Na + /H + Transporter MR/ClassicalAR MR/ClassicalAR MembraneAR PI3K Na + Channel PDK Raf MEK MAPK PKC HSP HSP Ca 2+ Channel PDE HDAC4/5 PKA-C PKA-R PKC Aldosterone SAHHydrolase IPYK PIP5K KRas2A PIP 2 PIP 3 SOS NEDD4 SGK MKP1 IP 3 Aldosterone Ca 2+ Mitochondria TnC IP 3 R RyR CaM CaMKII NFAT-3 MCIP-1 CREB Phospho-lamban Receptor α q CaM Calci-neurin PLC PLC SERCA TranscriptionFactors Translation Aldosterone MR/ClassicalAR MR/ClassicalAR SRE mRNA TranscriptionFactors Na + Ca 2+ Na + Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ ATP Contraction MAPK Pathway Ca 2+ CaMKIV Transcription Hypertrophy Ca 2+ GDP β γ β γ PIP 2 IP 3 DAG Ca 2+ Ca 2+ Sodium Channel InhibitorsAmilorideDigoxinOuabainRiluzoleCarbamazepine Calcium Channel InhibitorsVerapamilTetrandrineNifedipineAzelnidipine Proton Pump InhibitorsBafilomycin A1OmeprazoleNEXIUMZinc Pyrithione P MAPK Pathway Translation Aldosterone SRE mRNA Contraction ATP CaMKIV Transcription Hypertrophy GDP DAG Na Na + + Ca 2+ PIP 2 IP 3 Transcription Factors Transcription Factors MR/Classical AR MR/Classical AR Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ Ca 2+ {{ board.text }} IP 3 R SERCA RyR 2+ 3 SAH Hydrolase 2 3 Phospho-lamban β γ β γ α q Na + /H + Transporter Na + Channel Ca 2+ Channel {{ group.title }} {{ text.text }} {{ button.text }} {{ button.text1 }} {{ button.text2 }} {{ group.title }} {{ text.text }} < Notes: 1:Clickable 2:Unclickable