Epigenetic “Writer”
Addition of Chemical
Modification
Recruitment
Alteration of
DNA-templated Process
Epigenetic “Eraser”
Removal of
Modification
MeCP2
AMBD1-4
Not clear - only putative targets so far:
- MBD2
- TET enzymes leading to iterative
oxydation resulting in eventual removal
of methyl-cytosine
Histone Acetyltransferases (HATs)
GCNS/PCAF
GNAT Related (e.g., HAT1, TFIIIC)
Myst Family (e.g., TIP60, HBO1)
CBP/p300 Family
TAF250 Family
Family (e.g., SRC1, TIF2)
Bromodomain Proteins
e.g.,
most HATs
BET Family (Brd2, Brd, Bdf1)
Brg-1
Histone Deacetylases (HDACs)
Class I
Class IIa
Class IIb
Sirtuins
Class IV
Lysine methyltransferases (KMTs)
KMT1A - KMT1F (e.g., G9a, GLP)
MLL Family (e.g., NSD1)
DOT1
KMT3A - KMT3C (e.g., NSD1)
DOT1
KMT5A, KMT5B (e.g., SUV420H1)
KMT6/ EZH2
KMT7/ SET7&9
KMT8/ RIZ1
Royal Family
- Chromo-domain Proteins,
e.g., HP-1 like, polycomb like,
CHD like
- Tudor-domain Proteins,
e.g., SMN
- PHD Proteins,
e.g., CBD, ING2, DNMT3L, PHF6
Lysine Demethylases (KDMs)
LSD1/ KDM1
JHDM/Jumonji (e.g., JHDM1A/B,
JHDM2A/B, JHDM3A-D,
JARID1A-D, UTX)
Histone Phosphorylation
Serine/Threonine Kinases
e.g.,
MST,
Haspin, VRK,
MSK1/2,
14-3-3 Proteins
Seven Isoforms: theta, gamma, zeta, eta,
epsilon, beta, mu
Protein Phosphatases
e.g.,
Serine/Threonine Protein Phosphatases
(PPP2CA, PPP2CB, PPP1CC),
Protein Phosphatase 1D,
Eye-absent Homologues (EYA1-3)
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