cAMP PI3K Smo 5HT2B Glutamate ET1 5HT1D Akt Hedgehog JAK STAT PI3K Akt MEKs mTOR IKKs NF-κB p70S6K Ras Raf MEKs ERK PKA PAK p38 Rac PI3K Src Src Src Ras GEFs ROCK PKA MEKs ERK GEFs PKC ROCK Raf ERK MEKs Thrombin AC αi βγ αq βγ αs βγ αi βγ α12 βγ SOS GRB2 SHC GLI CDC42 PLCβ IP 3 AC Rho β-arrestin DAG GEFs Rho PTC MMPs GPCR HB-EGF EGFR cAMP Ca 2+ Transcription Factors Gene Expression Proliferation, Survival, Invasion,Migration, Angiogenesis Smoothened AntagonistsCyclopamineSonidegibSmoothened AgonistsSmoothened Agonist (SAG)Purmorphamine 5-HT Receptor InhibitorsVortioxetineRS-127445FluoxetineSertraline5-HT Receptor ActivatorsSerotoninPimavanserinTianeptine Sodium Endothelin ReceptorAntagonistsMacitentanBQ-123Bosentan cAMP ActivatorForskolincAMP InhibitorSQ22536 P {{ board.text }} MMPs PTC HB-EGF cAMP Ca 2+ Transcription Factors Gene Expression Proliferation, Survival, Invasion, Migration, Angiogenesis {{ board.text }} 3 {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ button.text }} {{ button.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable