PI3K Ras MAPK Akt Vps34 mTOR Bcl-2/Bcl-xL AMPK IKKβ p53 HIFs mTORC1 Autophagy Atg13 Atg13 UVRAG Beclin-1 Vps15 Atg9 Atg9 Atg18 Atg5 Atg3 Atg4 Atg5 Atg7 LC3 LC3 LC3 LC3 Atg5 Atg5 Atg5 Atg6 Atg10 Atg12 Atg12 Atg16 Atg16 Atg16 Atg16 Atg12 Atg12 Atg5 Atg12 Atg12 Atg1 Atg17 Atg13 LKB1 Sestrins RAGs TSC 1/2 Rheb ULK1 Complex PTEN Ca 2+ CaM kinase III FOXOs Energy Depletion Stress Hypoxia Ammonia Limitation for Insulin,Growth Factors, or Hormones Autophagosome 4 Retrieval 3 Vesicle Elongation 5 Docking and Fusion 6 Vesicle Breakdownand Degradation 2 Isolation Membrane 2 Vesicle Nucleation PI3K Complex III 3 4 Active 1 Regulation of Induction Glucagon E1 E2 E2 Gly P1 Lysosome Autolysosome Cathepsins P P P P P P p53 ActivatorsAPR-246CBL0137p53 InhibitorsPifithrin-αPifithrin-μ Pan-PI3K Inhibitors3-MethyladenineLY294002DactolisibWortmanninSelective PI3K InhibitorsAlpelisib (PI3Kα)TGX-221 (p110β)AS-252424 (PI3Kγ)Idelalisib (p110δ) Pan-Akt InhibitorsMK-2206IpatasertibCapivasertibAkt ActivatorSC79Selective Akt InhibitorsA-674563 (AKT1)CCT128930 (AKT2) Autophagy InhibitorsHydroxychloroquineMRT68921SBI-0206965DC661PFK15Autophagy ActivatorsRapamycinMetformin mTOR InhibitorsRapamycinEverolimusAZD8055Torin 1SapanisertibmTOR Agonist3BDO P Energy Depletion Stress Hypoxia Depletion of Amino Acids Ammonia Glucagon Limitation for Insulin Growth Factors,or Hormones 2 Isolation Membrane 2 Vesicle Nucleation PI3K Complex III 3 4 1 Regulation of Induction Active Autophagosome 5 Docking and Fusion Cathepsins Lysosome 6 Vesicle Breakdown and Degradation Autolysosome 4 Retrieval 3 Vesicle Elongation E2 E2 E1 P1 Gly {{ board.text }} Ca2+ {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable