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{"sheet":"General Information","index":0,"n_rows":94,"n_cols":14,"rows_kept":94,"merged":[[0,3,0,13],[1,1,1,13],[2,0,2,13],[3,1,3,13],[4,1,4,2],[4,3,4,13],[5,1,5,2],[5,3,5,13],[6,1,7,2],[6,3,6,13],[7,3,7,13],[8,1,8,2],[8,3,8,13],[9,1,10,2],[9,3,9,13],[10,3,10,13],[11,3,11,13],[14,1,14,13],[16,1,17,1],[16,2,17,2],[16,9,17,9],[16,10,17,10],[16,11,17,11],[16,12,17,12],[16,13,17,13],[18,1,19,1],[18,2,19,2],[18,9,19,9],[18,10,19,10],[18,11,19,11],[18,12,19,12],[18,13,19,13],[20,1,21,1],[20,2,21,2],[20,9,21,9],[20,10,21,10],[20,11,21,11],[20,12,21,12],[20,13,21,13],[22,1,23,1],[22,2,23,2],[22,9,23,9],[22,10,23,10],[22,11,23,11],[22,12,23,12],[22,13,23,13],[24,1,25,1],[24,2,25,2],[24,8,25,8],[24,9,25,9],[24,10,25,10],[24,11,25,11],[24,12,25,12],[24,13,25,13],[26,1,27,1],[26,2,27,2],[26,8,27,8],[26,9,27,9],[26,10,27,10],[26,11,27,11],[26,12,27,12],[26,13,27,13],[28,1,29,1],[28,2,29,2],[28,8,29,8],[28,9,29,9],[28,10,29,10],[28,11,29,11],[28,12,29,12],[28,13,29,13],[30,1,31,1],[30,2,31,2],[30,8,31,8],[30,9,31,9],[30,10,31,10],[30,11,31,11],[30,12,31,12],[30,13,31,13],[35,1,35,13],[37,1,38,1],[37,2,38,2],[37,4,38,4],[37,5,38,5],[37,6,38,6],[37,7,38,7],[37,8,38,8],[37,9,38,9],[37,10,38,10],[37,11,38,11],[37,12,38,12],[37,13,38,13],[39,1,40,1],[39,2,40,2],[39,4,40,4],[39,5,40,5],[39,6,40,6],[39,7,40,7],[39,8,40,8],[39,9,40,9],[39,10,40,10],[39,11,40,11],[39,12,40,12],[39,13,40,13],[41,1,42,1],[41,2,42,2],[41,3,42,3],[41,4,42,4],[41,5,42,5],[41,6,42,6],[41,7,42,7],[41,8,42,8],[41,9,42,9],[41,10,42,10],[41,11,42,11],[41,12,42,12],[41,13,42,13],[43,1,44,1],[43,2,44,2],[43,3,44,3],[43,4,44,4],[43,5,44,5],[43,6,44,6],[43,7,44,7],[43,8,44,8],[43,9,44,9],[43,10,44,10],[43,11,44,11],[43,12,44,12],[43,13,44,13],[45,1,46,1],[45,2,46,2],[45,3,46,3],[45,4,46,4],[45,5,46,5],[45,6,46,6],[45,7,46,7],[45,8,46,8],[45,9,46,9],[45,10,46,10],[45,11,46,11],[45,12,46,12],[45,13,46,13],[47,1,48,1],[47,2,48,2],[47,3,48,3],[47,4,48,4],[47,5,48,5],[47,6,48,6],[47,7,48,7],[47,8,48,8],[47,9,48,9],[47,10,48,10],[47,11,48,11],[47,12,48,12],[47,13,48,13],[49,1,50,1],[49,2,50,2],[49,3,50,3],[49,4,50,4],[49,5,50,5],[49,6,50,6],[49,7,50,7],[49,8,50,8],[49,9,50,9],[49,10,50,10],[49,11,50,11],[49,12,50,12],[49,13,50,13],[51,1,52,1],[51,2,52,2],[51,3,52,3],[51,4,52,4],[51,5,52,5],[51,6,52,6],[51,7,52,7],[51,8,52,8],[51,9,52,9],[51,10,52,10],[51,11,52,11],[51,12,52,12],[51,13,52,13],[56,1,56,13],[58,1,59,1],[58,2,59,2],[58,4,59,4],[58,5,59,5],[58,6,59,6],[58,7,59,7],[58,8,59,8],[58,9,59,9],[58,10,59,10],[58,11,59,11],[58,12,59,12],[58,13,59,13],[60,1,61,1],[60,2,61,2],[60,4,61,4],[60,5,61,5],[60,6,61,6],[60,7,61,7],[60,8,61,8],[60,9,61,9],[60,10,61,10],[60,11,61,11],[60,12,61,12],[60,13,61,13],[62,1,63,1],[62,2,63,2],[62,4,63,4],[62,5,63,5],[62,6,63,6],[62,7,63,7],[62,8,63,8],[62,9,63,9],[62,10,63,10],[62,11,63,11],[62,12,63,12],[62,13,63,13],[64,1,65,1],[64,2,65,2],[64,4,65,4],[64,5,65,5],[64,6,65,6],[64,7,65,7],[64,8,65,8],[64,9,65,9],[64,10,65,10],[64,11,65,11],[64,12,65,12],[64,13,65,13],[66,1,67,1],[66,2,67,2],[66,3,67,3],[66,4,67,4],[66,5,67,5],[66,6,67,6],[66,7,67,7],[66,8,67,8],[66,9,67,9],[66,10,67,10],[66,11,67,11],[66,12,67,12],[66,13,67,13],[68,1,69,1],[68,2,69,2],[68,3,69,3],[68,4,69,4],[68,5,69,5],[68,6,69,6],[68,7,69,7],[68,8,69,8],[68,9,69,9],[68,10,69,10],[68,11,69,11],[68,12,69,12],[68,13,69,13],[70,1,71,1],[70,2,71,2],[70,3,71,3],[70,4,71,4],[70,5,71,5],[70,6,71,6],[70,7,71,7],[70,8,71,8],[70,9,71,9],[70,10,71,10],[70,11,71,11],[70,12,71,12],[70,13,71,13],[72,1,73,1],[72,2,73,2],[72,3,73,3],[72,4,73,4],[72,5,73,5],[72,6,73,6],[72,7,73,7],[72,8,73,8],[72,9,73,9],[72,10,73,10],[72,11,73,11],[72,12,73,12],[72,13,73,13],[77,1,77,13],[79,1,80,1],[79,2,80,2],[79,4,80,4],[79,5,80,5],[79,6,80,6],[79,7,80,7],[79,8,80,8],[79,9,80,9],[79,10,80,10],[79,11,80,11],[79,12,80,12],[79,13,80,13],[81,1,82,1],[81,2,82,2],[81,3,82,3],[81,4,82,4],[81,5,82,5],[81,6,82,6],[81,7,82,7],[81,8,82,8],[81,9,82,9],[81,10,82,10],[81,11,82,11],[81,12,82,12],[81,13,82,13],[83,1,84,1],[83,2,84,2],[83,3,84,3],[83,4,84,4],[83,5,84,5],[83,6,84,6],[83,7,84,7],[83,8,84,8],[83,9,84,9],[83,10,84,10],[83,11,84,11],[83,12,84,12],[83,13,84,13],[85,1,86,1],[85,2,86,2],[85,3,86,3],[85,4,86,4],[85,5,86,5],[85,6,86,6],[85,7,86,7],[85,8,86,8],[85,9,86,9],[85,10,86,10],[85,11,86,11],[85,12,86,12],[85,13,86,13],[87,1,88,1],[87,2,88,2],[87,3,88,3],[87,4,88,4],[87,5,88,5],[87,6,88,6],[87,7,88,7],[87,8,88,8],[87,9,88,9],[87,10,88,10],[87,11,88,11],[87,12,88,12],[87,13,88,13],[89,1,90,1],[89,2,90,2],[89,3,90,3],[89,4,90,4],[89,5,90,5],[89,6,90,6],[89,7,90,7],[89,8,90,8],[89,9,90,9],[89,10,90,10],[89,11,90,11],[89,12,90,12],[89,13,90,13],[91,1,92,1],[91,2,92,2],[91,3,92,3],[91,4,92,4],[91,5,92,5],[91,6,92,6],[91,7,92,7],[91,8,92,8],[91,9,92,9],[91,10,92,10],[91,11,92,11],[91,12,92,12],[91,13,92,13],[93,1,94,1],[93,2,94,2],[93,3,94,3],[93,4,94,4],[93,5,94,5],[93,6,94,6],[93,7,94,7],[93,8,94,8],[93,9,94,9],[93,10,94,10],[93,11,94,11],[93,12,94,12],[93,13,94,13]]}
[{"$nulls":3},"Exosome Secretion Related Compound Library  (96-well)-L8800"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 51 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L8800-01;     In 2 mM DMSO : Plate layout L8800-03"]
[{"$nulls":3},"In 10 mM Water: Plate layout L8800-02;      In 2 mM Water  : Plate layout L8800-04"]
[]
[]
[null,"Plate layout: L8800-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1049","S1645","S2449","S5032","S6454","S8279","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Y-27632 2HCl","Ketoprofen","Colforsin","Mephenesin","Docosahexaenoic Acid","(±)-Shikonin"]
[null,"b","Empty","S1208","S1732","S2456","S5658","S7199","S9507","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Doxorubicin (Adriamycin) HCl","Mitotane","Chlorpromazine HCl","Omeprazole Sodium","DBeQ","(−)-Norepinephrine"]
[null,"c","Empty","S1209","S1743","S2866","S5683","S7396","S7321","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Fluorouracil (5-Fluorouracil, 5-FU)","Esomeprazole magnesium","U-104","Isoproterenol sulfate dihydrate","Calpeptin","FIPI"]
[null,"d","Empty","S1322","S1811","S4099","S5749","S7483","S5608","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Dexamethasone (MK-125)","Amiloride (MK-870) HCl","Dexlansoprazole","Chlorpromazine","DMOG","Pantoprazole sodium hydrate"]
[null,"e","Empty","S1342","S1916","S4178","S5750","S7685","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Genistein (NPI 031L)","Sulfisoxazole","Climbazole","DL-Norepinephrine hydrochloride","SecinH3"]
[null,"f","Empty","S1354","S2024","S4377","S5768","S7958","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Lansoprazole","Ketotifen Fumarate","Imipramine HCl","Fenoterol hydrobromide","Lificiguat (YC-1)"]
[null,"g","Empty","S1389","S2105","S4538","S5769","S8047","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Omeprazole","Pantoprazole","Pantoprazole sodium","Fenoterol","Dynasore"]
[null,"h","Empty","S1453","S2233","S4878","S5913","S8057","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Tipifarnib (R115777)","Esomeprazole sodium","Neticonazole Hydrochloride","Cambinol","Pacritinib (SB1518)"]
[]
[]
[]
[null,"Plate layout: L8800-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2560","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Amiloride HCl dihydrate"]
[null,"b","Empty","S5220","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"D-Pantethine"]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[]
[]
[]
[null,"Plate layout: L8800-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1019","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Canertinib (CI-1033)"]
[null,"b","Empty","S1046","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Vandetanib (ZD6474)"]
[null,"c","Empty","S1353","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ketoconazole (R 41400)"]
[null,"d","Empty","S2152","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Sitafloxacin Hydrate"]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[]
[]
[]
[null,"Plate layout: L8800-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1346","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Heparin sodium"]
[null,"b","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L8800-Exosome-Secretion-51 cpds","index":1,"n_rows":52,"n_cols":23,"rows_kept":52}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1049","Y-27632 2HCl","a2","L8800-01","in 10mM DMSO","Autophagy,ROCK","Cell Cycle","Y-27632 2HCl is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.",320.26,"129830-38-2",{"v":64,"d":"64.00"},199.84,{"v":14,"d":"14.00"},43.71,"http://selleckchem.com/products/Y-27632.html","C14H21N3O.2HCl","Dihydrochloride","N/A","Cl.Cl.CC(N)C1CCC(CC1)C(=O)NC2=CC=NC=C2",1.871,2,2,3]
["S1208","Doxorubicin (Adriamycin) HCl","b2","L8800-01","in 10mM DMSO","ADC Cytotoxin,AMPK,Antibiotics,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,HIV,Mitophagy,Topoisomerase","DNA Damage/DNA Repair","Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.",579.98,"25316-40-9",{"v":100,"d":"100.00"},172.42,{"v":20,"d":"20.00"},34.48,"http://selleckchem.com/products/Adriamycin.html","C27H29NO11.HCl","Hydrochloride","NSC 123127, DOX, Doxorubicin hydrochloride, Hydroxydaunorubicin HCl,Adriamycin HCl","Cl.COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1",0.338,6,5,5]
["S1209","Fluorouracil (5-Fluorouracil, 5-FU)","c2","L8800-01","in 10mM DMSO","Apoptosis related,DNA/RNA Synthesis,HIV,Nucleoside Analog/Antimetabolite,Thymidylate Synthase","DNA Damage/DNA Repair","Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.",130.08,"51-21-8",{"v":26,"d":"26.00"},199.88,"<1","N/A","http://selleckchem.com/products/Adrucil(Fluorouracil).html","C4H3FN2O2","free base","NSC 19893,5-Fluorouracil, 5-FU","FC1=CNC(=O)NC1=O",-1.102,2,2,0]
["S1322","Dexamethasone (MK-125)","d2","L8800-01","in 10mM DMSO","Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy","Immunology & Inflammation","Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.",392.46,"50-02-2",{"v":79,"d":"79.00"},201.29,"<1","N/A","http://selleckchem.com/products/Dexamethasone.html","C22H29FO5","free base","NSC 34521, Hexadecadrol, Prednisolone F,MK-125","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO",1.708,2,2,2]
["S1342","Genistein (NPI 031L)","e2","L8800-01","in 10mM DMSO","EGFR,Topoisomerase","Protein Tyrosine Kinase","Genistein (NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK)  which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.",270.24,"446-72-0",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/Genistein.html","C15H10O5","free base","NPI 031L","OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O",{"v":2.14,"d":"2.140"},2,3,1]
["S1354","Lansoprazole","f2","L8800-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. Lansoprazole prevents the stomach from producing gastric acid.",369.36,"103577-45-3",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/Lansoprazole.html","C16H14F3N3O2S","free base","A-65006, AG-1749","CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2",3.442,4,1,6]
["S1389","Omeprazole","g2","L8800-01","in 10mM DMSO","ATPase,Autophagy,Proton Pump","Transmembrane Transporters","Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.",345.42,"73590-58-6",{"v":69,"d":"69.00"},199.76,"<1","N/A","http://selleckchem.com/products/Omeprazole.html","C17H19N3O3S","free base","N/A","COC1=CC=C2[NH]C(=NC2=C1)[S](=O)CC3=C(C)C(=C(C)C=N3)OC",2.904,5,1,5]
["S1453","Tipifarnib (R115777)","h2","L8800-01","in 10mM DMSO","FTase,Transferase","Metabolism","Tipifarnib (R115777, IND 58359) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.",{"v":489.4,"d":"489.40"},"192185-72-1",{"v":14,"d":"14.00"},28.61,"<1","N/A","http://selleckchem.com/products/Tipifarnib(R115777).html","C27H22Cl2N4O","free base","IND 58359","C[N]1C=NC=C1C(N)(C2=CC=C(Cl)C=C2)C3=CC4=C(C=C3)N(C)C(=O)C=C4C5=CC(=CC=C5)Cl",4.808,2,1,4]
["S1645","Ketoprofen","a3","L8800-01","in 10mM DMSO","COX","Neuronal Signaling","Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.",254.28,"22071-15-4",{"v":51,"d":"51.00"},200.57,"<1","N/A","http://selleckchem.com/products/Ketoprofen(Actron).html","C16H14O3","free base","RP-19583","CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2",3.361,2,0,4]
["S1732","Mitotane","b3","L8800-01","in 10mM DMSO","Others","Others","Mitotane (NCI-C04933), is an antineoplastic medication used in the treatment of adrenocortical carcinoma.",320.04,"53-19-0",{"v":64,"d":"64.00"},199.98,"<1","N/A","http://selleckchem.com/products/Mitotane(Lysodren).html","C14H10Cl4","free base","NCI-C04933","ClC(Cl)C(C1=CC=C(Cl)C=C1)C2=C(Cl)C=CC=C2",5.745,0,0,3]
["S1743","Esomeprazole magnesium","c3","L8800-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Esomeprazole Magnesium(NEXIUM) is a proton pump inhibitor to reduce gastric acid secretion through inhibition of H(+)/K(+)-ATPase in gastric parietal cells.",713.12,"161973-10-0",{"v":143,"d":"143.00"},200.53,"<1","N/A","http://selleckchem.com/products/nexium-esomeprazole-magnesium.html","C34H36MgN6O6S2","Magnesium salt","NEXIUM","[Mg++].COC1=CC2=C([N-]C(=N2)[S](=O)CC3=C(C)C(=C(C)C=N3)OC)C=C1.COC4=CC5=C([N-]C(=N5)[S](=O)CC6=NC=C(C)C(=C6C)OC)C=C4",{"v":6.1,"d":"6.100"},10,0,10]
["S1811","Amiloride (MK-870) HCl","d3","L8800-01","in 10mM DMSO","Calcium Channel,Serine Protease,Sodium Channel","Transmembrane Transporters","Amiloride (MK-870 HCl) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).",266.09,"2016-88-8",{"v":53,"d":"53.00"},199.18,{"v":6,"d":"6.00"},22.55,"http://selleckchem.com/products/Amiloride-hydrochloride(Midamor).html","C6H8ClN7O.HCl","Hydrochloride","MK-870 HCl","Cl.NC(=N)NC(=O)C1=NC(=C(N)N=C1N)Cl",-0.366,3,4,2]
["S1916","Sulfisoxazole","e3","L8800-01","in 10mM DMSO","Bacterial","Microbiology","Sulfisoxazole (NU-445) is a sulfonamide antibacterial with an oxazole substituent.",{"v":267.3,"d":"267.30"},"127-69-5",{"v":53,"d":"53.00"},198.28,"<1","N/A","http://selleckchem.com/products/Sulfisoxazole.html","C11H13N3O3S","free base","NU-445","CC1=NOC(=C1C)N[S](=O)(=O)C2=CC=C(N)C=C2",0.918,4,2,3]
["S2024","Ketotifen Fumarate","f3","L8800-01","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Ketotifen Fumarate(HC 20511 fumarate) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.",{"v":425.5,"d":"425.50"},"34580-14-8",{"v":8,"d":"8.00"},{"v":18.8,"d":"18.80"},"<1","N/A","http://selleckchem.com/products/ketotifen-fumarate-zaditor.html","C19H19NOS.C4H4O4","Fumarate","HC 20511 fumarate","CN1CCC(CC1)=C2C3=C(CC(=O)C4=C2C=CS4)C=CC=C3.OC(=O)\\C=C\\C(O)=O",0.772,3,0,2]
["S2105","Pantoprazole","g3","L8800-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",383.37,"102625-70-7",{"v":76,"d":"76.00"},198.24,"<1","N/A","http://selleckchem.com/products/pantoprazole-protonix.html","C16H15F2N3O4S","free base","SKFSKF96022, BY-1023","COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=CC=C(OC(F)F)C=C3[NH]2",2.737,6,1,7]
