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[{"$nulls":3},"Anti-Aging Compound Library  (96-well)-L6200"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 2308 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L6200-01~27;    In 2 mM DMSO : Plate layout L6200-29"]
[{"$nulls":3},"In 10 mM Water: Plate layout L6200-28;      In 2 mM Water  : Plate layout L6200-30"]
[]
[]
[null,"Plate layout: L6200-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1002","S1017","S1035","S1047","S1061","S1077","S1090","S1102","S1117","S1134","Empty"]
[{"$nulls":3},"ABT-737","Cediranib (AZD2171)","Pazopanib HCl (GW786034 HCl)","Vorinostat (SAHA)","Nutlin-3","SB202190 (FHPI)","Abexinostat (PCI-24781)","U0126-EtOH","Triciribine (NSC 154020)","AT9283"]
[null,"b","Empty","S1003","S1021","S1036","S1048","S1065","S1078","S1091","S1103","S1120","S1138","Empty"]
[{"$nulls":3},"Linifanib (ABT-869)","Dasatinib (BMS-354825)","Mirdametinib (PD0325901)","Tozasertib","Pictilisib (GDC-0941)","MK-2206 2HCl","Linsitinib (OSI-906)","ZM 447439","Everolimus (RAD001)","Brivanib Alaninate (BMS-582664)"]
[null,"c","Empty","S1004","S1022","S1038","S1049","S1067","S1080","S1092","S1105","S1122","S1141","Empty"]
[{"$nulls":3},"Veliparib (ABT-888)","Ridaforolimus (Deforolimus, MK-8669)","PI-103","Y-27632 2HCl","SB431542","SU11274","KU-55933 (ATM Kinase Inhibitor)","LY294002","Mocetinostat (MGCD0103)","Tanespimycin (17-AAG)"]
[null,"d","Empty","S1006","S1025","S1039","S1052","S1068","S1082","S1093","S1106","S1124","S1142","Empty"]
[{"$nulls":3},"Saracatinib (AZD0530)","Gefitinib (ZD1839)","Rapamycin (AY-22989)","Elesclomol (STA-4783)","Crizotinib (PF-02341066)","Vismodegib (GDC-0449)","GSK1904529A","OSU-03012 (AR-12)","BMS-754807","Alvespimycin (17-DMAG) HCl"]
[null,"e","Empty","S1007","S1026","S1040","S1053","S1069","S1084","S1095","S1107","S1129","S1143","Empty"]
[{"$nulls":3},"Roxadustat (FG-4592)","Imatinib (STI571) Mesylate","Sorafenib (BAY 43-9006) tosylate","Entinostat (MS-275)","Luminespib (NVP-AUY922)","Brivanib (BMS-540215)","Dacinostat (LAQ824)","Danusertib (PHA-739358)","SRT1720 HCl","AG-490 (Tyrphostin B42)"]
[null,"f","Empty","S1012","S1028","S1041","S1055","S1072","S1085","S1096","S1109","S1130","S1145","Empty"]
[{"$nulls":3},"BMS-536924","Lapatinib (GW-572016) Ditosylate","STF-62247","Enzastaurin (LY317615)","ZSTK474","Belinostat (PXD101)","Quisinostat (JNJ-26481585) 2HCl","BI 2536","Sepantronium Bromide","SNS-032 (BMS-387032)"]
[null,"g","Empty","S1013","S1030","S1042","S1057","S1075","S1087","S1098","S1113","S1132","S1147","Empty"]
[{"$nulls":3},"Bortezomib (PS-341)","Panobinostat (LBH589)","Sunitinib (SU11248) malate","Obatoclax Mesylate (GX15-070)","SB216763","Iniparib (BSI-201)","Rucaparib (AG-014699) phosphate","GSK690693","3-Aminobenzamide","Barasertib (AZD1152-HQPA)"]
[null,"h","Empty","S1014","S1033","S1044","S1060","S1076","S1088","S1100","S1115","S1133","S1148","Empty"]
[{"$nulls":3},"Bosutinib (SKI-606)","Nilotinib (AMN-107)","Temsirolimus (CCI-779)","Olaparib (AZD2281)","Adezmapimod (SB203580)","NVP-ADW742","MLN8054","Odanacatib (MK-0822)","Alisertib (MLN8237)","Docetaxel (RP56976)"]
[]
[]
[]
[null,"Plate layout: L6200-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1150","S1165","S1178","S1192","S1208","S1219","S1230","S1243","S1262","S1289","Empty"]
[{"$nulls":3},"Paclitaxel (NSC 125973)","ABT-751 (E7010)","Regorafenib (BAY 73-4506)","Raltitrexed","Doxorubicin (Adriamycin) HCl","YM201636","Flavopiridol (L86-8275)","Agomelatine (S20098)","Avagacestat (BMS-708163)","Carmofur"]
[null,"b","Empty","S1153","S1168","S1180","S1193","S1209","S1221","S1231","S1244","S1263","S1290","Empty"]
[{"$nulls":3},"Roscovitine (CYC202)","Valproic Acid (NSC 93819) sodium salt","XAV-939","Thalidomide (K17)","Fluorouracil (5-Fluorouracil, 5-FU)","Dacarbazine (NSC-45388)","Topotecan (NSC609699) HCl","Amuvatinib (MP-470)","Laduviglusib (CHIR-99021)","Celastrol (NSC 70931)"]
[null,"c","Empty","S1154","S1169","S1181","S1194","S1210","S1222","S1233","S1245","S1266","S1292","Empty"]
[{"$nulls":3},"SNS-314","TGX-221","ENMD-2076","CUDC-101","Methotrexate (CL-14377)","Dexrazoxane HCl (ICRF-187)","2-Methoxyestradiol (2-MeOE2)","Latrepirdine 2HCl","WYE-354","Chelerythrine Chloride (NSC 646662)"]
[null,"d","Empty","S1155","S1171","S1183","S1197","S1212","S1223","S1234","S1249","S1267","S1294","Empty"]
[{"$nulls":3},"S3I-201","CYC116","Danoprevir (ITMN-191)","Finasteride","Bendamustine (SDX105) HCl","Epirubicin (IMI 28) HCl","AG-1024","JNJ-7706621","Vemurafenib (PLX4032)","Cilostazol (OPC-13013)"]
[null,"e","Empty","S1156","S1172","S1185","S1199","S1213","S1225","S1235","S1250","S1274","S1297","Empty"]
[{"$nulls":3},"Capecitabine (RO 09-1978)","Serdemetan (JNJ-26854165)","Ritonavir (ABT-538)","Cladribine (RWJ 26251)","Nelarabine","Etoposide (VP-16)","Letrozole (CGS 20267)","Enzalutamide (MDV3100)","BX-795","Epothilone A"]
[null,"f","Empty","S1157","S1175","S1186","S1200","S1214","S1226","S1237","S1251","S1275","S1299","Empty"]
[{"$nulls":3},"Delanzomib (CEP-18770)","BIIB021","BIBR 1532","Decitabine (NSC 127716)","Bleomycin (NSC125066) sulfate","KU-0063794","Temozolomide (CCRG 81045)","Dienogest","BX-912","Floxuridine (NSC 27640)"]
[null,"g","Empty","S1159","S1176","S1190","S1202","S1216","S1227","S1238","S1255","S1278","S1300","Empty"]
[{"$nulls":3},"Ganetespib (STA-9090)","Plinabulin (NPI-2358)","Bicalutamide (ICI-176334)","Dutasteride","PFI-1 (PF-6405761)","Raloxifene HCl","Tamoxifen (ICI 46474)","Nepafenac","Altretamine","Tegafur (FT-207)"]
[null,"h","Empty","S1163","S1177","S1191","S1204","S1218","S1229","S1241","S1261","S1282","S1302","Empty"]
[{"$nulls":3},"Onalespib (AT13387)","PD98059","Fulvestrant (ICI-182780)","Melatonin (NSC 113928)","Clofarabine","Fludarabine Phosphate","Vincristine (NSC-67574) sulfate","Celecoxib (SC 58635)","Artemisinin","Ifosfamide (NSC109724)"]
[]
[]
[]
[null,"Plate layout: L6200-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1305","S1342","S1368","S1396","S1438","S1462","S1485","S1524","S1541","S1574","Empty"]
[{"$nulls":3},"Mercaptopurine (6-MP)","Genistein (NPI 031L)","Acitretin","Resveratrol (SRT501)","Topiramate","AZD6482","HMN-214","AT7519","Selisistat (EX 527)","Doramapimod (BIRB 796)"]
[null,"b","Empty","S1319","S1344","S1369","S1398","S1445","S1465","S1487","S1525","S1547","S1576","Empty"]
[{"$nulls":3},"Costunolide","Glimepiride","Bafetinib (INNO-406)","Stavudine (d4T)","Zonisamide","Moxifloxacin (BAY12-8039) HCl","PHA-793887","Adavosertib (MK-1775)","Febuxostat","Sulfasalazine (NSC 667219)"]
[null,"c","Empty","S1322","S1351","S1373","S1400","S1451","S1467","S1489","S1526","S1555","S1582","Empty"]
[{"$nulls":3},"Dexamethasone (MK-125)","Ivermectin (MK-933)","Daptomycin (LY146032)","Tenofovir (GS 1278) Disoproxil Fumarate","Aurora A Inhibitor I (TC-S 7010)","Doxercalciferol","PIK-93","Quizartinib (AC220)","AZD8055","H 89 2HCl"]
[null,"d","Empty","S1324","S1352","S1378","S1401","S1452","S1474","S1490","S1528","S1556","S1590","Empty"]
[{"$nulls":3},"Doxazosin Mesylate","TG100-115","Ruxolitinib (INCB018424)","Tenofovir","Ispinesib (SB-715992)","GSK429286A","Ponatinib (AP24534)","LY2811376","PHT-427","TWS119"]
[null,"e","Empty","S1328","S1354","S1380","S1403","S1454","S1476","S1491","S1529","S1558","S1593","Empty"]
[{"$nulls":3},"Etodolac","Lansoprazole","Lopinavir (ABT-378)","Tigecycline (GAR-936)","PHA-680632","SB525334","Fludarabine (NSC 118218)","Hesperadin","AT7867","Apixaban (BMS 562247-01)"]
[null,"f","Empty","S1333","S1357","S1386","S1422","S1457","S1480","S1497","S1532","S1570","S1594","Empty"]
[{"$nulls":3},"Fluoxetine (Lilly 110140) HCl","Lidocaine","Nafamostat mesilate (FUT-175)","Droxinostat","Atazanavir (BMS-232632) Sulfate","Lomibuvir (VX-222)","Pralatrexate (NSC 754230)","AZD7762","KU-60019","Semagacestat (LY450139)"]
[null,"g","Empty","S1334","S1364","S1389","S1425","S1458","S1482","S1515","S1538","S1572","S1620","Empty"]
[{"$nulls":3},"Flupirtine maleate","Patupilone (Epothilone B)","Omeprazole","Ranolazine 2HCl","Neflamapimod (VX-745)","Daclatasvir (BMS-790052)","Pracinostat (SB939)","Telaprevir (VX-950)","BS-181 HCl","Darunavir Ethanolate"]
[null,"h","Empty","S1340","S1367","S1393","S1431","S1459","S1484","S1523","S1540","S1573","S1626","Empty"]
[{"$nulls":3},"Gatifloxacin","Amonafide","Pirarubicin (NSC-333054)","Sildenafil Citrate","Thiazovivin","MC1568","Voxtalisib (XL765) Analogue","Saxagliptin (BMS-477118)","Fasudil (HA-1077) HCl","Naproxen Sodium"]
[]
[]
[]
[null,"Plate layout: L6200-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1627","S1647","S1679","S1714","S1744","S1764","S1787","S1820","S1849","S1907","Empty"]
[{"$nulls":3},"Nitazoxanide (NSC 697855)","Adenosine","Flurbiprofen","Gemcitabine (LY-188011)","Nicotinic Acid","Rifampin (NSC-113926)","Teniposide","Clofibrate","Daidzein","Metronidazole"]
[null,"b","Empty","S1629","S1652","S1681","S1716","S1747","S1773","S1790","S1825","S1878","S1909","Empty"]
[{"$nulls":3},"Orlistat (Ro 18-0647)","Monobenzone","Mesalamine (5-ASA)","Glyburide (Glibenclamide)","Nimodipine","Oxytetracycline (Terramycin)","Rifaximin","Erdosteine","Ganciclovir (BW 759)","Fluvastatin (XU-62-320) Sodium"]
[null,"c","Empty","S1630","S1653","S1692","S1723","S1748","S1774","S1792","S1830","S1885","S1914","Empty"]
[{"$nulls":3},"Allopurinol","Tretinoin (NSC 122758)","Busulfan (NSC-750)","Indomethacin (NSC-77541)","Nisoldipine","Thioguanine (NSC 752)","Simvastatin (MK 733)","Oxfendazole","Felodipine","Pregnenolone"]
[null,"d","Empty","S1631","S1654","S1693","S1729","S1756","S1775","S1794","S1831","S1896","S1933","Empty"]
[{"$nulls":3},"Allopurinol Sodium","Phenylbutazone","Carbamazepine","Gemfibrozil","Enoxacin","Thiotepa","Fenofibrate (NSC-281319)","Carvedilol","Hydroxyurea (NSC-32065)","Triamcinolone"]
[null,"e","Empty","S1638","S1655","S1696","S1734","S1759","S1778","S1801","S1835","S1897","S1937","Empty"]
[{"$nulls":3},"Ibuprofen (NSC 256857)","Ezetimibe (SCH-58235)","Hydrocortisone (NSC 10483)","Meloxicam","Pitavastatin (NK-104) calcium","Trifluridine (NSC 75520)","Ranitidine Hydrochloride","Azithromycin (CP-62993)","Potassium Iodide","Isoniazid"]
[null,"f","Empty","S1639","S1657","S1703","S1736","S1760","S1782","S1802","S1840","S1899","S1940","Empty"]
[{"$nulls":3},"Amprenavir (VX-478)","Enalaprilat Dihydrate","Divalproex Sodium","Methocarbamol","Rifapentine","Azacitidine (5-Azacytidine)","AICAR (Acadesine)","Lomustine","Nicotinamide (NSC 13128)","Levofloxacin"]
[null,"g","Empty","S1645","S1662","S1712","S1738","S1761","S1784","S1805","S1847","S1903","S1949","Empty"]
[{"$nulls":3},"Ketoprofen","Isradipine","Deferasirox (ICL-670)","Telmisartan","Suprofen","Vidarabine","Acetylcholine Chloride","Clemastine (HS-592) fumarate","Diclofenac Sodium","Menadione (NSC 4170)"]
[null,"h","Empty","S1646","S1677","S1713","S1739","S1762","S1786","S1808","S1848","S1905","S1950","Empty"]
[{"$nulls":3},"Ketorolac","Chloramphenicol","Piroxicam","Thiabendazole","Pyrazinamide","Verteporfin (CL 318952)","Nifedipine (BAY-a-1040)","Curcumin","Amlodipine","Metformin HCl"]
[]
[]
[]
[null,"Plate layout: L6200-05"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1952","S1990","S2029","S2060","S2111","S2162","S2182","S2214","S2227","S2247","Empty"]
[{"$nulls":3},"Methoxsalen","Capsaicin(Vanilloid)","Uridine","Bromhexine HCl","Lapatinib (GW-572016)","AZD1480","SB743921 HCl","AZ 960","PIK-294","Buparlisib (BKM120)"]
[null,"b","Empty","S1959","S1994","S2032","S2062","S2113","S2163","S2186","S2215","S2228","S2248","Empty"]
[{"$nulls":3},"Tolfenamic Acid","Lacidipine","Rebamipide","Tiopronin","Cisatracurium Besylate","PF-4708671","SB505124","DAPT (GSI-IX)","Belnacasan (VX-765)","Silmitasertib (CX-4945)"]
[null,"c","Empty","S1960","S2006","S2040","S2064","S2114","S2169","S2193","S2217","S2230","S2250","Empty"]
[{"$nulls":3},"Pranoprofen","Pyrimethamine","Nimesulide","Balofloxacin","Dronedarone HCl","Rosuvastatin (ZD4522) calcium","GSK461364","Irinotecan (CPT-11) HCl Trihydrate","Galunisertib (LY2157299)","(-)-Epigallocatechin Gallate"]
[null,"d","Empty","S1972","S2007","S2043","S2077","S2131","S2170","S2195","S2218","S2235","S2252","Empty"]
[{"$nulls":3},"Tamoxifen (ICI 46474) Citrate","Sulindac","Memantine HCl","Atorvastatin Calcium","Roflumilast (B9302-107)","Givinostat (ITF2357)","Lexibulin (CYT997)","Torkinib (PP242)","Volasertib (BI 6727)","(+)-Usniacin"]
[null,"e","Empty","S1973","S2011","S2045","S2098","S2151","S2178","S2197","S2219","S2238","S2254","Empty"]
[{"$nulls":3},"Cyclocytidine HCl","Pramipexole 2HCl Monohydrate","Doxifluridine","Bexarotene (LGD1069)","Sonidegib (NVP-LDE225)","AG-14361","A-966492","Momelotinib (CYT387)","Palomid 529 (P529)","4-Demethylepipodophyllotoxin(NSC-122819,VM-26)"]
[null,"f","Empty","S1979","S2012","S2046","S2101","S2156","S2179","S2198","S2224","S2243","S2258","Empty"]
[{"$nulls":3},"Amiodarone (NSC 85442) HCl","PCI-34051","Pioglitazone HCl","Gabexate Mesylate","LY2886721","Gandotinib (LY2784544)","SGI-1776 free base","UK 383367","Degrasyn (WP1130)","Esculin"]
[null,"g","Empty","S1983","S2014","S2053","S2102","S2158","S2180","S2199","S2225","S2244","S2259","Empty"]
[{"$nulls":3},"Adenine HCl","BMS-265246","Cytidine","Rasagiline Mesylate","KW-2449","Ixazomib (MLN2238)","Aliskiren Hemifumarate","TAME","AR-42","Aloe-emodin"]
[null,"h","Empty","S1988","S2018","S2057","S2108","S2161","S2181","S2207","S2226","S2246","S2261","Empty"]
[{"$nulls":3},"Propylthiouracil","ENMD-2076 L-(+)-Tartaric acid","Cyclophosphamide (NSC-26271) Monohydrate","Flunixin Meglumin","RAF265 (CHIR-265)","Ixazomib Citrate (MLN9708) Analogue","PIK-293","Idelalisib","Abiraterone Acetate (CB7630)","Andrographolide"]
[]
[]
[]
[null,"Plate layout: L6200-06"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2262","S2280","S2298","S2314","S2328","S2338","S2350","S2370","S2391","S2406","Empty"]
[{"$nulls":3},"Apigenin (LY 080400)","Chlorogenic Acid","Fisetin","Kaempferol (NSC 407289)","Nalidixic acid","Oxymatrine","Rutin","Ursolic Acid","Quercetin (NSC 9221)","Chrysophanic Acid"]
[null,"b","Empty","S2263","S2281","S2301","S2316","S2329","S2339","S2351","S2371","S2394","S2407","Empty"]
[{"$nulls":3},"Arbutin","Chrysin","Genistin (Genistoside)","Kinetin","Naringin","Paeonol","Salicin","Vanillylacetone","Naringenin","Curcumol"]
[null,"c","Empty","S2265","S2284","S2302","S2320","S2331","S2341","S2354","S2375","S2396","S2408","Empty"]
[{"$nulls":3},"Artesunate (WR-256283)","Colchicine (NSC 757)","Glycyrrhizin (NSC 167409)","Luteolin","Neohesperidin Dihydrochalcone (Nhdc)","(-)-Parthenolide","Sclareol","Aloin","Salidroside","Cephalomannine"]
[null,"d","Empty","S2266","S2285","S2308","S2321","S2332","S2342","S2357","S2379","S2399","S2410","Empty"]
[{"$nulls":3},"Asiatic Acid","Cryptotanshinone","Hesperetin","Magnolol","Neohesperidin","Phloretin (RJC 02792)","Silibinin (NSC 651520)","Dioscin","Dihydromyricetin","Paeoniflorin (NSC 178886)"]
[null,"e","Empty","S2268","S2289","S2309","S2322","S2333","S2344","S2358","S2380","S2400","S2411","Empty"]
[{"$nulls":3},"Baicalein","Daidzin","Hesperidin","(+)-Matrine","Nobiletin (NSC 76751)","Piperine","Silymarin","Diosmetin","Rheic Acid","Geniposide"]
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[{"$nulls":3},"Baicalin (NSC-661431)","Dihydroartemisinin (DHA)","Honokiol (NSC 293100)","Morin Hydrate","Oleanolic Acid","Quercetin Dihydrate","Tangeretin","Evodiamine","Sodium Danshensu","Astragaloside A"]
[null,"g","Empty","S2270","S2293","S2312","S2326","S2335","S2348","S2365","S2386","S2404","S2423","Empty"]
[{"$nulls":3},"Bergenin","DL-Carnitine HCl","Icariin","Myricetin","Oridonin (NSC-250682)","Rotenone (Barbasco)","Tanshinone IIA","Indirubin (NSC 105327)","Isoliquiritigenin","(S)-10-Hydroxycamptothecin"]
[null,"h","Empty","S2271","S2295","S2313","S2327","S2336","S2349","S2369","S2389","S2405","S2425","Empty"]
[{"$nulls":3},"Berberine chloride (NSC 646666)","Emodin","Indole-3-carbinol","Myricitrin","Orotic acid (6-Carboxyuracil)","Rutaecarpine","Troxerutin","Naringin Dihydrochalcone","Sophocarpine","Apocynin (NSC 2146)"]
[]
[]
[]
[null,"Plate layout: L6200-07"]
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[null,"a","Empty","S2443","S2491","S2531","S2579","S2606","S2631","S2662","S2683","S2697","S2719","Empty"]
[{"$nulls":3},"Tolbutamide (HLS 831)","Nitrendipine","Asaraldehyde","Zidovudine","Mifepristone (RU486)","URB597","Foscenvivint (ICG-001)","CHIR-124","A-769662","AMG-900"]
[null,"b","Empty","S2448","S2492","S2532","S2584","S2610","S2635","S2665","S2685","S2699","S2726","Empty"]
[{"$nulls":3},"Gambogic Acid","Novobiocin Sodium (NSC 2382)","L-Ascorbyl 6-palmitate","Clobetasol propionate","Lonidamine (AF-1890)","CCT128930","Ciprofibrate","KW-2478","CH5132799","PH-797804"]
[null,"c","Empty","S2449","S2493","S2553","S2586","S2619","S2636","S2670","S2686","S2700","S2729","Empty"]
[{"$nulls":3},"Colforsin","Olanzapine","5-Aminolevulinic acid HCl","Dimethyl Fumarate","MG132","A66","A-674563","NVP-BSK805 2HCl","Tirbanibulin","SB415286"]
[null,"d","Empty","S2450","S2505","S2554","S2590","S2621","S2639","S2671","S2688","S2703","S2730","Empty"]
[{"$nulls":3},"Equol","Rosiglitazone (BRL-49653) maleate","Daphnetin","Pioglitazone (AD-4833)","AZD5438","SNX-2112 (PF-04928473)","AS-252424","R547","GSK1838705A","Crenolanib (CP-868596)"]
[null,"e","Empty","S2458","S2512","S2555","S2593","S2622","S2656","S2673","S2689","S2711","S2731","Empty"]
[{"$nulls":3},"Clonidine HCl","Tenoxicam","Clarithromycin","Tolvaptan","PP121","PF-04929113 (SNX-5422)","Trametinib (GSK1120212)","WAY-600","Dibenzazepine (YO-01027)","AZ 3146"]
[null,"f","Empty","S2475","S2517","S2556","S2602","S2624","S2658","S2679","S2692","S2713","S2736","Empty"]
[{"$nulls":3},"Imatinib (STI571)","Maprotiline HCl","Rosiglitazone (BRL 49653)","Acemetacin","OSI-027","Omipalisib (GSK2126458)","Flavopiridol (L86-8275) HCl","TG101209","Geldanamycin (NSC 122750)","Fedratinib (TG101348)"]
[null,"g","Empty","S2480","S2526","S2557","S2603","S2626","S2660","S2681","S2693","S2714","S2738","Empty"]
[{"$nulls":3},"Loperamide HCl","Alizarin","Terbinafine HCl","Tioxolone","Rabusertib (LY2603618)","MK-0752","AS-604850","Resminostat","LY411575","PAC-1"]
[null,"h","Empty","S2485","S2528","S2577","S2605","S2627","S2661","S2682","S2696","S2718","S2740","Empty"]
[{"$nulls":3},"Mitoxantrone (NSC-301739) 2HCl","Ciclopirox","Phenacetin","Idebenone","Tubastatin A HCl","WYE-125132 (WYE-132)","CAY10505","Apitolisib (GDC-0980)","TAK-901","GSK1070916"]
[]
[]
[]
[null,"Plate layout: L6200-08"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2741","S2754","S2779","S2796","S2812","S2843","S2867","S2907","S2926","S3012","Empty"]
[{"$nulls":3},"Niraparib (MK-4827)","Xevinapant (AT406)","M344","WP1066","(R)-(-)-Gossypol acetic acid","BI-D1870","WHI-P154","Pirfenidone (S-7701)","TDZD-8","Pazopanib"]
[null,"b","Empty","S2742","S2757","S2780","S2797","S2814","S2847","S2868","S2910","S2928","S3017","Empty"]
[{"$nulls":3},"PHA-767491 HCl","Evofosfamide (TH-302)","I-BET151 (GSK1210151A)","Lonafarnib (SCH66336)","Alpelisib (BYL719)","Cathepsin Inhibitor 1","Alogliptin (SYR-322) benzoate","Tempol","TAK-715","Aspirin (NSC 27223)"]
[null,"c","Empty","S2743","S2759","S2781","S2799","S2817","S2851","S2871","S2911","S2929","S3018","Empty"]
[{"$nulls":3},"PF-04691502","Fimepinostat (CUDC-907)","RITA (NSC 652287)","Daporinad","Torin 2","Baricitinib (INCB028050)","T0070907","Go 6983","Pifithrin-α (PFTα) HBr","Niflumic acid"]
[null,"d","Empty","S2745","S2768","S2783","S2803","S2818","S2853","S2874","S2913","S2930","S3022","Empty"]
[{"$nulls":3},"CHIR-98014","Dinaciclib (SCH727965)","Vistusertib (AZD2014)","Galeterone","Tacedinaline (CI994)","Carfilzomib (PR-171)","Camostat Mesilate","BAY 11-7082","Pifithrin-μ","Cabazitaxel (XRP6258)"]
[null,"e","Empty","S2747","S2770","S2787","S2804","S2820","S2858","S2882","S2914","S3001","S3023","Empty"]
[{"$nulls":3},"AMG-458","MK-5108 (VX-689)","Laquinimod","Sirtinol","TAE226 (NVP-TAE226)","StemRegenin 1 (SR1)","IKK-16 (IKK Inhibitor VII)","Dapivirine (TMC120)","Clevudine","Bufexamac"]
[null,"f","Empty","S2749","S2775","S2789","S2806","S2821","S2863","S2898","S2915","S3002","S3024","Empty"]
[{"$nulls":3},"BGT226 (NVP-BGT226) maleate","Nocodazole (R17934)","Tofacitinib (CP-690550)","CEP-33779","RG108","Nodinitib-1","MLN0905","GW9662","Rivaroxaban (BAY 59-7939)","Lamotrigine"]
[null,"g","Empty","S2750","S2776","S2791","S2808","S2823","S2864","S2902","S2919","S3005","S3025","Empty"]
[{"$nulls":3},"GW788388","Devimistat (CPI-613)","Sotrastaurin (AEB071)","Ipatasertib (GDC-0068)","Tideglusib (NP031112)","IMD 0354","S-Ruxolitinib (INCB018424)","IOX2","Paroxetine HCl","PMSF"]
[null,"h","Empty","S2751","S2777","S2794","S2811","S2824","S2866","S2903","S2924","S3008","S3026","Empty"]
[{"$nulls":3},"Milciclib (PHA-848125)","PF-5274857","Sofosbuvir (GS-7977)","Sapanisertib (MLN0128)","TPCA-1","U-104","Lumiracoxib","Laduviglusib (CHIR-99021) HCl","Zaltoprofen","Piceatannol"]
[]
[]
[]
[null,"Plate layout: L6200-09"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3027","S3063","S3137","S3600","S3615","S3633","S3659","S3675","S3698","S3733","Empty"]
[{"$nulls":3},"Fenoprofen calcium hydrate","Diclofenac Diethylamine","Sodium salicylate","Schisandrin B (Sch B)","Dehydrocostus Lactone","Pyrrolidinedithiocarbamate ammonium","Fludrocortisone acetate","Umbelliferone","Nortriptyline hydrochloride","Boceprevir"]
[null,"b","Empty","S3030","S3077","S3138","S3603","S3616","S3639","S3660","S3679","S3719","S3756","Empty"]
[{"$nulls":3},"Niclosamide (BAY2353)","Tazobactam","Methylthiouracil","Betulinic acid","Asiaticoside","Tacrine hydrochloride hydrate","Uniconazole (S 3307D)","Flavanone","Topiroxostat","Methyl salicylate"]
[null,"c","Empty","S3031","S3079","S3147","S3604","S3617","S3647","S3661","S3681","S3720","S3758","Empty"]
[{"$nulls":3},"Linagliptin (BI-1356)","Atovaquone","Entacapone","Triptolide (PG490)","(20S)-Protopanaxatriol","Mafenide Acetate","2-Methoxy-1,4-naphthoquinone","Vitamin E Acetate","Elafibranor","Sinomenine hydrochloride"]
[null,"d","Empty","S3033","S3113","S3154","S3609","S3624","S3648","S3665","S3688","S3722","S3764","Empty"]
[{"$nulls":3},"Vildagliptin (LAF-237)","Pyridoxine HCl","Butenafine HCl","Berbamine dihydrochloride","Quinolinic acid","Amlexanox (AA-673)","Trolox","2,4-Diamino-6-hydroxypyrimidine","Isavuconazole","Isoferulic Acid"]
[null,"e","Empty","S3035","S3114","S3173","S3610","S3626","S3652","S3666","S3690","S3724","S3765","Empty"]
[{"$nulls":3},"Daunorubicin (RP 13057) HCl","Vitamin C","Antipyrine","Cordycepin","Sesamol","3-Nitropropionic acid","Ilaprazole","Pargyline hydrochloride","Velpatasvir","Picroside II"]
[null,"f","Empty","S3043","S3120","S3178","S3611","S3628","S3653","S3669","S3692","S3725","S3769","Empty"]
[{"$nulls":3},"Rofecoxib","Doxepin HCl","Brinzolamide","(+)-Fangchinoline","BHQ","Spermidine trihydrochloride","Carmustine","N-Ethylmaleimide (NEM)","ELR-510444","Palmatine"]
[null,"g","Empty","S3052","S3124","S3181","S3612","S3629","S3654","S3671","S3694","S3728","S3771","Empty"]
[{"$nulls":3},"Rupatadine Fumarate","Dexamethasone Acetate","Flumequine","Rosmarinic acid","Syringic acid","Tauroursodeoxycholic Acid (TUDCA)","Quinestrol","Glucosamine hydrochloride","Grazoprevir","Stachydrine"]
[null,"h","Empty","S3062","S3129","S3200","S3613","S3630","S3658","S3673","S3697","S3731","S3773","Empty"]
[{"$nulls":3},"Diclofenac Potassium","Trimethoprim","Triflusal","Scoparone","Methyl Vanillate","O6-Benzylguanine","Sulfaphenazole","Mafenide hydrochloride","Tipiracil hydrochloride","Tyrosol"]
[]
[]
[]
[null,"Plate layout: L6200-10"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3775","S3787","S3804","S3817","S3829","S3839","S3857","S3871","S3884","S3903","Empty"]
[{"$nulls":3},"Ligustrazine hydrochloride","Picroside I","Alpha-Mangostin","Harmine hydrochloride","Isoalantolactone","1-Deoxynojirimycin","4-Hydroxybenzyl alcohol","Muscone","Jatrorrhizine","Lycorine"]
[null,"b","Empty","S3777","S3788","S3807","S3818","S3832","S3840","S3859","S3872","S3885","S3905","Empty"]
[{"$nulls":3},"Gentiopicroside","Carvacrol","Dehydroandrographolide","Tectoridin","Euphorbiasteroid","Baohuoside I","Vanillyl Alcohol","Guaiacol","Pyrogallol","Iso-Steviol"]
[null,"c","Empty","S3780","S3790","S3808","S3819","S3833","S3842","S3860","S3874","S3888","S3906","Empty"]
[{"$nulls":3},"Secoisolariciresinol diglucoside","Methyl gallate","Mangiferin","Decursinol angelate","Amentoflavone","Isoquercitrin","Allicin","Curcumenol","3,4',5-Trimethoxy-trans-stilbene","Astragalus polyphenols"]
[null,"d","Empty","S3781","S3792","S3810","S3822","S3834","S3843","S3862","S3875","S3894","S3909","Empty"]
[{"$nulls":3},"Ginkgolide C","Guggulsterone E&Z","Scutellarin","Schisandrin A","Astaxanthin","Madecassoside","Gallic acid trimethyl ether","Alpinetin","Cycloastragenol","Catalpol"]
[null,"e","Empty","S3783","S3794","S3811","S3823","S3835","S3846","S3867","S3879","S3897","S3915","Empty"]
[{"$nulls":3},"Echinacoside","Palmitic acid","Ginsenoside Re","Schizandrol A","Loganin","Eupatilin","(E)-Cardamonin","Kaempferide","(-)-Arctigenin","Gracillin"]
[null,"f","Empty","S3784","S3799","S3813","S3824","S3836","S3848","S3868","S3880","S3898","S3917","Empty"]
[{"$nulls":3},"Obacunone (AI3-37934)","Gentisic acid","Bakuchiol","Quercitrin","6-Gingerol","Hydroxytyrosol Acetate","Harmine","Schisantherin A","Hydroxy Camptothecine","Tetrahydrocurcumin"]
[null,"g","Empty","S3785","S3800","S3815","S3826","S3837","S3849","S3869","S3881","S3899","S3922","Empty"]
[{"$nulls":3},"Notoginsenoside R1","Lycorine hydrochloride","Mogroside V","Hydroxytyrosol","Echinocystic acid","D-Galactose","Methyl protocatechuate","Scopoletin","Hederagenin","(-)-epigallocatechin"]
[null,"h","Empty","S3786","S3802","S3816","S3828","S3838","S3855","S3870","S3883","S3901","S3923","Empty"]
[{"$nulls":3},"Glabridin","Trigonelline Hydrochloride","Dehydroevodiamine","Orcinol glucoside","Carnosic acid","Ethyl ferulate","D-Pinitol","Protopine","Astragaloside IV","Ginsenoside Rg1"]
[]
[]
[]
[null,"Plate layout: L6200-11"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S3924","S3937","S3967","S3993","S4049","S4098","S4136","S4182","S4223","S4261","Empty"]
[{"$nulls":3},"Ginsenoside Rb1","Pterostilbene","Flavone","Ethyl Vanillate","Valdecoxib","Halcinonide","Carprofen","Nifuroxazide","Mevastatin","EUK 134"]
[null,"b","Empty","S3925","S3938","S3969","S3996","S4051","S4100","S4149","S4188","S4227","S4263","Empty"]
[{"$nulls":3},"(-)-Epicatechin gallate","Bisdemethoxycurcumin (BDMC)","Veratric acid","Thioctic acid","Nabumetone","Esmolol HCl","Amfenac Sodium Monohydrate","Sasapyrine","Fidaxomicin","Efaproxiral Sodium"]
[null,"c","Empty","S3926","S3940","S3970","S3998","S4054","S4114","S4151","S4194","S4230","S4268","Empty"]
[{"$nulls":3},"Forsythin","3'-Hydroxypterostilbene","Vindoline","(+)-α-Lipoic acid","Spironolactone","Triclabendazole","Penfluridol","Azaguanine-8","Oxaprozin","Flufenamic acid"]
[null,"d","Empty","S3930","S3941","S3974","S4002","S4059","S4118","S4155","S4198","S4238","S4269","Empty"]
[{"$nulls":3},"Liquiritin","Pinocembrin","(+)-Catechin hydrate","Sitagliptin phosphate monohydrate","Sodium Nitroprusside Dihydrate","Histamine 2HCl","Chlorzoxazone","Aminothiazole","Cepharanthine","Vinorelbine ditartrate (KW-2307)"]
[null,"e","Empty","S3931","S3944","S3975","S4003","S4073","S4119","S4159","S4202","S4239","S4280","Empty"]
[{"$nulls":3},"Ginsenoside Rd","Valproic acid (VPA)","Protocatechuic acid","Lithocholic acid","Sodium 4-Aminosalicylate","Pefloxacin Mesylate Dihydrate","Bezafibrate","Verapamil (CP-16533-1) HCl","Bergapten","Meclofenoxate (Centrophenoxine) HCl"]
[null,"f","Empty","S3932","S3952","S3980","S4011","S4078","S4125","S4163","S4206","S4246","S4282","Empty"]
[{"$nulls":3},"Astilbin","3,4-Dihydroxybenzaldehyde","Pyridoxine","Ampiroxicam","Mefenamic Acid","Sodium Phenylbutyrate","Doxycycline Hyclate (WC2031)","Cysteamine HCl","Tranylcypromine (2-PCPA) HCl","Nelfinavir (AG 1343) Mesylate"]
[null,"g","Empty","S3933","S3956","S3981","S4017","S4081","S4128","S4176","S4207","S4248","S4288","Empty"]
[{"$nulls":3},"10-deacetyl-paclitaxel","Tetramethylpyrazine","Sinapinic Acid","Allylthiourea","Sulfacetamide Sodium","Troxipide","Trometamol","Clofibric Acid","Bromfenac Sodium","Chloroambucil"]
[null,"h","Empty","S3934","S3957","S3984","S4039","S4084","S4132","S4181","S4221","S4255","S4294","Empty"]
[{"$nulls":3},"Acetyl Resveratrol","Gamma-Oryzanol","Nordihydroguaiaretic acid (NDGA)","Methazolamide","Lomerizine 2HCl","Deoxyarbutin","Nicardipine HCl","Benzbromarone","Quinacrine 2HCl","Procainamide HCl"]
[]
[]
[]
[null,"Plate layout: L6200-12"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4295","S4420","S4527","S4571","S4612","S4662","S4701","S4723","S4746","S4765","Empty"]
[{"$nulls":3},"Meclofenamate Sodium","Mefloquine HCl","Fenofibric acid","Hexylresorcinol","Dapson","Atazanavir","2-Deoxy-D-glucose (2-DG)","(-)Epicatechin","(20S)-Protopanaxadiol","Syringaldehyde"]
[null,"b","Empty","S4297","S4504","S4539","S4576","S4628","S4666","S4706","S4725","S4747","S4766","Empty"]
[{"$nulls":3},"Mupirocin","6-Mercaptopurine (6-MP) Monohydrate","Salicylic acid","Sulfabenzamide","(+/-)-Sulfinpyrazone","Sivelestat sodium tetrahydrate","Eugenol","Benzenesulfonamide","Jervine","Gibberellic acid"]
[null,"c","Empty","S4309","S4505","S4541","S4589","S4630","S4667","S4709","S4731","S4749","S4771","Empty"]
[{"$nulls":3},"Bromocriptine Mesylate","Vinblastine (NSC-49842) sulfate","Triclosan","Amodiaquine dihydrochloride dihydrate","Diazoxide","Lidocaine hydrochloride","Latanoprost","Perphenazine","Citalopram HBr","β-thujaplicin"]
[null,"d","Empty","S4345","S4506","S4543","S4591","S4636","S4676","S4710","S4732","S4750","S4779","Empty"]
[{"$nulls":3},"Pentoxifylline","Acetazolamide","Trimetazidine dihydrochloride","Nitroxoline","Teneligliptin hydrobromide","Gluconolactone","Picolinamide","MPTP hydrochloride","Sulfacetamide sodium salt hydrate","Menadiol Diacetate"]
[null,"e","Empty","S4353","S4509","S4546","S4601","S4640","S4682","S4711","S4735","S4753","S4782","Empty"]
[{"$nulls":3},"Terfenadine","4-Aminoantipyrine","Xylitol","Clioquinol","Lesinurad","Loxoprofen","Esculetin","Salvianolic acid B","Ganoderic acid A","5-methoxyflavone"]
[null,"f","Empty","S4358","S4511","S4548","S4603","S4648","S4685","S4712","S4737","S4759","S4783","Empty"]
[{"$nulls":3},"Pimozide","6-Benzylaminopurine","Aminoguanidine hydrochloride","Gallic acid","Dantrolene sodium hemiheptahydrate","Efavirenz","Diethylmaleate","Psoralen","p-Coumaric Acid","Benzyl isothiocyanate"]
[null,"g","Empty","S4381","S4512","S4559","S4604","S4651","S4686","S4715","S4739","S4761","S4784","Empty"]
[{"$nulls":3},"Proadifen HCl","Aceglutamide","Cloxiquine","Levofloxacin hydrate","Etoricoxib","Vitamin E","Benzamide","Oxyresveratrol","Thymoquinone","Phloracetophenone"]
[null,"h","Empty","S4398","S4526","S4561","S4609","S4656","S4697","S4722","S4743","S4763","S4803","Empty"]
[{"$nulls":3},"Isoxicam","Fenbufen","Danthron","Diflunisal","Parecoxib","Saxagliptin hydrate","(+)-Catechin","Wogonin","4-Hydroxychalcone","Thymidine (NSC 21548)"]
[]
[]
[]
[null,"Plate layout: L6200-13"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4809","S4866","S4935","S4966","S5002","S5059","S5079","S5144","S5221","S5266","Empty"]
[{"$nulls":3},"3-Indolepropionic acid","Nicarbazin","Asunaprevir (BMS-650032)","4-Methylesculetin","Fingolimod (FTY720) HCl","Pixantrone Maleate","Sitagliptin","Neferine","Diludine","Stiripentol"]
[null,"b","Empty","S4831","S4900","S4937","S4970","S5003","S5060","S5104","S5157","S5229","S5284","Empty"]
[{"$nulls":3},"Piperonyl butoxide","Tenovin-6","4'-Hydroxychalcone","Nerol","Tacrolimus (FK506)","Metadoxine","Tea polyphenol","Thymol","Isosorbide dinitrate","Adenosine 5'-monophosphate monohydrate"]
[null,"c","Empty","S4832","S4902","S4938","S4977","S5006","S5062","S5105","S5159","S5233","S5293","Empty"]
[{"$nulls":3},"Tolmetin","QNZ (EVP4593)","Cedrol","Efonidipine","Teprenone","Daclatasvir Dihydrochloride","Proanthocyanidins","Doxycycline","Fenretinide (NSC 374551)","Nimustine Hydrochloride"]
[null,"d","Empty","S4835","S4904","S4940","S4981","S5010","S5063","S5111","S5162","S5242","S5297","Empty"]
[{"$nulls":3},"Aceclofenac","JZL184","Maltol","Cyclogalegenol","Indometacin Sodium","Trelagliptin succinate","7-Ethylcamptothecin","Isovanillic acid","Cediranib Maleate","Vidarabine monohydrate"]
[null,"e","Empty","S4849","S4907","S4941","S4990","S5015","S5065","S5113","S5174","S5243","S5304","Empty"]
[{"$nulls":3},"Levocetirizine Dihydrochloride","SC-514","Farnesol","TBHQ","Simeprevir (TMC435)","Ganciclovir sodium","Propyl gallate","Kojic acid","Ruxolitinib Phosphate","2-Acetylphenothiazine (ML171)"]
[null,"f","Empty","S4853","S4908","S4943","S4997","S5017","S5073","S5121","S5177","S5250","S5307","Empty"]
[{"$nulls":3},"Ecabet sodium","SN-38","Isovanillin","4-Butylresorcinol","Oxyclozanide","Donepezil","Phytol","Naproxen","Darunavir","PSI-6206 (GS-331007)"]
[null,"g","Empty","S4856","S4920","S4957","S4999","S5019","S5077","S5127","S5182","S5254","S5309","Empty"]
[{"$nulls":3},"Iproniazid","b-AP15","Linalool","Avermectin B1","Indobufen","Regorafenib (BAY-734506) Monohydrate","Spiculisporic Acid","GSK4112","Dasatinib hydrochloride","Propyphenazone (4-Isopropylantipyrine)"]
[null,"h","Empty","S4862","S4921","S4964","S5001","S5058","S5078","S5133","S5200","S5265","S5312","Empty"]
[{"$nulls":3},"Squalene","MNS (3,4-Methylenedioxy-β-nitrostyrene)","Lactobionic acid","Tofacitinib (CP-690550) Citrate","Revaprazan Hydrochloride","Osimertinib mesylate","Sodium erythorbate","Diaveridine","TBB","Urolithin A"]
[]
[]
[]
[null,"Plate layout: L6200-14"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5313","S5345","S5388","S5425","S5451","S5464","S5551","S5582","S5641","S5709","Empty"]
[{"$nulls":3},"SC66","(+/-)-nerolidol","Betrixaban","Phenylglyoxal hydrate","Ferulic acid methyl ester","Psoralidin","6-Paradol","Cytarabine hydrochloride","Rhodamine B","Norgestrel"]
[null,"b","Empty","S5314","S5357","S5389","S5426","S5452","S5465","S5552","S5595","S5648","S5710","Empty"]
[{"$nulls":3},"HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","Safinamide","Betrixaban maleate","Bromopyruvic acid","Sanguinarine chloride","Morroniside","Amenamevir","3-Carene","Iguratimod","Ambroxol"]
[null,"c","Empty","S5315","S5365","S5394","S5434","S5453","S5466","S5554","S5604","S5652","S5711","Empty"]
[{"$nulls":3},"PRT4165","Alogliptin","Tizoxanide","AS057278","Hyperoside","Saikosaponin A","Lanatoside C","Diphenylamine Hydrochloride","Elbasvir","Deracoxib"]
[null,"d","Empty","S5316","S5366","S5402","S5438","S5454","S5484","S5561","S5605","S5658","S5716","Empty"]
[{"$nulls":3},"NU2058","Fipronil","Dasabuvir (ABT-333)","Biphenyl-4-sulfonyl chloride","Saikosaponin D","Rimantadine Hydrochloride","Ethacrynic Acid","Tos-Arg-OMe HCl","Omeprazole Sodium","Abemaciclib (LY2835219)"]
[null,"e","Empty","S5317","S5369","S5403","S5439","S5456","S5502","S5563","S5616","S5686","S5720","Empty"]
[{"$nulls":3},"UK 5099","Ethoxyquin","Ombitasvir (ABT-267)","5-Bromoindole","Isobavachalcone","Ilaprazole sodium","Thioridazine hydrochloride","4-Methylcatechol","Tryptanthrin","Glecaprevir"]
[null,"f","Empty","S5318","S5373","S5404","S5440","S5457","S5520","S5565","S5623","S5688","S5742","Empty"]
[{"$nulls":3},"Acacetin","Pseudolaric Acid B","Paritaprevir (ABT-450)","Berberine Sulfate","Curculigoside","Phenidone","Triflupromazine hydrochloride","Bedaquiline","Tropolone (NSC 89303)","Deferoxamine mesylate (Ba 33112)"]
[null,"g","Empty","S5325","S5380","S5416","S5445","S5458","S5529","S5575","S5627","S5696","S5752","Empty"]
[{"$nulls":3},"Nitisinone","7-Hydroxyflavone","Metyrapone","AMI-1 (free acid)","Verbascoside","Galangin","2-Benzoxazolinone","Amsacrine hydrochloride","JNJ0966","Abametapir"]
[null,"h","Empty","S5343","S5383","S5418","S5450","S5460","S5550","S5579","S5640","S5698","S5754","Empty"]
[{"$nulls":3},"Vanillic acid","Erucic acid","Parecoxib Sodium","Sofalcone","Vitexin-2-O-rhaMnoside","Ethyl gallate","Chelidonic acid","Ethyl caffeate","Ketorolac tromethamine salt","Baricitinib phosphate"]
[]
[]
[]
[null,"Plate layout: L6200-15"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5759","S5810","S5832","S5909","S5927","S6073","S6221","S6414","S6494","S6521","Empty"]
[{"$nulls":3},"Methyl linoleate","UF010","Pyrrole-2-carboxylic acid","Anagliptin","Proguanil","Diclofenac acid","Methyl cinnamate","Apilimod (STA-5326)","CCCP","WHI-P258"]
[null,"b","Empty","S5767","S5811","S5834","S5913","S5928","S6088","S6229","S6420","S6495","S6524","Empty"]
[{"$nulls":3},"Aliskiren","Kevetrin hydrochloride","p-Coumaric acid ethyl ester","Cambinol","Zerumbone","6-(Dimethylamino)purine","Lauryl gallate","AGI 1067","6-Bromo-2-hydroxy-3-methoxybenzaldehyde","NSC 42834"]
[null,"c","Empty","S5771","S5812","S5840","S5914","S5929","S6104","S6254","S6422","S6497","S6533","Empty"]
[{"$nulls":3},"Sulforaphane","Choline Fenofibrate","Palifosfamide","AK 7","4-Octyl Itaconate","(±)-α-Tocopherol","Hydrocinnamic acid","Lazabemide","SMI-16a","Briciclib"]
[null,"d","Empty","S5772","S5815","S5841","S5915","S5933","S6111","S6256","S6426","S6498","S6536","Empty"]
[{"$nulls":3},"AS-8351","WAY-316606","DKM 2-93","OAC2","K 858","L-Hydroorotic acid","Isocytosine","Hesperidin methylchalcone","T56-LIMKi","TTP 22"]
[null,"e","Empty","S5774","S5816","S5842","S5916","S5950","S6125","S6338","S6441","S6503","S6537","Empty"]
[{"$nulls":3},"CY-09","Pyrvinium","Cabergoline","GSK 5959","Fingolimod","Glycerol trilinoleate","3,4-Dihydroxyhydrocinnamic acid","Riboflavin Tetrabutyrate","LX2343","CVT-313"]
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[{"$nulls":3},"Dronedarone","GSK0660","JANEX-1","Solcitinib","Disufenton sodium","Glycoursodeoxycholic acid","(+)-Delta-Tocopherol","Bicyclol","Compound 401","MTX-211"]
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[{"$nulls":3},"N-Acetylcysteine amide","Cinnamyl alcohol","Suberohydroxamic acid","CA-5f","2,3,4-Trihydroxybenzoic acid","Butylated hydroxytoluene","2-Aminoethanethiol","Tinoridine hydrochloride","GNE-477","JK184"]
[]
[]
[]
[null,"Plate layout: L6200-16"]
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[{"$nulls":3},"BQR695","Duvelisib (IPI-145)","CX-6258 HCl","GSK J4 HCl (GSKJ4 HCl)","SANT-1","AZD3463","P5091 (P005091)","NSC697923","C646","Crenigacestat (LY3039478)"]
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[{"$nulls":3},"KDU691","AZD2461","Brefeldin A","SGC 0946","IPA-3","(+)-JQ1","P22077","LGK-974","Batimastat (BB-94)","Setanaxib (GKT137831)"]
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[{"$nulls":3},"PKC-theta inhibitor","RG-7112","Oprozomib (ONX 0912)","Ceritinib (LDK378)","PF-3758309","Zebularine (NSC 309132)","IU1","BMS-911543","Marimastat (BB-2516)","SKI II"]
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[{"$nulls":3},"Longdaysin","GSK2656157","AZ20","IWR-1-endo","KY02111","Go6976","LDN-57444","AZD1080","Ilomastat","Molibresib (I-BET-762)"]
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[{"$nulls":3},"VS-5584 (SB2343)","Wnt-C59 (C59)","LY2090314","UNC1215","Berzosertib (VE-822)","TIC10 Analogue","GLPG0634 analogue","LDN-212854","Glasdegib (PF-04449913)","RKI-1447"]
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[{"$nulls":3},"CZC24832","Epoxomicin (BU-4061T)","MK-8745","GSK923295","Taselisib (GDC 0032)","PYR-41","BMS-833923","ML347","Mdivi-1","BIO"]
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[{"$nulls":3},"Stattic","PD168393","Tepotinib (EMD 1214063)","Zotarolimus (ABT-578)","AZD1208","PR-619","TCID","NSC 319726","UNC1999","DBeQ"]
[]
[]
[]
[null,"Plate layout: L6200-17"]
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[{"$nulls":3},"Idasanutlin (RG-7388)","RepSox (E-616452)","G007-LK","MM-102","JIB-04","ML324","SF1670","ID-8","Bay 11-7085","4E1RCat"]
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[{"$nulls":3},"Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","RGFP966","Ro3280","SRPIN340","NMS-E973","Osimertinib (AZD9291)","Q-VD-Oph","ERK5-IN-1","EPZ004777","UNC669"]
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[{"$nulls":3},"Bisindolylmaleimide I (GF109203X)","UNC0642","AZD2858","FRAX597","NMS-873","PJ34 HCl","Z-DEVD-FMK","IPI-3063","HS-173","AEBSF HCl"]
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[{"$nulls":3},"Thiamet G","GSK2801","Onvansertib (NMS-P937)","4μ8C","PFK15","IWP-L6","PFI-3","CW069","K02288","E-64"]
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[{"$nulls":3},"Losmapimod (GW856553X)","IOX1","FLLL32","SGI-1027","RG2833 (RGFP109)","MS436","HTH-01-015","CH5138303","BRD7552","Pepstatin A"]
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[{"$nulls":3},"OAC1","OG-L002","Beta-Lapachone","HPOB","PFI-2 HCl","GSK2606414","Itanapraced (CHF 5074)","URMC-099","Atglistatin","MG-101 (ALLN)"]
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[{"$nulls":3},"Alvelestat (AZD9668)","NVP-TNKS656","Vidofludimus","Edoxaban tosylate Monohydrate","Apabetalone (RVX-208)","BAY 87-2243","TMP269","JSH-23","4EGI-1","Z-FA-FMK"]
[]
[]
[]
[null,"Plate layout: L6200-18"]
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[{"$nulls":3},"Calpeptin","SB-3CT","APX-3330","PI-1840","WIKI4","FR 180204","AT13148","Ledipasvir (GS5885)","Filgotinib (GLPG0634)","PI-3065"]
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[{"$nulls":3},"Sorafenib (BAY 43-9006)","TAPI-1","CORM-3","Triapine","Uprosertib (GSK2141795)","XMD8-92","IM-12","GSK J1","EI1","SD-208"]
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[{"$nulls":3},"Anisomycin","ME0328","XEN445","MG149","(S)-crizotinib","Vactosertib (TEW-7197)","UNC0379","Reversine","CPI-169","LDN-214117"]
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[{"$nulls":3},"CA-074 methyl ester (CA-074 Me)","WS3","VER-50589","FH535","LY2857785","Pritelivir (BAY 57-1293)","GSK-LSD1 2HCl","Splitomicin","MI-2 (Menin-MLL Inhibitor)","TH588"]
[]
[]
[]
[null,"Plate layout: L6200-19"]
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[{"$nulls":3},"Cerdulatinib (PRT062070) hydrochloride","Peficitinib (ASP015K)","Omaveloxolone (RTA-408)","Salirasib","LY2584702 Tosylate","BRD73954","KNK437","SU6656","SRT2104 (GSK2245840)","AT7519 HCl"]
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[{"$nulls":3},"SU9516","Telaglenastat (CB-839)","L-685,458","ML141","VX-11e","NU1025","VER155008","Emricasan (IDN-6556)","Purvalanol A","Afatinib (BIBW2992) Dimaleate"]
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[{"$nulls":3},"Remodelin hydrobromide","CPI-360","PF-4989216","GSK269962A HCl","BMH-21","AZD3839","Pluripotin (SC1)","Akti-1/2","Iadademstat (ORY-1001) 2HCl","MHY1485"]
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[{"$nulls":3},"D 4476","Kartogenin","Sacubitril/valsartan (LCZ696)","BG45","SBE 13 HCl","LFM-A13","BPTES","Smoothened Agonist (SAG) HCl","GSK2879552 2HCl","Itacitinib (INCB39110)"]
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[{"$nulls":3},"Pilaralisib (XL147)","Obeticholic Acid","YK-4-279","PS-1145","Monomethyl auristatin E (MMAE)","SB239063","6-Thio-dG","Sunitinib (SU11248)","GNE-317","AMG319"]
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[{"$nulls":3},"Voxtalisib (XL765)","Ruboxistaurin (LY333531) HCl","SP2509","Ceralasertib (AZD6738)","Bikinin","SCR7","AZ6102","Combretastatin A4","Pexmetinib (ARRY-614)","MI-136"]
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[{"$nulls":3},"OTS964","GSK2578215A","OF-1","AZD8186","PRIMA-1","Ro-3306","BP-1-102","Erlotinib (OSI-774)","GSK503","MI-463"]
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[{"$nulls":3},"MI-773 (SAR405838)","Picropodophyllin (PPP)","PIK-III","LY2409881","Eprenetapopt (APR-246)","EPZ015666 (GSK3235025)","STF-083010","Docetaxel Trihydrate","FRAX486","EPZ020411 2HCl"]
[]
[]
[]
[null,"Plate layout: L6200-20"]
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[{"$nulls":3},"Licochalcone A","Ulixertinib (BVD-523)","NVP-CGM097","Sodium Tauroursodeoxycholate (TUDC)","SH5-07 (SH-5-07)","O4I2","EPI-001","FG-2216","Ricolinostat (ACY-1215)","Capivasertib (AZD5363)"]
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[{"$nulls":3},"SGC707","Dibutyryl-cAMP (Bucladesine)","SBI-0206965","PFI-4","VR23","PX-12","SIS3 HCl","A-196","PQ 401","GSK3787"]
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[{"$nulls":3},"OICR-9429","SC79","Onatasertib (CC 223)","Isoxazole 9 (ISX-9)","Y-39983 HCl","MRT67307 HCl","TIC10 (ONC201)","LDC4297 (LDC044297)","ZM 39923 HCl","WY-14643 (Pirinixic Acid)"]
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[{"$nulls":3},"I-BRD9","Oltipraz","Spautin-1","BIO-acetoxime","Belumosudil (KD025)","MRT68921 HCl","PLX7904","Ripasudil (K-115) hydrochloride dihydrate","SMI-4a","Butein"]
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[{"$nulls":3},"BI-847325","Oleuropein","Xanthohumol","Kenpaullone","Nemiralisib","Ochromycinone (STA-21)","AZD8835","Entrectinib (RXDX-101)","BIX 01294","Necrostatin-1"]
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[{"$nulls":3},"SirReal2","LJH685","CC-115","Bromodeoxyuridine (BrdU)","GSK2292767","ETC-1002","Favipiravir (T-705)","SKF96365","VE-821","UPF 1069"]
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[{"$nulls":3},"AZD3264","LJI308","Avadomide (CC-122)","DEL-22379","O4I1","CP21R7 (CP21)","Napabucasin (BBI608)","Tenovin-1","Nirogacestat (PF-03084014)","Zelavespib (PU-H71)"]
[]
[]
[]
[null,"Plate layout: L6200-21"]
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[{"$nulls":3},"Scriptaid","Nutlin-3b","Mirin","BMS-582949","RSL3","BH3I-1","Oclacitinib maleate","IC261","GSK6853","NQDI-1"]
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[{"$nulls":3},"BMS-345541","Chaetocin","K03861","Pamapimod","GDC-0326","Wnt agonist 1","MK-4101","SMER28","SRT2183","Atractylenolide I"]
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[{"$nulls":3},"Dynasore","UNC0638","CB-5083","Deguelin","ON123300","BI-7273","Hydroxyfasudil (HA-1100) HCl","Etomoxir sodium salt","FCCP","dBET1"]
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[{"$nulls":3},"Tubastatin A","PluriSIn #1 (NSC 14613)","NSC59984","Halofuginone","Cucurbitacin B","SBI-0640756","BAY 1217389","IQ-1","IMR-1","HA15"]
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[{"$nulls":3},"ETP-46464","RI-1","GSK591","MS049","Daprodustat (GSK1278863)","CPI-637","NT157","HPI-4 (Ciliobrevin A)","MKC-3946","TRC051384"]
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[{"$nulls":3},"Pacritinib (SB1518)","Bardoxolone Methyl","MS023","PD0166285","Verubecestat (MK-8931) Trifluoroacetate","Lanabecestat (AZD3293)","RS-1","CCT245737","CPI-455 HCl","3BDO"]
[]
[]
[]
[null,"Plate layout: L6200-22"]
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[{"$nulls":3},"SKL2001","XMU-MP-1","UNC3866","ML-7 HCl","PNU-74654","8-OH-DPAT (8-Hydroxy-DPAT)","CBL0137 HCl","A-317491","Seletalisib (UCB-5857)","Serabelisib (TAK-117)"]
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[{"$nulls":3},"Samotolisib (LY3023414)","PF-06409577","NMS-P118","Mivebresib (ABBV-075)","Troglitazone (CS-045)","ZINC00881524 (ROCK inhibitor)","GSK2982772","Senexin A","HJC0152","ACSS2 inhibitor"]
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[{"$nulls":3},"ITSA-1 (ITSA1)","1400W 2HCl","Apoptozole","KRIBB11","NS-398 (NS398)","VPS34 inhibitor 1 (Compound 19)","GSK180736A (GSK180736)","GDC-0575 (ARRY-575)","Verubecestat (MK-8931)","SF2523"]
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[{"$nulls":3},"Saccharin 1-methylimidazole (SMI)","Miransertib (ARQ 092) HCl","Lys05","MX69","B02","Salermide","PD-166866 (PD166866)","Temuterkib (LY3214996)","Omarigliptin (MK-3102)","Pamiparib (BGB-290)"]
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[{"$nulls":3},"KYA1797K","SGC2085","BGP-15 2HCl","RRx-001","T-3775440 HCl","Citarinostat (ACY-241)","PF-06726304","Ritlecitinib (PF-06651600)","Tucidinostat (Chidamide)","Autophinib"]
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[{"$nulls":3},"CeMMEC1 HCl","PT2385","Rbin-1","KG-501 (2-naphthol-AS-E-phosphate)","Monastrol","LF3","WT161","TAS-102","Amcasertib (BBI503)","LYN-1604"]
[]
[]
[]
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[{"$nulls":3},"NGP 555","GSK'963","CA3 (CIL56)","Selective PI3Kδ Inhibitor 1 (compound 7n)","Atuveciclib (BAY-1143572)","INCB054329","Lanifibranor (IVA-337)","CC-90003","compound 3i (666-15)","Gambogenic acid"]
[null,"b","Empty","S8605","S8644","S8662","S8696","S8728","S8760","S8771","S8803","S8872","S9032","Empty"]
[{"$nulls":3},"C188-9","GNF-6231","PTC-028","2-D08","PK11000","Iberdomide (CC220)","IDF-11774","MK-3903","GSK8612","Sanguinarine"]
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[{"$nulls":3},"JQ-EZ-05 (JQEZ5)","IWP-O1","Pemrametostat (GSK3326595)","SNS-314 Mesylate","Bimiralisib (PQR309)","Adavivint (SM04690)","LY 3200882","Brepocitinib (PF-06700841)","L-Fucose","Incensole acetate"]
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[{"$nulls":3},"Sodium dichloroacetate (DCA)","iCRT3","Elimusertib (BAY-1895344) hydrochloride","MK-8353 (SCH900353)","PLX51107","dBET6","TH34","PFK158","Luteoloside","Isochlorogenic acid C"]
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[{"$nulls":3},"OSS_128167","ACY-738","Tenalisib (RP6530)","iCRT14","SKLB-23bb","ZL0420","WM-1119","DC661","Dihydrotanshinone I","(20R)Ginsenoside Rh2"]
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[{"$nulls":3},"3-TYP","ex229 (compound 991)","AZD1390","UM-164","PHY34","IITZ-01","UPGL00004","SPHINX31","(20R)Ginsenoside Rg3","Calycosin"]
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[{"$nulls":3},"Chk2 Inhibitor II (BML-277)","kira6","Selective JAK3 inhibitor 1","INCB057643","MBQ-167","Abrocitinib (PF-04965842)","SSE15206","LIT-927","20S-Ginsenoside Rg3","Albiflorin"]
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[{"$nulls":3},"Diphenyleneiodonium chloride (DPI)","GI254023X","AS1517499","ABBV-744","leniolisib (CDZ 173)","Tinostamustine(EDO-S101)","ML385","V-9302","Hastatoside","Maslinic acid"]
[]
[]
[]
[null,"Plate layout: L6200-24"]
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[{"$nulls":3},"Corosolic acid","Hydroxy safflor yellow A","Calycosin-7-O-beta-D-glucoside","Eleutheroside E","Apigetrin","Epiberberine","Sinapine thiocyanate","Santalol","Isosilybin","Isochlorogenic acid A"]
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[{"$nulls":3},"Wedelolactone","Trilobatin","Magnoflorine","Glycitein","Schizandrol B","Aurantio-obtusin","Forsythoside B","Schisandrin C","Lithospermic acid","Aloesin"]
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[{"$nulls":3},"6-Shogaol","Isoxanthohumol","10-Gingerol","Timosaponin A3","20(S)-Ginsenoside Rh1","Ziyu-glycoside I","Oroxin A","Schisanhenol","3-n-Butylphathlide","Dictamnine"]
[null,"d","Empty","S9046","S9071","S9094","S9112","S9136","S9163","S9190","S9234","S9265","S9293","Empty"]
[{"$nulls":3},"Berberine","Nootkatone","Pogostone","Kaempferitrin","Neochlorogenic acid","Rhapontigenin","Oroxin B","Schaftoside","7-Epitaxol","Isoliquiritin"]
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[{"$nulls":3},"Leonurine Hydrochloride","Plantamajoside","Senegenin","Polyphyllin I","Berbamine","Columbin","Aristolochic acid A","α-Cyperone","Koumine","Corylin"]
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[{"$nulls":3},"(+)-Gallocatechin","Anhydroicaritin","Dehydrodiisoeugenol","Wogonoside","Anwuligan","Engeletin","Oroxylin A","Isofraxidin","Isochlorogenic acid B","Ginsenoside F1"]
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[{"$nulls":3},"Salvianolic acid A","Rhoifolin","Fraxinellone","Scutellarein","Peiminine","Phellodendrine","Eriocitrin","Polygalaxanthone III","Isoguanosine","Cyanidin-3-O-glucoside chloride"]
[null,"h","Empty","S9057","S9085","S9105","S9121","S9149","S9174","S9221","S9243","S9280","S9315","Empty"]
[{"$nulls":3},"Sinigrin","Corynoline","Ginsenoside CK","Irigenin","Benzoylpaeoniflorin","Xanthotoxol","Ferulaldehyde","Protosappanin B","Demethoxycurcumin","Praeruptorin A"]
[]
[]
[]
[null,"Plate layout: L6200-25"]
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[{"$nulls":3},"(20R)-Ginsenoside Rh1","4-Hydroxyquinazoline","Ecliptasaponin A","Liensinine diperchlorate","Bergaptol","Rotundic acid","ML346","INH14","SW-044248","Homoharringtonine (CGX-635)"]
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[{"$nulls":3},"Cryptochlorogenic acid","2',5'-Dihydroxyacetophenone","Sauchinone","Brazilin","Isorhamnetin 3-O-neohesperoside","Farrerol","AG-126","MKT-077","ML364","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)"]
[null,"c","Empty","S9322","S9379","S9407","S9431","S9473","S9567","S6616","S6721","S6751","S9050","Empty"]
[{"$nulls":3},"Neodiosmin","Dihydrocoumarin","Angoroside C","Dehydrocorydalin","Nuzhenide","Indinavir Sulfate","ETC-159","JG98","Brevianamide F","Boldine"]
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[{"$nulls":3},"Orcinol","Sophocarpine Monohydrate","Liensinine","Ginkgolic Acid","Raspberry Ketone","Aurora Kinase Inhibitor III","APY29","Edonerpic maleate","Pimitespib (TAS-116)","Irisflorentin"]
[null,"e","Empty","S9338","S9397","S9413","S9434","S9487","S2933","S6626","S6734","S8828","S9102","Empty"]
[{"$nulls":3},"Octyl gallate","Alliin","Yangonin","8-Gingerol","Praeruptorin C","AM580","Brequinar (DUP785)","PF-670462","Gboxin","Magnolin"]
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[{"$nulls":3},"3,4-Dimethoxycinnamic acid","1,2,3,4,6-O-Pentagalloylglucose","Homoplantaginin","Echinatin","Madecassic acid","NG 52","Belotecan (CKD-602) hydrochloride","MN 64","Borussertib","Morin"]
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[{"$nulls":3},"Ethyl 4-Methoxycinnamate","Rhynchophylline","Parishin B","Naringenin chalcone","Fraxetin","Adelmidrol","Azaindole 1 (TC-S 7001)","Inauhzin","AZD7648","Isorhamnetin"]
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[{"$nulls":3},"2,4'-Dihydroxybenzophenone","3,6'-Disinapoyl sucrose","Narcissoside","Sibiricose A5","(−)-Norepinephrine","DMNQ","PF-06282999","JW55","Orludodstat (BAY 2402234)","Eriodictyol"]
[]
[]
[]
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[{"$nulls":3},"Harpagoside","BML-210 (CAY10433)","NKL 22","UBCS039","Toloxatone (MD69276)","Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)","Brassinazole","TH-257","ASP4132","Dimethylenastron"]
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[{"$nulls":3},"Vitexin","Indirubin-3'-monoxime","Bardoxolone","Ginsenoside F2","Desciclovir","FK-3311","STAT5-IN-1","R-10015","BRD3308","HSF1A"]
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[{"$nulls":3},"Homoorientin","SR-4370","EN6","ligustroflavone","ML216","NSC 632839","ERK5-IN-2","THZ2","HQNO","XCT790"]
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[{"$nulls":3},"Fargesin","PF 4800567","VAS2870","Chikusetsusaponin IVa","Purvalanol B","PD 169316","Ellipticine hydrochloride","PQR620","Verdiperstat","TBK1/IKKε-IN-2"]
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[{"$nulls":3},"Casticin","Indoprofen","CCG-222740","(20S)Ginsenoside Rg2","ML 210","ATB 346","BTB-1","RK-287107","GLX351322","Indibulin"]
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[{"$nulls":3},"Triptonide","Eprobemide","L-779450","Punicalagin","Licofelone (ML3000)","Mavacoxib","CX546","SR-4835","BMS-5","KY1220"]
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[{"$nulls":3},"momordin-Ic","Parbendazole","BAY1125976","Didymin","Rubitecan","SC-560","GS-441524","AS2863619","ML241 hydrochloride","CBL0137"]
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[{"$nulls":3},"BI-1347","Nicotinamide Riboside Chloride","USP25/28 inhibitor AZ1","L 189","Triglycidyl Isocyanurate (Teroxirone)","TFAP","TMB dihydrochloride","TED-347","IMR-1A","Silmitasertib (CX-4945) sodium salt"]
[]
[]
[]
[null,"Plate layout: L6200-27"]
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[{"$nulls":3},"Isuzinaxib (APX-115 free base)","Raspberry ketone glucoside","Pectolinarigenin","Marmesin","Miransertib (ARQ-092)","HI-TOPK-032","RBN012759","MDL-800","Recilisib","MST-312"]
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[{"$nulls":3},"Apilimod (STA-5326) mesylate","L-Quebrachitol","Tectochrysin","Myristicin","GRL0617","1-Aminobenzotriazole","Elraglusib","MK-0159","Sulfosuccinimidyl oleate sodium","S-Nitrosoglutathione"]
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[{"$nulls":3},"STAT3-IN-1","Cinobufagin","Myrislignan","Hispidulin","NE 52-QQ57","Monomethyl Fumarate","IM156","Usp22i-S02","EN450","Zandelisib"]
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[{"$nulls":3},"BL-918","5,7-Dimethoxyflavone","Scopolin","Caulophylline (N-Methylcytisine)","RA-190","CDKI-73","Apcin","NF-κΒ activator 1","UCL-TRO-1938","2,4-dihydroxybenzaldehyde"]
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[{"$nulls":3},"Tenovin-3","Sinapine","Genipin 1-O-beta-D-gentiobioside","Cynarin","Triazavirin","BAY 1251152","ABTL-0812","YLF-466D","ACT001(DMAMCL)","Pasireotide"]
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[{"$nulls":3},"Perillaldehyde","Resibufogenin","Hypericin","β,β-dimethyl-acryl-alkannin","EOAI3402143","GCN2iB","VX-803 (M4344)","Sodium Pyruvate","B022","Sildenafil"]
[null,"g","Empty","S3213","S3241","S3274","S3305","S6878","S8974","S9649","E2914","E1716","Empty","Empty"]
[{"$nulls":3},"Veratryl alcohol","Loureirin A","Glucosyl-vitexin","Medicagenic acid","GSK2643943A","GSK2795039","Acelarin (NUC-1031)","5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside","SR9011"]
[null,"h","Empty","S3220","S3242","S3280","S6760","S6880","S8978","S9687","E2943","E1735","Empty","Empty"]
[{"$nulls":3},"Trigonelline","Loureirin B","Linderene","LM22B-10","SRT-1460","Mitoquinone (MitoQ10) mesylate","H2DCFDA","Pifithrin-β","PK11007"]
[]
[]
[]
[null,"Plate layout: L6200-28"]
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[{"$nulls":3},"Perifosine (KRX-0401)","Ibuprofen Lysine","Fudosteine","L-Arginine HCl (L-Arg)","Dexamethasone Sodium Phosphate","Glutathione","Sodium L-ascorbyl-2-phosphate","L-arginine","LDN-193189 2HCl","DL-Methionine"]
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[{"$nulls":3},"Palbociclib (PD-0332991) HCl","Palbociclib (PD0332991) Isethionate","Chondroitin sulfate","β-Glycerophosphate sodium salt hydrate","Colistin Sulfate","Cefradine","L-carnosine","5-Methylcytosine","Rilmenidine Phosphate","Foscarnet Sodium"]
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[{"$nulls":3},"Pemetrexed (LY-231514) disodium","Cytarabine (U-19920A)","Aloperine","(S)-Methylisothiourea sulfate","Chloroquine diphosphate","Sodium ferulate","5'-Cytidylic acid","3-Chloro-L-tyrosine","Pemetrexed Disodium Hydrate","Estramustine phosphate sodium"]
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[{"$nulls":3},"Gemcitabine (LY-188011) HCl","D-glutamine","Donepezil HCl","L-Leucine","Nefopam HCl","Danshensu","UTP Trisodium Salt","Malachite green","Disodium (R)-2-Hydroxyglutarate","Cytidine 5′-triphosphate (disodium salt)"]
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[{"$nulls":3},"Dorzolamide HCl","ATP disodium","Salbutamol Sulfate","Phytic acid","Proflavine Hemisulfate","S-Methyl-L-cysteine","Loxoprofen Sodium","Chlorophyllin (sodium copper salt)","Ac-DEVD-CHO","L-(+)-Ergothioneine"]
[null,"f","Empty","S1384","S1995","S2877","S3852","S4245","S4791","S5545","S7204","S8199","E1689","Empty"]
[{"$nulls":3},"Mizoribine","Procarbazine HCl","L-NAME HCl","L-Theanine","Sodium ascorbate","S-allyl-L-cysteine","DL-Serine","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","Ruxotemitide (LTX 315)","NADPH tetrasodium salt"]
[null,"g","Empty","S1494","S1999","S3013","S3973","S4360","S4993","S5584","S7306","S8651","S2542","Empty"]
[{"$nulls":3},"Ralimetinib (LY2228820) dimesylate","Sodium butyrate","Plerixafor (AMD3100) 8HCl","L-SelenoMethionine","Tolmetin Sodium","Timonacic","Citronellol","Dorsomorphin (Compound C) 2HCl","bpV (HOpic)","Phenformin (NSC-756501) HCl"]
[null,"h","Empty","S1516","S2008","S3056","S3989","S4430","S5097","S5633","S7419","S9062","Empty","Empty"]
[{"$nulls":3},"Cidofovir","Taurine","Miltefosine","L-​Histidine","Hydroxychloroquine Sulfate (NSC 4375)","Methotrexate disodium","L-methionine","Blasticidin S HCl","4-Hydroxyisoleucine"]
[]
[]
[]
[null,"Plate layout: L6200-29"]
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[{"$nulls":3},"Erlotinib (OSI-774) HCl","GSK1059615","Vinpocetine","LY2109761","Ambroxol HCl","6-Biopterin","XL388","Dorsomorphin (Compound C)","SJB2-043"]
[null,"b","Empty","S1046","S1424","S2157","S2735","S3614","S5611","S7061","S7842","S3299","Empty","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)","Prazosin HCl","Taladegib (LY2940680)","MK-8776 (SCH 900776)","Lupeol","2-cyano-Pyrimidine","GSK126","LY3009120","Demethyleneberberine"]
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[{"$nulls":3},"XL147 analogue","Marbofloxacin","Ketanserin","CCT137690","Sodium Aescinate","Xanthopterin Hydrate","IWP-2","BI-9564","Stylopine"]
[null,"d","Empty","S1205","S1509","S2251","S2805","S3891","S5712","S7128","S8138","S8274","Empty","Empty"]
[{"$nulls":3},"PIK-75 HCl","Norfloxacin","(-)-Huperzine A (HupA)","LY364947","Vincamine","Zofenopril calcium","Tazemetostat (EPZ-6438)","Molidustat (BAY 85-3934)","STO-609"]
[null,"e","Empty","S1211","S1519","S2476","S2827","S4605","S5902","S7164","S8229","Empty","Empty","Empty"]
[{"$nulls":3},"Imiquimod (R-837)","CCT129202","Itraconazole (R 51211)","Torin 1","Folic acid","1,2,3,4,5,6-Hexabromocyclohexane","GSK343","Brigatinib (AP26113)"]
[null,"f","Empty","S1288","S1724","S2628","S2870","S4930","S6606","S7400","S8527","Empty","Empty","Empty"]
[{"$nulls":3},"Camptothecin (NSC-100880)","Paliperidone","Gedatolisib (PKI-587)","TG100713","Cetilistat","CDD3505","ISRIB (trans-isomer)","ROC-325"]
[null,"g","Empty","S1327","S1837","S2638","S2893","S5116","S6642","S7518","S9246","Empty","Empty","Empty"]
[{"$nulls":3},"Ellagic acid","Flubendazole","NU7441 (KU-57788)","NU7026","Bilibubin","Branaplam (LMI070)","Voreloxin (SNS-595) hydrochloride","Tiliroside"]
[null,"h","Empty","S1353","S2047","S2684","S3042","S5516","S7004","S7698","S8875","Empty","Empty","Empty"]
[{"$nulls":3},"Ketoconazole (R 41400)","Lornoxicam","Pidnarulex (CX-5461)","Purmorphamine","Ellagic Acid hydrate","EPZ005687","LY2584702","MKC8866"]
[]
[]
[]
[null,"Plate layout: L6200-30"]
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[{"$nulls":3},"Disodium Cromoglycate"]
[null,"b","Empty","S1982","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Adenine sulfate"]
[null,"c","Empty","S8030","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Plerixafor (AMD3100)"]
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[]
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[]
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[]
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[]
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{"sheet":"L6200-Anti-Aging-2308 cpds","index":1,"n_rows":2309,"n_cols":23,"rows_kept":2309}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1002","ABT-737","a2","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Mitophagy","Apoptosis","ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.",813.43,"852808-04-9",{"v":100,"d":"100.00"},122.94,"<1","N/A","http://selleckchem.com/products/ABT-737.html","C42H45ClN6O5S2","free base","N/A","CN(C)CCC(CSC1=CC=CC=C1)NC2=CC=C(C=C2[N+]([O-])=O)[S](=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=C(C=CC=C5)C6=CC=C(Cl)C=C6",8.198,3,2,16]
["S1003","Linifanib (ABT-869)","b2","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,CSF-1R,FLT3,PDGFR,VEGFR","Protein Tyrosine Kinase","Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.",375.41,"796967-16-3",{"v":75,"d":"75.00"},199.78,"<1","N/A","http://selleckchem.com/products/ABT-869.html","C21H18FN5O","free base","AL39324,RG3635","CC1=CC(=C(F)C=C1)NC(=O)NC2=CC=C(C=C2)C3=C4C(=N[NH]C4=CC=C3)N",4.169,2,4,3]
["S1004","Veliparib (ABT-888)","c2","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,PARP","DNA Damage/DNA Repair","Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.",244.29,"912444-00-9",{"v":17,"d":"17.00"},69.59,"<1","N/A","http://selleckchem.com/products/ABT-888.html","C13H16N4O","free base","NSC 737664","CC1(CCCN1)C2=NC3=C(C=CC=C3[NH]2)C(N)=O",0.986,2,3,2]
["S1006","Saracatinib (AZD0530)","d2","L6200-01","in 10mM DMSO","Autophagy,EGFR,Src","Angiogenesis","Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3.",542.03,"379231-04-6",{"v":35,"d":"35.00"},64.57,"<1","N/A","http://selleckchem.com/products/AZD0530.html","C27H32ClN5O5","free base","N/A","CN1CCN(CCOC2=CC(=C3C(=NC=NC3=C2)NC4=C(Cl)C=CC5=C4OCO5)OC6CCOCC6)CC1",3.814,7,1,8]
["S1007","Roxadustat (FG-4592)","e2","L6200-01","in 10mM DMSO","Ferroptosis,HIF","Angiogenesis","Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3.",352.34,"808118-40-3",{"v":70,"d":"70.00"},198.67,"<1","N/A","http://selleckchem.com/products/fg-4592.html","C19H16N2O5","free base","ASP1517","CC1=NC(=C(O)C2=C1C=C(OC3=CC=CC=C3)C=C2)C(=O)NCC(O)=O",2.306,4,2,5]
["S1012","BMS-536924","f2","L6200-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","BMS-536924 (CS-0117) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.",479.96,"468740-43-4",{"v":96,"d":"96.00"},200.02,"<1","N/A","http://selleckchem.com/products/BMS-536924.html","C25H26ClN5O3","free base","CS-0117","CC1=C2N=C([NH]C2=CC(=C1)N3CCOCC3)C4=C(NCC(O)C5=CC=CC(=C5)Cl)C=CNC4=O",2.385,3,4,6]
["S1013","Bortezomib (PS-341)","g2","L6200-01","in 10mM DMSO","Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome","Proteases","Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.",384.24,"179324-69-7",{"v":76,"d":"76.00"},197.79,"<1","N/A","http://selleckchem.com/products/Bortezomib.html","C19H25BN4O4","Free Base","Velcade, LDP-341, MLM341, NSC 681239,PS-341","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O",2.183,4,2,9]
["S1014","Bosutinib (SKI-606)","h2","L6200-01","in 10mM DMSO","Autophagy,Bcr-Abl,ERK,S6 Kinase,Src,STAT","Angiogenesis","Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.",530.45,"380843-75-4",{"v":100,"d":"100.00"},188.52,"<1","N/A","http://selleckchem.com/products/Bosutinib.html","C26H29Cl2N5O3","free base","SKI-606","COC1=C(Cl)C=C(Cl)C(=C1)NC2=C(C=NC3=CC(=C(OC)C=C23)OCCCN4CCN(C)CC4)C#N",4.883,4,1,9]
["S1017","Cediranib (AZD2171)","a3","L6200-01","in 10mM DMSO","Autophagy,c-Kit,PDGFR,VEGFR","Protein Tyrosine Kinase","Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.",450.51,"288383-20-0",{"v":90,"d":"90.00"},199.77,"<1","N/A","http://selleckchem.com/products/Cediranib.html","C25H27FN4O3","free base","NSC-732208","COC1=C(OCCCN2CCCC2)C=C3N=CN=C(OC4=C(F)C5=C([NH]C(=C5)C)C=C4)C3=C1",4.761,5,1,8]
["S1021","Dasatinib (BMS-354825)","b3","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,c-Kit,Src","Angiogenesis","Dasatinib (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.",488.01,"302962-49-8",{"v":98,"d":"98.00"},200.82,"<1","N/A","http://selleckchem.com/products/Dasatinib.html","C22H26ClN7O2S","free base","BMS-354825","CC1=NC(=CC(=N1)N2CCN(CCO)CC2)NC3=NC=C(S3)C(=O)NC4=C(Cl)C=CC=C4C",3.439,4,3,7]
["S1022","Ridaforolimus (Deforolimus, MK-8669)","c3","L6200-01","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.",990.21,"572924-54-0",{"v":198,"d":"198.00"},199.96,"<1","N/A","http://selleckchem.com/products/Deforolimus.html","C53H84NO14P","free base","AP23573","COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.303,12,1,8]
["S1025","Gefitinib (ZD1839)","d3","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,EGFR","Protein Tyrosine Kinase","Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.",{"v":446.9,"d":"446.90"},"184475-35-2",{"v":89,"d":"89.00"},199.15,"<1","N/A","http://selleckchem.com/products/Gefitinib.html","C22H24ClFN4O3","free base","Iressa,ZD1839","COC1=C(OCCCN2CCOCC2)C=C3C(=NC=NC3=C1)NC4=CC=C(F)C(=C4)Cl",4.203,5,1,8]
["S1026","Imatinib (STI571) Mesylate","e3","L6200-01","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.",589.71,"220127-57-1",{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},{"v":118,"d":"118.00"},{"v":200.1,"d":"200.10"},"http://selleckchem.com/products/Imatinib-Mesylate.html","C29H31N7O.CH4SO3","Mesylate","Gleevec, Glivec, CGP-57148B,STI571","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5.C[S](O)(=O)=O",3.806,4,2,7]
["S1028","Lapatinib (GW-572016) Ditosylate","f3","L6200-01","in 10mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.",925.46,"388082-77-7",{"v":100,"d":"100.00"},108.05,"<1","N/A","http://selleckchem.com/products/Lapatinib-Ditosylate.html","C29H26ClFN4O4S.2C7H8O3S","Ditosylat","GW-572016","CC1=CC=C(C=C1)[S](O)(=O)=O.CC2=CC=C(C=C2)[S](O)(=O)=O.C[S](=O)(=O)CCNCC3=CC=C(O3)C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(=C7)F)C(=C6)Cl)C5=C4",9.339,6,2,13]
["S1030","Panobinostat (LBH589)","g3","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC,HIV Protease","Epigenetics","Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.",349.43,"404950-80-7",{"v":69,"d":"69.00"},197.46,"<1","N/A","http://selleckchem.com/products/LBH-589.html","C21H23N3O2","Free Base","NVP-LBH589","CC1=C(CCNCC2=CC=C(\\C=C\\C(=O)NO)C=C2)C3=C([NH]1)C=CC=C3",3.194,1,3,7]
["S1033","Nilotinib (AMN-107)","h3","L6200-01","in 10mM DMSO","AMPK,Autophagy,Bcr-Abl","Angiogenesis","Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.",529.52,"641571-10-0",{"v":27,"d":"27.00"},50.99,"<1","N/A","http://selleckchem.com/products/Nilotinib.html","C28H22F3N7O","free base","AMN-107","CC1=C[N](C=N1)C2=CC(=CC(=C2)C(F)(F)F)NC(=O)C3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CC=C5",5.084,5,2,7]
["S1035","Pazopanib HCl (GW786034 HCl)","a4","L6200-01","in 10mM DMSO","Autophagy,c-Kit,CSF-1R,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.",473.98,"635702-64-6",{"v":17,"d":"17.00"},35.87,"<1","N/A","http://selleckchem.com/products/Pazopanib-Hydrochloride.html","C21H23N7O2S.HCl","Hydrochloride","GW786034 HCl","Cl.C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",4.123,5,2,5]
["S1036","Mirdametinib (PD0325901)","b4","L6200-01","in 10mM DMSO","MEK","MAPK","Mirdametinib (PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.",482.19,"391210-10-9",{"v":96,"d":"96.00"},199.09,"<1","N/A","http://selleckchem.com/products/PD-0325901.html","C16H14F3IN2O4","free base","N/A","OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(=C(F)C=C1)F",2.578,2,4,7]
["S1038","PI-103","c4","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.",348.36,"371935-74-9",{"v":24,"d":"24.00"},68.89,"<1","N/A","http://selleckchem.com/products/PI-103.html","C19H16N4O3","free base","N/A","OC1=CC(=CC=C1)C2=NC3=C(OC4=C3C=CC=N4)C(=N2)N5CCOCC5",2.798,5,1,2]
["S1039","Rapamycin (AY-22989)","d4","L6200-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1","N/A","http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1040","Sorafenib (BAY 43-9006) tosylate","e4","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate)  is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",637.03,"475207-59-1",{"v":127,"d":"127.00"},199.36,0.01,0.02,"http://selleckchem.com/products/Sorafenib-Tosylate.html","C21H16ClF3N4O3.C7H8O3S","Tosylate","BAY 43-9006 tosylate,NSC-724772 tosylate","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O",5.824,4,3,7]
["S1041","STF-62247","f4","L6200-01","in 10mM DMSO","Autophagy","Autophagy","STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).",267.35,"315702-99-9",{"v":53,"d":"53.00"},198.24,"<1","N/A","http://selleckchem.com/products/STF-62247.html","C15H13N3S","free base","N/A","CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3",3.659,2,1,3]
["S1042","Sunitinib (SU11248) malate","g4","L6200-01","in 10mM DMSO","Apoptosis related,c-Kit,IRE1,Mitophagy,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.",532.56,"341031-54-7",{"v":15,"d":"15.00"},28.17,"<1","N/A","http://selleckchem.com/products/Sunitinib-Malate-(Sutent).html","C22H27FN4O2.C4H6O5","Malate","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=CC=C(F)C=C23.OC(CC(O)=O)C(O)=O",-1.049,4,4,10]
["S1044","Temsirolimus (CCI-779)","h4","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis.",1030.29,"162635-04-3",{"v":67,"d":"67.00"},65.03,"<1","N/A","http://selleckchem.com/products/Temsirolimus.html","C56H87NO16","free base","NSC 683864,CCI-779","COC1CC(CCC1OC(=O)C(C)(CO)CO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.039,12,3,11]
["S1047","Vorinostat (SAHA)","a5","L6200-01","in 10mM DMSO","Autophagy,HDAC,HPV","Epigenetics","Vorinostat (SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.",{"v":264.3,"d":"264.30"},"149647-78-9",{"v":52,"d":"52.00"},196.75,"<1","N/A","http://selleckchem.com/products/Vorinostat-saha.html","C14H20N2O3","free base","SAHA,MK0683, Suberoylanilide hydroxamic acid, Zolinza","ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1",2.005,2,2,8]
["S1048","Tozasertib","b5","L6200-01","in 10mM DMSO","Aurora Kinase,Autophagy,Bcr-Abl,FLT3","Cell Cycle","Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.",464.59,"639089-54-6",{"v":93,"d":"93.00"},200.18,"<1","N/A","http://selleckchem.com/products/VX-680(MK-0457).html","C23H28N8OS","free base","VX-680, MK-0457","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)SC4=CC=C(NC(=O)C5CC5)C=C4",4.445,4,3,7]
["S1049","Y-27632 2HCl","c5","L6200-01","in 10mM DMSO","Autophagy,ROCK","Cell Cycle","Y-27632 2HCl is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",320.26,"129830-38-2",{"v":64,"d":"64.00"},199.84,{"v":14,"d":"14.00"},43.71,"http://selleckchem.com/products/Y-27632.html","C14H21N3O.2HCl","Dihydrochloride","N/A","Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.871,2,2,3]
["S1052","Elesclomol (STA-4783)","d5","L6200-01","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand and inhibits FDX1-mediated Fe-S cluster biosynthesis.",{"v":400.5,"d":"400.50"},"488832-69-5",{"v":80,"d":"80.00"},199.75,"<1","N/A","http://selleckchem.com/products/Elesclomol.html","C19H20N4O2S2","free base","N/A","CN(NC(=O)CC(=O)NN(C)C(=S)C1=CC=CC=C1)C(=S)C2=CC=CC=C2",2.885,2,2,8]
["S1053","Entinostat (MS-275)","e5","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.",376.41,"209783-80-2",{"v":75,"d":"75.00"},199.25,"<1","N/A","http://selleckchem.com/products/MS-275.html","C21H20N4O3","free base","SNDX-275","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC(=O)OCC3=CN=CC=C3)C=C2",2.071,4,3,7]
["S1055","Enzastaurin (LY317615)","f5","L6200-01","in 10mM DMSO","PKC","TGF-beta/Smad","Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM in cell-free assays, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.",515.61,"170364-57-5",{"v":30,"d":"30.00"},58.18,"<1","N/A","http://selleckchem.com/products/Enzastaurin.html","C32H29N5O2","free base","N/A","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](C5CCN(CC5)CC6=NC=CC=C6)C7=CC=CC=C47",{"v":4.32,"d":"4.320"},3,1,5]
["S1057","Obatoclax Mesylate (GX15-070)","g5","L6200-01","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.",413.49,"803712-79-0",{"v":83,"d":"83.00"},200.73,"<1","N/A","http://selleckchem.com/products/Obatoclax-Mesylate.html","C20H19N3O.CH4O3S","Mesylate","N/A","COC\\1=CC(=NC1=C\\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O",3.757,2,2,3]
["S1060","Olaparib (AZD2281)","h5","L6200-01","in 10mM DMSO","Autophagy,Mitophagy,PARP","DNA Damage/DNA Repair","Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.",434.46,"763113-22-0",{"v":86,"d":"86.00"},197.95,"N/A","N/A","http://selleckchem.com/products/AZD2281(Olaparib).html","C24H23FN4O3","free base","Ku-0059436","FC1=C(C=C(CC2=NNC(=O)C3=C2C=CC=C3)C=C1)C(=O)N4CCN(CC4)C(=O)C5CC5",2.127,4,1,4]
["S1061","Nutlin-3","a6","L6200-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1065","Pictilisib (GDC-0941)","b6","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,PI3K","PI3K/Akt/mTOR","Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.",513.64,"957054-30-7",{"v":44,"d":"44.00"},85.66,"<1","N/A","http://selleckchem.com/products/GDC-0941.html","C23H27N7O3S2","free base","RG7321","C[S](=O)(=O)N1CCN(CC1)CC2=CC3=NC(=NC(=C3S2)N4CCOCC4)C5=CC=CC6=C5C=N[NH]6",2.153,6,1,5]
["S1067","SB431542","c6","L6200-01","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.",384.39,"301836-41-9",{"v":76,"d":"76.00"},197.72,"<1","N/A","http://selleckchem.com/products/SB-431542.html","C22H16N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=NC=CC=C3)C4=CC5=C(OCO5)C=C4",3.447,5,2,4]
["S1068","Crizotinib (PF-02341066)","d6","L6200-01","in 10mM DMSO","ALK,Autophagy,c-Met,ROS1","Protein Tyrosine Kinase","Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.",450.34,"877399-52-5",{"v":9,"d":"9.00"},19.98,"<1","N/A","http://selleckchem.com/products/PF-2341066.html","C21H22Cl2FN5O","free base","PF-02341066","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S1069","Luminespib (NVP-AUY922)","e6","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),IGF-1R","Cytoskeletal Signaling","Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.",465.54,"747412-49-3",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/NVP-AUY922.html","C26H31N3O5","free base","AUY-922, VER-52296","CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C",4.069,4,3,7]
["S1072","ZSTK474","f6","L6200-01","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2.",417.41,"475110-96-4",{"v":21,"d":"21.00"},50.31,"<1","N/A","http://selleckchem.com/products/ZSTK474.html","C19H21F2N7O2","free base","N/A","FC(F)C1=NC2=C(C=CC=C2)[N]1C3=NC(=NC(=N3)N4CCOCC4)N5CCOCC5",3.366,6,0,4]
["S1075","SB216763","g6","L6200-01","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.",371.22,"280744-09-4",{"v":23,"d":"23.00"},61.96,"<1","N/A","http://selleckchem.com/products/SB-216763.html","C19H12N2O2Cl2","free base","N/A","C[N]1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CC=C(Cl)C=C4Cl",4.391,2,1,2]
["S1076","Adezmapimod (SB203580)","h6","L6200-01","in 10mM DMSO","Mitophagy,p38 MAPK","MAPK","Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.",377.43,"152121-47-6",{"v":43,"d":"43.00"},113.93,"<1","N/A","http://selleckchem.com/products/SB-203580.html","C21H16FN3OS","Free Base","RWJ 64809, PB 203580","C[S](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",3.883,3,1,4]
["S1077","SB202190 (FHPI)","a7","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,p38 MAPK","MAPK","SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.",331.34,"152121-30-7",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/SB-202190.html","C20H14N3OF","free base","N/A","OC1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",4.211,2,2,3]
["S1078","MK-2206 2HCl","b7","L6200-01","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.",480.39,"1032350-13-2",{"v":14,"d":"14.00"},29.14,"<1","N/A","http://selleckchem.com/products/MK-2206.html","C25H21N5O.2HCl","Dihydrochloride","N/A","Cl.Cl.NC1(CCC1)C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C(=O)NN=C45)C6=CC=CC=C6",4.183,3,2,3]
["S1080","SU11274","c7","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,c-Met","Protein Tyrosine Kinase","SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFRβ, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest.",568.09,"658084-23-2",{"v":92,"d":"92.00"},161.95,"<1","N/A","http://selleckchem.com/products/SU11274.html","C28H30CIN5O4S","free base","PKI-SU11274","CN1CCN(CC1)C(=O)C2=C(C)[NH]C(=C2C)/C=C/3C(=O)NC4=C3C=C(C=C4)[S](=O)(=O)N(C)C5=CC(=CC=C5)Cl",3.477,4,2,5]
["S1082","Vismodegib (GDC-0449)","d7","L6200-01","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.",{"v":421.3,"d":"421.30"},"879085-55-9",{"v":84,"d":"84.00"},199.38,"<1","N/A","http://selleckchem.com/products/GDC-0449.html","C19H14Cl2N2O3S","free base","GDC-0449","C[S](=O)(=O)C1=CC=C(C(=C1)Cl)C(=O)NC2=CC(=C(Cl)C=C2)C3=NC=CC=C3",4.265,4,1,4]
["S1084","Brivanib (BMS-540215)","e7","L6200-01","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.",370.38,"649735-46-6",{"v":74,"d":"74.00"},199.79,"<1","N/A","http://selleckchem.com/products/Brivanib.html","C19H19FN4O3","free base","N/A","CC(O)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.481,4,2,5]
["S1085","Belinostat (PXD101)","f7","L6200-01","in 10mM DMSO","Autophagy,HDAC","Epigenetics","Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy.",318.35,"866323-14-0",{"v":64,"d":"64.00"},201.04,"<1","N/A","http://selleckchem.com/products/Belinostat.html","C15H14N2O4S","free base","PXD101,NSC726630, PX-105684","ONC(=O)/C=C/C1=CC(=CC=C1)[S](=O)(=O)NC2=CC=CC=C2",{"v":1.8,"d":"1.800"},3,2,5]
["S1087","Iniparib (BSI-201)","g7","L6200-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Iniparib (BSI-201, NSC-746045, IND-71677) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.",292.03,"160003-66-7",{"v":58,"d":"58.00"},198.61,"<1","N/A","http://selleckchem.com/products/BSI-201.html","C7H5IN2O3","free base","NSC-746045, IND-71677","NC(=O)C1=CC(=C(I)C=C1)[N+]([O-])=O",1.304,1,1,2]
["S1088","NVP-ADW742","h7","L6200-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","NVP-ADW742 (GSK 552602A) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR;  little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.",453.58,"475488-23-4",{"v":10,"d":"10.00"},22.05,"<1","N/A","http://selleckchem.com/products/NVP-ADW742.html","C28H31N5O","Free Base","GSK 552602A, ADW742","NC1=NC=NC2=C1C(=C[N]2C3CC(C3)CN4CCCC4)C5=CC(=CC=C5)OCC6=CC=CC=C6",4.806,3,1,7]
["S1090","Abexinostat (PCI-24781)","a8","L6200-01","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.",397.42,"783355-60-2",{"v":80,"d":"80.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/PCI-24781.html","C21H23N3O5","free base","CRA-024781","CN(C)CC1=C(OC2=CC=CC=C12)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO",2.353,4,2,8]
["S1091","Linsitinib (OSI-906)","b8","L6200-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.",421.49,"867160-71-2",{"v":84,"d":"84.00"},199.29,"<1","N/A","http://selleckchem.com/products/OSI-906.html","C26H23N5O","free base","N/A","CC1(O)CC(C1)C2=NC(=C3[N]2C=CN=C3N)C4=CC=C5C=CC(=NC5=C4)C6=CC=CC=C6",3.757,3,1,3]
["S1092","KU-55933 (ATM Kinase Inhibitor)","c8","L6200-01","in 10mM DMSO","ATM/ATR,Autophagy,ULK","DNA Damage/DNA Repair","KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.",395.49,"587871-26-9",{"v":33,"d":"33.00"},83.44,"<1","N/A","http://selleckchem.com/products/KU-55933.html","C21H17NO3S2","free base","N/A","O=C1C=C(OC(=C1)C2=CC=CC3=C2SC4=CC=CC=C4S3)N5CCOCC5",4.393,3,0,2]
["S1093","GSK1904529A","d8","L6200-01","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","GSK1904529A (GSK 4529) is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM in cell-free assays, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc.",851.96,"1089283-49-7",{"v":124,"d":"124.00"},145.55,"<1","N/A","http://selleckchem.com/products/GSK1904529A.html","C44H47F2N9O5S","free base","GSK 4529","CCC1=CC(=C(OC)C=C1N2CCC(CC2)N3CCN(CC3)[S](C)(=O)=O)NC4=NC(=CC=N4)C5=C(N=C6C=CC=C[N]56)C7=CC(=C(OC)C=C7)C(=O)NC8=C(F)C=CC=C8F",6.571,8,2,12]
["S1095","Dacinostat (LAQ824)","e8","L6200-01","in 10mM DMSO","HDAC,p21","Epigenetics","Dacinostat (LAQ824, NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM and is known to activate the p21 promoter.",379.46,"404951-53-7",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/LAQ824(NVP-LAQ824).html","C22H25N3O3","free base","NVP-LAQ824","OCCN(CCC1=C[NH]C2=C1C=CC=C2)CC3=CC=C(\\C=C\\C(=O)NO)C=C3",3.045,1,3,9]
["S1096","Quisinostat (JNJ-26481585) 2HCl","f8","L6200-01","in 10mM DMSO","HDAC","Epigenetics","Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.",467.39,"875320-31-3",{"v":79,"d":"79.00"},169.02,"<1","N/A","http://selleckchem.com/products/JNJ-26481585.html","C21H28Cl2N6O2","Dihydrochloride","N/A","Cl.Cl.C[N]1C=C(CNCC2CCN(CC2)C3=NC=C(C=N3)C(=O)NO)C4=CC=CC=C14",2.749,3,2,6]
["S1098","Rucaparib (AG-014699) phosphate","g8","L6200-01","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3.",421.36,"459868-92-9",{"v":84,"d":"84.00"},199.35,"<1","N/A","http://selleckchem.com/products/AG-014699.html","C19H18FN3O.H3PO4","Phosphate","PF-01367338","CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)[NH]2)F.O[P](O)(O)=O",{"v":2.49,"d":"2.490"},1,3,3]
["S1100","MLN8054","h8","L6200-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM in Sf9 insect cell. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.",476.86,"869363-13-3",{"v":95,"d":"95.00"},199.22,"<1","N/A","http://selleckchem.com/products/MLN8054.html","C25H15ClF2N4O2","free base","N/A","OC(=O)C1=CC=C(NC2=NC3=C(CN=C(C4=CC(=CC=C34)Cl)C5=C(F)C=CC=C5F)C=N2)C=C1",6.192,4,1,4]
["S1102","U0126-EtOH","a9","L6200-01","in 10mM DMSO","Antiviral,Autophagy,MEK,Mitophagy","MAPK","U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.",426.56,"1173097-76-1",{"v":85,"d":"85.00"},199.27,"<1","N/A","http://selleckchem.com/products/U0126.html","C18H16N6S2.C2H6O","Ethanolate","N/A","CCO.N\\C(SC1=CC=CC=C1N)=C(C#N)\\C(C#N)=C(N)/SC2=CC=CC=C2N",2.169,0,5,5]
["S1103","ZM 447439","b9","L6200-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.",513.59,"331771-20-1",{"v":103,"d":"103.00"},200.55,"<1","N/A","http://selleckchem.com/products/ZM-447439.html","C29H31N5O4","free base","N/A","COC1=C(OCCCN2CCOCC2)C=C3N=CN=C(NC4=CC=C(NC(=O)C5=CC=CC=C5)C=C4)C3=C1",4.118,6,2,10]
["S1105","LY294002","c9","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase,DNA-PK,PI3K","PI3K/Akt/mTOR","LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.",307.34,"154447-36-6",{"v":36,"d":"36.00"},117.13,"<1","N/A","http://selleckchem.com/products/LY294002.html","C19H17NO3","free base","SF 1101, NSC 697286","O=C1C=C(OC2=C(C=CC=C12)C3=CC=CC=C3)N4CCOCC4",3.342,3,0,2]
["S1106","OSU-03012 (AR-12)","d9","L6200-01","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.",460.45,"742112-33-0",{"v":11,"d":"11.00"},23.89,"<1","N/A","http://selleckchem.com/products/OSU-03012.html","C26H19F3N4O","free base","N/A","NCC(=O)NC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC4=C(C=C3)C5=C(C=CC=C5)C=C4)C(F)(F)F",5.212,2,2,5]
["S1107","Danusertib (PHA-739358)","e9","L6200-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy,Bcr-Abl,c-RET,FGFR,Trk receptor","Cell Cycle","Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.",474.55,"827318-97-8",{"v":95,"d":"95.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHA-739358(Danusertib).html","C26H30N6O3","free base","N/A","COC(C(=O)N1CC2=C(C1)C(=N[NH]2)NC(=O)C3=CC=C(C=C3)N4CCN(C)CC4)C5=CC=CC=C5",2.337,4,2,6]
["S1109","BI 2536","f9","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Myc,PLK","Cell Cycle","BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.",521.66,"755038-02-9",{"v":21,"d":"21.00"},40.26,"<1","N/A","http://selleckchem.com/products/BI-2536.html","C28H39N7O3","free base","N/A","CCC1N(C2CCCC2)C3=NC(=NC=C3N(C)C1=O)NC4=CC=C(C=C4OC)C(=O)NC5CCN(C)CC5",3.548,5,2,7]
["S1113","GSK690693","g9","L6200-01","in 10mM DMSO","Akt,AMPK,Autophagy,DAPK,PKA,PKC,STING,ULK","PI3K/Akt/mTOR","GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.",425.48,"937174-76-0",{"v":39,"d":"39.00"},91.66,"<1","N/A","http://selleckchem.com/products/GSK690693.html","C21H27N7O3","free base","N/A","CC[N]1C(=NC2=C1C(=CN=C2C#CC(C)(C)O)OCC3CCCNC3)C4=NON=C4N",1.839,6,2,7]
["S1115","Odanacatib (MK-0822)","h9","L6200-01","in 10mM DMSO","Cysteine Protease","Proteases","Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.",525.56,"603139-19-1",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/Odanacatib-(MK0822).html","C25H27F4N3O3S","free base","N/A","CC(C)(F)CC(NC(C1=CC=C(C=C1)C2=CC=C(C=C2)[S](C)(=O)=O)C(F)(F)F)C(=O)NC3(CC3)C#N",3.978,3,2,10]
["S1117","Triciribine (NSC 154020)","a10","L6200-01","in 10mM DMSO","Akt,DNA/RNA Synthesis,HIV","PI3K/Akt/mTOR","Triciribine (NSC 154020, VD-0002, vqd-002, API-2, TCN) is a DNA synthesis inhibitor, also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.",{"v":320.3,"d":"320.30"},"35943-35-2",{"v":64,"d":"64.00"},199.81,"<1","N/A","http://selleckchem.com/products/Triciribine.html","C13H16N6O4","free base","VD-0002, vqd-002, API-2, TCN","CN1N=C(N)C2=C[N](C3OC(CO)C(O)C3O)C4=C2C1=NC=N4",-1.119,4,4,2]
["S1120","Everolimus (RAD001)","b10","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1","N/A","http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1122","Mocetinostat (MGCD0103)","c10","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.",396.44,"726169-73-9",{"v":13,"d":"13.00"},32.79,"<1","N/A","http://selleckchem.com/products/MGCD0103(Mocetinostat).html","C23H20N6O","free base","MG0103","NC1=CC=CC=C1NC(=O)C2=CC=C(CNC3=NC=CC(=N3)C4=CC=CN=C4)C=C2",2.798,4,3,6]
["S1124","BMS-754807","d10","L6200-01","in 10mM DMSO","c-Met,IGF-1R,RON,Trk receptor","Protein Tyrosine Kinase","BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.",461.49,"1001350-96-4",{"v":92,"d":"92.00"},199.35,"<1","N/A","http://selleckchem.com/products/BMS-754807.html","C23H24FN9O","free base","N/A","CC1(CCCN1C2=N[N]3C=CC=C3C(=N2)NC4=N[NH]C(=C4)C5CC5)C(=O)NC6=CC=C(F)N=C6",4.069,5,3,6]
["S1129","SRT1720 HCl","e10","L6200-01","in 10mM DMSO","Autophagy,Sirtuin","Epigenetics","SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.",506.02,"1001645-58-4",{"v":38,"d":"38.00"},{"v":75.1,"d":"75.10"},"<1","N/A","http://selleckchem.com/products/SRT1720.html","C25H23N7OS.HCl","Hydrochloride","N/A","Cl.O=C(NC1=CC=CC=C1C2=C[N]3C(=CSC3=N2)CN4CCNCC4)C5=NC6=CC=CC=C6N=C5",3.018,4,2,5]
["S1130","Sepantronium Bromide","f10","L6200-01","in 10mM DMSO","Autophagy,IAP,Survivin","Apoptosis","Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.",443.29,"781661-94-7",{"v":55,"d":"55.00"},124.07,{"v":89,"d":"89.00"},200.77,"http://selleckchem.com/products/YM155.html","C20H19BrN4O3","Bromide","YM155","[Br-].COCC[N]1C(=[N+](CC2=CN=CC=N2)C3=C1C(=O)C4=C(C=CC=C4)C3=O)C",-0.733,5,0,5]
["S1132","3-Aminobenzamide","g10","L6200-01","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.",136.15,"3544-24-9",{"v":27,"d":"27.00"},198.31,"<1","N/A","https://www.selleckchem.com/products/3-aminobenzamide.html","C7H8N2O","free base","3-ABA , 3-amino Benzamide, 3-AB","NC(=O)C1=CC(=CC=C1)N",0.085,1,2,1]
["S1133","Alisertib (MLN8237)","h10","L6200-01","in 10mM DMSO","Apoptosis related,Aurora Kinase,Autophagy","Cell Cycle","Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.",518.92,"1028486-01-2",{"v":27,"d":"27.00"},52.03,"<1","N/A","http://selleckchem.com/products/MLN8237.html","C27H20ClFN4O4","free base","N/A","COC1=C(C(=CC=C1)F)C2=NCC3=C(N=C(NC4=CC(=C(C=C4)C(O)=O)OC)N=C3)C5=C2C=C(Cl)C=C5",5.954,6,1,6]
["S1134","AT9283","a11","L6200-01","in 10mM DMSO","Aurora Kinase,Bcr-Abl,JAK","JAK/STAT","AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I).",381.43,"896466-04-9",{"v":76,"d":"76.00"},199.25,"<1","N/A","http://selleckchem.com/products/AT9283.html","C19H23N7O2","free base","N/A","O=C(NC1CC1)NC2=C[NH]N=C2C3=NC4=CC(=CC=C4[NH]3)CN5CCOCC5",{"v":1.51,"d":"1.510"},4,4,5]
["S1138","Brivanib Alaninate (BMS-582664)","b11","L6200-01","in 10mM DMSO","FGFR,VEGFR","Protein Tyrosine Kinase","Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.",441.46,"649735-63-7",{"v":88,"d":"88.00"},199.34,"<1","N/A","http://selleckchem.com/products/Brivanib-alaninate.html","C22H24FN5O4","Alaninate","N/A","CC(N)C(=O)OC(C)COC1=C[N]2N=CN=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)C2=C1C",3.383,6,2,8]
["S1141","Tanespimycin (17-AAG)","c11","L6200-01","in 10mM DMSO","Apoptosis related,Autophagy,HSP (HSP90),Mitophagy","Cytoskeletal Signaling","Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.",585.69,"75747-14-7",{"v":100,"d":"100.00"},170.74,"<1","N/A","http://selleckchem.com/products/17-AAG(Geldanamycin).html","C31H43N3O8","free base","CP127374, NSC-330507, KOS 953","COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.524,7,4,7]
["S1142","Alvespimycin (17-DMAG) HCl","d11","L6200-01","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay.",653.21,"467214-21-7",{"v":131,"d":"131.00"},200.55,"<1","N/A","http://selleckchem.com/products/17-DMAG,Hydrochloride-Salt.html","C32H48N4O8.HCl","Hydrochloride","NSC 707545,BMS 826476 HCl,KOS 1022","Cl.COC1CC(C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(=C\\C=C/C(OC)C(OC(N)=O)/C(=C/C(C)C1O)C)\\C)C2=O",2.428,7,4,8]
["S1143","AG-490 (Tyrphostin B42)","e11","L6200-01","in 10mM DMSO","EGFR,JAK","Protein Tyrosine Kinase","AG-490 (Tyrphostin B42, Zinc02557947) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.",{"v":294.3,"d":"294.30"},"133550-30-8",{"v":58,"d":"58.00"},197.08,"<1","N/A","http://selleckchem.com/products/AG-490.html","C17H14N2O3","free base","Zinc02557947","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NCC2=CC=CC=C2",2.444,1,3,4]
["S1145","SNS-032 (BMS-387032)","f11","L6200-01","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.",380.53,"345627-80-7",{"v":76,"d":"76.00"},199.72,"<1","N/A","http://selleckchem.com/products/SNS-032.html","C17H24N4O2S2","free base","N/A","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1",{"v":2.07,"d":"2.070"},4,2,6]
["S1147","Barasertib (AZD1152-HQPA)","g11","L6200-01","in 10mM DMSO","Aurora Kinase","Cell Cycle","Defosbarasertib (AZD1152-HQPA, AZD2811, INH-34, Barasertib-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.",507.56,"722544-51-6",{"v":102,"d":"102.00"},200.96,"<1","N/A","http://selleckchem.com/products/AZD1152-HQPA.html","C26H30FN7O3","free base","AZD2811, INH-34, Barasertib-HQPA , Defosbarasertib","CCN(CCO)CCCOC1=CC=C2C(=NC=NC2=C1)NC3=CC(=N[NH]3)CC(=O)NC4=CC=CC(=C4)F",3.493,5,4,13]
["S1148","Docetaxel (RP56976)","h11","L6200-01","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",807.88,"114977-28-5",{"v":100,"d":"100.00"},123.78,"<1","N/A","http://selleckchem.com/products/Docetaxel(Taxotere).html","C43H53NO14","Free Base","NSC 628503,RP56976","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",2.586,10,4,13]
["S1150","Paclitaxel (NSC 125973)","a2","L6200-02","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.",853.91,"33069-62-4",{"v":171,"d":"171.00"},200.26,"<1","N/A","http://selleckchem.com/products/Paclitaxel(Taxol).html","C47H51NO14","free base","PTX, Taxol, Onxal, Abraxane,NSC 125973","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S1153","Roscovitine (CYC202)","b2","L6200-02","in 10mM DMSO","CDK","Cell Cycle","Roscovitine (CYC202, Seliciclib, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6. Phase 2.",354.45,"186692-46-6",{"v":71,"d":"71.00"},200.31,"<1","N/A","http://selleckchem.com/products/Roscovitine.html","C19H26N6O","free base","Seliciclib, R-roscovitine","CCC(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=CC=C3",{"v":3.32,"d":"3.320"},3,3,8]
["S1154","SNS-314","c2","L6200-02","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.",430.93,"1057249-41-8",{"v":105,"d":"105.00"},243.66,{"v":6,"d":"6.00"},13.92,"http://selleckchem.com/products/sns-314-mesylate.html","C18H15ClN6OS2","Mesylate","N/A","C[S](O)(=O)=O.ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.539,4,3,6]
["S1155","S3I-201","d2","L6200-02","in 10mM DMSO","STAT","JAK/STAT","S3I-201 (NSC 74859) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.",365.36,"501919-59-1",{"v":73,"d":"73.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/S31-201.html","C16H15NO7S","free base","NSC 74859","CC1=CC=C(C=C1)[S](=O)(=O)OCC(=O)NC2=CC=C(C(O)=O)C(=C2)O",1.712,3,2,6]
["S1156","Capecitabine (RO 09-1978)","e2","L6200-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis","DNA Damage/DNA Repair","Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.",359.35,"154361-50-9",{"v":72,"d":"72.00"},200.36,{"v":6,"d":"6.00"},{"v":16.7,"d":"16.70"},"http://selleckchem.com/products/Capecitabine(Xeloda).html","C15H22FN3O6","free base","RO 09-1978","CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2OC(C)C(O)C2O",{"v":0.82,"d":"0.820"},5,3,7]
["S1157","Delanzomib (CEP-18770)","f2","L6200-02","in 10mM DMSO","Proteasome","Proteases","Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2.",413.28,"847499-27-8",{"v":83,"d":"83.00"},200.83,"<1","N/A","http://selleckchem.com/products/cep-18770.html","C21H28BN3O5","free base","N/A","CC(C)C(CNC(=O)C(NC(=O)C1=NC(=CC=C1)C2=CC=CC=C2)C(C)O)B(O)O",2.646,3,3,9]
["S1159","Ganetespib (STA-9090)","g2","L6200-02","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474. Phase 3.",{"v":364.4,"d":"364.40"},"888216-25-9",{"v":40,"d":"40.00"},109.77,"<1","N/A","http://selleckchem.com/products/ganetespib-sta-9090.html","C20H20N4O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)[N](C)C=C4",3.866,2,3,3]
["S1163","Onalespib (AT13387)","h2","L6200-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.",409.52,"912999-49-6",{"v":25,"d":"25.00"},61.05,"<1","N/A","http://selleckchem.com/products/at13387.html","C24H31N3O3","free base","N/A","CC(C)C1=C(O)C=C(O)C(=C1)C(=O)N2CC3=C(C2)C=C(CN4CCN(C)CC4)C=C3",3.322,1,2,4]
["S1165","ABT-751 (E7010)","a3","L6200-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.",371.41,"141430-65-1",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/ABT-751.html","C18H17N3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NC2=C(NC3=CC=C(O)C=C3)N=CC=C2",2.997,4,3,6]
["S1168","Valproic Acid (NSC 93819) sodium salt","b3","L6200-02","in 10mM DMSO","Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1α","Neuronal Signaling","Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.",166.19,"1069-66-5",{"v":33,"d":"33.00"},198.57,{"v":33,"d":"33.00"},198.57,"http://selleckchem.com/products/Sodium-valproate.html","C8H15NaO2","Sodium salt","Sodium valproate,NSC 93819,2-Propylpentanoic Acid","CCCC(CCC)C(=O)O[Na]",1.275,0,0,5]
["S1169","TGX-221","c3","L6200-02","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, 1000-fold more selective for p110β than p110α.",364.44,"663619-89-4",{"v":12,"d":"12.00"},32.93,"<1","N/A","http://selleckchem.com/products/TGX-221.html","C21H24N4O2","free base","N/A","CC(NC1=CC=CC=C1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.373,3,1,4]
["S1171","CYC116","d3","L6200-02","in 10mM DMSO","Aurora Kinase,VEGFR","Cell Cycle","CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.",368.46,"693228-63-6",{"v":24,"d":"24.00"},65.14,"<1","N/A","http://selleckchem.com/products/CYC116.html","C18H20N6OS","free base","N/A","CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.743,4,2,4]
["S1172","Serdemetan (JNJ-26854165)","e3","L6200-02","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1175","BIIB021","f3","L6200-02","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","BIIB021 (CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.",318.76,"848695-25-0",{"v":64,"d":"64.00"},200.78,"<1","N/A","http://selleckchem.com/products/BIIB021.html","C14H15ClN6O","free base","CNF2024","COC1=C(C)C=NC(=C1C)C[N]2C=NC3=C(Cl)N=C(N)N=C23",2.223,5,1,3]
["S1176","Plinabulin (NPI-2358)","g3","L6200-02","in 10mM DMSO","Microtubule Associated,VDA","Angiogenesis","Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.",336.39,"714272-27-2",{"v":54,"d":"54.00"},160.53,"<1","N/A","http://selleckchem.com/products/NPI-2358.html","C19H20N4O2","free base","N/A","CC(C)(C)C1=C(/C=C/2NC(=O)C(/NC2=O)=C/C3=CC=CC=C3)N=C[NH]1",1.921,3,3,3]
["S1177","PD98059","h3","L6200-02","in 10mM DMSO","AhR,MEK","MAPK","PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.",267.28,"167869-21-8",{"v":14,"d":"14.00"},52.38,"<1","N/A","http://selleckchem.com/products/PD-98059.html","C16H13NO3","free base","N/A","COC1=C(N)C(=CC=C1)C2=CC(=O)C3=CC=CC=C3O2",2.373,3,1,2]
["S1178","Regorafenib (BAY 73-4506)","a4","L6200-02","in 10mM DMSO","Autophagy,c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY 73-4506,Fluoro-Sorafenib, Resihance, Stivarga) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.",482.82,"755037-03-7",{"v":97,"d":"97.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://selleckchem.com/products/BAY-73-4506.html","C21H15ClF4N4O3","free base","Fluoro-Sorafenib, Resihance, Stivarga,BAY 73-4506","CNC(=O)C1=CC(=CC=N1)OC2=CC(=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)F",4.381,4,3,6]
["S1180","XAV-939","b4","L6200-02","in 10mM DMSO","PARP,Wnt/beta-catenin","Stem Cells & Wnt","XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.",312.31,"284028-89-3",{"v":12,"d":"12.00"},38.42,"<1","N/A","http://selleckchem.com/products/XAV-939.html","C14H11F3N2OS","free base","NVP-XAV939","OC1=C2CSCCC2=NC(=N1)C3=CC=C(C=C3)C(F)(F)F",3.676,2,1,2]
["S1181","ENMD-2076","c4","L6200-02","in 10mM DMSO","Apoptosis related,Aurora Kinase,CSF-1R,FGFR,FLT3,PDGFR,Src,VEGFR","Angiogenesis","ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.",375.47,"934353-76-1",{"v":105,"d":"105.00"},279.65,{"v":1,"d":"1.00"},2.66,"http://selleckchem.com/products/enmd-2076.html","C21H25N7","Tartaric Acid","N/A","CN1CCN(CC1)C2=CC(=NC(=N2)\\C=C\\C3=CC=CC=C3)NC4=N[NH]C(=C4)C",4.015,3,2,5]
["S1183","Danoprevir (ITMN-191)","d4","L6200-02","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Danoprevir (ITMN-191, RG7227) is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. Phase 2.",731.83,"850876-88-9",{"v":144,"d":"144.00"},196.77,"<1","N/A","http://selleckchem.com/products/Danoprevir.html","C35H46FN5O9S","free base","RG7227","CC(C)(C)OC(=O)NC1CCCCC\\C=C/C2CC2(NC(=O)C3CC(CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)N[S](=O)(=O)C6CC6",2.922,9,3,8]
["S1185","Ritonavir (ABT-538)","e4","L6200-02","in 10mM DMSO","Apoptosis related,COVID-19,HIV Protease,P450 (e.g. CYP17)","Proteases","Ritonavir (ABT-538, A 84538, RTV, Norvir, Norvir Softgel) is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases. Ritonavir induces apoptosis.",720.94,"155213-67-5",{"v":100,"d":"100.00"},138.71,"<1","N/A","http://selleckchem.com/products/Ritonavir.html","C37H48N6O5S2","free base","ABT-538,A 84538, RTV, Norvir, Norvir Softgel","CC(C)C(NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)CC4=CC=CC=C4",4.978,6,4,18]
["S1186","BIBR 1532","f4","L6200-02","in 10mM DMSO","Apoptosis related,Telomerase","DNA Damage/DNA Repair","BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.",331.36,"321674-73-1",{"v":66,"d":"66.00"},199.18,"<1","N/A","http://selleckchem.com/products/BIBR1532.html","C21H17NO3","free base","N/A","CC(=C\\C(=O)NC1=C(C=CC=C1)C(O)=O)/C2=CC3=CC=CC=C3C=C2",4.067,2,1,4]
["S1190","Bicalutamide (ICI-176334)","g4","L6200-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Bicalutamide (ICI-176334) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM in LNCaP/AR(cs)cell line. Bicalutamide promotes autophagy.",430.37,"90357-06-5",{"v":86,"d":"86.00"},199.83,"<1","N/A","http://selleckchem.com/products/Bicalutamide(Casodex).html","C18H14F4N2O4S","free base","ICI-176334","CC(O)(C[S](=O)(=O)C1=CC=C(F)C=C1)C(=O)NC2=CC=C(C#N)C(=C2)C(F)(F)F",2.926,3,1,6]
["S1191","Fulvestrant (ICI-182780)","h4","L6200-02","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor","Endocrinology & Hormones","Fulvestrant (ICI-182780, ZD 9238, ZM 182780) is an estrogen receptor (ER) antagonist with IC50 of 0.94 nM in a cell-free assay. Fulvestrant also induces autophagy and apoptosis and has antitumor activity.",606.77,"129453-61-8",{"v":100,"d":"100.00"},164.81,"<1","N/A","http://selleckchem.com/products/Fulvestrant.html","C32H47F5O3S","free base","ICI-182780, ZD 9238, ZM 182780","CC12CCC3C(C(CCCCCCCCC[S](=O)CCCC(F)(F)C(F)(F)F)CC4=C3C=CC(=C4)O)C1CCC2O",8.437,1,2,15]
["S1192","Raltitrexed","a5","L6200-02","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.",458.49,"112887-68-0",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/Raltitrexed.html","C21H22N4O6S","free base","ZD-1694, ICI-D1694, D1694","CN(CC1=CC2=C(C=C1)N=C(C)NC2=O)C3=CC=C(S3)C(=O)NC(CCC(O)=O)C(O)=O",1.528,5,2,9]
["S1193","Thalidomide (K17)","b5","L6200-02","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.",258.23,"50-35-1",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Thalidomide.html","C13H10N2O4","free base","K17","O=C1CCC(N2C(=O)C3=C(C=CC=C3)C2=O)C(=O)N1",0.097,4,1,1]
["S1194","CUDC-101","c5","L6200-02","in 10mM DMSO","EGFR,HDAC,HER2","Epigenetics","CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.",434.49,"1012054-59-9",{"v":20,"d":"20.00"},46.03,"<1","N/A","http://selleckchem.com/products/CUDC-101.html","C24H26N4O4","free base","N/A","COC1=CC2=C(C=C1OCCCCCCC(=O)NO)C(=NC=N2)NC3=CC(=CC=C3)C#C",5.376,5,2,11]
["S1197","Finasteride","d5","L6200-02","in 10mM DMSO","5-alpha Reductase","Endocrinology & Hormones","Finasteride (MK-906) is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).",372.54,"98319-26-7",{"v":75,"d":"75.00"},201.32,"<1","N/A","http://selleckchem.com/products/Finasteride.html","C23H36N2O2","free base","MK-906","CC(C)(C)NC(=O)C1CCC2C3CCC4NC(=O)C=CC4(C)C3CCC12C",3.174,2,2,2]
["S1199","Cladribine (RWJ 26251)","e5","L6200-02","in 10mM DMSO","Adenosine Deaminase,DNA/RNA Synthesis","Neuronal Signaling","Cladribine (RWJ 26251, Leustatin, 2-CdA, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, CldAdo, Jk 6251, NSC 105014) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.",285.69,"4291-63-8",{"v":57,"d":"57.00"},199.52,"<1","N/A","http://selleckchem.com/products/Cladribine.html","C10H12ClN5O3","free base","Leustatin,2-CdA,2-Chloro-2′-deoxyadenosine,CldAdo,Jk 6251,NSC 105014,RWJ 26251","NC1=NC(=NC2=C1N=C[N]2C3CC(O)C(CO)O3)Cl",-0.259,4,3,2]
["S1200","Decitabine (NSC 127716)","f5","L6200-02","in 10mM DMSO","Apoptosis related,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","Epigenetics","Decitabine (Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.",228.21,"2353-33-5",{"v":45,"d":"45.00"},197.19,{"v":10,"d":"10.00"},43.82,"http://selleckchem.com/products/Decitabine.html","C8H12N4O4","free base","Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716","NC1=NC(=O)N(C=N1)C2CC(O)C(CO)O2",-1.093,4,3,2]
["S1202","Dutasteride","g5","L6200-02","in 10mM DMSO","5-alpha Reductase","Endocrinology & Hormones","Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).",528.53,"164656-23-9",{"v":62,"d":"62.00"},117.31,"<1","N/A","http://selleckchem.com/products/Dutasteride.html","C27H30F6N2O2","free base","GI198745, GG-745","CC12CCC3C(CCC4NC(=O)C=CC34C)C1CCC2C(=O)NC5=CC(=CC=C5C(F)(F)F)C(F)(F)F",5.703,2,2,4]
["S1204","Melatonin (NSC 113928)","h5","L6200-02","in 10mM DMSO","Apoptosis related,ATF/CREB & c-Fos/c-Jun,Autophagy,COX,Mitophagy,MT Receptor","GPCR & G Protein","Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.",232.28,"73-31-4",{"v":47,"d":"47.00"},202.34,"<1","N/A","http://selleckchem.com/products/Melatonin.html","C13H16N2O2","free base","NSC 56423, N-Acetyl-5-methoxytryptamine,NSC 113928,MT","COC1=CC2=C([NH]C=C2CCNC(C)=O)C=C1",1.555,2,2,4]
["S1208","Doxorubicin (Adriamycin) HCl","a6","L6200-02","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1209","Fluorouracil (5-Fluorouracil, 5-FU)","b6","L6200-02","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,HIV,Nucleoside Analog/Antimetabolite,Thymidylate Synthase","DNA Damage/DNA Repair","Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.",130.08,"51-21-8",{"v":26,"d":"26.00"},199.88,"<1","N/A","http://selleckchem.com/products/Adrucil(Fluorouracil).html","C4H3FN2O2","free base","NSC 19893,5-Fluorouracil, 5-FU","FC1=CNC(=O)NC1=O",-1.102,2,2,0]
["S1210","Methotrexate (CL-14377)","c6","L6200-02","in 10mM DMSO","ADC Cytotoxin,DHFR","Metabolism","Methotrexate (CL14377, MTX, NCI-C04671, Amethopterin, WR19039, abitrexate), analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.",454.44,"59-05-2",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/Abitrexate.html","C20H22N8O5","free base","NCI-C04671, Amethopterin, CL14377, WR19039, abitrexate","CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",0.114,7,3,9]
["S1212","Bendamustine (SDX105) HCl","d6","L6200-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bendamustine (SDX-105, Cytostasane) HCl is a DNA-damaging agent with IC50 of 50 μM in cell-free assay.",394.72,"3543-75-7",{"v":78,"d":"78.00"},197.61,{"v":2,"d":"2.00"},5.07,"http://selleckchem.com/products/Bendamustine-Hydrochloride.html","C16H21Cl2N3O2.HCl","Hydrochloride","Cytostasane HCl","Cl.C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCC(O)=O",3.988,2,0,9]
["S1213","Nelarabine","e6","L6200-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.",297.27,"121032-29-9",{"v":60,"d":"60.00"},201.84,{"v":3,"d":"3.00"},10.09,"http://selleckchem.com/products/Arranon.html","C11H15N5O5","free base","506U78,Arranon","COC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)N",-1.376,5,4,3]
["S1214","Bleomycin (NSC125066) sulfate","f6","L6200-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Bleomycin Sulfate (Blenoxane,NSC125066) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.",1512.62,"9041-93-4",{"v":100,"d":"100.00"},{"v":66,"d":"66.00"},"N/A","N/A","http://www.selleckchem.com/products/Bleomycin-sulfate.html","C55H85N17O25S4","Sulfate","Blenoxane,NSC125066","CC(O)C(NC(=O)C(C)C(O)C(C)NC(=O)C(NC(=O)C1=C(C)C(=NC(=N1)C(CC(N)=O)NCC(N)C(N)=O)N)C(OC2OC(CO)C(O)C(O)C2OC3OC(CO)C(O)C(OC(N)=O)C3O)C4=C[NH]C=N4)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C.O[S]([O-])(=O)=O","N/A","N/A","N/A","N/A"]
["S1216","PFI-1 (PF-6405761)","g6","L6200-02","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-1 (PF-6405761) is a highly selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM and for BRD2 with IC50 of 98 nM in a cell-free assay.",347.39,"1403764-72-6",{"v":69,"d":"69.00"},198.62,"<1","N/A","http://selleckchem.com/products/pfl-1.html","C16H17N3O4S","free base","N/A","COC1=C(C=CC=C1)[S](=O)(=O)NC2=CC=C3NC(=O)N(C)CC3=C2",1.376,4,2,4]
["S1218","Clofarabine","h6","L6200-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Clofarabine (Clolar) inhibits the enzymatic activities of ribonucleotide reductase (RNR) (IC50 = 65 nM) and DNA polymerase. Clofarabine induces autophagy and apoptosis.",303.68,"123318-82-1",{"v":60,"d":"60.00"},197.58,"<1","N/A","http://selleckchem.com/products/Clofarabine.html","C10H11ClFN5O3","free base","Clolar","NC1=C2N=C[N](C3OC(CO)C(O)C3F)C2=NC(=N1)Cl",-0.085,4,3,2]
["S1219","YM201636","a7","L6200-02","in 10mM DMSO","Autophagy,PI3K,PIKfyve","PI3K/Akt/mTOR","YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue). YM-201636 suppresses the growth of liver cancer via the induction of autophagy.",467.48,"371942-69-7",{"v":35,"d":"35.00"},74.87,"<1","N/A","http://selleckchem.com/products/ym201636.html","C25H21N7O3","free base","N/A","NC1=CC=C(C=N1)C(=O)NC2=CC=CC(=C2)C3=NC(=C4OC5=NC=CC=C5C4=N3)N6CCOCC6",2.467,7,2,4]
["S1221","Dacarbazine (NSC-45388)","b7","L6200-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.",182.18,"4342-03-4",{"v":12,"d":"12.00"},65.87,{"v":2,"d":"2.00"},10.98,"http://selleckchem.com/products/Dacarbazine.html","C6H10N6O","free base","DTIC-Dome, Imidazole Carboxamide,NSC-45388","CN(C)N=NC1=C(N=C[NH]1)C(N)=O",-0.344,4,2,3]
["S1222","Dexrazoxane HCl (ICRF-187)","c7","L6200-02","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Dexrazoxane HCl (ADR-529,Totect, ICRF-187, Zinecard, Cardioxane) is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent; also an inhibitor of topoisomerase II",304.73,"149003-01-0",{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},{"v":60,"d":"60.00"},{"v":196.9,"d":"196.90"},"http://selleckchem.com/products/Dexrazoxane-Hydrochloride.html","C11H16N4O4.HCl","Hydrochloride","ADR-529,Totect, ICRF-187, Zinecard, Cardioxane","Cl.CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2",-1.722,4,2,3]
["S1223","Epirubicin (IMI 28) HCl","d7","L6200-02","in 10mM DMSO","Apoptosis related,Topoisomerase","DNA Damage/DNA Repair","Epirubicin HCl (Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. Epirubicin induces apoptosis.",579.98,"56390-09-1",{"v":100,"d":"100.00"},172.42,{"v":100,"d":"100.00"},172.42,"http://selleckchem.com/products/Ellence.html","C27H29NO11.HCl","Hydrochloride","Ellence, Pharmorubicin, Epirubicin Ebewe,IMI 28, NSC 256942, 4'-epidoxorubicin,Epirubicin hydrochloride","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1225","Etoposide (VP-16)","e7","L6200-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Etoposide (VP-16213,Vepesid,VP-16) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II  inhibition activity. Etoposide induces autophagy, mitophagy and apoptosis.",588.56,"33419-42-0",{"v":100,"d":"100.00"},169.91,"<1","N/A","http://selleckchem.com/products/Etopophos.html","C29H32O13","free base","VP-16213,Vepesid,VP-16","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(C)OC5C(O)C4O)C6=C2C=C7OCOC7=C6",0.935,10,3,5]
["S1226","KU-0063794","f7","L6200-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.",465.54,"938440-64-3",{"v":16,"d":"16.00"},34.37,"<1","N/A","http://selleckchem.com/products/KU-0063794.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=NC(=NC(=C3C=C2)N4CCOCC4)N5CC(C)OC(C)C5",3.274,6,1,5]
["S1227","Raloxifene HCl","g7","L6200-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Raloxifene (LY156758, Keoxifene) HCl is a selective and orally active estrogen receptor modulator (SERM), which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.",510.04,"82640-04-8",{"v":100,"d":"100.00"},196.06,"<1","N/A","http://selleckchem.com/products/Evista.html","C28H27NO4S.HCl","Hydrochloride","LY156758 (Keoxifene) HCl","Cl.OC1=CC=C(C=C1)C2=C(C(=O)C3=CC=C(OCCN4CCCCC4)C=C3)C5=C(S2)C=C(O)C=C5",6.843,2,2,7]
["S1229","Fludarabine Phosphate","h7","L6200-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fludarabine Phosphate (F-ara-A, NSC 312887) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.",365.21,"75607-67-9",{"v":73,"d":"73.00"},199.88,{"v":2,"d":"2.00"},5.48,"http://selleckchem.com/products/Fludara.html","C10H13FN5O7P","Phosphate","F-ara-A (NSC 312887) Phosphate","NC1=NC(=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O)F",-1.384,5,3,4]
["S1230","Flavopiridol (L86-8275)","a8","L6200-02","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol (L86-8275, Alvocidib, NSC 649890, HMR-1275) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.",401.84,"146426-40-6",{"v":15,"d":"15.00"},37.33,"<1","N/A","http://selleckchem.com/products/Flavopiridol.html","C21H20ClNO5","Free Base","NSC 649890 HCl, HMR-1275, Alvocidib","CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",3.108,2,3,2]
["S1231","Topotecan (NSC609699) HCl","b8","L6200-02","in 10mM DMSO","Apoptosis related,Autophagy,Topoisomerase","DNA Damage/DNA Repair","Topotecan HCl (Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.",457.91,"119413-54-6",{"v":91,"d":"91.00"},198.73,{"v":91,"d":"91.00"},198.73,"http://selleckchem.com/products/Topotecan-Hydrochloride.html","C23H23N3O5.HCl","Hydrochloride","Nogitecan HCl, SKFS 104864A,Hycamtin, NSC 609699","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC(=C(CN(C)C)C5=C4)O)C2=O",1.959,4,1,3]
["S1233","2-Methoxyestradiol (2-MeOE2)","c8","L6200-02","in 10mM DMSO","Apoptosis related,Autophagy,HIF,Microtubule Associated","Angiogenesis","2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines.",302.41,"362-07-2",{"v":60,"d":"60.00"},198.41,"<1","N/A","http://selleckchem.com/products/2-Methoxyestradiol(2ME2).html","C19H26O3","free base","NSC 659853, 2-ME2","COC1=C(O)C=C2CCC3C(CCC4(C)C(O)CCC34)C2=C1",3.821,1,2,1]
["S1234","AG-1024","d8","L6200-02","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","AG-1024 (Tyrphostin, AGS 200) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).",305.17,"65678-07-1",{"v":61,"d":"61.00"},199.89,"<1","N/A","http://selleckchem.com/products/ag-1024-tyrphostin.html","C14H13BrN2O","free base","Tyrphostin, AGS 200","CC(C)(C)C1=C(O)C(=CC(=C1)C=C(C#N)C#N)Br",3.922,0,1,2]
["S1235","Letrozole (CGS 20267)","e8","L6200-02","in 10mM DMSO","Aromatase,Autophagy","Endocrinology & Hormones","Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.",{"v":285.3,"d":"285.30"},"112809-51-5",{"v":57,"d":"57.00"},199.79,"<1","N/A","http://selleckchem.com/products/Letrozole.html","C17H11N5","free base","CGS 20267,Femara, Piroxicam","N#CC1=CC=C(C=C1)C([N]2C=NC=N2)C3=CC=C(C=C3)C#N",2.749,2,0,3]
["S1237","Temozolomide (CCRG 81045)","f8","L6200-02","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis","DNA Damage/DNA Repair","Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.",194.15,"85622-93-1",{"v":38,"d":"38.00"},195.72,"<1","N/A","http://selleckchem.com/products/Methazolastone.html","C6H6N6O2","free base","NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal","CN1N=NC2=C(N=C[N]2C1=O)C(N)=O",0.052,5,1,1]
["S1238","Tamoxifen (ICI 46474)","g8","L6200-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,ATPase,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Angiogenesis","Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selective estrogen receptor modulator (SERM). Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis.",371.51,"10540-29-1",{"v":74,"d":"74.00"},199.19,"<1","N/A","http://selleckchem.com/products/Nolvadex.html","C26H29NO","Free Base","ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1241","Vincristine (NSC-67574) sulfate","h8","L6200-02","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induces apoptosis.",923.04,"2068-78-2",{"v":100,"d":"100.00"},108.34,{"v":60,"d":"60.00"},{"v":65,"d":"65.00"},"http://selleckchem.com/products/Vincristine-Sulfate.html","C46H58N4O14S","free base","Leurocristine, Oncovin, NSC-67574, 22-Oxovincaleukoblastine","CCC1(O)CC2CN(CCC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=CC6=C(C=C5OC)N(C=O)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC67C89)C(=O)OC)C1.O[S](O)(=O)=O",3.365,8,1,10]
["S1243","Agomelatine (S20098)","a9","L6200-02","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Agomelatine (Valdoxan, Melitor, Thymanax,S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.",{"v":243.3,"d":"243.30"},"138112-76-2",{"v":48,"d":"48.00"},197.29,"<1","N/A","http://selleckchem.com/products/Agomelatine.html","C15H17NO2","free base","Valdoxan, Melitor, Thymanax,S20098","COC1=CC2=C(CCNC(C)=O)C=CC=C2C=C1",{"v":2.17,"d":"2.170"},2,1,4]
["S1244","Amuvatinib (MP-470)","b9","L6200-02","in 10mM DMSO","Apoptosis related,c-Kit,c-Met,c-RET,FLT3,PDGFR,RAD51","Protein Tyrosine Kinase","Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.",447.51,"850879-09-3",{"v":32,"d":"32.00"},71.51,"<1","N/A","http://selleckchem.com/products/MP-470.html","C23H21N5O3S","free base","HPK 56","S=C(NCC1=CC=C2OCOC2=C1)N3CCN(CC3)C4=NC=NC5=C4OC6=CC=CC=C56",4.867,5,1,5]
["S1245","Latrepirdine 2HCl","c9","L6200-02","in 10mM DMSO","5-HT Receptor,GluR,Histamine Receptor","Neuronal Signaling","Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.",392.37,"97657-92-6",{"v":24,"d":"24.00"},61.17,"<1","N/A","http://selleckchem.com/products/Dimebon.html","C21H25N3.2HCl","Dihydrochloride","N/A","Cl.Cl.CN1CCC2=C(C1)C3=C(C=CC(=C3)C)[N]2CCC4=CC=C(C)N=C4",4.769,1,0,3]
["S1249","JNJ-7706621","d9","L6200-02","in 10mM DMSO","Aurora Kinase,CDK","Cell Cycle","JNJ-7706621 is a pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.",394.36,"443797-96-4",{"v":79,"d":"79.00"},200.32,"<1","N/A","http://selleckchem.com/products/JNJ-7706621.html","C15H12F2N6O3S","free base","N/A","NC1=NC(=N[N]1C(=O)C2=C(F)C=CC=C2F)NC3=CC=C(C=C3)[S](N)(=O)=O",2.226,5,3,4]
["S1250","Enzalutamide (MDV3100)","e9","L6200-02","in 10mM DMSO","Androgen Receptor,Autophagy","Endocrinology & Hormones","Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells. Enzalutamide is shown to increase autophagy.",464.44,"915087-33-1",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/MDV3100.html","C21H16F4N4O2S","free base","MDV3100","CNC(=O)C1=C(F)C=C(C=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC=C(C#N)C(=C3)C(F)(F)F",4.954,2,1,4]
["S1251","Dienogest","f9","L6200-02","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.",311.42,"65928-58-7",{"v":62,"d":"62.00"},199.09,"<1","N/A","http://selleckchem.com/products/Dienogest.html","C20H25NO2","free base","STS 557","CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(O)CC#N",3.046,1,0,1]
["S1255","Nepafenac","g9","L6200-02","in 10mM DMSO","COX","Neuronal Signaling","Nepafenac (AHR 9434, AL 6515) is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.",254.28,"78281-72-8",{"v":50,"d":"50.00"},196.63,"<1","N/A","http://selleckchem.com/products/Nepafenac.html","C15H14N2O2","free base","AHR 9434, AL 6515","NC(=O)CC1=CC=CC(=C1N)C(=O)C2=CC=CC=C2",1.524,2,2,4]
["S1261","Celecoxib (SC 58635)","h9","L6200-02","in 10mM DMSO","COX","Neuronal Signaling","Celecoxib (Celebrex, Celebra,SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.",381.37,"169590-42-5",{"v":76,"d":"76.00"},199.28,"<1","N/A","http://selleckchem.com/products/Celecoxib.html","C17H14F3N3O2S","free base","Celebrex, Celebra,SC 58635","CC1=CC=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)(F)F",4.428,3,1,4]
["S1262","Avagacestat (BMS-708163)","a10","L6200-02","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.",520.88,"1146699-66-2",{"v":104,"d":"104.00"},199.66,"<1","N/A","http://selleckchem.com/products/BMS-708163.html","C20H17ClF4N4O4S","free base","N/A","NC(=O)C(CCC(F)(F)F)N(CC1=C(F)C=C(C=C1)C2=NOC=N2)[S](=O)(=O)C3=CC=C(Cl)C=C3",3.364,6,1,10]
["S1263","Laduviglusib (CHIR-99021)","b10","L6200-02","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.",465.34,"252917-06-9",{"v":10,"d":"10.00"},21.49,"<1","N/A","http://selleckchem.com/products/CHIR-99021.html","C22H18Cl2N8","free base","CT99021","CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=CC=C(C=N3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.476,4,3,7]
["S1266","WYE-354","c10","L6200-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",495.53,"1062169-56-5",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/WYE-354.html","C24H29N7O5","free base","N/A","COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5",1.886,8,1,6]
["S1267","Vemurafenib (PLX4032)","d10","L6200-02","in 10mM DMSO","Autophagy,Raf","MAPK","Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.",489.92,"918504-65-1",{"v":97,"d":"97.00"},197.99,"<1","N/A","http://selleckchem.com/products/PLX-4032.html","C23H18ClF2N3O3S","free base","RG7204, RO5185426,PLX4032","CCC[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CC=C(Cl)C=C4",4.953,4,2,7]
["S1274","BX-795","e10","L6200-02","in 10mM DMSO","Autophagy,IκB/IKK,PDPK1,TBK1","PI3K/Akt/mTOR","BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.",591.47,"702675-74-9",{"v":100,"d":"100.00"},169.07,"<1","N/A","http://selleckchem.com/products/bx-795.html","C23H26IN7O2S","free base","N/A","IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4",3.704,4,4,9]
["S1275","BX-912","f10","L6200-02","in 10mM DMSO","PDK","PI3K/Akt/mTOR","BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.",471.35,"702674-56-4",{"v":94,"d":"94.00"},199.43,"<1","N/A","http://selleckchem.com/products/bx-912.html","C20H23BrN8O","free base","N/A","BrC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCC4=CN=C[NH]4",2.798,4,4,7]
["S1278","Altretamine","g10","L6200-02","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.",210.28,"645-05-6",{"v":15,"d":"15.00"},71.33,"<1","N/A","http://selleckchem.com/products/Altretamine.html","C9H18N6","free base","Hexamethylmelamine, NSC13875, ENT50852","CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C",1.995,3,0,3]
["S1282","Artemisinin","h10","L6200-02","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.",282.33,"63968-64-9",{"v":57,"d":"57.00"},201.89,"<1","N/A","http://selleckchem.com/products/Artemisinin.html","C15H22O5","free base","Qinghaosu,Artemisinine,Coartem,NSC 369397","CC1CCC2C(C)C(=O)OC3OC4(C)CCC1C23OO4",1.998,5,0,0]
["S1289","Carmofur","a11","L6200-02","in 10mM DMSO","COVID-19,DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.",257.26,"61422-45-5",{"v":52,"d":"52.00"},202.13,"<1","N/A","http://selleckchem.com/products/Carmofur.html","C11H16FN3O3","free base","HCFU","CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O",1.125,3,2,5]
["S1290","Celastrol (NSC 70931)","b11","L6200-02","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1292","Chelerythrine Chloride (NSC 646662)","c11","L6200-02","in 10mM DMSO","PKC","TGF-beta/Smad","Chelerythrine Chloride (NSC 646662, Broussonpapyrine) is a potent, selective antagonist of PKC with IC50 of 0.66 μM.",384.83,"3895-92-9",{"v":4,"d":"4.00"},10.39,"<1","N/A","http://www.selleck.cn/products/Chelerythrine-chloride.html","C21H18NO4.HCl","Chloride","Broussonpapyrine chloride","Cl.COC1=CC=C2C(=C1OC)C=[N+](C)C3=C2C=CC4=C3C=C5OCOC5=C4",4.568,4,0,2]
["S1294","Cilostazol (OPC-13013)","d11","L6200-02","in 10mM DMSO","PDE","Metabolism","Cilostazol (Pletal,OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.",369.46,"73963-72-1",{"v":74,"d":"74.00"},200.29,"<1","N/A","http://selleckchem.com/products/Cilostazol.html","C20H27N5O2","free base","Pletal,OPC-13013","O=C1CCC2=C(N1)C=CC(=C2)OCCCCC3=NN=N[N]3C4CCCCC4",{"v":3.23,"d":"3.230"},5,1,7]
["S1297","Epothilone A","e11","L6200-02","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.",493.66,"152044-53-6",{"v":99,"d":"99.00"},200.54,"<1","N/A","http://selleckchem.com/products/Epothilone-A.html","C26H39NO6S","free base","N/A","CC1CCCC2OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.574,5,2,2]
["S1299","Floxuridine (NSC 27640)","f11","L6200-02","in 10mM DMSO","Apoptosis related,CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Floxuridine (NSC 27640, Deoxyfluorouridine, FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.",246.19,"50-91-9",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/Floxuridine.html","C9H11FN2O5","free base","Deoxyfluorouridine, FUDR,NSC 27640","OCC1OC(CC1O)N2C=C(F)C(=O)NC2=O",-1.775,3,3,2]
["S1300","Tegafur (FT-207)","g11","L6200-02","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Tegafur (NSC 148958,Fluorafur,FT-207) is a substance being used in the treatment of some types of cancer.",200.17,"17902-23-7",{"v":40,"d":"40.00"},199.83,{"v":8,"d":"8.00"},39.97,"http://selleckchem.com/products/Ftorafur.html","C8H9FN2O3","free base","NSC 148958,Fluorafur,FT-207","FC1=CN(C2CCCO2)C(=O)NC1=O",-0.625,3,1,1]
["S1302","Ifosfamide (NSC109724)","h11","L6200-02","in 10mM DMSO","DNA alkylator,DNA/RNA Synthesis","DNA Damage/DNA Repair","Ifosfamide (Mitoxana, Ifex,Isophosphamide,NSC109724) is a nitrogen mustard alkylating agent used in the treatment of cancer.",261.09,"3778-73-2",{"v":52,"d":"52.00"},199.17,{"v":52,"d":"52.00"},199.17,"http://selleckchem.com/products/Ifosfamide.html","C7H15Cl2N2O2P","free base","Mitoxana, Ifex,Isophosphamide,NSC109724","ClCCN[P]1(=O)OCCCN1CCCl",0.144,2,1,5]
["S1305","Mercaptopurine (6-MP)","a2","L6200-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mercaptopurine(6-MP) is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",152.18,"50-44-2",{"v":30,"d":"30.00"},197.13,"<1","N/A","http://selleckchem.com/products/Mercaptopurine.html","C5H4N4S","free base","6-MP","S=C1N=CNC2=C1[NH]C=N2",0.367,2,2,0]
["S1319","Costunolide","b2","L6200-03","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.",232.32,"553-21-9",{"v":47,"d":"47.00"},202.31,"<1","N/A","http://selleckchem.com/products/Costunolide.html","C15H20O2","free base","NSC 106404","CC/1=C\\CC\\C(=C\\C2OC(=O)C(=C)C2CC1)C",4.022,2,0,0]
["S1322","Dexamethasone (MK-125)","c2","L6200-03","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1324","Doxazosin Mesylate","d2","L6200-03","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.",547.58,"77883-43-3",{"v":15,"d":"15.00"},27.39,"<1","N/A","http://selleckchem.com/products/Doxazosin-mesylate.html","C23H25N5O5.CH4O3S","Mesylate","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCN(CC3)C(=O)C4COC5=C(O4)C=CC=C5)N.C[S](O)(=O)=O",2.071,7,1,4]
["S1328","Etodolac","e2","L6200-03","in 10mM DMSO","COX","Neuronal Signaling","Etodolac(AY-24236) is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.",287.35,"41340-25-4",{"v":58,"d":"58.00"},201.84,"<1","N/A","http://selleckchem.com/products/Etodolac.html","C17H21NO3","free base","AY-24236","CCC1=CC=CC2=C1[NH]C3=C2CCOC3(CC)CC(O)=O",3.723,2,1,4]
["S1333","Fluoxetine (Lilly 110140) HCl","f2","L6200-03","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.",345.79,"56296-78-7",{"v":69,"d":"69.00"},199.54,{"v":4,"d":"4.00"},11.57,"http://selleckchem.com/products/Fluoxetine-hydrochloride.html","C17H18F3NO.HCl","Hydrochloride","Prozac, Sarafem,LY-110140","Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2",4.415,1,1,7]
["S1334","Flupirtine maleate","g2","L6200-03","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.",420.39,"75507-68-5",{"v":84,"d":"84.00"},199.81,"<1","N/A","http://selleckchem.com/products/Flupirtine-maleate.html","C15H17FN4O2.C4H4O4","Maleate","N/A","CCOC(=O)NC1=C(N)N=C(NCC2=CC=C(F)C=C2)C=C1.OC(=O)\\C=C\\C(O)=O",{"v":2.76,"d":"2.760"},5,3,8]
["S1340","Gatifloxacin","h2","L6200-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Gatifloxacin (AM-1155, CG5501, BMS-206584) is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.",375.39,"112811-59-3",{"v":7,"d":"7.00"},18.65,"<1","N/A","http://selleckchem.com/products/Gatifloxacin.html","C19H22FN3O4","free base","AM-1155, CG5501, BMS-206584","COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CCNC(C)C3)F)C4CC4",-0.909,3,1,4]
["S1342","Genistein (NPI 031L)","a3","L6200-03","in 10mM DMSO","EGFR,Topoisomerase","Protein Tyrosine Kinase","Genistein (NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK)  which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.",270.24,"446-72-0",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Genistein.html","C15H10O5","free base","NPI 031L","OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O",{"v":2.14,"d":"2.140"},2,3,1]
["S1344","Glimepiride","b3","L6200-03","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glimepiride(HOE-490) is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.",490.62,"93479-97-1",{"v":11,"d":"11.00"},22.42,"<1","N/A","http://selleckchem.com/products/Glimepiride.html","C24H34N4O5S","free base","HOE-490","CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCC(C)CC3)C1=O",3.781,5,3,7]
["S1351","Ivermectin (MK-933)","c3","L6200-03","in 10mM DMSO","AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor","Transmembrane Transporters","Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.",875.09,"70288-86-7",{"v":100,"d":"100.00"},114.27,"<1","N/A","http://selleckchem.com/products/Ivermectin.html","C48H74O14","Free Base","MK-933","CCC(C)C1OC2(CCC1C)CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2",4.743,11,2,8]
["S1352","TG100-115","d3","L6200-03","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.",346.34,"677297-51-7",{"v":9,"d":"9.00"},25.99,"<1","N/A","http://selleckchem.com/products/TG100-115.html","C18H14N6O2","free base","N/A","NC1=NC2=NC(=C(N=C2C(=N1)N)C3=CC(=CC=C3)O)C4=CC=CC(=C4)O",2.687,4,4,2]
["S1354","Lansoprazole","e3","L6200-03","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.",369.36,"103577-45-3",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/Lansoprazole.html","C16H14F3N3O2S","free base","A-65006, AG-1749","CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2",3.442,4,1,6]
["S1357","Lidocaine","f3","L6200-03","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.",234.34,"137-58-6",{"v":47,"d":"47.00"},200.56,{"v":9,"d":"9.00"},38.41,"http://selleckchem.com/products/Lidocaine.html","C14H22N2O","Free Base","Alphacaine","CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",2.626,1,1,5]
["S1364","Patupilone (Epothilone B)","g3","L6200-03","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Patupilone (EPO906, Epothilone B) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Phase 2.",507.68,"152044-54-7",{"v":102,"d":"102.00"},200.91,"<1","N/A","http://selleckchem.com/products/Epothilone-B.html","C27H41NO6S","free base","EPO906","CC1CCCC2(C)OC2CC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)\\C(C)=C\\C3=CSC(=N3)C",3.779,5,2,2]
["S1367","Amonafide","h3","L6200-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.",283.33,"69408-81-7",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://selleckchem.com/products/Amonafide.html","C16H17N3O2","free base","NSC308847,AS1413","CN(C)CCN1C(=O)C2=C3C(=CC=C2)C=C(N)C=C3C1=O",1.162,2,1,3]
["S1368","Acitretin","a4","L6200-03","in 10mM DMSO","Retinoid Receptor","Metabolism","Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.",326.43,"55079-83-9",{"v":20,"d":"20.00"},61.27,"<1","N/A","http://selleckchem.com/products/Acitretin.html","C21H26O3","free base","Etretin, RO 10-1670","COC1=CC(=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(=C1C)C)C",5.665,2,0,6]
["S1369","Bafetinib (INNO-406)","b4","L6200-03","in 10mM DMSO","Bcr-Abl","Angiogenesis","Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.",576.62,"859212-16-1",{"v":100,"d":"100.00"},173.42,"<1","N/A","http://selleckchem.com/products/Bafetinib.html","C30H31F3N8O","free base","NS-187","CN(C)C1CCN(C1)CC2=CC=C(C=C2C(F)(F)F)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CN=CN=C5",4.197,5,2,9]
["S1373","Daptomycin (LY146032)","c4","L6200-03","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Bacterial,DNA/RNA Synthesis","DNA Damage/DNA Repair","Daptomycin (Cubicin,LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.",1620.67,"103060-53-3",{"v":100,"d":"100.00"},{"v":61.7,"d":"61.70"},{"v":100,"d":"100.00"},{"v":61.7,"d":"61.70"},"http://selleckchem.com/products/Daptomycin.html","C72H101N17O26","free base","Cubicin,LY146032","CCCCCCCCCC(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC3C(C)OC(=O)C(CC(=O)C4=CC=CC=C4N)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCN)NC(=O)CNC3=O)C(C)CC(O)=O",-7.895,21,18,35]
["S1378","Ruxolitinib (INCB018424)","d4","L6200-03","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",306.37,"941678-49-5",{"v":61,"d":"61.00"},199.11,"<1","N/A","http://selleckchem.com/products/INCB18424.html","C17H18N6","free base","INCB018424","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S1380","Lopinavir (ABT-378)","e4","L6200-03","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.",{"v":628.8,"d":"628.80"},"192725-17-0",{"v":126,"d":"126.00"},200.38,"<1","N/A","http://selleckchem.com/products/Lopinavir.html","C37H48N4O5","free base","ABT-378","CC(C)C(N1CCCNC1=O)C(=O)NC(CC(O)C(CC2=CC=CC=C2)NC(=O)COC3=C(C)C=CC=C3C)CC4=CC=CC=C4",4.926,4,4,15]
["S1386","Nafamostat mesilate (FUT-175)","f4","L6200-03","in 10mM DMSO","Apoptosis related,COVID-19,SARS-CoV,Serine Protease","Proteases","Nafamostat mesilate (Futhan, FUT-175) is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis. Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. Nafamostat Mesilate attenuates inflammation and apoptosis.",539.58,"82956-11-4",{"v":20,"d":"20.00"},37.07,{"v":53,"d":"53.00"},98.22,"http://selleckchem.com/products/Nafamostat-mesylate.html","C19H17N5O2.2CH4O3S","Dimesylate","Futhan, FUT-175","C[S](O)(=O)=O.C[S](O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(N)=N",1.364,2,3,6]
["S1389","Omeprazole","g4","L6200-03","in 10mM DMSO","ATPase,Autophagy,Proton Pump","Transmembrane Transporters","Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.",345.42,"73590-58-6",{"v":69,"d":"69.00"},199.76,"<1","N/A","http://selleckchem.com/products/Omeprazole.html","C17H19N3O3S","free base","N/A","COC1=CC=C2[NH]C(=NC2=C1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.904,5,1,5]
["S1393","Pirarubicin (NSC-333054)","h4","L6200-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Pirarubicin (NSC-333054,THP) is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.",627.64,"72496-41-4",{"v":7,"d":"7.00"},11.15,"<1","N/A","http://selleckchem.com/products/Pirarubicin.html","C32H37NO12","free base","NSC-333054,THP","COC1=CC=CC2=C1C(=O)C3=C(O)C4=C(CC(O)(CC4OC5CC(N)C(OC6CCCCO6)C(C)O5)C(=O)CO)C(=C3C2=O)O",1.091,8,4,7]
["S1396","Resveratrol (SRT501)","a5","L6200-03","in 10mM DMSO","AMPK,Apoptosis related,Autophagy,COX,ERK,IκB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT","Autophagy","Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.",228.24,"501-36-0",{"v":45,"d":"45.00"},197.16,"<1","N/A","http://selleckchem.com/products/Resveratrol.html","C14H12O3","free base","trans-Resveratrol,SRT501","OC1=CC=C(C=C1)\\C=C\\C2=CC(=CC(=C2)O)O",{"v":3.09,"d":"3.090"},0,3,2]
["S1398","Stavudine (d4T)","b5","L6200-03","in 10mM DMSO","Reverse Transcriptase","Microbiology","Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.",224.21,"3056-17-5",{"v":45,"d":"45.00"},{"v":200.7,"d":"200.70"},"<1","N/A","http://selleckchem.com/products/Stavudine.html","C10H12N2O4","free base","BMY-27857, Sanilvudine, NSC 163661,d4T","CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O",-0.515,3,2,2]
["S1400","Tenofovir (GS 1278) Disoproxil Fumarate","c5","L6200-03","in 10mM DMSO","HIV,Reverse Transcriptase","Microbiology","Tenofovir Disoproxil Fumarate (Tenofovir DF,GS-1278 Disoproxil Fumarate) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.",635.51,"202138-50-9",{"v":100,"d":"100.00"},157.35,"<1","N/A","http://selleckchem.com/products/Tenofovir-Disoproxil-Fumarate.html","C19H30N5O10P.C4H4O4","Fumarate","Tenofovir DF,GS-1278 Disoproxil Fumarate","CC(C)OC(=O)OCO[P](=O)(COC(C)C[N]1C=NC2=C1N=CN=C2N)OCOC(=O)OC(C)C.OC(=O)/C=C/C(O)=O",1.729,14,1,19]
["S1401","Tenofovir","d5","L6200-03","in 10mM DMSO","Antiviral,COVID-19,Reverse Transcriptase","Microbiology","Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.",287.21,"147127-20-6",{"v":4,"d":"4.00"},13.93,{"v":2,"d":"2.00"},6.96,"http://selleckchem.com/products/Tenofovir.html","C9H14N5O4P","free base","GS-1278","CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O",-0.772,4,1,5]
["S1403","Tigecycline (GAR-936)","e5","L6200-03","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Bacterial","Microbiology","Tigecycline (Tygacil, GAR-936, WAY-GAR-936, TBG-MINO) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline induces autophagy by downregulating the PI3K-AKT-mTOR pathway.",585.65,"220620-09-7",{"v":100,"d":"100.00"},170.75,{"v":100,"d":"100.00"},170.75,"http://selleckchem.com/products/Tigecycline.html","C29H39N5O8","free base","Tygacil, GAR-936, WAY-GAR-936, TBG-MINO","CN(C)C1C2CC3CC4=C(C(=C(NC(=O)CNC(C)(C)C)C=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O",-0.381,4,6,7]
["S1422","Droxinostat","f5","L6200-03","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.",243.69,"99873-43-5",{"v":49,"d":"49.00"},201.08,"<1","N/A","http://selleckchem.com/products/Droxinostat.html","C11H14ClNO3","free base","NS 41080","CC1=CC(=CC=C1OCCCC(=O)NO)Cl",{"v":2.4,"d":"2.400"},2,1,5]
["S1425","Ranolazine 2HCl","g5","L6200-03","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine 2HCl (RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.",500.46,"95635-56-6",{"v":100,"d":"100.00"},199.82,{"v":100,"d":"100.00"},199.82,"http://selleckchem.com/products/Ranolazine-dihydrochloride.html","C24H33N3O4.2HCl","Dihydrochloride","RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride","Cl.Cl.COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",3.755,3,2,9]
["S1431","Sildenafil Citrate","h5","L6200-03","in 10mM DMSO","PDE","Metabolism","Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.",{"v":666.7,"d":"666.70"},"171599-83-0",{"v":20,"d":"20.00"},{"v":30,"d":"30.00"},"<1","N/A","http://selleckchem.com/products/Sildenafil-citrate.html","C22H30N6O4S.C6H8O7","Citrate","N/A","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4.OC(=O)CC(O)(CC(O)=O)C(O)=O",-2.107,9,1,12]
["S1438","Topiramate","a6","L6200-03","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.",339.36,"97240-79-4",{"v":68,"d":"68.00"},200.38,"<1","N/A","http://selleckchem.com/products/Topiramate.html","C12H21NO8S","free base","MCN 4853, RWJ 17021","CC1(C)OC2COC3(CO[S](N)(=O)=O)OC(C)(C)OC3C2O1",-1.932,6,1,3]
["S1445","Zonisamide","b6","L6200-03","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.",212.23,"68291-97-4",{"v":42,"d":"42.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/Zonisamide.html","C8H8N2O3S","free base","Zonegran,CI-912,AD 810","N[S](=O)(=O)CC1=NOC2=CC=CC=C12",0.411,4,1,2]
["S1451","Aurora A Inhibitor I (TC-S 7010)","c6","L6200-03","in 10mM DMSO","Apoptosis related,Aurora Kinase","Cell Cycle","Aurora A Inhibitor I (TC-S 7010) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.",588.07,"1158838-45-9",{"v":118,"d":"118.00"},200.66,"<1","N/A","http://selleckchem.com/products/Aurora-A-Inhibitor-I.html","C31H31ClFN7O2","free base","N/A","CCN1CCN(CC1)C(=O)CC2=CC=C(NC3=NC(=C(F)C=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)C=C2",5.621,4,3,9]
["S1452","Ispinesib (SB-715992)","d6","L6200-03","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death.",517.06,"336113-53-2",{"v":103,"d":"103.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Ispinesib-mesilate(SB-715992).html","C30H33ClN4O2","free base","CK0238273","CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4",5.259,3,1,9]
["S1454","PHA-680632","e6","L6200-03","in 10mM DMSO","Aurora Kinase","Cell Cycle","PHA-680632 is a potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.",501.62,"398493-79-3",{"v":100,"d":"100.00"},199.35,"<1","N/A","http://selleckchem.com/products/PHA-680632.html","C28H35N7O2","free base","N/A","CCC1=CC=CC(=C1NC(=O)N2CC3=C(C2)C(=N[NH]3)NC(=O)C4=CC=C(C=C4)N5CCN(C)CC5)CC",4.339,3,3,6]
["S1457","Atazanavir (BMS-232632) Sulfate","f6","L6200-03","in 10mM DMSO","HIV Protease","Proteases","Atazanavir Sulfate (BMS-232632-05, Reyataz) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.",802.93,"229975-97-7",{"v":104,"d":"104.00"},129.53,"<1","N/A","http://selleckchem.com/products/Atazanavir.html","C38H52N6O7.H2SO4","Sulfate","BMS-232632-05, Reyataz","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C.O[S](O)(=O)=O",4.083,7,5,18]
["S1458","Neflamapimod (VX-745)","g6","L6200-03","in 10mM DMSO","p38 MAPK","MAPK","Neflamapimod (VX-745) is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.",436.26,"209410-46-8",{"v":15,"d":"15.00"},34.38,"<1","N/A","http://selleckchem.com/products/VX-745.html","C19H9Cl2F2N3OS","free base","N/A","FC1=CC(=C(SC2=NN3C=NC(=O)C(=C3C=C2)C4=C(Cl)C=CC=C4Cl)C=C1)F",5.342,3,0,3]
["S1459","Thiazovivin","h6","L6200-03","in 10mM DMSO","ROCK","Cell Cycle","Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation.",311.36,"1226056-71-8",{"v":15,"d":"15.00"},48.18,"<1","N/A","http://selleckchem.com/products/Thiazovivin.html","C15H13N5OS","free base","N/A","O=C(NCC1=CC=CC=C1)C2=CSC(=N2)NC3=CC=NC=N3",2.357,4,2,5]
["S1462","AZD6482","a7","L6200-03","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.",408.45,"1173900-33-8",{"v":82,"d":"82.00"},200.76,"<1","N/A","http://selleckchem.com/products/azd6482.html","C22H24N4O4","free base","KIN-193","CC(NC1=CC=CC=C1C(O)=O)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C",2.003,4,1,5]
["S1465","Moxifloxacin (BAY12-8039) HCl","b7","L6200-03","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Moxifloxacin (Avelox, Avalox,BAY12-8039 HCl) is a fourth-generation synthetic fluoroquinolone antibacterial agent.",437.89,"186826-86-8",{"v":87,"d":"87.00"},198.68,{"v":60,"d":"60.00"},137.02,"https://www.selleckchem.com/products/Moxifloxacin-hcl.html","C21H24FN3O4.HCl","Hydrochloride","Avelox, Avalox,BAY12-8039 HCl","Cl.COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(=C1N3CC4CCCNC4C3)F)C5CC5",{"v":-0.32,"d":"-0.320"},3,1,4]
["S1467","Doxercalciferol","c7","L6200-03","in 10mM DMSO","Vitamin","Metabolism","Doxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.",412.65,"54573-75-0",{"v":83,"d":"83.00"},201.14,"<1","N/A","http://selleckchem.com/products/Doxercalciferol(Hectorol).html","C28H44O2","free base","1α-hydroxyvitamin D2","CC(C)C(C)/C=C/C(C)C1CCC2C(/CCCC12C)=C/C=C/3CC(O)CC(O)C3=C",6.337,0,2,5]
["S1474","GSK429286A","d7","L6200-03","in 10mM DMSO","ROCK","Cell Cycle","GSK429286A (RHO-15) is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.",432.37,"864082-47-3",{"v":87,"d":"87.00"},201.22,"<1","N/A","http://selleckchem.com/products/GSK429286A.html","C21H16F4N4O2","free base","RHO-15","CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(F)C=C4[NH]N=CC4=C3",3.033,3,3,4]
["S1476","SB525334","e7","L6200-03","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.",343.42,"356559-20-1",{"v":68,"d":"68.00"},198.01,"<1","N/A","http://selleckchem.com/products/SB-525334.html","C21H21N5","free base","N/A","CC1=NC(=CC=C1)C2=C([NH]C(=N2)C(C)(C)C)C3=CC=C4N=CC=NC4=C3",4.305,4,1,3]
["S1480","Lomibuvir (VX-222)","f7","L6200-03","in 10mM DMSO","HCV Protease","Proteases","Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.",445.61,"1026785-59-0",{"v":89,"d":"89.00"},199.73,"<1","N/A","http://selleckchem.com/products/VX-222.html","C25H35NO4S","free base","VCH-222","CC1CCC(CC1)C(=O)N(C2CCC(O)CC2)C3=C(SC(=C3)C#CC(C)(C)C)C(O)=O",6.021,2,1,6]
["S1482","Daclatasvir (BMS-790052)","g7","L6200-03","in 10mM DMSO","HCV Protease","Proteases","Daclatasvir (BMS-790052, EBP883) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.",738.88,"1009119-64-5",{"v":148,"d":"148.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/BMS-790052.html","C40H50N8O6","free base","EBP883","COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C([NH]5)C6CCCN6C(=O)C(NC(=O)OC)C(C)C",5.048,8,4,13]
["S1484","MC1568","h7","L6200-03","in 10mM DMSO","HDAC","Cytoskeletal Signaling","MC1568 is a selective HDAC inhibitor for maize HD1-A with IC50 of 100 nM in a cell-free assay. It is 34-fold more selective for HD1-A than HD1-B.",314.31,"852475-26-4",{"v":13,"d":"13.00"},41.36,"<1","N/A","http://selleckchem.com/products/MC1568.html","C17H15FN2O3","free base","N/A","C[N]1C=C(/C=C/C(=O)C2=CC=CC(=C2)F)C=C1\\C=C\\C(=O)NO",2.981,2,1,5]
["S1485","HMN-214","a8","L6200-03","in 10mM DMSO","PLK","Cell Cycle","HMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.",424.47,"173529-46-9",{"v":12,"d":"12.00"},28.27,"<1","N/A","http://selleckchem.com/products/HMN-214.html","C22H20N2O5S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)N(C(C)=O)C2=C(C=CC=C2)\\C=C\\C3=CC=[N+]([O-])C=C3",2.282,4,0,6]
["S1487","PHA-793887","b8","L6200-03","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1.",361.48,"718630-59-2",{"v":72,"d":"72.00"},199.18,"<1","N/A","http://selleckchem.com/products/PHA-793887.html","C19H31N5O2","free base","N/A","CC(C)CC(=O)NC1=N[NH]C2=C1CN(C(=O)C3CCN(C)CC3)C2(C)C",1.895,3,2,4]
["S1489","PIK-93","c8","L6200-03","in 10mM DMSO","PI4K","PI3K/Akt/mTOR","PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.",389.88,"593960-11-3",{"v":78,"d":"78.00"},200.06,"<1","N/A","http://selleckchem.com/products/PIK-93.html","C14H16ClN3O4S2","free base","N/A","CC(=O)NC1=NC(=C(S1)C2=CC(=C(Cl)C=C2)[S](=O)(=O)NCCO)C",1.076,4,3,6]
["S1490","Ponatinib (AP24534)","d8","L6200-03","in 10mM DMSO","Autophagy,Bcr-Abl,FGFR,PDGFR,Src,VEGFR","Angiogenesis","Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.",532.56,"943319-70-8",{"v":30,"d":"30.00"},56.33,"<1","N/A","http://selleckchem.com/products/AP24534.html","C29H27F3N6O","free base","AP24534","CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F",4.884,3,1,7]
["S1491","Fludarabine (NSC 118218)","e8","L6200-03","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite,STAT","JAK/STAT","Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.",285.23,"21679-14-1",{"v":57,"d":"57.00"},199.84,"<1","N/A","http://selleckchem.com/products/Fludarabine(Fludara).html","C10H12FN5O4","Free Base","FaraA, Fludarabinum, NSC 118218","NC1=NC(=NC2=C1N=C[N]2C3OC(CO)C(O)C3O)F",-1.312,4,4,2]
["S1497","Pralatrexate (NSC 754230)","f8","L6200-03","in 10mM DMSO","Apoptosis related,DHFR","Metabolism","Pralatrexate (NSC 754230) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.",477.47,"146464-95-1",{"v":28,"d":"28.00"},58.64,"<1","N/A","http://selleckchem.com/products/Pralatrexate(Folotyn).html","C23H23N7O5","free base","NSC 754230","NC1=NC(=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)C=NC2=N1)N",{"v":1.94,"d":"1.940"},7,3,10]
["S1515","Pracinostat (SB939)","g8","L6200-03","in 10mM DMSO","Apoptosis related,HDAC","Cytoskeletal Signaling","Pracinostat (SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6. It has no activity against the class III isoenzyme SIRT I. Pracinostat (SB939) induces apoptosis in tumor cells. Phase 2.",358.48,"929016-96-6",{"v":72,"d":"72.00"},200.85,"<1","N/A","http://selleckchem.com/products/SB939.html","C20H30N4O2","free base","N/A","CCCCC1=NC2=CC(=CC=C2[N]1CCN(CC)CC)\\C=C\\C(=O)NO",{"v":3.71,"d":"3.710"},2,1,10]
["S1523","Voxtalisib (XL765) Analogue","h8","L6200-03","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",599.66,"1349796-36-6",{"v":12,"d":"12.00"},20.01,"<1","N/A","http://selleckchem.com/products/XL765(SAR245409).html","C31H29N5O6S","free base","SAR245409","COC1=CC(=CC(=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=C(NC(=O)C5=CC=C(C)C(=C5)OC)C=C4)OC",5.631,8,3,10]
["S1524","AT7519","a9","L6200-03","in 10mM DMSO","Apoptosis related,CDK,GSK-3","Cell Cycle","AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also decrease GSK3β phosphorylation. AT7519 induces apoptosis. Phase 2.",382.24,"844442-38-2",{"v":10,"d":"10.00"},26.16,"<1","N/A","http://selleckchem.com/products/AT7519.html","C16H17Cl2N5O2","Free Base","N/A","ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",1.599,3,4,4]
["S1525","Adavosertib (MK-1775)","b9","L6200-03","in 10mM DMSO","Wee1","Cell Cycle","Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.",{"v":500.6,"d":"500.60"},"955365-80-7",{"v":80,"d":"80.00"},159.81,"N/A","N/A","http://selleckchem.com/products/MK-1775.html","C27H32N8O2","free base","AZD1775","CN1CCN(CC1)C2=CC=C(NC3=NC4=C(C=N3)C(=O)N(CC=C)N4C5=NC(=CC=C5)C(C)(C)O)C=C2",4.158,4,1,7]
["S1526","Quizartinib (AC220)","c9","L6200-03","in 10mM DMSO","Apoptosis related,FLT3,Target Protein Ligand","Angiogenesis","Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.",560.67,"950769-58-1",{"v":33,"d":"33.00"},58.86,"<1","N/A","http://selleckchem.com/products/AC-220.html","C29H32N6O4S","free base","N/A","CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=C[N]4C(=N3)SC5=CC(=CC=C45)OCCN6CCOCC6",5.064,6,2,8]
["S1528","LY2811376","d9","L6200-03","in 10mM DMSO","BACE,Beta Amyloid","Proteases","LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.",320.36,"1194044-20-6",{"v":16,"d":"16.00"},49.94,"<1","N/A","http://selleckchem.com/products/LY2811376.html","C15H14F2N4S","free base","N/A","CC1(CCSC(=N1)N)C2=CC(=C(F)C=C2F)C3=CN=CN=C3",2.478,3,1,2]
["S1529","Hesperadin","e9","L6200-03","in 10mM DMSO","Aurora Kinase","Cell Cycle","Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.",516.65,"422513-13-1",{"v":103,"d":"103.00"},199.36,"<1","N/A","http://selleckchem.com/products/Hesperadin.html","C29H32N4O3S","free base","N/A","CC[S](=O)(=O)NC1=CC=C2NC(=O)C(=C(NC3=CC=C(CN4CCCCC4)C=C3)/C5=CC=CC=C5)/C2=C1",4.071,3,3,8]
["S1532","AZD7762","f9","L6200-03","in 10mM DMSO","Chk","Cell Cycle","AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.",362.42,"860352-01-8",{"v":50,"d":"50.00"},137.96,"<1","N/A","http://selleckchem.com/products/AZD7762.html","C17H19FN4O2S","free base","N/A","NC(=O)NC1=C(SC(=C1)C2=CC(=CC=C2)F)C(=O)NC3CCCNC3",2.009,2,4,4]
["S1538","Telaprevir (VX-950)","g9","L6200-03","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Telaprevir (VX-950, LY-570310, MP-424) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.",679.85,"402957-28-2",{"v":136,"d":"136.00"},200.04,"<1","N/A","http://selleckchem.com/products/Telaprevir(VX-950).html","C36H53N7O6","free base","LY-570310, MP-424,VX-950","CCCC(NC(=O)C1C2CCCC2CN1C(=O)C(NC(=O)C(NC(=O)C3=NC=CN=C3)C4CCCCC4)C(C)(C)C)C(=O)C(=O)NC5CC5",2.685,8,4,14]
["S1540","Saxagliptin (BMS-477118)","h9","L6200-03","in 10mM DMSO","DPP","Proteases","Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",315.41,"361442-04-8",{"v":63,"d":"63.00"},199.74,{"v":63,"d":"63.00"},199.74,"http://selleckchem.com/products/Saxagliptin(Onglyza).html","C18H25N3O2","Free Base","Onglyza,BMS-477118","NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.275,1,1,2]
["S1541","Selisistat (EX 527)","a10","L6200-03","in 10mM DMSO","Sirtuin","Epigenetics","Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.",248.71,"49843-98-3",{"v":49,"d":"49.00"},197.02,"<1","N/A","http://selleckchem.com/products/EX-527.html","C13H13ClN2O","free base","SEN0014196","NC(=O)C1CCCC2=C1[NH]C3=C2C=C(Cl)C=C3",3.149,1,2,1]
["S1547","Febuxostat","b10","L6200-03","in 10mM DMSO","ROS","Immunology & Inflammation","Febuxostat (TMX 67, TEI-6720) is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.",316.37,"144060-53-7",{"v":63,"d":"63.00"},199.13,"<1","N/A","http://selleckchem.com/products/Febuxostat(Uloric).html","C16H16N2O3S","free base","TMX 67, TEI-6720","CC(C)COC1=C(C=C(C=C1)C2=NC(=C(S2)C(O)=O)C)C#N",3.468,3,0,5]
["S1555","AZD8055","c10","L6200-03","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.",465.54,"1009298-09-2",{"v":50,"d":"50.00"},{"v":107.4,"d":"107.40"},"<1","N/A","http://selleckchem.com/products/AZD8055.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=C(C=C2)C(=NC(=N3)N4CCOCC4C)N5CCOCC5C",3.274,6,1,5]
["S1556","PHT-427","d10","L6200-03","in 10mM DMSO","Akt,PDPK1","PI3K/Akt/mTOR","PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.",409.61,"1191951-57-1",{"v":82,"d":"82.00"},200.19,"<1","N/A","http://selleckchem.com/products/PHT-427.html","C20H31N3O2S2","free base","CS-0223","CCCCCCCCCCCCC1=CC=C(C=C1)[S](=O)(=O)NC2=NN=CS2",6.296,4,1,14]
["S1558","AT7867","e10","L6200-03","in 10mM DMSO","Akt,S6 Kinase","PI3K/Akt/mTOR","AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.",337.85,"857531-00-1",{"v":68,"d":"68.00"},201.27,"<1","N/A","http://selleckchem.com/products/AT7867.html","C20H20ClN3","free base","N/A","ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=C[NH]N=C4",{"v":3.85,"d":"3.850"},1,2,3]
["S1570","KU-60019","f10","L6200-03","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.",547.67,"925701-49-1",{"v":18,"d":"18.00"},32.87,"<1","N/A","http://selleckchem.com/products/KU-60019.html","C30H33N3O5S","free base","N/A","CC1CN(CC(C)O1)CC(=O)NC2=CC3=C(SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6)C=C2",3.818,5,1,5]
["S1572","BS-181 HCl","g10","L6200-03","in 10mM DMSO","CDK","Cell Cycle","BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.",416.99,"1397219-81-6",{"v":83,"d":"83.00"},199.05,{"v":3,"d":"3.00"},7.19,"http://selleckchem.com/products/BS-181.html","C22H32N6.HCl","Hydrochloride","N/A","Cl.CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)[N]2N=C1",4.684,2,3,11]
["S1573","Fasudil (HA-1077) HCl","h10","L6200-03","in 10mM DMSO","Autophagy,Calcium Channel,MLCK,PKA,PKC,PKG,Rho,ROCK","Cell Cycle","Fasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.",327.83,"105628-07-7",{"v":5,"d":"5.00"},15.25,{"v":65,"d":"65.00"},198.27,"http://selleckchem.com/products/Fasudil-HCl(HA-1077).html","C14H17N3O2S.HCl","Hydrochloride","AT-877,HA-1077 HCl","Cl.O=[S](=O)(N1CCCNCC1)C2=C3C=CN=CC3=CC=C2",{"v":0.57,"d":"0.570"},3,1,2]
["S1574","Doramapimod (BIRB 796)","a11","L6200-03","in 10mM DMSO","JNK,p38 MAPK,Raf,Src","MAPK","Doramapimod (BIRB 796) is a  pan-p38 MAPK inhibitor with IC50 of  38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2.",527.66,"285983-48-4",{"v":100,"d":"100.00"},189.52,"<1","N/A","http://selleckchem.com/products/BIRB-796-(Doramapimod).html","C31H37N5O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5)C(C)(C)C",5.907,4,2,8]
["S1576","Sulfasalazine (NSC 667219)","b11","L6200-03","in 10mM DMSO","Apoptosis related,Autophagy,COX,Ferroptosis,Immunology & Inflammation related,NF-κB,TGF-beta/Smad","Immunology & Inflammation","Sulfasalazine (NSC 667219, Azulfidine, Salazopyrin, Sulphasalazine) is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. Sulfasalazine is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. Sulfasalazine induces ferroptosis, apoptosis and autophagy.",398.39,"599-79-1",{"v":80,"d":"80.00"},200.81,"<1","N/A","http://selleckchem.com/products/Sulfasalazine(Azulfidine).html","C18H14N4O5S","free base","Azulfidine, Salazopyrin, Sulphasalazine, NSC 667219","OC(=O)C1=C(O)C=CC(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.463,6,2,6]
["S1582","H 89 2HCl","c11","L6200-03","in 10mM DMSO","Autophagy,PKA,PKG,S6 Kinase","PI3K/Akt/mTOR","H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM in a cell-free assay, 10-fold selective for PKA than PKG,500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. H 89 2HCl induces autophagy.",519.28,"130964-39-5",{"v":104,"d":"104.00"},200.28,{"v":6,"d":"6.00"},11.55,"http://selleckchem.com/products/H-89-dihydrochloride.html","C20H20BrN3O2S.2HCl","Dihydrochloride","N/A","Cl.Cl.BrC1=CC=C(/C=C/CNCCN[S](=O)(=O)C2=CC=CC3=C2C=CN=C3)C=C1",3.665,3,2,8]
["S1590","TWS119","d11","L6200-03","in 10mM DMSO","Autophagy,GSK-3","PI3K/Akt/mTOR","TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.",318.33,"601514-19-6",{"v":64,"d":"64.00"},201.05,"<1","N/A","http://selleckchem.com/products/TWS119.html","C18H14N4O2","free base","N/A","NC1=CC(=CC=C1)C2=CC3=C([NH]2)N=CN=C3OC4=CC=CC(=C4)O",3.464,3,3,3]
["S1593","Apixaban (BMS 562247-01)","e11","L6200-03","in 10mM DMSO","Factor Xa","Metabolism","Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.",{"v":459.5,"d":"459.50"},"503612-47-3",{"v":18,"d":"18.00"},39.17,"<1","N/A","http://selleckchem.com/products/Apixaban(BMS-562247-01).html","C25H25N5O4","free base","BMS 562247-01","COC1=CC=C(C=C1)[N]2N=C(C(N)=O)C3=C2C(=O)N(CC3)C4=CC=C(C=C4)N5CCCCC5=O",2.865,5,1,5]
["S1594","Semagacestat (LY450139)","f11","L6200-03","in 10mM DMSO","Beta Amyloid,Notch,Secretase","Proteases","Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.",361.44,"425386-60-3",{"v":72,"d":"72.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/Semagacestat(LY450139).html","C19H27N3O4","free base","N/A","CC(C)C(O)C(=O)NC(C)C(=O)NC1C(=O)N(C)CCC2=C1C=CC=C2",0.632,3,3,5]
["S1620","Darunavir Ethanolate","g11","L6200-03","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Darunavir Ethanolate (TMC-114, UIC 94017) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.",593.73,"635728-49-3",{"v":100,"d":"100.00"},168.43,"<1","N/A","http://selleckchem.com/products/Darunavir-Ethanolate(Prezista).html","C27H37N3O7S.C2H5OH","Ethanolate","TMC-114, UIC 94017","CCO.CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2COC3OCCC23)[S](=O)(=O)C4=CC=C(N)C=C4",2.622,6,4,12]
["S1626","Naproxen Sodium","h11","L6200-03","in 10mM DMSO","COX","Neuronal Signaling","Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.",252.24,"26159-34-2",{"v":3,"d":"3.00"},11.89,{"v":50,"d":"50.00"},198.22,"http://selleckchem.com/products/Naproxen-Sodium(Aleve).html","C14H13NaO3","Sodium Salt","RS-3650","[Na+].COC1=CC=C2C=C(C=CC2=C1)C(C)C([O-])=O",1.375,1,0,3]
["S1627","Nitazoxanide (NSC 697855)","a2","L6200-04","in 10mM DMSO","Autophagy,Influenza Virus,mTOR,Serotonin Transporter","Microbiology","Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulates autophagy and inhibits mTORC1 signaling.",307.28,"55981-09-4",{"v":62,"d":"62.00"},201.77,"<1","N/A","http://selleckchem.com/products/Nitazoxanide(Alinia).html","C12H9N3O5S","free base","NTZ, NSC 697855","CC(=O)OC1=C(C=CC=C1)C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.398,4,1,5]
["S1629","Orlistat (Ro 18-0647)","b2","L6200-04","in 10mM DMSO","Apoptosis related,Fatty Acid Synthase,Lipase","Metabolism","Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.",495.73,"96829-58-2",{"v":99,"d":"99.00"},199.71,"<1","N/A","http://selleckchem.com/products/Orlistat(Alli).html","C29H53NO5","free base","Tetrahydrolipstatin,Ro 18-0647","CCCCCCCCCCCC(CC1OC(=O)C1CCCCCC)OC(=O)C(CC(C)C)NC=O",8.333,5,1,23]
["S1630","Allopurinol","c2","L6200-04","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.",136.11,"315-30-0",{"v":27,"d":"27.00"},198.37,{"v":4,"d":"4.00"},29.39,"http://selleckchem.com/products/Allopurinol(Zyloprim).html","C5H4N4O","Free Base","N/A","O=C1N=CN=C2NNC=C12",-2.125,3,2,0]
["S1631","Allopurinol Sodium","d2","L6200-04","in 10mM DMSO","ROS","Immunology & Inflammation","Allopurinol Sodium  is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.",{"v":159.1,"d":"159.10"},"17795-21-0",{"v":32,"d":"32.00"},201.13,{"v":32,"d":"32.00"},201.13,"http://selleckchem.com/products/Allopurinol-Sodium(Aloprim).html","C5H4N4NaO","Sodium Salt","N/A","[Na+].O=C1NC=NC2=C1C=N[NH]2",-0.681,3,2,0]
["S1638","Ibuprofen (NSC 256857)","e2","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Ibuprofen (NSC 256857, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.",206.28,"15687-27-1",{"v":41,"d":"41.00"},198.76,"<1","N/A","http://selleckchem.com/products/Ibuprofen(Advil).html","C13H18O2","free base","Dolgesic,NSC 256857","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O",3.607,1,0,4]
["S1639","Amprenavir (VX-478)","f2","L6200-04","in 10mM DMSO","HIV Protease","Proteases","Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.",505.63,"161814-49-9",{"v":16,"d":"16.00"},31.64,"<1","N/A","http://selleckchem.com/products/Amprenavir-(Agenerase).html","C25H35N3O6S","free base","141W94, VX-478, KVX-478","CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)[S](=O)(=O)C3=CC=C(N)C=C3",2.429,5,3,12]
["S1645","Ketoprofen","g2","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.",254.28,"22071-15-4",{"v":51,"d":"51.00"},200.57,"<1","N/A","http://selleckchem.com/products/Ketoprofen(Actron).html","C16H14O3","free base","RP-19583","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S1646","Ketorolac","h2","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.",255.27,"74103-06-3",{"v":75,"d":"75.00"},293.81,"<1","N/A","http://selleckchem.com/products/Ketorolac-Tromethamine(Toradol).html","C15H13N1O3","free base","N/A","OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",2.832,2,0,3]
["S1647","Adenosine","a3","L6200-04","in 10mM DMSO","Adenosine Receptor,Nucleoside Analog/Antimetabolite","GPCR & G Protein","Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.",267.24,"58-61-7",{"v":12,"d":"12.00"},{"v":44.9,"d":"44.90"},"<1","N/A","http://selleckchem.com/products/Adenosine(Adenocard).html","C10H13N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-1.881,4,4,2]
["S1652","Monobenzone","b3","L6200-04","in 10mM DMSO","Tyrosinase","Proteases","Monobenzone(Benoquin) is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.",200.23,"103-16-2",{"v":40,"d":"40.00"},199.77,"<1","N/A","http://selleckchem.com/products/Monobenzone(Benoquin).html","C13H12O2","free base","Benoquin","OC1=CC=C(OCC2=CC=CC=C2)C=C1",3.155,1,1,3]
["S1653","Tretinoin (NSC 122758)","c3","L6200-04","in 10mM DMSO","Retinoid Receptor","Metabolism","Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.",{"v":300.4,"d":"300.40"},"302-79-4",{"v":60,"d":"60.00"},199.73,"<1","N/A","http://selleckchem.com/products/Tretinoin(Aberela).html","C20H28O2","free base","Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(C)(C)CCC1",5.551,1,0,5]
["S1654","Phenylbutazone","d3","L6200-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phenylbutazone (Butazolidine) is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.",308.37,"50-33-9",{"v":62,"d":"62.00"},201.06,"<1","N/A","http://selleckchem.com/products/Phenylbutazone(Butazolidin).html","C19H20N2O2","free base","Butazolidine","CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3",3.954,2,0,5]
["S1655","Ezetimibe (SCH-58235)","e3","L6200-04","in 10mM DMSO","LDL","Metabolism","Ezetimibe (SCH-58235) is a potent, selective, cholesterol absorption inhibitor, used to lower cholesterol.",{"v":409.4,"d":"409.40"},"163222-33-1",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/Ezetimibe(Zetia).html","C24H21F2NO3","free base","SCH-58235","OC(CCC1C(N(C1=O)C2=CC=C(F)C=C2)C3=CC=C(O)C=C3)C4=CC=C(F)C=C4",4.633,1,2,6]
["S1657","Enalaprilat Dihydrate","f3","L6200-04","in 10mM DMSO","RAAS","Endocrinology & Hormones","Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.",{"v":348.4,"d":"348.40"},"84680-54-6",{"v":70,"d":"70.00"},200.92,"<1","N/A","http://selleckchem.com/products/Enalaprilat.html","C18H24N2O5.2H2O","Dihydrate","MK-422 Dihydrate","O.O.CC(NC(CCC1=CC=CC=C1)C(O)=O)C(=O)N2CCCC2C(O)=O",{"v":-1.53,"d":"-1.530"},3,1,8]
["S1662","Isradipine","g3","L6200-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Isradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.",371.39,"75695-93-1",{"v":74,"d":"74.00"},199.25,"<1","N/A","http://selleckchem.com/products/Isradipine(Dynacirc).html","C19H21N3O5","free base","PN 200-110","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC3=NON=C23)C(=O)OC(C)C)C",2.168,7,1,6]
["S1677","Chloramphenicol","h3","L6200-04","in 10mM DMSO","Antibiotics for Plant Cell Culture,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.",323.13,"56-75-7",{"v":65,"d":"65.00"},201.16,"<1","N/A","http://selleckchem.com/products/Chloramphenicol(Chloromycetin).html","C11H12Cl2N2O5","free base","Chloromycetin","OCC(NC(=O)C(Cl)Cl)C(O)C1=CC=C(C=C1)[N+]([O-])=O",1.025,1,3,6]
["S1679","Flurbiprofen","a4","L6200-04","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).",244.26,"5104-49-4",{"v":49,"d":"49.00"},200.61,"<1","N/A","http://selleckchem.com/products/Flurbiprofen(Ansaid).html","C15H13FO2","free base","N/A","CC(C(O)=O)C1=CC(=C(C=C1)C2=CC=CC=C2)F",{"v":3.68,"d":"3.680"},1,0,3]
["S1681","Mesalamine (5-ASA)","b4","L6200-04","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK","NF-κB","Mesalamine (5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.",153.14,"89-57-6",{"v":31,"d":"31.00"},202.43,"<1","N/A","http://selleckchem.com/products/Mesalamine(Lialda).html","C7H7NO3","free base","5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa","NC1=CC=C(O)C(=C1)C(O)=O",0.471,1,2,1]
["S1692","Busulfan (NSC-750)","c4","L6200-04","in 10mM DMSO","Apoptosis related,DNA alkylator","DNA Damage/DNA Repair","Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.",{"v":246.3,"d":"246.30"},"55-98-1",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/Busulfan(Busulfex).html","C6H14O6S2","free base","NSC-750","C[S](=O)(=O)OCCCCO[S](C)(=O)=O",-0.289,2,0,7]
["S1693","Carbamazepine","d4","L6200-04","in 10mM DMSO","Autophagy,Sodium Channel","Transmembrane Transporters","Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.",236.27,"298-46-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/Carbamazepine(Carbatrol).html","C15H12N2O","free base","NSC 169864","NC(=O)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3",2.679,1,1,0]
["S1696","Hydrocortisone (NSC 10483)","e4","L6200-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.",362.46,"50-23-7",{"v":73,"d":"73.00"},{"v":201.4,"d":"201.40"},"<1","N/A","http://selleckchem.com/products/Hydrocortisone.html","C21H30O5","free base","Cortisol","CC12CCC(=O)C=C1CCC3C4CCC(O)(C(=O)CO)C4(C)CC(O)C23",1.283,2,2,2]
["S1703","Divalproex Sodium","f4","L6200-04","in 10mM DMSO","HDAC","Epigenetics","Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.",310.41,"76584-70-8",{"v":62,"d":"62.00"},199.74,{"v":62,"d":"62.00"},199.74,"http://selleckchem.com/products/Divalproex-sodium.html","C8H16O2.C8H15O2.Na","Sodium Salt","N/A","[Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O",4.025,1,0,10]
["S1712","Deferasirox (ICL-670)","g4","L6200-04","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17)","Proteases","Deferasirox (ICL-670, CGP-72670) is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.",373.36,"201530-41-8",{"v":74,"d":"74.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/Deferasirox(Exjade).html","C21H15N3O4","free base","CGP-72670, ICL-670","OC(=O)C1=CC=C(C=C1)[N]2N=C(N=C2C3=CC=CC=C3O)C4=CC=CC=C4O",4.063,3,2,4]
["S1713","Piroxicam","h4","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Piroxicam (CP 16171) is a non-selective COX inhibitor, used in the treatment of rheumatoid and osteoarthritis.",331.35,"36322-90-4",{"v":66,"d":"66.00"},199.19,"<1","N/A","http://selleckchem.com/products/Piroxicam(Feldene).html","C15H13N3O4S","free base","CP 16171","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.501,4,2,2]
["S1714","Gemcitabine (LY-188011)","a5","L6200-04","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.",{"v":263.2,"d":"263.20"},"95058-81-4",{"v":52,"d":"52.00"},197.57,{"v":52,"d":"52.00"},197.57,"http://selleckchem.com/products/Gemcitabine(Gemzar).html","C9H11F2N3O4","Free Base","LY-188011, NSC 613327","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.394,3,3,2]
["S1716","Glyburide (Glibenclamide)","b5","L6200-04","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.",{"v":494,"d":"494.00"},"10238-21-8",{"v":99,"d":"99.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/Glyburide(Diabeta).html","C23H28ClN3O5S","free base","Glibenclamide","COC1=C(C=C(Cl)C=C1)C(=O)NCCC2=CC=C(C=C2)[S](=O)(=O)NC(=O)NC3CCCCC3",{"v":4.14,"d":"4.140"},5,3,8]
["S1723","Indomethacin (NSC-77541)","c5","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Indomethacin (NSC-77541, Indometacin) is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.",357.79,"53-86-1",{"v":72,"d":"72.00"},201.24,"<1","N/A","http://selleckchem.com/products/Indomethacin(Indocid).html","C19H16ClNO4","free base","Indometacin,NSC-77541","COC1=CC=C2[N](C(=C(CC(O)=O)C2=C1)C)C(=O)C3=CC=C(Cl)C=C3",4.235,3,0,4]
["S1729","Gemfibrozil","d5","L6200-04","in 10mM DMSO","PPAR","Metabolism","Gemfibrozil (CI-719) is an activator of peroxisome proliferator-activated receptor-alpha (PPARα), used for the treatment of hypercholesterolemia and hypertriglyceridemia.",250.33,"25812-30-0",{"v":50,"d":"50.00"},199.74,"<1","N/A","http://selleckchem.com/products/Gemfibrozil(Lopid).html","C15H22O3","free base","CI-719","CC1=CC(=C(C)C=C1)OCCCC(C)(C)C(O)=O",4.172,2,0,6]
["S1734","Meloxicam","e5","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.",{"v":351.4,"d":"351.40"},"71125-38-7",{"v":30,"d":"30.00"},85.37,"<1","N/A","http://selleckchem.com/products/Meloxicam(Mobic).html","C14H13N3O4S2","free base","N/A","CN1C(=C(O)C2=C(C=CC=C2)[S]1(=O)=O)C(=O)NC3=NC=C(C)S3",0.255,4,2,2]
["S1736","Methocarbamol","f5","L6200-04","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.",241.24,"532-03-6",{"v":48,"d":"48.00"},198.97,{"v":2,"d":"2.00"},8.29,"http://selleckchem.com/products/Methocarbamol(Robaxin).html","C11H15NO5","free base","AHR 85","COC1=C(OCC(O)COC(N)=O)C=CC=C1",0.916,4,2,7]
["S1738","Telmisartan","g5","L6200-04","in 10mM DMSO","Angiotensin Receptor","GPCR & G Protein","Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.",514.62,"144701-48-4",{"v":13,"d":"13.00"},25.26,"<1","N/A","http://selleckchem.com/products/Telmisartan(Micardis).html","C33H30N4O2","free base","BIBR 277","CCCC1=NC2=C(C=C(C=C2C)C3=NC4=C(C=CC=C4)[N]3C)[N]1CC5=CC=C(C=C5)C6=CC=CC=C6C(O)=O",7.799,3,0,7]
["S1739","Thiabendazole","h5","L6200-04","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property, used as an anthelmintic and fungicide agent. It is a potent inhibitor of  cytochrome P450 1A2 (CYP1A2).",201.25,"148-79-8",{"v":40,"d":"40.00"},198.76,"<1","N/A","http://selleckchem.com/products/Thiabendazole.html","C10H7N3S","free base","N/A","[NH]1C2=C(C=CC=C2)N=C1C3=CSC=N3",2.154,2,1,1]
["S1744","Nicotinic Acid","a6","L6200-04","in 10mM DMSO","Vitamin","Metabolism","Nicotinic Acid is a water-soluble vitamin belonging to the vitamin B family.",123.11,"59-67-6",{"v":25,"d":"25.00"},203.07,{"v":2,"d":"2.00"},16.25,"http://selleckchem.com/products/Niacin(Nicotinic-acid).html","C6H5NO2","free base","N/A","OC(=O)C1=CC=CN=C1",0.309,2,0,1]
["S1747","Nimodipine","b6","L6200-04","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.",418.44,"66085-59-4",{"v":84,"d":"84.00"},200.75,"<1","N/A","http://selleckchem.com/products/Nimodipine(Nimotop).html","C21H26N2O7","free base","BAY E 9736","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C",2.361,5,1,10]
["S1748","Nisoldipine","c6","L6200-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.",388.41,"63675-72-9",{"v":77,"d":"77.00"},198.24,"<1","N/A","http://selleckchem.com/products/Nisoldipine(Sular).html","C20H24N2O6","free base","BAY K 5552","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC=C2[N+]([O-])=O)C(=O)OCC(C)C)C",2.958,4,1,8]
["S1756","Enoxacin","d6","L6200-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Enoxacin (AT-2266, CI919, Pd107779, NSC 629661) is an oral broad-spectrum fluoroquinolone antibacterial agent by inhibiting bacterial DNA gyrase and topoisomerase IV, used to treat a wide variety of infections.",320.32,"74011-58-8",{"v":32,"d":"32.00"},{"v":99.9,"d":"99.90"},"<1","N/A","http://selleckchem.com/products/Enoxacin(Penetrex).html","C15H17FN4O3","free base","AT-2266, CI919, Pd107779, NSC 629661","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(N=C12)N3CCNCC3)F",-1.483,3,1,3]
["S1759","Pitavastatin (NK-104) calcium","e6","L6200-04","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,HMG-CoA Reductase,Mitophagy","Metabolism","Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.",880.98,"147526-32-7",{"v":51,"d":"51.00"},57.89,"<1","N/A","http://selleckchem.com/products/Pitavastatin-calcium(Livalo).html","C50H46CaF2N2O8","Calcium salt","NK-104, P-872441, itavastatin, nisvastatin","[Ca++].OC(CC(O)C=CC1=C(C2=CC=C(F)C=C2)C3=CC=CC=C3N=C1C4CC4)CC([O-])=O.OC(CC(O)C=CC5=C(C6=CC=C(F)C=C6)C7=CC=CC=C7N=C5C8CC8)CC([O-])=O",{"v":4.96,"d":"4.960"},2,4,16]
["S1760","Rifapentine","f6","L6200-04","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rifapentine (MDL473) is an antibiotic, which inhibits DNA-dependent RNA polymerase activity, used to treat tuberculosis.",877.03,"61379-65-5",{"v":100,"d":"100.00"},114.02,"<1","N/A","http://selleckchem.com/products/Rifapentine(Priftin).html","C47H64N4O12","free base","MDL473","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(CC5)C6CCCC6",4.664,8,6,6]
["S1761","Suprofen","g6","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Suprofen(TN-762) is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.",260.31,"40828-46-4",{"v":52,"d":"52.00"},199.76,"<1","N/A","http://selleckchem.com/products/Suprofen(Profenal).html","C14H12O3S","free base","TN-762","CC(C(O)=O)C1=CC=C(C=C1)C(=O)C2=CC=CS2",3.314,2,0,4]
["S1762","Pyrazinamide","h6","L6200-04","in 10mM DMSO","Bacterial","Microbiology","Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.",123.11,"98-96-4",{"v":25,"d":"25.00"},203.07,{"v":12,"d":"12.00"},97.47,"http://selleckchem.com/products/Pyrazinamide(Pyrazinoic-acid-amide).html","C5H5N3O","free base","Pyrazinoic Acid Amide","NC(=O)C1=NC=CN=C1",-1.041,3,1,1]
["S1764","Rifampin (NSC-113926)","a7","L6200-04","in 10mM DMSO","Antibiotics for Plant Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Rifampin (NSC-113926, Rimactane, Rifampicin) is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.",822.94,"13292-46-1",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Rifampin(Rifadin).html","C43H58N4O12","free base","Rimactane, Rifampicin,NSC-113926","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(O)C(=C(NC(=O)\\C(=C\\C=C\\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C(=C4C(=C3C)O)O)\\C=N\\N5CCN(C)CC5",3.262,8,6,5]
["S1773","Oxytetracycline (Terramycin)","b7","L6200-04","in 10mM DMSO","Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Others","Oxytetracycline(Terramycin) is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.",460.43,"79-57-2",{"v":92,"d":"92.00"},199.81,"<1","N/A","http://selleckchem.com/products/Oxytetracycline(Terramycin).html","C22H24N2O9","free base","Terramycin","CN(C)C1C2C(O)C3C(=C(O)C4=C(C=CC=C4O)C3(C)O)C(=O)C2(O)C(=O)C(=C1O)C(N)=O",-1.904,3,5,2]
["S1774","Thioguanine (NSC 752)","c7","L6200-04","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1775","Thiotepa","d7","L6200-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.",189.22,"52-24-4",{"v":100,"d":"100.00"},528.49,{"v":100,"d":"100.00"},528.49,"http://selleckchem.com/products/thiotepa-thioplex.html","C6H12N3PS","free base","Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide","S=[P](N1CC1)(N2CC2)N3CC3",-0.762,0,0,3]
["S1778","Trifluridine (NSC 75520)","e7","L6200-04","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.",{"v":296.2,"d":"296.20"},"70-00-8",{"v":59,"d":"59.00"},199.19,{"v":59,"d":"59.00"},199.19,"http://selleckchem.com/products/Trifluridine(Viroptic).html","C10H11F3N2O5","free base","NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT","OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F",-0.782,3,3,3]
["S1782","Azacitidine (5-Azacytidine)","f7","L6200-04","in 10mM DMSO","Autophagy,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.",{"v":244.2,"d":"244.20"},"320-67-2",{"v":48,"d":"48.00"},196.56,"<1","N/A","http://selleckchem.com/products/Azacitidine(Vidaza).html","C8H12N4O5","free base","5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine","NC1=NC(=O)N(C=N1)C2OC(CO)C(O)C2O",-2.505,4,4,2]
["S1784","Vidarabine","g7","L6200-04","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.",267.24,"5536-17-4",{"v":53,"d":"53.00"},198.32,{"v":3,"d":"3.00"},11.23,"http://selleckchem.com/products/Vidarabine(Vira-A).html","C10H13N5O4","free base","N/A","NC1=C2N=C[N](C3OC(CO)C(O)C3O)C2=NC=N1",-1.881,4,4,2]
["S1786","Verteporfin (CL 318952)","h7","L6200-04","in 10mM DMSO","Apoptosis related,Autophagy,TEAD,VDA,YAP","Angiogenesis","Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.  It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.",718.79,"129497-78-5",{"v":100,"d":"100.00"},139.12,"<1","N/A","http://selleckchem.com/products/Verteporfin(Visudyne).html","C41H42N4O8","free base","CL 318952, Visudyne","COC(=O)CCC1=C(C)C2=CC3=NC(=CC4=C(C)C(=C([NH]4)C=C5N=C(C=C1[NH]2)C(=C5C)CCC(O)=O)C=C)C6=CC=C(C(C(=O)OC)C36C)C(=O)OC",7.789,9,2,12]
["S1787","Teniposide","a8","L6200-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Teniposide (NSC 122819, VM-26) is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).",656.65,"29767-20-2",{"v":40,"d":"40.00"},60.92,"<1","N/A","http://selleckchem.com/products/Teniposide(Vumon).html","C32H32O13S","free base","NSC 122819, VM-26","COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(OC4OC5COC(OC5C(O)C4O)C6=CC=CS6)C7=CC8=C(OCO8)C=C27",2.516,10,3,6]
["S1790","Rifaximin","b8","L6200-04","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rifaximin is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.",785.88,"80621-81-4",{"v":47,"d":"47.00"},59.81,"<1","N/A","http://selleckchem.com/products/Rifaximin(Xifaxan).html","C43H51N3O11","free base","N/A","COC1\\C=C\\OC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=C(NC(=O)\\C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C)C5=C4N=C6C=C(C)C=C[N]56)O",4.805,8,5,3]
["S1792","Simvastatin (MK 733)","c8","L6200-04","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,HMG-CoA Reductase,Mitophagy","Metabolism","Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.",418.57,"79902-63-9",{"v":83,"d":"83.00"},198.29,"<1","N/A","http://selleckchem.com/products/Simvastatin(Zocor).html","C25H38O5","free base","MK-0733, MK 733","CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",4.634,4,1,7]
["S1794","Fenofibrate (NSC-281319)","d8","L6200-04","in 10mM DMSO","Autophagy,P450 (e.g. CYP17),PPAR","Metabolism","Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.",360.83,"49562-28-9",{"v":72,"d":"72.00"},199.54,"<1","N/A","http://selleckchem.com/products/Fenofibrate(Tricor).html","C20H21ClO4","free base","NSC-281319","CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2",5.111,4,0,7]
["S1801","Ranitidine Hydrochloride","e8","L6200-04","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ranitidine (AH19065) is a histamine H2-receptor antagonist, used to treat stomach or intestinal ulcers.",350.86,"66357-59-3",{"v":70,"d":"70.00"},199.51,{"v":70,"d":"70.00"},199.51,"http://selleckchem.com/products/Ranitidine-hydrochloride(Zantac).html","C13H22N4O3S.HCl","Hydrochloride","AH19065","Cl.CNC(/NCCSCC1=CC=C(CN(C)C)O1)=C\\[N+]([O-])=O",1.421,1,2,10]
["S1802","AICAR (Acadesine)","f8","L6200-04","in 10mM DMSO","AMPK,Mitophagy","PI3K/Akt/mTOR","AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.",258.23,"2627-69-2",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Acadesine.html","C9H14N4O5","free base","NSC105823, AICA Riboside","NC(=O)C1=C(N)[N](C=N1)C2OC(CO)C(O)C2O",-2.913,3,5,3]
["S1805","Acetylcholine Chloride","g8","L6200-04","in 10mM DMSO","AChR","Neuronal Signaling","The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.",181.66,"60-31-1",{"v":36,"d":"36.00"},198.17,{"v":36,"d":"36.00"},198.17,"http://www.selleck.cn/products/Acetylcholine-chloride.html","C7H16NO2.Cl","Chloride","ACh chloride","[Cl-].CC(=O)OCC[N+](C)(C)C",-3.869,2,0,4]
["S1808","Nifedipine (BAY-a-1040)","h8","L6200-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.",346.33,"21829-25-4",{"v":69,"d":"69.00"},199.23,"<1","N/A","http://selleckchem.com/products/Nifedipine(Adalat).html","C17H18N2O6","free base","BAY-a-1040","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC)C",1.766,4,1,6]
["S1820","Clofibrate","a9","L6200-04","in 10mM DMSO","Others","Others","Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.",{"v":242.7,"d":"242.70"},"637-07-0",{"v":7,"d":"7.00"},28.84,"<1","N/A","http://www.selleck.cn/products/Clofibrate(Atromid-S).html","C12H15ClO3","Free Base","N/A","CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1",3.329,3,0,5]
["S1825","Erdosteine","b9","L6200-04","in 10mM DMSO","NF-κB","NF-κB","Erdosteine (KW-9144,RV 144) is a mucolytic which is used in treatment of excessive viscous mucus. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation.",249.31,"84611-23-4",{"v":50,"d":"50.00"},200.55,"<1","N/A","http://selleckchem.com/products/erdosteine.html","C8H11NO4S2","free base","KW-9144,RV 144","OC(=O)CSCC(=O)NC1CCSC1=O",-0.382,3,1,5]
["S1830","Oxfendazole","c9","L6200-04","in 10mM DMSO","Parasite","Microbiology","Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.",315.35,"53716-50-0",{"v":10,"d":"10.00"},31.71,"<1","N/A","http://selleckchem.com/products/oxfendazole.html","C15H13N3O3S","free base","RS-8858,Fenbendazole sulfoxide","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)[S](=O)C3=CC=CC=C3",2.657,4,2,4]
["S1831","Carvedilol","d9","L6200-04","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.",406.47,"72956-09-3",{"v":81,"d":"81.00"},199.28,"<1","N/A","http://selleckchem.com/products/carvedilol.html","C24H26N2O4","free base","BM-14190, SKF 105517","COC1=CC=CC=C1OCCNCC(O)COC2=C3C(=CC=C2)[NH]C4=C3C=CC=C4",4.014,3,3,10]
["S1835","Azithromycin (CP-62993)","e9","L6200-04","in 10mM DMSO","Antibiotics,Antibiotics for Mammalian Cell Culture,Autophagy,Bacterial,COVID-19","Autophagy","Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.",748.98,"83905-01-5",{"v":100,"d":"100.00"},133.51,"<1","N/A","http://selleckchem.com/products/azithromycin-zithromax.html","C38H72N2O12","Free Base","XZ-450,CP-62993","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)CN(C)C(C)C(O)C1(C)O",2.078,7,3,7]
["S1840","Lomustine","f9","L6200-04","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging the DNA and stops cells from dividing.",{"v":233.7,"d":"233.70"},"13010-47-4",{"v":46,"d":"46.00"},196.83,"<1","N/A","http://selleckchem.com/products/Lomustine(CeeNU).html","C9H16ClN3O2","free base","NSC79037, Gleostine, CeeNU, CCNU","ClCCN(N=O)C(=O)NC1CCCCC1",2.394,2,1,4]
["S1847","Clemastine (HS-592) fumarate","g9","L6200-04","in 10mM DMSO","Autophagy,Histamine Receptor,mTOR","Neuronal Signaling","Clemastine Fumarate (HS-592, Meclastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Clemastine stimulates autophagy via mTOR pathway.",459.96,"14976-57-9",{"v":35,"d":"35.00"},76.09,"<1","N/A","http://selleckchem.com/products/Clemastine-Fumarate.html","C21H26ClNO.C4H4O4","Fumarate","HS-592 fumarate, Meclastine fumarate","CN1CCCC1CCOC(C)(C2=CC=CC=C2)C3=CC=C(Cl)C=C3.OC(=O)\\C=C\\C(O)=O",{"v":1.81,"d":"1.810"},3,0,8]
["S1848","Curcumin","h9","L6200-04","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S1849","Daidzein","a10","L6200-04","in 10mM DMSO","PPAR","Metabolism","Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.",254.24,"486-66-8",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Daidzein.html","C15H10O4","free base","N/A","OC1=CC=C(C=C1)C2=COC3=CC(=CC=C3C2=O)O",2.382,2,2,1]
["S1878","Ganciclovir (BW 759)","b10","L6200-04","in 10mM DMSO","CMV","Microbiology","Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.",255.23,"82410-32-0",{"v":27,"d":"27.00"},105.79,"<1","N/A","http://selleckchem.com/products/ganciclovir.html","C9H13N5O4","free base","RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine","NC1=NC2=C(N=C[N]2COC(CO)CO)C(=O)N1",-1.934,4,4,5]
["S1885","Felodipine","c10","L6200-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Felodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.",384.25,"72509-76-3",{"v":77,"d":"77.00"},200.39,"<1","N/A","http://selleckchem.com/products/Felodipine(Plendil).html","C18H19Cl2NO4","free base","CGH-869","CCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",3.549,4,1,6]
["S1896","Hydroxyurea (NSC-32065)","d10","L6200-04","in 10mM DMSO","Apoptosis related,Autophagy,DNA/RNA Synthesis,HIV","DNA Damage/DNA Repair","Hydroxyurea (NSC-32065, NCI-C04831, Hydroxycarbamide) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.",76.05,"127-07-1",{"v":15,"d":"15.00"},197.24,{"v":15,"d":"15.00"},197.24,"http://selleckchem.com/products/Hydroxyurea(Cytodrox).html","CH4N2O2","free base","NCI-C04831, Hydroxycarbamide,NSC-32065","NC(=O)NO",{"v":-1.03,"d":"-1.030"},1,2,0]
["S1897","Potassium Iodide","e10","L6200-04","in 10mM DMSO","Others","Others","Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.",{"v":166,"d":"166.00"},"7681-11-0",{"v":33,"d":"33.00"},{"v":198.8,"d":"198.80"},{"v":33,"d":"33.00"},{"v":198.8,"d":"198.80"},"http://selleckchem.com/products/Potassium-iodide.html","K+I-","Inorganic salt","N/A","[K+].[I-]",-3.113,0,0,0]
["S1899","Nicotinamide (NSC 13128)","f10","L6200-04","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide (Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.",122.12,"98-92-0",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/Nicotinamide(Niacinamide).html","C6H6N2O","free base","Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452,NSC 13128","NC(=O)C1=CC=CN=C1",-0.319,2,1,1]
["S1903","Diclofenac Sodium","g10","L6200-04","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac Sodium (GP 45840) is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.",318.13,"15307-79-6",{"v":64,"d":"64.00"},201.18,{"v":14,"d":"14.00"},44.01,"http://selleckchem.com/products/Diclofenac-sodium.html","C14H10Cl2NNaO2","Sodium Salt","GP 45840","[Na+].[O-]C(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",2.899,0,1,4]
["S1905","Amlodipine","h10","L6200-04","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",408.88,"88150-42-9",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Amlodipine(Norvasc).html","C20H25ClN2O5","free base","UK-48340","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C",1.576,5,2,10]
["S1907","Metronidazole","a11","L6200-04","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis","DNA Damage/DNA Repair","Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.",171.15,"443-48-1",{"v":34,"d":"34.00"},198.66,"<1","N/A","http://selleckchem.com/products/Metronidazole(Flagyl).html","C6H9N3O3","free base","N/A","CC1=NC=C([N]1CCO)[N+]([O-])=O",-0.337,1,1,3]
["S1909","Fluvastatin (XU-62-320) Sodium","b11","L6200-04","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Fluvastatin Sodium (Vastin,XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.",433.45,"93957-55-2",{"v":87,"d":"87.00"},200.72,{"v":1,"d":"1.00"},2.31,"http://selleckchem.com/products/Fluvastatin-Sodium(Lescol).html","C24H25FNNaO4","Sodium","Vastin,XU-62-320","[Na+].CC(C)[N]1C2=C(C=CC=C2)C(=C1\\C=C\\C(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3",{"v":2.77,"d":"2.770"},0,2,8]
["S1914","Pregnenolone","c11","L6200-04","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Pregnenolone(3β-Hydroxy-5-pregnen-20-one) is an endogenous steroid hormone, used in the treatment of fatigue, Alzheimer’s disease, trauma and injuries.",316.48,"145-13-1",{"v":22,"d":"22.00"},69.51,"<1","N/A","http://selleckchem.com/products/pregnenolone.html","C21H32O2","free base","3β-Hydroxy-5-pregnen-20-one","CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C",3.624,1,1,1]
["S1933","Triamcinolone","d11","L6200-04","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.",394.43,"124-94-7",{"v":78,"d":"78.00"},197.75,"<1","N/A","http://selleckchem.com/products/Triamcinolone(Aristocort).html","C21H27FO6","free base","N/A","CC12CC(O)C3(F)C(CCC4=CC(=O)C=CC34C)C1CC(O)C2(O)C(=O)CO",0.422,2,3,2]
["S1937","Isoniazid","e11","L6200-04","in 10mM DMSO","Fatty Acid Synthase","Metabolism","Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.",137.14,"54-85-3",{"v":27,"d":"27.00"},196.88,{"v":27,"d":"27.00"},196.88,"http://selleckchem.com/products/Isoniazid(Tubizid).html","C6H7N3O","free base","N/A","NNC(=O)C1=CC=NC=C1",-0.811,2,2,1]
["S1940","Levofloxacin","f11","L6200-04","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.",361.37,"100986-85-4",{"v":24,"d":"24.00"},66.41,{"v":11,"d":"11.00"},30.44,"http://selleckchem.com/products/levofloxacin-levaquin.html","C18H20FN3O4","Free Base","Fluoroquinolone","CC1COC2=C(N3CCN(C)CC3)C(=CC4=C2N1C=C(C(O)=O)C4=O)F",-1.374,3,0,2]
["S1949","Menadione (NSC 4170)","g11","L6200-04","in 10mM DMSO","CDK,DNA/RNA Synthesis,phosphatase","Metabolism","Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.",172.18,"58-27-5",{"v":34,"d":"34.00"},197.47,"<1","N/A","http://selleckchem.com/products/Menadione.html","C11H8O2","free base","Vitamin K3,NSC 4170","CC1=CC(=O)C2=CC=CC=C2C1=O",2.204,2,0,0]
["S1950","Metformin HCl","h11","L6200-04","in 10mM DMSO","Autophagy,Carbohydrate Metabolism,JNK,Mitophagy,p38 MAPK","Metabolism","Metformin HCl (1,1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.",165.62,"1115-70-4",{"v":33,"d":"33.00"},199.25,{"v":33,"d":"33.00"},199.25,"http://selleckchem.com/products/Metformin-hydrochloride(Glucophage).html","C4H11N5.HCl","Hydrochloride","1,1-Dimethylbiguanide HCl","Cl.CN(C)C(=N)NC(N)=N",{"v":-0.36,"d":"-0.360"},0,2,3]
["S1952","Methoxsalen","a2","L6200-05","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Methoxsalen (Xanthotoxin, NCI-C55903) is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant, used in the diagnosis and treatment of psoriasis; A CYP2A5/6 inhibitor.",216.19,"298-81-7",{"v":43,"d":"43.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Methoxsalen(Oxsoralen).html","C12H8O4","free base","Xanthotoxin, NCI-C55903","COC1=C2OC=CC2=CC3=C1OC(=O)C=C3",2.187,4,0,1]
["S1959","Tolfenamic Acid","b2","L6200-05","in 10mM DMSO","COX","Neuronal Signaling","Tolfenamic Acid(Clotam) is a COX-2 inhibitor with IC50 of 0.2 μM.",{"v":261.7,"d":"261.70"},"13710-19-5",{"v":52,"d":"52.00"},{"v":198.7,"d":"198.70"},"<1","N/A","http://selleckchem.com/products/tolfenamic-acid.html","C14H12ClNO2","free base","Clotam","CC1=C(Cl)C=CC=C1NC2=C(C=CC=C2)C(O)=O",{"v":4.16,"d":"4.160"},1,1,3]
["S1960","Pranoprofen","c2","L6200-05","in 10mM DMSO","COX,PGES","Neuronal Signaling","Pranoprofen (Pyranoprofen,Pranopulin) is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.",255.27,"52549-17-4",{"v":51,"d":"51.00"},199.79,"<1","N/A","http://selleckchem.com/products/pranoprofen.html","C15H13NO3","free base","Pyranoprofen,Pranopulin","CC(C(O)=O)C1=CC2=C(OC3=NC=CC=C3C2)C=C1",{"v":3.05,"d":"3.050"},3,0,2]
["S1972","Tamoxifen (ICI 46474) Citrate","d2","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,Estrogen/progestogen Receptor,HSP (HSP90)","Endocrinology & Hormones","Tamoxifen Citrate (Istubal,ICI 46474 Citrate) is a selective estrogen receptor modulator (SERM). Tamoxifen Citrate is also a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen induces apoptosis and autophagy.",563.64,"54965-24-1",{"v":100,"d":"100.00"},177.42,"<1","N/A","http://selleckchem.com/products/Tamoxifen-Citrate(Nolvadex).html","C26H29NO.C6H8O7","Citrate","Istubal,ICI 46474 Citrate","CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3.OC(=O)CC(O)(CC(O)=O)C(O)=O",1.966,4,0,13]
["S1973","Cyclocytidine HCl","e2","L6200-05","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.",261.66,"10212-25-6",{"v":10,"d":"10.00"},38.22,{"v":44,"d":"44.00"},168.16,"http://selleckchem.com/products/cyclocytidine-hcl.html","C9H12ClN3O4","Hydrochloride","NSC 145668 HCl","Cl.OCC1OC2C(OC3=NC(=N)C=CN23)C1O",-1.395,3,2,1]
["S1979","Amiodarone (NSC 85442) HCl","f2","L6200-05","in 10mM DMSO","Autophagy,Potassium Channel","Transmembrane Transporters","Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.",681.77,"19774-82-4",{"v":23,"d":"23.00"},33.74,"<1","N/A","http://selleckchem.com/products/amiodarone-hcl.html","C25H29I2NO3.HCl","Hydrochloride","Amiodar,Amiodarone hydrochloride,Nexterone","Cl.CCCCC1=C(C(=O)C2=CC(=C(OCCN(CC)CC)C(=C2)I)I)C3=C(O1)C=CC=C3",{"v":7.62,"d":"7.620"},3,0,11]
["S1983","Adenine HCl","g2","L6200-05","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Adenine HCl(6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.",171.59,"2922-28-3",{"v":8,"d":"8.00"},46.62,{"v":4,"d":"4.00"},23.31,"http://selleckchem.com/products/adenine-hydrochloride.html","C5H5N5.HCl","Hydrochloride","6-Aminopurine hydrochloride","Cl.NC1=NC=NC2=C1N=C[NH]2",{"v":-0.06,"d":"-0.060"},3,2,0]
["S1988","Propylthiouracil","h2","L6200-05","in 10mM DMSO","Peroxidases","Metabolism","Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.",170.23,"51-52-5",{"v":34,"d":"34.00"},199.73,"<1","N/A","http://selleckchem.com/products/Propylthiouracil.html","C7H10N2OS","free base","NSC 6498, NSC 70461","CCCC1=CC(=O)NC(=S)N1",1.575,1,2,2]
["S1990","Capsaicin(Vanilloid)","a3","L6200-05","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Capsaicin (Qutenza, Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.",305.41,"404-86-4",{"v":61,"d":"61.00"},199.73,"<1","N/A","http://selleckchem.com/products/capsaicin.html","C18H27NO3","free base","Qutenza, Vanilloid","COC1=C(O)C=CC(=C1)CNC(=O)CCCC\\C=C\\C(C)C",{"v":3.91,"d":"3.910"},2,2,9]
["S1994","Lacidipine","b3","L6200-05","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.",455.54,"103890-78-4",{"v":91,"d":"91.00"},199.76,"<1","N/A","http://selleckchem.com/products/lacidipine-lacipil-motens.html","C26H33NO6","free base","GX-1048, GR-43659X, SN-305","CCOC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)\\C=C\\C(=O)OC(C)(C)C)C(=O)OCC)C",3.824,6,1,11]
["S2006","Pyrimethamine","c3","L6200-05","in 10mM DMSO","DHFR","Metabolism","Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.",248.71,"58-14-0",{"v":10,"d":"10.00"},40.21,"<1","N/A","http://selleckchem.com/products/Pyrimethamine.html","C12H13ClN4","free base","RP 4753","CCC1=NC(=NC(=C1C2=CC=C(Cl)C=C2)N)N",{"v":2.75,"d":"2.750"},2,2,2]
["S2007","Sulindac","d3","L6200-05","in 10mM DMSO","COX","Neuronal Signaling","Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions.",356.41,"38194-50-2",{"v":71,"d":"71.00"},199.21,"<1","N/A","http://selleckchem.com/products/Sulindac(Clinoril).html","C20H17FO3S","free base","MK-231","CC1=C(CC(O)=O)C2=C(C=CC(=C2)F)\\C1=C/C3=CC=C(C=C3)[S](C)=O",3.639,2,0,4]
["S2011","Pramipexole 2HCl Monohydrate","e3","L6200-05","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.",302.26,"191217-81-9",{"v":41,"d":"41.00"},135.64,{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"http://selleckchem.com/products/Pramipexole-dihydrochloride-monohydrate.html","C10H17N3S.2HCl.H2O","Dihydrochloride monohydrate","N/A","O.Cl.Cl.CCCNC1CCC2=C(C1)SC(=N2)N",{"v":1.94,"d":"1.940"},1,2,3]
["S2012","PCI-34051","f3","L6200-05","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.",296.32,"950762-95-5",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://selleckchem.com/products/pci-34051.html","C17H16N2O3","free base","N/A","COC1=CC=C(C[N]2C=CC3=C2C=C(C=C3)C(=O)NO)C=C1",2.911,2,1,4]
["S2014","BMS-265246","g3","L6200-05","in 10mM DMSO","CDK","Cell Cycle","BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.",345.34,"582315-72-8",{"v":20,"d":"20.00"},57.91,"<1","N/A","http://selleckchem.com/products/bms-265246.html","C18H17F2N3O2","free base","N/A","CCCCOC1=C2C=N[NH]C2=NC=C1C(=O)C3=C(F)C=C(C)C=C3F",4.135,4,1,6]
["S2018","ENMD-2076 L-(+)-Tartaric acid","h3","L6200-05","in 10mM DMSO","Aurora Kinase,FLT3,VEGFR","Angiogenesis","ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.",525.56,"1291074-87-7",{"v":100,"d":"100.00"},190.27,"<1","N/A","http://selleckchem.com/products/enmd-2076-l-tartaric-acid.html","C25H31N7O6","free base","N/A","CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)\\C=C\\C4=CC=CC=C4.OC(C(O)C(O)=O)C(O)=O",-0.683,5,4,8]
["S2029","Uridine","a4","L6200-05","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Uridine (NSC 20256,β-Uridine, Uridin) is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.",{"v":244.2,"d":"244.20"},"58-96-8",{"v":49,"d":"49.00"},200.66,{"v":49,"d":"49.00"},200.66,"http://selleckchem.com/products/uridine.html","C9H12N2O6","free base","NSC 20256,β-Uridine, Uridin","OCC1OC(C(O)C1O)N2C=CC(=O)NC2=O",-2.451,3,4,2]
["S2032","Rebamipide","b4","L6200-05","in 10mM DMSO","CCK receptor","GPCR & G Protein","Rebamipide (OPC-12759,Proamipide) is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.",370.79,"90098-04-7",{"v":74,"d":"74.00"},199.57,"<1","N/A","http://selleckchem.com/products/rebamipide.html","C19H15ClN2O4","free base","OPC-12759,Proamipide","OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C3=CC=C(Cl)C=C3",2.606,3,2,5]
["S2040","Nimesulide","c4","L6200-05","in 10mM DMSO","COX","Neuronal Signaling","Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.",308.31,"51803-78-2",{"v":62,"d":"62.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://selleckchem.com/products/Nimesulide.html","C13H12N2O5S","free base","N/A","C[S](=O)(=O)NC1=C(OC2=CC=CC=C2)C=C(C=C1)[N+]([O-])=O",2.195,3,1,5]
["S2043","Memantine HCl","d4","L6200-05","in 10mM DMSO","NMDAR","Neuronal Signaling","Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.",215.76,"41100-52-1",{"v":43,"d":"43.00"},{"v":199.3,"d":"199.30"},{"v":30,"d":"30.00"},139.04,"http://selleckchem.com/products/memantine-hydrochloride-namenda.html","C12H21N.HCl","Hydrochloride","N/A","Cl.CC12C[CH]3CC(C)([CH2]1)C[C](N)(C3)C2",2.289,0,1,0]
["S2045","Doxifluridine","e4","L6200-05","in 10mM DMSO","Phosphorylase","Metabolism","Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).",246.19,"3094-09-5",{"v":49,"d":"49.00"},199.03,{"v":49,"d":"49.00"},199.03,"http://selleckchem.com/products/doxifluridine.html","C9H11FN2O5","free base","5'-DFUR, AMC 0101","CC1OC(C(O)C1O)N2C=C(F)C(=O)NC2=O",-1.653,3,3,1]
["S2046","Pioglitazone HCl","f4","L6200-05","in 10mM DMSO","Ferroptosis,P450 (e.g. CYP17),PPAR","Metabolism","Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.",{"v":392.9,"d":"392.90"},"112529-15-4",{"v":79,"d":"79.00"},201.07,"<1","N/A","http://selleckchem.com/products/pioglitazone-hydrochloride-actos.html","C19H20N2O3S.HCl","Hydrochloride","AD-4833, U-72107E","Cl.CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",4.289,4,1,7]
["S2053","Cytidine","g4","L6200-05","in 10mM DMSO","Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.",243.22,"65-46-3",{"v":49,"d":"49.00"},201.46,{"v":49,"d":"49.00"},201.46,"http://selleckchem.com/products/cytidine.html","C9H13N3O5","free base","N/A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S2057","Cyclophosphamide (NSC-26271) Monohydrate","h4","L6200-05","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.",{"v":279.1,"d":"279.10"},"6055-19-2",{"v":55,"d":"55.00"},197.06,{"v":7,"d":"7.00"},25.08,"http://selleckchem.com/products/cyclophosphamide-monohydrate.html","C7H15Cl2N2O2P.H2O","Monohydrate","Cytoxan Monohydrate","O.ClCCN(CCCl)[P]1(=O)NCCCO1",-0.063,2,1,5]
["S2060","Bromhexine HCl","a5","L6200-05","in 10mM DMSO","Others","Others","Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.",412.59,"611-75-6",{"v":6,"d":"6.00"},14.54,"<1","N/A","http://selleckchem.com/products/bromhexine-hydrochloride.html","C14H20Br2N2.HCl","HCl","N/A","Cl.CN(CC1=CC(=CC(=C1N)Br)Br)C2CCCCC2",4.894,0,1,3]
["S2062","Tiopronin","b5","L6200-05","in 10mM DMSO","ROS","Immunology & Inflammation","Tiopronin is an antioxidant agent, used for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.",163.19,"1953-02-2",{"v":32,"d":"32.00"},196.09,{"v":32,"d":"32.00"},196.09,"http://selleckchem.com/products/tiopronin-thiola.html","C5H9NO3S","free base","N/A","CC(S)C(=O)NCC(O)=O",-0.362,2,1,3]
["S2064","Balofloxacin","c5","L6200-05","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Balofloxacin (Q-35,Q-roxin) is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.",389.42,"127294-70-6",{"v":5,"d":"5.00"},12.84,"<1","N/A","http://selleckchem.com/products/balofloxacin.html","C20H24FN3O4","free base","Q-35,Q-roxin","CNC1CCCN(C1)C2=C(OC)C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O",-0.615,3,1,5]
["S2077","Atorvastatin Calcium","d5","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,HMG-CoA Reductase","Metabolism","Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.",1155.34,"134523-03-8",{"v":100,"d":"100.00"},86.55,"<1","N/A","http://selleckchem.com/products/atorvastatin-calcium-lipitor.html","2(C33H34FN2O5).Ca","Calcium","N/A","[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C([N]1CCC(O)CC(O)CC([O-])=O)C3=CC=C(F)C=C3)C4=CC=CC=C4.CC(C)C5=C(C(=O)NC6=CC=CC=C6)C(=C([N]5CCC(O)CC(O)CC([O-])=O)C7=CC=C(F)C=C7)C8=CC=CC=C8",8.163,2,6,24]
["S2098","Bexarotene (LGD1069)","e5","L6200-05","in 10mM DMSO","Retinoid Receptor","Metabolism","Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.",{"v":348,"d":"348.00"},"153559-49-0",{"v":8,"d":"8.00"},22.99,"<1","N/A","http://selleckchem.com/products/bexarotene.html","C24H28O2","free base","Targretin","CC1=CC2=C(C=C1C(=C)C3=CC=C(C=C3)C(O)=O)C(C)(C)CCC2(C)C",6.405,1,0,3]
["S2101","Gabexate Mesylate","f5","L6200-05","in 10mM DMSO","Serine Protease","Proteases","Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.",417.48,"56974-61-9",{"v":83,"d":"83.00"},198.81,{"v":12,"d":"12.00"},28.74,"http://selleckchem.com/products/gabexate-mesylate.html","C16H23N3O4.CH4O3S","Mesylate","FOY","CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1.C[S](O)(=O)=O",1.774,4,2,12]
["S2102","Rasagiline Mesylate","g5","L6200-05","in 10mM DMSO","MAO","Metabolism","Rasagiline Mesylate (TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.",267.34,"161735-79-1",{"v":53,"d":"53.00"},198.25,{"v":53,"d":"53.00"},198.25,"http://selleckchem.com/products/rasagiline-mesylate.html","C12H13N.CH4O3S","Mesylate","TVP-1012,(R)-AGN1135 mesylate,TVP1012 mesylate","C[S](O)(=O)=O.C#CCNC1CCC2=CC=CC=C12",2.705,0,1,2]
["S2108","Flunixin Meglumin","h5","L6200-05","in 10mM DMSO","COX","Neuronal Signaling","Flunixin Meglumin(Banamine) is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.",491.46,"42461-84-7",{"v":98,"d":"98.00"},199.41,{"v":98,"d":"98.00"},199.41,"http://selleckchem.com/products/flunixin-meglumin.html","C14H11F3N2O2.C7H17NO5","Meglumin","Banamine","CNCC(O)C(O)C(O)C(O)CO.CC1=C(C=CC=C1NC2=NC=CC=C2C(O)=O)C(F)(F)F",-1.676,2,7,10]
["S2111","Lapatinib (GW-572016)","a6","L6200-05","in 10mM DMSO","Autophagy,EGFR,Ferroptosis,HER2","Protein Tyrosine Kinase","Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.",581.06,"231277-92-2",{"v":100,"d":"100.00"},{"v":172.1,"d":"172.10"},"<1","N/A","http://selleckchem.com/products/lapatinib.html","C29H26ClFN4O4S","free base","GSK572016, GW2016","C[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(=C5)F)C(=C4)Cl)C3=C2",6.041,6,2,11]
["S2113","Cisatracurium Besylate","b6","L6200-05","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Cisatracurium Besylate(51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.",1243.48,"96946-42-8",{"v":249,"d":"249.00"},200.24,{"v":47,"d":"47.00"},{"v":37.8,"d":"37.80"},"http://selleckchem.com/products/cisatracurium-besylate-nimbex.html","C53H72N2O12.2C6H5O3S","Besylate","51W89","COC1=CC=C(CC2C3=CC(=C(OC)C=C3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCC5=CC(=C(OC)C=C5C4CC6=CC=C(OC)C(=C6)OC)OC)OC)C=C1OC.[O-][S](=O)(=O)C7=CC=CC=C7.[O-][S](=O)(=O)C8=CC=CC=C8",3.646,12,0,28]
["S2114","Dronedarone HCl","c6","L6200-05","in 10mM DMSO","Calcium Channel,Potassium Channel,Sodium Channel","Transmembrane Transporters","Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).",593.22,"141625-93-6",{"v":80,"d":"80.00"},134.86,"<1","N/A","http://selleckchem.com/products/dronedarone-hcl-multaq.html","C31H44N2O5S.HCl","HCl","SR33589","Cl.CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=CC=C(N[S](C)(=O)=O)C=C23",7.397,5,1,18]
["S2131","Roflumilast (B9302-107)","d6","L6200-05","in 10mM DMSO","PDE","Metabolism","Roflumilast (APTA 2217, B9302-107, BY 217, BYK 20869) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay.",403.21,"162401-32-3",{"v":81,"d":"81.00"},200.89,"<1","N/A","http://selleckchem.com/products/Roflumilast(Daxas).html","C17H14Cl2F2N2O3","free base","APTA 2217, B9302-107, BY 217, BYK 20869","FC(F)OC1=CC=C(C=C1OCC2CC2)C(=O)NC3=C(Cl)C=NC=C3Cl",4.402,4,1,7]
["S2151","Sonidegib (NVP-LDE225)","e6","L6200-05","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.",{"v":485.5,"d":"485.50"},"956697-53-3",{"v":97,"d":"97.00"},199.79,"<1","N/A","http://selleckchem.com/products/LDE225(NVP-LDE225).html","C26H26F3N3O3","free base","Erismodegib","CC1CN(CC(C)O1)C2=CC=C(NC(=O)C3=C(C)C(=CC=C3)C4=CC=C(OC(F)(F)F)C=C4)C=N2",6.732,4,1,6]
["S2156","LY2886721","f6","L6200-05","in 10mM DMSO","BACE","Neuronal Signaling","LY2886721 is a BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.",390.41,"1262036-50-9",{"v":9,"d":"9.00"},23.05,"<1","N/A","http://selleckchem.com/products/LY-2886721.html","C18H16F2N4O2S","free base","N/A","NC1=NC2(COCC2CS1)C3=CC(=CC=C3F)NC(=O)C4=NC=C(F)C=C4",2.134,4,2,3]
["S2158","KW-2449","g6","L6200-05","in 10mM DMSO","Aurora Kinase,Bcr-Abl,FLT3","Angiogenesis","KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.",{"v":332.4,"d":"332.40"},"1000669-72-6",{"v":67,"d":"67.00"},201.56,"<1","N/A","http://selleckchem.com/products/KW-2449.html","C20H20N4O","free base","N/A","O=C(N1CCNCC1)C2=CC=C(C=C2)/C=C/C3=N[NH]C4=C3C=CC=C4",2.723,2,2,3]
["S2161","RAF265 (CHIR-265)","h6","L6200-05","in 10mM DMSO","Apoptosis related,Raf,VEGFR","MAPK","RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.",518.41,"927880-90-8",{"v":100,"d":"100.00"},{"v":192.9,"d":"192.90"},"<1","N/A","http://selleckchem.com/products/RAF265(CHIR-265).html","C24H16F6N6O","free base","N/A","C[N]1C(=NC2=C1C=CC(=C2)OC3=CC=NC(=C3)C4=NC=C([NH]4)C(F)(F)F)NC5=CC=C(C=C5)C(F)(F)F",6.469,4,2,7]
["S2162","AZD1480","a7","L6200-05","in 10mM DMSO","JAK","JAK/STAT","AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.",348.77,"935666-88-9",{"v":70,"d":"70.00"},200.71,"<1","N/A","http://www.selleck.cn/products/AZD1480.html","C14H14ClFN8","free base","N/A","CC(NC1=NC=C(Cl)C(=N1)NC2=N[NH]C(=C2)C)C3=NC=C(F)C=N3",2.645,5,3,5]
["S2163","PF-4708671","b7","L6200-05","in 10mM DMSO","Autophagy,S6 Kinase","PI3K/Akt/mTOR","PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.",390.41,"1255517-76-0",{"v":30,"d":"30.00"},76.84,"<1","N/A","http://selleckchem.com/products/pf-4708671.html","C19H21F3N6","free base","N/A","CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C([NH]3)C=CC(=C4)C(F)(F)F",3.886,3,1,5]
["S2169","Rosuvastatin (ZD4522) calcium","c7","L6200-05","in 10mM DMSO","COVID-19,HMG-CoA Reductase","Metabolism","Rosuvastatin Calcium (ZD4522 calcium) is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.",500.57,"147098-20-2",{"v":100,"d":"100.00"},199.77,"<1","N/A","http://selleckchem.com/products/Rosuvastatin-calcium(Crestor).html","C22H28FN3O6S.1/2Ca","Calcium salt","ZD4522 calcium","[Ca++].CC(C)C1=C(\\C=C\\C(O)CC(O)CC([O-])=O)C(=NC(=N1)N(C)[S](C)(=O)=O)C2=CC=C(F)C=C2.CC(C)C3=C(\\C=C\\C(O)CC(O)CC([O-])=O)C(=NC(=N3)N(C)[S](C)(=O)=O)C4=CC=C(F)C=C4",1.906,8,4,20]
["S2170","Givinostat (ITF2357)","d7","L6200-05","in 10mM DMSO","HDAC","Cytoskeletal Signaling","Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.",475.97,"732302-99-7",{"v":95,"d":"95.00"},199.59,"<1","N/A","http://selleckchem.com/products/ITF2357(Givinostat).html","C24H27N3O4.HCl.H2O","Chloride","N/A","O.Cl.CCN(CC)CC1=CC2=C(C=C1)C=C(COC(=O)NC3=CC=C(C=C3)C(=O)NO)C=C2",4.046,3,2,9]
["S2178","AG-14361","e7","L6200-05","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.",320.39,"328543-09-5",{"v":12,"d":"12.00"},37.45,"<1","N/A","http://selleckchem.com/products/AG14361.html","C19H20N4O","free base","N/A","CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3[N]2CCNC4=O",2.576,2,1,3]
["S2179","Gandotinib (LY2784544)","f7","L6200-05","in 10mM DMSO","JAK","JAK/STAT","Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.",469.94,"1229236-86-5",{"v":94,"d":"94.00"},200.03,"<1","N/A","http://selleckchem.com/products/LY2784544.html","C23H25ClFN7O","free base","N/A","CC1=N[NH]C(=C1)NC2=N[N]3C(=C(C)N=C3C(=C2)CN4CCOCC4)CC5=CC=C(Cl)C=C5F",3.938,4,2,6]
["S2180","Ixazomib (MLN2238)","g7","L6200-05","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.",361.03,"1072833-77-2",{"v":72,"d":"72.00"},199.43,"<1","N/A","http://selleckchem.com/products/MLN-2238.html","C14H19BCl2N2O4","Free Base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B(O)O",3.344,2,2,7]
["S2181","Ixazomib Citrate (MLN9708) Analogue","h7","L6200-05","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.",517.12,"1201902-80-8",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://selleckchem.com/products/MLN9708.html","C20H23BCl2N2O9","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)CC(CC(O)=O)(O2)C(O)=O",3.497,7,2,10]
["S2182","SB743921 HCl","a8","L6200-05","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. Phase 1/2.",553.52,"940929-33-9",{"v":111,"d":"111.00"},200.53,{"v":22,"d":"22.00"},39.75,"http://selleckchem.com/products/SB-743921.html","C31H33N2O3.HCl","Hydrochloride","N/A","Cl.CC(C)C(N(CCCN)C(=O)C1=CC=C(C)C=C1)C2=C(CC3=CC=CC=C3)C(=O)C4=C(O2)C=C(Cl)C=C4",6.536,3,1,9]
["S2186","SB505124","b8","L6200-05","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.",{"v":335.4,"d":"335.40"},"694433-59-5",{"v":67,"d":"67.00"},199.76,"<1","N/A","http://selleckchem.com/products/sb-505124.html","C20H21N3O2","free base","N/A","CC1=CC=CC(=N1)C2=C(N=C([NH]2)C(C)(C)C)C3=CC4=C(OCO4)C=C3",4.609,4,1,3]
["S2193","GSK461364","c8","L6200-05","in 10mM DMSO","PLK","Cell Cycle","GSK461364 (GSK461364A) inhibits purified Plk1 with Ki of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3.",{"v":543.6,"d":"543.60"},"929095-18-1",{"v":10,"d":"10.00"},{"v":18.4,"d":"18.40"},"<1","N/A","http://selleckchem.com/products/GSK461364.html","C27H28F3N5O2S","free base","GSK461364A","CC(OC1=C(SC(=C1)[N]2C=NC3=C2C=C(CN4CCN(C)CC4)C=C3)C(N)=O)C5=CC=CC=C5C(F)(F)F",5.125,3,1,8]
["S2195","Lexibulin (CYT997)","d8","L6200-05","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Lexibulin (CYT997, SRI-32007) is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 2.",434.53,"917111-44-5",{"v":86,"d":"86.00"},197.91,"<1","N/A","http://selleckchem.com/products/CYT997.html","C24H30N6O2","free base","SRI-32007","CCCC(NC1=C(C)C=NC(=N1)C2=CC(=C(NC(=O)NCC)C=C2)OC)C3=CC=CN=C3",3.744,5,3,9]
["S2197","A-966492","e8","L6200-05","in 10mM DMSO","PARP","DNA Damage/DNA Repair","A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.",324.35,"934162-61-5",{"v":64,"d":"64.00"},197.32,"<1","N/A","http://selleckchem.com/products/A-966492.html","C18H17FN4O","free base","N/A","NC(=O)C1=C2[NH]C(=NC2=CC=C1)C3=CC=C(C=C3F)C4CCCN4",2.505,2,3,3]
["S2198","SGI-1776 free base","f8","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,FLT3,Haspin Kinase,Pim","JAK/STAT","SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.",405.42,"1025065-69-3",{"v":81,"d":"81.00"},199.79,"<1","N/A","http://selleckchem.com/products/SGI-1776.html","C20H22F3N5O","free base","N/A","CN1CCC(CC1)CNC2=N[N]3C(=NC=C3C4=CC=CC(=C4)OC(F)(F)F)C=C2",5.206,3,1,6]
["S2199","Aliskiren Hemifumarate","g8","L6200-05","in 10mM DMSO","RAAS","Endocrinology & Hormones","Aliskiren hemifumarate(CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate) is a direct renin inhibitor with IC50 of 1.5 nM.",609.83,"173334-58-2",{"v":100,"d":"100.00"},163.98,{"v":100,"d":"100.00"},163.98,"http://selleckchem.com/products/Aliskiren-hemifumarate.html","C30H53N3O6.1/2C4H4O4","fumarate salt","CGP 60536 hemifumarate, CGP60536B hemifumarate, SPP 100 hemifumarate","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.COCCCOC2=C(OC)C=CC(=C2)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C.OC(=O)\\C=C\\C(O)=O",1.735,12,8,40]
["S2207","PIK-293","h8","L6200-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively.",397.43,"900185-01-5",{"v":80,"d":"80.00"},201.29,"<1","N/A","http://selleckchem.com/products/PIK-293.html","C22H19N7O","free base","N/A","CC1=C(C=CC=C1)N2C(=NC3=C(C(=CC=C3)C)C2=O)C[N]4N=CC5=C4N=CN=C5N",3.162,5,1,3]
["S2214","AZ 960","a9","L6200-05","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.",354.36,"905586-69-8",{"v":71,"d":"71.00"},200.36,"<1","N/A","http://selleckchem.com/products/AZ-960.html","C18H16F2N6","free base","N/A","CC(NC1=NC(=C(F)C=C1C#N)NC2=N[NH]C(=C2)C)C3=CC=C(F)C=C3",4.495,2,3,5]
["S2215","DAPT (GSI-IX)","b9","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,Beta Amyloid,Secretase","Proteases","DAPT (GSI-IX, LY-374973) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.",432.46,"208255-80-5",{"v":86,"d":"86.00"},198.86,"<1","N/A","http://selleckchem.com/products/DAPT-GSI-IX.html","C23H26F2N2O4","free base","LY-374973","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC(C(=O)OC(C)(C)C)C2=CC=CC=C2",3.385,4,2,9]
["S2217","Irinotecan (CPT-11) HCl Trihydrate","c9","L6200-05","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Irinotecan (CPT-11) prevents DNA from unwinding by inhibition of topoisomerase 1.",677.18,"136572-09-3",{"v":100,"d":"100.00"},147.67,{"v":1,"d":"1.00"},1.48,"http://selleckchem.com/products/Irinotecan-Hcl-Trihydrate-Campto.html","C33H38N4O6.HCl.3H2O","HCl & trihydrat","CPT-11 HCl Trihydrate","O.O.O.Cl.CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=CC=C(OC(=O)N6CCC(CC6)N7CCCCC7)C=C15)C(O)(CC)C(=O)OC4",3.446,6,0,5]
["S2218","Torkinib (PP242)","d9","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,mTOR","PI3K/Akt/mTOR","Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242) induces mitophagy and apoptosis.",308.34,"1092351-67-1",{"v":61,"d":"61.00"},197.83,"<1","N/A","http://selleckchem.com/products/PP242.html","C16H16N6O","free base","N/A","CC(C)[N]1N=C(C2=CC3=C([NH]2)C=CC(=C3)O)C4=C(N)N=CN=C14",2.908,3,3,2]
["S2219","Momelotinib (CYT387)","e9","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,JAK","JAK/STAT","Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.",414.46,"1056634-68-4",{"v":74,"d":"74.00"},178.55,"<1","N/A","http://selleckchem.com/products/Cyt387.html","C23H22N6O2","free base","LM-1149 , CYT11387","O=C(NCC#N)C1=CC=C(C=C1)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4",2.857,4,2,6]
["S2224","UK 383367","f9","L6200-05","in 10mM DMSO","Procollagen C Proteinase","Metabolism","UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.",324.38,"348622-88-8",{"v":65,"d":"65.00"},200.38,"<1","N/A","http://selleckchem.com/products/UK-383367.html","C15H24N4O4","free base","N/A","NC(=O)C1=NOC(=N1)C(CCCC2CCCCC2)CC(=O)NO",1.731,5,2,8]
["S2225","TAME","g9","L6200-05","in 10mM DMSO","APC,E3 Ligase","Cell Cycle","Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.",342.41,"901-47-3",{"v":69,"d":"69.00"},201.51,{"v":69,"d":"69.00"},201.51,"http://selleckchem.com/products/TAME.html","C14H22N4O4S","free base","N/A","COC(=O)C(CCCNC(N)=N)N[S](=O)(=O)C1=CC=C(C)C=C1",0.749,4,3,10]
["S2226","Idelalisib","h9","L6200-05","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.",415.42,"870281-82-6",{"v":83,"d":"83.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/CAL-101.html","C22H18FN7O","free base","CAL-101, GS-1101","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=NC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)F",3.624,5,2,5]
["S2227","PIK-294","a10","L6200-05","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.",489.53,"900185-02-6",{"v":98,"d":"98.00"},200.19,"<1","N/A","http://selleckchem.com/products/PIK-294.html","C28H23N7O2","free base","N/A","CC1=C(C=CC=C1)N2C(=O)C3=C(C=CC=C3C)N=C2C[N]4N=C(C5=CC(=CC=C5)O)C6=C(N)N=CN=C46",4.867,5,2,4]
["S2228","Belnacasan (VX-765)","b10","L6200-05","in 10mM DMSO","Caspase","Apoptosis","Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay. Phase 2.",{"v":509,"d":"509.00"},"273404-37-8",{"v":100,"d":"100.00"},196.46,"<1","N/A","http://selleckchem.com/products/VX-765.html","C24H33ClN4O6","free base","N/A","CCOC1OC(=O)CC1NC(=O)C2CCCN2C(=O)C(NC(=O)C3=CC(=C(N)C=C3)Cl)C(C)(C)C",1.698,6,3,8]
["S2230","Galunisertib (LY2157299)","c10","L6200-05","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Galunisertib (LY2157299) is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay. Phase 2/3.",369.42,"700874-72-2",{"v":74,"d":"74.00"},200.31,"<1","N/A","http://selleckchem.com/products/ly2157299.html","C22H19N5O","free base","N/A","CC1=CC=CC(=N1)C2=N[N]3CCCC3=C2C4=CC=NC5=C4C=C(C=C5)C(N)=O",3.095,4,1,3]
["S2235","Volasertib (BI 6727)","d10","L6200-05","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.",618.81,"755038-65-4",{"v":20,"d":"20.00"},32.32,"<1","N/A","http://selleckchem.com/products/BI6727-Volasertib.html","C34H50N8O3","free base","N/A","CCC1N(C(C)C)C2=C(C=NC(=N2)NC3=CC=C(C=C3OC)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)N(C)C1=O",4.838,5,2,10]
["S2238","Palomid 529 (P529)","e10","L6200-05","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.",406.43,"914913-88-5",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/Palomid-529-P529.html","C24H22O6","free base","SG 00529","COC1=CC=C(COC2=C(OC)C=C3C(=C2)OC(=O)C4=C3C=CC(=C4)C(C)O)C=C1",4.257,5,1,6]
["S2243","Degrasyn (WP1130)","f10","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,DUB","Angiogenesis","Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.",384.27,"856243-80-6",{"v":77,"d":"77.00"},200.38,"<1","N/A","http://selleckchem.com/products/WP1130.html","C19H18BrN3O","free base","N/A","CCCC(NC(=O)/C(=C/C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",4.546,2,1,6]
["S2244","AR-42","g10","L6200-05","in 10mM DMSO","HDAC","Epigenetics","AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.",312.36,"935881-37-1",{"v":63,"d":"63.00"},201.69,"<1","N/A","http://selleckchem.com/products/AR-42-HDAC-42.html","C18H20N2O3","free base","HDAC-42","CC(C)C(C(=O)NC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",2.834,2,2,5]
["S2246","Abiraterone Acetate (CB7630)","h10","L6200-05","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Metabolism","Abiraterone Acetate (CB7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.",391.55,"154229-18-2",{"v":20,"d":"20.00"},51.08,"<1","N/A","http://www.selleck.cn/products/Abiraterone-Acetate-CB7630.html","C26H33NO2","Acetate","CB7630, CB-7630","CC(=O)OC1CCC2(C)C3CCC4(C)C(CC=C4C5=CC=CN=C5)C3CC=C2C1",4.602,3,0,3]
["S2247","Buparlisib (BKM120)","a11","L6200-05","in 10mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.",410.39,"944396-07-0",{"v":82,"d":"82.00"},199.81,"<1","N/A","http://selleckchem.com/products/BKM-120.html","C18H21F3N6O2","free base","NVP-BKM120","NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F",2.342,5,1,4]
["S2248","Silmitasertib (CX-4945)","b11","L6200-05","in 10mM DMSO","Apoptosis related,Autophagy,Casein Kinase","Metabolism","Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.",349.77,"1009820-21-6",{"v":16,"d":"16.00"},45.74,"<1","N/A","http://selleckchem.com/products/cx-4945-silmitasertib.html","C19H12ClN3O2","free base","N/A","OC(=O)C1=CC2=C(C=C1)C3=CN=CC=C3C(=N2)NC4=CC(=CC=C4)Cl",4.157,3,1,3]
["S2250","(-)-Epigallocatechin Gallate","c11","L6200-05","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2252","(+)-Usniacin","d11","L6200-05","in 10mM DMSO","Others","Others","(+)-Usniacin (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.",344.32,"7562-61-0",{"v":4,"d":"4.00"},11.62,"<1","N/A","http://selleckchem.com/products/Usniacin-D-Usnic-acid.html","C18H16O7","free base","D-Usnic Acid","CC(=O)C1=C(O)C(=C(O)C2=C1OC3=CC(=O)C(=C(O)C23C)C(C)=O)C",1.087,4,3,2]
["S2254","4-Demethylepipodophyllotoxin(NSC-122819,VM-26)","e11","L6200-05","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.",400.38,"6559-91-7",{"v":80,"d":"80.00"},199.81,"N/A","N/A","http://selleckchem.com/products/4-Demethylepipodophyllotoxin.html","C21H20O8","free base","DMEP","COC1=C(O)C(=CC(=C1)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24)OC",1.886,6,2,3]
["S2258","Esculin","f11","L6200-05","in 10mM DMSO","Others","Others","Esculin (Aesculin) is a glucoside found in horse chestnuts.",340.28,"531-75-9",{"v":68,"d":"68.00"},199.84,{"v":2,"d":"2.00"},5.88,"http://selleckchem.com/products/Aesculin(Esculin).html","C15H16O9","free base","Aesculin","OCC1OC(OC2=C(O)C=C3OC(=O)C=CC3=C2)C(O)C(O)C1O",-0.514,4,5,3]
["S2259","Aloe-emodin","g11","L6200-05","in 10mM DMSO","IFN","Immunology & Inflammation","Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.",270.24,"481-72-1",{"v":3,"d":"3.00"},{"v":11.1,"d":"11.10"},"<1","N/A","http://selleckchem.com/products/Aloe-emodin.html","C15H10O5","free base","NSC 38628, Rhabarberone","OCC1=CC2=C(C(=C1)O)C(=O)C3=C(C=CC=C3O)C2=O",1.719,2,3,1]
["S2261","Andrographolide","h11","L6200-05","in 10mM DMSO","NF-κB","NF-κB","Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.",350.45,"5508-58-7",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/Andrographolide.html","C20H30O5","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C\\3C(O)COC3=O)C(=C)CCC12",2.056,2,3,3]
["S2262","Apigenin (LY 080400)","a2","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Apigenin (NSC 83244, LY 080400) is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.",270.24,"520-36-5",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Apigenin.html","C15H10O5","free base","NSC 83244","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",{"v":2.41,"d":"2.410"},2,3,1]
["S2263","Arbutin","b2","L6200-06","in 10mM DMSO","Tyrosinase","Proteases","Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.",272.25,"497-76-7",{"v":55,"d":"55.00"},202.02,{"v":55,"d":"55.00"},202.02,"http://selleckchem.com/products/Arbutin(Uva,-p-Arbutin).html","C12H16O7","free base","Uva,p-Arbutin, β-Arbutin","OCC1OC(OC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.584,2,5,3]
["S2265","Artesunate (WR-256283)","c2","L6200-06","in 10mM DMSO","ADC Cytotoxin,STAT","JAK/STAT","Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.",384.42,"88495-63-0",{"v":77,"d":"77.00"},{"v":200.3,"d":"200.30"},"<1","N/A","http://selleckchem.com/products/Artesunate.html","C19H28O8","free base","WR-256283","CC1CCC2C(C)C(OC3OC4(C)CCC1C23OO4)OC(=O)CCC(O)=O",1.845,7,0,5]
["S2266","Asiatic Acid","d2","L6200-06","in 10mM DMSO","p38 MAPK","MAPK","Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.",{"v":488.7,"d":"488.70"},"464-92-6",{"v":97,"d":"97.00"},198.49,"<1","N/A","http://selleckchem.com/products/Asiatic-acid.html","C30H48O5","free base","Dammarolic acid, Asiantic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(O)=O",4.435,1,3,2]
["S2268","Baicalein","e2","L6200-06","in 10mM DMSO","P450 (e.g. CYP17),PREP","Metabolism","Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.",270.24,"491-67-8",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Baicalein.html","C15H10O5","free base","N/A","OC1=C(O)C(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)O",{"v":2.41,"d":"2.410"},2,3,1]
["S2269","Baicalin (NSC-661431)","f2","L6200-06","in 10mM DMSO","GABA Receptor,PREP","Neuronal Signaling","Baicalin (NSC-661431) is a known prolyl endopeptidase inhibitor and affects the GABA receptors.",446.36,"21967-41-9",{"v":89,"d":"89.00"},199.39,"<1","N/A","http://selleckchem.com/products/Baicalin.html","C21H18O11","free base","N/A","OC1C(O)C(OC(C1O)C(O)=O)OC2=C(O)C(=C3C(=O)C=C(OC3=C2)C4=CC=CC=C4)O",0.608,5,5,4]
["S2270","Bergenin","g2","L6200-06","in 10mM DMSO","Others","Others","Bergenin (Cuscutin) is trihydroxybenzoic acid glycoside and the C-glycoside of 4-O-methyl gallic acid.",328.27,"477-90-7",{"v":66,"d":"66.00"},201.05,"<1","N/A","http://selleckchem.com/products/Bergenin-(Cuscutin).html","C14H16O9","free base","Cuscutin","COC1=C(O)C2=C(C=C1O)C(=O)OC3C(O)C(O)C(CO)OC23",-0.849,4,5,2]
["S2271","Berberine chloride (NSC 646666)","h2","L6200-06","in 10mM DMSO","Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase","Microbiology","Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.",371.81,"633-65-8",{"v":40,"d":"40.00"},107.58,"<1","N/A","http://selleckchem.com/products/Berberine-Hydrochloride.html","C20H18NO4.Cl","chloride","Natural Yellow 18 chloride","[Cl-].COC1=CC=C2C=C3C4=C(CC[N+]3=CC2=C1OC)C=C5OCOC5=C4",1.289,4,0,2]
["S2280","Chlorogenic Acid","a3","L6200-06","in 10mM DMSO","Others","Others","Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.",354.31,"327-97-9",{"v":71,"d":"71.00"},200.39,{"v":18,"d":"18.00"},{"v":50.8,"d":"50.80"},"http://selleckchem.com/products/Chlorogenic-acid.html","C16H18O9","free base","NSC 407296, Heriguard","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC(=C(O)C=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S2281","Chrysin","b3","L6200-06","in 10mM DMSO","Others","Others","Chrysin (NSC 407436) is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea).",254.24,"480-40-0",{"v":51,"d":"51.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/Chrysin.html","C15H10O4","free base","NSC 407436","OC1=CC2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=CC=C3",2.652,2,2,1]
["S2284","Colchicine (NSC 757)","c3","L6200-06","in 10mM DMSO","Microtubule Associated","Cell Cycle","Colchicine (NSC 757, Colchineos, Colchisol, Colcin) is a microtubule polymerization inhibitor with an IC50 of 3 nM.",399.44,"64-86-8",{"v":80,"d":"80.00"},200.28,{"v":80,"d":"80.00"},200.28,"http://selleckchem.com/products/colchicine.html","C22H25NO6","free base","Colchineos, Colchisol, Colcin,NSC 757","COC1=CC=C2C(=CC1=O)C(CCC3=C2C(=C(OC)C(=C3)OC)OC)NC(C)=O",2.044,6,1,5]
["S2285","Cryptotanshinone","d3","L6200-06","in 10mM DMSO","Apoptosis related,Autophagy,STAT","JAK/STAT","Cryptotanshinone is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.",296.36,"35825-57-1",{"v":5,"d":"5.00"},16.87,"<1","N/A","http://selleckchem.com/products/Cryptotanshinone.html","C19H20O3","free base","Tanshinone C","CC1COC2=C1C(=O)C(=O)C3=C4CCCC(C)(C)C4=CC=C23",3.761,3,0,0]
["S2289","Daidzin","e3","L6200-06","in 10mM DMSO","Dehydrogenase","Metabolism","Daidzin (Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside), a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).",416.38,"552-66-9",{"v":83,"d":"83.00"},199.34,"<1","N/A","http://selleckchem.com/products/Daidzin.html","C21H20O9","Free Base","Daidzoside, Daidzein 7-O-glucoside, Daidzein 7-glucoside","OCC1OC(OC2=CC3=C(C=C2)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",0.452,4,5,4]
["S2290","Dihydroartemisinin (DHA)","f3","L6200-06","in 10mM DMSO","Apoptosis related,Autophagy,NF-κB","NF-κB","Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.",284.35,"71939-50-9",{"v":56,"d":"56.00"},196.94,"<1","N/A","http://selleckchem.com/products/Dihydroartemisinin(DHA).html","C15H24O5","free base","Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol","CC1CCC2C(C)C(O)OC3OC4(C)CCC1C23OO4",1.621,4,0,0]
["S2293","DL-Carnitine HCl","g3","L6200-06","in 10mM DMSO","Others","Others","DL-Carnitine HCl is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.",197.66,"461-05-2",{"v":40,"d":"40.00"},202.37,{"v":40,"d":"40.00"},202.37,"http://selleckchem.com/products/DL-Carnitine-hydrochloride.html","C7H15NO3.HCl","Hydrochloride","N/A","[Cl-].C[N+](C)(C)CC(O)CC(O)=O",{"v":-4.49,"d":"-4.490"},1,1,4]
["S2295","Emodin","h3","L6200-06","in 10mM DMSO","Dehydrogenase","Metabolism","Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).",270.24,"518-82-1",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Emodin.html","C15H10O5","free base","N/A","CC1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(O)C=C3O)C2=O",2.568,2,3,0]
["S2298","Fisetin","a4","L6200-06","in 10mM DMSO","Sirtuin","Epigenetics","Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.",286.24,"528-48-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","http://selleckchem.com/products/Fisetin(Fustel).html","C15H10O6","free base","N/A","OC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC(=C(O)C=C3)O)O",1.872,2,4,1]
["S2301","Genistin (Genistoside)","b4","L6200-06","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Genistin (Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside) is an isoflavone found in a number of dietary plants like soy and kudzu. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of Estrogen Receptor α (ERα) signaling pathway.",432.37,"529-59-9",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/Genistin(Genistoside).html","C21H20O10","free base","Genistoside, Genistine, Genistein 7-glucoside, Genistein glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=CO3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.21,"d":"0.210"},4,6,4]
["S2302","Glycyrrhizin (NSC 167409)","c4","L6200-06","in 10mM DMSO","Dehydrogenase,High-mobility Group,MAO","Metabolism","Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).",822.93,"1405-86-3",{"v":100,"d":"100.00"},121.52,"<1","N/A","http://selleckchem.com/products/Glycyrrhizic-acid.html","C42H62O16","free base","N/A","CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(O)=O)OC6OC(C(O)C(O)C6OC7OC(C(O)C(O)C7O)C(O)=O)C(O)=O",2.417,8,5,7]
["S2308","Hesperetin","d4","L6200-06","in 10mM DMSO","Histamine Receptor,TGF-beta/Smad","TGF-beta/Smad","Hesperetin is a bioflavonoid and, to be more specific, a flavanone.",302.27,"520-33-2",{"v":60,"d":"60.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/Hesperetin.html","C16H14O6","free base","N/A","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.357,3,3,2]
["S2309","Hesperidin","e4","L6200-06","in 10mM DMSO","Others","Others","Hesperidin (Cirantin) is a flavanone glycoside found abundantly in citrus fruits.",610.56,"520-26-3",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/Hesperidin.html","C28H34O15","free base","Cirantin","COC1=CC=C(C=C1O)C2CC(=O)C3=C(O)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O2",-0.431,7,8,7]
["S2310","Honokiol (NSC 293100)","f4","L6200-06","in 10mM DMSO","Akt,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,HCV,MEK","PI3K/Akt/mTOR","Honokiol (NSC 293100) is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. Honokiol causes G0/G1 phase arrest, induces apoptosis, and autophagy via the ROS/ERK1/2 signaling pathway. Honokiol inhibits hepatitis C virus (HCV) infection. Phase 3.",266.33,"35354-74-6",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Honokiol.html","C18H18O2","free base","N/A","OC1=C(CC=C)C=C(C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2312","Icariin","g4","L6200-06","in 10mM DMSO","PDE","Metabolism","Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold more selective for PDE5 than PDE4.",676.66,"489-32-7",{"v":50,"d":"50.00"},73.89,"<1","N/A","http://selleckchem.com/products/Icariin.html","C33H40O15","free base","N/A","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O2)C(=C(OC5OC(CO)C(O)C(O)C5O)C=C4O)CC=C(C)C",0.983,7,8,9]
["S2313","Indole-3-carbinol","h4","L6200-06","in 10mM DMSO","NF-κB","NF-κB","Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.",147.18,"700-06-1",{"v":29,"d":"29.00"},197.04,{"v":7,"d":"7.00"},47.56,"http://selleckchem.com/products/Indole-3-carbinol.html","C9H9NO","free base","N/A","OCC1=C[NH]C2=C1C=CC=C2",1.518,0,2,1]
["S2314","Kaempferol (NSC 407289)","a5","L6200-06","in 10mM DMSO","Estrogen/progestogen Receptor,Fatty Acid Synthase","Endocrinology & Hormones","Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.",286.23,"520-18-3",{"v":57,"d":"57.00"},199.14,"<1","N/A","http://selleckchem.com/products/Kaempferol.html","C15H10O6","free base","Robigenin","OC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.872,2,4,1]
["S2316","Kinetin","b5","L6200-06","in 10mM DMSO","Others","Others","Kinetin (6-Furfuryladenine) is a type of cytokinin, a class of plant hormone that promotes cell division.",215.21,"525-79-1",{"v":8,"d":"8.00"},37.17,"<1","N/A","http://selleckchem.com/products/Kinetin(6-Furfuryladenine).html","C10H9N5O","free base","6-Furfuryladenine","C(NC1=NC=NC2=C1[NH]C=N2)C3=CC=CO3",0.875,4,2,3]
["S2320","Luteolin","c5","L6200-06","in 10mM DMSO","ADC Cytotoxin,PDE","Metabolism","Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively.",286.24,"491-70-3",{"v":57,"d":"57.00"},199.13,"<1","N/A","https://www.selleckchem.com/products/luteolin.html","C15H10O6","free base","Luteoline, Luteolol, Digitoflavone","OC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=C(O)C(=C3)O)O",2.168,2,4,1]
["S2321","Magnolol","d5","L6200-06","in 10mM DMSO","Fungal,NF-κB","NF-κB","Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.",266.33,"528-43-8",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Magnolol(2,2-Bichavicol).html","C18H18O2","free base","NSC 293099","OC1=C(C=C(CC=C)C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2322","(+)-Matrine","e5","L6200-06","in 10mM DMSO","Opioid Receptor","Neuronal Signaling","Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.",248.36,"519-02-8",{"v":49,"d":"49.00"},197.29,{"v":11,"d":"11.00"},44.29,"http://selleckchem.com/products/matrine.html","C15H24N2O","free base","N/A","O=C1CCCC2C3CCCN4CCCC(CN12)C34",1.417,1,0,0]
["S2325","Morin Hydrate","f5","L6200-06","in 10mM DMSO","Others","Others","Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).",320.25,"6202-27-3",{"v":64,"d":"64.00"},199.84,"<1","N/A","https://www.selleckchem.com/products/Morin-hydrate.html","C15H10O7.H2O","Hydrate","Aurantica","O.OC1=CC=C(C(=C1)O)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2",1.423,2,5,1]
["S2326","Myricetin","g5","L6200-06","in 10mM DMSO","MEK","MAPK","Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.",318.24,"529-44-2",{"v":63,"d":"63.00"},197.96,"<1","N/A","http://selleckchem.com/products/Myricetin(Cannabiscetin).html","C15H10O8","free base","Cannabiscetin","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC(=C(O)C(=C3)O)O)O)O",1.388,2,6,1]
["S2327","Myricitrin","h5","L6200-06","in 10mM DMSO","PKC","TGF-beta/Smad","Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects.",464.38,"17912-87-7",{"v":93,"d":"93.00"},200.27,"<1","N/A","http://selleckchem.com/products/Myricitrin(Myricitrine).html","C21H20O12","free base","Myricitrine","CC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C(=C4)O)O)C(O)C(O)C1O",0.347,4,8,3]
["S2328","Nalidixic acid","a6","L6200-06","in 10mM DMSO","Selection Antibiotics for Transfected Cell,Topoisomerase","DNA Damage/DNA Repair","Nalidixic acid (NSC-82174) is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.",232.24,"389-08-2",{"v":6,"d":"6.00"},25.84,"<1","N/A","http://selleckchem.com/products/Nalidixic-acid(NegGram).html","C12H12N2O3","free base","NSC-82174","CCN1C=C(C(O)=O)C(=O)C2=C1N=C(C)C=C2",1.176,3,0,2]
["S2329","Naringin","b6","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.",580.53,"10236-47-2",{"v":100,"d":"100.00"},172.26,"<1","N/A","http://selleckchem.com/products/Naringin(Naringoside).html","C27H32O14","free base","Naringoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C=C5)O)C(O)C(O)C1O",-0.415,6,8,6]
["S2331","Neohesperidin Dihydrochalcone (Nhdc)","c6","L6200-06","in 10mM DMSO","Others","Others","Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.",612.58,"20702-77-6",{"v":100,"d":"100.00"},163.24,"<1","N/A","http://selleckchem.com/products/Neohesperidin-dihydrochalcone(Nhdc).html","C28H36O15","free base","NCI-c60764","COC1=C(O)C=C(CCC(=O)C2=C(O)C=C(OC3OC(CO)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C=C2O)C=C1",-0.048,6,9,10]
["S2332","Neohesperidin","d6","L6200-06","in 10mM DMSO","ROS","Immunology & Inflammation","Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent., Neohesperidin (NSC 31048) 是一种抗氧化剂，在1,1-diphenyl-2-picryldydrazyl（DPPH）自由基清除测定中，IC50为22.31 μg/ml。",610.56,"13241-33-3",{"v":122,"d":"122.00"},199.82,"<1","N/A","http://selleckchem.com/products/Neohesperidin.html","C28H34O15","free base","NSC 31048","COC1=CC(=CC(=C1)C2CC(=O)C3=C(O)C=C(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)C=C3O2)O",-0.431,7,8,7]
["S2333","Nobiletin (NSC 76751)","e6","L6200-06","in 10mM DMSO","MMP","Proteases","Nobiletin (NSC 76751, Hexamethoxyflavone), a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.",402.39,"478-01-3",{"v":81,"d":"81.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/Nobiletin(Hexamethoxyflavone).html","C21H22O8","free base","Hexamethoxyflavone","COC1=C(OC)C=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.038,8,0,7]
["S2334","Oleanolic Acid","f6","L6200-06","in 10mM DMSO","Antiviral","Microbiology","Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.",{"v":456.7,"d":"456.70"},"508-02-1",{"v":21,"d":"21.00"},45.98,"<1","N/A","http://selleckchem.com/products/Oleanolic-Acid(Caryophyllin).html","C30H48O3","free base","Caryophyllin","CC1(C)CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",6.282,1,1,1]
["S2335","Oridonin (NSC-250682)","g6","L6200-06","in 10mM DMSO","Akt,Bacterial","PI3K/Akt/mTOR","Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.",364.43,"28957-04-2",{"v":72,"d":"72.00"},197.57,"<1","N/A","http://selleckchem.com/products/Oridonin(Isodonol).html","C20H28O6","free base","Isodonol, Rubescenin","CC1(C)CCC(O)C23COC(O)(C(O)C12)C45C(O)C(CCC34)C(=C)C5=O",{"v":0.2,"d":"0.200"},2,3,0]
["S2336","Orotic acid (6-Carboxyuracil)","h6","L6200-06","in 10mM DMSO","Others","Others","Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.",{"v":156.1,"d":"156.10"},"65-86-1",{"v":2,"d":"2.00"},12.81,"<1","N/A","http://selleckchem.com/products/Orotic-acid(6-Carboxyuracil).html","C5H4N2O4","free base","N/A","OC(=O)C1=CC(=O)NC(=O)N1",-1.152,3,2,1]
["S2338","Oxymatrine","a7","L6200-06","in 10mM DMSO","Immunology & Inflammation related","TGF-beta/Smad","Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.",264.36,"16837-52-8",{"v":53,"d":"53.00"},200.48,{"v":53,"d":"53.00"},200.48,"http://selleckchem.com/products/Oxymatrine(Matrine-N-oxide).html","C15H24N2O2","free base","Matrine N-oxide","[O-][N+]12CCCC3CN4C(CCCC4=O)C(CCC1)C23",{"v":0.61,"d":"0.610"},1,0,0]
["S2339","Paeonol","b7","L6200-06","in 10mM DMSO","MAO","Metabolism","Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.",166.17,"552-41-0",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/Paeonol(Peonol).html","C9H10O3","free base","Peonol","COC1=CC(=C(C=C1)C(C)=O)O",1.311,2,1,2]
["S2341","(-)-Parthenolide","c7","L6200-06","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2342","Phloretin (RJC 02792)","d7","L6200-06","in 10mM DMSO","SGLT","GPCR & G Protein","Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.",274.27,"60-82-2",{"v":54,"d":"54.00"},196.89,"<1","N/A","http://selleckchem.com/products/Phloretin(Dihydronaringenin).html","C15H14O5","free base","NSC 407292, Dihydronaringenin","OC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1",2.757,1,4,4]
["S2344","Piperine","e7","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.",285.34,"94-62-2",{"v":57,"d":"57.00"},199.76,"<1","N/A","http://selleckchem.com/products/Piperine(1-Piperoylpiperidine).html","C17H19NO3","free base","1-Piperoylpiperidine","O=C(\\C=C\\C=C\\C1=CC2=C(OCO2)C=C1)N3CCCCC3",2.864,3,0,3]
["S2347","Quercetin Dihydrate","f7","L6200-06","in 10mM DMSO","PI3K,Sirtuin","PI3K/Akt/mTOR","Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.",338.27,"6151-25-3",{"v":67,"d":"67.00"},198.07,"<1","N/A","http://selleckchem.com/products/Quercetin-dihydrate(Sophoretin).html","C15H10O7.2H2O","Dihydrate","Sophoretin","O.O.OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",1.216,2,5,1]
["S2348","Rotenone (Barbasco)","g7","L6200-06","in 10mM DMSO","Apoptosis related,Mitochondrial Metabolism,Mitophagy,NADPH-oxidase,ROS","Immunology & Inflammation","Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.",394.42,"83-79-4",{"v":78,"d":"78.00"},197.76,"N/A","N/A","http://selleckchem.com/products/rotenone-barbasco.html","C23H22O6","free base","Barbasco, Dactinol, Paraderil, Rotenon, Rotocide","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C(C=CC5=C4CC(O5)C(C)=C)C3=O",{"v":3.93,"d":"3.930"},6,0,3]
["S2349","Rutaecarpine","h7","L6200-06","in 10mM DMSO","COX","Neuronal Signaling","Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.",287.32,"84-26-4",{"v":24,"d":"24.00"},83.53,"<1","N/A","http://selleckchem.com/products/Rutaecarpine(Rutecarpine).html","C18H13N3O","free base","Rutecarpine","O=C1N2CCC3=C([NH]C4=C3C=CC=C4)C2=NC5=C1C=CC=C5",3.359,2,1,0]
["S2350","Rutin","a8","L6200-06","in 10mM DMSO","ADC Cytotoxin,Immunology & Inflammation related","Immunology & Inflammation","Rutin (Rutoside), a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.",610.52,"153-18-4",{"v":100,"d":"100.00"},163.79,"<1","N/A","http://selleckchem.com/products/Rutin(Rutoside).html","C27H30O16","free base","Rutoside","CC1OC(OCC2OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC(=C(O)C=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.158,6,10,6]
["S2351","Salicin","b8","L6200-06","in 10mM DMSO","COX","Neuronal Signaling","Salicin (Salicoside, Salicine) is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects. It is a natural, non-selective COX-1 and COX-2 inhibitor.",286.28,"138-52-3",{"v":57,"d":"57.00"},199.11,{"v":24,"d":"24.00"},83.83,"http://selleckchem.com/products/Salicin(Salicoside,-Salicine).html","C13H18O7","free base","Salicoside,Salicine","OCC1OC(OC2=CC=CC=C2CO)C(O)C(O)C1O",-0.947,2,5,4]
["S2354","Sclareol","c8","L6200-06","in 10mM DMSO","Others","Others","Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human cancer cell lines.",{"v":308.5,"d":"308.50"},"515-03-7",{"v":61,"d":"61.00"},197.73,"<1","N/A","http://selleckchem.com/products/Sclareol.html","C20H36O2","free base","N/A","CC1(C)CCCC2(C)C1CCC(C)(O)C2CCC(C)(O)C=C",{"v":4.27,"d":"4.270"},0,0,4]
["S2357","Silibinin (NSC 651520)","d8","L6200-06","in 10mM DMSO","Others","Others","Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.",482.44,"22888-70-6",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silibinin(Silybin).html","C25H22O10","free base","Silybin, Silibinin A, Silymarin I, Flavobin","COC1=CC(=CC=C1O)C2OC3=CC(=CC=C3OC2CO)C4OC5=CC(=CC(=C5C(=O)C4O)O)O",2.592,5,5,4]
["S2358","Silymarin","e8","L6200-06","in 10mM DMSO","Antioxidant","Angiogenesis","Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.",482.44,"65666-07-1",{"v":96,"d":"96.00"},198.99,"<1","N/A","http://selleckchem.com/products/Silymarin(Silybin-B).html","C25H22O10","free base","Silybin B","COC1=CC(=CC=C1O)C2OC3=CC=C(C=C3OC2CO)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S2363","Tangeretin","f8","L6200-06","in 10mM DMSO","Antioxidant","Apoptosis","Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.",372.37,"481-53-8",{"v":8,"d":"8.00"},21.48,"<1","N/A","http://selleckchem.com/products/Tangeretin(Tangeritin).html","C20H20O7","free base","Tangeritin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(OC)C(=C(OC)C(=C3O2)OC)OC",3.054,7,0,6]
["S2365","Tanshinone IIA","g8","L6200-06","in 10mM DMSO","Lipase","Metabolism","Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.",294.34,"568-72-9",{"v":5,"d":"5.00"},16.99,"<1","N/A","http://selleckchem.com/products/Tanshinone-IIA(Tanshinone-B).html","C19H18O3","free base","Tanshinone B","CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C",{"v":4.66,"d":"4.660"},3,0,0]
["S2369","Troxerutin","h8","L6200-06","in 10mM DMSO","NLR,ROS","Immunology & Inflammation","Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.",742.68,"7085-55-4",{"v":100,"d":"100.00"},134.65,{"v":100,"d":"100.00"},134.65,"http://selleckchem.com/products/Troxerutin.html","C33H42O19","free base","N/A","CC1OC(OCC2OC(OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(OCCO)C=C5)OCCO)C(O)C(O)C2O)C(O)C(O)C1O",{"v":-2.1,"d":"-2.100"},9,10,15]
["S2370","Ursolic Acid","a9","L6200-06","in 10mM DMSO","Others","Others","Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.",{"v":456.7,"d":"456.70"},"77-52-1",{"v":91,"d":"91.00"},199.26,"<1","N/A","http://selleckchem.com/products/Ursolic-acid(Malol).html","C30H48O3","free base","NSC 167406, NSC-4060, Prunol, Urson, Malol","CC1CC(C2CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",6.327,1,1,1]
["S2371","Vanillylacetone","b9","L6200-06","in 10mM DMSO","NF-κB","NF-κB","Vanillylacetone (NSC 15335) is similar in chemical structure to other flavor chemicals such as vanillin and eugenol and is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Vanillylacetone (Zingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.",194.23,"122-48-5",{"v":38,"d":"38.00"},195.64,{"v":10,"d":"10.00"},51.49,"http://selleckchem.com/products/Vanillylacetone.html","C11H14O3","free base","NSC 15335","COC1=CC(=CC=C1O)CCC(C)=O",1.792,2,1,4]
["S2375","Aloin","c9","L6200-06","in 10mM DMSO","Tyrosinase","Proteases","Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.",418.39,"1415-73-2",{"v":83,"d":"83.00"},198.38,{"v":83,"d":"83.00"},198.38,"http://selleckchem.com/products/Aloin(Barbaloin).html","C21H22O9","free base","Barbaloin, Barbalin","OCC1OC(C(O)C(O)C1O)C2C3=C(C(=CC=C3)O)C(=O)C4=C2C=C(CO)C=C4O",-0.404,2,7,3]
["S2379","Dioscin","d9","L6200-06","in 10mM DMSO","Others","Others","Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities.",869.04,"19057-60-4",{"v":100,"d":"100.00"},115.07,"<1","N/A","http://selleckchem.com/products/Dioscin(Collettiside-III).html","C45H72O16","free base","Collettiside III, Saponin","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",1.169,8,8,7]
["S2380","Diosmetin","e9","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants.",300.26,"520-34-3",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://selleckchem.com/products/Diosmetin(Luteolin-4-methyl-ether).html","C16H12O6","free base","Luteolin 4-methyl ether","COC1=CC=C(C=C1O)C2=CC(=O)C3=C(O)C=C(O)C=C3O2",2.394,3,3,2]
["S2382","Evodiamine","f9","L6200-06","in 10mM DMSO","NF-κB","NF-κB","Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.",303.36,"518-17-2",{"v":12,"d":"12.00"},39.56,"<1","N/A","http://www.selleck.cn/products/Evodiamine(Isoevodiamine).html","C19H17N3O","Free Base","Isoevodiamine","CN1C2N(CCC3=C2[NH]C4=CC=CC=C34)C(=O)C5=C1C=CC=C5",3.673,1,1,0]
["S2386","Indirubin (NSC 105327)","g9","L6200-06","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Indirubin (NSC 105327) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.",262.26,"479-41-4",{"v":53,"d":"53.00"},202.09,"<1","N/A","http://selleckchem.com/products/Indirubin.html","C16H10N2O2","free base","NSC 105327","O=C1NC2=CC=CC=C2\\C1=C3/NC4=C(C=CC=C4)C3=O",1.876,2,2,0]
["S2389","Naringin Dihydrochalcone","h9","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.",582.55,"18916-17-1",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://selleckchem.com/products/Naringin-Dihydrochalcone(Naringin-DC).html","C27H34O14","free base","N/A","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC(=C(C(=O)CCC4=CC=C(O)C=C4)C(=C3)O)O)C(O)C(O)C1O",-0.032,5,9,9]
["S2391","Quercetin (NSC 9221)","a10","L6200-06","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src","Epigenetics","Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.",302.24,"117-39-5",{"v":61,"d":"61.00"},201.83,"<1","N/A","http://selleckchem.com/products/Quercetin(Sophoretin).html","C15H10O7","Free Base","Sophoretin, C.I. 75720","OC1=CC(=C2C(=O)C(=C(OC2=C1)C3=CC=C(O)C(=C3)O)O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S2394","Naringenin","b10","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.",272.25,"480-41-1",{"v":54,"d":"54.00"},198.35,"<1","N/A","http://selleckchem.com/products/naringenin.html","C15H12O5","free base","NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol","OC1=CC=C(C=C1)C2CC(=O)C3=C(O)C=C(O)C=C3O2",2.373,2,3,1]
