P Notes: 1:Clickable 2:Unclickable cAMPPathway AxonalGrowth MKK4/7 REDD1 Cell Stress,Cytokines MicrogliaActivation GeneticMutations Environmental Toxins,Neurotoxins LRRK2 MutationPINK1Mutation AggregationLewy Bodies Proteosomal Degradation Post-Synaptic Signaling Blocked Neurodegeneration CellSurvival ROS Dopamine DopamineMetabolism Parkin PINK1 DJ-1 AKAP9 PP2A Caln Caln IP 3 R GeneExpression Cell Survival CaMKK CaMK4 Calm PP2B/CalnA1 CK1 PKG cGMP GTP NO Pi PPtase1 sGC bNOS bNOS DARPP32 Thr34 DARPP32 DARPP32 Thr72 β,γ β,γ i S AC ATP α-synucleinMisfolding α-synuclein Normal State TyrosineHydroxylase DopaDecarboxylase Dopamine Dopamine Dopamine PCP,Ketamine Glycine Glutamate D-Serine Par-4 Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Tyrosine L-DOPA Parkinson’s Disease State ATF1 CREM CREB CBP AMPAR, NMDAR AMPAR, NMDAR Apoptosis Apoptosis {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }}