P
Notes:
1:Clickable
2:Unclickable
cAMPPathway
AxonalGrowth
MKK4/7
REDD1
Cell Stress,Cytokines
MicrogliaActivation
GeneticMutations
Environmental Toxins,Neurotoxins
LRRK2 MutationPINK1Mutation
AggregationLewy Bodies
Proteosomal Degradation
Post-Synaptic Signaling Blocked
Neurodegeneration
CellSurvival
ROS
Dopamine
DopamineMetabolism
Parkin
PINK1
DJ-1
AKAP9
PP2A
Caln
Caln
IP
3
R
GeneExpression
Cell Survival
CaMKK
CaMK4
Calm
PP2B/CalnA1
CK1
PKG
cGMP
GTP
NO
Pi
PPtase1
sGC
bNOS
bNOS
DARPP32
Thr34
DARPP32
DARPP32
Thr72
β,γ
β,γ
Gα
i
Gα
S
AC
ATP
α-synucleinMisfolding
α-synuclein
Normal State
TyrosineHydroxylase
DopaDecarboxylase
Dopamine
Dopamine
Dopamine
PCP,Ketamine
Glycine
Glutamate
D-Serine
Par-4
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Tyrosine
L-DOPA
Parkinson’s Disease State
ATF1
CREM
CREB
CBP
AMPAR,
NMDAR
AMPAR,
NMDAR
Apoptosis
Apoptosis
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