["S2233","Esomeprazole sodium","h3","L8800-01","in 10mM DMSO","ATPase","Transmembrane Transporters","Esomeprazole Sodium((S)-Omeprazole sodium, (-)-Omeprazole sodium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.",{"v":367.4,"d":"367.40"},"161796-78-7",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://selleckchem.com/products/esomeprazole-sodium.html","C17H18N3O3S.Na","Sodium salt","(S)-Omeprazole sodium, (-)-Omeprazole sodium","COC1=CC=C2[N]([Na])C(=NC2=C1)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S2449","Colforsin","a4","L8800-01","in 10mM DMSO","Autophagy,cAMP,FXR","GPCR & G Protein","Colforsin (Forskolin, HL 362, Coleonol) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.",{"v":410.5,"d":"410.50"},"66575-29-9",{"v":82,"d":"82.00"},199.76,"<1","N/A","http://selleckchem.com/products/forskolin.html","C22H34O7","free base","Forskolin, HL 362, Coleonol","CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C3(O)C(=O)CC(C)(OC13C)C=C",0.837,4,2,3]
["S2456","Chlorpromazine HCl","b4","L8800-01","in 10mM DMSO","Dopamine Receptor,Potassium Channel","Neuronal Signaling","Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.",355.33,"69-09-0",{"v":71,"d":"71.00"},199.81,{"v":71,"d":"71.00"},199.81,"http://selleckchem.com/products/Chlorpromazine-hydrochloride(Sonazine).html","C17H19ClN2S.HCl","Hydrochloride","Sonazine","Cl.CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",5.121,0,0,4]
["S2866","U-104","c4","L8800-01","in 10mM DMSO","Carbonic Anhydrase","Metabolism","U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.",309.32,"178606-66-1",{"v":62,"d":"62.00"},200.44,"<1","N/A","http://selleckchem.com/products/u-104.html","C13H12FN3O3S","free base","MST-104, NSC 213841, SLC-0111, WBI-5111","N[S](=O)(=O)C1=CC=C(NC(=O)NC2=CC=C(F)C=C2)C=C1",1.433,3,3,3]
["S4099","Dexlansoprazole","d4","L8800-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Dexlansoprazole (T 168390, TAK 390,(R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase proton pump in the gastric parietal cell.",369.36,"138530-94-6",{"v":74,"d":"74.00"},200.35,"<1","N/A","http://selleckchem.com/products/dexlansoprazole.html","C16H14F3N3O2S","free base","T 168390, TAK 390,(R)-Lansoprazole","CC1=C(C[S](=O)C2=NC3=C([NH]2)C=CC=C3)N=CC=C1OCC(F)(F)F",3.442,4,1,6]
["S4178","Climbazole","e4","L8800-01","in 10mM DMSO","Fungal","Microbiology","Climbazole(BAY-e 6975) is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits.",292.76,"38083-17-9",{"v":59,"d":"59.00"},201.53,"<1","N/A","http://selleckchem.com/products/climbazole.html","C15H17ClN2O2","free base","BAY-e 6975","CC(C)(C)C(=O)C(OC1=CC=C(Cl)C=C1)[N]2C=CN=C2",3.766,3,0,5]
["S4377","Imipramine HCl","f4","L8800-01","in 10mM DMSO","5-HT Receptor,Serotonin Transporter","Neuronal Signaling","Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).",316.87,"113-52-0",{"v":63,"d":"63.00"},198.82,{"v":63,"d":"63.00"},198.82,"http://www.selleckchem.com/products/imipramine-hcl.html","C19H25ClN2","hydrochloride","Melipramine HCl,G 22355","Cl.CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2",4.769,0,0,4]
["S4538","Pantoprazole sodium","g4","L8800-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.",405.35,"138786-67-1",{"v":81,"d":"81.00"},199.83,{"v":81,"d":"81.00"},199.83,"http://selleckchem.com/products/pantoprazole-sodium.html","C16H14F2N3NaO4S","Free Base","SKF96022 sodium, BY-1023 sodium","[Na+].COC1=CC=NC(=C1OC)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F",2.883,6,0,7]
["S4878","Neticonazole Hydrochloride","h4","L8800-01","in 10mM DMSO","Fungal","Microbiology","Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.",{"v":338.9,"d":"338.90"},"130773-02-3",{"v":67,"d":"67.00"},{"v":197.7,"d":"197.70"},"N/A","N/A","http://selleckchem.com/products/neticonazole-hydrochloride.html","C17H22N2OS.HCl","hydrochloride","N/A","Cl.CCCCCOC1=CC=CC=C1C(=C\\SC)/[N]2C=CN=C2",3.838,2,0,8]
["S5032","Mephenesin","a5","L8800-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.",182.22,"59-47-2",{"v":36,"d":"36.00"},197.56,{"v":30,"d":"30.00"},164.64,"http://selleckchem.com/products/mephenesin.html","C10H14O3","free base","Decontractyl, Cresoxydiol, Memphenesin, Mephedan","CC1=C(OCC(O)CO)C=CC=C1",1.249,1,2,4]
["S5658","Omeprazole Sodium","b5","L8800-01","in 10mM DMSO","P450 (e.g. CYP17),Proton Pump","Transmembrane Transporters","Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.",{"v":367.4,"d":"367.40"},"95510-70-6",{"v":73,"d":"73.00"},198.69,{"v":73,"d":"73.00"},198.69,"http://www.selleckchem.com/products/omeprazole-sodium.html","C17H18N3NaO3S","Sodium Salt","N/A","COC1=CC2=C(C=C1)[N]([Na])C(=N2)[S](=O)CC3=NC=C(C)C(=C3C)OC",3.008,5,0,5]
["S5683","Isoproterenol sulfate dihydrate","c5","L8800-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.",556.62,"299-95-6",{"v":100,"d":"100.00"},179.66,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/isoproterenol-sulfate-dihydrate.html","C22H40N2O12S","dihydrate","N/A","O.O.CC(C)NCC(O)C1=CC=C(O)C(=C1)O.CC(C)NCC(O)C2=CC=C(O)C(=C2)O.O[S](O)(=O)=O",1.177,0,8,8]
["S5749","Chlorpromazine","d5","L8800-01","in 10mM DMSO","5-HT Receptor,Dopamine Receptor,Potassium Channel,Sodium Channel","Neuronal Signaling","Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.",318.86,"50-53-3",{"v":64,"d":"64.00"},200.72,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/chlorpromazine.html","C17H19ClN2S","Free Base","CPZ","CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2",4.739,0,0,4]
["S5750","DL-Norepinephrine hydrochloride","e5","L8800-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.",205.64,"55-27-6",{"v":41,"d":"41.00"},199.38,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/dl-norepinephrine-hydrochloride.html","C8H12ClNO3","hydrochloride","noradrenaline hydrochloride","Cl.NCC(O)C1=CC(=C(O)C=C1)O",0.323,0,4,2]
["S5768","Fenoterol hydrobromide","f5","L8800-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.",384.26,"1944-12-3",{"v":77,"d":"77.00"},200.39,{"v":11,"d":"11.00"},28.63,"http://www.selleckchem.com/products/fenoterol-hydrobromide.html","C17H22BrNO4","hydrobromide","Phenoterol hydrobromide","Br.CC(CC1=CC=C(O)C=C1)NCC(O)C2=CC(=CC(=C2)O)O",2.904,0,5,6]
["S5769","Fenoterol","g5","L8800-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity.",303.35,"13392-18-2",{"v":61,"d":"61.00"},201.09,"<1","N/A","http://www.selleckchem.com/products/fenoterol.html","C17H21NO4","Free Base","Phenoterol","CC(CC1=CC=C(O)C=C1)NCC(O)C2=CC(=CC(=C2)O)O",2.413,0,5,6]
["S5913","Cambinol","h5","L8800-01","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).",360.43,"14513-15-6",{"v":21,"d":"21.00"},58.26,"<1","N/A","http://www.selleckchem.com/products/cambinol.html","C21H16N2O2S","Free Base","N/A","OC1=C(CC2=C(NC(=S)NC2=O)C3=CC=CC=C3)C4=CC=CC=C4C=C1",4.431,1,3,3]
["S6454","Docosahexaenoic Acid","a6","L8800-01","in 10mM DMSO","Others","Others","Docosahexaenoic Acid (DHA, Cervonic acid, Doconexent) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults.",328.49,"6217-54-5",{"v":66,"d":"66.00"},200.92,{"v":8,"d":"8.00"},24.35,"http://www.selleck.cn/products/docosahexaenoic-acid.html","C22H32O2","Free Base","DHA, Cervonic acid, Doconexent","CC\\C=C/C/C=C\\C\\C=C/C/C=C\\C\\C=C/C/C=C\\CCC(O)=O",6.462,1,0,14]
["S7199","DBeQ","b6","L8800-01","in 10mM DMSO","p97","Ubiquitin","DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.",340.42,"177355-84-9",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://selleckchem.com/products/dbeq.html","C22H20N4","free base","JRF 12","C(NC1=NC2=CC=CC=C2C(=N1)NCC3=CC=CC=C3)C4=CC=CC=C4",5.232,2,2,6]
["S7396","Calpeptin","c6","L8800-01","in 10mM DMSO","Apoptosis related,Cysteine Protease","Proteases","Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.",362.46,"117591-20-5",{"v":72,"d":"72.00"},198.64,"<1","N/A","http://selleckchem.com/products/calpeptin.html","C20H30N2O4","free base","N/A","CCCCC(NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",{"v":3.8,"d":"3.800"},4,2,12]
["S7483","DMOG","d6","L8800-01","in 10mM DMSO","Autophagy,HIF,Hydroxylase","Metabolism","DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.",175.14,"89464-63-1",{"v":35,"d":"35.00"},199.84,{"v":35,"d":"35.00"},199.84,"http://selleckchem.com/products/dmog.html","C6H9NO5","free base","Dimethyloxalylglycine","COC(=O)CNC(=O)C(=O)OC",-0.918,5,1,5]
["S7685","SecinH3","e6","L8800-01","in 10mM DMSO","cytohesin","Apoptosis","SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.",{"v":460.5,"d":"460.50"},"853625-60-2",{"v":92,"d":"92.00"},199.78,"<1","N/A","http://selleckchem.com/products/secinh3.html","C24H20N4O4S","free base","N/A","COC1=N[N](C2=CC=C(NC(=O)CSC3=CC=CC=C3)C=C2)C(=N1)C4=CC=C5OCOC5=C4",4.748,6,1,7]
["S7958","Lificiguat (YC-1)","f6","L8800-01","in 10mM DMSO","Guanylate Cyclase,HIF","Angiogenesis","Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).",304.34,"170632-47-0",{"v":60,"d":"60.00"},197.15,"<1","N/A","http://selleckchem.com/products/lificiguat-yc-1.html","C19H16N2O2","free base","N/A","OCC1=CC=C(O1)C2=N[N](CC3=CC=CC=C3)C4=C2C=CC=C4",4.078,2,1,4]
["S8047","Dynasore","g6","L8800-01","in 10mM DMSO","Autophagy,Dynamin,HSV","Cytoskeletal Signaling","Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM in a cell-free assay, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase. Dynasore suppresses mTORC1 activity and induces autophagy. Dynasore inhibits the entry of several viruses, including herpes simplex virus (HSV).",322.31,"304448-55-3",{"v":64,"d":"64.00"},198.57,"<1","N/A","http://selleckchem.com/products/dynasore.html","C18H14N2O4","free base","N/A","OC1=C(O)C=C(C=C1)\\C=N\\NC(=O)C2=C(O)C=C3C=CC=CC3=C2",2.865,2,4,3]
["S8057","Pacritinib (SB1518)","h6","L8800-01","in 10mM DMSO","FLT3,JAK","JAK/STAT","Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3.",472.58,"937272-79-2",{"v":11,"d":"11.00"},23.28,"<1","N/A","http://selleckchem.com/products/pacritinib-sb1518.html","C28H32N4O3","free base","N/A","C1CCN(C1)CCOC2=CC=C3NC4=NC=CC(=N4)C5=CC(=CC=C5)COC\\C=C\\COCC2=C3",4.547,5,1,4]
["S8279","(±)-Shikonin","a7","L8800-01","in 10mM DMSO","Anti-infection,Chloride Channel,COVID-19,NF-κB,PKM,Proteasome,TNF-alpha","Metabolism","(±)-Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.",{"v":288.3,"d":"288.30"},"54952-43-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/shikonin.html","C16H16O5","free base","Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["S9507","(−)-Norepinephrine","b7","L8800-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.",169.18,"51-41-2",{"v":11,"d":"11.00"},65.02,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/norepinephrine.html","C8H11NO3","Free Base","Arterenol, Levarterenol, L-Noradrenaline","NCC(O)C1=CC(=C(O)C=C1)O",-0.059,0,4,2]
["S7321","FIPI","c7","L8800-01","in 10mM DMSO","Phospholipase (e.g. PLA)","Metabolism","FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.",421.47,"939055-18-2",{"v":45,"d":"45.00"},106.77,"<1","N/A","http://www.selleckchem.com/products/fipi.html","C23H24FN5O2","free base","5-Fluoro-2-indolyl deschlorohalopemide","FC1=CC2=C([NH]C(=C2)C(=O)NCCN3CCC(CC3)N4C(=O)NC5=C4C=CC=C5)C=C1",2.656,2,3,5]
["S5608","Pantoprazole sodium hydrate","d7","L8800-01","in 10mM DMSO","ATPase,Proton Pump","Transmembrane Transporters","Pantoprazole (BY10232, SKF96022) sodium hydrate (Protonix) is a potent inhibitor of H+/K(+)-ATPase with IC50 of 6.8 μM.",864.75,"164579-32-2",{"v":100,"d":"100.00"},115.64,{"v":17,"d":"17.00"},19.66,"http://www.selleckchem.com/products/pantoprazole-sodium-hydrate.html","C32H34F4N6Na2O11S2","Sodium hydrate","Protonix, BY1023 sodium hydrate, SKF96022 sodium hydrate","O.O.O.[Na+].[Na+].COC1=C(OC)C(=NC=C1)C[S](=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F.COC4=C(OC)C(=NC=C4)C[S](=O)C5=NC6=C([N-]5)C=CC(=C6)OC(F)F",5.145,12,0,14]
["S2560","Amiloride HCl dihydrate","a2","L8800-02","in 10mM Water","Sodium Channel","Transmembrane Transporters","Amiloride HCl dihydrate(MK-870 hydrochloride dihydrate) is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.",302.12,"17440-83-4",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":17,"d":"17.00"},56.27,"http://selleckchem.com/products/amilorida.html","C6H8ClN7O.HCl.2H2O","hydrochloride & dihydrate","MK-870 hydrochloride dihydrate","O.O.Cl.NC(=N)NC(=O)C1=NC(=C(N)N=C1N)Cl",{"v":-0.78,"d":"-0.780"},3,4,2]
["S5220","D-Pantethine","b2","L8800-02","in 10mM Water","Vitamin","Metabolism","Pantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin) is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine and used as a dietary supplement for lowering blood cholesterol and triglycerides.",554.72,"16816-67-4","<1","N/A",{"v":100,"d":"100.00"},180.27,"http://selleckchem.com/products/d-pantethine.html","C22H42N4O8S2","free base","Bis-pantethine, Pantetina, Pantomin, Pantosin","CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO",-1.938,4,8,19]
["S1019","Canertinib (CI-1033)","a2","L8800-03","in 2mM DMSO","EGFR,HER2","Protein Tyrosine Kinase","Canertinib (CI-1033, PD183805) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.",485.94,"267243-28-7",{"v":2,"d":"2.00"},4.12,"<1","N/A","http://selleckchem.com/products/CI-1033(Canertinib).html","C24H25ClFN5O3","Free Base","PD183805","FC1=C(Cl)C=C(NC2=NC=NC3=CC(=C(NC(=O)C=C)C=C23)OCCCN4CCOCC4)C=C1",4.037,5,2,9]
["S1046","Vandetanib (ZD6474)","b2","L8800-03","in 2mM DMSO","Apoptosis related,Autophagy,EGFR,ROS,VEGFR","Protein Tyrosine Kinase","Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).",475.35,"443913-73-3",{"v":4,"d":"4.00"},8.41,"<1","N/A","http://selleckchem.com/products/Vandetanib.html","C22H24BrFN4O2","free base","ZD6474","COC1=CC2=C(C=C1OCC3CCN(C)CC3)N=CN=C2NC4=C(F)C=C(Br)C=C4",5.087,4,1,6]
["S1353","Ketoconazole (R 41400)","c2","L8800-03","in 2mM DMSO","Androgen Receptor,Fungal,P450 (e.g. CYP17)","Metabolism","Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.",531.43,"65277-42-1",{"v":5,"d":"5.00"},9.41,"<1","N/A","http://selleckchem.com/products/Ketoconazole.html","C26H28Cl2N4O4","free base","R 41400","CC(=O)N1CCN(CC1)C2=CC=C(OCC3COC(C[N]4C=CN=C4)(O3)C5=CC=C(Cl)C=C5Cl)C=C2",{"v":3.61,"d":"3.610"},5,0,7]
["S2152","Sitafloxacin Hydrate","d2","L8800-03","in 2mM DMSO","Antibiotics","Microbiology","Sitafloxacin Hydrate (DU-6859a) is a new-generation, broad-spectrum oral fluoroquinolone antibiotic.",436.84,"163253-35-8",{"v":4,"d":"4.00"},9.16,"<1","N/A","http://selleckchem.com/products/Sitafloxacin(DU-6859A).html","C19H18ClF2N3O3.3/2H2O","1.5 hydrate","DU-6859a","O.O.O.NC1CN(CC12CC2)C3=C(Cl)C4=C(C=C3F)C(=O)C(=CN4C5CC5F)C(O)=O.NC6CN(CC67CC7)C8=C(Cl)C9=C(C=C8F)C(=O)C(=CN9C%10CC%10F)C(O)=O",0.344,2,1,3]
["S1346","Heparin sodium","a2","L8800-04","in 2mM Water","Autophagy,Factor Xa,Thrombin","Proteases","Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins. Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin prevents the induction of autophagy.","6000-20000","9041-08-1","<1","N/A",{"v":100,"d":"100.00"},{"v":8,"d":"8.00"},"http://selleckchem.com/products/Heparin-sodium.html","(C12H16NS2Na3)20","Sodium salt","N/A","CCC1CC(N[R])C(OC1CO[S]([O-])(=O)=O)OC2C(O)C(O)C(OC3C(CO[R])OC(OC4C(O)C(O[S]([O-])(=O)=O)C(OC5C(O)C(N[S]([O-])(=O)=O)C(C)OC5CO[S]([O-])(=O)=O)OC4C([O-])=O)C(N[S]([O-])(=O)=O)C3[S]([O-])(=O)=O)OC2C([O-])=O",-22.565,13,7,27]