Na
+
/H
+
Transporter
MR/ClassicalAR
MR/ClassicalAR
MembraneAR
PI3K
Na
+
Channel
PDK
Raf
MEK
MAPK
PKC
HSP
HSP
Ca
2+
Channel
PDE
HDAC4/5
PKA-C
PKA-R
PKC
Aldosterone
SAHHydrolase
IPYK
PIP5K
KRas2A
PIP
2
PIP
3
SOS
NEDD4
SGK
MKP1
IP
3
Aldosterone
Ca
2+
Mitochondria
TnC
IP
3
R
RyR
CaM
CaMKII
NFAT-3
MCIP-1
CREB
Phospho-lamban
Receptor
α
q
CaM
Calci-neurin
PLC
PLC
SERCA
TranscriptionFactors
Translation
Aldosterone
MR/ClassicalAR
MR/ClassicalAR
SRE
mRNA
TranscriptionFactors
Na
+
Ca
2+
Na
+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
ATP
Contraction
MAPK Pathway
Ca
2+
CaMKIV
Transcription
Hypertrophy
Ca
2+
GDP
β
γ
β
γ
PIP
2
IP
3
DAG
Ca
2+
Ca
2+
Sodium Channel InhibitorsAmilorideDigoxinOuabainRiluzoleCarbamazepine
Calcium Channel InhibitorsVerapamilTetrandrineNifedipineAzelnidipine
Proton Pump InhibitorsBafilomycin A1OmeprazoleNEXIUMZinc Pyrithione
P
MAPK
Pathway
Translation
Aldosterone
SRE
mRNA
Contraction
ATP
CaMKIV
Transcription
Hypertrophy
GDP
DAG
Na
Na
+
+
Ca
2+
PIP
2
IP
3
Transcription
Factors
Transcription
Factors
MR/Classical
AR
MR/Classical
AR
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
Ca
2+
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IP
3
R
SERCA
RyR
2+
3
SAH
Hydrolase
2
3
Phospho-lamban
β
γ
β
γ
α
q
Na
+
/H
+
Transporter
Na
+
Channel
Ca
2+
Channel
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Notes:
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