PI3K
Ras
MAPK
Akt
Vps34
mTOR
Bcl-2/Bcl-xL
AMPK
IKKβ
p53
HIFs
mTORC1
Autophagy
Atg13
Atg13
UVRAG
Beclin-1
Vps15
Atg9
Atg9
Atg18
Atg5
Atg3
Atg4
Atg5
Atg7
LC3
LC3
LC3
LC3
Atg5
Atg5
Atg5
Atg6
Atg10
Atg12
Atg12
Atg16
Atg16
Atg16
Atg16
Atg12
Atg12
Atg5
Atg12
Atg12
Atg1
Atg17
Atg13
LKB1
Sestrins
RAGs
TSC 1/2
Rheb
ULK1 Complex
PTEN
Ca
2+
CaM kinase III
FOXOs
Energy Depletion
Stress
Hypoxia
Ammonia
Limitation for Insulin,Growth Factors, or Hormones
Autophagosome
4 Retrieval
3 Vesicle Elongation
5 Docking and Fusion
6 Vesicle Breakdownand Degradation
2 Isolation Membrane
2 Vesicle Nucleation
PI3K Complex III
3
4
Active
1 Regulation of Induction
Glucagon
E1
E2
E2
Gly
P1
Lysosome
Autolysosome
Cathepsins
P
P
P
P
P
P
p53 ActivatorsAPR-246CBL0137p53 InhibitorsPifithrin-αPifithrin-μ
Pan-PI3K Inhibitors3-MethyladenineLY294002DactolisibWortmanninSelective PI3K InhibitorsAlpelisib (PI3Kα)TGX-221 (p110β)AS-252424 (PI3Kγ)Idelalisib (p110δ)
Pan-Akt InhibitorsMK-2206IpatasertibCapivasertibAkt ActivatorSC79Selective Akt InhibitorsA-674563 (AKT1)CCT128930 (AKT2)
Autophagy InhibitorsHydroxychloroquineMRT68921SBI-0206965DC661PFK15Autophagy ActivatorsRapamycinMetformin
mTOR InhibitorsRapamycinEverolimusAZD8055Torin 1SapanisertibmTOR Agonist3BDO
P
Energy Depletion
Stress
Hypoxia
Depletion
of Amino Acids
Ammonia
Glucagon
Limitation for Insulin
Growth Factors,or Hormones
2 Isolation Membrane
2 Vesicle Nucleation
PI3K Complex III
3
4
1 Regulation of Induction
Active
Autophagosome
5 Docking and Fusion
Cathepsins
Lysosome
6 Vesicle Breakdown
and Degradation
Autolysosome
4 Retrieval
3 Vesicle Elongation
E2
E2
E1
P1
Gly
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Ca2+
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Notes:
1:Clickable
2:Unclickable