Notes:
	1:Clickable
	2:Unclickable
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
	
		
			
			
				
					
			
		
	
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
			
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
		
			
			
				
			
		
	
	
			
			
				
			
		
	
			
			
				
			
		
	
			
			
				
			
		
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
			
				
					
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
				
			
				
			
		
	
	
		
			
			
				
			
		
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
		PLC-γ
	
	
		GAB1
	
	
		GRB2
	
	
		GRB2
	
	
		SOS
	
	
		Elk
	
	
		Shc
	
	
		Nck
	
	
		Crk
	
	
		Cbl
	
	
		Vav
	
	
		Elk
	
	
		Jun
	
	
		p27
	
	
		p21
	
	
		Cell CycleProgression
	
	
		Metabolism
	
	
		Cell Survival
	
	
		Bad
	
	
		eIF-4EBP
	
	
		NRG3
	
	
		NRG2
	
	
		NRG1
	
	
		NRG2
	
	
		HB-EGF
	
	
		BTC
	
	
		ERP
	
	
		Epiregulin
	
	
		TGFα
	
	
		EGF
	
	
		AR
	
	
		β-Cellulin
	
	
		Amphiregulin
	
	
		No Signaling
	
	
		Cellular Targets
	
	
		AdhesionMigration
	
	
		ReceptorUbiquitylation
	
	
		Degradation
	
	
		Activation byErbB2 Overexpression
	
	Protein Synthesis
	PIP
	3
	IP
	3
	Ca
	2+
	DG
	
		JNKK
	
	  
          
            
            
            
          
    
	
        
          
          
          
          
          
             
        
        
            
            
            
        
        
            
            
        
        
            
            
        
    
	
	
	P
	
    
        
    
	
        
    
	
		
	
	
        
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	    
    
	
	   
    
	
	
	    
    
	
        
    
    
        
    
    
        
    
    
        
    
	
	
		
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