["S2396","Salidroside","c10","L6200-06","in 10mM DMSO","Mitophagy,mTOR,PREP","PI3K/Akt/mTOR","Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. Salidroside is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.",{"v":300.3,"d":"300.30"},"10338-51-9",{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},{"v":60,"d":"60.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/Salidroside-Rhodioloside.html","C14H20O7","free base","Rhodioloside","OCC1OC(OCCC2=CC=C(O)C=C2)C(O)C(O)C1O",-0.443,2,5,5]
["S2399","Dihydromyricetin","d10","L6200-06","in 10mM DMSO","GABA Receptor,ROS","Neuronal Signaling","Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.",320.25,"27200-12-0",{"v":64,"d":"64.00"},199.84,"<1","N/A","http://selleckchem.com/products/Dihydromyricetin-Ampeloptin.html","C15H12O8","free base","Ampeloptin","OC1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(O)C(=C3)O)O",1.237,2,6,1]
["S2400","Rheic Acid","e10","L6200-06","in 10mM DMSO","FTO,Immunology & Inflammation related","Immunology & Inflammation","Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.",284.22,"478-43-3",{"v":3,"d":"3.00"},10.56,"<1","N/A","http://www.selleck.cn/products/Rhein-Monorhein.html","C15H8O6","Free Base","Rhein, Monorhein, NSC 38629, Rheinic Acid","OC(=O)C1=CC(=C2C(=O)C3=C(C=CC=C3O)C(=O)C2=C1)O",1.954,3,2,1]
["S2401","Sodium Danshensu","f10","L6200-06","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.",220.15,"67920-52-9",{"v":7,"d":"7.00"},{"v":31.8,"d":"31.80"},{"v":2,"d":"2.00"},9.08,"http://selleckchem.com/products/Sodium-Danshensu.html","C9H9O5.Na","Sodium Salt","N/A","[Na+].OC(CC1=CC(=C(O)C=C1)O)C([O-])=O",-0.795,0,3,3]
["S2404","Isoliquiritigenin","g10","L6200-06","in 10mM DMSO","Aldose Reductase","Metabolism","Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM.",256.25,"961-29-5",{"v":12,"d":"12.00"},46.83,"<1","N/A","http://selleckchem.com/products/Isoliquiritigenin.html","C15H12O4","free base","N/A","OC1=CC=C(C=C1)\\C=C\\C(=O)C2=C(O)C=C(O)C=C2",2.975,1,3,3]
["S2405","Sophocarpine","h10","L6200-06","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.",246.35,"6483-15-4",{"v":49,"d":"49.00"},{"v":198.9,"d":"198.90"},{"v":6,"d":"6.00"},24.36,"http://selleckchem.com/products/Sophocarpine.html","C15H22N2O","free base","N/A","O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.394,1,0,0]
["S2406","Chrysophanic Acid","a11","L6200-06","in 10mM DMSO","EGFR,mTOR","Protein Tyrosine Kinase","Chrysophanic Acid (Chrysophanol) a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.",254.24,"481-74-3",{"v":5,"d":"5.00"},19.67,"<1","N/A","http://selleckchem.com/products/Chrysophanic-acid-Chrysophanol.html","C15H10O4","free base","Chrysophanol","CC1=CC2=C(C(=C1)O)C(=O)C3=C(O)C=CC=C3C2=O",{"v":2.81,"d":"2.810"},2,2,0]
["S2407","Curcumol","b11","L6200-06","in 10mM DMSO","JAK","JAK/STAT","Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.",236.35,"4871-97-0",{"v":47,"d":"47.00"},198.86,"<1","N/A","http://selleckchem.com/products/Curcumol.html","C15H24O2","free base","N/A","CC(C)C1CC23OC1(O)CC(=C)C2CCC3C",2.786,1,0,1]
["S2408","Cephalomannine","c11","L6200-06","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics","Others","Cephalomannine (Baccatin III) is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice.",{"v":831.9,"d":"831.90"},"71610-00-9",{"v":100,"d":"100.00"},120.21,"<1","N/A","http://selleckchem.com/products/cephalomannine.html","C45H53NO14","free base","Baccatin III","C/C=C(C)/C(=O)NC(C(O)C(=O)OC1CC2(O)C(OC(=O)C3=CC=CC=C3)C4C(C)(C(O)CC5OCC45OC(C)=O)C(=O)C(OC(C)=O)C(=C1C)C2(C)C)C6=CC=CC=C6",2.937,11,3,14]
["S2410","Paeoniflorin (NSC 178886)","d11","L6200-06","in 10mM DMSO","COX,HIF","Immunology & Inflammation","Paeoniflorin (NSC 178886,Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin reduces COX-2 expression. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.",480.46,"23180-57-6",{"v":96,"d":"96.00"},199.81,{"v":96,"d":"96.00"},199.81,"http://selleckchem.com/products/paeoniflorin.html","C23H28O11","free base","NSC 178886,Peoniflorin","CC12CC3(O)OC(O1)C4(COC(=O)C5=CC=CC=C5)C3CC24OC6OC(CO)C(O)C(O)C6O",-1.283,6,4,7]
["S2411","Geniposide","e11","L6200-06","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis.",388.37,"24512-63-8",{"v":78,"d":"78.00"},200.84,{"v":78,"d":"78.00"},200.84,"http://selleckchem.com/products/geniposide.html","C17H24O10","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C1CC=C3CO",-2.066,5,5,6]
["S2415","Astragaloside A","f11","L6200-06","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.",784.97,"83207-58-3",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://selleckchem.com/products/astragaloside-a.html","C41H68O14","free base","N/A","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O",-0.348,5,8,7]
["S2423","(S)-10-Hydroxycamptothecin","g11","L6200-06","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.",364.35,"19685-09-7",{"v":8,"d":"8.00"},21.96,"<1","N/A","http://selleckchem.com/products/10-hydroxycamptothecin.html","C20H16N2O5","free base","10-HCPT","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=CC(=CC=C5N=C34)O)C2=O",1.504,4,1,1]
["S2425","Apocynin (NSC 2146)","h11","L6200-06","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.",166.17,"498-02-2",{"v":33,"d":"33.00"},198.59,"<1","N/A","http://selleckchem.com/products/apocynin-acetovanillone.html","C9H10O3","free base","Acetovanillone, NSC 209524","COC1=C(O)C=CC(=C1)C(C)=O",1.311,2,1,2]
["S2443","Tolbutamide (HLS 831)","a2","L6200-07","in 10mM DMSO","Potassium Channel","Transmembrane Transporters","Tolbutamide (HLS 831) is an inhibitor of potassium channel, used for type II diabetes.",270.35,"64-77-7",{"v":54,"d":"54.00"},199.74,"<1","N/A","http://selleckchem.com/products/tolbutamide.html","C12H18N2O3S","free base","HLS 831","CCCCNC(=O)N[S](=O)(=O)C1=CC=C(C)C=C1",2.336,3,2,5]
["S2448","Gambogic Acid","b2","L6200-07","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.",628.75,"2752-65-0",{"v":100,"d":"100.00"},159.05,"<1","N/A","http://selleckchem.com/products/gambogic-acid.html","C38H44O8","free base","Guttatic Acid, Guttic Acid, Beta-Guttiferrin","CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(=C2C=C1)O)C(=O)C4=CC5CC6C(C)(C)OC(C\\C=C(C)/C(O)=O)(C5=O)C46O3",6.957,6,1,8]
["S2449","Colforsin","c2","L6200-07","in 10mM DMSO","Autophagy,cAMP,FXR","GPCR & G Protein","Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.",{"v":410.5,"d":"410.50"},"66575-29-9",{"v":82,"d":"82.00"},199.76,"<1","N/A","http://selleckchem.com/products/forskolin.html","C22H34O7","free base","Forskolin, HL 362, Coleonol","CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C3(O)C(=O)CC(C)(OC13C)C=C",0.837,4,2,3]
["S2450","Equol","d2","L6200-07","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.",242.27,"531-95-3",{"v":48,"d":"48.00"},198.13,"<1","N/A","http://selleckchem.com/products/equol.html","C15H14O3","free base","N/A","OC1=CC=C(C=C1)C2COC3=CC(=CC=C3C2)O",3.211,1,2,1]
["S2458","Clonidine HCl","e2","L6200-07","in 10mM DMSO","Adrenergic Receptor,Autophagy","Neuronal Signaling","Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.",{"v":266.5,"d":"266.50"},"4205-91-8",{"v":53,"d":"53.00"},198.87,{"v":53,"d":"53.00"},198.87,"http://selleckchem.com/products/Clonidine-hydrochloride(Catapres).html","C9H9Cl2N3.HCl","Hydrochloride","Kapvay","Cl.ClC1=C(NC2=NCCN2)C(=CC=C1)Cl",2.736,1,2,2]
["S2475","Imatinib (STI571)","f2","L6200-07","in 10mM DMSO","Autophagy,Bcr-Abl,c-Kit,PDGFR","Protein Tyrosine Kinase","Imatinib (STI571,Gleevec, Glivec, CGP057148B) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.",{"v":493.6,"d":"493.60"},"152459-95-5",{"v":33,"d":"33.00"},66.86,"<1","N/A","http://selleckchem.com/products/Imatinib(STI571).html","C29H31N7O","free base","STI571,Gleevec, Glivec, CGP057148B","CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C)C(=C3)NC4=NC=CC(=N4)C5=CC=CN=C5",{"v":4.22,"d":"4.220"},4,2,7]
["S2480","Loperamide HCl","g2","L6200-07","in 10mM DMSO","Autophagy,Opioid Receptor","Neuronal Signaling","Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.",{"v":513.5,"d":"513.50"},"34552-83-5",{"v":22,"d":"22.00"},42.84,"<1","N/A","http://selleckchem.com/products/Loperamide-hydrochloride.html","C29H33ClN2O2.HCl","Hydrochloride","ADL 2-1294,R-18553 hydrochloride","Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C3=CC=CC=C3)C4=CC=CC=C4",5.017,1,0,7]
["S2485","Mitoxantrone (NSC-301739) 2HCl","h2","L6200-07","in 10mM DMSO","Apoptosis related,COVID-19,PKC,Topoisomerase","DNA Damage/DNA Repair","Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor of type II topoisomerase and protein kinase C (PKC) with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50 of 0.42 μM. Mitoxantrone also induces apoptosis.",{"v":517.4,"d":"517.40"},"70476-82-3",{"v":89,"d":"89.00"},172.01,{"v":89,"d":"89.00"},172.01,"http://selleckchem.com/products/Mitoxantrone-Hydrochloride.html","C22H29ClN4O6.2HCl","Dihydrochloride","NSC-301739 2HCl","Cl.Cl.OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C3=C(O)C=CC(=C3C2=O)O",0.832,2,8,12]
["S2491","Nitrendipine","a3","L6200-07","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.",360.37,"39562-70-4",{"v":72,"d":"72.00"},199.79,"<1","N/A","http://selleckchem.com/products/Nitrendipine.html","C18H20N2O6","free base","Bayotensin","CCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC)C",2.115,4,1,7]
["S2492","Novobiocin Sodium (NSC 2382)","b3","L6200-07","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Topoisomerase","DNA Damage/DNA Repair","Novobiocin Sodium (NSC 2382, Albamycin, Cathomycin) is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.",634.61,"1476-53-5",{"v":100,"d":"100.00"},157.58,{"v":100,"d":"100.00"},157.58,"http://selleckchem.com/products/Novobiocin-sodium(Albamycin).html","C31H35N2O11.Na","Sodium Salt","Albamycin,Cathomycin,NSC 2382","[Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=C(NC(=O)C4=CC=C([O-])C(=C4)CC=C(C)C)C(=O)OC3=C2C)O)OC1(C)C",2.747,8,4,9]
["S2493","Olanzapine","c3","L6200-07","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.",312.44,"132539-06-1",{"v":62,"d":"62.00"},198.44,"<1","N/A","http://selleckchem.com/products/Olanzapine(Zyprexa).html","C17H20N4S","free base","LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera","CN1CCN(CC1)C2=NC3=C(NC4=C2C=C(C)S4)C=CC=C3",{"v":2.69,"d":"2.690"},1,1,1]
["S2505","Rosiglitazone (BRL-49653) maleate","d3","L6200-07","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",{"v":473.5,"d":"473.50"},"155141-29-0",{"v":94,"d":"94.00"},198.52,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-maleate.html","C18H19N3O3S.C4H4O4","Maleate","BRL-49653C","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=NC=CC=C3.OC(=O)\\C=C/C(O)=O",3.307,6,1,9]
["S2512","Tenoxicam","e3","L6200-07","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tenoxicam(Ro-12-0068) is a good HO. radicals scavenger with an IC50 of 56.7 μM.",337.38,"59804-37-4",{"v":68,"d":"68.00"},201.55,"<1","N/A","http://selleckchem.com/products/Tenoxicam(Mobiflex).html","C13H11N3O4S2","free base","Ro-12-0068","CN1C(=C(O)C2=C(C=CS2)[S]1(=O)=O)C(=O)NC3=CC=CC=N3",0.454,4,2,2]
["S2517","Maprotiline HCl","f3","L6200-07","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.",313.86,"10347-81-6",{"v":63,"d":"63.00"},200.73,"<1","N/A","http://selleckchem.com/products/Maprotiline-hydrochloride.html","C20H23N.HCl","Hydrochloride","N/A","Cl.CNCCCC12CCC(C3=CC=CC=C13)C4=C2C=CC=C4",4.498,0,1,4]
["S2526","Alizarin","g3","L6200-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.",240.21,"72-48-0",{"v":48,"d":"48.00"},199.83,"<1","N/A","http://selleckchem.com/products/Alizarin.html","C14H8O4","free base","Anthraquinonic","OC1=C(O)C2=C(C=C1)C(=O)C3=CC=CC=C3C2=O",2.324,2,2,0]
["S2528","Ciclopirox","h3","L6200-07","in 10mM DMSO","ATPase,Fungal","Transmembrane Transporters","Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator.",207.27,"29342-05-0",{"v":42,"d":"42.00"},202.63,"<1","N/A","http://selleckchem.com/products/Ciclopirox-Penlac.html","C12H17NO2","Free Base","HOE 296b, Penlac","CC1=CC(=O)N(O)C(=C1)C2CCCCC2",2.489,1,0,1]
["S2531","Asaraldehyde","a4","L6200-07","in 10mM DMSO","COX","Neuronal Signaling","Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.",{"v":196.2,"d":"196.20"},"4460-86-0",{"v":39,"d":"39.00"},198.78,"<1","N/A","http://selleckchem.com/products/Asaraldehyde-Asaronaldehyde.html","C10H12O4","free base","Asaronaldehyde","COC1=C(OC)C=C(C=O)C(=C1)OC",{"v":1.54,"d":"1.540"},4,0,4]
["S2532","L-Ascorbyl 6-palmitate","b4","L6200-07","in 10mM DMSO","N/A","Others","Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.",414.53,"137-66-6",{"v":83,"d":"83.00"},200.23,"<1","N/A","http://selleckchem.com/products/L-Ascorbyl-6-palmitate.html","C22H38O7","free base","N/A","CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(=C1O)O",5.268,4,3,18]
["S2553","5-Aminolevulinic acid HCl","c4","L6200-07","in 10mM DMSO","Others","Others","5-Aminolevulinic Acid HCl(5-ALA hydrochloride) is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.",167.59,"5451-09-2",{"v":34,"d":"34.00"},202.88,{"v":34,"d":"34.00"},202.88,"http://selleckchem.com/products/5-Aminolevulinic-acid-hydrochloride.html","C5H9NO3.HCl","Hydrochloride","5-ALA hydrochloride","Cl.NCC(=O)CCC(O)=O",-3.318,2,1,4]
["S2554","Daphnetin","d4","L6200-07","in 10mM DMSO","EGFR,PKA,PKC","Angiogenesis","Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.",178.14,"486-35-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/Daphnetin.html","C9H6O4","free base","N/A","OC1=CC=C2C=CC(=O)OC2=C1O",1.415,2,2,0]
["S2555","Clarithromycin","e4","L6200-07","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Clarithromycin (A-56268) is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.",747.95,"81103-11-9",{"v":25,"d":"25.00"},33.42,"<1","N/A","http://selleckchem.com/products/clarithromycin.html","C38H69NO13","free base","A-56268","CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(CC(C)C(=O)C(C)C(O)C1(C)O)OC",{"v":2.2,"d":"2.200"},9,3,8]
["S2556","Rosiglitazone (BRL 49653)","f4","L6200-07","in 10mM DMSO","Autophagy,Ferroptosis,PPAR,TRP Channel","Metabolism","Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.",357.43,"122320-73-4",{"v":71,"d":"71.00"},198.64,"<1","N/A","http://selleckchem.com/products/Rosiglitazone-Avandia.html","C18H19N3O3S","Free Base","BRL 49653","CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3",3.268,4,1,7]
["S2557","Terbinafine HCl","g4","L6200-07","in 10mM DMSO","Fungal","Microbiology","Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug.",327.89,"78628-80-5",{"v":66,"d":"66.00"},201.29,"<1","N/A","http://selleckchem.com/products/Terbinafine-hydrochloride-Lamisil.html","C21H25N.HCl","Hydrochloride","KWD 201,KWD 2019,TDT 067 hydrochloride","Cl.CN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC2=C1C=CC=C2",5.717,0,0,6]
["S2577","Phenacetin","h4","L6200-07","in 10mM DMSO","COX","Neuronal Signaling","Phenacetin (Acetophenetidin) is a non-opioid analgesic without anti-inflammatory properties.",179.22,"62-44-2",{"v":36,"d":"36.00"},200.87,"<1","N/A","http://selleckchem.com/products/phenacetin.html","C10H13NO2","free base","Acetophenetidin","CCOC1=CC=C(NC(C)=O)C=C1",1.282,2,1,3]
["S2579","Zidovudine","a5","L6200-07","in 10mM DMSO","CRISPR/Cas9,Reverse Transcriptase","Microbiology","Zidovudine (ZDV, Azidothymidine, NSC 602670,Retrovir) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.",267.24,"30516-87-1",{"v":53,"d":"53.00"},198.32,{"v":53,"d":"53.00"},198.32,"http://selleckchem.com/products/zidovudine-retrovir.html","C10H13N5O4","free base","Azidothymidine, NSC 602670,Retrovir","CC1=CN(C2CC(N=[N+]=[N-])C(CO)O2)C(=O)NC1=O",0.064,4,2,3]
["S2584","Clobetasol propionate","b5","L6200-07","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.",466.97,"25122-46-7",{"v":93,"d":"93.00"},199.16,"<1","N/A","http://selleckchem.com/products/clobetasol-propionate.html","C25H32ClFO5","free base","CGP9555, CCl 4725","CCC(=O)OC1(C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)CCl",3.958,4,1,5]
["S2586","Dimethyl Fumarate","c5","L6200-07","in 10mM DMSO","Nrf2","Immunology & Inflammation","Dimethyl fumarate (DMF,Tecfidera,BG-12) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.",144.13,"624-49-7",{"v":29,"d":"29.00"},201.21,"<1","N/A","http://selleckchem.com/products/dimethyl-Fumarate.html","C6H8O4","free base","DMF,Tecfidera,BG-12","COC(=O)\\C=C\\C(=O)OC",{"v":0.49,"d":"0.490"},4,0,4]
["S2590","Pioglitazone (AD-4833)","d5","L6200-07","in 10mM DMSO","PPAR","Metabolism","Pioglitazone (AD-4833, U 72107) is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ.",356.44,"111025-46-8",{"v":10,"d":"10.00"},28.06,"<1","N/A","https://www.selleckchem.com/products/pioglitazone.html","C19H20N2O3S","Free Base","U 72107","CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1",3.907,4,1,7]
["S2593","Tolvaptan","e5","L6200-07","in 10mM DMSO","Vasopressin Receptor","GPCR & G Protein","Tolvaptan (OPC-41061) is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM, used to treat hyponatremia.",448.94,"150683-30-0",{"v":89,"d":"89.00"},198.24,"<1","N/A","http://selleckchem.com/products/tolvaptan-opc-41061.html","C26H25ClN2O3","free base","OPC-41061","CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(O)C4=C3C=CC(=C4)Cl)C",5.127,2,2,3]
["S2602","Acemetacin","f5","L6200-07","in 10mM DMSO","COX","Neuronal Signaling","Acemetacin (K-708,TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.",415.82,"53164-05-9",{"v":83,"d":"83.00"},199.61,"<1","N/A","http://selleckchem.com/products/acemetacin-emflex.html","C21H18ClNO6","free base","K-708,TVX 1322","COC1=CC2=C(C=C1)[N](C(=C2CC(=O)OCC(O)=O)C)C(=O)C3=CC=C(Cl)C=C3",3.942,5,0,7]
["S2603","Tioxolone","g5","L6200-07","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.",168.17,"4991-65-5",{"v":34,"d":"34.00"},202.18,"<1","N/A","http://selleckchem.com/products/tioxolone.html","C7H4O3S","free base","Thioxolone","OC1=CC=C2SC(=O)OC2=C1",2.303,2,1,0]
["S2605","Idebenone","h5","L6200-07","in 10mM DMSO","ROS","Immunology & Inflammation","Idebenone (CV-2619) is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.",338.44,"58186-27-9",{"v":68,"d":"68.00"},200.92,"<1","N/A","http://selleckchem.com/products/idebenone.html","C19H30O5","free base","CV-2619","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCCO",3.836,4,1,12]
["S2606","Mifepristone (RU486)","a6","L6200-07","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2,Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","Mifepristone (RU486, C-1073, RU 38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.",429.59,"84371-65-3",{"v":85,"d":"85.00"},197.86,"<1","N/A","http://selleckchem.com/products/Mifepristone(Mifeprex).html","C29H35NO2","free base","RU486, C-1073, RU 38486, RU-486, Mifegyne","CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC12C)C5=CC=C(C=C5)N(C)C",5.655,1,0,3]
["S2610","Lonidamine (AF-1890)","b6","L6200-07","in 10mM DMSO","Carbohydrate Metabolism,Others","Metabolism","Lonidamine (AF 1890, Diclondazolic Acid, DICA) is an orally administered small molecule hexokinase inactivator.",321.16,"50264-69-2",{"v":64,"d":"64.00"},199.28,"<1","N/A","http://selleckchem.com/products/lonidamine.html","C15H10Cl2N2O2","free base","Diclondazolic Acid, DICA","OC(=O)C1=N[N](CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C13",{"v":4.65,"d":"4.650"},2,0,3]
["S2619","MG132","c6","L6200-07","in 10mM DMSO","Proteasome","Proteases","MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor.  MG132 also inhibits calpain (IC50=1.2 μM).",475.62,"1211877-36-9",{"v":90,"d":"90.00"},189.23,"<1","N/A","http://selleckchem.com/products/MG132.html","C26H41N3O5","free base","(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al","CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",4.371,5,3,15]
["S2621","AZD5438","d6","L6200-07","in 10mM DMSO","CDK","Cell Cycle","AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β.",371.46,"602306-29-6",{"v":74,"d":"74.00"},199.21,"<1","N/A","http://selleckchem.com/products/AZD5438.html","C18H21N5O2S","free base","N/A","CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)[S](C)(=O)=O)C",2.966,5,1,5]
["S2622","PP121","e6","L6200-07","in 10mM DMSO","Bcr-Abl,DNA-PK,mTOR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.",319.36,"1092788-83-4",{"v":64,"d":"64.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/PP121.html","C17H17N7","free base","N/A","NC1=NC=NC2=C1C(=N[N]2C3CCCC3)C4=CN=C5[NH]C=CC5=C4",2.583,4,2,2]
["S2624","OSI-027","f6","L6200-07","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1","N/A","http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2626","Rabusertib (LY2603618)","g6","L6200-07","in 10mM DMSO","Apoptosis related,Autophagy,Chk","Cell Cycle","Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.",{"v":436.3,"d":"436.30"},"911222-45-2",{"v":13,"d":"13.00"},{"v":29.8,"d":"29.80"},"<1","N/A","http://selleckchem.com/products/LY2603618-IC-83.html","C18H22BrN5O3","free base","IC-83","CC1=NC=C(NC(=O)NC2=C(OCC3CNCCO3)C=C(C)C(=C2)Br)N=C1",{"v":1.58,"d":"1.580"},5,3,5]
["S2627","Tubastatin A HCl","h6","L6200-07","in 10mM DMSO","HDAC","Epigenetics","Tubastatin A HCl (TSA) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).",371.86,"1310693-92-5",{"v":74,"d":"74.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/tubastatin-a-hcl.html","C20H21N3O2.HCl","Hydrochloride","TSA HCl","Cl.CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=C(C=C4)C(=O)NO",3.463,1,1,3]
["S2631","URB597","a7","L6200-07","in 10mM DMSO","FAAH","Metabolism","URB597 (KDS-4103) is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.",{"v":338.4,"d":"338.40"},"546141-08-6",{"v":68,"d":"68.00"},200.95,"<1","N/A","http://selleckchem.com/products/urb597.html","C20H22N2O3","free base","KDS-4103","NC(=O)C1=CC(=CC=C1)C2=CC=CC(=C2)OC(=O)NC3CCCCC3",3.972,3,2,5]
["S2635","CCT128930","b7","L6200-07","in 10mM DMSO","Akt,Apoptosis related,Autophagy","PI3K/Akt/mTOR","CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.",341.84,"885499-61-6",{"v":68,"d":"68.00"},198.92,"<1","N/A","http://selleckchem.com/products/cct128930.html","C18H20ClN5","free base","N/A","NC1(CCN(CC1)C2=C3C=C[NH]C3=NC=N2)CC4=CC=C(Cl)C=C4",2.813,2,2,3]
["S2636","A66","c7","L6200-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","A66 is a potent and specific p110α inhibitor with IC50 of 32 nM in a cell-free assay, >100 fold selectivity for p110α over other class-I PI3K isoforms.",393.53,"1166227-08-2",{"v":79,"d":"79.00"},200.75,"<1","N/A","http://selleckchem.com/products/a66.html","C17H23N5O2S2","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CSC(=N3)C(C)(C)C",2.383,4,2,4]
["S2639","SNX-2112 (PF-04928473)","d7","L6200-07","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.",464.48,"908112-43-6",{"v":93,"d":"93.00"},200.22,"<1","N/A","http://selleckchem.com/products/snx-2112.html","C23H27F3N4O3","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC(=C(C=C3)C(N)=O)NC4CCC(O)CC4",3.709,3,3,5]
["S2656","PF-04929113 (SNX-5422)","e7","L6200-07","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.",521.53,"908115-27-5",{"v":104,"d":"104.00"},199.41,"<1","N/A","http://selleckchem.com/products/pf-04929113.html","C25H30F3N5O4","free base","N/A","CC1(C)CC(=O)C2=C(C1)[N](N=C2C(F)(F)F)C3=CC=C(C(N)=O)C(=C3)NC4CCC(CC4)OC(=O)CN",3.126,5,3,8]
["S2658","Omipalisib (GSK2126458)","f7","L6200-07","in 10mM DMSO","Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.",{"v":505.5,"d":"505.50"},"1086062-66-9",{"v":100,"d":"100.00"},197.82,"<1","N/A","http://selleckchem.com/products/gsk2126458.html","C25H17F2N5O3S","free base","GSK458","COC1=NC=C(C=C1N[S](=O)(=O)C2=CC=C(F)C=C2F)C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3",3.705,7,1,6]
["S2660","MK-0752","g7","L6200-07","in 10mM DMSO","Beta Amyloid,Secretase","Proteases","MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.",{"v":442.9,"d":"442.90"},"471905-41-6",{"v":89,"d":"89.00"},200.95,"<1","N/A","http://selleckchem.com/products/mk-0752.html","C21H21ClF2O4S","free base","N/A","OC(=O)CCC1CCC(CC1)(C2=C(F)C=CC(=C2)F)[S](=O)(=O)C3=CC=C(Cl)C=C3",5.615,3,0,6]
["S2661","WYE-125132 (WYE-132)","h7","L6200-07","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.",{"v":519.6,"d":"519.60"},"1144068-46-1",{"v":104,"d":"104.00"},200.15,"<1","N/A","http://selleckchem.com/products/wye-125132.html","C27H33N7O4","free base","N/A","CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7",2.093,7,2,4]
["S2662","Foscenvivint (ICG-001)","a8","L6200-07","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Wnt/beta-catenin","Stem Cells & Wnt","Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.",548.63,"780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry)",{"v":100,"d":"100.00"},182.27,"<1","N/A","http://selleckchem.com/products/icg-001.html","C33H32N4O4","free base","N/A","OC1=CC=C(CC2N3C(CN(CC4=CC=CC5=C4C=CC=C5)C2=O)N(CCC3=O)C(=O)NCC6=CC=CC=C6)C=C1",4.065,3,2,6]
["S2665","Ciprofibrate","b8","L6200-07","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","Ciprofibrate (Win-35833) is a peroxisome proliferator-activated receptor agonist.",289.15,"52214-84-3",{"v":58,"d":"58.00"},200.59,"<1","N/A","http://selleckchem.com/products/ciprofibrate.html","C13H14Cl2O3","free base","Win-35833","CC(C)(OC1=CC=C(C=C1)C2CC2(Cl)Cl)C(O)=O",2.954,2,0,4]
["S2670","A-674563","c8","L6200-07","in 10mM DMSO","Akt,CDK,PKA","PI3K/Akt/mTOR","A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.",358.44,"552325-73-2",{"v":72,"d":"72.00"},200.87,{"v":72,"d":"72.00"},200.87,"http://selleckchem.com/products/a-674563.html","C22H22N4O","free base","N/A","CC1=N[NH]C2=C1C=C(C=C2)C3=CN=CC(=C3)OCC(N)CC4=CC=CC=C4",3.212,3,2,6]
["S2671","AS-252424","d8","L6200-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AS-252424 is a novel, potent PI3Kγ inhibitor with IC50 of 30 nM in a cell-free assay with 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β.",305.28,"900515-16-4",{"v":61,"d":"61.00"},199.82,"<1","N/A","http://selleckchem.com/products/as-252424.html","C14H8FNO4S","free base","N/A","OC1=C(C=CC(=C1)F)C2=CC=C(O2)\\C=C3/SC(=O)NC3=O",{"v":3.11,"d":"3.110"},3,2,2]
["S2673","Trametinib (GSK1120212)","e8","L6200-07","in 10mM DMSO","Apoptosis related,Autophagy,MEK","MAPK","Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.",615.39,"871700-17-3",{"v":22,"d":"22.00"},35.75,"<1","N/A","http://selleckchem.com/products/gsk1120212-jtp-74057.html","C26H23FIN5O4","free base","JTP-74057, Mekinist","CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(=CC=C5)NC(C)=O)C",3.176,4,2,5]
["S2679","Flavopiridol (L86-8275) HCl","f8","L6200-07","in 10mM DMSO","Autophagy,CDK,HIV","Cell Cycle","Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.",{"v":438.3,"d":"438.30"},"131740-09-5",{"v":88,"d":"88.00"},200.78,"<1","N/A","http://selleckchem.com/products/flavopiridol-hydrochloride.html","C21H20ClNO5.HCl","Hydrochloride","NSC 649890, Alvocidib, HMR-1275, DSP-2033","Cl.CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,2]
["S2681","AS-604850","g8","L6200-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.",285.22,"648449-76-7",{"v":57,"d":"57.00"},199.85,"<1","N/A","http://selleckchem.com/products/as-604850.html","C11H5F2NO4S","free base","N/A","FC1(F)OC2=C(O1)C=C(C=C2)\\C=C3/SC(=O)NC3=O",3.744,4,1,1]
["S2682","CAY10505","h8","L6200-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CAY10505 is dehydroxyl of AS-252424, which is a PI3Kγ inhibitor with IC50 of 33 nM.",289.28,"1218777-13-9",{"v":58,"d":"58.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://selleckchem.com/products/cay10505.html","C14H8FNO3S","free base","N/A","FC1=CC=C(C=C1)C2=CC=C(O2)\\C=C/3SC(=O)NC3=O",3.352,3,1,2]
["S2683","CHIR-124","a9","L6200-07","in 10mM DMSO","Chk","Cell Cycle","CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.",419.91,"405168-58-3",{"v":7,"d":"7.00"},16.67,"<1","N/A","http://selleckchem.com/products/chir-124.html","C23H22ClN5O","free base","N/A","ClC1=CC2=C(NC(=O)C(=C2NC3CN4CCC3CC4)C5=NC6=C([NH]5)C=CC=C6)C=C1",3.089,2,3,3]
["S2685","KW-2478","b9","L6200-07","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.",574.66,"819812-04-9",{"v":115,"d":"115.00"},200.12,"<1","N/A","http://selleckchem.com/products/kw-2478.html","C30H42N2O9","free base","N/A","CCC1=C(CC(=O)N(CCOC)CCOC)C(=C(O)C=C1O)C(=O)C2=CC=C(OCCN3CCOCC3)C(=C2)OC",2.673,7,2,16]
["S2686","NVP-BSK805 2HCl","c9","L6200-07","in 10mM DMSO","JAK","JAK/STAT","NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.",563.47,"1092499-93-8 (free base)",{"v":113,"d":"113.00"},200.54,{"v":3,"d":"3.00"},5.32,"http://selleckchem.com/products/nvp-bsk805.html","C27H28F2N6O.2HCl","HCl","BSK805","Cl.Cl.FC1=C(CN2CCOCC2)C(=CC(=C1)C3=C4N=C(C=NC4=CC=C3)C5=C[N](N=C5)C6CCNCC6)F",{"v":3.92,"d":"3.920"},4,1,5]
["S2688","R547","d9","L6200-07","in 10mM DMSO","CDK","Cell Cycle","R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.",441.45,"741713-40-6",{"v":60,"d":"60.00"},135.92,"<1","N/A","http://selleckchem.com/products/r547.html","C18H21F2N5O4S","free base","Ro 4584820","COC1=CC=C(F)C(=C1C(=O)C2=C(N)N=C(NC3CCN(CC3)[S](C)(=O)=O)N=C2)F",1.133,6,2,6]
["S2689","WAY-600","e9","L6200-07","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",494.59,"1062159-35-6",{"v":22,"d":"22.00"},44.48,"<1","N/A","http://selleckchem.com/products/way-600.html","C28H30N8O","free base","N/A","C1CN(CCO1)C2=NC(=NC3=C2C=N[N]3C4CCN(CC4)CC5=CC=CN=C5)C6=CC7=C([NH]C=C7)C=C6",2.946,5,1,5]
["S2692","TG101209","f9","L6200-07","in 10mM DMSO","c-RET,FLT3,JAK","JAK/STAT","TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.",509.67,"936091-14-4",{"v":102,"d":"102.00"},200.13,"<1","N/A","http://selleckchem.com/products/tg101209.html","C26H35N7O2S","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C(C)C(=N3)NC4=CC(=CC=C4)[S](=O)(=O)NC(C)(C)C)C=C2",4.659,4,3,8]
["S2693","Resminostat","g9","L6200-07","in 10mM DMSO","HDAC","Epigenetics","Resminostat (RAS2410) dose-dependently and selectively inhibits HDAC1/3/6 with IC50 of 42.5 nM/50.1 nM/71.8 nM, less potent to HDAC8 with IC50 of 877 nM.",{"v":349.4,"d":"349.40"},"864814-88-0",{"v":70,"d":"70.00"},200.34,"<1","N/A","http://selleckchem.com/products/resminostat-ras2410.html","C16H19N3O4S","free base","RAS2410","CN(C)CC1=CC=C(C=C1)[S](=O)(=O)[N]2C=CC(=C2)\\C=C\\C(=O)NO",1.837,3,1,6]
["S2696","Apitolisib (GDC-0980)","h9","L6200-07","in 10mM DMSO","Apoptosis related,Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.",{"v":498.6,"d":"498.60"},"1032754-93-0",{"v":20,"d":"20.00"},40.11,"<1","N/A","http://selleckchem.com/products/GDC-0980-RG7422.html","C23H30N8O3S","free base","RG7422, GNE 390","CC(O)C(=O)N1CCN(CC1)CC2=C(C)C3=NC(=NC(=C3S2)N4CCOCC4)C5=CN=C(N)N=C5",1.013,6,2,5]
["S2697","A-769662","a10","L6200-07","in 10mM DMSO","AMPK,Fatty Acid Synthase","PI3K/Akt/mTOR","A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.",360.39,"844499-71-4",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/a-769662.html","C20H12N2O3S","free base","N/A","OC1=CC=CC=C1C2=CC=C(C=C2)C3=CSC4=C3C(=C(C#N)C(=O)N4)O",3.135,1,3,2]
["S2699","CH5132799","b10","L6200-07","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CH5132799 (MEN1611, PA799) inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.",377.42,"1007207-67-1",{"v":12,"d":"12.00"},31.79,"<1","N/A","http://selleckchem.com/products/ch5132799.html","C15H19N7O3S","free base","MEN1611, PA799","C[S](=O)(=O)N1CCC2=C(N=C(N=C12)N3CCOCC3)C4=CN=C(N)N=C4",0.095,7,1,3]
["S2700","Tirbanibulin","c10","L6200-07","in 10mM DMSO","Src","Angiogenesis","Tirbanibulin(KX2-391,KX 01), the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Phase 2.",431.53,"897016-82-9",{"v":86,"d":"86.00"},199.29,"<1","N/A","http://selleckchem.com/products/kx2-391.html","C26H29N3O3","free base","KX2-391,KX 01","O=C(CC1=CC=C(C=N1)C2=CC=C(OCCN3CCOCC3)C=C2)NCC4=CC=CC=C4",3.262,4,1,9]
["S2703","GSK1838705A","d10","L6200-07","in 10mM DMSO","ALK,IGF-1R","Protein Tyrosine Kinase","GSK1838705A is a potent IGF-1R inhibitor with IC50 of 2.0 nM, modestly potent to IR and ALK with IC50 of 1.6 nM and 0.5 nM, respectively, and little activity to other protein kinases.",532.57,"1116235-97-2",{"v":107,"d":"107.00"},200.91,"<1","N/A","http://selleckchem.com/products/gsk1838705a.html","C27H29FN8O3","free base","N/A","CNC(=O)C1=C(F)C=CC=C1NC2=C3C=C[NH]C3=NC(=N2)NC4=C(OC)C=C5CCN(C(=O)CN(C)C)C5=C4",3.508,5,4,8]
["S2711","Dibenzazepine (YO-01027)","e10","L6200-07","in 10mM DMSO","Notch,Secretase","Proteases","Dibenzazepine (YO-01027, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM  in cell-free assays for APPL and Notch cleavage, respectively.",463.48,"209984-56-5",{"v":92,"d":"92.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/yo-01027.html","C26H23F2N3O3","free base","DBZ","CC(NC(=O)CC1=CC(=CC(=C1)F)F)C(=O)NC2C(=O)N(C)C3=C(C=CC=C3)C4=C2C=CC=C4",3.277,3,2,5]
["S2713","Geldanamycin (NSC 122750)","f10","L6200-07","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Antiviral,Autophagy,HSP (HSP90)","Cytoskeletal Signaling","Geldanamycin (NSC 122750) is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses.",560.64,"30562-34-6",{"v":36,"d":"36.00"},64.21,"<1","N/A","http://selleckchem.com/products/geldanamycin.html","C29H40N2O9","free base","NSC 122750","COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)\\C(=C\\C=C\\C(OC)C(OC(N)=O)\\C(=C\\C(C)C1O)C)C)C2=O",{"v":2.36,"d":"2.360"},8,3,5]
["S2714","LY411575","g10","L6200-07","in 10mM DMSO","Apoptosis related,Notch,Secretase","Proteases","LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells. LY411575 induces apoptosis.",479.48,"209984-57-6",{"v":95,"d":"95.00"},198.13,"<1","N/A","http://selleckchem.com/products/ly-411575.html","C26H23F2N3O4","free base","N/A","CC(NC(=O)C(O)C1=CC(=CC(=C1)F)F)C(=O)NC2C(=O)N(C)C3=C(C=CC=C3)C4=C2C=CC=C4",2.625,3,3,5]
["S2718","TAK-901","h10","L6200-07","in 10mM DMSO","Aurora Kinase","Cell Cycle","TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.",504.64,"934541-31-8",{"v":101,"d":"101.00"},200.14,"<1","N/A","http://selleckchem.com/products/tak-901.html","C28H32N4O3S","free base","N/A","CC[S](=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C)C3=C2C4=C([NH]3)N=CC(=C4)C)C(=O)NC5CCN(C)CC5",4.056,4,2,5]
["S2719","AMG-900","a11","L6200-07","in 10mM DMSO","Aurora Kinase","Cell Cycle","AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.",503.58,"945595-80-2",{"v":100,"d":"100.00"},198.58,"<1","N/A","http://selleckchem.com/products/amg-900.html","C28H21N7OS","free base","N/A","CC1=CSC(=C1)C2=NN=C(NC3=CC=C(OC4=C(C=CC=N4)C5=NC(=NC=C5)N)C=C3)C6=C2C=CC=C6",6.487,6,2,6]
["S2726","PH-797804","b11","L6200-07","in 10mM DMSO","p38 MAPK","MAPK","PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.",{"v":477.3,"d":"477.30"},"586379-66-0",{"v":96,"d":"96.00"},201.13,"<1","N/A","http://selleckchem.com/products/ph-797804.html","C22H19BrF2N2O3","free base","N/A","CNC(=O)C1=CC(=C(C)C=C1)N2C(=CC(=C(Br)C2=O)OCC3=CC=C(F)C=C3F)C",3.801,3,1,5]
["S2729","SB415286","c11","L6200-07","in 10mM DMSO","Apoptosis related,GSK-3","PI3K/Akt/mTOR","SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. SB415286 causes MM cell growth arrest and apoptosis.",359.72,"264218-23-7",{"v":72,"d":"72.00"},200.16,"<1","N/A","http://selleckchem.com/products/sb-415286.html","C16H10ClN3O5","free base","N/A","OC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C3=C(C=CC=C3)[N+]([O-])=O)C=C1",{"v":2.49,"d":"2.490"},2,3,4]
["S2730","Crenolanib (CP-868596)","d11","L6200-07","in 10mM DMSO","FLT3,Mitophagy,PDGFR","Protein Tyrosine Kinase","Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.",443.54,"670220-88-9",{"v":88,"d":"88.00"},{"v":198.4,"d":"198.40"},"<1","N/A","http://selleckchem.com/products/crenolanib-cp-868596.html","C26H29N5O2","free base","ARO 002","CC1(COC1)COC2=CC3=C(C=C2)[N](C=N3)C4=NC5=C(C=CC=C5C=C4)N6CCC(N)CC6",3.192,4,1,5]
["S2731","AZ 3146","e11","L6200-07","in 10mM DMSO","MPS1","Cell Cycle","AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.",452.55,"1124329-14-1",{"v":28,"d":"28.00"},61.87,"<1","N/A","http://selleckchem.com/products/az-3146.html","C24H32N6O3","free base","N/A","COC1=C(NC2=NC3=C(C=N2)N(C)C(=O)N3C4CCCC4)C=CC(=C1)OC5CCN(C)CC5",3.416,5,1,6]
["S2736","Fedratinib (TG101348)","f11","L6200-07","in 10mM DMSO","Apoptosis related,c-RET,FLT3,JAK","JAK/STAT","Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.",524.68,"936091-26-8",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/Fedratinib-SAR302503-TG101348.html","C27H36N6O3S","free base","SAR302503","CC1=C(NC2=CC=CC(=C2)[S](=O)(=O)NC(C)(C)C)N=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=C1",5.123,5,3,11]
["S2738","PAC-1","g11","L6200-07","in 10mM DMSO","Caspase","Apoptosis","PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.",392.49,"315183-21-2",{"v":78,"d":"78.00"},198.73,"<1","N/A","http://selleckchem.com/products/pac-1.html","C23H28N4O2","free base","N/A","OC1=C(CC=C)C=CC=C1/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3",3.331,2,2,8]
["S2740","GSK1070916","h11","L6200-07","in 10mM DMSO","Aurora Kinase","Cell Cycle","GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.",507.63,"942918-07-2",{"v":93,"d":"93.00"},{"v":183.2,"d":"183.20"},"<1","N/A","http://selleckchem.com/products/gsk1070916.html","C30H33N7O","free base","N/A","CC[N]1C=C(C2=C3C=C([NH]C3=NC=C2)C4=CC=CC(=C4)CN(C)C)C(=N1)C5=CC=C(NC(=O)N(C)C)C=C5",4.841,3,2,7]
["S2741","Niraparib (MK-4827)","a2","L6200-08","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.",320.39,"1038915-60-4",{"v":64,"d":"64.00"},199.76,"<1","N/A","http://selleckchem.com/products/mk-4827.html","C19H20N4O","Free Base","N/A","NC(=O)C1=CC=CC2=C[N](N=C12)C3=CC=C(C=C3)C4CCCNC4",2.618,2,2,3]
["S2742","PHA-767491 HCl","b2","L6200-08","in 10mM DMSO","CDK","Cell Cycle","PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.",{"v":249.7,"d":"249.70"},"942425-68-5",{"v":24,"d":"24.00"},96.12,"<1","N/A","http://selleckchem.com/products/pha-767491.html","C12H11N3O.HCl","HCl","CAY10572, NMS 1116354","O=C1NCCC2=C1C=C([NH]2)C3=CC=NC=C3",1.252,2,2,1]
["S2743","PF-04691502","c2","L6200-08","in 10mM DMSO","Akt,Apoptosis related,mTOR,PI3K","PI3K/Akt/mTOR","PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.",425.48,"1013101-36-4",{"v":14,"d":"14.00"},{"v":32.9,"d":"32.90"},"<1","N/A","http://selleckchem.com/products/pf-04691502.html","C22H27N5O4","free base","PF4691502","COC1=CC=C(C=N1)C2=CC3=C(C)N=C(N)N=C3N(C4CCC(CC4)OCCO)C2=O",1.616,6,2,6]
["S2745","CHIR-98014","d2","L6200-08","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","CHIR-98014 (CT98014) is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.",486.31,"252935-94-7",{"v":8,"d":"8.00"},16.45,"<1","N/A","http://selleckchem.com/products/chir-98014.html","C20H17Cl2N9O2","free base","CT98014","NC1=NC(=CC=C1[N+]([O-])=O)NCCNC2=NC=C([N]3C=CN=C3)C(=N2)C4=CC=C(Cl)C=C4Cl",3.859,4,3,8]
["S2747","AMG-458","e2","L6200-08","in 10mM DMSO","c-Met","Protein Tyrosine Kinase","AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.",539.58,"913376-83-7",{"v":21,"d":"21.00"},38.92,"<1","N/A","http://selleckchem.com/products/amg458.html","C30H29N5O5","free base","N/A","COC1=CC2=NC=CC(=C2C=C1)OC3=CN=C(NC(=O)C4=C(C)N(CC(C)(C)O)N(C4=O)C5=CC=CC=C5)C=C3",3.125,6,1,8]
["S2749","BGT226 (NVP-BGT226) maleate","f2","L6200-08","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.",{"v":650.6,"d":"650.60"},"1245537-68-1",{"v":30,"d":"30.00"},46.11,"<1","N/A","http://selleckchem.com/products/nvp-bgt226.html","C28H25F3N6O2.C4H4O","maleate","N/A","COC1=NC=C(C=C1)C2=CC=C3N=CC4=C(N(C(=O)N4C)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F)C3=C2.OC(=O)\\C=C/C(O)=O",1.618,6,1,7]
["S2750","GW788388","g2","L6200-08","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.",425.48,"452342-67-5",{"v":15,"d":"15.00"},35.25,"<1","N/A","http://selleckchem.com/products/gw788388.html","C25H23N5O2","free base","N/A","O=C(NC1CCOCC1)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C[NH]N=C4C5=NC=CC=C5",2.862,5,2,5]
["S2751","Milciclib (PHA-848125)","h2","L6200-08","in 10mM DMSO","Autophagy,CDK","Cell Cycle","Milciclib (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.",460.57,"802539-81-7",{"v":92,"d":"92.00"},199.75,"<1","N/A","http://selleckchem.com/products/pha-848125.html","C25H32N8O","free base","N/A","CNC(=O)C1=N[N](C)C2=C1C(C)(C)CC3=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N=C23",3.825,4,2,4]
["S2754","Xevinapant (AT406)","a3","L6200-08","in 10mM DMSO","E3 Ligase ,IAP","Apoptosis","Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.",561.71,"1071992-99-8",{"v":100,"d":"100.00"},178.03,"<1","N/A","http://selleckchem.com/products/at-406.html","C32H43N5O4","free base","ARRY-334543, Debio1143, SM-406","CNC(C)C(=O)NC1CN(CCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C",2.264,4,3,9]
["S2757","Evofosfamide (TH-302)","b3","L6200-08","in 10mM DMSO","Others","Others","Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.",449.04,"918633-87-1",{"v":90,"d":"90.00"},200.43,{"v":10,"d":"10.00"},22.27,"http://selleckchem.com/products/th-302.html","C9H16Br2N5O4P","free base","Evofosfamide","C[N]1C(=CN=C1[N+]([O-])=O)CO[P](=O)(NCCBr)NCCBr",0.537,3,2,10]
["S2759","Fimepinostat (CUDC-907)","c3","L6200-08","in 10mM DMSO","Apoptosis related,HDAC,PI3K","Cytoskeletal Signaling","CUDC-907 is a dual PI3K and HDAC inhibitor for PI3Kα and HDAC1/2/3/10 with IC50 of 19 nM and 1.7 nM/5 nM/1.8 nM/2.8 nM, respectively. CUDC-907 induces cell cycle arrest and apoptosis in breast cancer cells. Phase 1.",508.55,"1339928-25-4",{"v":102,"d":"102.00"},200.57,"<1","N/A","http://selleckchem.com/products/pi3k-hdac-inhibitor-i.html","C23H24N8O4S","free base","N/A","COC1=CC=C(C=N1)C2=NC3=C(SC(=C3)CN(C)C4=NC=C(C=N4)C(=O)NO)C(=N2)N5CCOCC5",2.303,8,1,7]
["S2768","Dinaciclib (SCH727965)","d3","L6200-08","in 10mM DMSO","Caspase,CDK","Cell Cycle","Dinaciclib (SCH727965, PS-095760) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.",396.49,"779353-01-4",{"v":26,"d":"26.00"},65.58,"<1","N/A","http://selleckchem.com/products/dinaciclib-sch727965.html","C21H28N6O2","free base","PS-095760","CCC1=C2N=C(C=C(NCC3=CC=C[N+](=C3)[O-])[N]2N=C1)N4CCCCC4CCO",2.152,2,2,7]
["S2770","MK-5108 (VX-689)","e3","L6200-08","in 10mM DMSO","Aurora Kinase,Autophagy","Cell Cycle","MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.",461.94,"1010085-13-8",{"v":92,"d":"92.00"},199.16,"<1","N/A","http://selleckchem.com/products/mk-5108-vx-689.html","C22H21ClFN3O3S","free base","N/A","OC(=O)C1(CCC(CC1)OC2=C(F)C(=CC=C2)Cl)CC3=CC=CC(=N3)NC4=NC=CS4",5.574,4,1,7]
["S2775","Nocodazole (R17934)","f3","L6200-08","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,CRISPR/Cas9,Microtubule Associated","Cytoskeletal Signaling","Nocodazole (R17934, Oncodazole, NSC238159) is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole induces apoptosis.",301.32,"31430-18-9",{"v":7,"d":"7.00"},23.23,"<1","N/A","http://selleckchem.com/products/nocodazole.html","C14H11N3O3S","free base","Oncodazole, NSC238159","COC(=O)NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CS3",3.008,4,2,4]
["S2776","Devimistat (CPI-613)","g3","L6200-08","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells. Phase 2.",388.59,"95809-78-2",{"v":77,"d":"77.00"},198.15,"<1","N/A","http://selleckchem.com/products/cpi-613.html","C22H28O2S2","free base","N/A","OC(=O)CCCCC(CCSCC1=CC=CC=C1)SCC2=CC=CC=C2",{"v":5.63,"d":"5.630"},1,0,13]
["S2777","PF-5274857","h3","L6200-08","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.",436.96,"1373615-35-0",{"v":93,"d":"93.00"},212.83,{"v":93,"d":"93.00"},212.83,"http://selleckchem.com/products/pf-5274857.html","C20H25ClN4O3S","free base","N/A","CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CC[S](C)(=O)=O)C",2.744,5,0,5]
["S2779","M344","a4","L6200-08","in 10mM DMSO","HDAC","Cytoskeletal Signaling","M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.",307.39,"251456-60-7",{"v":62,"d":"62.00"},{"v":201.7,"d":"201.70"},"<1","N/A","http://selleckchem.com/products/m344.html","C16H25N3O3","free base","N/A","CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO",2.004,2,2,9]
["S2780","I-BET151 (GSK1210151A)","b4","L6200-08","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","I-BET151 (GSK1210151A) is a novel selective BET inhibitor for BRD2, BRD3 and BRD4 with IC50 of 0.5 μM, 0.25 μM, and 0.79 μM in cell-free assays, respectively.",415.44,"1300031-49-5",{"v":83,"d":"83.00"},199.79,"<1","N/A","http://www.selleck.cn/products/i-bet151-gsk1210151a.html","C23H21N5O3","Free Base","N/A","COC1=C(C=C2N=CC3=C(N(C(C)C4=CC=CC=N4)C(=O)N3)C2=C1)C5=C(C)ON=C5C",2.601,6,1,4]
["S2781","RITA (NSC 652287)","c4","L6200-08","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2783","Vistusertib (AZD2014)","d4","L6200-08","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.",462.54,"1009298-59-2",{"v":38,"d":"38.00"},82.16,"<1","N/A","http://selleckchem.com/products/azd2014.html","C25H30N6O3","free base","N/A","CNC(=O)C1=CC=CC(=C1)C2=CC=C3C(=N2)N=C(N=C3N4CCOCC4C)N5CCOCC5C",3.103,6,1,4]
["S2787","Laquinimod","e4","L6200-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.",{"v":356.8,"d":"356.80"},"248281-84-7",{"v":61,"d":"61.00"},170.96,"<1","N/A","http://selleckchem.com/products/laquinimod-abr-215062.html","C19H17ClN2O3","free base","ABR-215062, LAQ","CCN(C(=O)C1=C(O)C2=C(C=CC=C2Cl)N(C)C1=O)C3=CC=CC=C3",2.884,2,1,3]
["S2789","Tofacitinib (CP-690550)","f4","L6200-08","in 10mM DMSO","Apoptosis related,JAK","JAK/STAT","Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.",312.37,"477600-75-2",{"v":62,"d":"62.00"},198.48,"<1","N/A","http://selleckchem.com/products/tofacitinib-cp-690550.html","C16H20N6O","free base","Tasocitinib","CC1CCN(CC1N(C)C2=C3C=C[NH]C3=NC=N2)C(=O)CC#N",1.512,3,1,3]
["S2791","Sotrastaurin (AEB071)","g4","L6200-08","in 10mM DMSO","PKC","TGF-beta/Smad","Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2.",438.48,"425637-18-9",{"v":87,"d":"87.00"},198.41,"<1","N/A","http://selleckchem.com/products/sotrastaurin-aeb071.html","C25H22N6O2","free base","AEB071","CN1CCN(CC1)C2=NC(=C3C=CC=CC3=N2)C4=C(C(=O)NC4=O)C5=C[NH]C6=C5C=CC=C6",3.483,4,2,3]
["S2794","Sofosbuvir (GS-7977)","h4","L6200-08","in 10mM DMSO","DNA/RNA Synthesis,HCV Protease","DNA Damage/DNA Repair","Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.",529.45,"1190307-88-0",{"v":100,"d":"100.00"},188.88,{"v":11,"d":"11.00"},20.78,"http://selleckchem.com/products/psi-7977-gs-7977.html","C22H29FN3O9P","free base","PSI-7977","CC(C)OC(=O)C(C)N[P](=O)(OCC1OC(N2C=CC(=O)NC2=O)C(C)(F)C1O)OC3=CC=CC=C3",0.921,7,3,11]
["S2796","WP1066","a5","L6200-08","in 10mM DMSO","Apoptosis related,JAK,STAT","JAK/STAT","WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.",356.22,"857064-38-1",{"v":71,"d":"71.00"},199.32,"<1","N/A","http://selleckchem.com/products/wp1066.html","C17H14BrN3O","free base","N/A","CC(NC(=O)\\C(=C\\C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",3.566,2,1,4]
["S2797","Lonafarnib (SCH66336)","b5","L6200-08","in 10mM DMSO","Ras,Transferase","Metabolism","Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.",638.82,"193275-84-2",{"v":127,"d":"127.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/lonafarnib-sch66336.html","C27H31Br2ClN4O2","free base","SCH66336","NC(=O)N1CCC(CC1)CC(=O)N2CCC(CC2)C3C4=C(CCC5=C3C(=CC(=C5)Cl)Br)C=C(Br)C=N4",5.271,3,1,3]
["S2799","Daporinad","c5","L6200-08","in 10mM DMSO","Autophagy,NAMPT,Transferase","Metabolism","Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.",391.51,"658084-64-1",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://www.selleck.cn/products/apo866-fk866.html","C24H29N3O2","Free Base","FK866, APO866","O=C(NCCCCC1CCN(CC1)C(=O)C2=CC=CC=C2)/C=C/C3=CC=CN=C3",3.269,3,1,8]
["S2803","Galeterone","d5","L6200-08","in 10mM DMSO","Androgen Receptor,P450 (e.g. CYP17)","Endocrinology & Hormones","Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.",388.55,"851983-85-2",{"v":24,"d":"24.00"},61.77,"<1","N/A","http://selleckchem.com/products/galeterone-tok-001.html","C26H32N2O","free base","TOK-001","CC12CCC(O)CC1=CCC3C2CCC4(C)C3CC=C4[N]5C=NC6=C5C=CC=C6",4.897,1,1,1]
["S2804","Sirtinol","e5","L6200-08","in 10mM DMSO","Sirtuin","Epigenetics","Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.",394.47,"410536-97-9",{"v":23,"d":"23.00"},58.31,"<1","N/A","http://selleckchem.com/products/sirtinol.html","C26H22N2O2","free base","N/A","CC(NC(=O)C1=CC=CC=C1N=CC2=C3C=CC=CC3=CC=C2O)C4=CC=CC=C4",5.262,2,2,5]
["S2806","CEP-33779","f5","L6200-08","in 10mM DMSO","JAK","JAK/STAT","CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM, >40- and >800-fold versus JAK1 and TYK2.",462.57,"1257704-57-6",{"v":36,"d":"36.00"},77.83,"<1","N/A","http://selleckchem.com/products/cep33779.html","C24H26N6O2S","free base","N/A","CN1CCN(CC1)C2=CC=CC(=C2)NC3=N[N]4C=CC=C(C5=CC=C(C=C5)[S](C)(=O)=O)C4=N3",{"v":3.86,"d":"3.860"},4,1,5]
["S2808","Ipatasertib (GDC-0068)","g5","L6200-08","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Ipatasertib (GDC-0068, RG7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.",{"v":458,"d":"458.00"},"1001264-89-6",{"v":92,"d":"92.00"},200.87,"<1","N/A","http://selleckchem.com/products/gdc-0068.html","C24H32ClN5O2","free base","RG7440","CC(C)NCC(C(=O)N1CCN(CC1)C2=C3C(C)CC(O)C3=NC=N2)C4=CC=C(Cl)C=C4",3.102,3,2,6]
["S2811","Sapanisertib (MLN0128)","h5","L6200-08","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.",309.33,"1224844-38-5",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://selleckchem.com/products/ink128.html","C15H15N7O","free base","INK 128,TAK-228","CC(C)[N]1N=C(C2=CC3=C(OC(=N3)N)C=C2)C4=C(N)N=CN=C14",1.886,5,2,2]
["S2812","(R)-(-)-Gossypol acetic acid","a6","L6200-08","in 10mM DMSO","Apoptosis related,Autophagy,Bcl-2","Apoptosis","(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.",578.61,"866541-93-7",{"v":116,"d":"116.00"},200.48,"<1","N/A","https://www.selleckchem.com/products/at101-acetic-acid.html","C30H30O8.C2H4O2","free base","AT-101 acetic acid, (-)-Gossypol acetic acid, (R)-Gossypol acetic acid","CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(C)C=C4C(=C(O)C(=C(C=O)C4=C3O)O)C(C)C)O.CC(O)=O",6.388,3,6,5]
["S2814","Alpelisib (BYL719)","b6","L6200-08","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.",441.47,"1217486-61-7",{"v":88,"d":"88.00"},199.33,"<1","N/A","http://selleckchem.com/products/byl719.html","C19H22F3N5O2S","free base","N/A","CC1=C(SC(=N1)NC(=O)N2CCCC2C(N)=O)C3=CC(=NC=C3)C(C)(C)C(F)(F)F",2.826,4,2,5]
["S2817","Torin 2","c6","L6200-08","in 10mM DMSO","Apoptosis related,ATM/ATR,Autophagy,DNA-PK,mTOR","PI3K/Akt/mTOR","Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.",{"v":432.4,"d":"432.40"},"1223001-51-1",{"v":20,"d":"20.00"},46.25,"<1","N/A","http://selleckchem.com/products/torin-2.html","C24H15F3N4O","free base","N/A","NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(=O)C=C4)C5=CC=CC(=C5)C(F)(F)F)C3=C2",4.323,3,1,3]
["S2818","Tacedinaline (CI994)","d6","L6200-08","in 10mM DMSO","HDAC","Epigenetics","Tacedinaline (CI994, PD-123654, GOE-5549, Acetyldinaline) is a selective class I HDAC inhibitor with IC50 of 0.9, 0.9, 1.2, and >20 μM for human HDAC 1, 2, 3, and 8, respectively. Phase 3.",{"v":269.3,"d":"269.30"},"112522-64-2",{"v":54,"d":"54.00"},200.52,"<1","N/A","http://selleckchem.com/products/ci994-tacedinaline.html","C15H15N3O2","free base","PD-123654, GOE-5549, Acetyldinaline","CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N)C=CC=C2",0.988,2,3,3]
["S2820","TAE226 (NVP-TAE226)","e6","L6200-08","in 10mM DMSO","Apoptosis related,FAK,Pyk2","Angiogenesis","TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. TAE226 (NVP-TAE226) induces apoptosis.",468.94,"761437-28-9",{"v":94,"d":"94.00"},200.45,"<1","N/A","http://selleckchem.com/products/nvp-tae226.html","C23H25ClN6O3","free base","N/A","CNC(=O)C1=C(NC2=C(Cl)C=NC(=N2)NC3=C(OC)C=C(C=C3)N4CCOCC4)C=CC=C1",3.917,5,3,7]
["S2821","RG108","f6","L6200-08","in 10mM DMSO","DNA Methyltransferase","Epigenetics","RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.",334.33,"48208-26-0",{"v":67,"d":"67.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/rg108.html","C19H14N2O4","free base","N-Phthalyl-L-tryptophan","OC(=O)C(CC1=C[NH]C2=C1C=CC=C2)N3C(=O)C4=CC=CC=C4C3=O",2.677,3,1,4]
["S2823","Tideglusib (NP031112)","g6","L6200-08","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.",334.39,"865854-05-3",{"v":8,"d":"8.00"},23.92,"<1","N/A","http://selleckchem.com/products/tideglusib.html","C19H14N2O2S","free base","NP-12","O=C1SN(C(=O)N1CC2=CC=CC=C2)C3=C4C=CC=CC4=CC=C3",{"v":4.63,"d":"4.630"},2,0,3]
["S2824","TPCA-1","h6","L6200-08","in 10mM DMSO","Apoptosis related,IκB/IKK,NF-κB,STAT","NF-κB","TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.",279.29,"507475-17-4",{"v":56,"d":"56.00"},200.51,"<1","N/A","http://selleckchem.com/products/tpca-1.html","C12H10FN3O2S","free base","GW683965","NC(=O)NC1=C(C=C(S1)C2=CC=C(F)C=C2)C(N)=O",1.544,2,3,3]
["S2843","BI-D1870","a7","L6200-08","in 10mM DMSO","Autophagy,ROS,S6 Kinase","PI3K/Akt/mTOR","BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.",391.42,"501437-28-1",{"v":78,"d":"78.00"},199.27,"<1","N/A","http://selleckchem.com/products/bi-d1870.html","C19H23F2N5O2","free base","N/A","CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2",4.069,3,2,5]
["S2847","Cathepsin Inhibitor 1","b7","L6200-08","in 10mM DMSO","Cathepsin B,Cysteine Protease","Proteases","Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.",401.89,"225120-65-0",{"v":80,"d":"80.00"},199.06,"<1","N/A","http://selleckchem.com/products/cathepsin-Inhibitor-1.html","C20H24ClN5O2","free base","N/A","C[N]1N=C(C=C1C(=O)NC(CC2=CC=CC(=C2)Cl)C(=O)NCC#N)C(C)(C)C",3.303,3,2,7]
["S2851","Baricitinib (INCB028050)","c7","L6200-08","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.",371.42,"1187594-09-7",{"v":74,"d":"74.00"},199.24,"<1","N/A","http://selleckchem.com/products/baricitinib-ly3009104.html","C16H17N7O2S","free base","LY3009104","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":0.36,"d":"0.360"},5,1,5]
["S2853","Carfilzomib (PR-171)","d7","L6200-08","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,Proteasome","Proteases","Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.",719.91,"868540-17-4",{"v":50,"d":"50.00"},69.45,"<1","N/A","http://selleckchem.com/products/carfilzomib-pr-171.html","C40H57N5O7","free base","N/A","CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)C4(C)CO4",3.799,7,4,20]
["S2858","StemRegenin 1 (SR1)","e7","L6200-08","in 10mM DMSO","AhR","Metabolism","StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.",429.54,"1227633-49-9",{"v":86,"d":"86.00"},200.21,"<1","N/A","http://selleckchem.com/products/stemRegenin-1.html","C24H23N5OS","free base","N/A","CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=CC=C(O)C=C3)C4=CSC5=CC=CC=C45",{"v":5.19,"d":"5.190"},3,2,6]
["S2863","Nodinitib-1","f7","L6200-08","in 10mM DMSO","NOD","NF-κB","Nodinitib-1(ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.",287.34,"799264-47-4",{"v":57,"d":"57.00"},198.37,"<1","N/A","http://selleckchem.com/products/ml130.html","C14H13N3O2S","free base","ML130","CC1=CC=C(C=C1)[S](=O)(=O)[N]2C(=NC3=CC=CC=C23)N",2.984,3,1,2]
["S2864","IMD 0354","g7","L6200-08","in 10mM DMSO","IκB/IKK","NF-κB","IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.",383.67,"978-62-1",{"v":10,"d":"10.00"},26.06,"<1","N/A","http://selleckchem.com/products/imd-0354.html","C15H8ClF6NO2","free base","IKK2 Inhibitor V","OC1=C(C=C(Cl)C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F",4.921,1,2,4]
["S2866","U-104","h7","L6200-08","in 10mM DMSO","Carbonic Anhydrase","Metabolism","U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.",309.32,"178606-66-1",{"v":62,"d":"62.00"},200.44,"<1","N/A","http://selleckchem.com/products/u-104.html","C13H12FN3O3S","free base","MST-104, NSC 213841, SLC-0111, WBI-5111","N[S](=O)(=O)C1=CC=C(NC(=O)NC2=CC=C(F)C=C2)C=C1",1.433,3,3,3]
["S2867","WHI-P154","a8","L6200-08","in 10mM DMSO","EGFR,JAK","JAK/STAT","WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.",{"v":376.2,"d":"376.20"},"211555-04-3",{"v":75,"d":"75.00"},199.36,"<1","N/A","http://selleckchem.com/products/whi-p154.html","C16H14BrN3O3","free base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC=C(O)C(=C3)Br",{"v":3.95,"d":"3.950"},4,2,4]
["S2868","Alogliptin (SYR-322) benzoate","b8","L6200-08","in 10mM DMSO","DPP","Proteases","Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.",461.51,"850649-62-6",{"v":68,"d":"68.00"},147.34,{"v":2,"d":"2.00"},4.33,"http://selleckchem.com/products/alogliptin-syr-322.html","C18H21N5O2.C7H6O2","benzoate","SYR-322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S2871","T0070907","c8","L6200-08","in 10mM DMSO","DNA-PK,PPAR,RAD51","DNA Damage/DNA Repair","T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM in a cell-free assay, with a >800-fold selectivity over PPARα and PPARδ. T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.",277.66,"313516-66-4",{"v":26,"d":"26.00"},93.64,"<1","N/A","http://selleckchem.com/products/t0070907.html","C12H8ClN3O3","free base","N/A","[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC2=CC=NC=C2",2.022,2,1,3]
["S2874","Camostat Mesilate","d8","L6200-08","in 10mM DMSO","COVID-19,Sodium Channel","Transmembrane Transporters","Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.",494.52,"59721-29-8",{"v":99,"d":"99.00"},200.19,{"v":10,"d":"10.00"},20.22,"http://selleckchem.com/products/camostat-mesilate-foy-305.html","C20H22N4O5.CH4O3S","Mesilate","FOY-305, FOY-S980","CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=N)C=C2)C=C1.C[S](O)(=O)=O",0.969,5,2,10]
["S2882","IKK-16 (IKK Inhibitor VII)","e8","L6200-08","in 10mM DMSO","IκB/IKK,LRRK2","NF-κB","IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.",483.63,"873225-46-8",{"v":97,"d":"97.00"},200.57,"<1","N/A","http://selleckchem.com/products/ikk-16.html","C28H29N5OS","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC=C(NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5)C=C3",5.208,3,1,5]
["S2898","MLN0905","f8","L6200-08","in 10mM DMSO","PLK","Cell Cycle","MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM.",486.56,"1228960-69-7",{"v":97,"d":"97.00"},199.36,"<1","N/A","http://selleckchem.com/products/mln0905.html","C24H25F3N6S","free base","N/A","CN(C)CCCC1=CC(=C(C)N=C1)NC2=NC3=C(CC(=S)NC4=CC(=CC=C34)C(F)(F)F)C=N2",5.355,3,2,7]
["S2902","S-Ruxolitinib (INCB018424)","g8","L6200-08","in 10mM DMSO","JAK","JAK/STAT","S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.",306.37,"941685-37-6",{"v":61,"d":"61.00"},199.11,{"v":5,"d":"5.00"},16.32,"http://selleckchem.com/products/s-ruxolitinib.html","C17H18N6","free base","N/A","N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",{"v":2.88,"d":"2.880"},3,1,4]
["S2903","Lumiracoxib","h8","L6200-08","in 10mM DMSO","COX","Neuronal Signaling","Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of  0.06 μM. It also inhibits COX1 with Ki of 3 μM.",293.72,"220991-20-8",{"v":59,"d":"59.00"},200.87,"<1","N/A","http://selleckchem.com/products/lumiracoxib-cox-189.html","C15H13ClFNO2","free base","COX-189","CC1=CC=C(NC2=C(Cl)C=CC=C2F)C(=C1)CC(O)=O",{"v":4.4,"d":"4.400"},1,1,4]
["S2907","Pirfenidone (S-7701)","a9","L6200-08","in 10mM DMSO","CCR,TGF-beta/Smad","TGF-beta/Smad","Pirfenidone (S-7701, AMR-69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties. Pirfenidone attenuates chemokine (CC motif) ligand-2 (CCL2) and CCL12 production with anti-fibrotic activity. Phase 3.",185.22,"53179-13-8",{"v":37,"d":"37.00"},199.76,"<1","N/A","http://selleckchem.com/products/pirfenidone.html","C12H11NO","free base","AMR-69","CC1=CN(C(=O)C=C1)C2=CC=CC=C2",1.905,1,0,1]
["S2910","Tempol","b9","L6200-08","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.",172.24,"2226-96-2",{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},{"v":34,"d":"34.00"},{"v":197.4,"d":"197.40"},"http://selleckchem.com/products/tempol-4-hydroxy-tempo.html","C9H18NO2","free base","4-Hydroxy-TEMPO","CC1(C)CC(O)CC(C)(C)N1[O]",0.413,0,1,0]
["S2911","Go 6983","c9","L6200-08","in 10mM DMSO","PKC","TGF-beta/Smad","Go 6983 (GOE 6983, Gö 6983) is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.",442.51,"133053-19-7",{"v":59,"d":"59.00"},133.33,"<1","N/A","http://selleckchem.com/products/go-6983.html","C26H26N4O3","free base","GOE 6983, Gö 6983","COC1=CC=C2[N](CCCN(C)C)C=C(C2=C1)C3=C(C(=O)NC3=O)C4=C[NH]C5=C4C=CC=C5",{"v":3.54,"d":"3.540"},3,2,7]
["S2913","BAY 11-7082","d9","L6200-08","in 10mM DMSO","Apoptosis related,DUB,IκB/IKK","NF-κB","BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.",207.25,"19542-67-7",{"v":41,"d":"41.00"},197.83,"<1","N/A","http://selleckchem.com/products/bay-11-7082-bay-11-7821.html","C10H9NO2S","free base","BAY 11-7821","CC1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",1.721,2,0,2]
["S2914","Dapivirine (TMC120)","e9","L6200-08","in 10mM DMSO","Reverse Transcriptase","Microbiology","Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.",{"v":329.4,"d":"329.40"},"244767-67-7",{"v":34,"d":"34.00"},103.22,"<1","N/A","http://selleckchem.com/products/dapivirine.html","C20H19N5","free base","N/A","CC1=CC(=C(NC2=CC=NC(=N2)NC3=CC=C(C=C3)C#N)C(=C1)C)C",5.549,2,2,4]
["S2915","GW9662","f9","L6200-08","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM in a cell-free assay, with at least 10- to 600-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.",276.68,"22978-25-2",{"v":55,"d":"55.00"},198.79,"<1","N/A","http://selleckchem.com/products/gw9662.html","C13H9ClN2O3","free base","TIMTEC-BB SBB006523","[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC2=CC=CC=C2",3.173,1,1,3]
["S2919","IOX2","g9","L6200-08","in 10mM DMSO","HIF","Angiogenesis","IOX2 (JICL38) is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.",352.34,"931398-72-0",{"v":7,"d":"7.00"},19.87,"<1","N/A","http://selleckchem.com/products/iox2.html","C19H16N2O5","free base","JICL38","OC(=O)CNC(=O)C1=C(O)C2=C(C=CC=C2)N(CC3=CC=CC=C3)C1=O",1.153,3,2,5]
["S2924","Laduviglusib (CHIR-99021) HCl","h9","L6200-08","in 10mM DMSO","Autophagy,GSK-3,Wnt/beta-catenin","PI3K/Akt/mTOR","Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.",{"v":501.8,"d":"501.80"},"1797989-42-4",{"v":93,"d":"93.00"},185.33,"<1","N/A","http://selleckchem.com/products/chir-99021-ct99021-hcl.html","C22H18Cl2N8.HCl","Hydrochloride","CT99021 HCl","Cl.CC1=C[NH]C(=N1)C2=CN=C(NCCNC3=NC=C(C=C3)C#N)N=C2C4=CC=C(Cl)C=C4Cl",4.858,4,3,7]
["S2926","TDZD-8","a10","L6200-08","in 10mM DMSO","COVID-19,GSK-3","PI3K/Akt/mTOR","TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.",222.26,"327036-89-5",{"v":44.5,"d":"44.50"},200.22,"<1","N/A","http://selleckchem.com/products/tdzd-8.html","C10H10N2O2S","free base","NP 01139","CN1SC(=O)N(CC2=CC=CC=C2)C1=O",2.145,2,0,2]
["S2928","TAK-715","b10","L6200-08","in 10mM DMSO","p38 MAPK","MAPK","TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Phase 2.",399.51,"303162-79-0",{"v":80,"d":"80.00"},200.25,"<1","N/A","http://selleckchem.com/products/tak-715.html","C24H21N3OS","free base","N/A","CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C",5.629,3,1,5]
["S2929","Pifithrin-α (PFTα) HBr","c10","L6200-08","in 10mM DMSO","AhR,Autophagy,p53","Apoptosis","Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).",{"v":367.3,"d":"367.30"},"63208-82-2",{"v":67,"d":"67.00"},182.41,"<1","N/A","http://selleckchem.com/products/pifithrin-alpha.html","C16H18N2OS.HBr","HBr","Pifithrin-α hydrobromide","Br.CC1=CC=C(C=C1)C(=O)CN2C(=N)SC3=C2CCCC3",3.993,1,0,3]
["S2930","Pifithrin-μ","d10","L6200-08","in 10mM DMSO","Autophagy,HSP (HSP90),p53","Apoptosis","Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.",181.21,"64984-31-2",{"v":36,"d":"36.00"},198.66,"<1","N/A","http://selleckchem.com/products/pifithrin-u.html","C8H7NO2S","free base","NSC 303580, PFTμ, 2-Phenylethynesulfonamide","N[S](=O)(=O)C#CC1=CC=CC=C1",0.825,2,1,2]
["S3001","Clevudine","e10","L6200-08","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Clevudine(Levovir,L-FMAU) is an antiviral drug for the treatment of hepatitis B.",260.22,"163252-36-6",{"v":52,"d":"52.00"},199.83,{"v":52,"d":"52.00"},199.83,"http://selleckchem.com/products/clevudine-levovir.html","C10H13FN2O5","free base","Levovir,L-FMAU","CC1=CN(C2OC(CO)C(O)C2F)C(=O)NC1=O",-1.065,3,3,2]
["S3002","Rivaroxaban (BAY 59-7939)","f10","L6200-08","in 10mM DMSO","Factor Xa","Metabolism","Rivaroxaban (BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays, respectively. It is selective for human factor Xa, for which it has >10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20 μM).",435.88,"366789-02-8",{"v":87,"d":"87.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/Rivaroxaban.html","C19H18ClN3O5S","free base","BAY 59-7939","ClC1=CC=C(S1)C(=O)NCC2CN(C(=O)O2)C3=CC=C(C=C3)N4CCOCC4=O",1.797,5,1,5]
["S3005","Paroxetine HCl","g10","L6200-08","in 10mM DMSO","Serotonin Transporter","Neuronal Signaling","Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.",365.83,"78246-49-8",{"v":73,"d":"73.00"},199.55,{"v":1,"d":"1.00"},2.73,"http://selleckchem.com/products/paroxetine-hcl.html","C19H20FNO3.HCl","Hydrochloride","BRL-29060A, FG-7051","Cl.FC1=CC=C(C=C1)C2CCNCC2COC3=CC4=C(OCO4)C=C3",3.611,3,1,4]
["S3008","Zaltoprofen","h10","L6200-08","in 10mM DMSO","COX","Neuronal Signaling","Zaltoprofen(CN100,Soleton) is an inhibitor of COX-1 and COX-2 for treatment of arthritis.",298.36,"74711-43-6",{"v":60,"d":"60.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://selleckchem.com/products/zaltoprofen.html","C17H14O3S","free base","CN100,Soleton","CC(C(O)=O)C1=CC2=C(SC3=CC=CC=C3C(=O)C2)C=C1",3.684,2,0,2]
["S3012","Pazopanib","a11","L6200-08","in 10mM DMSO","Autophagy,Cathepsin B,c-Kit,CSF-1R,Cysteine Protease,FGFR,PDGFR,VEGFR","Protein Tyrosine Kinase","Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.",437.52,"444731-52-6",{"v":87,"d":"87.00"},198.85,"<1","N/A","http://selleckchem.com/products/pazopanib.html","C21H23N7O2S","Free Base","GW786034","C[N]1N=C2C=C(C=CC2=C1C)N(C)C3=NC(=NC=C3)NC4=CC=C(C)C(=C4)[S](N)(=O)=O",3.741,5,2,5]
["S3017","Aspirin (NSC 27223)","b11","L6200-08","in 10mM DMSO","Autophagy,COX,Mitophagy","Metabolism","Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.",180.16,"50-78-2",{"v":36,"d":"36.00"},199.82,"<1","N/A","http://selleckchem.com/products/aspirin-acetylsalicylic-acid.html","C9H8O4","free base","Acetylsalicylic acid, ASA","CC(=O)OC1=C(C=CC=C1)C(O)=O",1.227,3,0,3]
["S3018","Niflumic acid","c11","L6200-08","in 10mM DMSO","COX,GABA Receptor","Neuronal Signaling","Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.",282.22,"4394-00-7",{"v":56,"d":"56.00"},198.43,"<1","N/A","http://selleckchem.com/products/niflumic-acid.html","C13H9F3N2O2","free base","Nifluril","OC(=O)C1=CC=CN=C1NC2=CC=CC(=C2)C(F)(F)F",{"v":3.34,"d":"3.340"},2,1,4]
["S3022","Cabazitaxel (XRP6258)","d11","L6200-08","in 10mM DMSO","Autophagy,Microtubule Associated","Cytoskeletal Signaling","Cabazitaxel (RPR-116258A, XRP6258, TXD 258, Taxoid XRP6258) is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Cabazitaxel induces autophagy via the PI3K/Akt/mTOR pathway.",835.93,"183133-96-2",{"v":100,"d":"100.00"},119.63,"<1","N/A","http://selleckchem.com/products/cabazitaxel-jevtana.html","C45H57NO14","free base","RPR-116258A, TXD 258, Taxoid XRP6258","COC1CC2OCC2(OC(C)=O)C3C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(OC)C(=O)C13C)C5(C)C)C",3.403,12,2,15]
["S3023","Bufexamac","e11","L6200-08","in 10mM DMSO","COX,IFN","Neuronal Signaling","Bufexamac(Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.",223.27,"2438-72-4",{"v":45,"d":"45.00"},201.55,"<1","N/A","http://selleckchem.com/products/bufexamac.html","C12H17NO3","free base","Bufexamic acid","CCCCOC1=CC=C(CC(=O)NO)C=C1",2.191,2,1,6]
["S3024","Lamotrigine","f11","L6200-08","in 10mM DMSO","5-HT Receptor,Sodium Channel","Transmembrane Transporters","Lamotrigine (BW-430C,LTG) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.",256.09,"84057-84-1",{"v":10,"d":"10.00"},39.05,"<1","N/A","http://selleckchem.com/products/lamotrigine.html","C9H7Cl2N5","free base","BW-430C,LTG","NC1=NC(=C(N=N1)C2=CC=CC(=C2Cl)Cl)N",2.426,3,2,1]
["S3025","PMSF","g11","L6200-08","in 10mM DMSO","Cysteine Protease,Serine Protease","Proteases","PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.",174.19,"329-98-6",{"v":35,"d":"35.00"},200.93,"<1","N/A","http://selleckchem.com/products/pmsf-phenylmethylsulfonyl-fluoride.html","C7H7FO2S","free base","Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride","F[S](=O)(=O)CC1=CC=CC=C1",1.459,2,0,2]
["S3026","Piceatannol","h11","L6200-08","in 10mM DMSO","Arginase,Syk","Angiogenesis","Piceatannol, a natural stilbene, is a selective Syk inhibitor and ~10-fold selectivity versus Lyn.",244.24,"10083-24-6",{"v":48,"d":"48.00"},196.53,"<1","N/A","http://selleckchem.com/products/piceatannol.html","C14H12O4","free base","N/A","OC1=CC(=CC(=C1)/C=C/C2=CC=C(O)C(=C2)O)O",2.848,0,4,2]
["S3027","Fenoprofen calcium hydrate","a2","L6200-09","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fenoprofen calcium hydrate(Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate) is a non-steroidal anti-inflammatory drug (NSAID).",558.63,"71720-56-4, 53746-45-5",{"v":48,"d":"48.00"},85.92,"<1","N/A","http://selleckchem.com/products/fenoprofen-calcium-hydrate.html","C30H30CaO8","Calcium dihydrate salt","Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate","O.O.CC(C(=O)O[Ca]OC(=O)C(C)C1=CC=CC(=C1)OC2=CC=CC=C2)C3=CC=CC(=C3)OC4=CC=CC=C4",6.802,6,0,12]
["S3030","Niclosamide (BAY2353)","b2","L6200-09","in 10mM DMSO","Autophagy,STAT","JAK/STAT","Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).",327.12,"50-65-7",{"v":8,"d":"8.00"},24.46,"<1","N/A","http://www.selleck.cn/products/niclosamide-niclocide.html","C13H8Cl2N2O4","Free Base","Niclocide, NSC 178296","OC1=CC=C(Cl)C=C1C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.595,1,2,3]
["S3031","Linagliptin (BI-1356)","c2","L6200-09","in 10mM DMSO","Autophagy,Ferroptosis","Proteases","Linagliptin (BI-1356,GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.",472.54,"668270-12-0",{"v":17,"d":"17.00"},35.98,"<1","N/A","http://selleckchem.com/products/linagliptin-bi-1356.html","C25H28N8O2","free base","GSK2118436","CC#CC[N]1C(=NC2=C1C(=O)N(CC3=NC4=CC=CC=C4C(=N3)C)C(=O)N2C)N5CCCC(N)C5",2.718,5,1,5]
["S3033","Vildagliptin (LAF-237)","d2","L6200-09","in 10mM DMSO","DPP","Proteases","Vildagliptin (LAF-237,NVP-LAF 237) inhibits DPP−4 with IC50 of 2.3 nM.",{"v":303.4,"d":"303.40"},"274901-16-5",{"v":60,"d":"60.00"},197.76,{"v":60,"d":"60.00"},197.76,"http://selleckchem.com/products/vildagliptin-laf-237.html","C17H25N3O2","free base","NVP-LAF 237","O[C]12CC3[CH2]C(C1)C[C](C3)(C2)NCC(=O)N4CCCC4C#N",0.179,1,1,3]
["S3035","Daunorubicin (RP 13057) HCl","e2","L6200-09","in 10mM DMSO","ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,COVID-19,DNA/RNA Synthesis,Topoisomerase","DNA Damage/DNA Repair","Daunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis.",563.98,"23541-50-6",{"v":100,"d":"100.00"},177.31,{"v":100,"d":"100.00"},177.31,"http://selleckchem.com/products/daunorubicin-hcl-daunomycin-hcl.html","C27H29NO10.HCl","Hydrochloride","Daunomycin HCl, Rubidomycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(C)=O)O)C(=O)C2=CC=C1",{"v":1.01,"d":"1.010"},6,4,4]
["S3043","Rofecoxib","f2","L6200-09","in 10mM DMSO","COX","Neuronal Signaling","Rofecoxib (MK-0966) is a COX-2 inhibitor with IC50 of 18 nM.",314.36,"162011-90-7",{"v":63,"d":"63.00"},200.41,"<1","N/A","http://selleckchem.com/products/rofecoxib-vioxx.html","C17H14O4S","free base","MK-0966","C[S](=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3",2.871,4,0,3]
["S3052","Rupatadine Fumarate","g2","L6200-09","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively.",532.03,"182349-12-8",{"v":9,"d":"9.00"},16.92,"<1","N/A","http://selleckchem.com/products/rupatadine-fumarate.html","C26H26ClN3.C4H4O4","Fumarate","N/A","CC1=CN=CC(=C1)CN2CCC(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C35.OC(=O)\\C=C\\C(O)=O",2.672,4,0,4]
["S3062","Diclofenac Potassium","h2","L6200-09","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.",334.24,"15307-81-0",{"v":69,"d":"69.00"},206.44,{"v":10,"d":"10.00"},29.92,"http://selleckchem.com/products/diclofenac-potassium.html","C14H10Cl2KNO2","Potassium","CGP-45840B","[K+].[O-]C(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl",2.899,0,1,4]
["S3063","Diclofenac Diethylamine","a3","L6200-09","in 10mM DMSO","COX","Neuronal Signaling","Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.",369.29,"78213-16-8",{"v":74,"d":"74.00"},200.38,"<1","N/A","http://selleckchem.com/products/diclofenac-diethylamine.html","C14H11Cl2NO2.C4H11N","Diethylamine","N/A","CCNCC.OC(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl",{"v":2.15,"d":"2.150"},1,2,6]
["S3077","Tazobactam","b3","L6200-09","in 10mM DMSO","Selection Antibiotics for Transfected Cell,β-lactamase","Microbiology","Tazobactam (Tazobactam acid, Tazobactamum) is a β-lactamases Inhibitor with antibacterial activity. It also inhibits the class D oxacillinase OXA-2. It is used in combination with piperacillin and other β-lactam antibiotics to broaden their spectrum and enhance their effect.",300.29,"89786-04-9",{"v":60,"d":"60.00"},199.81,"<1","N/A","http://selleckchem.com/products/tazobactam.html","C10H12N4O5S","free base","Tazobactam acid, Tazobactamum","CC1(C[N]2C=CN=N2)C(N3C(CC3=O)[S]1(=O)=O)C(O)=O",-1.189,6,0,3]
["S3079","Atovaquone","c3","L6200-09","in 10mM DMSO","COVID-19,Fungal,Parasite","Microbiology","Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.",366.84,"95233-18-4",{"v":5,"d":"5.00"},13.63,"<1","N/A","http://selleckchem.com/products/atovaquone-atavaquone.html","C22H19ClO3","free base","Atavaquone","OC1=C(C2CCC(CC2)C3=CC=C(Cl)C=C3)C(=O)C4=C(C=CC=C4)C1=O",5.319,2,1,2]
["S3113","Pyridoxine HCl","d3","L6200-09","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine HCl (Vitamin B6,Pyridoxol hydrochloride) is a form of vitamin B6.",205.64,"58-56-0",{"v":41,"d":"41.00"},199.38,{"v":41,"d":"41.00"},199.38,"http://selleckchem.com/products/pyridoxine-hydrochloride.html","C8H11NO3.HCl","Hydrochloride","Vitamin B6,Pyridoxol hydrochloride","Cl.CC1=C(O)C(=C(CO)C=N1)CO",-0.108,1,3,2]
["S3114","Vitamin C","e3","L6200-09","in 10mM DMSO","Vitamin","Metabolism","Vitamin C (L-Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.",176.12,"50-81-7",{"v":35,"d":"35.00"},198.73,{"v":35,"d":"35.00"},198.73,"http://selleckchem.com/products/vitamin-c-ascorbic-acid.html","C6H8O6","free base","L-Ascorbic acid","OCC(O)C1OC(=O)C(=C1O)O",-1.709,2,4,2]
["S3120","Doxepin HCl","f3","L6200-09","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Doxepin is a tricyclic antidepressant formulated as a mixture of E-(trans) and Z-(cis) stereoisomers. It inhibits CYP2D6 activity in vivo.",315.84,"1229-29-4",{"v":63,"d":"63.00"},199.47,{"v":63,"d":"63.00"},199.47,"http://selleckchem.com/products/doxepin-hydrochloride-sinequan.html","C19H21NO.HCl","hydrochloride","N/A","Cl.CN(C)CC\\C=C1/C2=CC=CC=C2COC3=C1C=CC=C3",{"v":4.29,"d":"4.290"},1,0,3]
["S3124","Dexamethasone Acetate","g3","L6200-09","in 10mM DMSO","Complement System,COVID-19,IL Receptor","Immunology & Inflammation","Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":434.5,"d":"434.50"},"1177-87-3",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://selleckchem.com/products/dexamethasone-acetate.html","C24H31FO6","free base","NSC 39471,Dexamethasone 21-acetate","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COC(C)=O",2.087,4,1,4]
["S3129","Trimethoprim","h3","L6200-09","in 10mM DMSO","Antibiotics,Bacterial,DHFR","Microbiology","Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.",290.32,"738-70-5",{"v":58,"d":"58.00"},199.78,"<1","N/A","http://selleckchem.com/products/trimethoprim.html","C14H18N4O3","free base","BW 56-72, NIH 204, NSC-106568","COC1=C(OC)C(=CC(=C1)CC2=CN=C(N)N=C2N)OC",1.543,5,2,5]
["S3137","Sodium salicylate","a4","L6200-09","in 10mM DMSO","NF-κB","NF-κB","Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.",161.11,"54-21-7",{"v":32,"d":"32.00"},198.62,{"v":32,"d":"32.00"},198.62,"http://selleckchem.com/products/sodium-salicylate.html","C7H6O3.Na","sodium salt","2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt","[NaH].OC(=O)C1=CC=CC=C1O",1.217,1,1,1]
["S3138","Methylthiouracil","b4","L6200-09","in 10mM DMSO","ERK,Interleukins,NF-κB,TNF-alpha","NF-κB","Methylthiouracil (NSC-193526, NSC-9378,MTU) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.",142.18,"56-04-2",{"v":28,"d":"28.00"},196.93,"<1","N/A","http://selleckchem.com/products/methylthiouracil.html","C5H6N2OS","free base","NSC-193526, NSC-9378,MTU","CC1=CC(=O)NC(=S)N1",0.595,1,2,0]
["S3147","Entacapone","c4","L6200-09","in 10mM DMSO","COMT,Histone Methyltransferase","Epigenetics","Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.",305.29,"130929-57-6",{"v":61,"d":"61.00"},199.81,"<1","N/A","http://selleckchem.com/products/entacapone.html","C14H15N3O5","free base","OR-611","CCN(CC)C(=O)\\C(=C\\C1=CC(=C(O)C(=C1)O)[N+]([O-])=O)C#N",1.658,1,2,5]
["S3154","Butenafine HCl","d4","L6200-09","in 10mM DMSO","Fungal","Microbiology","Butenafine HCl (KP-363) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.",353.93,"101827-46-7",{"v":70,"d":"70.00"},197.78,"<1","N/A","http://selleckchem.com/products/butenafine-hydrochloride.html","C23H27N.HCl","HCl","KP-363","Cl.CN(CC1=CC=C(C=C1)C(C)(C)C)CC2=C3C=CC=CC3=CC=C2",6.177,0,0,5]
["S3173","Antipyrine","e4","L6200-09","in 10mM DMSO","COX","Neuronal Signaling","Antipyrine (Phenazone,Phenazon) is an analgesic and antipyretic agent; selective COX-3 inhibitor.",188.23,"60-80-0",{"v":38,"d":"38.00"},201.88,{"v":38,"d":"38.00"},201.88,"http://selleckchem.com/products/antipyrine.html","C11H12N2O","free base","Phenazone,Phenazon","CN1N(C(=O)C=C1C)C2=CC=CC=C2",1.218,1,0,1]
["S3178","Brinzolamide","f4","L6200-09","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.",383.51,"138890-62-7",{"v":77,"d":"77.00"},200.78,"<1","N/A","http://selleckchem.com/products/brinzolamide.html","C12H21N3O5S3","free base","AL-4862","CCNC1CN(CCCOC)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",-0.772,5,2,7]
["S3181","Flumequine","g4","L6200-09","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Flumequine(R-802) is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.",261.25,"42835-25-6",{"v":3,"d":"3.00"},11.48,"<1","N/A","http://selleckchem.com/products/flumequine.html","C14H12FNO3","free base","R-802","CC1CCC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2)F",{"v":2.27,"d":"2.270"},2,0,1]
["S3200","Triflusal","h4","L6200-09","in 10mM DMSO","COX","Immunology & Inflammation","Triflusal (UR1501) irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.",248.16,"322-79-2",{"v":50,"d":"50.00"},201.48,"<1","N/A","http://selleckchem.com/products/triflusal.html","C10H7F3O4","free base","UR1501","CC(=O)OC1=CC(=CC=C1C(O)=O)C(F)(F)F",2.169,3,0,4]
["S3600","Schisandrin B (Sch B)","a5","L6200-09","in 10mM DMSO","ATM/ATR,P-gp","PI3K/Akt/mTOR","Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.",400.46,"61281-37-6",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://selleckchem.com/products/schisandrin-b.html","C23H28O6","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C4OCOC4=C3OC",5.067,6,0,4]
["S3603","Betulinic acid","b5","L6200-09","in 10mM DMSO","NF-κB,Topoisomerase","DNA Damage/DNA Repair","Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Betulinic acid acts as a new activator of NF-kB.Phase 1/2.",{"v":456.7,"d":"456.70"},"472-15-1",{"v":20,"d":"20.00"},43.79,"<1","N/A","http://selleckchem.com/products/betulinic-acid.html","C30H48O3","free base","ALS-357, Lupatic acid, Betulic acid","CC(=C)C1CCC2(CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12)C(O)=O",6.546,1,1,2]
["S3604","Triptolide (PG490)","c5","L6200-09","in 10mM DMSO","ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-κB","NF-κB","Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.",{"v":360.4,"d":"360.40"},"38748-32-2",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/triptolide.html","C20H24O6","free base","NSC 163062","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2O",0.872,5,1,1]
["S3609","Berbamine dihydrochloride","d5","L6200-09","in 10mM DMSO","Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA, BBM) dihydrochloride, a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",681.65,"6078-17-7",{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},{"v":100,"d":"100.00"},{"v":146.7,"d":"146.70"},"http://selleckchem.com/products/berbamine-dihydrochloride.html","C37H40N2O6.2HCl","dihydrochloride","BA, BBM","Cl.Cl.COC1=CC2=C3C=C1OC4=C(OC)C(=CC5=C4C(CC6=CC(=C(O)C=C6)OC7=CC=C(CC3N(C)CC2)C=C7)N(C)CC5)OC",7.756,5,1,3]
["S3610","Cordycepin","e5","L6200-09","in 10mM DMSO","MMP","Proteases","Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities.",251.24,"73-03-0",{"v":50,"d":"50.00"},199.01,{"v":25,"d":"25.00"},99.51,"http://selleckchem.com/products/cordycepin.html","C10H13N5O3","free base","3'-Deoxyadenosine","NC1=NC=NC2=C1N=C[N]2C3OC(CO)CC3O",-1.308,4,3,2]
["S3611","(+)-Fangchinoline","f5","L6200-09","in 10mM DMSO","Others","Others","Fangchinoline ((+)-Limacine, Tetrandrine B, Hanfangichin B) is a phytochemical that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown to possess neuroprotective activity.",608.72,"436-77-1",{"v":40,"d":"40.00"},65.71,"<1","N/A","http://selleckchem.com/products/s-s-fangchinoline.html","C37H40N2O6","free base","(+)-Limacine, Tetrandrine B, Hanfangichin B","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C=C(OC6=C7C(CC(=C2)C=C1)N(C)CCC7=CC(=C6O)OC)C(=C5)OC)C=C3",6.992,5,1,3]
["S3612","Rosmarinic acid","g5","L6200-09","in 10mM DMSO","Complement System,IκB/IKK","NF-κB","Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.",360.31,"20283-92-5",{"v":72,"d":"72.00"},199.83,{"v":24,"d":"24.00"},66.61,"http://selleckchem.com/products/rosmarinic-acid.html","C18H16O8","free base","Rosemary acid","OC(=O)C(CC1=CC=C(O)C(=C1)O)OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O",2.706,3,4,7]
["S3613","Scoparone","h5","L6200-09","in 10mM DMSO","Others","Others","Scoparone (6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone) is a natural organic compound discovered from Chinese herb Artemisia scoparia with anticoagulant, hypolipidemic, vasorelaxant, antioxidant, and anti-inflammatory actions.",206.19,"120-08-1",{"v":41,"d":"41.00"},198.85,"<1","N/A","http://selleckchem.com/products/scoparone.html","C11H10O4","free base","6,7-dimethoxycoumarin, Aesculetin dimethyl ether, 6,7-Dimethylesculetin, Escoparone","COC1=CC2=C(C=CC(=O)O2)C=C1OC",1.866,4,0,2]
["S3615","Dehydrocostus Lactone","a6","L6200-09","in 10mM DMSO","IκB/IKK","NF-κB","Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.",{"v":230.3,"d":"230.30"},"477-43-0",{"v":46,"d":"46.00"},199.74,"<1","N/A","http://selleckchem.com/products/dehydrocostus-lactone.html","C15H18O2","free base","N/A","C=C1CCC2C(OC(=O)C2=C)C3C1CCC3=C",3.282,2,0,0]
["S3616","Asiaticoside","b6","L6200-09","in 10mM DMSO","ROS","Immunology & Inflammation","Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.",959.12,"16830-15-2",{"v":100,"d":"100.00"},104.26,"<1","N/A","http://selleckchem.com/products/asiaticoside.html","C48H78O19","free base","Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC34C)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O",-0.101,7,12,10]
["S3617","(20S)-Protopanaxatriol","c6","L6200-09","in 10mM DMSO","Estrogen/progestogen Receptor,Glucocorticoid Receptor","Endocrinology & Hormones","(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the glucocorticoid receptor (GR) and estrogen receptor (ER).",476.73,"34080-08-5",{"v":95,"d":"95.00"},199.27,"<1","N/A","http://selleckchem.com/products/20s-protopanaxatriol.html","C30H52O4","free base","g-PPT, 20(S)-APPT","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(O)CC23C",{"v":4.62,"d":"4.620"},0,3,4]
["S3624","Quinolinic acid","d6","L6200-09","in 10mM DMSO","NMDAR","Neuronal Signaling","Quinolinic Acid (pyridine-2,3-dicarboxylic acid, QUIN), a neuroactive metabolite of the kynurenine pathway, is an agonist of N-methyl-D-aspartate (NMDA) receptor.",167.12,"89-00-9",{"v":25,"d":"25.00"},149.59,{"v":3,"d":"3.00"},17.95,"http://selleckchem.com/products/quinolinic-acid.html","C7H5NO4","free base","pyridine-2,3-dicarboxylic acid, QUIN","OC(=O)C1=CC=CN=C1C(O)=O",0.367,3,0,2]
["S3626","Sesamol","e6","L6200-09","in 10mM DMSO","Antioxidant","Apoptosis","Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.",138.12,"533-31-3",{"v":27,"d":"27.00"},195.48,{"v":27,"d":"27.00"},195.48,"http://selleckchem.com/products/sesamol.html","C7H6O3","free base","1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol","OC1=CC2=C(OCO2)C=C1",1.356,2,1,0]
["S3628","BHQ","f6","L6200-09","in 10mM DMSO","ADC Cytotoxin,ATPase","Transmembrane Transporters","BHQ (2,5-di-t-butyl-1,4-benzohydroquinone) is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).",222.32,"88-58-4",{"v":10,"d":"10.00"},44.98,"<1","N/A","http://selleckchem.com/products/bhq.html","C14H22O2","free base","2,5-di-t-butyl-1,4-benzohydroquinone","CC(C)(C)C1=C(O)C=C(C(=C1)O)C(C)(C)C",4.146,0,2,2]
["S3629","Syringic acid","g6","L6200-09","in 10mM DMSO","Antioxidant","Angiogenesis","Syringic acid (NSC 2129, SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.",198.17,"530-57-4",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},{"v":1,"d":"1.00"},5.05,"http://selleckchem.com/products/syringic-acid.html","C9H10O5","free base","3,5-dimethyl ether Gallic Acid, 3,5-dimethoxy-4-hydroxy Benzoic Acid, NSC 2129, SYRA","COC1=CC(=CC(=C1O)OC)C(O)=O",1.184,3,1,3]
["S3630","Methyl Vanillate","h6","L6200-09","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.",182.17,"3943-74-6",{"v":36,"d":"36.00"},197.62,{"v":12,"d":"12.00"},65.87,"http://selleckchem.com/products/methyl-vanillate.html","C9H10O4","free base","N/A","COC(=O)C1=CC(=C(O)C=C1)OC",1.426,3,1,3]
["S3633","Pyrrolidinedithiocarbamate ammonium","a7","L6200-09","in 10mM DMSO","NF-κB","NF-κB","Pyrrolidinedithiocarbamate ammonium  (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.",164.29,"5108-96-3",{"v":32,"d":"32.00"},194.78,{"v":32,"d":"32.00"},194.78,"http://selleckchem.com/products/pyrrolidinedithiocarbamate-ammoniumammonium.html","C5H9NS2.H3N","ammonium salt","APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt","N.SC(=S)N1CCCC1",2.172,0,0,1]
["S3639","Tacrine hydrochloride hydrate","b7","L6200-09","in 10mM DMSO","AChR,HNMT","Neuronal Signaling","Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.","198.26(free bases)","206658-92-6",{"v":50,"d":"50.00"},252.19,{"v":50,"d":"50.00"},252.19,"http://selleckchem.com/products/tacrine-hydrochloride-hydrate.html","C13H14N2.xHCl.xH2O","hydrochloride hydrate","Tacrine, Tetrahydroaminacrine, Tetrahydroaminoacridine","NC1=C2C=CC=CC2=NC3=C1CCCC3",4.258,1,1,0]
["S3647","Mafenide Acetate","c7","L6200-09","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Mafenide Acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.",246.28,"13009-99-9",{"v":49,"d":"49.00"},198.96,{"v":49,"d":"49.00"},198.96,"http://selleckchem.com/products/mafenide-acetate.html","C7H10N2O2S.C2H4O2","acetate","N/A","CC(O)=O.NCC1=CC=C(C=C1)[S](N)(=O)=O",-3.043,3,2,2]
["S3648","Amlexanox (AA-673)","d7","L6200-09","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK,TBK1","Immunology & Inflammation","Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.",298.29,"68302-57-8",{"v":59,"d":"59.00"},197.79,"<1","N/A","http://selleckchem.com/products/amlexanox.html","C16H14N2O4","free base","CHX-3673, Amoxanox","CC(C)C1=CC2=C(OC3=NC(=C(C=C3C2=O)C(O)=O)N)C=C1",2.969,4,1,2]
["S3652","3-Nitropropionic acid","e7","L6200-09","in 10mM DMSO","Dehydrogenase","Metabolism","3-Nitropropionic acid (β-Nitropropionic Acid, 3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.",119.08,"504-88-1",{"v":23,"d":"23.00"},193.15,{"v":23,"d":"23.00"},193.15,"http://selleckchem.com/products/3-nitropropionic-acid.html","C3H5NO4","free base","β-Nitropropionic Acid, 3-NP","OC(=O)CC[N+]([O-])=O",{"v":0.02,"d":"0.020"},1,0,3]
["S3653","Spermidine trihydrochloride","f7","L6200-09","in 10mM DMSO","Autophagy,NMDAR","Neuronal Signaling","Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).",254.63,"334-50-9",{"v":30,"d":"30.00"},117.82,{"v":50,"d":"50.00"},196.36,"http://selleckchem.com/products/spermidine-trihydrochloride.html","C7H19N3.3HCl","trihydrochloride","4-Azaoctamethylenediamine trihydrochloride","Cl.Cl.Cl.NCCCCNCCCN",-0.024,0,3,7]
["S3654","Tauroursodeoxycholic Acid (TUDCA)","g7","L6200-09","in 10mM DMSO","Mitochondrial Metabolism","Neuronal Signaling","Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).",{"v":499.7,"d":"499.70"},"14605-22-2",{"v":99,"d":"99.00"},198.12,{"v":30,"d":"30.00"},60.04,"http://selleckchem.com/products/tauroursodeoxycholic-acid.html","C26H45NO6S","free base","N/A","CC(CCC(=O)NCC[S](O)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",2.997,1,3,7]
["S3658","O6-Benzylguanine","h7","L6200-09","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.",241.25,"19916-73-5",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/o6-benzylguanine.html","C12H11N5O","free base","O6-BG","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3=CC=CC=C3",1.646,4,2,3]
["S3659","Fludrocortisone acetate","a8","L6200-09","in 10mM DMSO","Others","Others","Fludrocortisone (9α-fluorocortisol) is a synthetic pregnane steroid and a halogenated derivative of cortisol. It is used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency.",422.49,"514-36-3",{"v":84,"d":"84.00"},198.82,"<1","N/A","http://selleckchem.com/products/fludrocortisone-acetate.html","C23H31FO6","free base","9α-fluorocortisol acetate","CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC12C",1.791,4,1,4]
["S3660","Uniconazole (S 3307D)","b8","L6200-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Uniconazole (S 3307D, XE 1019D) is a well known inhibitor of cytochrome P450 monooxygenase that prevents the biosynthesis of trans-zeatin. Uniconazole targets CYP735As with Ki of 22 μM.",291.78,"83657-22-1",{"v":58,"d":"58.00"},198.78,"<1","N/A","http://selleckchem.com/products/uniconazole.html","C15H18ClN3O","free base","XE 1019D","CC(C)(C)C(O)C(=C/C1=CC=C(Cl)C=C1)\\[N]2C=NC=N2",3.098,2,1,4]
["S3661","2-Methoxy-1,4-naphthoquinone","c8","L6200-09","in 10mM DMSO","PKC","Cytoskeletal Signaling","2-Methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera, specifically suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner in Raji cells.",188.18,"2348-82-5",{"v":37,"d":"37.00"},196.62,"<1","N/A","http://selleckchem.com/products/2-methoxy-1-4-naphthoquinone.html","C11H8O3","free base","N/A","COC1=CC(=O)C2=C(C=CC=C2)C1=O",1.445,3,0,1]
["S3665","Trolox","d8","L6200-09","in 10mM DMSO","Vitamin","Metabolism","Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.",250.29,"53188-07-1",{"v":50,"d":"50.00"},199.77,"<1","N/A","http://selleckchem.com/products/trolox.html","C14H18O4","free base","N/A","CC1=C(C)C2=C(CCC(C)(O2)C(O)=O)C(=C1O)C",3.489,2,1,1]
["S3666","Ilaprazole","e8","L6200-09","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) is a new proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.",366.44,"172152-36-2",{"v":73,"d":"73.00"},199.21,"<1","N/A","http://selleckchem.com/products/ilaprazole.html","C19H18N4O2S","free base","IY-81149","COC1=CC=NC(=C1C)C[S](=O)C2=NC3=C([NH]2)C=C(C=C3)[N]4C=CC=C4",3.311,4,1,5]
["S3669","Carmustine","f8","L6200-09","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Carmustine (bis-chloroethylnitrosourea, BCNU, BiCNU) is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.",214.05,"154-93-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carmustine.html","C5H9Cl2N3O2","free base","bis-chloroethylnitrosourea, BCNU, BiCNU","ClCCNC(=O)N(CCCl)N=O",1.201,2,1,5]
["S3671","Quinestrol","g8","L6200-09","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.",364.52,"152-43-2",{"v":72,"d":"72.00"},197.52,"<1","N/A","http://selleckchem.com/products/quinestrol.html","C25H32O2","free base","Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566","CC12CCC3C(CCC4=C3C=CC(=C4)OC5CCCC5)C1CCC2(O)C#C",6.514,1,0,2]
["S3673","Sulfaphenazole","h8","L6200-09","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Sulfaphenazole (Depocid, Depotsulfonamide, Plisulfan, Raziosulfa) is an inhibitor of CYP2C9 with Ki value of 0.3 μM and demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki values of 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).",314.36,"526-08-9",{"v":62,"d":"62.00"},197.23,"<1","N/A","http://selleckchem.com/products/sulfaphenazole.html","C15H14N4O2S","free base","Depocid, Depotsulfonamide, Plisulfan, Raziosulfa","NC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=N[N]2C3=CC=CC=C3",1.922,3,2,4]
["S3675","Umbelliferone","a9","L6200-09","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Umbelliferone (7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone) is a 7-hydroxycoumarin that is a pharmacologically active agent. It is a fluorescing compound used as a sunscreen agent and shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals with anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities.",162.14,"93-35-6",{"v":32,"d":"32.00"},197.36,"<1","N/A","http://selleckchem.com/products/umbelliferone.html","C9H6O3","free base","7-hydroxycoumarin, hydrangine, skimmetine, beta-umbelliferone","OC1=CC2=C(C=C1)C=CC(=O)O2",1.657,2,1,0]
["S3679","Flavanone","b9","L6200-09","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Flavanones (2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity, and appear to be associated with a reduced risk of certain chronic diseases, the prevention of some cardiovascular disorders, and certain kinds of cancer. Flavanones also exhibit antiviral, antimicrobial, and anti-inflammatory activities, beneficial effects on capillary fragility, and an ability to inhibit human platelet aggregation, anti-ulcer, and anti-allergenic properties.",224.25,"487-26-3",{"v":44,"d":"44.00"},196.21,"<1","N/A","http://selleckchem.com/products/flavanone.html","C15H12O2","free base","2,3-Dihydroflavone, 4-Flavanone, 2-Phenyl-4-chromanone, 2-Phenylchroman-4-one","O=C1CC(OC2=C1C=CC=C2)C3=CC=CC=C3",3.099,2,0,1]
["S3681","Vitamin E Acetate","c9","L6200-09","in 10mM DMSO","Vitamin","Metabolism","Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant., Vitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. ,",472.74,"58-95-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e-acetate.html","C31H52O3","free base","Tocopherol acetate","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)OC(C)=O",{"v":10.45,"d":"10.450"},3,0,14]
["S3688","2,4-Diamino-6-hydroxypyrimidine","d9","L6200-09","in 10mM DMSO","GTPCH","Metabolism","2,4-Diamino-6-hydroxypyrimidine (DAHP) is a specific inhibitor for GTP cyclohydrolase I, the rate-limiting enzyme in de novo pterin synthesis.",126.12,"56-06-4",{"v":25,"d":"25.00"},198.22,{"v":6,"d":"6.00"},47.57,"http://selleckchem.com/products/2-4-diamino-6-hydroxypyrimidine.html","C4H6N4O","free base","DAHP","NC1=CC(=NC(=N1)N)O",-0.085,2,3,0]
["S3690","Pargyline hydrochloride","e9","L6200-09","in 10mM DMSO","MAO","Metabolism","Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.",195.69,"306-07-0",{"v":39,"d":"39.00"},199.29,{"v":39,"d":"39.00"},199.29,"http://selleckchem.com/products/pargyline-hydrochloride.html","C11H13N.HCl","hydrochloride","Pargylamine hydrochloride","Cl.CN(CC#C)CC1=CC=CC=C1",3.477,0,0,3]
["S3692","N-Ethylmaleimide (NEM)","f9","L6200-09","in 10mM DMSO","Cysteine Protease,DUB","Proteases","N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.",125.13,"128-53-0",{"v":25,"d":"25.00"},199.79,{"v":25,"d":"25.00"},199.79,"http://selleckchem.com/products/n-ethylmaleimide-nem.html","C6H7NO2","free base","N/A","CCN1C(=O)C=CC1=O",{"v":0.16,"d":"0.160"},2,0,1]
["S3694","Glucosamine hydrochloride","g9","L6200-09","in 10mM DMSO","Others","Immunology & Inflammation","Glucosamine (2-Amino-2-deoxy-glucose, Chitosamine) is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, also presents in the shells of shellfish, animal bones, bone marrow, and fungi. Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.",215.63,"66-84-2",{"v":4,"d":"4.00"},18.55,{"v":43,"d":"43.00"},199.42,"http://selleckchem.com/products/glucosamine-hydrochloride.html","C6H13NO5.HCl","hydrochloride","2-Amino-2-deoxy-glucose HCl, Chitosamine HCl","Cl.NC1C(O)OC(CO)C(O)C1O",-2.422,1,4,1]
["S3697","Mafenide hydrochloride","h9","L6200-09","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Mafenide is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.",222.69,"138-37-4",{"v":44,"d":"44.00"},197.58,{"v":44,"d":"44.00"},197.58,"http://selleckchem.com/products/mafenide-hydrochloride.html","C7H10N2O2S.HCl","hydrochloride","4-Aminomethylbenzenesulfonamide hydrochloride","Cl.NCC1=CC=C(C=C1)[S](N)(=O)=O",0.023,2,2,2]
["S3698","Nortriptyline hydrochloride","a10","L6200-09","in 10mM DMSO","Autophagy","Autophagy","Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.",299.84,"894-71-3",{"v":59,"d":"59.00"},196.77,{"v":59,"d":"59.00"},196.77,"http://selleckchem.com/products/nortriptyline-hydrochloride.html","C19H21N.HCl","hydrochloride","Desitriptyline HCl, ELF-101 hydrochloride, EN-7048 hydrochloride, Desmethylamitriptyline hydrochloride","Cl.CNCCC=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.618,0,1,3]
["S3719","Topiroxostat","b10","L6200-09","in 10mM DMSO","P450 (e.g. CYP17),Xanthine Oxidase","Metabolism","Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.",248.24,"577778-58-6",{"v":40,"d":"40.00"},161.13,"<1","N/A","http://selleckchem.com/products/topiroxostat.html","C13H8N6","free base","N/A","N#CC1=NC=CC(=C1)C2=N[NH]C(=N2)C3=CC=NC=C3",1.141,4,1,2]
["S3720","Elafibranor","c10","L6200-09","in 10mM DMSO","PPAR","Metabolism","Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation.",384.49,"923978-27-2",{"v":76,"d":"76.00"},197.66,"<1","N/A","http://selleckchem.com/products/elafibranor.html","C22H24O4S","free base","GFT505","CSC1=CC=C(C=C1)C(=O)\\C=C\\C2=CC(=C(OC(C)(C)C(O)=O)C(=C2)C)C",5.477,3,0,7]
["S3722","Isavuconazole","d10","L6200-09","in 10mM DMSO","Fungal","Microbiology","Isavuconazole (BAL-4815, RO-0094815) is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis.",437.47,"241479-67-4",{"v":87,"d":"87.00"},198.87,"<1","N/A","http://selleckchem.com/products/isavuconazole.html","C22H17F2N5OS","free base","BAL-4815, RO-0094815","CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(O)(C[N]3C=NC=N3)C4=CC(=CC=C4F)F",3.904,3,0,6]
["S3724","Velpatasvir","e10","L6200-09","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Velpatasvir (GS-5816,VEL) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial \"membranous web\" that facilitates RNA replication.",{"v":883,"d":"883.00"},"1377049-84-7",{"v":100,"d":"100.00"},113.25,{"v":100,"d":"100.00"},113.25,"http://selleckchem.com/products/velpatasvir.html","C49H54N8O8","free base","GS-5816,VEL","COCC1CC(N(C1)C(=O)C(NC(=O)OC)C2=CC=CC=C2)C3=NC=C([NH]3)C4=CC=C5C(=C4)COC6=C5C=C7C=CC8=C(N=C([NH]8)C9CCC(C)N9C(=O)C(NC(=O)OC)C(C)C)C7=C6",5.789,10,4,13]
["S3725","ELR-510444","f10","L6200-09","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells.",368.47,"1233948-35-0",{"v":73,"d":"73.00"},198.12,"<1","N/A","http://selleckchem.com/products/elr-510444.html","C19H16N2O2S2","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=CC=C2C)C3=CC=C(S3)C#N",4.932,2,1,4]
["S3728","Grazoprevir","g10","L6200-09","in 10mM DMSO","HCV Protease","Proteases","Grazoprevir anhydrous (MK5172) is a Hepatitis C Virus NS3/4A Protease inhibitor with IC50 values of 7pM, 4pM, and 62pM for HCV genotype 1a, 1B, and 4 respectively.",{"v":766.9,"d":"766.90"},"1350514-68-9",{"v":100,"d":"100.00"},{"v":130.4,"d":"130.40"},"<1","N/A","http://selleckchem.com/products/grazoprevir.html","C38H50N6O9S","free base","MK5172","COC1=CC2=NC3=C(CCCCCC4CC4OC(=O)NC(C(=O)N5CC(CC5C(=O)NC6(CC6C=C)C(=O)N[S](=O)(=O)C7CC7)O3)C(C)(C)C)N=C2C=C1",3.975,11,3,8]
["S3731","Tipiracil hydrochloride","h10","L6200-09","in 10mM DMSO","Phosphorylase,Thymidylate Synthase","Metabolism","Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.",279.12,"183204-72-0",{"v":8,"d":"8.00"},28.66,{"v":55,"d":"55.00"},197.05,"http://selleckchem.com/products/tipiracil-hydrochloride.html","C9H11ClN4O2.HCl","hydrochloride","MA-1 hydrochloride","Cl.ClC1=C(CN2CCCC2=N)NC(=O)NC1=O",-0.388,2,2,2]
["S3733","Boceprevir","a11","L6200-09","in 10mM DMSO","COVID-19,HCV Protease","Proteases","Boceprevir (EBP 520, SCH 503034) is an oral, direct acting hepatitis C virus (HCV) protease inhibitor with Ki value of 14 nM for NS3. It is used in combination with other antiviral agents in the treatment of chronic hepatitis C, genotype 1.",519.68,"394730-60-0",{"v":100,"d":"100.00"},192.43,"<1","N/A","http://selleckchem.com/products/boceprevir.html","C27H45N5O5","free base","EBP 520, SCH 503034","CC(C)(C)NC(=O)NC(C(=O)N1CC2C(C1C(=O)NC(CC3CCC3)C(=O)C(N)=O)C2(C)C)C(C)(C)C",1.623,5,4,10]
["S3756","Methyl salicylate","b11","L6200-09","in 10mM DMSO","TRP Channel","Transmembrane Transporters","Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.",152.15,"119-36-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/methyl-salicylate.html","C8H8O3","free base","2-Carbomethoxyphenol, Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil","COC(=O)C1=C(O)C=CC=C1",1.443,2,1,2]
["S3758","Sinomenine hydrochloride","c11","L6200-09","in 10mM DMSO","Autophagy,Immunology & Inflammation related","Immunology & Inflammation","Sinomenine (SN, Cucoline, Kukoline, Sabianine A), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.",365.85,"6080-33-7",{"v":73,"d":"73.00"},199.54,"N/A","N/A","http://selleckchem.com/products/sinomenine-hydrochloride.html","C19H23NO4.HCl","hydrochloride","Cucoline hydrochloride, Kukoline hydrochloride, Sabianine A hydrochloride","Cl.COC1=C(O)C2=C(CC3C4C=C(OC)C(=O)CC24CCN3C)C=C1",2.056,3,1,2]
["S3764","Isoferulic Acid","d11","L6200-09","in 10mM DMSO","Adrenergic Receptor","GPCR & G Protein","Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties.  Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.",194.18,"537-73-5",{"v":38,"d":"38.00"},195.69,"N/A","N/A","http://selleckchem.com/products/isoferulic-acid.html","C10H10O4","free base","Hesperetic acid, Hesperetate, Isoferulate","COC1=C(O)C=C(\\C=C\\C(O)=O)C=C1",1.669,2,1,3]
["S3765","Picroside II","e11","L6200-09","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.",512.46,"39012-20-9",{"v":100,"d":"100.00"},195.14,"N/A","N/A","http://selleckchem.com/products/picroside-ii.html","C23H28O13","free base","6-Vanilloylcatalpol, Vanilloyl catalpol","COC1=CC(=CC=C1O)C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C5(CO)OC25",-1.796,7,6,8]
["S3769","Palmatine","f11","L6200-09","in 10mM DMSO","AChR","Neuronal Signaling","Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.",{"v":352.4,"d":"352.40"},"3486-67-7",{"v":70,"d":"70.00"},198.64,"N/A","N/A","http://selleckchem.com/products/palmatine.html","C21H22NO4","free base","Berbericinine, Burasaine","COC1=CC2=C(C=C1OC)C3=CC4=C(C=[N+]3CC2)C(=C(OC)C=C4)OC",4.161,4,0,4]
["S3771","Stachydrine","g11","L6200-09","in 10mM DMSO","NF-κB","NF-κB","Stachydrine (Proline betaine, L-stachydrine, Methyl hygrate betaine) is a quaternary ammonium derivative of proline that occurs widely in Medicago species. It is an osmoprotective compound found in urine. Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.",143.18,"471-87-4",{"v":28,"d":"28.00"},195.56,"N/A","N/A","http://selleckchem.com/products/stachydrine.html","C7H13NO2","inner salt","Proline betaine, L-stachydrine, Methyl hygrate betaine","C[N+]1(C)CCCC1C([O-])=O",-2.431,0,0,1]
["S3773","Tyrosol","h11","L6200-09","in 10mM DMSO","NF-κB","NF-κB","Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives.  Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.",138.16,"501-94-0",{"v":27,"d":"27.00"},195.43,"N/A","N/A","http://selleckchem.com/products/tyrosol.html","C8H10O2","free base","4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol","OCCC1=CC=C(O)C=C1",1.304,0,2,2]
["S3775","Ligustrazine hydrochloride","a2","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ligustrazine hydrochloride (Tetramethylpyrazine, Tetrapyrazine) is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.",172.66,"76494-51-4",{"v":34,"d":"34.00"},196.92,"N/A","N/A","http://selleckchem.com/products/ligustrazine-hydrochloride.html","C8H12N2.HCl","hydrochloride","Tetramethylpyrazine HCl, Tetrapyrazine HCl","Cl.CC1=NC(=C(C)N=C1C)C",1.041,2,0,0]
["S3777","Gentiopicroside","b2","L6200-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Gentiopicroside (GE, Gentiopicrin), a naturally occurring iridoid glycoside, inhibits CYP2A6 and CYP2E1 with IC50 values of 21.8μg/ml and 594μg/ml, respectively in human liver microsomes, and  dose not inhibit CYP2C9, CYP2D6, CYP1A2 or CYP3A4 activities.",356.32,"20831-76-9",{"v":71,"d":"71.00"},199.26,"N/A","N/A","http://selleckchem.com/products/gentiopicroside.html","C16H20O9","free base","Gentiopicrin","OCC1OC(OC2OC=C3C(=O)OCC=C3C2C=C)C(O)C(O)C1O",-1.523,5,4,4]
["S3780","Secoisolariciresinol diglucoside","c2","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.",{"v":686.7,"d":"686.70"},"148244-82-0",{"v":100,"d":"100.00"},145.62,{"v":100,"d":"100.00"},145.62,"http://selleckchem.com/products/secoisolariciresinol-diglucoside.html","C32H46O16","free base","N/A","COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC",-0.651,6,10,15]
["S3781","Ginkgolide C","d2","L6200-10","in 10mM DMSO","MMP","Proteases","Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.",{"v":440.4,"d":"440.40"},"15291-76-6",{"v":88,"d":"88.00"},199.82,"N/A","N/A","http://selleckchem.com/products/ginkgolide-c.html","C20H24O11","free base","BN-52022","CC1C(=O)OC2C(O)C34C5OC(=O)C3(OC6OC(=O)C(O)C46C(C5O)C(C)(C)C)C12O",-1.753,7,3,1]
["S3783","Echinacoside","e2","L6200-10","in 10mM DMSO","Tyrosinase","Protein Tyrosine Kinase","Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.",786.73,"82854-37-3",{"v":100,"d":"100.00"},127.11,"N/A","N/A","http://selleckchem.com/products/echinacoside.html","C35H46O20","free base","N/A","CC1OC(OC2C(O)C(OCCC3=CC(=C(O)C=C3)O)OC(COC4OC(CO)C(O)C(O)C4O)C2OC(=O)\\C=C\\C5=CC=C(O)C(=C5)O)C(O)C(O)C1O",-1.263,8,12,14]
["S3784","Obacunone (AI3-37934)","f2","L6200-10","in 10mM DMSO","Aromatase,Nrf2","Endocrinology & Hormones","Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.",454.51,"751-03-1",{"v":90,"d":"90.00"},198.02,"N/A","N/A","http://selleckchem.com/products/obacunone.html","C26H30O7","free base","CCRIS 8657","CC1(C)OC(=O)C=CC2(C)C3CCC4(C)C(OC(=O)C5OC45C3(C)C(=O)CC12)C6=COC=C6",2.715,7,0,1]
["S3785","Notoginsenoside R1","g2","L6200-10","in 10mM DMSO","Akt,ERK,PAI-1,PI3K","Metabolism","Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.",933.13,"80418-24-2",{"v":100,"d":"100.00"},107.17,"N/A","N/A","http://selleckchem.com/products/notoginsenoside-r1.html","C47H80O18","free base","Sanchinoside R1, NG-R1, NGR1","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(CO)C(O)C(O)C6OC7OCC(O)C(O)C7O",{"v":-0.11,"d":"-0.110"},6,12,12]
["S3786","Glabridin","h2","L6200-10","in 10mM DMSO","GABA Receptor,PPAR","Metabolism","Glabridin (Q-100692, KB-289522, LS-176045), one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.",324.37,"59870-68-7",{"v":64,"d":"64.00"},197.31,"N/A","N/A","http://selleckchem.com/products/glabridin.html","C20H20O4","free base","Q-100692, KB-289522, LS-176045","CC1(C)OC2=C(C=C1)C3=C(CC(CO3)C4=CC=C(O)C=C4O)C=C2",3.999,2,2,1]
["S3787","Picroside I","a3","L6200-10","in 10mM DMSO","Anti-infection","Microbiology","Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.",492.47,"27409-30-9",{"v":98,"d":"98.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/picroside-i.html","C24H28O11","free base","6'-Cinnamoylcatalpol","OCC12OC1C(O)C3C=COC(OC4OC(COC(=O)\\C=C\\C5=CC=CC=C5)C(O)C(O)C4O)C23",{"v":-1.07,"d":"-1.070"},6,5,8]
["S3788","Carvacrol","b3","L6200-10","in 10mM DMSO","AChR","Neuronal Signaling","Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.",150.22,"499-75-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/carvacrol.html","C10H14O","free base","cymophenol","CC(C)C1=CC=C(C)C(=C1)O",3.268,0,1,1]
["S3790","Methyl gallate","c3","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.",184.15,"99-24-1",{"v":36,"d":"36.00"},359.57,"N/A","N/A","http://selleckchem.com/products/methyl-gallate.html","C8H8O5","free base","Methylgallate, Gallic acid methyl ester, Gallicin","COC(=O)C1=CC(=C(O)C(=C1)O)O",0.959,2,3,2]
["S3792","Guggulsterone E&Z","d3","L6200-10","in 10mM DMSO","FXR","Metabolism","Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.",312.45,"95975-55-6",{"v":62,"d":"62.00"},198.43,"N/A","N/A","http://selleckchem.com/products/guggulsterone.html","C21H28O2","free base","N/A","CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C",4.031,2,0,0]
["S3794","Palmitic acid","e3","L6200-10","in 10mM DMSO","Others","Others","Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.",256.42,"57-10-3",{"v":51,"d":"51.00"},198.89,"N/A","N/A","http://selleckchem.com/products/palmitic-acid.html","C16H32O2","free base","hexadecanoic acid, Cetylic acid","CCCCCCCCCCCCCCCC(O)=O",6.393,1,0,14]
["S3799","Gentisic acid","f3","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Gentisic acid (2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Hydroquinonecarboxylic acid, DHB), an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.",154.12,"490-79-9",{"v":30,"d":"30.00"},194.65,"N/A","N/A","http://selleckchem.com/products/gentisic-acid.html","C7H6O4","free base","DHB, 2,5-dihydroxybenzoic acid, 5-Hydroxysalicylic acid, Gentianic acid, Carboxyhydroquinone, Hydroquinonecarboxylic acid","OC(=O)C1=C(O)C=CC(=C1)O",0.975,1,2,1]
["S3800","Lycorine hydrochloride","g3","L6200-10","in 10mM DMSO","ADC Cytotoxin,HCV Protease","Proteases","Lycorine (Galanthidine, Amarylline, Narcissine, Licorine), a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. It is an HCV inhibitor with strong activity.",323.77,"2188-68-3",{"v":64,"d":"64.00"},197.67,"N/A","N/A","http://selleckchem.com/products/lycorine-hydrochloride.html","C16H17NO4.HCl","hydrochloride","Galanthidine hydrochloride, Amarylline hydrochloride, Narcissine hydrochloride, Licorine hydrochloride","Cl.OC1C=C2CCN3CC4=C(C=C5OCOC5=C4)C(C1O)C23",1.095,2,2,0]
["S3802","Trigonelline Hydrochloride","h3","L6200-10","in 10mM DMSO","Bacterial","Microbiology","Trigonelline (Nicotinic acid N-methylbetaine, Coffearine, Gynesine), a major alkaloid component of fenugreek, has hypoglycemic, hypolipidemic, neuroprotective, antimigraine, sedative, memory-improving, antibacterial, antiviral, and anti-tumor activities, and also has been shown to reduce diabetic auditory neuropathy and platelet aggregation.",{"v":173.6,"d":"173.60"},"6138-41-6",{"v":18,"d":"18.00"},103.69,"N/A","N/A","http://selleckchem.com/products/trigonelline-hydrochloride.html","C7H8NO2.Cl","chloride","Nicotinic acid N-methylbetaine Hydrochloride, Coffearine Hydrochloride, Gynesine Hydrochloride","[Cl-].C[N+]1=CC(=CC=C1)C(O)=O",{"v":-1.61,"d":"-1.610"},1,0,1]
["S3804","Alpha-Mangostin","a4","L6200-10","in 10mM DMSO","Dehydrogenase,STING","Metabolism","Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities.    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.",410.46,"6147-11-1",{"v":82,"d":"82.00"},199.78,"N/A","N/A","http://selleckchem.com/products/alpha-mangostin.html","C24H26O6","free base","N/A","COC1=C(O)C=C2OC3=C(C(=C(CC=C(C)C)C(=C3)O)O)C(=O)C2=C1CC=C(C)C",5.935,3,3,5]
["S3807","Dehydroandrographolide","b4","L6200-10","in 10mM DMSO","Chloride Channel","Transmembrane Transporters","Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.",332.43,"134418-28-3",{"v":66,"d":"66.00"},198.54,"N/A","N/A","http://selleckchem.com/products/dehydroandrographolide.html","C20H28O4","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C3/C=COC3=O)C(=C)CCC12",2.502,2,2,3]
["S3808","Mangiferin","c4","L6200-10","in 10mM DMSO","NF-κB,Nrf2","Immunology & Inflammation","Mangiferin (Alpizarin, Chinomin, Hedysarid) is a bioactive compound that demonstrates many health perspectives and has been used to prepare medicinal and food supplements. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.",422.34,"4773-96-0",{"v":84,"d":"84.00"},198.89,"N/A","N/A","http://selleckchem.com/products/mangiferin.html","C19H18O11","free base","Alpizarin, Chinomin, Hedysarid","OCC1OC(C(O)C(O)C1O)C2=C(O)C=C3OC4=C(C=C(O)C(=C4)O)C(=O)C3=C2O",-0.396,3,8,2]
["S3810","Scutellarin","d4","L6200-10","in 10mM DMSO","Akt,NF-κB,STAT","JAK/STAT","Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.",462.36,"27740-01-8",{"v":50,"d":"50.00"},108.14,"N/A","N/A","http://selleckchem.com/products/scutellarin.html","C21H18O12","free base","Breviscapine, Breviscapin, Scutellarein-7-glucuronide","OC1C(O)C(OC(C1O)C(O)=O)OC2=CC3=C(C(=O)C=C(O3)C4=CC=C(O)C=C4)C(=C2O)O",0.366,5,6,4]
["S3811","Ginsenoside Re","e4","L6200-10","in 10mM DMSO","Beta Amyloid,JNK,NF-κB","Neuronal Signaling","Ginsenoside Re (Ginsenoside B2, Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc), an extract from Panax notoginseng, is a major ginsenoside in ginseng and belongs to 20(S)-protopanaxatriol group. It has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.",947.15,"52286-59-6",{"v":100,"d":"100.00"},105.58,"N/A","N/A","http://selleckchem.com/products/ginsenoside-re.html","C48H82O18","free base","Panaxoside Re, Sanchinoside Re, Chikusetsusaponin Ivc","CC1OC(OC2C(O)C(O)C(CO)OC2OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C1O",0.267,6,12,12]
["S3813","Bakuchiol","f4","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.",256.38,"10309-37-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/bakuchiol.html","C18H24O","free base","(S)-(+)-Bakuchiol","CC(C)=CCCC(C)(C=C)\\C=C\\C1=CC=C(O)C=C1",5.348,0,1,6]
["S3815","Mogroside V","g4","L6200-10","in 10mM DMSO","Others","Others","Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).",1287.43,"88901-36-4",{"v":100,"d":"100.00"},77.67,"N/A","N/A","http://selleckchem.com/products/mogroside-v.html","C60H102O29","free base","N/A","CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1OC3OC(CO)C(O)C(O)C3O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C",{"v":-3.98,"d":"-3.980"},10,18,20]
["S3816","Dehydroevodiamine","h4","L6200-10","in 10mM DMSO","COX,NF-κB,PGES,ROS","Immunology & Inflammation","Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.",301.34,"67909-49-3",{"v":19,"d":"19.00"},63.05,"N/A","N/A","http://selleckchem.com/products/dehydroevodiamine.html","C19H15N3O","inner salt","DHED","C[N+]1=C2N(CCC3=C2[N-]C4=C3C=CC=C4)C(=O)C5=C1C=CC=C5",3.186,1,0,0]
["S3817","Harmine hydrochloride","a5","L6200-10","in 10mM DMSO","5-HT Receptor,ADC Cytotoxin,DYRK,MAO","Cell Cycle","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",248.71,"343-27-1",{"v":21,"d":"21.00"},84.44,"N/A","N/A","http://selleckchem.com/products/harmine-hydrochloride.html","C13H12N2O.HCl","hydrochloride","Telepathine hydrochloride","Cl.COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",{"v":2.82,"d":"2.820"},2,1,1]
["S3818","Tectoridin","b5","L6200-10","in 10mM DMSO","Others","Others","Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.",{"v":462.4,"d":"462.40"},"611-40-5",{"v":92,"d":"92.00"},198.96,"N/A","N/A","http://selleckchem.com/products/tectoridin.html","C22H22O11","free base","Shekanin","COC1=C(O)C2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1OC4OC(CO)C(O)C(O)C4O",0.194,5,6,5]
["S3819","Decursinol angelate","c5","L6200-10","in 10mM DMSO","PKC","Cytoskeletal Signaling","Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.",328.36,"130848-06-5",{"v":65,"d":"65.00"},197.95,"N/A","N/A","http://selleckchem.com/products/decursinol-angelate.html","C19H20O5","free base","N/A","C\\C=C(C)/C(=O)OC1CC2=CC3=C(OC(=O)C=C3)C=C2OC1(C)C",3.955,5,0,3]
["S3822","Schisandrin A","d5","L6200-10","in 10mM DMSO","AdipoR","Metabolism","Schisandrin A (Sch A, Deoxyschizandrin, Wuweizisu A) is an active component of Schisandrae Fructus with liver-protective, antitumor, and antioxidant activities. It is an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM.",416.51,"61281-38-7",{"v":83,"d":"83.00"},199.27,"N/A","N/A","http://selleckchem.com/products/schisandrin-a.html","C24H32O6","free base","Deoxyschizandrin, Wuweizisu A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)C2)C=C(OC)C(=C3OC)OC",5.266,6,0,6]
["S3823","Schizandrol A","e5","L6200-10","in 10mM DMSO","Others","Neuronal Signaling","Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.",432.51,"7432-28-2",{"v":86,"d":"86.00"},198.84,"N/A","N/A","http://selleckchem.com/products/schizandrol-a.html","C24H32O7","free base","N/A","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)(O)C(C)C2)C=C(OC)C(=C3OC)OC",{"v":4.05,"d":"4.050"},6,0,6]
["S3824","Quercitrin","f5","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.",448.38,"522-12-3",{"v":89,"d":"89.00"},198.49,"N/A","N/A","http://selleckchem.com/products/quercitrin.html","C21H20O11","free base","3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine","CC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.589,4,7,3]
["S3826","Hydroxytyrosol","g5","L6200-10","in 10mM DMSO","Others","Others","Hydroxytyrosol (3,4-dihydroxyphenylethanol) is one of the main phenolic components of olive oil with excellent antioxidant, antimicrobial and anticarcinogenic activities.",154.16,"10597-60-1",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol.html","C8H10O3","free base","3-Hydroxytyrosol; 3,4-dihydroxyphenylethanol; Dihydroxyphenylethanol; 2-(3,4-Di-hydroxyphenyl)-ethanol","OCCC1=CC=C(O)C(=C1)O",1.062,0,3,2]
["S3828","Orcinol glucoside","h5","L6200-10","in 10mM DMSO","Others","Others","Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects.",286.28,"21082-33-7",{"v":58,"d":"58.00"},{"v":202.6,"d":"202.60"},"N/A","N/A","http://selleckchem.com/products/orcinol-glucoside.html","C13H18O7","free base","Sakakin","CC1=CC(=CC(=C1)OC2OC(CO)C(O)C(O)C2O)O",-0.098,2,5,3]
["S3829","Isoalantolactone","a6","L6200-10","in 10mM DMSO","Apoptosis related,Fungal","Apoptosis","Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia.  Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.",232.32,"470-17-7",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"N/A","N/A","http://selleckchem.com/products/isoalantolactone.html","C15H20O2","Sesquiterpene lactone","N/A","CC12CCCC(=C)C1CC3C(C2)OC(=O)C3=C",3.365,2,0,0]
["S3832","Euphorbiasteroid","b6","L6200-10","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Euphorbiasteroid (Euphorbia factor L1), a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway and induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a dose-dependent manner. Euphorbiasteroid is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect.",552.66,"28649-59-4",{"v":21,"d":"21.00"},{"v":38,"d":"38.00"},"N/A","N/A","http://selleckchem.com/products/euphorbiasteroid.html","C32H40O8","free base","Euphorbia factor L1","CC1CC2(OC(C)=O)C(C1OC(=O)CC3=CC=CC=C3)C(OC(C)=O)C4(CCC5C(\\C=C(C)\\C2=O)C5(C)C)CO4",4.183,8,0,8]
["S3833","Amentoflavone","c6","L6200-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.",538.46,"1617-53-4",{"v":100,"d":"100.00"},185.71,"N/A","N/A","http://selleckchem.com/products/amentoflavone.html","C30H18O10","free base","Didemethyl Ginkgetin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(O)C=C3O)C4=CC(=CC=C4O)C5=CC(=O)C6=C(O5)C=C(O)C=C6O",4.509,4,6,3]
["S3834","Astaxanthin","d6","L6200-10","in 10mM DMSO","PPAR","Metabolism","Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.",596.84,"472-61-7",{"v":100,"d":"100.00"},167.55,"N/A","N/A","http://selleckchem.com/products/astaxanthin.html","C40H52O4","free base","β-Carotene-4,4'-dione, Trans-Astaxanthin","CC(=C\\C=C\\C=C(C)\\C=C\\C=C(C)\\C=C\\C1=C(C)C(=O)C(O)CC1(C)C)/C=C/C=C(C)/C=C/C2=C(C)C(=O)C(O)CC2(C)C",8.421,2,2,10]
["S3835","Loganin","e6","L6200-10","in 10mM DMSO","AChR,BACE,BChE","Neuronal Signaling","Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.",390.38,"18524-94-2",{"v":78,"d":"78.00"},199.81,"N/A","N/A","http://selleckchem.com/products/loganin.html","C17H26O10","free base","Loganoside","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)C(O)CC13",-1.895,5,5,5]
["S3836","6-Gingerol","f6","L6200-10","in 10mM DMSO","Apoptosis related","Apoptosis","6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.",294.39,"23513-14-6",{"v":58,"d":"58.00"},197.02,"N/A","N/A","http://selleckchem.com/products/6-gingerol.html","C17H26O4","free base","N/A","CCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",3.638,2,2,10]
["S3837","Echinocystic acid","g6","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.",{"v":472.7,"d":"472.70"},"510-30-5",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/echinocystic-acid.html","C30H48O4","free base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",5.345,1,2,1]
["S3838","Carnosic acid","h6","L6200-10","in 10mM DMSO","ROS","Immunology & Inflammation","Carnosic acid (Salvin) is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.",332.43,"3650-09-7",{"v":66,"d":"66.00"},198.54,"N/A","N/A","http://selleckchem.com/products/carnosic-acid.html","C20H28O4","free base","Salvin","CC(C)C1=CC2=C(C(=C1O)O)C3(CCCC(C)(C)C3CC2)C(O)=O",4.905,1,2,2]
["S3839","1-Deoxynojirimycin","a7","L6200-10","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.",163.17,"19130-96-2",{"v":16,"d":"16.00"},98.06,"N/A","N/A","http://selleckchem.com/products/1-deoxynojirimycin.html","C6H13NO4","free base","duvoglustat, moranolin","OCC1NCC(O)C(O)C1O",{"v":-2.44,"d":"-2.440"},0,5,1]
["S3840","Baohuoside I","b7","L6200-10","in 10mM DMSO","ROS","Immunology & Inflammation","Baohuoside I (Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai with anti-inflammatory and anti-cancer activities. It may exert cytotoxic effect via the ROS/MAPK pathway.",514.52,"113558-15-9",{"v":100,"d":"100.00"},194.36,"N/A","N/A","http://selleckchem.com/products/baohuoside-i.html","C27H30O10","Flavonoid glycoside","Icariside II","COC1=CC=C(C=C1)C2=C(OC3OC(C)C(O)C(O)C3O)C(=O)C4=C(O)C=C(O)C(=C4O2)CC=C(C)C",2.913,5,5,6]
["S3842","Isoquercitrin","c7","L6200-10","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.",464.38,"482-35-9",{"v":92,"d":"92.00"},198.11,"N/A","N/A","http://selleckchem.com/products/isoquercitrin.html","C21H20O12","free base","Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside","OCC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S3843","Madecassoside","d7","L6200-10","in 10mM DMSO","Others","Others","Madecassoside (Asiaticoside A) is the main active triterpene constituent of Centella asiatica herbs, a traditional Chinese medicine for wound healing and scar management.",975.12,"34540-22-2",{"v":100,"d":"100.00"},102.55,{"v":100,"d":"100.00"},102.55,"http://selleckchem.com/products/madecassoside.html","C48H78O20","free base","Asiaticoside A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O",{"v":-1.27,"d":"-1.270"},7,13,10]
["S3846","Eupatilin","e7","L6200-10","in 10mM DMSO","PPAR","Metabolism","Eupatilin (NSC 122413), a major flavonoid from Artemisia plants, possesses various beneficial biological effects including anti-inflammation, anti-tumor, anti-cancer, anti-allergy, and anti-oxidation activity. Eupatilin, a lipophilic flavonoid isolated from Artemisia species, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.",344.32,"22368-21-4",{"v":68,"d":"68.00"},197.49,"N/A","N/A","http://selleckchem.com/products/eupatilin.html","C18H16O7","free base","NSC 122413","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)OC",2.603,5,2,4]
["S3848","Hydroxytyrosol Acetate","f7","L6200-10","in 10mM DMSO","Others","Others","Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.",{"v":196.2,"d":"196.20"},"69039-02-7",{"v":39,"d":"39.00"},198.78,"N/A","N/A","http://selleckchem.com/products/hydroxytyrosol-acetate.html","C10H12O4","free base","HTy-Ac","CC(=O)OCCC1=CC(=C(O)C=C1)O",1.441,2,2,4]
["S3849","D-Galactose","g7","L6200-10","in 10mM DMSO","Others","Others","D-Galactose (D-Galactopyranose, D-(+)-Galactose) is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.",180.16,"59-23-4",{"v":36,"d":"36.00"},199.82,"N/A","N/A","http://selleckchem.com/products/d-galactose.html","C6H12O6","free base","D-Galactopyranose, D-(+)-Galactose","OCC1OC(O)C(O)C(O)C1O",-2.514,1,4,1]
["S3855","Ethyl ferulate","h7","L6200-10","in 10mM DMSO","Others","Others","Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.",222.24,"4046-02-0",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/ethyl-ferulate.html","C12H14O4","free base","Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate","CCOC(=O)/C=C/C1=CC(=C(O)C=C1)OC",2.243,3,1,5]
["S3857","4-Hydroxybenzyl alcohol","a8","L6200-10","in 10mM DMSO","Apoptosis related","Apoptosis","4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.",124.14,"623-05-2",{"v":24,"d":"24.00"},193.33,"N/A","N/A","http://selleckchem.com/products/4-hydroxybenzyl-alcohol.html","C7H8O2","free base","P-Methylolphenol, 4-Methylolphenol","OCC1=CC=C(O)C=C1",0.983,0,2,1]
["S3859","Vanillyl Alcohol","b8","L6200-10","in 10mM DMSO","Others","Others","Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol), derived from vanillin, is used to flavor food.",154.16,"498-00-0",{"v":30,"d":"30.00"},{"v":194.6,"d":"194.60"},"N/A","N/A","http://selleckchem.com/products/vanillyl-alcohol.html","C8H10O3","free base","4-Hydroxy-3-methoxybenzyl alcohol, Vanillin alcohol, Vanillic alcohol, 3-Methoxy-4-hydroxybenzyl alcohol, 4-Hydroxy-3-methoxybenzenemethanol","COC1=CC(=CC=C1O)CO",0.967,1,2,2]
["S3860","Allicin","c8","L6200-10","in 10mM DMSO","Fungal","Metabolism","Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects., Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.",162.27,"539-86-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/allicin.html","C6H10OS2","free base","diallyl thiosulfinate","C=CCS[S](=O)CC=C",2.005,1,0,5]
["S3862","Gallic acid trimethyl ether","d8","L6200-10","in 10mM DMSO","Others","Others","Gallic acid trimethyl ether (Eudesmic acid, Tri-O-methylgallic acid, Benzoic acid, 3,4,5-Trimethoxybenzoic acid) is an O-methylated trihydroxybenzoic acid that is found in olive.",{"v":212.2,"d":"212.20"},"118-41-2",{"v":42,"d":"42.00"},197.93,"N/A","N/A","http://selleckchem.com/products/gallic-acid-trimethyl-ether.html","C10H12O5","free base","Eudesmic acid, Tri-O-methylgallic acid, Benzoic acid, 3,4,5-Trimethoxybenzoic acid","COC1=CC(=CC(=C1OC)OC)C(O)=O",{"v":1.41,"d":"1.410"},4,0,4]
["S3867","(E)-Cardamonin","e8","L6200-10","in 10mM DMSO","NF-κB,TRP Channel","NF-κB","(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.",270.28,"19309-14-9",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/e-cardamoni.html","C16H14O4","free base","Alpinetin chalcone, cardamomin","COC1=CC(=CC(=C1C(=O)\\C=C\\C2=CC=CC=C2)O)O",3.201,2,2,4]
["S3868","Harmine","f8","L6200-10","in 10mM DMSO","MAO,PPAR","Metabolism","Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.",212.25,"442-51-3",{"v":42,"d":"42.00"},197.88,"N/A","N/A","http://selleckchem.com/products/harmine.html","C13H12N2O","free base","Telepathine","COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C",2.438,2,1,1]
["S3869","Methyl protocatechuate","g8","L6200-10","in 10mM DMSO","Others","Others","Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.",168.15,"2150-43-8",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/methyl-protocatechuate.html","C8H8O4","free base","Methyl 3,4-dihydroxybenzoate; 3,4-Dihydroxybenzoic acid methyl ester; Protocatechuic Acid Methyl Ester","COC(=O)C1=CC(=C(O)C=C1)O",1.201,2,2,2]
["S3870","D-Pinitol","h8","L6200-10","in 10mM DMSO","Influenza Virus","Microbiology","D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.",194.18,"10284-63-6",{"v":38,"d":"38.00"},195.69,"N/A","N/A","http://selleckchem.com/products/d-pinitol.html","C7H14O6","free base","Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol","COC1C(O)C(O)C(O)C(O)C1O",-2.656,1,5,1]
["S3871","Muscone","a9","L6200-10","in 10mM DMSO","Immunology & Inflammation related,Interleukins,NF-κB,NLRP3,TNF-alpha","NF-κB","Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent. Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).",238.41,"541-91-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/muscone.html","C16H30O","free base","3-Methylcyclopentadecanone, Methylexaltone","CC1CCCCCCCCCCCCC(=O)C1",5.672,1,0,0]
["S3872","Guaiacol","b9","L6200-10","in 10mM DMSO","COX,NF-κB","NF-κB","Guaiacol (O-methoxyphenol, 2-hydroxyanisole, O-methylcatechol) is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. It is a precursor to various flavorants, such as eugenoland vanillin. Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity.",124.14,"90-05-1",{"v":24,"d":"24.00"},193.33,"N/A","N/A","http://selleckchem.com/products/guaiacol.html","C7H8O2","free base","o-methoxyphenol, 2-hydroxyanisole, O-methylcatechol","COC1=C(O)C=CC=C1",1.571,1,1,1]
["S3874","Curcumenol","c9","L6200-10","in 10mM DMSO","NF-κB,P450 (e.g. CYP17)","NF-κB","Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.",234.33,"19431-84-6",{"v":46,"d":"46.00"},{"v":196.3,"d":"196.30"},"N/A","N/A","http://selleckchem.com/products/curcumenol.html","C15H22O2","free base","N/A","CC1CCC2C(=CC3(O)OC12CC3=C(C)C)C",3.268,1,0,0]
["S3875","Alpinetin","d9","L6200-10","in 10mM DMSO","PPAR","Metabolism","Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities.  Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.",270.28,"36052-37-6",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/alpinetin.html","C16H14O4","free base","N/A","COC1=CC(=CC2=C1C(=O)CC(O2)C3=CC=CC=C3)O",2.841,3,1,2]
["S3879","Kaempferide","e9","L6200-10","in 10mM DMSO","EGFR","Apoptosis","Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether), a natural compound derived from the roots of kaempferia galanga, has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.",300.26,"491-54-3",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://selleckchem.com/products/kaempferide.html","C16H12O6","free base","4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",2.098,3,3,2]
["S3880","Schisantherin A","f9","L6200-10","in 10mM DMSO","NF-κB","NF-κB","Schisantherin A (Gomisin C, Schisanwilsonin H, Arisanschinin K) is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.",536.57,"58546-56-8",{"v":100,"d":"100.00"},186.37,"N/A","N/A","http://selleckchem.com/products/schisantherin-a.html","C30H32O9","free base","Gomisin C, Schisanwilsonin H, Arisanschinin K","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)(O)C2OC(=O)C4=CC=CC=C4)C=C5OCOC5=C3OC",5.063,8,0,7]
["S3881","Scopoletin","g9","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.",192.17,"92-61-5",{"v":38,"d":"38.00"},197.74,"N/A","N/A","http://selleckchem.com/products/scopoletin.html","C10H8O4","free base","Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid","COC1=CC2=C(OC(=O)C=C2)C=C1O",1.641,3,1,1]
["S3883","Protopine","h9","L6200-10","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.",353.37,"130-86-9",{"v":30,"d":"30.00"},{"v":84.9,"d":"84.90"},"N/A","N/A","http://selleckchem.com/products/protopine.html","C20H19NO5","free base","Corydinine, Fumarine, Biflorine, Macleyine","CN1CCC2=C(C=C3OCOC3=C2)C(=O)CC4=C(C1)C5=C(OCO5)C=C4",2.953,5,0,0]
["S3884","Jatrorrhizine","a10","L6200-10","in 10mM DMSO","AChR","Neuronal Signaling","Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.",338.38,"3621-38-3",{"v":67,"d":"67.00"},{"v":198,"d":"198.00"},"N/A","N/A","http://selleckchem.com/products/jatrorrhizine.html","C20H20NO4","free base","Neprotin, Yatrorizine","COC1=CC2=C(CC[N+]3=CC4=C(C=CC(=C4OC)OC)C=C23)C=C1O",3.936,3,1,3]
["S3885","Pyrogallol","b10","L6200-10","in 10mM DMSO","ROS","Immunology & Inflammation","Pyrogallol (1,2,3-trihydroxybenzene), an organic compound belonging to the phenol family, used as a photographic film developer and in the preparation of other chemicals. It is known to be a superoxide anion generator and ROS inducer.",126.11,"87-66-1",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/pyrogallol.html","C6H6O3","free base","1,2,3-trihydroxybenzene","OC1=C(O)C(=CC=C1)O",1.103,0,3,0]
["S3888","3,4',5-Trimethoxy-trans-stilbene","c10","L6200-10","in 10mM DMSO","p38 MAPK","Apoptosis","3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.",270.32,"22255-22-7",{"v":54,"d":"54.00"},199.76,"N/A","N/A","http://selleckchem.com/products/3-4-5-trimethoxy-trans-stilbene.html","C17H18O3","free base","MR-3","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC",3.766,3,0,5]
["S3894","Cycloastragenol","d10","L6200-10","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.",490.72,"84605-18-5",{"v":98,"d":"98.00"},199.71,"N/A","N/A","http://selleckchem.com/products/cycloastragenol.html","C30H50O5","free base","CAG, TA-65, Cyclogalegigenin, Astramembrangenin","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(O)CCC56CC46CCC23C",2.635,1,3,2]
["S3897","(-)-Arctigenin","e10","L6200-10","in 10mM DMSO","Influenza Virus","Microbiology","(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.",372.41,"7770-78-7",{"v":74,"d":"74.00"},198.71,"N/A","N/A","http://selleckchem.com/products/neg-rotation-arctigenin.html","C21H24O6","free base","N/A","COC1=C(O)C=CC(=C1)CC2C(COC2=O)CC3=CC=C(OC)C(=C3)OC",3.743,5,1,7]
["S3898","Hydroxy Camptothecine","f10","L6200-10","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.",364.35,"64439-81-2",{"v":29,"d":"29.00"},79.59,"N/A","N/A","http://selleckchem.com/products/hydroxy-camptothecine.html","C20H16N2O5","free base","10-Hydroxycamptothecin, Hydroxycamptothecine","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=CC5=C(C=CC(=C5)O)N=C34)C2=O",1.504,4,1,1]
["S3899","Hederagenin","g10","L6200-10","in 10mM DMSO","COX,NF-κB,NOS","Immunology & Inflammation","Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB.",{"v":472.7,"d":"472.70"},"465-99-6",{"v":94,"d":"94.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hederagenin.html","C30H48O4","free base","Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1)C(O)=O",5.356,1,2,2]
["S3901","Astragaloside IV","h10","L6200-10","in 10mM DMSO","Akt,ERK,JNK,mTOR,NF-κB","MAPK","Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-Akt, p-mTOR, p-NF-κB and p-Erk1/2.",784.97,"84687-43-4",{"v":100,"d":"100.00"},127.39,"N/A","N/A","http://selleckchem.com/products/sastragaloside-iv.html","C41H68O14","free base","AST-IV, AS-IV","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O",-0.348,5,8,7]
["S3903","Lycorine","a11","L6200-10","in 10mM DMSO","AChR","Neuronal Signaling","Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.",287.31,"476-28-8",{"v":57,"d":"57.00"},198.39,"N/A","N/A","http://selleckchem.com/products/lycorine.html","C16H17NO4","free base","Galanthidine, Amarylline, Narcissine, Licorine, Belamarine","OC1C=C2CCN3CC4=CC5=C(OCO5)C=C4C(C1O)C23",0.713,2,2,0]
["S3905","Iso-Steviol","b11","L6200-10","in 10mM DMSO","Others","Others","Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects.",318.45,"27975-19-5",{"v":63,"d":"63.00"},197.83,"N/A","N/A","http://selleckchem.com/products/iso-steviol.html","C20H30O3","free base","N/A","CC12CCC3C4(C)CCCC(C)(C4CCC3(CC1=O)C2)C(O)=O",3.924,2,0,1]
["S3906","Astragalus polyphenols","c11","L6200-10","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.",406.38,"82373-94-2",{"v":81,"d":"81.00"},199.32,"N/A","N/A","http://selleckchem.com/products/astragalus-polyphenols.html","C20H22O9","free base","N/A","OCC1OC(OC2=C(\\C=C\\C3=CC=C(O)C=C3)C=C(O)C=C2O)C(O)C(O)C1O",0.918,2,7,5]
["S3909","Catalpol","d11","L6200-10","in 10mM DMSO","Others","Others","Catalpol (Catalpinoside, Digitalis purpurea L), an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models.",362.33,"2415-24-9",{"v":72,"d":"72.00"},198.71,"N/A","N/A","http://selleckchem.com/products/catalpol.html","C15H22O10","free base","Catalpinoside, Digitalis purpurea L","OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O",-3.581,4,6,4]
["S3915","Gracillin","e11","L6200-10","in 10mM DMSO","Others","Others","Gracillin, a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica, has been reported to exert antitumor activity.",885.04,"19083-00-2",{"v":100,"d":"100.00"},112.99,"N/A","N/A","http://selleckchem.com/products/gracillin.html","C45H72O17","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C7OC9OC(C)C(O)C(O)C9O",0.281,8,9,8]
["S3917","Tetrahydrocurcumin","f11","L6200-10","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Tetrahydrocurcumin (Tetrahydrodiferuloylmethane, Tetrahydro Curcumin), a major metabolite of curcumin, possesses strong antioxidant and cardioprotective properties.  Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.",372.41,"36062-04-1",{"v":74,"d":"74.00"},{"v":198.7,"d":"198.70"},"<1","N/A","https://www.selleckchem.com/products/tetrahydrocurcumin.html","C21H24O6","free base","Tetrahydrodiferuloylmethane, Tetrahydro Curcumin","COC1=C(O)C=CC(=C1)CCC(=O)CC(=O)CCC2=CC=C(O)C(=C2)OC",-0.415,9,13,12]
["S3922","(-)-epigallocatechin","g11","L6200-10","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","(-)-Epigallocatechin, widespread in plants, has been shown to exhibit anti-tumor, anti-cancer and anti-inflammatory functions.",306.27,"970-74-1",{"v":61,"d":"61.00"},199.17,"N/A","N/A","http://selleckchem.com/products/neg-rotation-epigallocatechin.html","C15H14O7","free base","N/A","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S3923","Ginsenoside Rg1","h11","L6200-10","in 10mM DMSO","Beta Amyloid,NF-κB","Neuronal Signaling","Ginsenoside Rg1 (Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1), one of the major active components of ginseng, is identified as a protopanaxatriol-type and has pharmacological actions such as neuroprotective and anti-tumor effects on various cancer types. Ginsenoside Rg1 reduces cerebral Aβ levels and NF-κB nuclear translocation.",801.01,"22427-39-0",{"v":100,"d":"100.00"},124.84,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rg1.html","C42H72O14","free base","Ginsenoside A2, Panaxoside A, Panaxoside Rg1, Sanchinoside C1, Sanchinoside Rg1","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(CO)C(O)C(O)C6O",1.126,4,10,10]
["S3924","Ginsenoside Rb1","a2","L6200-11","in 10mM DMSO","ATPase,IFN,IRAK,NF-κB,NOS,TLR,TNF-alpha","Transmembrane Transporters","Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.",1109.29,"41753-43-9",{"v":100,"d":"100.00"},90.15,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rb1.html","C54H92O23","free base","Gypenoside Ⅲ","CC(C)=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C",-1.198,8,15,16]
["S3925","(-)-Epicatechin gallate","b2","L6200-11","in 10mM DMSO","COX","Immunology & Inflammation","(-)-Epicatechin gallate (ECG) is an inhibitor of cyclooxygenase-1 (COX-1) with IC50 of 7.5 μM.",442.37,"1257-08-5",{"v":88,"d":"88.00"},198.93,"N/A","N/A","http://selleckchem.com/products/epicatechin-gallate.html","C22H18O10","free base","(−)-ECG, (−)-Epicatechin 3-gallate, (−)-Epicatechin-3-O-gallate","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC=C(O)C(=C4)O)C(=C1)O",3.339,3,7,4]
["S3926","Forsythin","c2","L6200-11","in 10mM DMSO","PDE","GPCR & G Protein","Forsythin (FOR, Phillyrin) is an active ingredient extracted from the fruit of the medicinal plant Forsythia suspensa (Thunb.) Vahl and has been shown to have antioxidant, antibacterial and antiinflammatory properties.",534.55,"487-41-2",{"v":100,"d":"100.00"},187.07,"N/A","N/A","http://selleckchem.com/products/forsythin.html","C27H34O11","free base","Phillyrin","COC1=CC=C(C=C1OC)C2OCC3C2COC3C4=CC(=C(OC5OC(CO)C(O)C(O)C5O)C=C4)OC",0.479,7,4,8]
["S3930","Liquiritin","d2","L6200-11","in 10mM DMSO","AKR1C","Immunology & Inflammation","Liquiritin (LIQ, Liquiritoside, Liquiritigenin-4'-O-glucoside) is a main component among the licorice flavonoids, and possesses anti-inflammatory and anti-cancer abilities.",418.39,"551-15-5",{"v":100,"d":"100.00"},239.01,"N/A","N/A","http://selleckchem.com/products/liquiritin.html","C21H22O9","free base","Liquiritoside, Liquiritigenin-4'-O-glucoside","OCC1OC(OC2=CC=C(C=C2)C3CC(=O)C4=C(O3)C=C(O)C=C4)C(O)C(O)C1O",0.686,4,5,4]
["S3931","Ginsenoside Rd","e2","L6200-11","in 10mM DMSO","Calcium Channel,COX,NF-κB,NOS,P450 (e.g. CYP17)","Immunology & Inflammation","Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.",947.15,"52705-93-8",{"v":90,"d":"90.00"},95.02,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rd.html","C48H82O18","free base","Panaxoside Rd, Sanchinoside Rd","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C(C)(C)C5CCC34C",0.548,6,12,13]
["S3932","Astilbin","f2","L6200-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.",450.39,"29838-67-3",{"v":100,"d":"100.00"},222.03,"N/A","N/A","http://selleckchem.com/products/astilbin.html","C21H22O11","free base","Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside","CC1OC(OC2C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",0.621,4,7,3]
["S3933","10-deacetyl-paclitaxel","g2","L6200-11","in 10mM DMSO","Others","Others","10-deacetyl-paclitaxel (10-DAT, Deacetyl Paclitaxel) is a semi-synthetic precursor of Paclitaxel.",811.87,"78432-77-6",{"v":27,"d":"27.00"},33.26,"N/A","N/A","http://selleckchem.com/products/10-deacetyl-paclitaxel.html","C45H49NO13","free base","10-DAT, Deacetyl Paclitaxel","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C(C(O)C3=O)C5(C)C)C",2.676,9,4,12]
["S3934","Acetyl Resveratrol","h2","L6200-11","in 10mM DMSO","Others","Others","Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.",354.35,"42206-94-0",{"v":70,"d":"70.00"},197.54,"<1","N/A","https://www.selleckchem.com/products/acetyl-resveratrol.html","C20H18O6","free base","N/A","CC(=O)OC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)OC(C)=O)OC(C)=O",3.119,6,0,8]
["S3937","Pterostilbene","a3","L6200-11","in 10mM DMSO","Others","Others","Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.",{"v":256.3,"d":"256.30"},"537-42-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","https://www.selleckchem.com/products/pterostilbene.html","C16H16O3","free base","N/A","COC1=CC(=CC(=C1)\\C=C\\C2=CC=C(O)C=C2)OC",3.541,2,1,4]
["S3938","Bisdemethoxycurcumin (BDMC)","b3","L6200-11","in 10mM DMSO","Apoptosis related","Apoptosis","Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.",308.33,"33171-05-0",{"v":62,"d":"62.00"},201.08,"<1","N/A","http://selleckchem.com/products/bisdemethoxycurcumin.html","C19H16O4","free base","N/A","OC1=CC=C(C=C1)/C=C/C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",3.587,2,2,6]
["S3940","3'-Hydroxypterostilbene","c3","L6200-11","in 10mM DMSO","ERK,JNK,p38 MAPK,S6 Kinase","MAPK","3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.",{"v":272.3,"d":"272.30"},"475231-21-1",{"v":54,"d":"54.00"},198.31,"<1","N/A","http://selleckchem.com/products/3-hydroxypterostilbene.html","C16H16O4","free base","3'-HPT","COC1=CC(=CC(=C1)/C=C/C2=CC(=C(O)C=C2)O)OC",3.299,2,2,4]
["S3941","Pinocembrin","d3","L6200-11","in 10mM DMSO","ADC Cytotoxin,Anti-infection","Microbiology","Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.",256.25,"480-39-7",{"v":51,"d":"51.00"},199.02,"<1","N/A","http://selleckchem.com/products/pinocembrin.html","C15H12O4","free base","Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone","OC1=CC2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O",2.615,2,2,1]
["S3944","Valproic acid (VPA)","e3","L6200-11","in 10mM DMSO","Autophagy,HDAC,Mitophagy,Notch,PGC-1α","Epigenetics","Valproic acid (VPA, 2-Propylvaleric Acid, Valproate) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Valproic acid activates Notch-1 signaling.",144.21,"99-66-1","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/valproic-acid.html","C8H16O2","free base","2-Propylvaleric Acid, Valproate","CCCC(CCC)C(O)=O",2.749,1,0,5]
["S3952","3,4-Dihydroxybenzaldehyde","f3","L6200-11","in 10mM DMSO","Others","Others","3,4-Dihydroxybenzaldehyde (Protocatechuic aldehyde) is a phenolic aldehyde, a precursor in vanillin synthesis via biotransformation by cell cultures of Capsicum frutescens, a type of chili pepper.",138.12,"139-85-5",{"v":27,"d":"27.00"},195.48,"N/A","N/A","http://selleckchem.com/products/3-4-dihydroxybenzaldehyde.html","C7H6O3","free base","protocatechuic aldehyde","OC1=CC=C(C=O)C=C1O",1.105,1,2,1]
["S3956","Tetramethylpyrazine","g3","L6200-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.",136.19,"1124-11-4",{"v":27,"d":"27.00"},198.25,"N/A","N/A","http://selleckchem.com/products/tetramethylpyrazine.html","C8H12N2","free base","ligustrazine","CC1=NC(=C(C)N=C1C)C",0.659,2,0,0]
["S3957","Gamma-Oryzanol","h3","L6200-11","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.  γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).",602.89,"11042-64-1",{"v":100,"d":"100.00"},165.87,"N/A","N/A","http://selleckchem.com/products/gamma-oryzanol.html","C40H58O4","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2CCC34CC35CCC6(C)C(CCC6(C)C5CCC4C2(C)C)C(C)CCC=C(C)C",9.806,3,1,9]
["S3967","Flavone","a4","L6200-11","in 10mM DMSO","Apoptosis related","Apoptosis","Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.",222.24,"525-82-6",{"v":44,"d":"44.00"},197.98,"N/A","N/A","http://selleckchem.com/products/flavone.html","C15H10O2","free base","2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron","O=C1C=C(OC2=C1C=CC=C2)C3=CC=CC=C3",3.136,2,0,1]
["S3969","Veratric acid","b4","L6200-11","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,PGES","Immunology & Inflammation","Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.",182.17,"93-07-2",{"v":36,"d":"36.00"},197.62,"N/A","N/A","http://selleckchem.com/products/veratric-acid.html","C9H10O4","free base","3,4-Dimethoxybenzoic acid","COC1=C(OC)C=C(C=C1)C(O)=O",1.426,3,0,3]
["S3970","Vindoline","c4","L6200-11","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly.",456.53,"2182-14-1",{"v":91,"d":"91.00"},199.33,"N/A","N/A","http://selleckchem.com/products/vindoline.html","C25H32N2O6","free base","N/A","CCC12C=CCN3CCC4(C(N(C)C5=C4C=CC(=C5)OC)C(O)(C1OC(C)=O)C(=O)OC)C23",1.935,5,0,6]
["S3974","(+)-Catechin hydrate","d4","L6200-11","in 10mM DMSO","COX","Immunology & Inflammation","(+)-Catechin hydrate is a plant derived polyphenolic anti-oxidants with phytotoxic properties. (+)-Catechin hydrate is a frequent component of traditional herbal remedies, such as Uncaria rhynchophylla.  (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.",290.27,"225937-10-0",{"v":58,"d":"58.00"},199.81,"N/A","N/A","http://selleckchem.com/products/catechin-hydrate.html","C15H14O6.xH2O","hydrate","N/A","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S3975","Protocatechuic acid","e4","L6200-11","in 10mM DMSO","Apoptosis related","Apoptosis","Protocatechuic acid (PCA, 3,4-Dihydroxybenzoic acid, Protocatechuate), a dihydroxybenzoic acid, is a type of widely distributed naturally occurring phenolic acid.",154.12,"99-50-3",{"v":30,"d":"30.00"},194.65,"N/A","N/A","http://selleckchem.com/products/protocatechuic-acid.html","C7H6O4","free base","3,4-Dihydroxybenzoic acid, Protocatechuate","OC(=O)C1=CC(=C(O)C=C1)O",0.975,1,2,1]
["S3980","Pyridoxine","f4","L6200-11","in 10mM DMSO","Vitamin","Metabolism","Pyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.",169.18,"65-23-6",{"v":33,"d":"33.00"},195.06,"N/A","N/A","http://selleckchem.com/products/pyridoxine.html","C8H11NO3","free base","Pyridoxol, Vitamin B6, Gravidox","CC1=NC=C(CO)C(=C1O)CO",{"v":-0.49,"d":"-0.490"},1,3,2]
["S3981","Sinapinic Acid","g4","L6200-11","in 10mM DMSO","ACE,HDAC","DNA Damage/DNA Repair","Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.",224.21,"530-59-6",{"v":44,"d":"44.00"},196.24,"<1","N/A","http://selleckchem.com/products/sinapinic-acid.html","C11H12O5","free base","Sinapic acid","COC1=C(O)C(=CC(=C1)\\C=C\\C(O)=O)OC",1.652,3,1,4]
["S3984","Nordihydroguaiaretic acid (NDGA)","h4","L6200-11","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase","Metabolism","Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.",302.36,"500-38-9",{"v":60,"d":"60.00"},198.44,"<1","N/A","http://selleckchem.com/products/nordihydroguaiaretic-acid.html","C18H22O4","free base","N/A","CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O",4.708,0,4,5]
["S3993","Ethyl Vanillate","a5","L6200-11","in 10mM DMSO","Dehydrogenase","Metabolism","Ethyl vanillin (Bourbonal, Ethylprotal), a vanillin analog, is a flavouring agent and a fungicidal agent that exhibits strong antioxidant activity. Ethyl Vanillate inhibits 17β-HSD2 with an IC50 1.3 µM.",{"v":196.2,"d":"196.20"},"617-05-0",{"v":39,"d":"39.00"},198.78,"N/A","N/A","http://selleckchem.com/products/ethylvanillate.html","C10H12O4","free base","Bourbonal, Ethylprotal","CCOC(=O)C1=CC(=C(O)C=C1)OC",1.775,3,1,4]
["S3996","Thioctic acid","b5","L6200-11","in 10mM DMSO","Others","Others","Thioctic acid (DL-α-Lipoic acid) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form., Thioctic acid (DL-α-Lipoic acid)是环状二硫抗氧化剂，可与其还原性二硫酚形式相互转换。",206.33,"1077-28-7",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/thioctic-acid.html","C8H14O2S2","free base","DL-α-Lipoic Acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S3998","(+)-α-Lipoic acid","c5","L6200-11","in 10mM DMSO","LTR,NF-κB","NF-κB","(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.",206.33,"1200-22-2",{"v":41,"d":"41.00"},198.71,"N/A","N/A","http://selleckchem.com/products/alpha-lipoic-acid.html","C8H14O2S2","free base","(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid","OC(=O)CCCCC1CCSS1",2.258,1,0,5]
["S4002","Sitagliptin phosphate monohydrate","d5","L6200-11","in 10mM DMSO","DPP","Metabolism","Sitagliptin phosphate monohydrate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.",523.32,"654671-77-9",{"v":100,"d":"100.00"},191.09,{"v":41,"d":"41.00"},78.35,"https://www.selleckchem.com/products/sitagliptin-phosphate-monohydrate.html","C16H15F6N5O.H3PO4.H2O","phosphate &monohydrate","MK-0431","O.NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F.O[P](O)(O)=O",1.254,3,1,5]
["S4003","Lithocholic acid","e5","L6200-11","in 10mM DMSO","FXR","Metabolism","Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.",376.57,"434-13-9",{"v":75,"d":"75.00"},199.17,"<1","N/A","http://selleckchem.com/products/lithocholic-acid.html","C24H40O3","free base","N/A","CC(CCC(O)=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C",5.184,1,1,4]
["S4011","Ampiroxicam","f5","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.",447.46,"99464-64-9",{"v":90,"d":"90.00"},201.14,"<1","N/A","http://selleckchem.com/products/ampiroxicam.html","C20H21N3O7S","free base","CP 65703","CCOC(=O)OC(C)OC1=C(N(C)[S](=O)(=O)C2=C1C=CC=C2)C(=O)NC3=NC=CC=C3",1.718,8,1,8]
["S4017","Allylthiourea","g5","L6200-11","in 10mM DMSO","ROS","Immunology & Inflammation","Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.",116.18,"109-57-9",{"v":23,"d":"23.00"},197.97,"<1","N/A","http://selleckchem.com/products/allylthiourea.html","C4H8N2S","free base","N/A","NC(=S)NCC=C",0.842,0,2,3]
["S4039","Methazolamide","h5","L6200-11","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.",236.27,"554-57-4",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://selleckchem.com/products/methazolamide.html","C5H8N4O3S2","free base","CL 8490","CN1N=C(SC1=NC(C)=O)[S](N)(=O)=O",{"v":0.03,"d":"0.030"},5,1,1]
["S4049","Valdecoxib","a6","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.",314.36,"181695-72-7",{"v":63,"d":"63.00"},200.41,"<1","N/A","http://selleckchem.com/products/valdecoxib.html","C16H14N2O3S","free base","N/A","CC1=C(C2=CC=C(C=C2)[S](N)(=O)=O)C(=NO1)C3=CC=CC=C3",{"v":2.6,"d":"2.600"},4,1,3]
["S4051","Nabumetone","b6","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.",228.29,"42924-53-8",{"v":46,"d":"46.00"},{"v":201.5,"d":"201.50"},"<1","N/A","http://selleckchem.com/products/nabumetone.html","C15H16O2","free base","BRL-14777","COC1=CC=C2C=C(CCC(C)=O)C=CC2=C1",2.943,2,0,4]
["S4054","Spironolactone","c6","L6200-11","in 10mM DMSO","Androgen Receptor","Endocrinology & Hormones","Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.",416.57,"52-01-7",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/spironolactone.html","C24H32O4S","free base","N/A","CC(=O)SC1CC2=CC(=O)CCC2(C)C3CCC4(C)C(CCC45CCC(=O)O5)C13",3.731,4,0,2]
["S4059","Sodium Nitroprusside Dihydrate","d6","L6200-11","in 10mM DMSO","Others","Others","Sodium Nitroprusside  Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.",297.95,"13755-38-9",{"v":60,"d":"60.00"},201.38,{"v":60,"d":"60.00"},201.38,"http://selleckchem.com/products/sodium-nitroprusside-dihydrate.html","C5H4FeN6Na2O3","Dihydrate","N/A","[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N",0.571,1,0,1]
["S4073","Sodium 4-Aminosalicylate","e6","L6200-11","in 10mM DMSO","NF-κB","NF-κB","Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.",211.15,"6018-19-5",{"v":42,"d":"42.00"},198.91,{"v":42,"d":"42.00"},198.91,"http://selleckchem.com/products/aminosalicylate-sodium.html","C7H7NO3.2H2O.Na","Sodium Salt","N/A","[Na+].NC1=CC(=C(C=C1)C([O-])=O)O",-1.003,0,2,1]
["S4078","Mefenamic Acid","f6","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.",241.29,"61-68-7",{"v":48,"d":"48.00"},198.93,"<1","N/A","http://selleckchem.com/products/mefenamic-acid.html","C15H15NO2","free base","CI 473, CN-35355","CC1=C(C)C(=CC=C1)NC2=CC=CC=C2C(O)=O",3.982,1,1,3]
["S4081","Sulfacetamide Sodium","g6","L6200-11","in 10mM DMSO","Anti-infection,Autophagy","Immunology & Inflammation","Sulfacetamide Sodium is an anti-biotic.",236.22,"127-56-0",{"v":19,"d":"19.00"},80.43,{"v":51,"d":"51.00"},{"v":215.9,"d":"215.90"},"http://selleckchem.com/products/sulfacetamide-sodium.html","C8H10N2O3S.Na","Sodium Salt","N/A","[Na+].CC(=O)[N-][S](=O)(=O)C1=CC=C(N)C=C1",-0.118,3,1,2]
["S4084","Lomerizine 2HCl","h6","L6200-11","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.",541.46,"101477-54-7",{"v":100,"d":"100.00"},184.69,"<1","N/A","http://selleckchem.com/products/lomerizine-hcl.html","C27H30F2N2O3.2HCl","Dihydrochloride","KB-2796","Cl.Cl.COC1=C(OC)C(=C(CN2CCN(CC2)C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C=C1)OC",6.182,3,0,8]
["S4098","Halcinonide","a7","L6200-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.",454.96,"3093-35-4",{"v":90,"d":"90.00"},197.82,"<1","N/A","http://selleckchem.com/products/halcinonide.html","C24H32ClFO5","free base","SQ-18566","CC1(C)OC2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)C2(O1)C(=O)CCl",2.384,4,1,2]
["S4100","Esmolol HCl","b7","L6200-11","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Esmolol (ASL8052) is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.",331.83,"81161-17-3",{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},{"v":66,"d":"66.00"},{"v":198.9,"d":"198.90"},"http://selleckchem.com/products/esmolol-hcl.html","C16H25NO4.HCl","Hydrochloride","ASL8052","Cl.COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1",{"v":2.36,"d":"2.360"},3,2,10]
["S4114","Triclabendazole","c7","L6200-11","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Triclabendazole (CGA-89317,tcbz) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.",359.66,"68786-66-3",{"v":72,"d":"72.00"},200.19,"<1","N/A","http://selleckchem.com/products/triclabendazole.html","C14H9Cl3N2OS","free base","CGA-89317,tcbz","CSC1=NC2=C([NH]1)C=C(Cl)C(=C2)OC3=C(Cl)C(=CC=C3)Cl",5.982,2,1,3]
["S4118","Histamine 2HCl","d7","L6200-11","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Histamine(Ceplene) is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.",184.07,"56-92-8",{"v":3,"d":"3.00"},{"v":16.3,"d":"16.30"},{"v":37,"d":"37.00"},201.01,"http://selleckchem.com/products/histamine-2hcl.html","C5H9N3.2HCl","Dihydrochloride","Ceplene","Cl.Cl.NCCC1=C[NH]C=N1",{"v":0.05,"d":"0.050"},1,2,2]
["S4119","Pefloxacin Mesylate Dihydrate","e7","L6200-11","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Pefloxacin Mesylate Dihydrate (1589 RB,Pefloxacinium mesylate dihydrate) is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.",465.49,"149676-40-4",{"v":9,"d":"9.00"},19.33,{"v":67,"d":"67.00"},143.93,"http://selleckchem.com/products/pefloxacin-mesylate-dihydrate.html","C17H20FN3O3.CH4O3S.2H2O","Mesylate","1589 RB,Pefloxacinium mesylate dihydrate","O.O.CCN1C=C(C(O)=O)C(=O)C2=C1C=C(N3CCN(C)CC3)C(=C2)F.C[S](O)(=O)=O",-2.033,2,0,3]
["S4125","Sodium Phenylbutyrate","f7","L6200-11","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.",187.19,"1716-12-7",{"v":8,"d":"8.00"},42.97,{"v":30,"d":"30.00"},161.13,"http://selleckchem.com/products/sodium-phenylbutyrate.html","C10H11O2.Na","Sodium Salt","4-PBA, 4-Phenylbutyric acid, NaPB","[Na]OC(=O)CCCC1=CC=CC=C1",2.497,2,0,5]
["S4128","Troxipide","g7","L6200-11","in 10mM DMSO","Others","Others","Troxipide(KU 54) is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum.",294.35,"30751-05-4",{"v":18,"d":"18.00"},61.15,"<1","N/A","http://selleckchem.com/products/troxipide.html","C15H22N2O4","free base","KU 54","COC1=C(OC)C(=CC(=C1)C(=O)NC2CCCNC2)OC",1.081,4,2,5]
["S4132","Deoxyarbutin","h7","L6200-11","in 10mM DMSO","Tyrosinase","Proteases","DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.",194.23,"53936-56-4",{"v":39,"d":"39.00"},200.79,"<1","N/A","http://selleckchem.com/products/deoxyarbutin.html","C11H14O3","free base","D-arbutin,D-Arb","OC1=CC=C(OC2CCCCO2)C=C1",2.298,2,1,2]
["S4136","Carprofen","a8","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Carprofen inhibits canine COX2 with IC50 of 30 nM.",273.71,"53716-49-7",{"v":55,"d":"55.00"},200.94,"<1","N/A","http://selleckchem.com/products/carprofen.html","C15H12ClNO2","free base","N/A","CC(C(O)=O)C1=CC2=C(C=C1)C3=C([NH]2)C=CC(=C3)Cl",4.114,1,1,2]
["S4149","Amfenac Sodium Monohydrate","b8","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.",295.27,"61618-27-7",{"v":59,"d":"59.00"},199.82,{"v":59,"d":"59.00"},199.82,"http://selleckchem.com/products/amfenac-sodium-monohydrate.html","C15H12NO3.H2O.Na","free base","N/A","O.[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=CC=C2",{"v":0.47,"d":"0.470"},1,1,4]
["S4151","Penfluridol","c8","L6200-11","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.",523.97,"26864-56-2",{"v":100,"d":"100.00"},190.85,"<1","N/A","http://selleckchem.com/products/penfluridol.html","C28H27ClF5NO","free base","TLP-607,R-16341","OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(=C(Cl)C=C4)C(F)(F)F",7.311,0,0,8]
["S4155","Chlorzoxazone","d8","L6200-11","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.",169.57,"95-25-0",{"v":34,"d":"34.00"},200.51,"<1","N/A","http://selleckchem.com/products/chlorzoxazone.html","C7H4ClNO2","free base","Chlorzoxazon,Paraflex","ClC1=CC2=C(OC(=O)N2)C=C1",2.004,2,1,0]
["S4159","Bezafibrate","e8","L6200-11","in 10mM DMSO","PPAR","Metabolism","Bezafibrate (BM 15075) is the first clinically tested dual and pan-PPAR co-agonism.",361.82,"41859-67-0",{"v":72,"d":"72.00"},198.99,"<1","N/A","http://selleckchem.com/products/bezafibrate.html","C19H20ClNO4","free base","BM 15075","CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O",3.868,3,1,7]
["S4163","Doxycycline Hyclate (WC2031)","f8","L6200-11","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,MMP","Proteases","Doxycycline Hyclate (WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate) is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP).",512.94,"24390-14-5",{"v":100,"d":"100.00"},194.95,{"v":100,"d":"100.00"},194.95,"http://selleckchem.com/products/doxycycline-hyclate.html","C22H24N2O8.1/2C2H6O.HCl.1/2H2O","hyclate","Doxycycline hydrochloride hemiethanolate hemihydrate","O.Cl.Cl.CCO.CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C(O)C=CC=C14)O)O.CC5C6C(O)C7C(N(C)C)C(=C(C(N)=O)C(=O)C7(O)C(=C6C(=O)C8=C(O)C=CC=C58)O)O",-0.955,6,11,4]
["S4176","Trometamol","g8","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Trometamol(Tromethamine) is a proton acceptor used to treat acidemia.",121.14,"77-86-1",{"v":2,"d":"2.00"},16.51,{"v":24,"d":"24.00"},198.12,"http://selleckchem.com/products/trometamol.html","C4H11NO3","free base","Tromethamine","NC(CO)(CO)CO",-2.381,0,4,3]
["S4181","Nicardipine HCl","h8","L6200-11","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.",515.99,"54527-84-3",{"v":100,"d":"100.00"},{"v":193.8,"d":"193.80"},"<1","N/A","http://selleckchem.com/products/nicardipine-hcl.html","C26H29N3O6.HCl","Hydrochloride","RS-69216,YC-93","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",{"v":3.87,"d":"3.870"},4,1,11]
["S4182","Nifuroxazide","a9","L6200-11","in 10mM DMSO","STAT","JAK/STAT","Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.",275.22,"965-52-6",{"v":55,"d":"55.00"},199.84,"<1","N/A","http://selleckchem.com/products/nifuroxazide.html","C12H9N3O5","free base","N/A","OC1=CC=C(C=C1)C(=O)N/N=C/C2=CC=C(O2)[N+]([O-])=O",1.855,3,2,4]
["S4188","Sasapyrine","b9","L6200-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sasapyrine (Salsalate, NSC-49171) is a nonsteroidal oral anti-inflammatory agent.",258.23,"552-94-3",{"v":52,"d":"52.00"},201.37,"<1","N/A","http://selleckchem.com/products/sasapyrine.html","C14H10O5","free base","NSC-49171,Salsalate","OC(=O)C1=CC=CC=C1OC(=O)C2=CC=CC=C2O",2.649,3,1,4]
["S4194","Azaguanine-8","c9","L6200-11","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.",152.11,"134-58-7",{"v":6,"d":"6.00"},39.45,"<1","N/A","http://selleckchem.com/products/azaguanine-8.html","C4H4N6O","free base","NSC-749, SF-337, SK 1150","NC1=NC2=C(N=N[NH]2)C(=O)N1",-0.852,4,3,0]
["S4198","Aminothiazole","d9","L6200-11","in 10mM DMSO","Bacterial","Microbiology","Aminothiazole(2-Aminothiazole,2-Thiazolylamine) can be used as a thyroid inhibitor and it has antibacterial activity.",100.14,"96-50-4",{"v":20,"d":"20.00"},199.72,{"v":20,"d":"20.00"},199.72,"http://selleckchem.com/products/aminothiazole.html","C3H4N2S","free base","2-Aminothiazole,2-Thiazolylamine","NC1=NC=CS1",{"v":0.08,"d":"0.080"},1,1,0]
["S4202","Verapamil (CP-16533-1) HCl","e9","L6200-11","in 10mM DMSO","Calcium Channel,P450 (e.g. CYP17),P-gp","Transmembrane Transporters","Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.",491.06,"152-11-4",{"v":98,"d":"98.00"},199.57,{"v":50,"d":"50.00"},101.82,"http://selleckchem.com/products/verapami-hcl.html","C27H38N2O4.HCl","Hydrochloride","(±)-Verapamil hydrochloride","Cl.COC1=CC=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC=C(OC)C(=C2)OC)C=C1OC",5.916,4,0,13]
["S4206","Cysteamine HCl","f9","L6200-11","in 10mM DMSO","Antioxidant","Metabolism","Cysteamine HCl(Mercaptamine) is an autophagy-stimulatory proteostasis regulator. Cysteamine can be used for the treatment of nephropathic cystinosis and an antioxidant.",113.61,"156-57-0",{"v":23,"d":"23.00"},202.45,{"v":23,"d":"23.00"},202.45,"http://selleckchem.com/products/cysteamine-hcl.html","C2H7NS.HCl","Hydrochloride","Mercaptamine","Cl.NCCS",0.166,0,1,1]
["S4207","Clofibric Acid","g9","L6200-11","in 10mM DMSO","PPAR","Metabolism","Clofibric acid(Chlorofibrinic acid) is a PPARα agonist and hypolipidemic agent.",214.65,"882-09-7",{"v":43,"d":"43.00"},200.33,"<1","N/A","http://selleckchem.com/products/clofibric-acid.html","C10H11ClO3","free base","Chlorofibrinic acid","CC(C)(OC1=CC=C(Cl)C=C1)C(O)=O",2.755,2,0,3]
["S4221","Benzbromarone","h9","L6200-11","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Benzbromarone(Desuric) is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.",424.08,"3562-84-3",{"v":85,"d":"85.00"},200.43,"<1","N/A","http://selleckchem.com/products/benzbromarone.html","C17H12Br2O3","free base","Desuric","CCC1=C(C(=O)C2=CC(=C(O)C(=C2)Br)Br)C3=C(O1)C=CC=C3",5.604,2,1,3]
["S4223","Mevastatin","a10","L6200-11","in 10mM DMSO","HMG-CoA Reductase","Metabolism","Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.",390.51,"73573-88-3",{"v":78,"d":"78.00"},199.74,"<1","N/A","http://selleckchem.com/products/mevastatin.html","C23H34O5","free base","ML-236B,Compactin","CCC(C)C(=O)OC1CCC=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12",3.966,4,1,7]
["S4227","Fidaxomicin","b10","L6200-11","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Fidaxomicin (OPT-80, PAR-101,Dificid) is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.",1058.04,"873857-62-6",{"v":100,"d":"100.00"},94.51,"<1","N/A","http://selleckchem.com/products/fidaxomicin.html","C52H74Cl2O18","free base","OPT-80, PAR-101,Dificid","CCC1\\C=C(C)/C(O)C\\C=C\\C=C(COC2OC(C)C(OC(=O)C3=C(CC)C(=C(O)C(=C3O)Cl)Cl)C(O)C2OC)\\C(=O)OC(C\\C=C(C)\\C=C(C)\\C1OC4OC(C)(C)C(OC(=O)C(C)C)C(O)C4O)C(C)O",7.774,11,7,15]
["S4230","Oxaprozin","c10","L6200-11","in 10mM DMSO","COX","Metabolism","Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.",293.32,"21256-18-8",{"v":59,"d":"59.00"},201.15,"<1","N/A","http://selleckchem.com/products/oxaprozin.html","C18H15NO3","free base","WY-21743,nsc 310839","OC(=O)CCC1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3",{"v":3.59,"d":"3.590"},3,0,5]
["S4238","Cepharanthine","d10","L6200-11","in 10mM DMSO","TNF-alpha","Apoptosis","Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.",606.71,"481-49-2",{"v":100,"d":"100.00"},164.82,"<1","N/A","http://selleckchem.com/products/cepharanthine.html","C37H38N2O6","free base","NSC-623442","COC1=C2OC3=CC=C(CC4N(C)CCC5=C4C(=C6OCOC6=C5)OC7=C(OC)C=C8CCN(C)C(CC(=C2)C=C1)C8=C7)C=C3",7.019,6,0,2]
["S4239","Bergapten","e10","L6200-11","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.",216.19,"484-20-8",{"v":5,"d":"5.00"},23.13,"<1","N/A","http://selleckchem.com/products/bergapten.html","C12H8O4","free base","N/A","COC1=C2C=COC2=CC3=C1C=CC(=O)O3",2.187,4,0,1]
["S4246","Tranylcypromine (2-PCPA) HCl","f10","L6200-11","in 10mM DMSO","MAO","Metabolism","Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.",169.65,"1986-47-6",{"v":33,"d":"33.00"},194.52,{"v":33,"d":"33.00"},194.52,"http://selleckchem.com/products/tranylcypromine-2-pcpa-hcl.html","C9H12ClN","Hydrochloride","SKF-385 HCl, Parnate,2-PCPA","Cl.NC1CC1C2=CC=CC=C2",2.309,0,1,1]
["S4248","Bromfenac Sodium","g10","L6200-11","in 10mM DMSO","COX","Neuronal Signaling","Bromfenac Sodium (AHR 10282R,Bromsite,Bromday,Prolensa,Xibrom) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.",356.15,"91714-93-1",{"v":71,"d":"71.00"},199.35,{"v":71,"d":"71.00"},199.35,"http://selleckchem.com/products/bromfenac-sodium.html","C15H11BrNO3.Na","Sodium Salt","AHR 10282R,Bromsite,Bromday,Prolensa,Xibrom","[Na+].NC1=C(C=CC=C1CC([O-])=O)C(=O)C2=CC=C(Br)C=C2",1.426,1,1,4]
["S4255","Quinacrine 2HCl","h10","L6200-11","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective  phospholipase A2 inhibitor.",472.88,"69-05-6",{"v":14,"d":"14.00"},29.61,{"v":53,"d":"53.00"},112.08,"http://selleckchem.com/products/quinacrine-2hcl.html","C23H30ClN3O.2HCl","Dihydrochloride","Quinacrine dihydrochloride","Cl.Cl.CCN(CC)CCCC(C)NC1=C2C=C(OC)C=CC2=NC3=CC(=CC=C13)Cl",{"v":6.43,"d":"6.430"},2,1,9]
["S4261","EUK 134","a11","L6200-11","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.",416.74,"81065-76-1",{"v":83,"d":"83.00"},199.16,{"v":13,"d":"13.00"},31.19,"http://selleckchem.com/products/euk-134.html","C18H18ClMnN2O4","Complex","N/A","COC1=C2O[Mn]|3|4(Cl)OC5=C(OC)C=CC=C5C=N|3CCN|4=CC2=CC=C1",3.526,4,0,2]
["S4263","Efaproxiral Sodium","b11","L6200-11","in 10mM DMSO","ROS","Immunology & Inflammation","Efaproxiral Sodium(RSR13 Sodium) is a synthetic allosteric modifier of hemoglobin, decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy. Efaproxiral Sodium is used for brain metastases originating from breast cancer.",363.38,"170787-99-2",{"v":73,"d":"73.00"},200.89,{"v":73,"d":"73.00"},200.89,"http://selleckchem.com/products/efaproxiral-sodium.html","C20H23NO4.Na","Sodium salt","RSR13 Sodium","[Na+].CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(OC(C)(C)C([O-])=O)C=C2)C",2.408,2,1,6]
["S4268","Flufenamic acid","c11","L6200-11","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.",281.23,"530-78-9",{"v":56,"d":"56.00"},199.13,"<1","N/A","http://selleckchem.com/products/flufenamic-acid.html","C14H10F3NO2","free base","N/A","OC(=O)C1=CC=CC=C1NC2=CC=CC(=C2)C(F)(F)F",3.952,1,1,4]
["S4269","Vinorelbine ditartrate (KW-2307)","d11","L6200-11","in 10mM DMSO","Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.",1079.11,"125317-39-7",{"v":100,"d":"100.00"},92.67,{"v":100,"d":"100.00"},92.67,"http://selleckchem.com/products/vinorelbine-tartrate.html","C45H54N4O8.2C4H6O6","ditartrate","Nor-5'-anhydrovinblastine ditartrate,KW-2307","CCC1=CC2CN(C1)CC3=C([NH]C4=C3C=CC=C4)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC.OC(C(O)C(O)=O)C(O)=O.OC(C(O)C(O)=O)C(O)=O",{"v":-4,"d":"-4.000"},11,5,16]
["S4280","Meclofenoxate (Centrophenoxine) HCl","e11","L6200-11","in 10mM DMSO","Transferase","Metabolism","Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.",294.17,"3685-84-5",{"v":58,"d":"58.00"},197.16,{"v":58,"d":"58.00"},197.16,"http://selleckchem.com/products/meclofenoxate-centrophenoxine-hci.html","C12H17Cl2NO3","Hydrochloride","Centrophenoxine","Cl.CN(C)CCOC(=O)COC1=CC=C(Cl)C=C1",2.705,3,0,7]
["S4282","Nelfinavir (AG 1343) Mesylate","f11","L6200-11","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Nelfinavir Mesylate (Viracept, AG1343) is a potent HIV protease inhibitor with Ki of 2 nM.",663.89,"159989-65-8",{"v":100,"d":"100.00"},150.63,"<1","N/A","http://selleckchem.com/products/nelfinavir-mesylate.html","C33H49N3O7S2","Mesylate","Viracept, AG1343","CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(O)CN3CC4CCCCC4CC3C(=O)NC(C)(C)C.C[S](O)(=O)=O",4.871,2,4,10]
["S4288","Chloroambucil","g11","L6200-11","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Chloroambucil (Chlorambucil,CB-1348,WR-139013) is a nitrogen mustard alkylating agent, used in the treatment of chronic lymphocytic leukemia.",304.21,"305-03-3",{"v":60,"d":"60.00"},197.23,"<1","N/A","http://selleckchem.com/products/chloroambucil.html","C14H19Cl2NO2","free base","Chlorambucil,CB-1348,WR-139013","OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl",3.899,1,0,9]
["S4294","Procainamide HCl","h11","L6200-11","in 10mM DMSO","DNA Methyltransferase,Sodium Channel","Transmembrane Transporters","Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.",271.79,"614-39-1",{"v":54,"d":"54.00"},198.68,{"v":54,"d":"54.00"},198.68,"http://selleckchem.com/products/procainamide-hcl.html","C13H22ClN3O","Hydrochloride","N/A","Cl.CCN(CC)CCNC(=O)C1=CC=C(N)C=C1",1.509,1,2,6]
["S4295","Meclofenamate Sodium","a2","L6200-12","in 10mM DMSO","COX,FTO","Neuronal Signaling","Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.",318.13,"6385-02-0",{"v":63,"d":"63.00"},198.03,{"v":63,"d":"63.00"},198.03,"http://selleckchem.com/products/meclofenamate-sodium.html","C14H11Cl2NO2.Na","Sodium Salt","CI 583","CC1=C(Cl)C(=C(Cl)C=C1)NC2=CC=CC=C2C(=O)O[Na]",4.915,2,1,4]
["S4297","Mupirocin","b2","L6200-12","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Mupirocin(BRL-4910A,Pseudomonic acid) is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.",500.62,"12650-69-0",{"v":100,"d":"100.00"},199.75,{"v":46,"d":"46.00"},91.89,"http://selleckchem.com/products/mupirocin.html","C26H44O9","free base","BRL-4910A,Pseudomonic acid","CC(O)C(C)C1OC1CC2COC(C\\C(C)=C\\C(=O)OCCCCCCCCC(O)=O)C(O)C2O",2.739,5,3,17]
["S4309","Bromocriptine Mesylate","c2","L6200-12","in 10mM DMSO","Others","Others","Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.",{"v":750.7,"d":"750.70"},"22260-51-1",{"v":100,"d":"100.00"},133.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bromocriptine-mesylate.html","C32H40BrN5O5.CH4O3S","Mesylate","N/A","CC(C)CC1N2C(=O)C(NC(=O)C3CN(C)C4CC5=C(Br)[NH]C6=C5C(=CC=C6)C4=C3)(OC2(O)C7CCCN7C1=O)C(C)C.C[S](O)(=O)=O",3.949,4,2,5]
["S4345","Pentoxifylline","d2","L6200-12","in 10mM DMSO","PDE","Metabolism","Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.",278.31,"6493-05-6",{"v":55,"d":"55.00"},197.62,{"v":55,"d":"55.00"},197.62,"http://www.selleckchem.com/products/pentoxifylline.html","C13H18N4O3","Free Base","N/A","C[N]1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C",0.507,4,0,5]
["S4353","Terfenadine","e2","L6200-12","in 10mM DMSO","Calcium Channel,Caspase,Histamine Receptor,NCX,Potassium Channel","Transmembrane Transporters","Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.  Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.",471.67,"50679-08-8",{"v":94,"d":"94.00"},199.29,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/terfenadine.html","C32H41NO2","Free Base","N/A","CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",6.498,0,1,9]
["S4358","Pimozide","f2","L6200-12","in 10mM DMSO","5-HT Receptor,Adrenergic Receptor,Dopamine Receptor,STAT","Neuronal Signaling","Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.",461.55,"2062-78-4",{"v":92,"d":"92.00"},199.33,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pimozide.html","C28H29F2N3O","Free Base","Orap, R6238","FC1=CC=C(C=C1)C(CCCN2CCC(CC2)N3C(=O)NC4=CC=CC=C34)C5=CC=C(F)C=C5",5.521,1,1,7]
["S4381","Proadifen HCl","g2","L6200-12","in 10mM DMSO","CYP450","Others","Proadifen is an inhibitor of cytochrome P450 enzymes, preventing some types of drug metabolism.",390.01,"62-68-0",{"v":77,"d":"77.00"},197.43,{"v":77,"d":"77.00"},197.43,"http://www.selleckchem.com/products/proadifen-hcl.html","C23H32ClNO2","hydrochloride","SKF 525-A HCl","Cl.CCCC(C(=O)OCCN(CC)CC)(C1=CC=CC=C1)C2=CC=CC=C2",5.762,2,0,11]
["S4398","Isoxicam","h2","L6200-12","in 10mM DMSO","Others","Others","N/A",335.34,"34552-84-6",{"v":17,"d":"17.00"},50.69,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/isoxicam.html","C14H13N3O5S","Free Base","N/A","CN1C(=C(O)C2=CC=CC=C2[S]1(=O)=O)C(=O)NC3=NOC(=C3)C",0.251,5,2,2]
["S4420","Mefloquine HCl","a3","L6200-12","in 10mM DMSO","Anti-infection","Microbiology","Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.",414.77,"51773-92-3",{"v":82,"d":"82.00"},{"v":197.7,"d":"197.70"},"<1","N/A","http://selleckchem.com/products/mefloquine-hcl.html","C17H17ClF6N2O","Hydrochloride","Mefloquin hydrochloride","Cl.OC(C1CCCCN1)C2=CC(=NC3=C(C=CC=C23)C(F)(F)F)C(F)(F)F",4.684,1,2,4]
["S4504","6-Mercaptopurine (6-MP) Monohydrate","b3","L6200-12","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","6-Mercaptopurine (6-MP) Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.",170.19,"6112-76-1",{"v":34,"d":"34.00"},199.78,"<1","N/A","http://selleckchem.com/products/6-mercaptopurine-6-mp-monohydrate.html","C5H6N4OS","free base","N/A","O.S=C1N=CNC2=C1[NH]C=N2",{"v":0.16,"d":"0.160"},2,2,0]
["S4505","Vinblastine (NSC-49842) sulfate","c3","L6200-12","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1","N/A","http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4506","Acetazolamide","d3","L6200-12","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).",222.25,"59-66-5",{"v":44,"d":"44.00"},197.98,"<1","N/A","http://selleckchem.com/products/acetazolamide.html","C4H6N4O3S2","free base","Diamox","CC(=O)NC1=NN=C(S1)[S](N)(=O)=O",-1.329,5,2,2]
["S4509","4-Aminoantipyrine","e3","L6200-12","in 10mM DMSO","COX","Immunology & Inflammation","4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.",203.24,"83-07-8",{"v":40,"d":"40.00"},196.81,{"v":40,"d":"40.00"},196.81,"http://selleckchem.com/products/4-aminoantipyrine.html","C11H13N3O","free base","Ampyrone, NSC 60242, Metapirazone, Solnapyrin-A, Solvapyrin-A,  Minoazophene, Aminoazophene,  Aminoantipyrin","CN1N(C2=CC=CC=C2)C(=O)C(=C1C)N",0.021,1,1,1]
["S4511","6-Benzylaminopurine","f3","L6200-12","in 10mM DMSO","ROS","Immunology & Inflammation","6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development.",225.25,"1214-39-7",{"v":45,"d":"45.00"},199.78,"<1","N/A","http://selleckchem.com/products/6-benzylaminopurine.html","C12H11N5","free base","N/A","C(NC1=NC=NC2=C1[NH]C=N2)C3=CC=CC=C3",1.693,3,2,3]
["S4512","Aceglutamide","g3","L6200-12","in 10mM DMSO","Others","Others","Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability.",188.18,"2490-97-3",{"v":37,"d":"37.00"},196.62,{"v":37,"d":"37.00"},196.62,"http://selleckchem.com/products/aceglutamide.html","C7H12N2O4","free base","α-N-Acetyl-L-glutamine, N2-Acetylglutamine","CC(=O)NC(CCC(N)=O)C(O)=O",-1.587,3,2,5]
["S4526","Fenbufen","h3","L6200-12","in 10mM DMSO","COX","Neuronal Signaling","Fenbufen (Lederfen, CL-82204) is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.",254.28,"36330-85-5",{"v":50,"d":"50.00"},196.63,"<1","N/A","http://selleckchem.com/products/fenbufen.html","C16H14O3","free base","Lederfen, CL-82204","OC(=O)CCC(=O)C1=CC=C(C=C1)C2=CC=CC=C2",2.933,2,0,5]
["S4527","Fenofibric acid","a4","L6200-12","in 10mM DMSO","PPAR","Metabolism","Fenofibric acid (NSC 281318, Trilipix, FNF acid) is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.",318.75,"42017-89-0",{"v":63,"d":"63.00"},197.65,{"v":63,"d":"63.00"},197.65,"http://selleckchem.com/products/fenofibric-acid.html","C17H15ClO4","free base","NSC 281318, Trilipix, FNF acid","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C(O)=O",4.159,3,0,5]
["S4539","Salicylic acid","b4","L6200-12","in 10mM DMSO","COX","Neuronal Signaling","Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.",138.12,"69-72-7",{"v":27,"d":"27.00"},195.48,"<1","N/A","http://selleckchem.com/products/salicylic-acid.html","C7H6O3","free base","2-Hydroxybenzoic acid","OC(=O)C1=C(O)C=CC=C1",1.217,1,1,1]
["S4541","Triclosan","c4","L6200-12","in 10mM DMSO","Bacterial","Microbiology","Triclosan (Irgasan, Cloxifenolum) is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.",289.54,"3380-34-5",{"v":57,"d":"57.00"},196.86,"<1","N/A","http://selleckchem.com/products/triclosan.html","C12H7Cl3O2","free base","Irgasan, Cloxifenolum","OC1=CC(=CC=C1OC2=CC=C(Cl)C=C2Cl)Cl",5.141,1,1,2]
["S4543","Trimetazidine dihydrochloride","d4","L6200-12","in 10mM DMSO","FAO","Metabolism","Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.",339.26,"13171-25-0",{"v":67,"d":"67.00"},197.49,{"v":67,"d":"67.00"},197.49,"http://selleckchem.com/products/trimetazidine-dihydrochloride.html","C14H22N2O3.2HCl","Dihydrochloride","Yoshimilon, Kyurinett, Vastarel F","Cl.Cl.COC1=C(OC)C(=C(CN2CCNCC2)C=C1)OC",2.039,3,1,5]
["S4546","Xylitol","e4","L6200-12","in 10mM DMSO","Autophagy","Autophagy","Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.",152.15,"87-99-0",{"v":30,"d":"30.00"},197.17,{"v":30,"d":"30.00"},197.17,"http://selleckchem.com/products/xylitol.html","C5H12O5","free base","Adonitol, Ribitol, Xylite, D-Xylitol, Adonite","OCC(O)C(O)C(O)CO",{"v":-2.43,"d":"-2.430"},0,5,4]
["S4548","Aminoguanidine hydrochloride","f4","L6200-12","in 10mM DMSO","NOS","Immunology & Inflammation","Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.",110.55,"1937-19-5",{"v":22,"d":"22.00"},{"v":199,"d":"199.00"},{"v":22,"d":"22.00"},{"v":199,"d":"199.00"},"http://selleckchem.com/products/aminoguanidine-hydrochloride.html","CH6N4.HCl","hydrochloride","Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine","Cl.NNC(N)=N",-1.098,0,3,1]
["S4559","Cloxiquine","g4","L6200-12","in 10mM DMSO","Fungal","Microbiology","Cloxiquine (5-Chloro-8-quinolinol, Dermofungin) is an antibacterial, antifungal, antiaging and antituberculosis drug.",{"v":179.6,"d":"179.60"},"130-16-5",{"v":35,"d":"35.00"},194.88,"<1","N/A","http://selleckchem.com/products/cloxiquine.html","C9H6ClNO","free base","5-Chloro-8-quinolinol, Dermofungin","OC1=CC=C(Cl)C2=CC=CN=C12",2.438,1,1,0]
["S4561","Danthron","h4","L6200-12","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.",240.21,"117-10-2",{"v":4,"d":"4.00"},16.65,"<1","N/A","http://selleckchem.com/products/danthron.html","C14H8O4","free base","chrysazin, Antrapurol","OC1=CC=CC2=C1C(=O)C3=C(O)C=CC=C3C2=O",2.324,2,2,0]
["S4571","Hexylresorcinol","a5","L6200-12","in 10mM DMSO","Tyrosinase","Proteases","Hexylresorcinol (4-Hexylresorcinol) is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase. The IC50 values of hexylresorcinol for monophenolase is 1.24 μM and for diphenolase is 0.85 μM.",194.27,"136-77-6",{"v":38,"d":"38.00"},{"v":195.6,"d":"195.60"},"<1","N/A","http://selleckchem.com/products/hexylresorcinol.html","C12H18O2","free base","4-Hexylresorcinol","CCCCCCC1=C(O)C=C(O)C=C1",4.113,0,2,5]
["S4576","Sulfabenzamide","b5","L6200-12","in 10mM DMSO","Bacterial","Microbiology","Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.",276.31,"127-71-9",{"v":55,"d":"55.00"},199.05,"<1","N/A","http://selleckchem.com/products/sulfabenzamide.html","C13H12N2O3S","free base","Sultrin, N-Sulfanilylbenzamide","NC1=CC=C(C=C1)[S](=O)(=O)NC(=O)C2=CC=CC=C2",1.442,3,2,3]
["S4589","Amodiaquine dihydrochloride dihydrate","c5","L6200-12","in 10mM DMSO","Histone Methyltransferase,HNMT,Transferase","Epigenetics","Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.",464.81,"6398-98-7",{"v":92,"d":"92.00"},197.93,{"v":29,"d":"29.00"},62.39,"http://selleckchem.com/products/amodiaquine-dihydrochloride-dihydrate.html","C20H22ClN3O.2HCl.2H2O","dihydrochloride dihydrate","N/A","O.O.Cl.Cl.CCN(CC)CC1=CC(=CC=C1O)NC2=C3C=CC(=CC3=NC=C2)Cl",5.109,1,2,6]
["S4591","Nitroxoline","d5","L6200-12","in 10mM DMSO","Cathepsin B,Cysteine Protease","Proteases","Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity.",190.16,"4008-48-4",{"v":38,"d":"38.00"},199.83,"<1","N/A","http://selleckchem.com/products/nitroxoline.html","C9H6N2O3","free base","8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline","OC1=CC=C(C2=CC=CN=C12)[N+]([O-])=O",1.668,1,1,1]
["S4601","Clioquinol","e5","L6200-12","in 10mM DMSO","Fungal","Microbiology","Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.",{"v":305.5,"d":"305.50"},"130-26-7",{"v":61,"d":"61.00"},199.67,"<1","N/A","http://selleckchem.com/products/5-chloro-8-hydroxy-7-iodoquinoline.html","C9H5ClINO","free base","Iodochlorhydroxyquin, Chinoform","OC1=C(I)C=C(Cl)C2=CC=CN=C12",3.016,1,1,0]
["S4603","Gallic acid","f5","L6200-12","in 10mM DMSO","ROS","Immunology & Inflammation","Gallic acid (3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid), known as powerful antioxidants, is an organic acid found in a variety of foods and herbs.",170.12,"149-91-7",{"v":34,"d":"34.00"},199.86,{"v":7,"d":"7.00"},41.15,"http://selleckchem.com/products/gallic-acid.html","C7H6O5","free base","3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid","OC(=O)C1=CC(=C(O)C(=C1)O)O",0.733,1,3,1]
["S4604","Levofloxacin hydrate","g5","L6200-12","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Levofloxacin (Levaquin, Tavanic, Quixin, Iquix, Cravit) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).",370.38,"138199-71-0",{"v":74,"d":"74.00"},199.79,{"v":5,"d":"5.00"},{"v":13.5,"d":"13.50"},"http://selleckchem.com/products/levofloxacin-hydrate.html","C18H20FN3O4.1/2H2O","hydrate","Levofloxacin hemihydrate, Levaquin hydrate, Tavanic hydrate, Quixin hydrate, Iquix hydrate, Cravit hydrate","CC1COC2=C3N1C=C(C(O)=O)C(=O)C3=CC(=C2N4CCN(C)CC4)F",{"v":-0.64,"d":"-0.640"},3,0,2]
["S4609","Diflunisal","h5","L6200-12","in 10mM DMSO","COX","Neuronal Signaling","Diflunisal (Dolobid, Dolobis, Flovacil, Fluniget,MK-647) is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.",{"v":250.2,"d":"250.20"},"22494-42-4",{"v":50,"d":"50.00"},199.84,"<1","N/A","http://selleckchem.com/products/diflunisal.html","C13H8F2O3","free base","Dolobid, Dolobis, Flovacil, Fluniget,MK-647","OC(=O)C1=C(O)C=CC(=C1)C2=C(F)C=C(F)C=C2",3.147,1,1,2]
["S4612","Dapson","a6","L6200-12","in 10mM DMSO","Antibiotics","Microbiology","Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.",{"v":248.3,"d":"248.30"},"80-08-0",{"v":49,"d":"49.00"},197.34,"<1","N/A","http://selleckchem.com/products/dapson.html","C12H12N2O2S","free base","Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS","NC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(N)C=C2",1.439,2,2,2]
["S4628","(+/-)-Sulfinpyrazone","b6","L6200-12","in 10mM DMSO","COX","Neuronal Signaling","Sulfinpyrazone (G-28315, NSC 75925) is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.",404.48,"57-96-5",{"v":80,"d":"80.00"},197.78,"<1","N/A","http://selleckchem.com/products/sulfinpyrazone.html","C23H20N2O3S","free base","G-28315, NSC 75925","O=C1C(CC[S](=O)C2=CC=CC=C2)C(=O)N(N1C3=CC=CC=C3)C4=CC=CC=C4",3.434,3,0,6]
["S4630","Diazoxide","c6","L6200-12","in 10mM DMSO","ADC Cytotoxin,Potassium Channel","Transmembrane Transporters","Diazoxide (Sch-6783, SRG-95213, Proglycem) is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.",230.67,"364-98-7",{"v":46,"d":"46.00"},199.42,"<1","N/A","http://selleckchem.com/products/diazoxide.html","C8H7ClN2O2S","free base","Sch-6783, SRG-95213, Proglycem","CC1=NC2=CC=C(Cl)C=C2[S](=O)(=O)N1",1.196,3,1,0]
["S4636","Teneligliptin hydrobromide","d6","L6200-12","in 10mM DMSO","DPP","Proteases","Teneligliptin (Teneligliptin hydrobromide anhydrous) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.",628.86,"906093-29-6",{"v":100,"d":"100.00"},159.02,{"v":100,"d":"100.00"},159.02,"http://selleckchem.com/products/teneligliptin-hydrobromide.html","C22H30N6OS.5/2HBr","hydrobromide","Teneligliptin hydrobromide anhydrous","CC1=N[N](C2=CC=CC=C2)C(=C1)N3CCN(CC3)C4CNC(C4)C(=O)N5CCSC5",2.645,2,1,4]
["S4640","Lesinurad","e6","L6200-12","in 10mM DMSO","OAT","Transmembrane Transporters","Lesinurad (RDEA-594) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in combination with xanthine oxidase inhibitors. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.",404.28,"878672-00-5",{"v":80,"d":"80.00"},197.88,"<1","N/A","http://selleckchem.com/products/lesinurad.html","C17H14BrN3O2S","free base","RDEA 594, RDEA-594, RDEA594","OC(=O)CSC1=NN=C(Br)[N]1C2=C3C=CC=CC3=C(C=C2)C4CC4",4.257,3,0,5]
["S4648","Dantrolene sodium hemiheptahydrate","f6","L6200-12","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.",399.29,"24868-20-0",{"v":14,"d":"14.00"},35.06,"<1","N/A","https://www.selleckchem.com/products/dantrolene-sodium-s4648.html","C14H9N4O5.7/2H2O.Na","Sodium salt hemiheptahydrate","Dantrolene sodium salt, Dantrium, Sodium dantrolene","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4651","Etoricoxib","g6","L6200-12","in 10mM DMSO","COX","Neuronal Signaling","Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.",358.84,"202409-33-4",{"v":71,"d":"71.00"},197.86,"<1","N/A","http://selleckchem.com/products/etoricoxib.html","C18H15ClN2O2S","free base","Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia","CC1=NC=C(C=C1)C2=NC=C(Cl)C=C2C3=CC=C(C=C3)[S](C)(=O)=O",3.467,4,0,3]
["S4656","Parecoxib","h6","L6200-12","in 10mM DMSO","COX","Neuronal Signaling","Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.",370.42,"198470-84-7",{"v":74,"d":"74.00"},199.77,"<1","N/A","http://selleckchem.com/products/parecoxib.html","C19H18N2O4S","free base","SC-69124, Valus-P, Vorth-P","CCC(=O)N[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",3.256,5,1,5]
["S4662","Atazanavir","a7","L6200-12","in 10mM DMSO","HIV Protease,P450 (e.g. CYP17),P-gp","Proteases","Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.",704.86,"198904-31-3",{"v":71,"d":"71.00"},100.73,"<1","N/A","http://selleckchem.com/products/atazanavir-reyataz.html","C38H52N6O7","free base","Latazanavir, Zrivada, Reyataz, BMS-232632","COC(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(O)CN(CC2=CC=C(C=C2)C3=NC=CC=C3)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C",{"v":4.69,"d":"4.690"},7,5,18]
["S4666","Sivelestat sodium tetrahydrate","b7","L6200-12","in 10mM DMSO","Serine Protease","Proteases","Sivelestat sodium tetrahydrate (ONO5046-Na, EI546, LY544349) is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.",528.51,"201677-61-4",{"v":100,"d":"100.00"},189.21,"<1","N/A","http://selleckchem.com/products/sivelestat-sodium.html","C20H21N2O7S.4H2O.Na","sodium salt","Sivelestat sodium, ONO5046-Na, Sodium sivelestat, EI546 sodium, LY544349 sodium","O.O.O.O.[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC([O-])=O",0.018,5,2,9]
["S4667","Lidocaine hydrochloride","c7","L6200-12","in 10mM DMSO","EGFR","Angiogenesis","Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.",{"v":270.8,"d":"270.80"},"73-78-9",{"v":54,"d":"54.00"},199.41,{"v":54,"d":"54.00"},199.41,"http://selleckchem.com/products/lidocaine-hydrochloride.html","C14H22N2O.HCl","hydrochloride","Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural","Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C",3.008,1,1,5]
["S4676","Gluconolactone","d7","L6200-12","in 10mM DMSO","Others","Others","Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.",178.14,"90-80-2",{"v":35,"d":"35.00"},196.47,{"v":35,"d":"35.00"},196.47,"http://www.selleckchem.com/products/gluconolactone.html","C6H10O6","Free Base","N/A","OCC1OC(=O)C(O)C(O)C1O",-2.229,2,4,1]
["S4682","Loxoprofen","e7","L6200-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.",{"v":246.3,"d":"246.30"},"68767-14-6",{"v":49,"d":"49.00"},198.94,"<1","N/A","http://selleckchem.com/products/loxoprofen.html","C15H18O3","free base","Koloxo, Loxoprofene, Loxoprofeno","CC(C(O)=O)C1=CC=C(CC2CCCC2=O)C=C1",2.936,2,0,4]
["S4685","Efavirenz","f7","L6200-12","in 10mM DMSO","Reverse Transcriptase","Microbiology","Efavirenz (Sustiva, Stocrin, DMP-266) is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.",315.67,"154598-52-4",{"v":63,"d":"63.00"},199.58,"<1","N/A","http://selleckchem.com/products/efavirenz.html","C14H9ClF3NO2","free base","Sustiva, Stocrin, DMP-266, DMP 266","FC(F)(F)C1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC3CC3",4.381,2,1,3]
["S4686","Vitamin E","g7","L6200-12","in 10mM DMSO","COX,VEGFR","Neuronal Signaling","Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.",430.71,"59-02-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/vitamin-e.html","C29H50O2","free base","Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S4697","Saxagliptin hydrate","h7","L6200-12","in 10mM DMSO","DPP","Proteases","Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.",333.43,"945667-22-1",{"v":66,"d":"66.00"},197.94,{"v":1,"d":"1.00"},{"v":3,"d":"3.00"},"http://selleckchem.com/products/saxagliptin-hydrate.html","C18H25N3O2.H2O","hydrate","BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate","O.NC(C(=O)N1C(CC2CC12)C#N)[C]34CC5[CH2]C(C[C](O)(C5)C3)C4",0.068,1,1,2]
["S4701","2-Deoxy-D-glucose (2-DG)","a8","L6200-12","in 10mM DMSO","Apoptosis related,Carbohydrate Metabolism,HSV","Metabolism","2-Deoxy-D-glucose (2-DG, 2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.",164.16,"154-17-6",{"v":32,"d":"32.00"},194.93,{"v":32,"d":"32.00"},194.93,"http://selleckchem.com/products/2-deoxy-d-glucose.html","C6H12O5","free base","2-deoxyglucose, NSC 15193, 2-Deoxy-D-arabino-hexose, D-Arabino-2-deoxyhexose","OCC1OC(O)CC(O)C1O",-1.748,1,3,1]
["S4706","Eugenol","b8","L6200-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eugenol (4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol) is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.",{"v":164.2,"d":"164.20"},"97-53-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/eugenol.html","C10H12O2","Free Base","4-Allyl-2-methoxyphenol, 4-Allylguaiacol, Eugenic acid, Allylguaiacol","COC1=C(O)C=CC(=C1)CC=C",2.579,1,1,3]
["S4709","Latanoprost","c8","L6200-12","in 10mM DMSO","GPR,Immunology & Inflammation related,RAR/RXR","Immunology & Inflammation","Latanoprost (Xalatan, PhXA41) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.",432.59,"130209-82-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/latanoprost.html","C26H40O5","Free Base","Xalatan, PhXA41, PHXA-41","CC(C)OC(=O)CCC\\C=C/CC1C(O)CC(O)C1CCC(O)CCC2=CC=CC=C2",4.365,2,3,14]
["S4710","Picolinamide","d8","L6200-12","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.",122.12,"1452-77-3",{"v":24,"d":"24.00"},196.53,{"v":24,"d":"24.00"},196.53,"http://selleckchem.com/products/picolinamide.html","C6H6N2O","free base","2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine","NC(=O)C1=NC=CC=C1",{"v":0.11,"d":"0.110"},2,1,1]
["S4711","Esculetin","e8","L6200-12","in 10mM DMSO","Lipoxygenase","Metabolism","Esculetin (Cichorigenin, Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).",178.14,"305-01-1",{"v":35,"d":"35.00"},196.47,"<1","N/A","http://selleckchem.com/products/esculetin.html","C9H6O4","free base","Cichorigenin, Aesculetin","OC1=CC2=C(C=CC(=O)O2)C=C1O",1.415,2,2,0]
["S4712","Diethylmaleate","f8","L6200-12","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Diethylmaleate (Diethyl ester, Maleic acid diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.",172.18,"141-05-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/diethylmaleate.html","C8H12O4","Free Base","Diethyl ester, Maleic acid diethyl ester","CCOC(=O)\\C=C/C(=O)OCC",1.187,4,0,6]
["S4715","Benzamide","g8","L6200-12","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Benzamide, a derivative of benzoic acid, is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.",121.14,"55-21-0",{"v":24,"d":"24.00"},198.12,"<1","N/A","http://selleckchem.com/products/benzamide.html","C7H7NO","free base","N/A","NC(=O)C1=CC=CC=C1",0.832,1,1,1]
["S4722","(+)-Catechin","h8","L6200-12","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,",290.27,"154-23-4",{"v":58,"d":"58.00"},199.81,{"v":58,"d":"58.00"},199.81,"http://selleckchem.com/products/catechin.html","C15H14O6","free base","Cianidanol, Catechinic acid, Catechuic acid, Catechin","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4723","(-)Epicatechin","a9","L6200-12","in 10mM DMSO","Antioxidant","Immunology & Inflammation","(−)Epicatechin (L-Epicatechin, (-)-Epicatechol) is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has insulin mimic action and improves heart health.",290.27,"490-46-0",{"v":58,"d":"58.00"},199.81,"<1","N/A","http://selleckchem.com/products/-epicatechin.html","C15H14O6","free base","L-Epicatechin, (-)-Epicatechol","OC1CC2=C(OC1C3=CC(=C(O)C=C3)O)C=C(O)C=C2O",2.021,1,5,1]
["S4725","Benzenesulfonamide","b9","L6200-12","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.",157.19,"98-10-2",{"v":31,"d":"31.00"},197.21,"<1","N/A","http://selleckchem.com/products/benzenesulfonamide.html","C6H7NO2S","free base","Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide","N[S](=O)(=O)C1=CC=CC=C1",0.535,2,1,1]
["S4731","Perphenazine","c9","L6200-12","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Perphenazine (Perphenazin, Trilafon, Etaperazine) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.",403.97,"58-39-9",{"v":74,"d":"74.00"},183.18,"<1","N/A","http://selleckchem.com/products/perphenazine.html","C21H26ClN3OS","free base","Perphenazin, Trilafon, Etaperazine","OCCN1CCN(CCCN2C3=CC=CC=C3SC4=C2C=C(Cl)C=C4)CC1",4.157,0,1,6]
["S4732","MPTP hydrochloride","d9","L6200-12","in 10mM DMSO","Apoptosis related,Dopamine Receptor","Neuronal Signaling","MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.",209.72,"23007-85-4",{"v":20,"d":"20.00"},95.37,{"v":41,"d":"41.00"},{"v":195.5,"d":"195.50"},"http://selleckchem.com/products/mptp-hydrochloride.html","C12H15N.HCl","hydrochloride","N/A","Cl.CN1CCC(=CC1)C2=CC=CC=C2",2.788,0,0,1]
["S4735","Salvianolic acid B","e9","L6200-12","in 10mM DMSO","Sirtuin","Epigenetics","Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.",718.61,"121521-90-2",{"v":100,"d":"100.00"},139.16,{"v":100,"d":"100.00"},139.16,"http://selleckchem.com/products/salvianolic-acid-b.html","C36H30O16","free base","Sal B, Lithospermate B, Lithospermic acid B","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=CC=C(O)C3=C2C(C(O3)C4=CC=C(O)C(=C4)O)C(=O)OC(CC5=CC=C(O)C(=C5)O)C(O)=O",4.718,7,7,14]
["S4737","Psoralen","f9","L6200-12","in 10mM DMSO","ADC Cytotoxin,DNA/RNA Synthesis","DNA Damage/DNA Repair","Psoralen (Psoralene, Ficusin, Furocoumarin) is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.",186.16,"66-97-7",{"v":37,"d":"37.00"},198.75,"<1","N/A","http://selleckchem.com/products/psoralen.html","C11H6O3","free base","Psoralene, Ficusin, Furocoumarin","O=C1OC2=C(C=C1)C=C3C=COC3=C2",2.203,3,0,0]
["S4739","Oxyresveratrol","g9","L6200-12","in 10mM DMSO","Tyrosinase","Proteases","Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.",244.24,"29700-22-9",{"v":48,"d":"48.00"},196.53,{"v":1,"d":"1.00"},4.09,"http://selleckchem.com/products/oxyresveratrol.html","C14H12O4","free base","Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene","OC1=CC=C(\\C=C\\C2=CC(=CC(=C2)O)O)C(=C1)O",2.848,0,4,2]
["S4743","Wogonin","h9","L6200-12","in 10mM DMSO","CDK,Transferase","Cell Cycle","Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.",284.26,"632-85-9",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"<1","N/A","http://selleckchem.com/products/wogonin.html","C16H12O5","free base","Vogonin","COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C3=CC=CC=C3",2.636,3,2,2]
["S4746","(20S)-Protopanaxadiol","a10","L6200-12","in 10mM DMSO","P-gp","Transmembrane Transporters","20(S)-Protopanaxadiol (PPD, 20-Epiprotopanaxadiol), the main intestinal metabolite of ginsenosides, is one of the active ingredients in ginseng. 20(S)-Protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.",460.73,"30636-90-9",{"v":92,"d":"92.00"},199.68,"<1","N/A","http://selleckchem.com/products/20s-protopanaxadiol.html","C30H52O3","free base","20-Epiprotopanaxadiol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4CCC23C",5.789,0,2,4]
["S4747","Jervine","b10","L6200-12","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Jervine (11-Ketocyclopamine) is a Hedgehog signaling (IC50=500-700 nM) inhibitor that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.",{"v":425.6,"d":"425.60"},"469-59-0",{"v":5,"d":"5.00"},11.75,"<1","N/A","http://selleckchem.com/products/jervine.html","C27H39NO3","free base","11-Ketocyclopamine","CC1CNC2C(C)C3(CCC4C5CC=C6CC(O)CCC6(C)C5C(=O)C4=C3C)OC2C1",3.472,2,2,0]
["S4749","Citalopram HBr","c10","L6200-12","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.",{"v":405.3,"d":"405.30"},"59729-32-7",{"v":81,"d":"81.00"},199.85,{"v":81,"d":"81.00"},199.85,"http://selleckchem.com/products/citalopram-hbr.html","C20H21FN2O.HBr","hydrobromide","Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr","Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C3=CC=C(F)C=C3",4.212,1,0,5]
["S4750","Sulfacetamide sodium salt hydrate","d10","L6200-12","in 10mM DMSO","Antibiotics,Autophagy,Bacterial","Autophagy","Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.",254.24,"6209-17-2",{"v":50,"d":"50.00"},196.66,{"v":50,"d":"50.00"},196.66,"http://selleckchem.com/products/sulfacetamide-sodium-salt-hydrate.html","C8H9N2O3S.H2O.Na","sodium salt hyd","N/A","O.CC(=O)N([Na])[S](=O)(=O)C1=CC=C(N)C=C1",-0.326,3,1,2]
["S4753","Ganoderic acid A","e10","L6200-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.",516.67,"81907-62-2",{"v":100,"d":"100.00"},193.55,"<1","N/A","http://selleckchem.com/products/ganoderic-acid-a.html","C30H44O7","free base","N/A","CC(CC(=O)CC(C)C(O)=O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C4(C)CCC(=O)C(C)(C)C4CC3O",2.775,4,2,6]
["S4759","p-Coumaric Acid","f10","L6200-12","in 10mM DMSO","Anti-infection","Microbiology","p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.",164.16,"501-98-4",{"v":32,"d":"32.00"},194.93,"<1","N/A","http://selleckchem.com/products/p-coumaric-acid.html","C9H8O3","free base","4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid","OC(=O)\\C=C\\C1=CC=C(O)C=C1",1.685,1,1,2]
["S4761","Thymoquinone","g10","L6200-12","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymoquinone (TQ) is the bioactive phytochemical constituent of the seeds oil of Nigella sativa with anti-inflammatory and anti-oxidant effects.",{"v":164.2,"d":"164.20"},"490-91-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/thymoquinone.html","C10H12O2","free base","N/A","CC(C)C1=CC(=O)C(=CC1=O)C",2.288,2,0,1]
["S4763","4-Hydroxychalcone","h10","L6200-12","in 10mM DMSO","NF-κB","NF-κB","4-Hydroxychalcone (P-Cinnamoylphenol) is a chalcone metabolite with diverse biological activities. It inhibits TNFα-induced NF-κB pathway activation in a dose-dependent manner and also activates BMP signaling.",224.25,"20426-12-4",{"v":44,"d":"44.00"},196.21,"N/A","N/A","http://selleckchem.com/products/4-hydroxychalcone.html","C15H12O2","free base","P-Cinnamoylphenol","OC1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2",{"v":3.46,"d":"3.460"},1,1,3]
["S4765","Syringaldehyde","a11","L6200-12","in 10mM DMSO","COX","Immunology & Inflammation","Syringaldehyde (Syringic aldehyde) is an organic compound that occurs naturally in trace amounts. It possesses worthy bioactive properties and is, therefore, used in pharmaceuticals, food, cosmetics, textiles, pulp and paper industries, and even in biological control applications.  Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities.",182.17,"134-96-3",{"v":36,"d":"36.00"},197.62,"N/A","N/A","http://selleckchem.com/products/syringaldehyde.html","C9H10O4","free base","Syringic aldehyde","COC1=C(O)C(=CC(=C1)C=O)OC",1.314,3,1,3]
["S4766","Gibberellic acid","b11","L6200-12","in 10mM DMSO","Others","Others","Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.",346.37,"77-06-5",{"v":69,"d":"69.00"},199.21,"N/A","N/A","http://selleckchem.com/products/gibberellic-acid.html","C19H22O6","free base","Gibberellin, Gibberellin A3, GA3","CC12C(O)C=CC3(OC1=O)C4CCC5(O)CC4(CC5=C)C(C23)C(O)=O",0.442,3,1,1]
["S4771","β-thujaplicin","c11","L6200-12","in 10mM DMSO","DNA Methyltransferase","Epigenetics","β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods.  Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.",{"v":164.2,"d":"164.20"},"499-44-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/beta-thujaplicin.html","C10H12O2","free base","Hinokitiol, 4-Isopropyltropolone","CC(C)C1=CC=CC(=O)C(=C1)O",1.896,1,1,1]
["S4779","Menadiol Diacetate","d11","L6200-12","in 10mM DMSO","Vitamin","Microbiology","Menadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation.",258.27,"573-20-6",{"v":51,"d":"51.00"},197.47,"N/A","N/A","http://selleckchem.com/products/menadiol-diacetate.html","C15H14O4","free base","Vitamin K4, Acetomenaphthone, Kapilin","CC(=O)OC1=C2C=CC=CC2=C(OC(C)=O)C(=C1)C",2.759,4,0,4]
["S4782","5-methoxyflavone","e11","L6200-12","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.",252.26,"42079-78-7",{"v":50,"d":"50.00"},198.21,"N/A","N/A","http://selleckchem.com/products/5-methoxyflavone.html","C16H12O3","free base","N/A","COC1=CC=CC2=C1C(=O)C=C(O2)C3=CC=CC=C3",{"v":0,"d":"0.000"},0,0,0]
["S4783","Benzyl isothiocyanate","f11","L6200-12","in 10mM DMSO","Antibiotics","Microbiology","Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.",149.21,"622-78-6",{"v":29,"d":"29.00"},194.36,"N/A","N/A","http://selleckchem.com/products/benzyl-isothiocyanate.html","C8H7NS","free base","Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester","S=C=NCC1=CC=CC=C1",{"v":0,"d":"0.000"},0,0,0]
["S4784","Phloracetophenone","g11","L6200-12","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Phloracetophenone, or 2,4,6-trihydroxyacetophenone (THA), the aglycone component of phloracetophenone glucoside, is a naturally occurring compound obtained from the rhizome of Curcuma comosa (Family Zingiberaceae). Phloracetophenone can stimulate CYP7A1 activity. Phloracetophenone induces cholestasis in rats mediated through Mrp2.",168.15,"480-66-0",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/phloracetophenone.html","C8H8O4","free base","2,4,6-trihydroxyacetophenone","CC(=O)C1=C(O)C=C(O)C=C1O",{"v":0,"d":"0.000"},0,0,0]
["S4803","Thymidine (NSC 21548)","h11","L6200-12","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Thymidine (Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd, NSC 21548) is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix.",242.23,"50-89-5",{"v":48,"d":"48.00"},198.16,"N/A","N/A","http://selleckchem.com/products/thymidine.html","C10H14N2O5","free base","Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd","CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O",{"v":0,"d":"0.000"},0,0,0]
["S4809","3-Indolepropionic acid","a2","L6200-13","in 10mM DMSO","Others","Others","3-Indolepropionic acid (IPA, indole-3-propionic acid), a gut microbial metabolite, is a potent neuroprotective antioxidant and plant auxin.",189.21,"830-96-6",{"v":37,"d":"37.00"},195.55,"N/A","N/A","http://selleckchem.com/products/3-indolepropionic-acid.html","C11H11NO2","free base","indole-3-propionic acid, Indolepropionic acid","OC(=O)CCC1=C[NH]C2=C1C=CC=C2",{"v":0,"d":"0.000"},0,0,0]
["S4831","Piperonyl butoxide","b2","L6200-13","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Piperonyl butoxide (PBO, Butacide, Ethanol butoxide, Pyrenone 606,ENT-14250) is a man-made pesticide synergist, working with insect killers to increase their effectiveness.Piperonyl butoxide is an inhibitor of cytochrome P450 monooxygenases(P450s).",338.44,"51-03-6",{"v":67,"d":"67.00"},197.97,"N/A","N/A","http://selleckchem.com/products/piperonyl-butoxide.html","C19H30O5","Peroxides","Butacide, Ethanol butoxide, Pyrenone 606,ENT-14250","CCCCOCCOCCOCC1=CC2=C(OCO2)C=C1CCC",3.867,5,0,13]
["S4832","Tolmetin","c2","L6200-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.",257.28,"26171-23-3",{"v":51,"d":"51.00"},198.23,"N/A","N/A","http://selleckchem.com/products/tolmetin.html","C15H15NO3","free base","Tolectin","C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(O)=O",3.267,2,0,4]
["S4835","Aceclofenac","d2","L6200-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.",354.18,"89796-99-6",{"v":70,"d":"70.00"},197.64,"N/A","N/A","http://selleckchem.com/products/aceclofenac.html","C16H13Cl2NO4","free base","Preservex, Airtal","OC(=O)COC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",{"v":4.08,"d":"4.080"},3,1,7]
["S4849","Levocetirizine Dihydrochloride","e2","L6200-13","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.",461.81,"130018-87-0",{"v":92,"d":"92.00"},199.22,{"v":92,"d":"92.00"},199.22,"http://selleckchem.com/products/levocetirizine-dihydrochloride.html","C21H25ClN2O3.2HCl","dihydrochloride","Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride","Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3",1.217,2,0,8]
["S4853","Ecabet sodium","f2","L6200-13","in 10mM DMSO","ROS","Apoptosis","Ecabet sodium (TA-2711, TA-2711E) is a widely employed mucoprotective agent for the treatment of gastric ulcers. Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8, Ecabet sodium can also reduce apoptosis.",402.48,"86408-72-2",{"v":80,"d":"80.00"},198.77,{"v":16,"d":"16.00"},39.75,"http://selleckchem.com/products/ecabet-sodium.html","C20H27O5S.Na","sodium salt","TA-2711, TA-2711E","[Na+].CC(C)C1=CC2=C(C=C1[S]([O-])(=O)=O)C3(C)CCCC(C)(C3CC2)C(O)=O",2.477,1,0,3]
["S4856","Iproniazid","g2","L6200-13","in 10mM DMSO","MAO","Metabolism","Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.",179.22,"54-92-2",{"v":35,"d":"35.00"},195.29,{"v":35,"d":"35.00"},195.29,"http://selleckchem.com/products/Iproniazid.html","C9H13N3O","free base","Marsilid, Iprazid","CC(C)NNC(=O)C1=CC=NC=C1",0.121,2,2,3]
["S4862","Squalene","h2","L6200-13","in 10mM DMSO","Fungal","Microbiology","Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.",410.72,"111-02-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/squalene.html","C30H50","free base","Spinacene, Supraene, trans-Squalene","CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(C)\\CC\\C=C(C)\\CCC=C(C)C",11.331,0,0,15]
["S4866","Nicarbazin","a3","L6200-13","in 10mM DMSO","Parasite","Microbiology","Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug.",426.38,"330-95-0",{"v":9,"d":"9.00"},21.11,"<1","N/A","http://selleckchem.com/products/nicarbazin.html","C13H10N4O5.C6H8N2O","salt","N/A","CC1=NC(=NC(=C1)C)O.[O-][N+](=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)[N+]([O-])=O)C=C2",3.207,3,3,4]
["S4900","Tenovin-6","b3","L6200-13","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.",454.63,"1011557-82-6",{"v":98,"d":"98.00"},215.56,{"v":98,"d":"98.00"},215.56,"http://selleckchem.com/products/tenovin-6.html","C25H34N4O2S","free base","N/A","Cl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",{"v":5.7,"d":"5.700"},2,3,11]
["S4902","QNZ (EVP4593)","c3","L6200-13","in 10mM DMSO","NF-κB,TNF-alpha","NF-κB","QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.",356.42,"545380-34-5",{"v":5,"d":"5.00"},14.03,"<1","N/A","http://selleckchem.com/products/qnz-evp4593.html","C22H20N4O","free base","N/A","NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1",4.454,3,2,6]
["S4904","JZL184","d3","L6200-13","in 10mM DMSO","Lipase","Metabolism","JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.",520.49,"1101854-58-3",{"v":100,"d":"100.00"},192.13,"<1","N/A","http://selleckchem.com/products/jzl184.html","C27H24N2O9","free base","N/A","OC(C1CCN(CC1)C(=O)OC2=CC=C(C=C2)[N+]([O-])=O)(C3=CC=C4OCOC4=C3)C5=CC=C6OCOC6=C5",4.292,6,0,6]
["S4907","SC-514","e3","L6200-13","in 10mM DMSO","IκB/IKK","NF-κB","SC-514 (GK 01140) is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.",{"v":224.3,"d":"224.30"},"354812-17-2",{"v":45,"d":"45.00"},200.62,"<1","N/A","http://selleckchem.com/products/sc-514.html","C9H8N2OS2","free base","GK 01140","NC(=O)C1=C(N)C=C(S1)C2=CSC=C2",{"v":1.51,"d":"1.510"},1,2,2]
["S4908","SN-38","f3","L6200-13","in 10mM DMSO","ADC Cytotoxin,Autophagy,Topoisomerase","DNA Damage/DNA Repair","SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy.",{"v":392.4,"d":"392.40"},"86639-52-3",{"v":21,"d":"21.00"},53.52,"<1","N/A","http://selleckchem.com/products/sn-38.html","C22H20N2O5","free base","NK012","CCC1=C2CN3C(=O)C4=C(C=C3C2=NC5=C1C=C(O)C=C5)C(O)(CC)C(=O)OC4",2.446,4,1,2]
["S4920","b-AP15","g3","L6200-13","in 10mM DMSO","DUB","Ubiquitin","b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.",419.39,"1009817-63-3",{"v":48,"d":"48.00"},114.45,"<1","N/A","http://selleckchem.com/products/b-ap15.html","C22H17N3O6","free base","NSC687852","[O-][N+](=O)C1=CC=C(C=C1)\\C=C2/CN(C\\C(=C/C3=CC=C(C=C3)[N+]([O-])=O)C2=O)C(=O)C=C",3.653,2,0,5]
["S4921","MNS (3,4-Methylenedioxy-β-nitrostyrene)","h3","L6200-13","in 10mM DMSO","p97,Src,Syk,Tyrosinase","Ubiquitin","MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.",193.16,"1485-00-3",{"v":39,"d":"39.00"},201.91,"<1","N/A","http://selleckchem.com/products/mdbn.html","C9H7NO4","free base","MDBN","[O-][N+](=O)/C=C/C1=CC2=C(OCO2)C=C1",1.578,2,0,2]
["S4935","Asunaprevir (BMS-650032)","a4","L6200-13","in 10mM DMSO","HCV Protease","Proteases","Asunaprevir (BMS-650032) is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.",748.29,"630420-16-5",{"v":100,"d":"100.00"},133.64,"<1","N/A","http://selleckchem.com/products/asunaprevir.html","C35H46ClN5O9S","free base","BMS-650032","COC1=C2C=CC(=CC2=C(OC3CC(N(C3)C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)NC4(CC4C=C)C(=O)N[S](=O)(=O)C5CC5)N=C1)Cl",3.565,10,3,14]
["S4937","4'-Hydroxychalcone","b4","L6200-13","in 10mM DMSO","NF-κB","NF-κB","4'-Hydroxychalcone (P-Cinnamoylphenol), found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones. It has diverse biological activities, inhibiting TNFα-induced NF-κB pathway activation in a dose-dependent manner and activating BMP signaling.",224.25,"2657-25-2",{"v":44,"d":"44.00"},196.21,"N/A","N/A","http://selleckchem.com/products/hydroxychalcone.html","C15H12O2","free base","P-Cinnamoylphenol","OC1=CC=C(C=C1)C(=O)\\C=C\\C2=CC=CC=C2",{"v":3.46,"d":"3.460"},1,1,3]
["S4938","Cedrol","c4","L6200-13","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Cedrol, a natural occuring sesquiterpene alcohol, is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.",222.37,"77-53-2",{"v":44,"d":"44.00"},197.87,"N/A","N/A","http://selleckchem.com/products/cedrol.html","C15H26O","free base","N/A","CC1CCC2C(C)(C)C3CC12CCC3(C)O",3.157,0,0,0]
["S4940","Maltol","d4","L6200-13","in 10mM DMSO","Antioxidant","PI3K/Akt/mTOR","Maltol (Larixinic acid, Palatone, Veltol) is a naturally occurring organic compound that is flavour enhancer and flavouring agent.",126.11,"118-71-8",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/maltol.html","C6H6O3","Pyrone","Larixinic acid, Palatone, Veltol","CC1=C(O)C(=O)C=CO1",-0.222,2,1,0]
["S4941","Farnesol","e4","L6200-13","in 10mM DMSO","Antibiotics","Microbiology","Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.",222.37,"4602-84-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/farnesol.html","C15H26O","free base","N/A","CC(C)=CCCC(/C)=C/CCC(/C)=C/CO",{"v":4.76,"d":"4.760"},0,1,7]
["S4943","Isovanillin","f4","L6200-13","in 10mM DMSO","Others","Immunology & Inflammation","Isovanillin (5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehyde) is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical.",152.15,"621-59-0",{"v":30,"d":"30.00"},197.17,"N/A","N/A","http://selleckchem.com/products/lsovanillin.html","C8H8O3","free base","5-Formylguaiacol, 3-Hydroxy-p-anisaldehyde, 3-Hydroxy-4-methoxybenzaldehyde","COC1=C(O)C=C(C=O)C=C1",{"v":1.33,"d":"1.330"},2,1,2]
["S4957","Linalool","g4","L6200-13","in 10mM DMSO","NMDAR","Neuronal Signaling","Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.",154.25,"78-70-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/linalool.html","C10H18O","free base","Phantol","CC(C)=CCCC(C)(O)C=C",2.735,0,0,4]
["S4964","Lactobionic acid","h4","L6200-13","in 10mM DMSO","MMP","Proteases","Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. Lactobionic acid inhibits matrix-metalloproteinase (MMP) activity.",{"v":358.3,"d":"358.30"},"96-82-2",{"v":71,"d":"71.00"},198.16,"N/A","N/A","http://selleckchem.com/products/lactobionic-acid.html","C12H22O12","Disaccharides","Galactosylgluconic acid","OCC(O)C(OC1OC(CO)C(O)C(O)C1O)C(O)C(O)C(O)=O",{"v":-4.56,"d":"-4.560"},3,8,8]
["S4966","4-Methylesculetin","a5","L6200-13","in 10mM DMSO","Immunology & Inflammation related,Interleukins,Peroxidases","Metabolism","4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.",192.17,"529-84-0",{"v":38,"d":"38.00"},197.74,"N/A","N/A","http://selleckchem.com/products/methylesculetin.html","C10H8O4","free base","N/A","CC1=CC(=O)OC2=C1C=C(O)C(=C2)O",1.862,2,2,0]
["S4970","Nerol","b5","L6200-13","in 10mM DMSO","Fungal,ROS","Apoptosis","Nerol (Cis-Geraniol, Neryl alcohol) is a monoterpene found in many essential oils such as lemongrass and hops. Nerol has antifungal activity, Nerol can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis.",154.25,"106-25-2","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/nerol.html","C10H18O","free base","Cis-Geraniol, Neryl alcohol","CC(C)=CCC\\C(C)=C/CO",2.934,0,1,4]
["S4977","Efonidipine","c5","L6200-13","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.",631.66,"111011-63-3",{"v":100,"d":"100.00"},158.31,"N/A","N/A","http://selleckchem.com/products/efonidipine.html","C34H38N3O7P","free base","NZ-105","CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",4.956,4,1,11]
["S4981","Cyclogalegenol","d5","L6200-13","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.",490.71,"78574-94-4",{"v":98,"d":"98.00"},199.71,"<1","N/A","http://selleckchem.com/products/cyclogalegenol.html","C30H50O5","Cyclohexanol","Astramembrangenin, Cyclosieversigenin","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(O)CCC56CC46CCC23C",2.635,1,3,2]
["S4990","TBHQ","e5","L6200-13","in 10mM DMSO","Nrf2","Immunology & Inflammation","Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.",166.22,"1948-33-0",{"v":33,"d":"33.00"},198.53,"N/A","N/A","http://selleckchem.com/products/tbhq.html","C10H14O2","free base","Tert-butylhydroquinone","CC(C)(C)C1=C(O)C=CC(=C1)O",2.746,0,2,1]
["S4997","4-Butylresorcinol","f5","L6200-13","in 10mM DMSO","Tyrosinase","Proteases","4-Butylresorcinol (4-n-Butylresorcinol, Rucinol) is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.",166.22,"18979-61-8",{"v":34,"d":"34.00"},204.55,{"v":-1,"d":"-1.00"},-6.02,"https://www.selleckchem.com/products/4-butylresorcinol.html","C10H14O2","Resorcinol","4-n-Butylresorcinol, Rucinol","CCCCC1=CC=C(O)C=C1O",{"v":3.2,"d":"3.200"},0,2,3]
["S4999","Avermectin B1","g5","L6200-13","in 10mM DMSO","Parasite","Microbiology","Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.",873.08,"71751-41-2",{"v":100,"d":"100.00"},114.54,"N/A","N/A","http://selleckchem.com/products/avermectin.html","C48H72O14","Macrocyclic lactones","abamectin","CCC(C)C1OC2(CC3CC(C\\C=C(C)\\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\\C=C\\C=C\\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2)C=CC1C",4.692,11,2,8]
["S5001","Tofacitinib (CP-690550) Citrate","h5","L6200-13","in 10mM DMSO","Anti-infection,JAK","JAK/STAT","Tofacitinib citrate (CP-690550, Tasocitinib) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively. Tofacitinib citrate has anti-infection activity.",504.49,"540737-29-9",{"v":100,"d":"100.00"},198.22,"<1","N/A","http://selleckchem.com/products/CP-690550.html","C16H20N6O.C6H8O7","Citrate","Tasocitinib Citrate,CP-690550","CC1CCN(CC1N(C)C2=C3C=C[NH]C3=NC=N2)C(=O)CC#N.OC(=O)CC(O)(CC(O)=O)C(O)=O",0.193,6,1,8]
["S5002","Fingolimod (FTY720) HCl","a6","L6200-13","in 10mM DMSO","S1P Receptor","GPCR & G Protein","Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.",{"v":343.9,"d":"343.90"},"162359-56-0",{"v":69,"d":"69.00"},200.64,{"v":69,"d":"69.00"},200.64,"http://selleckchem.com/products/FTY720.html","C19H33NO2.HCl","Hydrochloride","Fingolimod Hydrochloride,FTY720","Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",{"v":4.58,"d":"4.580"},0,3,12]
["S5003","Tacrolimus (FK506)","b6","L6200-13","in 10mM DMSO","Autophagy,FKBP,phosphatase","PI3K/Akt/mTOR","Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.",804.02,"104987-11-3",{"v":94,"d":"94.00"},116.91,"<1","N/A","http://selleckchem.com/products/FK-506-(Tacrolimus).html","C44H69NO12","free base","FK506, FR900506, Fujimycin, Prograf","COC1CC(CCC1O)\\C=C(C)\\C2OC(=O)C3CCCCN3C(=O)C(=O)C4(O)OC(C(CC(C)C/C(=C/C(CC=C)C(=O)CC(O)C2C)C)OC)C(CC4C)OC",4.832,9,2,7]
["S5006","Teprenone","c6","L6200-13","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Teprenone, an acylic polyisoprenoid, that is known as tetraprenylacetone or geranylgeranylacetone, is an anti-ulcer drug, clinically used for gastritis.  Teprenone(Geranylgeranylacetone) is an inducer of heat shock proteins (HSPs) expression.",330.55,"6809-52-5",{"v":66,"d":"66.00"},199.67,"N/A","N/A","http://selleckchem.com/products/teprenone.html","C23H38O","Isoprenoids","Geranylgeranylacetone, Tetraprenylacetone","CC(C)=CCC/C(C)=C/CC\\C(C)=C\\CC\\C(C)=C\\CCC(C)=O",7.413,1,0,12]
["S5010","Indometacin Sodium","d6","L6200-13","in 10mM DMSO","COX","Immunology & Inflammation","Indometacin Sodium (Indomethacin Sodium) is the sodium salt of indomethacin, which is a non-selective, reversible, and competitive inhibitor of cyclooxygenases 1 and 2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects.",433.82,"74252-25-8",{"v":87,"d":"87.00"},200.55,{"v":-1,"d":"-1.00"},-2.31,"https://www.selleckchem.com/products/indometacin-sodium.html","C19H21ClNNaO7","sodium salt trihydrate","Indomethacin Sodium","O.O.O.COC1=CC2=C(C=C1)[N](C(=C2CC(=O)O[Na])C)C(=O)C3=CC=C(Cl)C=C3",3.705,4,0,5]
["S5015","Simeprevir (TMC435)","e6","L6200-13","in 10mM DMSO","HCV Protease","Proteases","Simeprevir (TMC-435, TMC-435350) is a competitive, reversible, macrocyclic, noncovalent hepatitis C virus (HCV) NS3/4A protease inhibitor that acts directly against the hepatitis C virus. It has a medium inhibitory concentration (IC50) <13 nM for all HCV NS3/4A enzymes(genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3.",749.94,"923604-59-5",{"v":100,"d":"100.00"},133.34,"<1","N/A","http://selleckchem.com/products/simeprevir.html","C38H47N5O7S2","free base","TMC-435350","COC1=C(C)C2=NC(=CC(=C2C=C1)OC3CC4C(C3)C(=O)N(C)CCCC\\C=C/C5CC5(NC4=O)C(=O)N[S](=O)(=O)C6CC6)C7=NC(=CS7)C(C)C",4.796,9,2,8]
["S5017","Oxyclozanide","f6","L6200-13","in 10mM DMSO","Parasite","Microbiology","Oxyclozanide (Oxiclozanidum, Zanil, Oxyclozanid, Zanilox) is a salicylanilide anthelmintic and mitochondrial uncoupling anthelmintic drug approved for veterinary use.",401.46,"2277-92-1",{"v":80,"d":"80.00"},199.27,"N/A","N/A","http://selleckchem.com/products/oxyclozanide.html","C13H6Cl5NO3","free base","Oxiclozanidum, Zanil, Oxyclozanid, Zanilox","OC1=C(Cl)C=C(Cl)C=C1NC(=O)C2=C(O)C(=CC(=C2Cl)Cl)Cl",5.452,1,3,2]
["S5019","Indobufen","g6","L6200-13","in 10mM DMSO","COX","Immunology & Inflammation","Indobufen (Ibustrin, K 3920) is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.",295.33,"63610-08-2",{"v":59,"d":"59.00"},199.78,"N/A","N/A","http://selleckchem.com/products/indobufen.html","C18H17NO3","free base","Ibustrin, K 3920","CCC(C(O)=O)C1=CC=C(C=C1)N2CC3=C(C=CC=C3)C2=O",3.157,2,0,4]
["S5058","Revaprazan Hydrochloride","h6","L6200-13","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.",{"v":398.9,"d":"398.90"},"178307-42-1",{"v":16,"d":"16.00"},40.11,"N/A","N/A","http://selleckchem.com/products/revaprazan-hydrochloride.html","C22H23FN4.HCl","HCl","YH1885","Cl.CC1N(CCC2=C1C=CC=C2)C3=NC(=NC(=C3C)C)NC4=CC=C(F)C=C4",6.215,2,1,3]
["S5059","Pixantrone Maleate","a7","L6200-13","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Pixantrone (BBR-2778) is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites.",557.51,"144675-97-8",{"v":100,"d":"100.00"},179.37,{"v":100,"d":"100.00"},179.37,"http://selleckchem.com/products/pixantrone-maleate.html","C17H19N5O2.2C4H4O4","dimaleate","BBR-2778","NCCNC1=CC=C(NCCN)C2=C1C(=O)C3=C(C=NC=C3)C2=O.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",-5.263,7,4,10]
["S5060","Metadoxine","b7","L6200-13","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.  Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.",298.29,"74536-44-0",{"v":59,"d":"59.00"},197.79,"N/A","N/A","http://selleckchem.com/products/metadoxine.html","C8H11NO3.C5H7NO3","salt","Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat","CC1=C(O)C(=C(CO)C=N1)CO.OC(=O)C2CCC(=O)N2",-1.243,3,4,3]
["S5062","Daclatasvir Dihydrochloride","c7","L6200-13","in 10mM DMSO","HCV Protease","Microbiology","Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection.",{"v":811.8,"d":"811.80"},"1009119-65-6",{"v":100,"d":"100.00"},123.18,{"v":100,"d":"100.00"},123.18,"https://www.selleckchem.com/products/daclatasvir-dihydrochloride.html","C40H50N8O6.2HCl","dihydrochloride","N/A","Cl.Cl.COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C([NH]5)C6CCCN6C(=O)C(NC(=O)OC)C(C)C",5.812,8,4,13]
["S5063","Trelagliptin succinate","d7","L6200-13","in 10mM DMSO","DPP","Proteases","Trelagliptin succinate (SYR472) is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).",475.47,"1029877-94-8",{"v":95,"d":"95.00"},{"v":199.8,"d":"199.80"},{"v":95,"d":"95.00"},{"v":199.8,"d":"199.80"},"http://selleckchem.com/products/trelagliptin-succinate.html","C18H20FN5O2.C4H6O4","succinate","SYR472","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC(=CC=C3C#N)F)C1=O.OC(=O)CCC(O)=O",-1.362,4,1,6]
["S5065","Ganciclovir sodium","e7","L6200-13","in 10mM DMSO","CMV","Microbiology","Ganciclovir Sodium (RS-21592, Cytovene IV, BW 759, 2'-Nor-2'-deoxyguanosine) is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV).",277.21,"107910-75-8",{"v":55,"d":"55.00"},198.41,{"v":55,"d":"55.00"},198.41,"https://www.selleckchem.com/products/ganciclovir-sodium.html","C9H12N5NaO4","Nucleoside","RS-21592 sodium, Cytovene IV sodium, BW 759 sodium, 2'-Nor-2'-deoxyguanosine sodium","[Na+].NC1=NC2=C(N=C[N]2COC(CO)CO)C(=N1)[O-]",-1.859,4,3,5]
["S5073","Donepezil","f7","L6200-13","in 10mM DMSO","AChR","Neuronal Signaling","Donepezil (Aricept, Donepezilo) is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer's type.",379.49,"120014-06-4",{"v":75,"d":"75.00"},197.63,"N/A","N/A","http://selleckchem.com/products/donepezil.html","C24H29NO3","free base","Aricept, Donepezilo","COC1=CC2=C(C=C1OC)C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)C2",4.569,3,0,6]
["S5077","Regorafenib (BAY-734506) Monohydrate","g7","L6200-13","in 10mM DMSO","c-Kit,c-RET,PDGFR,Raf,VEGFR","Protein Tyrosine Kinase","Regorafenib (BAY-734506, Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate) Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, Kit (c-Kit), RET (c-RET), RAF-1, B-RAF and B-RAF(V600E) respectively.",500.83,"1019206-88-2",{"v":100,"d":"100.00"},199.67,"N/A","N/A","http://selleckchem.com/products/regorafenib-monohydrate.html","C21H15ClF4N4O3.H2O","monohydrate","Fluoro-sorafenib, Resihance, Stivarga, regorafaenib monohydrate","O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F",4.174,4,3,6]
["S5078","Osimertinib mesylate","h7","L6200-13","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.",595.71,"1421373-66-1",{"v":9,"d":"9.00"},15.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/osimertinib-mesylate.html","C29H37N7O5S","mesylate","AZD9291 mesylate","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C.C[S](O)(=O)=O",4.257,4,2,10]
["S5079","Sitagliptin","a8","L6200-13","in 10mM DMSO","DPP","Proteases","Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.",407.31,"486460-32-6",{"v":81,"d":"81.00"},198.87,"N/A","N/A","http://selleckchem.com/products/sitagliptin.html","C16H15F6N5O","free base","MK-0431","NC(CC(=O)N1CC[N]2C(=NN=C2C(F)(F)F)C1)CC3=C(F)C=C(F)C(=C3)F",{"v":1.93,"d":"1.930"},3,1,5]
["S5104","Tea polyphenol","b8","L6200-13","in 10mM DMSO","Others","Others","Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.","N/A","84650-60-2",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},{"v":100,"d":"100.00"},"N/A","http://selleckchem.com/products/tea-polyphenol.html","N/A","N/A","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S5105","Proanthocyanidins","c8","L6200-13","in 10mM DMSO","Bacterial","Microbiology","Proanthocyanidins (PAs), also known as condensed tannins, are a class of polyphenols found in a variety of plants. They are very powerful antioxidants that remove harmful free oxygen radicals from cells.",594.52,"20347-71-1",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},"<1","N/A","http://selleckchem.com/products/proanthocyanidins.html","C30H26O13","free base","condensed tannins","OC1C(O)C(OC2CC3=C(OC2C4=CC=C(O)C(=C4)O)C=C(O)C=C3O)(OC5=C1C(=CC(=C5)O)O)C6=CC=C(O)C(=C6)O",{"v":0,"d":"0.000"},0,0,0]
["S5111","7-Ethylcamptothecin","d8","L6200-13","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.",376.41,"78287-27-1",{"v":20,"d":"20.00"},53.13,"N/A","N/A","http://selleckchem.com/products/7-ethylcamptothecin.html","C22H20N2O4","free base","N/A","CCC1=C2C=CC=CC2=NC3=C1CN4C(=O)C5=C(C=C34)C(O)(CC)C(=O)OC5",{"v":0,"d":"0.000"},0,0,0]
["S5113","Propyl gallate","e8","L6200-13","in 10mM DMSO","PPAR","Metabolism","Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.",{"v":212.2,"d":"212.20"},"121-79-9",{"v":42,"d":"42.00"},197.93,"N/A","N/A","http://selleckchem.com/products/propyl-gallate.html","C10H12O5","free base","Gallic acid propyl esterZ, n-Propyl gallate","CCCOC(=O)C1=CC(=C(O)C(=C1)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5121","Phytol","f8","L6200-13","in 10mM DMSO","PPAR","Metabolism","Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.",296.53,"150-86-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/phytol.html","C20H40O","free base","Trans-Phytol","CC(C)CCCC(C)CCCC(C)CCC\\C(C)=C\\CO",{"v":0,"d":"0.000"},0,0,0]
["S5127","Spiculisporic Acid","g8","L6200-13","in 10mM DMSO","Others","Others","Spiculisporic acid (4,5-dicarboxy-4-pentadecanolide) is a bioactive γ-butenolide isolated from a marine Aspergillus.",{"v":328.4,"d":"328.40"},"469-77-2",{"v":65,"d":"65.00"},197.93,"N/A","N/A","http://selleckchem.com/products/spiculisporic-acid.html","C17H28O6","free base","4,5-dicarboxy-4-pentadecanolide","CCCCCCCCCCC(C(O)=O)C1(CCC(=O)O1)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S5133","Sodium erythorbate","h8","L6200-13","in 10mM DMSO","Others","Others","Sodium erythorbate (NaE, D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium) is the sodium of erythorbic acid, a highly refined food-grade chemical closely related to vitamin C, synthesized from sugar, and used as a color fixative in preparing cured meats.",198.11,"6381-77-7",{"v":12,"d":"12.00"},60.57,"N/A","N/A","http://selleckchem.com/products/sodium-erythorbate.html","C6H7O6.Na","sodium salt","D-Isoascorbate, Erythorbic acid sodium salt, Araboascorbic acid monosodium salt, Erbit N, Eribate N, Isoascorbate C sodium, Sodium isoascorbate","OCC(O)C1OC(=O)C(=C1O[Na])O",{"v":0,"d":"0.000"},0,0,0]
["S5144","Neferine","a9","L6200-13","in 10mM DMSO","Akt,Apoptosis related,Autophagy,HIV,NF-κB,Nrf2","NF-κB","Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Neferine strongly inhibits NF-κB activation. Neferine possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.",624.77,"2292-16-2",{"v":100,"d":"100.00"},160.06,"N/A","N/A","http://selleckchem.com/products/neferine.html","C38H44N2O6","free base","(R)-1,2-Dimethoxyaporphine","COC1=CC=C(CC2N(C)CCC3=C2C=C(OC4=CC(=CC=C4O)CC5N(C)CCC6=C5C=C(OC)C(=C6)OC)C(=C3)OC)C=C1",{"v":0,"d":"0.000"},0,0,0]
["S5157","Thymol","b9","L6200-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.",150.22,"89-83-8",{"v":30,"d":"30.00"},199.71,"N/A","N/A","http://selleckchem.com/products/thymol.html","C10H14O","free base","2-isopropyl-5-methylphenol, IPMP","CC(C)C1=CC=C(C)C=C1O",{"v":0,"d":"0.000"},0,0,0]
["S5159","Doxycycline","c9","L6200-13","in 10mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,MMP","Microbiology","Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.",444.43,"564-25-0",{"v":88,"d":"88.00"},198.01,"N/A","N/A","http://selleckchem.com/products/doxycycline.html","C22H24N2O8","free base","Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum","CC1C2C(O)C3C(N(C)C)C(=C(C(N)=O)C(=O)C3(O)C(=C2C(=O)C4=C1C=CC=C4O)O)O",{"v":0,"d":"0.000"},0,0,0]
["S5162","Isovanillic acid","d9","L6200-13","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isovanillic acid (Acide isovanillique, 3-Hydroxyanisic acid, 3-Hydroxy-p-anisic acid), a metabolite of isovanillin, is a selective inhibitor of neutrophil migration into inflamed tissue.",168.15,"645-08-9",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/isovanillic-acid.html","C8H8O4","free base","Acide isovanillique, 3-Hydroxyanisic acid, 3-Hydroxy-p-anisic acid","COC1=C(O)C=C(C=C1)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S5174","Kojic acid","e9","L6200-13","in 10mM DMSO","Fungal,Tyrosinase","Proteases","Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.",142.11,"501-30-4",{"v":28,"d":"28.00"},197.03,"N/A","N/A","http://selleckchem.com/products/kojic-acid.html","C6H6O4","free base","N/A","OCC1=CC(=O)C(=CO1)O",{"v":0,"d":"0.000"},0,0,0]
["S5177","Naproxen","f9","L6200-13","in 10mM DMSO","COX","Immunology & Inflammation","Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2.",230.26,"22204-53-1",{"v":46,"d":"46.00"},199.77,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/naproxen.html","C14H14O3","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(O)=O",2.849,2,0,3]
["S5182","GSK4112","g9","L6200-13","in 10mM DMSO","Others","Metabolism","GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes.",396.89,"1216744-19-2",{"v":68,"d":"68.00"},171.33,{"v":1,"d":"1.00"},2.52,"http://www.selleckchem.com/products/gsk4112.html","C18H21ClN2O4S","Free Base","N/A","CC(C)(C)OC(=O)CN(CC1=CC=C(S1)[N+]([O-])=O)CC2=CC=C(Cl)C=C2",4.548,2,0,9]
["S5200","Diaveridine","h9","L6200-13","in 10mM DMSO","DHFR","Metabolism","Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.",260.29,"5355-16-8",{"v":25,"d":"25.00"},96.05,"N/A","N/A","http://selleckchem.com/products/diaveridine.html","C13H16N4O2","free base","AI3-23935, CCRIS-3784","COC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1",1.559,4,2,4]
["S5221","Diludine","a10","L6200-13","in 10mM DMSO","Others","Others","Diludine (Ethidine, Diethone) is a synthetic antioxidant agent.",253.29,"1149-23-1",{"v":28,"d":"28.00"},110.54,{"v":-1,"d":"-1.00"},-3.95,"https://www.selleckchem.com/products/diludine.html","C13H19NO4","Esters","Ethidine, Diethone","CCOC(=O)C1=C(C)NC(=C(C1)C(=O)OCC)C",1.285,4,1,6]
["S5229","Isosorbide dinitrate","b10","L6200-13","in 10mM DMSO","Guanylate Cyclase,NOS","Immunology & Inflammation","Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).",236.14,"87-33-2",{"v":47,"d":"47.00"},199.03,"N/A","N/A","http://selleckchem.com/products/isosorbide-dinitrate.html","C6H8N2O8","free base","Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide","[O-][N+](=O)OC1COC2C(COC12)O[N+]([O-])=O",3.413,4,0,4]
["S5233","Fenretinide (NSC 374551)","c10","L6200-13","in 10mM DMSO","Retinoid Receptor","Metabolism","Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.",391.55,"65646-68-6",{"v":78,"d":"78.00"},199.21,"<1","N/A","http://selleckchem.com/products/fenretinide.html","C26H33NO2","free base","4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016","CC1=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(=O)NC2=CC=C(O)C=C2)C(C)(C)CCC1",6.463,1,2,6]
["S5242","Cediranib Maleate","d10","L6200-13","in 10mM DMSO","VEGFR","Protein Tyrosine Kinase","Cediranib Maleate (AZD-2171) is the maleate salt of Cediranib, which is a potent inhibitor of VEGFR with IC50 of <1 nM and also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.",566.58,"857036-77-2",{"v":100,"d":"100.00"},{"v":176.5,"d":"176.50"},"<1","N/A","http://selleckchem.com/products/cediranib-maleate.html","C25H27FN4O3.C4H4O4","maleate","AZD-2171 maleate","COC1=CC2=C(OC3=C(F)C4=C([NH]C(=C4)C)C=C3)N=CN=C2C=C1OCCCN5CCCC5.OC(=O)\\C=C/C(O)=O",1.765,7,1,10]
["S5243","Ruxolitinib Phosphate","e10","L6200-13","in 10mM DMSO","Apoptosis related,Autophagy,JAK,Mitophagy","JAK/STAT","Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.",404.36,"1092939-17-7",{"v":80,"d":"80.00"},197.84,{"v":29,"d":"29.00"},71.72,"http://selleckchem.com/products/ruxolitinib-phosphate.html","C17H18N6.H3O4P","phosphate","INCB018424, INC424","O[P](O)(O)=O.N#CCC(C1CCCC1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4",2.412,3,1,4]
["S5250","Darunavir","f10","L6200-13","in 10mM DMSO","COVID-19,HIV Protease","Proteases","Darunavir (TMC114,DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.",547.66,"206361-99-1",{"v":100,"d":"100.00"},{"v":182.6,"d":"182.60"},"<1","N/A","http://selleckchem.com/products/darunavir.html","C27H37N3O7S","free base","TMC114,DRV","CC(C)CN(CC(O)C(CC1=CC=CC=C1)NC(=O)OC2COC3OCCC23)[S](=O)(=O)C4=CC=C(N)C=C4",2.631,6,3,12]
["S5254","Dasatinib hydrochloride","g10","L6200-13","in 10mM DMSO","Bcr-Abl,kit,Src","Angiogenesis","Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.",524.47,"854001-07-3",{"v":100,"d":"100.00"},190.67,{"v":11,"d":"11.00"},20.97,"https://www.selleckchem.com/products/dasatinib-hydrochloride.html","C22H27Cl2N7O2S","hydrochloride","BMS-354825 HCl","Cl.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4",3.821,4,3,7]
["S5265","TBB","h10","L6200-13","in 10mM DMSO","Casein Kinase","Metabolism","TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.",434.71,"17374-26-4",{"v":86,"d":"86.00"},197.83,{"v":-1,"d":"-1.00"},{"v":-2.3,"d":"-2.30"},"http://selleckchem.com/products/tbb.html","C6HBr4N3","Benzotriazoles","4,5,6,7-tetrabromobenzotriazole","BrC1=C(Br)C2=C(N=N[NH]2)C(=C1Br)Br",4.428,2,1,0]
["S5266","Stiripentol","a11","L6200-13","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.",234.29,"49763-96-4",{"v":46,"d":"46.00"},196.34,{"v":13,"d":"13.00"},55.49,"http://selleckchem.com/products/stiripentol.html","C14H18O3","Dioxolane","BCX2600","CC(C)(C)C(O)/C=C/C1=CC=C2OCOC2=C1",2.955,2,1,3]
["S5284","Adenosine 5'-monophosphate monohydrate","b11","L6200-13","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).",365.24,"18422-05-4",{"v":9,"d":"9.00"},24.64,"N/A","N/A","http://selleckchem.com/products/adenosine-5-monophosphate-monohydrate.html","C10H14N5O7P.H2O","hydrate","5'-Adenylic acid, 5'-AMP","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(O)=O)C(O)C3O",{"v":-2.16,"d":"-2.160"},5,3,4]
["S5293","Nimustine Hydrochloride","c11","L6200-13","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Nimustine Hydrochloride (Nidran) is the hydrochloride salt of nimustine, a nitrosourea with antineoplastic activity that alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death.",309.15,"55661-38-6",{"v":61,"d":"61.00"},197.32,"N/A","N/A","http://selleckchem.com/products/nimustine-hydrochloride.html","C9H13ClN6O2.HCl","hydrochloride","Nidran hydrochloride","Cl.CC1=NC=C(CNC(=O)N(CCCl)N=O)C(=N1)N",{"v":0.47,"d":"0.470"},4,2,5]
["S5297","Vidarabine monohydrate","d11","L6200-13","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Vidarabine (Spongoadenosine, Vira-A) is a nucleoside antibiotic with antiviral acitivity that interferes with the synthesis of viral DNA. It is used to treat herpes simplex and varicella zoster viruses.",285.26,"24356-66-9",{"v":57,"d":"57.00"},199.82,"N/A","N/A","http://selleckchem.com/products/vidarabine-monohydrate.html","C10H13N5O4.H2O","hydrate","Spongoadenosine monohydrate, Vira-A monohydrate","O.NC1=NC=NC2=C1N=C[N]2C3OC(CO)C(O)C3O",-2.088,4,4,2]
["S5304","2-Acetylphenothiazine (ML171)","e11","L6200-13","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.",241.31,"6631-94-3",{"v":48,"d":"48.00"},198.91,"N/A","N/A","http://selleckchem.com/products/2-acetylphenothiazine-ml171.html","C14H11NOS","free base","2-APT","CC(=O)C1=CC=C2SC3=C(NC2=C1)C=CC=C3",3.408,1,1,1]
["S5307","PSI-6206 (GS-331007)","f11","L6200-13","in 10mM DMSO","HCV Protease","Proteases","PSI-6206 (RO-2433, GS-331007) is a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase, targeting NS5B polymerase.",260.22,"863329-66-2",{"v":52,"d":"52.00"},199.83,{"v":52,"d":"52.00"},199.83,"http://selleckchem.com/products/psi-6206-ro-2433-gs-331007.html","C10H13FN2O5","free base","RO-2433","CC1(F)C(O)C(CO)OC1N2C=CC(=O)NC2=O",-1.306,3,3,2]
["S5309","Propyphenazone (4-Isopropylantipyrine)","g11","L6200-13","in 10mM DMSO","COX","Immunology & Inflammation","Propyphenazone(4-Isopropylantipyrine, Isopropyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.",230.31,"479-92-5",{"v":46,"d":"46.00"},199.73,"N/A","N/A","http://selleckchem.com/products/propyphenazone.html","C14H18N2O","free base","Isopropylantipyrine, Isopropyrine","CC(C)C1=C(C)N(C)N(C2=CC=CC=C2)C1=O",2.373,1,0,2]
["S5312","Urolithin A","h11","L6200-13","in 10mM DMSO","Mitophagy","Autophagy","Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.",{"v":228.2,"d":"228.20"},"1143-70-0",{"v":45,"d":"45.00"},{"v":197.2,"d":"197.20"},"<1","N/A","http://selleckchem.com/products/urolithin-a.html","C13H8O4","free base","3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin","OC1=CC=C2C(=C1)OC(=O)C3=CC(=CC=C23)O",2.466,2,2,0]
["S5313","SC66","a2","L6200-14","in 10mM DMSO","Akt","PI3K/Akt/mTOR","SC66 is an allosteric inhibitor which displays a dual-inhibitory function toward AKT activity with IC50 values of 0.77, 2.85 and 0.47 μg/ml in HepG2, Huh7 and Hep3B cells after 72 h treatment, respectively.",276.33,"871361-88-5",{"v":55,"d":"55.00"},199.04,"N/A","N/A","http://selleckchem.com/products/sc66.html","C18H16N2O","free base","N/A","O=C1C(/CCC\\C1=C/C2=CC=NC=C2)=C/C3=CC=NC=C3",2.836,3,0,2]
["S5314","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone)","b2","L6200-14","in 10mM DMSO","ROS","Immunology & Inflammation","HTHQ (1-O-Hexyl-2,3,5-trimethylhydroquinone), which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent. HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone) has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS), including peroxyl radicals, and scavenging them to form more stable free radicals.",236.35,"148081-72-5",{"v":47,"d":"47.00"},198.86,"N/A","N/A","http://selleckchem.com/products/hthq-1-o-hexyl-2-3-5-trimethylhydroquinone.html","C15H24O2","Hydroquinones","N/A","CCCCCCOC1=CC(=C(O)C(=C1C)C)C",5.271,1,1,6]
["S5315","PRT4165","c2","L6200-14","in 10mM DMSO","BMI-1,E3 Ligase","Ubiquitin","PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.",235.24,"31083-55-3",{"v":11,"d":"11.00"},46.76,"<1","N/A","http://selleckchem.com/products/prt4165.html","C15H9NO2","free base","N/A","O=C1C2=C(C=CC=C2)C(=O)C1=CC3=CC=CN=C3",2.085,3,0,1]
["S5316","NU2058","d2","L6200-14","in 10mM DMSO","CDK","Cell Cycle","NU2058 (O(6)-Cyclohexylmethylguanine) is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.",{"v":247.3,"d":"247.30"},"161058-83-9",{"v":49,"d":"49.00"},198.14,"<1","N/A","http://selleckchem.com/products/nu2058.html","C12H17N5O","free base","O(6)-Cyclohexylmethylguanine","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3CCCCC3",2.251,4,2,3]
["S5317","UK 5099","e2","L6200-14","in 10mM DMSO","Mitochondrial pyruvate carrier","Metabolism","UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier, inhibiting pyruvate transport across the plasma membrane of trypanosomes with Ki value of 49 μM.",{"v":288.3,"d":"288.30"},"56396-35-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/uk5099.html","C18H12N2O2","Mitochondrial pyruvate carrier","PF-1005023","OC(=O)\\C(=C\\C1=C[N](C2=CC=CC=C2)C3=C1C=CC=C3)C#N",3.842,1,0,3]
["S5318","Acacetin","f2","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.",284.26,"480-44-4",{"v":56,"d":"56.00"},{"v":197,"d":"197.00"},"N/A","N/A","http://selleckchem.com/products/acacetin.html","C16H12O5","free base","Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3O",2.636,3,2,2]
["S5325","Nitisinone","g2","L6200-14","in 10mM DMSO","Others","Metabolism","Nitisinone (NTBC, Nitisone, SC0735) is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.",329.23,"104206-65-7",{"v":65,"d":"65.00"},197.43,"<1","N/A","http://selleckchem.com/products/nitisinone.html","C14H10F3NO5","free base","NTBC, Nitisone, SC0735","[O-][N+](=O)C1=CC(=CC=C1C(=O)C2C(=O)CCCC2=O)C(F)(F)F",{"v":2.53,"d":"2.530"},3,0,4]
["S5343","Vanillic acid","h2","L6200-14","in 10mM DMSO","NF-κB","NF-κB","Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects.",168.15,"121-34-6",{"v":33,"d":"33.00"},196.25,"N/A","N/A","http://selleckchem.com/products/vanillic-acid.html","C8H8O4","free base","4-hydroxy-3-methoxybenzoic acid","COC1=C(O)C=CC(=C1)C(O)=O",1.201,2,1,2]
["S5345","(+/-)-nerolidol","a3","L6200-14","in 10mM DMSO","Parasite","Microbiology","(+/-)-nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.",222.37,"7212-44-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/nerolidol.html","C15H26O","free base","Peruviol","CC(C)=CCC/C(C)=C/CCC(C)(O)C=C",4.561,0,0,7]
["S5357","Safinamide","b3","L6200-14","in 10mM DMSO","MAO","Metabolism","Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible <v>monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.",302.34,"133865-89-1",{"v":60,"d":"60.00"},198.45,{"v":-1,"d":"-1.00"},-3.31,"http://selleckchem.com/products/safinamide.html","C17H19FN2O2","free base","EMD-1195686, PNU-15774E","CC(NCC1=CC=C(OCC2=CC=CC(=C2)F)C=C1)C(N)=O",2.478,2,2,7]
["S5365","Alogliptin","c3","L6200-14","in 10mM DMSO","DPP","Proteases","Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.",339.39,"850649-61-5",{"v":67,"d":"67.00"},197.41,{"v":18,"d":"18.00"},53.04,"http://selleckchem.com/products/alogliptin.html","C18H21N5O2","Dipeptidyl Peptidase-4","SYR 322","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC=CC=C3C#N)C1=O",1.271,2,1,3]
["S5366","Fipronil","d3","L6200-14","in 10mM DMSO","Anti-infection","Microbiology","Fipronil (Fluocyanobenpyrazole, Termidor) is a recalcitrant phenylpyrazole-based pesticide used for flea/tick treatment and termite control that is distributed in urban aquatic environments via stormwater and contributes to stream toxicity.",437.15,"120068-37-3",{"v":87,"d":"87.00"},199.02,"N/A","N/A","http://selleckchem.com/products/fipronil.html","C12H4Cl2F6N4OS","free base","Fluocyanobenpyrazole, Termidor","NC1=C(C(=N[N]1C2=C(Cl)C=C(C=C2Cl)C(F)(F)F)C#N)[S](=O)C(F)(F)F",5.579,2,1,4]
["S5369","Ethoxyquin","e3","L6200-14","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Ethoxyquin (Santoquin, Santoflex, Quinol) is an antioxidant used as a food preservative.  Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).",217.31,"91-53-2","The physical form of the compound is liquid, which can be dissolved in any proportion.",{"v":10,"d":"10.00"},"N/A","N/A","http://selleckchem.com/products/ethoxyquin.html","C14H19NO","free base","Santoquin, Santoflex, Quinol","CCOC1=CC2=C(NC(C)(C)C=C2C)C=C1",3.221,1,1,2]
["S5373","Pseudolaric Acid B","f3","L6200-14","in 10mM DMSO","Fungal","Microbiology","Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.",432.46,"82508-31-4",{"v":86,"d":"86.00"},198.86,"<1","N/A","https://www.selleckchem.com/products/pseudolaric-acid-b.html","C23H28O8","Diterpenoids","N/A","COC(=O)C1=CCC23CCC(C(C)(OC2=O)\\C=C\\C=C(C)\\C(O)=O)C3(CC1)OC(C)=O",2.793,7,0,7]
["S5380","7-Hydroxyflavone","g3","L6200-14","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2. It also has excellent antioxidant properties and great potential to be applied as medicines.",238.24,"6665-86-7",{"v":47,"d":"47.00"},197.28,"N/A","N/A","http://selleckchem.com/products/7-hydroxyflavone.html","C15H10O3","free base","N/A","OC1=CC=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3",2.894,2,1,1]
["S5383","Erucic acid","h3","L6200-14","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Erucic acid (cis-13-docosenoic acid) is a monounsaturated omega-9 fatty acid used as mineral oil and a precursor to biodiesel fuel.",338.57,"112-86-7",{"v":67,"d":"67.00"},197.89,"N/A","N/A","http://selleckchem.com/products/erucic-acid.html","C22H42O2","free base","cis-13-docosenoic acid","CCCCCCCC\\C=C/CCCCCCCCCCCC(O)=O",8.685,1,0,19]
["S5388","Betrixaban","a4","L6200-14","in 10mM DMSO","Factor Xa","Metabolism","Betrixaban is a new, long-acting, oral and selective Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.",451.91,"330942-05-7",{"v":35,"d":"35.00"},77.45,"<1","N/A","https://www.selleckchem.com/products/betrixaban.html","C23H22ClN5O3","free base","PRT054021","COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC3=CC=C(Cl)C=N3",2.904,4,2,7]
["S5389","Betrixaban maleate","b4","L6200-14","in 10mM DMSO","Factor Xa","Metabolism","Betrixaban maleate is the maleate salt form of Betrixaban, which is a Factor Xa inhibitor that decreases prothrombinase activity and thrombin generation.",567.98,"936539-80-9",{"v":100,"d":"100.00"},176.06,{"v":1,"d":"1.00"},1.76,"https://www.selleckchem.com/products/betrixaban-maleate.html","C23H22ClN5O3.C4H4O4","maleate","N/A","COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC3=CC=C(Cl)C=N3.OC(=O)\\C=C/C(O)=O",2.943,6,2,9]
["S5394","Tizoxanide","c4","L6200-14","in 10mM DMSO","HCV Protease","Microbiology","Tizoxanide (Desacetyl-nitazoxanide), a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C.",265.25,"173903-47-4",{"v":27,"d":"27.00"},101.79,"<1","N/A","http://selleckchem.com/products/tizoxanide.html","C10H7N3O4S","free base","Desacetyl-nitazoxanide","OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+]([O-])=O",1.388,2,2,3]
["S5402","Dasabuvir (ABT-333)","d4","L6200-14","in 10mM DMSO","HCV Protease","Proteases","Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.",493.57,"1132935-63-7",{"v":98,"d":"98.00"},198.55,"<1","N/A","http://selleckchem.com/products/dasabuvir-abt-333.html","C26H27N3O5S","free base","N/A","COC1=C(C=C(C=C1C2=CC3=CC=C(N[S](C)(=O)=O)C=C3C=C2)N4C=CC(=O)NC4=O)C(C)(C)C",3.492,5,2,6]
["S5403","Ombitasvir (ABT-267)","e4","L6200-14","in 10mM DMSO","HCV Protease","Proteases","Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.",894.11,"1258226-87-7",{"v":100,"d":"100.00"},111.84,"N/A","N/A","http://selleckchem.com/products/ombitasvir-abt-267.html","C50H67N7O8","free base","N/A","COC(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC2=CC=C(C=C2)C3CCC(N3C4=CC=C(C=C4)C(C)(C)C)C5=CC=C(NC(=O)C6CCCN6C(=O)C(NC(=O)OC)C(C)C)C=C5",7.103,8,4,16]
