Notes:
	1:Clickable
	2:Unclickable
	
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
	
	
		
			
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
			
				
					
			
		
	
	
			
			
				
			
		
	
	
	
	
	
	
	
	
	
	
	
	
	
	Opioid
	AC
	CaMK IV
	CaMKK
	
		CaMK I
	
	PP1
	CREB
	PP2B
	PP2A
	PLCβ
	DAG
	VDCC
	IP
	3
	 Receptor
	Phosphorylation
	CRE Targeting Gene
	IP
	3
	PIP
	2
	Ca
	2+
	Ca
	2+
	Ca
	2+
	Ca
	2+
	α
	γ
	β
	  
          
            
            
            
          
    
	
        
          
          
          
          
          
             
        
        
            
            
            
        
        
            
            
        
        
            
            
        
    
	
	
	P
	
    
        
    
	
        
    
	
		
	
	
        
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	   
    
	
	
	    
    
	
        
    
    
        
    
    
        
    
    
        
    
	
	
		
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