14-9","N/A","N/A","N/A",{"v":2,"d":"2.00"},"http://selleckchem.com/products/fosinopril-sodium-monopril.html","C30H45NO7P.Na","Sodium Salt","SQ28555","[Na+].CCC(=O)OC(O[P](=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C([O-])=O)C3CCCCC3)C(C)C",4.129,5,0,15]
["S2050","Strontium Ranelate","a4","L3900-47","in 2mM Water","Calcium Channel","Transmembrane Transporters","Strontium Ranelate is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.",513.49,"135459-87-9","<1","N/A",{"v":2,"d":"2.00"},3.89,"http://www.selleckchem.com/products/strontium-ranelate-protelos.html","C12H6N2O8S.2Sr","Free base","N/A","O=C1CN(CC(=O)O[Sr]O1)C2=C(C#N)C3=C(S2)C(=O)O[Sr]OC(=O)C3",0.569,8,0,1]
["S4444","Hypromellose","a2","L3900-48","in 2mg/ml DMSO","others","others","Hypromellose (Hydroxypropyl Methyl Cellulose, HPMC, Celacol HPM 5000) is a commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect.","N/A","9004-65-3",{"v":100,"d":"100.00"},"N/A",{"v":100,"d":"100.00"},"N/A","https://www.selleckchem.com/products/hypromellose.html","N/A","Free Base","Hydroxypropyl Methyl Cellulose, HPMC, Celacol HPM 5000, Hydroxypropylmethyl cellulose","N/A","N/A","N/A","N/A","N/A"]