["S5404","Paritaprevir (ABT-450)","f4","L6200-14","in 10mM DMSO","HCV Protease","Proteases","Paritaprevir (ABT-450) is a nonstructural (NS) protein 3/4A protease inhibitor.",765.88,"1216941-48-8",{"v":100,"d":"100.00"},130.57,"N/A","N/A","http://selleckchem.com/products/paritaprevir-abt-450.html","C40H43N7O7S","free base","N/A","CC1=NC=C(N=C1)C(=O)NC2CCCCC\\C=C/C3CC3(NC(=O)C4CC(CN4C2=O)OC5=NC6=C(C=CC=C6)C7=C5C=CC=C7)C(=O)N[S](=O)(=O)C8CC8",3.104,10,3,7]
["S5416","Metyrapone","g4","L6200-14","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.",226.27,"54-36-4",{"v":46,"d":"46.00"},203.29,{"v":-1,"d":"-1.00"},-4.42,"https://www.selleckchem.com/products/metyrapone.html","C14H14N2O","free base","NSC-25265, SU-4885","CC(C)(C1=CC=CN=C1)C(=O)C2=CC=CN=C2",1.847,3,0,3]
["S5418","Parecoxib Sodium","h4","L6200-14","in 10mM DMSO","COX","Immunology & Inflammation","Parecoxib Sodium (SC-69124) is a water-soluble, injectable sodium salt form of parecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2 (COX2).",{"v":392.4,"d":"392.40"},"198470-85-8",{"v":78,"d":"78.00"},198.77,{"v":-1,"d":"-1.00"},-2.55,"https://www.selleckchem.com/products/parecoxib-sodium.html","C19H17N2NaO4S","free base","SC-69124 Sodium","CCC(=O)N([Na])[S](=O)(=O)C1=CC=C(C=C1)C2=C(C)ON=C2C3=CC=CC=C3",{"v":3.36,"d":"3.360"},5,0,5]
["S5425","Phenylglyoxal hydrate","a5","L6200-14","in 10mM DMSO","Dehydrogenase","Metabolism","Phenylglyoxal (1-Phenylethanedione) is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.",152.15,"1075-06-5",{"v":30,"d":"30.00"},197.17,"N/A","N/A","http://selleckchem.com/products/phenylglyoxal-hydrate.html","C8H8O3","free base","1-Phenylethanedione hydrate","OC(O)C(=O)C1=CC=CC=C1",0.777,1,0,2]
["S5426","Bromopyruvic acid","b5","L6200-14","in 10mM DMSO","Carbohydrate Metabolism","Metabolism","Bromopyruvic acid (3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.",166.96,"1113-59-3",{"v":33,"d":"33.00"},197.65,"N/A","N/A","http://selleckchem.com/products/bromopyruvic-acid.html","C3H3BrO3","free base","3-Bromopyruvic acid, 3-Bromopyruvate, Bromopyruvic acid, Hexokinase II Inhibitor II, 3-BP","OC(=O)C(=O)CBr",0.348,2,0,2]
["S5434","AS057278","c5","L6200-14","in 10mM DMSO","Others","Neuronal Signaling","AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).",126.11,"402-61-9",{"v":25,"d":"25.00"},198.24,"N/A","N/A","http://selleckchem.com/products/as057278.html","C5H6N2O2","free base","3-Methylpyrazole-5-carboxylic acid","CC1=CC(=N[NH]1)C(O)=O",0.477,2,1,1]
["S5438","Biphenyl-4-sulfonyl chloride","d5","L6200-14","in 10mM DMSO","HDAC","Epigenetics","Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.",252.72,"1623-93-4",{"v":50,"d":"50.00"},197.85,"N/A","N/A","http://selleckchem.com/products/biphenyl-4-sulfonyl-chloride.html","C12H9ClO2S","free base","p-Phenylbenzenesulfonyl chloride, 4-Phenylbenzenesulfonyl chloride, p-Biphenylsulfonyl chloride","Cl[S](=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2",3.257,2,0,2]
["S5439","5-Bromoindole","e5","L6200-14","in 10mM DMSO","GSK-3","Stem Cells & Wnt","5-bromoindole is an important pharmaceutical chemical intermediate and a potential inhibitor of glycogen synthase kinase 3 (GSK-3).",196.04,"10075-50-0",{"v":39,"d":"39.00"},198.94,"N/A","N/A","http://selleckchem.com/products/5-bromoindole.html","C8H6BrN","free base","N/A","BrC1=CC2=C([NH]C=C2)C=C1",2.871,0,1,0]
["S5440","Berberine Sulfate","f5","L6200-14","in 10mM DMSO","Bacterial","Microbiology","Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.",433.43,"633-66-9",{"v":20,"d":"20.00"},46.14,"N/A","N/A","http://selleckchem.com/products/berberine-sulfate.html","C20H18NO4.HO4S","sulfate","Umbellatine Sulfate","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4.O[S]([O-])(=O)=O",1.111,4,0,2]
["S5445","AMI-1 (free acid)","g5","L6200-14","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.",504.49,"134-47-4",{"v":20,"d":"20.00"},39.64,"N/A","N/A","http://selleckchem.com/products/ami-1-free-acid.html","C21H16N2O9S2","free base","N/A","OC1=C2C=CC(=CC2=CC(=C1)[S](O)(=O)=O)NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)[S](O)(=O)=O",2.521,1,4,4]
["S5450","Sofalcone","h5","L6200-14","in 10mM DMSO","Others","Others","Sofalcone (SU-88) is an antiulcer drug and a mucosal protective agent, increasing vascular endothelual growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.",450.52,"64506-49-6",{"v":90,"d":"90.00"},199.77,{"v":-1,"d":"-1.00"},-2.22,"https://www.selleckchem.com/products/sofalcone.html","C27H30O6","free base","SU-88","CC(C)=CCOC1=CC=C(/C=C/C(=O)C2=C(OCC(O)=O)C=C(OCC=C(C)C)C=C2)C=C1",6.065,5,0,12]
["S5451","Ferulic acid methyl ester","a6","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ferulic acid methyl ester (Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate) is a lipophilic derivative of ferulic acid,  which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.",208.21,"2309-07-1",{"v":41,"d":"41.00"},196.92,{"v":41,"d":"41.00"},196.92,"http://selleckchem.com/products/ferulic-acid-methylester.html","C11H12O4","free base","Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate","COC(=O)\\C=C\\C1=CC=C(O)C(=C1)OC",1.894,3,1,4]
["S5452","Sanguinarine chloride","b6","L6200-14","in 10mM DMSO","phosphatase,ROS","Immunology & Inflammation","Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.",367.78,"5578-73-4",{"v":5,"d":"5.00"},{"v":13.6,"d":"13.60"},"<1","N/A","http://selleckchem.com/products/sanguinarine-chloride.html","C20H14NO4.Cl","chloride","N/A","[Cl-].C[N+]1=CC2=C3OCOC3=CC=C2C4=CC=C5C=C6OCOC6=CC5=C14",1.313,4,0,0]
["S5453","Hyperoside","c6","L6200-14","in 10mM DMSO","NF-κB","NF-κB","Hyperoside (Hyperin, Quercetin 3-galactoside), a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.Hyperoside can inhibit activation of the NF-κB signaling pathway.",464.38,"482-36-0",{"v":92,"d":"92.00"},198.11,{"v":1,"d":"1.00"},2.15,"http://selleckchem.com/products/hyperoside.html","C21H20O12","free base","Hyperin, Quercetin 3-galactoside","OCC1OC(OC2=C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S5454","Saikosaponin D","d6","L6200-14","in 10mM DMSO","ATPase","Transmembrane Transporters","Saikosaponin D, a calcium mobilizing agent (SERCA inhibitor), is a type of Saponin derivative, which is a component extracted from Bupleurum falactum. Saikosaponin D has anti-cancer activities.",780.98,"20874-52-6",{"v":100,"d":"100.00"},128.04,"<1","N/A","http://selleckchem.com/products/saikosaponin-d.html","C42H68O13","free base","N/A","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O",1.107,5,8,6]
["S5456","Isobavachalcone","e6","L6200-14","in 10mM DMSO","Bacterial","Microbiology","Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.",324.37,"20784-50-3",{"v":64,"d":"64.00"},197.31,"<1","N/A","http://selleckchem.com/products/isobavachalcone.html","C20H20O4","free base","Corylifolinin","CC(C)=CCC1=C(O)C(=CC=C1O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.832,1,3,5]
["S5457","Curculigoside","f6","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Curculigoside (Curculigoside A), a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.",466.44,"85643-19-2",{"v":93,"d":"93.00"},199.38,{"v":15,"d":"15.00"},32.16,"http://selleckchem.com/products/curculigoside.html","C22H26O11","free base","Curculigoside A","COC1=C(C(=O)OCC2=CC(=CC=C2OC3OC(CO)C(O)C(O)C3O)O)C(=CC=C1)OC",0.822,6,5,9]
["S5458","Verbascoside","g6","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Verbascoside (Acteoside, Kusaginin), a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.",624.59,"61276-17-3",{"v":100,"d":"100.00"},160.11,{"v":100,"d":"100.00"},160.11,"http://selleckchem.com/products/verbascoside.html","C29H36O15","free base","Acteoside, Kusaginin","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(CO)C2OC(=O)\\C=C\\C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",0.484,6,9,11]
["S5460","Vitexin-2-O-rhaMnoside","h6","L6200-14","in 10mM DMSO","Others","Others","Vitexin-2-O-rhamnoside (2''-O-Rhamnosylvitexin, Apigenin-8-C-glucoside) is one of the main components of flavonoid of the leaves of Crataegus pinnatifida Bge. var major N. E. Br. It has many biological and pharmacological activities, such as antioxidation and treating heart disease.",578.52,"64820-99-1",{"v":100,"d":"100.00"},172.85,{"v":100,"d":"100.00"},172.85,"http://selleckchem.com/products/vitexin-2-o-rhamnoside.html","C27H30O14","free base","2''-O-Rhamnosylvitexin, Apigenin-8-C-glucoside","CC1OC(OC2C(O)C(O)C(CO)OC2C3=C(O)C=C(O)C4=C3OC(=CC4=O)C5=CC=C(O)C=C5)C(O)C(O)C1O",{"v":-0.84,"d":"-0.840"},5,9,5]
["S5464","Psoralidin","a7","L6200-14","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Psoralidin, a naturally occurring coumestan isolated from the fractions of organic solvents such as ethylacetate, hexane, or n-butanol of the seed extract of Psoralea corylifolia L., has a variety of biological activities such as anticancer, antioxidant, antibacterial, antidepressant, anti-inflammatory activities, and regulation of insulin signaling. It is an agonist for both estrogen receptor (ER)α and ERβ with binding affinities (IC50s) of 1.03 and 24.6 μM, respectively.",336.34,"18642-23-4",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/psoralidin.html","C20H16O5","free base","N/A","CC(C)=CCC1=CC2=C(OC(=O)C3=C2OC4=C3C=CC(=C4)O)C=C1O",4.917,3,2,2]
["S5465","Morroniside","b7","L6200-14","in 10mM DMSO","MMP,Pyroptosis","Proteases","Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.",406.38,"25406-64-8",{"v":81,"d":"81.00"},199.32,{"v":81,"d":"81.00"},199.32,"http://selleckchem.com/products/morroniside.html","C17H26O11","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)OC(O)CC13",{"v":-2.28,"d":"-2.280"},6,4,5]
["S5466","Saikosaponin A","c7","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.",780.98,"20736-09-8",{"v":100,"d":"100.00"},128.04,"<1","N/A","https://www.selleckchem.com/products/saikosaponin-a.html","C42H68O13","free base","N/A","CC1OC(OC2CCC3(C)C(CCC4(C)C3C=CC56OCC7(CCC(C)(C)CC57)C(O)CC46C)C2(C)CO)C(O)C(OC8OC(CO)C(O)C(O)C8O)C1O",1.107,5,8,6]
["S5484","Rimantadine Hydrochloride","d7","L6200-14","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rimantadine is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.",215.76,"1501-84-4",{"v":43,"d":"43.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","http://selleckchem.com/products/rimantadine-hydrochloride.html","C12H21N.HCl","hydrochloride","N/A","Cl.CC(N)[C]12C[CH]3C[CH]([CH2]C([CH2]3)C1)C2",2.586,0,1,1]
["S5502","Ilaprazole sodium","e7","L6200-14","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Ilaprazole (IY-81149) sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H(+)/K(+)-ATPase in a dose-dependent manner with IC50 of 6 μM in rabbit parietal cell preparation.",388.42,"172152-50-0",{"v":78,"d":"78.00"},200.81,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/iiaprazole-sodium.html","C19H17N4NaO2S","Sodium Salt","IY-81149 sodium","COC1=C(C)C(=NC=C1)C[S](=O)C2=NC3=C(C=CC(=C3)[N]4C=CC=C4)[N]2[Na]",3.414,4,0,5]
["S5520","Phenidone","f7","L6200-14","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.",162.19,"92-43-3",{"v":32,"d":"32.00"},{"v":197.3,"d":"197.30"},"N/A","N/A","http://selleckchem.com/products/phenidone.html","C9H10N2O","free base","1-phenyl-3-pyrazolidinone","O=C1CCN(N1)C2=CC=CC=C2",1.112,1,1,1]
["S5529","Galangin","g7","L6200-14","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Galangin (3,5,7-trihydroxyflavone; Norizalpinin), a naturally occuring flavonoid found in herbs, is a well-known antioxidant and also an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor.",270.24,"548-83-4",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/galangin.html","C15H10O5","free base","3,5,7-trihydroxyflavone; Norizalpinin","OC1=CC2=C(C(=C1)O)C(=O)C(=C(O2)C3=CC=CC=C3)O",2.114,2,3,1]
["S5550","Ethyl gallate","h7","L6200-14","in 10mM DMSO","Bcl-2,Caspase","Apoptosis","Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8, -9, and -3 and the Bcl-2 interacting domain (Bid).",198.17,"831-61-8",{"v":39,"d":"39.00"},{"v":196.8,"d":"196.80"},"N/A","N/A","https://www.selleckchem.com/products/ethyl-gallate.html","C9H10O5","Ester","Phyllemblin, gallic acid ethyl ester","CCOC(=O)C1=CC(=C(O)C(=C1)O)O",1.308,2,3,3]
["S5551","6-Paradol","a8","L6200-14","in 10mM DMSO","COX","Immunology & Inflammation","6-Paradol is a minor constituent of ginger, mainly formed from 6-gingerol via 6-shogaol, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities. Paradol is an inhibitor of cyclooxygenase (COX)-2.",278.39,"27113-22-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/6-paradol.html","C17H26O3","free base","N/A","CCCCCCCC(=O)CCC1=CC=C(O)C(=C1)OC",{"v":4.74,"d":"4.740"},2,1,10]
["S5552","Amenamevir","b8","L6200-14","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.",482.55,"841301-32-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/amenamevir.html","C24H26N4O5S","free base","ASP2151","CC1=C(N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CC[S](=O)(=O)CC4)C(=CC=C1)C",{"v":2.24,"d":"2.240"},7,1,6]
["S5554","Lanatoside C","c8","L6200-14","in 10mM DMSO","Akt,Antiviral,Apoptosis related,Autophagy,JAK,mTOR,PI3K,STAT,Wnt/beta-catenin","Immunology & Inflammation","Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.",985.12,"17575-22-3","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/lanatoside-c.html","C49H76O20","free base","N/A","CC1OC(CC(O)C1OC2CC(O)C(OC3CC(OC(C)=O)C(OC4OC(CO)C(O)C(O)C4O)C(C)O3)C(C)O2)OC5CCC6(C)C(CCC7C6CC(O)C8(C)C(CCC78O)C9=CC(=O)OC9)C5",0.631,12,7,12]
["S5561","Ethacrynic Acid","d8","L6200-14","in 10mM DMSO","Others","NF-κB","Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.",303.14,"58-54-8",{"v":61,"d":"61.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ethacrynic-acid.html","C13H12Cl2O4","Free Base","N/A","CCC(=C)C(=O)C1=C(Cl)C(=C(OCC(O)=O)C=C1)Cl",3.963,3,0,6]
["S5563","Thioridazine hydrochloride","e8","L6200-14","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Thioridazine (Aldazine, Mellaril) is a potent antianxiety and antipsychotic agent.",407.04,"130-61-0",{"v":81,"d":"81.00"},{"v":199,"d":"199.00"},"N/A","N/A","http://selleckchem.com/products/thioridazine-hydrochloride.html","C21H26N2S2.HCl","hydrochloride","Aldazine, Mellaril","Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC4CCCCN4C)C=C1",5.945,0,0,4]
["S5565","Triflupromazine hydrochloride","f8","L6200-14","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Triflupromazine hydrochloride (Fluopromazine) is an antipsychotic medication of the phenothiazine class.",388.88,"1098-60-8",{"v":78,"d":"78.00"},200.58,"N/A","N/A","https://www.selleckchem.com/products/triflupromazine-hydrochloride.html","C18H20ClF3N2S","salt","Fluopromazine hydrochloride","Cl.CN(C)CCCN1C2=C(SC3=CC=C(C=C13)C(F)(F)F)C=CC=C2",5.399,0,0,5]
["S5575","2-Benzoxazolinone","g8","L6200-14","in 10mM DMSO","Others","Others","2-Benzoxazolinone (BOA, 2-Hydroxybenzoxazole), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate and probably functions via interfering with auxins or disrupting membrane integrity.",135.12,"59-49-4",{"v":27,"d":"27.00"},199.82,"N/A","N/A","http://selleckchem.com/products/2-benzoxazolinone.html","C7H5NO2","free base","2-Hydroxybenzoxazole","O=C1NC2=C(O1)C=CC=C2",{"v":1.34,"d":"1.340"},2,1,0]
["S5579","Chelidonic acid","h8","L6200-14","in 10mM DMSO","Caspase,Decarboxylase,Immunology & Inflammation related,Interleukins,NF-κB","Immunology & Inflammation","Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.",{"v":184.1,"d":"184.10"},"99-32-1",{"v":4,"d":"4.00"},21.73,"N/A","N/A","http://selleckchem.com/products/chelidonic-acid.html","C7H4O6","free base","Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid","OC(=O)C1=CC(=O)C=C(O1)C(O)=O",-0.479,4,0,2]
["S5582","Cytarabine hydrochloride","a9","L6200-14","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA.",279.68,"69-74-9",{"v":55,"d":"55.00"},196.65,"N/A","N/A","http://selleckchem.com/products/cytarabine-hydrochloride.html","C9H13N3O5.HCl","hydrochloride","N/A","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.014,3,4,2]
["S5595","3-Carene","b9","L6200-14","in 10mM DMSO","COX,phosphatase","Immunology & Inflammation","3-Carene (Carene, Delta-3-Carene) is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.",136.23,"13466-78-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/3-carene.html","C10H16","free base","Carene, Delta-3-Carene","CC1=CCC2C(C1)C2(C)C",2.872,0,0,0]
["S5604","Diphenylamine Hydrochloride","c9","L6200-14","in 10mM DMSO","OXPHOS","Apoptosis","Diphenylamine (N-Phenylbenzenamine, Anilinobenzene, C.I. 10355), a derivative of aniline, is widely used as an industrial antioxidant, dye mordant and reagent and is also employed in agriculture as a fungicide and antihelmintic. Diphenylamine can inhibits oxidative phosphorylationsignificantly, although its inhibition potency was weaker than that of NSAIDs with a diphenylamine structure.",205.68,"537-67-7",{"v":41,"d":"41.00"},199.34,{"v":1,"d":"1.00"},4.86,"http://www.selleckchem.com/products/diphenylamine-hydrochloride.html","C12H12ClN","Hydrochloride","N-Phenylbenzenamine, Anilinobenzene, C.I. 10355","Cl.N(C1=CC=CC=C1)C2=CC=CC=C2",3.762,0,1,2]
["S5605","Tos-Arg-OMe HCl","d9","L6200-14","in 10mM DMSO","Others","Others","Tos-Arg-OMe HCl, a kind of amino acid  derivatives, is a substrate for trypsin, plasmin, thrombin and orther proteases.",378.87,"1784-03-8",{"v":76,"d":"76.00"},200.59,{"v":-1,"d":"-1.00"},-2.64,"https://www.selleckchem.com/products/tos-arg-ome-hcl.html","C14H23ClN4O4S","free base","N/A","Cl.COC(=O)C(CCCNC(N)=N)N[S](=O)(=O)C1=CC=C(C)C=C1",1.131,4,3,10]
["S5616","4-Methylcatechol","e9","L6200-14","in 10mM DMSO","Others","Others","4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.",124.14,"452-86-8",{"v":24,"d":"24.00"},193.33,{"v":-1,"d":"-1.00"},-8.06,"https://www.selleckchem.com/products/4-methylcatechol.html","C7H8O2","free base","P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol","CC1=CC(=C(O)C=C1)O",1.832,0,2,0]
["S5623","Bedaquiline","f9","L6200-14","in 10mM DMSO","ATPase","Transmembrane Transporters","Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).",{"v":555.5,"d":"555.50"},"843663-66-1",{"v":12,"d":"12.00"},{"v":21.6,"d":"21.60"},"<1","N/A","https://www.selleckchem.com/products/bedaquiline.html","C32H31BrN2O2","free base","TMC-207, R207910","COC1=NC2=CC=C(Br)C=C2C=C1C(C3=CC=CC=C3)C(O)(CCN(C)C)C4=CC=CC5=CC=CC=C45",6.933,2,0,8]
["S5627","Amsacrine hydrochloride","g9","L6200-14","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.",429.92,"54301-15-4",{"v":85,"d":"85.00"},197.71,"N/A",{"v":0,"d":"0.00"},"https://www.selleckchem.com/products/amsacrine-hydrochloride.html","C21H20ClN3O3S","free base","m-AMSA, acridinyl anisidide","Cl.COC1=CC(=CC=C1NC2=C3C=CC=CC3=NC4=C2C=CC=C4)N[S](C)(=O)=O",{"v":4.18,"d":"4.180"},4,2,5]
["S5640","Ethyl caffeate","h9","L6200-14","in 10mM DMSO","COX,NF-κB,NOS,PGES","NF-κB","Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.",208.21,"102-37-4",{"v":41,"d":"41.00"},196.92,{"v":-1,"d":"-1.00"},{"v":-4.8,"d":"-4.80"},"https://www.selleckchem.com/products/ethyl-caffeate.html","C11H12O4","Ester","ETHYL 3, 4-DIHYDROXYCINNAMATE","CCOC(=O)/C=C/C1=CC(=C(O)C=C1)O",2.018,2,2,4]
["S5641","Rhodamine B","a10","L6200-14","in 10mM DMSO","Dyes","Others","Rhodamine B is used as a tracer dye in water to determine the rate and direction of flow and transport. It is a staining fluorescent dye used in fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy and ELISA in biotechnology fields.",479.01,"81-88-9",{"v":96,"d":"96.00"},200.41,{"v":-1,"d":"-1.00"},-2.09,"https://www.selleckchem.com/products/rhodamine-b.html","C28H31ClN2O3","xanthene dyes","N/A","[Cl-].CCN(CC)C1=CC2=C(C=C1)C(=C3C=CC(C=C3O2)=[N+](CC)CC)C4=C(C=CC=C4)C(O)=O",2.547,2,0,7]
["S5648","Iguratimod","b10","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Iguratimod (T-614) is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.",374.37,"123663-49-0",{"v":50,"d":"50.00"},133.56,"N/A","N/A","http://selleckchem.com/products/iguratimod.html","C17H14N2O6S","free base","T-614","C[S](=O)(=O)NC1=CC2=C(C=C1OC3=CC=CC=C3)C(=O)C(=CO2)NC=O",0.605,6,2,5]
["S5652","Elbasvir","c10","L6200-14","in 10mM DMSO","HCV Protease","Proteases","Elbasvir (MK8742) is an NS5A inhibitor, preventing hepatitis C viral RNA replication and virion assembly. Median EC50 values range from 0.2 to 3600 pmol/L, based on genotype.",882.02,"1370468-36-2",{"v":100,"d":"100.00"},113.38,"<1","N/A","http://selleckchem.com/products/elbasvir.html","C49H55N9O7","free base","MK8742","COC(=O)NC(C(C)C)C(=O)N1CCCC1C2=NC=C([NH]2)C3=CC4=C(C=C3)C5=CC6=C(C=CC(=C6)C7=CN=C([NH]7)C8CCCN8C(=O)C(NC(=O)OC)C(C)C)[N]5C(O4)C9=CC=CC=C9",7.424,9,4,13]
["S5658","Omeprazole Sodium","d10","L6200-14","in 10mM DMSO","P450 (e.g. CYP17),Proton Pump","Transmembrane Transporters","Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.",{"v":367.4,"d":"367.40"},"95510-70-6",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://www.selleckchem.com/products/omeprazole-sodium.html","C17H18N3NaO3S","Sodium Salt","N/A","COC1=CC2=C(C=C1)[N]([Na])C(=N2)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S5686","Tryptanthrin","e10","L6200-14","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.",248.24,"13220-57-0",{"v":8,"d":"8.00"},32.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tryptanthrin.html","C15H8N2O2","Free Base","N/A","O=C1N2C3=C(C=CC=C3)C(=O)C2=NC4=CC=CC=C14",2.331,3,0,0]
["S5688","Tropolone (NSC 89303)","f10","L6200-14","in 10mM DMSO","Others","Metabolism","Tropolone (NSC 89303, 2-Hydroxytropone, Purpurocatechol), a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion. It is able to inhibit ferric iron reduction by catecholates, lowering the redox potential of the iron couple.",122.12,"533-75-5",{"v":24,"d":"24.00"},196.53,"N/A","N/A","https://www.selleckchem.com/products/tropolone.html","C7H6O2","free base","2-Hydroxytropone, Purpurocatechol","OC1=CC=CC=CC1=O",0.741,1,1,0]
["S5696","JNJ0966","g10","L6200-14","in 10mM DMSO","MMP","Proteases","JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.",360.45,"315705-75-0",{"v":72,"d":"72.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/jnj0966.html","C16H16N4O2S2","Free Base","N/A","COC1=CC=CC=C1NC2=NC(=CS2)C3=C(C)N=C(NC(C)=O)S3",2.999,4,2,5]
["S5698","Ketorolac tromethamine salt","h10","L6200-14","in 10mM DMSO","COX","Immunology & Inflammation","Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.",{"v":376.4,"d":"376.40"},"74103-07-4",{"v":75,"d":"75.00"},199.26,{"v":75,"d":"75.00"},199.26,"http://www.selleckchem.com/products/ketorolac-tromethamine-salt.html","C19H24N2O6","tromethamine salt","N/A","NC(CO)(CO)CO.OC(=O)C1CC[N]2C1=CC=C2C(=O)C3=CC=CC=C3",-2.028,2,4,6]
["S5709","Norgestrel","a11","L6200-14","in 10mM DMSO","ROS","Immunology & Inflammation","Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.",312.45,"6533-00-2",{"v":62,"d":"62.00"},198.43,"<1","N/A","http://selleckchem.com/products/norgestrel.html","C21H28O2","free base","WY-3707, SH-70850, SH-850, FH 122-A","CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C",4.771,1,0,1]
["S5710","Ambroxol","b11","L6200-14","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.",{"v":378.1,"d":"378.10"},"18683-91-5",{"v":76,"d":"76.00"},{"v":201,"d":"201.00"},{"v":-1,"d":"-1.00"},-2.64,"https://www.selleckchem.com/products/ambroxol.html","C13H18Br2N2O","Expectorant","N/A","NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",2.739,0,3,3]
["S5711","Deracoxib","c11","L6200-14","in 10mM DMSO","COX","Immunology & Inflammation","Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).",397.37,"169590-41-4",{"v":80,"d":"80.00"},201.32,"<1","N/A","http://selleckchem.com/products/deracoxib.html","C17H14F3N3O3S","free base","SC-046","COC1=C(F)C=C(C=C1)C2=CC(=N[N]2C3=CC=C(C=C3)[S](N)(=O)=O)C(F)F",3.642,4,1,5]
["S5716","Abemaciclib (LY2835219)","d11","L6200-14","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.",506.59,"1231929-97-7",{"v":6,"d":"6.00"},11.84,"<1","N/A","http://selleckchem.com/products/abemaciclib.html","C27H32F2N8","free base","LY2835219","CCN1CCN(CC1)CC2=CN=C(NC3=NC=C(F)C(=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)C=C2",4.957,4,1,7]
["S5720","Glecaprevir","e11","L6200-14","in 10mM DMSO","HCV Protease","Proteases","Glecaprevir(ABT-493) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication.  It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.",838.87,"1365970-03-1",{"v":100,"d":"100.00"},119.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/glecaprevir.html","C38H46F4N6O9S","Free Base","ABT-493","CC(C)(C)C1NC(=O)OC2CCCC2OC\\C=C\\C(F)(F)C3=NC4=C(C=CC=C4)N=C3OC5CC(N(C5)C1=O)C(=O)NC6(CC6C(F)F)C(=O)N[S](=O)(=O)C7(C)CC7",3.746,11,3,7]
["S5742","Deferoxamine mesylate (Ba 33112)","f11","L6200-14","in 10mM DMSO","Autophagy,Beta Amyloid,Ferroptosis,HIF","Autophagy","Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.",656.79,"138-14-7",{"v":100,"d":"100.00"},152.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/deferoxamine-mesylate.html","C26H52N6O11S","mesylate","Desferrioxamine B, DFOM, NSC 644468","CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.C[S](O)(=O)=O",-1.304,5,3,23]
["S5752","Abametapir","g11","L6200-14","in 10mM DMSO","MMP","Proteases","Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.",184.24,"1762-34-1",{"v":37,"d":"37.00"},200.83,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/abametapir.html","C12H12N2","Free Base","HA-44, BRN 0123183","CC1=CN=C(C=C1)C2=CC=C(C)C=N2",2.876,2,0,1]
["S5754","Baricitinib phosphate","h11","L6200-14","in 10mM DMSO","COVID-19,JAK","JAK/STAT","Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.",469.41,"1187595-84-1",{"v":94,"d":"94.00"},200.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/baricitinib-phosphate.html","C16H20N7O6PS","phosphate","INCB-028050 phosphate, LY-3009104 phosphate","CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4.O[P](O)(O)=O",-0.108,5,1,5]
["S5759","Methyl linoleate","a2","L6200-15","in 10mM DMSO","Others","Others","Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes.",294.47,"112-63-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/methyl-linoleate.html","C19H34O2","Free Base","Linoleic acid methyl ester","CCCCC/C=C\\C\\C=C/CCCCCCCC(=O)OC",6.641,2,0,15]
["S5767","Aliskiren","b2","L6200-15","in 10mM DMSO","RAAS","Metabolism","Aliskiren(CGP 60536) is a renin inhibitor with antihypertensive activity.",551.76,"173334-57-1",{"v":100,"d":"100.00"},181.24,{"v":6,"d":"6.00"},10.87,"http://www.selleckchem.com/products/aliskiren.html","C30H53N3O6","Free Base","CGP 60536","COCCCOC1=C(OC)C=CC(=C1)CC(CC(N)C(O)CC(C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C",3.327,5,4,19]
["S5771","Sulforaphane","c2","L6200-15","in 10mM DMSO","HDAC,Heme Oxygenase,NF-κB,Nrf2,ROS","Immunology & Inflammation","Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.,",177.29,"4478-93-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/sulforaphane.html","C6H11NOS2","Free Base","N/A","C[S](=O)CCCCN=C=S",1.157,2,0,5]
["S5772","AS-8351","d2","L6200-15","in 10mM DMSO","Histone Demethylase","Epigenetics","AS-8351 is a histone demethylase inhibitor that could induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.",{"v":291.3,"d":"291.30"},"796-42-9",{"v":58,"d":"58.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/as-8351.html","C17H13N3O2","Free Base","N/A","OC1=CC=C2C=CC=CC2=C1/C=N/NC(=O)C3=CC=NC=C3",2.199,3,2,3]
["S5774","CY-09","e2","L6200-15","in 10mM DMSO","NLRP3","Immunology & Inflammation","CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself。 It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.",423.43,"1073612-91-5",{"v":85,"d":"85.00"},200.74,"<1","N/A","http://www.selleckchem.com/products/cy-09.html","C19H12F3NO3S2","Free Base","N/A","OC(=O)C1=CC=C(C=C1)/C=C2/SC(=S)N(CC3=CC(=CC=C3)C(F)(F)F)C2=O",5.202,2,0,5]
["S5787","Dronedarone","f2","L6200-15","in 10mM DMSO","Adrenergic Receptor","Transmembrane Transporters","Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).",556.76,"141626-36-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/dronedarone.html","C31H44N2O5S","Free Base","SR33589","CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=C2C=C(N[S](C)(=O)=O)C=C3",7.015,5,1,18]
["S5791","Cyclic Pifithrin-α hydrobromide","g2","L6200-15","in 10mM DMSO","p53","Apoptosis","Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.",349.29,"511296-88-1",{"v":27,"d":"27.00"},{"v":77.3,"d":"77.30"},{"v":1,"d":"1.00"},2.86,"http://www.selleckchem.com/products/cyclic-pifithrin-hydrobromide.html","C16H17BrN2S","hydrobromide","N/A","Br.CC1=CC=C(C=C1)C2=C[N]3C(=N2)SC4=C3CCCC4",4.616,1,0,1]
["S5804","N-Acetylcysteine amide","h2","L6200-15","in 10mM DMSO","HIF,Immunology & Inflammation related,NF-κB,ROS","Immunology & Inflammation","N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.",162.21,"38520-57-9",{"v":32,"d":"32.00"},197.28,{"v":32,"d":"32.00"},197.28,"http://www.selleckchem.com/products/n-acetylcysteine-amide.html","C5H10N2O2S","Free Base","N/A","CC(=O)NC(CS)C(N)=O",-1.205,2,2,3]
["S5810","UF010","a3","L6200-15","in 10mM DMSO","HDAC","Epigenetics","UF010 is a class I HDAC-selective inhibitor with IC50 values of 0.5 nM, 0.1 nM, 0.06 nM, 1.5 nM, 9.1 nM and 15.3 nM for HDAC1, HDAC2, HDAC3, HDAC8, HDAC6 and HDAC10, respectively.",271.15,"537672-41-6",{"v":54,"d":"54.00"},199.15,"<1","N/A","http://www.selleckchem.com/products/uf010.html","C11H15BrN2O","Free Base","N/A","CCCCNNC(=O)C1=CC=C(Br)C=C1",2.623,1,2,5]
["S5811","Kevetrin hydrochloride","b3","L6200-15","in 10mM DMSO","p53","Apoptosis","Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.",179.67,"66592-89-0",{"v":36,"d":"36.00"},200.37,{"v":36,"d":"36.00"},200.37,"http://www.selleckchem.com/products/kevetrin-hydrochloride.html","C5H10ClN3S","hydrochloride","Thioureidobutyronitrile HCl","Cl.NC(=N)SCCCC#N",1.105,0,1,4]
["S5812","Choline Fenofibrate","c3","L6200-15","in 10mM DMSO","PPAR","Metabolism","Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.",421.91,"856676-23-8",{"v":5,"d":"5.00"},11.85,{"v":9,"d":"9.00"},21.33,"http://www.selleckchem.com/products/choline-fenofibrate.html","C22H28ClNO5","Free Base","ABT-335","CC(C)(OC1=CC=C(C=C1)C(=O)C2=CC=C(Cl)C=C2)C([O-])=O.C[N+](C)(C)CCO",1.111,2,1,7]
["S5815","WAY-316606","d3","L6200-15","in 10mM DMSO","SFRP,Wnt/beta-catenin","Stem Cells & Wnt","WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.",448.48,"915759-45-4",{"v":90,"d":"90.00"},200.68,{"v":1,"d":"1.00"},2.23,"http://www.selleckchem.com/products/way-316606.html","C18H19F3N2O4S2","Free Base","N/A","FC(F)(F)C1=CC=C(C=C1[S](=O)(=O)NC2CCNCC2)[S](=O)(=O)C3=CC=CC=C3",{"v":2.36,"d":"2.360"},4,2,6]
["S5816","Pyrvinium","e3","L6200-15","in 10mM DMSO","Parasite","Microbiology","Pyrvinium is an anthelmintic effective for pinworms.",1151.39,"3546-41-6",{"v":22,"d":"22.00"},19.11,"<1","N/A","http://www.selleckchem.com/products/pyrvinium.html","C75H70N6O6","Free Base","N/A","CN(C)C1=CC2=CC=C(/C=C/C3=C(C)[N](C(=C3)C)C4=CC=CC=C4)[N+](=C2C=C1)C.CN(C)C5=CC6=CC=C(/C=C/C7=C(C)[N](C(=C7)C)C8=CC=CC=C8)[N+](=C6C=C5)C.OC9=C(CC%10=C(O)C(=CC%11=C%10C=CC=C%11)C([O-])=O)C%12=C(C=CC=C%12)C=C9C([O-])=O",13.931,0,2,12]
["S5817","GSK0660","f3","L6200-15","in 10mM DMSO","PPAR","Metabolism","GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (binding assay IC50 = 155 nM; antagonist assay IC50 = 300 nM) and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM.",418.49,"1014691-61-2",{"v":84,"d":"84.00"},200.72,{"v":1,"d":"1.00"},2.39,"http://www.selleckchem.com/products/gsk0660.html","C19H18N2O5S2","Free Base","N/A","COC(=O)C1=C(C=CS1)[S](=O)(=O)NC2=CC=C(NC3=CC=CC=C3)C=C2OC",{"v":3.66,"d":"3.660"},5,2,8]
["S5818","acalisib (GS-9820)","g3","L6200-15","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.",{"v":401.4,"d":"401.40"},"870281-34-8",{"v":80,"d":"80.00"},{"v":199.3,"d":"199.30"},{"v":1,"d":"1.00"},2.49,"http://www.selleckchem.com/products/acalisib-gs-9820.html","C21H16FN7O","Free Base","CAL-120","CC(NC1=NC=NC2=C1[NH]C=N2)C3=NC4=C(C=C(F)C=C4)C(=O)N3C5=CC=CC=C5",3.097,5,2,4]
["S5824","Cinnamyl alcohol","h3","L6200-15","in 10mM DMSO","PPAR","Metabolism","Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Cinnamyl alcohol can be significantly attenuated the enhanced expression of obesity-related proteins PPARγ in MDI medium-cultivated 3T3-L1 cells.",134.18,"104-54-1",{"v":27,"d":"27.00"},201.22,{"v":7,"d":"7.00"},52.17,"http://www.selleckchem.com/products/cinnamyl-alcohol.html","C9H10O","Free Base","N/A","OC/C=C/C1=CC=CC=C1",1.693,0,1,2]
["S5832","Pyrrole-2-carboxylic acid","a4","L6200-15","in 10mM DMSO","Others","Others","Pyrrole-2-carboxylic acid (2-Pyrrolecarboxylic acid) is a degradation product of sialic acids and a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase.",{"v":111.1,"d":"111.10"},"634-97-9",{"v":22,"d":"22.00"},198.02,{"v":1,"d":"1.00"},{"v":9,"d":"9.00"},"http://www.selleckchem.com/products/pyrrole-2-carboxylic-acid.html","C5H5NO2","Free Base","2-Pyrrolecarboxylic acid","OC(=O)C1=CC=C[NH]1",0.844,1,1,1]
["S5834","p-Coumaric acid ethyl ester","b4","L6200-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties.",192.21,"7362-39-2",{"v":38,"d":"38.00"},{"v":197.7,"d":"197.70"},{"v":1,"d":"1.00"},{"v":5.2,"d":"5.20"},"http://www.selleckchem.com/products/p-coumaric-acid-ethyl-ester.html","C11H12O3","ethyl ester","N/A","CCOC(=O)\\C=C\\C1=CC=C(O)C=C1",{"v":2.26,"d":"2.260"},2,1,4]
["S5840","Palifosfamide","c4","L6200-15","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.",221.02,"31645-39-3",{"v":44,"d":"44.00"},199.08,{"v":13,"d":"13.00"},58.82,"http://www.selleckchem.com/products/palifosfamide.html","C4H11Cl2N2O2P","Free Base","ZIO-201, Isophosphamide mustard","O[P](=O)(NCCCl)NCCCl",0.018,1,2,6]
["S5841","DKM 2-93","d4","L6200-15","in 10mM DMSO","E1 Activating","Ubiquitin","DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5).",243.69,"65836-72-8",{"v":49,"d":"49.00"},201.08,{"v":1,"d":"1.00"},{"v":4.1,"d":"4.10"},"http://www.selleckchem.com/products/dkm2-93.html","C11H14ClNO3","Free Base","N/A","COC1=CC=C(CNC(=O)CCl)C=C1OC",1.457,3,1,5]
["S5842","Cabergoline","e4","L6200-15","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.",{"v":451.6,"d":"451.60"},"81409-90-7",{"v":90,"d":"90.00"},199.29,{"v":1,"d":"1.00"},2.21,"http://www.selleckchem.com/products/cabergoline.html","C26H37N5O2","Free Base","FCE-21336","CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=C[NH]C4=C3C2=CC=C4)N(CC=C)C1",3.036,2,2,8]
["S5903","JANEX-1","f4","L6200-15","in 10mM DMSO","JAK","JAK/STAT","JANEX-1 (WHI-P131) is a small molecule inhibitor of JAK3 that selectively inhibits JAK3 at an IC50 of 78 µM without altering the activity of JAK1 or JAK2, or any other protein tyrosine kinases (IC50 ≥ 350 µM).",297.31,"202475-60-3",{"v":5,"d":"5.00"},16.82,"<1","N/A","http://www.selleckchem.com/products/janex-1.html","C16H15N3O3","Free Base","WHI-P131","COC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=C(O)C=C3",3.202,4,2,4]
["S5904","WHI-P97","g4","L6200-15","in 10mM DMSO","JAK","JAK/STAT","WHI-P97 is a potent inhibitor of JAK-3 with an estimated Ki value of 0.09 μM in modeling studies and a measured IC50 value of 2.5 μM in EGFR kinase inhibition assays.",{"v":455.1,"d":"455.10"},"211555-05-4",{"v":8,"d":"8.00"},17.58,"<1","N/A","http://www.selleckchem.com/products/whi-p97.html","C16H13Br2N3O3","Free Base","N/A","COC1=CC2=NC=NC(=C2C=C1OC)NC3=CC(=C(O)C(=C3)Br)Br",4.699,4,2,4]
["S5905","Suberohydroxamic acid","h4","L6200-15","in 10mM DMSO","HDAC","Epigenetics","Suberohydroxamic acid (suberic bishydroxamic acid) is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.",204.22,"38937-66-5",{"v":41,"d":"41.00"},200.76,{"v":4,"d":"4.00"},19.59,"http://www.selleckchem.com/products/suberohydroxamic-acid.html","C8H16N2O4","Free Base","suberic bishydroxamic acid","ONC(=O)CCCCCCC(=O)NO",0.235,2,2,7]
["S5909","Anagliptin","a5","L6200-15","in 10mM DMSO","DPP","Proteases","Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.",383.45,"739366-20-2",{"v":77,"d":"77.00"},200.81,{"v":20,"d":"20.00"},52.16,"http://www.selleckchem.com/products/anagliptin.html","C19H25N7O2","Free Base","N/A","CC1=N[N]2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCCC3C#N",-0.629,4,2,6]
["S5913","Cambinol","b5","L6200-15","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).",360.43,"14513-15-6",{"v":21,"d":"21.00"},58.26,"<1","N/A","http://www.selleckchem.com/products/cambinol.html","C21H16N2O2S","Free Base","N/A","OC1=C(CC2=C(NC(=S)NC2=O)C3=CC=CC=C3)C4=CC=CC=C4C=C1",4.431,1,3,3]
["S5914","AK 7","c5","L6200-15","in 10mM DMSO","Sirtuin","Epigenetics","AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.",437.35,"420831-40-9",{"v":87,"d":"87.00"},198.93,"<1","N/A","http://www.selleckchem.com/products/ak-7.html","C19H21BrN2O3S","Free Base","N/A","BrC1=CC(=CC=C1)NC(=O)C2=CC=CC(=C2)[S](=O)(=O)N3CCCCCC3",3.853,3,1,4]
["S5915","OAC2","d5","L6200-15","in 10mM DMSO","OCT","Transmembrane Transporters","OAC-2 is an Octamer-binding transcription factor 4 (OCT4) activator, enhancing iPSC reprogramming efficiency.",236.27,"6019-39-2",{"v":47,"d":"47.00"},198.92,"<1","N/A","http://www.selleckchem.com/products/oac2.html","C15H12N2O","Free Base","N/A","O=C(NC1=CC2=C([NH]C=C2)C=C1)C3=CC=CC=C3",2.908,1,2,2]
["S5916","GSK 5959","e5","L6200-15","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.",394.47,"901245-65-6",{"v":6,"d":"6.00"},15.21,"<1","N/A","http://www.selleckchem.com/products/gsk-5959.html","C22H26N4O3","Free Base","N/A","COC1=CC=CC=C1C(=O)NC2=C(C=C3N(C)C(=O)N(C)C3=C2)N4CCCCC4",2.952,3,1,4]
["S5917","Solcitinib","f5","L6200-15","in 10mM DMSO","JAK","JAK/STAT","Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.",389.45,"1206163-45-2",{"v":30,"d":"30.00"},77.03,"<1","N/A","http://www.selleckchem.com/products/solcitinib.html","C22H23N5O2","Free Base","GLPG0778, GSK2586184","CC1(C)CN(C1)C(=O)C2=CC=C(C=C2)C3=CC=CC4=NC(=N[N]34)NC(=O)C5CC5",3.118,4,1,4]
["S5918","CAY10602","g5","L6200-15","in 10mM DMSO","Sirtuin","Epigenetics","CAY10602 is a potent SIRT1 activator.",418.44,"374922-43-7",{"v":56,"d":"56.00"},133.83,"<1","N/A","http://www.selleckchem.com/products/cay10602.html","C22H15FN4O2S","Free Base","N/A","NC1=C(C2=C(N=C3C=CC=CC3=N2)[N]1C4=CC=C(F)C=C4)[S](=O)(=O)C5=CC=CC=C5",4.683,4,1,3]
["S5920","CA-5f","h5","L6200-15","in 10mM DMSO","Autophagy","Autophagy","CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.",388.46,"1370032-19-1",{"v":78,"d":"78.00"},200.79,{"v":1,"d":"1.00"},2.57,"http://www.selleckchem.com/products/ca-5f.html","C24H24N2O3","Free Base","N/A","COC1=CC=C(\\C=C2/CN(C)C\\C(=C/C3=C[NH]C4=C3C=CC=C4)C2=O)C=C1OC",4.168,3,1,4]
["S5927","Proguanil","a6","L6200-15","in 10mM DMSO","Anti-infection,DHFR","Microbiology","Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.",253.73,"500-92-5",{"v":51,"d":"51.00"},{"v":201,"d":"201.00"},{"v":1,"d":"1.00"},3.94,"http://www.selleckchem.com/products/proguanil.html","C11H16ClN5","Free Base","chlorguanide, chloroguanide","CC(C)NC(=N)NC(=N)NC1=CC=C(Cl)C=C1",2.226,0,3,6]
["S5928","Zerumbone","b6","L6200-15","in 10mM DMSO","Others","Others","Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities.",218.33,"471-05-6",{"v":44,"d":"44.00"},201.53,{"v":1,"d":"1.00"},4.58,"http://www.selleckchem.com/products/zerumbone.html","C15H22O","Free Base","N/A","CC\\1=C/CC(C)(C)\\C=C\\C(=O)\\C(=C\\CC1)C",4.455,1,0,0]
["S5929","4-Octyl Itaconate","c6","L6200-15","in 10mM DMSO","Nrf2","Immunology & Inflammation","4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.",242.31,"3133-16-2",{"v":48,"d":"48.00"},198.09,{"v":1,"d":"1.00"},4.13,"http://www.selleckchem.com/products/4-octyl-Itaconate.html","C13H22O4","Free Base","N/A","CCCCCCCCOC(=O)CC(=C)C(O)=O",3.497,3,0,11]
["S5933","K 858","d6","L6200-15","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily.",277.34,"72926-24-0",{"v":55,"d":"55.00"},198.31,{"v":1,"d":"1.00"},3.61,"http://www.selleckchem.com/products/k858.html","C13H15N3O2S","Free Base","N/A","CC(=O)NC1=NN(C(C)=O)C(C)(S1)C2=CC=CC=C2",1.535,3,1,2]
["S5950","Fingolimod","e6","L6200-15","in 10mM DMSO","S1P Receptor","Neuronal Signaling","Fingolimod (FTY-720A, FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis.",307.47,"162359-55-9",{"v":13,"d":"13.00"},42.28,{"v":1,"d":"1.00"},3.25,"https://www.selleckchem.com/products/fingolimod.html","C19H33NO2","Free Base","FTY-720A, FTY-720","CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1",4.198,0,3,12]
["S6002","Disufenton sodium","f6","L6200-15","in 10mM DMSO","Others","Others","Disufenton Sodium (NXY-059, Cerovive) is a novel nitrone, shows efficacious neuroprotective effects. Phase 3.",381.33,"168021-79-2",{"v":76,"d":"76.00"},{"v":199.3,"d":"199.30"},{"v":76,"d":"76.00"},{"v":199.3,"d":"199.30"},"http://selleckchem.com/products/NXY-059.html","C11H13NNa2O7S2","Disodium salt","NXY-059, Cerovive","[Na+].[Na+].CC(C)(C)/[N+]([O-])=C/C1=CC=C(C=C1[S]([O-])(=O)=O)[S]([O-])(=O)=O",-3.972,0,0,4]
["S6005","VX-702","g6","L6200-15","in 10mM DMSO","p38 MAPK","MAPK","VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.",{"v":404.3,"d":"404.30"},"745833-23-2",{"v":81,"d":"81.00"},200.35,"<1","N/A","http://selleckchem.com/products/VX-702.html","C19H12F4N4O2","free base","N/A","NC(=O)N(C1=NC(=C(C=C1)C(N)=O)C2=C(F)C=C(F)C=C2)C3=C(F)C=CC=C3F",3.682,3,2,4]
["S6018","2,3,4-Trihydroxybenzoic acid","h6","L6200-15","in 10mM DMSO","Others","Others","2,3,4-Trihydroxybenzoic acid is a phenol constituent of Pachysandra terminalis with antioxidant activity.",170.12,"610-02-6",{"v":34,"d":"34.00"},199.86,"N/A","N/A","http://www.selleck.cn/products/2-3-4-trihydroxybenzoic-acid.html","C7H6O5","free base","N/A","OC(=O)C1=C(O)C(=C(O)C=C1)O",0.733,1,3,1]
["S6073","Diclofenac acid","a7","L6200-15","in 10mM DMSO","COX,Immunology & Inflammation related","Immunology & Inflammation","Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.",296.15,"15307-86-5",{"v":59,"d":"59.00"},199.22,"N/A","N/A","http://www.selleck.cn/products/diclofenac-acid.html","C14H11Cl2NO2","free base","N/A","OC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1",4.373,1,1,4]
["S6088","6-(Dimethylamino)purine","b7","L6200-15","in 10mM DMSO","Serine/threonin kinase","Apoptosis","6-Dimethylaminopurine (N,N-Dimethyladenine) is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes.",163.18,"938-55-6",{"v":32,"d":"32.00"},{"v":196.1,"d":"196.10"},"N/A","N/A","http://www.selleck.cn/products/6-dimethylamino-purine.html","C7H9N5","free base","N,N-Dimethyladenine","CN(C)C1=NC=NC2=C1[NH]C=N2",0.463,3,1,1]
["S6104","(±)-α-Tocopherol","c7","L6200-15","in 10mM DMSO","Vitamin","Metabolism","(±)-α-Tocopherol is a biologically active form of vitamin E, which is a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.",430.71,"10191-41-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/tocopherol.html","C29H50O2","free base","N/A","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(=C(C)C(=C2O1)C)O",{"v":10.44,"d":"10.440"},1,1,12]
["S6111","L-Hydroorotic acid","d7","L6200-15","in 10mM DMSO","Others","Others","L-Dihydroorotic acid (L-dihydroorotate) is an intermediate in the metabolism of Pyrimidine. It is a substrate for Dihydroorotate dehydrogenase (mitochondrial).",158.11,"5988-19-2",{"v":31,"d":"31.00"},196.07,"N/A","N/A","http://www.selleck.cn/products/l-hydroorotic-acid.html","C5H6N2O4","free base","L-dihydroorotate","OC(=O)C1CC(=O)NC(=O)N1",-1.296,3,2,1]
["S6125","Glycerol trilinoleate","e7","L6200-15","in 10mM DMSO","Others","Others","Glycerol trilinoleate (Trilinolein) is a triacylglycerol and has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. It is also an antioxidant.",879.38,"537-40-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/glycerol-trilinoleate.html","C57H98O6","free base","Trilinolein","CCCCC/C=C\\C\\C=C/CCCCCCCC(=O)OCC(COC(=O)CCCCCCC\\C=C/C/C=C\\CCCCC)OC(=O)CCCCCCC\\C=C/C/C=C\\CCCCC",19.591,6,0,50]
["S6146","Glycoursodeoxycholic acid","f7","L6200-15","in 10mM DMSO","Others","Others","Glycoursodeoxycholic acid (Ursodeoxycholyl Glycine, Glycine ursodeoxycholic acid) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment.",449.62,"64480-66-6",{"v":89,"d":"89.00"},197.95,"N/A","N/A","http://www.selleck.cn/products/glycoursodeoxycholic-acid.html","C26H43NO5","free base","Ursodeoxycholyl Glycine, Glycine ursodeoxycholic acid","CC(CCC(=O)NCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",3.074,2,3,6]
["S6182","L-Gulono-1,4-lactone","g7","L6200-15","in 10mM DMSO","Others","Others","L-Gulono-1,4-lactone (L-Gulonolactone, L-Gulono-gamma-lactone, reduced ascorbic acid) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals.",178.14,"1128-23-0",35.63,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/l-gulono-1-4-lactone.html","C6H10O6","free base","L-Gulonolactone, L-Gulono-gamma-lactone, reduced ascorbic acid","OCC(O)C1OC(=O)C(O)C1O",-2.229,2,4,2]
["S6202","Butylated hydroxytoluene","h7","L6200-15","in 10mM DMSO","Others","Others","Butylated hydroxytoluene (dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT) is a lipophilic organic compound that is useful for its antioxidant properties.",220.35,"128-37-0",44.07,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/butylated-hydroxytoluene.html","C15H24O","free base","dibutylhydroxytoluene, Dibutylated hydroxytoluene, AO-29, BHT","CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C",4.875,0,1,2]
["S6221","Methyl cinnamate","a8","L6200-15","in 10mM DMSO","AMPK,CaMK,Tyrosinase","Proteases","Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.",162.19,"103-26-4",32.44,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/methyl-cinnamate.html","C10H10O2","free base","N/A","COC(=O)/C=C/C1=CC=CC=C1",2.153,2,0,3]
["S6229","Lauryl gallate","b8","L6200-15","in 10mM DMSO","Others","Others","Lauryl gallate (Dodecyl gallate) is the ester of dodecanol and gallic acid that exhibits both potent chain-breaking and preventive antioxidant activity.",338.44,"1166-52-5",67.69,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/lauryl-gallate.html","C19H30O5","free base","Dodecyl gallate","CCCCCCCCCCCCOC(=O)C1=CC(=C(O)C(=C1)O)O",5.937,2,3,13]
["S6254","Hydrocinnamic acid","c8","L6200-15","in 10mM DMSO","Fungal","Microbiology","Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite.",150.17,"501-52-0",30.03,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/hydrocinnamic-acid.html","C9H10O2","free base","3-phenylpropionic acid, Benzylacetic acid","OC(=O)CCC1=CC=CC=C1",{"v":1.95,"d":"1.950"},1,0,3]
["S6256","Isocytosine","d8","L6200-15","in 10mM DMSO","Others","Others","Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases.",{"v":111.1,"d":"111.10"},"108-53-2",11.11,100.01,"N/A","N/A","http://www.selleck.cn/products/isocytosine.html","C4H5N3O","free base","2-aminouracil","NC1=NC=CC(=O)N1",-0.958,2,2,0]
["S6338","3,4-Dihydroxyhydrocinnamic acid","e8","L6200-15","in 10mM DMSO","Others","Others","3,4-Dihydroxyhydrocinnamic acid (Dihydrocaffeic acid) is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties.",182.17,"1078-61-1",36.43,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/3-4-dihydroxyhydrocinnamic-acid.html","C9H10O4","free base","Dihydrocaffeic acid","OC(=O)CCC1=CC(=C(O)C=C1)O",1.466,1,2,3]
["S6348","(+)-Delta-Tocopherol","f8","L6200-15","in 10mM DMSO","Others","Others","(+)-Delta-Tocopherol (8-Methyltocol) is the orally bioavailable delta form of the naturally-occurring fat-soluble vitamin E, mostly found in soybean and corn oils, with potential antioxidant activity.",402.65,"119-13-1",80.53,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/delta-tocopherol.html","C27H46O2","free base","8-Methyltocol","CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(O1)C(=CC(=C2)O)C",9.468,1,1,12]
["S6400","Glucosamine","g8","L6200-15","in 10mM DMSO","HIF","Angiogenesis","Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.",179.17,"3416-24-8",{"v":23,"d":"23.00"},128.37,{"v":36,"d":"36.00"},200.93,"http://www.selleck.cn/products/glucosamine.html","C6H13NO5","Free Base","2-amino-2-deoxy-D-glucose","NC(C=O)C(O)C(O)C(O)CO",-3.081,1,5,5]
["S6402","2-Aminoethanethiol","h8","L6200-15","in 10mM DMSO","Others","Others","2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.",77.15,"60-23-1",{"v":15,"d":"15.00"},194.43,{"v":15,"d":"15.00"},194.43,"http://www.selleck.cn/products/2-aminoethanethiol.html","C2H7NS","Free Base","cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine","NCCS",-0.216,0,1,1]
["S6414","Apilimod (STA-5326)","a9","L6200-15","in 10mM DMSO","Interleukins,PIKfyve","PI3K/Akt/mTOR","Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.",418.49,"541550-19-0",{"v":84,"d":"84.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/apilimod.html","C23H26N6O2","Free Base","STA-5326","CC1=CC=CC(=C1)\\C=N\\NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4",4.485,6,1,8]
["S6420","AGI 1067","b9","L6200-15","in 10mM DMSO","Others","Immunology & Inflammation","AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.",616.91,"216167-82-7",{"v":100,"d":"100.00"},{"v":162.1,"d":"162.10"},"<1","N/A","http://www.selleck.cn/products/agi-1067.html","C35H52O5S2","Free Base","N/A","CC(C)(C)C1=C(O)C(=CC(=C1)SC(C)(C)SC2=CC(=C(OC(=O)CCC(O)=O)C(=C2)C(C)(C)C)C(C)(C)C)C(C)(C)C",9.634,3,1,13]
["S6422","Lazabemide","c9","L6200-15","in 10mM DMSO","MAO","Metabolism","Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.",{"v":236.1,"d":"236.10"},"103878-83-7",{"v":40,"d":"40.00"},169.42,{"v":40,"d":"40.00"},169.42,"http://www.selleck.cn/products/lazabemide.html","C8H11Cl2N3O","Free Base","Ro 19-6327","Cl.NCCNC(=O)C1=CC=C(Cl)C=N1",0.533,2,2,3]
["S6426","Hesperidin methylchalcone","d9","L6200-15","in 10mM DMSO","Others","Others","Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity.",624.59,"24292-52-2",{"v":100,"d":"100.00"},160.11,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/hesperidin-methylchalcone.html","C29H36O15","Free Base","N/A","COC1=C(O)C=C(/C=C/C(=O)C2=C(OC)C=C(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)C=C2O)C=C1",0.154,7,8,10]
["S6441","Riboflavin Tetrabutyrate","e9","L6200-15","in 10mM DMSO","Others","Others","Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.",656.72,"752-56-7",{"v":100,"d":"100.00"},152.27,"<1","N/A","http://www.selleck.cn/products/riboflavin-tetrabutyrate.html","C33H44N4O10","Tetrabutyrate","N/A","CCCC(=O)OCC(OC(=O)CCC)C(OC(=O)CCC)C(CN1C2=C(C=C(C)C(=C2)C)N=C3C(=O)NC(=O)N=C13)OC(=O)CCC",5.754,12,1,21]
["S6453","Bicyclol","f9","L6200-15","in 10mM DMSO","HBV","Microbiology","Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.",390.34,"118159-48-1",{"v":78,"d":"78.00"},199.83,"<1","N/A","http://www.selleck.cn/products/bicyclol.html","C19H18O9","Free Base","SY-801","COC(=O)C1=CC(=C2OCOC2=C1C3=C4OCOC4=C(OC)C=C3CO)OC",2.102,8,1,6]
["S6457","Flurbiprofen Axetil","g9","L6200-15","in 10mM DMSO","COX","Immunology & Inflammation","Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase.",330.35,"91503-79-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/flurbiprofen-axetil.html","C19H19FO4","Free Base","N/A","CC(OC(C)=O)OC(=O)C(C)C1=CC=C(C(=C1)F)C2=CC=CC=C2",3.906,4,0,7]
["S6472","Tinoridine hydrochloride","h9","L6200-15","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tinoridine hydrochloride (Y-3642) is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity.",352.88,"25913-34-2",{"v":18,"d":"18.00"},51.01,"<1","N/A","http://www.selleck.cn/products/tinoridine-hydrochloride.html","C17H21ClN2O2S","hydrochloride","Y-3642 HCl","Cl.CCOC(=O)C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2",3.265,2,1,5]
["S6494","CCCP","a10","L6200-15","in 10mM DMSO","IFN,STING","Immunology & Inflammation","CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, can inhibits STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP).",204.62,"555-60-2",{"v":41,"d":"41.00"},200.37,"<1","N/A","http://www.selleck.cn/products/cccp.html","C9H5ClN4","free base","Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone","ClC1=CC=CC(=C1)NN=C(C#N)C#N",2.469,1,1,2]
["S6495","6-Bromo-2-hydroxy-3-methoxybenzaldehyde","b10","L6200-15","in 10mM DMSO","IRE1","ER stress & UPR","6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.",231.04,"20035-41-0",{"v":46,"d":"46.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://www.selleck.cn/products/6-bromo-2-hydroxy-3-methoxybenzaldehyde.html","C8H7BrO3","free base","N/A","COC1=CC=C(Br)C(=C1O)C=O",2.079,2,1,2]
["S6497","SMI-16a","c10","L6200-15","in 10mM DMSO","Pim","Epigenetics","SMI-16a is a selective Pim kinase inhibitor with IC50 values of 150 nM and 20 nM for Pim1 and Pim2 respectively.",263.31,"587852-28-6",{"v":53,"d":"53.00"},201.28,"<1","N/A","http://www.selleck.cn/products/smi-16a.html","C13H13NO3S","free base","N/A","CCCOC1=CC=C(C=C1)\\C=C2\\SC(=O)NC2=O",2.798,3,1,4]
["S6498","T56-LIMKi","d10","L6200-15","in 10mM DMSO","LIM kinase","Cell Cycle","T56-LIMKi is a selective inhibitor of LIMK2.",389.33,"924473-59-6",{"v":78,"d":"78.00"},200.34,"<1","N/A","http://www.selleck.cn/products/t56-limki.html","C19H14F3N3O3","free base","N/A","CC1=NOC(=C1)C(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC(=C3)C(F)(F)F",3.369,4,2,5]
["S6503","LX2343","e10","L6200-15","in 10mM DMSO","BACE","Neuronal Signaling","LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.",474.91,"333745-53-2",{"v":95,"d":"95.00"},200.04,"<1","N/A","http://www.selleck.cn/products/lx2343.html","C22H19ClN2O6S","free base","N/A","COC1=CC=C(Cl)C=C1N(CC(=O)NC2=CC=C3OCOC3=C2)[S](=O)(=O)C4=CC=CC=C4",3.576,6,1,7]
["S6506","Compound 401","f10","L6200-15","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","Compound 401 is a synthetic inhibitor of DNA-PK(IC50=0.28 μM) and mTOR (IC50=5.3 μM). It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.",281.31,"168425-64-7",{"v":7,"d":"7.00"},24.88,"<1","N/A","http://www.selleck.cn/products/compound-401.html","C16H15N3O2","free base","N/A","O=C1C=C(N=C2N1C=CC3=C2C=CC=C3)N4CCOCC4",1.247,3,0,1]
["S6509","AG 494","g10","L6200-15","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).",280.28,"133550-35-3",{"v":56,"d":"56.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/ag-494.html","C16H12N2O3","free base","N/A","OC1=C(O)C=C(C=C1)\\C=C(C#N)\\C(=O)NC2=CC=CC=C2",2.437,1,3,3]
["S6516","GNE-477","h10","L6200-15","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR.",504.63,"1032754-81-6",{"v":25,"d":"25.00"},49.54,"<1","N/A","http://www.selleck.cn/products/gne-477.html","C21H28N8O3S2","free base","N/A","CC1=C(CN2CCN(CC2)[S](C)(=O)=O)SC3=C(N=C(N=C13)C4=CN=C(N)N=C4)N5CCOCC5",0.991,7,1,5]
["S6521","WHI-P258","a11","L6200-15","in 10mM DMSO","JAK","JAK/STAT","WHI-P258 is an inhibitor of JAK3 with Ki value of 72 μM.",281.31,"21561-09-1",{"v":14,"d":"14.00"},49.77,"<1","N/A","http://www.selleck.cn/products/whi-p258.html","C16H15N3O2","free base","N/A","COC1=CC2=C(C=C1OC)C(=NC=N2)NC3=CC=CC=C3",3.444,4,1,4]
["S6524","NSC 42834","b11","L6200-15","in 10mM DMSO","JAK","JAK/STAT","NSC42834 (JAK2 Inhibitor V, Z3) is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM.",344.45,"195371-52-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A",{"v":0,"d":"0.00"},"http://www.selleck.cn/products/nsc-42834.html","C23H24N2O","free base","JAK2 Inhibitor V, Z3","CC(CCC1=NC=CC=C1)(CCC2=NC=CC=C2)C(=O)C3=CC=CC=C3",4.718,3,0,8]
["S6533","Briciclib","c11","L6200-15","in 10mM DMSO","eIF","ER stress & UPR","Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).",474.42,"865783-99-9",{"v":95,"d":"95.00"},200.24,"<1","N/A","http://www.selleck.cn/products/briciclib.html","C19H23O10PS","free base","ON-014185","COC1=CC(=C(/C=C/[S](=O)(=O)CC2=CC=C(OC)C(=C2)O[P](O)(O)=O)C(=C1)OC)OC",2.319,7,0,10]
["S6536","TTP 22","d11","L6200-15","in 10mM DMSO","Casein Kinase","Metabolism","TTP22 is a casein kinase 2 (CK2) inhibitor with an IC50 value of 100 nM. It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.",330.42,"329907-28-0",{"v":66,"d":"66.00"},199.75,"<1","N/A","http://www.selleck.cn/products/ttp-22.html","C16H14N2O2S2","free base","N/A","CC1=CC=C(C=C1)C2=CSC3=C2C(=NC=N3)SCCC(O)=O",3.927,3,0,5]
["S6537","CVT-313","e11","L6200-15","in 10mM DMSO","CDK","Autophagy","CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases.",400.47,"199986-75-9",{"v":80,"d":"80.00"},199.77,"<1","N/A","http://www.selleck.cn/products/cvt-313.html","C20H28N6O3","free base","N/A","COC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3C(C)C)N(CCO)CCO)C=C1",2.217,4,3,10]
["S6541","MTX-211","f11","L6200-15","in 10mM DMSO","EGFR,PI3K","Protein Tyrosine Kinase","MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase.",478.33,"1952236-05-3",{"v":24,"d":"24.00"},50.17,"<1","N/A","http://www.selleck.cn/products/mtx-211.html","C20H14Cl2FN5O2S","free base","N/A","C[S](=O)(=O)NC1=CC(=CN=C1Cl)C2=CC3=C(NC4=CC=C(F)C(=C4)Cl)N=CN=C3C=C2",4.499,5,2,5]
["S6544","SR-3029","g11","L6200-15","in 10mM DMSO","Casein Kinase","Metabolism","SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively.",480.45,"1454585-06-8",{"v":47,"d":"47.00"},97.82,"<1","N/A","http://www.selleck.cn/products/sr-3029.html","C23H19F3N8O","free base","N/A","FC1=CC(=CC=C1)[N]2C=NC3=C2N=C(N=C3NCC4=NC5=C(F)C(=CC=C5[NH]4)F)N6CCOCC6",4.175,5,2,5]
["S6565","JK184","h11","L6200-15","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","JK184 inhibits Gli in the Hedgehog (Hh) pathway with IC50 of 30 nM in mammalian cells.",350.44,"315703-52-7",{"v":70,"d":"70.00"},199.75,"<1","N/A","http://www.selleck.cn/products/jk184.html","C19H18N4OS","free base","N/A","CCOC1=CC=C(NC2=NC(=CS2)C3=C(C)N=C4C=CC=C[N]34)C=C1",4.108,3,1,5]
["S6571","BQR695","a2","L6200-16","in 10mM DMSO","PI4K","PI3K/Akt/mTOR","BQR695 (NVP-BQR695) is a quinoxaline that displays sub-micromolar potency against human PI4KIIIβ (IC50~90 nM).",352.39,"1513879-21-4",{"v":70,"d":"70.00"},198.64,"<1","N/A","http://www.selleck.cn/products/bqr695.html","C19H20N4O3","free base","NVP-BQR695","CNC(=O)CNC1=CN=C2C=CC(=CC2=N1)C3=CC=C(OC)C(=C3)OC",2.187,5,2,6]
["S6574","KDU691","b2","L6200-16","in 10mM DMSO","PI4K","PI3K/Akt/mTOR","KDU691 is a Plasmodium PI4K-specific inhibitor with IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively.",419.86,"1513879-19-0",{"v":84,"d":"84.00"},200.07,"<1","N/A","http://www.selleck.cn/products/kdu691.html","C22H18ClN5O2","free base","N/A","CNC(=O)C1=CC=C(C=C1)C2=CN=C3C=NC(=C[N]23)C(=O)N(C)C4=CC=C(Cl)C=C4",2.658,4,1,4]
["S6577","PKC-theta inhibitor","c2","L6200-16","in 10mM DMSO","PKC","Cytoskeletal Signaling","PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.",454.45,"736048-65-0",{"v":91,"d":"91.00"},200.24,"<1","N/A","http://www.selleck.cn/products/pkc-theta-inhibitor.html","C20H25F3N6O3","free base","N/A","NCC1CCC(CC1)CNC2=NC(=NC=C2[N+]([O-])=O)NCC3=CC=CC=C3OC(F)(F)F",5.319,3,3,10]
["S6578","Longdaysin","d2","L6200-16","in 10mM DMSO","Casein Kinase","Metabolism","Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.",335.33,"1353867-91-0",{"v":67,"d":"67.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleck.cn/products/longdaysin.html","C16H16F3N5","free base","N/A","CC(C)[N]1C=NC2=C1N=CN=C2NCC3=CC=CC(=C3)C(F)(F)F",3.571,3,1,5]
["S7009","LCL161","e2","L6200-16","in 10mM DMSO","IAP,Mitochondrial Metabolism","Apoptosis","LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).",500.63,"1005342-46-0",{"v":100,"d":"100.00"},199.75,"<1","N/A","http://selleckchem.com/products/lcl161.html","C26H33FN4O3S","free base","N/A","CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(F)C=C4",3.785,4,2,8]
["S7016","VS-5584 (SB2343)","f2","L6200-16","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.",354.41,"1246560-33-7",{"v":71,"d":"71.00"},200.33,"<1","N/A","http://selleckchem.com/products/vs-5584-sb2343.html","C17H22N8O","free base","N/A","CC(C)[N]1C(=NC2=C1N=C(N=C2C3=CN=C(N)N=C3)N4CCOCC4)C",1.272,6,1,3]
["S7018","CZC24832","g2","L6200-16","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.",{"v":364.4,"d":"364.40"},"1159824-67-5",{"v":5,"d":"5.00"},13.72,"<1","N/A","http://selleckchem.com/products/czc24832.html","C15H17FN6O2S","free base","N/A","CC(C)(C)N[S](=O)(=O)C1=CN=CC(=C1)C2=C[N]3N=C(N)N=C3C(=C2)F",0.815,5,2,4]
["S7024","Stattic","h2","L6200-16","in 10mM DMSO","Apoptosis related,STAT","JAK/STAT","Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.",211.19,"19983-44-9",{"v":42,"d":"42.00"},198.87,"<1","N/A","http://selleckchem.com/products/stattic.html","C8H5NO4S","free base","N/A","[O-][N+](=O)C1=CC=C2C=C[S](=O)(=O)C2=C1",0.939,2,0,1]
["S7028","Duvelisib (IPI-145)","a3","L6200-16","in 10mM DMSO","PI3K","Angiogenesis","Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.",416.86,"1201438-56-3",{"v":83,"d":"83.00"},199.11,"<1","N/A","http://selleckchem.com/products/ipi-145-ink1197.html","C22H17ClN6O","free base","INK1197","CC(NC1=NC=NC2=C1N=C[NH]2)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)Cl",3.648,4,2,4]
["S7029","AZD2461","b3","L6200-16","in 10mM DMSO","PARP","DNA Damage/DNA Repair","AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.",395.43,"1174043-16-3",{"v":79,"d":"79.00"},199.78,"<1","N/A","http://selleckchem.com/products/azd2461.html","C22H22FN3O3","free base","N/A","COC1CCN(CC1)C(=O)C2=CC(=CC=C2F)CC3=NNC(=O)C4=CC=CC=C34",1.993,4,1,4]
["S7030","RG-7112","c3","L6200-16","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7033","GSK2656157","d3","L6200-16","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.",416.45,"1337532-29-2",{"v":32,"d":"32.00"},76.84,"<1","N/A","http://selleckchem.com/products/gsk2656157.html","C23H21FN6O","free base","N/A","C[N]1C=C(C2=C(F)C3=C(C=C2)N(CC3)C(=O)CC4=CC=CC(=N4)C)C5=C(N)N=CN=C15",2.926,4,1,3]
["S7036","XL019","e3","L6200-16","in 10mM DMSO","JAK","JAK/STAT","XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.",444.53,"945755-56-6",{"v":16,"d":"16.00"},35.99,"<1","N/A","http://selleckchem.com/products/xl019.html","C25H28N6O2","free base","N/A","O=C(NC1=CC=C(C=C1)C2=CC=NC(=N2)NC3=CC=C(C=C3)N4CCOCC4)C5CCCN5",3.106,4,3,6]
["S7037","Wnt-C59 (C59)","f3","L6200-16","in 10mM DMSO","PORCN","Stem Cells & Wnt","Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.",379.45,"1243243-89-1",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/wnt-c59-c59.html","C25H21N3O","free base","N/A","CC1=NC=CC(=C1)C2=CC=C(CC(=O)NC3=CC=C(C=C3)C4=CC=CN=C4)C=C2",3.667,3,1,5]
["S7038","Epoxomicin (BU-4061T)","g3","L6200-16","in 10mM DMSO","Apoptosis related,Proteasome","Proteases","Epoxomicin (BU-4061T, Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Epoxomicin promotes apoptosis.",554.72,"134381-21-8",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/epoxomicin-bu-4061t.html","C28H50N4O7","free base","Aids010837","CCC(C)C(NC(=O)C(C(C)CC)N(C)C(C)=O)C(=O)NC(=O)C(NC(CC(C)C)C(=O)C1(C)CO1)C(C)O",1.793,6,4,16]
["S7039","PD168393","h3","L6200-16","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.",369.22,"194423-15-9",{"v":73,"d":"73.00"},197.71,"<1","N/A","http://selleckchem.com/products/pd168393.html","C17H13BrN4O","free base","N/A","BrC1=CC(=CC=C1)NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23",4.043,3,2,4]
["S7041","CX-6258 HCl","a4","L6200-16","in 10mM DMSO","Pim","JAK/STAT","CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.",{"v":498.4,"d":"498.40"},"1353859-00-3",{"v":57,"d":"57.00"},114.37,{"v":89,"d":"89.00"},178.57,"http://selleckchem.com/products/CX-6258.html","C26H24ClN3O3.HCl","Hydrochloride","N/A","Cl.CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)\\C=C4\\C(=O)NC5=C4C=C(Cl)C=C5",4.416,3,1,3]
["S7046","Brefeldin A","b4","L6200-16","in 10mM DMSO","Antibiotics,Apoptosis related,ATPase,Autophagy,CRISPR/Cas9,Mitophagy","Transmembrane Transporters","Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.",280.36,"20350-15-6",{"v":4,"d":"4.00"},14.27,"<1","N/A","http://selleckchem.com/products/brefeldin-a.html","C16H24O4","free base","BFA, Cyanein, Decumbin","CC1CCC/C=C/C2CC(O)CC2C(O)/C=C/C(=O)O1",2.152,2,2,0]
["S7049","Oprozomib (ONX 0912)","c4","L6200-16","in 10mM DMSO","Proteasome","Proteases","Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.",532.61,"935888-69-0",{"v":100,"d":"100.00"},187.75,"<1","N/A","http://selleckchem.com/products/oprozomib-onx-0912.html","C25H32N4O7S","free base","PR-047","COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3",-0.202,8,3,14]
["S7050","AZ20","d4","L6200-16","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM in a cell-free assay, 8-fold selectivity over mTOR.",412.51,"1233339-22-4",{"v":83,"d":"83.00"},201.21,"<1","N/A","http://selleckchem.com/products/az20.html","C21H24N4O3S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=O)=O)C4=CC=CC5=C4C=C[NH]5",3.038,5,1,4]
["S7051","CGI1746","e4","L6200-16","in 10mM DMSO","BTK","Angiogenesis","CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM.",579.69,"910232-84-7",{"v":100,"d":"100.00"},172.51,"<1","N/A","http://selleckchem.com/products/cgi1746.html","C34H37N5O4","free base","N/A","CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N3CCOCC3)C1=O)C4=CC=CC(=C4C)NC(=O)C5=CC=C(C=C5)C(C)(C)C",3.513,5,2,7]
["S7063","LY2090314","f4","L6200-16","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.",512.53,"603288-22-8",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/ly2090314.html","C28H25FN6O3","free base","N/A","FC1=CC2=C3[N](CCN(C2)C(=O)N4CCCCC4)C=C(C3=C1)C5=C(C(=O)NC5=O)C6=CN=C7C=CC=C[N]67",2.707,4,1,2]
["S7065","MK-8745","g4","L6200-16","in 10mM DMSO","Aurora Kinase","Cell Cycle","MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.",431.91,"885325-71-3",{"v":86,"d":"86.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-8745.html","C20H19ClFN5OS","free base","N/A","FC1=C(C=CC=C1Cl)C(=O)N2CCN(CC2)CC3=CC=CC(=N3)NC4=NC=CS4",3.805,3,1,5]
["S7067","Tepotinib (EMD 1214063)","h4","L6200-16","in 10mM DMSO","Autophagy,c-Met","Protein Tyrosine Kinase","Tepotinib (EMD 1214063, MSC2156119) is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib (EMD 1214063) induces autophagy. Phase 1.",492.57,"1100598-32-0",{"v":5,"d":"5.00"},10.15,"<1","N/A","http://selleckchem.com/products/emd-1214063.html","C29H28N6O2","free base","MSC2156119","CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4N=C(C=CC4=O)C5=CC(=CC=C5)C#N",3.629,5,0,7]
["S7070","GSK J4 HCl (GSKJ4 HCl)","a5","L6200-16","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.",453.96,"1797983-09-5",{"v":90,"d":"90.00"},198.26,{"v":90,"d":"90.00"},198.26,"http://selleckchem.com/products/gsk-j4-hcl.html","C24H27N5O2.HCl","Hydrochloride","N/A","Cl.CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",4.663,5,1,8]
["S7079","SGC 0946","b5","L6200-16","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.",618.57,"1561178-17-3",{"v":100,"d":"100.00"},161.66,"<1","N/A","http://selleckchem.com/products/sgc-0946.html","C28H40BrN7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=C(Br)C4=C3N=CN=C4N",3.278,4,5,10]
["S7083","Ceritinib (LDK378)","c5","L6200-16","in 10mM DMSO","ALK,FLT3,IGF-1R,Serine/threonin kinase","Protein Tyrosine Kinase","Ceritinib (LDK378) is a potent inhibitor against ALK with IC50 of 0.2 nM in cell-free assays. Ceritinib (LDK378) also inhibits IGF-1R, InsR, STK22D and FLT3 with IC50 of 8 nM, 7 nM, 23 nM and 60 nM, respectively. Phase 3.",558.14,"1032900-25-6",{"v":20,"d":"20.00"},35.83,"<1","N/A","http://selleckchem.com/products/ldk378.html","C28H36ClN5O3S","free base","N/A","CC(C)OC1=C(NC2=NC(=C(Cl)C=N2)NC3=C(C=CC=C3)[S](=O)(=O)C(C)C)C=C(C)C(=C1)C4CCNCC4",6.479,5,3,9]
["S7086","IWR-1-endo","d5","L6200-16","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.",409.44,"1127442-82-3",{"v":21,"d":"21.00"},51.29,"<1","N/A","http://selleckchem.com/products/iwr-1-endo.html","C25H19N3O3","free base","endo-IWR 1, IWR-1","CC12C3CC(C=C3)C1C(=O)N(C2=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6",3.075,4,1,3]
["S7087","GSK2334470","e5","L6200-16","in 10mM DMSO","PDPK1","PI3K/Akt/mTOR","GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM in a cell-free assay, with no activity at other close related AGC-kinases.",462.59,"1227911-45-6",{"v":90,"d":"90.00"},194.56,"<1","N/A","http://selleckchem.com/products/gsk2334470.html","C25H34N8O","free base","N/A","CNC1=NC(=CC(=N1)N2CC(CCC2C)C(=O)NC3CCCCC3)C4=CC5=C(C=C4)C(=N[NH]5)N",4.516,4,4,5]
["S7088","UNC1215","f5","L6200-16","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.",529.72,"1415800-43-9",{"v":100,"d":"100.00"},188.78,"<1","N/A","http://selleckchem.com/products/nuc1215.html","C32H43N5O2","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6",3.351,2,1,6]
["S7090","GSK923295","g5","L6200-16","in 10mM DMSO","Apoptosis related,Kinesin","Cytoskeletal Signaling","GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.",592.13,"1088965-37-0",{"v":100,"d":"100.00"},168.88,"<1","N/A","http://selleckchem.com/products/gsk923295.html","C32H38ClN5O4","free base","N/A","CC(C)OC1=CC=C(C=C1Cl)C(=O)NC(CNC(=O)CN(C)C)CC2=CC=C(C=C2)C3=C[N]4C=CC=C(C(C)O)C4=N3",4.004,4,3,12]
["S7091","Zotarolimus (ABT-578)","h5","L6200-16","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Zotarolimus (ABT-578,A 179578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.",966.21,"221877-54-9",{"v":100,"d":"100.00"},{"v":103.5,"d":"103.50"},"<1","N/A","http://selleckchem.com/products/zotarolimus-abt-578.html","C52H79N5O12","free base","A 179578","COC1CC(CCC1[N]2C=NN=N2)CC(C)C3CC(=O)C(C)/C=C(C)/C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC4CCC(C)C(O)(O4)C(=O)C(=O)N5CCCCC5C(=O)O3)OC",5.793,13,1,7]
["S7092","SANT-1","a6","L6200-16","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.",373.49,"304909-07-7",{"v":21,"d":"21.00"},56.23,"<1","N/A","http://selleckchem.com/products/sant-1.html","C23H27N5","free base","N/A","CC1=N[N](C2=CC=CC=C2)C(=C1\\C=N\\N3CCN(CC3)CC4=CC=CC=C4)C",3.759,2,0,5]
["S7093","IPA-3","b6","L6200-16","in 10mM DMSO","PAK","Cytoskeletal Signaling","IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).",350.45,"42521-82-4",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/ipa-3.html","C20H14O2S2","free base","N/A","OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O",5.871,0,2,3]
["S7094","PF-3758309","c6","L6200-16","in 10mM DMSO","Apoptosis related,PAK","Cytoskeletal Signaling","PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4  with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.",490.62,"898044-15-0",{"v":98,"d":"98.00"},199.75,"<1","N/A","http://selleckchem.com/products/pf-3758309.html","C25H30N8OS","free base","PF-03758309","CN(C)CC(NC(=O)N1CC2=C([NH]N=C2NC3=NC(=NC4=C3SC=C4)C)C1(C)C)C5=CC=CC=C5",4.077,4,3,6]
["S7096","KY02111","d6","L6200-16","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.",376.86,"1118807-13-8",{"v":75,"d":"75.00"},199.01,"<1","N/A","http://selleckchem.com/products/ky02111.html","C18H17ClN2O3S","free base","N/A","COC1=CC=C(CCC(=O)NC2=NC3=CC=C(Cl)C=C3S2)C=C1OC",4.362,4,1,6]
["S7097","HSP990 (NVP-HSP990)","e6","L6200-16","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","HSP990 (NVP-HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM. NVP-HSP990 induces cell cycle arrest and apoptosis.",379.39,"934343-74-5",{"v":75,"d":"75.00"},197.69,"<1","N/A","http://selleckchem.com/products/hsp990-nvp-hsp990.html","C20H18FN5O2","free base","N/A","COC1=NC(=CC=C1)C2=C(C=CC(=C2)F)C3CC4=C(C(=NC(=N4)N)C)C(=O)N3",2.669,5,2,3]
["S7102","Berzosertib (VE-822)","f6","L6200-16","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.",463.55,"1232416-25-9",{"v":36,"d":"36.00"},77.66,"<1","N/A","http://selleckchem.com/products/ve-822.html","C24H25N5O3S","free base","VX970, M6620","CNCC1=CC=C(C=C1)C2=NOC(=C2)C3=C(N)N=CC(=N3)C4=CC=C(C=C4)[S](=O)(=O)C(C)C",3.697,6,2,7]
["S7103","Taselisib (GDC 0032)","g6","L6200-16","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Taselisib (GDC 0032, RG7604) is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with Ki of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.",460.53,"1282512-48-4",{"v":70,"d":"70.00"},{"v":152,"d":"152.00"},"<1","N/A","http://selleckchem.com/products/gdc-0032.html","C24H28N8O2","free base","RG7604","CC(C)[N]1N=C(C)N=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)C5=C[N](N=C5)C(C)(C)C(N)=O",{"v":2.47,"d":"2.470"},6,1,5]
["S7104","AZD1208","h6","L6200-16","in 10mM DMSO","Apoptosis related,Autophagy,Pim","JAK/STAT","AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.",379.48,"1204144-28-4",{"v":75,"d":"75.00"},197.64,"<1","N/A","http://selleckchem.com/products/azd-1208.html","C21H21N3O2S","free base","N/A","NC1CCCN(C1)C2=C(C=CC=C2C3=CC=CC=C3)\\C=C\\4SC(=O)NC4=O",3.283,2,2,3]
["S7106","AZD3463","a7","L6200-16","in 10mM DMSO","ALK,Apoptosis related,Autophagy,IGF-1R","Protein Tyrosine Kinase","AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy.",448.95,"1356962-20-3",{"v":24,"d":"24.00"},53.46,"<1","N/A","http://selleckchem.com/products/azd3463.html","C24H25ClN6O","free base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)C3=C[NH]C4=C3C=CC=C4)C=CC(=C1)N5CCC(N)CC5",4.316,3,3,5]
["S7110","(+)-JQ1","b7","L6200-16","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1","N/A","http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7113","Zebularine (NSC 309132)","c7","L6200-16","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay.",{"v":228.2,"d":"228.20"},"3690-10-6",{"v":46,"d":"46.00"},201.58,{"v":46,"d":"46.00"},201.58,"http://selleckchem.com/products/zebularine.html","C9H12N2O5","free base","4-Deoxyuridine","OCC1OC(C(O)C1O)N2C=CC=NC2=O",-1.747,3,3,2]
["S7119","Go6976","d7","L6200-16","in 10mM DMSO","FLT3,JAK,PKC","TGF-beta/Smad","Go6976 (PD406976) is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.",377.42,"136194-77-9",{"v":18,"d":"18.00"},47.69,"<1","N/A","http://selleckchem.com/products/go6976.html","C24H18N4O","free base","PD406976","C[N]1C2=C(C=CC=C2)C3=C1C4=C(C5=C3C(=O)NC5)C6=C(C=CC=C6)[N]4CCC#N",4.168,1,1,2]
["S7122","XL888","e7","L6200-16","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1.",503.64,"1149705-71-4",{"v":100,"d":"100.00"},198.55,"<1","N/A","http://selleckchem.com/products/xl888.html","C29H37N5O3","free base","N/A","CCC(C)NC1=C(C=C(C)C(=C1)C(=O)NC2CC3CCC(C2)N3C4=NC=C(C=C4)C(=O)C5CC5)C(N)=O",3.772,4,3,9]
["S7127","TIC10 Analogue","f7","L6200-16","in 10mM DMSO","Akt","PI3K/Akt/mTOR","TIC10 Analogue is an analogue of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"41276-02-2",{"v":11,"d":"11.00"},28.46,"<1","N/A","http://selleckchem.com/products/tic10.html","C24H26N4O","free base","N/A","CC1=C(CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5CCN=C25)C=CC=C1",3.212,2,0,4]
["S7129","PYR-41","g7","L6200-16","in 10mM DMSO","Apoptosis related,E1 Activating","Ubiquitin","PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. PYR-41 induce apoptosis.",{"v":371.3,"d":"371.30"},"418805-02-4",{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/pyr-41.html","C17H13N3O7","free base","N/A","CCOC(=O)C1=CC=C(C=C1)N2NC(=O)C(=C/C3=CC=C(O3)[N+]([O-])=O)/C2=O",{"v":1.87,"d":"1.870"},5,1,6]
["S7130","PR-619","h7","L6200-16","in 10mM DMSO","Autophagy,DUB","Ubiquitin","PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.",223.28,"2645-32-1",{"v":45,"d":"45.00"},201.54,"<1","N/A","http://selleckchem.com/products/pr-619.html","C7H5N5S2","free base","N/A","NC1=C(SC#N)C=C(SC#N)C(=N1)N",1.212,1,2,2]
["S7132","P5091 (P005091)","a8","L6200-16","in 10mM DMSO","DUB","Ubiquitin","P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.",348.22,"882257-11-6",{"v":28,"d":"28.00"},80.41,"<1","N/A","http://selleckchem.com/products/p5091-p005091.html","C12H7Cl2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=CC(=C2Cl)Cl)[N+]([O-])=O",4.989,1,0,4]
["S7133","P22077","b8","L6200-16","in 10mM DMSO","DUB","Ubiquitin","P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.",315.32,"1247819-59-5",{"v":63,"d":"63.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/p22077.html","C12H7F2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=C(F)C=C2F)[N+]([O-])=O",4.071,1,0,4]
["S7134","IU1","c8","L6200-16","in 10mM DMSO","Autophagy,DUB","Proteases","IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy.",300.37,"314245-33-5",{"v":60,"d":"60.00"},199.75,"<1","N/A","http://selleckchem.com/products/iu1.html","C18H21FN2O","free base","N/A","CC1=CC(=C(C)[N]1C2=CC=C(F)C=C2)C(=O)CN3CCCC3",3.409,1,0,4]
["S7135","LDN-57444","d8","L6200-16","in 10mM DMSO","DUB","Proteases","LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.",397.64,"668467-91-2",{"v":11,"d":"11.00"},27.66,"<1","N/A","http://selleckchem.com/products/ldn-57444.html","C17H11Cl3N2O3","free base","N/A","CC(=O)O\\N=C/1C(=O)N(CC2=CC(=CC=C2Cl)Cl)C3=CC=C(Cl)C=C13",4.343,4,0,4]
["S7136","CGK 733","e8","L6200-16","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.",555.84,"905973-89-9",{"v":100,"d":"100.00"},179.91,"<1","N/A","http://selleckchem.com/products/cgk-733.html","C23H18Cl3FN4O3S","free base","N/A","[O-][N+](=O)C1=CC(=CC=C1F)NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)C(Cl)(Cl)Cl",6.795,1,3,10]
["S7137","GLPG0634 analogue","f8","L6200-16","in 10mM DMSO","JAK","JAK/STAT","GLPG0634 analogue is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.",410.43,"1206101-20-3",{"v":82,"d":"82.00"},199.79,"<1","N/A","http://www.selleck.cn/products/glpg0634.html","C23H18N6O2","Free Base","N/A","O=C(NC1=N[N]2C(=N1)C=CC=C2C3=CC=C(OCC4=CC=C(N=C4)C#N)C=C3)C5CC5",3.695,5,1,6]
["S7138","BMS-833923","g8","L6200-16","in 10mM DMSO","Hedgehog/Smoothened","GPCR & G Protein","BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.",473.57,"1059734-66-5",{"v":95,"d":"95.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://selleckchem.com/products/bms-833923.html","C30H27N5O","free base","XL139","CNCC1=CC(=C(C)C=C1)NC(=O)C2=CC=C(NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5)C=C2",6.214,3,3,7]
["S7140","TCID","h8","L6200-16","in 10mM DMSO","DUB","Ubiquitin","TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.",283.92,"30675-13-9",{"v":23,"d":"23.00"},81.01,"<1","N/A","http://selleckchem.com/products/tcid.html","C9H2Cl4O2","free base","N/A","ClC1=C(Cl)C(=C2C(=O)CC(=O)C2=C1Cl)Cl",3.982,2,0,0]
["S7142","NSC697923","a9","L6200-16","in 10mM DMSO","E2 conjugating","Ubiquitin","NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.",267.26,"343351-67-7",{"v":53,"d":"53.00"},198.31,"<1","N/A","http://selleckchem.com/products/nsc697923.html","C11H9NO5S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(O2)[N+]([O-])=O",2.665,3,0,3]
["S7143","LGK-974","b9","L6200-16","in 10mM DMSO","PORCN","Stem Cells & Wnt","LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.",396.44,"1243244-14-5",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://selleckchem.com/products/lgk-974.html","C23H20N6O","free base","NVP-LGK974, WNT974","CC1=CC(=CC=N1)C2=C(C)C=C(CC(=O)NC3=CC=C(C=N3)C4=CN=CC=N4)C=N2",2.098,6,1,5]
["S7144","BMS-911543","c9","L6200-16","in 10mM DMSO","JAK","JAK/STAT","BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.",432.52,"1271022-90-2",{"v":36,"d":"36.00"},83.23,"<1","N/A","http://selleckchem.com/products/bms-911543.html","C23H28N8O","free base","N/A","CC[N]1C(=CC2=C1N=C(NC3=N[N](C)C(=C3)C)C4=C2[N](C)C=N4)C(=O)N(C5CC5)C6CC6",3.556,4,1,6]
["S7145","AZD1080","d9","L6200-16","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.",334.37,"612487-72-6",{"v":52,"d":"52.00"},155.52,"<1","N/A","http://selleckchem.com/products/azd1080.html","C19H18N4O2","free base","N/A","OC1=C(C2=CC=C(CN3CCOCC3)C=N2)C4=CC(=CC=C4[NH]1)C#N",2.442,2,2,3]
["S7146","DMH1","e9","L6200-16","in 10mM DMSO","Autophagy,TGF-beta/Smad","TGF-beta/Smad","DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. DMH1 inhibits autophagy.",380.44,"1206711-16-1",{"v":22,"d":"22.00"},57.83,"<1","N/A","http://selleckchem.com/products/dmh1.html","C24H20N4O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CC=NC5=C4C=CC=C5",4.036,4,0,4]
["S7147","LDN-212854","f9","L6200-16","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LDN-212854 (BMP Inhibitor III) is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.",406.48,"1432597-26-6",{"v":81,"d":"81.00"},199.27,"<1","N/A","http://selleckchem.com/products/ldn-212854.html","C25H22N6","free base","BMP Inhibitor III","C1CN(CCN1)C2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=CC6=C5C=CC=N6",2.909,3,1,3]
["S7148","ML347","g9","L6200-16","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","ML347 (LDN-193719) is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM.",352.39,"1062368-49-3",{"v":10,"d":"10.00"},28.38,"<1","N/A","http://selleckchem.com/products/ml347.html","C22H16N4O","free base","LDN-193719","COC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CC=CC5=C4C=CC=N5",3.309,4,0,3]
["S7149","NSC 319726","h9","L6200-16","in 10mM DMSO","p53","Apoptosis","NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.",234.32,"71555-25-4",{"v":19,"d":"19.00"},81.09,"<1","N/A","http://selleckchem.com/products/nsc319726.html","C11H14N4S","free base","N/A","CC(=N\\NC(=S)N1CCC1)/C2=NC=CC=C2",1.906,2,1,4]
["S7152","C646","a10","L6200-16","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy.",445.42,"328968-36-1",{"v":13,"d":"13.00"},29.19,"<1","N/A","http://selleckchem.com/products/c646.html","C24H19N3O6","free base","N/A","CC1=C(C)C=C(C(=C1)C2=CC=C(O2)\\C=C/3C(=NN(C3=O)C4=CC=C(C=C4)C(O)=O)C)[N+]([O-])=O",4.736,4,0,5]
["S7155","Batimastat (BB-94)","b10","L6200-16","in 10mM DMSO","MMP","Proteases","Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.",477.64,"130370-60-4",{"v":96,"d":"96.00"},200.99,"<1","N/A","http://selleckchem.com/products/bb-94.html","C23H31N3O4S2","free base","N/A","CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(C)C)C(CSC2=CC=CS2)C(=O)NO",3.218,3,3,12]
["S7156","Marimastat (BB-2516)","c10","L6200-16","in 10mM DMSO","MMP","Proteases","Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.",331.41,"154039-60-8",{"v":54,"d":"54.00"},162.94,"<1","N/A","http://selleckchem.com/products/marimastat.html","C15H29N3O5","free base","TA2516","CNC(=O)C(NC(=O)C(CC(C)C)C(O)C(=O)NO)C(C)(C)C",0.239,3,4,8]
["S7157","Ilomastat","d10","L6200-16","in 10mM DMSO","MMP","Proteases","Ilomastat (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively.",388.46,"142880-36-2",{"v":78,"d":"78.00"},200.79,"<1","N/A","http://selleckchem.com/products/gm6001.html","C20H28N4O4","free base","GM6001, Galardin","CNC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CC(C)C)CC(=O)NO",1.624,3,4,9]
["S7158","Abemaciclib mesylate (LY2835219)","e10","L6200-16","in 10mM DMSO","CDK","Cell Cycle","Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.",{"v":602.7,"d":"602.70"},"1231930-82-7",{"v":83,"d":"83.00"},137.71,{"v":100,"d":"100.00"},165.92,"http://selleckchem.com/products/ly2835219.html","C27H32F2N8.CH4O3S","mesylate","N/A","CCN1CCN(CC1)CC2=CC=C(NC3=NC(=C(F)C=N3)C4=CC(=C5N=C(C)[N](C(C)C)C5=C4)F)N=C2.C[S](O)(=O)=O",4.543,4,1,7]
["S7160","Glasdegib (PF-04449913)","f10","L6200-16","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.",374.44,"1095173-27-5",{"v":47,"d":"47.00"},125.52,"<1","N/A","http://selleckchem.com/products/glasdegib-pf-04449913.html","C21H22N6O","Free Base","N/A","CN1CCC(CC1C2=NC3=CC=CC=C3[NH]2)NC(=O)NC4=CC=C(C=C4)C#N",2.363,2,3,3]
["S7162","Mdivi-1","g10","L6200-16","in 10mM DMSO","Apoptosis related,Dynamin,Mitophagy","Cytoskeletal Signaling","Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhances apoptosis.",353.22,"338967-87-6",{"v":70,"d":"70.00"},198.18,"<1","N/A","http://selleckchem.com/products/mdivi-1.html","C15H10Cl2N2O2S","free base","Mitochondrial division inhibitor 1","COC1=C(Cl)C=C(Cl)C(=C1)N2C(=NC3=C(C=CC=C3)C2=O)S",4.943,3,0,2]
["S7165","UNC1999","h10","L6200-16","in 10mM DMSO","Apoptosis related,Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.",569.74,"1431612-23-5",{"v":50,"d":"50.00"},87.76,"<1","N/A","http://selleckchem.com/products/unc1999.html","C33H43N7O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(CC5)C(C)C)C(=O)NC(=C1)C",4.629,4,2,9]
["S7169","Crenigacestat (LY3039478)","a11","L6200-16","in 10mM DMSO","Gamma-secretase,Notch","Stem Cells & Wnt","Crenigacestat (LY3039478) is an oral Notch and gamma-secretase inhibitor with IC50 of 0.41 nM for Notch.",464.44,"1421438-81-4",{"v":92,"d":"92.00"},198.09,"<1","N/A","http://selleckchem.com/products/ly3039478.html","C22H23F3N4O4","free base","N/A","CC(NC(=O)CCC(F)(F)F)C(=O)NC1C(=O)N(CCO)C2=C(C=CC=N2)C3=C1C=CC=C3",1.395,4,3,8]
["S7171","Setanaxib (GKT137831)","b11","L6200-16","in 10mM DMSO","Ferroptosis,NADPH-oxidase,ROS","Immunology & Inflammation","Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.",394.85,"1218942-37-0",{"v":78,"d":"78.00"},197.54,"<1","N/A","http://selleckchem.com/products/gkt137831.html","C21H19ClN4O2","free base","GKT831","CN(C)C1=CC=CC(=C1)C2=C3C(=O)N(NC3=CC(=O)N2C)C4=CC=CC=C4Cl",2.366,2,1,3]
["S7176","SKI II","c11","L6200-16","in 10mM DMSO","SPHK","Immunology & Inflammation","SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.",302.78,"312636-16-1",{"v":61,"d":"61.00"},201.47,"<1","N/A","http://selleckchem.com/products/ski-ii.html","C15H11ClN2OS","free base","SphK-I2","OC1=CC=C(NC2=NC(=CS2)C3=CC=C(Cl)C=C3)C=C1",4.746,1,2,3]
["S7189","Molibresib (I-BET-762)","d11","L6200-16","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.",{"v":423.9,"d":"423.90"},"1260907-17-2",{"v":84,"d":"84.00"},198.16,"<1","N/A","http://selleckchem.com/products/i-bet-762.html","C22H22ClN5O2","free base","GSK525762, GSK525762A","CCNC(=O)CC1N=C(C2=CC=C(Cl)C=C2)C3=CC(=CC=C3[N]4C(=NN=C14)C)OC",3.288,5,1,5]
["S7193","1-Azakenpaullone","e11","L6200-16","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","1-Azakenpaullone (1-Akp) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.",328.16,"676596-65-9",{"v":66,"d":"66.00"},201.12,"<1","N/A","http://selleckchem.com/products/1-azakenpaullone.html","C15H10BrN3O","free base","1-Akp","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3N=CC=C4)C=C1",2.949,2,2,0]
["S7195","RKI-1447","f11","L6200-16","in 10mM DMSO","ROCK","Cell Cycle","RKI-1447 is a potent inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, has anti-invasive and antitumor activities.",326.37,"1342278-01-6",{"v":65,"d":"65.00"},199.16,"<1","N/A","http://selleckchem.com/products/rki-1447.html","C16H14N4O2S","free base","N/A","OC1=CC(=CC=C1)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3",2.081,3,3,4]
["S7198","BIO","g11","L6200-16","in 10mM DMSO","Apoptosis related,CDK,GSK-3,JAK","PI3K/Akt/mTOR","BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.",356.17,"667463-62-9",{"v":71,"d":"71.00"},199.34,"<1","N/A","http://selleckchem.com/products/bio.html","C16H10BrN3O2","free base","GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052","O\\N=C/1\\C(NC2=CC=CC=C12)=C3\\C(=O)NC4=C3C=CC(=C4)Br",2.692,2,2,0]
["S7199","DBeQ","h11","L6200-16","in 10mM DMSO","p97","Ubiquitin","DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.",340.42,"177355-84-9",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://selleckchem.com/products/dbeq.html","C22H20N4","free base","JRF 12","C(NC1=NC2=CC=CC=C2C(=N1)NCC3=CC=CC=C3)C4=CC=CC=C4",5.232,2,2,6]
["S7205","Idasanutlin (RG-7388)","a2","L6200-17","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7207","Bisindolylmaleimide IX (Ro 31-8220 Mesylate)","b2","L6200-17","in 10mM DMSO","PKC","TGF-beta/Smad","Bisindolylmaleimide IX (Ro 31-8220 Mesylate) is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.",553.65,"138489-18-6",{"v":100,"d":"100.00"},180.62,"<1","N/A","http://selleckchem.com/products/ro-31-8220-mesylate.html","C25H23N5O2S.CH4O3S","Mesylate","Bisindolylmaleimide IX Mesylate","C[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[N](CCCSC(N)=N)C5=CC=CC=C45.C[S](O)(=O)=O",3.452,2,2,7]
["S7208","Bisindolylmaleimide I (GF109203X)","c2","L6200-17","in 10mM DMSO","PKC","TGF-beta/Smad","Bisindolylmaleimide I (GF109203X, GO 6850) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.",412.48,"133052-90-1",{"v":82,"d":"82.00"},{"v":198.8,"d":"198.80"},"<1","N/A","http://selleckchem.com/products/gf109203x.html","C25H24N4O2","free base","GO 6850","CN(C)CCC[N]1C=C(C2=CC=CC=C12)C3=C(C(=O)NC3=O)C4=C[NH]C5=CC=CC=C45",3.557,2,2,6]
["S7213","Thiamet G","d2","L6200-17","in 10mM DMSO","OGA","Autophagy","Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.",{"v":248.3,"d":"248.30"},"1009816-48-1",{"v":50,"d":"50.00"},201.37,{"v":50,"d":"50.00"},201.37,"http://selleckchem.com/products/thiamet-g.html","C9H16N2O4S","free base","N/A","CCNC1=NC2C(O)C(O)C(CO)OC2S1",-0.613,2,4,3]
["S7214","Skepinone-L","e2","L6200-17","in 10mM DMSO","p38 MAPK","MAPK","Skepinone-L (CBS3830) is a selective p38α-MAPK inhibitor with IC50 of 5 nM.",425.42,"1221485-83-1",{"v":85,"d":"85.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/skepinone-l.html","C24H21F2NO4","free base","CBS3830","OCC(O)COC1=CC=C2CCC3=CC(=CC=C3C(=O)C2=C1)NC4=CC=C(F)C=C4F",4.729,2,3,6]
["S7215","Losmapimod (GW856553X)","f2","L6200-17","in 10mM DMSO","Apoptosis related,Autophagy,p38 MAPK","MAPK","Losmapimod (GW856553X, GW856553, GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. P38 MAPKs are involved in cell differentiation, apoptosis and autophagy. Phase 3.",383.46,"585543-15-3",{"v":76,"d":"76.00"},{"v":198.2,"d":"198.20"},"<1","N/A","http://selleckchem.com/products/losmapimod-gw856553x.html","C22H26FN3O2","free base","GW856553, GSK-AHAB","CC1=C(F)C=C(C=C1C2=CC=C(C=N2)C(=O)NCC(C)(C)C)C(=O)NC3CC3",3.689,3,2,6]
["S7217","OAC1","g2","L6200-17","in 10mM DMSO","OCT","Stem Cells & Wnt","OAC1 (Oct4-activating compound 1, BAS 00287861) can enhance the efficiency of reprogramming. OAC1 can activate both Oct4 and Nanog promoter-driven luciferase reporter genes.",237.26,"300586-90-7",{"v":47,"d":"47.00"},198.09,"<1","N/A","http://selleckchem.com/products/oac1.html","C14H11N3O","free base","BAS 00287861","O=C(NC1=CC2=C([NH]C=C2)C=N1)C3=CC=CC=C3",2.296,2,2,2]
["S7218","Alvelestat (AZD9668)","h2","L6200-17","in 10mM DMSO","Serine Protease","Proteases","Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.\n\n Phase 2.",545.53,"848141-11-7",{"v":100,"d":"100.00"},183.31,"<1","N/A","http://selleckchem.com/products/avelestat-azd9668.html","C25H22F3N5O4S","free base","Avelestat","C[N]1N=CC=C1C2=CN(C(=O)C(=C2)C(=O)NCC3=NC=C(C=C3)[S](C)(=O)=O)C4=CC=CC(=C4)C(F)(F)F",2.163,6,1,7]
["S7223","RepSox (E-616452)","a3","L6200-17","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively.",287.32,"446859-33-2",{"v":57,"d":"57.00"},198.39,"<1","N/A","http://selleckchem.com/products/repsox.html","C17H13N5","free base","SJN 2511,ALK5 Inhibitor II","CC1=CC=CC(=N1)C2=N[NH]C=C2C3=CC=C4N=CC=CC4=N3",3.192,4,1,2]
["S7229","RGFP966","b3","L6200-17","in 10mM DMSO","HDAC","Epigenetics","RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.",{"v":362.4,"d":"362.40"},"1396841-57-8",{"v":72,"d":"72.00"},198.68,"<1","N/A","http://selleckchem.com/products/rgfp966.html","C21H19FN4O","free base","N/A","NC1=CC(=CC=C1NC(=O)\\C=C\\C2=C[N](C\\C=C\\C3=CC=CC=C3)N=C2)F",3.242,2,2,6]
["S7230","UNC0642","c3","L6200-17","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.",{"v":546.7,"d":"546.70"},"1481677-78-4",{"v":100,"d":"100.00"},182.92,"<1","N/A","http://selleckchem.com/products/unc0642.html","C29H44F2N6O2","free base","N/A","COC1=CC2=C(C=C1OCCCN3CCCC3)N=C(N=C2NC4CCN(CC4)C(C)C)N5CCC(F)(F)CC5",4.706,4,1,10]
["S7231","GSK2801","d3","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively.",371.45,"1619994-68-1",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://selleckchem.com/products/gsk2801.html","C20H21NO4S","free base","N/A","CCCOC1=CC2=C(C=C([N]2C=C1)C(C)=O)C3=C(C=CC=C3)[S](C)(=O)=O",3.594,4,0,6]
["S7233","Bromosporine","e3","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.",404.44,"1619994-69-2",{"v":81,"d":"81.00"},200.28,"<1","N/A","http://selleckchem.com/products/bromosporine.html","C17H20N6O4S","free base","N/A","CCOC(=O)NC1=CC(=N[N]2C(=NN=C12)C)C3=CC(=C(C)C=C3)N[S](C)(=O)=O",{"v":1.57,"d":"1.570"},7,2,6]
["S7234","IOX1","f3","L6200-17","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 is an inhibitor of ALKBH5.",189.17,"5852-78-8",{"v":37,"d":"37.00"},195.59,"<1","N/A","http://selleckchem.com/products/iox1.html","C10H7NO3","free base","N/A","OC(=O)C1=CC=C(O)C2=NC=CC=C12",1.404,2,1,1]
["S7237","OG-L002","g3","L6200-17","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.",225.29,"1357302-64-7",{"v":45,"d":"45.00"},199.74,"<1","N/A","http://selleckchem.com/products/og-l002.html","C15H15NO","free base","N/A","NC1CC1C2=CC=C(C=C2)C3=CC=CC(=C3)O",{"v":2.47,"d":"2.470"},0,2,2]
["S7238","NVP-TNKS656","h3","L6200-17","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NVP-TNKS656 is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.",494.58,"1419949-20-4",{"v":100,"d":"100.00"},202.19,"<1","N/A","http://selleckchem.com/products/nvp-tnks656.html","C27H34N4O5","free base","N/A","COC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)N(CC3CC3)CC4=NC5=C(COCC5)C(=O)N4",1.014,6,1,9]
["S7239","G007-LK","a4","L6200-17","in 10mM DMSO","PARP","DNA Damage/DNA Repair","G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.",529.96,"1380672-07-0",{"v":100,"d":"100.00"},188.69,"<1","N/A","http://selleckchem.com/products/g007-lk.html","C25H16ClN7O3S","free base","N/A","C[S](=O)(=O)C1=CN=C(C=C1)C2=NN=C(\\C=C\\C3=NN=C(O3)C4=CC=C(C=C4)C#N)[N]2C5=CC=CC=C5Cl",4.347,8,0,6]
["S7248","Ro3280","b4","L6200-17","in 10mM DMSO","PLK","Cell Cycle","RO3280 (Ro5203280) is a potent, highly selective inhibitor of  Polo-like kinase 1 (PLK1) with IC50 of 3 nM.",543.61,"1062243-51-9",{"v":100,"d":"100.00"},183.96,"<1","N/A","http://selleckchem.com/products/ro3280.html","C27H35F2N7O3","free base","Ro5203280","COC1=C(NC2=NC3=C(C=N2)N(C)C(=O)C(F)(F)CN3C4CCCC4)C=CC(=C1)C(=O)NC5CCN(C)CC5",3.245,5,2,6]
["S7253","AZD2858","c4","L6200-17","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.",453.52,"486424-20-8",{"v":7,"d":"7.00"},15.43,"<1","N/A","http://selleckchem.com/products/azd2858.html","C21H23N7O3S","free base","N/A","CN1CCN(CC1)[S](=O)(=O)C2=CC=C(C=C2)C3=CN=C(N)C(=N3)C(=O)NC4=CN=CC=C4",0.405,6,2,5]
["S7255","Onvansertib (NMS-P937)","d4","L6200-17","in 10mM DMSO","Apoptosis related,PLK","Cell Cycle","Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.",532.52,"1034616-18-6",{"v":42,"d":"42.00"},78.87,"<1","N/A","http://selleckchem.com/products/nms-p937-nms1286937.html","C24H27F3N8O3","free base","PCM-075, NMS1286937","CN1CCN(CC1)C2=CC=C(OC(F)(F)F)C(=C2)NC3=NC4=C(CCC5=C4[N](CCO)N=C5C(N)=O)C=N3",4.742,5,3,8]
["S7256","SGC-CBP30","e4","L6200-17","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.",509.04,"1613695-14-9",{"v":100,"d":"100.00"},196.45,"<1","N/A","http://selleckchem.com/products/sgc-cbp30.html","C28H33ClN4O3","free base","N/A","COC1=C(Cl)C=C(CCC2=NC3=CC(=CC=C3[N]2CC(C)N4CCOCC4)C5=C(C)ON=C5C)C=C1",{"v":5.22,"d":"5.220"},5,0,8]
["S7259","FLLL32","f4","L6200-17","in 10mM DMSO","IFN,Interleukins,JAK","JAK/STAT","FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.",464.55,"1226895-15-3",{"v":92,"d":"92.00"},198.04,"<1","N/A","http://selleckchem.com/products/flll32.html","C28H32O6","free base","N/A","COC1=CC=C(/C=C/C(=O)C2(CCCCC2)C(=O)\\C=C\\C3=CC(=C(OC)C=C3)OC)C=C1OC",5.882,6,0,10]
["S7261","Beta-Lapachone","g4","L6200-17","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.",242.27,"4707-32-8",{"v":33,"d":"33.00"},136.21,"<1","N/A","http://selleckchem.com/products/beta-lapachone.html","C15H14O3","free base","β-Lapachone, ARQ-501","CC1(C)CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O",2.509,3,0,0]
["S7262","Vidofludimus","h4","L6200-17","in 10mM DMSO","COVID-19,Dehydrogenase","Metabolism","Vidofludimus (SC12267, 4SC-101) is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2.",355.36,"717824-30-1",{"v":100,"d":"100.00"},{"v":281.4,"d":"281.40"},"<1","N/A","http://selleckchem.com/products/vidofludimus.html","C20H18FNO4","free base","SC12267, 4SC-101","COC1=CC(=CC=C1)C2=CC(=C(NC(=O)C3=C(CCC3)C(O)=O)C=C2)F",3.878,3,1,5]
["S7265","MM-102","a5","L6200-17","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1  protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM.",{"v":669.8,"d":"669.80"},"1417329-24-8",{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},"http://selleckchem.com/products/mm-102.html","C35H49F2N7O4","free base","HMTase Inhibitor IX","CCC(CC)(NC(=O)C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3",4.419,4,6,17]
["S7270","SRPIN340","b5","L6200-17","in 10mM DMSO","Serine/threonin kinase","Metabolism","SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..",349.35,"218156-96-8",{"v":70,"d":"70.00"},200.37,"<1","N/A","http://selleckchem.com/products/srpin340.html","C18H18F3N3O","free base","N/A","FC(F)(F)C1=CC(=C(C=C1)N2CCCCC2)NC(=O)C3=CC=NC=C3",3.485,2,1,4]
["S7271","FRAX597","c5","L6200-17","in 10mM DMSO","PAK","Cytoskeletal Signaling","FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively.",{"v":558.1,"d":"558.10"},"1286739-19-2",{"v":14,"d":"14.00"},25.09,"<1","N/A","http://selleckchem.com/products/frax597.html","C29H28ClN7OS","free base","N/A","CCN1C(=O)C(=CC2=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N=C12)C5=CC=C(C=C5Cl)C6=CN=CS6",5.166,4,1,6]
["S7272","4μ8C","d5","L6200-17","in 10mM DMSO","IRE1","ER stress & UPR","4μ8C (IRE1 Inhibitor III) is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.",204.18,"14003-96-4",{"v":19,"d":"19.00"},93.06,"<1","N/A","http://selleckchem.com/products/4u8c.html","C11H8O4","free base","IRE1 Inhibitor III","CC1=CC(=O)OC2=C(C=O)C(=CC=C12)O",1.863,3,1,1]
["S7273","SC75741","e5","L6200-17","in 10mM DMSO","Influenza Virus,NF-κB","NF-κB","SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.",565.67,"913822-46-5",{"v":35,"d":"35.00"},61.87,"<1","N/A","http://selleckchem.com/products/sc75741.html","C29H23N7O2S2","free base","N/A","O=C(NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CC=C3)C4=CSC(=N4)C5CCN(CC5)C6=C7SC=CC7=NC=N6",{"v":5.57,"d":"5.570"},6,2,6]
["S7276","SGI-1027","f5","L6200-17","in 10mM DMSO","Apoptosis related,DNA Methyltransferase","Epigenetics","SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.",461.52,"1020149-73-8",{"v":92,"d":"92.00"},199.34,"<1","N/A","http://selleckchem.com/products/sgi-1027.html","C27H23N7O","free base","DNA Methyltransferase Inhibitor II","CC1=CC(=NC(=N1)N)NC2=CC=C(NC(=O)C3=CC=C(NC4=CC=NC5=C4C=CC=C5)C=C3)C=C2",4.718,4,4,6]
["S7278","HPOB","g5","L6200-17","in 10mM DMSO","HDAC","Cytoskeletal Signaling","HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs.",314.34,"1429651-50-2",{"v":62,"d":"62.00"},197.24,"<1","N/A","http://selleckchem.com/products/hpob.html","C17H18N2O4","free base","N/A","OCCN(C(=O)CC1=CC=C(C=C1)C(=O)NO)C2=CC=CC=C2",{"v":1.33,"d":"1.330"},2,2,6]
["S7280","Edoxaban tosylate Monohydrate","h5","L6200-17","in 10mM DMSO","Factor Xa","Metabolism","Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.",738.27,"1229194-11-9",{"v":100,"d":"100.00"},135.45,"<1","N/A","http://selleckchem.com/products/edoxaban.html","C24H30ClN7O4S.C7H8O3S.H2O","Tosylate hydrate","DU-176b","O.CN(C)C(=O)C1CCC(NC(=O)C(=O)NC2=CC=C(Cl)C=N2)C(C1)NC(=O)C3=NC4=C(CN(C)CC4)S3.CC5=CC=C(C=C5)[S](O)(=O)=O",2.286,6,3,7]
["S7281","JIB-04","a6","L6200-17","in 10mM DMSO","Apoptosis related,Histone Demethylase,JMJD","Epigenetics","JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.",308.76,"199596-05-9",{"v":25,"d":"25.00"},80.97,"<1","N/A","http://selleckchem.com/products/jib-04.html","C17H13ClN4","free base","NSC 693627","ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1",4.424,3,1,4]
["S7282","NMS-E973","b6","L6200-17","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.",454.43,"1253584-84-7",{"v":90,"d":"90.00"},198.05,"<1","N/A","http://selleckchem.com/products/nms-e973.html","C22H22N4O7","free base","N/A","CN1CCC(CC1)NC(=O)C2=NOC(=C2)C3=C(OC4=CC=C(C=C4)[N+]([O-])=O)C=C(O)C=C3O",2.811,4,3,6]
["S7285","NMS-873","c6","L6200-17","in 10mM DMSO","p97","Ubiquitin","NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).",520.67,"1418013-75-8",{"v":100,"d":"100.00"},192.06,"<1","N/A","http://selleckchem.com/products/nms-873.html","C27H28N4O3S2","free base","N/A","CC1=CC(=CC=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3=NN=C(SC4CCCC4)[N]3C5=CN=CC=C5",5.602,6,0,8]
["S7289","PFK15","d6","L6200-17","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.",260.29,"4382-63-2",{"v":19,"d":"19.00"},{"v":73,"d":"73.00"},"<1","N/A","http://selleckchem.com/products/pfk15.html","C17H12N2O","free base","PFK-015","O=C(\\C=C\\C1=CC=C2C=CC=CC2=N1)C3=CC=NC=C3",3.166,3,0,3]
["S7291","TAK-632","e6","L6200-17","in 10mM DMSO","Raf","MAPK","TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and C-Raf in cell-free assays, respectively, showing less or no inhibition against other tested kinases.",554.52,"1228591-30-7",{"v":100,"d":"100.00"},180.34,"<1","N/A","http://selleckchem.com/products/tak-632.html","C27H18F4N4O3S","free base","N/A","FC1=C(NC(=O)CC2=CC=CC(=C2)C(F)(F)F)C=C(OC3=C(C#N)C4=C(C=C3)N=C(NC(=O)C5CC5)S4)C=C1",{"v":5.74,"d":"5.740"},4,2,8]
["S7292","RG2833 (RGFP109)","f6","L6200-17","in 10mM DMSO","HDAC","Epigenetics","RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3 in cell-free assays, respectively.",339.43,"1215493-56-3",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://selleckchem.com/products/rg2833-rgfp109.html","C20H25N3O2","free base","N/A","CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N",2.895,2,3,8]
["S7294","PFI-2 HCl","g6","L6200-17","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.",535.98,"1627607-87-7",{"v":99,"d":"99.00"},184.71,{"v":4,"d":"4.00"},7.46,"http://selleckchem.com/products/pfi-2.html","C23H25F4N3O3S.HCl","Hydrochloride","N/A","FC1=CC(=CC2=C1CNCC2)[S](=O)(=O)NC(CC3=CC=CC(=C3)C(F)(F)F)C(=O)N4CCCC4",3.268,3,2,7]
["S7295","Apabetalone (RVX-208)","h6","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.",{"v":370.4,"d":"370.40"},"1044870-39-4",{"v":74,"d":"74.00"},199.78,"<1","N/A","http://selleckchem.com/products/rvx-208.html","C20H22N2O5","free base","RVX-000222","COC1=CC(=C2C(=O)NC(=NC2=C1)C3=CC(=C(OCCO)C(=C3)C)C)OC",2.877,5,2,6]
["S7296","ML324","a7","L6200-17","in 10mM DMSO","CMV,Histone Demethylase,JMJD","Epigenetics","ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.",349.43,"1222800-79-4",{"v":43,"d":"43.00"},123.06,"<1","N/A","http://selleckchem.com/products/ml324.html","C21H23N3O2","free base","N/A","CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC3=CC=CN=C3C(=C2)O",2.701,2,2,6]
["S7297","Osimertinib (AZD9291)","b7","L6200-17","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.",499.61,"1421373-65-0",{"v":99,"d":"99.00"},198.15,"<1","N/A","http://selleckchem.com/products/azd9291.html","C28H33N7O2","free base","Mereletinib","COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",4.671,4,2,10]
["S7300","PJ34 HCl","c7","L6200-17","in 10mM DMSO","PARP","DNA Damage/DNA Repair","PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.",{"v":331.8,"d":"331.80"},"344458-15-7",{"v":66,"d":"66.00"},198.92,{"v":66,"d":"66.00"},198.92,"http://selleckchem.com/products/pj34-hcl.html","C17H17N3O2.HCl","Hydrochloride","N/A","Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=C2C=CC=C3)C=C1",1.811,2,2,3]
["S7301","IWP-L6","d7","L6200-17","in 10mM DMSO","PORCN","Stem Cells & Wnt","IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.",472.58,"1427782-89-5",{"v":25,"d":"25.00"},{"v":52.9,"d":"52.90"},"<1","N/A","http://selleckchem.com/products/iwp-l6.html","C25H20N4O2S2","free base","Porcn Inhibitor III","O=C(CSC1=NC2=C(SCC2)C(=O)N1C3=CC=CC=C3)NC4=NC=C(C=C4)C5=CC=CC=C5",4.072,4,1,6]
["S7304","CPI-203","e7","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","CPI-203 is a potent BET bromodomain inhibitor with IC50 of 37 nM for BRD4.",{"v":399.9,"d":"399.90"},"1446144-04-2",{"v":79,"d":"79.00"},197.55,"<1","N/A","http://selleckchem.com/products/cpi-203.html","C19H18ClN5OS","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(N)=O)N=C2C4=CC=C(Cl)C=C4)C",3.168,4,1,3]
["S7305","MS436","f7","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","MS436 is a selective BET bromodomain inhibitor with Ki of <0.085 μM and 0.34 μM for BRD4 (1) and BRD4 (2), respectively.",383.42,"1395084-25-9",{"v":55,"d":"55.00"},143.45,"<1","N/A","http://selleckchem.com/products/ms436.html","C18H17N5O3S","free base","N/A","CC1=C(O)C=C(N)C(=C1)N=NC2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=N3",3.573,5,3,5]
["S7307","GSK2606414","g7","L6200-17","in 10mM DMSO","Apoptosis related,Autophagy,PERK","Apoptosis","GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.",451.44,"1337531-36-8",{"v":90,"d":"90.00"},199.36,"<1","N/A","http://selleckchem.com/products/gsk2606414.html","C24H20F3N5O","free base","N/A","C[N]1C=C(C2=CC=C3N(CCC3=C2)C(=O)CC4=CC=CC(=C4)C(F)(F)F)C5=C1N=CN=C5N",4.103,3,1,4]
["S7309","BAY 87-2243","h7","L6200-17","in 10mM DMSO","Ferroptosis,HIF,Mitochondrial Metabolism,ROS","Angiogenesis","BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. BAY 87-2243 inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis. BAY 87-2243 exerts antitumor activity. Phase 1.",525.53,"1227158-85-1",{"v":33,"d":"33.00"},62.79,"<1","N/A","http://selleckchem.com/products/bay-87-2243.html","C26H26F3N7O2","Free Base","N/A","CC1=CC(=N[N]1CC2=CC=NC(=C2)N3CCN(CC3)C4CC4)C5=NC(=NO5)C6=CC=C(OC(F)(F)F)C=C6",{"v":6.07,"d":"6.070"},6,0,8]
["S7310","SF1670","a8","L6200-17","in 10mM DMSO","PTEN","PI3K/Akt/mTOR","SF1670 is a highly potent and specific PTEN inhibitor with IC50 of 2 μM.",307.34,"345630-40-2",{"v":29,"d":"29.00"},94.36,"<1","N/A","http://selleckchem.com/products/sf1670.html","C19H17NO3","free base","N/A","CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=C(C=CC=C3)C(=O)C2=O",3.475,3,1,2]
["S7311","Q-VD-Oph","b8","L6200-17","in 10mM DMSO","Caspase,HIV","Apoptosis","Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. Q-VD-OPh can inhibits HIV infection.",513.49,"1135695-98-5",{"v":100,"d":"100.00"},194.75,"<1","N/A","http://selleckchem.com/products/q-vd-oph.html","C26H25F2N3O6","free base","Quinoline-Val-Asp-Difluorophenoxymethylketone","CC(C)C(NC(=O)C1=NC2=CC=CC=C2C=C1)C(=O)NC(CC(O)=O)C(=O)COC3=C(F)C=CC=C3F",3.397,6,2,11]
["S7312","Z-DEVD-FMK","c8","L6200-17","in 10mM DMSO","Caspase","Apoptosis","Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.",668.66,"210344-95-9",{"v":100,"d":"100.00"},149.55,"<1","N/A","http://selleckchem.com/products/z-devd-fmk.html","C30H41FN4O12","free base","Caspase-3 Inhibitor","COC(=O)CCC(CC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF",1.347,12,3,24]
["S7315","PFI-3","d8","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-3 is a selective chemical probe for SMARCA bromodomains, including SMARCA2, SMARCA4 and PB1(5) bromodomains.",321.37,"1819363-80-8",{"v":64,"d":"64.00"},199.15,"<1","N/A","http://selleckchem.com/products/pfi-3.html","C19H19N3O2","free base","N/A","OC1=CC=CC=C1C(=O)\\C=C\\N2CC3CC2CN3C4=NC=CC=C4",2.438,2,1,4]
["S7317","WZ4003","e8","L6200-17","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 in cell-base assays, respectively, without significant inhibition on 139 other kinases.",496.99,"1214265-58-3",{"v":7,"d":"7.00"},14.08,"<1","N/A","http://selleckchem.com/products/wz4003.html","C25H29ClN6O3","free base","N/A","CCC(=O)NC1=CC=CC(=C1)OC2=NC(=NC=C2Cl)NC3=C(OC)C=C(C=C3)N4CCN(C)CC4",4.776,5,2,8]
["S7318","HTH-01-015","f8","L6200-17","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.",468.55,"1613724-42-7",{"v":58,"d":"58.00"},123.79,"<1","N/A","http://selleckchem.com/products/hth-01-015.html","C26H28N8O","free base","N/A","CN1C(=O)C2=C(C=C3C=CC=CC3=C2)N(C)C4=NC(=NC(=C14)C)NC5=C[N](N=C5)C6CCNCC6",2.993,4,2,3]
["S7323","Itanapraced (CHF 5074)","g8","L6200-17","in 10mM DMSO","Secretase,Secretase","Proteases","Itanapraced (CHF 5074, CSP-1103) is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L.",325.16,"749269-83-8",{"v":65,"d":"65.00"},{"v":199.9,"d":"199.90"},"<1","N/A","http://www.selleckchem.com/products/chf-5074.html","C16H11Cl2FO2","Free Base","CSP-1103","OC(=O)C1(CC1)C2=CC(=C(C=C2)C3=CC=C(Cl)C(=C3)Cl)F",5.055,1,0,3]
["S7324","TMP269","h8","L6200-17","in 10mM DMSO","HDAC","Epigenetics","TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.",514.52,"1314890-29-3",{"v":100,"d":"100.00"},194.36,"<1","N/A","http://selleckchem.com/products/tmp269.html","C25H21F3N4O3S","free base","N/A","FC(F)(F)C1=NC(=NO1)C2=CC=CC(=C2)C(=O)NCC3(CCOCC3)C4=NC(=CS4)C5=CC=CC=C5",4.311,6,1,7]
["S7327","ID-8","a9","L6200-17","in 10mM DMSO","DYRK","Cell Cycle","ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.",298.29,"147591-46-6",{"v":60,"d":"60.00"},201.15,"<1","N/A","http://selleckchem.com/products/id-8.html","C16H14N2O4","free base","N/A","COC1=CC=C(C=C1)[N]2C(=C(C3=C2C=C(O)C=C3)[N+]([O-])=O)C",3.687,1,1,3]
["S7334","ERK5-IN-1","b9","L6200-17","in 10mM DMSO","ERK","MAPK","ERK5-IN-1 (XMD17-109) is a potent, and selective ERK5 inhibitor with IC50 of 162 nM.",638.81,"1435488-37-1",{"v":100,"d":"100.00"},156.54,"<1","N/A","http://selleckchem.com/products/erk5-in-1.html","C36H46N8O3","free base","XMD17-109","CCOC1=C(NC2=NC=C3N(C)C(=O)C4=C(C=CC=C4)N(C5CCCC5)C3=N2)C=CC(=C1)C(=O)N6CCC(CC6)N7CCN(C)CC7",4.794,5,1,7]
["S7335","IPI-3063","c9","L6200-17","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.",455.51,"1425043-73-7",{"v":91,"d":"91.00"},199.78,"<1","N/A","http://selleckchem.com/products/ipi-3063.html","C25H25N7O2","free base","N/A","CC(C)N1C(=O)C2=C(C=CC=C2C=C1C(C)NC3=C(C#N)C(=NC=N3)N)C4=CN(C)C(=O)C=C4",1.621,4,2,5]
["S7336","CW069","d9","L6200-17","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP.",500.33,"1594094-64-0",{"v":100,"d":"100.00"},199.87,"<1","N/A","http://selleckchem.com/products/cw069.html","C23H21IN2O3","free base","N/A","OC(=O)C1=CC(=CC=C1NC(=O)C(CC2=CC=CC=C2)NCC3=CC=CC=C3)I",1.547,2,2,8]
["S7337","SH-4-54","e9","L6200-17","in 10mM DMSO","STAT","JAK/STAT","SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.",610.59,"1456632-40-8",{"v":100,"d":"100.00"},163.78,"<1","N/A","http://selleckchem.com/products/sh-4-54.html","C29H27F5N2O5S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(O)=O)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",6.221,4,0,9]
["S7340","CH5138303","f9","L6200-17","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.",{"v":415.9,"d":"415.90"},"959763-06-5",{"v":83,"d":"83.00"},199.57,"<1","N/A","http://selleckchem.com/products/ch5138303.html","C19H18ClN5O2S","free base","N/A","NC(=O)CCCSC1=NC(=NC(=N1)C2=C(Cl)C=C3COCC4=CC=CC2=C34)N",2.956,5,2,6]
["S7343","URMC-099","g9","L6200-17","in 10mM DMSO","Autophagy,Bcr-Abl,LRRK2,Mixed Lineage Kinase","MAPK","URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM. URMC-099 also inhibits ABL1 with IC50 of 6.8 nM. URMC-099 induces autophagy.",421.54,"1229582-33-5",{"v":84,"d":"84.00"},199.27,"<1","N/A","http://selleckchem.com/products/urmc-099.html","C27H27N5","free base","N/A","CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C([NH]C=C4C5=CC=C6[NH]C=CC6=C5)N=C3",4.533,1,2,4]
["S7351","JSH-23","h9","L6200-17","in 10mM DMSO","NF-κB","NF-κB","JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.",240.34,"749886-87-1",{"v":48,"d":"48.00"},199.72,"<1","N/A","http://selleckchem.com/products/jsh-23.html","C16H20N2","free base","N/A","CC1=CC=C(NCCCC2=CC=CC=C2)C(=C1)N",3.739,0,2,5]
["S7352","Bay 11-7085","a10","L6200-17","in 10mM DMSO","IκB/IKK","NF-κB","BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.",249.33,"196309-76-9",{"v":50,"d":"50.00"},200.54,"<1","N/A","http://selleckchem.com/products/bay-11-7085.html","C13H15NO2S","free base","Bay 11-7083","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",2.635,2,0,3]
["S7353","EPZ004777","b10","L6200-17","in 10mM DMSO","Apoptosis related,DOT1,Histone Methyltransferase","Epigenetics","EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis.",539.67,"1338466-77-5",{"v":100,"d":"100.00"},{"v":185.3,"d":"185.30"},"<1","N/A","http://selleckchem.com/products/epz004777.html","C28H41N7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=CC4=C3N=CN=C4N",2.529,4,5,10]
["S7356","HS-173","c10","L6200-17","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM.",422.46,"1276110-06-5",{"v":84,"d":"84.00"},198.84,"<1","N/A","http://selleckchem.com/products/hs-173.html","C21H18N4O4S","free base","N/A","CCOC(=O)C1=CN=C2C=CC(=C[N]12)C3=CN=CC(=C3)N[S](=O)(=O)C4=CC=CC=C4",2.058,6,1,7]
["S7359","K02288","d10","L6200-17","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.",352.38,"1431985-92-0",{"v":70,"d":"70.00"},198.65,"<1","N/A","http://selleckchem.com/products/k02288.html","C20H20N2O4","free base","N/A","COC1=CC(=CC(=C1OC)OC)C2=C(N)N=CC(=C2)C3=CC=CC(=C3)O",3.217,4,2,5]
["S7360","Birabresib (OTX015)","e10","L6200-17","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",491.99,"202590-98-5",{"v":98,"d":"98.00"},199.19,"<1","N/A","http://selleckchem.com/products/otx015.html","C25H22ClN5O2S","free base","MK 8628","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(O)C=C4)N=C2C5=CC=C(Cl)C=C5)C",4.709,4,2,4]
["S7363","BRD7552","f10","L6200-17","in 10mM DMSO","Others","Others","BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.",711.63,"1137359-47-7",{"v":100,"d":"100.00"},140.52,"<1","N/A","http://selleckchem.com/products/brd7552.html","C33H33N3O15","free base","N/A","CCOC(=O)C1=CC=C(NC(=O)OC2C(CO)OC(OC)C(OC(=O)NC3=CC=C4OCOC4=C3)C2OC(=O)NC5=CC=C6OCOC6=C5)C=C1",{"v":3.49,"d":"3.490"},14,4,14]
["S7364","Atglistatin","g10","L6200-17","in 10mM DMSO","Lipase","Metabolism","Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.",283.37,"1469924-27-3",{"v":56,"d":"56.00"},197.62,"<1","N/A","http://selleckchem.com/products/atglistatin.html","C17H21N3O","free base","N/A","CN(C)C(=O)NC1=CC=CC(=C1)C2=CC=C(C=C2)N(C)C",2.832,1,1,3]
["S7369","4EGI-1","h10","L6200-17","in 10mM DMSO","Apoptosis related,eIF,mTOR","Cell Cycle","4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.",451.28,"315706-13-9",{"v":90,"d":"90.00"},199.43,"<1","N/A","http://selleckchem.com/products/4egi-1.html","C18H12Cl2N4O4S","free base","N/A","OC(=O)C(/CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(=CS2)C3=CC=C(Cl)C(=C3)Cl",5.397,3,1,7]
["S7370","4E1RCat","a11","L6200-17","in 10mM DMSO","eIF","Cell Cycle","4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.",478.45,"328998-25-0",{"v":96,"d":"96.00"},200.65,"<1","N/A","http://selleckchem.com/products/4e1rcat.html","C28H18N2O6","free base","N/A","OC(=O)C1=CC=C(C=C1)N2C(=O)\\C(=C\\C3=CC=C(O3)C4=CC=C(C=C4)[N+]([O-])=O)C=C2C5=CC=CC=C5",5.414,3,0,6]
["S7373","UNC669","b11","L6200-17","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4.",338.24,"1314241-44-5",{"v":11,"d":"11.00"},32.52,"<1","N/A","http://selleckchem.com/products/unc669.html","C15H20BrN3O","free base","N/A","BrC1=CN=CC(=C1)C(=O)N2CCC(CC2)N3CCCC3",1.413,2,0,2]
["S7378","AEBSF HCl","c11","L6200-17","in 10mM DMSO","Serine Protease","Proteases","AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.",239.69,"30827-99-7",{"v":47,"d":"47.00"},196.09,{"v":20,"d":"20.00"},83.44,"http://selleckchem.com/products/aebsf-hcl.html","C8H11ClFNO2S","Hydrochloride","N/A","Cl.NCCC1=CC=C(C=C1)[S](F)(=O)=O",1.261,2,1,3]
["S7379","E-64","d11","L6200-17","in 10mM DMSO","Apoptosis related,Cathepsin B,Cysteine Protease,Parasite","Proteases","E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. E-64 induces oxidative stress and apoptosis in Filarial Parasite.",357.41,"66701-25-5",{"v":71,"d":"71.00"},198.65,{"v":11,"d":"11.00"},30.78,"http://selleckchem.com/products/e-64.html","C15H27N5O5","free base","N/A","CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCNC(N)=N",-0.864,4,4,12]
["S7380","Leupeptin Hemisulfate","e11","L6200-17","in 10mM DMSO","Cathepsin B,Cysteine Protease,Serine Protease","Proteases","Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.",475.59,"103476-89-7",{"v":95,"d":"95.00"},199.75,{"v":95,"d":"95.00"},199.75,"http://selleckchem.com/products/leupeptin-hemisulfate.html","C20H38N6O4.1/2H2SO4","sulfate","N/A","CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O",0.977,4,5,15]
["S7381","Pepstatin A","f11","L6200-17","in 10mM DMSO","Autophagy,Cysteine Protease,HIV Protease","Proteases","Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.",685.89,"26305-03-3",{"v":57,"d":"57.00"},{"v":83.1,"d":"83.10"},"<1","N/A","http://selleckchem.com/products/pepstatin-a.html","C34H63N5O9","free base","Pepstatin","CC(C)CC(NC(=O)C(C)NC(=O)CC(O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)C(O)CC(O)=O",2.301,6,7,22]
["S7386","MG-101 (ALLN)","g11","L6200-17","in 10mM DMSO","Cysteine Protease","Proteases","MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.",383.53,"110044-82-1",{"v":76,"d":"76.00"},198.16,"<1","N/A","http://selleckchem.com/products/mg-101-alln.html","C20H37N3O4","Oxalate","Calpain inhibitor-1, Ac-LLnL-CHO","CCCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O",2.348,4,3,13]
["S7391","Z-FA-FMK","h11","L6200-17","in 10mM DMSO","Cysteine Protease","Proteases","Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.",386.42,"197855-65-5",{"v":77,"d":"77.00"},199.27,"<1","N/A","http://selleckchem.com/products/z-fa-fmk.html","C21H23FN2O4","free base","(1S)-Z-FA-FMK","CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2)C(=O)CF",3.034,4,2,10]
["S7392","Loxistatin Acid (E-64C)","a2","L6200-18","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Loxistatin Acid (E-64C, NSC 694279, EP 475), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry.",314.38,"76684-89-4",{"v":62,"d":"62.00"},197.21,{"v":2,"d":"2.00"},6.36,"http://selleckchem.com/products/loxistatin-acid-e-64c.html","C15H26N2O5","free base","NSC 694279, EP 475","CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(O)=O",1.037,4,2,9]
["S7393","Aloxistatin (E64d)","b2","L6200-18","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.",342.43,"88321-09-9",{"v":68,"d":"68.00"},198.58,"<1","N/A","http://selleckchem.com/products/Aloxistatin.html","C17H30N2O5","free base","E-64d","CCOC(=O)C1OC1C(=O)NC(CC(C)C)C(=O)NCCC(C)C",1.611,5,2,11]
["S7396","Calpeptin","c2","L6200-18","in 10mM DMSO","Apoptosis related,Cysteine Protease","Proteases","Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.",362.46,"117591-20-5",{"v":72,"d":"72.00"},198.64,"<1","N/A","http://selleckchem.com/products/calpeptin.html","C20H30N2O4","free base","N/A","CCCCC(NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",{"v":3.8,"d":"3.800"},4,2,12]
["S7397","Sorafenib (BAY 43-9006)","d2","L6200-18","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,FLT3,PDGFR,Raf,VEGFR","MAPK","Sorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.",464.82,"284461-73-0",{"v":63,"d":"63.00"},135.54,"<1","N/A","http://selleckchem.com/products/sorafenib.html","C21H16ClF3N4O3","Free Base","NSC-724772,BAY 43-9006","CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2",4.175,4,3,6]
["S7399","FLI-06","e2","L6200-18","in 10mM DMSO","Notch","Stem Cells & Wnt","FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.",438.52,"313967-18-9",{"v":88,"d":"88.00"},200.67,"<1","N/A","http://selleckchem.com/products/fli-06.html","C25H30N2O5","free base","N/A","CC1=C(C(C2=CC=C(C=C2)[N+]([O-])=O)C3=C(CC(C)(C)CC3=O)N1)C(=O)OC4CCCCC4",{"v":4.32,"d":"4.320"},3,1,5]
["S7409","Anisomycin","f2","L6200-18","in 10mM DMSO","Apoptosis related,Autophagy,JNK","MAPK","Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.",{"v":265.3,"d":"265.30"},"22862-76-6",{"v":41,"d":"41.00"},154.54,"<1","N/A","http://selleckchem.com/products/anisomycin.html","C14H19NO4","free base","Flagecidin, Wuningmeisu C","COC1=CC=C(CC2NCC(O)C2OC(C)=O)C=C1",0.877,3,2,5]
["S7414","Caffeic Acid Phenethyl Ester","g2","L6200-18","in 10mM DMSO","NF-κB","NF-κB","Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.",284.31,"104594-70-9",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/caffeic-acid-phenethyl-ester.html","C17H16O4","free base","CAPE, Phenylethyl Caffeate","OC1=CC=C(/C=C/C(=O)OCCC2=CC=CC=C2)C=C1O",3.573,2,2,6]
["S7420","CA-074 methyl ester (CA-074 Me)","h2","L6200-18","in 10mM DMSO","Cathepsin B,Cysteine Protease","Proteases","CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.",397.47,"147859-80-1",{"v":79,"d":"79.00"},198.76,{"v":79,"d":"79.00"},198.76,"http://selleckchem.com/products/ca-074-methyl-ester.html","C19H31N3O6","free base","Cathepsin B Inhibitor IV","CCCNC(=O)C1OC1C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC",0.484,6,2,10]
["S7424","PD 151746","a3","L6200-18","in 10mM DMSO","Cysteine Protease","Proteases","PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.",237.25,"179461-52-0",{"v":47,"d":"47.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pd-151746.html","C11H8FNO2S","free base","N/A","OC(=O)C(/S)=C/C1=C[NH]C2=CC=C(F)C=C12",{"v":2.49,"d":"2.490"},1,1,2]
["S7429","MI-2 (MALT1 inhibitor)","b3","L6200-18","in 10mM DMSO","MALT","Immunology & Inflammation","MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.",455.72,"1047953-91-2",{"v":91,"d":"91.00"},199.68,"<1","N/A","http://selleckchem.com/products/mi-2-malt1-inhibitor.html","C19H17Cl3N4O3","free base","N/A","COCCOC1=N[N](C2=CC=C(NC(=O)CCl)C=C2)C(=N1)C3=CC(=C(Cl)C=C3)Cl",4.653,5,1,8]
["S7430","SB-3CT","c3","L6200-18","in 10mM DMSO","MMP","Proteases","SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.",{"v":306.4,"d":"306.40"},"292605-14-2",{"v":61,"d":"61.00"},199.09,"<1","N/A","http://selleckchem.com/products/sb-3ct.html","C15H14O3S2","free base","N/A","O=[S](=O)(CC1CS1)C2=CC=C(OC3=CC=CC=C3)C=C2",3.377,3,0,5]
["S7434","TAPI-1","d3","L6200-18","in 10mM DMSO","Immunology & Inflammation related,MMP","Immunology & Inflammation","TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).",{"v":499.6,"d":"499.60"},"171235-71-5",{"v":99,"d":"99.00"},198.16,{"v":60,"d":"60.00"},{"v":120.1,"d":"120.10"},"http://selleckchem.com/products/tapi-1.html","C26H37N5O5","free base","N/A","CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN",0.954,4,5,13]
["S7435","AR-A014418","e3","L6200-18","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.",308.31,"487021-52-3",{"v":61,"d":"61.00"},197.85,"<1","N/A","http://selleckchem.com/products/A014418.html","C12H12N4O4S","free base","GSK-3β Inhibitor VIII","COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1",1.529,3,2,5]
["S7438","ME0328","f3","L6200-18","in 10mM DMSO","PARP","DNA Damage/DNA Repair","ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.",321.37,"1445251-22-8",{"v":64,"d":"64.00"},199.15,"<1","N/A","http://selleckchem.com/products/me0328.html","C19H19N3O2","free base","N/A","CC(NC(=O)CCC1=NC2=CC=CC=C2C(=O)N1)C3=CC=CC=C3",2.213,3,2,5]
["S7440","Ribociclib (LEE011)","g3","L6200-18","in 10mM DMSO","CDK","Cell Cycle","Ribociclib (LEE011) is an orally available, and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM. Phase 3.",434.54,"1211441-98-3",{"v":7,"d":"7.00"},16.11,"<1","N/A","http://selleckchem.com/products/lee011.html","C23H30N8O","free base","N/A","CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2[N]1C5CCCC5",{"v":2.9,"d":"2.900"},4,2,5]
["S7441","WS3","h3","L6200-18","in 10mM DMSO","IκB/IKK","NF-κB","WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.",569.58,"1421227-52-2",{"v":100,"d":"100.00"},175.57,"<1","N/A","http://selleckchem.com/products/ws3.html","C28H30F3N7O3","free base","N/A","CN1CCN(CC1)CC2=C(C=C(NC(=O)NC3=CC=C(OC4=CC(=NC=N4)NC(=O)C5CC5)C=C3)C=C2)C(F)(F)F",4.234,5,3,9]
["S7442","WS6","a4","L6200-18","in 10mM DMSO","IκB/IKK","NF-κB","WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.",568.59,"1421227-53-3",{"v":100,"d":"100.00"},175.87,"<1","N/A","http://selleckchem.com/products/ws6.html","C29H31F3N6O3","free base","N/A","CN1CCN(CC1)CC2=C(C=C(NC(=O)CC3=CC=C(OC4=CC(=NC=N4)NC(=O)C5CC5)C=C3)C=C2)C(F)(F)F",{"v":4.36,"d":"4.360"},5,2,10]
["S7444","Pyridostatin (RR82) Trifluoroacetate Salt","b4","L6200-18","in 10mM DMSO","G-quadruplex","DNA Damage/DNA Repair","Pyridostatin Trifluoroacetate Salt (RR82) is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.",{"v":710.7,"d":"710.70"},"1472611-44-1",{"v":100,"d":"100.00"},167.61,{"v":100,"d":"100.00"},167.61,"http://selleckchem.com/products/pyridostatin-trifluoroacetate-salt.html","C31H32N8O5.C2HF3O2","trifluoroacetat","N/A","NCCOC1=CC(=NC(=C1)C(=O)NC2=NC3=C(C=CC=C3)C(=C2)OCCN)C(=O)NC4=CC(=C5C=CC=CC5=N4)OCCN.OC(=O)C(F)(F)F",0.425,9,5,14]
["S7445","APX-3330","c4","L6200-18","in 10mM DMSO","DNA/RNA Synthesis,NF-κB","DNA Damage/DNA Repair","APX-3330 (E3330) is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.",378.46,"136164-66-4",{"v":75,"d":"75.00"},198.17,"<1","N/A","http://selleckchem.com/products/e3330.html","C21H30O6","free base","E3330","CCCCCCCCCC(=C/C1=C(C)C(=O)C(=C(OC)C1=O)OC)\\C(O)=O",4.663,5,0,12]
["S7448","CORM-3","d4","L6200-18","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.",294.61,"475473-26-8",{"v":38,"d":"38.00"},128.98,"<1","N/A","http://selleckchem.com/products/corm-3.html","C5H4ClNO5Ru","free base","N/A","Cl[Ru]1(NCC(=O)O1)(C=O)(C=O)C=O",-0.104,5,1,3]
["S7449","CRT0044876","e4","L6200-18","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","CRT0044876 (NSC 69877, 7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.",206.15,"6960-45-8",{"v":41,"d":"41.00"},198.88,"<1","N/A","http://selleckchem.com/products/crt0044876.html","C9H6N2O4","free base","NSC 69877,7-NO2-ICA","OC(=O)C1=CC2=C([NH]1)C(=CC=C2)[N+]([O-])=O",1.939,1,1,2]
["S7457","XEN445","f4","L6200-18","in 10mM DMSO","Lipase","Metabolism","XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.",366.33,"1515856-92-4",{"v":80,"d":"80.00"},218.38,"<1","N/A","http://selleckchem.com/products/xen445.html","C18H17F3N2O3","free base","N/A","OC(=O)C1=CC(=CC=C1N2CCC(C2)OCC3=NC=CC=C3)C(F)(F)F",3.725,3,0,6]
["S7458","VER-49009","g4","L6200-18","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-49009 (CCT0129397) is a potent HSP90 inhibitor with IC50 of 47 nM for HSP90β.",387.82,"940289-57-6",{"v":77,"d":"77.00"},198.55,"<1","N/A","http://selleckchem.com/products/ver-49009.html","C19H18ClN3O4","free base","CCT0129397","CCNC(=O)C1=C(C2=CC=C(OC)C=C2)C(=N[NH]1)C3=CC(=C(O)C=C3O)Cl",3.751,3,4,5]
["S7459","VER-50589","h4","L6200-18","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β.",{"v":388.8,"d":"388.80"},"747413-08-7",{"v":77,"d":"77.00"},198.05,"<1","N/A","http://selleckchem.com/products/ver-50589.html","C19H17ClN2O5","free base","N/A","CCNC(=O)C1=NOC(=C1C2=CC=C(OC)C=C2)C3=CC(=C(O)C=C3O)Cl",3.761,4,3,5]
["S7460","BTB06584","a5","L6200-18","in 10mM DMSO","ATPase","Transmembrane Transporters","BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.",417.82,"219793-45-0",{"v":84,"d":"84.00"},201.04,"<1","N/A","http://selleckchem.com/products/btb06584.html","C19H12ClNO6S","free base","N/A","[O-][N+](=O)C1=CC=C(C=C1OC(=O)C2=CC=C(Cl)C=C2)[S](=O)(=O)C3=CC=CC=C3",4.923,4,0,6]
["S7461","LDC000067","b5","L6200-18","in 10mM DMSO","CDK","Cell Cycle","LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.",370.43,"1073485-20-7",{"v":74,"d":"74.00"},199.77,"<1","N/A","http://selleckchem.com/products/ldc000067.html","C18H18N4O3S","free base","LDC067","COC1=CC=CC=C1C2=NC=NC(=C2)NC3=CC(=CC=C3)C[S](N)(=O)=O",2.783,5,2,6]
["S7462","PI-1840","c5","L6200-18","in 10mM DMSO","Proteasome","Proteases","PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).",394.47,"1401223-22-0",{"v":78,"d":"78.00"},197.73,"<1","N/A","http://selleckchem.com/products/pi-1840.html","C22H26N4O3","free base","N/A","CCCC1=CC=C(OCC(=O)N(CC2=NC(=NO2)C3=CC=CN=C3)C(C)C)C=C1",{"v":3.22,"d":"3.220"},6,0,9]
["S7470","Triapine","d5","L6200-18","in 10mM DMSO","DNA/RNA Synthesis,RNR","DNA Damage/DNA Repair","Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.",195.24,"200933-27-3",{"v":20,"d":"20.00"},102.44,"<1","N/A","http://selleckchem.com/products/triapine.html","C7H9N5S","free base","3-AP","NC(=S)N/N=C/C1=NC=CC=C1N",0.331,2,3,3]
["S7473","Nexturastat A","e5","L6200-18","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.",{"v":341.4,"d":"341.40"},"1403783-31-2",{"v":68,"d":"68.00"},199.18,"<1","N/A","http://selleckchem.com/products/nexturastat-a.html","C19H23N3O3","free base","N/A","CCCCN(CC1=CC=C(C=C1)C(=O)NO)C(=O)NC2=CC=CC=C2",3.079,2,2,7]
["S7476","MG149","f5","L6200-18","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.",340.46,"1243583-85-8",{"v":68,"d":"68.00"},199.73,"<1","N/A","http://selleckchem.com/products/mg149.html","C22H28O3","free base","Tip60 HAT inhibitor","CCCCCCCC1=CC=C(CCC2=C(C(O)=O)C(=CC=C2)O)C=C1",6.872,1,1,10]
["S7483","DMOG","g5","L6200-18","in 10mM DMSO","Autophagy,HIF,Hydroxylase","Metabolism","DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.",175.14,"89464-63-1",{"v":35,"d":"35.00"},199.84,{"v":35,"d":"35.00"},199.84,"http://selleckchem.com/products/dmog.html","C6H9NO5","free base","Dimethyloxalylglycine","COC(=O)CNC(=O)C(=O)OC",-0.918,5,1,5]
["S7484","FH535","h5","L6200-18","in 10mM DMSO","PPAR,Wnt/beta-catenin","Stem Cells & Wnt","FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.",{"v":361.2,"d":"361.20"},"108409-83-2",{"v":72,"d":"72.00"},199.34,"<1","N/A","http://selleckchem.com/products/fh535.html","C13H10Cl2N2O4S","free base","N/A","CC1=C(N[S](=O)(=O)C2=C(Cl)C=CC(=C2)Cl)C=CC(=C1)[N+]([O-])=O",4.027,2,1,4]
["S7488","MPI-0479605","a6","L6200-18","in 10mM DMSO","MPS1","Cell Cycle","MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.",407.51,"1246529-32-7",{"v":62,"d":"62.00"},152.14,"<1","N/A","http://selleckchem.com/products/mpi-0479605.html","C22H29N7O","free base","N/A","CC1=CC(=CC=C1NC2=NC3=C(N=C[NH]3)C(=N2)NC4CCCCC4)N5CCOCC5",4.379,4,3,5]
["S7489","YH239-EE","b6","L6200-18","in 10mM DMSO","MDM2/MDMX","Apoptosis","YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.",504.41,"1364488-67-4",{"v":100,"d":"100.00"},198.25,"<1","N/A","http://selleckchem.com/products/yh239-ee.html","C25H27Cl2N3O4","free base","N/A","CCOC(=O)C1=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(=O)NC(C)(C)C)C3=C([NH]1)C=C(Cl)C=C3",4.912,4,2,9]
["S7490","WIKI4","c6","L6200-18","in 10mM DMSO","PARP,Wnt/beta-catenin","DNA Damage/DNA Repair","WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.",521.59,"838818-26-1",{"v":7,"d":"7.00"},13.42,"<1","N/A","http://selleckchem.com/products/wiki4.html","C29H23N5O3S","free base","N/A","COC1=CC=C(C=C1)[N]2C(=NN=C2C3=CC=NC=C3)SCCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O",4.469,6,0,8]
["S7492","Uprosertib (GSK2141795)","d6","L6200-18","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Uprosertib (GSK2141795, GSK795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.",429.25,"1047634-65-0",{"v":85,"d":"85.00"},198.02,"<1","N/A","http://selleckchem.com/products/gsk2141795.html","C18H16Cl2F2N4O2","free base","GSK795","C[N]1N=CC(=C1C2=C(Cl)OC(=C2)C(=O)NC(CN)CC3=CC(=C(F)C=C3)F)Cl",3.531,3,2,6]
["S7501","HO-3867","e6","L6200-18","in 10mM DMSO","Apoptosis related,STAT","JAK/STAT","HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.",464.55,"1172133-28-6",{"v":13,"d":"13.00"},27.98,"<1","N/A","http://selleckchem.com/products/ho-3867.html","C28H30F2N2O2","free base","N/A","CC1(C)C=C(CN2C\\C(=C/C3=CC=C(F)C=C3)C(=O)C(/C2)=C/C4=CC=C(F)C=C4)C(C)(C)N1O",5.209,1,0,4]
["S7505","(S)-crizotinib","f6","L6200-18","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.",450.34,"1374356-45-2",{"v":42,"d":"42.00"},93.26,"<1","N/A","http://selleckchem.com/products/s-crizotinib.html","C21H22Cl2FN5O","free base","N/A","CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F",3.693,3,2,5]
["S7509","ML167","g6","L6200-18","in 10mM DMSO","CDK","Cell Cycle","ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.",335.36,"1285702-20-6",{"v":67,"d":"67.00"},199.79,"<1","N/A","http://selleckchem.com/products/ml167.html","C19H17N3O3","free base","CID 44968231","CC1=CC=C(CNC2=NC=NC3=CC=C(C=C23)C4=CC=C(CO)O4)O1",3.033,4,2,5]
["S7511","LY2857785","h6","L6200-18","in 10mM DMSO","CDK","Cell Cycle","LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9(IC50=0.011 μM) and also inhibits other transcription kinases CDK8(IC50=0.016 μM) and CDK7 (IC50=0.246 μM).",{"v":448.6,"d":"448.60"},"1619903-54-6",{"v":23,"d":"23.00"},51.27,"<1","N/A","http://selleckchem.com/products/ly2857785.html","C26H36N6O","free base","N/A","CC(C)C1=C2C=C(C=CC2=N[N]1C)C3=CC=NC(=N3)NC4CCC(CC4)NC5CCOCC5",4.194,4,2,6]
["S7513","Trelagliptin","a7","L6200-18","in 10mM DMSO","DPP","Proteases","Trelagliptin (SYR-472), a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM, improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).",357.38,"865759-25-7",{"v":71,"d":"71.00"},198.67,"<1","N/A","http://selleckchem.com/products/trelagliptin.html","C18H20FN5O2","free base","SYR-472","CN1C(=O)C=C(N2CCCC(N)C2)N(CC3=CC(=CC=C3C#N)F)C1=O",1.476,2,1,3]
["S7521","Afuresertib (GSK2110183)","b7","L6200-18","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.",427.32,"1047644-62-1",{"v":85,"d":"85.00"},198.91,"<1","N/A","http://selleckchem.com/products/afuresertib-gsk2110183.html","C18H17Cl2FN4OS","free base","N/A","C[N]1N=CC(=C1C2=C(Cl)SC(=C2)C(=O)NC(CN)CC3=CC=CC(=C3)F)Cl",3.884,2,2,6]
["S7524","FR 180204","c7","L6200-18","in 10mM DMSO","ERK","MAPK","FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK1, MKK4, IKKα, PKCα, Src, Syc, and PDGFα) at less than 30 μM.",327.34,"865362-74-9",{"v":65,"d":"65.00"},198.57,"<1","N/A","http://selleckchem.com/products/fr180204.html","C18H13N7","free base","N/A","NC1=N[NH]C2=C1C=C(N=N2)C3=C4C=CC=C[N]4N=C3C5=CC=CC=C5",2.969,4,2,2]
["S7525","XMD8-92","d7","L6200-18","in 10mM DMSO","Epigenetic Reader Domain,ERK","MAPK","XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with Kd of 80 nM and 170 nM for ERK5 and BRD4(1), respectively.",474.55,"1234480-50-2",{"v":73,"d":"73.00"},153.83,"<1","N/A","http://selleckchem.com/products/xmd8-92.html","C26H30N6O3","free base","N/A","CCOC1=CC(=CC=C1NC2=NC3=C(C=N2)N(C)C(=O)C4=C(C=CC=C4)N3C)N5CCC(O)CC5",3.505,4,2,5]
["S7529","ML323","e7","L6200-18","in 10mM DMSO","DUB","Ubiquitin","ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.",384.48,"1572414-83-5",{"v":76,"d":"76.00"},197.67,"<1","N/A","http://selleckchem.com/products/ml323.html","C23H24N6","free base","N/A","CC(C)C1=C(C=CC=C1)C2=NC(=C(C)C=N2)NCC3=CC=C(C=C3)[N]4C=CN=N4",5.042,4,1,6]
["S7530","Vactosertib (TEW-7197)","f7","L6200-18","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Vactosertib  (TEW-7197, EW-7197) is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1.",399.42,"1352608-82-2",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/ew-7197.html","C22H18FN7","free base","EW-7197","CC1=NC(=CC=C1)C2=C(N=C(CNC3=CC=CC=C3F)[NH]2)C4=C[N]5N=CN=C5C=C4",3.621,4,2,5]
["S7541","Decernotinib (VX-509)","g7","L6200-18","in 10mM DMSO","JAK","JAK/STAT","Decernotinib (VX-509) is a potent and selective JAK3 inhibitor with Ki of 2.5 nM, >4-fold selectivity over JAK1, JAK2, and TYK2, respectively. Phase 2/3.",392.38,"944842-54-0",{"v":78,"d":"78.00"},198.79,"<1","N/A","http://selleckchem.com/products/decernotinib-vx-509.html","C18H19F3N6O","free base","N/A","CCC(C)(NC1=NC(=NC=C1)C2=C[NH]C3=NC=CC=C23)C(=O)NCC(F)(F)F",2.747,4,3,7]
["S7546","Pritelivir (BAY 57-1293)","h7","L6200-18","in 10mM DMSO","DNA/RNA Synthesis,HSV","DNA Damage/DNA Repair","Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.",402.49,"348086-71-5",{"v":80,"d":"80.00"},198.76,"<1","N/A","http://selleckchem.com/products/bay-57-1293.html","C18H18N4O3S2","free base","AIC316","CN(C(=O)CC1=CC=C(C=C1)C2=NC=CC=C2)C3=NC(=C(S3)[S](N)(=O)=O)C",1.761,5,1,5]
["S7551","Piperlongumine","a8","L6200-18","in 10mM DMSO","CRM1,ROS","Immunology & Inflammation","Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.",317.34,"20069-09-4",{"v":16,"d":"16.00"},50.42,"<1","N/A","http://selleckchem.com/products/piperlongumine.html","C17H19NO5","free base","PPLGM, Piplartine","COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O",2.135,5,0,5]
["S7555","Domatinostat (4SC-202)","b8","L6200-18","in 10mM DMSO","HDAC","Epigenetics","Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.",447.51,"910462-43-0",{"v":89,"d":"89.00"},198.88,"<1","N/A","http://selleckchem.com/products/4sc-202.html","C23H21N5O3S","free base","N/A","C[N]1C=C(C=N1)C2=CC=C(C=C2)[S](=O)(=O)[N]3C=CC(=C3)\\C=C\\C(=O)NC4=CC=CC=C4N",2.955,4,2,6]
["S7563","AT13148","c8","L6200-18","in 10mM DMSO","Akt,PKA,ROCK,S6 Kinase","PI3K/Akt/mTOR","AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.",313.78,"1056901-62-2",{"v":62,"d":"62.00"},197.59,"<1","N/A","http://selleckchem.com/products/at13148.html","C17H16ClN3O","free base","N/A","NCC(O)(C1=CC=C(Cl)C=C1)C2=CC=C(C=C2)C3=C[NH]N=C3",2.491,1,2,4]
["S7566","IM-12","d8","L6200-18","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.",377.41,"1129669-05-1",{"v":75,"d":"75.00"},198.72,"<1","N/A","http://selleckchem.com/products/im-12.html","C22H20FN3O2","free base","N/A","CN1C(=O)C(=C(C1=O)C2=C(C)[NH]C3=C2C=CC=C3)NCCC4=CC=C(F)C=C4",3.074,2,2,5]
["S7569","LMK-235","e8","L6200-18","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.",294.35,"1418033-25-6",{"v":58,"d":"58.00"},197.04,"<1","N/A","http://selleckchem.com/products/lmk-235.html","C15H22N2O4","free base","N/A","CC1=CC(=CC(=C1)C(=O)NOCCCCCC(=O)NO)C",2.204,3,2,8]
["S7570","UNC0379","f8","L6200-18","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases.",413.56,"1620401-82-2",{"v":82,"d":"82.00"},198.28,"<1","N/A","http://selleckchem.com/products/unc0379.html","C23H35N5O2","free base","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCCC3)NCCCCCN4CCCC4",4.545,4,1,10]
["S7572","A-366","g8","L6200-18","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.",329.44,"1527503-11-2",{"v":65,"d":"65.00"},{"v":197.3,"d":"197.30"},"<1","N/A","http://selleckchem.com/products/a-366.html","C19H27N3O2","free base","N/A","COC1=C(OCCCN2CCCC2)C=C3N=C(N)C4(CCC4)C3=C1",2.467,3,1,6]
["S7574","GSK-LSD1 2HCl","h8","L6200-18","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).",289.24,"2102933-95-7",{"v":57,"d":"57.00"},197.07,{"v":57,"d":"57.00"},197.07,"http://selleckchem.com/products/gsk-lsd1-2hcl.html","C14H22Cl2N2","dihydrochloride","N/A","Cl.Cl.C1CC(CCN1)NC2CC2C3=CC=CC=C3",1.964,0,2,3]
["S7575","LLY-507","a9","L6200-18","in 10mM DMSO","Histone Methyltransferase,SMYD","Epigenetics","LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.",574.76,"1793053-37-8",{"v":100,"d":"100.00"},173.99,"<1","N/A","http://selleckchem.com/products/lly-507.html","C36H42N6O","free base","N/A","CC1=C[N](CCN2CCN(CC2)C3=CC=CC=C3C4=CC(=CC(=C4)C(=O)NCCCN5CCCC5)C#N)C6=C1C=CC=C6",5.851,1,1,10]
["S7577","AGK2","b9","L6200-18","in 10mM DMSO","Sirtuin","Cytoskeletal Signaling","AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.",434.27,"304896-28-4",{"v":10,"d":"10.00"},23.03,"<1","N/A","http://selleckchem.com/products/agk2.html","C23H13Cl2N3O2","free base","N/A","ClC1=CC=C(Cl)C(=C1)C2=CC=C(O2)\\C=C(C#N)/C(=O)NC3=C4C=CC=NC4=CC=C3",5.641,3,1,4]
["S7579","Ledipasvir (GS5885)","c9","L6200-18","in 10mM DMSO","COVID-19,HCV Protease","Microbiology","Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.",{"v":889,"d":"889.00"},"1256388-51-8",{"v":100,"d":"100.00"},112.49,"<1","N/A","http://selleckchem.com/products/ledipasvir-gs5885.html","C49H54F2N8O6","free base","N/A","COC(=O)NC(C(C)C)C(=O)N1C2CCC(C2)C1C3=NC4=CC=C(C=C4[NH]3)C5=CC=C6C7=CC=C(C=C7C(F)(F)C6=C5)C8=CN=C([NH]8)C9CCC%10(CC%10)N9C(=O)C(NC(=O)OC)C(C)C",7.304,8,4,12]
["S7581","GSK J1","d9","L6200-18","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM  in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.",389.45,"1373422-53-7",{"v":77,"d":"77.00"},197.71,"<1","N/A","http://selleckchem.com/products/gsk-j1.html","C22H23N5O2","free base","N/A","OC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",3.707,4,1,6]
["S7582","Anacardic Acid","e9","L6200-18","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,\n\nprostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.",348.52,"16611-84-0",{"v":69,"d":"69.00"},197.98,"<1","N/A","http://selleckchem.com/products/anacardic-acid.html","C22H36O3","free base","6-pentadecylsalicylic Acid","CCCCCCCCCCCCCCCC1=CC=CC(=C1C(O)=O)O",{"v":8.09,"d":"8.090"},1,1,15]
["S7588","Reversine","f9","L6200-18","in 10mM DMSO","Adenosine Receptor,Aurora Kinase","GPCR & G Protein","Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation.",393.23,"656820-32-5",{"v":5,"d":"5.00"},12.72,"<1","N/A","http://selleckchem.com/products/reversine.html","C21H27N7O","free base","N/A","C1CCC(CC1)NC2=C3N=C[NH]C3=NC(=N2)NC4=CC=C(C=C4)N5CCOCC5",3.893,4,3,5]
["S7591","BRD4770","g9","L6200-18","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.",413.47,"1374601-40-7",{"v":27,"d":"27.00"},{"v":65.3,"d":"65.30"},"<1","N/A","http://selleckchem.com/products/brd4770.html","C25H23N3O3","free base","N/A","COC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4",5.094,4,1,8]
["S7593","Splitomicin","h9","L6200-18","in 10mM DMSO","HDAC","Epigenetics","Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.",198.22,"5690-03-9",{"v":39,"d":"39.00"},196.75,"<1","N/A","http://selleckchem.com/products/splitomicin.html","C13H10O2","free base","N/A","O=C1CCC2=C3C=CC=CC3=CC=C2O1",2.831,2,0,0]
["S7595","Santacruzamate A (CAY10683)","a10","L6200-18","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.",278.35,"1477949-42-0",{"v":55,"d":"55.00"},197.59,"<1","N/A","http://selleckchem.com/products/santacruzamate-a-cay10683.html","C15H22N2O3","free base","N/A","CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1",1.899,3,2,9]
["S7596","CAY10603","b10","L6200-18","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.",{"v":446.5,"d":"446.50"},"1045792-66-2",{"v":89,"d":"89.00"},199.33,"<1","N/A","http://selleckchem.com/products/cay10603.html","C22H30N4O6","free base","BML-281","CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO",{"v":3.23,"d":"3.230"},6,3,12]
["S7605","Filgotinib (GLPG0634)","c10","L6200-18","in 10mM DMSO","JAK","JAK/STAT","Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Phase 2.",{"v":425.5,"d":"425.50"},"1206161-97-8",{"v":85,"d":"85.00"},199.76,"<1","N/A","http://selleckchem.com/products/filgotinib.html","C21H23N5O3S","free base","N/A","O=C(NC1=N[N]2C(=N1)C=CC=C2C3=CC=C(CN4CC[S](=O)(=O)CC4)C=C3)C5CC5",2.461,5,1,5]
["S7611","EI1","d10","L6200-18","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.",390.48,"1418308-27-6",{"v":42,"d":"42.00"},107.56,"<1","N/A","http://selleckchem.com/products/ei1.html","C23H26N4O2","free base","N/A","CCC(CC)[N]1C=CC2=C(C=C(C=C12)C#N)C(=O)NCC3=C(C)C=C(C)NC3=O",{"v":3.54,"d":"3.540"},2,2,6]
["S7612","PX-478 2HCl","e10","L6200-18","in 10mM DMSO","Apoptosis related,HIF","Angiogenesis","PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.",394.12,"685898-44-6",{"v":78,"d":"78.00"},197.91,{"v":78,"d":"78.00"},197.91,"http://selleckchem.com/products/px-478-2hcl.html","C13H20Cl4N2O3","dihydrochloride","N/A","Cl.Cl.NC(CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O",-0.251,1,1,8]
["S7616","CPI-169","f10","L6200-18","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.",528.66,"1450655-76-1",{"v":100,"d":"100.00"},189.16,"<1","N/A","http://selleckchem.com/products/cpi-169.html","C27H36N4O5S","free base","N/A","CC[S](=O)(=O)N1CCC(CC1)C(C)[N]2C(=C(C(=O)NCC3=C(OC)C=C(C)NC3=O)C4=CC=CC=C24)C",{"v":1.74,"d":"1.740"},5,2,8]
["S7617","Tasquinimod","g10","L6200-18","in 10mM DMSO","HDAC","Angiogenesis","Tasquinimod (ABR-215050) is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Phase 3.",406.36,"254964-60-8",{"v":81,"d":"81.00"},199.33,"<1","N/A","http://selleckchem.com/products/tasquinimod.html","C20H17F3N2O4","free base","ABR-215050","COC1=C2C(=C(C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C2=CC=C1)O",2.797,3,1,4]
["S7618","MI-2 (Menin-MLL Inhibitor)","h10","L6200-18","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.",375.55,"1271738-62-5",{"v":75,"d":"75.00"},199.71,"<1","N/A","http://selleckchem.com/products/mi-2-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.161,3,0,4]
["S7619","MI-3 (Menin-MLL Inhibitor)","a11","L6200-18","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.",375.55,"1271738-59-0",{"v":19,"d":"19.00"},50.59,"<1","N/A","http://selleckchem.com/products/mi-3-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CC(C)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.168,3,0,3]
["S7620","GSK1324726A (I-BET726)","b11","L6200-18","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK1324726A (I-BET726) is a highly selective inhibitor of BET family proteins with IC50 of 41 nM, 31 nM, and 22 nM for BRD2, BRD3, and BRD4, respectively.",434.91,"1300031-52-0",{"v":86,"d":"86.00"},197.74,"<1","N/A","http://selleckchem.com/products/gsk1324726a-i-bet726.html","C25H23ClN2O3","free base","N/A","CC1CC(NC2=CC=C(Cl)C=C2)C3=C(C=CC(=C3)C4=CC=C(C=C4)C(O)=O)N1C(C)=O",4.648,2,1,4]
["S7623","PI-3065","c11","L6200-18","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.",506.64,"955977-50-1",{"v":50,"d":"50.00"},98.69,"<1","N/A","http://selleckchem.com/products/pi-3065.html","C27H31FN6OS","free base","N/A","FC1=C(C2=NC3=C(SC(=C3)CN4CCN(CC4)CC5CC5)C(=N2)N6CCOCC6)C7=C([NH]C=C7)C=C1",4.778,3,1,6]
["S7624","SD-208","d11","L6200-18","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.",352.75,"627536-09-8",{"v":9,"d":"9.00"},25.51,"<1","N/A","http://selleckchem.com/products/sd-208.html","C17H10ClFN6","free base","N/A","FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4",3.139,5,1,3]
["S7625","Niraparib (MK-4827) tosylate","e11","L6200-18","in 10mM DMSO","Apoptosis related,PARP","DNA Damage/DNA Repair","Niraparib tosylate (MK-4827, ZEJULA) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. Niraparib increases formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death.",492.59,"1038915-73-9",{"v":98,"d":"98.00"},198.95,"<1","N/A","http://selleckchem.com/products/mk-4827-niraparib-tosylate.html","C19H20N4O.C7H8O3S","4-?methylbenzen","Niraparib tosylate, MK 4827 tosylate, ZEJULA","CC1=CC=C(C=C1)[S](O)(=O)=O.NC(=O)C2=CC=CC3=C[N](N=C23)C4=CC=C(C=C4)C5CCCNC5",4.267,2,2,4]
["S7627","LDN-214117","f11","L6200-18","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LDN-214117 is a potent and selective BMP type I receptor kinase ALK2 inhibitor with IC50 of 24 nM.",419.52,"1627503-67-6",{"v":83,"d":"83.00"},197.85,"<1","N/A","http://selleckchem.com/products/ldn-214117.html","C25H29N3O3","free base","N/A","COC1=CC(=CC(=C1OC)OC)C2=CC(=CN=C2C)C3=CC=C(C=C3)N4CCNCC4",3.533,4,1,6]
["S7631","TH287","g11","L6200-18","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.",269.13,"1609960-30-6",{"v":53,"d":"53.00"},196.93,"<1","N/A","http://selleckchem.com/products/th287.html","C11H10Cl2N4","free base","N/A","CNC1=CC(=NC(=N1)N)C2=C(Cl)C(=CC=C2)Cl",3.449,2,2,2]
["S7632","TH588","h11","L6200-18","in 10mM DMSO","MTH1,NUDIX","DNA Damage/DNA Repair","TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.",295.17,"1609960-31-7",{"v":20,"d":"20.00"},67.76,"<1","N/A","http://selleckchem.com/products/th588.html","C13H12Cl2N4","free base","N/A","NC1=NC(=CC(=N1)NC2CC2)C3=C(Cl)C(=CC=C3)Cl",3.938,2,2,3]
["S7634","Cerdulatinib (PRT062070) hydrochloride","a2","L6200-19","in 10mM DMSO","JAK,Syk","JAK/STAT","Cerdulatinib (PRT-062070, PRT2070) hydrochloride is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.",{"v":482,"d":"482.00"},"1369761-01-2",{"v":43,"d":"43.00"},89.21,"<1","N/A","http://selleckchem.com/products/cerdulatinib-prt062070-prt2070.html","C20H28ClN7O3S","hydrochloride","PRT2070 hydrochloride","Cl.CC[S](=O)(=O)N1CCN(CC1)C2=CC=C(NC3=NC(=C(C=N3)C(N)=O)NC4CC4)C=C2",1.862,5,3,8]
["S7636","SU9516","b2","L6200-19","in 10mM DMSO","CDK","Cell Cycle","SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.",241.25,"377090-84-1",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/su9516.html","C13H11N3O2","free base","N/A","COC1=CC=C2NC(=O)C(=C\\C3=CN=C[NH]3)/C2=C1",0.893,3,2,2]
["S7641","Remodelin hydrobromide","c2","L6200-19","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.",363.28,"1622921-15-6",{"v":72,"d":"72.00"},198.19,"<1","N/A","http://selleckchem.com/products/remodelin.html","C15H15BrN4S","hydrobromide","Remodelin HBr","Br.N#CC1=CC=C(C=C1)C2=CSC(=N2)NN=C3CCCC3",4.031,2,1,3]
["S7642","D 4476","d2","L6200-19","in 10mM DMSO","Casein Kinase","Metabolism","D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.",398.41,"301836-43-1",{"v":79,"d":"79.00"},198.29,"<1","N/A","http://selleckchem.com/products/d-4476.html","C23H18N4O3","free base","N/A","NC(=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=CC=N3)C4=CC5=C(OCCO5)C=C4",3.464,5,2,4]
["S7645","Pilaralisib (XL147)","e2","L6200-19","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2.",541.02,"934526-89-3",{"v":100,"d":"100.00"},184.84,"<1","N/A","http://selleckchem.com/products/pilaralisib-xl147.html","C25H25ClN6O4S","free base","N/A","COC1=CC(=C(Cl)C=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=CC(=C4)NC(=O)C(C)(C)N",4.012,6,4,8]
["S7646","Voxtalisib (XL765)","f2","L6200-19","in 10mM DMSO","mTOR,PI3K","Angiogenesis","Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",270.29,"934493-76-2",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/voxtalisib-xl765-sar245409.html","C13H14N6O","free base","SAR245409","CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C3=CC=N[NH]3",0.838,4,2,2]
["S7648","OTS964","g2","L6200-19","in 10mM DMSO","Apoptosis related,Autophagy,CDK,TOPK","MAPK","OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.",428.97,"1338545-07-5",{"v":85,"d":"85.00"},198.15,"<1","N/A","http://selleckchem.com/products/ots964.html","C23H24N2O2S.HCl","dihydrochloride","N/A","Cl.Cl.CC(CN(C)C)C1=CC=C(C=C1)C2=C3C(=C(C)C=C2O)NC(=O)C4=C3C=CS4",5.497,1,2,4]
["S7649","MI-773 (SAR405838)","h2","L6200-19","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7650","Peficitinib (ASP015K)","a3","L6200-19","in 10mM DMSO","JAK","JAK/STAT","Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.",326.39,"944118-01-8",{"v":65,"d":"65.00"},199.15,"<1","N/A","http://selleckchem.com/products/peficitinb-asp015k-jnj-54781532.html","C18H22N4O2","free base","JNJ-54781532","NC(=O)C1=C(N[CH]2C3C[CH]4CC2C[C](O)(C4)C3)C5=C([NH]C=C5)N=C1",1.023,2,3,3]
["S7655","Telaglenastat (CB-839)","b3","L6200-19","in 10mM DMSO","Autophagy,Glutaminase","Proteases","Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Phase 1.",571.57,"1439399-58-2",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/cb-839.html","C26H24F3N7O3S","free base","N/A","FC(F)(F)OC1=CC(=CC=C1)CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2",5.597,8,2,13]
["S7656","CPI-360","c3","L6200-19","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.",437.53,"1802175-06-9",{"v":20,"d":"20.00"},45.71,"<1","N/A","http://selleckchem.com/products/cpi-360.html","C25H31N3O4","free base","N/A","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCOCC3)C4=C2C=CC=C4)C(=O)NC(=C1)C",2.071,4,2,6]
["S7658","Kartogenin","d3","L6200-19","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.",317.34,"4727-31-5",{"v":63,"d":"63.00"},198.53,"<1","N/A","http://selleckchem.com/products/kartogenin.html","C20H15NO3","free base","KGN","OC(=O)C1=C(C=CC=C1)C(=O)NC2=CC=C(C=C2)C3=CC=CC=C3",3.762,2,1,4]
["S7660","Obeticholic Acid","e3","L6200-19","in 10mM DMSO","Autophagy,FXR","Metabolism","Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.",420.63,"459789-99-2",{"v":84,"d":"84.00"},{"v":199.7,"d":"199.70"},"<1","N/A","http://selleckchem.com/products/obeticholic-acid.html","C26H44O4","free base","INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid","CCC1C(O)C2C3CCC(C(C)CCC(O)=O)C3(C)CCC2C4(C)CCC(O)CC14",{"v":4.79,"d":"4.790"},1,2,5]
["S7663","Ruboxistaurin (LY333531) HCl","f3","L6200-19","in 10mM DMSO","PKC","TGF-beta/Smad","Ruboxistaurin (LY333531) HCl is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.",505.01,"169939-93-9",{"v":50,"d":"50.00"},99.01,"<1","N/A","http://selleckchem.com/products/ly333531.html","C28H28N4O3.HCl","hydrochloride","Ruboxistaurin hydrochloride,  LY333531 hydrochloride","Cl.CN(C)CC1CC[N]2C=C(C3=C2C=CC=C3)C4=C(C(=O)NC4=O)C5=C[N](CCO1)C6=C5C=CC=C6",3.861,3,1,2]
["S7664","GSK2578215A","g3","L6200-19","in 10mM DMSO","LRRK2","Autophagy","GSK2578215A is a potent and selective LRRK2 kinase inhibitor with IC50 of 8.9 nM and 10.9 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.",399.42,"1285515-21-0",{"v":79,"d":"79.00"},197.79,"<1","N/A","http://selleckchem.com/products/gsk2578215a.html","C24H18FN3O2","free base","N/A","FC1=NC=CC(=C1)C2=CC(=C(OCC3=CC=CC=C3)C=C2)C(=O)NC4=CC=CN=C4",3.985,4,1,6]
["S7668","Picropodophyllin (PPP)","h3","L6200-19","in 10mM DMSO","Apoptosis related,IGF-1R","Protein Tyrosine Kinase","Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.",414.41,"477-47-4",{"v":82,"d":"82.00"},197.87,"<1","N/A","http://selleckchem.com/products/picropodophyllin-ppp.html","C22H22O8","free base","AXL1717","COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24",2.111,7,1,4]
["S7672","Omaveloxolone (RTA-408)","a4","L6200-19","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.",554.71,"1474034-05-3",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/omaveloxolone-rta-408.html","C33H44F2N2O3","free base","N/A","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C3(C)CCC5C(C)(C)C(=O)C(=CC45C)C#N)NC(=O)C(C)(F)F",5.339,3,1,2]
["S7673","L-685,458","b4","L6200-19","in 10mM DMSO","Secretase","Proteases","L-685,458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.",672.85,"292632-98-5",{"v":100,"d":"100.00"},148.62,"<1","N/A","http://selleckchem.com/products/l-685-458.html","C39H52N4O6","free base","N/A","CC(C)CC(NC(=O)C(CC(O)C(CC1=CC=CC=C1)NC(=O)OC(C)(C)C)CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(N)=O",{"v":5.62,"d":"5.620"},5,5,19]
["S7675","PF-4989216","c4","L6200-19","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.",{"v":380.4,"d":"380.40"},"1276553-09-3",{"v":76,"d":"76.00"},199.79,"<1","N/A","http://selleckchem.com/products/pf-4989216.html","C18H13FN6OS","free base","N/A","FC1=C(C=CC(=C1)C#N)C2=C(SC(=C2C#N)N3CCOCC3)C4=NC=N[NH]4",2.924,3,1,3]
["S7678","Sacubitril/valsartan (LCZ696)","d4","L6200-19","in 10mM DMSO","Angiotensin Receptor,Apoptosis related,Neprilysin","Proteases","Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.",915.98,"936623-90-4",{"v":30,"d":"30.00"},32.75,{"v":100,"d":"100.00"},109.17,"http://selleckchem.com/products/lcz696.html","C24H29N5O3.C24H29NO5.5/2H2O.3Na","Sodium salt hydrate","Sacubitril, Valsartan","[Na+].[Na+].[Na+].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[NH]3)C(C(C)C)C(O)=O.CCOC(=O)C(C)CC(CC4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)CCC(O)=O",8.591,9,2,22]
["S7679","YK-4-279","e4","L6200-19","in 10mM DMSO","DNA/RNA Synthesis","Cell Cycle","YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).",{"v":366.2,"d":"366.20"},"1037184-44-3",{"v":73,"d":"73.00"},199.34,"<1","N/A","http://selleckchem.com/products/yk-4-279.html","C17H13Cl2NO4","free base","N/A","COC1=CC=C(C=C1)C(=O)CC2(O)C(=O)NC3=C(Cl)C=CC(=C23)Cl",2.946,3,1,4]
["S7680","SP2509","f4","L6200-19","in 10mM DMSO","Apoptosis related,Autophagy,Histone Demethylase,LSD1","Epigenetics","SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of  13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.",{"v":437.9,"d":"437.90"},"1423715-09-6",{"v":38,"d":"38.00"},86.78,"<1","N/A","http://selleckchem.com/products/sp2509.html","C19H20ClN3O5S","free base","HCI-2509","CC(=N\\NC(=O)C1=CC=CC(=C1)[S](=O)(=O)N2CCOCC2)/C3=CC(=CC=C3O)Cl",1.891,5,2,5]
["S7681","OF-1","g4","L6200-19","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.",440.31,"919973-83-4",{"v":76,"d":"76.00"},172.61,"<1","N/A","http://selleckchem.com/products/of-1.html","C17H18BrN3O4S","free base","N/A","COC1=CC2=C(C=C1N[S](=O)(=O)C3=C(C)C=C(Br)C=C3)N(C)C(=O)N2C",{"v":2.81,"d":"2.810"},4,1,4]
["S7683","PIK-III","h4","L6200-19","in 10mM DMSO","Autophagy,LC3,PI3K","Autophagy","PIK-III (VPS34-IN2), which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.",319.36,"1383716-40-2",{"v":63,"d":"63.00"},197.27,"<1","N/A","http://selleckchem.com/products/pik-iii.html","C17H17N7","free base","VPS34-IN2","NC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",{"v":2.2,"d":"2.200"},5,2,5]
["S7684","Salirasib","a5","L6200-19","in 10mM DMSO","Autophagy,PPMTase,Ras","Cell Cycle","Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.",358.54,"162520-00-5","The physical form of the compound is fat, and can be dissolved in any proportion in DMSO","N/A","N/A","N/A","http://selleckchem.com/products/salirasib.html","C22H30O2S","free base","Farnesylthiosalicylic acid, FTS","CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC1=CC=CC=C1C(O)=O",{"v":7.12,"d":"7.120"},1,0,10]
["S7686","ML141","b5","L6200-19","in 10mM DMSO","Apoptosis related,p38 MAPK,Rho","Cell Cycle","ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.",407.49,"71203-35-5",{"v":81,"d":"81.00"},198.78,"<1","N/A","http://selleckchem.com/products/ml141.html","C22H21N3O3S","free base","CID-2950007","COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)[S](N)(=O)=O)C4=CC=CC=C4",{"v":3.87,"d":"3.870"},4,1,5]
["S7687","GSK269962A HCl","c5","L6200-19","in 10mM DMSO","ROCK","Cell Cycle","GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.",607.06,"2095432-71-4",{"v":100,"d":"100.00"},164.73,"<1","N/A","http://selleckchem.com/products/gsk269962.html","C29H30N8O5.HCl","hydrochloride","GSK269962B, GSK269962, GSK 269962","Cl.CC[N]1C2=C(C=NC(=C2)OC3=CC(=CC=C3)NC(=O)C4=CC=C(OCCN5CCOCC5)C=C4)N=C1C6=NON=C6N",3.776,9,2,10]
["S7689","BG45","d5","L6200-19","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","BG45 is a class I HDAC inhibitor with IC50 of 289 nM, 2.0 µM, 2.2 µM and >20 µM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively.",214.22,"926259-99-6",{"v":42,"d":"42.00"},196.06,"<1","N/A","http://selleckchem.com/products/bg45.html","C11H10N4O","free base","N/A","NC1=CC=CC=C1NC(=O)C2=NC=CN=C2",-0.005,3,2,2]
["S7691","PS-1145","e5","L6200-19","in 10mM DMSO","IκB/IKK","NF-κB","PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.",322.75,"431898-65-6",{"v":64,"d":"64.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://selleckchem.com/products/ps-1145.html","C17H11ClN4O","free base","N/A","ClC1=CC(=C2[NH]C3=C(C=CN=C3)C2=C1)NC(=O)C4=CN=CC=C4",2.471,3,2,2]
["S7693","Ceralasertib (AZD6738)","f5","L6200-19","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2.",412.51,"1352226-88-0",{"v":82,"d":"82.00"},198.78,"<1","N/A","http://selleckchem.com/products/azd6738.html","C20H24N6O2S","free base","N/A","CC1COCCN1C2=NC(=NC(=C2)C3(CC3)[S](C)(=N)=O)C4=C5C=C[NH]C5=NC=C4",2.427,5,1,4]
["S7694","AZD8186","g5","L6200-19","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.",457.47,"1627494-13-6",{"v":91,"d":"91.00"},198.92,"<1","N/A","http://selleckchem.com/products/azd8186.html","C24H25F2N3O4","free base","N/A","CC(NC1=CC(=CC(=C1)F)F)C2=CC(=CC3=C2OC(=CC3=O)N4CCOCC4)C(=O)N(C)C",3.418,4,1,5]
["S7697","LY2409881","h5","L6200-19","in 10mM DMSO","IκB/IKK","NF-κB","LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.",594.43,"946518-60-1",{"v":20,"d":"20.00"},33.65,"<1","N/A","http://selleckchem.com/products/ly2409881.html","C24H32Cl4N6OS","trihydrochloride","N/A","Cl.Cl.Cl.CN1CCN(CCCNC2=NC=C(Cl)C(=N2)C3=CC4=C(S3)C=CC=C4C(=O)NC5CC5)CC1",5.147,3,2,8]
["S7704","LY2584702 Tosylate","a6","L6200-19","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.",617.62,"1082949-68-5",{"v":7,"d":"7.00"},11.33,"<1","N/A","http://selleckchem.com/products/ly2584702-tosylate.html","C28H27F4N7O3S","free base","N/A","C[N]1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=N[NH]4)C5=CC(=C(F)C=C5)C(F)(F)F.CC6=CC=C(C=C6)[S](O)(=O)=O",5.829,4,1,5]
["S7709","VX-11e","b6","L6200-19","in 10mM DMSO","ERK","MAPK","VX-11e (VTX-11e, Vertex-11e) is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.",500.35,"896720-20-0",{"v":100,"d":"100.00"},199.86,"<1","N/A","http://selleckchem.com/products/vx-11e.html","C24H20Cl2FN5O2","free base","VTX-11e, Vertex-11e","CC1=CN=C(NC2=C(Cl)C=C(F)C=C2)N=C1C3=C[NH]C(=C3)C(=O)NC(CO)C4=CC=CC(=C4)Cl",5.755,3,4,7]
["S7718","BMH-21","c6","L6200-19","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.",360.41,"896705-16-1",{"v":5,"d":"5.00"},13.87,"<1","N/A","http://selleckchem.com/products/bmh-21.html","C21H20N4O2","free base","N/A","CN(C)CCNC(=O)C1=CC=CN2C(=O)C3=C(C=C4C=CC=CC4=C3)N=C12",1.552,3,1,4]
["S7720","SBE 13 HCl","d6","L6200-19","in 10mM DMSO","PLK","Cell Cycle","SBE 13 HCl is a potent and selective PLK1 inhibitor with IC50 of 200 pM, >4000-fold selectivity over Aurora A kinase, Plk2 and Plk3.",{"v":479.4,"d":"479.40"},"1052532-15-6",{"v":95,"d":"95.00"},198.16,"<1","N/A","http://selleckchem.com/products/sbe-13-hcl.html","C24H28Cl2N2O4","hydrochloride","N/A","Cl.COC1=CC=C(CCNCC2=CC=C(OCC3=CN=C(Cl)C=C3)C(=C2)OC)C=C1OC",4.895,5,1,11]
["S7721","Monomethyl auristatin E (MMAE)","e6","L6200-19","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .",717.98,"474645-27-7",{"v":100,"d":"100.00"},139.28,"<1","N/A","http://selleckchem.com/products/monomethyl-auristatin-e-mmae.html","C39H67N5O7","free base","SGD-1010","CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C)C(O)C2=CC=CC=C2)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C",{"v":3.46,"d":"3.460"},6,4,20]
["S7722","Bikinin","f6","L6200-19","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.",273.08,"188011-69-0",{"v":54,"d":"54.00"},197.74,"<1","N/A","http://selleckchem.com/products/bikinin.html","C9H9BrN2O3","free base","N/A","OC(=O)CCC(=O)NC1=NC=C(Br)C=C1",0.932,3,1,4]
["S7723","PRIMA-1","g6","L6200-19","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7724","Eprenetapopt (APR-246)","h6","L6200-19","in 10mM DMSO","Apoptosis related,Autophagy,p53","Apoptosis","Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.",199.25,"5291-32-7",{"v":40,"d":"40.00"},200.75,"N/A","N/A","http://selleckchem.com/products/apr-246-prima-1met.html","C10H17NO3","free base","PRIMA-1MET","COCC1(CO)N2CCC(CC2)C1=O",-0.364,2,1,3]
["S7726","BRD73954","a7","L6200-19","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","BRD73954 is a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.",284.31,"1440209-96-0",{"v":56,"d":"56.00"},196.97,"<1","N/A","http://selleckchem.com/products/brd73954.html","C16H16N2O3","free base","N/A","ONC(=O)C1=CC=CC(=C1)C(=O)NCCC2=CC=CC=C2",1.957,2,2,5]
["S7730","NU1025","b7","L6200-19","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NU1025 (NSC 696807) is a potent PARP inhibitor with IC50 of 400 nM.",176.17,"90417-38-2",{"v":35,"d":"35.00"},198.67,"<1","N/A","http://selleckchem.com/products/nu1025.html","C9H8N2O2","free base","NSC 696807","CC1=NC2=C(C=CC=C2O)C(=O)N1",0.587,2,2,0]
["S7731","AZD3839","c7","L6200-19","in 10mM DMSO","BACE","Neuronal Signaling","AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.",431.41,"1227163-84-9",{"v":86,"d":"86.00"},199.35,"<1","N/A","http://selleckchem.com/products/azd3839.html","C24H16F3N5","free base","N/A","NC1=NC(C2=CC=CC(=C2)C3=CN=CN=C3)(C4=CC(=NC=C4)C(F)F)C5=CC=CC(=C15)F",3.574,4,1,4]
["S7734","LFM-A13","d7","L6200-19","in 10mM DMSO","BTK","Angiogenesis","LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with IC50 of 2.5 μM, >100-fold selectivity over other protein kinases including JAK1, JAK2, HCK, EGFR,and IRK.",{"v":360,"d":"360.00"},"244240-24-2",{"v":72,"d":"72.00"},{"v":200,"d":"200.00"},"<1","N/A","http://selleckchem.com/products/lfm-a13.html","C11H8Br2N2O2","free base","N/A","C/C(O)=C(C#N)/C(=O)NC1=C(Br)C=CC(=C1)Br",2.645,1,2,2]
["S7741","SB239063","e7","L6200-19","in 10mM DMSO","p38 MAPK","MAPK","SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.",{"v":368.4,"d":"368.40"},"193551-21-2",{"v":60,"d":"60.00"},162.87,"<1","N/A","http://selleckchem.com/products/sb239063.html","C20H21FN4O2","free base","N/A","COC1=NC=CC(=N1)C2=C(N=C[N]2C3CCC(O)CC3)C4=CC=C(F)C=C4",3.661,4,1,4]
["S7742","SCR7","f7","L6200-19","in 10mM DMSO","CRISPR/Cas9,DNA/RNA Synthesis","DNA Damage/DNA Repair","SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).  It increases the efficiency of HDR-mediated genome editing up to 19-fold using CRISPR/Cas9 in mammalian cells and mouse embryos.",332.38,"14892-97-8",{"v":66,"d":"66.00"},198.57,"<1","N/A","http://selleckchem.com/products/scr7.html","C18H12N4OS","free base","N/A","O=C1NC(=S)NC2=C1N=C(C3=CC=CC=C3)C(=N2)C4=CC=CC=C4",4.496,3,2,2]
["S7747","Ro-3306","g7","L6200-19","in 10mM DMSO","Apoptosis related,Bcl-2,CDK","Cell Cycle","RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with Ki of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis.",351.45,"872573-93-8",{"v":13,"d":"13.00"},36.99,"<1","N/A","http://selleckchem.com/products/ro-3306.html","C18H13N3OS2","free base","N/A","O=C1N=C(NCC2=CC=CS2)S\\C1=C/C3=CC=C4N=CC=CC4=C3",3.712,3,1,4]
["S7748","EPZ015666 (GSK3235025)","h7","L6200-19","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.",383.44,"1616391-65-1",{"v":60,"d":"60.00"},156.48,"<1","N/A","http://selleckchem.com/products/epz015666.html","C20H25N5O3","free base","GSK3235025","OC(CNC(=O)C1=CC(=NC=N1)NC2COC2)CN3CCC4=C(C3)C=CC=C4",1.038,4,3,7]
["S7750","KNK437","a8","L6200-19","in 10mM DMSO","HSP (HSP90)","Cell Cycle","KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.",245.23,"218924-25-5",{"v":15,"d":"15.00"},61.17,"<1","N/A","http://selleckchem.com/products/knk437.html","C13H11NO4","free base","N/A","O=CN1CCC(=C/C2=CC3=C(OCO3)C=C2)/C1=O",{"v":1.22,"d":"1.220"},4,0,1]
["S7751","VER155008","b8","L6200-19","in 10mM DMSO","Autophagy,HSP (HSP90)","Cytoskeletal Signaling","VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.",{"v":556.4,"d":"556.40"},"1134156-31-2",{"v":100,"d":"100.00"},179.73,"<1","N/A","http://selleckchem.com/products/ver155008.html","C25H23Cl2N7O4","free base","C07","NC1=C2N=C(NCC3=CC=C(Cl)C(=C3)Cl)[N](C4OC(COCC5=CC=C(C=C5)C#N)C(O)C4O)C2=NC=N1",3.253,5,4,8]
["S7752","Pluripotin (SC1)","c8","L6200-19","in 10mM DMSO","ERK,S6 Kinase","MAPK","Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Pluripotin also inhibits RSK1, RSK2, RSK3 and RSK4 with IC50 of 0.5 µM, 2.5 µM, 3.3 µM and 10.0 µM, respectively.",550.53,"839707-37-8",{"v":100,"d":"100.00"},181.64,"<1","N/A","http://selleckchem.com/products/pluripotin-sc1.html","C27H25F3N8O2","free base","N/A","C[N]1N=C(C)C=C1NC2=NC=C3CN(C(=O)N(C)C3=N2)C4=CC(=CC=C4C)NC(=O)C5=CC=CC(=C5)C(F)(F)F",4.789,5,2,6]
["S7753","BPTES","d8","L6200-19","in 10mM DMSO","Glutaminase","Proteases","BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.",524.68,"314045-39-1",{"v":100,"d":"100.00"},190.59,"<1","N/A","http://selleckchem.com/products/bptes.html","C24H24N6O2S3","free base","N/A","O=C(CC1=CC=CC=C1)NC2=NN=C(CCSCCC3=NN=C(NC(=O)CC4=CC=CC=C4)S3)S2",3.432,6,2,12]
["S7757","6-Thio-dG","e8","L6200-19","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.",283.31,"789-61-7",{"v":56,"d":"56.00"},197.66,"<1","N/A","http://selleckchem.com/products/6-thio-dg.html","C10H13N5O3S","free base","β-TGdR","NC1=NC(=S)C2=C(N1)[N](C=N2)C3CC(O)C(CO)O3",-0.714,3,4,2]
["S7767","AZ6102","f8","L6200-19","in 10mM DMSO","PPAR","DNA Damage/DNA Repair","AZ6102 is a potent TNKS1/2  inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.",428.53,"1645286-75-4",{"v":85,"d":"85.00"},198.35,"<1","N/A","http://selleckchem.com/products/az6102.html","C25H28N6O","free base","AZ-6102","CC1CN(CC(C)N1)C2=NC=C(C(=C2)C)C3=CC=C(C=C3)C4=NC5=C(C=C[N]5C)C(=O)N4",3.649,3,2,3]
["S7769","BP-1-102","g8","L6200-19","in 10mM DMSO","STAT","JAK/STAT","BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM.",626.59,"1334493-07-0",{"v":100,"d":"100.00"},159.59,"<1","N/A","http://selleckchem.com/products/bp-1-102.html","C29H27F5N2O6S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC(=C(C=C3)C(O)=O)O)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",5.979,4,1,9]
["S7771","STF-083010","h8","L6200-19","in 10mM DMSO","IRE1","ER stress & UPR","STF-083010 is a specific IRE1α endonuclease inhibitor without affecting its kinase activity.",317.38,"307543-71-1",{"v":63,"d":"63.00"},{"v":198.5,"d":"198.50"},"<1","N/A","http://selleckchem.com/products/stf-083010.html","C15H11NO3S2","free base","N/A","OC1=CC=C2C=CC=CC2=C1C=N[S](=O)(=O)C3=CC=CS3",3.454,3,1,3]
["S7774","SU6656","a9","L6200-19","in 10mM DMSO","Src","Angiogenesis","SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.",371.45,"330161-87-0",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://selleckchem.com/products/su6656.html","C19H21N3O3S","free base","N/A","CN(C)[S](=O)(=O)C1=CC=C2NC(=O)C(=C\\C3=CC4=C(CCCC4)[NH]3)/C2=C1",2.616,3,2,3]
["S7775","Emricasan (IDN-6556)","b9","L6200-19","in 10mM DMSO","Antiviral,Caspase","Apoptosis","Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.",{"v":569.5,"d":"569.50"},"254750-02-2",{"v":100,"d":"100.00"},175.59,"<1","N/A","http://selleckchem.com/products/emricasan-idn-6556-pf-03491390.html","C26H27F4N3O7","free base","PF 03491390, PF-03491390","CC(NC(=O)C(=O)NC1=C(C=CC=C1)C(C)(C)C)C(=O)NC(CC(O)=O)C(=O)COC2=C(F)C(=CC(=C2F)F)F",3.017,6,3,12]
["S7776","Akti-1/2","c9","L6200-19","in 10mM DMSO","Akt,Apoptosis related","PI3K/Akt/mTOR","Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.",551.64,"612847-09-3",{"v":22,"d":"22.00"},39.88,"<1","N/A","http://selleckchem.com/products/akti-1-2.html","C34H29N7O","free base","Akt Inhibitor VIII","O=C1NC2=C(C=CC=C2)N1C3CCN(CC3)CC4=CC=C(C=C4)C5=C(N=C6C=C7[NH]C=NC7=CC6=N5)C8=CC=CC=C8",5.466,4,2,5]
["S7779","Smoothened Agonist (SAG) HCl","d9","L6200-19","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.",526.52,"2095432-58-7",{"v":71,"d":"71.00"},134.85,{"v":100,"d":"100.00"},189.93,"http://selleckchem.com/products/smoothened-agonist-sag-hcl.html","C28H29Cl2N3OS","Hydrochloride","N/A","Cl.CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(Cl)C5=C(S4)C=CC=C5",6.158,2,1,6]
["S7781","Sunitinib (SU11248)","e9","L6200-19","in 10mM DMSO","Apoptosis related,Autophagy,c-Kit,IRE1,PDGFR,VEGFR","Protein Tyrosine Kinase","Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.",398.47,"557795-19-4",{"v":25,"d":"25.00"},62.74,"<1","N/A","http://selleckchem.com/products/sunitinib.html","C22H27FN4O2","free base","SU11248","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)/C=C/2C(=O)NC3=C2C=C(F)C=C3",2.997,2,3,7]
["S7783","Combretastatin A4","f9","L6200-19","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.Phase 3.",316.35,"117048-59-6",{"v":63,"d":"63.00"},199.15,"<1","N/A","http://selleckchem.com/products/combretastatin-a4.html","C18H20O5","free base","N/A","COC1=C(O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",3.508,4,1,6]
["S7786","Erlotinib (OSI-774)","g9","L6200-19","in 10mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.",393.44,"183321-74-6",{"v":78,"d":"78.00"},198.25,"<1","N/A","http://selleckchem.com/products/erlotinib.html","C22H23N3O4","free base","CP358774, NSC 718781, Tarceva","COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.309,6,1,10]
["S7787","Docetaxel Trihydrate","h9","L6200-19","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Docetaxel (RP56976, NSC 628503), an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.",861.93,"148408-66-6",{"v":100,"d":"100.00"},116.02,"<1","N/A","http://selleckchem.com/products/docetaxel-trihydrate.html","C43H53NO14.3H2O","Trihydrate","RP56976 (NSC 628503) Trihydrate","O.O.O.CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)C6=CC=CC=C6)C(=C(C(O)C3=O)C5(C)C)C",1.964,10,4,13]
["S7792","SRT2104 (GSK2245840)","a10","L6200-19","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.",516.64,"1093403-33-8",{"v":16,"d":"16.00"},30.97,"<1","N/A","http://selleckchem.com/products/srt2104-gsk2245840.html","C26H24N6O2S2","free base","N/A","CC1=C(SC(=N1)C2=CC=CN=C2)C(=O)NC3=C(C=CC=C3)C4=C[N]5C(=CSC5=N4)CN6CCOCC6",2.813,5,1,6]
["S7793","Purvalanol A","b10","L6200-19","in 10mM DMSO","Apoptosis related,Autophagy,CDK","Cell Cycle","Purvalanol A is a potent, and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated apoptosis and autophagy.",388.89,"212844-53-6",{"v":60,"d":"60.00"},154.29,"<1","N/A","http://selleckchem.com/products/purvalanol-a.html","C19H25ClN6O","free base","N/A","CC(C)C(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NC3=CC=CC(=C3)Cl",4.462,3,3,7]
["S7795","Iadademstat (ORY-1001) 2HCl","c10","L6200-19","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.",303.27,"1431326-61-2",{"v":5,"d":"5.00"},16.49,{"v":61,"d":"61.00"},201.14,"http://selleckchem.com/products/ory-1001-rg-6016.html","C15H22N2.2HCl","dihydrochloride","RG-6016","Cl.Cl.NC1CCC(CC1)NC2CC2C3=CC=CC=C3",2.721,0,2,3]
["S7796","GSK2879552 2HCl","d10","L6200-19","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.",{"v":437.4,"d":"437.40"},"1902123-72-1",{"v":29,"d":"29.00"},{"v":66.3,"d":"66.30"},{"v":44,"d":"44.00"},100.59,"http://selleckchem.com/products/gsk2879552-2hcl.html","C23H28N2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OC(=O)C1=CC=C(CN2CCC(CC2)CNC3CC3C4=CC=CC=C4)C=C1",1.586,1,1,7]
["S7798","GNE-317","e10","L6200-19","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GNE-317 is a potent, brain-penetrant PI3K inhibitor.",414.48,"1394076-92-6",{"v":47,"d":"47.00"},{"v":113.4,"d":"113.40"},"<1","N/A","http://selleckchem.com/products/gne-317.html","C19H22N6O3S","free base","N/A","COC1(COC1)C2=C(C)C3=C(S2)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",{"v":1.5,"d":"1.500"},7,1,4]
["S7799","Pexmetinib (ARRY-614)","f10","L6200-19","in 10mM DMSO","p38 MAPK,Tie-2","MAPK","Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor  with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.",556.63,"945614-12-0",{"v":100,"d":"100.00"},179.65,"<1","N/A","http://selleckchem.com/products/pexmetinib-arry-614.html","C31H33FN6O3","free base","N/A","CC1=CC=C(C=C1)[N]2N=C(C=C2NC(=O)NCC3=C(OC4=CC5=C(C=C4)[N](CCO)N=C5)C=CC(=C3)F)C(C)(C)C",6.271,4,3,9]
["S7804","GSK503","g10","L6200-19","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK503 is a potent and specific EZH2 methyltransferase inhibitor.",526.67,"1346572-63-1",{"v":100,"d":"100.00"},189.87,"<1","N/A","http://selleckchem.com/products/gsk503.html","C31H38N6O2","free base","N/A","CC(C)[N]1C=C(C)C2=C1C=C(C=C2C(=O)NCC3=C(C)C=C(C)NC3=O)C4=CC=C(N=C4)N5CCN(C)CC5",4.126,3,2,6]
["S7807","FRAX486","h10","L6200-19","in 10mM DMSO","PAK","Cytoskeletal Signaling","FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of  14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.",513.39,"1232030-35-1",{"v":22,"d":"22.00"},42.85,"<1","N/A","http://selleckchem.com/products/frax486.html","C25H23Cl2FN6O","free base","N/A","CCN1C(=O)C(=CC2=CN=C(NC3=CC(=C(C=C3)N4CCNCC4)F)N=C12)C5=C(Cl)C=C(Cl)C=C5",5.235,3,2,5]
["S7808","AT7519 HCl","a11","L6200-19","in 10mM DMSO","CDK","Cell Cycle","AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.",418.71,"902135-91-5",{"v":52,"d":"52.00"},124.19,{"v":43,"d":"43.00"},{"v":102.7,"d":"102.70"},"http://selleckchem.com/products/at7519-hcl.html","C16H18Cl3N5O2","Hydrochloride","N/A","Cl.ClC1=CC=CC(=C1C(=O)NC2=C[NH]N=C2C(=O)NC3CCNCC3)Cl",{"v":1.98,"d":"1.980"},3,4,4]
["S7810","Afatinib (BIBW2992) Dimaleate","b11","L6200-19","in 10mM DMSO","Autophagy,EGFR,HER2","Protein Tyrosine Kinase","Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.",717.18,"850140-73-7",{"v":100,"d":"100.00"},139.44,"<1","N/A","http://selleckchem.com/products/afatinib-bibw2992-dimaleate.html","C24H25ClFN5O3.2C4H4O4","Dimaleate","N/A","CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",{"v":0.96,"d":"0.960"},9,2,12]
["S7811","MHY1485","c11","L6200-19","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.",387.39,"326914-06-1",{"v":4,"d":"4.00"},10.33,"<1","N/A","http://selleckchem.com/products/mhy1485.html","C17H21N7O4","free base","N/A","[O-][N+](=O)C1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C=C1",2.653,5,1,5]
["S7812","Itacitinib (INCB39110)","d11","L6200-19","in 10mM DMSO","JAK","JAK/STAT","Itacitinib(INCB39110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.",553.51,"1334298-90-6",{"v":100,"d":"100.00"},180.67,"<1","N/A","http://selleckchem.com/products/itacitinib-incb39110.html","C26H23F4N9O","free base","N/A","FC1=C(C=CN=C1C(F)(F)F)C(=O)N2CCC(CC2)N3CC(CC#N)(C3)[N]4C=C(C=N4)C5=C6C=C[NH]C6=NC=N5",2.422,5,1,6]
["S7813","AMG319","e11","L6200-19","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.",{"v":385.4,"d":"385.40"},"1608125-21-8",{"v":77,"d":"77.00"},199.79,"<1","N/A","http://selleckchem.com/products/amg319.html","C21H16FN7","free base","N/A","CC(NC1=C2N=C[NH]C2=NC=N1)C3=C(N=C4C=C(F)C=CC4=C3)C5=CC=CC=N5",3.691,5,2,4]
["S7815","MI-136","f11","L6200-19","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-136  can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.",470.51,"1628316-74-4",{"v":94,"d":"94.00"},199.78,"<1","N/A","http://selleckchem.com/products/mi-136.html","C23H21F3N6S","free base","N/A","FC(F)(F)CC1=CC2=C(NC3CCN(CC3)CC4=CC=C5[NH]C(=CC5=C4)C#N)N=CN=C2S1",4.886,2,2,6]
["S7816","MI-463","g11","L6200-19","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.",484.54,"1628317-18-9",{"v":96,"d":"96.00"},198.13,"<1","N/A","http://selleckchem.com/products/mi-463.html","C24H23F3N6S","free base","N/A","CC1=C2C=C([NH]C2=CC=C1CN3CCC(CC3)NC4=C5C=C(CC(F)(F)F)SC5=NC=N4)C#N",5.372,2,2,6]
["S7820","EPZ020411 2HCl","h11","L6200-19","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM.",515.52,"2070015-25-5",{"v":100,"d":"100.00"},193.98,{"v":81,"d":"81.00"},157.12,"http://selleckchem.com/products/epz020411.html","C25H40Cl2N4O3","dihydrochloride","N/A","Cl.Cl.CNCCN(C)CC1=C[NH]N=C1C2=CC=C(OC3CC(C3)OCCC4CCOCC4)C=C2",3.322,4,2,12]
["S7828","Licochalcone A","a2","L6200-20","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Licochalcone A is an estrogenic flavanoid extracted from licorice root, showing antimalarial, anticancer, antibacterial and antiviral activities. Phase 3.",{"v":338.4,"d":"338.40"},"58749-22-7",{"v":67,"d":"67.00"},197.99,"<1","N/A","http://selleckchem.com/products/licochalcone-a.html","C21H22O4","free base","N/A","COC1=C(/C=C/C(=O)C2=CC=C(O)C=C2)C=C(C(=C1)O)C(C)(C)C=C",4.667,2,2,6]
["S7829","CB1954","b2","L6200-20","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.",252.18,"21919-05-1",{"v":50,"d":"50.00"},198.27,"<1","N/A","http://selleckchem.com/products/cb1954.html","C9H8N4O5","free base","Tretazicar, NSC 115829","NC(=O)C1=C(C=C(C(=C1)N2CC2)[N+]([O-])=O)[N+]([O-])=O",0.601,1,1,4]
["S7832","SGC707","c2","L6200-20","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.",298.34,"1687736-54-4",{"v":59,"d":"59.00"},197.76,"<1","N/A","http://selleckchem.com/products/sgc707.html","C16H18N4O2","free base","N/A","O=C(NCC(=O)N1CCCC1)NC2=CC3=CC=NC=C3C=C2",{"v":0.43,"d":"0.430"},3,2,3]
["S7833","OICR-9429","d2","L6200-20","in 10mM DMSO","Histone Methyltransferase,WDR5","Epigenetics","OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.",555.59,"1801787-56-3",{"v":38,"d":"38.00"},{"v":68.4,"d":"68.40"},"<1","N/A","http://selleckchem.com/products/oicr-9429.html","C29H32F3N5O3","free base","N/A","CN1CCN(CC1)C2=CC=C(C=C2NC(=O)C3=CNC(=O)C=C3C(F)(F)F)C4=CC(=CC=C4)CN5CCOCC5",2.722,3,2,7]
["S7835","I-BRD9","e2","L6200-20","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","I-BRD9 (GSK602) is a potent and selective BRD9 inhibitor with pIC50 of 7.3, while it displayed a pIC50 of 5.3 against BRD4.",497.55,"1714146-59-4",{"v":99,"d":"99.00"},198.97,"<1","N/A","http://selleckchem.com/products/i-brd9-gsk602.html","C22H22F3N3O3S2","free base","GSK602","CCN1C=C(C2=CC(=CC=C2)C(F)(F)F)C3=C(C=C(S3)C(=N)NC4CC[S](=O)(=O)CC4)C1=O",2.779,3,1,6]
["S7843","BI-847325","f2","L6200-20","in 10mM DMSO","Aurora Kinase,MEK","MAPK","BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.",464.56,"1207293-36-4",{"v":19,"d":"19.00"},{"v":40.9,"d":"40.90"},"<1","N/A","http://selleckchem.com/products/bi-847325.html","C29H28N4O2","free base","N/A","CCNC(=O)C#CC1=CC=C\\2C(=C1)NC(=O)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4",4.041,2,3,8]
["S7845","SirReal2","g2","L6200-20","in 10mM DMSO","Sirtuin","Epigenetics","SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.",420.55,"709002-46-0",{"v":84,"d":"84.00"},199.74,"<1","N/A","http://selleckchem.com/products/sirreal2.html","C22H20N4OS2","free base","N/A","CC1=NC(=NC(=C1)C)SCC(=O)NC2=NC=C(CC3=CC=CC4=CC=CC=C34)S2",4.065,4,1,6]
["S7851","AZD3264","h2","L6200-20","in 10mM DMSO","IκB/IKK","NF-κB","AZD3264 is a novel IKK2 inhibitor.",{"v":441.5,"d":"441.50"},"1609281-86-8",{"v":88,"d":"88.00"},199.32,"<1","N/A","http://selleckchem.com/products/azd3264.html","C21H23N5O4S","free base","N/A","CC1=C(C(=NO1)C)C2=CC(=C(C=C2)C3=CC(=C(NC(N)=O)S3)C(N)=O)OC4CCNC4",1.235,5,4,6]
["S7854","Ulixertinib (BVD-523)","a3","L6200-20","in 10mM DMSO","ERK","MAPK","Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.",433.33,"869886-67-9",{"v":86,"d":"86.00"},198.46,"<1","N/A","http://selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html","C21H22Cl2N4O2","free base","VRT752271","CC(C)NC1=NC=C(Cl)C(=C1)C2=C[NH]C(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl",4.266,2,4,7]
["S7857","8-Bromo-cAMP","b3","L6200-20","in 10mM DMSO","PKA","GPCR & G Protein","8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.",430.08,"76939-46-3",{"v":5,"d":"5.00"},11.63,{"v":80,"d":"80.00"},186.01,"http://selleckchem.com/products/8-bromo-camp.html","C10H10BrN5NaO6P","sodium salt","8-Br-Camp,8-Bromo-cAMP Sodium","NC1=NC=NC2=C1N=C(Br)[N]2C3OC4CO[P](=O)(O[Na])OC4C3O",-0.479,7,2,2]
["S7858","Dibutyryl-cAMP (Bucladesine)","c3","L6200-20","in 10mM DMSO","PDE,PKA","GPCR & G Protein","Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.",491.37,"16980-89-5",{"v":98,"d":"98.00"},199.44,{"v":98,"d":"98.00"},199.44,"http://selleckchem.com/products/dibutyryl-camp-bucladesine.html","C18H23N5NaO8P","sodium salt","dbcAMP","CCCC(=O)NC1=NC=NC2=C1N=C[N]2C3OC4CO[P](=O)(O[Na])OC4C3OC(=O)CCC",1.028,10,1,9]
["S7863","SC79","d3","L6200-20","in 10mM DMSO","Akt","PI3K/Akt/mTOR","SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.",364.78,"305834-79-1",{"v":72,"d":"72.00"},197.38,"<1","N/A","http://selleckchem.com/products/sc79.html","C17H17ClN2O5","free base","N/A","CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Cl",2.427,5,1,7]
["S7864","Oltipraz","e3","L6200-20","in 10mM DMSO","Nrf2","Immunology & Inflammation","Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.",226.34,"64224-21-1",{"v":39,"d":"39.00"},172.31,"<1","N/A","http://selleckchem.com/products/oltipraz.html","C8H6N2S3","free base","N/A","CC1=C(SSC1=S)C2=NC=CN=C2",2.225,2,0,1]
["S7867","Oleuropein","f3","L6200-20","in 10mM DMSO","Anti-infection,Apoptosis related,Aromatase,PPAR","Immunology & Inflammation","Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.",540.51,"32619-42-4",{"v":100,"d":"100.00"},185.01,{"v":100,"d":"100.00"},185.01,"http://selleckchem.com/products/oleuropein.html","C25H32O13","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C\\C)C1CC(=O)OCCC3=CC(=C(O)C=C3)O",0.166,7,6,11]
["S7870","LJH685","g3","L6200-20","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.",381.42,"1627710-50-2",{"v":76,"d":"76.00"},199.26,"<1","N/A","http://selleckchem.com/products/ljh685.html","C22H21F2N3O","free base","N/A","CN1CCN(CC1)C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(O)C(=C4)F)F",4.004,1,1,3]
["S7871","LJI308","h3","L6200-20","in 10mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.",368.38,"1627709-94-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/lji308.html","C21H18F2N2O2","free base","N/A","OC1=C(F)C=C(C=C1F)C2=C(C=CN=C2)C3=CC=C(C=C3)N4CCOCC4",3.735,2,1,3]
["S7875","NVP-CGM097","a4","L6200-20","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7884","AMI-1","b4","L6200-20","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.",548.45,"20324-87-2",{"v":100,"d":"100.00"},182.33,{"v":10,"d":"10.00"},18.23,"http://selleckchem.com/products/ami-1.html","C21H14N2Na2O9S2","disodium salt","N/A","OC1=C2C=CC(=CC2=CC(=C1)[S](=O)(=O)O[Na])NC(=O)NC3=CC=C4C(=CC(=CC4=C3)[S](=O)(=O)O[Na])O",2.703,3,4,6]
["S7885","SBI-0206965","c4","L6200-20","in 10mM DMSO","Apoptosis related,Autophagy,ULK","Autophagy","SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells.",489.32,"1884220-36-3",{"v":97,"d":"97.00"},198.23,"<1","N/A","http://selleckchem.com/products/sbi-0206965.html","C21H21BrN4O5","free base","N/A","CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(OC)C(=C3)OC)OC",4.128,7,2,8]
["S7886","Onatasertib (CC 223)","d4","L6200-20","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.",397.47,"1228013-30-6",{"v":79,"d":"79.00"},198.76,"<1","N/A","http://selleckchem.com/products/cc-223.html","C21H27N5O3","free base","ATG-008","COC1CCC(CC1)N2C(=O)CNC3=NC=C(N=C23)C4=CN=C(C=C4)C(C)(C)O",{"v":1.66,"d":"1.660"},5,1,4]
["S7888","Spautin-1","e4","L6200-20","in 10mM DMSO","Apoptosis related,Autophagy,DUB","Autophagy","Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.",271.26,"1262888-28-7",{"v":54,"d":"54.00"},199.07,"<1","N/A","http://selleckchem.com/products/spautin-1.html","C15H11F2N3","free base","N/A","FC1=CC=C(CNC2=NC=NC3=CC=C(F)C=C23)C=C1",{"v":3.73,"d":"3.730"},2,1,3]
["S7889","Xanthohumol","f4","L6200-20","in 10mM DMSO","Acyltransferase,Apoptosis related,CMV,COX","Metabolism","Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.",{"v":354.4,"d":"354.40"},"6754-58-1",{"v":70,"d":"70.00"},197.52,"<1","N/A","http://selleckchem.com/products/xanthohumol.html","C21H22O5","free base","N/A","COC1=C(C(=C(CC=C(C)C)C(=C1)O)O)C(=O)\\C=C\\C2=CC=C(O)C=C2",4.816,2,3,6]
["S7891","CC-115","g4","L6200-20","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.",336.35,"1228013-15-7",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cc-115.html","C16H16N8O","free base","N/A","CCN1C(=O)CNC2=NC=C(N=C12)C3=C(C)N=C(C=C3)C4=N[NH]C=N4",0.664,6,2,3]
["S7892","Avadomide (CC-122)","h4","L6200-20","in 10mM DMSO","E3 Ligase ,Immunology & Inflammation related","Ubiquitin","Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.",286.29,"1015474-32-4",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/cc-122.html","C14H14N4O3","Free Base","N/A","CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N",-0.477,4,2,1]
["S7896","Sodium Tauroursodeoxycholate (TUDC)","a5","L6200-20","in 10mM DMSO","Anti-infection","Microbiology","Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.",521.69,"35807-85-3",{"v":100,"d":"100.00"},191.68,{"v":100,"d":"100.00"},191.68,"http://selleckchem.com/products/sodium-tauroursodeoxycholate-tudc.html","C26H44NNaO6S","sodium salt","N/A","CC(CCC(=O)NCC[S](=O)(=O)O[Na])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C",3.088,2,3,8]
["S7898","GSK621","b5","L6200-20","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","GSK621 is a specific and potent AMPK activator.",489.91,"1346607-05-3",{"v":97,"d":"97.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/gsk621.html","C26H20ClN3O5","free base","N/A","COC1=CC(=CC=C1)N2C(=O)NC3=C([N](C(=C3)Cl)C4=CC=C(C=C4)C5=C(O)C(=CC=C5)OC)C2=O",5.217,4,2,5]
["S7906","PFI-4","c5","L6200-20","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.",380.44,"900305-37-5",{"v":17,"d":"17.00"},44.69,"<1","N/A","http://selleckchem.com/products/pfi-4.html","C21H24N4O3","free base","N/A","COC1=C(C=CC=C1)C(=O)NC2=C(C=C3N(C)C(=O)N(C)C3=C2)N4CCCC4",2.496,3,1,4]
["S7914","Isoxazole 9 (ISX-9)","d5","L6200-20","in 10mM DMSO","TGF-beta/Smad,Wnt/beta-catenin","Stem Cells & Wnt","Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.",234.27,"832115-62-5",{"v":46,"d":"46.00"},196.35,"<1","N/A","http://selleckchem.com/products/isoxazole-9-isx-9.html","C11H10N2O2S","free base","N/A","O=C(NC1CC1)C2=NOC(=C2)C3=CC=CS3",2.173,3,1,3]
["S7915","BIO-acetoxime","e5","L6200-20","in 10mM DMSO","GSK-3","PI3K/Akt/mTOR","BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.",398.21,"667463-85-6",{"v":19,"d":"19.00"},47.71,"<1","N/A","http://selleckchem.com/products/bio-acetoxime.html","C18H12BrN3O3","free base","GSK-3 Inhibitor X","CC(=O)O\\N=C/1\\C(NC2=CC=CC=C12)=C3\\C(=O)NC4=C3C=CC(=C4)Br",2.515,4,2,2]
["S7917","Kenpaullone","f5","L6200-20","in 10mM DMSO","CDK","Cell Cycle","Kenpaullone (9-Bromopaullone, NSC-664704) is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.",327.18,"142273-20-9",{"v":65,"d":"65.00"},198.67,"<1","N/A","http://selleckchem.com/products/kenpaullone.html","C16H11BrN2O","free base","9-Bromopaullone, NSC-664704","BrC1=CC2=C([NH]C3=C2CC(=O)NC4=C3C=CC=C4)C=C1",3.671,1,2,0]
["S7918","Bromodeoxyuridine (BrdU)","g5","L6200-20","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Bromodeoxyuridine (BrdU, 5-Bromo-2'-deoxyuridine, BUdR) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells.",{"v":307.1,"d":"307.10"},"59-14-3",{"v":61,"d":"61.00"},198.63,"<1","N/A","http://selleckchem.com/products/bromodeoxyuridine-brdu.html","C9H11BrN2O5","free base","5-Bromo-2'-deoxyuridine, BUdR","OCC1OC(CC1O)N2C=C(Br)C(=O)NC2=O",-1.232,3,3,2]
["S7921","DEL-22379","h5","L6200-20","in 10mM DMSO","ERK","MAPK","DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.",444.53,"181223-80-3",{"v":89,"d":"89.00"},200.21,"<1","N/A","http://selleckchem.com/products/del-22379.html","C26H28N4O3","free base","N/A","COC1=CC2=C([NH]C=C2C=C3C(=O)NC4=CC=C(NC(=O)CCN5CCCCC5)C=C34)C=C1",{"v":3.3,"d":"3.300"},3,3,6]
["S7923","SH5-07 (SH-5-07)","a6","L6200-20","in 10mM DMSO","STAT","JAK/STAT","SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.",625.61,"1456632-41-9",{"v":100,"d":"100.00"},159.84,"<1","N/A","http://selleckchem.com/products/sh5-07.html","C29H28F5N3O5S","free base","N/A","CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)NO)[S](=O)(=O)C4=C(F)C(=C(F)C(=C4F)F)F",5.606,4,1,9]
["S7931","STF-31","b6","L6200-20","in 10mM DMSO","GLUT","Metabolism","STF-31 is a selective glucose transporter GLUT1 inhibitor.",423.53,"724741-75-7",{"v":85,"d":"85.00"},200.69,"<1","N/A","http://selleckchem.com/products/stf-31.html","C23H25N3O3S","free base","N/A","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3",3.359,4,2,7]
["S7933","VR23","c6","L6200-20","in 10mM DMSO","Proteasome","Proteases","VR23 is a potent proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes, and caspase-like proteasomes, respectively.",477.88,"1624602-30-7",{"v":31,"d":"31.00"},64.87,"<1","N/A","http://selleckchem.com/products/vr23.html","C19H16ClN5O6S","free base","N/A","[O-][N+](=O)C1=CC=C(C(=C1)[N+]([O-])=O)[S](=O)(=O)N2CCN(CC2)C3=CC=NC4=CC(=CC=C34)Cl",3.215,3,0,5]
["S7935","Y-39983 HCl","d6","L6200-20","in 10mM DMSO","ROCK","Cell Cycle","Y-39983 HCl (Y-33075) is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.",353.25,"173897-44-4",{"v":63,"d":"63.00"},178.34,{"v":63,"d":"63.00"},178.34,"http://selleckchem.com/products/y-39983-hcl.html","C16H16N4O.2HCl","dihydrochloride","Y-33075 HCl","Cl.Cl.CC(N)C1=CC=C(C=C1)C(=O)NC2=C3C=C[NH]C3=NC=C2",2.204,2,3,3]
["S7936","Belumosudil (KD025)","e6","L6200-20","in 10mM DMSO","ROCK","Cell Cycle","Belumosudil (KD025, SLx-2119) is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nM, respectively. Phase 2.",452.51,"911417-87-3",{"v":90,"d":"90.00"},198.89,"<1","N/A","http://selleckchem.com/products/kd025-(slx-2119).html","C26H24N6O2","free base","SLx-2119","CC(C)NC(=O)COC1=CC(=CC=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C([NH]N=C5)C=C4",{"v":4.51,"d":"4.510"},5,3,7]
["S7937","Nemiralisib","f6","L6200-20","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).",440.54,"1254036-71-9",{"v":88,"d":"88.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk2269557.html","C26H28N6O","free base","GSK2269557","CC(C)N1CCN(CC1)CC2=CN=C(O2)C3=CC(=CC4=C3C=N[NH]4)C5=CC=CC6=C5C=C[NH]6",3.943,3,2,5]
["S7938","GSK2292767","g6","L6200-20","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GSK2292767 is a potent and selective PI3Kδ inhibitor.",512.58,"1254036-66-2",{"v":100,"d":"100.00"},195.09,"<1","N/A","http://selleckchem.com/products/gsk2292767.html","C24H28N6O5S","free base","N/A","COC1=C(N[S](C)(=O)=O)C=C(C=N1)C2=CC3=C(C=N[NH]3)C(=C2)C4=NC=C(CN5CC(C)OC(C)C5)O4",1.692,8,2,7]
["S7943","O4I1","h6","L6200-20","in 10mM DMSO","OCT","Transmembrane Transporters","O4I1 is a potent Oct3/4 inducer.",{"v":253.3,"d":"253.30"},"175135-47-4",{"v":51,"d":"51.00"},201.34,"<1","N/A","http://selleckchem.com/products/o4i1.html","C16H15NO2","free base","N/A","COC1=CC=C(COC2=CC=C(CC#N)C=C2)C=C1",3.294,2,0,5]
["S7944","O4I2","a7","L6200-20","in 10mM DMSO","OCT","Transmembrane Transporters","O4I2 is a potent Oct3/4 inducer, which is suitable for iPSC generation.",282.75,"165682-93-9",{"v":56,"d":"56.00"},198.05,"<1","N/A","http://selleckchem.com/products/o4i2.html","C12H11ClN2O2S","free base","N/A","CCOC(=O)C1=CSC(=N1)NC2=CC=C(Cl)C=C2",3.674,3,1,5]
["S7946","KC7F2","b7","L6200-20","in 10mM DMSO","HIF","Angiogenesis","KC7F2 is a selective HIF-1α translation inhibitor with IC50 of 20 μM in a cell-based assay.",570.38,"927822-86-4",{"v":100,"d":"100.00"},175.32,"<1","N/A","http://selleckchem.com/products/kc7f2.html","C16H16Cl4N2O4S4","free base","N/A","ClC1=CC(=C(Cl)C=C1)[S](=O)(=O)NCCSSCCN[S](=O)(=O)C2=CC(=CC=C2Cl)Cl",5.162,4,2,11]
["S7947","PX-12","c7","L6200-20","in 10mM DMSO","COVID-19,Thioredoxin","Metabolism","PX-12 (DB05448, 1-methyl propyl 2-imidazolyl disulfide) is a potent thioredoxin-1 (Trx-1) inhibitor by irreversibly thioalkylation of Cys73 of Trx-1. Phase 2.",188.31,"141400-58-0",{"v":38,"d":"38.00"},201.79,"<1","N/A","http://selleckchem.com/products/px-12.html","C7H12N2S2","free base","DB05448, 1-methyl propyl 2-imidazolyl disulfide","CCC(C)SSC1=NC=C[NH]1",2.641,1,1,4]
["S7948","MRT67307 HCl","d7","L6200-20","in 10mM DMSO","Autophagy,IκB/IKK,TBK1,ULK","NF-κB","MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.","464.6 (free-base)","1781882-89-0",{"v":92,"d":"92.00"},198.02,{"v":92,"d":"92.00"},198.02,"https://www.selleckchem.com/products/mrt67307-hcl.html","C26H36N6O2.xHCl","hydrochloride","N/A","O=C(NCCCNC1=NC(=NC=C1C2CC2)NC3=CC(=CC=C3)CN4CCOCC4)C5CCC5",4.257,4,3,11]
["S7949","MRT68921 HCl","e7","L6200-20","in 10mM DMSO","Autophagy,ULK","Autophagy","MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.","434.58 (free base)","2070014-87-6",{"v":10,"d":"10.00"},23.01,"<1","N/A","http://selleckchem.com/products/mrt68921.html","C25H34N6O.xHCl","hydrochloride","N/A","CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C4CC4)C(=N3)NCCCNC(=O)C5CCC5",4.644,3,3,9]
["S7951","Ochromycinone (STA-21)","f7","L6200-20","in 10mM DMSO","STAT","JAK/STAT","Ochromycinone (STA-21) is a selective STAT3 inhibitor.",306.31,"111540-00-2",{"v":21,"d":"21.00"},68.56,"<1","N/A","http://selleckchem.com/products/sta-21.html","C19H14O4","free base","N/A","CC1CC(=O)C2=C(C1)C=CC3=C2C(=O)C4=C(C(=CC=C4)O)C3=O",3.339,3,1,0]
["S7953","ETC-1002","g7","L6200-20","in 10mM DMSO","AMPK,ATP-citrate lyase,LDL","PI3K/Akt/mTOR","ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).",344.49,"738606-46-7",{"v":68,"d":"68.00"},197.39,"<1","N/A","http://selleckchem.com/products/etc-1002.html","C19H36O5","free base","Bempedoic acid, ESP-55016","CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O",{"v":5.18,"d":"5.180"},2,1,14]
["S7954","CP21R7 (CP21)","h7","L6200-20","in 10mM DMSO","GSK-3,Wnt/beta-catenin","Stem Cells & Wnt","CP21R7 (CP21) is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.",317.34,"125314-13-8",{"v":63,"d":"63.00"},198.53,"<1","N/A","http://selleckchem.com/products/cp21r7-cp21.html","C19H15N3O2","free base","N/A","C[N]1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CC=CC(=C4)N",2.315,2,2,2]
["S7955","EPI-001","a8","L6200-20","in 10mM DMSO","Androgen Receptor,PPAR","Endocrinology & Hormones","EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator.",394.89,"227947-06-0",{"v":79,"d":"79.00"},200.06,"<1","N/A","http://selleckchem.com/products/epi-001.html","C21H27ClO5","free base","N/A","CC(C)(C1=CC=C(OCC(O)CO)C=C1)C2=CC=C(OCC(O)CCl)C=C2",3.334,2,3,10]
["S7958","Lificiguat (YC-1)","b8","L6200-20","in 10mM DMSO","Guanylate Cyclase,HIF","Angiogenesis","Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).",304.34,"170632-47-0",{"v":60,"d":"60.00"},197.15,"<1","N/A","http://selleckchem.com/products/lificiguat-yc-1.html","C19H16N2O2","free base","N/A","OCC1=CC=C(O1)C2=N[N](CC3=CC=CC=C3)C4=C2C=CC=C4",4.078,2,1,4]
["S7959","SIS3 HCl","c8","L6200-20","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.",489.99,"521984-48-5",{"v":97,"d":"97.00"},197.96,"<1","N/A","https://www.selleckchem.com/products/sis3-hcl.html","C28H27N3O3.HCl","hydrochloride","N/A","Cl.COC1=CC2=C(CN(CC2)C(=O)/C=C/C3=C([N](C)C4=NC=CC=C34)C5=CC=CC=C5)C=C1OC",5.076,4,0,5]
["S7963","TIC10 (ONC201)","d8","L6200-20","in 10mM DMSO","Akt,Apoptosis related,ERK,TNF-alpha","PI3K/Akt/mTOR","TIC10 (ONC201) inactivates Akt and ERK to induce TNF-related apoptosis-inducing ligand (TRAIL) through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.",386.49,"1616632-77-9",{"v":77,"d":"77.00"},199.23,"<1","N/A","http://selleckchem.com/products/tic-10.html","C24H26N4O","free base","ONC201","CC1=CC=CC=C1CN2C(=O)C3=C(CCN(CC4=CC=CC=C4)C3)N5CCN=C25",3.212,2,0,4]
["S7964","PLX7904","e8","L6200-20","in 10mM DMSO","Raf","MAPK","PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.",512.53,"1393465-84-3",{"v":100,"d":"100.00"},195.11,"<1","N/A","http://selleckchem.com/products/plx7904.html","C24H22F2N6O3S","free base","PB04","CCN(C)[S](=O)(=O)NC1=CC=C(F)C(=C1F)C(=O)C2=C[NH]C3=NC=C(C=C23)C4=CN=C(N=C4)C5CC5",2.291,6,2,8]
["S7966","AZD8835","f8","L6200-20","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).",469.54,"1620576-64-8",{"v":93,"d":"93.00"},198.07,"<1","N/A","http://selleckchem.com/products/azd8835.html","C22H31N9O3","free base","N/A","CC[N]1N=C(N=C1C2=CN=C(N)C(=N2)C3=NN=C(O3)C(C)(C)C)C4CCN(CC4)C(=O)CCO",0.942,8,2,7]
["S7975","Favipiravir (T-705)","g8","L6200-20","in 10mM DMSO","COVID-19,DNA/RNA Synthesis,Influenza Virus","DNA Damage/DNA Repair","Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.",{"v":157.1,"d":"157.10"},"259793-96-9",{"v":31,"d":"31.00"},197.33,{"v":5,"d":"5.00"},31.83,"http://selleckchem.com/products/favipiravir-t-705.html","C5H4FN3O2","free base","N/A","NC(=O)C1=NC(=CN=C1O)F",-0.157,3,2,1]
["S7977","Napabucasin (BBI608)","h8","L6200-20","in 10mM DMSO","STAT","JAK/STAT","Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.",240.21,"83280-65-3",{"v":10,"d":"10.00"},41.63,"<1","N/A","http://selleckchem.com/products/napabucasin.html","C14H8O4","free base","BBI608","CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O",2.234,4,0,1]
["S7979","FG-2216","a9","L6200-20","in 10mM DMSO","HIF","Angiogenesis","FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2. Phase 2.",280.66,"223387-75-5",{"v":56,"d":"56.00"},199.53,"<1","N/A","http://selleckchem.com/products/fg-2216.html","C12H9ClN2O4","free base","N/A","OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2C(=N1)Cl",1.337,3,2,3]
["S7980","VPS34-IN1","b9","L6200-20","in 10mM DMSO","Autophagy,PI3K","PI3K/Akt/mTOR","Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates autophagy.",425.91,"1383716-33-3",{"v":85,"d":"85.00"},199.57,"<1","N/A","http://selleckchem.com/products/vps34-in1.html","C21H24ClN7O","free base","Vps34-IN-1","CC(C)(O)CNC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC(=C4)Cl",3.672,5,2,8]
["S7983","A-196","c9","L6200-20","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.",359.25,"1982372-88-2",{"v":15,"d":"15.00"},41.75,"<1","N/A","http://selleckchem.com/products/a-196.html","C18H16Cl2N4","free base","N/A","ClC1=C(Cl)C=C2C(=C1)C(=NN=C2C3=CC=NC=C3)NC4CCCC4",4.995,3,1,3]
["S7992","LDC4297 (LDC044297)","d9","L6200-20","in 10mM DMSO","CDK","Cell Cycle","LDC4297 is a novel CDK7 inhibitor (IC50=0.13±0.06 nM for CDK7 versus IC50s between 10 nM and 10,000 nM for all other analyzed CDKs).",432.52,"1453834-21-3",{"v":86,"d":"86.00"},198.83,{"v":27,"d":"27.00"},62.42,"http://selleckchem.com/products/ldc4297-ldc044297.html","C23H28N8O","free base","N/A","CC(C)C1=C2N=C(OC3CCCNC3)N=C(NCC4=CC=CC=C4[N]5C=CC=N5)[N]2N=C1",3.928,5,2,7]
["S7995","Ripasudil (K-115) hydrochloride dihydrate","e9","L6200-20","in 10mM DMSO","ROCK","Cell Cycle","Ripasudil (K-115) hydrochloride dihydrate is a potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.",395.88,"887375-67-9",{"v":26,"d":"26.00"},65.68,{"v":79,"d":"79.00"},199.56,"http://selleckchem.com/products/ripasudil-k-115.html","C15H18FN3O2S.ClH.2H2O","Hydrochloride dihydrate","N/A","O.O.Cl.CC1CNCCCN1[S](=O)(=O)C2=CC=CC3=CN=CC(=C23)F",0.739,3,1,2]
["S7998","Entrectinib (RXDX-101)","f9","L6200-20","in 10mM DMSO","ALK,Autophagy,ROS1,Trk receptor","Protein Tyrosine Kinase","Entrectinib (RXDX-101, NMS-E628) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.",560.64,"1108743-60-7",{"v":100,"d":"100.00"},178.37,"<1","N/A","http://selleckchem.com/products/entrectinib-rxdx-101.html","C31H34F2N6O2","free base","NMS-E628","CN1CCN(CC1)C2=CC=C(C(=O)NC3=N[NH]C4=C3C=C(CC5=CC(=CC(=C5)F)F)C=C4)C(=C2)NC6CCOCC6",4.952,3,3,7]
["S7999","SKF96365","g9","L6200-20","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8000","Tenovin-1","h9","L6200-20","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).",369.48,"380315-80-0",{"v":74,"d":"74.00"},200.28,"<1","N/A","http://selleckchem.com/products/tenovin-1.html","C20H23N3O2S","free base","N/A","CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",4.287,2,3,6]
["S8001","Ricolinostat (ACY-1215)","a10","L6200-20","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","Ricolinostat (ACY-1215, Rocilinostat) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Ricolinostat (ACY-1215) suppresses cell proliferation and promotes apoptosis. Phase 2.",{"v":433.5,"d":"433.50"},"1316214-52-4",{"v":86,"d":"86.00"},198.39,"<1","N/A","http://selleckchem.com/products/rocilinostat-acy-1215.html","C24H27N5O3","free base","Rocilinostat","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",3.917,4,2,11]
["S8002","GSK2636771","b10","L6200-20","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3Kβ with >900-fold selectivity over PI3Kα/PI3Kγ and >10-fold over PI3Kδ. Sensitive to PTEN null cell lines.",433.42,"1372540-25-4",{"v":28,"d":"28.00"},{"v":64.6,"d":"64.60"},"<1","N/A","http://selleckchem.com/products/gsk2636771.html","C22H22F3N3O3","free base","N/A","CC1=NC2=C(C=C(C=C2[N]1CC3=CC=CC(=C3C)C(F)(F)F)N4CCOCC4)C(O)=O",4.303,3,0,5]
["S8003","PQ 401","c10","L6200-20","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.",341.79,"196868-63-0",{"v":32,"d":"32.00"},93.62,"<1","N/A","http://selleckchem.com/products/pq-401.html","C18H16ClN3O2","free base","N/A","COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(=C2)C)C=C(Cl)C=C1",3.639,3,2,3]
["S8004","ZM 39923 HCl","d10","L6200-20","in 10mM DMSO","JAK","JAK/STAT","ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.",367.91,"1021868-92-7",{"v":30,"d":"30.00"},81.54,"<1","N/A","http://selleckchem.com/products/zm-39923-hcl.html","C23H25NO.HCl","HCl","N/A","Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC3=CC=CC=C3",5.424,1,0,7]
["S8005","SMI-4a","e10","L6200-20","in 10mM DMSO","Pim","JAK/STAT","SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.",273.23,"438190-29-5",{"v":55,"d":"55.00"},{"v":201.3,"d":"201.30"},"<1","N/A","http://selleckchem.com/products/smi-4a.html","C11H6F3NO2S","free base","TCS PIM-1 4a","FC(F)(F)C1=CC(=CC=C1)\\C=C2/SC(=O)NC2=O",2.884,2,1,2]
["S8006","BIX 01294","f10","L6200-20","in 10mM DMSO","Autophagy,G9a/GLP,Histone Methyltransferase,NSD","Epigenetics","BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.",600.02,"1392399-03-9",{"v":98,"d":"98.00"},163.33,{"v":98,"d":"98.00"},163.33,"http://selleckchem.com/products/bix-01294.html","C28H38N6O2.3HCl","trihydrochloride","N/A","Cl.Cl.Cl.COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)CC4=CC=CC=C4)N5CCCN(C)CC5",5.246,4,1,7]
["S8007","VE-821","g10","L6200-20","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.",368.41,"1232410-49-9",{"v":74,"d":"74.00"},200.86,"<1","N/A","http://selleckchem.com/products/ve-821.html","C18H16N4O3S","Free Base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)C2=CN=C(N)C(=N2)C(=O)NC3=CC=CC=C3",2.007,5,2,4]
["S8018","Nirogacestat (PF-03084014)","h10","L6200-20","in 10mM DMSO","Apoptosis related,Secretase","Proteases","Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.",489.64,"1290543-63-3",{"v":97,"d":"97.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pf-03084014-pf-3084014.html","C27H41F2N5O","free base","PF-3084014","CCCC(NC1CCC2=CC(=CC(=C2C1)F)F)C(=O)NC3=C[N](C=N3)C(C)(C)CNCC(C)(C)C",5.042,2,3,11]
["S8019","Capivasertib (AZD5363)","a11","L6200-20","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.",428.92,"1143532-39-1",{"v":86,"d":"86.00"},{"v":200.5,"d":"200.50"},"<1","N/A","http://selleckchem.com/products/azd5363.html","C21H25ClN6O2","free base","N/A","NC1(CCN(CC1)C2=NC=NC3=C2C=C[NH]3)C(=O)NC(CCO)C4=CC=C(Cl)C=C4",1.317,3,4,6]
["S8020","GW0742","b11","L6200-20","in 10mM DMSO","PPAR","Metabolism","GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.",471.49,"317318-84-6",{"v":94,"d":"94.00"},199.37,"<1","N/A","http://selleckchem.com/products/gw0742.html","C21H17F4NO3S2","free base","N/A","CC1=CC(=CC=C1OCC(O)=O)SCC2=C(C)N=C(S2)C3=CC=C(C(=C3)F)C(F)(F)F",5.795,3,0,8]
["S8025","GSK3787","c11","L6200-20","in 10mM DMSO","PPAR","Metabolism","GSK3787 is a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ.",392.78,"188591-46-0",{"v":79,"d":"79.00"},201.13,"<1","N/A","http://selleckchem.com/products/gsk3787.html","C15H12ClF3N2O3S","free base","N/A","FC(F)(F)C1=CC=C(N=C1)[S](=O)(=O)CCNC(=O)C2=CC=C(Cl)C=C2",3.207,4,1,6]
["S8029","WY-14643 (Pirinixic Acid)","d11","L6200-20","in 10mM DMSO","PPAR","Metabolism","WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM.",{"v":323.8,"d":"323.80"},"50892-23-4",{"v":64,"d":"64.00"},197.65,"<1","N/A","http://selleckchem.com/products/wy-14643-pirinixic-acid.html","C14H14ClN3O2S","free base","NSC 310038","CC1=C(C)C(=CC=C1)NC2=NC(=NC(=C2)Cl)SCC(O)=O",{"v":4.53,"d":"4.530"},3,1,5]
["S8036","Butein","e11","L6200-20","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.",272.25,"487-52-5",{"v":55,"d":"55.00"},202.02,"<1","N/A","http://selleckchem.com/products/butein.html","C15H12O5","free base","N/A","OC1=CC(=C(C=C1)C(=O)\\C=C\\C2=CC(=C(O)C=C2)O)O",2.734,1,4,3]
["S8037","Necrostatin-1","f11","L6200-20","in 10mM DMSO","Apoptosis related,Autophagy,IDO/TDO,RIP kinase,TNF-alpha","Apoptosis","Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.",259.33,"4311-88-0",{"v":51,"d":"51.00"},196.66,"<1","N/A","http://selleckchem.com/products/necrostatin-1.html","C13H13N3OS","free base","Nec-1","CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S",2.472,1,2,2]
["S8038","UPF 1069","g11","L6200-20","in 10mM DMSO","PARP","DNA Damage/DNA Repair","UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.",279.29,"1048371-03-4",{"v":56,"d":"56.00"},200.51,"<1","N/A","http://selleckchem.com/products/upf-1069.html","C17H13NO3","free base","N/A","O=C(COC1=C2C=CNC(=O)C2=CC=C1)C3=CC=CC=C3",1.966,3,1,4]
["S8039","Zelavespib (PU-H71)","h11","L6200-20","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Zelavespib (PU-H71, NSC 750424) is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.",512.37,"873436-91-0",{"v":100,"d":"100.00"},195.17,{"v":34,"d":"34.00"},66.36,"http://selleckchem.com/products/pu-h71.html","C18H21IN6O2S","free base","NSC 750424","CC(C)NCCC[N]1C(=NC2=C(N)N=CN=C12)SC3=CC4=C(OCO4)C=C3I",3.162,5,2,7]
["S8040","GDC-0349","a2","L6200-21","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.",452.55,"1207360-89-1",{"v":91,"d":"91.00"},201.08,"<1","N/A","http://selleckchem.com/products/gdc-0349.html","C24H32N6O3","free base","RG-7603","CCNC(=O)NC1=CC=C(C=C1)C2=NC(=C3CCN(CC3=N2)C4COC4)N5CCOCC5C",1.982,5,2,5]
["S8043","Scriptaid","b2","L6200-21","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Scriptaid (GCK 1026) is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.",326.35,"287383-59-9",{"v":65,"d":"65.00"},199.17,"<1","N/A","http://selleckchem.com/products/scriptaid.html","C18H18N2O4","free base","GCK 1026","ONC(=O)CCCCCN1C(=O)C2=C3C(=CC=C2)C=CC=C3C1=O",2.119,3,1,6]
["S8044","BMS-345541","c2","L6200-21","in 10mM DMSO","IκB/IKK","NF-κB","BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.",255.32,"445430-58-0",{"v":9,"d":"9.00"},35.25,"<1","N/A","http://selleckchem.com/products/bms-345541.html","C14H17N5","free base","N/A","CC1=CC=C2N=C(NCCN)C3=NC=C(C)[N]3C2=C1",1.472,2,2,3]
["S8047","Dynasore","d2","L6200-21","in 10mM DMSO","Autophagy,Dynamin,HSV","Cytoskeletal Signaling","Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV).",322.31,"304448-55-3",{"v":64,"d":"64.00"},198.57,"<1","N/A","http://selleckchem.com/products/dynasore.html","C18H14N2O4","free base","N/A","OC1=C(O)C=C(C=C1)\\C=N\\NC(=O)C2=C(O)C=C3C=CC=CC3=C2",2.865,2,4,3]
["S8048","Venetoclax (ABT-199)","e2","L6200-21","in 10mM DMSO","Autophagy,Bcl-2","Apoptosis","Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.",868.44,"1257044-40-8",{"v":100,"d":"100.00"},115.15,"<1","N/A","http://selleckchem.com/products/abt-199.html","C45H50ClN7O7S","free base","GDC-0199","CC1(C)CCC(=C(C1)C2=CC=C(Cl)C=C2)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)N[S](=O)(=O)C5=CC=C(NCC6CCOCC6)C(=C5)[N+]([O-])=O)OC7=CN=C8[NH]C=CC8=C7",{"v":7.94,"d":"7.940"},6,3,13]
["S8049","Tubastatin A","f2","L6200-21","in 10mM DMSO","Apoptosis related,Autophagy,HDAC","Epigenetics","Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.",{"v":335.4,"d":"335.40"},"1252003-15-8",{"v":67,"d":"67.00"},199.76,"<1","N/A","https://www.selleckchem.com/products/tubastatin-a.html","C20H21N3O2","N/A","N/A","CN1CCC2=C(C1)C3=C(C=CC=C3)[N]2CC4=CC=C(C=C4)C(=O)NO",3.081,1,1,3]
["S8050","ETP-46464","g2","L6200-21","in 10mM DMSO","ATM/ATR,mTOR","PI3K/Akt/mTOR","ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.",470.52,"1345675-02-6",{"v":6,"d":"6.00"},12.75,"<1","N/A","http://selleckchem.com/products/etp-46464.html","C30H22N4O2","free base","N/A","CC(C)(C#N)C1=CC=C(C=C1)N2C(=O)OCC3=C2C4=C(C=CC(=C4)C5=CN=C6C=CC=CC6=C5)N=C3",5.813,4,0,3]
["S8057","Pacritinib (SB1518)","h2","L6200-21","in 10mM DMSO","FLT3,JAK","JAK/STAT","Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.",472.58,"937272-79-2",{"v":11,"d":"11.00"},23.28,"<1","N/A","http://selleckchem.com/products/pacritinib-sb1518.html","C28H32N4O3","free base","N/A","C1CCN(C1)CCOC2=CC=C3NC4=NC=CC(=N4)C5=CC(=CC=C5)COC\\C=C\\COCC2=C3",4.547,5,1,4]
["S8058","Riviciclib hydrochloride (P276-00)","a3","L6200-21","in 10mM DMSO","Apoptosis related,CDK","Cell Cycle","Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Riviciclib hydrochloride (P276-00) induces apoptosis. Phase 2/3.",{"v":438.3,"d":"438.30"},"920113-03-7",{"v":88,"d":"88.00"},200.78,{"v":88,"d":"88.00"},200.78,"http://selleckchem.com/products/p276-00.html","C21H20ClNO5.HCl","hydrochloride","N/A","Cl.CN1CCC(C1CO)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=C(Cl)C=CC=C4",{"v":3.49,"d":"3.490"},2,3,3]
["S8065","Nutlin-3b","b3","L6200-21","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8068","Chaetocin","c3","L6200-21","in 10mM DMSO","Anti-infection,G9a/GLP,Histone Methyltransferase,Thioredoxin Reductase","Epigenetics","Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).",696.84,"28097-03-2",{"v":100,"d":"100.00"},{"v":143.5,"d":"143.50"},"<1","N/A","http://selleckchem.com/products/chaetocin.html","C30H28N6O6S4","free base","N/A","CN1C(=O)C23CC4(C(NC5=C4C=CC=C5)N2C(=O)C1(CO)SS3)C67CC89SSC(CO)(N(C)C8=O)C(=O)N9C6NC%10=C7C=CC=C%10",1.621,4,4,3]
["S8071","UNC0638","d3","L6200-21","in 10mM DMSO","Antiviral,G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.",509.73,"1255580-76-7",{"v":100,"d":"100.00"},196.18,{"v":6,"d":"6.00"},11.77,"http://selleckchem.com/products/unc0638.html","C30H47N5O2","free base","N/A","COC1=CC2=C(NC3CCN(CC3)C(C)C)N=C(N=C2C=C1OCCCN4CCCC4)C5CCCCC5",5.284,4,1,10]
["S8072","NSC 405020","e3","L6200-21","in 10mM DMSO","MMP","Proteases","NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.",260.16,"7497-07-6",{"v":52,"d":"52.00"},199.88,"<1","N/A","http://selleckchem.com/products/nsc-405020.html","C12H15Cl2NO","free base","N/A","CCCC(C)NC(=O)C1=CC=C(Cl)C(=C1)Cl",4.073,1,1,4]
["S8076","PluriSIn #1 (NSC 14613)","f3","L6200-21","in 10mM DMSO","SCD","Metabolism","PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.",213.24,"91396-88-2",{"v":43,"d":"43.00"},201.65,"<1","N/A","http://selleckchem.com/products/PluriSIn-1-nsc-14613.html","C12H11N3O","free base","N/A","O=C(NNC1=CC=CC=C1)C2=CC=NC=C2",1.486,2,2,3]
["S8077","RI-1","g3","L6200-21","in 10mM DMSO","RAD51","DNA Damage/DNA Repair","RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.",361.61,"415713-60-9",{"v":50,"d":"50.00"},138.27,"<1","N/A","http://selleckchem.com/products/ri-1.html","C14H11Cl3N2O3","free base","RAD51 inhibitor 1","ClC1=CC=C(C=C1Cl)N2C(=O)C(=C(N3CCOCC3)C2=O)Cl",2.544,3,0,2]
["S8078","Bardoxolone Methyl","h3","L6200-21","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8095","Tubercidin","a4","L6200-21","in 10mM DMSO","DNA/RNA Synthesis,Fungal","DNA Damage/DNA Repair","Tubercidin (7-deaza-adenosine), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhibits antifungal and antiviral activities.",266.25,"69-33-0",{"v":53,"d":"53.00"},199.06,"<1","N/A","http://selleckchem.com/products/tubercidin.html","C11H14N4O4","free base","7-deaza-adenosine","NC1=NC=NC2=C1C=C[N]2C3OC(CO)C(O)C3O",-1.103,3,4,2]
["S8096","Mirin","b4","L6200-21","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. Mirin inhibits MRN-dependent activation of ATM.",220.25,"1198097-97-0",{"v":44,"d":"44.00"},199.77,"<1","N/A","http://selleckchem.com/products/mirin.html","C10H8N2O2S","free base","N/A","OC1=CC=C(C=C1)\\C=C2/SC(=N)NC2=O",1.754,1,2,1]
["S8100","K03861","c4","L6200-21","in 10mM DMSO","CDK","Cell Cycle","K03861 (AUZ 454，AUZ454) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.",{"v":501.5,"d":"501.50"},"853299-07-7",{"v":100,"d":"100.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://selleckchem.com/products/k03861.html","C24H26F3N7O2","free base","AUZ 454，AUZ454","CN1CCN(CC1)CC2=CC=C(NC(=O)NC3=CC=C(OC4=NC(=NC=C4)N)C=C3)C=C2C(F)(F)F",3.591,4,3,7]
["S8101","CB-5083","d4","L6200-21","in 10mM DMSO","ATPase,p97","Transmembrane Transporters","CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.",413.47,"1542705-92-9",{"v":82,"d":"82.00"},198.32,"<1","N/A","http://selleckchem.com/products/cb-5083.html","C24H23N5O2","free base","N/A","CC1=CC2=C(C=CC=C2C(N)=O)[N]1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5",3.748,4,2,5]
["S8102","Z-VAD(OH)-FMK (Caspase Inhibitor VI)","e4","L6200-21","in 10mM DMSO","Caspase","Apoptosis","Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.",453.46,"161401-82-7",{"v":90,"d":"90.00"},198.47,"<1","N/A","http://selleckchem.com/products/z-vad(oh)-fmk.html","C21H28FN3O7","free base","N/A","CC(C)C(NC(=O)OCC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC(O)=O)C(=O)CF",1.246,6,3,13]
["S8106","NSC59984","f4","L6200-21","in 10mM DMSO","p53","Apoptosis","NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.",265.27,"803647-40-7",{"v":53,"d":"53.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/nsc59984.html","C12H15N3O4","free base","N/A","CN1CCN(CC1)C(=O)\\C=C\\C2=CC=C(O2)[N+]([O-])=O",1.083,2,0,3]
["S8111","GSK591","g4","L6200-21","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.",380.48,"1616391-87-7",{"v":76,"d":"76.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk591-epz015866-gsk3203591.html","C22H28N4O2","free base","EPZ015866, GSK3203591","OC(CNC(=O)C1=CC(=NC=C1)NC2CCC2)CN3CCC4=C(C3)C=CC=C4",2.467,2,3,7]
["S8112","MS023","h4","L6200-21","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.",{"v":287.4,"d":"287.40"},"1831110-54-3",{"v":57,"d":"57.00"},198.33,"<1","N/A","http://selleckchem.com/products/ms023.html","C17H25N3O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[NH]C=C2CN(C)CCN",2.396,1,2,7]
["S8118","RHPS 4 methosulfate","a5","L6200-21","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.",458.48,"390362-78-4",{"v":91,"d":"91.00"},198.48,"<1","N/A","http://selleckchem.com/products/rhps4-nsc714187.html","C22H17F2N2.CH3O4S","methyl sulfate","NSC714187","CO[S]([O-])(=O)=O.CN1C2=CC=C(F)C=C2C3=[N+](C)C4=C(C=C(F)C=C4)C5=CC(=CC1=C35)C",3.363,1,0,1]
["S8124","BMS-582949","b5","L6200-21","in 10mM DMSO","p38 MAPK","MAPK","BMS-582949 (PS540446) is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13nM,inhibiting both p38 kinase activity and activation of p38.",406.48,"623152-17-0",{"v":81,"d":"81.00"},199.27,"<1","N/A","http://selleckchem.com/products/bms-582949.html","C22H26N6O2","free base","PS540446","CCCNC(=O)C1=C[N]2N=CN=C(NC3=CC(=CC=C3C)C(=O)NC4CC4)C2=C1C",3.269,4,3,7]
["S8125","Pamapimod","c5","L6200-21","in 10mM DMSO","p38 MAPK","MAPK","Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.",406.38,"449811-01-2",{"v":81,"d":"81.00"},199.32,"<1","N/A","http://selleckchem.com/products/pamapimod-r-1503-ro4402257.html","C19H20F2N4O4","free base","R-1503,Ro4402257","CN1C(=O)C(=CC2=CN=C(NC(CCO)CCO)N=C12)OC3=C(F)C=C(F)C=C3",1.298,4,3,8]
["S8132","Deguelin","d5","L6200-21","in 10mM DMSO","Akt,PI3K","PI3K/Akt/mTOR","Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an  PI3K/AKT Inhibitor.",394.42,"522-17-8",{"v":78,"d":"78.00"},197.76,"<1","N/A","http://selleckchem.com/products/deguelin.html","C23H22O6","free base","(-)-Deguelin, (-)-cis-Deguelin","COC1=CC2=C(C=C1OC)C3C(CO2)OC4=C5C=CC(C)(C)OC5=CC=C4C3=O",3.567,6,0,2]
["S8136","Sivelestat (ONO-5046)","e5","L6200-21","in 10mM DMSO","Serine Protease","Proteases","Sivelestat (ONO5046, LY544349, EI546) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.",434.46,"127373-66-4",{"v":86,"d":"86.00"},197.95,"<1","N/A","http://selleckchem.com/products/sivelestat-ono-5046.html","C20H22N2O7S","Free Base","ONO5046, LY544349, EI546","CC(C)(C)C(=O)OC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C(=O)NCC(O)=O",2.321,6,2,9]
["S8144","Halofuginone","f5","L6200-21","in 10mM DMSO","DNA/RNA Synthesis,TGF-beta/Smad","DNA Damage/DNA Repair","Halofuginone (RU-19110) is the competitively inhibitor of  prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.",414.68,"55837-20-2",{"v":20,"d":"20.00"},48.23,"<1","N/A","http://selleckchem.com/products/halofuginone.html","C16H17BrClN3O3","free base","RU-19110","OC1CCCNC1CC(=O)CN2C=NC3=CC(=C(Cl)C=C3C2=O)Br",1.648,3,2,4]
["S8147","MS049","g5","L6200-21","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively.",321.29,"2095432-59-8",{"v":56,"d":"56.00"},{"v":174.3,"d":"174.30"},{"v":56,"d":"56.00"},{"v":174.3,"d":"174.30"},"http://selleckchem.com/products/ms049.html","C15H26Cl2N2O","dihydrochloride","N/A","Cl.Cl.CNCCN1CCC(CC1)OCC2=CC=CC=C2",2.111,1,1,6]
["S8148","PD0166285","h5","L6200-21","in 10mM DMSO","Apoptosis related,Chk,Wee1","Cell Cycle","PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.",512.43,"185039-89-8",{"v":100,"d":"100.00"},195.15,"<1","N/A","http://selleckchem.com/products/pd0166285.html","C26H27Cl2N5O2","free base","N/A","CCN(CC)CCOC1=CC=C(NC2=NC3=C(C=N2)C=C(C(=O)N3C)C4=C(Cl)C=CC=C4Cl)C=C1",5.917,4,1,9]
["S8149","NSC348884","a6","L6200-21","in 10mM DMSO","Apoptosis related,p53","Apoptosis","NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.",636.79,"81624-55-7",{"v":100,"d":"100.00"},157.04,"<1","N/A","http://selleckchem.com/products/nsc348884.html","C38H40N10","free base","N/A","CC1=CC2=C(C=C1)N=C(CN(CCN(CC3=NC4=C([NH]3)C=C(C)C=C4)CC5=NC6=C([NH]5)C=C(C)C=C6)CC7=NC8=C([NH]7)C=C(C)C=C8)[NH]2",7.572,4,4,11]
["S8155","RSL3","b6","L6200-21","in 10mM DMSO","Ferroptosis,Peroxidases","Metabolism","RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.",440.88,"1219810-16-8",{"v":88,"d":"88.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://selleckchem.com/products/rsl3.html","C23H21ClN2O5","free base","(1S,3R)-RSL3","COC(=O)C1CC2=C([NH]C3=C2C=CC=C3)C(N1C(=O)CCl)C4=CC=C(C=C4)C(=O)OC",3.558,5,1,6]
["S8157","GDC-0326","c6","L6200-21","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","GDC-0326 is a potent and selective inhibitor of PI3Kα with Ki value of 0.2 nM; remarkably selective over the other class I isoforms in enzymatic assays.",382.42,"1282514-88-8",{"v":76,"d":"76.00"},198.73,"<1","N/A","http://selleckchem.com/products/gdc-0326.html","C19H22N6O3","free base","N/A","CC(C)[N]1N=CN=C1C2=C[N]3CCOC4=CC(=CC=C4C3=N2)OC(C)C(N)=O",2.017,6,1,5]
["S8161","ON123300","d6","L6200-21","in 10mM DMSO","AMPK,CDK,c-RET,FGFR,PDGFR,Src","Cell Cycle","ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn, respectively.",429.52,"1357470-29-1",{"v":29,"d":"29.00"},67.52,"<1","N/A","http://selleckchem.com/products/on123300.html","C24H27N7O","free base","N/A","CN1CCN(CC1)C2=CC=C(NC3=NC=C4C=C(C#N)C(=O)N(C5CCCC5)C4=N3)C=C2",{"v":3.65,"d":"3.650"},3,1,4]
["S8163","Paxalisib (GDC-0084)","e6","L6200-21","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.",382.42,"1382979-44-3",{"v":8,"d":"8.00"},20.92,"<1","N/A","http://selleckchem.com/products/gdc-0084.html","C18H22N8O2","free base","RG7666","CC1(C)OCC[N]2C3=C(N=C12)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",0.588,7,1,2]
["S8165","Cucurbitacin B","f6","L6200-21","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from Cucurbitaceae plant species, is a long-term anticancer agent by disruption of microtubule polymerization.",{"v":558.7,"d":"558.70"},"6199-67-3",{"v":100,"d":"100.00"},178.99,"<1","N/A","http://selleckchem.com/products/cucurbitacin-b.html","C32H46O8","free base","N/A","CC(=O)OC(C)(C)/C=C/C(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C",2.312,5,2,6]
["S8171","Daprodustat (GSK1278863)","g6","L6200-21","in 10mM DMSO","HIF","Angiogenesis","Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.",393.43,"960539-70-2",{"v":10,"d":"10.00"},25.42,"<1","N/A","http://selleckchem.com/products/daprodustat.html","C19H27N3O6","free base","N/A","OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C3CCCCC3)C1=O",1.747,5,1,5]
["S8173","Verubecestat (MK-8931) Trifluoroacetate","h6","L6200-21","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.",523.43,"2095432-65-6",{"v":81,"d":"81.00"},154.75,"<1","N/A","http://selleckchem.com/products/verubecestat-mk-8931.html","C19H18F5N5O5S","Trifluoroacetat","MK-8931","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3.OC(=O)C(F)(F)F",2.198,5,2,4]
["S8174","VO-Ohpic trihydrate","a7","L6200-21","in 10mM DMSO","PTEN","PI3K/Akt/mTOR","VO-Ohpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.",{"v":415.2,"d":"415.20"},"476310-60-8",{"v":72,"d":"72.00"},173.41,"<1","N/A","http://selleckchem.com/products/vo-ohpic.html","C12H9N2O8V.3H2O.H","trihydrate","N/A","O.O.O.OC1=CC=CN|2=C1C(=O)O[VH]3|2(O)(=O)OC(=O)C4=NC=CC=C4O3",-0.342,7,1,0]
["S8177","BH3I-1","b7","L6200-21","in 10mM DMSO","Bcl-2","Apoptosis","BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.",400.31,"300817-68-9",{"v":64,"d":"64.00"},159.88,"<1","N/A","http://selleckchem.com/products/bh3i-1.html","C15H14BrNO3S2","free base","N/A","CC(C)C(N1C(=S)S\\C(=C/C2=CC=C(Br)C=C2)C1=O)C(O)=O",4.604,2,0,4]
["S8178","Wnt agonist 1","c7","L6200-21","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.",386.83,"2095432-75-8",{"v":77,"d":"77.00"},199.05,"<1","N/A","http://selleckchem.com/products/wnt-agonist-1.html","C19H18N4O3.HCl","hydrochloride","BML-284 HCL, BML-284 hydrochloride, AMBMP hydrochloride, AMBMP HCL","Cl.COC1=CC(=CC=C1)C2=NC(=NC(=C2)NCC3=CC=C4OCOC4=C3)N",3.837,5,2,5]
["S8179","BI-7273","d7","L6200-21","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","BI-7273 is a potent, selective, and cell-permeable BRD9 BD inhibitor with IC50s of 19 nM and 117 nM for BRD9 and BRD7 respectively in alpha assay.",353.41,"1883429-21-7",{"v":70,"d":"70.00"},198.07,"<1","N/A","http://selleckchem.com/products/bi-7273.html","C20H23N3O3","free base","N/A","COC1=C(CN(C)C)C(=CC(=C1)C2=CN(C)C(=O)C3=C2C=CN=C3)OC",1.301,4,0,5]
["S8180","PF-CBP1 HCl","e7","L6200-21","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.",525.08,"2070014-93-4",{"v":100,"d":"100.00"},190.45,{"v":100,"d":"100.00"},190.45,"http://selleckchem.com/products/pf-cbp1.html","C29H36N4O3.HCl","Hydrochloride","N/A","Cl.CCCOC1=CC=C(CCC2=NC3=CC(=CC=C3[N]2CCN4CCOCC4)C5=C(C)ON=C5C)C=C1",5.432,5,0,10]
["S8181","SBI-0640756","f7","L6200-21","in 10mM DMSO","eIF","Cell Cycle","SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.",404.82,"1821280-29-8",{"v":80,"d":"80.00"},197.62,"<1","N/A","http://selleckchem.com/products/sbi-0640756.html","C23H14ClFN2O2","free base","N/A","FC1=CC(=CN=C1)\\C=C\\C(=O)C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(=C4)Cl",4.273,3,1,4]
["S8190","CPI-637","g7","L6200-21","in 10mM DMSO","Epigenetic Reader Domain,Histone Acetyltransferase","Epigenetics","CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM and 0.051μM for CBP and EP300 respectively in TR-FRET assay. It is highly selective against other bromodomains, displaying substantial biochemical activity only against BRD9.",386.45,"1884712-47-3",{"v":27,"d":"27.00"},69.87,"<1","N/A","http://selleckchem.com/products/cpi-637.html","C22H22N6O","free base","N/A","CC1CC(=O)NC2=C(N1)C(=CC=C2)C3=CC4=C(C=C3)[N](C)N=C4C5=C[N](C)N=C5",3.035,3,2,2]
["S8193","Lanabecestat (AZD3293)","h7","L6200-21","in 10mM DMSO","BACE","Neuronal Signaling","Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki  of 0.4 nM.",412.53,"1383982-64-6",{"v":82,"d":"82.00"},198.77,"<1","N/A","http://selleckchem.com/products/azd3293-ly3314814.html","C26H28N4O","free base","LY3314814","COC1CCC2(CC1)CC3=C(C=C(C=C3)C4=CN=CC(=C4)C#CC)C25N=C(C)C(=N5)N",3.882,4,1,3]
["S8194","umbralisib (TGR-1202)","a8","L6200-21","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Umbralisib (TGR-1202, Rp-5264), a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively.",571.55,"1532533-67-7",{"v":100,"d":"100.00"},174.96,"<1","N/A","http://selleckchem.com/products/tgr-1202.html","C31H24F3N5O3","free base","Rp-5264","CC(C)OC1=C(F)C=C(C=C1)C2=N[N](C(C)C3=C(C4=CC(=CC=C4)F)C(=O)C5=CC(=CC=C5O3)F)C6=C2C(=NC=N6)N",6.393,6,1,6]
["S8195","Oclacitinib maleate","b8","L6200-21","in 10mM DMSO","JAK","JAK/STAT","Oclacitinib maleate (PF-03394197) is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. It does not inhibit a panel of 38 non-JAK kinases.",453.51,"1640292-55-2",{"v":90,"d":"90.00"},198.45,{"v":18,"d":"18.00"},39.69,"http://selleckchem.com/products/oclacitinib-maleate.html","C15H23N5O2S.C4H4O4","maleate","PF-03394197","CN[S](=O)(=O)CC1CCC(CC1)N(C)C2=C3C=C[NH]C3=NC=N2.OC(=O)\\C=C/C(O)=O",1.758,6,2,7]
["S8200","MK-4101","c8","L6200-21","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.",493.47,"935273-79-3",{"v":98,"d":"98.00"},198.59,"<1","N/A","http://selleckchem.com/products/mk-4101.html","C24H24F5N5O","free base","N/A","C[N]1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(F)(F)C5)C6=CC=CC=C6C(F)(F)F",4.784,5,0,5]
["S8208","Hydroxyfasudil (HA-1100) HCl","d8","L6200-21","in 10mM DMSO","ROCK","Cell Cycle","Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively.",343.83,"155558-32-0 (HCl salt)",{"v":68,"d":"68.00"},197.77,{"v":60,"d":"60.00"},{"v":174.5,"d":"174.50"},"http://selleckchem.com/products/hydroxyfasudil-ha-1100.html","C14H17N3O3S.HCl.xH2O","hydrochloride","N/A","Cl.O=C1NC=CC2=C1C=CC=C2[S](=O)(=O)N3CCCNCC3",0.443,3,2,2]
["S8209","HLCL-61 HCL","e8","L6200-21","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.",380.91,"1158279-20-9",{"v":76,"d":"76.00"},199.52,"<1","N/A","http://selleckchem.com/products/hlcl-61-hydrochloride.html","C23H24N2O.HCl","hydrochloride","HLCL61","Cl.CC[N]1C2=CC=CC=C2C3=C1C=CC(=C3)CNCC4=C(OC)C=CC=C4",5.364,1,1,6]
["S8215","BAY 1217389","f8","L6200-21","in 10mM DMSO","MPS1","Cell Cycle","BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.",{"v":561.5,"d":"561.50"},"1554458-53-5",{"v":100,"d":"100.00"},178.09,"<1","N/A","http://selleckchem.com/products/bay-1217389.html","C27H24F5N5O3","free base","N/A","COC1=CC=C(OC2=N[N]3C(=CN=C3C(=C2)NCCC(F)(F)F)C4=CC(=C(C=C4)C(=O)NC5CC5)C)C(=C1F)F",5.255,5,2,10]
["S8228","NT157","g8","L6200-21","in 10mM DMSO","IGF-1R","Protein Tyrosine Kinase","NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate), has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.",412.26,"1384426-12-3",{"v":82,"d":"82.00"},{"v":198.9,"d":"198.90"},"<1","N/A","http://selleckchem.com/products/nt157.html","C16H14BrNO5S","free base","N/A","OC1=CC(=CC(=C1O)O)CNC(=S)/C=C/C2=CC(=C(O)C(=C2)Br)O",3.721,0,6,5]
["S8234","RS-1","h8","L6200-21","in 10mM DMSO","CRISPR/Cas9,RAD51","DNA Damage/DNA Repair","RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.",524.23,"312756-74-4",{"v":100,"d":"100.00"},190.76,"<1","N/A","http://selleckchem.com/products/rs-1.html","C20H16Br2N2O3S","free base","N/A","BrC1=CC=C(NC(=O)C2=CC=C(Br)C(=C2)[S](=O)(=O)NCC3=CC=CC=C3)C=C1",4.606,3,2,6]
["S8236","MK-886","a9","L6200-21","in 10mM DMSO","FLAP","Immunology & Inflammation","MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.",472.08,"118414-82-7",{"v":94,"d":"94.00"},199.12,"<1","N/A","http://selleckchem.com/products/mk-886-l-663-536.html","C27H34ClNO2S","free base","L-663,536","CC(C)C1=CC=C2[N](CC3=CC=C(Cl)C=C3)C(=C(SC(C)(C)C)C2=C1)CC(C)(C)C(O)=O",8.114,1,0,8]
["S8237","IC261","b9","L6200-21","in 10mM DMSO","Casein Kinase","Metabolism","IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM.",311.33,"186611-52-9",{"v":62,"d":"62.00"},199.15,"<1","N/A","http://selleckchem.com/products/ic261.html","C18H17NO4","free base","SU-5607","COC1=CC(=C(\\C=C/2C(=O)NC3=C2C=CC=C3)C(=C1)OC)OC",2.681,4,1,4]
["S8240","SMER28","c9","L6200-21","in 10mM DMSO","Autophagy","Autophagy","SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells.",264.12,"307538-42-7",{"v":52,"d":"52.00"},196.88,"<1","N/A","http://selleckchem.com/products/smer28.html","C11H10BrN3","free base","N/A","BrC1=CC=C2N=CN=C(NCC=C)C2=C1",3.101,2,1,3]
["S8244","Etomoxir sodium salt","d9","L6200-21","in 10mM DMSO","Apoptosis related,CPT,Transferase","Metabolism","Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.",320.74,"828934-41-4",{"v":64,"d":"64.00"},199.54,{"v":64,"d":"64.00"},199.54,"http://selleckchem.com/products/etomoxir-na-salt.html","C15H18ClO4.Na","sodium salt","(R)-(+)-Etomoxir sodium salt","[Na]OC(=O)C1(CCCCCCOC2=CC=C(Cl)C=C2)CO1",3.847,4,0,10]
["S8245","Thiomyristoyl","e9","L6200-21","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.",581.85,"1429749-41-6",{"v":100,"d":"100.00"},171.87,"<1","N/A","http://selleckchem.com/products/thiomyristoyl.html","C34H51N3O3S","free base","TM","CCCCCCCCCCCCCC(=S)NCCCCC(NC(=O)OCC1=CC=CC=C1)C(=O)NC2=CC=CC=C2",9.441,3,3,24]
["S8248","IQ-1","f9","L6200-21","in 10mM DMSO","PP2A,Wnt/beta-catenin","Stem Cells & Wnt","IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.",362.42,"331001-62-8",{"v":72,"d":"72.00"},198.66,"<1","N/A","http://selleckchem.com/products/iq-1.html","C21H22N4O2","free base","N/A","CC(=O)C1=CC=C(C=C1)N=N\\C(C(N)=O)=C2\\NC(C)(C)CC3=C2C=CC=C3",3.005,4,2,4]
["S8249","HPI-4 (Ciliobrevin A)","g9","L6200-21","in 10mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","HPI-4 (Ciliobrevin A, Hedgehog Pathway Inhibitor 4) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.",358.18,"302803-72-1",{"v":71,"d":"71.00"},198.22,"<1","N/A","http://selleckchem.com/products/hpi-4-ciliobrevin-a.html","C17H9Cl2N3O2","free base","Hedgehog Pathway Inhibitor 4","ClC1=CC(=C(C=C1)C(=O)\\C(C#N)=C/2NC(=O)C3=C(N2)C=CC=C3)Cl",3.847,2,2,2]
["S8253","CCT245737","h9","L6200-21","in 10mM DMSO","Chk","Cell Cycle","CCT245737 (SRA737, PNT-737) is an orally active CHK1 inhibitor with The IC50 of 1.4 nM. It exhibits >1,000-fold selectivity against CHK2 and CDK1.",379.34,"1489389-18-5",{"v":75,"d":"75.00"},197.71,"<1","N/A","http://selleckchem.com/products/cct245737.html","C16H16F3N7O","free base","SRA737, PNT-737","FC(F)(F)C1=CN=C(NC2=CN=C(C=N2)C#N)C=C1NCC3CNCCO3",{"v":1.46,"d":"1.460"},4,3,6]
["S8261","GSK583","a10","L6200-21","in 10mM DMSO","Interleukins,RIP kinase,TNF-alpha","Apoptosis","GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.",398.45,"1346547-00-9",{"v":79,"d":"79.00"},198.27,"<1","N/A","http://selleckchem.com/products/gsk583.html","C20H19FN4O2S","free base","N/A","CC(C)(C)[S](=O)(=O)C1=CC=C2N=CC=C(NC3=N[NH]C4=C3C=C(F)C=C4)C2=C1",4.412,4,2,4]
["S8265","GSK6853","b10","L6200-21","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.",409.48,"1910124-24-1",{"v":81,"d":"81.00"},197.81,"<1","N/A","http://selleckchem.com/products/gsk6853.html","C22H27N5O3","free base","N/A","COC1=CC=CC=C1C(=O)NC2=CC3=C(C=C2N4CCNCC4C)N(C)C(=O)N3C",1.834,3,2,4]
["S8270","SRT2183","c10","L6200-21","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.",468.57,"1001908-89-9",{"v":93,"d":"93.00"},198.48,"<1","N/A","http://selleckchem.com/products/srt2183.html","C27H24N4O2S","free base","N/A","OC1CCN(C1)CC2=CSC3=NC(=C[N]23)C4=C(NC(=O)C5=CC6=C(C=CC=C6)C=C5)C=CC=C4",{"v":3.6,"d":"3.600"},2,2,5]
["S8276","FCCP","d10","L6200-21","in 10mM DMSO","ATPase,OXPHOS","Apoptosis","FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.",254.17,"370-86-5",{"v":50,"d":"50.00"},196.72,"<1","N/A","http://selleckchem.com/products/fccp.html","C10H5F3N4O","free base","Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone","FC(F)(F)OC1=CC=C(NN=C(C#N)C#N)C=C1",3.924,2,1,4]
["S8279","(±)-Shikonin","e10","L6200-21","in 10mM DMSO","Anti-infection,Chloride Channel,COVID-19,NF-κB,PKM,Proteasome,TNF-alpha","Metabolism","(±)-Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.",{"v":288.3,"d":"288.30"},"54952-43-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/shikonin.html","C16H16O5","free base","Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["S8280","IMR-1","f10","L6200-21","in 10mM DMSO","Notch","Stem Cells & Wnt","IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.",353.41,"310456-65-6",{"v":70,"d":"70.00"},198.07,"<1","N/A","http://selleckchem.com/products/imr-1.html","C15H15NO5S2","free base","N/A","CCOC(=O)COC1=CC=C(C=C1OC)\\C=C2/SC(=S)NC2=O",2.864,5,1,7]
["S8286","MKC-3946","g10","L6200-21","in 10mM DMSO","IRE1","ER stress & UPR","MKC3946 is a potent and soluble IRE1α endoribonuclease domain inhibitor which triggered modest growth inhibition in multiple myeloma cell lines, without toxicity in normal mononuclear cells.",380.46,"1093119-54-0",{"v":38,"d":"38.00"},99.88,"<1","N/A","http://selleckchem.com/products/mkc-3946.html","C21H20N2O3S","free base","N/A","CN1CCN(CC1)C(=O)C2=CC=C(S2)C3=CC4=CC=C(O)C(=C4C=C3)C=O",{"v":3.39,"d":"3.390"},2,1,3]
["S8287","CPI-455 HCl","h10","L6200-21","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","CPI-455  HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.",314.77,"2095432-28-1",{"v":10,"d":"10.00"},31.77,"<1","N/A","https://www.selleckchem.com/products/cpi-455-hcl.html","C16H15ClN4O","hydrochloride","N/A","Cl.CC(C)C1=C(NC2=C(C=N[N]2C1=O)C#N)C3=CC=CC=C3",3.195,2,1,2]
["S8288","VLX1570","a11","L6200-21","in 10mM DMSO","DUB","Ubiquitin","VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.",469.39,"1431280-51-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://selleckchem.com/products/vlx1570.html","C23H17F2N3O6","free base","N/A","[O-][N+](=O)C1=C(F)C=CC(=C1)\\C=C2/CCN(C\\C(=C/C3=CC=C(F)C(=C3)[N+]([O-])=O)C2=O)C(=O)C=C",4.385,2,0,5]
["S8289","NQDI-1","b11","L6200-21","in 10mM DMSO","ASK","Apoptosis","NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.",319.31,"175026-96-7",{"v":21,"d":"21.00"},65.77,"<1","N/A","http://selleckchem.com/products/nqdi-1.html","C19H13NO4","free base","N/A","CCOC(=O)C1=C2C3=C(C=CC=C3)C(=O)C4=C2C(=CC=C4)NC1=O",2.469,4,1,3]
["S8291","Atractylenolide I","c11","L6200-21","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.",{"v":230.3,"d":"230.30"},"73069-13-3",{"v":46,"d":"46.00"},199.74,"<1","N/A","http://selleckchem.com/products/atractylenolide-i.html","C15H18O2","free base","N/A","CC1=C2CC3C(=C)CCCC3(C)C=C2OC1=O",3.323,2,0,0]
["S8296","dBET1","d11","L6200-21","in 10mM DMSO","Epigenetic Reader Domain,PROTAC","Epigenetics","dBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment.",785.27,"1799711-21-9",{"v":100,"d":"100.00"},127.34,"<1","N/A","http://www.selleck.cn/products/bet1.html","C38H37ClN8O7S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C6CCC(=O)NC6=O)C5=O)N=C2C7=CC=C(Cl)C=C7)C",2.976,10,3,12]
["S8298","CZ415","e11","L6200-21","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.",459.56,"1429639-50-8",{"v":91,"d":"91.00"},198.02,"<1","N/A","http://selleckchem.com/products/cz415.html","C22H29N5O4S","free base","N/A","CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C[S](=O)(=O)C3(C)C)C(=N2)N4CCOCC4C",{"v":2.2,"d":"2.200"},6,2,4]
["S8299","HA15","f11","L6200-21","in 10mM DMSO","HSP (HSP90)","ER stress & UPR","HA15 is a molecule that targets specifically HSPA5 (Heat shock 70kDa protein 5) also known as BiP (Immunoglobulin heavy-chain-binding protein) or Grp78 (glucose-regulated protein 78). HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.",466.58,"1609402-14-3",{"v":93,"d":"93.00"},199.32,"<1","N/A","http://selleckchem.com/products/ha15.html","C23H22N4O3S2","free base","N/A","CN(C)C1=CC=CC2=C1C=CC=C2[S](=O)(=O)NC3=CC(=CC=C3)C4=CSC(=N4)NC(C)=O",3.452,4,2,6]
["S8305","TRC051384","g11","L6200-21","in 10mM DMSO","HSP (HSP90)","Metabolism","TRC051384 is an inducer of heat shock protein 70 (HSP70) and potent anti-inflammatory agent.",465.54,"867164-40-7",{"v":93,"d":"93.00"},199.77,"<1","N/A","http://selleckchem.com/products/trc051384.html","C25H31N5O4","free base","N/A","O=C(NCCN1CCOCC1)NC2=CC=C(C=C2)C(=O)\\C=C\\C3=CC=CC(=N3)N4CCOCC4",2.311,5,2,8]
["S8317","3BDO","h11","L6200-21","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.",327.33,"890405-51-3",{"v":65,"d":"65.00"},198.58,"<1","N/A","http://selleckchem.com/products/3bdo.html","C18H17NO5","free base","3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one","[O-][N+](=O)C1=C(OCC2CC(CC3=CC=CC=C3)C(=O)O2)C=CC=C1",3.782,3,0,6]
["S8318","Alantolactone","a2","L6200-22","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","Alantolactone (helenin, helenine, Eupatal), a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction.",232.32,"546-43-0",{"v":46,"d":"46.00"},{"v":198,"d":"198.00"},"<1","N/A","http://selleckchem.com/products/alantolactone.html","C15H20O2","free base","helenin, helenine, Eupatal","CC1CCCC2(C)CC3OC(=O)C(=C)C3C=C12",3.311,2,0,0]
["S8319","7,8-Dihydroxyflavone","b2","L6200-22","in 10mM DMSO","Trk receptor","Protein Tyrosine Kinase","7,8-Dihydroxyflavone (7,8-DHF) acts as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).",254.24,"38183-03-8",{"v":50,"d":"50.00"},196.66,"<1","N/A","http://selleckchem.com/products/7-8-dihydroxyflavone.html","C15H10O4","free base","7,8-DHF","OC1=CC=C2C(=O)C=C(OC2=C1O)C3=CC=CC=C3",2.652,2,2,1]
["S8320","SKL2001","c2","L6200-22","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.",286.29,"909089-13-0",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/skl2001.html","C14H14N4O3","free base","N/A","O=C(NCCC[N]1C=CN=C1)C2=NOC(=C2)C3=CC=CO3",0.929,5,1,6]
["S8322","Samotolisib (LY3023414)","d2","L6200-22","in 10mM DMSO","DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.",406.48,"1386874-06-1",{"v":47,"d":"47.00"},115.63,"<1","N/A","http://selleckchem.com/products/ly3023414.html","C23H26N4O3","free base","GTPL8918","COC(C)CN1C(=O)N(C)C2=C1C3=CC(=CC=C3N=C2)C4=CC(=CN=C4)C(C)(C)O",1.883,4,0,5]
["S8323","ITSA-1 (ITSA1)","e2","L6200-22","in 10mM DMSO","HDAC","Epigenetics","ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors.",292.12,"200626-61-5",{"v":58,"d":"58.00"},198.55,"<1","N/A","http://selleckchem.com/products/itsa-1-itsa1.html","C13H7Cl2N3O","free base","N/A","ClC1=CC=C(C(=C1)Cl)C(=O)[N]2N=NC3=CC=CC=C23",4.418,3,0,1]
["S8326","Saccharin 1-methylimidazole (SMI)","f2","L6200-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Saccharin 1-methylimidazole (SMI) is considered a general-purpose activator for DNA and RNA synthesis.",265.29,"482333-74-4",{"v":53,"d":"53.00"},199.78,{"v":53,"d":"53.00"},199.78,"http://selleckchem.com/products/saccharin-1-methylimidazole-smi.html","C7H5NO3S.C4H6N2","free base","N/A","C[NH+]1C=CN=C1.[O-]C2=N[S](=O)(=O)C3=CC=CC=C23",-1.429,4,0,0]
["S8327","KYA1797K","g2","L6200-22","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).",442.51,"1956356-56-1",{"v":29,"d":"29.00"},65.54,{"v":29,"d":"29.00"},65.54,"http://selleckchem.com/products/kya1797k.html","C17H11N2O6S2.K","potassium salt","N/A","[O-][N+](=O)C1=CC=C(C=C1)C2=CC=C(O2)\\C=C3/SC(=S)N(CCC(=O)O[K])C3=O",3.967,4,0,7]
["S8328","CeMMEC1 HCl","h2","L6200-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM).",{"v":372.8,"d":"372.80"},"2095432-53-2",{"v":23,"d":"23.00"},{"v":61.7,"d":"61.70"},"<1","N/A","http://selleckchem.com/products/cemmec1.html","C19H17ClN2O4","hydrochloride","N/A","Cl.CN1C=C(C(=O)NC2=CC3=C(OCCO3)C=C2)C4=CC=CC=C4C1=O",1.845,4,1,2]
["S8329","CeMMEC13","a3","L6200-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).",336.34,"1790895-25-8",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cemmec13.html","C19H16N2O4","free base","N/A","CN1C(=O)C=C(C(=O)NC2=CC3=C(OCCO3)C=C2)C4=CC=CC=C14",1.989,4,1,2]
["S8330","Eganelisib (IPI-549)","b3","L6200-22","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Eganelisib (IPI-549) is a potent inhibitor of PI3K-γ with >100-fold selectivity over other lipid and protein kinases. The biochemical IC50 for PI3K-γ is 16 nM.",528.56,"1693758-51-8",{"v":100,"d":"100.00"},189.19,"<1","N/A","http://selleckchem.com/products/ipi-549.html","C30H24N8O2","free base","N/A","CC(NC(=O)C1=C2N=CC=C[N]2N=C1N)C3=CC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)C#CC6=C[N](C)N=C6",2.732,5,2,6]
["S8334","XMU-MP-1","c3","L6200-22","in 10mM DMSO","MST","Hippo","XMU-MP-1 is an inhibitor of MST1/2 with IC50 values of 71.1±12.9 nM and 38.1±6.9 nM against MST1 and MST2, respectively.",416.48,"2061980-01-4",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/xmu-mp-1.html","C17H16N6O3S2","free base","N/A","CN1C(=O)C2=C(C=CS2)N(C)C3=NC(=NC=C13)NC4=CC=C(C=C4)[S](N)(=O)=O",2.236,5,2,3]
["S8335","PF-06409577","d3","L6200-22","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.",341.79,"1467057-23-3",{"v":68,"d":"68.00"},198.95,"<1","N/A","http://selleckchem.com/products/pf-06409577.html","C19H16ClNO3","free base","N/A","OC(=O)C1=C[NH]C2=CC(=C(C=C12)C3=CC=C(C=C3)C4(O)CCC4)Cl",4.133,1,1,3]
["S8337","1400W 2HCl","e3","L6200-22","in 10mM DMSO","NOS","Immunology & Inflammation","1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS).",250.17,"214358-33-5",{"v":35,"d":"35.00"},{"v":139.9,"d":"139.90"},{"v":35,"d":"35.00"},{"v":139.9,"d":"139.90"},"http://selleckchem.com/products/1400w.html","C10H15N3.2HCl","dihydrochloride","N-(3-(Aminomethyl)benzyl)acetamidine","Cl.Cl.CC(=N)NCC1=CC=CC(=C1)CN",0.881,0,2,4]
["S8339","Miransertib (ARQ 092) HCl","f3","L6200-22","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.",468.98,"1313883-00-9",{"v":75,"d":"75.00"},159.92,"<1","N/A","http://selleckchem.com/products/arq-092.html","C27H25ClN6","hydrochloride","Miransertib","Cl.NC1=NC=CC=C1C2=NC3=CC=C(N=C3[N]2C4=CC=C(C=C4)C5(N)CCC5)C6=CC=CC=C6",{"v":4.98,"d":"4.980"},3,2,4]
["S8340","SGC2085","g3","L6200-22","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.",312.41,"1821908-48-8",{"v":62,"d":"62.00"},198.46,"<1","N/A","http://selleckchem.com/products/sgc2085.html","C19H24N2O2","free base","N/A","CC(N)C(=O)NCC1=CC=C(OC2=CC(=CC(=C2)C)C)C(=C1)C",3.498,2,2,5]
["S8352","PT2385","h3","L6200-22","in 10mM DMSO","HIF","Epigenetics","PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.",383.34,"1672665-49-4",{"v":77,"d":"77.00"},200.87,"<1","N/A","http://www.selleckchem.com/products/pt2385.html","C17H12F3NO4S","Free Base","N/A","C[S](=O)(=O)C1=CC=C(OC2=CC(=CC(=C2)F)C#N)C3=C1C(O)C(F)(F)C3",2.732,3,1,3]
["S8353","Lirametostat (CPI-1205)","a4","L6200-22","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.",518.57,"1621862-70-1",{"v":100,"d":"100.00"},192.84,"<1","N/A","http://selleckchem.com/products/cpi-1205.html","C27H33F3N4O3","free base","CPI 1205, CPI1205","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCN(CC3)CC(F)(F)F)C4=C2C=CC=C4)C(=O)NC(=C1)C",3.348,3,2,8]
["S8358","WNK463","b4","L6200-22","in 10mM DMSO","Serine/threonin kinase","Apoptosis","WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4) with IC50 of 5nM, 1nM, 6nM, and 9nM.",463.46,"2012607-27-9",{"v":92,"d":"92.00"},198.51,"<1","N/A","http://selleckchem.com/products/wnk463.html","C21H24F3N7O2","free base","N/A","CC(C)(C)NC(=O)C1=CN=C[N]1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F",2.173,6,1,6]
["S8359","UNC3866","c4","L6200-22","in 10mM DMSO","Histone Methyltransferase","Epigenetics","UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains.",795.02,"1872382-47-2",{"v":100,"d":"100.00"},125.78,"<1","N/A","http://selleckchem.com/products/unc3866.html","C43H66N6O8","free base","N/A","CCN(CC)CCCCC(NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C(=O)NC(CO)C(=O)OC",4.291,7,6,25]
["S8363","NMS-P118","d4","L6200-22","in 10mM DMSO","PARP","DNA Damage/DNA Repair","NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles, showing 150-fold selectivity for PARP-1 over PARP-2 (Kd 0.009 μM vs 1.39 μM, respectively).",395.42,"1262417-51-5",{"v":24,"d":"24.00"},60.69,"<1","N/A","http://selleckchem.com/products/nms-p118.html","C20H24F3N3O2","free base","N/A","NC(=O)C1=CC(=CC2=C1C(=O)N(C2)C3CCN(CC3)C4CCC(F)(F)CC4)F",1.422,2,1,3]
["S8365","Apoptozole","e4","L6200-22","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.",625.56,"1054543-47-3",{"v":100,"d":"100.00"},159.86,"<1","N/A","http://selleckchem.com/products/apoptozole.html","C33H25F6N3O3","free base","Apoptosis Activator VII","COC1=CC=C(C=C1)C2=C([N](CC3=CC=C(C=C3)C(N)=O)C(=N2)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=CC=C(OC)C=C5",8.042,4,1,10]
["S8369","Lys05","f4","L6200-22","in 10mM DMSO","Autophagy","Autophagy","Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.",549.75,"1391426-24-6",{"v":9,"d":"9.00"},16.37,{"v":3,"d":"3.00"},5.46,"http://selleckchem.com/products/lys05.html","C23H23Cl2N5.3HCl","Trihydrochloride","N/A","Cl.Cl.Cl.CN(CCNC1=CC=NC2=C1C=CC(=C2)Cl)CCNC3=C4C=CC(=CC4=NC=C3)Cl",6.082,2,2,8]
["S8370","BGP-15 2HCl","g4","L6200-22","in 10mM DMSO","PARP","DNA Damage/DNA Repair","BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury.",351.27,"66611-37-8",{"v":70,"d":"70.00"},199.28,{"v":70,"d":"70.00"},199.28,"http://selleckchem.com/products/bgp-15.html","C14H22N4O2.2HCl","dihydrochloride","N/A","Cl.Cl.NC(=N\\OCC(O)CN1CCCCC1)/C2=CC=CN=C2",1.097,3,2,6]
["S8376","Rbin-1","h4","L6200-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.",256.33,"328023-11-6",{"v":23,"d":"23.00"},89.73,"<1","N/A","http://selleckchem.com/products/rbin-1.html","C13H12N4S","free base","Ribozinoindole-1","CC(=C)CSC1=NC2=C(N=N1)C3=CC=CC=C3[NH]2",{"v":3.83,"d":"3.830"},3,1,3]
["S8379","YU238259","a5","L6200-22","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.",459.95,"1943733-16-1",{"v":91,"d":"91.00"},197.85,"<1","N/A","http://selleckchem.com/products/yu238259.html","C22H22ClN3O4S","free base","N/A","COC1=CC=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NCCC3=CC=C(Cl)C=N3",3.076,5,2,9]
["S8387","MSC2530818","b5","L6200-22","in 10mM DMSO","CDK","Cell Cycle","MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.",340.81,"1883423-59-3",{"v":68,"d":"68.00"},199.52,"<1","N/A","http://selleckchem.com/products/msc2530818.html","C18H17ClN4O","free base","N/A","CC1=N[NH]C2=C1C=C(C=N2)C(=O)N3CCCC3C4=CC=C(Cl)C=C4",2.956,3,1,2]
["S8388","ML-7 HCl","c5","L6200-22","in 10mM DMSO","MLCK,PKA,PKC","Cytoskeletal Signaling","ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. ML-7 also inhibits PKA and PKC with Ki of 21 μM and 42 μM, respectively.",452.74,"110448-33-4",{"v":90,"d":"90.00"},198.79,"<1","N/A","http://selleckchem.com/products/ml-7.html","C15H17IN2O2S.HCl","hydrochloride","N/A","Cl.IC1=C2C=CC=C(C2=CC=C1)[S](=O)(=O)N3CCCNCC3",2.299,2,1,2]
["S8400","Mivebresib (ABBV-075)","d5","L6200-22","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain","Epigenetics","Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.",459.47,"1445993-26-9",{"v":91,"d":"91.00"},198.05,"<1","N/A","http://selleckchem.com/products/mivebresib-abbv-075.html","C22H19F2N3O4S","free base","N/A","CC[S](=O)(=O)NC1=CC(=C(OC2=C(F)C=C(F)C=C2)C=C1)C3=CN(C)C(=O)C4=C3C=C[NH]4",3.027,4,2,6]
["S8402","KRIBB11","e5","L6200-22","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","KRIBB11 abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. It is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1). KRIBB11 induces growth arrest and apoptosis.",284.27,"342639-96-7",{"v":3,"d":"3.00"},10.55,"<1","N/A","http://selleckchem.com/products/kribb11.html","C13H12N6O2","free base","N/A","CNC1=CC=C(C(=N1)NC2=CC=C3[NH]N=CC3=C2)[N+]([O-])=O",2.654,2,3,4]
["S8403","MX69","f5","L6200-22","in 10mM DMSO","MDM2/MDMX","Apoptosis","MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment.",474.57,"1005264-47-0",{"v":95,"d":"95.00"},200.18,"<1","N/A","http://selleckchem.com/products/mx69.html","C27H26N2O4S","free base","N/A","CC1=C(C)C=C(N[S](=O)(=O)C2=CC3=C(NC(C4CC=CC34)C5=CC=C(C=C5)C(O)=O)C=C2)C=C1",5.082,3,2,5]
["S8405","RRx-001","g5","L6200-22","in 10mM DMSO","Apoptosis related,Dehydrogenase","Metabolism","RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. RRx-001 triggers apoptosis and exhibits anticancer activity.",268.02,"925206-65-1",{"v":53,"d":"53.00"},197.75,"<1","N/A","http://selleckchem.com/products/rrx-001.html","C5H6BrN3O5","free base","N/A","[O-][N+](=O)C1(CN(C1)C(=O)CBr)[N+]([O-])=O",0.473,1,0,3]
["S8409","KG-501 (2-naphthol-AS-E-phosphate)","h5","L6200-22","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","KG-501 (2-naphthol-AS-E-phosphate) is a cAMP response element-binding protein (CREB) inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM). It also disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ≈90 μM, using concentrations of CREB that were within the linear range of the binding assay.",377.72,"18228-17-6",{"v":20,"d":"20.00"},52.95,"<1","N/A","http://www.selleckchem.com/products/kg-501-2-naphthol-as-e-phosphate.html","C17H13ClNO5P","Free Base","N/A","O[P](O)(=O)OC1=CC2=CC=CC=C2C=C1C(=O)NC3=CC=C(Cl)C=C3",3.691,2,1,4]
["S8419","Stenoparib (E7449)","a6","L6200-22","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.",317.34,"1140964-99-3",{"v":4,"d":"4.00"},{"v":12.6,"d":"12.60"},"<1","N/A","http://selleckchem.com/products/e7449.html","C18H15N5O","free base","2X-121, MGI25036","O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5",1.436,3,2,2]
["S8427","LTURM34","b6","L6200-22","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","LTURM34 is a specific DNA-PK inhibitor, 170-fold more selective for DNA-PK activity compared to PI3K activity, with IC50 value of 0.034 μM.",414.48,"1879887-96-3",{"v":82,"d":"82.00"},197.84,"<1","N/A","http://selleckchem.com/products/lturm34.html","C24H18N2O3S","free base","N/A","O=C1N=C(OC2=C1C=CC=C2C3=C4SC5=C(C=CC=C5)C4=CC=C3)N6CCOCC6",4.946,4,0,2]
["S8429","PNU-74654","c6","L6200-22","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4.",320.34,"113906-27-7",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/pnu-74654.html","C19H16N2O3","free base","N/A","CC1=CC=C(O1)/C=N/NC(=O)C2=CC=CC=C2OC3=CC=CC=C3",3.784,4,1,5]
["S8432","Troglitazone (CS-045)","d6","L6200-22","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,PPAR","Metabolism","Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced ferroptosis and lipid peroxidation in Pfa1 cells.",441.54,"97322-87-7",{"v":88,"d":"88.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/troglitazone-cs-045.html","C24H27NO5S","free base","Rezulin, Romglizone, Prelay, Romozin","CC1=C(O)C(=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C)C",5.682,4,2,5]
["S8433","NS-398 (NS398)","e6","L6200-22","in 10mM DMSO","COX","Neuronal Signaling","NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.",314.36,"123653-11-2",{"v":62,"d":"62.00"},197.23,"<1","N/A","http://selleckchem.com/products/ns-398-ns398.html","C13H18N2O5S","free base","N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide","C[S](=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O",2.477,3,1,5]
["S8434","B02","f6","L6200-22","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).",339.39,"1290541-46-6",{"v":67,"d":"67.00"},197.41,"<1","N/A","http://selleckchem.com/products/b02.html","C22H17N3O","free base","N/A","O=C1N(CC2=CC=CC=C2)C(=NC3=C1C=CC=C3)/C=C/C4=CC=CN=C4",{"v":3.6,"d":"3.600"},3,0,4]
["S8438","T-3775440 HCl","g6","L6200-22","in 10mM DMSO","Histone Demethylase,LSD1","Methylation","T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.",346.85,"1422535-52-1",{"v":69,"d":"69.00"},198.93,{"v":22,"d":"22.00"},63.43,"http://www.selleck.cn/products/t-3775440-hcl.html","C18H23ClN4O","HCl","N/A","Cl.C[N]1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4",2.262,2,2,6]
["S8439","Monastrol","h6","L6200-22","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) with an IC50 of 14μM, which is essential for maintaining separation of the half-spindles.",292.35,"329689-23-8",{"v":58,"d":"58.00"},198.39,"<1","N/A","http://selleckchem.com/products/monastrol.html","C14H16N2O3S","free base","(±)-Monastrol","CCOC(=O)C1=C(C)NC(=S)NC1C2=CC(=CC=C2)O",2.459,2,3,4]
["S8441","LW 6","a7","L6200-22","in 10mM DMSO","HIF","Angiogenesis","LW 6 (CAY10585, AC1-001) is a hypoxia-inducible factor 1(HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. LW6 inhibits HIF and MDH2 expression with IC50 values of 4.4 and 6.3 μM, respectively.",435.51,"934593-90-5",{"v":13,"d":"13.00"},29.85,"<1","N/A","http://selleckchem.com/products/lw-6.html","C26H29NO5","free base","CAY10585, AC1-001","COC(=O)C1=CC(=C(O)C=C1)NC(=O)COC2=CC=C(C=C2)[C]34CC5[CH2][CH](C[CH]([CH2]5)C3)C4",4.472,4,2,7]
["S8443","MK-8617","b7","L6200-22","in 10mM DMSO","HIF","Angiogenesis","MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.",443.45,"1187990-87-9",{"v":20,"d":"20.00"},{"v":45.1,"d":"45.10"},"<1","N/A","http://selleckchem.com/products/mk-8617.html","C24H21N5O4","free base","N/A","COC1=CC=C(C=C1)C(NC(=O)C2=C(O)N=C(N=C2)C3=NN=CC=C3)C4=CC=C(OC)C=C4",3.149,7,2,7]
["S8447","8-OH-DPAT (8-Hydroxy-DPAT)","c7","L6200-22","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.",247.38,"78950-78-4",{"v":49,"d":"49.00"},198.08,"<1","N/A","http://selleckchem.com/products/8-oh-dpat-8-hydroxy-dpat.html","C16H25NO","free base","N/A","CCCN(CCC)C1CCC2=CC=CC(=C2C1)O",4.287,0,1,5]
["S8448","ZINC00881524 (ROCK inhibitor)","d7","L6200-22","in 10mM DMSO","ROCK","Cell Cycle","ZINC00881524 is a ROCK inhibitor.",380.46,"557782-81-7",{"v":76,"d":"76.00"},199.76,"<1","N/A","http://selleckchem.com/products/zinc00881524-rock-inhibitor.html","C21H20N2O3S","free base","N/A","COC1=C(OC)C=C(CC(=O)NC2=NC3=C(CCC4=CC=CC=C34)S2)C=C1",4.031,4,1,5]
["S8456","VPS34 inhibitor 1 (Compound 19)","e7","L6200-22","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.",391.47,"1383716-46-8",{"v":78,"d":"78.00"},199.25,"<1","N/A","http://selleckchem.com/products/vps34-inhibitor-1.html","C21H25N7O","free base","PIK-III analogue","CC(C)(O)CNC1=NC=C(C(=N1)CC2CC2)C3=CC=NC(=N3)NC4=CC=NC=C4",2.798,5,2,8]
["S8460","Salermide","f7","L6200-22","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.",394.47,"1105698-15-4",{"v":78,"d":"78.00"},197.73,"<1","N/A","http://selleckchem.com/products/salermide.html","C26H22N2O2","free base","N/A","CC(C(=O)NC1=CC=CC(=C1)N=CC2=C(O)C=CC3=CC=CC=C23)C4=CC=CC=C4",5.374,2,2,5]
["S8464","Citarinostat (ACY-241)","g7","L6200-22","in 10mM DMSO","HDAC","Epigenetics","Citarinostat (ACY-241, HDAC-IN-2) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.",467.95,"1316215-12-9",{"v":41,"d":"41.00"},87.62,"<1","N/A","http://selleckchem.com/products/citarinostat-acy-241.html","C24H26ClN5O3","free base","HDAC-IN-2","ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=C(Cl)C=CC=C3",4.582,4,2,11]
["S8474","LF3","h7","L6200-22","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.",416.56,"664969-54-4",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/lf3.html","C20H24N4O2S2","free base","N/A","N[S](=O)(=O)C1=CC=C(NC(=S)N2CCN(CC2)C\\C=C\\C3=CC=CC=C3)C=C1",3.762,2,2,7]
["S8479","LLY-284","a8","L6200-22","in 10mM DMSO","PRMT","Epigenetics","LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.",342.35,"2226515-75-7",{"v":68,"d":"68.00"},198.63,"<1","N/A","https://www.selleckchem.com/products/lly-284.html","C17H18N4O4","free base","N/A","NC1=NC=NC2=C1C=C[N]2C3OC(C(O)C3O)C(O)C4=CC=CC=C4",0.509,3,4,3]
["S8481","SRT3025 HCl","b8","L6200-22","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.",{"v":606.2,"d":"606.20"},"2070015-26-6",{"v":100,"d":"100.00"},164.96,"<1","N/A","http://selleckchem.com/products/srt3025.html","C31H31N5O2S2.HCl","hydrochloride","N/A","Cl.COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=CC(=CN=C5S4)CN6CCCC6",5.849,5,1,10]
["S8483","CBL0137 HCl","c8","L6200-22","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8484","GSK2982772","d8","L6200-22","in 10mM DMSO","RIP kinase,TNF-alpha","Apoptosis","GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase (RIPK1) inhibitor with the IC50 value of 16 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.",{"v":377.4,"d":"377.40"},"1622848-92-3",{"v":75,"d":"75.00"},198.73,"<1","N/A","http://selleckchem.com/products/gsk2982772.html","C20H19N5O3","free base","N/A","CN1C(=O)C(COC2=CC=CC=C12)NC(=O)C3=N[NH]C(=N3)CC4=CC=CC=C4",1.639,5,2,4]
["S8489","GSK180736A (GSK180736)","e8","L6200-22","in 10mM DMSO","GRK","GPCR & G Protein","GSK180736A (GSK180736), developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.",365.36,"817194-38-0",{"v":73,"d":"73.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/gsk180736a.html","C19H16FN5O2","free base","N/A","CC1=C(C(NC(=O)N1)C2=CC=C(F)C=C2)C(=O)NC3=CC4=C([NH]N=C4)C=C3",1.843,3,4,3]
["S8493","PD-166866 (PD166866)","f8","L6200-22","in 10mM DMSO","FGFR","Angiogenesis","PD-166866 is a synthetic molecule inhibiting the tyrosin kinase action of FGFR1, shows a very high selectivity towards FGFR1 and inhibits the auto-phosphorylation activity of FGRF1.",396.44,"192705-79-6",{"v":14,"d":"14.00"},35.31,"<1","N/A","http://selleckchem.com/products/pd-166866.html","C20H24N6O3","free base","N/A","COC1=CC(=CC(=C1)C2=CC3=C(N=C(N)N=C3)N=C2NC(=O)NC(C)(C)C)OC",2.279,6,3,5]
["S8494","PF-06726304","g8","L6200-22","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM.",446.33,"1616287-82-1",{"v":10,"d":"10.00"},{"v":22.4,"d":"22.40"},"<1","N/A","http://selleckchem.com/products/pf-06726304.html","C22H21Cl2N3O3","free base","PF-6726304","CC1=CC(=C(CN2CCC3=C(Cl)C=C(C(=C3C2=O)Cl)C4=C(C)ON=C4C)C(=O)N1)C",3.398,4,1,3]
["S8495","WT161","h8","L6200-22","in 10mM DMSO","Apoptosis related,HDAC","Epigenetics","WT161 is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 values of 0.4 nM, 8.35 nM and 15.4 nM for HDAC6, HDAC1 and HDAC2, respectively; shown to have >100-fold selectivity over other HDACs. WT161 induces apoptosis.",458.55,"1206731-57-8",{"v":86,"d":"86.00"},187.55,"<1","N/A","http://selleckchem.com/products/wt161.html","C27H30N4O3","free base","N/A","ONC(=O)CCCCCCC(=O)N/N=C/C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=CC=C3",5.406,3,2,12]
["S8496","EED226","a9","L6200-22","in 10mM DMSO","Epigenetic Reader Domain,Histone Methyltransferase","Epigenetics","EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.",{"v":369.4,"d":"369.40"},"2083627-02-3",{"v":73,"d":"73.00"},197.62,"<1","N/A","http://selleckchem.com/products/eed226.html","C17H15N5O3S","free base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)C2=CN=C(NCC3=CC=CO3)[N]4C=NN=C24",2.136,6,1,5]
["S8502","TMP195","b9","L6200-22","in 10mM DMSO","HDAC","Epigenetics","TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with Ki of 59, 60, 26 and 15nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.",456.42,"1314891-22-9",{"v":91,"d":"91.00"},199.38,"<1","N/A","http://selleckchem.com/products/tmp195.html","C23H19F3N4O3","free base","TFMO 2","CC(C)(CNC(=O)C1=CC(=CC=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4",4.525,6,1,7]
["S8519","A-317491","c9","L6200-22","in 10mM DMSO","P2 Receptor","Neuronal Signaling","A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.",565.57,"475205-49-3",{"v":100,"d":"100.00"},176.81,"<1","N/A","http://selleckchem.com/products/a-317491.html","C33H27NO8","free base","N/A","OC(=O)C1=C(C=C(C(=O)N(CC2=CC(=CC=C2)OC3=CC=CC=C3)C4CCCC5=C4C=CC=C5)C(=C1)C(O)=O)C(O)=O",5.876,5,0,9]
["S8520","Senexin A","d9","L6200-22","in 10mM DMSO","CDK","Cell Cycle","Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.",274.32,"1366002-50-7",{"v":54,"d":"54.00"},196.85,"<1","N/A","http://selleckchem.com/products/senexin-a.html","C17H14N4","free base","N/A","N#CC1=CC=C2N=CN=C(NCCC3=CC=CC=C3)C2=C1",3.519,2,1,4]
["S8526","GDC-0575 (ARRY-575)","e9","L6200-22","in 10mM DMSO","Chk","Cell Cycle","GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2 nM.",378.27,"1196541-47-5",{"v":75,"d":"75.00"},198.27,"<1","N/A","http://www.selleckchem.com/products/gdc-0575.html","C16H20BrN5O","Free Base","RG7741","NC1CCCN(C1)C2=C(Br)C=NC3=C2C(=C[NH]3)NC(=O)C4CC4",1.621,2,3,3]
["S8534","Temuterkib (LY3214996)","f9","L6200-22","in 10mM DMSO","ERK","MAPK","Temuterkib (LY3214996) is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.",453.56,"1951483-29-6",{"v":27,"d":"27.00"},59.53,"<1","N/A","http://selleckchem.com/products/ly3214996.html","C22H27N7O2S","free base","N/A","C[N]1N=CC=C1NC2=NC(=CC=N2)C3=CC4=C(S3)C(C)(C)N(CCN5CCOCC5)C4=O",2.664,5,1,6]
["S8538","Ritlecitinib (PF-06651600)","g9","L6200-22","in 10mM DMSO","JAK","JAK/STAT","Ritlecitinib (PF-06651600) is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.",285.34,"1792180-81-4",{"v":57,"d":"57.00"},199.76,"N/A","N/A","http://selleckchem.com/products/pf-06651600.html","C15H19N5O","free base","N/A","CC1CCC(CN1C(=O)C=C)NC2=C3C=C[NH]C3=NC=N2",1.854,3,2,3]
["S8539","TAS-102","h9","L6200-22","in 10mM DMSO","DNA/RNA Synthesis,Thymidylate Synthase","DNA Damage/DNA Repair","TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.",435.76,"733030-01-8",{"v":100,"d":"100.00"},114.74,{"v":15,"d":"15.00"},17.21,"http://selleckchem.com/products/tas-102.html","C10H11F3N2O5.0.5C9H11ClN4O2.0.5HCl","hydrochloride","Trifluridine-Tipiracil Hydrochloride Mixture","Cl.OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C(F)(F)F.OCC3OC(CC3O)N4C=C(C(=O)NC4=O)C(F)(F)F.ClC5=C(CN6CCCC6=N)NC(=O)NC5=O",-1.951,8,8,8]
["S8541","FM-381","a10","L6200-22","in 10mM DMSO","JAK","JAK/STAT","FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.",428.49,"2226521-65-7",{"v":20,"d":"20.00"},46.68,"<1","N/A","http://selleckchem.com/products/fm-381.html","C24H24N6O2","free base","N/A","CN(C)C(=O)/C(=C/C1=CC=C(O1)C2=NC3=CN=C4[NH]C=CC4=C3[N]2C5CCCCC5)C#N",4.084,4,1,4]
["S8558","Tofogliflozin(CSG 452)","b10","L6200-22","in 10mM DMSO","SGLT","GPCR & G Protein","Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.",404.45,"1201913-82-7",{"v":84,"d":"84.00"},207.69,{"v":4,"d":"4.00"},9.89,"http://selleckchem.com/products/tofogliflozin-csg-452.html","C22H26O6.H2O","hydrate","N/A","O.CCC1=CC=C(CC2=CC3=C(COC34OC(CO)C(O)C(O)C4O)C=C2)C=C1",{"v":1.92,"d":"1.920"},2,4,4]
["S8560","Seletalisib (UCB-5857)","c10","L6200-22","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).",482.85,"1362850-20-1",{"v":97,"d":"97.00"},200.89,"<1","N/A","http://www.selleckchem.com/products/seletalisib-ucb-5857.html","C23H14ClF3N6O","Free Base","N/A","[O-][N+]1=CC=CC(=C1)C2=NC3=C(Cl)C=CC=C3C=C2C(NC4=C5N=CC=CC5=NC=N4)C(F)(F)F",4.436,4,1,5]
["S8561","HJC0152","d10","L6200-22","in 10mM DMSO","STAT","JAK/STAT","HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.",406.65,"1420290-99-8",{"v":88,"d":"88.00"},{"v":216.4,"d":"216.40"},"<1","N/A","http://selleckchem.com/products/hjc0152.html","C15H13Cl2N3O4.HCl","hydrochloride","N/A","Cl.NCCOC1=C(C=C(Cl)C=C1)C(=O)NC2=C(Cl)C=C(C=C2)[N+]([O-])=O",3.374,2,2,6]
["S8564","Verubecestat (MK-8931)","e10","L6200-22","in 10mM DMSO","BACE","Neuronal Signaling","Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.",409.41,"1286770-55-5",{"v":81,"d":"81.00"},197.85,"<1","N/A","http://selleckchem.com/products/verubecestat.html","C17H17F2N5O3S","free base","N/A","CN1C(=N)NC(C)(C[S]1(=O)=O)C2=CC(=CC=C2F)NC(=O)C3=CC=C(F)C=N3",1.314,4,2,3]
["S8565","Omarigliptin (MK-3102)","f10","L6200-22","in 10mM DMSO","DPP","Proteases","Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).",398.43,"1226781-44-7",{"v":79,"d":"79.00"},198.28,"<1","N/A","http://selleckchem.com/products/omarigliptin-mk-3102.html","C17H20F2N4O3S","free base","N/A","C[S](=O)(=O)[N]1C=C2CN(CC2=N1)C3COC(C(N)C3)C4=C(F)C=CC(=C4)F",1.098,4,1,3]
["S8567","Tucidinostat (Chidamide)","g10","L6200-22","in 10mM DMSO","HDAC","Epigenetics","Tucidinostat (Chidamide, HBI-8000, CS-055) is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.",390.41,"1616493-44-7",{"v":78,"d":"78.00"},199.79,"<1","N/A","http://selleckchem.com/products/tucidinostat-chidamide.html","C22H19FN4O2","free base","HBI-8000, CS-055","NC1=C(NC(=O)C2=CC=C(CNC(=O)\\C=C\\C3=CC=CN=C3)C=C2)C=C(F)C=C1",2.182,3,3,6]
["S8572","Amcasertib (BBI503)","h10","L6200-22","in 10mM DMSO","Stemness kinase","Stem Cells & Wnt","Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.",539.69,"1129403-56-0",{"v":14,"d":"14.00"},25.94,"<1","N/A","http://selleckchem.com/products/amcasertib-bbi503.html","C31H33N5O2S","free base","N/A","CCN(CC)CCNC(=O)C1=C(C)[NH]C(=C1C)\\C=C/2C(=O)NC3=CC=C(C=C23)C4=CSC(=N4)C5=CC=CC=C5",5.119,3,3,9]
["S8576","EAD1","a11","L6200-22","in 10mM DMSO","Autophagy","Autophagy","EAD1 is a potent autophagy inhibitor with an IC50 of 5.8 μM in the BxPC3 cells. It has antiproliferative activities in lung and pancreatic cancer cells.",598.45,"2320427-95-8",{"v":100,"d":"100.00"},{"v":167.1,"d":"167.10"},{"v":100,"d":"100.00"},{"v":167.1,"d":"167.10"},"http://selleckchem.com/products/ead1.html","C26H28Cl2F3N7O2","Trifluoroacetate","N/A","CN(CCNCC1=C[N](CC2=CC=C(Cl)C=C2)N=N1)CCNC3=CC=NC4=CC(=CC=C34)Cl.OC(=O)C(F)(F)F",2.308,4,2,12]
["S8580","COTI-2","b11","L6200-22","in 10mM DMSO","p53","Apoptosis","COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.",366.48,"1039455-84-9",{"v":73,"d":"73.00"},199.19,"<1","N/A","http://selleckchem.com/products/coti-2.html","C19H22N6S","free base","N/A","S=C(N\\N=C/1CCCC2=C1N=CC=C2)N3CCN(CC3)C4=NC=CC=C4",3.825,3,1,4]
["S8581","Serabelisib (TAK-117)","c11","L6200-22","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.",363.37,"1268454-23-4",{"v":16,"d":"16.00"},44.03,"<1","N/A","http://selleckchem.com/products/tak-117-ink-1117-mln-1117.html","C19H17N5O3","free base","INK-1117, MLN-1117","NC1=NC2=C(O1)C=CC(=C2)C3=C[N]4C(=NC=C4C(=O)N5CCOCC5)C=C3",0.939,5,1,2]
["S8588","ACSS2 inhibitor","d11","L6200-22","in 10mM DMSO","ACSS2,RSV","Metabolism","ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).",410.51,"508186-14-9",{"v":30,"d":"30.00"},73.08,"<1","N/A","http://selleckchem.com/products/acss2-inhibitor.html","C20H18N4O2S2","free base","N/A","COCCNC(=O)NC1=CC2=C(C=C1)N=C(C3=CC=CS3)C(=N2)C4=CC=CS4",{"v":4.08,"d":"4.080"},4,2,6]
["S8589","SF2523","e11","L6200-22","in 10mM DMSO","DNA-PK,Epigenetic Reader Domain,mTOR,PI3K","PI3K/Akt/mTOR","SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.",371.41,"1174428-47-7",{"v":29,"d":"29.00"},78.08,"<1","N/A","http://selleckchem.com/products/sf2523.html","C19H17NO5S","free base","N/A","O=C1C=C(OC2=C1SC=C2C3=CC=C4OCCOC4=C3)N5CCOCC5",3.081,5,0,2]
["S8592","Pamiparib (BGB-290)","f11","L6200-22","in 10mM DMSO","PARP","DNA Damage/DNA Repair","Pamiparib (BGB-290) is a potent and selective inhibitor of PARP1 and PARP2 with IC50 values of 0.83 and 0.11 nM, respectively in biochemical assays. It shows high selectivity over other PARP enzymes.",298.31,"1446261-44-4",{"v":59,"d":"59.00"},197.78,"<1","N/A","http://www.selleckchem.com/products/bgb-290.html","C16H15FN4O","Free Base","N/A","CC12CCCN1CC3=NNC(=O)C4=CC(=CC5=C4C3=C2[NH]5)F",2.078,2,2,0]
["S8596","Autophinib","g11","L6200-22","in 10mM DMSO","Autophagy,PI3K","Autophagy","Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.",346.73,"1644443-47-9",{"v":69,"d":"69.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/autophinib.html","C14H11ClN6O3","free base","N/A","CC1=CC(=N[NH]1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+]([O-])=O)Cl",4.118,4,2,5]
["S8597","LYN-1604","h11","L6200-22","in 10mM DMSO","Autophagy,ULK","Autophagy","LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.",657.54,"2088939-99-3",{"v":50,"d":"50.00"},76.04,{"v":100,"d":"100.00"},152.08,"http://selleckchem.com/products/lyn-1604.html","C33H45Cl4N3O2","dihydrochloride","N/A","Cl.Cl.CC(C)CN(CC(C)C)CC(=O)N1CCN(CC1)CC(OCC2=CC=C3C=CC=CC3=C2)C4=CC=C(Cl)C=C4Cl",7.992,2,0,12]
["S8603","NGP 555","a2","L6200-23","in 10mM DMSO","Secretase","Proteases","NGP 555 is a small-molecule modulator of  γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.",406.52,"1304630-27-0",{"v":40,"d":"40.00"},{"v":98.4,"d":"98.40"},"<1","N/A","http://selleckchem.com/products/npg-555.html","C23H23FN4S","free base","N/A","CCC1=C(C)C=C(C)C(=C1)NC2=NC(=CS2)C3=CC=C([N]4C=NC(=C4)C)C(=C3)F",6.396,2,1,5]
["S8605","C188-9","b2","L6200-23","in 10mM DMSO","STAT","JAK/STAT","C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.",471.52,"432001-19-9",{"v":94,"d":"94.00"},199.36,"<1","N/A","http://selleckchem.com/products/c188-9.html","C27H21NO5S","free base","TTI 101","COC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=C(O)C3=CC=CC=C23)C4=C(O)C=CC5=C4C=CC=C5",5.152,3,3,5]
["S8607","JQ-EZ-05 (JQEZ5)","c2","L6200-23","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","JQ-EZ-05 (JQEZ5) is a specific and reversible EZH1/2 inhibitor.",542.68,"1913252-04-6",{"v":24,"d":"24.00"},44.22,"N/A","N/A","http://selleckchem.com/products/jq-ez-05-jqez5.html","C30H38N8O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=NC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.379,5,2,8]
["S8615","Sodium dichloroacetate (DCA)","d2","L6200-23","in 10mM DMSO","Apoptosis related,Dehydrogenase,NKCC,ROS","Metabolism","Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.",150.92,"2156-56-1",{"v":30,"d":"30.00"},198.78,{"v":30,"d":"30.00"},198.78,"http://selleckchem.com/products/sodium-dichloroacetate-dca.html","C2HCl2O2.Na","sodium salt","Dichloroacetic acid, bichloroacetic acid, BCA","[Na]OC(=O)C(Cl)Cl",1.081,2,0,2]
["S8627","OSS_128167","e2","L6200-23","in 10mM DMSO","HBV,Sirtuin","Epigenetics","OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.",366.32,"887686-02-4",{"v":73,"d":"73.00"},199.28,"<1","N/A","http://selleckchem.com/products/oss-128167.html","C19H14N2O6","free base","SIRT6-IN-1","OC(=O)C1=CC(=CC=C1O)NC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=CO3",2.182,4,3,5]
["S8628","3-TYP","f2","L6200-23","in 10mM DMSO","Sirtuin","Cytoskeletal Signaling","3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.",146.15,"120241-79-4",{"v":29,"d":"29.00"},198.43,{"v":5,"d":"5.00"},34.21,"http://selleckchem.com/products/3-typ.html","C7H6N4","free base","3-(1H-1,2,3-triazol-4-yl) pyridine","[NH]1C=C(N=N1)C2=CC=CN=C2",0.602,3,1,1]
["S8632","Chk2 Inhibitor II (BML-277)","g2","L6200-23","in 10mM DMSO","Apoptosis related,Chk","Cell Cycle","Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Chk2 Inhibitor II (BML-277) dose dependently protects human CD4(+) and CD8(+) T-cells from apoptosis due to ionizing radiation.",{"v":363.8,"d":"363.80"},"516480-79-8",{"v":72,"d":"72.00"},197.91,"<1","N/A","http://selleckchem.com/products/chk2-inhibitor-2-bml-277.html","C20H14ClN3O2","free base","N/A","NC(=O)C1=CC=C2[NH]C(=NC2=C1)C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3",4.497,3,2,4]
["S8639","Diphenyleneiodonium chloride (DPI)","h2","L6200-23","in 10mM DMSO","NADPH-oxidase,NOS,ROS,TRP Channel","Immunology & Inflammation","Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. Diphenyleneiodonium chloride (DPI) also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).",314.55,"4673-26-1",{"v":13,"d":"13.00"},41.33,"<1","N/A","http://selleckchem.com/products/diphenyleneiodonium-chloride-dpi.html","C12H8I.Cl","chloride","N/A","[Cl-].[I+]1C2=CC=CC=C2C3=C1C=CC=C3",1.101,0,0,0]
["S8642","GSK'963","a3","L6200-23","in 10mM DMSO","RIP kinase","Apoptosis","GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.",230.31,"2049868-46-2",{"v":46,"d":"46.00"},199.73,"<1","N/A","http://selleckchem.com/products/gsk963.html","C14H18N2O","free base","N/A","CC(C)(C)C(=O)N1N=CCC1C2=CC=CC=C2",2.545,2,0,2]
["S8644","GNF-6231","b3","L6200-23","in 10mM DMSO","PORCN","Stem Cells & Wnt","GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.",448.49,"1243245-18-2",{"v":89,"d":"89.00"},198.44,"<1","N/A","http://selleckchem.com/products/gnf-6231.html","C24H25FN6O2","free base","N/A","CC(=O)N1CCN(CC1)C2=CC=C(NC(=O)CC3=CC(=C(N=C3)C4=CC(=NC=C4)F)C)N=C2",2.135,5,1,5]
["S8645","IWP-O1","c3","L6200-23","in 10mM DMSO","PORCN","Stem Cells & Wnt","IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.",432.48,"2074607-48-8",{"v":86,"d":"86.00"},198.85,"<1","N/A","http://selleckchem.com/products/iwp-O1.html","C26H20N6O","free base","N/A","O=C(C[N]1N=NC(=C1C2=CC=CC=C2)C3=CC=NC=C3)NC4=NC=C(C=C4)C5=CC=CC=C5",4.161,5,1,6]
["S8647","iCRT3","d3","L6200-23","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.",394.53,"901751-47-1",{"v":78,"d":"78.00"},{"v":197.7,"d":"197.70"},"<1","N/A","http://selleckchem.com/products/icrt3.html","C23H26N2O2S","free base","N/A","CCC1=CC=C(C=C1)C2=NC(=C(C)O2)CSCC(=O)NCCC3=CC=CC=C3",4.468,3,1,9]
["S8648","ACY-738","e3","L6200-23","in 10mM DMSO","HDAC","Epigenetics","ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.",270.29,"1375465-91-0",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/acy-738.html","C14H14N4O2","free base","N/A","ONC(=O)C1=CN=C(NC2(CC2)C3=CC=CC=C3)N=C1",1.325,3,2,4]
["S8654","ex229 (compound 991)","f3","L6200-23","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.",431.87,"1219739-36-2",{"v":12,"d":"12.00"},27.79,"<1","N/A","http://www.selleckchem.com/products/ex229-compound-991.html","C24H18ClN3O3","Free Base","N/A","C[N]1C=CC2=C1C=CC(=C2)C3=C(Cl)C=C4[NH]C(=NC4=C3)OC5=CC(=C(C)C=C5)C(O)=O",6.245,3,1,4]
["S8658","kira6","g3","L6200-23","in 10mM DMSO","IRE1","ER stress & UPR","kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.",518.53,"1589527-65-0",{"v":60,"d":"60.00"},115.71,"<1","N/A","http://selleckchem.com/products/kira6.html","C28H25F3N6O","free base/salt","N/A","CC(C)(C)C1=NC(=C2[N]1C=CN=C2N)C3=CC=C(NC(=O)NC4=CC=CC(=C4)C(F)(F)F)C5=C3C=CC=C5",5.531,3,3,5]
["S8660","GI254023X","h3","L6200-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.GI254023X can inhibit MMP9.",{"v":391.5,"d":"391.50"},"260264-93-5",{"v":78,"d":"78.00"},199.23,"<1","N/A","http://selleckchem.com/products/gi254023x.html","C21H33N3O4","free base","GI 4023, SRI028594","CNC(=O)C(NC(=O)C(CCCC1=CC=CC=C1)C(C)N(O)C=O)C(C)(C)C",2.517,3,2,10]
["S8661","CA3 (CIL56)","a4","L6200-23","in 10mM DMSO","Ferroptosis,ROS,TEAD,YAP","Hippo","CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).",489.61,"300802-28-2",{"v":97,"d":"97.00"},198.12,"<1","N/A","http://selleckchem.com/products/ca3.html","C23H27N3O5S2","free base","N/A","O/N=C1/C2=CC(=CC=C2C3=C1C=C(C=C3)[S](=O)(=O)N4CCCCC4)[S](=O)(=O)N5CCCCC5",3.058,5,0,4]
["S8662","PTC-028","b4","L6200-23","in 10mM DMSO","BMI-1","Cell Cycle","PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification.",405.32,"1782970-28-8",{"v":81,"d":"81.00"},199.84,"<1","N/A","http://selleckchem.com/products/ptc-028.html","C19H12F5N5","free base","N/A","CC1=NC2=C(C=C(F)C(=C2)F)[N]1C3=CN=CC(=N3)NC4=CC=C(C=C4)C(F)(F)F",5.069,3,1,4]
["S8664","Pemrametostat (GSK3326595)","c4","L6200-23","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.",452.55,"1616392-22-3",{"v":90,"d":"90.00"},198.87,"<1","N/A","http://selleckchem.com/products/gsk3326595-epz015938.html","C24H32N6O3","free base","EPZ015938","CC(=O)N1CCC(CC1)NC2=CC(=NC=N2)C(=O)NCC(O)CN3CCC4=C(C3)C=CC=C4",0.692,4,3,7]
["S8666","Elimusertib (BAY-1895344) hydrochloride","d4","L6200-23","in 10mM DMSO","ATM/ATR","DNA Damage/DNA Repair","Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.",411.89,"1876467-74-1(free base)",{"v":82,"d":"82.00"},199.08,{"v":82,"d":"82.00"},199.08,"https://www.selleckchem.com/products/bay-1895344-hcl.html","C20H22ClN7O","hydrochloride","BAY-1895344 HCl","Cl.CC1COCCN1C2=CC(=C3C=CN=C(C4=CC=N[NH]4)C3=N2)C5=CC=N[N]5C",3.156,5,1,3]
["S8672","Tenalisib (RP6530)","e4","L6200-23","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.",415.42,"1639417-53-0",{"v":75,"d":"75.00"},180.54,"<1","N/A","http://selleckchem.com/products/tenalisib-rp6530.html","C23H18FN5O2","free base","N/A","CCC(NC1=C2N=C[NH]C2=NC=N1)C3=C(C(=O)C4=CC=CC=C4O3)C5=CC=CC(=C5)F",{"v":4.07,"d":"4.070"},5,2,5]
["S8680","AZD1390","f4","L6200-23","in 10mM DMSO","ATM/ATR","PI3K/Akt/mTOR","AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.",477.57,"2089288-03-7",{"v":14,"d":"14.00"},29.32,"<1","N/A","http://selleckchem.com/products/azd1390.html","C27H32FN5O2","free base","N/A","CC(C)N1C(=O)N(C)C2=C1C3=CC(=C(F)C=C3N=C2)C4=CC=C(OCCCN5CCCCC5)N=C4",4.231,4,0,7]
["S8684","Selective JAK3 inhibitor 1","g4","L6200-23","in 10mM DMSO","JAK","JAK/STAT","Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.",350.37,"1443235-95-7",{"v":70,"d":"70.00"},199.79,"<1","N/A","http://www.selleck.cn/products/selective-jak3-inhibitor-1.html","C19H18N4O3","Free Base","N/A","CCOC(=O)C1=C[NH]C2=C1C(=NC=N2)C3=CC(=CC=C3)NC(=O)C(C)=C",2.959,5,2,6]
["S8685","AS1517499","h4","L6200-23","in 10mM DMSO","STAT","JAK/STAT","AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.",397.86,"919486-40-1",{"v":79,"d":"79.00"},198.56,"<1","N/A","http://selleckchem.com/products/as1517499.html","C20H20ClN5O2","free base","N/A","NC(=O)C1=CN=C(NCCC2=CC=C(O)C(=C2)Cl)N=C1NCC3=CC=CC=C3",3.641,3,4,8]
["S8693","Selective PI3Kδ Inhibitor 1 (compound 7n)","a5","L6200-23","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].",429.45,"2088525-31-7",{"v":43,"d":"43.00"},100.13,"<1","N/A","http://www.selleck.cn/products/selective-pi3k-inhibitor-1.html","C23H20FN7O","Free Base","N/A","C[N]1N=C(N=C1C2(CC2)C3=CC=CC=C3)C4=CN=C(N)C(=N4)C5=CC(=C(C=C5)C(N)=O)F",2.957,5,2,5]
["S8696","2-D08","b5","L6200-23","in 10mM DMSO","SUMO","Ubiquitin","2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation.",270.24,"144707-18-6",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/2-d08.html","C15H10O5","free base","2',3',4'-trihydroxy flavone","OC1=CC=C(C(=C1O)O)C2=CC(=O)C3=CC=CC=C3O2",{"v":2.41,"d":"2.410"},2,3,1]
["S8699","SNS-314 Mesylate","c5","L6200-23","in 10mM DMSO","Aurora Kinase","Cell Cycle","SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.",527.04,"1146618-41-8",{"v":100,"d":"100.00"},189.74,"<1","N/A","http://selleckchem.com/products/sns-314.html","C18H15ClN6OS2.CH4O3S","Mesylate","N/A","ClC1=CC=CC(=C1)NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2",3.953,4,3,6]
["S8701","MK-8353 (SCH900353)","d5","L6200-23","in 10mM DMSO","ERK","MAPK","MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).",691.84,"1184173-73-6",{"v":50,"d":"50.00"},72.27,"<1","N/A","http://www.selleck.cn/products/mk-8353-sch900353.html","C37H41N9O3S","Free Base","N/A","CSC1(CCN(CC(=O)N2CCC(=CC2)C3=CC=C(C=C3)C4=N[N](C)C=N4)C1)C(=O)NC5=CC=C6[NH]N=C(C7=CC=C(OC(C)C)N=C7)C6=C5",4.176,7,2,10]
["S8704","iCRT14","e5","L6200-23","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","iCRT14 is a β-catenin/Tcf inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay.",375.44,"677331-12-3",{"v":37,"d":"37.00"},98.55,"<1","N/A","http://www.selleck.cn/products/icrt14.html","C21H17N3O2S","free base","N/A","CC1=CC(=C(C)[N]1C2=CN=CC=C2)\\C=C3/SC(=O)N(C4=CC=CC=C4)C3=O",3.741,3,0,3]
["S8706","UM-164","f5","L6200-23","in 10mM DMSO","p38 MAPK,Src","Protein Tyrosine Kinase","UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.",640.68,"903564-48-7",{"v":100,"d":"100.00"},156.08,"<1","N/A","http://selleckchem.com/products/um-164.html","C30H31F3N8O3S","free base","N/A","CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=CC(=CC=C3C)NC(=O)C4=CC(=CC=C4)C(F)(F)F)N5CCN(CCO)CC5",4.501,5,4,10]
["S8714","INCB057643","g5","L6200-23","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones.",415.46,"1820889-23-3",{"v":83,"d":"83.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/incb057643.html","C20H21N3O5S","Free Base","N/A","CN1C=C(C2=C([NH]C=C2)C1=O)C3=CC(=CC4=C3OC(C)(C)C(=O)N4C)[S](C)(=O)=O",1.114,5,1,2]
["S8723","ABBV-744","h5","L6200-23","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.",491.55,"2138861-99-9",{"v":98,"d":"98.00"},199.37,"<1","N/A","http://www.selleckchem.com/products/abbv-744.html","C28H30FN3O4","Free Base","N/A","CCNC(=O)C1=CC2=C([NH]1)C(=O)N(C)C=C2C3=C(OC4=C(C)C=C(F)C=C4C)C=CC(=C3)C(C)(C)O",{"v":4.36,"d":"4.360"},3,2,6]
["S8727","Atuveciclib (BAY-1143572)","a6","L6200-23","in 10mM DMSO","CDK","Cell Cycle","Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.",387.43,"1414943-88-6",{"v":77,"d":"77.00"},198.75,"<1","N/A","http://www.selleckchem.com/products/atuveciclib-bay-1143572.html","C18H18FN5O2S","Free Base","N/A","COC1=CC(=CC=C1C2=NC(=NC=N2)NC3=CC(=CC=C3)C[S](C)(=N)=O)F",3.699,5,1,6]
["S8728","PK11000","b6","L6200-23","in 10mM DMSO","p53","Apoptosis","PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.",236.63,"38275-34-2",{"v":47,"d":"47.00"},198.62,{"v":47,"d":"47.00"},198.62,"https://www.selleckchem.com/products/pk11000.html","C6H5ClN2O4S","free base","N/A","C[S](=O)(=O)C1=NC=C(Cl)C(=N1)C(O)=O",{"v":0.82,"d":"0.820"},5,0,2]
["S8738","Bimiralisib (PQR309)","c6","L6200-23","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.",411.38,"1225037-39-7",{"v":6,"d":"6.00"},14.59,"<1","N/A","http://www.selleckchem.com/products/pqr309-bimiralisib.html","C17H20F3N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C(=C1)C(F)(F)F",1.891,6,1,4]
["S8739","PLX51107","d6","L6200-23","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range).",438.48,"1627929-55-8",{"v":88,"d":"88.00"},200.69,"<1","N/A","http://www.selleck.cn/products/plx51107.html","C26H22N4O3","Free Base","N/A","CC([N]1C=C(C2=CC=C(C=C2)C(O)=O)C3=NC=C(C=C13)C4=C(C)ON=C4C)C5=CC=CC=N5",4.288,5,0,5]
["S8743","SKLB-23bb","e6","L6200-23","in 10mM DMSO","HDAC","Epigenetics","SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.",396.44,"1815580-06-3",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://www.selleck.cn/products/sklb-23bb.html","C21H24N4O4","free base","N/A","COC1=C(OCCCC(=O)NO)C=C(C=C1)N(C)C2=NC(=NC3=CC=CC=C23)C",3.042,5,1,8]
["S8744","PHY34","f6","L6200-23","in 10mM DMSO","Autophagy","Autophagy","PHY34 is a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo.",582.55,"2130033-55-3",{"v":100,"d":"100.00"},171.66,"<1","N/A","http://www.selleckchem.com/products/phy34.html","C30H30O12","Free Base","N/A","COC1=CC2=C(C=C1OC)C(=C3C(=O)OCC3=C2OC4OC(CO)C5OC(C)(C)OC5C4O)C6=CC=C7OCOC7=C6",2.164,10,2,6]
["S8749","MBQ-167","g6","L6200-23","in 10mM DMSO","Rho","Cell Cycle","MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.",338.41,"2097938-73-1",{"v":68,"d":"68.00"},200.94,"<1","N/A","http://www.selleckchem.com/products/mbq-167.html","C22H18N4","Free Base","N/A","CC[N]1C2=C(C=CC=C2)C3=CC(=CC=C13)[N]4N=NC=C4C5=CC=CC=C5",5.446,2,0,3]
["S8752","leniolisib (CDZ 173)","h6","L6200-23","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Leniolisib (CDZ 173) is a potent PI3Kδ selective inhibitor with biochemical IC50 values of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively.",450.46,"1354690-24-6",{"v":90,"d":"90.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://www.selleckchem.com/products/leniolisib-cdz-173.html","C21H25F3N6O2","Free Base","N/A","CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(OC)N=C4)C(F)(F)F",{"v":2.65,"d":"2.650"},5,1,6]
["S8753","INCB054329","a7","L6200-23","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","INCB054329 (INCB-054329, INCB-54329) is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM for BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2, respectively.",348.36,"1628607-64-6",{"v":70,"d":"70.00"},200.94,"˂1","N/A","http://www.selleck.cn/products/incb054329.html","C19H16N4O3","Free Base","INCB-054329, INCB-54329","CC1=C(C(=NO1)C)C2=CC=C3NC(=O)N4C(COC2=C34)C5=NC=CC=C5",1.884,5,1,2]
["S8760","Iberdomide (CC220)","b7","L6200-23","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,Immunology & Inflammation related","Immunology & Inflammation","Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.",{"v":449.5,"d":"449.50"},"1323403-33-3",{"v":90,"d":"90.00"},200.22,"<1","N/A","http://www.selleck.cn/products/iberdomide.html","C25H27N3O5","free base","N/A","O=C1CCC(N2CC3=C(OCC4=CC=C(CN5CCOCC5)C=C4)C=CC=C3C2=O)C(=O)N1",{"v":1.56,"d":"1.560"},5,1,6]
["S8761","Adavivint (SM04690)","c7","L6200-23","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.",505.55,"1467093-03-3",{"v":30,"d":"30.00"},59.34,"<1","N/A","http://www.selleckchem.com/products/adavivint.html","C29H24FN7O","Free Base","Lorecivivint","CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C([NH]N=C3C4=NC5=C([NH]4)C(=CN=C5)C6=CC=CC(=C6)F)C=C2",4.779,5,3,6]
["S8762","dBET6","d7","L6200-23","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Myc,PROTAC","Epigenetics","dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis.",841.37,"1950634-92-0",{"v":100,"d":"100.00"},118.85,"<1","N/A","http://www.selleck.cn/products/dbet6.html","C42H45ClN8O7S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NCCCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C6CCC(=O)NC6=O)C5=O)N=C2C7=CC=C(Cl)C=C7)C",{"v":4.8,"d":"4.800"},10,3,16]
["S8763","ZL0420","e7","L6200-23","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","ZL0420 is a potent and selective BRD4 inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 respectively and good selectivity over that of the related BRD2 homolog.",296.32,"2229039-45-4",{"v":59,"d":"59.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/zl0420.html","C16H16N4O2","Free Base","N/A","CC1=CC(=C(N)C=C1O)N=NC2=CC3=C(NC(=O)CC3)C=C2",3.142,3,3,2]
["S8764","IITZ-01","f7","L6200-23","in 10mM DMSO","Autophagy","Autophagy","IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.",482.51,"1807988-47-1",{"v":100,"d":"100.00"},207.25,"<1","N/A","http://www.selleckchem.com/products/iitz-01.html","C26H23FN8O","Free Base","N/A","FC1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)NC4=CC=C(C=C4)C5=NC6=C([NH]5)C=CC=C6)C=C1",6.104,5,3,6]
["S8765","Abrocitinib (PF-04965842)","g7","L6200-23","in 10mM DMSO","JAK","JAK/STAT","Abrocitinib (PF-04965842) is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.",323.41,"1622902-68-4",{"v":65,"d":"65.00"},200.98,"<1","N/A","http://www.selleck.cn/products/pf-04965842.html","C14H21N5O2S","free base","N/A","CCC[S](=O)(=O)NC1CC(C1)N(C)C2=C3C=C[NH]C3=NC=N2",1.101,4,2,6]
["S8769","Tinostamustine(EDO-S101)","h7","L6200-23","in 10mM DMSO","HDAC","Epigenetics","Tinostamustine(EDO-S101) is a first-in-class alkylating deacetylase inhibitor with IC50 values of 9 nM, 9 nM, 25 nM and 107 nM for HDAC1, HDAC2, HDAC3 and HDAC8 (Class 1 HDACs) respectively and 6 nM, 72 nM for HDAC6 and HDAC10 (Class II HDACs).",415.36,"1236199-60-2",{"v":14,"d":"14.00"},33.71,"<1","N/A","http://www.selleck.cn/products/tinostamustine.html","C19H28Cl2N4O2","Free Base","N/A","C[N]1C(=NC2=CC(=CC=C12)N(CCCl)CCCl)CCCCCCC(=O)NO",{"v":4.36,"d":"4.360"},2,1,12]
["S8770","Lanifibranor (IVA-337)","a8","L6200-23","in 10mM DMSO","PPAR","Metabolism","Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively.",434.92,"927961-18-0",{"v":87,"d":"87.00"},200.04,"<1","N/A","http://www.selleckchem.com/products/lanifibranor-iva-337.html","C19H15ClN2O4S2","Free Base","N/A","OC(=O)CCCC1=CC2=CC(=CC=C2[N]1[S](=O)(=O)C3=CC4=C(C=C3)N=CS4)Cl",4.676,4,0,6]
["S8771","IDF-11774","b8","L6200-23","in 10mM DMSO","HIF","Angiogenesis","IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.",368.51,"1429054-28-3",{"v":15,"d":"15.00"},{"v":40.7,"d":"40.70"},"<1","N/A","http://www.selleckchem.com/products/idf-11774.html","C23H32N2O2","Free Base","N/A","CN1CCN(CC1)C(=O)COC2=CC=C(C=C2)[C]34C[CH]5[CH2]C([CH2][CH](C5)C3)C4",3.446,2,0,4]
["S8772","LY 3200882","c8","L6200-23","in 10mM DMSO","TGF-beta/Smad","TGF-beta/Smad","LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.",435.52,"1898283-02-7",{"v":87,"d":"87.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/ly3200882.html","C24H29N5O3","Free Base","N/A","CC(C)(O)C1=NC=CC(=C1)NC2=NC=CC(=C2)OC3=C[N](N=C3C4CCOCC4)C5CC5",3.363,5,1,7]
["S8773","TH34","d8","L6200-23","in 10mM DMSO","HDAC","Epigenetics","TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3.  In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM).",{"v":256.3,"d":"256.30"},"2196203-96-8",{"v":51,"d":"51.00"},198.99,"<1","N/A","http://www.selleckchem.com/products/th34.html","C15H16N2O2","Free Base","N/A","CC1=CC=C(C=C1NCC2=CC=CC=C2)C(=O)NO",2.723,1,2,4]
["S8776","WM-1119","e8","L6200-23","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.",389.38,"2055397-28-7",{"v":78,"d":"78.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/wm-1119.html","C18H13F2N3O3S","Free Base","N/A","FC1=CC(=CC(=C1)C(=O)NN[S](=O)(=O)C2=CC=CC=C2F)C3=NC=CC=C3",2.781,4,2,5]
["S8778","UPGL00004","f8","L6200-23","in 10mM DMSO","Glutaminase","Proteases","UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.",534.66,"1890169-95-5",{"v":25,"d":"25.00"},46.76,"<1","N/A","http://www.selleck.cn/products/upgl00004.html","C25H26N8O2S2","free base","N/A","O=C(CC1=CC=CC=C1)NC2=NN=C(NC3CCN(CC3)C4=NN=C(NC(=O)CC5=CC=CC=C5)S4)S2",3.091,6,3,9]
["S8789","SSE15206","g8","L6200-23","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.",371.45,"1370046-40-4",{"v":74,"d":"74.00"},199.22,"<1","N/A","http://www.selleckchem.com/products/sse15206.html","C19H21N3O3S","Free Base","N/A","COC1=C(OC)C(=CC(=C1)C2CC(=NN2C(N)=S)C3=CC=CC=C3)OC",3.483,4,1,6]
["S8790","ML385","h8","L6200-23","in 10mM DMSO","Ferroptosis,Nrf2","Immunology & Inflammation","ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.",511.59,"846557-71-9",{"v":74,"d":"74.00"},144.65,"<1","N/A","http://www.selleckchem.com/products/ml385.html","C29H25N3O4S","Free Base","N/A","CC1=C(N=C(NC(=O)CC2=CC3=C(OCO3)C=C2)S1)C4=CC=C5N(CCC5=C4)C(=O)C6=C(C)C=CC=C6",5.058,5,1,5]
["S8801","CC-90003","a9","L6200-23","in 10mM DMSO","ERK","MAPK","CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay.",458.44,"1621999-82-3",{"v":92,"d":"92.00"},200.68,"<1","N/A","http://www.selleckchem.com/products/cc-90003.html","C22H21F3N6O2","Free Base","N/A","COC1=CC(=C(C)C=N1)NC2=NC(=C(C=N2)C(F)(F)F)NC3=C(NC(=O)C=C)C=C(C)C=C3",5.316,5,3,8]
["S8803","MK-3903","b9","L6200-23","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.",{"v":454.9,"d":"454.90"},"1219737-12-8",{"v":91,"d":"91.00"},200.04,"<1","N/A","http://www.selleckchem.com/products/mk-3903.html","C27H19ClN2O3","Free Base","N/A","CC1=CC=C(OC2=NC3=CC(=C(C=C3[NH]2)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C=C1C(O)=O",7.264,3,1,5]
["S8804","Brepocitinib (PF-06700841)","c9","L6200-23","in 10mM DMSO","JAK","JAK/STAT","Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.",{"v":389.4,"d":"389.40"},"1883299-62-4",{"v":78,"d":"78.00"},200.31,"<1","N/A","http://www.selleck.cn/products/pf-06700841.html","C18H21F2N7O","Free Base","PF-841","C[N]1C=C(NC2=NC=CC(=N2)N3CC4CCC(C3)N4C(=O)C5CC5(F)F)C=N1",1.608,4,1,4]
["S8807","PFK158","d9","L6200-23","in 10mM DMSO","Autophagy,PFKFB","Cell Cycle","PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.",328.29,"1462249-75-7",{"v":14,"d":"14.00"},42.65,"<1","N/A","http://www.selleck.cn/products/pfk158.html","C18H11F3N2O","free base","N/A","FC(F)(F)C1=CC=C2C=CC(=NC2=C1)\\C=C\\C(=O)C3=CC=NC=C3",4.108,3,0,4]
["S8808","DC661","e9","L6200-23","in 10mM DMSO","Apoptosis related,Autophagy","Autophagy","DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). DC661 induces apoptosis.",552.58,"1872387-43-3",{"v":62,"d":"62.00"},{"v":112.2,"d":"112.20"},"<1","N/A","http://www.selleck.cn/products/dc661.html","C31H39Cl2N5","free base","N/A","CN(CCCCCCNC1=CC=NC2=CC(=CC=C12)Cl)CCCCCCNC3=CC=NC4=C3C=CC(=C4)Cl",8.045,2,2,16]
["S8810","SPHINX31","f9","L6200-23","in 10mM DMSO","Serine/threonin kinase","Protein Tyrosine Kinase","SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold).",507.51,"1818389-84-2",{"v":25,"d":"25.00"},49.26,"<1","N/A","http://www.selleck.cn/products/sphinx31.html","C27H24F3N5O2","free base","N/A","FC(F)(F)C1=CC(=C(C=C1)N2CCN(CC2)CC3=CC=CC=N3)NC(=O)C4=CC=C(O4)C5=CC=NC=C5",4.378,4,1,7]
["S8813","LIT-927","g9","L6200-23","in 10mM DMSO","CXCR","Immunology & Inflammation","LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.",328.75,"2172879-52-4",{"v":66,"d":"66.00"},200.76,"<1","N/A","http://www.selleckchem.com/products/lit-927.html","C17H13ClN2O3","Free Base","N/A","COC1=CC(=CC=C1O)C2=CC(=NC(=O)N2)C3=CC=C(Cl)C=C3",3.599,3,2,3]
["S8818","V-9302","h9","L6200-23","in 10mM DMSO","Amino acid transporter","Transmembrane Transporters","V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2, SLC38A2) and the large neutral AA transporter 1 (LAT1, SLC7A5) as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.",538.68,"1855871-76-9",{"v":100,"d":"100.00"},185.64,{"v":100,"d":"100.00"},185.64,"http://www.selleck.cn/products/v-9302.html","C34H38N2O4","free base","N/A","CC1=CC(=CC=C1)COC2=C(CN(CCC(N)C(O)=O)CC3=CC=CC=C3OCC4=CC=CC(=C4)C)C=CC=C2",3.409,3,1,14]
["S8846","compound 3i (666-15)","a10","L6200-23","in 10mM DMSO","Epigenetic Reader Domain","Epigenetics","Compound 3i (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription (IC50 = 0.081 ± 0.04 μM) and also potently inhibits cancer cell growth without harming normal cells.",620.52,"1433286-70-4",{"v":100,"d":"100.00"},161.16,"<1","N/A","http://www.selleck.cn/products/compound-3i.html","C33H31Cl2N3O5","Free Base","N/A","Cl.NCCCOC1=C(C=C2C=CC=CC2=C1)C(=O)NCCOC3=CC4=CC=CC=C4C=C3C(=O)NC5=CC=C(Cl)C=C5O",5.293,4,4,11]
["S8872","GSK8612","b10","L6200-23","in 10mM DMSO","TBK1","Immunology & Inflammation","GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified.",520.33,"2361659-62-1",{"v":100,"d":"100.00"},192.19,"<1","N/A","http://www.selleck.cn/products/gsk8612.html","C17H17BrF3N7O2S","free base","N/A","CC1=N[N](CC(F)(F)F)C=C1NC2=NC=C(Br)C(=N2)NCC3=CC=C(C=C3)[S](N)(=O)=O",3.447,5,3,8]
["S9002","L-Fucose","c10","L6200-23","in 10mM DMSO","Others","Others","Fucose (6-Deoxy-L-Galactose, L-fucopyranose) is found on N-linked glycans on the mammalian, insect and plant cell surface. L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements.",164.16,"2438-80-4",{"v":33,"d":"33.00"},201.03,"N/A","N/A","https://www.selleckchem.com/products/l-fucose.html","C6H12O5","free base","6-Deoxy-L-Galactose, L-fucopyranose","CC(O)C(O)C(O)C(O)C=O",-1.903,1,4,4]
["S9018","Luteoloside","d10","L6200-23","in 10mM DMSO","3C-Like Protease,ADC Cytotoxin,Enterovirus","Microbiology","Luteoloside (Cynaroside, Luteolin 7-β-D-Glucopyranoside) is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. It is an inhibitor of 3C Protease of Enterovirus 71 with an IC50 value of 0.36 mM.",448.38,"5373-11-5",{"v":10,"d":"10.00"},{"v":22.3,"d":"22.30"},"N/A","N/A","https://www.selleckchem.com/products/luteoloside.html","C21H20O11","free base","Cynaroside, Luteolin 7-β-D-Glucopyranoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",0.238,4,7,4]
["S9020","Dihydrotanshinone I","e10","L6200-23","in 10mM DMSO","Others","Others","Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA.",{"v":278.3,"d":"278.30"},"87205-99-0",{"v":10,"d":"10.00"},35.93,"N/A","N/A","https://www.selleckchem.com/products/dihydrotanshinone-i.html","C18H14O3","free base","15,16-dihydrotanshinone I","CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3C=CC=C4C",3.184,3,0,0]
["S9021","(20R)Ginsenoside Rg3","f10","L6200-23","in 10mM DMSO","ROS","Immunology & Inflammation","(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.",785.01,"38243-03-7",{"v":10,"d":"10.00"},12.74,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rg3.html","C42H72O13","free base","OG15964","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["S9022","20S-Ginsenoside Rg3","g10","L6200-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.",785.01,"14197-60-5",{"v":10,"d":"10.00"},12.74,"N/A","N/A","https://www.selleckchem.com/products/20s-ginsenoside-rg3.html","C42H72O13","free base","3b-[2-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]-dammar-24-ene-12b, 20 diol","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(C)(C)C4CCC23C",2.295,4,8,10]
["S9026","Hastatoside","h10","L6200-23","in 10mM DMSO","Others","Others","Hastatoside is a characteristic constituent of  V. officinalis and exhibit various biological activities including sleep-promoting, antioxidant and hepatoprotective activity.",404.37,"50816-24-5",{"v":10,"d":"10.00"},24.73,"N/A","N/A","https://www.selleckchem.com/products/hastatoside.html","C17H24O11","free base","N/A","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C3C(C)CC(=O)C13O",-2.441,6,4,5]
["S9031","Gambogenic acid","a11","L6200-23","in 10mM DMSO","EZH1/2,FGFR","Angiogenesis","Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.",630.77,"173932-75-7",{"v":10,"d":"10.00"},15.85,"N/A","N/A","https://www.selleckchem.com/products/gambogenic-acid.html","C38H46O8","free base","N/A","CC(C)=CCC/C(C)=C/CC1=C(O)C2=C(OC34C5CC(C=C3C2=O)C(=O)C4(C\\C=C(\\C)C(O)=O)OC5(C)C)C(=C1O)CC=C(C)C",7.717,5,2,10]
["S9032","Sanguinarine","b11","L6200-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.",332.33,"2447-54-3",{"v":44,"d":"44.00"},{"v":132.4,"d":"132.40"},"N/A","N/A","https://www.selleckchem.com/products/sanguinarine.html","C20H14NO4","free base","Pseudochelerythrine, Sanguinarin, Sanguinarium","C[N+]1=CC2=C3OCOC3=CC=C2C4=C1C5=CC6=C(OCO6)C=C5C=C4",3.987,4,0,0]
["S9033","Incensole acetate","c11","L6200-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.",348.52,"34701-53-6","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/incensole-acetate.html","C22H36O3","free base","FI145245","CC(C)C12CCC(C)(O1)C(CC/C(=C/CC\\C(=C\\C2)C)C)OC(C)=O",{"v":0,"d":"0.000"},0,0,0]
["S9034","Isochlorogenic acid C","d11","L6200-23","in 10mM DMSO","ROS","Immunology & Inflammation","Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.",516.45,"57378-72-0",{"v":10,"d":"10.00"},19.36,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-c.html","C25H24O12","free base","3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,5,9]
["S9036","(20R)Ginsenoside Rh2","e11","L6200-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","(20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.,",622.87,"112246-15-8",{"v":100,"d":"100.00"},160.55,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rh2.html","C36H62O8","free base","FG73845","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(OC5OC(CO)C(O)C(O)C5O)C(C)(C)C4CCC23C",4.042,2,5,7]
["S9038","Calycosin","f11","L6200-23","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Calycosin (3'-Hydroxyformononetin), an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects.",284.26,"20575-57-9",{"v":57,"d":"57.00"},200.52,"N/A","N/A","https://www.selleckchem.com/products/calycosin.html","C16H12O5","free base","3'-Hydroxyformononetin","COC1=C(O)C=C(C=C1)C2=COC3=C(C=CC(=C3)O)C2=O",2.366,3,2,2]
["S9039","Albiflorin","g11","L6200-23","in 10mM DMSO","5-HT Receptor","Neuronal Signaling","Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.",480.46,"39011-90-0",{"v":10,"d":"10.00"},20.81,"N/A","N/A","https://www.selleckchem.com/products/albiflorin.html","C23H28O11","free base","OA10410","CC12CC(O)C3CC1(OC4OC(CO)C(O)C(O)C4O)C3(COC(=O)C5=CC=CC=C5)C(=O)O2",-1.333,6,5,7]
["S9040","Maslinic acid","h11","L6200-23","in 10mM DMSO","NF-κB","NF-κB","Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.",{"v":472.7,"d":"472.70"},"4373-41-5",{"v":10,"d":"10.00"},21.16,"N/A","N/A","https://www.selleckchem.com/products/maslinic-acid.html","C30H48O4","free base","Crategolic Acid, 2α-Hydroxyoleanoic Acid","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1)C(O)=O",{"v":5.48,"d":"5.480"},1,2,1]
["S9041","Corosolic acid","a2","L6200-24","in 10mM DMSO","NF-κB","NF-κB","Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells.",{"v":472.7,"d":"472.70"},"4547-24-4",{"v":95,"d":"95.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/corosolic-acid.html","C30H48O4","free base","Glucosol, Colosic acid, 2α-Hydroxyursolic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC34C)C2C1C)C(O)=O",5.525,1,2,1]
["S9042","Wedelolactone","b2","L6200-24","in 10mM DMSO","Caspase,IκB/IKK","NF-κB","Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.",314.25,"524-12-9",{"v":63,"d":"63.00"},200.48,"N/A","N/A","https://www.selleckchem.com/products/wedelolactone.html","C16H10O7","free base","FW73945","COC1=CC2=C(C(=C1)O)C3=C(C(=O)O2)C4=C(O3)C=C(O)C(=C4)O",2.803,4,3,1]
["S9043","6-Shogaol","c2","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.,",276.37,"555-66-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/6-shogaol.html","C17H24O3","free base","FS42771","CCCCC/C=C/C(=O)CCC1=CC=C(O)C(=C1)OC",4.717,2,1,9]
["S9046","Berberine","d2","L6200-24","in 10mM DMSO","Bacterial","Microbiology","Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.",336.36,"2086-83-1",{"v":45,"d":"45.00"},133.78,"N/A","N/A","https://www.selleckchem.com/products/berberine.html","C20H18NO4","free base","Umbellatine","COC1=C(OC)C2=C(C=C1)C=C3C4=C(CC[N+]3=C2)C=C5OCOC5=C4",3.962,4,0,2]
["S9047","Leonurine Hydrochloride","e2","L6200-24","in 10mM DMSO","Others","Others","Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.",347.79,"24735-18-0",{"v":70,"d":"70.00"},201.27,"N/A","N/A","https://www.selleckchem.com/products/leonurine-hydrochloride.html","C14H22ClN3O5","free base","SCM-198 HCl","Cl.COC1=C(O)C(=CC(=C1)C(=O)OCCCCNC(N)=N)OC",1.472,4,3,10]
["S9048","(+)-Gallocatechin","f2","L6200-24","in 10mM DMSO","Cannabinoid Receptor","GPCR & G Protein","(+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant.",306.27,"970-73-0",{"v":10,"d":"10.00"},32.65,"N/A","N/A","https://www.selleckchem.com/products/gallocatechin.html","C15H14O7","free base","(2S, 3R)-3, 4-Dihydro-2-(3, 4, 5-trihydroxyphenyl)-2H-1-benzopyran-3, 5, 7-triol; (2S-trans)-3, 4-Dihydro-2-(3, 4, 5-trihydroxyphenyl)-2H-1-benzopyran-3, 5, 7-triol; (-)-Gallocatechol; Gallocatechin","OC1CC2=C(OC1C3=CC(=C(O)C(=C3)O)O)C=C(O)C=C2O",1.779,1,6,1]
["S9055","Salvianolic acid A","g2","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.",494.45,"96574-01-5",{"v":10,"d":"10.00"},20.22,"N/A","N/A","https://www.selleckchem.com/products/salvianolic-acid-a.html","C26H22O10","free base","Dan Phenolic Acid A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)\\C=C\\C2=C(/C=C/C3=CC(=C(O)C=C3)O)C(=C(O)C=C2)O",4.209,3,6,9]
["S9057","Sinigrin","h2","L6200-24","in 10mM DMSO","Fungal,Immunology & Inflammation related","Microbiology","Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.",397.46,"3952-98-5",{"v":10,"d":"10.00"},25.16,"N/A","N/A","https://www.selleckchem.com/products/sinigrin.html","C10H16KNO9S2","free base","Allylglucosinolate, 2-Propenylglucosinolate","[K+].OCC1OC(S\\C(CC=C)=N\\O[S]([O-])(=O)=O)C(O)C(O)C1O",-3.447,3,4,7]
["S9061","Hydroxy safflor yellow A","a3","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.",612.53,"78281-02-4",{"v":10,"d":"10.00"},16.33,"N/A","N/A","https://www.selleckchem.com/products/hydroxy-safflor-yellow-a.html","C27H32O16","free base","2, 4-Di-b-D-glucopyranosyl-3, 4, 5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)-2, 5-cyclohexadien-1-one; Safflomin A","OCC1OC(C(O)C(O)C1O)C2=C(O)C(O)(C3OC(CO)C(O)C(O)C3O)C(=C(C(=O)\\C=C\\C4=CC=C(O)C=C4)C2=O)O",-4.096,4,11,7]
["S9064","Trilobatin","b3","L6200-24","in 10mM DMSO","HIV,Immunology & Inflammation related","Immunology & Inflammation","Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.",436.41,"4192-90-9",{"v":10,"d":"10.00"},22.91,"N/A","N/A","https://www.selleckchem.com/products/trilobatin.html","C21H24O10","free base","P-Phlorizin","OCC1OC(OC2=CC(=C(C(=O)CCC3=CC=C(O)C=C3)C(=C2)O)O)C(O)C(O)C1O",0.827,3,7,7]
["S9070","Isoxanthohumol","c3","L6200-24","in 10mM DMSO","HSV","Microbiology","Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).",{"v":354.4,"d":"354.40"},"70872-29-6",{"v":10,"d":"10.00"},28.22,"N/A","N/A","https://www.selleckchem.com/products/isoxanthohumol.html","C21H22O5","free base","FI45719","COC1=CC(=C(CC=C(C)C)C2=C1C(=O)CC(O2)C3=CC=C(O)C=C3)O",4.456,3,2,4]
["S9071","Nootkatone","d3","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.",218.33,"4674-50-4","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/nootkatone.html","C15H22O","free base","N/A","CC1CC(=O)C=C2CCC(CC12C)C(C)=C",3.751,1,0,1]
["S9077","Plantamajoside","e3","L6200-24","in 10mM DMSO","Others","Others","Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential.",640.59,"104777-68-6",{"v":10,"d":"10.00"},15.61,"N/A","N/A","https://www.selleckchem.com/products/plantamajoside.html","C29H36O16","free base","Y0160, C10485","OCC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(CO)C2OC(=O)\\C=C\\C4=CC=C(O)C(=C4)O)C(O)C(O)C1O",-0.404,6,10,12]
["S9080","Anhydroicaritin","f3","L6200-24","in 10mM DMSO","Others","Apoptosis","Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.",368.38,"118525-40-9",{"v":10,"d":"10.00"},27.15,"N/A","N/A","https://www.selleckchem.com/products/anhydroicaritin.html","C21H20O6","free base","Cycloicaritin","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C(=C3O2)CC=C(C)C",3.954,3,3,4]
["S9084","Rhoifolin","g3","L6200-24","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.",578.52,"17306-46-6",{"v":10,"d":"10.00"},17.29,"N/A","N/A","https://www.selleckchem.com/products/rhoifolin.html","C27H30O14","free base","Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside","CC1OC(OC2C(O)C(O)C(CO)OC2OC3=CC4=C(C(=C3)O)C(=O)C=C(O4)C5=CC=C(O)C=C5)C(O)C(O)C1O",-0.378,6,8,6]
["S9085","Corynoline","h3","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.",{"v":367.4,"d":"367.40"},"18797-79-0",{"v":10,"d":"10.00"},27.22,"N/A","N/A","https://www.selleckchem.com/products/corynoline.html","C21H21NO5","free base","N/A","CN1CC2=C(C=CC3=C2OCO3)C4(C)C(O)CC5=C(C=C6OCOC6=C5)C14",2.732,4,1,0]
["S9088","Calycosin-7-O-beta-D-glucoside","a4","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.",{"v":446.4,"d":"446.40"},"20633-67-4",{"v":10,"d":"10.00"},{"v":22.4,"d":"22.40"},"N/A","N/A","https://www.selleckchem.com/products/calycosin-7-o-beta-d-glucoside.html","C22H22O10","free base","N/A","COC1=C(O)C=C(C=C1)C2=COC3=C(C=CC(=C3)OC4OC(CO)C(O)C(O)C4O)C2=O",0.436,5,5,5]
["S9089","Magnoflorine","b4","L6200-24","in 10mM DMSO","Tyrosinase","Proteases","Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.",342.41,"2141-09-5",{"v":10,"d":"10.00"},{"v":29.2,"d":"29.20"},"N/A","N/A","https://www.selleckchem.com/products/magnoflorine.html","C20H24NO4","free base","Escholin, Thalictrin","COC1=C(O)C2=C(CC3C4=C2C(=C(OC)C=C4CC[N+]3(C)C)O)C=C1",1.728,2,2,2]
["S9091","10-Gingerol","c4","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.",350.49,"23513-15-7",{"v":10,"d":"10.00"},28.53,"N/A","N/A","https://www.selleckchem.com/products/10-gingerol.html","C21H34O4","free base","N/A","CCCCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",5.463,2,2,14]
["S9094","Pogostone","d4","L6200-24","in 10mM DMSO","Anti-infection","Microbiology","Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.",224.25,"23800-56-8","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/pogostone.html","C12H16O4","free base","N/A","CC(C)CCC(=O)C1=C(O)C=C(C)OC1=O",1.821,3,1,4]
["S9095","Senegenin","e4","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.",537.13,"2469-34-3",{"v":10,"d":"10.00"},18.62,"N/A","N/A","https://www.selleckchem.com/products/senegenin.html","C30H45ClO6","free base","Tenuigenin","CC1(C)CCC2(CCC3=C(C(CCl)CC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O",{"v":4.91,"d":"4.910"},2,2,3]
["S9098","Dehydrodiisoeugenol","f4","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.",326.39,"2680-81-1",{"v":65,"d":"65.00"},199.15,"N/A","N/A","https://www.selleckchem.com/products/dehydrodiisoeugenol.html","C20H22O4","free base","N/A","COC1=C(O)C=CC(=C1)C2OC3=C(C=C(\\C=C\\C)C=C3OC)C2C",4.499,3,1,4]
["S9100","Fraxinellone","g4","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.",232.27,"28808-62-0",{"v":46,"d":"46.00"},198.04,"N/A","N/A","https://www.selleckchem.com/products/fraxinellone.html","C14H16O3","free base","N/A","CC1=C2C(=O)OC(C3=COC=C3)C2(C)CCC1",2.995,3,0,1]
["S9105","Ginsenoside CK","h4","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent.",622.87,"39262-14-1",{"v":100,"d":"100.00"},160.55,"N/A","N/A","https://www.selleckchem.com/products/ginsenoside-ck.html","C36H62O8","free base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CCC34C",4.042,2,6,7]
["S9106","Eleutheroside E","a5","L6200-24","in 10mM DMSO","Immunology & Inflammation related,NF-κB","NF-κB","Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.",742.72,"39432-56-9",{"v":10,"d":"10.00"},13.46,"N/A","N/A","https://www.selleckchem.com/products/eleutheroside-e.html","C34H46O18","free base","N/A","COC1=C(OC2OC(CO)C(O)C(O)C2O)C(=CC(=C1)C3OCC4C3COC4C5=CC(=C(OC6OC(CO)C(O)C(O)C6O)C(=C5)OC)OC)OC",-1.709,10,8,12]
["S9107","Glycitein","b5","L6200-24","in 10mM DMSO","ROS","Immunology & Inflammation","Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.",284.26,"40957-83-3",{"v":10,"d":"10.00"},35.18,"N/A","N/A","https://www.selleckchem.com/products/glycitein.html","C16H12O5","free base","N/A","COC1=CC2=C(OC=C(C2=O)C3=CC=C(O)C=C3)C=C1O",2.366,3,2,2]
["S9108","Timosaponin A3","c5","L6200-24","in 10mM DMSO","Others","Others","Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity.",740.92,"41059-79-4",{"v":100,"d":"100.00"},134.97,"N/A","N/A","https://www.selleckchem.com/products/timosaponin-a3.html","C39H64O13","free base","Filiferin B, AneMarsaponin A3","CC1CCC2(OC1)OC3CC4C5CCC6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O",{"v":1.39,"d":"1.390"},6,7,6]
["S9112","Kaempferitrin","d5","L6200-24","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.",578.52,"482-38-2",{"v":100,"d":"100.00"},172.86,"N/A","N/A","https://www.selleckchem.com/products/kaempferitrin.html","C27H30O14","free base","Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside","CC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(O)C=C4)OC5OC(C)C(O)C(O)C5O)C(O)C(O)C1O",-0.211,6,8,5]
["S9114","Polyphyllin I","e5","L6200-24","in 10mM DMSO","JNK","MAPK","Polyphyllin I, a small molecular monomer extracted from Rhizoma of Paris polyphyllin, is used in the treatment of infectious disease and cancer. Polyphyllin I inhibits proliferation and induces apoptotic cell death in U251 cells. Polyphyllin I is an activator of the JNK signaling pathway with a potential anti-glioma effect.",855.02,"50773-41-6",{"v":100,"d":"100.00"},116.96,"N/A","N/A","https://www.selleckchem.com/products/polyphyllin-i.html","C44H70O16","free base","N/A","CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(CO)C(O)C8O)C(O)C7OC9OC(C)C(O)C(O)C9O",0.792,8,8,8]
["S9115","Wogonoside","f5","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.",460.39,"51059-44-0",{"v":38,"d":"38.00"},82.54,"N/A","N/A","https://www.selleckchem.com/products/wogonoside.html","C22H20O11","free base","Oroxindin, Wogonin 7-O-glucuronide, Glychionide B","COC1=C(OC2OC(C(O)C(O)C2O)C(O)=O)C=C(O)C3=C1OC(=CC3=O)C4=CC=CC=C4",0.833,6,4,5]
["S9120","Scutellarein","g5","L6200-24","in 10mM DMSO","Antiviral,Immunology & Inflammation related","Immunology & Inflammation","Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities",286.24,"529-53-3",{"v":57,"d":"57.00"},199.14,"N/A","N/A","https://www.selleckchem.com/products/scutellarein.html","C15H10O6","free base/salt","6-Hydroxyapigenin","OC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C(=C3O)O",2.168,2,4,1]
["S9121","Irigenin","h5","L6200-24","in 10mM DMSO","Others","Others","Irigenin, an O-methylated isoflavone, can be isolated from the rhizomes of the leopard lily (Belamcanda chinensis), and Iris kemaonensis.",360.31,"548-76-5",{"v":72,"d":"72.00"},199.83,"N/A","N/A","https://www.selleckchem.com/products/irigenin.html","C18H16O8","free base","N/A","COC1=C(OC)C(=CC(=C1)C2=COC3=CC(=C(OC)C(=C3C2=O)O)O)O",2.091,5,3,4]
["S9125","Apigetrin","a6","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.",432.38,"578-74-5",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/apigetrin.html","C21H20O10","free base","Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside","OCC1OC(OC2=CC3=C(C(=C2)O)C(=O)C=C(O3)C4=CC=C(O)C=C4)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9126","Schizandrol B","b6","L6200-24","in 10mM DMSO","Others","Others","Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.",416.46,"58546-54-6",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/schizandrol-b.html","C23H28O7","free base","Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin","COC1=CC2=C(C(=C1OC)OC)C3=C(CC(C)C(C)(O)C2)C=C4OCOC4=C3OC",3.851,6,0,4]
["S9129","20(S)-Ginsenoside Rh1","c6","L6200-24","in 10mM DMSO","Immunology & Inflammation related,Interleukins,PPAR,TNF-alpha","Immunology & Inflammation","20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.",638.87,"63223-86-9",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/20-s-ginsenoside-rh1.html","C36H62O9","free base","Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(CC23C)OC5OC(CO)C(O)C(O)C5O",2.873,2,6,7]
["S9136","Neochlorogenic acid","d6","L6200-24","in 10mM DMSO","Antiviral,Bacterial,Immunology & Inflammation related","Immunology & Inflammation","Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.",354.31,"906-33-2",{"v":70,"d":"70.00"},197.57,"N/A","N/A","https://www.selleckchem.com/products/neochlorogenic-acid.html","C16H18O9","free base","Neochlorogenate, 5-O-Caffeoylquinic acid","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S9141","Berbamine","e6","L6200-24","in 10mM DMSO","Apoptosis related,Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",608.72,"478-61-5",{"v":100,"d":"100.00"},164.28,"N/A","N/A","https://www.selleckchem.com/products/berbamine.html","C37H40N2O6","free base","BA, BBM","COC1=C2OC3=C4C(CC5=CC=C(O)C(=C5)OC6=CC=C(CC7N(C)CCC(=C1)C7=C2)C=C6)N(C)CCC4=CC(=C3OC)OC",6.992,5,1,3]
["S9146","Anwuligan","f6","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.",{"v":328.4,"d":"328.40"},"107534-93-0",{"v":65,"d":"65.00"},197.93,"N/A","N/A","https://www.selleckchem.com/products/anwuligan.html","C20H24O4","free base","Macelignan","COC1=C(O)C=CC(=C1)CC(C)C(C)CC2=CC3=C(OCO3)C=C2",5.186,3,1,6]
["S9148","Peiminine","g6","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.",429.64,"18059-10-4",{"v":85.9,"d":"85.90"},199.94,"N/A","N/A","https://www.selleckchem.com/products/peiminine.html","C27H43NO3","free base","Verticinone, Zhebeinone, Raddeanine","CC1CCC2N(C1)CC3C4CC5C(CC(=O)C6CC(O)CCC56C)C4CCC3C2(C)O",3.354,1,1,0]
["S9149","Benzoylpaeoniflorin","h6","L6200-24","in 10mM DMSO","COX","Immunology & Inflammation","Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.",584.57,"38642-49-8",{"v":100,"d":"100.00"},171.07,"N/A","N/A","https://www.selleckchem.com/products/benzoylpaeoniflorin.html","C30H32O12","free base","N/A","CC12CC3(O)OC(O1)C4(COC(=O)C5=CC=CC=C5)C3CC24OC6OC(COC(=O)C7=CC=CC=C7)C(O)C(O)C6O",{"v":0.76,"d":"0.760"},8,3,10]
["S9152","Epiberberine","a7","L6200-24","in 10mM DMSO","Others","Others","Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).",336.36,"6873-09-2",{"v":12,"d":"12.00"},35.68,"N/A","N/A","https://www.selleckchem.com/products/epiberberine.html","C20H18NO4","free base","N/A","COC1=C(OC)C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(OCO5)C4=C3",3.962,4,0,2]
["S9155","Aurantio-obtusin","b7","L6200-24","in 10mM DMSO","Others","Others","Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects.",330.29,"67979-25-3",{"v":66,"d":"66.00"},199.83,"N/A","N/A","https://www.selleckchem.com/products/aurantio-obtusin.html","C17H14O7","free base","N/A","COC1=C(O)C2=C(C=C1O)C(=O)C3=C(C2=O)C(=C(O)C(=C3)C)OC",2.535,4,3,2]
["S9160","Ziyu-glycoside I","c7","L6200-24","in 10mM DMSO","Others","Others","Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.",766.95,"35286-58-9",{"v":100,"d":"100.00"},130.39,"N/A","N/A","https://www.selleckchem.com/products/ziyu-glycoside-i.html","C41H66O13","free base","N/A","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1(C)O)C(=O)OC7OC(CO)C(O)C(O)C7O",2.178,5,7,6]
["S9163","Rhapontigenin","d7","L6200-24","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).",258.27,"500-65-2",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/rhapontigenin.html","C15H14O4","free base","Protigenin","COC1=CC=C(/C=C/C2=CC(=CC(=C2)O)O)C=C1O",3.073,1,3,3]
["S9167","Columbin","e7","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug.",358.39,"546-97-4",{"v":71,"d":"71.00"},198.11,"N/A","N/A","https://www.selleckchem.com/products/columbin.html","C20H22O6","free base","N/A","CC12CC(OC(=O)C1CCC3(C)C2C4OC(=O)C3(O)C=C4)C5=COC=C5",1.849,5,0,1]
["S9170","Engeletin","f7","L6200-24","in 10mM DMSO","NF-κB","NF-κB","Engeletin (Dihydrokaempferol 3-rhamnoside), a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects. engeletin againsts LPS-stimulated endometritis in mice via negative regulation of pro-inflammatory mediators via the TLR4-regulated NF-κB pathway.",434.39,"572-31-6",{"v":86,"d":"86.00"},197.98,"N/A","N/A","https://www.selleckchem.com/products/engeletin.html","C21H22O10","free base","Dihydrokaempferol 3-rhamnoside","CC1OC(OC2C(OC3=C(C(=CC(=C3)O)O)C2=O)C4=CC=C(O)C=C4)C(O)C(O)C1O",0.862,4,6,3]
["S9172","Phellodendrine","g7","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.",342.41,"6873-13-8",{"v":42.6,"d":"42.60"},124.41,"N/A","N/A","https://www.selleckchem.com/products/phellodendrine.html","C20H24NO4","free base","N/A","COC1=C(O)C=C2C3CC4=C(C[N+]3(C)CCC2=C1)C=C(OC)C(=C4)O",1.793,2,2,2]
["S9174","Xanthotoxol","h7","L6200-24","in 10mM DMSO","5-HT Receptor,Immunology & Inflammation related","Neuronal Signaling","Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.",202.16,"2009-24-7",{"v":40,"d":"40.00"},197.86,"N/A","N/A","https://www.selleckchem.com/products/xanthotoxol.html","C11H6O4","free base","8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen","OC1=C2OC(=O)C=CC2=CC3=C1OC=C3",1.961,3,1,0]
["S9178","Sinapine thiocyanate","a8","L6200-24","in 10mM DMSO","Others","Immunology & Inflammation","Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.",368.45,"7431-77-8",{"v":73,"d":"73.00"},198.13,"N/A","N/A","https://www.selleckchem.com/products/sinapine-thiocyanate.html","C17H24N2O5S","free base","N/A","COC1=CC(=CC(=C1O)OC)/C=C/C(=O)OCC[N+](C)(C)C.[S-]C#N",1.287,4,1,8]
["S9184","Forsythoside B","b8","L6200-24","in 10mM DMSO","Immunology & Inflammation related,Interleukins,IκB/IKK,NF-κB,TNF-alpha","Immunology & Inflammation","Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.",{"v":756.7,"d":"756.70"},"81525-13-5",{"v":100,"d":"100.00"},132.15,"N/A","N/A","https://www.selleckchem.com/products/forsythoside-b.html","C34H44O19","free base","N/A","CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(=C3)O)OC(COC4OCC(O)(CO)C4O)C2OC(=O)/C=C/C5=CC(=C(O)C=C5)O)C(O)C(O)C1O",-0.925,8,10,14]
["S9189","Oroxin A","c8","L6200-24","in 10mM DMSO","PPAR","Metabolism","Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.",432.38,"57396-78-8",{"v":86,"d":"86.00"},{"v":198.9,"d":"198.90"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-a.html","C21H20O10","free base","Baicalein 7-O-glucoside","OCC1OC(OC2=CC3=C(C(=O)C=C(O3)C4=CC=CC=C4)C(=C2O)O)C(O)C(O)C1O",{"v":0.48,"d":"0.480"},4,6,4]
["S9190","Oroxin B","d8","L6200-24","in 10mM DMSO","Akt,Apoptosis related,COX,PI3K,PTEN","Apoptosis","Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.",594.52,"114482-86-9",{"v":100,"d":"100.00"},{"v":168.2,"d":"168.20"},"N/A","N/A","https://www.selleckchem.com/products/oroxin-b.html","C27H30O15","free base","Hypocretin-2","OCC1OC(OCC2OC(OC3=C(O)C(=C4C(=O)C=C(OC4=C3)C5=CC=CC=C5)O)C(O)C(O)C2O)C(O)C(O)C1O",-1.267,6,9,7]
["S9193","Aristolochic acid A","e8","L6200-24","in 10mM DMSO","AP-1,NF-κB","NF-κB","Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae.Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities.",341.27,"313-67-7",{"v":6,"d":"6.00"},17.58,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/aristolochic-acid-a.html","C17H11NO7","Free Base","Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736","COC1=CC=CC2=C3C4=C(OCO4)C=C(C(O)=O)C3=C(C=C12)[N+]([O-])=O",2.922,4,0,3]
["S9204","Oroxylin A","f8","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.",284.26,"480-11-5",{"v":56.9,"d":"56.90"},200.17,"N/A","N/A","https://www.selleckchem.com/products/oroxylin-a.html","C16H12O5","free base","6-Methoxybaicalein","COC1=C(O)C2=C(OC(=CC2=O)C3=CC=CC=C3)C=C1O",2.636,3,2,2]
["S9211","Eriocitrin","g8","L6200-24","in 10mM DMSO","Others","Others","Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.",596.53,"13463-28-0",{"v":100,"d":"100.00"},167.64,"N/A","N/A","https://www.selleckchem.com/products/eriocitrin.html","C27H32O15","free base","eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside","CC1OC(OCC2OC(OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(O)C(=C5)O)O)C(O)C(O)C2O)C(O)C(O)C1O",-0.657,6,9,6]
["S9221","Ferulaldehyde","h8","L6200-24","in 10mM DMSO","Heme Oxygenase","Immunology & Inflammation","Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.",178.18,"458-36-6",{"v":35,"d":"35.00"},196.43,"N/A","N/A","https://www.selleckchem.com/products/ferulaldehyde.html","C10H10O3","free base","Coniferaldehyde, Ferulyl aldehyde","COC1=CC(=CC=C1O)\\C=C\\C=O",1.691,2,1,3]
["S9225","Santalol","a9","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.",220.35,"11031-45-1","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/santalol.html","C15H24O","free base","N/A","CC(\\CO)=C/CCC1(C)C2CCC(C2)C1=C",3.662,0,1,4]
["S9228","Schisandrin C","b9","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.",384.42,"61301-33-5",{"v":76.9,"d":"76.90"},200.04,"N/A","N/A","https://www.selleckchem.com/products/schisandrin-c.html","C22H24O6","free base","N/A","COC1=C2OCOC2=CC3=C1C4=C(CC(C)C(C)C3)C=C5OCOC5=C4OC",4.868,6,0,2]
["S9231","Schisanhenol","c9","L6200-24","in 10mM DMSO","Transferase","Metabolism","Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.",402.48,"69363-14-0",{"v":81,"d":"81.00"},201.25,"N/A","N/A","https://www.selleckchem.com/products/schisanhenol.html","C23H30O6","free base","Gomisin K3","COC1=C(OC)C(=C2C(=C1)CC(C)C(C)CC3=CC(=C(OC)C(=C23)OC)OC)O",5.041,5,1,5]
["S9234","Schaftoside","d9","L6200-24","in 10mM DMSO","Lipase,MyD88,TLR","Metabolism","Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.",564.49,"51938-32-0",{"v":100,"d":"100.00"},177.15,"N/A","N/A","https://www.selleckchem.com/products/schaftoside.html","C26H28O14","free base","N/A","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC=C(O)C=C4)C(=C2O)C5OCC(O)C(O)C5O",-1.862,4,10,4]
["S9236","α-Cyperone","e9","L6200-24","in 10mM DMSO","COX,Interleukins","Immunology & Inflammation","α-Cyperone (alpha-cyperone), a major active compound of Cyperus rotundus, exhibits biological activities, such as antivirulence, antigenotoxic, and antibacterial activities. α-Cyperone (alpha-cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1.",218.33,"473-08-5","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/alpha-cyperone.html","C15H22O","free base","N/A","CC(=C)C1CCC2(C)CCC(=O)C(=C2C1)C",3.946,1,0,1]
["S9240","Isofraxidin","f9","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.",222.19,"486-21-5",{"v":44,"d":"44.00"},198.03,"N/A","N/A","https://www.selleckchem.com/products/isofraxidin.html","C11H10O5","free base","6,8-Dimethoxyumbelliferone","COC1=CC2=C(OC(=O)C=C2)C(=C1O)OC",1.625,4,1,2]
["S9241","Polygalaxanthone III","g9","L6200-24","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Polygalaxanthone III is a natural product with the efficacy of tranquilization, glaangal, eliminating sputum and detumescence. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM.",568.48,"162857-78-5",{"v":100,"d":"100.00"},175.91,"N/A","N/A","https://www.selleckchem.com/products/polygalaxanthone-iii.html","C25H28O15","free base","N/A","COC1=CC2=C(OC3=C(C(=C(C4OC(COC5OCC(O)(CO)C5O)C(O)C(O)C4O)C(=C3)O)O)C2=O)C=C1O",-1.579,6,8,6]
["S9243","Protosappanin B","h9","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.",304.29,"102036-29-3",{"v":61,"d":"61.00"},200.46,"N/A","N/A","https://www.selleckchem.com/products/protosappanin-b.html","C16H16O6","free base","FT-0689654, Q-100961","OCC1(O)COC2=CC(=CC=C2C3=CC(=C(O)C=C3C1)O)O",1.486,1,4,1]
["S9250","Isosilybin","a10","L6200-24","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Isosilybin (Silymarin, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.",482.44,"72581-71-6",{"v":97,"d":"97.00"},201.06,"N/A","N/A","https://www.selleckchem.com/products/isosilybin.html","C25H22O10","free base","Silymarin, Isosilybinin, Q-100795","COC1=C(O)C=CC(=C1)C2OC3=C(OC2CO)C=C(C=C3)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O",2.592,5,5,4]
["S9259","Lithospermic acid","b10","L6200-24","in 10mM DMSO","Others","Others","Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects.",538.46,"28831-65-4",{"v":100,"d":"100.00"},185.72,"N/A","N/A","https://www.selleckchem.com/products/lithospermic-acid.html","C27H22O12","free base","N/A","OC(=O)C(CC1=CC(=C(O)C=C1)O)OC(=O)/C=C/C2=CC=C(O)C3=C2C(C(O3)C4=CC(=C(O)C=C4)O)C(O)=O",3.454,5,5,9]
["S9263","3-n-Butylphathlide","c10","L6200-24","in 10mM DMSO","Others","Others","3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.",190.24,"6066-49-5","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/3-n-butylphathlide.html","C12H14O2","free base","N/A","CCCCC1OC(=O)C2=C1C=CC=C2",3.252,2,0,3]
["S9265","7-Epitaxol","d10","L6200-24","in 10mM DMSO","Others","Others","7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug.",853.91,"105454-04-4",{"v":100,"d":"100.00"},117.11,"N/A","N/A","https://www.selleckchem.com/products/7-epitaxol.html","C47H51NO14","free base/salt","7-Epipaclitaxel","CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C1C5(C)C)C",3.055,11,3,14]
["S9272","Koumine","e10","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.",{"v":306.4,"d":"306.40"},"1358-76-5",{"v":15,"d":"15.00"},48.96,"N/A","N/A","https://www.selleckchem.com/products/koumine.html","C20H22N2O","free base","N/A","CN1CC2(C=C)C3CC4OCC3C1CC25C4=NC6=CC=CC=C56",1.879,2,0,1]
["S9274","Isochlorogenic acid B","f10","L6200-24","in 10mM DMSO","Others","Others","Isochlorogenic acid B, naturally isolated from Laggera alata, has antioxidative and hepatoprotective properties.",516.45,"14534-61-3",{"v":100,"d":"100.00"},193.63,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-b.html","C25H24O12","free base","N/A","OC1CC(O)(CC(OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C1OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,5,9]
["S9275","Isoguanosine","g10","L6200-24","in 10mM DMSO","FLT3,HDAC","Angiogenesis","Isoguanosine (Crotonoside) inhibits FLT3 and HDAC3/6 for the treatment of AML.Isoguanosine is a naturally occurring active isomer of guanosine that is found in the seeds of Croton tiglium.",283.24,"1818-71-9",{"v":57,"d":"57.00"},201.24,"N/A","N/A","https://www.selleckchem.com/products/isoguanosine.html","C10H13N5O5","free base","Crotonoside","NC1=NC(=O)NC2=C1N=C[N]2C3OC(CO)C(O)C3O",{"v":-2.38,"d":"-2.380"},4,5,2]
["S9280","Demethoxycurcumin","h10","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.",338.35,"22608-11-3",{"v":68,"d":"68.00"},200.97,"N/A","N/A","https://www.selleckchem.com/products/demethoxycurcumin.html","C20H18O5","free base","N/A","COC1=CC(=CC=C1O)\\C=C\\C(=O)CC(=O)\\C=C\\C2=CC=C(O)C=C2",{"v":3.57,"d":"3.570"},3,2,7]
["S9282","Isochlorogenic acid A","a11","L6200-24","in 10mM DMSO","Others","Others","Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities.",516.45,"2450-53-5",{"v":100,"d":"100.00"},193.63,"N/A","N/A","https://www.selleckchem.com/products/isochlorogenic-acid-a.html","C25H24O12","free base","3,5-dicaffeoylquinic acid","OC1C(CC(O)(CC1OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C(O)=O)OC(=O)\\C=C\\C3=CC(=C(O)C=C3)O",1.687,5,5,9]
["S9284","Aloesin","b11","L6200-24","in 10mM DMSO","Tyrosinase","Proteases","Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.",394.37,"30861-27-9",{"v":78,"d":"78.00"},197.78,"N/A","N/A","https://www.selleckchem.com/products/aloesin.html","C19H22O9","free base","Aloe resin B","CC(=O)CC1=CC(=O)C2=C(C)C=C(O)C(=C2O1)C3OC(CO)C(O)C(O)C3O",-0.765,4,5,4]
["S9292","Dictamnine","c11","L6200-24","in 10mM DMSO","Bacterial","Microbiology","Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi.",199.21,"484-29-7",{"v":33,"d":"33.00"},165.66,"N/A","N/A","https://www.selleckchem.com/products/dictamnine.html","C12H9NO2","free base","N/A","COC1=C2C=COC2=NC3=C1C=CC=C3",2.502,3,0,1]
["S9293","Isoliquiritin","d11","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.",418.39,"5041-81-6",{"v":84,"d":"84.00"},200.77,"N/A","N/A","https://www.selleckchem.com/products/isoliquiritin.html","C21H22O9","free base","Neoisoliquritin","OCC1OC(OC2=CC=C(\\C=C\\C(=O)C3=C(O)C=C(O)C=C3)C=C2)C(O)C(O)C1O",1.046,3,6,6]
["S9298","Corylin","e11","L6200-24","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.",320.34,"53947-92-5",{"v":64,"d":"64.00"},199.79,"N/A","N/A","https://www.selleckchem.com/products/corylin.html","C20H16O4","free base","N/A","CC1(C)OC2=CC=C(C=C2C=C1)C3=COC4=CC(=CC=C4C3=O)O",3.412,3,1,1]
["S9299","Ginsenoside F1","f11","L6200-24","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Ginsenoside F1, a pharmaceutical component of ginseng, is known to have antiaging, antioxidant, anticancer, and keratinocyte protective effects. Ginsenoside F1 exhibits competitive inhibition of the activity of CYP3A4 with Ki values of 67.8 ± 16.2 μM. Ginsenoside F1 also exhibited a weaker inhibition of the activity of CYP2D6.",638.87,"53963-43-2",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/ginsenoside-f1.html","C36H62O9","free base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(O)CC34C",2.873,2,7,7]
["S9312","Cyanidin-3-O-glucoside chloride","g11","L6200-24","in 10mM DMSO","Others","Others","Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects.",484.84,"7084-24-4",{"v":97,"d":"97.00"},200.07,"N/A","N/A","https://www.selleckchem.com/products/cyanidin-3-o-glucoside-chloride.html","C21H21ClO11","free base","Kuromanin chloride, Chrysontemin chloride, Glucocyanidin chloride","[Cl-].OCC1OC(OC2=C([O+]=C3C=C(O)C=C(O)C3=C2)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",-1.566,2,8,4]
["S9315","Praeruptorin A","h11","L6200-24","in 10mM DMSO","Akt,Calcium Channel,p38 MAPK","PI3K/Akt/mTOR","Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.",{"v":386.4,"d":"386.40"},"73069-25-7",{"v":77,"d":"77.00"},199.28,"N/A","N/A","https://www.selleckchem.com/products/praeruptorin-a-1.html","C21H22O7","free base","N/A","C\\C=C(C)/C(=O)OC1C(OC(C)=O)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3",3.502,7,0,5]
["S9318","(20R)-Ginsenoside Rh1","a2","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","(20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.",638.87,"80952-71-2",{"v":100,"d":"100.00"},156.53,"N/A","N/A","https://www.selleckchem.com/products/20r-ginsenoside-rh1.html","C36H62O9","free base","N/A","CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC3C4(C)CCC(O)C(C)(C)C4C(CC23C)OC5OC(CO)C(O)C(O)C5O",2.873,2,6,7]
["S9319","Cryptochlorogenic acid","b2","L6200-25","in 10mM DMSO","Others","Others","Cryptochlorogenic acid (4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid), a phenolic acid found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, possesses antioxidant properties.",354.31,"905-99-7",{"v":71,"d":"71.00"},200.39,"N/A","N/A","https://www.selleckchem.com/products/cryptochlorogenic-acid.html","C16H18O9","free base","4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid","OC1CC(O)(CC(O)C1OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O)C(O)=O",{"v":-0.34,"d":"-0.340"},3,4,5]
["S9322","Neodiosmin","c2","L6200-25","in 10mM DMSO","Others","Others","Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.",608.54,"38665-01-9",{"v":100,"d":"100.00"},164.33,"N/A","N/A","https://www.selleckchem.com/products/neodiosmin.html","C28H32O15","free base","Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside","COC1=CC=C(C=C1O)C2=CC(=O)C3=C(O2)C=C(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)C=C3O",-0.395,7,8,7]
["S9329","Orcinol","d2","L6200-25","in 10mM DMSO","Others","Others","Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects.",124.14,"504-15-4",{"v":24,"d":"24.00"},193.33,"N/A","N/A","https://www.selleckchem.com/products/orcinol.html","C7H8O2","free base","5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene","CC1=CC(=CC(=C1)O)O",1.832,0,2,0]
["S9338","Octyl gallate","e2","L6200-25","in 10mM DMSO","Others","Microbiology","Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.",282.33,"1034-01-1",{"v":56,"d":"56.00"},198.35,"N/A","N/A","https://www.selleckchem.com/products/octyl-gallate.html","C15H22O5","free base","Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester","CCCCCCCCOC(=O)C1=CC(=C(O)C(=C1)O)O",4.112,2,3,9]
["S9341","3,4-Dimethoxycinnamic acid","f2","L6200-25","in 10mM DMSO","Anti-infection","Microbiology","3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.",208.21,"2316-26-9",{"v":42,"d":"42.00"},201.72,"N/A","N/A","https://www.selleckchem.com/products/3-4-dimethoxycinnamic-acid.html","C11H12O4","free base","Caffeic acid dimethyl ether","COC1=CC=C(/C=C/C(O)=O)C=C1OC",1.894,3,0,4]
["S9350","Ethyl 4-Methoxycinnamate","g2","L6200-25","in 10mM DMSO","Fungal","Microbiology","Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.",206.24,"24393-56-4",{"v":41,"d":"41.00"},{"v":198.8,"d":"198.80"},"N/A","N/A","https://www.selleckchem.com/products/ethyl-4-methoxycinnamate.html","C12H14O3","free base","Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester, Ethyl methoxycinnamate, Ethyl para-methoxycinnamate","CCOC(=O)\\C=C\\C1=CC=C(OC)C=C1",2.485,3,0,5]
["S9355","2,4'-Dihydroxybenzophenone","h2","L6200-25","in 10mM DMSO","Others","Others","2,4'-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents.",214.22,"606-12-2",{"v":43,"d":"43.00"},200.73,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/2-4-dihydroxybenzophenone.html","C13H10O3","Free Base","N/A","OC1=CC=C(C=C1)C(=O)C2=CC=CC=C2O",{"v":2.75,"d":"2.750"},1,2,2]
["S9360","4-Hydroxyquinazoline","a3","L6200-25","in 10mM DMSO","PARP","DNA Damage/DNA Repair","4-Hydroxyquinazoline (Quinazolin-4-ol, 4-Quinazolinol) is a PARP inhibitor with a high potency for PARP-1 with IC50 of 9.5 μM.",146.15,"491-36-1",{"v":29,"d":"29.00"},198.43,"N/A","N/A","https://www.selleckchem.com/products/4-hydroxyquinazoline-.html","C8H6N2O","free base","Quinazolin-4-ol, 4-Quinazolinol","O=C1NC=NC2=CC=CC=C12",{"v":0.75,"d":"0.750"},2,1,0]
["S9374","2',5'-Dihydroxyacetophenone","b3","L6200-25","in 10mM DMSO","ERK,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.",152.15,"490-78-8",{"v":30,"d":"30.00"},197.18,"N/A","N/A","https://www.selleckchem.com/products/2-5-dihydroxyacetophenone.html","C8H8O3","free base","DHAP, 2-Acetylhydroquinone, Quinacetophenone","CC(=O)C1=C(O)C=CC(=C1)O",1.085,1,2,1]
["S9379","Dihydrocoumarin","c3","L6200-25","in 10mM DMSO","Others","Others","Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps.",148.16,"119-84-6","N/A","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","https://www.selleckchem.com/products/dihydrocoumarin.html","C9H8O2","free base","N/A","O=C1CCC2=C(O1)C=CC=C2",1.923,2,0,0]
["S9384","Sophocarpine Monohydrate","d3","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.",264.36,"145572-44-7",{"v":52,"d":"52.00"},{"v":196.7,"d":"196.70"},"N/A","N/A","https://www.selleckchem.com/products/sophocarpine-monohydrate.html","C15H24N2O2","free base","N/A","O.O=C1C=CCC2C3CCCN4CCCC(CN12)C34",1.187,1,0,0]
["S9397","Alliin","e3","L6200-25","in 10mM DMSO","Others","Others","Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.",177.22,"556-27-4",{"v":3,"d":"3.00"},16.93,"N/A","N/A","https://www.selleckchem.com/products/alliin.html","C6H11NO3S","free base","S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine","NC(C[S](=O)CC=C)C(O)=O",-3.391,2,1,5]
["S9399","1,2,3,4,6-O-Pentagalloylglucose","f3","L6200-25","in 10mM DMSO","Others","Others","1,2,3,4,6-O-Pentagalloylglucose is the pentagallic acid ester of glucose. It could be used for precipitating proteins.",940.68,"14937-32-7",{"v":100,"d":"100.00"},106.31,"N/A","N/A","https://www.selleckchem.com/products/o-pentagalloylglucose.html","C41H32O26","free base","N/A","OC1=C(O)C(=CC(=C1)C(=O)OCC2OC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(OC(=O)C4=CC(=C(O)C(=C4)O)O)C(OC(=O)C5=CC(=C(O)C(=C5)O)O)C2OC(=O)C6=CC(=C(O)C(=C6)O)O)O",4.073,11,15,16]
["S9400","Rhynchophylline","g3","L6200-25","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.",384.47,"76-66-4",{"v":76,"d":"76.00"},197.68,"N/A","N/A","https://www.selleckchem.com/products/rhynchophylline.html","C22H28N2O4","free base","Mitrinermine","CCC1CN2CCC3(C2CC1\\C(=C/OC)C(=O)OC)C(=O)NC4=CC=CC=C34",2.103,4,1,5]
["S9401","3,6'-Disinapoyl sucrose","h3","L6200-25","in 10mM DMSO","Others","Others","3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.",754.69,"139891-98-8",{"v":100,"d":"100.00"},132.51,"N/A","N/A","https://www.selleckchem.com/products/3-6-disinapoyl-sucrose.html","C34H42O19","free base","Disinapoyl sucrose","COC1=CC(=CC(=C1O)OC)\\C=C\\C(=O)OCC2OC(OC3(CO)OC(CO)C(O)C3OC(=O)/C=C/C4=CC(=C(O)C(=C4)OC)OC)C(O)C(O)C2O",0.162,11,8,17]
["S9403","Ecliptasaponin A","a4","L6200-25","in 10mM DMSO","Others","Others","Ecliptasaponin A, a natural triterpenoid glucoside, has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition.",634.84,"78285-90-2",{"v":100,"d":"100.00"},157.52,"N/A","N/A","https://www.selleckchem.com/products/ecliptasaponin-a.html","C36H58O9","free base","N/A","CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C)C2C1)C(O)=O",3.598,3,5,4]
["S9406","Sauchinone","b4","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.",356.37,"177931-17-8",{"v":27,"d":"27.00"},75.76,"N/A","N/A","https://www.selleckchem.com/products/sauchinone.html","C20H20O6","free base","N/A","CC1CC2C3C(C1C)C4=C(OC35OCOC5=CC2=O)C=C6OCOC6=C4",2.787,6,0,0]
["S9407","Angoroside C","c4","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.",784.75,"115909-22-3",{"v":100,"d":"100.00"},127.43,"N/A","N/A","https://www.selleckchem.com/products/angoroside-c.html","C36H48O19","free base","N/A","COC1=CC=C(CCOC2OC(COC3OCC(O)C(O)C3O)C(OC(=O)/C=C/C4=CC=C(O)C(=C4)OC)C(OC5OC(C)C(O)C(O)C5O)C2O)C=C1O",-0.301,10,9,15]
["S9411","Liensinine","d4","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.",610.74,"2586-96-1",{"v":100,"d":"100.00"},163.74,"N/A","N/A","https://www.selleckchem.com/products/liensinine.html","C37H42N2O6","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC=C(O)C(=C3)OC4=CC5=C(CCN(C)C5CC6=CC=C(O)C=C6)C=C4OC)N(C)CC2",{"v":7.02,"d":"7.020"},4,2,9]
["S9413","Yangonin","e4","L6200-25","in 10mM DMSO","Cannabinoid Receptor,Fungal","GPCR & G Protein","Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.",258.27,"500-62-9",{"v":51,"d":"51.00"},197.47,"N/A","N/A","https://www.selleckchem.com/products/yangonin.html","C15H14O4","free base","Y100550","COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=O)O2)OC",2.211,4,0,4]
["S9417","Homoplantaginin","f4","L6200-25","in 10mM DMSO","Immunology & Inflammation related,Interleukins,IκB/IKK,NF-κB,TNF-alpha","Immunology & Inflammation","Homoplantaginin (Hispidulin-7-glucoside), a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin inhibits TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.",{"v":462.4,"d":"462.40"},"17680-84-1",{"v":92,"d":"92.00"},198.96,"N/A","N/A","https://www.selleckchem.com/products/homoplantaginin.html","C22H22O11","free base","Hispidulin-7-glucoside","COC1=C(OC2OC(CO)C(O)C(O)C2O)C=C3OC(=CC(=O)C3=C1O)C4=CC=C(O)C=C4",0.464,5,6,5]
["S9418","Parishin B","g4","L6200-25","in 10mM DMSO","Others","Others","Parishin B is a dominant active ingredient originating from Gastrodia elata Blume, and has good neuroprotective effects against brain disorders.",728.65,"174972-79-3",{"v":100,"d":"100.00"},137.24,"N/A","N/A","https://www.selleckchem.com/products/parishin-b.html","C32H40O19","free base","N/A","OCC1OC(OC2=CC=C(COC(=O)CC(O)(CC(O)=O)C(=O)OCC3=CC=C(OC4OC(CO)C(O)C(O)C4O)C=C3)C=C2)C(O)C(O)C1O",-2.045,9,8,17]
["S9423","Narcissoside","h4","L6200-25","in 10mM DMSO","Others","Others","Narcissoside has antioxidant and antiproliferative activity in cancer.",624.54,"604-80-8",{"v":100,"d":"100.00"},160.12,"N/A","N/A","https://www.selleckchem.com/products/narcissoside.html","C28H32O16","free base","N/A","COC1=C(O)C=CC(=C1)C2=C(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)C(=O)C5=C(O)C=C(O)C=C5O2",-0.933,7,9,7]
["S9424","Liensinine diperchlorate","a5","L6200-25","in 10mM DMSO","Autophagy,Mitophagy","Autophagy","Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.",811.66,"5088-90-4",{"v":50,"d":"50.00"},{"v":61.6,"d":"61.60"},"N/A","N/A","https://www.selleckchem.com/products/liensinine-diperchlorate.html","C37H44Cl2N2O14","free base","N/A","COC1=CC2=C(C=C1OC)C(CC3=CC(=C(O)C=C3)OC4=C(OC)C=C5CCN(C)C(CC6=CC=C(O)C=C6)C5=C4)N(C)CC2.O[Cl](=O)(=O)=O.O[Cl](=O)(=O)=O",7.669,4,2,9]
["S9428","Brazilin","b5","L6200-25","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.",286.28,"474-07-7",{"v":57,"d":"57.00"},199.11,"N/A","N/A","https://www.selleckchem.com/products/brazilin.html","C16H14O5","free base","Natural Red 24","OC1=CC2=C(C=C1)C3C4=CC(=C(O)C=C4CC3(O)CO2)O",1.933,1,3,0]
["S9431","Dehydrocorydalin","c5","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.",366.43,"30045-16-0",{"v":73,"d":"73.00"},199.22,"N/A","N/A","https://www.selleckchem.com/products/dehydrocorydalin.html","C22H24NO4","free base","N/A","COC1=CC=C2C(=C3C4=C(CC[N+]3=CC2=C1OC)C=C(OC)C(=C4)OC)C",4.648,4,0,4]
["S9432","Ginkgolic Acid","d5","L6200-25","in 10mM DMSO","Histone Acetyltransferase,SUMO","Ubiquitin","Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).",{"v":346.5,"d":"346.50"},"22910-60-7",{"v":69,"d":"69.00"},199.13,"N/A","N/A","https://www.selleckchem.com/products/ginkgolic-acid-s9432.html","C22H34O3","free base","N/A","CCCCCC\\C=C/CCCCCCCC1=CC=CC(=C1C(O)=O)O",7.646,1,1,14]
["S9434","8-Gingerol","e5","L6200-25","in 10mM DMSO","Others","Others","8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect.",322.44,"23513-08-8",{"v":64,"d":"64.00"},198.49,"N/A","N/A","https://www.selleckchem.com/products/8-gingerol.html","C19H30O4","free base","N/A","CCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(=C1)OC",4.551,2,2,12]
["S9437","Echinatin","f5","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.",270.28,"34221-41-5",{"v":54,"d":"54.00"},199.79,"N/A","N/A","https://www.selleckchem.com/products/echinatin.html","C16H14O4","free base","N/A","COC1=CC(=CC=C1\\C=C\\C(=O)C2=CC=C(O)C=C2)O",3.201,2,2,4]
["S9440","Naringenin chalcone","g5","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.",272.25,"73692-50-9",{"v":54,"d":"54.00"},198.35,"N/A","N/A","https://www.selleckchem.com/products/naringenin-chalcone.html","C15H12O5","free base","Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone","OC1=CC=C(C=C1)/C=C/C(=O)C2=C(O)C=C(O)C=C2O",2.734,1,4,3]
["S9441","Sibiricose A5","h5","L6200-25","in 10mM DMSO","Antioxidant","Immunology & Inflammation","Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity., Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity.",518.47,"107912-97-0",{"v":100,"d":"100.00"},192.88,"N/A","N/A","https://www.selleckchem.com/products/sibiricose-a5.html","C22H30O14","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2C(O)C(CO)OC2(CO)OC3OC(CO)C(O)C(O)C3O",-2.058,6,8,10]
["S9442","Bergaptol","a6","L6200-25","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol  is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.",202.16,"486-60-2",{"v":40,"d":"40.00"},197.86,"N/A","N/A","https://www.selleckchem.com/products/bergaptol.html","C11H6O4","free base","5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin","OC1=C2C=COC2=CC3=C1C=CC(=O)O3",1.961,3,1,0]
["S9455","Isorhamnetin 3-O-neohesperoside","b6","L6200-25","in 10mM DMSO","Others","Metabolism","Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has signiﬁcant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.",624.54,"55033-90-4",{"v":100,"d":"100.00"},160.12,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/isorhamnetin-3-o-neohesperoside.html","C28H32O16","Free Base","N/A","COC1=CC(=CC=C1O)C2=C(OC3OC(CO)C(O)C(O)C3OC4OC(C)C(O)C(O)C4O)C(=O)C5=C(O2)C=C(O)C=C5O",-0.933,7,9,7]
["S9473","Nuzhenide","c6","L6200-25","in 10mM DMSO","Others","Others","Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity.",686.66,"39011-92-2",{"v":100,"d":"100.00"},145.63,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/nuzhenide.html","C31H42O17","Free Base","Specnuezhenide","COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)\\C(=C\\C)C1CC(=O)OCC3OC(OCCC4=CC=C(O)C=C4)C(O)C(O)C3O",-1.339,9,8,14]
["S9480","Raspberry Ketone","d6","L6200-25","in 10mM DMSO","PPAR","Metabolism","Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone) is a natural phenolic compound that is the primary aroma compound of red raspberries. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity.",{"v":164.2,"d":"164.20"},"5471-51-2",{"v":33,"d":"33.00"},200.97,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/raspberry-ketone.html","C10H12O2","Free Base","p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone","CC(=O)CCC1=CC=C(O)C=C1",1.809,1,1,3]
["S9487","Praeruptorin C","e6","L6200-25","in 10mM DMSO","Others","Others","Praeruptorin C is a natural compound derived from the dried roots of Peucedanum praeruptorum and has beneficial effects in suppressing osteoclast formation and resorption function. It is frequently utilized in traditional Chinese medicine for treating upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent.",428.47,"72463-77-5",{"v":86,"d":"86.00"},200.71,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/praeruptorin-c.html","C24H28O7","Free Base","N/A","C\\C=C(C)/C(=O)OC1C(OC(=O)CC(C)C)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3",4.877,7,0,7]
["S9502","Madecassic acid","f6","L6200-25","in 10mM DMSO","COX,Immunology & Inflammation related,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.",{"v":504.7,"d":"504.70"},"18449-41-7",{"v":100,"d":"100.00"},198.13,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/madecassic-acid.html","C30H48O6","Free Base","Brahmic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC34C)C2C1C)C(O)=O",3.265,1,4,2]
["S9503","Fraxetin","g6","L6200-25","in 10mM DMSO","Heme Oxygenase","Apoptosis","Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.",208.17,"574-84-5",{"v":42,"d":"42.00"},201.76,"N/A","N/A","https://www.selleckchem.com/products/fraxetin.html","C10H8O5","free base","7,8-dihydroxy-6-methoxy coumarin","COC1=CC2=C(OC(=O)C=C2)C(=C1O)O","N/A","N/A","N/A","N/A"]
["S9507","(−)-Norepinephrine","h6","L6200-25","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.",169.18,"51-41-2",{"v":11,"d":"11.00"},65.02,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/norepinephrine.html","C8H11NO3","Free Base","Arterenol, Levarterenol, L-Noradrenaline","NCC(O)C1=CC(=C(O)C=C1)O",-0.059,0,4,2]
["S9514","Rotundic acid","a7","L6200-25","in 10mM DMSO","Akt,mTOR,p38 MAPK","PI3K/Akt/mTOR","Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.",{"v":488.7,"d":"488.70"},"20137-37-5",{"v":98,"d":"98.00"},200.53,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/rotundic-acid.html","C30H48O5","Free Base","Rutundic acid","CC1CCC2(CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC34C)C2C1(C)O)C(O)=O",4.253,1,2,2]
["S9552","Farrerol","b7","L6200-25","in 10mM DMSO","Others","Immunology & Inflammation","Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.",300.31,"24211-30-1",{"v":60,"d":"60.00"},199.79,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/farrerol.html","C17H16O5","Free Base","N/A","CC1=C(O)C2=C(OC(CC2=O)C3=CC=C(O)C=C3)C(=C1O)C",3.346,2,3,1]
["S9567","Indinavir Sulfate","c7","L6200-25","in 10mM DMSO","COVID-19,HIV Protease","Microbiology","Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.",711.87,"157810-81-6",{"v":100,"d":"100.00"},140.48,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/indinavir-sulfate.html","C36H49N5O8S","Sulfate","Crixivan, L-735524, MK-639","CC(C)(C)NC(=O)C1CN(CCN1CC(O)CC(CC2=CC=CC=C2)C(=O)NC3C(O)CC4=C3C=CC=C4)CC5=CN=CC=C5.O[S](O)(=O)=O",2.475,3,4,12]
["S2931","Aurora Kinase Inhibitor III","d7","L6200-25","in 10mM DMSO","Aurora Kinase","Cell Cycle","Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively).",{"v":413.4,"d":"413.40"},"879127-16-9",{"v":83,"d":"83.00"},200.77,"<1","N/A","http://www.selleck.cn/products/aurora-kinase-inhibitor-iii.html","C21H18F3N5O","Free Base","N/A","FC(F)(F)C1=CC(=CC=C1)NC2=CC=NC(=N2)NC3=CC(=CC=C3)NC(=O)C4CC4",5.032,3,3,7]
["S2933","AM580","e7","L6200-25","in 10mM DMSO","Retinoid Receptor","Metabolism","AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.",351.44,"102121-60-8",{"v":70,"d":"70.00"},199.18,"<1","N/A","http://www.selleck.cn/products/am580.html","C22H25NO3","Free Base","N/A","CC1(C)CCC(C)(C)C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(O)=O",4.673,2,1,3]
["S6540","NG 52","f7","L6200-25","in 10mM DMSO","CDK","Cell Cycle","NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively.",346.81,"212779-48-1",{"v":69,"d":"69.00"},198.96,"<1","N/A","http://www.selleck.cn/products/ng-52.html","C16H19ClN6O","Free Base","N/A","CC(C)[N]1C=NC2=C1N=C(NCCO)N=C2NC3=CC(=CC=C3)Cl",3.242,3,3,6]
["S6551","Adelmidrol","g7","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.",274.36,"1675-66-7",{"v":55,"d":"55.00"},200.47,{"v":55,"d":"55.00"},200.47,"http://www.selleck.cn/products/adelmidrol.html","C13H26N2O4","Free Base","N/A","OCCNC(=O)CCCCCCCC(=O)NCCO",-0.001,2,4,12]
["S6563","DMNQ","h7","L6200-25","in 10mM DMSO","Others","Others","DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.",218.21,"6956-96-3",{"v":44,"d":"44.00"},201.64,"<1","N/A","http://www.selleck.cn/products/dmnq.html","C12H10O4","Free Base","N/A","COC1=C(OC)C(=O)C2=C(C=CC=C2)C1=O",1.133,4,0,2]
["S6568","ML346","a8","L6200-25","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases.",272.26,"100872-83-1",{"v":27,"d":"27.00"},99.17,"<1","N/A","http://www.selleck.cn/products/ml346.html","C14H12N2O4","Free Base","N/A","COC1=CC=C(\\C=C\\C=C2C(=O)NC(=O)NC2=O)C=C1",1.315,4,2,3]
["S6596","AG-126","b8","L6200-25","in 10mM DMSO","ERK","MAPK","AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.",215.16,"118409-62-4",{"v":43,"d":"43.00"},199.85,"<1","N/A","http://www.selleck.cn/products/ag-126.html","C10H5N3O3","Free Base","N/A","OC1=CC(=CC=C1[N+]([O-])=O)C=C(C#N)C#N",1.668,0,1,2]
["S6616","ETC-159","c8","L6200-25","in 10mM DMSO","PORCN","Stem Cells & Wnt","ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.",391.38,"1638250-96-0",{"v":78,"d":"78.00"},199.29,"<1","N/A","http://www.selleck.cn/products/etc-159.html","C19H17N7O3","Free Base","ETC-1922159","CN1C(=O)N(C)C2=C([N](CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4)C=N2)C1=O",1.404,6,1,4]
["S6623","APY29","d8","L6200-25","in 10mM DMSO","IRE1","ER stress & UPR","APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM).",332.36,"1216665-49-4",{"v":32,"d":"32.00"},96.28,"<1","N/A","http://www.selleck.cn/products/apy29.html","C17H16N8","Free Base","N/A","C1CC1C2=CC(=N[NH]2)NC3=NC(=NC=C3)NC4=CC=C5N=C[NH]C5=C4",3.613,4,4,5]
["S6626","Brequinar (DUP785)","e8","L6200-25","in 10mM DMSO","Dehydrogenase","Metabolism","Brequinar (DUP785, NSC 368390) is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro.",375.37,"96187-53-0",{"v":37,"d":"37.00"},98.57,"<1","N/A","http://www.selleck.cn/products/brequinar.html","C23H15F2NO2","Free Base","NSC 368390","CC1=C(N=C2C=CC(=CC2=C1C(O)=O)F)C3=CC=C(C=C3)C4=C(F)C=CC=C4",6.008,2,0,3]
["S6631","Belotecan (CKD-602) hydrochloride","f8","L6200-25","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.",469.96,"213819-48-8",{"v":47,"d":"47.00"},100.01,{"v":4,"d":"4.00"},8.51,"http://www.selleck.cn/products/belotecan-ckd-602-hydrochloride.html","C25H28ClN3O4","Hydrochloride","N/A","Cl.CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=CC5=C4CCNC(C)C)C2=O",2.713,4,1,5]
["S6636","Azaindole 1 (TC-S 7001)","g8","L6200-25","in 10mM DMSO","ROCK","Cell Cycle","Azaindole 1 (TC-S 7001) is a selective Rho-associated protein kinase (ROCK) inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2 in an ATP-competitive manner.",402.79,"867017-68-3",{"v":81,"d":"81.00"},{"v":201.1,"d":"201.10"},"<1","N/A","http://www.selleck.cn/products/azaindole-1.html","C18H13ClF2N6O","Free Base","N/A","CC1=C[NH]C2=NC=CC(=C12)OC3=C(F)C=C(NC4=NC(=NC(=C4)Cl)N)C=C3F",4.587,4,3,4]
["S6648","PF-06282999","h8","L6200-25","in 10mM DMSO","Peroxidases","Metabolism","PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.",325.77,"1435467-37-0",{"v":65,"d":"65.00"},199.53,"<1","N/A","http://www.selleck.cn/products/pf-06282999.html","C13H12ClN3O3S","Free Base","N/A","COC1=C(C=C(Cl)C=C1)C2=CC(=O)NC(=S)N2CC(N)=O",1.868,3,2,4]
["S6714","INH14","a9","L6200-25","in 10mM DMSO","IκB/IKK,NF-κB","NF-κB","INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.",{"v":240.3,"d":"240.30"},"200134-22-1",{"v":48,"d":"48.00"},199.75,"<1","N/A","http://www.selleck.cn/products/inh14.html","C15H16N2O","Free Base","N/A","CCC1=CC=C(NC(=O)NC2=CC=CC=C2)C=C1",3.465,1,2,3]
["S6718","MKT-077","b9","L6200-25","in 10mM DMSO","Dyes","Others","MKT-077 (FJ-776) is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems.",{"v":432,"d":"432.00"},"147366-41-4",{"v":13,"d":"13.00"},30.09,{"v":86,"d":"86.00"},199.07,"http://www.selleck.cn/products/mkt-077.html","C21H22ClN3OS2","Free Base","FJ-776","[Cl-].CCN\\1C(=O)\\C(SC1=C\\C2=CC=CC=[N+]2CC)=C3/SC4=CC=CC=C4N3C",2.489,1,0,3]
["S6721","JG98","c9","L6200-25","in 10mM DMSO","Apoptosis related,HSP (HSP90)","Cytoskeletal Signaling","JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.",534.54,"1456551-16-8",{"v":8,"d":"8.00"},14.97,"<1","N/A","http://www.selleck.cn/products/jg98.html","C24H21Cl2N3OS3","Free Base","N/A","[Cl-].CCN1C(=O)C(\\S\\C1=C/C2=[N+](CC3=CC=CC=C3)C=CS2)=C4/SC5=C(C=CC(=C5)Cl)N4C",3.928,1,0,4]
["S6733","Edonerpic maleate","d9","L6200-25","in 10mM DMSO","Beta Amyloid","Neuronal Signaling","Edonerpic maleate (T-817) is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).",407.48,"519187-97-4",{"v":81,"d":"81.00"},198.78,{"v":81,"d":"81.00"},198.78,"http://www.selleck.cn/products/edonerpic-maleate.html","C20H25NO6S","Free Base","T-817 maleate","OC1CN(CCCOCCC2=CC3=C(SC=C3)C=C2)C1.OC(=O)\\C=C/C(O)=O",{"v":-0.67,"d":"-0.670"},3,1,9]
["S6734","PF-670462","e9","L6200-25","in 10mM DMSO","Casein Kinase","Metabolism","PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively.",410.32,"950912-80-8",{"v":82,"d":"82.00"},199.84,{"v":82,"d":"82.00"},199.84,"http://www.selleck.cn/products/pf-670462.html","C19H22Cl2FN5","Free Base","N/A","Cl.Cl.NC1=NC=CC(=N1)C2=C(N=C[N]2C3CCCCC3)C4=CC=C(F)C=C4",4.931,3,1,3]
["S6739","MN 64","f9","L6200-25","in 10mM DMSO","PARP","DNA Damage/DNA Repair","MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.",264.32,"92831-11-3",{"v":53,"d":"53.00"},200.51,"<1","N/A","http://www.selleck.cn/products/mn-64.html","C18H16O2","Free Base","N/A","CC(C)C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC=C3",{"v":4.33,"d":"4.330"},2,0,2]
["S6744","Inauhzin","g9","L6200-25","in 10mM DMSO","Sirtuin","Epigenetics","Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.",469.58,"309271-94-1",{"v":94,"d":"94.00"},200.18,"<1","N/A","http://www.selleck.cn/products/inauhzin.html","C25H19N5OS2","Free Base","N/A","CCC(SC1=NN=C2C(=N1)[NH]C3=C2C=CC=C3)C(=O)N4C5=C(SC6=CC=CC=C46)C=CC=C5",6.482,4,1,4]
["S6745","JW55","h9","L6200-25","in 10mM DMSO","PARP,Wnt/beta-catenin","Stem Cells & Wnt","JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).",434.49,"664993-53-7",{"v":87,"d":"87.00"},200.23,"<1","N/A","http://www.selleck.cn/products/jw55.html","C25H26N2O5","Free Base","N/A","COC1=CC=C(C=C1)C2(CCOCC2)CNC(=O)C3=CC=C(NC(=O)C4=CC=CO4)C=C3",2.926,5,2,7]
["S6747","SW-044248","a10","L6200-25","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.",421.52,"522650-83-5",{"v":14,"d":"14.00"},33.21,"<1","N/A","http://www.selleck.cn/products/sw-044248.html","C22H23N5O2S","Free Base","N/A","CCC(SC1=NC2=C(N=N1)C3=CC=CC=C3[N]2CC)C(=O)NC4=CC=CC=C4OC",{"v":4.95,"d":"4.950"},5,1,7]
["S6748","ML364","b10","L6200-25","in 10mM DMSO","DUB","Ubiquitin","ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.",517.54,"1991986-30-1",{"v":50,"d":"50.00"},96.61,"<1","N/A","http://www.selleck.cn/products/ml364.html","C24H18F3N3O3S2","Free Base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=CC=C2C(=O)NC3=NC(=CS3)C4=CC=CC=C4)C(F)(F)F",5.475,4,2,7]
["S6751","Brevianamide F","c10","L6200-25","in 10mM DMSO","Others","Others","Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..",283.33,"38136-70-8",{"v":57,"d":"57.00"},201.18,"<1","N/A","http://www.selleck.cn/products/brevianamide-f.html","C16H17N3O2","Free Base","N/A","O=C1NC(CC2=C[NH]C3=C2C=CC=C3)C(=O)N4CCCC14",1.255,2,2,2]
["S7716","Pimitespib (TAS-116)","d10","L6200-25","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).",454.53,"1260533-36-5",{"v":91,"d":"91.00"},200.21,"<1","N/A","http://www.selleck.cn/products/tas-116.html","C25H26N8O","Free Base","N/A","CCC1=C(C=CC(=C1)C(N)=O)[N]2N=C(C(C)C)C3=C(C=CN=C23)[N]4C=NC(=C4)C5=C[N](C)N=C5",3.927,5,1,6]
["S8828","Gboxin","e10","L6200-25","in 10mM DMSO","ATPase,OXPHOS","Apoptosis","Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. Gboxin inhibits the activity of F0F1 ATP synthase. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.",392.96,"2101315-36-8",{"v":39,"d":"39.00"},99.25,{"v":2,"d":"2.00"},5.09,"http://www.selleck.cn/products/gboxin.html","C22H33ClN2O2","Free Base","N/A","[Cl-].CCC1=[N+](C)C2=CC=CC=C2[N]1CC(=O)OC3CC(C)CCC3C(C)C",3.086,2,0,6]
["S8839","Borussertib","f10","L6200-25","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Borussertib is a covalent-allosteric inhibitor of protein kinase Akt with an IC50 of 0.8 nM and a Ki of 2.2 nM for WT Akt.",596.68,"1800070-77-2",{"v":100,"d":"100.00"},167.59,"<1","N/A","http://www.selleck.cn/products/borussertib.html","C36H32N6O3","Free Base","N/A","C=CC(=O)NC1=CC2=C(NC(=O)N2C3CCN(CC3)CC4=CC=C(C=C4)C5=NC6=C(C=C5C7=CC=CC=C7)C(=O)NC=C6)C=C1",4.051,4,3,7]
["S8843","AZD7648","g10","L6200-25","in 10mM DMSO","DNA-PK","DNA Damage/DNA Repair","AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases.",{"v":380.4,"d":"380.40"},"2230820-11-6",{"v":6,"d":"6.00"},15.77,"<1","N/A","http://www.selleck.cn/products/azd7648.html","C18H20N8O2","Free Base","N/A","CN1C(=O)N(C2CCOCC2)C3=NC(=NC=C13)NC4=C[N]5N=CN=C5C=C4C",1.059,6,1,3]
["S8847","Orludodstat (BAY 2402234)","h10","L6200-25","in 10mM DMSO","Dehydrogenase","Metabolism","Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.",520.84,"2225819-06-5",{"v":100,"d":"100.00"},{"v":192,"d":"192.00"},"<1","N/A","http://www.selleck.cn/products/bay-2402234.html","C21H18ClF5N4O4","Free Base","N/A","CCN1C(=NN(C1=O)C2=C(F)C=C(C(=O)NC3=C(F)C=CC=C3Cl)C(=C2)OC(C)C(F)(F)F)CO",4.103,4,2,8]
["S9015","Homoharringtonine (CGX-635)","a11","L6200-25","in 10mM DMSO","STAT","JAK/STAT","Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.",545.62,"26833-87-4",{"v":10,"d":"10.00"},18.33,"N/A","N/A","https://www.selleckchem.com/products/homoharringtonine.html","C29H39NO9","free Base","Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633","COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC",2.418,7,0,11]
["S9024","3-O-Acetyl-11-keto-β-boswellic acid (AKBA)","b11","L6200-25","in 10mM DMSO","Lipoxygenase","Metabolism","3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.",512.72,"67416-61-9",{"v":100,"d":"100.00"},195.04,"N/A","N/A","https://www.selleckchem.com/products/akba.html","C32H48O5","Salt","FA42758","CC1CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(C)=O)C(C)(C5CCC34C)C(O)=O)C2C1C",6.081,4,0,3]
["S9050","Boldine","c11","L6200-25","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.",327.37,"476-70-0",{"v":10,"d":"10.00"},30.55,"N/A","N/A","https://www.selleckchem.com/products/boldine.html","C19H21NO4","free base","1, 10-Dimethoxy-2, 9-dihydroxyaporphine; ex Peumus boldus","COC1=C(O)C=C2CC3N(C)CCC4=CC(=C(OC)C(=C34)C2=C1)O",3.083,2,2,2]
["S9053","Irisflorentin","d11","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine.",386.35,"41743-73-1",{"v":10,"d":"10.00"},25.88,"N/A","N/A","https://www.selleckchem.com/products/irisflorentin.html","C20H18O8","free base","FI73921","COC1=CC(=CC(=C1OC)OC)C2=COC3=CC4=C(OCO4)C(=C3C2=O)OC",2.569,8,0,5]
["S9102","Magnolin","e11","L6200-25","in 10mM DMSO","ERK","MAPK","Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).",416.46,"31008-18-1",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","https://www.selleckchem.com/products/magnolin.html","C23H28O7","free Base","N/A","COC1=C(OC)C=C(C=C1)C2OCC3C2COC3C4=CC(=C(OC)C(=C4)OC)OC",2.618,7,0,7]
["S9110","Morin","f11","L6200-25","in 10mM DMSO","Others","Others","Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.",302.24,"480-16-0",{"v":10,"d":"10.00"},33.09,"N/A","N/A","https://www.selleckchem.com/products/morin.html","C15H10O7","free base","Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum","OC1=CC(=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O)O",{"v":1.63,"d":"1.630"},2,5,1]
["S9111","Isorhamnetin","g11","L6200-25","in 10mM DMSO","Tyrosinase","Proteases","Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.",316.26,"480-19-3",{"v":63,"d":"63.00"},{"v":199.2,"d":"199.20"},"N/A","N/A","https://www.selleckchem.com/products/isorhamnetin.html","C16H12O7","free base","3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol","COC1=C(O)C=CC(=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",1.856,3,4,2]
["S9123","Eriodictyol","h11","L6200-25","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.",288.25,"552-58-9",{"v":57,"d":"57.00"},197.74,"N/A","N/A","https://www.selleckchem.com/products/eriodictyol.html","C15H12O6","free base","N/A","OC1=CC2=C(C(=O)CC(O2)C3=CC(=C(O)C=C3)O)C(=C1)O",2.131,2,4,1]
["S9171","Harpagoside","a2","L6200-26","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects.",494.49,"19210-12-9",{"v":99,"d":"99.00"},200.21,"N/A","N/A","https://www.selleckchem.com/products/harpagoside.html","C24H30O11","free base","N/A","CC1(CC(O)C2(O)C=COC(OC3OC(CO)C(O)C(O)C3O)C12)OC(=O)\\C=C\\C4=CC=CC=C4",{"v":-1.39,"d":"-1.390"},5,5,7]
["S9192","Vitexin","b2","L6200-26","in 10mM DMSO","Others","Others","Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.",432.38,"3681-93-4",{"v":47,"d":"47.00"},{"v":108.7,"d":"108.70"},"N/A","N/A","https://www.selleckchem.com/products/vitexin.html","C21H20O10","free base","Apigenin-8-C-glucoside","OCC1OC(C(O)C(O)C1O)C2=C(O)C=C(O)C3=C2OC(=CC3=O)C4=CC=C(O)C=C4",0.018,3,7,3]
["S9248","Homoorientin","c2","L6200-26","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent.",448.38,"4261-42-1",{"v":90,"d":"90.00"},200.72,"N/A","N/A","https://www.selleckchem.com/products/homoorientin.html","C21H20O11","free Base","Isoorientin, Luteolin-6-C-glucoside","OCC1OC(C(O)C(O)C1O)C2=C(O)C3=C(OC(=CC3=O)C4=CC(=C(O)C=C4)O)C=C2O",-0.224,3,8,3]
["S9285","Fargesin","d2","L6200-26","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.",{"v":370.4,"d":"370.40"},"31008-19-2",{"v":36,"d":"36.00"},97.19,"N/A","N/A","https://www.selleckchem.com/products/fargesin.html","C21H22O6","free base","N/A","COC1=CC=C(C=C1OC)C2OCC3C2COC3C4=CC5=C(OCO5)C=C4",2.436,6,0,4]
["S9288","Casticin","e2","L6200-26","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.",374.34,"479-91-4",{"v":75,"d":"75.00"},200.35,"N/A","N/A","https://www.selleckchem.com/products/casticin.html","C19H18O8","free base","Vitexicarpin","COC1=C(O)C=C(C=C1)C2=C(OC)C(=O)C3=C(O2)C=C(OC)C(=C3O)OC",2.291,6,2,5]
["S9416","Triptonide","f2","L6200-26","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.",358.39,"38647-11-9",{"v":71,"d":"71.00"},198.11,"N/A","N/A","https://www.selleckchem.com/products/triptonide.html","C20H22O6","free base","N/A","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2=O",1.259,6,0,1]
["S9159","momordin-Ic","g2","L6200-26","in 10mM DMSO","SUMO","Ubiquitin","Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.",764.94,"96990-18-0",{"v":100,"d":"100.00"},130.73,"N/A","N/A","https://www.selleckchem.com/products/momordin-ic.html","C41H64O13","free base","N/A","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(O)C(OC7OCC(O)C(O)C7O)C6O)C(O)=O)C(C)(C)C5CCC34C)C2C1)C(O)=O",3.591,6,5,6]
["S1058","BI-1347","h2","L6200-26","in 10mM DMSO","CDK","Cell Cycle","BI-1347 is a small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM.",356.42,"2163056-91-3",{"v":71,"d":"71.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://www.selleck.cn/products/bi-1347.html","C22H20N4O","Free Base","N/A","CN(C)C(=O)C[N]1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC4=CC=CC=C34",{"v":2.54,"d":"2.540"},3,0,4]
["S1073","BML-210 (CAY10433)","a3","L6200-26","in 10mM DMSO","HDAC","Epigenetics","BML-210 (CAY10433) is a small molecule inhibitor of HDAC.BML-210 inhibits the HDAC4-VP16-driven reporter signal in a dose-dependent manner with an apparent IC50 of ∼5 µM.",339.43,"537034-17-6",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://www.selleck.cn/products/bml210-cay10433.html","C20H25N3O2","Free Base","N/A","NC1=CC=CC=C1NC(=O)CCCCCCC(=O)NC2=CC=CC=C2",3.028,2,3,9]
["S2009","Indirubin-3'-monoxime","b3","L6200-26","in 10mM DMSO","CDK","Cell Cycle","Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.",277.28,"160807-49-8",{"v":55,"d":"55.00"},198.36,"<1","N/A","http://www.selleck.cn/products/indirubin-3-monoxime.html","C16H11N3O2","Free Base","Indirubin-3'-oxime","O/N=C1/C(NC2=C1C=CC=C2)=C3\\C(=O)NC4=C3C=CC=C4",1.943,2,2,0]
["S2132","SR-4370","c3","L6200-26","in 10mM DMSO","HDAC","Epigenetics","SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth.",304.33,"1816294-67-3",{"v":61,"d":"61.00"},200.44,"<1","N/A","http://www.selleck.cn/products/sr4370.html","C17H18F2N2O","Free Base","N/A","CCCCNNC(=O)C1=CC=C(C=C1)C2=C(F)C(=CC=C2)F",3.804,1,2,6]
["S2249","PF 4800567","d3","L6200-26","in 10mM DMSO","Casein Kinase","Stem Cells & Wnt","PF 4800567 is a novel and potent inhibitor of casein kinase 1 epsilon (IC50=32 nM) with greater than 20-fold selectivity over casein kinase 1 delta(IC50=711 nM).",359.81,"1188296-52-7",{"v":72,"d":"72.00"},200.11,"<1","N/A","http://www.selleck.cn/products/pf-4800567.html","C17H18ClN5O2","Free Base","N/A","NC1=NC=NC2=C1C(=N[N]2C3CCOCC3)COC4=CC=CC(=C4)Cl",{"v":2.18,"d":"2.180"},5,1,4]
["S2272","Indoprofen","e3","L6200-26","in 10mM DMSO","COX,Others,PDPK1","PI3K/Akt/mTOR","Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein.",281.31,"31842-01-0",{"v":52,"d":"52.00"},184.85,"<1","N/A","http://www.selleck.cn/products/indoprofen.html","C17H15NO3","Free Base","N/A","CC(C(O)=O)C1=CC=C(C=C1)N2CC3=C(C=CC=C3)C2=O",2.701,2,0,3]
["S2419","Eprobemide","f3","L6200-26","in 10mM DMSO","MAO","Metabolism","Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.",282.77,"87940-60-1",{"v":57,"d":"57.00"},201.58,"<1","N/A","http://www.selleck.cn/products/eprobemide.html","C14H19ClN2O2","Free Base","Befol, LIS 630","ClC1=CC=C(C=C1)C(=O)NCCCN2CCOCC2",1.591,2,1,5]
["S2444","Parbendazole","g3","L6200-26","in 10mM DMSO","Microtubule Associated","Cytoskeletal Signaling","Parbendazole (SKF 29044) is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.",247.29,"14255-87-9",{"v":3,"d":"3.00"},12.13,"<1","N/A","http://www.selleck.cn/products/parbendazole.html","C13H17N3O2","Free Base","SKF 29044","CCCCC1=CC=C2N=C(NC(=O)OC)[NH]C2=C1",3.505,3,2,5]
["S2935","Nicotinamide Riboside Chloride","h3","L6200-26","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.",{"v":290.7,"d":"290.70"},"23111-00-4",{"v":58,"d":"58.00"},199.52,{"v":58,"d":"58.00"},199.52,"http://www.selleck.cn/products/nicotinamide-riboside-chloride.html","C11H15ClN2O5","Chloride","N/A","[Cl-].NC(=O)C1=CC=C[N+](=C1)C2OC(CO)C(O)C2O",-3.882,2,4,3]
["S6548","NKL 22","a4","L6200-26","in 10mM DMSO","HDAC","Epigenetics","NKL 22 is a selective inhibitor of HDAC with IC50 of 78 µM.",{"v":325.4,"d":"325.40"},"537034-15-4",{"v":65,"d":"65.00"},199.75,"<1","N/A","http://www.selleck.cn/products/nkl-22.html","C19H23N3O2","Free Base","N/A","NC1=CC=CC=C1NC(=O)CCCCCC(=O)NC2=CC=CC=C2",2.572,2,3,8]
["S6647","Bardoxolone","b4","L6200-26","in 10mM DMSO","Nrf2","Immunology & Inflammation","Bardoxolone (CDDO, RTA 401), acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2  that induce programmed cell death (apoptosis) in cancer cells.",491.66,"218600-44-3",{"v":6,"d":"6.00"},{"v":12.2,"d":"12.20"},"<1","N/A","http://www.selleck.cn/products/bardoxolone.html","C31H41NO4","Free Base","CDDO, RTA 401","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C5(C)C=C(C#N)C(=O)C(C)(C)C5CCC34C)C(O)=O",5.573,3,0,1]
["S6650","EN6","c4","L6200-26","in 10mM DMSO","Autophagy","Autophagy","EN6 is a novel covalent autophagy activator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein.",368.34,"1808714-73-9",{"v":74,"d":"74.00"},{"v":200.9,"d":"200.90"},"<1","N/A","http://www.selleck.cn/products/en6.html","C19H14F2N4O2","Free Base","N/A","FC1=C(NC(=O)C=C)C=C(NC(=O)C2=C[N](N=C2)C3=CC=CC=C3F)C=C1",{"v":3.07,"d":"3.070"},3,2,5]
["S6656","VAS2870","d4","L6200-26","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","VAS2870 is a pan-NADPH oxidase (NOX) inhibitor.",360.39,"722456-31-7",{"v":36,"d":"36.00"},99.89,"<1","N/A","http://www.selleck.cn/products/vas2870.html","C18H12N6OS","Free Base","N/A","C([N]1N=NC2=C1N=CN=C2SC3=NC4=C(O3)C=CC=C4)C5=CC=CC=C5",4.369,6,0,4]
["S6673","CCG-222740","e4","L6200-26","in 10mM DMSO","Actin,Rho","Cell Cycle","CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.",444.86,"1922098-69-8",{"v":89,"d":"89.00"},200.06,"<1","N/A","http://www.selleck.cn/products/ccg-222740.html","C23H19ClF2N2O3","Free Base","N/A","FC1(F)CC(CN(C1)C(=O)C2=CC(=CC=C2)C3=CC=CO3)C(=O)NC4=CC=C(Cl)C=C4",{"v":3.99,"d":"3.990"},3,1,4]
["S6680","L-779450","f4","L6200-26","in 10mM DMSO","Raf","MAPK","L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM.",{"v":347.8,"d":"347.80"},"303727-31-3",{"v":70,"d":"70.00"},201.27,"<1","N/A","http://www.selleck.cn/products/l-779450.html","C20H14ClN3O","Free Base","L-779,450","OC1=CC(=CC=C1Cl)C2=C(N=C([NH]2)C3=CC=CC=C3)C4=CC=NC=C4",{"v":4.67,"d":"4.670"},2,2,3]
["S8500","BAY1125976","g4","L6200-26","in 10mM DMSO","Akt","PI3K/Akt/mTOR","BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).",383.45,"1402608-02-9",{"v":11,"d":"11.00"},28.69,"<1","N/A","http://www.selleck.cn/products/bay1125976.html","C23H21N5O","Free Base","N/A","NC(=O)C1=N[N]2C(=NC(=C2C3=CC=CC=C3)C4=CC=C(C=C4)C5(N)CCC5)C=C1",3.335,3,2,4]
["S8904","USP25/28 inhibitor AZ1","h4","L6200-26","in 10mM DMSO","DUB","Ubiquitin","AZ1 is a  potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.",422.21,"2165322-94-9",{"v":84,"d":"84.00"},198.95,"<1","N/A","http://www.selleck.cn/products/usp25-28-inhibitor-az1.html","C17H16BrF4NO2","Free Base","N/A","OCCNCC1=C(OCC2=CC(=C(F)C=C2)C(F)(F)F)C=CC(=C1)Br",4.291,1,2,8]
["S8909","UBCS039","a5","L6200-26","in 10mM DMSO","Sirtuin","Epigenetics","UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.",247.29,"358721-70-7",{"v":49,"d":"49.00"},198.15,"<1","N/A","http://www.selleck.cn/products/ubcs039.html","C16H13N3","Free Base","N/A","N1C(C2=CN=CC=C2)C3=CC=C[N]3C4=CC=CC=C14",2.914,1,1,1]
["S9044","Ginsenoside F2","b5","L6200-26","in 10mM DMSO","Others","Others","Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.",785.01,"62025-49-4",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleck.cn/products/ginsenoside-f2.html","C42H72O13","Free Base","N/A","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6O)C(C)(C)C5CCC34C",2.295,4,9,10]
["S9096","ligustroflavone","c5","L6200-26","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","Ligustroflavone (Nuezhenoside), isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.",724.66,"260413-62-5",{"v":100,"d":"100.00"},{"v":138,"d":"138.00"},{"v":100,"d":"100.00"},{"v":138,"d":"138.00"},"http://www.selleck.cn/products/ligustroflavone.html","C33H40O18","Free Base","Nuezhenoside","CC1OC(OCC2OC(OC3=CC(=C4C(=O)C=C(OC4=C3)C5=CC=C(O)C=C5)O)C(OC6OC(C)C(O)C(O)C6O)C(O)C2O)C(O)C(O)C1O",-1.237,8,10,8]
["S9116","Chikusetsusaponin IVa","d5","L6200-26","in 10mM DMSO","AMPK,Immunology & Inflammation related","Immunology & Inflammation","Chikusetsusaponin IVa (Calenduloside F), a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity. Chikusetsusaponin IVa is a novel AMPK activator.",794.97,"51415-02-2",{"v":100,"d":"100.00"},125.79,{"v":100,"d":"100.00"},125.79,"http://www.selleck.cn/products/chikusetsusaponin-iva.html","C42H66O14","Free Base","Calenduloside F","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(O)C(O)C6O)C(O)=O)C(C)(C)C5CCC34C)C2C1)C(=O)OC7OC(CO)C(O)C(O)C7O",2.898,6,7,7]
["S9117","(20S)Ginsenoside Rg2","e5","L6200-26","in 10mM DMSO","Others","Others","(20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells.",785.01,"52286-74-5",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://www.selleck.cn/products/20s-ginsenoside-rg2.html","C42H72O13","Free Base","N/A","CC1OC(OC2C(O)C(O)C(CO)OC2OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(O)CCC=C(C)C)C6(C)CCC(O)C(C)(C)C36)C(O)C(O)C1O",2.014,4,8,9]
["S9131","Punicalagin","f5","L6200-26","in 10mM DMSO","Anti-infection,Immunology & Inflammation related","Immunology & Inflammation","Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects., Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.",1084.72,"65995-63-3",{"v":100,"d":"100.00"},92.19,{"v":100,"d":"100.00"},92.19,"http://www.selleck.cn/products/punicalagin.html","C48H28O30","Free Base","N/A","OC1COC(=O)C2=CC(=C(O)C(=C2C3=C4C(=O)OC5=C(O)C(=C(C6=C5C4=C(OC6=O)C(=C3O)O)C7=C(C=C(O)C(=C7O)O)C(=O)OC1C8OC(=O)C9=CC(=C(O)C(=C9C%10=C(C=C(O)C(=C%10O)O)C(=O)OC8C=O)O)O)O)O)O",3.128,13,17,2]
["S9235","Didymin","g5","L6200-26","in 10mM DMSO","p53","Apoptosis","Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.",594.56,"14259-47-3",{"v":100,"d":"100.00"},168.19,{"v":100,"d":"100.00"},168.19,"http://www.selleck.cn/products/didymin.html","C28H34O14","Free Base","Neoponcirin, Isosakuranetin-7-O-rutinoside","COC1=CC=C(C=C1)C2CC(=O)C3=C(O2)C=C(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)C=C3O",-0.189,7,7,7]
["S0102","L 189","h5","L6200-26","in 10mM DMSO","CRISPR/Cas9,DNA/RNA Synthesis","DNA Damage/DNA Repair","L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L 189 specifically sensitizes cancer cells to DNA damage.",246.29,"64232-83-3",{"v":49,"d":"49.00"},198.95,"˂1","N/A","http://www.selleckchem.com/products/l-189.html","C11H10N4OS","Free Base","N/A","NC1=C(N=CC2=CC=CC=C2)C(=O)NC(=S)N1",1.163,2,3,2]
["S0160","Toloxatone (MD69276)","a6","L6200-26","in 10mM DMSO","MAO","Metabolism","Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of  0.93 µM. Toloxatone is an antidepressant agent.",207.23,"29218-27-7",{"v":41,"d":"41.00"},197.85,"˂1","N/A","http://www.selleckchem.com/products/md69276.html","C11H13NO3","Free Base","Humoryl, Perenum, Umoril","CC1=CC=CC(=C1)N2CC(CO)OC2=O",1.593,2,1,2]
["S0443","Desciclovir","b6","L6200-26","in 10mM DMSO","Anti-infection","Microbiology","Desciclovir (DCV, 6-Deoxyacyclovir, BW A515U) is a prodrug of the antiherpetic agent acyclovir (ACV) that converted into ACV by xanthine oxidase in humans.",209.21,"84408-37-7",{"v":42,"d":"42.00"},200.76,{"v":25,"d":"25.00"},{"v":119.5,"d":"119.50"},"http://www.selleckchem.com/products/desciclovir.html","C8H11N5O2","Free Base","DCV, 6-Deoxyacyclovir, BW A515U","NC1=NC2=C(C=N1)N=C[N]2COCCO",-0.942,4,2,4]
["S0469","ML216","c6","L6200-26","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","ML216 (CID-49852229) is a potent and selective inhibitor of the DNA unwinding activity of BLM(Bloom’s syndrome protein) with antitumor activity. ML216 inhibits helicases with IC50 of 0.97 μM and 2.98 μM for BLM636-1298 and BLMfull-length, respectively.",383.32,"1430213-30-1",{"v":38,"d":"38.00"},99.13,"˂1","N/A","http://www.selleckchem.com/products/ml216.html","C15H9F4N5OS","Free Base","CID-49852229","FC1=CC=C(NC(=O)NC2=NN=C(S2)C3=CC=NC=C3)C=C1C(F)(F)F",2.919,4,2,4]
["S0500","Purvalanol B","d6","L6200-26","in 10mM DMSO","CDK","Cell Cycle","Purvalanol B (NG-95) is a potent and selective inhibitor of cyclin-dependent kinase (CDK) with IC50 of 6 nM, 6 nM, 9 nM and 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively.",{"v":432.9,"d":"432.90"},"212844-54-7",{"v":86,"d":"86.00"},198.66,"˂1","N/A","http://www.selleckchem.com/products/purvalanol-b-ng-95.html","C20H25ClN6O3","Free Base","NG 95","CC(C)C(CO)NC1=NC2=C(N=C[N]2C(C)C)C(=N1)NC3=CC=C(C(O)=O)C(=C3)Cl",4.092,4,3,8]
["S0788","ML 210","e6","L6200-26","in 10mM DMSO","Ferroptosis,Peroxidases","Metabolism","ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.",475.32,"1360705-96-9",{"v":15,"d":"15.00"},31.56,"<1","N/A","http://www.selleckchem.com/products/ml210.html","C22H20Cl2N4O4","Free Base","CID 49766530","CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)[N+]([O-])=O",4.648,3,0,5]
["S2121","Licofelone (ML3000)","f6","L6200-26","in 10mM DMSO","COX","Neuronal Signaling","Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.",379.88,"156897-06-2",{"v":19,"d":"19.00"},50.02,"<1","N/A","http://www.selleckchem.com/products/licofelone.html","C23H22ClNO2","Free Base","ML3000","CC1(C)C[N]2C(=C(C3=CC=C(Cl)C=C3)C(=C2C1)C4=CC=CC=C4)CC(O)=O",{"v":5.78,"d":"5.780"},1,0,4]
["S2288","Rubitecan","g6","L6200-26","in 10mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.",393.35,"91421-42-0",{"v":58,"d":"58.00"},147.45,"<1","N/A","http://www.selleckchem.com/products/rubitecan.html","C20H15N3O6","Free Base","9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=C(C5=C4)[N+]([O-])=O)C2=O",{"v":1.64,"d":"1.640"},4,0,2]
["S2427","Triglycidyl Isocyanurate (Teroxirone)","h6","L6200-26","in 10mM DMSO","DNA/RNA Synthesis,p53","Apoptosis","Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.",297.26,"2451-62-9",{"v":59,"d":"59.00"},198.48,"<1","N/A","http://www.selleckchem.com/products/triglycidyl-isocyanurat.html","C12H15N3O6","Free Base","Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC","O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4",-0.894,6,0,6]
["S2447","Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)","a7","L6200-26","in 10mM DMSO","ADC Cytotoxin,Microtubule Associated","Cytoskeletal Signaling","Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.",635.14,"66584-72-3",{"v":100,"d":"100.00"},157.45,"<1","N/A","http://www.selleckchem.com/products/ansamitocin-p-3-maytansinol-isobutyrate.html","C32H43ClN2O9","Free Base","Antibiotic C 15003P3","COC1\\C=C\\C=C(C)\\CC2=CC(=C(Cl)C(=C2)OC)N(C)C(=O)CC(OC(=O)C(C)C)C3(C)OC3C(C)C4CC1(O)NC(=O)O4",4.445,8,1,5]
["S2595","FK-3311","b7","L6200-26","in 10mM DMSO","COX","Immunology & Inflammation","FK-3311 (COX-2 Inhibitor V) is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.",341.33,"116686-15-8",{"v":68,"d":"68.00"},199.22,"<1","N/A","http://www.selleckchem.com/products/fk-3311.html","C15H13F2NO4S","Free Base","COX-2 Inhibitor V","CC(=O)C1=CC=C(N[S](C)(=O)=O)C(=C1)OC2=CC=C(F)C=C2F",2.452,4,1,5]
["S4922","NSC 632839","c7","L6200-26","in 10mM DMSO","DUB,SUMO","Ubiquitin","NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.",339.86,"157654-67-6",{"v":7,"d":"7.00"},{"v":20.6,"d":"20.60"},"<1","N/A","http://www.selleckchem.com/products/nsc-632839.html","C21H21NO.HCl","Free Base","N/A","Cl.CC1=CC=C(C=C1)\\C=C2/CNC\\C(=C/C3=CC=C(C)C=C3)C2=O",4.726,1,1,2]
["S5183","PD 169316","d7","L6200-26","in 10mM DMSO","Enterovirus,p38 MAPK,TGF-beta/Smad","MAPK","PD 169316 is a potent, selective and cell-permeable p38 MAP kinase inhibitor with IC50 of 89 nM. PD169316 abrogates signaling initiated by both TGFbeta and Activin A. PD169316 shows antiviral activity against Enterovirus71.",360.34,"152121-53-4",{"v":14,"d":"14.00"},38.85,"<1","N/A","http://www.selleckchem.com/products/pd-169316.html","C20H13FN4O2","Free Base","N/A","[O-][N+](=O)C1=CC=C(C=C1)C2=NC(=C([NH]2)C3=CC=NC=C3)C4=CC=C(F)C=C4",4.348,2,1,4]
["S6615","ATB 346","e7","L6200-26","in 10mM DMSO","Apoptosis related,COX,Others","Immunology & Inflammation","ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.",365.45,"1226895-20-0",{"v":73,"d":"73.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/atb-346.html","C21H19NO3S","Free Base","N/A","COC1=CC2=CC=C(C=C2C=C1)C(C)C(=O)OC3=CC=C(C=C3)C(N)=S",4.521,3,1,6]
["S6685","Mavacoxib","f7","L6200-26","in 10mM DMSO","COX","Immunology & Inflammation","Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).",385.34,"170569-88-7",{"v":77,"d":"77.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/mavacoxib.html","C16H11F4N3O2S","Free Base","Trocoxil","N[S](=O)(=O)C1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(F)C=C3)C(F)(F)F",4.147,3,1,4]
["S6686","SC-560","g7","L6200-26","in 10mM DMSO","COX","Immunology & Inflammation","SC-560 is a highly selective COX-1 inhibitor with IC50 of 9 nM, compared with the IC50 of 6.3 μM for COX-2, nearly 1,000-fold higher than with COX-1.",352.74,"188817-13-2",{"v":70,"d":"70.00"},198.45,"<1","N/A","http://www.selleckchem.com/products/sc-560.html","C17H12ClF3N2O","Free Base","N/A","COC1=CC=C(C=C1)[N]2N=C(C=C2C3=CC=C(Cl)C=C3)C(F)(F)F",5.885,2,0,4]
["S6780","TFAP","h7","L6200-26","in 10mM DMSO","COX","Immunology & Inflammation","TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective and cell-permeable cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.",281.23,"1011244-68-0",{"v":56,"d":"56.00"},199.13,"<1","N/A","http://www.selleckchem.com/products/tfap.html","C13H10F3N3O","Free Base","N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide","NC1=CN=C(NC(=O)C2=CC=C(C=C2)C(F)(F)F)C=C1",2.198,2,2,3]
["S6781","Brassinazole","a8","L6200-26","in 10mM DMSO","Others","Endocrinology & Hormones","Brassinazole (BRZ) is a potent inhibitor of brassinosteroid (BR) biosynthesis with IC50 of ~ 1 μM, that has been developed to probe the myriad functions of brassinosteroids. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division.",327.81,"224047-41-0",{"v":66,"d":"66.00"},201.34,"<1","N/A","http://www.selleckchem.com/products/brassinazole.html","C18H18ClN3O","Free Base","BRZ","CC(O)(C(CC1=CC=C(Cl)C=C1)[N]2C=NC=N2)C3=CC=CC=C3",3.671,2,0,5]
["S6784","STAT5-IN-1","b8","L6200-26","in 10mM DMSO","STAT","JAK/STAT","STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.",293.28,"285986-31-4",{"v":20,"d":"20.00"},68.19,"<1","N/A","http://www.selleckchem.com/products/stat-in-1.html","C16H11N3O3","Free Base","N/A","O=C(N\\N=C\\C1=COC2=C(C=CC=C2)C1=O)C3=CC=CN=C3",0.943,5,1,3]
["S6786","ERK5-IN-2","c8","L6200-26","in 10mM DMSO","ERK","MAPK","ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50 of 0.82 μM and 3 μM for ERK5 and ERK5 MEF2D, respectively.",388.19,"1888305-96-1",{"v":78,"d":"78.00"},200.93,"<1","N/A","http://www.selleckchem.com/products/erk5-in-2.html","C17H11BrFN3O2","Free Base","N/A","FC1=C(C(=CC=C1)Br)C(=O)C2=C[NH]C(=C2)C(=O)NC3=CN=CC=C3",3.207,3,2,4]
["S6790","Ellipticine hydrochloride","d8","L6200-26","in 10mM DMSO","Others,P450 (e.g. CYP17),Topoisomerase","Metabolism","Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.",282.77,"5081-48-1",{"v":3,"d":"3.00"},10.61,"˂1","N/A","http://www.selleckchem.com/products/ellipticine-hydrochloride.html","C17H15ClN2","Hydrochloride","NSC 71795 hydrochloride, PZE","Cl.CC1=C2C=CN=CC2=C(C)C3=C1[NH]C4=CC=CC=C34",4.435,1,1,0]
["S6796","BTB-1","e8","L6200-26","in 10mM DMSO","Kinesin","Cytoskeletal Signaling","BTB-1 is a novel, selective and reversible inhibitor of the mitotic motor protein Kif18A with IC50 of 1.69 μM.",297.71,"86030-08-2",{"v":60,"d":"60.00"},201.54,"<1","N/A","http://www.selleckchem.com/products/btb-1.html","C12H8ClNO4S","Free Base","N/A","[O-][N+](=O)C1=C(C=CC(=C1)Cl)[S](=O)(=O)C2=CC=CC=C2",3.491,2,0,3]
["S6804","CX546","f8","L6200-26","in 10mM DMSO","GluR","Neuronal Signaling","CX546, a prototypical ampakine agent, is a selective positive AMPA receptor modulator.",247.29,"215923-54-9",{"v":49,"d":"49.00"},198.15,"<1","N/A","http://www.selleckchem.com/products/cx546.html","C14H17NO3","Free Base","N/A","O=C(N1CCCCC1)C2=CC=C3OCCOC3=C2",1.947,3,0,1]
["S6814","GS-441524","g8","L6200-26","in 10mM DMSO","Antiviral","Microbiology","GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM.",291.26,"1191237-69-0",{"v":58,"d":"58.00"},199.13,"<1","N/A","http://www.selleckchem.com/products/gs-441524.html","C12H13N5O4","Free Base","N/A","NC1=NC=N[N]2C1=CC=C2C3(OC(CO)C(O)C3O)C#N",{"v":-1.43,"d":"-1.430"},3,4,2]
["S6822","TMB dihydrochloride","h8","L6200-26","in 10mM DMSO","Dyes,Peroxidases","Others","TMB dihydrochloride (3,3',5,5'-Tetramethylbenzidine dihydrochloride hydrate, TMB-d, BM blue, Sure Blue TMB) is an excellent colorimetric substrate for detection of horseradish peroxidase (HRP) labeled probes and is used in staining procedures in immunohistochemistry and in enzyme-linked immunosorbent assays (ELISA).",313.27,"64285-73-0",{"v":6,"d":"6.00"},19.15,{"v":2,"d":"2.00"},6.38,"http://www.selleckchem.com/products/tmb-dihydrochloride.html","C16H22Cl2N2","Dihydrochloride","3,3',5,5'-Tetramethylbenzidine dihydrochloride hydrate, TMB-d, BM blue dihydrochloride, Sure Blue TMB dihydrochloride","Cl.Cl.CC1=C(N)C(=CC(=C1)C2=CC(=C(N)C(=C2)C)C)C",4.564,0,2,1]
["S6836","TH-257","a9","L6200-26","in 10mM DMSO","LIM kinase","Cell Cycle","TH-257 is a potent and exquisitely selective LIM kinase (LIMK) inhibitor with IC50 of 84 nM and 39 nM for LIMK1 and LIMK2, respectively.",422.54,"2244678-29-1",{"v":84,"d":"84.00"},{"v":198.8,"d":"198.80"},"˂1","N/A","http://www.selleckchem.com/products/th-257.html","C24H26N2O3S","Free Base","N/A","CCCCN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)[S](=O)(=O)NC3=CC=CC=C3",4.643,3,1,9]
["S6837","R-10015","b9","L6200-26","in 10mM DMSO","LIM kinase","Cell Cycle","R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. R-10015 binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection.",410.86,"2097938-51-5",{"v":82,"d":"82.00"},199.58,"˂1","N/A","http://www.selleckchem.com/products/r-10015.html","C20H19ClN6O2","Free Base","N/A","COC(=O)C1=CC=C2N=C([NH]C2=C1)C3CCN(CC3)C4=NC=NC5=C4C(=C[NH]5)Cl",3.677,5,2,4]
["S7969","THZ2","c9","L6200-26","in 10mM DMSO","CDK","Cell Cycle","THZ2, a THZ1 analog, is a selective inhibitor of CDK7 with IC50 of 13.9 nM. THZ2 efficiently suppresses the clonogenic growth of TNBC cells with IC50 of ~10 nM.",566.05,"1604810-84-5",{"v":100,"d":"100.00"},176.66,"˂1","N/A","http://www.selleckchem.com/products/thz2.html","C31H28ClN7O2","Free Base","N/A","CN(C)C\\C=C\\C(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=CC=CC=C45",5.619,4,4,9]
["S8784","PQR620","d9","L6200-26","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.",445.47,"1927857-56-4",{"v":20,"d":"20.00"},{"v":44.9,"d":"44.90"},"˂1","N/A","http://www.selleckchem.com/products/pqr620.html","C21H25F2N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3C4CCC3COC4)N5C6CCC5COC6)C(=C1)C(F)F",2.434,6,1,4]
["S8876","RK-287107","e9","L6200-26","in 10mM DMSO","PARP","DNA Damage/DNA Repair","RK-287107 is a novel, potent and selective tankyrase inhibitor with antitumor activity. RK-287107 inhibits tankyrase-1 and tankyrase-2 in vitro with IC50 of 14.3 nM and 10.6 nM.",416.46,"2171386-10-8",{"v":83,"d":"83.00"},{"v":199.3,"d":"199.30"},"˂1","N/A","http://www.selleckchem.com/products/pk-287107.html","C22H26F2N4O2","Free Base","N/A","OCCN1CC2(CCN(CC2)C3=NC4=C(CCCC4)C(=O)N3)C5=C1C=C(F)C=C5F",2.731,2,2,3]
["S8894","SR-4835","f9","L6200-26","in 10mM DMSO","CDK","Cell Cycle","SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.",499.36,"2387704-62-1",{"v":100,"d":"100.00"},200.26,"<1","N/A","http://www.selleckchem.com/products/sr-4835.html","C21H20Cl2N10O","Free Base","N/A","C[N]1C=C(C=N1)[N]2C=NC3=C2N=C(N=C3NCC4=NC5=C([NH]4)C=C(Cl)C(=C5)Cl)N6CCOCC6",3.538,6,2,5]
["S8903","AS2863619","g9","L6200-26","in 10mM DMSO","CDK","Cell Cycle","AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells.",405.24,"2241300-51-4",{"v":60,"d":"60.00"},148.06,{"v":81,"d":"81.00"},199.88,"http://www.selleckchem.com/products/as2863619.html","C16H14Cl2N8O","Free Base","N/A","Cl.Cl.CC1=NC2=C([NH]1)C=CC(=C2)[N]3C4=C(C=NC=C4)N=C3C5=NON=C5N",2.468,6,2,2]
["S8951","TED-347","h9","L6200-26","in 10mM DMSO","TEAD,YAP","Hippo","TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.",{"v":313.7,"d":"313.70"},"2378626-29-8",{"v":69,"d":"69.00"},219.96,"˂1","N/A","http://www.selleckchem.com/products/ted-347.html","C15H11ClF3NO","Free Base","N/A","FC(F)(F)C1=CC=CC(=C1)NC2=CC=CC=C2C(=O)CCl",4.594,1,1,5]
["S8953","ASP4132","a10","L6200-26","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.",937.06,"1640294-30-9",{"v":100,"d":"100.00"},106.72,"<1","N/A","http://www.selleckchem.com/products/asp4132.html","C46H51F3N6O8S2","Free Base","N/A","COC1=NC=C(CN2CCC(CC2)C3=CC=C4[NH]C(=NC4=C3)C(=O)N5CCN(CC5)CC6=CC=C(C=C6)C(F)(F)F)C=C1.CC7=CC=C(C=C7)[S](O)(=O)=O.CC8=CC=C(C=C8)[S](O)(=O)=O",8.594,4,1,10]
["S8962","BRD3308","b10","L6200-26","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","BRD3308 is a potant and highly selective inhibitor of HDAC3 with IC50 of 54 nM, 1.26 μM and 1.34 μM for HDAC3, HDAC1 and HDAC2, respectively. BRD3308 activates HIV-1 transcription. BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines (glucolipotoxic stress) and increases functional insulin release.",287.29,"1550053-02-5",{"v":57,"d":"57.00"},198.41,"<1","N/A","http://www.selleckchem.com/products/brd3308.html","C15H14FN3O2","Free Base","N/A","CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=C(F)C=C2N",1.193,2,3,3]
["S8970","HQNO","c10","L6200-26","in 10mM DMSO","Others","Metabolism","HQNO (2-heptyl-4-hydroxyquinoline-N-oxide) is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione.",259.34,"341-88-8",{"v":9,"d":"9.00"},{"v":34.7,"d":"34.70"},"<1","N/A","http://www.selleckchem.com/products/hqno.html","C16H21NO2","Free Base","2-heptyl-4-hydroxyquinoline-N-oxide","CCCCCCCC1=CC(=O)C2=CC=CC=C2N1O",4.709,1,0,6]
["S0018","Verdiperstat","d10","L6200-26","in 10mM DMSO","Peroxidases","Metabolism","Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.",253.32,"890655-80-8",{"v":51,"d":"51.00"},201.33,"<1","N/A","http://www.selleckchem.com/products/verdiperstat.html","C11H15N3O2S","free base","AZD-3241, BHV-3241","CC(C)OCCN1C(=S)NC(=O)C2=C1C=C[NH]2",{"v":2.27,"d":"2.270"},2,2,4]
["S0178","GLX351322","e10","L6200-26","in 10mM DMSO","NADPH-oxidase","Immunology & Inflammation","GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.",431.51,"835598-94-2",{"v":20,"d":"20.00"},46.35,"<1","N/A","http://www.selleckchem.com/products/glx351322.html","C21H25N3O5S","free base","N/A","CCOC(=O)C1=C(NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3)SC4=C1CCC4",{"v":2.15,"d":"2.150"},5,1,7]
["S0185","BMS-5","f10","L6200-26","in 10mM DMSO","LIM kinase","Cell Cycle","BMS-5 (LIMKi 3) is a potent inhibitor of LIM kinases (LIMK) with IC50 of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.",431.29,"1338247-35-0",{"v":86,"d":"86.00"},{"v":199.4,"d":"199.40"},"<1","N/A","http://www.selleckchem.com/products/bms-5.html","C17H14Cl2F2N4OS","free base","LIMKi 3","CC(C)C(=O)NC1=NC=C(S1)C2=CC(=N[N]2C3=C(Cl)C=CC=C3Cl)C(F)F",5.615,3,1,5]
["S0219","ML241 hydrochloride","g10","L6200-26","in 10mM DMSO","ATPase","Transmembrane Transporters","ML241 hydrochloride is a potent and selective inhibitor of p97 with IC50 of 0.11 μM and 3.5 μM for p97 ATPase and UbG76V–GFP, respectively.",408.92,"2070015-13-1",{"v":74,"d":"74.00"},180.96,"<1","N/A","http://www.selleckchem.com/products/ml-241-hcl.html","C23H25ClN4O","free base","N/A","Cl.C1CCC2=C(NCC3=CC=CC=C3)N=C(N=C2C1)N4CCOC5=C4C=CC=C5",5.964,3,1,4]
["S0225","IMR-1A","h10","L6200-26","in 10mM DMSO","Notch","Neuronal Signaling","IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.",325.36,"331862-41-0",{"v":6,"d":"6.00"},18.44,"<1","N/A","http://www.selleckchem.com/products/imr-1a.html","C13H11NO5S2","free base","N/A","COC1=CC(=CC=C1OCC(O)=O)\\C=C/2SC(=S)NC2=O",{"v":2.29,"d":"2.290"},4,1,5]
["S0279","Dimethylenastron","a11","L6200-26","in 10mM DMSO","HSP (HSP90),Kinesin","Cytoskeletal Signaling","Dimethylenastron is a potent, specific and reversible inhibitor of kinesin Eg5 (kinesin-5/kinesin spindle protein, KSP) with IC50 of 200 nM. Dimethylenastron induces mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.",302.39,"863774-58-7",{"v":60,"d":"60.00"},198.42,"<1","N/A","http://www.selleckchem.com/products/dimethylenastron.html","C16H18N2O2S","free base","Eg5 Inhibitor III","CC1(C)CC(=O)C2=C(C1)NC(=S)NC2C3=CC=CC(=C3)O",2.806,1,3,1]
["S0294","HSF1A","b11","L6200-26","in 10mM DMSO","HSP (HSP90)","Cytoskeletal Signaling","HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.",409.52,"1196723-93-9",{"v":82,"d":"82.00"},200.23,"<1","N/A","http://www.selleckchem.com/products/hsf1a.html","C21H19N3O2S2","free base","N/A","CCC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=N[N]2C3=CC=CC=C3)C4=CC=CS4",5.511,3,1,6]
["S0407","XCT790","c11","L6200-26","in 10mM DMSO","Apoptosis related,Estrogen/progestogen Receptor","Endocrinology & Hormones","XCT-790 (Compound 12) is a potent and selective inverse agonist for estrogen-related receptor α (ERRα) with IC50 of 0.37 μM. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ. XCT-790 (Compound 12) significantly inhibits in vivo tumor growth and angiogenesis, and induces apoptosis.",596.42,"725247-18-7",{"v":8,"d":"8.00"},13.41,"<1","N/A","http://www.selleckchem.com/products/xct-790.html","C23H13F9N4O3S","free base","Compound 12","COC1=CC(=CC=C1OCC2=C(C=C(C=C2)C(F)(F)F)C(F)(F)F)\\C=C(C#N)\\C(=O)NC3=NN=C(S3)C(F)(F)F",6.179,5,1,10]
["S0425","TBK1/IKKε-IN-2","d11","L6200-26","in 10mM DMSO","IκB/IKK,TBK1","NF-κB","TBK1/IKKε-IN-2 (Ikk epsilon-in-1, IKKε-IN-1, MDK10496) is a dual inhibitor of TBK1 and IKKε.",457.52,"1292310-49-6",{"v":60,"d":"60.00"},131.14,"<1","N/A","http://www.selleckchem.com/products/tbk1-ikk-in-1.html","C26H27N5O3","free base","Ikk epsilon-in-1, IKKε-IN-1, MDK10496","N#CC1=C(OC2CCOCC2)C=CC(=C1)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5",3.622,5,1,6]
["S0444","Indibulin","e11","L6200-26","in 10mM DMSO","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Indibulin (ZIO 301, D 24851, Zybulin) is an orally applied inhibitor of tubulin assembly with potent anticancer activity. Indibulin induces mitotic arrest and apoptosis.",389.83,"204205-90-3",{"v":40,"d":"40.00"},102.61,"<1","N/A","http://www.selleckchem.com/products/Indibulin.html","C22H16ClN3O2","free base","ZIO 301, D 24851, Zybulin","ClC1=CC=C(C[N]2C=C(C(=O)C(=O)NC3=CC=NC=C3)C4=CC=CC=C24)C=C1",4.097,3,1,5]
["S0458","KY1220","f11","L6200-26","in 10mM DMSO","Ras,Wnt/beta-catenin","Stem Cells & Wnt","KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.",314.32,"292168-79-7",{"v":63,"d":"63.00"},200.43,"<1","N/A","http://www.selleckchem.com/products/ky1220.html","C14H10N4O3S","free base","N/A","[O-][N+](=O)C1=CC=C(C=C1)[N]2C=CC=C2\\C=C\\3NC(=S)NC3=O",2.892,1,2,3]
["S0507","CBL0137","g11","L6200-26","in 10mM DMSO","NF-κB,p53","NF-κB","CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.",336.43,"1197996-80-7",{"v":15,"d":"15.00"},44.59,"<1","N/A","http://www.selleckchem.com/products/cbl-0137.html","C21H24N2O2","free base","Curaxin-137, CBL-C137, CBLC137","CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",3.338,2,1,6]
["S0707","Silmitasertib (CX-4945) sodium salt","h11","L6200-26","in 10mM DMSO","Casein Kinase","Metabolism","Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.",371.75,"1309357-15-0",{"v":74,"d":"74.00"},199.06,{"v":74,"d":"74.00"},199.06,"http://www.selleckchem.com/products/silmitasertib-sodium-salt.html","C19H11ClN3NaO2","sodium","CX-4945 sodium salt","[Na+].[O-]C(=O)C1=CC2=C(C=C1)C3=C(C=CN=C3)C(=N2)NC4=CC(=CC=C4)Cl",2.683,2,1,3]
["S0777","Isuzinaxib (APX-115 free base)","a2","L6200-27","in 10mM DMSO","CCR,Interleukins,NADPH-oxidase,TNF-alpha","Immunology & Inflammation","Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.",279.34,"1270084-92-8",{"v":56,"d":"56.00"},200.47,"<1","N/A","http://www.selleckchem.com/products/apx-115-free-base.html","C17H17N3O","free base","Ewha-18278 free base","CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3",2.994,2,1,4]
["S0785","Apilimod (STA-5326) mesylate","b2","L6200-27","in 10mM DMSO","Interleukins,PIKfyve","Immunology & Inflammation","Apilimod (STA-5326) mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.",{"v":610.7,"d":"610.70"},"870087-36-8",{"v":60,"d":"60.00"},98.25,{"v":100,"d":"100.00"},163.75,"http://www.selleckchem.com/products/apilimod-mesylate.html","C25H34N6O8S2","mesylate","STA-5326 mesylate","CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4.C[S](O)(=O)=O.C[S](O)(=O)=O",3.657,6,1,8]
["S0818","STAT3-IN-1","c2","L6200-27","in 10mM DMSO","STAT","JAK/STAT","STAT3-IN-1 (compound 7d)  is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.",475.53,"2059952-75-7",{"v":95,"d":"95.00"},199.78,"<1","N/A","http://www.selleckchem.com/products/stat3-in-1.html","C28H29NO6","free base","N/A","COC1=CC(=CC(=C1)OC)\\C=C\\C2=CC=C(NC(=O)\\C=C\\C3=CC(=C(OC)C(=C3)OC)OC)C=C2",4.986,6,1,10]
["S0819","BL-918","d2","L6200-27","in 10mM DMSO","ULK","Autophagy","BL-918 is a potent, orally active activator of UNC-51-like kinase 1 (ULK1) with EC50 of 24.14 nM and Kd of 0.719 μM. BL-918 induces cytoprotective autophagy for Parkinson's disease treatment.",533.44,"2101517-69-3",{"v":100,"d":"100.00"},187.46,"<1","N/A","http://www.selleckchem.com/products/bl-918.html","C23H15F8N3OS","free base","N/A","FC1=CC(=C(NC(=O)C(NC(=S)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C3=CC=CC=C3)C=C1)F",7.163,1,3,9]
["S2176","Tenovin-3","e2","L6200-27","in 10mM DMSO","p53,Sirtuin","DNA Damage/DNA Repair","Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.",327.44,"1011301-27-1",{"v":65,"d":"65.00"},198.51,"<1","N/A","http://www.selleckchem.com/products/tenovin-3.html","C18H21N3OS","free base","N/A","CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(N)C=C2",{"v":4.42,"d":"4.420"},1,3,5]
["S3205","Perillaldehyde","f2","L6200-27","in 10mM DMSO","AhR,CCR,Nrf2,ROS","Metabolism","Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.",150.22,"18031-40-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/perillaldehyde.html","C10H14O","free base","Perilladehyde, Perillal, PAE, PA","CC(=C)C1CCC(=CC1)C=O",2.668,1,0,2]
["S3213","Veratryl alcohol","g2","L6200-27","in 10mM DMSO","Others","Others","Veratryl alcohol (VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol), a secondary metabolite of some lignin degrading fungi, is the natural substrate of Lignin peroxidase (LiP).",168.19,"93-03-8","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/veratryl-alcohol.html","C9H12O3","free base","VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol","COC1=C(OC)C=C(CO)C=C1",1.192,2,1,3]
["S3220","Trigonelline","h2","L6200-27","in 10mM DMSO","Akt,Anti-infection,Microtubule Associated,Phospholipase (e.g. PLA),PI3K","Metabolism","Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.",137.14,"535-83-1",{"v":50,"d":"50.00"},364.59,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/trigonelline.html","C7H7NO2","free base","Trigenolline","C[N+]1=CC(=CC=C1)C([O-])=O",{"v":-0.41,"d":"-0.410"},0,0,1]
["S3222","Raspberry ketone glucoside","a3","L6200-27","in 10mM DMSO","ROS","Immunology & Inflammation","Raspberry ketone glucoside (RKG), a natural product in raspberry fruit,  is an antioxidant that has the inhibitory effect on the melanin synthesis.",326.34,"38963-94-9",{"v":100,"d":"100.00"},306.43,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/raspberry-ketone-glucoside.html","C16H22O7","free base","RKG","CC(=O)CCC1=CC=C(OC2OC(CO)C(O)C(O)C2O)C=C1",-0.121,3,4,6]
["S3223","L-Quebrachitol","b3","L6200-27","in 10mM DMSO","NF-κB,RUNX,TGF-beta/Smad,Wnt/beta-catenin","Cell Cycle","L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.",194.18,"642-38-6",{"v":100,"d":"100.00"},514.99,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/l-quebrachitol.html","C7H14O6","free base","L-QCT","COC1C(O)C(O)C(O)C(O)C1O",-2.656,1,5,1]
["S3224","Cinobufagin","c3","L6200-27","in 10mM DMSO","Akt,Apoptosis related,ATM/ATR,Bcl-2,Caspase,CDK,Chk,PI3K","Cell Cycle","Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT  and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.",442.54,"470-37-1",{"v":100,"d":"100.00"},225.97,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cinobufagin.html","C26H34O6","free base","Cinobufagine","CC(=O)OC1C2OC23C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C6=COC(=O)C=C6",2.593,5,1,3]
["S3227","5,7-Dimethoxyflavone","d3","L6200-27","in 10mM DMSO","BCRP,P450 (e.g. CYP17)","Metabolism","5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.",282.29,"21392-57-4",{"v":100,"d":"100.00"},354.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/5-7-dimethoxyflavone.html","C17H14O4","free base","5,7-DMF","COC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)OC",3.103,4,0,3]
["S3235","Sinapine","e3","L6200-27","in 10mM DMSO","P-gp","Transmembrane Transporters","Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.",310.36,"18696-26-9",{"v":100,"d":"100.00"},322.21,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/sinapine.html","C16H24NO5","free base","N/A","COC1=C(O)C(=CC(=C1)\\C=C\\C(=O)OCC[N+](C)(C)C)OC",0.662,4,1,8]
["S3238","Resibufogenin","f3","L6200-27","in 10mM DMSO","Akt,Apoptosis related,Bcl-2,Caspase,CDK,GSK-3,Mixed Lineage Kinase,PI3K,RIP kinase,ROS,Wnt/beta-catenin","Apoptosis","Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.",384.51,"465-39-4",{"v":100,"d":"100.00"},260.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/resibufogenin.html","C24H32O4","free base","Bufogenin, Recibufogenin","CC12CCC(O)CC1CCC3C2CCC4(C)C(CC5OC345)C6=COC(=O)C=C6",3.113,3,1,1]
["S3241","Loureirin A","g3","L6200-27","in 10mM DMSO","Akt,PI3K","PI3K/Akt/mTOR","Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.",286.32,"119425-89-7",{"v":100,"d":"100.00"},349.26,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/loureirin-a.html","C17H18O4","free base","N/A","COC1=CC=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC",{"v":3.45,"d":"3.450"},3,1,6]
["S3242","Loureirin B","h3","L6200-27","in 10mM DMSO","Calcium Channel,ERK,JNK,PAI-1,Potassium Channel","Metabolism","Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.",316.35,"119425-90-0",{"v":100,"d":"100.00"},316.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/loureirin-b.html","C18H20O5","free base","LB, LrB","COC1=CC(=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC)OC",3.434,4,1,7]
["S3255","Pectolinarigenin","a4","L6200-27","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).",314.29,"520-12-7",{"v":100,"d":"100.00"},318.18,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/pectolinarigenin.html","C17H14O6","free base","N/A","COC1=CC=C(C=C1)C2=CC(=O)C3=C(O)C(=C(O)C=C3O2)OC",2.619,4,2,3]
["S3256","Tectochrysin","b4","L6200-27","in 10mM DMSO","Apoptosis related,NF-κB","NF-κB","Tectochrysin (Techtochrysin, NSC 80687) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin significantly increases the expression of DR3, DR4 and Fas and inhibits activity of NF-κB. Tectochrysin induces apoptotic cell death.",268.26,"520-28-5",{"v":7,"d":"7.00"},26.09,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/tectochrysin.html","C16H12O4","free base","Techtochrysin, NSC 80687","COC1=CC(=C2C(=O)C=C(OC2=C1)C3=CC=CC=C3)O",2.878,3,1,2]
["S3261","Myrislignan","c4","L6200-27","in 10mM DMSO","Anti-infection,COX,Interleukins,NF-κB,NOS,TNF-alpha","Immunology & Inflammation","Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.",374.43,"171485-39-5",{"v":100,"d":"100.00"},267.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/myrislignan.html","C21H26O6","free base","N/A","COC1=C(O)C=CC(=C1)C(O)C(C)OC2=C(OC)C=C(CC=C)C=C2OC",{"v":3.98,"d":"3.980"},4,2,9]
["S3262","Scopolin","d4","L6200-27","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","Scopolin,  a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.",354.31,"531-44-2",{"v":100,"d":"100.00"},282.24,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/scopolin.html","C16H18O9","free base","N/A","COC1=CC2=C(OC(=O)C=C2)C=C1OC3OC(CO)C(O)C(O)C3O",-0.289,5,4,4]
["S3270","Genipin 1-O-beta-D-gentiobioside","e4","L6200-27","in 10mM DMSO","Anti-infection","Immunology & Inflammation","Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.",550.51,"29307-60-6",{"v":100,"d":"100.00"},181.65,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/genipin-1-o-beta-d-gentiobioside.html","C23H34O15","free base","GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside","COC(=O)C1=COC(OC2OC(COC3OC(CO)C(O)C(O)C3O)C(O)C(O)C2O)C4C1CC=C4CO",-3.813,7,8,9]
["S3273","Hypericin","f4","L6200-27","in 10mM DMSO","Hydroxylase,MAO,P450 (e.g. CYP17),PKC,Reverse Transcriptase,Telomerase","Metabolism","Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).",504.44,"548-04-9",{"v":100,"d":"100.00"},198.24,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hypericin.html","C30H16O8","free base","Hyp, HY","CC1=C2C3=C(C)C=C(O)C4=C3C5=C6C2=C(C(=C1)O)C(=O)C7=C6C(=C(O)C=C7O)C8=C(O)C=C(O)C(=C58)C4=O",{"v":5.04,"d":"5.040"},2,6,0]
["S3274","Glucosyl-vitexin","g4","L6200-27","in 10mM DMSO","Peroxidases","Metabolism","Glucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity.",610.52,"76135-82-5",{"v":100,"d":"100.00"},163.79,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/glucosyl-vitexin.html","C27H30O16","free base","Glucosylvitexin","OCC1OC(OC2C(O)C(O)C(CO)OC2OC3=C4OC(=CC(=O)C4=C(O)C=C3O)C5=CC=C(O)C=C5)C(O)C(O)C1O",-1.509,6,10,7]
["S3280","Linderene","h4","L6200-27","in 10mM DMSO","Bacterial","Immunology & Inflammation","Linderene (Lindenenol) is a furanosesquiterpenoid isolated from Lindera pulcherrima with antibacterial and antioxidant activities.",{"v":230.3,"d":"230.30"},"26146-27-0",{"v":100,"d":"100.00"},434.22,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/linderene.html","C15H18O2","free base","Lindenenol","CC1=COC2=C1C(O)C3C(=C)C4CC4C3(C)C2",2.294,1,1,0]
["S3283","Marmesin","a5","L6200-27","in 10mM DMSO","COX,Lipoxygenase","Immunology & Inflammation","Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.",246.26,"13849-08-6",{"v":100,"d":"100.00"},406.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/marmesin.html","C14H14O4","free base","S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin","CC(C)(O)C1CC2=CC3=C(OC(=O)C=C3)C=C2O1",2.029,3,0,1]
["S3291","Myristicin","b5","L6200-27","in 10mM DMSO","MAO,P450 (e.g. CYP17)","Metabolism","Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.",192.21,"607-91-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/myristicin.html","C11H12O3","free base","Myristicine","COC1=C2OCOC2=CC(=C1)CC=C",2.589,3,0,3]
["S3296","Hispidulin","c5","L6200-27","in 10mM DMSO","Akt,AMPK,Apoptosis related,Mitochondrial Metabolism,PI3K,Pim","JAK/STAT","Hispidulin (Dinatin), an active natrual ingredient in a number of traditional Chinese medicinal herbs, exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71 μM. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.",300.26,"1447-88-7",{"v":100,"d":"100.00"},333.04,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/hispidulin.html","C16H12O6","free base","Dinatin","COC1=C(O)C=C2OC(=CC(=O)C2=C1O)C3=CC=C(O)C=C3",2.394,3,3,2]
["S3298","Caulophylline (N-Methylcytisine)","d5","L6200-27","in 10mM DMSO","AChR,IκB/IKK,NF-κB,Peroxidases","Neuronal Signaling","Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.",204.27,"486-86-2 (63699-79-6, 207-643-8)",{"v":100,"d":"100.00"},489.55,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/caulophylline-n-methylcytisine-.html","C12H16N2O","free base","Caulophyllin, NMC","CN1CC2CC(C1)C3=CC=CC(=O)N3C2",0.198,1,0,0]
["S3301","Cynarin","e5","L6200-27","in 10mM DMSO","CD markers,Glutathione,Nrf2,ROS","Immunology & Inflammation","Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.",516.45,"30964-13-7",{"v":100,"d":"100.00"},193.63,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/cynarin.html","C25H24O12","free base","Cynarine","OC1CC(CC(OC(=O)/C=C/C2=CC=C(O)C(=C2)O)C1O)(OC(=O)\\C=C\\C3=CC=C(O)C(=C3)O)C(O)=O",1.687,5,6,9]
["S3302","β,β-dimethyl-acryl-alkannin","f5","L6200-27","in 10mM DMSO","Others","Others","β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) is a napthoquinone isolated from roots of Arnebia nobilis Reichb.f. that has the potential to be used as an anti-aging ingredient.",{"v":370.4,"d":"370.40"},"34539-65-6",{"v":8,"d":"8.00"},{"v":21.6,"d":"21.60"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/b-b-dimethyl-acryl-alkannin.html","C21H22O6","free base","AN-I, β,β-Dimethylacrylalkannin","CC(C)=CCC(OC(=O)C=C(C)C)C1=CC(=O)C2=C(C(=CC=C2O)O)C1=O",{"v":4.37,"d":"4.370"},4,2,6]
["S3305","Medicagenic acid","g5","L6200-27","in 10mM DMSO","Others","Metabolism","Medicagenic acid (Castanogenin), a bioactive triterpenoid pentacyclic glycoside isolated from Herniaria glabra L., has low xanthine oxidase, collagenase, elastase, and tyrosinase inhibitory activity.",502.68,"599-07-5",{"v":100,"d":"100.00"},198.93,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/medicagenic-acid.html","C30H46O6","free base","Castanogenin","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(O)=O)C2C1)C(O)=O",4.623,2,2,2]
["S6760","LM22B-10","h5","L6200-27","in 10mM DMSO","Akt,ERK,Trk receptor","Protein Tyrosine Kinase","LM22B-10 is a small molecule TrkB/TrkC neurotrophin receptor co-activator, LM22B-10 selectively activates TrkB, TrkC, AKT and ERK in vivo and in vitro.",485.01,"342777-54-2",{"v":97,"d":"97.00"},{"v":200,"d":"200.00"},"<1","N/A","http://www.selleckchem.com/products/lm2b-10.html","C27H33ClN2O4","free base","N/A","OCCN(CCO)C1=CC=C(C=C1)C(C2=CC=C(Cl)C=C2)C3=CC=C(C=C3)N(CCO)CCO",3.919,0,4,13]
["S6811","Miransertib (ARQ-092)","a6","L6200-27","in 10mM DMSO","Akt","PI3K/Akt/mTOR","Miransertib (ARQ-092) is a potent, selective and orally bioavailable allosteric inhibitor of Akt with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.",432.52,"1313881-70-7",{"v":8,"d":"8.00"},{"v":18.5,"d":"18.50"},"<1","N/A","http://www.selleckchem.com/products/miransertib.html","C27H24N6","free base","N/A","NC1=C(C=CC=N1)C2=NC3=C(N=C(C=C3)C4=CC=CC=C4)[N]2C5=CC=C(C=C5)C6(N)CCC6",4.598,3,2,4]
["S6845","GRL0617","b6","L6200-27","in 10mM DMSO","DUB,SARS-CoV","Ubiquitin","GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro)/deubiquitinase with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity.",304.39,"1093070-16-6",{"v":65,"d":"65.00"},213.54,"<1","N/A","http://www.selleckchem.com/products/grl0617.html","C20H20N2O","free base","N/A","CC(NC(=O)C1=C(C)C=CC(=C1)N)C2=CC=CC3=CC=CC=C23",3.647,1,2,3]
["S6850","NE 52-QQ57","c6","L6200-27","in 10mM DMSO","cAMP,COX,GPR,Interleukins,NOS,PGES,TNF-alpha","GPCR & G Protein","NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).",416.52,"1401728-56-0",{"v":20,"d":"20.00"},48.02,"<1","N/A","http://www.selleckchem.com/products/ne-52-qq57.html","C24H28N6O","free base","N/A","CCC1=N[N]2C(=CC(=NC2=C1CC3=CC=C(C=C3)C4=NN=C(O4)C5CCNCC5)C)C",3.242,5,1,5]
["S6851","RA-190","d6","L6200-27","in 10mM DMSO","Autophagy,p53,Proteasome","Ubiquitin","RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.",596.76,"1617495-03-0",{"v":100,"d":"100.00"},167.57,"<1","N/A","http://www.selleckchem.com/products/ra-190.html","C28H23Cl5N2O2","free base","N/A","Cl.NC(CC1=CC=CC=C1)C(=O)N2CC(=C/C3=CC(=C(Cl)C=C3)Cl)/C(=O)C(/C2)=C\\C4=CC(=C(Cl)C=C4)Cl",7.285,2,1,5]
["S6854","Triazavirin","e6","L6200-27","in 10mM DMSO","DNA/RNA Synthesis,Influenza Virus,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.",{"v":286.2,"d":"286.20"},"928659-17-0",{"v":57,"d":"57.00"},199.16,{"v":20,"d":"20.00"},69.88,"http://www.selleckchem.com/products/triazavirin.html","C5H7N6NaO5S","free base","TZV, Riamilovir","O.O.[Na+].CSC1=NC2=NN=C(C(=O)N2[N-]1)[N+]([O-])=O",-0.184,4,0,2]
["S6877","EOAI3402143","f6","L6200-27","in 10mM DMSO","Apoptosis related,DUB","Ubiquitin","EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.",503.42,"1699750-95-2",{"v":100,"d":"100.00"},198.64,"<1","N/A","http://www.selleckchem.com/products/eoai3402143.html","C25H28Cl2N4O3","free base","N/A","CCCC(NC(=O)/C(=C/C1=C(Cl)C=CC(=N1)Cl)C#N)C2=CC=C(OCCN3CCOCC3)C=C2",4.911,4,1,10]
["S6878","GSK2643943A","g6","L6200-27","in 10mM DMSO","DUB","Ubiquitin","GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.",{"v":277.3,"d":"277.30"},"2449301-27-1",{"v":55,"d":"55.00"},198.34,"<1","N/A","http://www.selleckchem.com/products/gsk2643943a.html","C17H12FN3","free base","N/A","NC1=C(C#N)C2=C([NH]1)C=C(\\C=C\\C3=CC(=CC=C3)F)C=C2",3.571,0,2,2]
["S6880","SRT-1460","h6","L6200-27","in 10mM DMSO","Sirtuin","DNA Damage/DNA Repair","SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.",{"v":507.6,"d":"507.60"},"925432-73-1",{"v":20,"d":"20.00"},{"v":39.4,"d":"39.40"},"<1","N/A","http://www.selleckchem.com/products/srt-1460.html","C26H29N5O4S","free base","N/A","COC1=C(OC)C(=CC(=C1)C(=O)NC2=CC=CC=C2C3=C[N]4C(=CSC4=N3)CN5CCNCC5)OC",2.694,5,2,8]
["S6882","HI-TOPK-032","a7","L6200-27","in 10mM DMSO","Apoptosis related,Caspase,ERK,p53,PARP,TOPK","MAPK","HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.",{"v":369.4,"d":"369.40"},"487020-03-1",{"v":4,"d":"4.00"},10.83,"<1","N/A","http://www.selleckchem.com/products/hi-topk-032.html","C20H11N5OS","free base","N/A","O=C(NC1=CC2=C(C#N)C3=C(N=C4C=CC=CC4=N3)[N]2C=C1)C5=CC=CS5",3.567,3,1,2]
["S6886","1-Aminobenzotriazole","b7","L6200-27","in 10mM DMSO","Histone Acetyltransferase,P450 (e.g. CYP17),Transferase","Metabolism","1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).",134.14,"1614-12-6",{"v":27,"d":"27.00"},201.28,{"v":27,"d":"27.00"},201.28,"http://www.selleckchem.com/products/1-aminobenzotriazole.html","C6H6N4","free base","ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987","N[N]1N=NC2=CC=CC=C12",0.943,2,1,0]
["S6889","Monomethyl Fumarate","c7","L6200-27","in 10mM DMSO","Apoptosis related,Autophagy,GPR","GPCR & G Protein","Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.",{"v":130.1,"d":"130.10"},"2756-87-8",{"v":26,"d":"26.00"},199.85,{"v":20,"d":"20.00"},153.73,"http://www.selleckchem.com/products/monomethyl-fumarate.html","C5H6O4","free base","MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate","COC(=O)\\C=C\\C(O)=O",0.264,3,0,3]
["S7773","CDKI-73","d7","L6200-27","in 10mM DMSO","CDK","Cell Cycle","CDKI-73 (LS-007) is a potent CDK inhibitor in vitro with IC50 of 8.17 nM, 3.27 nM, 8.18 nM, and 5.78 nM for CDK1, CDK2, CDK4, and CDK9, respectively. CDKI-73 induces apoptosis in cancer cells. CDKI-73 is an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia.",394.45,"1421693-22-2",{"v":79,"d":"79.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/cdki-73.html","C15H15FN6O2S2","free base","N/A","CNC1=NC(=C(S1)C2=C(F)C=NC(=N2)NC3=CC(=CC=C3)[S](N)(=O)=O)C",2.359,5,3,5]
["S8730","BAY 1251152","e7","L6200-27","in 10mM DMSO","CDK","Cell Cycle","BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.",404.43,"1610358-56-9",{"v":81,"d":"81.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/bay1251152.html","C19H18F2N4O2S","free base","(+)-BAY-1251152","COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)C[S](C)(=N)=O",4.677,4,1,6]
["S8929","GCN2iB","f7","L6200-27","in 10mM DMSO","Serine/threonin kinase","Metabolism","GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.",451.83,"2183470-12-2",{"v":15,"d":"15.00"},{"v":33.2,"d":"33.20"},"<1","N/A","http://www.selleckchem.com/products/gcn2ib.html","C18H12ClF2N5O3S","free base","N/A","COC1=NC=C(Cl)C=C1[S](=O)(=O)NC2=C(F)C(=C(F)C=C2)C#CC3=CN=C(N)N=C3",2.869,6,2,6]
["S8974","GSK2795039","g7","L6200-27","in 10mM DMSO","Apoptosis related,NADPH-oxidase,ROS","Immunology & Inflammation","GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. GSK2795039 inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.",450.56,"1415925-18-6",{"v":90,"d":"90.00"},199.75,"<1","N/A","http://www.selleckchem.com/products/gsk2795039.html","C23H26N6O2S","free base","N/A","CC(C)[N]1C=C(C2=CC=C3CCN(C)C3=C2)C4=C1N=CC=C4N[S](=O)(=O)C5=N[N](C)C=C5",3.536,4,1,5]
["S8978","Mitoquinone (MitoQ10) mesylate","h7","L6200-27","in 10mM DMSO","ROS","Immunology & Inflammation","Mitoquinone mesylate (MitoQ, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria-targeted antioxidant that blocks H2O2-induced intracellular ROS responses and protects against oxidative damage. This product is a waxy solid.",678.81,"845959-50-4","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/mitoquinone-mesylate.html","C38H47O7PS","mesylate","MitoQ, Mitoubiquinone","COC1=C(OC)C(=O)C(=C(C)C1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.C[S]([O-])(=O)=O",6.675,4,0,16]
["S8992","RBN012759","a8","L6200-27","in 10mM DMSO","PARP","DNA Damage/DNA Repair","RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.",378.46,"2360851-29-0",{"v":76,"d":"76.00"},200.81,"<1","N/A","http://www.selleckchem.com/products/rbn012759.html","C19H23FN2O3S","free base","N/A","OC1CCC(CC1)SCC2=NC3=CC(=CC(=C3C(=O)N2)F)OCC4CC4",2.941,3,2,6]
["S9602","Elraglusib","b8","L6200-27","in 10mM DMSO","Apoptosis related,GSK-3","PI3K/Akt/mTOR","Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.",404.35,"1034895-42-5",{"v":81,"d":"81.00"},200.32,"<1","N/A","http://www.selleckchem.com/products/9-ing-41.html","C22H13FN2O5","free base","9-ing-41","C[N]1C=C(C2=CC3=C(OCO3)C=C12)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(F)C=C6",3.339,5,1,2]
["S9604","IM156","c8","L6200-27","in 10mM DMSO","AMPK,Apoptosis related,OXPHOS","PI3K/Akt/mTOR","IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.",315.29,"1422365-93-2",{"v":63,"d":"63.00"},199.82,"<1","N/A","http://www.selleckchem.com/products/im156.html","C13H16F3N5O","free base","HL156A","FC(F)(F)OC1=CC=C(NC(=N)NC(=N)N2CCCC2)C=C1",3.622,1,2,7]
["S9605","Apcin","d8","L6200-27","in 10mM DMSO","APC,CDK,E3 Ligase","Ubiquitin","Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.",438.65,"300815-04-7",{"v":88,"d":"88.00"},200.62,"<1","N/A","http://www.selleckchem.com/products/apcin.html","C13H14Cl3N7O4","free base","N/A","CC1=NC=C([N]1CCOC(=O)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl)[N+]([O-])=O",2.035,5,2,9]
["S9611","ABTL-0812","e8","L6200-27","in 10mM DMSO","Akt,Autophagy,mTOR,ROS","PI3K/Akt/mTOR","ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.",296.44,"57818-44-7","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/abtl-0812.html","C18H32O3","free base","α-Hydroxylinoleic acid","CCCCC\\C=C/C\\C=C/CCCCCCC(O)C(O)=O",5.629,1,1,14]
["S9639","VX-803 (M4344)","f8","L6200-27","in 10mM DMSO","ATM/ATR,Chk","PI3K/Akt/mTOR","VX-803 (M4344, ATR inhibitor 2) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM. VX-803 (M4344) potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with IC50 of 8 nM. VX-803 (M4344) exhibits potential antineoplastic activity.",541.55,"1613191-99-3",{"v":15,"d":"15.00"},{"v":27.7,"d":"27.70"},"<1","N/A","http://www.selleckchem.com/products/vx803-m4344.html","C25H29F2N9O3","free base","ATR inhibitor 2","NC1=N[N]2C=C(F)C=NC2=C1C(=O)NC3=C(N4CCC(CC4)C(=O)N5CCN(CC5)C6COC6)C(=CN=C3)F",-0.338,6,2,5]
["S9649","Acelarin (NUC-1031)","g8","L6200-27","in 10mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Acelarin (NUC-1031, CPF-31, MTL-007, GTPL7389) is a DNA synthesis inhibitor with EC50 of 0.2 nM.",580.47,"840506-29-8",{"v":100,"d":"100.00"},172.27,"<1","N/A","http://www.selleckchem.com/products/acelarin-nuc-1031.html","C25H27F2N4O8P","free base","CPF-31, MTL-007, GTPL7389","CC(N[P](=O)(OCC1OC(N2C=CC(=NC2=O)N)C(F)(F)C1O)OC3=CC=CC=C3)C(=O)OCC4=CC=CC=C4",{"v":1.69,"d":"1.690"},7,3,12]
["S9687","H2DCFDA","h8","L6200-27","in 10mM DMSO","ROS","Immunology & Inflammation","H2DCFDA (DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) production.",487.29,"4091-99-0",{"v":97,"d":"97.00"},199.06,{"v":97,"d":"97.00"},199.06,"http://www.selleckchem.com/products/h2dcfda.html","C24H16Cl2O7","free base","DCFH-DA, 2',7'-Dichlorodihydrofluorescein diacetate","CC(=O)OC1=CC2=C(C=C1Cl)C(C3=C(O2)C=C(OC(C)=O)C(=C3)Cl)C4=C(C=CC=C4)C(O)=O",5.312,6,0,6]
["E1267","MDL-800","a9","L6200-27","in 10mM DMSO","Sirtuin","Epigenetics","MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation, and reduces proliferation of BEL-7405 hepatocellular carcinoma (HCC) cells with EC50 of 90.4 µM.",{"v":626.3,"d":"626.30"},"2275619-53-7",{"v":100,"d":"100.00"},159.67,"<1","N/A","https://www.selleckchem.com/products/mdl-800.html","C21H16BrCl2FN2O6S2","chloride","N/A","COC(=O)C1=C(C=CC(=C1)N[S](=O)(=O)C2=CC(=CC(=C2)Cl)Cl)[S](=O)(=O)NC3=C(C)C=C(F)C(=C3)Br",5.429,6,2,8]
["E1276","MK-0159","b9","L6200-27","in 10mM DMSO","CD markers","Transmembrane Transporters","MK-015(Compound 37)  is an inhibitor of CD38. MK-0159 inhibits human, mouse, and rat CD38 (cell-free assays) with IC50 values of 22, 3, and 70 nM, respectively. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.",{"v":400.5,"d":"400.50"},"2641484-61-7",{"v":80,"d":"80.00"},199.75,"<1","N/A","https://www.selleckchem.com/products/mk-0159.html","C20H24N4O3S","free base","Compound 37","COCCOC1CCC(CC1)NC(=O)C2=C3C=C[NH]C3=NC(=C2)C4=CN=CS4",1.972,5,2,7]
["E1330","Usp22i-S02","c9","L6200-27","in 10mM DMSO","DUB","Ubiquitin","Usp22i-S02(USP22-IN-1, compound S02) is a potent inhibitor of ubiquitin specific peptidase 22 (USP22). It showed anticancer activity by suppressing Foxp3 expression in T-regulatory cells.",338.41,"309735-96-4",{"v":68,"d":"68.00"},200.94,"<1","N/A","https://www.selleckchem.com/products/usp22i-s02.html","C22H18N4","free base","USP22-IN-1, compound S02","N#CC1=C2CCCCC2=C(NC3=CC=CC=C3)[N]4C5=CC=CC=C5N=C14",5.817,1,1,2]
["E1351","NF-κΒ activator 1","d9","L6200-27","in 10mM DMSO","NF-κΒ","NF-κΒ","NF-κΒ activator 1(Compound 32) is a potent NF-κΒ activator, with an EC50 of 0.9 μM.",314.34,"2387524-59-4",{"v":63,"d":"63.00"},200.42,"<1","N/A","https://www.selleckchem.com/products/nf-kb-activator-1.html","C16H11FN2O2S","free base","Compound 32","OC(=O)C1=CC=CC(=C1)C2=CSC(=N2)NC3=CC=CC=C3F",4.159,2,1,4]
["E2371","YLF-466D","e9","L6200-27","in 10mM DMSO","AMPK","PI3K/Akt/mTOR","YLF-466D is an AMPK activator that inhibits platelet aggregation with IC50 of 84 μM.",465.93,"1273323-67-3",{"v":93,"d":"93.00"},{"v":199.6,"d":"199.60"},"<1","N/A","https://www.selleckchem.com/products/ylf-466d.html","C29H20CINO3","free base","N/A","OC(=O)C1=CC=CC(=C1)CN2C(=O)C(/C3=CC=CC=C23)=C(C4=CC=CC=C4)/C5=CC=C(Cl)C=C5",6.293,2,0,5]
["E2902","Sodium Pyruvate","f9","L6200-27","in 10mM DMSO","Others","Others","Sodium Pyruvate(Sodium 2-oxopropanoate) is a compound produced in the glycolytic pathway. Sodium Pyruvate is a free radical scavenger that can scavenge ROS.",111.05,"113-24-6",{"v":4,"d":"4.00"},36.02,{"v":22,"d":"22.00"},198.11,"https://www.selleckchem.com/products/sodium-pyruvate.html","C3H4O3.Na","sodium","Sodium 2-oxopropanoate","[Na;v0].CC(=O)C(O)=O",-0.329,2,0,1]
["E2914","5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside","g9","L6200-27","in 10mM DMSO","Casein Kinase","Metabolism","5,6-Dichlorobenzimidazole riboside(DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. It trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.",319.14,"53-85-0",{"v":64,"d":"64.00"},200.54,"<1","N/A","https://www.selleckchem.com/products/5-6-dichlorobenzimidazole-1-beta-d-ribofuranoside.html","C12H12Cl2N2O4","dichloride","DRB","OCC1OC(C(O)C1O)[N]2C=NC3=CC(=C(Cl)C=C23)Cl",1.235,2,3,2]
["E2943","Pifithrin-β","h9","L6200-27","in 10mM DMSO","p53","Apoptosis","Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.",268.38,"60477-34-1",{"v":27,"d":"27.00"},{"v":100.6,"d":"100.60"},"<1","N/A","https://www.selleckchem.com/products/pifithrin-beta.html","C16H16N2S","free base","PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide","CC1=CC=C(C=C1)C2=C[N]3C4=C(CCCC4)SC3=N2",4.125,1,0,1]
["E2947","Recilisib","a10","L6200-27","in 10mM DMSO","AKT","PI3K/Akt/mTOR","Recilisib (ON01210, EX-RAD) is a radioprotectant that activates the activity of AKT and PI3K in cells. It has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug.",336.79,"334969-03-8",{"v":67,"d":"67.00"},198.94,"<1","N/A","https://www.selleckchem.com/products/recilisib.html","C16H13ClO4S","chloride","ON 01210, EX-RAD","OC(=O)C1=CC=C(C=C1)\\C=C\\[S](=O)(=O)CC2=CC=C(Cl)C=C2",3.175,3,0,5]
["E2988","Sulfosuccinimidyl oleate sodium","b10","L6200-27","in 10mM DMSO","Mitophagy","Autophagy","Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain with IC50 of 4 μM. It inhibits CD36 mediated LCFA transport. It exhibits anti-inflammatory effect.",482.59,"1212012-37-7",{"v":23,"d":"23.00"},47.66,"<1","N/A","https://www.selleckchem.com/products/sulfosuccinimidyl-oleate-sodium.html","C22H37NO7S.Na","sodium","N/A","[Na;v0].CCCCCCCCC=CCCCCCCCC(=O)ON1C(=O)CC(C1=O)[S](O)(=O)=O",{"v":5.4,"d":"5.400"},4,0,18]
["E1575","EN450","c10","L6200-27","in 10mM DMSO","NF-κB","NF-κB","EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. It interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D that induces the ternary complex formation between UBE2D and NFKB1. It exhibits anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.",288.75,"793719-01-4",{"v":58,"d":"58.00"},200.87,"<1","N/A","https://www.selleckchem.com/products/en450.html","C11H13ClN2O3S","free base","N/A","CN(C)[S](=O)(=O)C1=CC(=C(Cl)C=C1)NC(=O)C=C",1.429,3,1,4]
["E1579","UCL-TRO-1938","d10","L6200-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","UCL-TRO-1938 is a potent allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective and neural regeneration effects.",456.58,"2919575-27-0",{"v":30,"d":"30.00"},65.71,"<1","N/A","https://www.selleckchem.com/products/ucl-tro-1938.html","C27H32N6O","free base","N/A","CCN1CCN(CC1)C2=CC=C(NC3=CC(=CC=N3)NC4=C5N(CCC5=CC=C4)C(C)=O)C=C2",4.188,2,2,6]
["E1603","ACT001(DMAMCL)","e10","L6200-27","in 10mM DMSO","PAI-1","Metabolism","ACT001(DMAMCL, dimethylaminomicheliolide) is a PAI-1 inhibitor and exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo. It also exerts synergistic effects in combination with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway.",{"v":293.4,"d":"293.40"},"1403357-81-2",{"v":59,"d":"59.00"},201.09,{"v":59,"d":"59.00"},201.09,"https://www.selleckchem.com/products/act001-dmamcl.html","C17H27NO3","free base","DMAMCL, dimethylaminomicheliolide","CN(C)CC1C2CCC(=C3CCC(C)(O)C3C2OC1=O)C",1.913,2,0,2]
["E1714","B022","f10","L6200-27","in 10mM DMSO","NF-κB","NF-κB","B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with a Ki of 4.2 nM. B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.",397.88,"1202764-53-1",{"v":80,"d":"80.00"},201.07,"<1","N/A","https://www.selleckchem.com/products/b022.html","C19H16ClN5OS","free base","N/A","CC(O)(C#CC1=CC=C2CCN(C2=C1)C3=NC(=NC=C3Cl)N)C4=NC=CS4",3.525,3,1,4]
["E1716","SR9011","g10","L6200-27","in 10mM DMSO","Others","Metabolism","SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi.",479.04,"1379686-29-9",{"v":96,"d":"96.00"},{"v":200.4,"d":"200.40"},"<1","N/A","https://www.selleckchem.com/products/sr9011.html","C23H31ClN4O3S","free base","N/A","CCCCCNC(=O)N1CCC(CN(CC2=CC=C(S2)[N](=O)=O)CC3=CC=C(Cl)C=C3)C1",5.189,1,1,11]
["E1735","PK11007","h10","L6200-27","in 10mM DMSO","p53","Apoptosis","PK11007 is a thiol-reactive anticancer agent that stabilizes  p53  via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant  p53  cancer cell death by increasing reactive oxygen species (ROS) levels.",427.86,"874146-69-7",{"v":86,"d":"86.00"},{"v":201,"d":"201.00"},"<1","N/A","https://www.selleckchem.com/products/pk11007.html","C15H11ClFN5O3S2","free base","N/A","CC1=NN=C(NC(=O)C2=NC(=NC=C2Cl)[S](=O)(=O)CC3=CC=C(F)C=C3)S1",2.499,7,1,5]
["E1739","MST-312","a11","L6200-27","in 10mM DMSO","Telomerase","DNA Damage/DNA Repair","MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM).",380.35,"368449-04-1",{"v":76,"d":"76.00"},199.82,"<1","N/A","https://www.selleckchem.com/products/mst-312.html","C20H16N2O6","free base","Telomerase Inhibitor IX","OC1=CC=CC(=C1O)C(=O)NC2=CC(=CC=C2)NC(=O)C3=C(O)C(=CC=C3)O",2.431,2,6,4]
["E4443","S-Nitrosoglutathione","b11","L6200-27","in 10mM DMSO","Others","Others","S-nitrosoglutathione (GSNO, RVC-588, S-Nitroso-L-glutathione,Nitrosoglutathione) is an amino acid and nitric oxide donor that, under physiological conditions, spontaneously releases nitric oxide. S-nitrosoglutathione (GSNO) selectively inhibits platelet and NF-κB activation. It induces apoptosis in T cells in low concentrations (< 0.6 mM) while protecting T cells from apoptosis in higher concentrations (1-2 mM).",336.32,"57564-91-7",{"v":67,"d":"67.00"},199.22,{"v":17,"d":"17.00"},50.55,"https://www.selleckchem.com/products/s-nitrosoglutathione.html","C10H16N4O7S","free base","GSNO , RVC-588 , S-Nitroso-L-glutathione , Nitrosoglutathione","NC(CCC(=O)NC(CSN=O)C(=O)NCC(O)=O)C(O)=O",-4.295,5,3,11]
["S3575","Zandelisib","c11","L6200-27","in 10mM DMSO","PI3K","PI3K/Akt/mTOR","Zandelisib(ME-401; PWT-143) is an orally bioavailable inhibitor of the phosphatidylinositide 3-kinase (PI3K). It selectively inhibits the delta isoform of PI3K (p110δ)  and prevents the activation of the PI3K/AKT signaling pathway with an IC50 of 3.5 nM. It functions as an antineoplastic agent.",576.68,"1401436-95-0",{"v":13,"d":"13.00"},22.54,"<1","N/A","https://www.selleckchem.com/products/zandelisib.html","C31H38F2N8O","free base","ME-401; PWT-143","CN1CCC(CC1)C2=C(CC(C)(C)NC3=NC(=NC(=N3)[N]4C(=NC5=CC=CC=C45)C(F)F)N6CCOCC6)C=CC=C2",6.503,5,1,8]
["E2903","2,4-dihydroxybenzaldehyde","d11","L6200-27","in 10mM DMSO","Others","Others","2,4-Dihydroxybenzaldehyde exhibits antimicrobial as well as antioxidant properties.",138.12,"95-01-2",{"v":100,"d":"100.00"},724.01,"<1","N/A","https://www.selleckchem.com/products/2,4-dihydroxybenzaldehyde.html","C7H6O3","free base","N/A","OC1=CC(=C(C=O)C=C1)O",1.105,1,2,1]
["P1127","Pasireotide","e11","L6200-27","in 10mM DMSO","SSTR","Endocrinology & Hormones","Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor (SSTR) subtypes sst1,2,3 and sst5. It potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing’s disease.",1047.21,"396091-73-9",{"v":100,"d":"100.00"},95.49,"<1","N/A","https://www.selleckchem.com/products/pasireotide.html","C58H66N10O9","free base","SOM230","NCCCCC1NC(=O)C(CC2=C[NH]C3=CC=CC=C23)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(CC5=CC=CC=C5)NC(=O)C(CC6=CC=C(OCC7=CC=CC=C7)C=C6)NC1=O)OC(=O)NCCN)C8=CC=CC=C8",3.721,9,9,18]
["S4684","Sildenafil","f11","L6200-27","in 10mM DMSO","PDE","Metabolism","Sildenafil (Revatio, UK-92480, Viagra) is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.",474.58,"139755-83-2","N/A",">10","N/A","N/A","http://selleckchem.com/products/sildenafil.html","C22H30N6O4S","free base","Revatio, UK-92480, Viagra","CCCC1=N[N](C)C2=C1N=C(NC2=O)C3=CC(=CC=C3OCC)[S](=O)(=O)N4CCN(C)CC4",2.247,6,1,7]
["S1037","Perifosine (KRX-0401)","a2","L6200-28","in 10mM Water","Akt","PI3K/Akt/mTOR","Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.",461.66,"157716-52-4","<1","N/A",{"v":8,"d":"8.00"},17.33,"http://selleckchem.com/products/Perifosine.html","C25H52NO4P","free base","NSC639966, D21266","CCCCCCCCCCCCCCCCCCO[P]([O-])(=O)OC1CC[N+](C)(C)CC1",4.607,2,0,20]
["S1116","Palbociclib (PD-0332991) HCl","b2","L6200-28","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",483.99,"827022-32-2",{"v":3,"d":"3.00"},{"v":6.2,"d":"6.20"},{"v":30,"d":"30.00"},61.98,"http://selleckchem.com/products/PD-0332991.html","C24H29N7O2.HCl","Hydrochloride","N/A","Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O",3.183,5,2,5]
["S1135","Pemetrexed (LY-231514) disodium","c2","L6200-28","in 10mM Water","Apoptosis related,Autophagy,DHFR,DNA/RNA Synthesis,Thymidylate Synthase","Metabolism","Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.",471.37,"150399-23-8","<1","N/A",{"v":94,"d":"94.00"},199.42,"http://selleckchem.com/products/Pemetrexed-disodium.html","C20H19N5Na2O6","Disodium salt","LY-231514 disodium","[Na+].[Na+].NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O)N1",-1.804,3,4,9]
["S1149","Gemcitabine (LY-188011) HCl","d2","L6200-28","in 10mM Water","Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.",299.66,"122111-03-9","<1","N/A",{"v":19,"d":"19.00"},63.41,"http://selleckchem.com/products/Gemcitabine-Hydrochloride(Gemzar).html","C9H11F2N3O4.HCI","Hydrochloride","NSC 613327,LY-188011 HCl","Cl.NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2(F)F",-1.012,3,3,2]
["S1375","Dorzolamide HCl","e2","L6200-28","in 10mM Water","Carbonic Anhydrase","Metabolism","Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.",{"v":360.9,"d":"360.90"},"130693-82-2","<1","N/A",{"v":14,"d":"14.00"},38.79,"http://selleckchem.com/products/Dorzolamide-HCL.html","C10H16N2O4S3.HCl","Hydrochloride","MK-507 (L-671152) HCl","Cl.CCNC1CC(C)[S](=O)(=O)C2=C1C=C(S2)[S](N)(=O)=O",0.527,4,2,3]
["S1384","Mizoribine","f2","L6200-28","in 10mM Water","DNA/RNA Synthesis,HCV","DNA Damage/DNA Repair","Mizoribine (Bredinin, NSC 289637,HE 69) is an imidazole nucleoside and an immunosuppressant that inhibits HCV RNA replication with IC50 of ~ 100 μM for anti-HCV activity. Mizoribine is a selective inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase. Mizoribine also inhibits SARS-CoV.",259.22,"50924-49-7",{"v":1,"d":"1.00"},3.86,{"v":51,"d":"51.00"},196.74,"http://selleckchem.com/products/Mizoribine.html","C9H13N3O6","free base","Bredinin, NSC 289637,HE 69","NC(=O)C1=C(O)[N](C=N1)C2OC(CO)C(O)C2O",-2.409,3,5,3]
["S1494","Ralimetinib (LY2228820) dimesylate","g2","L6200-28","in 10mM Water","p38 MAPK","MAPK","Ralimetinib (LY2228820) dimesylate is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, does not alter p38 MAPK activation. Phase 1/2.",612.74,"862507-23-1",{"v":4,"d":"4.00"},6.53,{"v":100,"d":"100.00"},{"v":163.2,"d":"163.20"},"http://selleckchem.com/products/LY2228820.html","C24H29FN6.2CH4O3S","dimesylate","N/A","CC(C)(C)C[N]1C(=NC2=CC=C(N=C12)C3=C(N=C([NH]3)C(C)(C)C)C4=CC=C(F)C=C4)N.C[S;v6](O)(=O)=O",5.117,3,2,5]
["S1516","Cidofovir","h2","L6200-28","in 10mM Water","CMV,DNA/RNA Synthesis","DNA Damage/DNA Repair","Cidofovir (HPMPC,Vistide,GS 0504) suppresses virus replication by selective inhibition of viral DNA synthesis.",279.19,"113852-37-2",{"v":2,"d":"2.00"},7.16,{"v":12,"d":"12.00"},42.98,"http://selleckchem.com/products/Cidofovir.html","C8H14N3O6P","Free Base","HPMPC,Vistide,GS 0504","NC1=NC(=O)N(CC(CO)OC[P](O)(O)=O)C=C1",-2.175,3,2,6]
["S1518","Ibuprofen Lysine","a3","L6200-28","in 10mM Water","COX","Neuronal Signaling","Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.",352.47,"57469-77-9","<1","N/A",{"v":71,"d":"71.00"},201.44,"http://selleckchem.com/products/Ibuprofen-Lysine(Motrin).html","C19H32N2O4","Lysine","N/A","CC(C)CC1=CC=C(C=C1)C(C)C(O)=O.NCCCCC(N)C(O)=O",-2.112,2,2,9]
["S1579","Palbociclib (PD0332991) Isethionate","b3","L6200-28","in 10mM Water","CDK","Cell Cycle","Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.",573.66,"827022-33-3","<1","N/A",{"v":10,"d":"10.00"},17.43,"http://selleckchem.com/products/pd-0332991-palbociclib-isethionate.html","C24H29N7O2.C2H6O4S","Isethionate","N/A","CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O.OCC[S](O)(=O)=O",1.847,5,3,7]
["S1648","Cytarabine (U-19920A)","c3","L6200-28","in 10mM Water","Apoptosis related,Autophagy,DNA/RNA Synthesis,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Cytarabine (Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459,U-19920A) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.",243.22,"147-94-4",{"v":1,"d":"1.00"},4.11,{"v":48,"d":"48.00"},197.35,"http://selleckchem.com/products/Cytarabine(Cytosar-U).html","C9H13N3O5","free base","Cytarabin,Ara-C,Arabinofuranosyl Cytidine,Cytosine β-D-arabinofuranoside,Cytosine arabinoside,NSC 63878,NSC 287459,U-19920A","NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O",-2.396,3,4,2]
["S1893","D-glutamine","d3","L6200-28","in 10mM Water","GluR","Neuronal Signaling","D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.",146.14,"5959-95-5","<1","N/A",{"v":9,"d":"9.00"},61.58,"http://selleckchem.com/products/D-glutamine.html","C5H10N2O3","free base","N/A","NC(CCC(N)=O)C(O)=O",-4.087,2,2,4]
["S1985","ATP disodium","e3","L6200-28","in 10mM Water","Others","Others","ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.",551.14,"987-65-5","<1","N/A",{"v":100,"d":"100.00"},181.44,"http://selleckchem.com/products/atp-Adenosine-Triphosphate.html","C10H14N5O13P3.2Na","Disodium Salt","Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate","[Na+].[Na+].NC1=NC=NC2=C1N=C[N]2C3OC(CO[P](O)(=O)O[P]([O-])(=O)O[P](O)([O-])=O)C(O)C3O",-5.474,7,3,8]
["S1995","Procarbazine HCl","f3","L6200-28","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Procarbazine HCl (NSC-77213) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound, used for the treatment of Hodgkin's lymphoma.",257.76,"366-70-1","<1","N/A",{"v":52,"d":"52.00"},201.74,"http://selleckchem.com/products/procarbazine-hydrochloride-matulane.html","C12H19N3O.HCl","Hydrochloride","NSC-77213 HCl","Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C",{"v":1.12,"d":"1.120"},1,3,5]
["S1999","Sodium butyrate","g3","L6200-28","in 10mM Water","Apoptosis related,Autophagy,HDAC","Epigenetics","Sodium butyrate (NaB, Butanoic acid sodium salt), sodium salt of butyric acid, is a histone deacetylase inhibitor and competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). Sodium butyrate (NaB) inhibits cell cycle progression, promotes differentiation, and induces apoptosis and autophagy in several types of cancer cells.",110.09,"156-54-7","<1","N/A",{"v":22,"d":"22.00"},199.84,"http://selleckchem.com/products/Sodium-butyrate.html","C4H7NaO2","Sodium Salt","NaB, Butanoic acid sodium salt","[Na+].CCCC([O-])=O",-0.556,0,0,2]
["S2008","Taurine","h3","L6200-28","in 10mM Water","Others","Others","Taurine is an organic acid widely distributed in animal tissues.",125.15,"107-35-7","<1","N/A",{"v":20,"d":"20.00"},159.81,"http://selleckchem.com/products/Taurine.html","C2H7NO3S","free base","N/A","NCC[S](O)(=O)=O",-1.243,0,1,2]
["S2129","Fudosteine","a4","L6200-28","in 10mM Water","Others","Metabolism","Fudosteine is a cysteine derivative and a MUC5AC mucin hypersecretion inhibitor, used as a muco-active agent with indications for chronic respiratory diseases.",179.24,"13189-98-5","<1","N/A",{"v":36,"d":"36.00"},200.85,"http://selleckchem.com/products/Fudosteine.html","C6H13NO3S","free base","N/A","NC(CSCCCO)C(O)=O",-3.373,1,2,6]
["S2416","Chondroitin sulfate","b4","L6200-28","in 10mM Water","NF-κB","NF-κB","Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons. It reduces the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes in vitro.",489.45,"9007-28-7","N/A","N/A",{"v":97,"d":"97.00"},198.18,"http://selleckchem.com/products/chondroitin-sulfate.html","(C14H21NO14S)n","sulfate","N/A","COC1OC(CO[S](O)(=O)=O)C(O)C(OC2OC(C(C)C(O)C2O)C(O)=O)C1NC(C)=O",-2.447,7,4,8]
["S2420","Aloperine","c4","L6200-28","in 10mM Water","Antiviral,Bacterial","Microbiology","Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.",232.36,"56293-29-9",{"v":2,"d":"2.00"},8.61,{"v":12,"d":"12.00"},51.64,"http://selleckchem.com/products/aloperine.html","C15H24N2","Free Base","N/A","C1CCN2CC3CC(C=C4CCCNC34)C2C1",1.998,0,1,0]
["S2462","Donepezil HCl","d4","L6200-28","in 10mM Water","AChR","Neuronal Signaling","Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.",{"v":416,"d":"416.00"},"120011-70-3","<1","N/A",{"v":5,"d":"5.00"},12.02,"http://selleckchem.com/products/Donepezil-hydrochloride(Aricept).html","C24H29NO3.HCl","Hydrochloride","N/A","Cl.COC1=C(OC)C=C2C(=O)C(CC3CCN(CC3)CC4=CC=CC=C4)CC2=C1",4.951,3,0,6]
["S2507","Salbutamol Sulfate","e4","L6200-28","in 10mM Water","Adrenergic Receptor","Neuronal Signaling","Salbutamol Sulfate (Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.",337.39,"51022-70-9","<1","N/A",{"v":68,"d":"68.00"},201.55,"http://selleckchem.com/products/Salbutamol-sulfate(Albuterol).html","C13H21NO3.H2SO4","Sulfate","Albuterol, Ventolin, Aerolin, Ventorlin, Asthalin, Asthavent","CC(C)(C)NCC(O)C1=CC=C(O)C(=C1)CO.O[S](O)(=O)=O",0.334,0,4,5]
["S2877","L-NAME HCl","f4","L6200-28","in 10mM Water","NOS","Immunology & Inflammation","L-NAME HCl (NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester) is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.",269.69,"51298-62-5","<1","N/A",{"v":54,"d":"54.00"},200.23,"http://selleckchem.com/products/l-name-hcl.html","C7H15N5O4.HCl","Hydrochloride","NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester","Cl.COC(=O)C(N)CCCNC(=N)N[N+]([O-])=O",1.463,2,3,9]
["S3013","Plerixafor (AMD3100) 8HCl","g4","L6200-28","in 10mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.",794.47,"155148-31-5","<1","N/A",{"v":100,"d":"100.00"},125.87,"http://selleckchem.com/products/plerixafor-8hcl-db06809.html","C28H54N8.8HCl","Octahydrochloride","JM 3100 8HCl,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride","Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",2.536,0,6,4]
["S3056","Miltefosine","h4","L6200-28","in 10mM Water","Akt","PI3K/Akt/mTOR","Miltefosine (Hexadecylphosphocholine) inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.",407.57,"58066-85-6","<1","N/A",{"v":81,"d":"81.00"},198.74,"http://selleckchem.com/products/miltefosine-hexadecylphosphocholine.html","C21H46NO4P","free base","Hexadecylphosphocholine","CCCCCCCCCCCCCCCCO[P]([O-])(=O)OCC[N+](C)(C)C",3.722,2,0,20]
["S3174","L-Arginine HCl (L-Arg)","a5","L6200-28","in 10mM Water","NOS","Immunology & Inflammation","L-Arginine(L-Arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.",210.66,"1119-34-2","<1","N/A",{"v":42,"d":"42.00"},199.37,"http://selleckchem.com/products/l-Arginine-hydrochloride.html","C6H14N4O2.HCl","HCl","(S)-(+)-Arginine hydrochloride","Cl.NC(CCCNC(N)=N)C(O)=O",-3.449,1,3,6]
["S3620","β-Glycerophosphate sodium salt hydrate","b5","L6200-28","in 10mM Water","phosphatase","Metabolism","β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.",306.11,"13408-09-8","<1","N/A",{"v":61,"d":"61.00"},199.27,"http://selleckchem.com/products/beta-glycerophosphate-sodium-salt-hydrate.html","C3H9O6P.5H2O.2Na","sodium salt hydrate","N/A","O.O.O.O.O.OCC(CO)O[P](=O)(O[Na])O[Na]",-2.334,3,2,6]
["S3631","(S)-Methylisothiourea sulfate","c5","L6200-28","in 10mM Water","ROS","Immunology & Inflammation","(S)-Methylisothiourea sulfate is a potent inhibitor of inducible NO synthase (iNOS).",139.19,"867-44-7","<1","N/A",{"v":27,"d":"27.00"},193.98,"http://selleckchem.com/products/s-methylisothiourea-sulfate.html","C2H6N2S.1/2H2SO4","sulfate","N/A","CSC(N)=N",1.158,0,1,1]
["S3753","L-Leucine","d5","L6200-28","in 10mM Water","mTOR","PI3K/Akt/mTOR","Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing.  L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.",131.17,"61-90-5","<1","N/A",{"v":5,"d":"5.00"},38.12,"http://selleckchem.com/products/l-leucine.html","C6H13NO2","free base","(S)-Leucine, Leu","CC(C)CC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3793","Phytic acid","e5","L6200-28","in 10mM Water","Xanthine Oxidase","Metabolism","Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.",660.04,"83-86-3","<1","N/A",{"v":100,"d":"100.00"},151.51,"http://selleckchem.com/products/phytic-acid.html","C6H18O24P6","free base","Inositol polyphosphate, Inositol hexakisphosphate","O[P](O)(=O)OC1C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P](O)(O)=O)C1O[P](O)(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3852","L-Theanine","f5","L6200-28","in 10mM Water","Others","Others","L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis and is known to promote relaxation without sedation.",{"v":174.2,"d":"174.20"},"3081-61-6","<1","N/A",{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-theanine.html","C7H14N2O3","free base","N/A","CCNC(=O)CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3973","L-SelenoMethionine","g5","L6200-28","in 10mM Water","ROS","Immunology & Inflammation","L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.",196.11,"3211-76-5","<1","N/A",{"v":39,"d":"39.00"},198.87,"http://selleckchem.com/products/l-selenomethionine.html","C5H11NO2Se","free base","N/A","C[Se]CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S3989","L-​Histidine","h5","L6200-28","in 10mM Water","Others","Others","L-​Histidine (Glyoxaline-5-alanine) is an α-amino acid needed in humans for growth and tissue repair. It is used in the biosynthesis of proteins.",155.15,"71-00-1","<1","N/A",{"v":31,"d":"31.00"},199.81,"https://www.selleckchem.com/products/l-histidine.html","C6H9N3O2","free base","Glyoxaline-5-alanine","NC(CC1=C[NH]C=N1)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4028","Dexamethasone Sodium Phosphate","a6","L6200-28","in 10mM Water","Autophagy,Complement System,COVID-19,COX,IL Receptor","Immunology & Inflammation","Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator  that has anti-inflammatory and immunosuppressant effects.",{"v":516.4,"d":"516.40"},"55203-24-2","<1","N/A",{"v":103,"d":"103.00"},199.46,"http://selleckchem.com/products/dexamethasone-sodium-phosphate.html","C22H30FO8P.2Na","Disodium salt","Dexamethasone 21-phosphate disodium salt","[Na+].[Na+].CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO[P]([O-])([O-])=O",-0.541,3,1,4]
["S4029","Colistin Sulfate","b6","L6200-28","in 10mM Water","Bacterial","Microbiology","Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.",1400.63,"1264-72-8","<1","N/A",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},"http://selleckchem.com/products/colistin-sulfate.html","C52H98N16O13.5/2H2SO4","Sulfate","Polymixin E Sulfate","CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O.CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC2CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC2=O)C(C)O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O.O[S](O)(=O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4157","Chloroquine diphosphate","c6","L6200-28","in 10mM Water","Anti-infection,ATM/ATR,Autophagy,COVID-19,TLR","PI3K/Akt/mTOR","Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).",515.86,"50-63-5","<1","N/A",{"v":100,"d":"100.00"},193.85,"http://selleckchem.com/products/chloroquine-phosphate.html","C18H26ClN3.2H3O4P","diphosphate","N/A","CCN(CC)CCCC(C)NC1=CC=NC2=C1C=CC(=C2)Cl.O[P](O)(O)=O.O[P](O)(O)=O",3.408,1,1,8]
["S4180","Nefopam HCl","d6","L6200-28","in 10mM Water","Sodium Channel","Transmembrane Transporters","Nefopam HCl(Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.",{"v":289.8,"d":"289.80"},"23327-57-3",{"v":1,"d":"1.00"},3.45,{"v":21,"d":"21.00"},72.46,"http://selleckchem.com/products/nefopam-hcl.html","C17H19NO.HCl","Hydrochloride","Fenazoxine hydrochloride","Cl.CN1CCOC(C2=CC=CC=C2)C3=C(C1)C=CC=C3",{"v":3.52,"d":"3.520"},1,0,1]
["S4236","Proflavine Hemisulfate","e6","L6200-28","in 10mM Water","Anti-infection,DNA/RNA Synthesis","Microbiology","Proflavine Hemisulfate is a topical antiseptic by interchelating DNA, thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands.",258.25,"1811-28-5","<1","N/A",{"v":22,"d":"22.00"},85.19,"http://selleckchem.com/products/proflavine-hemisulfate.html","C13H11N3.1/2H2SO4","Sulfate","N/A","NC1=CC=C2C=C3C=CC(=CC3=NC2=C1)N.NC4=CC=C5C=C6C=CC(=CC6=NC5=C4)N.O[S](O)(=O)=O",3.113,2,4,0]
["S4245","Sodium ascorbate","f6","L6200-28","in 10mM Water","Vitamin","Metabolism","Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.",198.11,"134-03-2",{"v":2,"d":"2.00"},9.94,{"v":40,"d":"40.00"},198.88,"http://selleckchem.com/products/sodium-ascorbate.html","C6H7NaO6","Sodium Salt","Sodium Vitamin C","[NaH].OCC(O)C1OC(=O)C(O)C1O",-2.229,2,4,2]
["S4360","Tolmetin Sodium","g6","L6200-28","in 10mM Water","COX","Immunology & Inflammation","Tolmetin(MCN2559) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Tolmetin sodium dihydrate is a non-steroidal antiinflammatory agent, and acts as a non-selective COX inhibitor.",{"v":315.3,"d":"315.30"},"64490-92-2","<1",{"v":0,"d":"0.00"},{"v":63,"d":"63.00"},199.81,"http://www.selleckchem.com/products/tolmetin-sodium.html","C15H14NO3.Na.2H2O","sodium","MCN2559","O.O.C[N]1C(=CC=C1C(=O)C2=CC=C(C)C=C2)CC(=O)O[Na]",2.943,3,0,5]
["S4430","Hydroxychloroquine Sulfate (NSC 4375)","h6","L6200-28","in 10mM Water","Anti-infection,Autophagy,COVID-19,TLR","Autophagy","Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.",433.95,"747-36-4","<1","N/A",{"v":67,"d":"67.00"},{"v":154.4,"d":"154.40"},"http://selleckchem.com/products/hydroxychloroquine-sulfate.html","C18H28ClN3O5S","Sulfate","HCQ","CCN(CCO)CCCC(C)NC1=CC=NC2=CC(=CC=C12)Cl.O[S](O)(=O)=O",{"v":2.85,"d":"2.850"},1,2,9]
["S4606","Glutathione","a7","L6200-28","in 10mM Water","Glutathione","Metabolism","Glutathione (Isethion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.",307.32,"70-18-8","<1","N/A",{"v":61,"d":"61.00"},198.49,"http://selleckchem.com/products/glutathione.html","C10H17N3O6S","free base","Isethion, Glutathion, Tathion, L-Glutathione reduced, GSH; γ-L-Glutamyl-L-cysteinyl-glycine","NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O",-4.772,4,3,9]
["S4671","Cefradine","b7","L6200-28","in 10mM Water","Antibiotics","Microbiology","Cefradine (Cephradine, Sefril, Anspor, Velosef) is a semi-synthetic cephalosporin antibiotic.",{"v":349.4,"d":"349.40"},"38821-53-3","<1","N/A",{"v":10,"d":"10.00"},28.62,"http://selleckchem.com/products/cefradine.html","C16H19N3O4S","free base","Cephradine, Sefril, Anspor, Cephradin, Velosef","CC1=C(N2C(SC1)C(NC(=O)C(N)C3=CCC=CC3)C2=O)C(O)=O",-2.277,3,2,4]
["S4740","Sodium ferulate","c7","L6200-28","in 10mM Water","5-HT Receptor","Neuronal Signaling","Sodium ferulate (SF, Ferulic acid sodium salt), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.",216.17,"24276-84-4",{"v":2,"d":"2.00"},9.25,{"v":43,"d":"43.00"},198.92,"http://selleckchem.com/products/ferulic-acid-sodium.html","C10H9O4.Na","Sodium salt","Ferulic acid sodium salt","[Na+].COC1=CC(=CC=C1O)\\C=C\\C([O-])=O",0.195,1,1,3]
["S4741","Danshensu","d7","L6200-28","in 10mM Water","P450 (e.g. CYP17)","Metabolism","Danshensu (Salvianic acid A), a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and anti‑angiogenesis effects. Danshensu inhibits CYP2E1 and CYP2C9 with IC50 of 36.63 and 75.76 μm, respectively.",198.17,"76822-21-4","<1","N/A",{"v":23,"d":"23.00"},116.06,"http://selleckchem.com/products/danshensu.html","C9H10O5","free base","Salvianic acid A","OC(CC1=CC=C(O)C(=C1)O)C(O)=O",0.679,1,3,3]
["S4786","S-Methyl-L-cysteine","e7","L6200-28","in 10mM Water","Others","Others","S-Methyl-L-cysteine (S-Methylcysteine) is one of the identified number of bioactive substances in garlic that are water soluble that may exert some chemopreventive effects on chemical carcinogenesis.",135.18,"1187-84-4","<1","N/A",{"v":27,"d":"27.00"},199.73,"http://selleckchem.com/products/s-methyl-l-cysteine.html","C4H9NO2S","free base","S-Methylcysteine","CSCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4791","S-allyl-L-cysteine","f7","L6200-28","in 10mM Water","Others","Apoptosis","S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.",161.22,"21593-77-1","<1","N/A",{"v":32,"d":"32.00"},198.49,"http://selleckchem.com/products/s-allyl-l-cysteine.html","C6H11NO2S","free base","S-Allylcysteine","NC(CSCC=C)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S4993","Timonacic","g7","L6200-28","in 10mM Water","Others","Others","Timonacic (Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid) is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities.",133.17,"444-27-9",{"v":1,"d":"1.00"},7.51,{"v":27,"d":"27.00"},202.75,"http://www.selleckchem.com/products/timonacic.html","C4H7NO2S","Free Base","Thiazolidine-4-carboxylic acid, Detoxepa, Hepalidine, 1,3-Thiazolidine-4-carboxylic acid","OC(=O)C1CSCN1",-2.889,1,1,1]
["S5097","Methotrexate disodium","h7","L6200-28","in 10mM Water","Dehydrogenase,DHFR","Metabolism","Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.",{"v":498.4,"d":"498.40"},"7413-34-5","<1","N/A",{"v":99,"d":"99.00"},198.64,"http://selleckchem.com/products/methotrexate-disodium.html","C20H20N8O5.2Na","disodium salt","N/A","[Na+].[Na+].CN(CC1=NC2=C(N)N=C(N)N=C2N=C1)C3=CC=C(C=C3)C(=O)NC(CCC([O-])=O)C([O-])=O",-2.834,5,3,9]
["S5115","Sodium L-ascorbyl-2-phosphate","a8","L6200-28","in 10mM Water","c-Met","Protein Tyrosine Kinase","Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects.  Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective  antioxidant and a stimulator of hepatocyte growth factor (HGF) production.",322.05,"66170-10-3","<1","N/A",{"v":64,"d":"64.00"},198.73,"http://selleckchem.com/products/sodium-l-ascorbyl-2-phosphate.html","C6H6O9P.3Na","sodium salt","Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate","[Na+].[Na+].[Na+].OCC(O)C1OC(=O)C(=C1[O-])O[P]([O-])([O-])=O",{"v":-5.03,"d":"-5.030"},3,2,4]
["S5226","L-carnosine","b8","L6200-28","in 10mM Water","Others","Others","L-carnosine (Karnozin) is an antioxidant naturally found in skeletal muscle, brain tissue, and the heart that protects cells against oxidative stress.",226.23,"305-84-0","<1","N/A",{"v":45,"d":"45.00"},198.91,"http://selleckchem.com/products/l-carnosine.html","C9H14N4O3","free base","Karnozin","NCCC(=O)NC(CC1=C[NH]C=N1)C(O)=O",-4.268,3,3,6]
["S5374","5'-Cytidylic acid","c8","L6200-28","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","5'-Cytidylic acid (Cytidine monophosphate, Cytidine 5'-phosphate) is a nucleotide that is used as a monomer in RNA.",{"v":323.2,"d":"323.20"},"63-37-6","<1","N/A",{"v":64,"d":"64.00"},198.02,"http://selleckchem.com/products/5-cytidylic-acid.html","C9H14N3O8P","free base","Cytidine monophosphate, Cytidine 5'-phosphate","NC1=NC(=O)N(C=C1)C2OC(CO[P](O)(O)=O)C(O)C2O",-2.468,4,3,4]
["S5384","UTP Trisodium Salt","d8","L6200-28","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription.",550.09,"19817-92-6","<1","N/A",{"v":100,"d":"100.00"},181.79,"http://selleckchem.com/products/utp-trisodium-salt.html","C9H15N2O15P3.3Na","Trisodium salt","N/A","[Na+].[Na+].[Na+].OC1C(O)C(OC1CO[P]([O-])(=O)O[P]([O-])(=O)O[P](O)([O-])=O)N2C=CC(=O)NC2=O",-7.518,6,3,8]
["S5412","Loxoprofen Sodium","e8","L6200-28","in 10mM Water","Immunology & Inflammation related","Immunology & Inflammation","Loxoprofen sodium is a non-steroidal anti-inflammatory drug.",268.28,"80382-23-6","<1","N/A",{"v":53,"d":"53.00"},197.55,"https://www.selleckchem.com/products/loxoprofen-sodium.html","C15H17O3.Na","sodium salt","N/A","[Na+].CC(C([O-])=O)C1=CC=C(CC2CCCC2=O)C=C1",1.462,1,0,4]
["S5545","DL-Serine","f8","L6200-28","in 10mM Water","PKM","Metabolism","Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.",105.09,"302-84-1","<1","N/A",{"v":8,"d":"8.00"},76.13,"http://selleckchem.com/products/dl-serine.html","C3H7NO3","salt","N/A","NC(CO)C(O)=O",-4.049,1,2,2]
["S5584","Citronellol","g8","L6200-28","in 10mM Water","Apoptosis related,Caspase,RIP kinase,ROS,TNF-alpha","Apoptosis","Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. Citronellol also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.",156.27,"106-22-9","<1","N/A",{"v":31,"d":"31.00"},198.37,"http://selleckchem.com/products/citronellol.html","C10H20O","free base","Dihydrogeraniol, (±)-β-Citronellol","CC(CCO)CCC=C(C)C",3.049,0,1,5]
["S5633","L-methionine","h8","L6200-28","in 10mM Water","Others","Others","L-Methionine is an essential sulfur-containing, free-form amino acid, acts as an antioxidant promoter, and contributes to the synthesis of S-adenosyl-L-methionine (SAMe).",149.21,"63-68-3","<1","N/A",{"v":29,"d":"29.00"},194.36,"http://selleckchem.com/products/l-methionine.html","C5H11NO2S","free base","N/A","CSCCC(N)C(O)=O",-2.834,1,1,4]
["S5634","L-arginine","a9","L6200-28","in 10mM Water","Others","Others","Arginine is an important amino acid used in the biosynthesis of proteins. L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. It is also implicated in cell division, wound healing and the release of hormones.",{"v":174.2,"d":"174.20"},"74-79-3","<1","N/A",{"v":34,"d":"34.00"},195.18,"http://selleckchem.com/products/l-arginine.html","C6H14N4O2","free base","N/A","NC(CCCNC(N)=N)C(O)=O",-3.831,1,3,6]
["S6021","5-Methylcytosine","b9","L6200-28","in 10mM Water","Others","Others","5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription.",125.13,"554-01-8","N/A","N/A",{"v":8,"d":"8.00"},63.93,"http://www.selleck.cn/products/5-methylcytosine.html","C5H7N3O","free base","N/A","CC1=C(N)NC(=O)N=C1",-0.081,2,2,0]
["S6106","3-Chloro-L-tyrosine","c9","L6200-28","in 10mM Water","Peroxidases","Metabolism","3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.",215.63,"7423-93-0","N/A","N/A",{"v":9,"d":"9.00"},41.74,"http://www.selleck.cn/products/3-chloro-l-tyrosine.html","C9H10ClNO3","free base","N/A","NC(CC1=CC(=C(O)C=C1)Cl)C(O)=O",-1.183,1,2,3]
["S6201","Malachite green","d9","L6200-28","in 10mM Water","Others","Others","Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity.",{"v":927,"d":"927.00"},"2437-29-8","N/A","N/A",{"v":185.4,"d":"185.40"},{"v":200,"d":"200.00"},"http://www.selleck.cn/products/malachite-green.html","C52H54N4O12","free base","Aniline green, Basic green 4, Diamond green B, Victoria green B","CN(C)C1=CC=C(C=C1)C(C2=CC=CC=C2)=C3C=CC(C=C3)=[N+](C)C.CN(C)C4=CC=C(C=C4)C(C5=CC=CC=C5)=C6C=CC(C=C6)=[N+](C)C.OC(=O)C(O)=O.OC(=O)C([O-])=O.OC(=O)C([O-])=O",5.289,4,0,9]
["S6445","Chlorophyllin (sodium copper salt)","e9","L6200-28","in 10mM Water","Others","Others","Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent.",724.15,"11006-34-1","<1","N/A",{"v":13,"d":"13.00"},17.95,"http://www.selleck.cn/products/chlorophyllin.html","C34H31CuN4Na3O6","sodium copper salt","N/A","[Na+].[Na+].[Na+].[Cu++]|1|2|3|[N-]4C5=C(C)C(=C4C=C6N|1=C(C=C7[N-]|2C(=C(CC([O-])=O)C8=N|3C(=C5)C(C)C8CCC([O-])=O)C(=C7C)C([O-])=O)C(=C6C)CC)C=C",-1.452,0,0,8]
["S7204","Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium","f9","L6200-28","in 10mM Water","Apoptosis related,Microtubule Associated","Cytoskeletal Signaling","Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.",440.29,"168555-66-6","<1","N/A",{"v":28,"d":"28.00"},63.59,"http://selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html","C18H19O8P.2Na","Disodium salt","CA 4DP","[Na+].[Na+].COC1=C(O[P]([O-])([O-])=O)C=C(\\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1",1.077,5,0,8]
["S7306","Dorsomorphin (Compound C) 2HCl","g9","L6200-28","in 10mM Water","AMPK,Autophagy,TGF-beta/Smad","PI3K/Akt/mTOR","Dorsomorphin 2HCl (BML-275, Compound C) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line.",472.41,"1219168-18-9","<1","N/A",{"v":94,"d":"94.00"},198.98,"http://selleckchem.com/products/dorsomorphin-2hcl.html","C24H25N5O.2HCl","Dihydrochloride","BML-275 2HCl,Compound C 2HCl","Cl.Cl.C1CCN(CC1)CCOC2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC=C5",3.792,4,0,6]
["S7419","Blasticidin S HCl","h9","L6200-28","in 10mM Water","Antibiotics,DNA/RNA Synthesis,Selection Antibiotics for Transfected Cell","DNA Damage/DNA Repair","Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.",{"v":458.9,"d":"458.90"},"3513-03-9","<1","N/A",{"v":91,"d":"91.00"},{"v":198.3,"d":"198.30"},"http://selleckchem.com/products/blasticidin-s-hcl.html","C17H27ClN8O5","hydrochloride salt","N/A","Cl.CN(CCC(N)CC(=O)NC1C=CC(OC1C(O)=O)N2C=CC(=NC2=O)N)C(N)=N",-5.035,5,4,9]
["S7507","LDN-193189 2HCl","a10","L6200-28","in 10mM Water","TGF-beta/Smad","TGF-beta/Smad","LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.",{"v":479.4,"d":"479.40"},"1435934-00-1","<1","N/A",{"v":52,"d":"52.00"},108.47,"http://selleckchem.com/products/ldn-193189-2hcl.html","C25H24Cl2N6","Hydrochloride","DM-3189 2HCl","Cl.C1CN(CCN1)C2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC6=C5C=CC=C6",3.291,3,1,3]
["S7548","Rilmenidine Phosphate","b10","L6200-28","in 10mM Water","Imidazoline Receptor","GPCR & G Protein","Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used for the treatment of hypertension.",278.24,"85409-38-7",{"v":1,"d":"1.00"},3.59,{"v":55,"d":"55.00"},197.67,"http://selleckchem.com/products/rilmenidine-phosphate.html","C10H19N2O5P","Phosphate","N/A","O[P](O)(O)=O.C1CN=C(NC(C2CC2)C3CC3)O1",1.296,2,1,4]
["S7785","Pemetrexed Disodium Hydrate","c10","L6200-28","in 10mM Water","Apoptosis related,Autophagy,DHFR","Metabolism","Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.",516.42,"357166-30-4","<1","N/A",{"v":100,"d":"100.00"},193.64,"http://selleckchem.com/products/pemetrexed-disodium-hydrate.html","C20H21N5O6.5/2H2O.2Na","Disodium Hydrate","LY-231514 Disodium Hydrate","NC1=NC(=O)C2=C([NH]C=C2CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O[Na])C(=O)O[Na])N1",{"v":2.06,"d":"2.060"},7,4,11]
["S7873","Disodium (R)-2-Hydroxyglutarate","d10","L6200-28","in 10mM Water","ROS","Immunology & Inflammation","Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.",192.08,"103404-90-6","<1","N/A",{"v":38,"d":"38.00"},197.83,"http://selleckchem.com/products/disodium-r-2-hydroxyglutarate.html","C5H6Na2O5","disodium salt","D-α-Hydroxyglutaric acid disodium","OC(CCC(=O)O[Na])C(=O)O[Na]",-0.509,4,1,6]
["S7901","Ac-DEVD-CHO","e10","L6200-28","in 10mM Water","Caspase","Apoptosis","Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.",502.47,"169332-60-9","N/A","N/A",{"v":100,"d":"100.00"},199.02,"http://selleckchem.com/products/ac-devd-cho.html","C20H30N4O11","free base","Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO","CC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(=O)NC(CC(O)=O)C=O",{"v":-2.7,"d":"-2.700"},8,4,16]
["S8199","Ruxotemitide (LTX 315)","f10","L6200-28","in 10mM Water","Bcl-2","Apoptosis","Ruxotemitide (LTX 315, Oncopore) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.",1439.79,"1345407-05-7","N/A","N/A",{"v":100,"d":"100.00"},69.45,"http://selleckchem.com/products/ltx-315.html","C78H106N18O9","free base","Oncopore","NCCCCC(N)C(=O)NC(CCCCN)C(=O)NC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC3=C[NH]C4=C3C=CC=C4)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC5=C[NH]C6=C5C=CC=C6)C(=O)NC(C(C7=CC=CC=C7)C8=CC=CC=C8)C(=O)NC(CCCCN)C(N)=O",3.102,9,18,46]
["S8651","bpV (HOpic)","g10","L6200-28","in 10mM Water","PTEN","PI3K/Akt/mTOR","bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.",347.24,"722494-26-0","<1","N/A",{"v":69,"d":"69.00"},198.71,"http://selleckchem.com/products/bpv-hopic.html","C6H4NO8V.2K","potassium","Bisperoxovanadium (HOpic)","[K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O",-1.876,0,1,0]
["S9062","4-Hydroxyisoleucine","h10","L6200-28","in 10mM Water","Others","Others","4-Hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, has effects on the glucose and lipid metabolism, stimulates glucose-dependent insulin secretion and reduces insulin resistance in muscle and/or liver.",147.17,"781658-23-9",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":8.7,"d":"8.70"},59.11,"https://www.selleckchem.com/products/4-hydroxyisoleucine.html","C6H13NO3","free base","(2S, 3R)-2-Amino-4-hydroxy-3-methylpentanoic acid","CC(O)C(C)C(N)C(O)=O",-3.161,1,2,3]
["S9344","DL-Methionine","a11","L6200-28","in 10mM Water","Antiviral","Microbiology","DL-Methionine is an amino acid that has a role in the defence of oxidative stress.",149.21,"59-51-8","N/A",{"v":0,"d":"0.00"},{"v":6,"d":"6.00"},40.21,"https://www.selleckchem.com/products/dl-methionine.html","C5H11NO2S","free base","N/A","CSCCC(N)C(O)=O",-2.834,1,1,4]
["S3076","Foscarnet Sodium","b11","L6200-28","in 10mM Water","Reverse Transcriptase","Microbiology","Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.",191.95,"63585-09-1","N/A","N/A",{"v":3,"d":"3.00"},15.63,"http://selleckchem.com/products/foscarnet-sodium.html","CNa3O5P","Sodium","Phosphonoformate","[Na+].[Na+].[Na+].[O-]C(=O)[P]([O-])([O-])=O",-4.033,0,0,1]
["S2441","Estramustine phosphate sodium","c11","L6200-28","in 10mM Water","Microtubule Associated","Cytoskeletal Signaling","Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.",564.35,"52205-73-9","<1","N/A",{"v":100,"d":"100.00"},{"v":177.2,"d":"177.20"},"http://www.selleck.cn/products/estramustine-phosphate-sodium.html","C23H30Cl2NNa2O6P","phosphate sodium","EMP, Emcyt, Estracyt","[Na+].[Na+].CC12CCC3C(CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl)C1CCC2O[P]([O-])([O-])=O",3.131,3,0,8]
["S6077","Cytidine 5′-triphosphate (disodium salt)","d11","L6200-28","in 10mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases.",527.12,"36051-68-0","N/A","N/A","N/A",{"v":10,"d":"10.00"},"http://www.selleck.cn/products/cytidine-5-triphosphate-disodium-salt.html","C9H14N3Na2O14P3","disodium salt","N/A","[Na+].[Na+].NC1=NC(=O)N(C=C1)C2OC(CO[P](O)(=O)O[P]([O-])(=O)O[P](O)([O-])=O)C(O)C2O",-5.989,6,3,8]
["E2759","L-(+)-Ergothioneine","e11","L6200-28","in 10mM Water","Others","Others","L-(+)-Ergothioneine(Ergothioneine), an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.",{"v":229.3,"d":"229.30"},"497-30-3","<1","N/A",{"v":46,"d":"46.00"},200.61,"https://www.selleckchem.com/products/l--ergothioneine.html","C9H15N3O2S","Free base","Ergothioneine","C[N+](C)(C)C(CC1=CNC(=S)N1)C([O-])=O",-2.967,0,2,4]
["E1689","NADPH tetrasodium salt","f11","L6200-28","in 10mM Water","Others","Others","NADPH tetrasodium salt is a ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It plays a crucial role as a cofactor in the biosynthesis of nucleotides, proteins, and fatty acids. It is essential for neutralizing elevated levels of reactive oxygen species (ROS) generated by increased metabolic activity.",837.38,"2646-71-1","<1","N/A",{"v":100,"d":"100.00"},119.42,"https://www.selleckchem.com/products/nadph-tetrasodium-salt.html","C21H30N7O17P3.4Na","Tetrasodium","N/A","[NaH].NC(=O)C1=CN(C=CC1)C2OC(CO[P](O)(=O)O[P](O)(=O)OCC3OC(C(O[P](O)(O)=O)C3O)[N]4C=NC5=C(N)N=CN=C45)C(O)C2O",-4.131,10,5,13]
["S2542","Phenformin (NSC-756501) HCl","g11","L6200-28","in 10mM Water","AMPK","PI3K/Akt/mTOR","Phenformin HCl (NSC-756501, Phenethylbiguanide) is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.",241.72,"834-28-6","N/A","N/A","N/A",">10","http://selleckchem.com/products/Phenformin-hydrochloride.html","C10H15N5.HCl","Hydrochloride","Phenethylbiguanide HCl","Cl.NC(=N)NC(=N)NCCC1=CC=CC=C1",1.339,0,3,6]
["S1023","Erlotinib (OSI-774) HCl","a2","L6200-29","in 2mM DMSO","Autophagy,EGFR","Protein Tyrosine Kinase","Erlotinib (OSI-774, CP358774, NSC 718781) HCl is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.",{"v":429.9,"d":"429.90"},"183319-69-9",{"v":4,"d":"4.00"},{"v":9.3,"d":"9.30"},"<1","N/A","http://selleckchem.com/products/Erlotinib-Hydrochloride.html","C22H23N3O4.HCl","Hydrochloride","CP358774, NSC 718781,OSI-774 HCl","Cl.COCCOC1=C(OCCOC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C#C",4.691,6,1,10]
["S1046","Vandetanib (ZD6474)","b2","L6200-29","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1118","XL147 analogue","c2","L6200-29","in 2mM DMSO","Apoptosis related,PI3K","PI3K/Akt/mTOR","XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2.",448.52,"956958-53-5",{"v":3,"d":"3.00"},6.69,"<1","N/A","http://selleckchem.com/products/XL147.html","C21H16N6O2S2","Free Base","SAR245408","CC1=CC=C(C=C1)[S](=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4",5.024,6,2,5]
["S1205","PIK-75 HCl","d2","L6200-29","in 2mM DMSO","DNA-PK,PI3K","PI3K/Akt/mTOR","PIK-75 HCl is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.",488.74,"372196-77-5",{"v":4,"d":"4.00"},8.18,"<1","N/A","http://selleckchem.com/products/PIK-75-Hydrochloride.html","C16H14BrN5O4S.HCl","Hydrochloride","N/A","Cl.CN(/N=C/C1=CN=C2C=CC(=C[N]12)Br)[S](=O)(=O)C3=C(C)C=CC(=C3)[N+]([O-])=O",3.272,4,0,5]
["S1211","Imiquimod (R-837)","e2","L6200-29","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Imiquimod (Aldara,R-837,S-26308) is a novel synthetic agent with immune response modifying activity.",{"v":240.3,"d":"240.30"},"99011-02-6",{"v":1,"d":"1.00"},4.16,"<1","N/A","http://selleckchem.com/products/Imiquimod.html","C14H16N4","free base","Aldara,R-837, S-26308","CC(C)C[N]1C=NC2=C(N)N=C3C=CC=CC3=C12",2.722,2,1,2]
["S1288","Camptothecin (NSC-100880)","f2","L6200-29","in 2mM DMSO","ADC Cytotoxin,Apoptosis related,MicroRNA,Topoisomerase","DNA Damage/DNA Repair","Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.",348.35,"7689-03-4",{"v":3,"d":"3.00"},8.61,"<1","N/A","http://selleckchem.com/products/Camptothecine.html","C20H16N2O4","Free Base","CPT, Campathecin, (S)-(+)-Camptothecin","CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=CC5=C4)C2=O",1.746,4,0,1]
["S1327","Ellagic acid","g2","L6200-29","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property.",302.19,"476-66-4",{"v":3,"d":"3.00"},9.93,"<1","N/A","http://selleckchem.com/products/Ellagic-acid.html","C14H6O8","free base","Elagostasine, Gallogen","OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",{"v":0,"d":"0.000"},0,0,0]
["S1353","Ketoconazole (R 41400)","h2","L6200-29","in 2mM DMSO","Androgen Receptor,Fungal,P450 (e.g. CYP17)","Metabolism","Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.",531.43,"65277-42-1",{"v":5,"d":"5.00"},9.41,"<1","N/A","http://selleckchem.com/products/Ketoconazole.html","C26H28Cl2N4O4","free base","R 41400","CC(=O)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=CN=C4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",{"v":3.61,"d":"3.610"},5,0,7]
["S1360","GSK1059615","a3","L6200-29","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Phase 1.",333.36,"958852-01-2",{"v":2,"d":"2.00"},{"v":6,"d":"6.00"},"<1","N/A","http://selleckchem.com/products/GSK1059615.html","C18H11N3O2S","Free Base","N/A","O=C1NC(=O)/C(S1)=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2",2.496,4,1,2]
["S1424","Prazosin HCl","b3","L6200-29","in 2mM DMSO","Adrenergic Receptor","GPCR & G Protein","Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.",419.86,"19237-84-4",{"v":4,"d":"4.00"},9.53,"<1","N/A","http://selleckchem.com/products/Prazosin-hydrochloride.html","C19H21N5O4.HCl","Hydrochloride","cp-12299-1","Cl.COC1=CC2=C(C=C1OC)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N",2.489,6,1,4]
["S1464","Marbofloxacin","c3","L6200-29","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.",362.36,"115550-35-1",{"v":3,"d":"3.00"},8.28,"<1","N/A","http://selleckchem.com/products/Marbofloxacin.html","C17H19FN4O4","free base","N/A","CN1CCN(CC1)C2=C(F)C=C3C(=O)C(=CN4N(C)COC2=C34)C(O)=O",-2.038,3,0,2]
["S1509","Norfloxacin","d3","L6200-29","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Norfloxacin (MK-0366) is a broad-spectrum antibiotic. Norfloxacin (MK-0366) targets bacterial gyrase and topoisomerase IV enzymes.",319.33,"70458-96-7",{"v":3,"d":"3.00"},9.39,"<1","N/A","http://selleckchem.com/products/Norfloxacin(Norxacin).html","C16H18FN3O3","free base","MK-0366","CCN1C=C(C(O)=O)C(=O)C2=CC(=C(C=C12)N3CCNCC3)F",{"v":0,"d":"0.000"},0,0,0]
["S1519","CCT129202","e3","L6200-29","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.",497.02,"942947-93-5",{"v":3,"d":"3.00"},6.04,"<1","N/A","http://selleckchem.com/products/CCT129202.html","C23H25ClN8OS","Free Base","N/A","CN(C)C1=CC=C(C=C1)C2=NC3=C(N4CCN(CC4)CC(=O)NC5=NC=CS5)C(=CN=C3[NH]2)Cl",2.898,4,2,6]
["S1724","Paliperidone","f3","L6200-29","in 2mM DMSO","Dopamine Receptor","Neuronal Signaling","Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.",426.48,"144598-75-4",{"v":4,"d":"4.00"},9.38,"<1","N/A","http://selleckchem.com/products/Paliperidone(Invega).html","C23H27FN4O3","free base","N/A","CC1=C(CCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)C(=O)N5CCCC(O)C5=N1",{"v":0,"d":"0.000"},0,0,0]
["S1837","Flubendazole","g3","L6200-29","in 2mM DMSO","Autophagy,Parasite","Autophagy","Flubendazole (Flumoxanal, NSC 313680) is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.",313.28,"31430-15-6",{"v":3,"d":"3.00"},9.58,"<1","N/A","http://selleckchem.com/products/flubendazole-flutelmium.html","C16H12FN3O3","free base","Flumoxanal, NSC 313680","COC(=O)NC1=NC2=C([NH]1)C=C(C=C2)C(=O)C3=CC=C(F)C=C3",{"v":3.26,"d":"3.260"},4,2,4]
["S2047","Lornoxicam","h3","L6200-29","in 2mM DMSO","COX","Neuronal Signaling","Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.",371.82,"70374-39-9",{"v":3,"d":"3.00"},8.07,"<1","N/A","http://selleckchem.com/products/lornoxicam-xefo.html","C13H10ClN3O4S2","free base","Chlortenoxicam","CN1C(=C(O)C2=C(C=C(Cl)S2)[S]1(=O)=O)C(=O)NC3=NC=CC=C3",0.913,4,2,2]
["S2110","Vinpocetine","a4","L6200-29","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","Vinpocetine (RGH-4405,Ethyl apovincaminate,AY 27255) is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia  and Alzheimer's disease.",350.45,"42971-09-5",{"v":3,"d":"3.00"},8.56,"<1","N/A","http://selleckchem.com/products/vinpocetine-cavinton.html","C22H26N2O2","free base","RGH-4405,Ethyl apovincaminate,AY 27255","CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)[N]1C5=CC=CC=C45",{"v":0,"d":"0.000"},0,0,0]
["S2157","Taladegib (LY2940680)","b4","L6200-29","in 2mM DMSO","Hedgehog/Smoothened","Stem Cells & Wnt","Taladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. Phase 1/2.",{"v":512.5,"d":"512.50"},"1258861-20-9",{"v":5,"d":"5.00"},9.76,"<1","N/A","http://selleckchem.com/products/ly2940680.html","C26H24F4N6O","free base","N/A","C[N]1N=CC=C1C2=NN=C(N3CCC(CC3)N(C)C(=O)C4=C(C=C(F)C=C4)C(F)(F)F)C5=C2C=CC=C5",{"v":0,"d":"0.000"},0,0,0]
["S2232","Ketanserin","c4","L6200-29","in 2mM DMSO","5-HT Receptor","Neuronal Signaling","Ketanserin (R41468, Ketanserinum) is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.",395.43,"74050-98-9",{"v":2,"d":"2.00"},5.06,"<1","N/A","http://selleckchem.com/products/Ketanserin-Vulketan-Gel.html","C22H22FN3O3","Free Base","R41468, Ketanserinum","FC1=CC=C(C=C1)C(=O)C2CCN(CC2)CCN3C(=O)NC4=CC=CC=C4C3=O",2.991,3,1,5]
["S2251","(-)-Huperzine A (HupA)","d4","L6200-29","in 2mM DMSO","AChR,GluR","Neuronal Signaling","(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.",242.32,"102518-79-6",0.66,2.72,"<1","N/A","http://selleckchem.com/products/(-)-Huperzine-A.html","C15H18N2O","Free Base","N/A","C\\C=C/1C2CC3=C(C=CC(=O)N3)C1(N)CC(=C2)C",1.056,1,2,0]
["S2476","Itraconazole (R 51211)","e4","L6200-29","in 2mM DMSO","Autophagy,Fungal,Hedgehog/Smoothened,P450 (e.g. CYP17)","Stem Cells & Wnt","Itraconazole (R 51211) is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.",705.65,"84625-61-6",{"v":7,"d":"7.00"},9.92,"<1","N/A","http://selleckchem.com/products/Itraconazole(Sporanox).html","C35H38Cl2N8O4","free base","R 51211","CCC(C)N1N=CN(C1=O)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OCC5COC(C[N]6C=NC=N6)(O5)C7=CC=C(Cl)C=C7Cl)C=C4",6.434,7,0,11]
["S2628","Gedatolisib (PKI-587)","f4","L6200-29","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.",615.73,"1197160-78-3",{"v":2,"d":"2.00"},3.25,"<1","N/A","http://selleckchem.com/products/pki587.html","C32H41N9O4","Free Base","PF-05212384","CN(C)C1CCN(CC1)C(=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C=C2",2.525,7,2,7]
["S2638","NU7441 (KU-57788)","g4","L6200-29","in 2mM DMSO","CRISPR/Cas9,DNA-PK,mTOR,PI3K","DNA Damage/DNA Repair","NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage.",413.49,"503468-95-9",{"v":4,"d":"4.00"},9.67,"<1","N/A","http://selleckchem.com/products/nu7441.html","C25H19NO3S","free base","N/A","O=C1C=C(OC2=C1C=CC=C2C3=CC=CC4=C3SC5=C4C=CC=C5)N6CCOCC6",5.403,3,0,2]
["S2684","Pidnarulex (CX-5461)","h4","L6200-29","in 2mM DMSO","DNA/RNA Synthesis","DNA Damage/DNA Repair","Pidnarulex (CX-5461) is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.",513.61,"1138549-36-6",{"v":2,"d":"2.00"},3.89,"<1","N/A","http://www.selleck.cn/products/cx-5461.html","C27H27N7O2S","Free Base","N/A","CN1CCCN(CC1)C2=CC=C3C(=O)C(=C4SC5=C(C=CC=C5)N4C3=N2)C(=O)NCC6=CN=C(C)C=N6",3.188,5,1,4]
["S2704","LY2109761","a5","L6200-29","in 2mM DMSO","Apoptosis related,Autophagy,TGF-beta/Smad","TGF-beta/Smad","LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.",441.52,"700874-71-1",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/ly2109761.html","C26H27N5O2","Free Base","N/A","C1C[N]2N=C(C3=NC=CC=C3)C(=C2C1)C4=CC=NC5=C4C=CC(=C5)OCCN6CCOCC6",{"v":3.62,"d":"3.620"},5,0,6]
["S2735","MK-8776 (SCH 900776)","b5","L6200-29","in 2mM DMSO","CDK,Chk","Cell Cycle","MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.",376.25,"891494-63-6",{"v":3,"d":"3.00"},7.97,"<1","N/A","http://selleckchem.com/products/sch-900776.html","C15H18BrN7","Free Base","N/A","C[N]1C=C(C=N1)C2=C3N=C(C4CCCNC4)C(=C(N)[N]3N=C2)Br",{"v":1.32,"d":"1.320"},3,2,2]
["S2744","CCT137690","c5","L6200-29","in 2mM DMSO","Aurora Kinase","Cell Cycle","CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.",551.48,"1095382-05-0",{"v":4,"d":"4.00"},7.25,"<1","N/A","http://selleckchem.com/products/cct137690.html","C26H31BrN8O","Free Base","N/A","CN1CCN(CC1)C2=CC=C(C=C2)C3=NC4=C(N5CCN(CC5)CC6=NOC(=C6)C)C(=CN=C4[NH]3)Br",3.704,4,1,5]
["S2805","LY364947","d5","L6200-29","in 2mM DMSO","Casein Kinase,Mixed Lineage Kinase,RIP kinase,TGF-beta/Smad","TGF-beta/Smad","LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.",{"v":272.3,"d":"272.30"},"396129-53-6",{"v":1,"d":"1.00"},3.67,"<1","N/A","http://selleckchem.com/products/ly364947.html","C17H12N4","Free Base","HTS 466284","[NH]1C=C(C2=C3C=CC=CC3=NC=C2)C(=N1)C4=NC=CC=C4",3.203,3,1,2]
["S2827","Torin 1","e5","L6200-29","in 2mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.",607.62,"1222998-36-8",{"v":2,"d":"2.00"},3.29,"<1","N/A","http://selleckchem.com/products/torin-1.html","C35H28F3N5O2","Free Base","N/A","CCC(=O)N1CCN(CC1)C2=CC=C(C=C2C(F)(F)F)N3C(=O)C=CC4=C3C5=CC(=CC=C5N=C4)C6=CC7=CC=CC=C7N=C6",5.914,4,0,5]
["S2870","TG100713","f5","L6200-29","in 2mM DMSO","PI3K","PI3K/Akt/mTOR","TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.",254.25,"925705-73-3",{"v":2,"d":"2.00"},7.87,"<1","N/A","http://selleckchem.com/products/tg-100713.html","C12H10N6","Free Base","N/A","NC1=NC(=C2N=C(C=NC2=N1)C3=CC(=CC=C3)O)N",0.982,4,3,1]
["S2893","NU7026","g5","L6200-29","in 2mM DMSO","Apoptosis related,DNA-PK,PI3K","DNA Damage/DNA Repair","NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.",281.31,"154447-35-5",{"v":1,"d":"1.00"},3.55,"<1","N/A","http://selleckchem.com/products/nu7026.html","C17H15NO3","Free Base","LY293646","O=C1C=C(OC2=C1C=CC3=C2C=CC=C3)N4CCOCC4",2.732,3,0,1]
["S3042","Purmorphamine","h5","L6200-29","in 2mM DMSO","Autophagy,Hedgehog/Smoothened","Stem Cells & Wnt","Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.",520.62,"483367-10-8",{"v":4,"d":"4.00"},7.68,"<1","N/A","http://selleckchem.com/products/purmorphamine.html","C31H32N6O2","Free Base","Shh Signaling Antagonist VI","C1CCC(CC1)[N]2C=NC3=C2N=C(OC4=C5C=CC=CC5=CC=C4)N=C3NC6=CC=C(C=C6)N7CCOCC7",6.758,5,1,6]
["S3064","Ambroxol HCl","a6","L6200-29","in 2mM DMSO","Sodium Channel","Transmembrane Transporters","AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.",414.56,"23828-92-4",{"v":4,"d":"4.00"},9.65,"<1","N/A","http://selleckchem.com/products/ambroxol-hcl.html","C13H18Br2N2O.HCl","Hydrochloride","N/A","Cl.NC1=C(Br)C=C(Br)C=C1CNC2CCC(O)CC2",3.121,0,3,3]
["S3614","Lupeol","b6","L6200-29","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Lupeol (Clerodol, Monogynol B, Fagarasterol, Farganasterol) is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.",426.72,"545-47-1",{"v":1,"d":"1.00"},2.34,"<1","N/A","http://selleckchem.com/products/lupeol.html","C30H50O","free base","(3β,13ξ)-Lup-20(29)-en-3-ol, Clerodol, Monogynol B, Fagarasterol, Farganasterol","CC(=C)C1CCC2(C)CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C12",7.403,0,1,1]
["S3770","Sodium Aescinate","c6","L6200-29","in 2mM DMSO","NF-κB","NF-κB","Sodium Aescinate (SA, Escin Sodium Salt) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic.  Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.",1123.21,"20977-05-3",{"v":10,"d":"10.00"},{"v":8.9,"d":"8.90"},"N/A","N/A","http://selleckchem.com/products/sodium-aescinate.html","C54H83NaO23","sodium salt","Escin sodium salt","CC(OC(C)=O)C(C)C(=O)OCC12C(O)C3OC1CC4(C)C(=CCC5C6(C)CCC(OC7OC(C(OC8OC(CO)C(O)C(O)C8O)C(O)C7OC9OCC(O)C(O)C9O)C(=O)O[Na])C(C)(CO)C6CCC45C)C2CC3(C)C",-0.485,13,10,17]
["S3891","Vincamine","d6","L6200-29","in 2mM DMSO","Others","Others","Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.",354.44,"1617-90-9",{"v":3,"d":"3.00"},8.46,"N/A","N/A","http://selleckchem.com/products/vincamine.html","C21H26N2O3","free base","Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan","CCC12CCCN3CCC4=C(C13)[N](C5=CC=CC=C45)C(O)(C2)C(=O)OC",3.546,2,0,3]
["S4605","Folic acid","e6","L6200-29","in 2mM DMSO","Vitamin","Metabolism","Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.",{"v":441.4,"d":"441.40"},"59-30-3",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/folic-acid.html","C19H19N7O6","free base","Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate","NC1=NC(=O)C2=C(N1)N=CC(=N2)CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",-0.232,7,4,9]
["S4930","Cetilistat","f6","L6200-29","in 2mM DMSO","Lipase","Metabolism","Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo",401.58,"282526-98-1",{"v":3,"d":"3.00"},7.47,"<1","N/A","http://selleckchem.com/products/cetilistat.html","C25H39NO3","free base","ATL962","CCCCCCCCCCCCCCCCOC1=NC2=C(C=C(C)C=C2)C(=O)O1",9.409,4,0,16]
["S5116","Bilibubin","g6","L6200-29","in 2mM DMSO","Others","Others","Bilibubin (Bilirubin) is a tetrapyrrole and a breakdown product of heme catabolism that acts as a physiological, chain-breaking antioxidant.",584.66,"635-65-4",{"v":3,"d":"3.00"},5.13,"N/A","N/A","http://selleckchem.com/products/bilibubin.html","C33H36N4O6","free base","Bilirubin","CC1=C(C=C)/C(NC1=O)=C/C2=C(C)C(=C(CC3=C(CCC(O)=O)C(=C([NH]3)\\C=C\\4NC(=O)C(=C4C)C=C)C)[NH]2)CCC(O)=O",5.055,4,4,12]
["S5516","Ellagic Acid hydrate","h6","L6200-29","in 2mM DMSO","Casein Kinase","Metabolism","Ellagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties.",320.21,"314041-08-2",{"v":2,"d":"2.00"},6.25,"N/A","N/A","http://selleckchem.com/products/ellagic-acid-hydrate.html","C14H6O8.H2O","monohydrate","N/A","O.OC1=CC2=C3C(=C1O)OC(=O)C4=CC(=C(O)C(=C34)OC2=O)O",1.377,4,4,0]
["S5577","6-Biopterin","a7","L6200-29","in 2mM DMSO","NOS","Immunology & Inflammation","6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.",237.22,"22150-76-1",{"v":1,"d":"1.00"},4.22,"<1","N/A","https://www.selleckchem.com/products/6-biopterin.html","C9H11N5O3","free base","L-Biopterin, L-Erythro-Biopterin","CC(O)C(O)C1=NC2=C(NC(=NC2=O)N)N=C1",-1.131,4,4,2]
["S5611","2-cyano-Pyrimidine","b7","L6200-29","in 2mM DMSO","Cysteine Protease","Proteases","2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM.",{"v":105.1,"d":"105.10"},"14080-23-0",{"v":1,"d":"1.00"},9.51,{"v":1,"d":"1.00"},9.51,"http://www.selleckchem.com/products/2-cyano-pyrimidine.html","C5H3N3","Free Base","N/A","N#CC1=NC=CC=N1",0.031,2,0,0]
["S5677","Xanthopterin Hydrate","c7","L6200-29","in 2mM DMSO","Others","Others","Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species.",197.15,"5979-01-1",{"v":1,"d":"1.00"},5.07,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/xanthopterin-hydrate.html","C6H7N5O3","Hydrate","N/A","O.NC1=NC(=C2N=C(O)C=NC2=N1)O",-0.128,4,3,0]
["S5712","Zofenopril calcium","d7","L6200-29","in 2mM DMSO","RAAS","Endocrinology & Hormones","Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure.",897.17,"81938-43-4","N/A",{"v":2,"d":"2.00"},"<1","N/A","http://selleckchem.com/products/zofenopril-calcium.html","C44H44CaN2O8S4","calcium salt","SQ-26991","CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)O[Ca]OC(=O)C3CC(CN3C(=O)C(C)CSC(=O)C4=CC=CC=C4)SC5=CC=CC=C5)SC6=CC=CC=C6",8.055,8,0,20]
["S5902","1,2,3,4,5,6-Hexabromocyclohexane","e7","L6200-29","in 2mM DMSO","JAK","JAK/STAT","1,2,3,4,5,6-Hexabromocyclohexane (NSC7908) is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation with IC50 value to be estimated in low micromolar range.",557.54,"1837-91-8",{"v":5,"d":"5.00"},8.97,"<1","N/A","http://www.selleckchem.com/products/hexabromocyclohexane.html","C6H6Br6","Free Base","NSC7908","BrC1C(Br)C(Br)C(Br)C(Br)C1Br",{"v":5.03,"d":"5.030"},0,0,0]
["S6606","CDD3505","f7","L6200-29","in 2mM DMSO","P450 (e.g. CYP17)","Metabolism","CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.",355.39,"173865-33-3",{"v":2,"d":"2.00"},5.63,"<1","N/A","http://www.selleck.cn/products/cdd3505.html","C22H17N3O2","Free Base","N/A","[O-][N+](=O)C1=C[N](C=N1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4",4.991,1,0,5]
["S6642","Branaplam (LMI070)","g7","L6200-29","in 2mM DMSO","SMN","DNA Damage/DNA Repair","Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM.",393.48,"1562338-42-4",{"v":3,"d":"3.00"},7.62,"<1","N/A","http://www.selleck.cn/products/branaplam-lmi070.html","C22H27N5O2","Free Base","N/A","CC1(C)CC(CC(C)(C)N1)OC2=NN=C(C=C2)C3=C(O)C=C(C=C3)C4=C[NH]N=C4",3.141,4,3,4]
["S7004","EPZ005687","h7","L6200-29","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.",539.67,"1396772-26-1",{"v":2,"d":"2.00"},3.71,"<1","N/A","http://selleckchem.com/products/epz005687.html","C32H37N5O3","Free Base","N/A","CC1=CC(=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C4CCCC4)C5=CC=C(CN6CCOCC6)C=C5)C(=O)N1)C",3.919,4,2,7]
["S7035","XL388","a8","L6200-29","in 2mM DMSO","mTOR","PI3K/Akt/mTOR","XL388 is a highly potent, selective, ATP-competitive inhibitor of  mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.",{"v":455.5,"d":"455.50"},"1251156-08-7",1.25,2.74,"<1","N/A","http://selleckchem.com/products/xl388.html","C23H22FN3O4S","free base","N/A","CC1=C(F)C(=CC=C1C(=O)N2CCOC3=CC=C(C=C3C2)C4=CN=C(N)C=C4)[S](C)(=O)=O",3.007,5,1,3]
["S7061","GSK126","b8","L6200-29","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases.",526.67,"1346574-57-9",{"v":3,"d":"3.00"},{"v":5.7,"d":"5.70"},"<1","N/A","http://selleckchem.com/products/gsk126.html","C31H38N6O2","Free Base","GSK2816126A, GSK2816126","CCC(C)[N]1C=C(C)C2=C(C=C(C=C12)C3=CC=C(N=C3)N4CCNCC4)C(=O)NCC5=C(C)C=C(C)NC5=O",4.114,3,3,7]
["S7085","IWP-2","c8","L6200-29","in 2mM DMSO","Casein Kinase,Wnt/beta-catenin","Stem Cells & Wnt","IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.",{"v":466.6,"d":"466.60"},"686770-61-6",{"v":4,"d":"4.00"},8.57,"<1","N/A","http://selleckchem.com/products/iwp-2.html","C22H18N4O2S3","Free Base","N/A","CC1=CC2=C(C=C1)N=C(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3C5=CC=CC=C5)S2",4.277,4,1,5]
["S7128","Tazemetostat (EPZ-6438)","d8","L6200-29","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.",572.74,"1403254-99-8",{"v":5,"d":"5.00"},8.73,"<1","N/A","http://selleckchem.com/products/epz-6438.html","C34H44N4O4","free base","E7438","CCN(C1CCOCC1)C2=C(C)C(=CC(=C2)C3=CC=C(CN4CCOCC4)C=C3)C(=O)NCC5=C(C)C=C(C)NC5=O",3.506,4,2,9]
["S7164","GSK343","e8","L6200-29","in 2mM DMSO","Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. GSK343 induces autophagy.",541.69,"1346704-33-3",{"v":2,"d":"2.00"},3.69,"<1","N/A","http://www.selleck.cn/products/gsk343.html","C31H39N7O2","Free Base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC(=NC=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.902,4,2,8]
["S7400","ISRIB (trans-isomer)","f8","L6200-29","in 2mM DMSO","PERK","Apoptosis","ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.",451.34,"1597403-47-8",{"v":4,"d":"4.00"},8.86,"<1","N/A","http://selleckchem.com/products/isrib-trans-isomer.html","C22H24Cl2N2O4","Free Base","N/A","ClC1=CC=C(OCC(=O)NC2CCC(CC2)NC(=O)COC3=CC=C(Cl)C=C3)C=C1",4.055,4,2,8]
["S7518","Voreloxin (SNS-595) hydrochloride","g8","L6200-29","in 2mM DMSO","Topoisomerase","DNA Damage/DNA Repair","Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.",{"v":437.9,"d":"437.90"},"175519-16-1",{"v":1,"d":"1.00"},2.28,{"v":1,"d":"1.00"},2.28,"http://selleckchem.com/products/voreloxin-sns-595.html","C18H20ClN5O4S","hydrochloride","Vosaroxin","Cl.CNC1CN(CC1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(O)=O",-1.138,5,1,5]
["S7698","LY2584702","h8","L6200-29","in 2mM DMSO","S6 Kinase","PI3K/Akt/mTOR","LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.",445.42,"1082949-67-4",{"v":1,"d":"1.00"},2.25,"<1","N/A","http://selleckchem.com/products/ly2584702.html","C21H19F4N7","Free Base","N/A","C[N]1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=N[NH]4)C5=CC=C(F)C(=C5)C(F)(F)F",{"v":4.18,"d":"4.180"},4,1,4]
["S7840","Dorsomorphin (Compound C)","a9","L6200-29","in 2mM DMSO","AMPK,Autophagy,TGF-beta/Smad","PI3K/Akt/mTOR","Dorsomorphin (Compound C, BML-275) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble <a target='_blank' href='https://www.selleckchem.com/products/dorsomorphin-2hcl.html'>S7306 Dorsomorphin (Compound C) 2HCl</a> is recommended.",399.49,"866405-64-3",{"v":1,"d":"1.00"},{"v":2.5,"d":"2.50"},"<1","N/A","http://selleckchem.com/products/dorsomorphin.html","C24H25N5O","Free Base","BML-275,Compound C","C1CCN(CC1)CCOC2=CC=C(C=C2)C3=C[N]4N=CC(=C4N=C3)C5=CC=NC=C5",3.028,4,0,6]
["S7842","LY3009120","b9","L6200-29","in 2mM DMSO","Autophagy,Raf","MAPK","LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. LY03009120 induces autophagy. Phase 1.",424.51,"1454682-72-4",{"v":3,"d":"3.00"},7.07,"<1","N/A","http://selleckchem.com/products/ly3009120.html","C23H29FN6O","Free Base","DP-4978","CNC1=NC=C2C=C(C(=NC2=N1)C)C3=CC(=C(F)C=C3C)NC(=O)NCCC(C)(C)C",4.158,4,3,6]
["S8113","BI-9564","c9","L6200-29","in 2mM DMSO","Epigenetic Reader Domain","Epigenetics","BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains with the IC50 of 75 nM and 3.4 µM, respectively.",353.41,"1883429-22-8",{"v":3,"d":"3.00"},8.49,"<1","N/A","http://selleckchem.com/products/bi-9564.html","C20H23N3O3","Free Base","N/A","COC1=C(CN(C)C)C=C(OC)C(=C1)C2=CN(C)C(=O)C3=C2C=CN=C3",1.301,4,0,5]
["S8138","Molidustat (BAY 85-3934)","d9","L6200-29","in 2mM DMSO","HIF","Angiogenesis","Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2.",{"v":314.3,"d":"314.30"},"1154028-82-6",{"v":3,"d":"3.00"},9.55,"<1","N/A","http://selleckchem.com/products/molidustat-(bay85-3934).html","C13H14N8O2","free base","N/A","O=C1N(NC=C1[N]2C=CN=N2)C3=NC=NC(=C3)N4CCOCC4",{"v":0,"d":"0.000"},0,0,0]
["S8229","Brigatinib (AP26113)","e9","L6200-29","in 2mM DMSO","ALK,EGFR,FLT3,IGF-1R,ROS1","Angiogenesis","Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.",584.09,"1197953-54-0",{"v":3,"d":"3.00"},5.14,"<1","N/A","http://www.selleck.cn/products/brigatinib-ap26113.html","C29H39ClN7O2P","Free Base","N/A","COC1=C(NC2=NC(=C(Cl)C=N2)NC3=CC=CC=C3[P](C)(C)=O)C=CC(=C1)N4CCC(CC4)N5CCN(C)CC5",5.084,6,2,8]
["S8527","ROC-325","f9","L6200-29","in 2mM DMSO","Autophagy","Autophagy","ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.",503.06,"1859141-26-6",{"v":4,"d":"4.00"},7.95,"<1","N/A","http://selleckchem.com/products/roc-325.html","C28H27ClN4OS","free base","N/A","CN(CCNC1=CC=NC2=C1C=CC(=C2)Cl)CCNC3=CC=C(C)C4=C3C(=O)C5=CC=CC=C5S4",6.264,2,2,8]
["S9246","Tiliroside","g9","L6200-29","in 2mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.",594.52,"20316-62-5",{"v":3,"d":"3.00"},5.05,"N/A","N/A","https://www.selleckchem.com/products/tiliroside.html","C30H26O13","free base","N/A","OC1C(O)C(COC(=O)\\C=C\\C2=CC=C(O)C=C2)OC(OC3=C(OC4=C(C(=CC(=C4)O)O)C3=O)C5=CC=C(O)C=C5)C1O",2.212,6,7,8]
["S8875","MKC8866","h9","L6200-29","in 2mM DMSO","IRE1","ER stress & UPR","MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29 μM for human IRE1α in vitro.",361.35,"1338934-59-0",{"v":3,"d":"3.00"},{"v":8.3,"d":"8.30"},"˂1","N/A","http://www.selleckchem.com/products/mkc8866.html","C18H19NO7","Free Base","IRE1-IN-8866","COC1=C(O)C(=C2OC(=O)C(=C(C)C2=C1)CC(=O)N3CCOCC3)C=O",0.943,6,1,4]
["S0399","SJB2-043","a10","L6200-29","in 2mM DMSO","DUB","Ubiquitin","SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.",275.26,"63388-44-3",{"v":1.5,"d":"1.50"},5.45,"<1","N/A","http://www.selleckchem.com/products/sjb2-043.html","C17H9NO3","free base","N/A","O=C1C2=C(N=C(O2)C3=CC=CC=C3)C(=O)C4=C1C=CC=C4",{"v":3.35,"d":"3.350"},4,0,1]
["S3299","Demethyleneberberine","b10","L6200-29","in 2mM DMSO","AMPK,Interleukins,NF-κB,Peroxidases,TNF-alpha","Immunology & Inflammation","Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.",324.35,"25459-91-0",{"v":3,"d":"3.00"},9.25,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/demethyleneberberine.html","C19H18NO4","free base","DMB","COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(O)C=C4CC3)O",{"v":3.71,"d":"3.710"},2,2,2]
["S3304","Stylopine","c10","L6200-29","in 2mM DMSO","COX,Interleukins,NOS,PGES,TNF-alpha","Immunology & Inflammation","Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.",323.34,"4312-32-7",{"v":2.5,"d":"2.50"},7.73,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/stylopine-trahydocoptisine-.html","C19H17NO4","free base","(R,S)-Stylopine, Tetrahydrocoptisine","C1OC2=CC3=C(C=C2O1)C4CC5=CC=C6OCOC6=C5CN4CC3",3.201,4,0,0]
["S8274","STO-609","d10","L6200-29","in 2mM DMSO","AMPK,Autophagy,CaMK","Neuronal Signaling","STO-609 is a specific inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase(CaM-KK) that inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/ml, respectively, and also inhibits their autophosphorylation activities. STO-609 inhibits AMPKK activity and inhibits autophagy.",314.29,"52029-86-4","N/A",{"v":2,"d":"2.00"},"N/A","N/A","http://selleckchem.com/products/sto-609.html","C19H10N2O3","free base","N/A","OC(=O)C1=CC=C2C3=NC4=C(C=CC=C4)[N]3C(=O)C5=C2C1=CC=C5",3.633,3,0,1]
["S1911","Disodium Cromoglycate","a2","L6200-30","in 2mM Water","Calcium Channel","Transmembrane Transporters","Disodium Cromoglycate (Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium) is an antiallergic drug with IC50 of 39 μg/mL.",512.33,"15826-37-6","<1","N/A",{"v":2,"d":"2.00"},{"v":3.9,"d":"3.90"},"http://selleckchem.com/products/disodium-Cromoglycate.html","C23H14O11.2Na","Disodium Salt","Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium","[Na+].[Na+].OC(COC1=C2C(=O)C=C(OC2=CC=C1)C([O-])=O)COC3=CC=CC4=C3C(=O)C=C(O4)C([O-])=O",-1.178,6,1,8]
["S1982","Adenine sulfate","b2","L6200-30","in 2mM Water","DNA/RNA Synthesis","DNA Damage/DNA Repair","Adenine sulfate(Adenine hemisulfate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.",368.33,"321-30-2","<1","N/A",{"v":2,"d":"2.00"},5.43,"http://selleckchem.com/products/adenine-sulfate.html","2(C5H5N5).H2SO4","Sulfate","Adenine hemisulfate","NC1=NC=NC2=C1[NH]C=N2.NC3=NC=NC4=C3[NH]C=N4.O[S](O)(=O)=O",-1.498,6,4,0]
["S8030","Plerixafor (AMD3100)","c2","L6200-30","in 2mM Water","CXCR,HIV","GPCR & G Protein","Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication.",502.78,"110078-46-1","<1","N/A",{"v":3,"d":"3.00"},5.97,"http://selleckchem.com/products/plerixafor.html","C28H54N8","Free Base","JM 3100, SID791","C1CNCCNCCCN(CCNC1)CC2=CC=C(CN3CCCNCCNCCCNCC3)C=C2",{"v":-0.52,"d":"-0.520"},0,6,4]